Search of human proteins with 42544157

Search of human proteins with 42544157

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|42544157 hemojuvelin isoform c [Homo sapiens]
         (200 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|42544157 hemojuvelin isoform c [Homo sapiens]                      399   e-111
gi|44662823 hemojuvelin isoform b [Homo sapiens]                      399   e-111
gi|47458050 hemojuvelin isoform c [Homo sapiens]                      399   e-111
gi|47458048 hemojuvelin isoform a precursor [Homo sapiens]            399   e-111
gi|224589135 RGM domain family, member B [Homo sapiens]               166   1e-41
gi|24308189 RGM domain family, member A [Homo sapiens]                165   3e-41
gi|194097462 actin-like 9 [Homo sapiens]                               30   1.0  
gi|50659095 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 [Homo sapi...    30   1.8  
gi|169167062 PREDICTED: hypothetical protein LOC285556 [Homo sap...    29   2.3  
gi|113416182 PREDICTED: hypothetical protein LOC285556 [Homo sap...    29   2.3  
gi|113415686 PREDICTED: hypothetical protein LOC285556 [Homo sap...    29   2.3  
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]            28   4.0  
gi|110347429 mediator complex subunit 12 [Homo sapiens]                28   4.0  
gi|117606370 UMP-CMP kinase 2 [Homo sapiens]                           28   5.2  
gi|222352161 ATPase, class V, type 10D [Homo sapiens]                  28   5.2  
gi|32698952 hypothetical protein LOC283598 [Homo sapiens]              28   6.8  
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]       27   8.9  

>gi|42544157 hemojuvelin isoform c [Homo sapiens]
          Length = 200

 Score =  399 bits (1024), Expect = e-111
 Identities = 200/200 (100%), Positives = 200/200 (100%)

Query: 1   MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII 60
           MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII
Sbjct: 1   MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII 60

Query: 61  IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL 120
           IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL
Sbjct: 61  IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL 120

Query: 121 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS 180
           CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS
Sbjct: 121 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS 180

Query: 181 SATLLAPLLSGLFVLWLCIQ 200
           SATLLAPLLSGLFVLWLCIQ
Sbjct: 181 SATLLAPLLSGLFVLWLCIQ 200


>gi|44662823 hemojuvelin isoform b [Homo sapiens]
          Length = 313

 Score =  399 bits (1024), Expect = e-111
 Identities = 200/200 (100%), Positives = 200/200 (100%)

Query: 1   MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII 60
           MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII
Sbjct: 114 MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII 173

Query: 61  IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL 120
           IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL
Sbjct: 174 IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL 233

Query: 121 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS 180
           CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS
Sbjct: 234 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS 293

Query: 181 SATLLAPLLSGLFVLWLCIQ 200
           SATLLAPLLSGLFVLWLCIQ
Sbjct: 294 SATLLAPLLSGLFVLWLCIQ 313


>gi|47458050 hemojuvelin isoform c [Homo sapiens]
          Length = 200

 Score =  399 bits (1024), Expect = e-111
 Identities = 200/200 (100%), Positives = 200/200 (100%)

Query: 1   MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII 60
           MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII
Sbjct: 1   MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII 60

Query: 61  IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL 120
           IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL
Sbjct: 61  IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL 120

Query: 121 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS 180
           CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS
Sbjct: 121 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS 180

Query: 181 SATLLAPLLSGLFVLWLCIQ 200
           SATLLAPLLSGLFVLWLCIQ
Sbjct: 181 SATLLAPLLSGLFVLWLCIQ 200


>gi|47458048 hemojuvelin isoform a precursor [Homo sapiens]
          Length = 426

 Score =  399 bits (1024), Expect = e-111
 Identities = 200/200 (100%), Positives = 200/200 (100%)

Query: 1   MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII 60
           MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII
Sbjct: 227 MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII 286

Query: 61  IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL 120
           IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL
Sbjct: 287 IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL 346

Query: 121 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS 180
           CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS
Sbjct: 347 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS 406

Query: 181 SATLLAPLLSGLFVLWLCIQ 200
           SATLLAPLLSGLFVLWLCIQ
Sbjct: 407 SATLLAPLLSGLFVLWLCIQ 426


>gi|224589135 RGM domain family, member B [Homo sapiens]
          Length = 478

 Score =  166 bits (420), Expect = 1e-41
 Identities = 93/214 (43%), Positives = 123/214 (57%), Gaps = 20/214 (9%)

Query: 3   ECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTIIIR 62
           EC DQKVYQA  D+LP AF DG+ +GGD     SL I     G++VE+ A YIGTT+ +R
Sbjct: 266 ECTDQKVYQAVTDDLPAAFVDGTTSGGDSDA-KSLRIVERESGHYVEMHARYIGTTVFVR 324

Query: 63  QTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAI---------- 112
           Q    L+ +I++ ED+AM++   QDLQLCV GCP S+R+   +      +          
Sbjct: 325 QVGRYLTLAIRMPEDLAMSYEESQDLQLCVNGCPLSERIDDGQGQVSAILGHSLPRTSLV 384

Query: 113 ------TIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLE 166
                 T++TA   C E +PV+D YF SCVFD+L +GD NFT AA +ALED  A  P  E
Sbjct: 385 QAWPGYTLETANTQCHEKMPVKDIYFQSCVFDLLTTGDANFTAAAHSALEDVEALHPRKE 444

Query: 167 KLHLFPSDA-GVPLSSATLLAPLLSGLFVLWLCI 199
           + H+FPS   G P   + L   L  GL  L L +
Sbjct: 445 RWHIFPSSGNGTPRGGSDLSVSL--GLTCLILIV 476


>gi|24308189 RGM domain family, member A [Homo sapiens]
          Length = 450

 Score =  165 bits (417), Expect = 3e-41
 Identities = 97/223 (43%), Positives = 128/223 (57%), Gaps = 29/223 (13%)

Query: 2   QECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTIII 61
           QEC+DQKVYQAE+D LP AF DGS NGGD+ G +SL I     G HVEIQA YIGTTI++
Sbjct: 224 QECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVV 283

Query: 62  RQTAGQLSFSIKVAEDVAMAFS--AEQDLQLCVGGCPPSQRL--SRSERNRRG------- 110
           RQ    L+F++++ E+V  A      Q L LC+ GCP +Q++       N  G       
Sbjct: 284 RQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLA 343

Query: 111 ----------AITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARA 160
                         +TA   CKE LPVED Y+ +CVFD+L +GD NFT+AA  ALED + 
Sbjct: 344 AASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTTGDVNFTLAAYYALEDVKM 403

Query: 161 FLPDLEKLHLFP--------SDAGVPLSSATLLAPLLSGLFVL 195
              + +KLHL+         + AG+PL+   LL  L+  L +L
Sbjct: 404 LHSNKDKLHLYERTRDLPGRAAAGLPLAPRPLLGALVPLLALL 446


>gi|194097462 actin-like 9 [Homo sapiens]
          Length = 416

 Score = 30.4 bits (67), Expect = 1.0
 Identities = 21/75 (28%), Positives = 29/75 (38%)

Query: 122 KEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLSS 181
           K G+ V D    +C         P +TVA     +  +        L  F  +A   L  
Sbjct: 48  KTGVVVIDMGTGTCKVGFAGQASPTYTVATILGCQPKKPATSGQSGLQTFIGEAARVLPE 107

Query: 182 ATLLAPLLSGLFVLW 196
            TL+ PL SG+ V W
Sbjct: 108 LTLVQPLRSGIVVDW 122


>gi|50659095 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 [Homo
           sapiens]
          Length = 783

 Score = 29.6 bits (65), Expect = 1.8
 Identities = 23/101 (22%), Positives = 43/101 (42%), Gaps = 14/101 (13%)

Query: 45  GNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRS 104
           G+ + + + + G TII  +T        K A++++   + +QD Q   G  P  QR    
Sbjct: 428 GDVIRVYSGHQGRTIIFCETK-------KEAQELSQNSAIKQDAQSLHGDIPQKQREITL 480

Query: 105 ERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDP 145
           +  R G+  +  A  +   GL + +        D++I   P
Sbjct: 481 KGFRNGSFGVLVATNVAARGLDIPEV-------DLVIQSSP 514


>gi|169167062 PREDICTED: hypothetical protein LOC285556 [Homo
           sapiens]
          Length = 1826

 Score = 29.3 bits (64), Expect = 2.3
 Identities = 25/92 (27%), Positives = 42/92 (45%), Gaps = 17/92 (18%)

Query: 34  GSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQL-----------SFSIKVAEDVAMAF 82
           G  L ++ A P  + + + A +G  +   Q + +L           + S + A+ V M  
Sbjct: 173 GQGLIMEAAPPELNSKARQAEVGDGVSSAQDSQELKQQLWPLPKPSASSQREAKYVDMCA 232

Query: 83  SAE------QDLQLCVGGCPPSQRLSRSERNR 108
           SAE      Q ++L +G CP  QR SRS + +
Sbjct: 233 SAEVQRESPQTMKLTLGHCPGGQRASRSPKEK 264


>gi|113416182 PREDICTED: hypothetical protein LOC285556 [Homo
           sapiens]
          Length = 1826

 Score = 29.3 bits (64), Expect = 2.3
 Identities = 25/92 (27%), Positives = 42/92 (45%), Gaps = 17/92 (18%)

Query: 34  GSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQL-----------SFSIKVAEDVAMAF 82
           G  L ++ A P  + + + A +G  +   Q + +L           + S + A+ V M  
Sbjct: 173 GQGLIMEAAPPELNSKARQAEVGDGVSSAQDSQELKQQLWPLPKPSASSQREAKYVDMCA 232

Query: 83  SAE------QDLQLCVGGCPPSQRLSRSERNR 108
           SAE      Q ++L +G CP  QR SRS + +
Sbjct: 233 SAEVQRESPQTMKLTLGHCPGGQRASRSPKEK 264


>gi|113415686 PREDICTED: hypothetical protein LOC285556 [Homo
           sapiens]
          Length = 1826

 Score = 29.3 bits (64), Expect = 2.3
 Identities = 25/92 (27%), Positives = 42/92 (45%), Gaps = 17/92 (18%)

Query: 34  GSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQL-----------SFSIKVAEDVAMAF 82
           G  L ++ A P  + + + A +G  +   Q + +L           + S + A+ V M  
Sbjct: 173 GQGLIMEAAPPELNSKARQAEVGDGVSSAQDSQELKQQLWPLPKPSASSQREAKYVDMCA 232

Query: 83  SAE------QDLQLCVGGCPPSQRLSRSERNR 108
           SAE      Q ++L +G CP  QR SRS + +
Sbjct: 233 SAEVQRESPQTMKLTLGHCPGGQRASRSPKEK 264


>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
          Length = 3661

 Score = 28.5 bits (62), Expect = 4.0
 Identities = 27/125 (21%), Positives = 51/125 (40%), Gaps = 12/125 (9%)

Query: 36   SLSIQTANPGNHVEIQAAYIGTTIIIRQT-AGQLSFSIKVAEDVAMAFSAEQDLQLCVGG 94
            +L  + A    H+ +  A +GT  +  ++ A    FS  +   +      E  +  C GG
Sbjct: 1843 NLLCRVAQDSPHLILYPAIVGTISLSSESQASGNKFSTAIPTLLGNIQGEELLVSECEGG 1902

Query: 95   CPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAA 154
             PP+ + S  +  + G         L ++   ++D Y  S + D L S +P   +  Q  
Sbjct: 1903 SPPASQDSNKDEPKSG---------LNEDQAMMQDCY--SKIVDKLSSANPTMVLQVQML 1951

Query: 155  LEDAR 159
            + + R
Sbjct: 1952 VAELR 1956


>gi|110347429 mediator complex subunit 12 [Homo sapiens]
          Length = 2177

 Score = 28.5 bits (62), Expect = 4.0
 Identities = 14/46 (30%), Positives = 28/46 (60%), Gaps = 4/46 (8%)

Query: 22   EDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQ 67
            E G  +GG R GG ++S++TA+    +++ A Y+  +I  ++  G+
Sbjct: 1253 EGGGGSGGRRQGGRNISVETAS----LDVYAKYVLRSICQQEWVGE 1294


>gi|117606370 UMP-CMP kinase 2 [Homo sapiens]
          Length = 449

 Score = 28.1 bits (61), Expect = 5.2
 Identities = 26/89 (29%), Positives = 39/89 (43%), Gaps = 10/89 (11%)

Query: 86  QDLQLCVGGCP--PSQRLSRSERNRRGAI-----TIDTARRL---CKEGLPVEDAYFHSC 135
           Q L   +G C   P   L   E + RG +      +   RRL   C + +PV +   H  
Sbjct: 144 QALLELLGACQEAPRPHLGEFEADPRGQLWQRLWEVQDGRRLQVGCAQVVPVPEPPLHPV 203

Query: 136 VFDVLISGDPNFTVAAQAALEDARAFLPD 164
           V D+  S       AA+A LE+  +F+P+
Sbjct: 204 VPDLPSSVVFPDREAARAVLEECTSFIPE 232


>gi|222352161 ATPase, class V, type 10D [Homo sapiens]
          Length = 1426

 Score = 28.1 bits (61), Expect = 5.2
 Identities = 13/39 (33%), Positives = 21/39 (53%), Gaps = 4/39 (10%)

Query: 161 FLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFVLWLCI 199
           +L   EK+H F     VP     +++PLL+G ++ W  I
Sbjct: 343 WLSRYEKMHFF----NVPEPDGHIISPLLAGFYMFWTMI 377


>gi|32698952 hypothetical protein LOC283598 [Homo sapiens]
          Length = 125

 Score = 27.7 bits (60), Expect = 6.8
 Identities = 13/30 (43%), Positives = 17/30 (56%)

Query: 89  QLCVGGCPPSQRLSRSERNRRGAITIDTAR 118
           QL  G CP SQ L     N++ A+T+  AR
Sbjct: 35  QLGEGKCPSSQHLQSLRHNKQHALTLTKAR 64


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score = 27.3 bits (59), Expect = 8.9
 Identities = 15/66 (22%), Positives = 30/66 (45%)

Query: 31   RPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQL 90
            +P G+++ +   N   +V +      T  I +Q A  L    ++     ++   EQ+L+L
Sbjct: 4190 KPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELEL 4249

Query: 91   CVGGCP 96
             + G P
Sbjct: 4250 LISGLP 4255


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,677,750
Number of Sequences: 37866
Number of extensions: 315284
Number of successful extensions: 711
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 698
Number of HSP's gapped (non-prelim): 17
length of query: 200
length of database: 18,247,518
effective HSP length: 97
effective length of query: 103
effective length of database: 14,574,516
effective search space: 1501175148
effective search space used: 1501175148
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.