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Search of human proteins with 42544153
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42544153 leukocyte receptor tyrosine kinase isoform 1
precursor [Homo sapiens]
(864 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 1791 0.0
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 1566 0.0
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 910 0.0
gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precur... 706 0.0
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 285 1e-76
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 268 2e-71
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 265 1e-70
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 256 5e-68
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 256 5e-68
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 224 2e-58
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 224 2e-58
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 224 2e-58
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 218 2e-56
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 218 2e-56
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 213 5e-55
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens] 213 8e-55
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens] 213 8e-55
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 211 3e-54
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 211 3e-54
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 211 3e-54
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 211 3e-54
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 206 8e-53
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 205 1e-52
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 204 2e-52
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 204 2e-52
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 204 2e-52
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso... 202 8e-52
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 199 7e-51
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [... 199 7e-51
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 199 7e-51
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 1791 bits (4638), Expect = 0.0
Identities = 864/864 (100%), Positives = 864/864 (100%)
Query: 1 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 60
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
Sbjct: 1 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 60
Query: 61 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 120
SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
Sbjct: 61 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 120
Query: 121 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 180
ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
Sbjct: 121 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 180
Query: 181 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 240
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
Sbjct: 181 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 240
Query: 241 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC 300
RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
Sbjct: 241 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC 300
Query: 301 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF 360
SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
Sbjct: 301 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF 360
Query: 361 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK 420
LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
Sbjct: 361 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK 420
Query: 421 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA 480
PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA
Sbjct: 421 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA 480
Query: 481 PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ 540
PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ
Sbjct: 481 PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ 540
Query: 541 VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS 600
VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS
Sbjct: 541 VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS 600
Query: 601 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA 660
FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA
Sbjct: 601 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA 660
Query: 661 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG 720
KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG
Sbjct: 661 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG 720
Query: 721 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC 780
YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC
Sbjct: 721 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC 780
Query: 781 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL 840
TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL
Sbjct: 781 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL 840
Query: 841 SSGLKPLKSRGLQPQNLWNPTYRS 864
SSGLKPLKSRGLQPQNLWNPTYRS
Sbjct: 841 SSGLKPLKSRGLQPQNLWNPTYRS 864
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 1566 bits (4056), Expect = 0.0
Identities = 778/864 (90%), Positives = 780/864 (90%), Gaps = 61/864 (7%)
Query: 1 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 60
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
Sbjct: 1 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 60
Query: 61 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 120
SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
Sbjct: 61 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 120
Query: 121 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 180
ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
Sbjct: 121 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 180
Query: 181 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 240
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAA
Sbjct: 181 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAA-------- 232
Query: 241 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC 300
G GGR G T +P RS G+
Sbjct: 233 ----------------------GGGGRAYLRPRDRGRTQASPEKLENRSEAPGS------ 264
Query: 301 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF 360
GG GG GGDASETDNLWADGEDGVSFIHPSSELF
Sbjct: 265 -------------------------GGRGGAAGGDASETDNLWADGEDGVSFIHPSSELF 299
Query: 361 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK 420
LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
Sbjct: 300 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK 359
Query: 421 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA 480
PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA
Sbjct: 360 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA 419
Query: 481 PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ 540
PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ
Sbjct: 420 PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ 479
Query: 541 VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS 600
VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS
Sbjct: 480 VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS 539
Query: 601 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA 660
FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA
Sbjct: 540 FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA 599
Query: 661 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG 720
KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG
Sbjct: 600 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG 659
Query: 721 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC 780
YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC
Sbjct: 660 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC 719
Query: 781 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL 840
TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL
Sbjct: 720 TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL 779
Query: 841 SSGLKPLKSRGLQPQNLWNPTYRS 864
SSGLKPLKSRGLQPQNLWNPTYRS
Sbjct: 780 SSGLKPLKSRGLQPQNLWNPTYRS 803
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 910 bits (2352), Expect = 0.0
Identities = 477/858 (55%), Positives = 585/858 (68%), Gaps = 33/858 (3%)
Query: 4 WGQLLVWFGAAGAILCSSPG---SQETFLRSSP----LPLASPSPRDPKVSAPPSILEPA 56
W Q++ W+G + + S + +L S L +P R+ P L+P
Sbjct: 608 WLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPG 667
Query: 57 --SPLNSPGTEGS--WLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWR 112
SP +P + + WLF+TCGASG HGPTQ QC+ AY +++ V VG+ G L+G+Q+W+
Sbjct: 668 ENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWK 727
Query: 113 VPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGS 172
VP Y IS YGAAGGKG KN + R+HGV V IF+L + LYILVGQQGEDACP +
Sbjct: 728 VPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTN 787
Query: 173 PESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAA 232
Q VC+GE+ +EE ++ S WAGGGGGGGGATYVF+++ G PL++AA
Sbjct: 788 QLIQKVCIGENNVIEEEIRVNRSV-----HEWAGGGGGGGGATYVFKMKDGVPVPLIIAA 842
Query: 233 GGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQE 292
GGGGRAY D PE+LEN S G G GAAGGGGGW AG+SLQE
Sbjct: 843 GGGGRAYGAKTDTFH----PERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQE 898
Query: 293 GAEGGQGCSEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSF 352
GA GG C +A GW GGFGGGGG C++GGGGGGY GG+A+ ++ DGEDGVSF
Sbjct: 899 GATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSF 958
Query: 353 IHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDN 412
I P L+ L V E HGEV I+ +LNCSHC + +C E C C G LA D
Sbjct: 959 ISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDG 1018
Query: 413 VTCM--DLHKPPGPLVLMVAVVATSTLSLLMVC--GVLILVKQKKWQGLQ--EMRLPSPE 466
V+C+ +P PL L+++VV ++ ++ L++ G++I V ++K Q LQ +M L SPE
Sbjct: 1019 VSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMI-VYRRKHQELQAMQMELQSPE 1077
Query: 467 LELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYE 526
+LSKLRTS I T NP YC G + S + EV N+TL+R LGHGAFGEVYE
Sbjct: 1078 YKLSKLRTSTIMTDYNPNYCFAGKTSSIS-----DLKEVPRKNITLIRGLGHGAFGEVYE 1132
Query: 527 GLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPR 586
G V G+P D SPLQVA+KTLPE+CS QDELDFLMEALIISKF HQNIVRC+G+SL++ PR
Sbjct: 1133 GQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPR 1192
Query: 587 LILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAA 646
ILLELM+GGD+KSFLR +RP QPS L M DLL +A+DIA GC YLEENHFIHRDIAA
Sbjct: 1193 FILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAA 1252
Query: 647 RNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDS 706
RNCLL+C GP RVAKIGDFGMARDIYRASYYR+G A+LPVKWMPPEAF+EGIFTSKTD+
Sbjct: 1253 RNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDT 1312
Query: 707 WSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPEL 766
WSFGVLLWEIFSLGYMPYP ++NQEVL+FV GGRMDPP+ CPGPVYRIMTQCWQH+PE
Sbjct: 1313 WSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPED 1372
Query: 767 RPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRP-PQPQELSP 825
RP+FA ILER++YCTQDPDV+N+ LP+E GP EEE + + E + P Q+
Sbjct: 1373 RPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKR 1432
Query: 826 EKLKSWGGSPLGPWLSSG 843
E+ +S P P SSG
Sbjct: 1433 EEERSPAAPPPLPTTSSG 1450
>gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precursor
[Homo sapiens]
Length = 734
Score = 706 bits (1822), Expect = 0.0
Identities = 362/448 (80%), Positives = 364/448 (81%), Gaps = 61/448 (13%)
Query: 1 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 60
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
Sbjct: 1 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 60
Query: 61 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 120
SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
Sbjct: 61 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 120
Query: 121 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 180
ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
Sbjct: 121 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 180
Query: 181 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 240
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAA
Sbjct: 181 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAA-------- 232
Query: 241 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC 300
G GGR G T +P RS G+
Sbjct: 233 ----------------------GGGGRAYLRPRDRGRTQASPEKLENRSEAPGS------ 264
Query: 301 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF 360
GG GG GGDASETDNLWADGEDGVSFIHPSSELF
Sbjct: 265 -------------------------GGRGGAAGGDASETDNLWADGEDGVSFIHPSSELF 299
Query: 361 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK 420
LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
Sbjct: 300 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK 359
Query: 421 PPGPLVLMVAVVATSTLSLLMVCGVLIL 448
PPGPLVLMVAVVATSTLSLLMVCGVLIL
Sbjct: 360 PPGPLVLMVAVVATSTLSLLMVCGVLIL 387
Score = 675 bits (1741), Expect = 0.0
Identities = 334/379 (88%), Positives = 340/379 (89%), Gaps = 17/379 (4%)
Query: 499 PPG-----VTEVSPANVTLLRALGHGAFGEVYEGLVI--------GLPGDSSPLQVAIKT 545
PPG V V+ + ++LL G G + G V+ G P Q T
Sbjct: 360 PPGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQ----T 415
Query: 546 LPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHS 605
LPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHS
Sbjct: 416 LPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHS 475
Query: 606 RPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDF 665
RPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDF
Sbjct: 476 RPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDF 535
Query: 666 GMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYP 725
GMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYP
Sbjct: 536 GMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYP 595
Query: 726 GRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPD 785
GRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPD
Sbjct: 596 GRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPD 655
Query: 786 VLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLK 845
VLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLK
Sbjct: 656 VLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLK 715
Query: 846 PLKSRGLQPQNLWNPTYRS 864
PLKSRGLQPQNLWNPTYRS
Sbjct: 716 PLKSRGLQPQNLWNPTYRS 734
>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
Length = 2347
Score = 285 bits (730), Expect = 1e-76
Identities = 141/307 (45%), Positives = 206/307 (67%), Gaps = 10/307 (3%)
Query: 510 VTLLRALGHGAFGEVYEGLVIGLPG-DSSPLQVAIKTLPELCSPQDELDFLMEALIISKF 568
+TL LG GAFGEVYEG + + G S ++VA+KTL + + Q++++FL EA ++SKF
Sbjct: 1945 LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKF 2004
Query: 569 RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIA 628
H NI++ +G+ L P+ I+LELM GGD+ ++LR +R L + DL+ L DI+
Sbjct: 2005 NHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDIS 2064
Query: 629 QGCHYLEENHFIHRDIAARNCLLSCAGPS--RVAKIGDFGMARDIYRASYYRRGDRALLP 686
+GC YLE HFIHRD+AARNCL+S + R+ KIGDFG+ARDIY+ YYR+ LLP
Sbjct: 2065 KGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLP 2124
Query: 687 VKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPR 746
V+WM PE+ ++GIFT+++D WSFG+L+WEI +LG+ PYP +N +VL++V GGR++PPR
Sbjct: 2125 VRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPR 2184
Query: 747 GCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSG 806
CP ++ +MTQCW EP+ RP+F I ++LQ + + + + +E SG
Sbjct: 2185 NCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ-------LFRNFFLNSIYKSRDEANNSG 2237
Query: 807 LGNRSLE 813
+ N S E
Sbjct: 2238 VINESFE 2244
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 268 bits (685), Expect = 2e-71
Identities = 140/332 (42%), Positives = 203/332 (61%), Gaps = 14/332 (4%)
Query: 500 PGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFL 559
P EV ++++R LG G+FG VYEGL GL VA+KT+ EL SP++ ++FL
Sbjct: 969 PDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFL 1028
Query: 560 MEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL----GQPSPL 615
EA ++ F+ ++VR +G+ + P L+++ELM+ GD+KS LR RP G P P
Sbjct: 1029 KEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQP- 1087
Query: 616 VMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRAS 675
+ +++Q+A +IA G YL N F+HRD+AARNC++S KIGDFGM RD+Y
Sbjct: 1088 ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVS---QDFTVKIGDFGMTRDVYETD 1144
Query: 676 YYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDF 735
YYR+G + LLPV+WM PE+ +GIFT+ +D WSFGV+LWEI +L PY G +N++VL F
Sbjct: 1145 YYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKF 1204
Query: 736 VVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMEL 795
V+ GG ++ GCP + +M++CWQ P LRPSF IL+ +Q ++ S +
Sbjct: 1205 VMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQ-----EELRPSFRLLSF 1259
Query: 796 GPTPEEEGTSG-LGNRSLECLRPPQPQELSPE 826
+PE G G L E P P++ SP+
Sbjct: 1260 YYSPECRGARGSLPTTDAEPDSSPTPRDCSPQ 1291
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 265 bits (677), Expect = 1e-70
Identities = 145/385 (37%), Positives = 217/385 (56%), Gaps = 34/385 (8%)
Query: 470 SKLRTSAIRTAPNP-YYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGL 528
S+L + + NP Y+ + W EV+ +T+ R LG G+FG VYEG+
Sbjct: 965 SRLGNGVLYASVNPEYFSAADVYVPDEW-------EVAREKITMSRELGQGSFGMVYEGV 1017
Query: 529 VIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLI 588
G+ D +VAIKT+ E S ++ ++FL EA ++ +F ++VR +G+ + P L+
Sbjct: 1018 AKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV 1077
Query: 589 LLELMSGGDMKSFLRHSRPHLGQP---SPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIA 645
++ELM+ GD+KS+LR RP + +P + ++Q+A +IA G YL N F+HRD+A
Sbjct: 1078 IMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLA 1137
Query: 646 ARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTD 705
ARNC+++ KIGDFGM RDIY YYR+G + LLPV+WM PE+ +G+FT+ +D
Sbjct: 1138 ARNCMVA---EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSD 1194
Query: 706 SWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPE 765
WSFGV+LWEI +L PY G +N++VL FV+ GG +D P CP ++ +M CWQ+ P+
Sbjct: 1195 VWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPK 1254
Query: 766 LRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSP 825
+RPSF I+ ++ + S E PE P+ +L P
Sbjct: 1255 MRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPE-----------------PEELDLEP 1297
Query: 826 EKLKSWGGSPLGPWLSSGLKPLKSR 850
E ++S PL P SS PL R
Sbjct: 1298 ENMES---VPLDPSASSSSLPLPDR 1319
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 256 bits (655), Expect = 5e-68
Identities = 126/283 (44%), Positives = 183/283 (64%), Gaps = 8/283 (2%)
Query: 500 PGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFL 559
P EVS +TLLR LG G+FG VYEG + + +VA+KT+ E S ++ ++FL
Sbjct: 1001 PDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFL 1060
Query: 560 MEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL----GQPSPL 615
EA ++ F ++VR +G+ + P L+++ELM+ GD+KS+LR RP G+P P
Sbjct: 1061 NEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPP- 1119
Query: 616 VMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRAS 675
+++++Q+A +IA G YL F+HRD+AARNC+++ KIGDFGM RDIY
Sbjct: 1120 TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA---HDFTVKIGDFGMTRDIYETD 1176
Query: 676 YYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDF 735
YYR+G + LLPV+WM PE+ +G+FT+ +D WSFGV+LWEI SL PY G +N++VL F
Sbjct: 1177 YYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKF 1236
Query: 736 VVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 778
V+ GG +D P CP V +M CWQ P++RP+F I+ L+
Sbjct: 1237 VMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1279
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 256 bits (655), Expect = 5e-68
Identities = 126/283 (44%), Positives = 183/283 (64%), Gaps = 8/283 (2%)
Query: 500 PGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFL 559
P EVS +TLLR LG G+FG VYEG + + +VA+KT+ E S ++ ++FL
Sbjct: 1013 PDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFL 1072
Query: 560 MEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL----GQPSPL 615
EA ++ F ++VR +G+ + P L+++ELM+ GD+KS+LR RP G+P P
Sbjct: 1073 NEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPP- 1131
Query: 616 VMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRAS 675
+++++Q+A +IA G YL F+HRD+AARNC+++ KIGDFGM RDIY
Sbjct: 1132 TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA---HDFTVKIGDFGMTRDIYETD 1188
Query: 676 YYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDF 735
YYR+G + LLPV+WM PE+ +G+FT+ +D WSFGV+LWEI SL PY G +N++VL F
Sbjct: 1189 YYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKF 1248
Query: 736 VVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 778
V+ GG +D P CP V +M CWQ P++RP+F I+ L+
Sbjct: 1249 VMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1291
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
1 [Homo sapiens]
Length = 790
Score = 224 bits (572), Expect = 2e-58
Identities = 123/298 (41%), Positives = 165/298 (55%), Gaps = 12/298 (4%)
Query: 502 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 561
V + ++ L LG GAFG+V+ L + + VA+K L E S DF E
Sbjct: 496 VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQRE 554
Query: 562 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLG--------QPS 613
A +++ +HQ+IVR G+ P L++ E M GD+ FLR P P
Sbjct: 555 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 614
Query: 614 PLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYR 673
PL + LL +A +A G YL HF+HRD+A RNCL+ G V KIGDFGM+RDIY
Sbjct: 615 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYS 671
Query: 674 ASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL 733
YYR G R +LP++WMPPE+ L FT+++D WSFGV+LWEIF+ G P+ +N E +
Sbjct: 672 TDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI 731
Query: 734 DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLL 791
D + G ++ PR CP VY IM CWQ EP+ R S + RLQ Q P V +L
Sbjct: 732 DCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVL 789
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 224 bits (572), Expect = 2e-58
Identities = 123/298 (41%), Positives = 165/298 (55%), Gaps = 12/298 (4%)
Query: 502 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 561
V + ++ L LG GAFG+V+ L + + VA+K L E S DF E
Sbjct: 502 VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQRE 560
Query: 562 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLG--------QPS 613
A +++ +HQ+IVR G+ P L++ E M GD+ FLR P P
Sbjct: 561 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 620
Query: 614 PLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYR 673
PL + LL +A +A G YL HF+HRD+A RNCL+ G V KIGDFGM+RDIY
Sbjct: 621 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYS 677
Query: 674 ASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL 733
YYR G R +LP++WMPPE+ L FT+++D WSFGV+LWEIF+ G P+ +N E +
Sbjct: 678 TDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI 737
Query: 734 DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLL 791
D + G ++ PR CP VY IM CWQ EP+ R S + RLQ Q P V +L
Sbjct: 738 DCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVL 795
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
3 [Homo sapiens]
Length = 760
Score = 224 bits (572), Expect = 2e-58
Identities = 123/298 (41%), Positives = 165/298 (55%), Gaps = 12/298 (4%)
Query: 502 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 561
V + ++ L LG GAFG+V+ L + + VA+K L E S DF E
Sbjct: 466 VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQRE 524
Query: 562 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLG--------QPS 613
A +++ +HQ+IVR G+ P L++ E M GD+ FLR P P
Sbjct: 525 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 584
Query: 614 PLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYR 673
PL + LL +A +A G YL HF+HRD+A RNCL+ G V KIGDFGM+RDIY
Sbjct: 585 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYS 641
Query: 674 ASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL 733
YYR G R +LP++WMPPE+ L FT+++D WSFGV+LWEIF+ G P+ +N E +
Sbjct: 642 TDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI 701
Query: 734 DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLL 791
D + G ++ PR CP VY IM CWQ EP+ R S + RLQ Q P V +L
Sbjct: 702 DCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVL 759
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
c precursor [Homo sapiens]
Length = 822
Score = 218 bits (554), Expect = 2e-56
Identities = 111/283 (39%), Positives = 161/283 (56%), Gaps = 10/283 (3%)
Query: 502 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 561
V + N+ L R LG GAFG+V+ L + + VA+KTL + S DF E
Sbjct: 530 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNARKDFHRE 588
Query: 562 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL------GQPSPL 615
A +++ +H++IV+ G+ + P +++ E M GD+ FLR P P+ L
Sbjct: 589 AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 648
Query: 616 VMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRAS 675
+L +AQ IA G YL HF+HRD+A RNCL+ G + + KIGDFGM+RD+Y
Sbjct: 649 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GENLLVKIGDFGMSRDVYSTD 705
Query: 676 YYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDF 735
YYR G +LP++WMPPE+ + FT+++D WS GV+LWEIF+ G P+ +N EV++
Sbjct: 706 YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIEC 765
Query: 736 VVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 778
+ G + PR CP VY +M CWQ EP +R + I LQ
Sbjct: 766 ITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQ 808
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
a precursor [Homo sapiens]
Length = 838
Score = 218 bits (554), Expect = 2e-56
Identities = 111/283 (39%), Positives = 161/283 (56%), Gaps = 10/283 (3%)
Query: 502 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 561
V + N+ L R LG GAFG+V+ L + + VA+KTL + S DF E
Sbjct: 546 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNARKDFHRE 604
Query: 562 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL------GQPSPL 615
A +++ +H++IV+ G+ + P +++ E M GD+ FLR P P+ L
Sbjct: 605 AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 664
Query: 616 VMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRAS 675
+L +AQ IA G YL HF+HRD+A RNCL+ G + + KIGDFGM+RD+Y
Sbjct: 665 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GENLLVKIGDFGMSRDVYSTD 721
Query: 676 YYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDF 735
YYR G +LP++WMPPE+ + FT+++D WS GV+LWEIF+ G P+ +N EV++
Sbjct: 722 YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIEC 781
Query: 736 VVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 778
+ G + PR CP VY +M CWQ EP +R + I LQ
Sbjct: 782 ITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQ 824
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 213 bits (543), Expect = 5e-55
Identities = 127/382 (33%), Positives = 201/382 (52%), Gaps = 37/382 (9%)
Query: 421 PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKK-WQGLQEMRLPSPELELSKLRTSAI-- 477
P + ++++++++ + +L+ L +++K W+ + S + L+ L + +
Sbjct: 490 PTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKR---ESAAVTLTTLPSELLLD 546
Query: 478 RTAPNPYYCQVGLGPAQSWPLPPGVT--EVSPANVTLLRALGHGAFGEVYEGLVIGLPGD 535
R PNP Y ++ L L P + E N+ +R +G GAFG V++ GL
Sbjct: 547 RLHPNPMYQRMPL------LLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPY 600
Query: 536 SSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSG 595
VA+K L E S + DF EA ++++F + NIV+ +G+ P +L E M+
Sbjct: 601 EPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAY 660
Query: 596 GDMKSFLRHSRPHL-----------------GQPSPLVMRDLLQLAQDIAQGCHYLEENH 638
GD+ FLR PH P PL + L +A+ +A G YL E
Sbjct: 661 GDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERK 720
Query: 639 FIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEG 698
F+HRD+A RNCL+ G + V KI DFG++R+IY A YY+ + +P++WMPPE+
Sbjct: 721 FVHRDLATRNCLV---GENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYN 777
Query: 699 IFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQ 758
+T+++D W++GV+LWEIFS G PY G ++EV+ +V G + P CP +Y +M
Sbjct: 778 RYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRL 837
Query: 759 CWQHEPELRPSFAS---ILERL 777
CW P RPSF S ILER+
Sbjct: 838 CWSKLPADRPSFTSIHRILERM 859
>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
Length = 885
Score = 213 bits (541), Expect = 8e-55
Identities = 139/396 (35%), Positives = 213/396 (53%), Gaps = 25/396 (6%)
Query: 426 VLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELS-KLRTSAIRTAPNPY 484
VL+ AVVA + + +L + V K+ ++ + E + EL + ++R S R
Sbjct: 444 VLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEAT 503
Query: 485 YCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIK 544
+G+ L + V V L + LG G FG V EG L D S L+VA+K
Sbjct: 504 LNSLGISEELKEKLRDVM--VDRHKVALGKTLGEGEFGAVMEGQ---LNQDDSILKVAVK 558
Query: 545 TLP-ELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPR------LILLELMSGGD 597
T+ +C+ + DFL EA+ + +F H N++R +G+ + + R +++L M GD
Sbjct: 559 TMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGD 618
Query: 598 MKSFLRHSRPHLG-QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGP 656
+ SFL +SR LG QP L + L++ DIA G YL FIHRD+AARNC+L+
Sbjct: 619 LHSFLLYSR--LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLN---E 673
Query: 657 SRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEI 716
+ + DFG+++ IY YYR+G A +PVKW+ E+ + ++TSK+D WSFGV +WEI
Sbjct: 674 NMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEI 733
Query: 717 FSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILER 776
+ G PYPG N E+ D++ G R+ P C +Y +M++CW+ P+ RPSF + E
Sbjct: 734 ATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRED 793
Query: 777 LQYC------TQDPDVLNSLLPMELGPTPEEEGTSG 806
L+ Q+PD + + E G PE G +G
Sbjct: 794 LENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAG 829
>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
Length = 894
Score = 213 bits (541), Expect = 8e-55
Identities = 139/396 (35%), Positives = 213/396 (53%), Gaps = 25/396 (6%)
Query: 426 VLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELS-KLRTSAIRTAPNPY 484
VL+ AVVA + + +L + V K+ ++ + E + EL + ++R S R
Sbjct: 453 VLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEAT 512
Query: 485 YCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIK 544
+G+ L + V V L + LG G FG V EG L D S L+VA+K
Sbjct: 513 LNSLGISEELKEKLRDVM--VDRHKVALGKTLGEGEFGAVMEGQ---LNQDDSILKVAVK 567
Query: 545 TLP-ELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPR------LILLELMSGGD 597
T+ +C+ + DFL EA+ + +F H N++R +G+ + + R +++L M GD
Sbjct: 568 TMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGD 627
Query: 598 MKSFLRHSRPHLG-QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGP 656
+ SFL +SR LG QP L + L++ DIA G YL FIHRD+AARNC+L+
Sbjct: 628 LHSFLLYSR--LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLN---E 682
Query: 657 SRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEI 716
+ + DFG+++ IY YYR+G A +PVKW+ E+ + ++TSK+D WSFGV +WEI
Sbjct: 683 NMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEI 742
Query: 717 FSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILER 776
+ G PYPG N E+ D++ G R+ P C +Y +M++CW+ P+ RPSF + E
Sbjct: 743 ATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRED 802
Query: 777 LQYC------TQDPDVLNSLLPMELGPTPEEEGTSG 806
L+ Q+PD + + E G PE G +G
Sbjct: 803 LENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAG 838
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 211 bits (536), Expect = 3e-54
Identities = 116/270 (42%), Positives = 161/270 (59%), Gaps = 14/270 (5%)
Query: 509 NVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKF 568
++ L +G G FGEV+ G L D++ VA+K+ E P + FL EA I+ ++
Sbjct: 432 DLVLGEQIGRGNFGEVFSGR---LRADNT--LVAVKSCRETLPPDLKAKFLQEARILKQY 486
Query: 569 RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIA 628
H NIVR +G+ + P I++EL+ GGD +FLR + + L ++ LLQ+ D A
Sbjct: 487 SHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT------EGARLRVKTLLQMVGDAA 540
Query: 629 QGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVK 688
G YLE IHRD+AARNCL++ V KI DFGM+R+ Y G +PVK
Sbjct: 541 AGMEYLESKCCIHRDLAARNCLVT---EKNVLKISDFGMSREEADGVYAASGGLRQVPVK 597
Query: 689 WMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGC 748
W PEA G ++S++D WSFG+LLWE FSLG PYP +NQ+ +FV GGR+ P C
Sbjct: 598 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELC 657
Query: 749 PGPVYRIMTQCWQHEPELRPSFASILERLQ 778
P V+R+M QCW +EP RPSF++I + LQ
Sbjct: 658 PDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 687
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 211 bits (536), Expect = 3e-54
Identities = 116/270 (42%), Positives = 161/270 (59%), Gaps = 14/270 (5%)
Query: 509 NVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKF 568
++ L +G G FGEV+ G L D++ VA+K+ E P + FL EA I+ ++
Sbjct: 490 DLVLGEQIGRGNFGEVFSGR---LRADNT--LVAVKSCRETLPPDLKAKFLQEARILKQY 544
Query: 569 RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIA 628
H NIVR +G+ + P I++EL+ GGD +FLR + + L ++ LLQ+ D A
Sbjct: 545 SHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT------EGARLRVKTLLQMVGDAA 598
Query: 629 QGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVK 688
G YLE IHRD+AARNCL++ V KI DFGM+R+ Y G +PVK
Sbjct: 599 AGMEYLESKCCIHRDLAARNCLVT---EKNVLKISDFGMSREEADGVYAASGGLRQVPVK 655
Query: 689 WMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGC 748
W PEA G ++S++D WSFG+LLWE FSLG PYP +NQ+ +FV GGR+ P C
Sbjct: 656 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELC 715
Query: 749 PGPVYRIMTQCWQHEPELRPSFASILERLQ 778
P V+R+M QCW +EP RPSF++I + LQ
Sbjct: 716 PDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 745
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 211 bits (536), Expect = 3e-54
Identities = 116/270 (42%), Positives = 161/270 (59%), Gaps = 14/270 (5%)
Query: 509 NVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKF 568
++ L +G G FGEV+ G L D++ VA+K+ E P + FL EA I+ ++
Sbjct: 502 DLVLGEQIGRGNFGEVFSGR---LRADNT--LVAVKSCRETLPPDLKAKFLQEARILKQY 556
Query: 569 RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIA 628
H NIVR +G+ + P I++EL+ GGD +FLR + + L ++ LLQ+ D A
Sbjct: 557 SHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT------EGARLRVKTLLQMVGDAA 610
Query: 629 QGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVK 688
G YLE IHRD+AARNCL++ V KI DFGM+R+ Y G +PVK
Sbjct: 611 AGMEYLESKCCIHRDLAARNCLVT---EKNVLKISDFGMSREEADGVYAASGGLRQVPVK 667
Query: 689 WMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGC 748
W PEA G ++S++D WSFG+LLWE FSLG PYP +NQ+ +FV GGR+ P C
Sbjct: 668 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELC 727
Query: 749 PGPVYRIMTQCWQHEPELRPSFASILERLQ 778
P V+R+M QCW +EP RPSF++I + LQ
Sbjct: 728 PDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 757
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 211 bits (536), Expect = 3e-54
Identities = 116/270 (42%), Positives = 161/270 (59%), Gaps = 14/270 (5%)
Query: 509 NVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKF 568
++ L +G G FGEV+ G L D++ VA+K+ E P + FL EA I+ ++
Sbjct: 560 DLVLGEQIGRGNFGEVFSGR---LRADNT--LVAVKSCRETLPPDLKAKFLQEARILKQY 614
Query: 569 RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIA 628
H NIVR +G+ + P I++EL+ GGD +FLR + + L ++ LLQ+ D A
Sbjct: 615 SHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT------EGARLRVKTLLQMVGDAA 668
Query: 629 QGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVK 688
G YLE IHRD+AARNCL++ V KI DFGM+R+ Y G +PVK
Sbjct: 669 AGMEYLESKCCIHRDLAARNCLVT---EKNVLKISDFGMSREEADGVYAASGGLRQVPVK 725
Query: 689 WMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGC 748
W PEA G ++S++D WSFG+LLWE FSLG PYP +NQ+ +FV GGR+ P C
Sbjct: 726 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELC 785
Query: 749 PGPVYRIMTQCWQHEPELRPSFASILERLQ 778
P V+R+M QCW +EP RPSF++I + LQ
Sbjct: 786 PDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 815
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
b precursor [Homo sapiens]
Length = 825
Score = 206 bits (524), Expect = 8e-53
Identities = 111/287 (38%), Positives = 163/287 (56%), Gaps = 17/287 (5%)
Query: 502 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTL--PELCSPQDELDFL 559
V + ++ L R LG GAFG+V+ L + VA+K L P L + +D F
Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKD---FQ 586
Query: 560 MEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL-----GQP-- 612
EA +++ +H++IV+ G+ P +++ E M GD+ FLR P GQP
Sbjct: 587 REAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQ 646
Query: 613 --SPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARD 670
L + +L +A IA G YL HF+HRD+A RNCL+ G + + KIGDFGM+RD
Sbjct: 647 AKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV---GANLLVKIGDFGMSRD 703
Query: 671 IYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQ 730
+Y YYR G +LP++WMPPE+ + FT+++D WSFGV+LWEIF+ G P+ +N
Sbjct: 704 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNT 763
Query: 731 EVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERL 777
EV++ + G ++ PR CP VY +M CWQ EP+ R + I + L
Sbjct: 764 EVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL 810
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 205 bits (522), Expect = 1e-52
Identities = 112/273 (41%), Positives = 161/273 (58%), Gaps = 16/273 (5%)
Query: 505 VSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALI 564
+S +V L LG G FGEVY+G + VA+KT E + ++ FL EA I
Sbjct: 558 LSHEDVILGELLGKGNFGEVYKGTL------KDKTSVAVKTCKEDLPQELKIKFLQEAKI 611
Query: 565 ISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLA 624
+ ++ H NIV+ +G+ + P I++EL+SGGD +FLR + L ++ L++ +
Sbjct: 612 LKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELK------LKQLVKFS 665
Query: 625 QDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRAL 684
D A G YLE + IHRD+AARNCL+ G + V KI DFGM+R Y G + +
Sbjct: 666 LDAAAGMLYLESKNCIHRDLAARNCLV---GENNVLKISDFGMSRQEDGGVYSSSGLKQI 722
Query: 685 LPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDP 744
P+KW PEA G ++S++D WSFG+LLWE FSLG PYPG TNQ+ + V G RM
Sbjct: 723 -PIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSA 781
Query: 745 PRGCPGPVYRIMTQCWQHEPELRPSFASILERL 777
P+ CP + +IM +CW ++PE RP F+ + + L
Sbjct: 782 PQHCPEDISKIMMKCWDYKPENRPKFSELQKEL 814
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 204 bits (520), Expect = 2e-52
Identities = 120/336 (35%), Positives = 176/336 (52%), Gaps = 22/336 (6%)
Query: 504 EVSPANVTLLRALGHGAFGEVYEGLVIGLPGD--SSPLQVAIKTLPELCSPQDELDFLME 561
E+S A +TL + LG G FG+V IG+ D + P+ VA+K L + + +D D + E
Sbjct: 468 ELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSE 527
Query: 562 ALIISKF-RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPH---------LGQ 611
++ +H+NI+ +G + P +L+E + G+++ FLR RP
Sbjct: 528 MEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPP 587
Query: 612 PSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDI 671
L +DL+ A +A+G YL IHRD+AARN L++ V KI DFG+ARD+
Sbjct: 588 EEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVT---EDNVMKIADFGLARDV 644
Query: 672 YRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQE 731
+ YY++ LPVKWM PEA + ++T ++D WSFGVLLWEIF+LG PYPG +E
Sbjct: 645 HNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEE 704
Query: 732 VLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASI---LERLQYCTQDPDVLN 788
+ + G RMD P C +Y IM +CW P RP+F + L+R+ T + L+
Sbjct: 705 LFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLD 764
Query: 789 SLLPMEL----GPTPEEEGTSGLGNRSLECLRPPQP 820
P E G +SG + L PP P
Sbjct: 765 LSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 800
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 204 bits (520), Expect = 2e-52
Identities = 120/336 (35%), Positives = 176/336 (52%), Gaps = 22/336 (6%)
Query: 504 EVSPANVTLLRALGHGAFGEVYEGLVIGLPGD--SSPLQVAIKTLPELCSPQDELDFLME 561
E+S A +TL + LG G FG+V IG+ D + P+ VA+K L + + +D D + E
Sbjct: 354 ELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSE 413
Query: 562 ALIISKF-RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPH---------LGQ 611
++ +H+NI+ +G + P +L+E + G+++ FLR RP
Sbjct: 414 MEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPP 473
Query: 612 PSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDI 671
L +DL+ A +A+G YL IHRD+AARN L++ V KI DFG+ARD+
Sbjct: 474 EEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVT---EDNVMKIADFGLARDV 530
Query: 672 YRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQE 731
+ YY++ LPVKWM PEA + ++T ++D WSFGVLLWEIF+LG PYPG +E
Sbjct: 531 HNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEE 590
Query: 732 VLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASI---LERLQYCTQDPDVLN 788
+ + G RMD P C +Y IM +CW P RP+F + L+R+ T + L+
Sbjct: 591 LFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLD 650
Query: 789 SLLPMEL----GPTPEEEGTSGLGNRSLECLRPPQP 820
P E G +SG + L PP P
Sbjct: 651 LSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 686
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 204 bits (520), Expect = 2e-52
Identities = 120/336 (35%), Positives = 176/336 (52%), Gaps = 22/336 (6%)
Query: 504 EVSPANVTLLRALGHGAFGEVYEGLVIGLPGD--SSPLQVAIKTLPELCSPQDELDFLME 561
E+S A +TL + LG G FG+V IG+ D + P+ VA+K L + + +D D + E
Sbjct: 466 ELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSE 525
Query: 562 ALIISKF-RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPH---------LGQ 611
++ +H+NI+ +G + P +L+E + G+++ FLR RP
Sbjct: 526 MEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPP 585
Query: 612 PSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDI 671
L +DL+ A +A+G YL IHRD+AARN L++ V KI DFG+ARD+
Sbjct: 586 EEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVT---EDNVMKIADFGLARDV 642
Query: 672 YRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQE 731
+ YY++ LPVKWM PEA + ++T ++D WSFGVLLWEIF+LG PYPG +E
Sbjct: 643 HNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEE 702
Query: 732 VLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASI---LERLQYCTQDPDVLN 788
+ + G RMD P C +Y IM +CW P RP+F + L+R+ T + L+
Sbjct: 703 LFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLD 762
Query: 789 SLLPMEL----GPTPEEEGTSGLGNRSLECLRPPQP 820
P E G +SG + L PP P
Sbjct: 763 LSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 798
>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
isoform 1 [Homo sapiens]
Length = 937
Score = 202 bits (515), Expect = 8e-52
Identities = 114/285 (40%), Positives = 159/285 (55%), Gaps = 14/285 (4%)
Query: 504 EVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEAL 563
E+ + V + LG AFG++Y+G + LPG VAIKTL + +PQ +F EA
Sbjct: 467 ELPLSAVRFMEELGECAFGKIYKGHLY-LPGMDHAQLVAIKTLKDYNNPQQWTEFQQEAS 525
Query: 564 IISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQ----------PS 613
++++ H NIV +G + P +L E ++ GD+ FL PH S
Sbjct: 526 LMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKS 585
Query: 614 PLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYR 673
L D L +A IA G YL + F+H+D+AARN L+ G KI D G++R+IY
Sbjct: 586 SLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILI---GEQLHVKISDLGLSREIYS 642
Query: 674 ASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL 733
A YYR ++LLP++WMPPEA + G F+S +D WSFGV+LWEIFS G PY G +NQEV+
Sbjct: 643 ADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVI 702
Query: 734 DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 778
+ V + CP +Y +MT+CW P RP F I RL+
Sbjct: 703 EMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLR 747
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 199 bits (507), Expect = 7e-51
Identities = 107/274 (39%), Positives = 156/274 (56%), Gaps = 8/274 (2%)
Query: 513 LRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQN 572
+ LG FGEV+ GL + V +K+L Q +LDF E + K H N
Sbjct: 799 ITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNHAN 857
Query: 573 IVRCVGLSLRATPRLILLELMSGGDMKSFLR--HSRPHLGQPSPLVMRDLLQLAQDIAQG 630
+VR +GL A P ++LE + GD+K FLR S+ + PL + + L +A G
Sbjct: 858 VVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALG 917
Query: 631 CHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWM 690
+L N F+H+D+AARNCL+S R K+ G+++D+Y + YY +A +P++WM
Sbjct: 918 MEHLSNNRFVHKDLAARNCLVSA---QRQVKVSALGLSKDVYNSEYYHFR-QAWVPLRWM 973
Query: 691 PPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL-DFVVGGGRMDPPRGCP 749
PEA LEG F++K+D W+FGVL+WE+F+ G MP+ G+ + EVL D G R+ P GCP
Sbjct: 974 SPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCP 1033
Query: 750 GPVYRIMTQCWQHEPELRPSFASILERLQYCTQD 783
+YR+M +CW P+ RPSF+ I L T D
Sbjct: 1034 SKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1067
>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
sapiens]
Length = 1014
Score = 199 bits (507), Expect = 7e-51
Identities = 107/274 (39%), Positives = 156/274 (56%), Gaps = 8/274 (2%)
Query: 513 LRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQN 572
+ LG FGEV+ GL + V +K+L Q +LDF E + K H N
Sbjct: 743 ITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNHAN 801
Query: 573 IVRCVGLSLRATPRLILLELMSGGDMKSFLR--HSRPHLGQPSPLVMRDLLQLAQDIAQG 630
+VR +GL A P ++LE + GD+K FLR S+ + PL + + L +A G
Sbjct: 802 VVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALG 861
Query: 631 CHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWM 690
+L N F+H+D+AARNCL+S R K+ G+++D+Y + YY +A +P++WM
Sbjct: 862 MEHLSNNRFVHKDLAARNCLVSA---QRQVKVSALGLSKDVYNSEYYHFR-QAWVPLRWM 917
Query: 691 PPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL-DFVVGGGRMDPPRGCP 749
PEA LEG F++K+D W+FGVL+WE+F+ G MP+ G+ + EVL D G R+ P GCP
Sbjct: 918 SPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCP 977
Query: 750 GPVYRIMTQCWQHEPELRPSFASILERLQYCTQD 783
+YR+M +CW P+ RPSF+ I L T D
Sbjct: 978 SKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1011
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
[Homo sapiens]
Length = 940
Score = 199 bits (507), Expect = 7e-51
Identities = 107/274 (39%), Positives = 156/274 (56%), Gaps = 8/274 (2%)
Query: 513 LRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQN 572
+ LG FGEV+ GL + V +K+L Q +LDF E + K H N
Sbjct: 669 ITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNHAN 727
Query: 573 IVRCVGLSLRATPRLILLELMSGGDMKSFLR--HSRPHLGQPSPLVMRDLLQLAQDIAQG 630
+VR +GL A P ++LE + GD+K FLR S+ + PL + + L +A G
Sbjct: 728 VVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALG 787
Query: 631 CHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWM 690
+L N F+H+D+AARNCL+S R K+ G+++D+Y + YY +A +P++WM
Sbjct: 788 MEHLSNNRFVHKDLAARNCLVSA---QRQVKVSALGLSKDVYNSEYYHFR-QAWVPLRWM 843
Query: 691 PPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL-DFVVGGGRMDPPRGCP 749
PEA LEG F++K+D W+FGVL+WE+F+ G MP+ G+ + EVL D G R+ P GCP
Sbjct: 844 SPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCP 903
Query: 750 GPVYRIMTQCWQHEPELRPSFASILERLQYCTQD 783
+YR+M +CW P+ RPSF+ I L T D
Sbjct: 904 SKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 937
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.138 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,122,824
Number of Sequences: 37866
Number of extensions: 2580127
Number of successful extensions: 29419
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 578
Number of HSP's successfully gapped in prelim test: 856
Number of HSP's that attempted gapping in prelim test: 14827
Number of HSP's gapped (non-prelim): 7614
length of query: 864
length of database: 18,247,518
effective HSP length: 111
effective length of query: 753
effective length of database: 14,044,392
effective search space: 10575427176
effective search space used: 10575427176
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.