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Search of human proteins with 41352712
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41352712 inhibitor of nuclear factor kappa B kinase beta
subunit [Homo sapiens]
(756 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41352712 inhibitor of nuclear factor kappa B kinase beta subu... 1521 0.0
gi|62241001 conserved helix-loop-helix ubiquitous kinase [Homo s... 731 0.0
gi|7661946 IKK-related kinase epsilon [Homo sapiens] 148 2e-35
gi|7019547 TANK-binding kinase 1 [Homo sapiens] 136 8e-32
gi|217330559 unc-51-like kinase 2 [Homo sapiens] 132 9e-31
gi|217330557 unc-51-like kinase 2 [Homo sapiens] 132 9e-31
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 130 6e-30
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 118 2e-26
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 118 2e-26
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 116 9e-26
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 116 9e-26
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 112 1e-24
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 112 1e-24
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 111 3e-24
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 110 4e-24
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 110 4e-24
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 110 4e-24
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 110 4e-24
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 109 1e-23
gi|4557511 death-associated protein kinase 3 [Homo sapiens] 108 2e-23
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 108 2e-23
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 106 9e-23
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 106 9e-23
gi|14670383 death-associated kinase 2 [Homo sapiens] 106 9e-23
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 105 2e-22
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 105 2e-22
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 104 3e-22
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 104 3e-22
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 104 3e-22
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 104 3e-22
>gi|41352712 inhibitor of nuclear factor kappa B kinase beta subunit
[Homo sapiens]
Length = 756
Score = 1521 bits (3938), Expect = 0.0
Identities = 756/756 (100%), Positives = 756/756 (100%)
Query: 1 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL 60
MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
Sbjct: 1 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL 60
Query: 61 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG 120
EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
Sbjct: 61 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG 120
Query: 121 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT 180
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
Sbjct: 121 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT 180
Query: 181 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE 240
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
Sbjct: 181 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE 240
Query: 241 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF 300
VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
Sbjct: 241 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF 300
Query: 301 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA 360
KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
Sbjct: 301 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA 360
Query: 361 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN 420
LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
Sbjct: 361 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN 420
Query: 421 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK 480
LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
Sbjct: 421 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK 480
Query: 481 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL 540
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
Sbjct: 481 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL 540
Query: 541 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS 600
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
Sbjct: 541 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS 600
Query: 601 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI 660
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
Sbjct: 601 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI 660
Query: 661 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE 720
ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
Sbjct: 661 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE 720
Query: 721 NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS 756
NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
Sbjct: 721 NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS 756
>gi|62241001 conserved helix-loop-helix ubiquitous kinase [Homo
sapiens]
Length = 745
Score = 731 bits (1887), Expect = 0.0
Identities = 383/749 (51%), Positives = 510/749 (68%), Gaps = 13/749 (1%)
Query: 1 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL 60
M P L G WEM+ERLGTGGFGNV + ++E +IAIK CR ELS +NRERWC
Sbjct: 1 MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH 60
Query: 61 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG 120
EIQIM++L H NVV A DVPE + N+ +D+PLLAMEYC GGDLRK LN+ ENCCGL+E
Sbjct: 61 EIQIMKKLNHANVVKACDVPEEL-NILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKES 119
Query: 121 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT 180
IL+LLSDI S +RYLHEN+IIHRDLKPENIVLQ ++IHKIIDLGYAK++DQGSLCT
Sbjct: 120 QILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCT 179
Query: 181 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE 240
SFVGTLQYLAPEL E + YT TVDYWSFGT+ FECI G+RPFL + QP WH K+++K
Sbjct: 180 SFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDP 239
Query: 241 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRG--TDPTYGPNG 298
I E+++G V+FSS LP PN+L S++ E +E WLQLML W P+QRG D T
Sbjct: 240 KCIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPR 299
Query: 299 CFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAG 358
CF +D ILNLK+VHILNM + I ++ + DESL SL++RI+++TGI QELL E G
Sbjct: 300 CFVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETG 359
Query: 359 LALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPK 418
++L P KPA+QC+ DG D +V+LFD SK YE + R + V+ I+Q+ K
Sbjct: 360 ISLDPRKPASQCVLDGV----RGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSK 415
Query: 419 RNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQ 478
L QLRKVW + H + LKED +RL QGQRAAM++LLR N+ L+KMKN++ S SQQ
Sbjct: 416 IQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQ 475
Query: 479 LKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMM 538
LKAKL+FF SIQ+DLE+YSEQ +GI+S+K+L AW+EME+ + L +++M
Sbjct: 476 LKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIM 535
Query: 539 ALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAI 598
+L +I++LQ+SP GR+QG ++ LE++A +LY++L+ +P D + DS EMV++++ +
Sbjct: 536 SLHAEIMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSD-HSYSDSTEMVKIIVHTV 594
Query: 599 QSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLL 658
QS ++ ++ ++ LSK + CKQK ++LLPKVE +S + E + TV+ +Q KRQKE+W+LL
Sbjct: 595 QSQDRVLKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLL 654
Query: 659 KIAC--SKVRGPVSGSPDSMNASRLS---QPGQLMSQPSTASNSLPEPAKKSEELVAEAH 713
KIAC S R V S + + S P S + P+ + S +++ E
Sbjct: 655 KIACTQSSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENL 714
Query: 714 NLCTLLENAIQDTVREQDQSFTALDWSWL 742
N L I + EQ S LDWSWL
Sbjct: 715 NCLGHLSTIIHEANEEQGNSMMNLDWSWL 743
>gi|7661946 IKK-related kinase epsilon [Homo sapiens]
Length = 716
Score = 148 bits (373), Expect = 2e-35
Identities = 104/372 (27%), Positives = 169/372 (45%), Gaps = 23/372 (6%)
Query: 15 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 74
W + LG G +V + N+++GE +A+K R RE E +++R+L H N+V
Sbjct: 9 WHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIV 68
Query: 75 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 134
V E + +L MEYC G L L EN GL E L +L + + +
Sbjct: 69 KLFAVEE----TGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMN 124
Query: 135 YLHENRIIHRDLKPENIVLQQGEQ-RLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 193
+L EN I+HRD+KP NI+ GE+ + I+K+ D G A+ELD S GT +YL P++
Sbjct: 125 HLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDM 184
Query: 194 LE--------QQKYTVTVDYWSFGTLAFECITGFRPFLPNWQP-----VQWHSKVRQKSE 240
E Q+ + VTVD WS G + TG PF+P P + + + +
Sbjct: 185 YERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAG 244
Query: 241 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF 300
NG +++S +LP L+ L +L L +L + +G + F
Sbjct: 245 AIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAK-----CWGFDQFF 299
Query: 301 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA 360
DIL +VH+ ++ +H + ++ + + + T + QE L E L
Sbjct: 300 AETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLC 359
Query: 361 LIPDKPATQCIS 372
++ + Q I+
Sbjct: 360 VLEPSVSAQHIA 371
>gi|7019547 TANK-binding kinase 1 [Homo sapiens]
Length = 729
Score = 136 bits (342), Expect = 8e-32
Identities = 100/356 (28%), Positives = 160/356 (44%), Gaps = 23/356 (6%)
Query: 15 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 74
W + + LG G NV R +++TG+ AIK R + E +++++L H N+V
Sbjct: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68
Query: 75 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 134
+ E +L ME+C G L L + N GL E L +L D+ +
Sbjct: 69 KLFAIEEETTTRHK----VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124
Query: 135 YLHENRIIHRDLKPENIVLQQGEQ-RLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 193
+L EN I+HRD+KP NI+ GE + ++K+ D G A+EL+ S GT +YL P++
Sbjct: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184
Query: 194 LE--------QQKYTVTVDYWSFGTLAFECITGFRPFLPNWQP-----VQWHSKVRQKSE 240
E Q+KY TVD WS G + TG PF P P V + + S
Sbjct: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244
Query: 241 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF 300
V + NG + +S +P +L+ L L L +L + + +G + F
Sbjct: 245 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANIL-----EADQEKCWGFDQFF 299
Query: 301 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQE 356
DIL+ ++H+ ++ T H + + + + T I +QEL+ E
Sbjct: 300 AETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYE 355
>gi|217330559 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 132 bits (333), Expect = 9e-31
Identities = 80/218 (36%), Positives = 115/218 (52%), Gaps = 16/218 (7%)
Query: 15 WEMKERLGTGGFGNVIRW-HNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNV 73
+ ++ +G G F V R H Q+T ++AIK ++ +++ EI+I++ L H N+
Sbjct: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENI 68
Query: 74 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASAL 133
VA DV E PN + L MEYC GGDL YL L E I L IA+A+
Sbjct: 69 VALYDVQE-----LPNSV-FLVMEYCNGGDLADYLQAKGT---LSEDTIRVFLHQIAAAM 119
Query: 134 RYLHENRIIHRDLKPENIVLQQGEQR------LIHKIIDLGYAKELDQGSLCTSFVGTLQ 187
R LH IIHRDLKP+NI+L +R + KI D G+A+ L + + G+
Sbjct: 120 RILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPM 179
Query: 188 YLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPN 225
Y+APE++ Q Y D WS GT+ ++C+ G PF N
Sbjct: 180 YMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQAN 217
>gi|217330557 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 132 bits (333), Expect = 9e-31
Identities = 80/218 (36%), Positives = 115/218 (52%), Gaps = 16/218 (7%)
Query: 15 WEMKERLGTGGFGNVIRW-HNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNV 73
+ ++ +G G F V R H Q+T ++AIK ++ +++ EI+I++ L H N+
Sbjct: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENI 68
Query: 74 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASAL 133
VA DV E PN + L MEYC GGDL YL L E I L IA+A+
Sbjct: 69 VALYDVQE-----LPNSV-FLVMEYCNGGDLADYLQAKGT---LSEDTIRVFLHQIAAAM 119
Query: 134 RYLHENRIIHRDLKPENIVLQQGEQR------LIHKIIDLGYAKELDQGSLCTSFVGTLQ 187
R LH IIHRDLKP+NI+L +R + KI D G+A+ L + + G+
Sbjct: 120 RILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPM 179
Query: 188 YLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPN 225
Y+APE++ Q Y D WS GT+ ++C+ G PF N
Sbjct: 180 YMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQAN 217
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 130 bits (326), Expect = 6e-30
Identities = 78/223 (34%), Positives = 117/223 (52%), Gaps = 18/223 (8%)
Query: 9 TQTCGAWEM--KERLGTGGFGNVIRWHNQETGE-QIAIKQCRQELSPRNRERWCLEIQIM 65
T+T G +E K+ +G G F V + ++E + ++A+K ++ +++ EI+I+
Sbjct: 8 TETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKIL 67
Query: 66 RRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTL 125
+ L H N+VA D E ++ L MEYC GGDL YL+ L E I
Sbjct: 68 KELKHENIVALYDFQEMANSV------YLVMEYCNGGDLADYLHAMRT---LSEDTIRLF 118
Query: 126 LSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIH------KIIDLGYAKELDQGSLC 179
L IA A+R LH IIHRDLKP+NI+L R + KI D G+A+ L +
Sbjct: 119 LQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMA 178
Query: 180 TSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPF 222
+ G+ Y+APE++ Q Y D WS GT+ ++C+TG PF
Sbjct: 179 ATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPF 221
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 118 bits (295), Expect = 2e-26
Identities = 77/248 (31%), Positives = 125/248 (50%), Gaps = 12/248 (4%)
Query: 8 TTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL-EIQIMR 66
T +E++ERLG+G F V+ + + +A+K C + + R +E EI ++R
Sbjct: 25 TEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALK-CIPKKALRGKEALVENEIAVLR 83
Query: 67 RLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLL 126
R++HPN+VA DV E +L LAME GG+L ++ E L+
Sbjct: 84 RISHPNIVALEDVHESPSHL------YLAMELVTGGEL---FDRIMERGSYTEKDASHLV 134
Query: 127 SDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTL 186
+ A+ YLH I+HRDLKPEN++ + + D G +K + G++ + GT
Sbjct: 135 GQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSK-IQAGNMLGTACGTP 193
Query: 187 QYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVS 246
Y+APELLEQ+ Y VD W+ G +++ + G+ PF P + +R E D
Sbjct: 194 GYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFW 253
Query: 247 EDLNGTVK 254
+D++ + K
Sbjct: 254 DDISESAK 261
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 118 bits (295), Expect = 2e-26
Identities = 77/248 (31%), Positives = 125/248 (50%), Gaps = 12/248 (4%)
Query: 8 TTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL-EIQIMR 66
T +E++ERLG+G F V+ + + +A+K C + + R +E EI ++R
Sbjct: 91 TEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALK-CIPKKALRGKEALVENEIAVLR 149
Query: 67 RLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLL 126
R++HPN+VA DV E +L LAME GG+L ++ E L+
Sbjct: 150 RISHPNIVALEDVHESPSHL------YLAMELVTGGEL---FDRIMERGSYTEKDASHLV 200
Query: 127 SDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTL 186
+ A+ YLH I+HRDLKPEN++ + + D G +K + G++ + GT
Sbjct: 201 GQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSK-IQAGNMLGTACGTP 259
Query: 187 QYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVS 246
Y+APELLEQ+ Y VD W+ G +++ + G+ PF P + +R E D
Sbjct: 260 GYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFW 319
Query: 247 EDLNGTVK 254
+D++ + K
Sbjct: 320 DDISESAK 327
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 116 bits (290), Expect = 9e-26
Identities = 73/240 (30%), Positives = 120/240 (50%), Gaps = 9/240 (3%)
Query: 15 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 74
+E KE LGTG F V+ + TG+ A+K ++ EI ++R++ H N+V
Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82
Query: 75 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 134
A D+ E +PN L L M+ GG+L ++ E TL+ + A+
Sbjct: 83 ALEDIYE-----SPNHL-YLVMQLVSGGEL---FDRIVEKGFYTEKDASTLIRQVLDAVY 133
Query: 135 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELL 194
YLH I+HRDLKPEN++ ++ I D G +K +G + ++ GT Y+APE+L
Sbjct: 134 YLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVL 193
Query: 195 EQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVK 254
Q+ Y+ VD WS G +A+ + G+ PF + ++ + E D +D++ + K
Sbjct: 194 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAK 253
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 116 bits (290), Expect = 9e-26
Identities = 73/240 (30%), Positives = 120/240 (50%), Gaps = 9/240 (3%)
Query: 15 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 74
+E KE LGTG F V+ + TG+ A+K ++ EI ++R++ H N+V
Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82
Query: 75 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 134
A D+ E +PN L L M+ GG+L ++ E TL+ + A+
Sbjct: 83 ALEDIYE-----SPNHL-YLVMQLVSGGEL---FDRIVEKGFYTEKDASTLIRQVLDAVY 133
Query: 135 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELL 194
YLH I+HRDLKPEN++ ++ I D G +K +G + ++ GT Y+APE+L
Sbjct: 134 YLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVL 193
Query: 195 EQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVK 254
Q+ Y+ VD WS G +A+ + G+ PF + ++ + E D +D++ + K
Sbjct: 194 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAK 253
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 112 bits (281), Expect = 1e-24
Identities = 71/240 (29%), Positives = 121/240 (50%), Gaps = 9/240 (3%)
Query: 15 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 74
++ ++ LGTG F VI ++ T + +AIK +E EI ++ ++ HPN+V
Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIV 79
Query: 75 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 134
A D+ E +L L M+ GG+L ++ E L+ + A++
Sbjct: 80 ALDDIYESGGHL------YLIMQLVSGGEL---FDRIVEKGFYTERDASRLIFQVLDAVK 130
Query: 135 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELL 194
YLH+ I+HRDLKPEN++ ++ I D G +K D GS+ ++ GT Y+APE+L
Sbjct: 131 YLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVL 190
Query: 195 EQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVK 254
Q+ Y+ VD WS G +A+ + G+ PF + ++ + E D +D++ + K
Sbjct: 191 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAK 250
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 112 bits (280), Expect = 1e-24
Identities = 68/208 (32%), Positives = 114/208 (54%), Gaps = 12/208 (5%)
Query: 17 MKERLGTGGFGNVIR-WHNQETGEQIAIK-QCRQELSPRNRERWCLEIQIMRRLTHPNVV 74
+ ERLG+G + V + + ++T E +AIK ++ L+ + E EI+I++ + HP++V
Sbjct: 16 LTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIV 75
Query: 75 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 134
+D N+ L ME+C GGDL ++++ L E + +ASAL+
Sbjct: 76 QLKDFQWDSDNI------YLIMEFCAGGDLSRFIHTRRI---LPEKVARVFMQQLASALQ 126
Query: 135 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELL 194
+LHE I H DLKP+NI+L E+ + K+ D G+A+ + G+ Y+APE++
Sbjct: 127 FLHERNISHLDLKPQNILLSSLEKPHL-KLADFGFAQHMSPWDEKHVLRGSPLYMAPEMV 185
Query: 195 EQQKYTVTVDYWSFGTLAFECITGFRPF 222
Q++Y VD WS G + +E + G PF
Sbjct: 186 CQRQYDARVDLWSMGVILYEALFGQPPF 213
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 111 bits (277), Expect = 3e-24
Identities = 69/212 (32%), Positives = 113/212 (53%), Gaps = 14/212 (6%)
Query: 13 GAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCLEIQIMRRLTHP 71
G + +++ +G G F V + TG ++A+K + +L+P + ++ E++IM+ L HP
Sbjct: 58 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 117
Query: 72 NVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIAS 131
N+V +V E + L L MEY GG++ YL ++E I S
Sbjct: 118 NIVKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVS 168
Query: 132 ALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAP 191
A++Y H+ I+HRDLK EN++L G+ + KI D G++ E G+ +F G+ Y AP
Sbjct: 169 AVQYCHQKYIVHRDLKAENLLL-DGDMNI--KIADFGFSNEFTVGNKLDTFCGSPPYAAP 225
Query: 192 ELLEQQKYT-VTVDYWSFGTLAFECITGFRPF 222
EL + +KY VD WS G + + ++G PF
Sbjct: 226 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 257
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 110 bits (276), Expect = 4e-24
Identities = 70/212 (33%), Positives = 112/212 (52%), Gaps = 14/212 (6%)
Query: 13 GAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCLEIQIMRRLTHP 71
G + + + +G G F V + TG ++AIK + +L+P + ++ E++IM+ L HP
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 72 NVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIAS 131
N+V +V E + L L MEY GG++ YL ++E + I S
Sbjct: 114 NIVKLFEVIETEKTL------YLIMEYASGGEVFDYLVAHGR---MKEKEARSKFRQIVS 164
Query: 132 ALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAP 191
A++Y H+ RI+HRDLK EN++L + + KI D G++ E G +F G+ Y AP
Sbjct: 165 AVQYCHQKRIVHRDLKAENLLL---DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAP 221
Query: 192 ELLEQQKYT-VTVDYWSFGTLAFECITGFRPF 222
EL + +KY VD WS G + + ++G PF
Sbjct: 222 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 253
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 110 bits (276), Expect = 4e-24
Identities = 70/212 (33%), Positives = 112/212 (52%), Gaps = 14/212 (6%)
Query: 13 GAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCLEIQIMRRLTHP 71
G + + + +G G F V + TG ++AIK + +L+P + ++ E++IM+ L HP
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 72 NVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIAS 131
N+V +V E + L L MEY GG++ YL ++E + I S
Sbjct: 114 NIVKLFEVIETEKTL------YLIMEYASGGEVFDYLVAHGR---MKEKEARSKFRQIVS 164
Query: 132 ALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAP 191
A++Y H+ RI+HRDLK EN++L + + KI D G++ E G +F G+ Y AP
Sbjct: 165 AVQYCHQKRIVHRDLKAENLLL---DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAP 221
Query: 192 ELLEQQKYT-VTVDYWSFGTLAFECITGFRPF 222
EL + +KY VD WS G + + ++G PF
Sbjct: 222 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 253
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 110 bits (276), Expect = 4e-24
Identities = 70/212 (33%), Positives = 112/212 (52%), Gaps = 14/212 (6%)
Query: 13 GAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCLEIQIMRRLTHP 71
G + + + +G G F V + TG ++AIK + +L+P + ++ E++IM+ L HP
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 72 NVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIAS 131
N+V +V E + L L MEY GG++ YL ++E + I S
Sbjct: 114 NIVKLFEVIETEKTL------YLIMEYASGGEVFDYLVAHGR---MKEKEARSKFRQIVS 164
Query: 132 ALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAP 191
A++Y H+ RI+HRDLK EN++L + + KI D G++ E G +F G+ Y AP
Sbjct: 165 AVQYCHQKRIVHRDLKAENLLL---DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAP 221
Query: 192 ELLEQQKYT-VTVDYWSFGTLAFECITGFRPF 222
EL + +KY VD WS G + + ++G PF
Sbjct: 222 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 253
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 110 bits (276), Expect = 4e-24
Identities = 70/212 (33%), Positives = 112/212 (52%), Gaps = 14/212 (6%)
Query: 13 GAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCLEIQIMRRLTHP 71
G + + + +G G F V + TG ++AIK + +L+P + ++ E++IM+ L HP
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 72 NVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIAS 131
N+V +V E + L L MEY GG++ YL ++E + I S
Sbjct: 114 NIVKLFEVIETEKTL------YLIMEYASGGEVFDYLVAHGR---MKEKEARSKFRQIVS 164
Query: 132 ALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAP 191
A++Y H+ RI+HRDLK EN++L + + KI D G++ E G +F G+ Y AP
Sbjct: 165 AVQYCHQKRIVHRDLKAENLLL---DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAP 221
Query: 192 ELLEQQKYT-VTVDYWSFGTLAFECITGFRPF 222
EL + +KY VD WS G + + ++G PF
Sbjct: 222 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 253
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 109 bits (272), Expect = 1e-23
Identities = 75/236 (31%), Positives = 120/236 (50%), Gaps = 31/236 (13%)
Query: 15 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQC----RQELSPRNRERWCLEIQIMRRLTH 70
+ + E +G G FG V + + + + +A+K R E RN +R EI+IMR L H
Sbjct: 4 YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQR---EIEIMRGLRH 60
Query: 71 PNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIA 130
PN+V D E + + ++ +Y +G + E+ L E + + + +
Sbjct: 61 PNIVHMLDSFETDKEV------VVVTDYAEG----ELFQILEDDGKLPEDQVQAIAAQLV 110
Query: 131 SALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSL-CTSFVGTLQYL 189
SAL YLH +RI+HRD+KP+NI+L +G K+ D G+A+ + ++ TS GT Y+
Sbjct: 111 SALYYLHSHRILHRDMKPQNILLAKGGG---IKLCDFGFARAMSTNTMVLTSIKGTPLYM 167
Query: 190 APELLEQQKYTVTVDYWSFGTLAFECITGFRPF----------LPNWQPVQWHSKV 235
+PEL+E++ Y T D WS G + +E G PF L PV+W S +
Sbjct: 168 SPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTI 223
>gi|4557511 death-associated protein kinase 3 [Homo sapiens]
Length = 454
Score = 108 bits (270), Expect = 2e-23
Identities = 70/215 (32%), Positives = 112/215 (52%), Gaps = 15/215 (6%)
Query: 15 WEMKERLGTGGFGNVIRWHNQETGEQIA---IKQCRQELSPR--NRERWCLEIQIMRRLT 69
+EM E LG+G F V + + TG++ A IK+ R S R +RE E+ I+R +
Sbjct: 13 YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIR 72
Query: 70 HPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDI 129
HPN++ D+ E ++ +L +E GG+L +L + E+ L E L I
Sbjct: 73 HPNIITLHDIFENKTDV------VLILELVSGGELFDFLAEKES---LTEDEATQFLKQI 123
Query: 130 ASALRYLHENRIIHRDLKPENIVL-QQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQY 188
+ YLH RI H DLKPENI+L + K+ID G A +++ G+ + GT ++
Sbjct: 124 LDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEF 183
Query: 189 LAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFL 223
+APE++ + + D WS G + + ++G PFL
Sbjct: 184 VAPEIVNYEPLGLEADMWSIGVITYILLSGASPFL 218
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 108 bits (269), Expect = 2e-23
Identities = 70/212 (33%), Positives = 108/212 (50%), Gaps = 14/212 (6%)
Query: 13 GAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCLEIQIMRRLTHP 71
G + + +G G F V + TG ++AIK + +L+P + ++ E++IM+ L HP
Sbjct: 57 GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHP 116
Query: 72 NVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIAS 131
N+V +V E + L L MEY G++ YL ++E I S
Sbjct: 117 NIVKLFEVIETEKTL------YLVMEYASAGEVFDYLVSHGR---MKEKEARAKFRQIVS 167
Query: 132 ALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAP 191
A+ Y H+ I+HRDLK EN++L E + KI D G++ E GS +F G+ Y AP
Sbjct: 168 AVHYCHQKNIVHRDLKAENLLL-DAEANI--KIADFGFSNEFTLGSKLDTFCGSPPYAAP 224
Query: 192 ELLEQQKYT-VTVDYWSFGTLAFECITGFRPF 222
EL + +KY VD WS G + + ++G PF
Sbjct: 225 ELFQGKKYDGPEVDIWSLGVILYTLVSGSLPF 256
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 106 bits (264), Expect = 9e-23
Identities = 73/222 (32%), Positives = 112/222 (50%), Gaps = 32/222 (14%)
Query: 17 MKERLGTGGFGNVIRWHNQETGEQIAIK----------QCRQELSPRNRERWCLEIQIMR 66
M + LG+G G V ++T +++AIK R+ N E EI+I++
Sbjct: 265 MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVET---EIEILK 321
Query: 67 RLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCG---LREGAIL 123
+L HP ++ ++N + + +E +GG+L F+ G L+E
Sbjct: 322 KLNHPCIIK-------IKNFFDAEDYYIVLELMEGGEL------FDKVVGNKRLKEATCK 368
Query: 124 TLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFV 183
+ A++YLHEN IIHRDLKPEN++L E+ + KI D G++K L + SL +
Sbjct: 369 LYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLC 428
Query: 184 GTLQYLAPELLEQ---QKYTVTVDYWSFGTLAFECITGFRPF 222
GT YLAPE+L Y VD WS G + F C++G+ PF
Sbjct: 429 GTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF 470
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 106 bits (264), Expect = 9e-23
Identities = 73/222 (32%), Positives = 112/222 (50%), Gaps = 32/222 (14%)
Query: 17 MKERLGTGGFGNVIRWHNQETGEQIAIK----------QCRQELSPRNRERWCLEIQIMR 66
M + LG+G G V ++T +++AIK R+ N E EI+I++
Sbjct: 222 MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVET---EIEILK 278
Query: 67 RLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCG---LREGAIL 123
+L HP ++ ++N + + +E +GG+L F+ G L+E
Sbjct: 279 KLNHPCIIK-------IKNFFDAEDYYIVLELMEGGEL------FDKVVGNKRLKEATCK 325
Query: 124 TLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFV 183
+ A++YLHEN IIHRDLKPEN++L E+ + KI D G++K L + SL +
Sbjct: 326 LYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLC 385
Query: 184 GTLQYLAPELLEQ---QKYTVTVDYWSFGTLAFECITGFRPF 222
GT YLAPE+L Y VD WS G + F C++G+ PF
Sbjct: 386 GTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF 427
>gi|14670383 death-associated kinase 2 [Homo sapiens]
Length = 370
Score = 106 bits (264), Expect = 9e-23
Identities = 68/215 (31%), Positives = 109/215 (50%), Gaps = 15/215 (6%)
Query: 15 WEMKERLGTGGFGNVIRWHNQETGEQIAIK-----QCRQELSPRNRERWCLEIQIMRRLT 69
+++ E LG+G F V + + TG + A K Q R +RE E+ I+R++
Sbjct: 23 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 82
Query: 70 HPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDI 129
H NV+ DV E ++ +L +E GG+L +L Q E+ L E + + I
Sbjct: 83 HHNVITLHDVYENRTDV------VLILELVSGGELFDFLAQKES---LSEEEATSFIKQI 133
Query: 130 ASALRYLHENRIIHRDLKPENIVLQQGEQRLIH-KIIDLGYAKELDQGSLCTSFVGTLQY 188
+ YLH +I H DLKPENI+L + H K+ID G A E++ G + GT ++
Sbjct: 134 LDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEF 193
Query: 189 LAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFL 223
+APE++ + + D WS G + + ++G PFL
Sbjct: 194 VAPEIVNYEPLGLEADMWSIGVITYILLSGASPFL 228
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 105 bits (262), Expect = 2e-22
Identities = 69/211 (32%), Positives = 106/211 (50%), Gaps = 16/211 (7%)
Query: 15 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL--EIQIMRRLTHPN 72
+E E LG G +G V + + +G +AIK R++ ++ + EI+IM L HP+
Sbjct: 53 YEFLETLGKGTYGKVKK-ARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111
Query: 73 VVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASA 132
++A +V E + ++ MEY GDL Y+++ + L E I SA
Sbjct: 112 IIAIHEVFENSSKI------VIVMEYASRGDLYDYISERQQ---LSEREARHFFRQIVSA 162
Query: 133 LRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPE 192
+ Y H+NR++HRDLK ENI+L KI D G + QG +F G+ Y +PE
Sbjct: 163 VHYCHQNRVVHRDLKLENILLDANGN---IKIADFGLSNLYHQGKFLQTFCGSPLYASPE 219
Query: 193 LLEQQKYT-VTVDYWSFGTLAFECITGFRPF 222
++ + YT VD WS G L + + G PF
Sbjct: 220 IVNGKPYTGPEVDSWSLGVLLYILVHGTMPF 250
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 105 bits (262), Expect = 2e-22
Identities = 82/281 (29%), Positives = 135/281 (48%), Gaps = 38/281 (13%)
Query: 4 SPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQ 63
+P+ T + +E LG G FG V+ +QETG A+K N+++ Q
Sbjct: 33 NPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKIL-------NKQKVVKMKQ 85
Query: 64 IMRRLTHPNVVAARDVPEGMQ---NLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG 120
+ L ++ A D P ++ + N L MEY GG++ ++ + E
Sbjct: 86 VEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEM---FSRLQRVGRFSEP 142
Query: 121 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT 180
+ + A++YLH +IHRDLKPEN+++ +Q+ ++ D G+AK + +G T
Sbjct: 143 HACFYAAQVVLAVQYLHSLDLIHRDLKPENLLI---DQQGYLQVTDFGFAKRV-KGRTWT 198
Query: 181 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE 240
GT +YLAPE++ + Y VD+W+ G L +E GF PF + QP+Q + K+
Sbjct: 199 -LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYAD-QPIQIYEKI----- 251
Query: 241 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLML 281
++G V+F P+ L+S L L LQ+ L
Sbjct: 252 --------VSGRVRF------PSKLSSDLKHLLRSLLQVDL 278
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 104 bits (260), Expect = 3e-22
Identities = 67/212 (31%), Positives = 111/212 (52%), Gaps = 14/212 (6%)
Query: 13 GAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCLEIQIMRRLTHP 71
G + + + +G G F V + TG+++A+K + +L+ + ++ E++IM+ L HP
Sbjct: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
Query: 72 NVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIAS 131
N+V +V E + L L MEY GG++ YL ++E I S
Sbjct: 111 NIVKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVS 161
Query: 132 ALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAP 191
A++Y H+ I+HRDLK EN++L + + KI D G++ E G+ +F G+ Y AP
Sbjct: 162 AVQYCHQKFIVHRDLKAENLLL---DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAP 218
Query: 192 ELLEQQKYT-VTVDYWSFGTLAFECITGFRPF 222
EL + +KY VD WS G + + ++G PF
Sbjct: 219 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 250
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 104 bits (260), Expect = 3e-22
Identities = 67/212 (31%), Positives = 111/212 (52%), Gaps = 14/212 (6%)
Query: 13 GAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCLEIQIMRRLTHP 71
G + + + +G G F V + TG+++A+K + +L+ + ++ E++IM+ L HP
Sbjct: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
Query: 72 NVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIAS 131
N+V +V E + L L MEY GG++ YL ++E I S
Sbjct: 111 NIVKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVS 161
Query: 132 ALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAP 191
A++Y H+ I+HRDLK EN++L + + KI D G++ E G+ +F G+ Y AP
Sbjct: 162 AVQYCHQKFIVHRDLKAENLLL---DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAP 218
Query: 192 ELLEQQKYT-VTVDYWSFGTLAFECITGFRPF 222
EL + +KY VD WS G + + ++G PF
Sbjct: 219 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 250
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 104 bits (260), Expect = 3e-22
Identities = 67/212 (31%), Positives = 111/212 (52%), Gaps = 14/212 (6%)
Query: 13 GAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCLEIQIMRRLTHP 71
G + + + +G G F V + TG+++A+K + +L+ + ++ E++IM+ L HP
Sbjct: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
Query: 72 NVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIAS 131
N+V +V E + L L MEY GG++ YL ++E I S
Sbjct: 111 NIVKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVS 161
Query: 132 ALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAP 191
A++Y H+ I+HRDLK EN++L + + KI D G++ E G+ +F G+ Y AP
Sbjct: 162 AVQYCHQKFIVHRDLKAENLLL---DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAP 218
Query: 192 ELLEQQKYT-VTVDYWSFGTLAFECITGFRPF 222
EL + +KY VD WS G + + ++G PF
Sbjct: 219 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 250
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 104 bits (260), Expect = 3e-22
Identities = 67/212 (31%), Positives = 111/212 (52%), Gaps = 14/212 (6%)
Query: 13 GAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCLEIQIMRRLTHP 71
G + + + +G G F V + TG+++A+K + +L+ + ++ E++IM+ L HP
Sbjct: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
Query: 72 NVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIAS 131
N+V +V E + L L MEY GG++ YL ++E I S
Sbjct: 111 NIVKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVS 161
Query: 132 ALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAP 191
A++Y H+ I+HRDLK EN++L + + KI D G++ E G+ +F G+ Y AP
Sbjct: 162 AVQYCHQKFIVHRDLKAENLLL---DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAP 218
Query: 192 ELLEQQKYT-VTVDYWSFGTLAFECITGFRPF 222
EL + +KY VD WS G + + ++G PF
Sbjct: 219 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 250
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,485,261
Number of Sequences: 37866
Number of extensions: 1346942
Number of successful extensions: 6976
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 669
Number of HSP's successfully gapped in prelim test: 301
Number of HSP's that attempted gapping in prelim test: 4486
Number of HSP's gapped (non-prelim): 1408
length of query: 756
length of database: 18,247,518
effective HSP length: 110
effective length of query: 646
effective length of database: 14,082,258
effective search space: 9097138668
effective search space used: 9097138668
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.