Search of human proteins with 41327771

Search of human proteins with 41327771

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo
sapiens]
         (820 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo sapi...  1633   0.0  
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi...   390   e-108
gi|148613856 DEAD box polypeptide 17 isoform 3 [Homo sapiens]         294   3e-79
gi|38201710 DEAD box polypeptide 17 isoform 1 [Homo sapiens]          294   3e-79
gi|222352149 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 [Homo sap...   292   8e-79
gi|21071032 DEAD-box protein abstrakt [Homo sapiens]                  290   5e-78
gi|4758138 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 [Homo sapiens]    285   9e-77
gi|87196351 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3 [Homo...   281   2e-75
gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens]            277   2e-74
gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens]            277   2e-74
gi|169881239 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked ...   277   3e-74
gi|13514809 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked [...   277   3e-74
gi|188035877 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 [Homo sap...   266   4e-71
gi|55749865 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 [Homo sapi...   260   3e-69
gi|20149629 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 isoform 1 ...   253   4e-67
gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3 ...   250   4e-66
gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1 [...   250   4e-66
gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2 ...   250   4e-66
gi|41327776 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 isoform 2 ...   219   1e-56
gi|224593278 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 [Homo sap...   217   4e-56
gi|31542656 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 [Homo sapi...   210   4e-54
gi|38569505 ATP-dependent RNA helicase ROK1 isoform a [Homo sapi...   208   2e-53
gi|51094101 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 2 ...   206   9e-53
gi|164419743 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 1...   206   9e-53
gi|83700235 eukaryotic translation initiation factor 4A2 [Homo s...   202   1e-51
gi|38569503 ATP-dependent RNA helicase ROK1 isoform b [Homo sapi...   200   4e-51
gi|4503529 eukaryotic translation initiation factor 4A isoform 1...   200   5e-51
gi|164664518 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Homo sapi...   195   1e-49
gi|21040371 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 [Homo sapi...   190   4e-48
gi|7661920 eukaryotic translation initiation factor 4A, isoform ...   188   2e-47

>gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo
           sapiens]
          Length = 820

 Score = 1633 bits (4229), Expect = 0.0
 Identities = 820/820 (100%), Positives = 820/820 (100%)

Query: 1   MAGELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSR 60
           MAGELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSR
Sbjct: 1   MAGELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSR 60

Query: 61  SRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRK 120
           SRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRK
Sbjct: 61  SRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRK 120

Query: 121 DRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQE 180
           DRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQE
Sbjct: 121 DRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQE 180

Query: 181 VEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREE 240
           VEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREE
Sbjct: 181 VEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREE 240

Query: 241 KDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLG 300
           KDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLG
Sbjct: 241 KDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLG 300

Query: 301 RGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQK 360
           RGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQK
Sbjct: 301 RGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQK 360

Query: 361 KLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQ 420
           KLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQ
Sbjct: 361 KLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQ 420

Query: 421 AIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTREL 480
           AIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTREL
Sbjct: 421 AIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTREL 480

Query: 481 AQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVL 540
           AQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVL
Sbjct: 481 AQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVL 540

Query: 541 SRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYR 600
           SRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYR
Sbjct: 541 SRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYR 600

Query: 601 QTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILE 660
           QTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILE
Sbjct: 601 QTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILE 660

Query: 661 QGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVA 720
           QGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVA
Sbjct: 661 QGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVA 720

Query: 721 TDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELK 780
           TDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELK
Sbjct: 721 TDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELK 780

Query: 781 QAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA 820
           QAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA
Sbjct: 781 QAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA 820


>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
           sapiens]
          Length = 1031

 Score =  390 bits (1002), Expect = e-108
 Identities = 282/826 (34%), Positives = 415/826 (50%), Gaps = 100/826 (12%)

Query: 9   KDRDASPSKEERKRSRTP-DRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKS 67
           + R  SPS +  KR      R RDRDR R+ S S+D++R RSRDR+R   RSRSR R +S
Sbjct: 21  RSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRSRDRKRL-RRSRSRERDRS 79

Query: 68  AERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSKKD 127
            ER R    R RD+ R R++    R +     +K +K  + S  + K       ++ KKD
Sbjct: 80  RERRR---SRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSKEKTDGGESSKEKKKD 136

Query: 128 EEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQRM 187
           ++D+  +K+  A          + K EEE   + + + K   E    K+  + + E ++ 
Sbjct: 137 KDDKEDEKEKDAGNFD------QNKLEEEMRKRKERVEKWREEQR--KKAMENIGELKKE 188

Query: 188 LEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREEKDKSKEL 247
           +EE ++ +K   +      +DP E E+         E  G E +     + E K++ K+ 
Sbjct: 189 IEEMKQGKKWSLEDDDDDEDDPAEAEKEGN------EMEGEELDPLDAYMEEVKEEVKKF 242

Query: 248 HAIKERYLGGIKKR------RRTRHLNDRKFVFEWDASE----DTSIDYNPLYKERHQVQ 297
           +    +  GG +K+      +    +  +K V + D  +    +   D      E  +V 
Sbjct: 243 NMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYSSEEEEVD 302

Query: 298 LLGRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHW 357
           L                 Q+   G   ++R+ LE  +  +      RK        + + 
Sbjct: 303 L-----------------QTALTGYQTKQRKLLEPVDHGKIEYEPFRK--------NFYV 337

Query: 358 SQKKLDEMTDRDWRIFR-EDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTP 416
              +L +M+  +  +FR E   IT KG   P PI+SW    +   IL  + K GY++PTP
Sbjct: 338 EVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTP 397

Query: 417 IQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAP 476
           IQ QAIP  +  RD+IG+A+TGSGKT AFL+P+   I       R  E  +GP A+I+ P
Sbjct: 398 IQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMD----QRSLEEGEGPIAVIMTP 453

Query: 477 TRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVL--- 533
           TRELA QI +E  KF K LG+R V V GG    +Q   L+ G EI++ TPGR+ID+L   
Sbjct: 454 TRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAAN 513

Query: 534 ENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFE 593
             R   L R TYVVLDEADRM DMGFEP V +I     V N +PD               
Sbjct: 514 SGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRI-----VDNVRPD--------------- 553

Query: 594 SGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRK 653
                 RQTVMF+AT P A+E LAR  L +P  V +G        VEQ+V ++ E +K  
Sbjct: 554 ------RQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFL 607

Query: 654 KLLAIL----EQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSN 709
           KLL +L    E G    +IIFV++++  D L K L +  Y   +LHGG  Q  R+  +++
Sbjct: 608 KLLELLGHYQESG---SVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIIND 664

Query: 710 LKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLT 769
            K G   +LVAT VA RG+D++ + +VVNY    + EDY+HR GRTGRAG  G A TF+T
Sbjct: 665 FKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFIT 724

Query: 770 KEDSAVFYELKQAILESPVSSCPPEL----ANHPDAQHKPGTILTK 811
           ++ +    ++ +A LE   ++ PP+L    ++  D Q   G I+ K
Sbjct: 725 EDQARYAGDIIKA-LELSGTAVPPDLEKLWSDFKDQQKAEGKIIKK 769



 Score = 33.9 bits (76), Expect = 0.63
 Identities = 44/244 (18%), Positives = 89/244 (36%), Gaps = 44/244 (18%)

Query: 129 EDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQRML 188
           E  H  K+  ++  S     ++  +++ ++      S++       +R +   + R R  
Sbjct: 4   ESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRSR 63

Query: 189 EEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREEKDKSKELH 248
           + +R +R + ++  R      +ER R   R+R    +              +  K++   
Sbjct: 64  DRKRLRRSRSRERDRS-----RERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRS 118

Query: 249 AIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGID 308
             KE+  GG   + + +  +D++   E DA    + D N L +E                
Sbjct: 119 RSKEKTDGGESSKEKKKDKDDKEDEKEKDAG---NFDQNKLEEE---------------- 159

Query: 309 LKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLR-----KKEAKQRWDDRHWSQKKLD 363
                          M KR+   EK +EE R + +      KKE ++    + WS +  D
Sbjct: 160 ---------------MRKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDD 204

Query: 364 EMTD 367
           +  D
Sbjct: 205 DDED 208


>gi|148613856 DEAD box polypeptide 17 isoform 3 [Homo sapiens]
          Length = 731

 Score =  294 bits (752), Expect = 3e-79
 Identities = 176/482 (36%), Positives = 271/482 (56%), Gaps = 46/482 (9%)

Query: 330 LEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKI-PN 388
           L +K+ + + L K  K    +  +    +  ++DE+        R    IT +GG + P 
Sbjct: 117 LRKKKWDLSELPKFEKNFYVEHPEVARLTPYEVDEL--------RRKKEITVRGGDVCPK 168

Query: 389 PIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIP 448
           P+ ++  ++ P ++++V+    + EPTPIQ Q  P+ L  RD++G+A+TGSGKT A+L+P
Sbjct: 169 PVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLP 228

Query: 449 LLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISR 508
            +V I   P ++R      GP  ++LAPTRELAQQ+++    +GK   +++  + GG  +
Sbjct: 229 AIVHINHQPYLER----GDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAPK 284

Query: 509 EDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILE 568
             Q   L  G EI IATPGRLID LE+    L RCTY+VLDEADRM+DMGFEP ++KI++
Sbjct: 285 GPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVD 344

Query: 569 HMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVY 628
            +     +PD                     RQT+M++AT P  V +LA  +LR    + 
Sbjct: 345 QI-----RPD---------------------RQTLMWSATWPKEVRQLAEDFLRDYTQIN 378

Query: 629 IGSAG-KPHERVEQKVFLMSESEKRKKLLAILEQGF---DPPIIIFVNQKKGCDVLAKSL 684
           +G+     +  + Q V +  ESEK  KL+ ++E+     +   IIFV  K+ CD L + +
Sbjct: 379 VGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRM 438

Query: 685 EKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKN 744
            + G+ A  +HG K Q +R++ L+  ++G   IL+ATDVA RG+D++DV  V+NYD   +
Sbjct: 439 RRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNS 498

Query: 745 IEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAILESPVSSCPPELANHPDAQHK 804
            EDY+HRIGRT R+   G A TF T  +     EL + +LE    +  P+L    D  H+
Sbjct: 499 SEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIK-VLEEANQAINPKLMQLVD--HR 555

Query: 805 PG 806
            G
Sbjct: 556 GG 557


>gi|38201710 DEAD box polypeptide 17 isoform 1 [Homo sapiens]
          Length = 729

 Score =  294 bits (752), Expect = 3e-79
 Identities = 176/482 (36%), Positives = 271/482 (56%), Gaps = 46/482 (9%)

Query: 330 LEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKI-PN 388
           L +K+ + + L K  K    +  +    +  ++DE+        R    IT +GG + P 
Sbjct: 117 LRKKKWDLSELPKFEKNFYVEHPEVARLTPYEVDEL--------RRKKEITVRGGDVCPK 168

Query: 389 PIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIP 448
           P+ ++  ++ P ++++V+    + EPTPIQ Q  P+ L  RD++G+A+TGSGKT A+L+P
Sbjct: 169 PVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLP 228

Query: 449 LLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISR 508
            +V I   P ++R      GP  ++LAPTRELAQQ+++    +GK   +++  + GG  +
Sbjct: 229 AIVHINHQPYLER----GDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAPK 284

Query: 509 EDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILE 568
             Q   L  G EI IATPGRLID LE+    L RCTY+VLDEADRM+DMGFEP ++KI++
Sbjct: 285 GPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVD 344

Query: 569 HMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVY 628
            +     +PD                     RQT+M++AT P  V +LA  +LR    + 
Sbjct: 345 QI-----RPD---------------------RQTLMWSATWPKEVRQLAEDFLRDYTQIN 378

Query: 629 IGSAG-KPHERVEQKVFLMSESEKRKKLLAILEQGF---DPPIIIFVNQKKGCDVLAKSL 684
           +G+     +  + Q V +  ESEK  KL+ ++E+     +   IIFV  K+ CD L + +
Sbjct: 379 VGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRM 438

Query: 685 EKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKN 744
            + G+ A  +HG K Q +R++ L+  ++G   IL+ATDVA RG+D++DV  V+NYD   +
Sbjct: 439 RRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNS 498

Query: 745 IEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAILESPVSSCPPELANHPDAQHK 804
            EDY+HRIGRT R+   G A TF T  +     EL + +LE    +  P+L    D  H+
Sbjct: 499 SEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIK-VLEEANQAINPKLMQLVD--HR 555

Query: 805 PG 806
            G
Sbjct: 556 GG 557


>gi|222352149 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 [Homo
           sapiens]
          Length = 648

 Score =  292 bits (748), Expect = 8e-79
 Identities = 181/437 (41%), Positives = 260/437 (59%), Gaps = 42/437 (9%)

Query: 370 WRIFREDYSIT---TKGGK---IPNPIRSWKDS-SLPPHILEVIDKCGYKEPTPIQRQAI 422
           WR  +E+++IT    K G+   IPNP  ++ D+    P ++E I K G+++PTPIQ QA 
Sbjct: 216 WR--KENFNITWDDLKDGEKRPIPNPTCTFDDAFQCYPEVMENIKKAGFQKPTPIQSQAW 273

Query: 423 PIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQ 482
           PI LQ  D+IGVA+TG+GKT  +L+P  + +   P +   +     P  ++L PTRELA 
Sbjct: 274 PIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSL---KGQRNRPGMLVLTPTRELAL 330

Query: 483 QIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSR 542
           Q+E E  K+    G+R+V V GG +R++Q   L+ G +I+IATPGRL D+  + ++ L  
Sbjct: 331 QVEGECCKYSYK-GLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKN 389

Query: 543 CTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQT 602
            TY+VLDEAD+M+DMGFEP + KIL  +     +PD                     RQT
Sbjct: 390 ITYLVLDEADKMLDMGFEPQIMKILLDV-----RPD---------------------RQT 423

Query: 603 VMFTATMPPAVERLARSYLRRPAVVYIGSAGKPH-ERVEQKVFLMSESEKRKKLLAILEQ 661
           VM +AT P +V RLA+SYL+ P +VY+G+        V+Q + + +E EK   +   L+ 
Sbjct: 424 VMTSATWPHSVHRLAQSYLKEPMIVYVGTLDLVAVSSVKQNIIVTTEEEKWSHMQTFLQS 483

Query: 662 -GFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVA 720
                 +I+FV++K   D L+  L     +  +LHG + Q  RE AL N K G   IL+A
Sbjct: 484 MSSTDKVIVFVSRKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIA 543

Query: 721 TDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELK 780
           TD+A RG+D+ DV+ V N+D  +NIE+Y+HRIGRTGRAG++GV+IT LT+ D  V  EL 
Sbjct: 544 TDLASRGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAGRTGVSITTLTRNDWRVASELI 603

Query: 781 QAILESPVSSCPPELAN 797
             ILE    S P EL +
Sbjct: 604 N-ILERANQSIPEELVS 619


>gi|21071032 DEAD-box protein abstrakt [Homo sapiens]
          Length = 622

 Score =  290 bits (741), Expect = 5e-78
 Identities = 203/604 (33%), Positives = 311/604 (51%), Gaps = 60/604 (9%)

Query: 210 QERERRERRERMERETNGNEDEEGRQKIREEKDKSKELHAIKERYLGGIKKRRRTRHLND 269
           +E E   +R R +    G    E   +  E+      L   ++  L  + +RRR     +
Sbjct: 2   EESEPERKRARTDEVPAGGSRSEAEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGAAEE 61

Query: 270 RKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQKREQSRFYGDLMEKRRT 329
            +   +   SE    + +     +  V LL +     +  K + R++S     L E+ + 
Sbjct: 62  EQ---QDSGSEPRGDEDDIPLGPQSNVSLLDQH--QHLKEKAEARKESAKEKQLKEEEKI 116

Query: 330 LEEKEQEEARLRKLRKKEAKQRWDD---RHWSQKK--LDEMTDRDWRIFREDYSITTKGG 384
           LE   +  A L  +++      +DD     W+  +  L    +R  R+ R+ Y I  +G 
Sbjct: 117 LESVAEGRA-LMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERV-RKKYHILVEGD 174

Query: 385 KIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAA 444
            IP PI+S+K+   P  IL  + K G   PTPIQ Q IP  L  RD+IG+A TGSGKT  
Sbjct: 175 GIPPPIKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLV 234

Query: 445 FLIPLLVWITTLPKIDRIEESD-QGPYAIILAPTRELAQQ-----------IEEETIKFG 492
           F +P++++   L +  R+  S  +GPY +I+ P+RELA+Q           ++E++    
Sbjct: 235 FTLPVIMF--CLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDS---- 288

Query: 493 KPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEAD 552
            PL +R    IGG+S ++Q   +R G  +++ATPGRL+D+L+ + + L  C Y+ LDEAD
Sbjct: 289 SPL-LRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEAD 347

Query: 553 RMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPA 612
           RMIDMGFE D++ I  +                              RQT++F+ATMP  
Sbjct: 348 RMIDMGFEGDIRTIFSYF--------------------------KGQRQTLLFSATMPKK 381

Query: 613 VERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVN 672
           ++  A+S L +P  + +G AG     V Q+V  + E  K   LL  L Q   PP++IF  
Sbjct: 382 IQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECL-QKTPPPVLIFAE 440

Query: 673 QKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQD 732
           +K   D + + L   G  A  +HGGK QE+R  A+   + G KD+LVATDVA +G+D   
Sbjct: 441 KKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPA 500

Query: 733 VSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKE-DSAVFYELKQAILESPVSSC 791
           +  V+NYDM + IE+Y+HRIGRTGR+G +G+A TF+ K  D +V  +LK  +LE+     
Sbjct: 501 IQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAK-QKV 559

Query: 792 PPEL 795
           PP L
Sbjct: 560 PPVL 563


>gi|4758138 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 [Homo sapiens]
          Length = 614

 Score =  285 bits (730), Expect = 9e-77
 Identities = 163/455 (35%), Positives = 261/455 (57%), Gaps = 43/455 (9%)

Query: 345 KKEAKQRWD-------DRHWSQKKLD--EMTDRDWRIFREDYSITTKGGKIPNPIRSWKD 395
           +K  K++W+       ++++ Q+  D    T ++   +R    IT +G   P P+ ++ +
Sbjct: 39  EKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYE 98

Query: 396 SSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITT 455
           ++ P ++++VI +  + EPT IQ Q  P+ L   D++GVA+TGSGKT ++L+P +V I  
Sbjct: 99  ANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINH 158

Query: 456 LPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRL 515
            P ++R      GP  ++LAPTRELAQQ+++   ++ +   +++  + GG  +  Q   L
Sbjct: 159 QPFLER----GDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDL 214

Query: 516 RMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQ 575
             G EI IATPGRLID LE     L R TY+VLDEADRM+DMGFEP ++KI++ +     
Sbjct: 215 ERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQI----- 269

Query: 576 KPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAG-K 634
           +PD                     RQT+M++AT P  V +LA  +L+    + IG+    
Sbjct: 270 RPD---------------------RQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELS 308

Query: 635 PHERVEQKVFLMSESEKRKKLLAILEQGF---DPPIIIFVNQKKGCDVLAKSLEKMGYNA 691
            +  + Q V +  + EK +KL+ ++E+     +   I+FV  K+ CD L + + + G+ A
Sbjct: 309 ANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPA 368

Query: 692 CTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHR 751
             +HG K Q++R++ L+  K G   IL+ATDVA RG+D++DV  V+NYD   + EDYIHR
Sbjct: 369 MGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHR 428

Query: 752 IGRTGRAGKSGVAITFLTKEDSAVFYELKQAILES 786
           IGRT R+ K+G A TF T  +     +L   + E+
Sbjct: 429 IGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREA 463


>gi|87196351 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3 [Homo
           sapiens]
          Length = 662

 Score =  281 bits (719), Expect = 2e-75
 Identities = 168/443 (37%), Positives = 240/443 (54%), Gaps = 33/443 (7%)

Query: 375 EDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGV 434
           +D  +   G   P  I S+ D  +   I+  I+   Y  PTP+Q+ AIPI  + RD++  
Sbjct: 164 DDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMAC 223

Query: 435 AETGSGKTAAFLIPLLVWITT---------LPKIDRIEESDQGPYAIILAPTRELAQQIE 485
           A+TGSGKTAAFL+P+L  I +         + +  R     Q P +++LAPTRELA QI 
Sbjct: 224 AQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIY 283

Query: 486 EETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTY 545
           EE  KF     +R   V GG     Q   L  GC +++ATPGRL+D++E   + L  C Y
Sbjct: 284 EEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKY 343

Query: 546 VVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMF 605
           +VLDEADRM+DMGFEP +++I+E   +            P K +          R T+MF
Sbjct: 344 LVLDEADRMLDMGFEPQIRRIVEQDTM------------PPKGV----------RHTMMF 381

Query: 606 TATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQ-GFD 664
           +AT P  ++ LAR +L     + +G  G   E + QKV  + ES+KR  LL +L   G D
Sbjct: 382 SATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKD 441

Query: 665 PPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVA 724
              ++FV  KKG D L   L   GY   ++HG + Q  RE AL   ++G   ILVAT VA
Sbjct: 442 SLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVA 501

Query: 725 GRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAIL 784
            RG+DI +V  V+N+D+  +IE+Y+HRIGRTGR G  G+A +F  + +  +  +L   ++
Sbjct: 502 ARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLV 561

Query: 785 ESPVSSCPPELANHPDAQHKPGT 807
           E+     P  L N     H  G+
Sbjct: 562 EAK-QEVPSWLENMAYEHHYKGS 583


>gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens]
          Length = 938

 Score =  277 bits (709), Expect = 2e-74
 Identities = 162/416 (38%), Positives = 234/416 (56%), Gaps = 32/416 (7%)

Query: 360 KKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQR 419
           +++  +T +     R   ++   G   P P  S+        ++  I K  Y +PTPIQ 
Sbjct: 222 EEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQC 281

Query: 420 QAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRE 479
           Q +P+ L  RD+IG+A+TGSGKTAAF+ P+L+ I    ++    E   GP A+I+ PTRE
Sbjct: 282 QGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKEL----EPGDGPIAVIVCPTRE 337

Query: 480 LAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLV 539
           L QQI  E  +FGK   +R+VAV GG S  +Q   L+ G EIV+ TPGRLID ++ +   
Sbjct: 338 LCQQIHAECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATN 397

Query: 540 LSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKY 599
           L R +Y+V DEADRM DMGFE  V+ I  H+     +PD                     
Sbjct: 398 LQRVSYLVFDEADRMFDMGFEYQVRSIASHV-----RPD--------------------- 431

Query: 600 RQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLA-- 657
           RQT++F+AT    +E+LAR  L  P  V  G  G+ +E V Q V ++     +   L   
Sbjct: 432 RQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRR 491

Query: 658 ILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDI 717
           ++E      +++FV +K   + LA +L++ G+N   LHG   Q +R   +S+ K     +
Sbjct: 492 LVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPV 551

Query: 718 LVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDS 773
           LVATDVA RG+DI  +  V+NYD+A++I+ + HRIGRTGRAG+ GVA T LT +DS
Sbjct: 552 LVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDS 607



 Score = 36.6 bits (83), Expect = 0.097
 Identities = 23/110 (20%), Positives = 48/110 (43%), Gaps = 2/110 (1%)

Query: 33  DRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAERERRHKERERDKERDRNKKDRDR 92
           +  R+ +   + KR R  + R     S   + ++ ++  R H +  R  +  R+ +   R
Sbjct: 794 NNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPR-HGDGGRHGDGYRHPESSSR 852

Query: 93  DKDGHRRDKDRKRSSLS-PGRGKDFKSRKDRDSKKDEEDEHGDKKPKAQP 141
             DGHR  ++R   S    G  +     ++ +S+K+  +     +PK +P
Sbjct: 853 HTDGHRHGENRHGGSAGRHGENRGANDGRNGESRKEAFNRESKMEPKMEP 902


>gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens]
          Length = 938

 Score =  277 bits (709), Expect = 2e-74
 Identities = 162/416 (38%), Positives = 234/416 (56%), Gaps = 32/416 (7%)

Query: 360 KKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQR 419
           +++  +T +     R   ++   G   P P  S+        ++  I K  Y +PTPIQ 
Sbjct: 222 EEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQC 281

Query: 420 QAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRE 479
           Q +P+ L  RD+IG+A+TGSGKTAAF+ P+L+ I    ++    E   GP A+I+ PTRE
Sbjct: 282 QGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKEL----EPGDGPIAVIVCPTRE 337

Query: 480 LAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLV 539
           L QQI  E  +FGK   +R+VAV GG S  +Q   L+ G EIV+ TPGRLID ++ +   
Sbjct: 338 LCQQIHAECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATN 397

Query: 540 LSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKY 599
           L R +Y+V DEADRM DMGFE  V+ I  H+     +PD                     
Sbjct: 398 LQRVSYLVFDEADRMFDMGFEYQVRSIASHV-----RPD--------------------- 431

Query: 600 RQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLA-- 657
           RQT++F+AT    +E+LAR  L  P  V  G  G+ +E V Q V ++     +   L   
Sbjct: 432 RQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRR 491

Query: 658 ILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDI 717
           ++E      +++FV +K   + LA +L++ G+N   LHG   Q +R   +S+ K     +
Sbjct: 492 LVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPV 551

Query: 718 LVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDS 773
           LVATDVA RG+DI  +  V+NYD+A++I+ + HRIGRTGRAG+ GVA T LT +DS
Sbjct: 552 LVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDS 607



 Score = 36.6 bits (83), Expect = 0.097
 Identities = 23/110 (20%), Positives = 48/110 (43%), Gaps = 2/110 (1%)

Query: 33  DRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAERERRHKERERDKERDRNKKDRDR 92
           +  R+ +   + KR R  + R     S   + ++ ++  R H +  R  +  R+ +   R
Sbjct: 794 NNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPR-HGDGGRHGDGYRHPESSSR 852

Query: 93  DKDGHRRDKDRKRSSLS-PGRGKDFKSRKDRDSKKDEEDEHGDKKPKAQP 141
             DGHR  ++R   S    G  +     ++ +S+K+  +     +PK +P
Sbjct: 853 HTDGHRHGENRHGGSAGRHGENRGANDGRNGESRKEAFNRESKMEPKMEP 902


>gi|169881239 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
           [Homo sapiens]
          Length = 660

 Score =  277 bits (708), Expect = 3e-74
 Identities = 167/442 (37%), Positives = 238/442 (53%), Gaps = 33/442 (7%)

Query: 375 EDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGV 434
           +D  +   G   P  I ++ D  +   I+  I+   Y  PTP+Q+ AIPI    RD++  
Sbjct: 162 DDIPVEATGSNCPPHIENFSDIDMGEIIMGNIELTRYTRPTPVQKHAIPIIKGKRDLMAC 221

Query: 435 AETGSGKTAAFLIPLLVWITT---------LPKIDRIEESDQGPYAIILAPTRELAQQIE 485
           A+TGSGKTAAFL+P+L  I T         + +  R     Q P +++LAPTRELA QI 
Sbjct: 222 AQTGSGKTAAFLLPILSQIYTDGPGEALKAVKENGRYGRRKQYPISLVLAPTRELAVQIY 281

Query: 486 EETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTY 545
           EE  KF     +R   V GG     Q   L  GC +++ATPGRL+D++E   + L  C Y
Sbjct: 282 EEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKY 341

Query: 546 VVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMF 605
           +VLDEADRM+DMGFEP +++I+E   +            P K +          R T+MF
Sbjct: 342 LVLDEADRMLDMGFEPQIRRIVEQDTM------------PPKGV----------RHTMMF 379

Query: 606 TATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAIL-EQGFD 664
           +AT P  ++ LAR +L     + +G  G   E + QKV  + + +KR  LL IL   G D
Sbjct: 380 SATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEDLDKRSFLLDILGATGSD 439

Query: 665 PPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVA 724
              ++FV  KKG D L   L   GY   ++HG + Q  RE AL   ++G   ILVAT VA
Sbjct: 440 SLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVA 499

Query: 725 GRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAIL 784
            RG+DI +V  V+N+D+  +IE+Y+HRIGRTGR G  G+A +F  +++  +  +L   ++
Sbjct: 500 ARGLDISNVRHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNEKNMNITKDLLDLLV 559

Query: 785 ESPVSSCPPELANHPDAQHKPG 806
           E+     P  L N     H  G
Sbjct: 560 EAK-QEVPSWLENMAYEHHYKG 580


>gi|13514809 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
           [Homo sapiens]
          Length = 660

 Score =  277 bits (708), Expect = 3e-74
 Identities = 167/442 (37%), Positives = 238/442 (53%), Gaps = 33/442 (7%)

Query: 375 EDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGV 434
           +D  +   G   P  I ++ D  +   I+  I+   Y  PTP+Q+ AIPI    RD++  
Sbjct: 162 DDIPVEATGSNCPPHIENFSDIDMGEIIMGNIELTRYTRPTPVQKHAIPIIKGKRDLMAC 221

Query: 435 AETGSGKTAAFLIPLLVWITT---------LPKIDRIEESDQGPYAIILAPTRELAQQIE 485
           A+TGSGKTAAFL+P+L  I T         + +  R     Q P +++LAPTRELA QI 
Sbjct: 222 AQTGSGKTAAFLLPILSQIYTDGPGEALKAVKENGRYGRRKQYPISLVLAPTRELAVQIY 281

Query: 486 EETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTY 545
           EE  KF     +R   V GG     Q   L  GC +++ATPGRL+D++E   + L  C Y
Sbjct: 282 EEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKY 341

Query: 546 VVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMF 605
           +VLDEADRM+DMGFEP +++I+E   +            P K +          R T+MF
Sbjct: 342 LVLDEADRMLDMGFEPQIRRIVEQDTM------------PPKGV----------RHTMMF 379

Query: 606 TATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAIL-EQGFD 664
           +AT P  ++ LAR +L     + +G  G   E + QKV  + + +KR  LL IL   G D
Sbjct: 380 SATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEDLDKRSFLLDILGATGSD 439

Query: 665 PPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVA 724
              ++FV  KKG D L   L   GY   ++HG + Q  RE AL   ++G   ILVAT VA
Sbjct: 440 SLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVA 499

Query: 725 GRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAIL 784
            RG+DI +V  V+N+D+  +IE+Y+HRIGRTGR G  G+A +F  +++  +  +L   ++
Sbjct: 500 ARGLDISNVRHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNEKNMNITKDLLDLLV 559

Query: 785 ESPVSSCPPELANHPDAQHKPG 806
           E+     P  L N     H  G
Sbjct: 560 EAK-QEVPSWLENMAYEHHYKG 580


>gi|188035877 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 [Homo
           sapiens]
          Length = 619

 Score =  266 bits (681), Expect = 4e-71
 Identities = 153/431 (35%), Positives = 249/431 (57%), Gaps = 42/431 (9%)

Query: 374 REDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIG 433
           ++   I  +G ++  PI  ++  SLP  +   + K GY+ PTPIQ Q IP+GL  RDI+ 
Sbjct: 186 KQQLGILVQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILA 245

Query: 434 VAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEET--IKF 491
            A+TGSGKTAAFL+P+++         R     + P A+IL PTRELA QIE +   +  
Sbjct: 246 SADTGSGKTAAFLLPVIM---------RALFESKTPSALILTPTRELAIQIERQAKELMS 296

Query: 492 GKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEA 551
           G P  ++TV ++GG+    Q +RL+   +++IATPGRL+D+++   + L     VV+DEA
Sbjct: 297 GLP-RMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEA 355

Query: 552 DRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPP 611
           D M+ MGF+  V  ILE++P                             QT++ +AT+P 
Sbjct: 356 DTMLKMGFQQQVLDILENIP--------------------------NDCQTILVSATIPT 389

Query: 612 AVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAIL--EQGFDPPIII 669
           ++E+LA   L  P  +  G    P   V Q +  + +  K+KKL  IL  ++ F PP+++
Sbjct: 390 SIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVEDPAKKKKLFEILNDKKLFKPPVLV 449

Query: 670 FVNQKKGCDVLAKSLEKM-GYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGI 728
           FV+ K G D+L+++++K+ G  + ++H  K Q +R+  L  L  G  +++V+T V GRG+
Sbjct: 450 FVDCKLGADLLSEAVQKITGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGL 509

Query: 729 DIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAILESPV 788
           D+  V +VVN+DM  ++++Y+H+IGR GR G++G AITF+      +F+++ + + +   
Sbjct: 510 DLISVRLVVNFDMPSSMDEYVHQIGRVGRLGQNGTAITFINNNSKRLFWDIAKRV-KPTG 568

Query: 789 SSCPPELANHP 799
           S  PP+L N P
Sbjct: 569 SILPPQLLNSP 579


>gi|55749865 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 [Homo
           sapiens]
          Length = 631

 Score =  260 bits (665), Expect = 3e-69
 Identities = 174/465 (37%), Positives = 263/465 (56%), Gaps = 46/465 (9%)

Query: 362 LDEMTDRDWRIFREDYSITT---KGGK---IPNPIRSWKDSSLP-PHILEVIDKCGYKEP 414
           + EM   +WR  +E+++IT    K G+   IP P   +KD+    P +L+ I + G  +P
Sbjct: 188 MSEMQVINWR--KENFNITCDDLKSGEKRLIPKPTCRFKDAFQQYPDLLKSIIRVGIVKP 245

Query: 415 TPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIIL 474
           TPIQ QA PI LQ  D+I VA+TG+GKT ++L+P  + + + P I R  E   GP  ++L
Sbjct: 246 TPIQSQAWPIILQGIDLIVVAQTGTGKTLSYLMPGFIHLDSQP-ISR--EQRNGPGMLVL 302

Query: 475 APTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLE 534
            PTRELA  +E E  K+    G++++ + GG +R  Q   +  G +I+IATPGRL D+  
Sbjct: 303 TPTRELALHVEAECSKYSYK-GLKSICIYGGRNRNGQIEDISKGVDIIIATPGRLNDLQM 361

Query: 535 NRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFES 594
           N  + L   TY+V+DEAD+M+DM FEP ++KIL  +     +PD                
Sbjct: 362 NNSVNLRSITYLVIDEADKMLDMEFEPQIRKILLDV-----RPD---------------- 400

Query: 595 GKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPH-ERVEQKVFLMSESEKRK 653
                RQTVM +AT P  V +LA SYL+ P +VY+G+        V+Q + + +E EKR 
Sbjct: 401 -----RQTVMTSATWPDTVRQLALSYLKDPMIVYVGNLNLVAVNTVKQNIIVTTEKEKRA 455

Query: 654 KLLAILEQ-GFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKA 712
                +E    +  +I+FV+QK   D L+      G +A +LHG   Q  +E A+ + K+
Sbjct: 456 LTQEFVENMSPNDKVIMFVSQKHIADDLSSDFNIQGISAESLHGNSEQSDQERAVEDFKS 515

Query: 713 GAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKED 772
           G   IL+ TD+  RG+D+ DV+ V NYD  +NI+ Y+HR+G  GR GK+G ++T +T+ D
Sbjct: 516 GNIKILITTDIVSRGLDLNDVTHVYNYDFPRNIDVYVHRVGYIGRTGKTGTSVTLITQRD 575

Query: 773 SAVFYELKQAILESPVSSCPPELANHPDAQHKPGTILTKKRREET 817
           S +  EL + IL+    S P +L    + Q+K   +  +KR  ET
Sbjct: 576 SKMAGELIK-ILDRANQSVPEDLVVMAE-QYK---LNQQKRHRET 615


>gi|20149629 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 isoform 1
           [Homo sapiens]
          Length = 455

 Score =  253 bits (647), Expect = 4e-67
 Identities = 150/394 (38%), Positives = 224/394 (56%), Gaps = 36/394 (9%)

Query: 391 RSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLL 450
           +++KD  +   + E  D+ G+ +PT IQ +AIP+ LQ RDIIG+AETGSGKT AF +P+L
Sbjct: 24  KTFKDLGVTDVLCEACDQLGWTKPTKIQIEAIPLALQGRDIIGLAETGSGKTGAFALPIL 83

Query: 451 VWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISRED 510
                    + + E+ Q  +A++L PTRELA QI E+    G  +G+++  ++GGI    
Sbjct: 84  ---------NALLETPQRLFALVLTPTRELAFQISEQFEALGSSIGVQSAVIVGGIDSMS 134

Query: 511 QGFRLRMGCEIVIATPGRLIDVLEN-RYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEH 569
           Q   L     I+IATPGRLID LEN +   L    Y+V+DEADR+++M FE +V KIL+ 
Sbjct: 135 QSLALAKKPHIIIATPGRLIDHLENTKGFNLRALKYLVMDEADRILNMDFETEVDKILKV 194

Query: 570 MPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYI 629
           +P                          + R+T +F+ATM   V++L R+ L+ P    +
Sbjct: 195 IP--------------------------RDRKTFLFSATMTKKVQKLQRAALKNPVKCAV 228

Query: 630 GSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGY 689
            S  +  E+++Q    +    K   L+ IL +      +IF +        A  L  +G+
Sbjct: 229 SSKYQTVEKLQQYYIFIPSKFKDTYLVYILNELAGNSFMIFCSTCNNTQRTALLLRNLGF 288

Query: 690 NACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYI 749
            A  LHG   Q +R  +L+  KA A+ IL+ATDVA RG+DI  V +VVN+D+  + +DYI
Sbjct: 289 TAIPLHGQMSQSKRLGSLNKFKAKARSILLATDVASRGLDIPHVDVVVNFDIPTHSKDYI 348

Query: 750 HRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAI 783
           HR+GRT RAG+SG AITF+T+ D  +F  ++  I
Sbjct: 349 HRVGRTARAGRSGKAITFVTQYDVELFQRIEHLI 382


>gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3
           [Homo sapiens]
          Length = 724

 Score =  250 bits (638), Expect = 4e-66
 Identities = 149/400 (37%), Positives = 224/400 (56%), Gaps = 35/400 (8%)

Query: 379 ITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETG 438
           +   G   P  I ++++++L   +   I K GY + TP+Q+ +IPI L  RD++  A+TG
Sbjct: 276 VEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIILAGRDLMACAQTG 335

Query: 439 SGKTAAFLIPLLVWIT----TLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKP 494
           SGKTAAFL+P+L  +     T  +   ++E    P  II+APTREL  QI  E  KF   
Sbjct: 336 SGKTAAFLLPILAHMMHDGITASRFKELQE----PECIIVAPTRELVNQIYLEARKFSFG 391

Query: 495 LGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRM 554
             +R V + GG        ++  GC I+ ATPGRL+D++    + L +  Y+VLDEADRM
Sbjct: 392 TCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGKEKIGLKQIKYLVLDEADRM 451

Query: 555 IDMGFEPDVQKILE--HMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPA 612
           +DMGF P+++K++    MP   Q                        RQT+MF+AT P  
Sbjct: 452 LDMGFGPEMKKLISCPGMPSKEQ------------------------RQTLMFSATFPEE 487

Query: 613 VERLARSYLRRPAV-VYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFV 671
           ++RLA  +L+   + V +G  G     V+Q V  + +  KR+KL+ IL    D   ++FV
Sbjct: 488 IQRLAAEFLKSNYLFVAVGQVGGACRDVQQTVLQVGQFSKREKLVEILRNIGDERTMVFV 547

Query: 672 NQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQ 731
             KK  D +A  L +   +  ++HG + Q +RE AL + + G   +LVAT VA RG+DI+
Sbjct: 548 ETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKCPVLVATSVAARGLDIE 607

Query: 732 DVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKE 771
           +V  V+N+D+   I++Y+HRIGRTGR G +G AI+F   E
Sbjct: 608 NVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLE 647


>gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1
           [Homo sapiens]
          Length = 724

 Score =  250 bits (638), Expect = 4e-66
 Identities = 149/400 (37%), Positives = 224/400 (56%), Gaps = 35/400 (8%)

Query: 379 ITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETG 438
           +   G   P  I ++++++L   +   I K GY + TP+Q+ +IPI L  RD++  A+TG
Sbjct: 276 VEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIILAGRDLMACAQTG 335

Query: 439 SGKTAAFLIPLLVWIT----TLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKP 494
           SGKTAAFL+P+L  +     T  +   ++E    P  II+APTREL  QI  E  KF   
Sbjct: 336 SGKTAAFLLPILAHMMHDGITASRFKELQE----PECIIVAPTRELVNQIYLEARKFSFG 391

Query: 495 LGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRM 554
             +R V + GG        ++  GC I+ ATPGRL+D++    + L +  Y+VLDEADRM
Sbjct: 392 TCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGKEKIGLKQIKYLVLDEADRM 451

Query: 555 IDMGFEPDVQKILE--HMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPA 612
           +DMGF P+++K++    MP   Q                        RQT+MF+AT P  
Sbjct: 452 LDMGFGPEMKKLISCPGMPSKEQ------------------------RQTLMFSATFPEE 487

Query: 613 VERLARSYLRRPAV-VYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFV 671
           ++RLA  +L+   + V +G  G     V+Q V  + +  KR+KL+ IL    D   ++FV
Sbjct: 488 IQRLAAEFLKSNYLFVAVGQVGGACRDVQQTVLQVGQFSKREKLVEILRNIGDERTMVFV 547

Query: 672 NQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQ 731
             KK  D +A  L +   +  ++HG + Q +RE AL + + G   +LVAT VA RG+DI+
Sbjct: 548 ETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKCPVLVATSVAARGLDIE 607

Query: 732 DVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKE 771
           +V  V+N+D+   I++Y+HRIGRTGR G +G AI+F   E
Sbjct: 608 NVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLE 647


>gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2
           [Homo sapiens]
          Length = 690

 Score =  250 bits (638), Expect = 4e-66
 Identities = 149/400 (37%), Positives = 224/400 (56%), Gaps = 35/400 (8%)

Query: 379 ITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETG 438
           +   G   P  I ++++++L   +   I K GY + TP+Q+ +IPI L  RD++  A+TG
Sbjct: 242 VEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIILAGRDLMACAQTG 301

Query: 439 SGKTAAFLIPLLVWIT----TLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKP 494
           SGKTAAFL+P+L  +     T  +   ++E    P  II+APTREL  QI  E  KF   
Sbjct: 302 SGKTAAFLLPILAHMMHDGITASRFKELQE----PECIIVAPTRELVNQIYLEARKFSFG 357

Query: 495 LGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRM 554
             +R V + GG        ++  GC I+ ATPGRL+D++    + L +  Y+VLDEADRM
Sbjct: 358 TCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGKEKIGLKQIKYLVLDEADRM 417

Query: 555 IDMGFEPDVQKILE--HMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPA 612
           +DMGF P+++K++    MP   Q                        RQT+MF+AT P  
Sbjct: 418 LDMGFGPEMKKLISCPGMPSKEQ------------------------RQTLMFSATFPEE 453

Query: 613 VERLARSYLRRPAV-VYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFV 671
           ++RLA  +L+   + V +G  G     V+Q V  + +  KR+KL+ IL    D   ++FV
Sbjct: 454 IQRLAAEFLKSNYLFVAVGQVGGACRDVQQTVLQVGQFSKREKLVEILRNIGDERTMVFV 513

Query: 672 NQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQ 731
             KK  D +A  L +   +  ++HG + Q +RE AL + + G   +LVAT VA RG+DI+
Sbjct: 514 ETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKCPVLVATSVAARGLDIE 573

Query: 732 DVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKE 771
           +V  V+N+D+   I++Y+HRIGRTGR G +G AI+F   E
Sbjct: 574 NVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLE 613


>gi|41327776 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 isoform 2
           [Homo sapiens]
          Length = 406

 Score =  219 bits (557), Expect = 1e-56
 Identities = 138/394 (35%), Positives = 206/394 (52%), Gaps = 85/394 (21%)

Query: 391 RSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLL 450
           +++KD  +   + E  D+ G+ +PT IQ +AIP+ LQ RDIIG+AETGSGKT AF +P+L
Sbjct: 24  KTFKDLGVTDVLCEACDQLGWTKPTKIQIEAIPLALQGRDIIGLAETGSGKTGAFALPIL 83

Query: 451 VWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISRED 510
                    + + E+ Q  +A++L PTRELA QI E+    G  +G+++  ++GGI    
Sbjct: 84  ---------NALLETPQRLFALVLTPTRELAFQISEQFEALGSSIGVQSAVIVGGIDSMS 134

Query: 511 QGFRLRMGCEIVIATPGRLIDVLEN-RYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEH 569
           Q   L     I+IATPGRLID LEN +   L    Y+V+DEADR+++M FE +V KIL+ 
Sbjct: 135 QSLALAKKPHIIIATPGRLIDHLENTKGFNLRALKYLVMDEADRILNMDFETEVDKILKV 194

Query: 570 MPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYI 629
           +P                          + R+T +F+ATM   V++L R+ L+ P    +
Sbjct: 195 IP--------------------------RDRKTFLFSATMTKKVQKLQRAALKNPVKCAV 228

Query: 630 GSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGY 689
            S  +  E+++Q    +    K K+L                                  
Sbjct: 229 SSKYQTVEKLQQYYIFIPSKFKSKRL---------------------------------- 254

Query: 690 NACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYI 749
                           +L+  KA A+ IL+ATDVA RG+DI  V +VVN+D+  + +DYI
Sbjct: 255 ---------------GSLNKFKAKARSILLATDVASRGLDIPHVDVVVNFDIPTHSKDYI 299

Query: 750 HRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAI 783
           HR+GRT RAG+SG AITF+T+ D  +F  ++  I
Sbjct: 300 HRVGRTARAGRSGKAITFVTQYDVELFQRIEHLI 333


>gi|224593278 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 [Homo
           sapiens]
          Length = 796

 Score =  217 bits (552), Expect = 4e-56
 Identities = 166/549 (30%), Positives = 269/549 (48%), Gaps = 74/549 (13%)

Query: 280 EDTSIDYNP--LYKERHQVQLLGRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEE 337
           ++ S D+NP  ++ E+      G   +A +  + +K+  +    + +EK R   + E +E
Sbjct: 76  KNRSADFNPDFVFTEKEGTYD-GSWALADVMSQLKKKRAATTLDEKIEKVRKKRKTEDKE 134

Query: 338 ARLRKLRK-KEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYS-----ITTKGGKIPNPIR 391
           A+  KL K KEAK+  + +     + ++    +      DYS     I TK   +    R
Sbjct: 135 AKSGKLEKEKEAKEGSEPKEQEDLQENDEEGSEDEASETDYSSADENILTKADTLKVKDR 194

Query: 392 ------------------------SWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQ 427
                                   S++D +L   +L+ I   G+K+PTPIQ+  IP+GL 
Sbjct: 195 KKKKKKGQEAGGFFEDASQYDENLSFQDMNLSRPLLKAITAMGFKQPTPIQKACIPVGLL 254

Query: 428 NRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPY--AIILAPTRELAQQIE 485
            +DI   A TG+GKTAAF +P+L  +   P+        Q P    ++L PTREL  Q+ 
Sbjct: 255 GKDICACAATGTGKTAAFALPVLERLIYKPR--------QAPVTRVLVLVPTRELGIQVH 306

Query: 486 EETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLEN-RYLVLSRCT 544
             T +  +   I T   +GG+  + Q   LR   +I+IATPGRLID L N     LS   
Sbjct: 307 SVTRQLAQFCNITTCLAVGGLDVKSQEAALRAAPDILIATPGRLIDHLHNCPSFHLSSIE 366

Query: 545 YVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVM 604
            ++LDEADRM+D  FE  +++I+                   +M ++       +RQT++
Sbjct: 367 VLILDEADRMLDEYFEEQMKEII-------------------RMCSH-------HRQTML 400

Query: 605 FTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLM---SESEKRKKLLAILEQ 661
           F+ATM   V+ LA   L+ P  +++ S       + Q+   +    E ++   + A+L +
Sbjct: 401 FSATMTDEVKDLASVSLKNPVRIFVNSNTDVAPFLRQEFIRIRPNREGDREAIVAALLTR 460

Query: 662 GFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVAT 721
            F   +++F   KK    +   L  MG     LHG   Q QR  AL   K    DILVAT
Sbjct: 461 TFTDHVMLFTQTKKQAHRMHILLGLMGLQVGELHGNLSQTQRLEALRRFKDEQIDILVAT 520

Query: 722 DVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQ 781
           DVA RG+DI+ V  V+N+ M   I+ Y+HR+GRT RAG++G +++ + +++  +  E+ +
Sbjct: 521 DVAARGLDIEGVKTVINFTMPNTIKHYVHRVGRTARAGRAGRSVSLVGEDERKMLKEIVK 580

Query: 782 AILESPVSS 790
           A  ++PV +
Sbjct: 581 A-AKAPVKA 588



 Score = 36.6 bits (83), Expect = 0.097
 Identities = 37/157 (23%), Positives = 75/157 (47%), Gaps = 21/157 (13%)

Query: 128 EEDEHGDKKPKAQPLSLEELLAK-KKAEEEAEAKPKFLSKAEREAEALKRRQQEVE---- 182
           E +E   ++ +AQ  + + LL K K+A  +   +  F +K ER+ E + +  QE +    
Sbjct: 617 EAEEKEMQQSEAQINTAKRLLEKGKEAVVQEPERSWFQTKEERKKEKIAKALQEFDLALR 676

Query: 183 ---ERQRMLEEERKK-------RKQFQDLGRKML-EDPQERERRERRERMERETN----- 226
              +R++ +++ +KK       R QF+ L  +M  E   +R RR +R R   E       
Sbjct: 677 GKKKRKKFMKDAKKKGEMTAEERSQFEILKAQMFAERLAKRNRRAKRARAMPEEEPVRGP 736

Query: 227 GNEDEEGRQKIREEKDKSKELHAIKERYLGGIKKRRR 263
             + ++G++ + +E+  +    A+K+   G   + R+
Sbjct: 737 AKKQKQGKKSVFDEELTNTSKKALKQYRAGPSFEERK 773



 Score = 33.9 bits (76), Expect = 0.63
 Identities = 40/186 (21%), Positives = 78/186 (41%), Gaps = 14/186 (7%)

Query: 120 KDRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFL----------SKAER 169
           +D +   + E + GD++ +  P+ L            A+  P F+          S A  
Sbjct: 44  EDDEVPVEPESDSGDEEEEG-PIVLGRRQKALGKNRSADFNPDFVFTEKEGTYDGSWALA 102

Query: 170 EAEALKRRQQEVEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNE 229
           +  +  ++++        +E+ RKKRK  +D   K  +  +E+E +E  E  E+E     
Sbjct: 103 DVMSQLKKKRAATTLDEKIEKVRKKRKT-EDKEAKSGKLEKEKEAKEGSEPKEQEDLQEN 161

Query: 230 DEEGRQKIREEKD-KSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASE-DTSIDYN 287
           DEEG +    E D  S + + + +     +K R++ +        F  DAS+ D ++ + 
Sbjct: 162 DEEGSEDEASETDYSSADENILTKADTLKVKDRKKKKKKGQEAGGFFEDASQYDENLSFQ 221

Query: 288 PLYKER 293
            +   R
Sbjct: 222 DMNLSR 227


>gi|31542656 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 [Homo
           sapiens]
          Length = 483

 Score =  210 bits (535), Expect = 4e-54
 Identities = 131/390 (33%), Positives = 205/390 (52%), Gaps = 43/390 (11%)

Query: 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDR 461
           ++E   + G K+PTP+Q   IP  L+ RD +G A+TGSGKTAAF++P+L          +
Sbjct: 13  LVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPIL---------QK 63

Query: 462 IEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEI 521
           + E   G + ++L PTRELA QI E+    GKPLG++   ++GG+    Q   L     +
Sbjct: 64  LSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHV 123

Query: 522 VIATPGRLIDVLEN-RYLVLSRCTYVVLDEADRMIDMG---FEPDVQKILEHMPVSNQKP 577
           VIATPGRL D L +     + +  ++V+DEADR+++ G   F  D++ IL  +P      
Sbjct: 124 VIATPGRLADHLRSSNTFSIKKIRFLVMDEADRLLEQGCTDFTVDLEAILAAVPAR---- 179

Query: 578 DTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHE 637
                                 RQT++F+AT+   +  L      +P      +     E
Sbjct: 180 ----------------------RQTLLFSATLTDTLRELQGLATNQPFFWEAQAPVSTVE 217

Query: 638 RVEQKVFLMSESEKRKKLLAILEQGFDP----PIIIFVNQKKGCDVLAKSLEKMGYNACT 693
           +++Q+  L+ E  K   L+ ++++  D      IIIF N  K C +L   L K  +    
Sbjct: 218 QLDQRYLLVPEKVKDAYLVHLIQRFQDEHEDWSIIIFTNTCKTCQILCMMLRKFSFPTVA 277

Query: 694 LHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIG 753
           LH    Q++R  AL+  K+    IL+ATDVA RG+DI  V +V+N++     + YIHR+G
Sbjct: 278 LHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVG 337

Query: 754 RTGRAGKSGVAITFLTKEDSAVFYELKQAI 783
           RT RAG+ G AIT +T+ D  + + +++ I
Sbjct: 338 RTARAGRQGQAITLVTQYDIHLVHAIEEQI 367


>gi|38569505 ATP-dependent RNA helicase ROK1 isoform a [Homo
           sapiens]
          Length = 599

 Score =  208 bits (529), Expect = 2e-53
 Identities = 152/504 (30%), Positives = 257/504 (50%), Gaps = 64/504 (12%)

Query: 309 LKQQKREQSRFYGDLMEKRRTLEEK---EQEEARLRKLRKKEAK------QRWDDRHWSQ 359
           L ++KREQS+      +KR+T+  +   ++E A ++ +   EAK      QR  +   + 
Sbjct: 78  LTERKREQSK------KKRKTMTSEIASQEEGATIQWMSSVEAKIEDKKVQR--ESKLTS 129

Query: 360 KKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWK----DSSLPPHILEVIDKCGYKEPT 415
            KL+ +        R  + I  +G  +P+PI +++    +  +   +L+ I   G++ PT
Sbjct: 130 GKLENLRKEKINFLRNKHKIHVQGTDLPDPIATFQQLDQEYKINSRLLQNILDAGFQMPT 189

Query: 416 PIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILA 475
           PIQ QAIP+ L  R+++  A TGSGKT AF IP+L+ +         + +++G  A+I++
Sbjct: 190 PIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLK--------QPANKGFRALIIS 241

Query: 476 PTRELAQQIEEETIKFGKPLGIRTVAVI-GGISREDQGFRLRMGCEIVIATPGRLIDVLE 534
           PTRELA QI  E IK  +  G R   +    ++ +  G +     +I++ TP RLI +L+
Sbjct: 242 PTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLK 301

Query: 535 NRY--LVLSRCTYVVLDEADRMID---MGFEPDVQKILEHMPVSNQKPDTDEAEDPEKML 589
                + L+   ++V+DE+D++ +    GF   +  I                       
Sbjct: 302 QDPPGIDLASVEWLVVDESDKLFEDGKTGFRDQLASIF---------------------- 339

Query: 590 ANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKV-FLMSE 648
                  HK R+  MF+AT    VE+  +  L     V IG+     E VEQ++ F+ SE
Sbjct: 340 --LACTSHKVRRA-MFSATFAYDVEQWCKLNLDNVISVSIGARNSAVETVEQELLFVGSE 396

Query: 649 SEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALS 708
           + K   +  ++++GF+PP+++FV   +    L   L   G N   +H  + Q+QR+  + 
Sbjct: 397 TGKLLAMRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVH 456

Query: 709 NLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFL 768
           + +AG   +L+ T +  RGID + V++V+NYD   +  +YIHRIGRTGRAG  G AITF 
Sbjct: 457 SFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFF 516

Query: 769 TKEDSAVFYELKQAILESPVSSCP 792
           T++D  +   +   I +   + CP
Sbjct: 517 TEDDKPLLRSVANVIQQ---AGCP 537


>gi|51094101 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 2
           [Homo sapiens]
          Length = 881

 Score =  206 bits (523), Expect = 9e-53
 Identities = 127/380 (33%), Positives = 194/380 (51%), Gaps = 35/380 (9%)

Query: 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDR 461
           + + I K GYK PTPIQR+ IP+ L  +D++ +A TGSGKTA FL+P+   + T      
Sbjct: 107 VFKGIMKKGYKVPTPIQRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERLKT------ 160

Query: 462 IEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEI 521
              +  G  A+IL+PTRELA Q  + T + GK  G++T  ++GG   EDQ   L    +I
Sbjct: 161 -HSAQTGARALILSPTRELALQTLKFTKELGKFTGLKTALILGGDRMEDQFAALHENPDI 219

Query: 522 VIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDE 581
           +IATPGRL+ V     L L    YVV DEADR+ +MGF   +Q+I+  +P          
Sbjct: 220 IIATPGRLVHVAVEMSLKLQSVEYVVFDEADRLFEMGFAEQLQEIIARLP---------- 269

Query: 582 AEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQ 641
                        G H   QTV+F+AT+P  +   AR+ L  P ++ +    K +E+++ 
Sbjct: 270 -------------GGH---QTVLFSATLPKLLVEFARAGLTEPVLIRLDVDTKLNEQLKT 313

Query: 642 KVFLMSESEKRKKLLAILEQGFDP--PIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKG 699
             FL+ E  K   LL +L     P    ++FV  K   + L + L     +   ++    
Sbjct: 314 SFFLVREDTKAAVLLHLLHNVVRPQDQTVVFVATKHHAEYLTELLTTQRVSCAHIYSALD 373

Query: 700 QEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAG 759
              R+  L+    G    L+ TD+A RG+DI  +  V+NY      + ++HR+GR  RAG
Sbjct: 374 PTARKINLAKFTLGKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAG 433

Query: 760 KSGVAITFLTKEDSAVFYEL 779
           +SG A + +  ++     +L
Sbjct: 434 RSGTAYSLVAPDEIPYLLDL 453



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 54/285 (18%), Positives = 108/285 (37%), Gaps = 33/285 (11%)

Query: 8   KKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGS---------- 57
           +KDR A    ++ ++ R   +E        S P+   K+    +    G           
Sbjct: 595 QKDRKAIARFQQGQQGRQEQQEGPVG-PAPSRPALQEKQPEKEEEEEAGESVEDIFSEVV 653

Query: 58  -RSRSRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDF 116
            R R RS      + RR + R+RD+E     + +D D +         R     G G  F
Sbjct: 654 GRKRQRSGPNRGAKRRREEARQRDQEFYIPYRPKDFDSE---------RGLSISGEGGAF 704

Query: 117 KSRKDRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKR 176
           + +          DE  +     Q L  +    +   +   E K K  +++ R   +  +
Sbjct: 705 EQQAAGAVLDLMGDEAQNLTRGRQQLKWDRKKKRFVGQSGQEDKKKIKTESGRYISSSYK 764

Query: 177 RQ--QEVEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEE-- 232
           R   Q+ +++Q++ + +  +       G +     ++R +   R        G    E  
Sbjct: 765 RDLYQKWKQKQKIDDRDSDEEGASDRRGPERRGGKRDRGQGASRPHAPGTPAGRVRPELK 824

Query: 233 GRQKIREEKDKSKELHAIKERYLGGIKK-----RRRTRHLNDRKF 272
            +Q+I +++ ++++LH ++    GG+K+     RRR + L    F
Sbjct: 825 TKQQILKQRRRAQKLHFLQR---GGLKQLSARNRRRVQELQQGAF 866


>gi|164419743 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 1
           [Homo sapiens]
          Length = 882

 Score =  206 bits (523), Expect = 9e-53
 Identities = 127/380 (33%), Positives = 194/380 (51%), Gaps = 35/380 (9%)

Query: 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDR 461
           + + I K GYK PTPIQR+ IP+ L  +D++ +A TGSGKTA FL+P+   + T      
Sbjct: 107 VFKGIMKKGYKVPTPIQRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERLKT------ 160

Query: 462 IEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEI 521
              +  G  A+IL+PTRELA Q  + T + GK  G++T  ++GG   EDQ   L    +I
Sbjct: 161 -HSAQTGARALILSPTRELALQTLKFTKELGKFTGLKTALILGGDRMEDQFAALHENPDI 219

Query: 522 VIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDE 581
           +IATPGRL+ V     L L    YVV DEADR+ +MGF   +Q+I+  +P          
Sbjct: 220 IIATPGRLVHVAVEMSLKLQSVEYVVFDEADRLFEMGFAEQLQEIIARLP---------- 269

Query: 582 AEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQ 641
                        G H   QTV+F+AT+P  +   AR+ L  P ++ +    K +E+++ 
Sbjct: 270 -------------GGH---QTVLFSATLPKLLVEFARAGLTEPVLIRLDVDTKLNEQLKT 313

Query: 642 KVFLMSESEKRKKLLAILEQGFDP--PIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKG 699
             FL+ E  K   LL +L     P    ++FV  K   + L + L     +   ++    
Sbjct: 314 SFFLVREDTKAAVLLHLLHNVVRPQDQTVVFVATKHHAEYLTELLTTQRVSCAHIYSALD 373

Query: 700 QEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAG 759
              R+  L+    G    L+ TD+A RG+DI  +  V+NY      + ++HR+GR  RAG
Sbjct: 374 PTARKINLAKFTLGKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAG 433

Query: 760 KSGVAITFLTKEDSAVFYEL 779
           +SG A + +  ++     +L
Sbjct: 434 RSGTAYSLVAPDEIPYLLDL 453



 Score = 30.8 bits (68), Expect = 5.3
 Identities = 56/288 (19%), Positives = 114/288 (39%), Gaps = 38/288 (13%)

Query: 8   KKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGS---------- 57
           +KDR A    ++ ++ R   +E        S P+   K+    +    G           
Sbjct: 595 QKDRKAIARFQQGQQGRQEQQEGPVG-PAPSRPALQEKQPEKEEEEEAGESVEDIFSEVV 653

Query: 58  -RSRSRSRSKSAERERRHKERERDKE--RDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGK 114
            R R RS      + RR + R+RD+E       KD D ++      +       + G   
Sbjct: 654 GRKRQRSGPNRGAKRRREEARQRDQEFYIPYRPKDFDSERGLSISGEGGAFEQQAAGAVL 713

Query: 115 DFKSRKDRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEAL 174
           D    + ++  +  +    D+K K     + +   + K + + E+     S  +R+    
Sbjct: 714 DLMGDEAQNLTRGRQQLKWDRKKKR---FVGQSGQEDKKKIKTESGRYISSSYKRDLYQK 770

Query: 175 KRRQQEVEERQRMLE--EERK---KRKQFQDLGRKMLEDPQERERRERRERMERETNGNE 229
            +++Q++++R    E   +R+   +R   +D G+     P        R R E +T    
Sbjct: 771 WKQKQKIDDRDSDEEGASDRRGPERRGGKRDRGQAGASRPHAPGTPAGRVRPELKT---- 826

Query: 230 DEEGRQKIREEKDKSKELHAIKERYLGGIKK-----RRRTRHLNDRKF 272
               +Q+I +++ ++++LH ++    GG+K+     RRR + L    F
Sbjct: 827 ----KQQILKQRRRAQKLHFLQR---GGLKQLSARNRRRVQELQQGAF 867



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 34/201 (16%), Positives = 89/201 (44%), Gaps = 9/201 (4%)

Query: 37  KSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAERERRHKERERDKERDRNKKDRDRDKDG 96
           ++   KDRK      + + G + +       A      +E++ +KE +    +   D   
Sbjct: 591 RAKRQKDRKAIARFQQGQQGRQEQQEGPVGPAPSRPALQEKQPEKEEEEEAGESVEDIFS 650

Query: 97  HRRDKDRKRSSLSPGRGKDFKSRKDRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEE 156
               + R+RS   P RG     R+  ++++ +++ +   +PK         ++ +    E
Sbjct: 651 EVVGRKRQRS--GPNRG---AKRRREEARQRDQEFYIPYRPKDFDSERGLSISGEGGAFE 705

Query: 157 AEAKPKFLSKAEREAEALKRRQQEVE---ERQRML-EEERKKRKQFQDLGRKMLEDPQER 212
            +A    L     EA+ L R +Q+++   +++R + +  ++ +K+ +    + +    +R
Sbjct: 706 QQAAGAVLDLMGDEAQNLTRGRQQLKWDRKKKRFVGQSGQEDKKKIKTESGRYISSSYKR 765

Query: 213 ERRERRERMERETNGNEDEEG 233
           +  ++ ++ ++  + + DEEG
Sbjct: 766 DLYQKWKQKQKIDDRDSDEEG 786


>gi|83700235 eukaryotic translation initiation factor 4A2 [Homo
           sapiens]
          Length = 407

 Score =  202 bits (514), Expect = 1e-51
 Identities = 126/410 (30%), Positives = 211/410 (51%), Gaps = 38/410 (9%)

Query: 390 IRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPL 449
           + ++ D +L   +L  I   G+++P+ IQ++AI   ++  D+I  A++G+GKTA F I +
Sbjct: 32  VDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISI 91

Query: 450 LVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISRE 509
           L          ++E   +   A++LAPTRELAQQI++  +  G  +G    A IGG +  
Sbjct: 92  L---------QQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVR 142

Query: 510 DQGFRLRMGC-EIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILE 568
           ++  +L+     IV+ TPGR+ D+L  RYL        VLDEAD M+  GF+  + +I +
Sbjct: 143 NEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQ 202

Query: 569 HMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVY 628
            +  S Q                           V+ +ATMP  V  + + ++R P  + 
Sbjct: 203 KLNTSIQ--------------------------VVLLSATMPTDVLEVTKKFMRDPIRIL 236

Query: 629 IGSAGKPHERVEQKVFLMSESE-KRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKM 687
           +       E ++Q    +   E K   L  + E       +IF+N ++  D L + +   
Sbjct: 237 VKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHAR 296

Query: 688 GYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIED 747
            +    LHG   Q++R+  +   ++G+  +L+ TD+  RGID+Q VS+V+NYD+  N E+
Sbjct: 297 DFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNREN 356

Query: 748 YIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAILESPVSSCPPELAN 797
           YIHRIGR GR G+ GVAI F+T+ED  +  ++ +    + V   P  +A+
Sbjct: 357 YIHRIGRGGRFGRKGVAINFVTEEDKRILRDI-ETFYNTTVEEMPMNVAD 405


>gi|38569503 ATP-dependent RNA helicase ROK1 isoform b [Homo
           sapiens]
          Length = 491

 Score =  200 bits (509), Expect = 4e-51
 Identities = 139/459 (30%), Positives = 233/459 (50%), Gaps = 47/459 (10%)

Query: 345 KKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWK----DSSLPP 400
           K E K+   +   +  KL+ +        R  + I  +G  +P+PI +++    +  +  
Sbjct: 7   KIEDKKVQRESKLTSGKLENLRKEKINFLRNKHKIHVQGTDLPDPIATFQQLDQEYKINS 66

Query: 401 HILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKID 460
            +L+ I   G++ PTPIQ QAIP+ L  R+++  A TGSGKT AF IP+L+ +       
Sbjct: 67  RLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLK------ 120

Query: 461 RIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVI-GGISREDQGFRLRMGC 519
             + +++G  A+I++PTRELA QI  E IK  +  G R   +    ++ +  G +     
Sbjct: 121 --QPANKGFRALIISPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKF 178

Query: 520 EIVIATPGRLIDVLENRY--LVLSRCTYVVLDEADRMID---MGFEPDVQKILEHMPVSN 574
           +I++ TP RLI +L+     + L+   ++V+DE+D++ +    GF   +  I        
Sbjct: 179 DILVTTPNRLIYLLKQDPPGIDLASVEWLVVDESDKLFEDGKTGFRDQLASIF------- 231

Query: 575 QKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGK 634
                                 HK R+  MF+AT    VE+  +  L     V IG+   
Sbjct: 232 -----------------LACTSHKVRRA-MFSATFAYDVEQWCKLNLDNVISVSIGARNS 273

Query: 635 PHERVEQKV-FLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACT 693
             E VEQ++ F+ SE+ K   +  ++++GF+PP+++FV   +    L   L   G N   
Sbjct: 274 AVETVEQELLFVGSETGKLLAMRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDV 333

Query: 694 LHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIG 753
           +H  + Q+QR+  + + +AG   +L+ T +  RGID + V++V+NYD   +  +YIHRIG
Sbjct: 334 IHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIG 393

Query: 754 RTGRAGKSGVAITFLTKEDSAVFYELKQAILESPVSSCP 792
           RTGRAG  G AITF T++D  +   +   I +   + CP
Sbjct: 394 RTGRAGNKGKAITFFTEDDKPLLRSVANVIQQ---AGCP 429


>gi|4503529 eukaryotic translation initiation factor 4A isoform 1
           [Homo sapiens]
          Length = 406

 Score =  200 bits (508), Expect = 5e-51
 Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 37/393 (9%)

Query: 390 IRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPL 449
           + S+ D +L   +L  I   G+++P+ IQ++AI   ++  D+I  A++G+GKTA F I +
Sbjct: 31  VDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISI 90

Query: 450 LVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISRE 509
           L          +IE   +   A++LAPTRELAQQI++  +  G  +G    A IGG +  
Sbjct: 91  L---------QQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVR 141

Query: 510 DQGFRLRMGC-EIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILE 568
            +  +L+M    I++ TPGR+ D+L  RYL        VLDEAD M+  GF+  +  I +
Sbjct: 142 AEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQ 201

Query: 569 HMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVY 628
            +                          +   Q V+ +ATMP  V  + + ++R P  + 
Sbjct: 202 KL--------------------------NSNTQVVLLSATMPSDVLEVTKKFMRDPIRIL 235

Query: 629 IGSAGKPHERVEQKVFLMSESE-KRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKM 687
           +       E + Q    +   E K   L  + E       +IF+N ++  D L + +   
Sbjct: 236 VKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHAR 295

Query: 688 GYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIED 747
            +    +HG   Q++R+  +   ++G+  +L+ TD+  RGID+Q VS+V+NYD+  N E+
Sbjct: 296 DFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNREN 355

Query: 748 YIHRIGRTGRAGKSGVAITFLTKEDSAVFYELK 780
           YIHRIGR GR G+ GVAI  +T+ED     +++
Sbjct: 356 YIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIE 388


>gi|164664518 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Homo
           sapiens]
          Length = 483

 Score =  195 bits (496), Expect = 1e-49
 Identities = 129/414 (31%), Positives = 216/414 (52%), Gaps = 45/414 (10%)

Query: 360 KKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQR 419
           KK  ++  +D RI   D + +TKG +       ++D  L   +L  I + G+++P+PIQ 
Sbjct: 73  KKTLKLPPKDLRIKTSDVT-STKGNE-------FEDYCLKRELLMGIFEMGWEKPSPIQE 124

Query: 420 QAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRE 479
           ++IPI L  RDI+  A+ G+GK+ A+LIPLL         +R++       A+++ PTRE
Sbjct: 125 ESIPIALSGRDILARAKNGTGKSGAYLIPLL---------ERLDLKKDNIQAMVIVPTRE 175

Query: 480 LAQQIEEETIKFGKPLG-IRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYL 538
           LA Q+ +  I+  K +G  + +A  GG +  D   RL     +VIATPGR++D+++    
Sbjct: 176 LALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVA 235

Query: 539 VLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHK 598
            +     +VLDEAD+++   F   ++ I+  +P                          K
Sbjct: 236 KVDHVQMIVLDEADKLLSQDFVQIMEDIILTLP--------------------------K 269

Query: 599 YRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAI 658
            RQ ++++AT P +V++   S+L++P  + +       + V Q    ++E +K   L  +
Sbjct: 270 NRQILLYSATFPLSVQKFMNSHLQKPYEINLMEE-LTLKGVTQYYAYVTERQKVHCLNTL 328

Query: 659 LEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDIL 718
             +      IIF N  +  ++LAK + ++GY+   +H    QE R     + + G    L
Sbjct: 329 FSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNL 388

Query: 719 VATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKED 772
           V TD+  RGIDIQ V++V+N+D  K  E Y+HRIGR+GR G  G+AI  +T +D
Sbjct: 389 VCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDD 442


>gi|21040371 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 [Homo
           sapiens]
          Length = 427

 Score =  190 bits (483), Expect = 4e-48
 Identities = 125/418 (29%), Positives = 210/418 (50%), Gaps = 39/418 (9%)

Query: 382 KGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGK 441
           KG  +      ++D  L P +L  I  CG++ P+ +Q + IP  +   D++  A++G GK
Sbjct: 35  KGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGK 94

Query: 442 TAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPL-GIRTV 500
           TA F++  L          +IE  +     +++  TRELA QI +E  +F K +  ++  
Sbjct: 95  TAVFVLATL---------QQIEPVNGQVTVLVMCHTRELAFQISKEYERFSKYMPSVKVS 145

Query: 501 AVIGGISREDQGFRLRMGC-EIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMID-MG 558
              GG+S +     L+  C  +V+ TPGR++ ++ NR   L    + VLDE D+M++ + 
Sbjct: 146 VFFGGLSIKKDEEVLKKNCPHVVVGTPGRILALVRNRSFSLKNVKHFVLDECDKMLEQLD 205

Query: 559 FEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLAR 618
              DVQ+I    P                         H+ +Q +MF+AT+   +  + R
Sbjct: 206 MRRDVQEIFRLTP-------------------------HE-KQCMMFSATLSKDIRPVCR 239

Query: 619 SYLRRPAVVYIGSAGK-PHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGC 677
            +++ P  V++    K     ++Q    + +SEK +KL  +L+      +IIFV   + C
Sbjct: 240 KFMQDPMEVFVDDETKLTLHGLQQYYVKLKDSEKNRKLFDLLDVLEFNQVIIFVKSVQRC 299

Query: 678 DVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVV 737
             LA+ L +  + A  +H G  QE+R       K   + ILVAT++ GRG+DI+ V++V 
Sbjct: 300 MALAQLLVEQNFPAIAIHRGMAQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIVF 359

Query: 738 NYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAILESPVSSCPPEL 795
           NYDM ++ + Y+HR+ R GR G  G+AITF++ E+ A      Q   E  V+  P E+
Sbjct: 360 NYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNVAELPEEI 417


>gi|7661920 eukaryotic translation initiation factor 4A, isoform 3
           [Homo sapiens]
          Length = 411

 Score =  188 bits (477), Expect = 2e-47
 Identities = 114/382 (29%), Positives = 201/382 (52%), Gaps = 38/382 (9%)

Query: 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDR 461
           +L  I   G+++P+ IQ++AI   ++ RD+I  +++G+GKTA F I +L  +       +
Sbjct: 49  LLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDI-----Q 103

Query: 462 IEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEI 521
           + E+     A+ILAPTRELA QI++  +  G  + ++  A IGG +  +   +L  G  +
Sbjct: 104 VRETQ----ALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHV 159

Query: 522 VIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDE 581
           V  TPGR+ D++  R L       +VLDEAD M++ GF+  +  +  ++P + Q      
Sbjct: 160 VAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQ------ 213

Query: 582 AEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQ 641
                                V+ +AT+P  +  +   ++  P  + +       E ++Q
Sbjct: 214 --------------------VVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQ 253

Query: 642 KVFLMSESEKRK--KLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKG 699
             F+  E E+ K   L  + +       +IF N K+  D L + + +  +   ++HG   
Sbjct: 254 -FFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMP 312

Query: 700 QEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAG 759
           Q++RE  +   ++GA  +L++TDV  RG+D+  VS+++NYD+  N E YIHRIGR+GR G
Sbjct: 313 QKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYG 372

Query: 760 KSGVAITFLTKEDSAVFYELKQ 781
           + GVAI F+  +D  +  +++Q
Sbjct: 373 RKGVAINFVKNDDIRILRDIEQ 394


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,972,905
Number of Sequences: 37866
Number of extensions: 1685661
Number of successful extensions: 44988
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 844
Number of HSP's successfully gapped in prelim test: 1151
Number of HSP's that attempted gapping in prelim test: 9370
Number of HSP's gapped (non-prelim): 12491
length of query: 820
length of database: 18,247,518
effective HSP length: 111
effective length of query: 709
effective length of database: 14,044,392
effective search space: 9957473928
effective search space used: 9957473928
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.