Search of human proteins with 41281821

Search of human proteins with 41281821

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]
         (860 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]        1723   0.0  
gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens]       1379   0.0  
gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]       1355   0.0  
gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens]       1354   0.0  
gi|216547779 SH2 domain containing 3C isoform c [Homo sapiens]       1011   0.0  
gi|216547769 SH2 domain containing 3C isoform c [Homo sapiens]       1011   0.0  
gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]     554   e-157
gi|208609985 SH2 domain containing 3A [Homo sapiens]                  315   9e-86
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]      74   8e-13
gi|194239668 SHC (Src homology 2 domain containing) transforming...    60   9e-09
gi|194239662 SHC (Src homology 2 domain containing) transforming...    60   9e-09
gi|194239664 SHC (Src homology 2 domain containing) transforming...    59   1e-08
gi|32261324 SHC (Src homology 2 domain containing) transforming ...    59   1e-08
gi|222446609 rai-like protein [Homo sapiens]                           56   2e-07
gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik...    55   2e-07
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]          55   2e-07
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]            55   2e-07
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ...    55   2e-07
gi|169790811 SHC (Src homology 2 domain containing) transforming...    55   2e-07
gi|224586793 src homology 2 domain-containing transforming prote...    53   1e-06
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]              50   7e-06
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]                50   7e-06
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]              50   7e-06
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]              50   7e-06
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]              50   7e-06
gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]           50   9e-06
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...    50   1e-05
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...    50   1e-05
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             50   1e-05
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom...    49   2e-05

>gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]
          Length = 860

 Score = 1723 bits (4462), Expect = 0.0
 Identities = 860/860 (100%), Positives = 860/860 (100%)

Query: 1   MTEGTKKTSKKFKFFKFKGFGSLSNLPRSFTLRRSSASISRQSHLEPDTFEATQDDMVTV 60
           MTEGTKKTSKKFKFFKFKGFGSLSNLPRSFTLRRSSASISRQSHLEPDTFEATQDDMVTV
Sbjct: 1   MTEGTKKTSKKFKFFKFKGFGSLSNLPRSFTLRRSSASISRQSHLEPDTFEATQDDMVTV 60

Query: 61  PKSPPAYARSSDMYSHMGTMPRPSIKKAQNSQAARQAQEAGPKPNLVPGGVPDPPGLEAA 120
           PKSPPAYARSSDMYSHMGTMPRPSIKKAQNSQAARQAQEAGPKPNLVPGGVPDPPGLEAA
Sbjct: 61  PKSPPAYARSSDMYSHMGTMPRPSIKKAQNSQAARQAQEAGPKPNLVPGGVPDPPGLEAA 120

Query: 121 KEVMVKATGPLEDTPAMEPNPSAVEVDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAG 180
           KEVMVKATGPLEDTPAMEPNPSAVEVDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAG
Sbjct: 121 KEVMVKATGPLEDTPAMEPNPSAVEVDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAG 180

Query: 181 SDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDF 240
           SDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDF
Sbjct: 181 SDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDF 240

Query: 241 LIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYH 300
           LIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYH
Sbjct: 241 LIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYH 300

Query: 301 VGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSV 360
           VGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSV
Sbjct: 301 VGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSV 360

Query: 361 TMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYS 420
           TMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYS
Sbjct: 361 TMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYS 420

Query: 421 TVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASP 480
           TVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASP
Sbjct: 421 TVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASP 480

Query: 481 SPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGK 540
           SPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGK
Sbjct: 481 SPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGK 540

Query: 541 TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCL 600
           TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCL
Sbjct: 541 TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCL 600

Query: 601 VARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEE 660
           VARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEE
Sbjct: 601 VARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEE 660

Query: 661 RAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEK 720
           RAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEK
Sbjct: 661 RAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEK 720

Query: 721 KLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHL 780
           KLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHL
Sbjct: 721 KLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHL 780

Query: 781 EAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKF 840
           EAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKF
Sbjct: 781 EAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKF 840

Query: 841 DKVLTALSHKLEPAVRSSEL 860
           DKVLTALSHKLEPAVRSSEL
Sbjct: 841 DKVLTALSHKLEPAVRSSEL 860


>gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens]
          Length = 703

 Score = 1379 bits (3569), Expect = 0.0
 Identities = 689/691 (99%), Positives = 689/691 (99%)

Query: 170 SERAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREV 229
           S  AAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREV
Sbjct: 13  SRGAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREV 72

Query: 230 SETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQES 289
           SETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQES
Sbjct: 73  SETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQES 132

Query: 290 FDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSG 349
           FDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSG
Sbjct: 133 FDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSG 192

Query: 350 PKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSP 409
           PKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSP
Sbjct: 193 PKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSP 252

Query: 410 ISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHT 469
           ISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHT
Sbjct: 253 ISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHT 312

Query: 470 SPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELS 529
           SPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELS
Sbjct: 313 SPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELS 372

Query: 530 ENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDART 589
           ENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDART
Sbjct: 373 ENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDART 432

Query: 590 LARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAV 649
           LARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAV
Sbjct: 433 LARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAV 492

Query: 650 DILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQ 709
           DILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQ
Sbjct: 493 DILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQ 552

Query: 710 RHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGST 769
           RHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGST
Sbjct: 553 RHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGST 612

Query: 770 EHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGA 829
           EHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGA
Sbjct: 613 EHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGA 672

Query: 830 SSSQARRYEKFDKVLTALSHKLEPAVRSSEL 860
           SSSQARRYEKFDKVLTALSHKLEPAVRSSEL
Sbjct: 673 SSSQARRYEKFDKVLTALSHKLEPAVRSSEL 703


>gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]
          Length = 700

 Score = 1355 bits (3508), Expect = 0.0
 Identities = 676/678 (99%), Positives = 678/678 (100%)

Query: 183 YVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLI 242
           +V+FSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLI
Sbjct: 23  FVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLI 82

Query: 243 RDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVG 302
           RDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVG
Sbjct: 83  RDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVG 142

Query: 303 SRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTM 362
           SRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTM
Sbjct: 143 SRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTM 202

Query: 363 TDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTV 422
           TDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTV
Sbjct: 203 TDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTV 262

Query: 423 TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSP 482
           TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSP
Sbjct: 263 TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSP 322

Query: 483 SLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTF 542
           SLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTF
Sbjct: 323 SLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTF 382

Query: 543 TVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVA 602
           TVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVA
Sbjct: 383 TVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVA 442

Query: 603 RILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERA 662
           RILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERA
Sbjct: 443 RILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERA 502

Query: 663 ALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKL 722
           ALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKL
Sbjct: 503 ALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKL 562

Query: 723 KPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEA 782
           KPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEA
Sbjct: 563 KPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEA 622

Query: 783 ARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDK 842
           ARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDK
Sbjct: 623 ARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDK 682

Query: 843 VLTALSHKLEPAVRSSEL 860
           VLTALSHKLEPAVRSSEL
Sbjct: 683 VLTALSHKLEPAVRSSEL 700


>gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens]
          Length = 702

 Score = 1354 bits (3505), Expect = 0.0
 Identities = 676/677 (99%), Positives = 677/677 (100%)

Query: 184 VKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIR 243
           V+FSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIR
Sbjct: 26  VQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIR 85

Query: 244 DSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGS 303
           DSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGS
Sbjct: 86  DSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGS 145

Query: 304 RKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMT 363
           RKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMT
Sbjct: 146 RKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMT 205

Query: 364 DGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVT 423
           DGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVT
Sbjct: 206 DGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVT 265

Query: 424 RVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPS 483
           RVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPS
Sbjct: 266 RVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPS 325

Query: 484 LSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFT 543
           LSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFT
Sbjct: 326 LSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFT 385

Query: 544 VPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVAR 603
           VPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVAR
Sbjct: 386 VPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVAR 445

Query: 604 ILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAA 663
           ILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAA
Sbjct: 446 ILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAA 505

Query: 664 LLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLK 723
           LLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLK
Sbjct: 506 LLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLK 565

Query: 724 PFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAA 783
           PFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAA
Sbjct: 566 PFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAA 625

Query: 784 RTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKV 843
           RTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKV
Sbjct: 626 RTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKV 685

Query: 844 LTALSHKLEPAVRSSEL 860
           LTALSHKLEPAVRSSEL
Sbjct: 686 LTALSHKLEPAVRSSEL 702


>gi|216547779 SH2 domain containing 3C isoform c [Homo sapiens]
          Length = 506

 Score = 1011 bits (2613), Expect = 0.0
 Identities = 506/506 (100%), Positives = 506/506 (100%)

Query: 355 MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESP 414
           MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESP
Sbjct: 1   MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESP 60

Query: 415 SSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHT 474
           SSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHT
Sbjct: 61  SSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHT 120

Query: 475 LGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAP 534
           LGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAP
Sbjct: 121 LGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAP 180

Query: 535 EGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHV 594
           EGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHV
Sbjct: 181 EGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHV 240

Query: 595 TKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGC 654
           TKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGC
Sbjct: 241 TKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGC 300

Query: 655 TGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEG 714
           TGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEG
Sbjct: 301 TGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEG 360

Query: 715 AILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVE 774
           AILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVE
Sbjct: 361 AILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVE 420

Query: 775 VVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQA 834
           VVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQA
Sbjct: 421 VVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQA 480

Query: 835 RRYEKFDKVLTALSHKLEPAVRSSEL 860
           RRYEKFDKVLTALSHKLEPAVRSSEL
Sbjct: 481 RRYEKFDKVLTALSHKLEPAVRSSEL 506


>gi|216547769 SH2 domain containing 3C isoform c [Homo sapiens]
          Length = 506

 Score = 1011 bits (2613), Expect = 0.0
 Identities = 506/506 (100%), Positives = 506/506 (100%)

Query: 355 MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESP 414
           MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESP
Sbjct: 1   MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESP 60

Query: 415 SSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHT 474
           SSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHT
Sbjct: 61  SSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHT 120

Query: 475 LGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAP 534
           LGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAP
Sbjct: 121 LGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAP 180

Query: 535 EGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHV 594
           EGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHV
Sbjct: 181 EGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHV 240

Query: 595 TKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGC 654
           TKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGC
Sbjct: 241 TKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGC 300

Query: 655 TGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEG 714
           TGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEG
Sbjct: 301 TGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEG 360

Query: 715 AILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVE 774
           AILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVE
Sbjct: 361 AILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVE 420

Query: 775 VVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQA 834
           VVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQA
Sbjct: 421 VVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQA 480

Query: 835 RRYEKFDKVLTALSHKLEPAVRSSEL 860
           RRYEKFDKVLTALSHKLEPAVRSSEL
Sbjct: 481 RRYEKFDKVLTALSHKLEPAVRSSEL 506


>gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]
          Length = 825

 Score =  554 bits (1428), Expect = e-157
 Identities = 331/752 (44%), Positives = 456/752 (60%), Gaps = 59/752 (7%)

Query: 156 TGDVEEERPPRDVHSE----RAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLS 211
           T D  +E P +D H E    R     +   +YVKFSKE++I+D +PEKL KELEEEL LS
Sbjct: 86  TQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKELEEELLLS 145

Query: 212 STDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVV 271
           S DLRSHAWYHGRIPR+VSE LVQR+GDFL+RDSL+S G++VLTC+W+N A HFKIN+ V
Sbjct: 146 SEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTV 205

Query: 272 VKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEAS 331
           ++  E+Y+ +QY FE ESFD +P LVR +VG+R+ +S+QSGAII+ P+NRT PLR LE  
Sbjct: 206 LRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEH 265

Query: 332 YGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIR 391
           YG   G ++  S ++   P  +  KR S+TM  G+ A    R    P    L R ++   
Sbjct: 266 YGTSPGQAREGS-LTKGRPDVA--KRLSLTM-GGVQA----REQNLPRGNLL-RNKEKSG 316

Query: 392 SCALSMDQIPDLHSPMSPISESPSSPAYSTV-TRVHAAPAAPSATALPASPVARRSSEPQ 450
           S    +D + D  +      +S S   Y  +  ++    +    +  P SPV R  SEP 
Sbjct: 317 SQPACLDHMQDRRALSLKAHQSES---YLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPA 373

Query: 451 LCPGSAPKTHGESDKGP--HTSPSHTLGKASPSPS----LSSYSDPDS-----GHYCQLQ 499
           L P    +   ++  G     S S    K  P P     L   S P +      +YC+L 
Sbjct: 374 LSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELN 433

Query: 500 PPV-----RGSREWAATETSSQQA-----------RSYG-----------ERLKELSENG 532
           P       RG++  +  + S  +            R+ G           ER  E +   
Sbjct: 434 PAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQ 493

Query: 533 APEGDWGK-TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLA 591
             +G W K  F  P++E  SSF P  F+S  +P +N+PLE  +L++ KEL    D + +A
Sbjct: 494 MEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIA 553

Query: 592 RHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDI 651
           +HV  +DC VARILGV++EM+  MGV  G+EL+TLPHG QLRLD++ER +TM+I +AVDI
Sbjct: 554 QHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDI 613

Query: 652 LGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRH 711
           LGCTG+ E+RAA L K IQ+A EL+ +MG+++SF+A+M AL+M QI+RLE+TW  LR ++
Sbjct: 614 LGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALRHQY 673

Query: 712 TEGAILYEKKLKPFLKSLNEGKEGP--PLSNTTFPHVLPLITLLECDSAPPEGPEPWGST 769
           T+ AILYEK+LKPF K L+EG+E    P +N + P ++PL+TL+E  +   EG + W   
Sbjct: 674 TQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKN 733

Query: 770 EHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGA 829
           +   E++L HL  AR +A     Y  NAE  L GFQ   E+ E+  TEFQMRLLWGS+GA
Sbjct: 734 DQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGA 793

Query: 830 SSSQARRYEKFDKVLTALSHKLE-PAVRSSEL 860
             +Q  RYEKF+++LTALS KLE P V+ +EL
Sbjct: 794 QVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825


>gi|208609985 SH2 domain containing 3A [Homo sapiens]
          Length = 576

 Score =  315 bits (808), Expect = 9e-86
 Identities = 219/646 (33%), Positives = 320/646 (49%), Gaps = 86/646 (13%)

Query: 214 DLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 273
           DL    WYHG + R+ +E L+Q+NGDFL+R S +  G+ V++CRWR  ALHF++ +V ++
Sbjct: 9   DLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALR 68

Query: 274 AGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYG 333
                    +  E E F  +PALV  ++  R+ +S+ +GA++                  
Sbjct: 69  PRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVV------------------ 110

Query: 334 LGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSC 393
                   + PV+  GP      RRS +        + T  DG       P   + +R+ 
Sbjct: 111 --------SRPVTWQGPL-----RRSFS--------EDTLMDG-------PARIEPLRAR 142

Query: 394 ALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCP 453
             S  Q  DL                + + R    PA   A+ +P S + R SS+P L  
Sbjct: 143 KWSNSQPADL----------------AHMGRSREDPAGMEASTMPISALPRTSSDPVLLK 186

Query: 454 GSAPKTHGESDKGPHTSPSHTLGKASPSPSLS-SYSDPDSGH----YCQLQPPVRGSREW 508
             AP   G        S      KA   P  + S+  PD+      YC+L P V   +  
Sbjct: 187 APAPL--GTVADSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGT 244

Query: 509 AATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNR 568
           + +++  +    + E  ++  E         + FT P  E+  SF P    S L+   NR
Sbjct: 245 SPSQSCPEPEAPWWEAEEDEEEEN-------RCFTRPQAEI--SFCPHDAPSCLLGPQNR 295

Query: 569 PLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPH 628
           PLE  +L  ++ L  E    + A H+  VDC    +LGVT++ +  MGV  G+ELLTLPH
Sbjct: 296 PLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPH 355

Query: 629 GRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELR-GTMGNMFSFAA 687
           G  LRL+LLER  T+++  A+ +LGC+G  EERAA L   ++LA  LR G  G++   AA
Sbjct: 356 GHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAA 415

Query: 688 VMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVL 747
           VMGAL M Q+SRLE TW  LR+ HTE A+ +E++LKP +++L+EG           PHV 
Sbjct: 416 VMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVA 475

Query: 748 PLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQAR 807
           P++ LL       EG E  G  +   E +L  L  AR +      +   A  +L+GF+  
Sbjct: 476 PMVRLL-------EGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPN 528

Query: 808 PELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEP 853
           PEL E  +T F  RLLWGS+GA + +A R+EKF +VL  LS +LEP
Sbjct: 529 PELREALTTGFVRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEP 574


>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
          Length = 822

 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 36/116 (31%), Positives = 62/116 (53%), Gaps = 9/116 (7%)

Query: 204 LEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQAL 263
           L + + +S   L    WYHG IPR  ++ L+++ GDFL+R+S    G+YVL+     Q  
Sbjct: 444 LSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRR 503

Query: 264 HFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPV 319
           HF I          Y    Y FE   F ++P L+ +H  +++ ++++SG ++  P+
Sbjct: 504 HFII---------QYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPI 550


>gi|194239668 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 4 [Homo sapiens]
          Length = 473

 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 58/215 (26%), Positives = 90/215 (41%), Gaps = 21/215 (9%)

Query: 101 GPKPNLVPGGVPDPPGLEAAKEVMVKATGPLEDTP----AMEPNPSAVEVDP-IRK---- 151
           G +P L  GGV D    E A     + T P   TP    A  P    V  DP +RK    
Sbjct: 245 GKEPPL--GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPP 302

Query: 152 -PEVPTGDVEEERPPRDVHS----ERAAGEPEAGSDYVKFSKEKYILDSSP--EKLHKEL 204
            P  P  ++ ++    +V +     +A G     +  +  S  + + D  P  + L    
Sbjct: 303 PPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPP 362

Query: 205 EEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALH 264
             +    +  LR   W+HG++ R  +E L+Q NGDFL+R+S T+ G YVLT     Q  H
Sbjct: 363 PPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKH 422

Query: 265 FKI---NKVVVKAGESYTHIQYLFEQESFDHVPAL 296
             +     VV      +  + +L      +H+P +
Sbjct: 423 LLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPII 457


>gi|194239662 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 1 [Homo sapiens]
          Length = 583

 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 58/215 (26%), Positives = 90/215 (41%), Gaps = 21/215 (9%)

Query: 101 GPKPNLVPGGVPDPPGLEAAKEVMVKATGPLEDTP----AMEPNPSAVEVDP-IRK---- 151
           G +P L  GGV D    E A     + T P   TP    A  P    V  DP +RK    
Sbjct: 355 GKEPPL--GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPP 412

Query: 152 -PEVPTGDVEEERPPRDVHS----ERAAGEPEAGSDYVKFSKEKYILDSSP--EKLHKEL 204
            P  P  ++ ++    +V +     +A G     +  +  S  + + D  P  + L    
Sbjct: 413 PPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPP 472

Query: 205 EEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALH 264
             +    +  LR   W+HG++ R  +E L+Q NGDFL+R+S T+ G YVLT     Q  H
Sbjct: 473 PPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKH 532

Query: 265 FKI---NKVVVKAGESYTHIQYLFEQESFDHVPAL 296
             +     VV      +  + +L      +H+P +
Sbjct: 533 LLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPII 567


>gi|194239664 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 3 [Homo sapiens]
          Length = 584

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 60/216 (27%), Positives = 89/216 (41%), Gaps = 22/216 (10%)

Query: 101 GPKPNLVPGGVPDPPGLEAAKEVMVKATGPLEDTP----AMEPNPSAVEVDP-IRK---- 151
           G +P L  GGV D    E A     + T P   TP    A  P    V  DP +RK    
Sbjct: 355 GKEPPL--GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPP 412

Query: 152 -PEVPTGDVEEERPP----RDVHSER-AAGEPEAGSDYVKFSKEKYILDSSP--EKLHKE 203
            P  P G    + P     +++   R A G     +  +  S  + + D  P  + L   
Sbjct: 413 PPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVP 472

Query: 204 LEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQAL 263
              +    +  LR   W+HG++ R  +E L+Q NGDFL+R+S T+ G YVLT     Q  
Sbjct: 473 PPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPK 532

Query: 264 HFKI---NKVVVKAGESYTHIQYLFEQESFDHVPAL 296
           H  +     VV      +  + +L      +H+P +
Sbjct: 533 HLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPII 568


>gi|32261324 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 2 [Homo sapiens]
          Length = 474

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 60/216 (27%), Positives = 89/216 (41%), Gaps = 22/216 (10%)

Query: 101 GPKPNLVPGGVPDPPGLEAAKEVMVKATGPLEDTP----AMEPNPSAVEVDP-IRK---- 151
           G +P L  GGV D    E A     + T P   TP    A  P    V  DP +RK    
Sbjct: 245 GKEPPL--GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPP 302

Query: 152 -PEVPTGDVEEERPP----RDVHSER-AAGEPEAGSDYVKFSKEKYILDSSP--EKLHKE 203
            P  P G    + P     +++   R A G     +  +  S  + + D  P  + L   
Sbjct: 303 PPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVP 362

Query: 204 LEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQAL 263
              +    +  LR   W+HG++ R  +E L+Q NGDFL+R+S T+ G YVLT     Q  
Sbjct: 363 PPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPK 422

Query: 264 HFKI---NKVVVKAGESYTHIQYLFEQESFDHVPAL 296
           H  +     VV      +  + +L      +H+P +
Sbjct: 423 HLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPII 458


>gi|222446609 rai-like protein [Homo sapiens]
          Length = 630

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 38/108 (35%), Positives = 58/108 (53%), Gaps = 10/108 (9%)

Query: 215 LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKA 274
           L S   YHG++ R+ +E+L+ ++GDFL+R+S TS G YVL+     QA H  +   V   
Sbjct: 521 LWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLL---VDPE 577

Query: 275 GESYTHIQYLFEQESFDHVPALVRYHV-GSRKAVSEQSGAIIYCPVNR 321
           G+  T      +   FD+V  L+RYH+  S   +S  S   +  PV +
Sbjct: 578 GKVRT------KDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619


>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
           [Homo sapiens]
          Length = 303

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 30/84 (35%), Positives = 49/84 (58%), Gaps = 10/84 (11%)

Query: 219 AWYHGRIPREVSETLVQ--RNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGE 276
           AWY G + R+ ++T +Q  R+G FL+RDS T  GDYVL+    ++  H+ IN        
Sbjct: 13  AWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIIN-------- 64

Query: 277 SYTHIQYLFEQESFDHVPALVRYH 300
           S  + ++    + FDH+PAL+ ++
Sbjct: 65  SLPNRRFKIGDQEFDHLPALLEFY 88


>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
          Length = 764

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 35/103 (33%), Positives = 58/103 (56%), Gaps = 12/103 (11%)

Query: 215 LRSHAWYHGRIPR-EVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 273
           L    WYHG IPR EV+E LV  +GDFL+R+S     +YVL+  W     HF I      
Sbjct: 397 LHEQLWYHGAIPRAEVAELLV-HSGDFLVRES-QGKQEYVLSVLWDGLPRHFII------ 448

Query: 274 AGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIY 316
             +S  ++ Y  E E F  +P L+ + + +++ ++++SG +++
Sbjct: 449 --QSLDNL-YRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 488


>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
          Length = 822

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 35/103 (33%), Positives = 58/103 (56%), Gaps = 12/103 (11%)

Query: 215 LRSHAWYHGRIPR-EVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 273
           L    WYHG IPR EV+E LV  +GDFL+R+S     +YVL+  W     HF I      
Sbjct: 455 LHEQLWYHGAIPRAEVAELLV-HSGDFLVRES-QGKQEYVLSVLWDGLPRHFII------ 506

Query: 274 AGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIY 316
             +S  ++ Y  E E F  +P L+ + + +++ ++++SG +++
Sbjct: 507 --QSLDNL-YRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 546


>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
           sapiens]
          Length = 475

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 24/50 (48%), Positives = 33/50 (66%)

Query: 215 LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALH 264
           LR   WYHGR+ R  +E +++ +GDFL+RDS+T+ G YVLT     Q  H
Sbjct: 375 LRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKH 424


>gi|169790811 SHC (Src homology 2 domain containing) transforming
           protein 2 [Homo sapiens]
          Length = 582

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 24/50 (48%), Positives = 33/50 (66%)

Query: 215 LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALH 264
           LR   WYHGR+ R  +E +++ +GDFL+RDS+T+ G YVLT     Q  H
Sbjct: 482 LRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKH 531


>gi|224586793 src homology 2 domain-containing transforming protein
           C3 [Homo sapiens]
          Length = 594

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 35/109 (32%), Positives = 55/109 (50%), Gaps = 10/109 (9%)

Query: 214 DLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 273
           +L++  WY G + R+ +E L++++GDFL+R S T+ G +VLT     QA H  +   V  
Sbjct: 493 ELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLL---VDP 549

Query: 274 AGESYTHIQYLFEQESFDHVPALVRYHV-GSRKAVSEQSGAIIYCPVNR 321
            G   T      +   FD +  L+ +H+  S   VS  S   +  PV R
Sbjct: 550 EGTIRT------KDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVER 592


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 7/82 (8%)

Query: 215 LRSHAWYHGRIPREVSETLVQR--NGDFLIRDSLTSLGDYVLTCRWRNQALHFKIN---- 268
           L  H+WYHG + R  +E L+    NG FL+R+S +S G   ++ R+  +  H++IN    
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 212

Query: 269 -KVVVKAGESYTHIQYLFEQES 289
            KV V A   ++ +  L    S
Sbjct: 213 GKVYVTAESRFSTLAELVHHHS 234


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 7/82 (8%)

Query: 215 LRSHAWYHGRIPREVSETLVQR--NGDFLIRDSLTSLGDYVLTCRWRNQALHFKIN---- 268
           L  H+WYHG + R  +E L+    NG FL+R+S +S G   ++ R+  +  H++IN    
Sbjct: 168 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 227

Query: 269 -KVVVKAGESYTHIQYLFEQES 289
            KV V A   ++ +  L    S
Sbjct: 228 GKVYVTAESRFSTLAELVHHHS 249


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 7/82 (8%)

Query: 215 LRSHAWYHGRIPREVSETLVQR--NGDFLIRDSLTSLGDYVLTCRWRNQALHFKIN---- 268
           L  H+WYHG + R  +E L+    NG FL+R+S +S G   ++ R+  +  H++IN    
Sbjct: 147 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 206

Query: 269 -KVVVKAGESYTHIQYLFEQES 289
            KV V A   ++ +  L    S
Sbjct: 207 GKVYVTAESRFSTLAELVHHHS 228


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 7/82 (8%)

Query: 215 LRSHAWYHGRIPREVSETLVQR--NGDFLIRDSLTSLGDYVLTCRWRNQALHFKIN---- 268
           L  H+WYHG + R  +E L+    NG FL+R+S +S G   ++ R+  +  H++IN    
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 212

Query: 269 -KVVVKAGESYTHIQYLFEQES 289
            KV V A   ++ +  L    S
Sbjct: 213 GKVYVTAESRFSTLAELVHHHS 234


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 7/82 (8%)

Query: 215 LRSHAWYHGRIPREVSETLVQR--NGDFLIRDSLTSLGDYVLTCRWRNQALHFKIN---- 268
           L  H+WYHG + R  +E L+    NG FL+R+S +S G   ++ R+  +  H++IN    
Sbjct: 132 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 191

Query: 269 -KVVVKAGESYTHIQYLFEQES 289
            KV V A   ++ +  L    S
Sbjct: 192 GKVYVTAESRFSTLAELVHHHS 213


>gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]
          Length = 683

 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 54/242 (22%), Positives = 91/242 (37%), Gaps = 32/242 (13%)

Query: 127 ATGPLEDTPAMEPNPSAVEVDP-------IRKPEVPTGDVEEERPPRDVHSERAAGEPEA 179
           A G L D P+   +PS+  +         +  PE+P     EE PP       +A  P  
Sbjct: 438 AYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPL 497

Query: 180 GSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGD 239
             D  + +   ++    PE    +           L  + W+HG + R  +  LV   G 
Sbjct: 498 --DTPETATGSFLFQGEPEGGEGD---------QPLSGYPWFHGMLSRLKAAQLVLTGGT 546

Query: 240 -----FLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVP 294
                FL+R S T  G+YVLT  ++ +A H +++       E    +Q+L+ Q  FD + 
Sbjct: 547 GSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLS----LNEEGQCRVQHLWFQSIFDMLE 602

Query: 295 ALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSH 354
               + +      S     + Y P ++       +       G   P  P S +G +   
Sbjct: 603 HFRVHPIPLESGGSSDVVLVSYVPSSQR-----QQGEQSRSAGEEVPVHPRSEAGSRLGA 657

Query: 355 MK 356
           M+
Sbjct: 658 MR 659


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 27/88 (30%), Positives = 46/88 (52%), Gaps = 9/88 (10%)

Query: 215 LRSHAWYHGRIPREVSETLVQR--NGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVV 272
           L  H+WYHG + R  +E L+    NG FL+R+S +S G   ++ R+  +  H++IN    
Sbjct: 122 LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN--TA 179

Query: 273 KAGESYTHIQYLFEQESFDHVPALVRYH 300
             G+      Y+  +  F+ +  LV +H
Sbjct: 180 SDGK-----LYVSSESRFNTLAELVHHH 202


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 27/88 (30%), Positives = 46/88 (52%), Gaps = 9/88 (10%)

Query: 215 LRSHAWYHGRIPREVSETLVQR--NGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVV 272
           L  H+WYHG + R  +E L+    NG FL+R+S +S G   ++ R+  +  H++IN    
Sbjct: 141 LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN--TA 198

Query: 273 KAGESYTHIQYLFEQESFDHVPALVRYH 300
             G+      Y+  +  F+ +  LV +H
Sbjct: 199 SDGK-----LYVSSESRFNTLAELVHHH 221


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 54/194 (27%), Positives = 79/194 (40%), Gaps = 30/194 (15%)

Query: 338  SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSM 397
            SS PAS  +P+    S     SVT+   L +  +        STS P P           
Sbjct: 1831 SSAPASAPAPTPILASVSTPASVTI---LASASIPILASALASTSAPTPA---------- 1877

Query: 398  DQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAP 457
               P   SP +P+  +P+ PA +    V  APA+ SA A   +PV    S P   P +  
Sbjct: 1878 ---PAASSPAAPVITAPTIPASAPTASVPLAPASASAPAPAPTPV----SAPNPAPPAPA 1930

Query: 458  KTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ 517
            +T  ++ K P  +P  T  ++S  P       P S      Q P     ++ A+  S Q 
Sbjct: 1931 QTQAQTHK-PVQNPLQTTSQSSKQP-------PPSIRLPSAQTP--NGTDYVASGKSIQT 1980

Query: 518  ARSYGERLKELSEN 531
             +S+G    EL +N
Sbjct: 1981 PQSHGTLTAELWDN 1994



 Score = 37.0 bits (84), Expect = 0.078
 Identities = 35/120 (29%), Positives = 52/120 (43%), Gaps = 11/120 (9%)

Query: 374  SDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPA-YSTVTRVHAAPAAP 432
            S   P   S P P  +  S   S      L + ++P+  S S+P   ST+  V A+ +AP
Sbjct: 1743 SASVPPLASAPLPPSTSASVPASTSA--PLPATLTPVPASTSAPVPASTLAPVLASTSAP 1800

Query: 433  SATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDS 492
               A P +PV+  +S     P S       S   P ++P       +P+P L+S S P S
Sbjct: 1801 -VPASPLAPVSASASVSASVPASTSAAAITSSSAPASAP-------APTPILASVSTPAS 1852



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 9/87 (10%)

Query: 378  PTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISES-------PSSPAYSTVTRVHAAPA 430
            P STS P P  ++    L+    P   SP++P+S S       P+S + + +T   A  +
Sbjct: 1778 PASTSAPVPASTLAP-VLASTSAPVPASPLAPVSASASVSASVPASTSAAAITSSSAPAS 1836

Query: 431  APSATALPASPVARRSSEPQLCPGSAP 457
            AP+ T + AS V+  +S   L   S P
Sbjct: 1837 APAPTPILAS-VSTPASVTILASASIP 1862


>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
           sapiens]
          Length = 217

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 29/100 (29%), Positives = 55/100 (55%), Gaps = 11/100 (11%)

Query: 214 DLRSHAWYHGRIPREVSETLVQR---NGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKV 270
           +++ H W+ G+IPR  +E ++ +   +G FLIR+S ++ GD+ L+ ++ N   HFK    
Sbjct: 54  EMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFK---- 109

Query: 271 VVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQ 310
           V++ G      +Y      F+ +  LV YH  +  + ++Q
Sbjct: 110 VLRDGAG----KYFLWVVKFNSLNELVDYHRSTSVSRNQQ 145


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,757,735
Number of Sequences: 37866
Number of extensions: 2028352
Number of successful extensions: 9502
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 89
Number of HSP's successfully gapped in prelim test: 564
Number of HSP's that attempted gapping in prelim test: 8087
Number of HSP's gapped (non-prelim): 1735
length of query: 860
length of database: 18,247,518
effective HSP length: 111
effective length of query: 749
effective length of database: 14,044,392
effective search space: 10519249608
effective search space used: 10519249608
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.