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Search of human proteins with 41281753
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
(470 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 940 0.0
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 932 0.0
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 932 0.0
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 229 4e-60
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 220 2e-57
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 220 2e-57
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 220 2e-57
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 218 1e-56
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 214 2e-55
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 181 1e-45
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 176 4e-44
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 171 2e-42
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 167 2e-41
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 167 2e-41
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 163 4e-40
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 142 5e-34
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 139 4e-33
gi|93004081 polo-like kinase 2 [Homo sapiens] 137 3e-32
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 134 1e-31
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 134 2e-31
gi|21359873 polo-like kinase 1 [Homo sapiens] 132 5e-31
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 130 3e-30
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 130 3e-30
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 129 4e-30
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 127 2e-29
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 127 2e-29
gi|41872374 polo-like kinase 3 [Homo sapiens] 127 3e-29
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho... 123 3e-28
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 123 4e-28
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 120 2e-27
>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
Length = 470
Score = 940 bits (2429), Expect = 0.0
Identities = 470/470 (100%), Positives = 470/470 (100%)
Query: 1 MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL 60
MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL
Sbjct: 1 MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL 60
Query: 61 KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI 120
KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI
Sbjct: 61 KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI 120
Query: 121 QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR 180
QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR
Sbjct: 121 QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR 180
Query: 181 LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI 240
LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI
Sbjct: 181 LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI 240
Query: 241 VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE 300
VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE
Sbjct: 241 VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE 300
Query: 301 MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL 360
MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL
Sbjct: 301 MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL 360
Query: 361 KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE 420
KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE
Sbjct: 361 KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE 420
Query: 421 ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHATHS 470
ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHATHS
Sbjct: 421 ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHATHS 470
>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
Length = 599
Score = 932 bits (2408), Expect = 0.0
Identities = 466/466 (100%), Positives = 466/466 (100%)
Query: 1 MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL 60
MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL
Sbjct: 1 MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL 60
Query: 61 KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI 120
KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI
Sbjct: 61 KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI 120
Query: 121 QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR 180
QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR
Sbjct: 121 QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR 180
Query: 181 LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI 240
LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI
Sbjct: 181 LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI 240
Query: 241 VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE 300
VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE
Sbjct: 241 VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE 300
Query: 301 MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL 360
MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL
Sbjct: 301 MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL 360
Query: 361 KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE 420
KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE
Sbjct: 361 KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE 420
Query: 421 ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYH 466
ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYH
Sbjct: 421 ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYH 466
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 932 bits (2408), Expect = 0.0
Identities = 466/466 (100%), Positives = 466/466 (100%)
Query: 1 MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL 60
MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL
Sbjct: 1 MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL 60
Query: 61 KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI 120
KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI
Sbjct: 61 KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI 120
Query: 121 QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR 180
QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR
Sbjct: 121 QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR 180
Query: 181 LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI 240
LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI
Sbjct: 181 LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI 240
Query: 241 VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE 300
VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE
Sbjct: 241 VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE 300
Query: 301 MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL 360
MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL
Sbjct: 301 MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL 360
Query: 361 KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE 420
KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE
Sbjct: 361 KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE 420
Query: 421 ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYH 466
ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYH
Sbjct: 421 ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYH 466
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 229 bits (584), Expect = 4e-60
Identities = 114/265 (43%), Positives = 173/265 (65%), Gaps = 7/265 (2%)
Query: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
Y + +G GS+G V LV K +R + V+K++++ + E A EAQLLS+L H
Sbjct: 6 YCYLRVVGKGSYGEVTLV---KHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKH 62
Query: 89 PAIVKFHASFVEQDNFC-IITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
P IV + S+ D I+ +CEG DL K++E K G++ PENQ++EWF+Q+ + +
Sbjct: 63 PNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQK--GQLLPENQVVEWFVQIAMALQ 120
Query: 148 YMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKH 206
Y+HE+ ILHRDLK++NVFL + N++K+GD G++R+L CD+A+TL GTP+YMSPE +
Sbjct: 121 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN 180
Query: 207 QGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES 266
+ Y+ KSD+W+L C +YEM + HAF + S+V +I+EG P +P Y EL ++ +
Sbjct: 181 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT 240
Query: 267 MLNKNPSLRPSAIEILKIPYLDEQL 291
ML+K P RPS IL+ PY+ Q+
Sbjct: 241 MLSKRPEERPSVRSILRQPYIKRQI 265
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 220 bits (561), Expect = 2e-57
Identities = 128/367 (34%), Positives = 210/367 (57%), Gaps = 10/367 (2%)
Query: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
Y++ + +G GSFG LV + + ++ +KEI + + N T + EA LL+K+ H
Sbjct: 4 YMVLRMIGEGSFGRALLVQHESSN---QMFAMKEIRLPKSFSN-TQNSRKEAVLLAKMKH 59
Query: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
P IV F SF + + I+ EYC+G DL KI++ K GK+FPE+ I+ WF Q+ LGV++
Sbjct: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQK--GKLFPEDMILNWFTQMCLGVNH 117
Query: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
+H++R+LHRD+KSKN+FL +N +K+GDFG +RLL A T GTP+Y+ PE ++
Sbjct: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
Query: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESM 267
Y+ KSDIWSL CILYE+C + H F +++ +++LK+ +G LP Y EL +++ M
Sbjct: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237
Query: 268 LNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHL 327
+NPS RPSA +L + +Q + M ++ L+ K + H N +K+ +
Sbjct: 238 FKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKH--NTPRKKTNP 295
Query: 328 QTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQLS 387
+R + T +E + RK D ++ + +VE ++ + +S + ++ S
Sbjct: 296 SRIRIALGNEASTVQEEEQDRKGSHTDLESIN-ENLVESALRRVNREEKGNKSVHLRKAS 354
Query: 388 VDVLHEK 394
LH +
Sbjct: 355 SPNLHRR 361
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 220 bits (561), Expect = 2e-57
Identities = 128/367 (34%), Positives = 210/367 (57%), Gaps = 10/367 (2%)
Query: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
Y++ + +G GSFG LV + + ++ +KEI + + N T + EA LL+K+ H
Sbjct: 4 YMVLRMIGEGSFGRALLVQHESSN---QMFAMKEIRLPKSFSN-TQNSRKEAVLLAKMKH 59
Query: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
P IV F SF + + I+ EYC+G DL KI++ K GK+FPE+ I+ WF Q+ LGV++
Sbjct: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQK--GKLFPEDMILNWFTQMCLGVNH 117
Query: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
+H++R+LHRD+KSKN+FL +N +K+GDFG +RLL A T GTP+Y+ PE ++
Sbjct: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
Query: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESM 267
Y+ KSDIWSL CILYE+C + H F +++ +++LK+ +G LP Y EL +++ M
Sbjct: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237
Query: 268 LNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHL 327
+NPS RPSA +L + +Q + M ++ L+ K + H N +K+ +
Sbjct: 238 FKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKH--NTPRKKTNP 295
Query: 328 QTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQLS 387
+R + T +E + RK D ++ + +VE ++ + +S + ++ S
Sbjct: 296 SRIRIALGNEASTVQEEEQDRKGSHTDLESIN-ENLVESALRRVNREEKGNKSVHLRKAS 354
Query: 388 VDVLHEK 394
LH +
Sbjct: 355 SPNLHRR 361
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 220 bits (561), Expect = 2e-57
Identities = 104/269 (38%), Positives = 176/269 (65%), Gaps = 6/269 (2%)
Query: 28 RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87
+YV QK+G GSFG LV K + G + V+KEI++ ++ E ++ E +L+ +
Sbjct: 3 KYVRLQKIGEGSFGKAILV--KSTEDGRQY-VIKEINISRMSSKEREESRREVAVLANMK 59
Query: 88 HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
HP IV++ SF E + I+ +YCEG DL +I K G +F E+QI++WF+Q+ L +
Sbjct: 60 HPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQK--GVLFQEDQILDWFVQICLALK 117
Query: 148 YMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKH 206
++H+R+ILHRD+KS+N+FL K+ +++GDFG++R+L + +LA T GTP+Y+SPE ++
Sbjct: 118 HVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICEN 177
Query: 207 QGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES 266
+ Y+ KSDIW+L C+LYE+C + HAF + ++VLKI+ G P + Y +L +++
Sbjct: 178 KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQ 237
Query: 267 MLNKNPSLRPSAIEILKIPYLDEQLQNLM 295
+ +NP RPS IL+ ++ ++++ +
Sbjct: 238 LFKRNPRDRPSVNSILEKGFIAKRIEKFL 266
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 218 bits (554), Expect = 1e-56
Identities = 114/283 (40%), Positives = 175/283 (61%), Gaps = 12/283 (4%)
Query: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
Y++ + +G GSFG LV + + ++ +KEI + + N T + EA LL+K+ H
Sbjct: 4 YMVLRMIGEGSFGRALLVQHESSN---QMFAMKEIRLPKSFSN-TQNSRKEAVLLAKMKH 59
Query: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
P IV F SF + + I+ EYC+G DL KI++ K GK+FPE+ I+ WF Q+ LGV++
Sbjct: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQK--GKLFPEDMILNWFTQMCLGVNH 117
Query: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
+H++R+LHRD+KSKN+FL +N +K+GDFG +RLL A T GTP+Y+ PE ++
Sbjct: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177
Query: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESM 267
Y+ KSDIWSL CILYE+C + H F +++ +++LK+ +G LP Y EL +++ M
Sbjct: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237
Query: 268 LNKNPSLRPSAIEILKIPYLDEQLQ-----NLMCRYSEMTLED 305
+NPS RPSA +L + +Q ++ Y E LE+
Sbjct: 238 FKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEE 280
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 214 bits (544), Expect = 2e-55
Identities = 109/273 (39%), Positives = 171/273 (62%), Gaps = 11/273 (4%)
Query: 28 RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87
+Y + + +G G+FG YL K K + V+KEI+ ++ E + E LL K+
Sbjct: 3 KYDVIKAIGQGAFGKAYLA---KGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMK 59
Query: 88 HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
HP IV F SF E I+ EYC+G DL +I +Q G +F E+QI+ WF+Q+ LG+
Sbjct: 60 HPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRIN--RQRGVLFSEDQILGWFVQISLGLK 117
Query: 148 YMHERRILHRDLKSKNVFLKNN--LLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
++H+R+ILHRD+K++N+FL N + K+GDFG++R+L S +LA T GTP+Y+SPE +
Sbjct: 118 HIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQ 177
Query: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
++ Y+ K+DIWSL C+LYE+C + H F G+N +VLKI + + + +EL++++
Sbjct: 178 NKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLIS 237
Query: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRY 298
+ +P RPS ILK P+ L+NL+ +Y
Sbjct: 238 QLFQVSPRDRPSINSILKRPF----LENLIPKY 266
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 181 bits (460), Expect = 1e-45
Identities = 134/419 (31%), Positives = 203/419 (48%), Gaps = 36/419 (8%)
Query: 26 ARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSK 85
A Y + +G+GS+G + + K ++ V KE+ G + E E LL +
Sbjct: 5 AEDYEVLYTIGTGSYGRCQKI---RRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRE 61
Query: 86 LDHPAIVKFHASFVEQDN--FCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLL 143
L HP IV+++ +++ N I+ EYCEG DL I + + + E ++ QL
Sbjct: 62 LKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121
Query: 144 LGVDYMHERR-----ILHRDLKSKNVFL--KNNLLKIGDFGVSRLLMGSCDLATTLTGTP 196
L + H R +LHRDLK NVFL K N+ K+GDFG++R+L A T GTP
Sbjct: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV-KLGDFGLARILNHDTSFAKTFVGTP 180
Query: 197 HYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERY 256
+YMSPE + Y+ KSDIWSL C+LYE+C + F + + KI EG +P RY
Sbjct: 181 YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY 240
Query: 257 PKELNAIMESMLNKNPSLRPSAIEILKIPYL-----DEQLQNLMCRYSEMTLEDKNLDCQ 311
ELN I+ MLN RPS EIL+ P + DEQ +NL R ++ +K+ D
Sbjct: 241 SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS 300
Query: 312 KEAAHI-INAMQKRIHLQTLRALSE-----VQKMTPRERMRLRKLQAADEKARKLKKIVE 365
+ + + +Q + + L+A E Q++ RER+ KL A+ + + E
Sbjct: 301 PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE 360
Query: 366 EKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKE-----EQPEGRLSCSPQDED 419
K+ + + L L V+ +K H G E KE E E +L+ + +D
Sbjct: 361 RKFLSLASNPELL------NLPSSVIKKKVHFSG-ESKENIMRSENSESQLTSKSKCKD 412
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 176 bits (446), Expect = 4e-44
Identities = 97/269 (36%), Positives = 158/269 (58%), Gaps = 8/269 (2%)
Query: 28 RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87
+Y + +G G+FG V+L K ++L ++K+I V ++ E A E Q+L L+
Sbjct: 3 KYERIRVVGRGAFGIVHLCL---RKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLN 59
Query: 88 HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
HP +++++ +F+E I EY G L + IQ K+ + E I+ +F+Q+LL +
Sbjct: 60 HPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQ--KRCNSLLEEETILHFFVQILLALH 117
Query: 148 YMHERRILHRDLKSKNVFLKNN--LLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
++H ILHRDLK++N+ L + ++KIGDFG+S++L S A T+ GTP Y+SPE +
Sbjct: 118 HVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKIL-SSKSKAYTVVGTPCYISPELCE 176
Query: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
+ Y+ KSDIW+L C+LYE+ + AF +N ++VLKI+ G + +RY EL ++
Sbjct: 177 GKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVL 236
Query: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNL 294
S+L+ P+ RP I+ P L NL
Sbjct: 237 SLLSLEPAQRPPLSHIMAQPLCIRALLNL 265
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 171 bits (432), Expect = 2e-42
Identities = 90/260 (34%), Positives = 148/260 (56%), Gaps = 10/260 (3%)
Query: 31 LQQKLGSGSFGTVYLVSDKKAKRGEELKV-LKEISVGEL-NPNETVQANLEAQLLSKLDH 88
+++K+G G F VY + A + + V LK++ + +L + E LL +L+H
Sbjct: 36 IEKKIGRGQFSEVY----RAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNH 91
Query: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
P ++K++ASF+E + I+ E + DL I+ +K+ ++ PE + ++F+QL +++
Sbjct: 92 PNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEH 151
Query: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
MH RR++HRD+K NVF+ ++K+GD G+ R A +L GTP+YMSPE +
Sbjct: 152 MHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHEN 211
Query: 208 GYDTKSDIWSLACILYEMCCMNHAFAGS--NFLSIVLKIVEGDTPSLP-ERYPKELNAIM 264
GY+ KSDIWSL C+LYEM + F G N S+ KI + D P LP + Y +EL ++
Sbjct: 212 GYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLV 271
Query: 265 ESMLNKNPSLRPSAIEILKI 284
+N +P RP + +
Sbjct: 272 NMCINPDPEKRPDVTYVYDV 291
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 167 bits (423), Expect = 2e-41
Identities = 95/269 (35%), Positives = 150/269 (55%), Gaps = 18/269 (6%)
Query: 20 YPKTLIAR----RYVLQQKLGSGSFGTVYLVS---DKKAKRGEELKVLKEISVGELNPNE 72
+P TL R + +++K+G G F VY + D+K LK++ + E+ +
Sbjct: 66 HPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTV------ALKKVQIFEMMDAK 119
Query: 73 TVQANL-EAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFP 131
Q + E LL +L+HP I+K+ SF+E + I+ E + DL I+ +K+ ++ P
Sbjct: 120 ARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIP 179
Query: 132 ENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLAT 190
E + ++F+QL V++MH RR++HRD+K NVF+ ++K+GD G+ R A
Sbjct: 180 ERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAH 239
Query: 191 TLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGS--NFLSIVLKIVEGD 248
+L GTP+YMSPE + GY+ KSDIWSL C+LYEM + F G N S+ KI + D
Sbjct: 240 SLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCD 299
Query: 249 TPSLP-ERYPKELNAIMESMLNKNPSLRP 276
P LP E Y ++L ++ + +P RP
Sbjct: 300 YPPLPGEHYSEKLRELVSMCICPDPHQRP 328
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 167 bits (423), Expect = 2e-41
Identities = 95/269 (35%), Positives = 150/269 (55%), Gaps = 18/269 (6%)
Query: 20 YPKTLIAR----RYVLQQKLGSGSFGTVYLVS---DKKAKRGEELKVLKEISVGELNPNE 72
+P TL R + +++K+G G F VY + D+K LK++ + E+ +
Sbjct: 32 HPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTV------ALKKVQIFEMMDAK 85
Query: 73 TVQANL-EAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFP 131
Q + E LL +L+HP I+K+ SF+E + I+ E + DL I+ +K+ ++ P
Sbjct: 86 ARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIP 145
Query: 132 ENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLAT 190
E + ++F+QL V++MH RR++HRD+K NVF+ ++K+GD G+ R A
Sbjct: 146 ERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAH 205
Query: 191 TLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGS--NFLSIVLKIVEGD 248
+L GTP+YMSPE + GY+ KSDIWSL C+LYEM + F G N S+ KI + D
Sbjct: 206 SLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCD 265
Query: 249 TPSLP-ERYPKELNAIMESMLNKNPSLRP 276
P LP E Y ++L ++ + +P RP
Sbjct: 266 YPPLPGEHYSEKLRELVSMCICPDPHQRP 294
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 163 bits (412), Expect = 4e-40
Identities = 92/269 (34%), Positives = 155/269 (57%), Gaps = 8/269 (2%)
Query: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
Y+ + LG G+FG L + + L V KE+ + L+ E A E +L+ L H
Sbjct: 52 YIPIRVLGRGAFGEATLY---RRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQH 108
Query: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
I+ ++ F++ I EYC G +L DKI +Q K+F E ++ + Q++ V
Sbjct: 109 DNIIAYYNHFMDNTTLLIELEYCNGGNLYDKI--LRQKDKLFEEEMVVWYLFQIVSAVSC 166
Query: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
+H+ ILHRD+K+ N+FL K NL+K+GD+G+++ L +A TL GTP+YMSPE +
Sbjct: 167 IHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGV 226
Query: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPE--RYPKELNAIME 265
Y+ KSDIW++ C+++E+ + F +N L++ +KIV+G + +Y EL ++
Sbjct: 227 KYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVH 286
Query: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNL 294
S L+++P RP+A E+L P L ++ + +
Sbjct: 287 SCLDQDPEQRPTADELLDRPLLRKRRREM 315
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 142 bits (359), Expect = 5e-34
Identities = 92/308 (29%), Positives = 153/308 (49%), Gaps = 20/308 (6%)
Query: 13 GSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNE 72
GST + P+ L + +K+G GSFG V+ D + ++ +K++ ++ E +E
Sbjct: 24 GSTNLKADPEELFTKL----EKIGKGSFGEVFKGIDNRTQKVVAIKII-DLEEAE---DE 75
Query: 73 TVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPE 132
E +LS+ D P + K++ S+++ II EY G D ++ E
Sbjct: 76 IEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGP-----LDE 130
Query: 133 NQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATT 191
QI ++L G+DY+H + +HRD+K+ NV L ++ +K+ DFGV+ L + T
Sbjct: 131 TQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNT 190
Query: 192 LTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPS 251
GTP +M+PE +K YD+K+DIWSL E+ + + + ++ I + + P+
Sbjct: 191 FVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPT 250
Query: 252 LPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYL------DEQLQNLMCRYSEMTLED 305
L Y K L +E+ LNK PS RP+A E+LK ++ L L+ RY E
Sbjct: 251 LEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQ 310
Query: 306 KNLDCQKE 313
+ D E
Sbjct: 311 SHDDSSSE 318
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 139 bits (351), Expect = 4e-33
Identities = 87/288 (30%), Positives = 145/288 (50%), Gaps = 16/288 (5%)
Query: 33 QKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIV 92
+K+G GSFG V+ D + ++ +K++ ++ E +E E +LS+ D P +
Sbjct: 28 EKIGKGSFGEVFKGIDNRTQKVVAIKII-DLEEAE---DEIEDIQQEITVLSQCDSPYVT 83
Query: 93 KFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHER 152
K++ S+++ II EY G D ++ E QI ++L G+DY+H
Sbjct: 84 KYYGSYLKDTKLWIIMEYLGGGSALDLLEPGP-----LDETQIATILREILKGLDYLHSE 138
Query: 153 RILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDT 211
+ +HRD+K+ NV L ++ +K+ DFGV+ L + T GTP +M+PE +K YD+
Sbjct: 139 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 198
Query: 212 KSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKN 271
K+DIWSL E+ + + + ++ I + + P+L Y K L +E+ LNK
Sbjct: 199 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKE 258
Query: 272 PSLRPSAIEILKIPYL------DEQLQNLMCRYSEMTLEDKNLDCQKE 313
PS RP+A E+LK ++ L L+ RY E + D E
Sbjct: 259 PSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSE 306
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 137 bits (344), Expect = 3e-32
Identities = 80/258 (31%), Positives = 135/258 (52%), Gaps = 8/258 (3%)
Query: 27 RRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL 86
+RY + LG G F Y ++D + K++ V + + E + +E + L
Sbjct: 80 KRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRI--L 137
Query: 87 DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGV 146
H +V+F+ F +++N I+ EYC R + ++ A K+ E ++ + Q++ G+
Sbjct: 138 HHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILK----ARKVLTEPEVRYYLRQIVSGL 193
Query: 147 DYMHERRILHRDLKSKNVFLKNNL-LKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
Y+HE+ ILHRDLK N F+ + LK+GDFG++ L T+ GTP+Y+SPE L
Sbjct: 194 KYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLN 253
Query: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
QG+ +SDIW+L C++Y M F +N L + + ++P ++
Sbjct: 254 KQGHGCESDIWALGCVMYTMLLGRPPFETTN-LKETYRCIREARYTMPSSLLAPAKHLIA 312
Query: 266 SMLNKNPSLRPSAIEILK 283
SML+KNP RPS +I++
Sbjct: 313 SMLSKNPEDRPSLDDIIR 330
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 134 bits (338), Expect = 1e-31
Identities = 111/412 (26%), Positives = 196/412 (47%), Gaps = 34/412 (8%)
Query: 34 KLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVK 93
+LG G+FG VY +K+ KV+ S EL +E +L+ DHP IVK
Sbjct: 39 ELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELE-----DYMVEIDILASCDHPNIVK 93
Query: 94 FHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERR 153
+F ++N I+ E+C G +D + E ++ E+QI Q L ++Y+H+ +
Sbjct: 94 LLDAFYYENNLWILIEFCAGGAVDAVMLELERP---LTESQIQVVCKQTLDALNYLHDNK 150
Query: 154 ILHRDLKSKNV-FLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEAL-----KHQ 207
I+HRDLK+ N+ F + +K+ DFGVS + + GTP++M+PE + K +
Sbjct: 151 IIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDR 210
Query: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSL--PERYPKELNAIME 265
YD K+D+WSL L EM + N + ++LKI + + P+L P R+ ++
Sbjct: 211 PYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLK 270
Query: 266 SMLNKNPSLRPSAIEILKIPY--------LDEQLQNLMCRYSEMTLEDKNLDCQKEAAHI 317
L KN R + ++L+ P+ + E + +E + K D ++E +
Sbjct: 271 KCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETENS 330
Query: 318 IN-AMQKRIHLQTLRALSEVQKMTPRE---RMRLRKLQAADEKARKLKKIVEEK--YEEN 371
+ KR A SE K++ K + ++ + + KI+ EK +E
Sbjct: 331 LPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEP 390
Query: 372 SKRMQELRSR--NFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEE 421
K ++++ + Q ++ LH++T + E+E++P +L P ED+E
Sbjct: 391 EKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRP--KLENLPDTEDQE 440
Score = 29.3 bits (64), Expect = 8.1
Identities = 53/246 (21%), Positives = 93/246 (37%), Gaps = 53/246 (21%)
Query: 245 VEGDTPSLPERYPKELNAIMESMLNKNPSL---RPSAIEILKIPYLDEQLQNLMCRYSEM 301
++G + ++ EL I LN L R +AI L+ +L E+ Q L +
Sbjct: 971 LDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLL-----KQ 1025
Query: 302 TLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKAR--- 358
L+D+ + + +++ R + E++ +ER RL K+Q ++ K R
Sbjct: 1026 QLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAM 1085
Query: 359 ------------------KLKKIV--EEKYEENSKRMQ---------------ELRSRNF 383
K+K+ EEK ++N + Q E R
Sbjct: 1086 FKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVREL 1145
Query: 384 QQLSVD-----VLHEKTHLKGMEEK--EEQPEGRLSCSPQDEDEERWQGREEESDEPTLE 436
QL + V HE LK ++E+ +E E R P+ + E R+ + E +
Sbjct: 1146 HQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFK 1205
Query: 437 NLPESQ 442
ES+
Sbjct: 1206 MTGESE 1211
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 134 bits (336), Expect = 2e-31
Identities = 89/281 (31%), Positives = 146/281 (51%), Gaps = 18/281 (6%)
Query: 34 KLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVK 93
+LG G+FG VY +K+ KV++ S EL +E ++L+ DHP IVK
Sbjct: 41 ELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELE-----DYIVEIEILATCDHPYIVK 95
Query: 94 FHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERR 153
++ I+ E+C G +D + E + G P+ Q++ Q+L ++++H +R
Sbjct: 96 LLGAYYHDGKLWIMIEFCPGGAVDAIMLELDR-GLTEPQIQVV--CRQMLEALNFLHSKR 152
Query: 154 ILHRDLKSKNVFLK-NNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEA-----LKHQ 207
I+HRDLK+ NV + +++ DFGVS + + + GTP++M+PE +K
Sbjct: 153 IIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDT 212
Query: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSL--PERYPKELNAIME 265
YD K+DIWSL L EM + N + ++LKI + D P+L P ++ E ++
Sbjct: 213 PYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLK 272
Query: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDK 306
L+KNP RPSA ++L+ P++ N R E+ E K
Sbjct: 273 IALDKNPETRPSAAQLLEHPFVSSITSNKALR--ELVAEAK 311
Score = 41.6 bits (96), Expect = 0.002
Identities = 38/168 (22%), Positives = 77/168 (45%), Gaps = 12/168 (7%)
Query: 238 LSIVLKIVEGDTPSLPERYPKE-LNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMC 296
L ++ K V+ + LP + KE + ME K ++L ++ +Q ++L
Sbjct: 657 LKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKK--------QLLDRDFVAKQKEDLEL 708
Query: 297 RYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK 356
+T +++ C KE ++ ++ + AL E+++ +ER +L K Q D+
Sbjct: 709 AMKRLTTDNRREICDKERECLMK--KQELLRDREAALWEMEEHQLQERHQLVKQQLKDQY 766
Query: 357 ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKE 404
+ +++ K+E+ ++MQ R +QL V EK L ++ E
Sbjct: 767 FLQRHELLR-KHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSE 813
Score = 33.5 bits (75), Expect = 0.43
Identities = 35/166 (21%), Positives = 73/166 (43%), Gaps = 32/166 (19%)
Query: 289 EQLQNLMCRYSEMTLEDKNLDCQKEAAHI-----------INAMQKRIHLQTLRALSEVQ 337
E+ + M RY++ +E + Q+E A + + +K +H+ + +E
Sbjct: 778 EKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAE-- 835
Query: 338 KMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKR---------MQELRSRNFQQLSV 388
+R ++++ +EK +K +++ +++ EN R M EL+ ++ +
Sbjct: 836 -----QREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHL 890
Query: 389 DVLHEKTHLKGMEEKEEQ--PEGRLSCSPQD---EDEERWQGREEE 429
V HE LK ++E Q E R P+ E++ + RE+E
Sbjct: 891 LVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQE 936
>gi|21359873 polo-like kinase 1 [Homo sapiens]
Length = 603
Score = 132 bits (333), Expect = 5e-31
Identities = 79/257 (30%), Positives = 134/257 (52%), Gaps = 8/257 (3%)
Query: 27 RRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL 86
RRYV + LG G F + +SD K K++ + + L P++ + ++E + L
Sbjct: 51 RRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLL--LKPHQREKMSMEISIHRSL 108
Query: 87 DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGV 146
H +V FH F + D ++ E C R L E + K E + + Q++LG
Sbjct: 109 AHQHVVGFHGFFEDNDFVFVVLELCRRRSL----LELHKRRKALTEPEARYYLRQIVLGC 164
Query: 147 DYMHERRILHRDLKSKNVFLKNNL-LKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
Y+H R++HRDLK N+FL +L +KIGDFG++ + + TL GTP+Y++PE L
Sbjct: 165 QYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLS 224
Query: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
+G+ + D+WS+ CI+Y + F S L+I + + S+P+ ++++
Sbjct: 225 KKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEY-SIPKHINPVAASLIQ 283
Query: 266 SMLNKNPSLRPSAIEIL 282
ML +P+ RP+ E+L
Sbjct: 284 KMLQTDPTARPTINELL 300
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 130 bits (326), Expect = 3e-30
Identities = 99/307 (32%), Positives = 161/307 (52%), Gaps = 32/307 (10%)
Query: 18 STYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL--KEISVG---ELNPNE 72
S YPK L Y++ + LGSG+ G V L ++K + +K++ ++ ++G E +P
Sbjct: 253 SVYPKAL-RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPAL 311
Query: 73 TVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPE 132
V+ +E +L KL+HP I+K +F + +++ I+ E EG +L DK+ K+ E
Sbjct: 312 NVETEIE--ILKKLNHPCIIKIK-NFFDAEDYYIVLELMEGGELFDKVVGNKR----LKE 364
Query: 133 NQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNN----LLKIGDFGVSRLLMGSCDL 188
+F Q+LL V Y+HE I+HRDLK +NV L + L+KI DFG S++L G L
Sbjct: 365 ATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL-GETSL 423
Query: 189 ATTLTGTPHYMSPEALKH---QGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLK-- 243
TL GTP Y++PE L GY+ D WSL IL+ +C + + + LK
Sbjct: 424 MRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILF-ICLSGYPPFSEHRTQVSLKDQ 482
Query: 244 IVEGDTPSLPE---RYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQ-----LQNLM 295
I G +PE ++ +++ +L +P R + E L+ P+L ++ Q+L+
Sbjct: 483 ITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLL 542
Query: 296 CRYSEMT 302
+E T
Sbjct: 543 SEENEST 549
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 130 bits (326), Expect = 3e-30
Identities = 99/307 (32%), Positives = 161/307 (52%), Gaps = 32/307 (10%)
Query: 18 STYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL--KEISVG---ELNPNE 72
S YPK L Y++ + LGSG+ G V L ++K + +K++ ++ ++G E +P
Sbjct: 210 SVYPKAL-RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPAL 268
Query: 73 TVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPE 132
V+ +E +L KL+HP I+K +F + +++ I+ E EG +L DK+ K+ E
Sbjct: 269 NVETEIE--ILKKLNHPCIIKIK-NFFDAEDYYIVLELMEGGELFDKVVGNKR----LKE 321
Query: 133 NQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNN----LLKIGDFGVSRLLMGSCDL 188
+F Q+LL V Y+HE I+HRDLK +NV L + L+KI DFG S++L G L
Sbjct: 322 ATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL-GETSL 380
Query: 189 ATTLTGTPHYMSPEALKH---QGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLK-- 243
TL GTP Y++PE L GY+ D WSL IL+ +C + + + LK
Sbjct: 381 MRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILF-ICLSGYPPFSEHRTQVSLKDQ 439
Query: 244 IVEGDTPSLPE---RYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQ-----LQNLM 295
I G +PE ++ +++ +L +P R + E L+ P+L ++ Q+L+
Sbjct: 440 ITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLL 499
Query: 296 CRYSEMT 302
+E T
Sbjct: 500 SEENEST 506
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 129 bits (325), Expect = 4e-30
Identities = 84/267 (31%), Positives = 142/267 (53%), Gaps = 22/267 (8%)
Query: 28 RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANL--EAQLLSK 85
+Y + + +G GSFG VY K +R +V+ + +L +E NL E +++
Sbjct: 3 KYHVLEMIGEGSFGRVY-----KGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRG 57
Query: 86 LDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLG 145
L HP IV SF ++T+Y EG + Q + GK+ PE+Q+ QL+
Sbjct: 58 LRHPNIVHMLDSFETDKEVVVVTDYAEG----ELFQILEDDGKL-PEDQVQAIAAQLVSA 112
Query: 146 VDYMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEAL 204
+ Y+H RILHRD+K +N+ L K +K+ DFG +R + + + T++ GTP YMSPE +
Sbjct: 113 LYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELV 172
Query: 205 KHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNA-- 262
+ + YD +D+WS+ CILYE+ F ++ +V I++ P R+P ++
Sbjct: 173 EERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKD-----PVRWPSTISPCF 227
Query: 263 --IMESMLNKNPSLRPSAIEILKIPYL 287
++ +L K+P R S ++L P++
Sbjct: 228 KNFLQGLLTKDPRQRLSWPDLLYHPFI 254
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 127 bits (319), Expect = 2e-29
Identities = 77/256 (30%), Positives = 137/256 (53%), Gaps = 10/256 (3%)
Query: 33 QKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIV 92
+++G GSFG V+ D + ++ +K++ ++ E +E E +LS+ D +
Sbjct: 28 ERIGKGSFGEVFKGIDNRTQQVVAIKII-DLEEAE---DEIEDIQQEITVLSQCDSSYVT 83
Query: 93 KFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHER 152
K++ S+++ II EY G D ++ AG F E QI ++L G+DY+H
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLLR----AGP-FDEFQIATMLKEILKGLDYLHSE 138
Query: 153 RILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDT 211
+ +HRD+K+ NV L + +K+ DFGV+ L + T GTP +M+PE ++ YD+
Sbjct: 139 KKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS 198
Query: 212 KSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKN 271
K+DIWSL E+ + + + ++ I + + P+L + K +++ LNK+
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKD 258
Query: 272 PSLRPSAIEILKIPYL 287
PS RP+A E+LK ++
Sbjct: 259 PSFRPTAKELLKHKFI 274
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 127 bits (319), Expect = 2e-29
Identities = 89/296 (30%), Positives = 142/296 (47%), Gaps = 25/296 (8%)
Query: 34 KLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVK 93
++G GSFG VY D K E+ +K I + E +E E +LS+ D P I +
Sbjct: 25 RIGKGSFGEVYKGIDNHTK---EVVAIKIIDLEEAE-DEIEDIQQEITVLSQCDSPYITR 80
Query: 94 FHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERR 153
+ S+++ II EY G D ++ E I ++L G+DY+H R
Sbjct: 81 YFGSYLKSTKLWIIMEYLGGGSALDLLKPGP-----LEETYIATILREILKGLDYLHSER 135
Query: 154 ILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTK 212
+HRD+K+ NV L + +K+ DFGV+ L + T GTP +M+PE +K YD K
Sbjct: 136 KIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFK 195
Query: 213 SDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNP 272
+DIWSL E+ + + + ++ I + P+L ++ K +E+ LNK+P
Sbjct: 196 ADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDP 255
Query: 273 SLRPSAIEILKIPYLDEQ------LQNLMCRY---------SEMTLEDKNLDCQKE 313
RP+A E+LK ++ L L+ RY E + ED ++D + E
Sbjct: 256 RFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAE 311
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 127 bits (318), Expect = 3e-29
Identities = 79/258 (30%), Positives = 131/258 (50%), Gaps = 8/258 (3%)
Query: 27 RRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL 86
R Y+ + LG G F Y +D + +KV+ + V + + E + +E L L
Sbjct: 60 RTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIE--LHRDL 117
Query: 87 DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGV 146
H IV+F F + DN I E C + L +A E ++ + Q+L G+
Sbjct: 118 QHRHIVRFSHHFEDADNIYIFLELCSRKSL----AHIWKARHTLLEPEVRYYLRQILSGL 173
Query: 147 DYMHERRILHRDLKSKNVFLKNNL-LKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
Y+H+R ILHRDLK N F+ N+ LK+GDFG++ L T+ GTP+Y++PE L
Sbjct: 174 KYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL 233
Query: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
QG+ ++D+WSL C++Y + C + F ++ L + ++ +LP ++
Sbjct: 234 RQGHGPEADVWSLGCVMYTLLCGSPPFETAD-LKETYRCIKQVHYTLPASLSLPARQLLA 292
Query: 266 SMLNKNPSLRPSAIEILK 283
++L +P RPS +IL+
Sbjct: 293 AILRASPRDRPSIDQILR 310
>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
sapiens]
Length = 619
Score = 123 bits (309), Expect = 3e-28
Identities = 87/263 (33%), Positives = 132/263 (50%), Gaps = 18/263 (6%)
Query: 31 LQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANL---EAQLLSKLD 87
L + LG G+FG VYL D G EL V K++ +P + + N E QLL L
Sbjct: 358 LGKLLGQGAFGRVYLCYD--VDTGRELAV-KQVQFDPDSPETSKEVNALECEIQLLKNLL 414
Query: 88 HPAIVKFHASF--VEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLG 145
H IV+++ ++ I EY G + D+++ Y EN ++ Q+L G
Sbjct: 415 HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGA----LTENVTRKYTRQILEG 470
Query: 146 VDYMHERRILHRDLKSKNVFLKNN-LLKIGDFGVSRLLMGSCDLAT---TLTGTPHYMSP 201
V Y+H I+HRD+K N+ + +K+GDFG S+ L C T ++TGTP++MSP
Sbjct: 471 VHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSP 530
Query: 202 EALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDT-PSLPERYPKEL 260
E + +GY K+DIWS+AC + EM +A ++ + KI T P LP
Sbjct: 531 EVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYT 590
Query: 261 NAIMESMLNKNPSLRPSAIEILK 283
++ + LRPSA E+L+
Sbjct: 591 RDFLKRIF-VEAKLRPSADELLR 612
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 123 bits (308), Expect = 4e-28
Identities = 82/265 (30%), Positives = 131/265 (49%), Gaps = 12/265 (4%)
Query: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
++L ++LGSG++ TVY KK R E+ +K ++ LN E ++L + H
Sbjct: 14 FILTERLGSGTYATVYKAYAKKDTR--EVVAIKCVAKKSLNKASVENLLTEIEILKGIRH 71
Query: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
P IV+ + DN +I E+C G DL + +I PE + QL + +
Sbjct: 72 PHIVQLKDFQWDSDNIYLIMEFCAGGDLS----RFIHTRRILPEKVARVFMQQLASALQF 127
Query: 149 MHERRILHRDLKSKNVFLKN---NLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
+HER I H DLK +N+ L + LK+ DFG ++ M D L G+P YM+PE +
Sbjct: 128 LHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQH-MSPWDEKHVLRGSPLYMAPEMVC 186
Query: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPER--YPKELNAI 263
+ YD + D+WS+ ILYE FA +F + KI LP R ++ +
Sbjct: 187 QRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDL 246
Query: 264 MESMLNKNPSLRPSAIEILKIPYLD 288
++ +L ++PS R S + P++D
Sbjct: 247 LQRLLERDPSRRISFQDFFAHPWVD 271
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 120 bits (302), Expect = 2e-27
Identities = 79/264 (29%), Positives = 130/264 (49%), Gaps = 15/264 (5%)
Query: 33 QKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQA-NLEAQLLSKLDHPAI 91
Q++G G+F + Y D +K + + E V+A E +++S L+HP I
Sbjct: 1247 QQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNI 1306
Query: 92 VKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHE 151
++ + E+ N+ + E+ G + + +Y F E+ +I + QLL G+ Y+HE
Sbjct: 1307 IRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGA----FKESVVINYTEQLLRGLSYLHE 1362
Query: 152 RRILHRDLKSKNVFLKNN--LLKIGDFGVSRLLM----GSCDLATTLTGTPHYMSPEALK 205
+I+HRD+K N+ + + L+I DFG + L G+ + L GT +M+PE L+
Sbjct: 1363 NQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLR 1422
Query: 206 HQGYDTKSDIWSLACILYEMCCMN---HAFAGSNFLSIVLKIVEGDT-PSLPERYPKELN 261
Q Y D+WS+ C + EM C +A SN L+++ KI T PS+P L
Sbjct: 1423 GQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLR 1482
Query: 262 AIMESMLNKNPSLRPSAIEILKIP 285
+ L P RP + E+LK P
Sbjct: 1483 DVALRCLELQPQDRPPSRELLKHP 1506
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,749,188
Number of Sequences: 37866
Number of extensions: 850436
Number of successful extensions: 9594
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 731
Number of HSP's successfully gapped in prelim test: 589
Number of HSP's that attempted gapping in prelim test: 5304
Number of HSP's gapped (non-prelim): 2660
length of query: 470
length of database: 18,247,518
effective HSP length: 106
effective length of query: 364
effective length of database: 14,233,722
effective search space: 5181074808
effective search space used: 5181074808
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.