BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|40806179 receptor interacting protein kinase 5 isoform 1 [Homo sapiens] (929 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|40806179 receptor interacting protein kinase 5 isoform 1 [Hom... 1882 0.0 gi|40806181 receptor interacting protein kinase 5 isoform 2 [Hom... 1763 0.0 gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 89 1e-17 gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 89 1e-17 gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 89 1e-17 gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 89 1e-17 gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 87 9e-17 gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 84 5e-16 gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 84 5e-16 gi|5453976 protein kinase C, theta [Homo sapiens] 84 8e-16 gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas... 83 1e-15 gi|223671888 interleukin-1 receptor-associated kinase 4 isoform ... 80 9e-15 gi|223671885 interleukin-1 receptor-associated kinase 4 isoform ... 80 9e-15 gi|223671883 interleukin-1 receptor-associated kinase 4 isoform ... 80 9e-15 gi|166795293 interleukin-1 receptor-associated kinase 4 isoform ... 80 9e-15 gi|166795295 interleukin-1 receptor-associated kinase 4 isoform ... 80 9e-15 gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 80 9e-15 gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 80 1e-14 gi|4826776 Janus kinase 2 [Homo sapiens] 79 1e-14 gi|47157325 protein kinase C, delta [Homo sapiens] 79 1e-14 gi|31377782 protein kinase C, delta [Homo sapiens] 79 1e-14 gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 79 3e-14 gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 79 3e-14 gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 79 3e-14 gi|148596974 TXK tyrosine kinase [Homo sapiens] 79 3e-14 gi|148746218 TAO kinase 3 [Homo sapiens] 78 3e-14 gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 77 6e-14 gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 77 6e-14 gi|102469034 janus kinase 1 [Homo sapiens] 77 6e-14 gi|187475373 c-src tyrosine kinase [Homo sapiens] 77 6e-14 >gi|40806179 receptor interacting protein kinase 5 isoform 1 [Homo sapiens] Length = 929 Score = 1882 bits (4875), Expect = 0.0 Identities = 929/929 (100%), Positives = 929/929 (100%) Query: 1 MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHN 60 MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHN Sbjct: 1 MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHN 60 Query: 61 HTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQD 120 HTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQD Sbjct: 61 HTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQD 120 Query: 121 CNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAH 180 CNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAH Sbjct: 121 CNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAH 180 Query: 181 QGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDL 240 QGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDL Sbjct: 181 QGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDL 240 Query: 241 VNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESER 300 VNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESER Sbjct: 241 VNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESER 300 Query: 301 SPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAK 360 SPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAK Sbjct: 301 SPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAK 360 Query: 361 ALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMI 420 ALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMI Sbjct: 361 ALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMI 420 Query: 421 VETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKL 480 VETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKL Sbjct: 421 VETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKL 480 Query: 481 ISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRM 540 ISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRM Sbjct: 481 ISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRM 540 Query: 541 LWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAF 600 LWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAF Sbjct: 541 LWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAF 600 Query: 601 AASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGR 660 AASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGR Sbjct: 601 AASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGR 660 Query: 661 GQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDY 720 GQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDY Sbjct: 661 GQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDY 720 Query: 721 NYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKL 780 NYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKL Sbjct: 721 NYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKL 780 Query: 781 KNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWY 840 KNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWY Sbjct: 781 KNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWY 840 Query: 841 ICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLG 900 ICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLG Sbjct: 841 ICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLG 900 Query: 901 IVQPMLQGIMNRLCKSNSEQPNRGLDDST 929 IVQPMLQGIMNRLCKSNSEQPNRGLDDST Sbjct: 901 IVQPMLQGIMNRLCKSNSEQPNRGLDDST 929 >gi|40806181 receptor interacting protein kinase 5 isoform 2 [Homo sapiens] Length = 884 Score = 1763 bits (4567), Expect = 0.0 Identities = 884/929 (95%), Positives = 884/929 (95%), Gaps = 45/929 (4%) Query: 1 MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHN 60 MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHN Sbjct: 1 MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHN 60 Query: 61 HTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQD 120 HTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQD Sbjct: 61 HTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQD 120 Query: 121 CNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAH 180 CNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAH Sbjct: 121 CNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAH 180 Query: 181 QGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDL 240 QGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDL Sbjct: 181 QGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDL 240 Query: 241 VNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESER 300 VNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESER Sbjct: 241 VNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESER 300 Query: 301 SPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAK 360 SPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAK Sbjct: 301 SPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAK 360 Query: 361 ALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMI 420 ALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMI Sbjct: 361 ALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMI 420 Query: 421 VETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKL 480 VETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKL Sbjct: 421 VETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKL 480 Query: 481 ISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRM 540 ISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRM Sbjct: 481 ISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRM 540 Query: 541 LWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAF 600 LWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAF Sbjct: 541 LWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAF 600 Query: 601 AASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGR 660 AASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGR Sbjct: 601 AASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGR 660 Query: 661 GQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDY 720 GQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDY Sbjct: 661 GQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDY 720 Query: 721 NYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKL 780 NYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKL Sbjct: 721 NYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKL 780 Query: 781 KNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWY 840 KNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT Sbjct: 781 KNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT------------------ 822 Query: 841 ICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLG 900 GARPERLPVFDEECWQLMEACWDGDPLKRPLLG Sbjct: 823 ---------------------------GARPERLPVFDEECWQLMEACWDGDPLKRPLLG 855 Query: 901 IVQPMLQGIMNRLCKSNSEQPNRGLDDST 929 IVQPMLQGIMNRLCKSNSEQPNRGLDDST Sbjct: 856 IVQPMLQGIMNRLCKSNSEQPNRGLDDST 884 >gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] Length = 694 Score = 89.4 bits (220), Expect = 1e-17 Identities = 86/284 (30%), Positives = 130/284 (45%), Gaps = 35/284 (12%) Query: 646 VLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKS---VVPPDEKHWNDLALEFHYMR 702 VL H LG+++GRG +G V+ + A+KS +PPD K E ++ Sbjct: 427 VLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKA--KFLQEARILK 484 Query: 703 SLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHR-DLYTGLK---AGLTLETRLQIA 758 H +V L G + ++ME + D T L+ A L ++T LQ+ Sbjct: 485 QY-SHPNIVRLIGVCTQKQ-------PIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMV 536 Query: 759 LDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEA----MMSGSIVGTPI 814 D G+ +L S+ +HRD+ +N L+ ++N KI+D G + EA SG + P+ Sbjct: 537 GDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPV 596 Query: 815 H-MAPE-LFTGKYDNSVDVYAFGILFWYICS-GSVKLPEAFERCASKDHLWNNVRRGAR- 870 APE L G+Y + DV++FGIL W S G+ P S V +G R Sbjct: 597 KWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPN-----LSNQQTREFVEKGGRL 651 Query: 871 --PERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNR 912 PE P + ++LME CW +P +RP + LQ I R Sbjct: 652 PCPELCP---DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKR 692 >gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] Length = 752 Score = 89.4 bits (220), Expect = 1e-17 Identities = 86/284 (30%), Positives = 130/284 (45%), Gaps = 35/284 (12%) Query: 646 VLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKS---VVPPDEKHWNDLALEFHYMR 702 VL H LG+++GRG +G V+ + A+KS +PPD K E ++ Sbjct: 485 VLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKA--KFLQEARILK 542 Query: 703 SLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHR-DLYTGLK---AGLTLETRLQIA 758 H +V L G + ++ME + D T L+ A L ++T LQ+ Sbjct: 543 QY-SHPNIVRLIGVCTQKQ-------PIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMV 594 Query: 759 LDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEA----MMSGSIVGTPI 814 D G+ +L S+ +HRD+ +N L+ ++N KI+D G + EA SG + P+ Sbjct: 595 GDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPV 654 Query: 815 H-MAPE-LFTGKYDNSVDVYAFGILFWYICS-GSVKLPEAFERCASKDHLWNNVRRGAR- 870 APE L G+Y + DV++FGIL W S G+ P S V +G R Sbjct: 655 KWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPN-----LSNQQTREFVEKGGRL 709 Query: 871 --PERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNR 912 PE P + ++LME CW +P +RP + LQ I R Sbjct: 710 PCPELCP---DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKR 750 >gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] Length = 764 Score = 89.4 bits (220), Expect = 1e-17 Identities = 86/284 (30%), Positives = 130/284 (45%), Gaps = 35/284 (12%) Query: 646 VLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKS---VVPPDEKHWNDLALEFHYMR 702 VL H LG+++GRG +G V+ + A+KS +PPD K E ++ Sbjct: 497 VLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKA--KFLQEARILK 554 Query: 703 SLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHR-DLYTGLK---AGLTLETRLQIA 758 H +V L G + ++ME + D T L+ A L ++T LQ+ Sbjct: 555 QY-SHPNIVRLIGVCTQKQ-------PIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMV 606 Query: 759 LDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEA----MMSGSIVGTPI 814 D G+ +L S+ +HRD+ +N L+ ++N KI+D G + EA SG + P+ Sbjct: 607 GDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPV 666 Query: 815 H-MAPE-LFTGKYDNSVDVYAFGILFWYICS-GSVKLPEAFERCASKDHLWNNVRRGAR- 870 APE L G+Y + DV++FGIL W S G+ P S V +G R Sbjct: 667 KWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPN-----LSNQQTREFVEKGGRL 721 Query: 871 --PERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNR 912 PE P + ++LME CW +P +RP + LQ I R Sbjct: 722 PCPELCP---DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKR 762 >gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] Length = 822 Score = 89.4 bits (220), Expect = 1e-17 Identities = 86/284 (30%), Positives = 130/284 (45%), Gaps = 35/284 (12%) Query: 646 VLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKS---VVPPDEKHWNDLALEFHYMR 702 VL H LG+++GRG +G V+ + A+KS +PPD K E ++ Sbjct: 555 VLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKA--KFLQEARILK 612 Query: 703 SLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHR-DLYTGLK---AGLTLETRLQIA 758 H +V L G + ++ME + D T L+ A L ++T LQ+ Sbjct: 613 QY-SHPNIVRLIGVCTQKQ-------PIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMV 664 Query: 759 LDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEA----MMSGSIVGTPI 814 D G+ +L S+ +HRD+ +N L+ ++N KI+D G + EA SG + P+ Sbjct: 665 GDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPV 724 Query: 815 H-MAPE-LFTGKYDNSVDVYAFGILFWYICS-GSVKLPEAFERCASKDHLWNNVRRGAR- 870 APE L G+Y + DV++FGIL W S G+ P S V +G R Sbjct: 725 KWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPN-----LSNQQTREFVEKGGRL 779 Query: 871 --PERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNR 912 PE P + ++LME CW +P +RP + LQ I R Sbjct: 780 PCPELCP---DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKR 820 >gi|18250298 src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites [Homo sapiens] Length = 488 Score = 86.7 bits (213), Expect = 9e-17 Identities = 79/268 (29%), Positives = 120/268 (44%), Gaps = 18/268 (6%) Query: 649 HRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHE 708 H + LG++LG G +G V+ W G P A+K + + K DLA E ++ L +HE Sbjct: 227 HSEFALGRKLGEGYFGEVWE-GLWLGSLPVAIKVIKSANMK-LTDLAKEIQTLKGL-RHE 283 Query: 709 RLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAG--LTLETRLQIALDVVEGIR 766 RL+ LH GG V +M + + + G G L L L A V EG+ Sbjct: 284 RLIRLHAVCS----GGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMS 339 Query: 767 FLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFC---KPEAMMSGSIVGTPIH-MAPELFT 822 +L Q +VHRD+ +NVL+D K+ D G K + S P+ APE Sbjct: 340 YLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAAN 399 Query: 823 GK-YDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEEC 881 + + DV++FG+L + + + P +E + + L + RG R R E Sbjct: 400 YRVFSQKSDVWSFGVLLHEVFTYG-QCP--YEGMTNHETL-QQIMRGYRLPRPAACPAEV 455 Query: 882 WQLMEACWDGDPLKRPLLGIVQPMLQGI 909 + LM CW P +RP ++ L I Sbjct: 456 YVLMLECWRSSPEERPSFATLREKLHAI 483 >gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] Length = 675 Score = 84.3 bits (207), Expect = 5e-16 Identities = 76/263 (28%), Positives = 124/263 (47%), Gaps = 27/263 (10%) Query: 656 QELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG 715 +ELG GQ+GVV L W G + A+K ++ ++ E M L H +LV +G Sbjct: 421 KELGSGQFGVVQL-GKWKGQYDVAVK-MIKEGSMSEDEFFQEAQTMMKL-SHPKLVKFYG 477 Query: 716 SVIDYNYGGGSSIAVLLIMERLHRD-LYTGLKA---GLTLETRLQIALDVVEGIRFLHSQ 771 V Y + ++ E + L L++ GL L++ DV EG+ FL S Sbjct: 478 -VCSKEY------PIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESH 530 Query: 772 GLVHRDIKLKNVLLDKQNRAKITDLGFCK---PEAMMSGSIVGTPIH-MAPELF-TGKYD 826 +HRD+ +N L+D+ K++D G + + +S P+ APE+F KY Sbjct: 531 QFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYS 590 Query: 827 NSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLME 886 + DV+AFGIL W + S + + ++ + V +G R R + + +Q+M Sbjct: 591 SKSDVWAFGILMWEVFSLGKQPYDLYD----NSQVVLKVSQGHRLYRPHLASDTIYQIMY 646 Query: 887 ACWDGDPLKRP----LLGIVQPM 905 +CW P KRP LL ++P+ Sbjct: 647 SCWHELPEKRPTFQQLLSSIEPL 669 >gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] Length = 675 Score = 84.3 bits (207), Expect = 5e-16 Identities = 76/263 (28%), Positives = 124/263 (47%), Gaps = 27/263 (10%) Query: 656 QELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG 715 +ELG GQ+GVV L W G + A+K ++ ++ E M L H +LV +G Sbjct: 421 KELGSGQFGVVQL-GKWKGQYDVAVK-MIKEGSMSEDEFFQEAQTMMKL-SHPKLVKFYG 477 Query: 716 SVIDYNYGGGSSIAVLLIMERLHRD-LYTGLKA---GLTLETRLQIALDVVEGIRFLHSQ 771 V Y + ++ E + L L++ GL L++ DV EG+ FL S Sbjct: 478 -VCSKEY------PIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESH 530 Query: 772 GLVHRDIKLKNVLLDKQNRAKITDLGFCK---PEAMMSGSIVGTPIH-MAPELF-TGKYD 826 +HRD+ +N L+D+ K++D G + + +S P+ APE+F KY Sbjct: 531 QFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYS 590 Query: 827 NSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLME 886 + DV+AFGIL W + S + + ++ + V +G R R + + +Q+M Sbjct: 591 SKSDVWAFGILMWEVFSLGKQPYDLYD----NSQVVLKVSQGHRLYRPHLASDTIYQIMY 646 Query: 887 ACWDGDPLKRP----LLGIVQPM 905 +CW P KRP LL ++P+ Sbjct: 647 SCWHELPEKRPTFQQLLSSIEPL 669 >gi|5453976 protein kinase C, theta [Homo sapiens] Length = 706 Score = 83.6 bits (205), Expect = 8e-16 Identities = 64/218 (29%), Positives = 107/218 (49%), Gaps = 35/218 (16%) Query: 643 LQDVLLHRKPKLGQELGRGQYGVVYLCD----NWGGHFPCALKSVVPPD--------EKH 690 ++D +LH+ LG+G +G V+L + N K VV D EK Sbjct: 377 IEDFILHKM------LGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKR 430 Query: 691 WNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLT 750 LA E ++ + + + V++Y GG ++ ++ H+ Sbjct: 431 VLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGD----LMYHIQSCHK---------FD 477 Query: 751 LETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAM---MSG 807 L A +++ G++FLHS+G+V+RD+KL N+LLDK KI D G CK + + Sbjct: 478 LSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTN 537 Query: 808 SIVGTPIHMAPELFTG-KYDNSVDVYAFGILFWYICSG 844 + GTP ++APE+ G KY++SVD ++FG+L + + G Sbjct: 538 TFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIG 575 >gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1 [Homo sapiens] Length = 671 Score = 82.8 bits (203), Expect = 1e-15 Identities = 73/269 (27%), Positives = 119/269 (44%), Gaps = 42/269 (15%) Query: 657 ELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGS 716 EL G +G V LC + P+ N+ LE M + +H R+V L G Sbjct: 22 ELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGV 81 Query: 717 VIDYNYGGGSSIAVLLIMERLHR-DLYTGLKAGLT--LETRLQIALDVVEGIRFLHSQGL 773 +I+ L+ME + + +L LKA ++ L + +I L+++EG+ +LH +G+ Sbjct: 82 IIEEG-------KYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGV 134 Query: 774 VHRDIKLKNVLLDKQNRAKITDLGFCK-------------------PEAMMSGSIVGTPI 814 +H+D+K +N+L+D KI DLG A +G GT Sbjct: 135 IHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNG---GTLY 191 Query: 815 HMAPELF---TGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARP 871 +MAPE K DVY+F ++ W I + E +E + L ++ G RP Sbjct: 192 YMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANK----EPYENAICEQQLIMCIKSGNRP 247 Query: 872 ERLPVFD---EECWQLMEACWDGDPLKRP 897 + + + E LM+ CW+ +P RP Sbjct: 248 DVDDITEYCPREIISLMKLCWEANPEARP 276 >gi|223671888 interleukin-1 receptor-associated kinase 4 isoform b [Homo sapiens] Length = 336 Score = 80.1 bits (196), Expect = 9e-15 Identities = 61/201 (30%), Positives = 95/201 (47%), Gaps = 17/201 (8%) Query: 655 GQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHY---MRSLPKHERLV 711 G ++G G +GVVY + + A+K + + +L +F + + +HE LV Sbjct: 65 GNKMGEGGFGVVY--KGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLV 122 Query: 712 DLHGSVIDYNYGGGSSIAVLLIMER---LHRDLYTGLKAGLTLETRLQIALDVVEGIRFL 768 +L G ++ G V + M L R L+ R +IA GI FL Sbjct: 123 ELLG----FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFL 178 Query: 769 HSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK-----PEAMMSGSIVGTPIHMAPELFTG 823 H +HRDIK N+LLD+ AKI+D G + + +M+ IVGT +MAPE G Sbjct: 179 HENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRG 238 Query: 824 KYDNSVDVYAFGILFWYICSG 844 + D+Y+FG++ I +G Sbjct: 239 EITPKSDIYSFGVVLLEIITG 259 >gi|223671885 interleukin-1 receptor-associated kinase 4 isoform b [Homo sapiens] Length = 336 Score = 80.1 bits (196), Expect = 9e-15 Identities = 61/201 (30%), Positives = 95/201 (47%), Gaps = 17/201 (8%) Query: 655 GQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHY---MRSLPKHERLV 711 G ++G G +GVVY + + A+K + + +L +F + + +HE LV Sbjct: 65 GNKMGEGGFGVVY--KGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLV 122 Query: 712 DLHGSVIDYNYGGGSSIAVLLIMER---LHRDLYTGLKAGLTLETRLQIALDVVEGIRFL 768 +L G ++ G V + M L R L+ R +IA GI FL Sbjct: 123 ELLG----FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFL 178 Query: 769 HSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK-----PEAMMSGSIVGTPIHMAPELFTG 823 H +HRDIK N+LLD+ AKI+D G + + +M+ IVGT +MAPE G Sbjct: 179 HENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRG 238 Query: 824 KYDNSVDVYAFGILFWYICSG 844 + D+Y+FG++ I +G Sbjct: 239 EITPKSDIYSFGVVLLEIITG 259 >gi|223671883 interleukin-1 receptor-associated kinase 4 isoform b [Homo sapiens] Length = 336 Score = 80.1 bits (196), Expect = 9e-15 Identities = 61/201 (30%), Positives = 95/201 (47%), Gaps = 17/201 (8%) Query: 655 GQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHY---MRSLPKHERLV 711 G ++G G +GVVY + + A+K + + +L +F + + +HE LV Sbjct: 65 GNKMGEGGFGVVY--KGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLV 122 Query: 712 DLHGSVIDYNYGGGSSIAVLLIMER---LHRDLYTGLKAGLTLETRLQIALDVVEGIRFL 768 +L G ++ G V + M L R L+ R +IA GI FL Sbjct: 123 ELLG----FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFL 178 Query: 769 HSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK-----PEAMMSGSIVGTPIHMAPELFTG 823 H +HRDIK N+LLD+ AKI+D G + + +M+ IVGT +MAPE G Sbjct: 179 HENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRG 238 Query: 824 KYDNSVDVYAFGILFWYICSG 844 + D+Y+FG++ I +G Sbjct: 239 EITPKSDIYSFGVVLLEIITG 259 >gi|166795293 interleukin-1 receptor-associated kinase 4 isoform a [Homo sapiens] Length = 460 Score = 80.1 bits (196), Expect = 9e-15 Identities = 61/201 (30%), Positives = 95/201 (47%), Gaps = 17/201 (8%) Query: 655 GQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHY---MRSLPKHERLV 711 G ++G G +GVVY + + A+K + + +L +F + + +HE LV Sbjct: 189 GNKMGEGGFGVVY--KGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLV 246 Query: 712 DLHGSVIDYNYGGGSSIAVLLIMER---LHRDLYTGLKAGLTLETRLQIALDVVEGIRFL 768 +L G ++ G V + M L R L+ R +IA GI FL Sbjct: 247 ELLG----FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFL 302 Query: 769 HSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK-----PEAMMSGSIVGTPIHMAPELFTG 823 H +HRDIK N+LLD+ AKI+D G + + +M+ IVGT +MAPE G Sbjct: 303 HENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRG 362 Query: 824 KYDNSVDVYAFGILFWYICSG 844 + D+Y+FG++ I +G Sbjct: 363 EITPKSDIYSFGVVLLEIITG 383 >gi|166795295 interleukin-1 receptor-associated kinase 4 isoform a [Homo sapiens] Length = 460 Score = 80.1 bits (196), Expect = 9e-15 Identities = 61/201 (30%), Positives = 95/201 (47%), Gaps = 17/201 (8%) Query: 655 GQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHY---MRSLPKHERLV 711 G ++G G +GVVY + + A+K + + +L +F + + +HE LV Sbjct: 189 GNKMGEGGFGVVY--KGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLV 246 Query: 712 DLHGSVIDYNYGGGSSIAVLLIMER---LHRDLYTGLKAGLTLETRLQIALDVVEGIRFL 768 +L G ++ G V + M L R L+ R +IA GI FL Sbjct: 247 ELLG----FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFL 302 Query: 769 HSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK-----PEAMMSGSIVGTPIHMAPELFTG 823 H +HRDIK N+LLD+ AKI+D G + + +M+ IVGT +MAPE G Sbjct: 303 HENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRG 362 Query: 824 KYDNSVDVYAFGILFWYICSG 844 + D+Y+FG++ I +G Sbjct: 363 EITPKSDIYSFGVVLLEIITG 383 >gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] Length = 620 Score = 80.1 bits (196), Expect = 9e-15 Identities = 71/248 (28%), Positives = 114/248 (45%), Gaps = 17/248 (6%) Query: 656 QELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG 715 QE+G GQ+G+V+L W A+K++ D E M L H +LV L+G Sbjct: 367 QEIGSGQFGLVHL-GYWLNKDKVAIKTIREGAMSE-EDFIEEAEVMMKL-SHPKLVQLYG 423 Query: 716 SVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGL-TLETRLQIALDVVEGIRFLHSQGLV 774 ++ V ME Y + GL ET L + LDV EG+ +L ++ Sbjct: 424 VCLEQ----APICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVI 479 Query: 775 HRDIKLKNVLLDKQNRAKITDLG---FCKPEAMMSGSIVGTPIHMA-PELFT-GKYDNSV 829 HRD+ +N L+ + K++D G F + S + P+ A PE+F+ +Y + Sbjct: 480 HRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKS 539 Query: 830 DVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACW 889 DV++FG+L W + S K+P +E S + ++ G R + + +Q+M CW Sbjct: 540 DVWSFGVLMWEVFSEG-KIP--YEN-RSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCW 595 Query: 890 DGDPLKRP 897 P RP Sbjct: 596 KERPEDRP 603 >gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] Length = 659 Score = 79.7 bits (195), Expect = 1e-14 Identities = 68/270 (25%), Positives = 119/270 (44%), Gaps = 33/270 (12%) Query: 656 QELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG 715 +ELG GQ+GVV W G + A+K ++ ++ E M +L HE+LV L+G Sbjct: 406 KELGTGQFGVVKY-GKWRGQYDVAIK-MIKEGSMSEDEFIEEAKVMMNL-SHEKLVQLYG 462 Query: 716 S---------VIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIR 766 + +Y G + + E HR + L++ DV E + Sbjct: 463 VCTKQRPIFIITEYMANG---CLLNYLREMRHR---------FQTQQLLEMCKDVCEAME 510 Query: 767 FLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK---PEAMMSGSIVGTPIHMAPE--LF 821 +L S+ +HRD+ +N L++ Q K++D G + + S P+ +P L Sbjct: 511 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLM 570 Query: 822 TGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEEC 881 K+ + D++AFG+L W I S E F + +H + +G R R + E+ Sbjct: 571 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEH----IAQGLRLYRPHLASEKV 626 Query: 882 WQLMEACWDGDPLKRPLLGIVQPMLQGIMN 911 + +M +CW +RP I+ + +M+ Sbjct: 627 YTIMYSCWHEKADERPTFKILLSNILDVMD 656 >gi|4826776 Janus kinase 2 [Homo sapiens] Length = 1132 Score = 79.3 bits (194), Expect = 1e-14 Identities = 80/277 (28%), Positives = 124/277 (44%), Gaps = 38/277 (13%) Query: 650 RKPKLGQELGRGQYGVVYLC------DNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRS 703 R K Q+LG+G +G V +C DN G A+K + E+H D E ++S Sbjct: 847 RHLKFLQQLGKGNFGSVEMCRYDPLQDNTGE--VVAVKKLQHSTEEHLRDFEREIEILKS 904 Query: 704 LPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLH----RDLYTGLKAGLTLETRLQIAL 759 L +H+ +V G + Y+ G + + LIME L RD K + LQ Sbjct: 905 L-QHDNIVKYKG--VCYSAGRRN---LKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTS 958 Query: 760 DVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK-----PEAMMSGSIVGTPI 814 + +G+ +L ++ +HRD+ +N+L++ +NR KI D G K E +PI Sbjct: 959 QICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPI 1018 Query: 815 H-MAPELFT-GKYDNSVDVYAFGI----LFWYICSGSVKLPEAFERCASKD--------H 860 APE T K+ + DV++FG+ LF YI S P F R D H Sbjct: 1019 FWYAPESLTESKFSVASDVWSFGVVLYELFTYI-EKSKSPPAEFMRMIGNDKQGQMIVFH 1077 Query: 861 LWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRP 897 L ++ R R +E + +M CW+ + +RP Sbjct: 1078 LIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRP 1114 Score = 38.1 bits (87), Expect = 0.038 Identities = 44/186 (23%), Positives = 75/186 (40%), Gaps = 30/186 (16%) Query: 680 LKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYG----GGSSIAVLLIME 735 L V+ +++++ E M S H+ LV NYG G +I V ++ Sbjct: 579 LLKVLDKAHRNYSESFFEAASMMSKLSHKHLV--------LNYGVCVCGDENILVQEFVK 630 Query: 736 RLHRDLYTGL-KAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKIT 794 D Y K + + +L++A + + FL L+H ++ KN+LL ++ K Sbjct: 631 FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTG 690 Query: 795 DLGFCK-----------PEAMMSGSIVGTPIHMAPELFTG--KYDNSVDVYAFGILFWYI 841 + F K P+ ++ I P PE + + D ++FG W I Sbjct: 691 NPPFIKLSDPGISITVLPKDILQERIPWVP----PECIENPKNLNLATDKWSFGTTLWEI 746 Query: 842 CSGSVK 847 CSG K Sbjct: 747 CSGGDK 752 >gi|47157325 protein kinase C, delta [Homo sapiens] Length = 676 Score = 79.3 bits (194), Expect = 1e-14 Identities = 47/143 (32%), Positives = 78/143 (54%), Gaps = 10/143 (6%) Query: 758 ALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAM---MSGSIVGTPI 814 A +++ G++FLHS+G+++RD+KL NVLLD+ KI D G CK + + GTP Sbjct: 454 AAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPD 513 Query: 815 HMAPELFTG-KYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPER 873 ++APE+ G KY SVD ++FG+L + + G +D L+ ++R P Sbjct: 514 YIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPF-----HGDDEDELFESIRVDT-PHY 567 Query: 874 LPVFDEECWQLMEACWDGDPLKR 896 +E ++E ++ +P KR Sbjct: 568 PRWITKESKDILEKLFEREPTKR 590 >gi|31377782 protein kinase C, delta [Homo sapiens] Length = 676 Score = 79.3 bits (194), Expect = 1e-14 Identities = 47/143 (32%), Positives = 78/143 (54%), Gaps = 10/143 (6%) Query: 758 ALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAM---MSGSIVGTPI 814 A +++ G++FLHS+G+++RD+KL NVLLD+ KI D G CK + + GTP Sbjct: 454 AAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPD 513 Query: 815 HMAPELFTG-KYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPER 873 ++APE+ G KY SVD ++FG+L + + G +D L+ ++R P Sbjct: 514 YIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPF-----HGDDEDELFESIRVDT-PHY 567 Query: 874 LPVFDEECWQLMEACWDGDPLKR 896 +E ++E ++ +P KR Sbjct: 568 PRWITKESKDILEKLFEREPTKR 590 >gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [Homo sapiens] Length = 466 Score = 78.6 bits (192), Expect = 3e-14 Identities = 70/251 (27%), Positives = 115/251 (45%), Gaps = 25/251 (9%) Query: 654 LGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDL 713 LG ++G G++G V + G A+K++ L+ + + +HE LV L Sbjct: 196 LGAQIGEGEFGAVLQGEYLGQKV--AVKNIKCDVTAQ---AFLDETAVMTKMQHENLVRL 250 Query: 714 HGSVIDYNYGGGSSIAVLLIMERLHRD-----LYTGLKAGLTLETRLQIALDVVEGIRFL 768 G ++ + ++ME + + L T +A + LQ +L V EG+ +L Sbjct: 251 LGVILHQG--------LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYL 302 Query: 769 HSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPE-LFTGKYDN 827 S+ LVHRD+ +N+L+ + AK++D G K E S APE L GK+ + Sbjct: 303 ESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTS 362 Query: 828 SVDVYAFGILFWYICS-GSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLME 886 DV++FG+L W + S G P+ S + V +G R E LM Sbjct: 363 KSDVWSFGVLLWEVFSYGRAPYPK-----MSLKEVSEAVEKGYRMEPPEGCPGPVHVLMS 417 Query: 887 ACWDGDPLKRP 897 +CW+ +P +RP Sbjct: 418 SCWEAEPARRP 428 >gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [Homo sapiens] Length = 508 Score = 78.6 bits (192), Expect = 3e-14 Identities = 70/251 (27%), Positives = 115/251 (45%), Gaps = 25/251 (9%) Query: 654 LGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDL 713 LG ++G G++G V + G A+K++ L+ + + +HE LV L Sbjct: 238 LGAQIGEGEFGAVLQGEYLGQKV--AVKNIKCDVTAQ---AFLDETAVMTKMQHENLVRL 292 Query: 714 HGSVIDYNYGGGSSIAVLLIMERLHRD-----LYTGLKAGLTLETRLQIALDVVEGIRFL 768 G ++ + ++ME + + L T +A + LQ +L V EG+ +L Sbjct: 293 LGVILHQG--------LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYL 344 Query: 769 HSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPE-LFTGKYDN 827 S+ LVHRD+ +N+L+ + AK++D G K E S APE L GK+ + Sbjct: 345 ESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTS 404 Query: 828 SVDVYAFGILFWYICS-GSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLME 886 DV++FG+L W + S G P+ S + V +G R E LM Sbjct: 405 KSDVWSFGVLLWEVFSYGRAPYPK-----MSLKEVSEAVEKGYRMEPPEGCPGPVHVLMS 459 Query: 887 ACWDGDPLKRP 897 +CW+ +P +RP Sbjct: 460 SCWEAEPARRP 470 >gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [Homo sapiens] Length = 507 Score = 78.6 bits (192), Expect = 3e-14 Identities = 70/251 (27%), Positives = 115/251 (45%), Gaps = 25/251 (9%) Query: 654 LGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDL 713 LG ++G G++G V + G A+K++ L+ + + +HE LV L Sbjct: 237 LGAQIGEGEFGAVLQGEYLGQKV--AVKNIKCDVTAQ---AFLDETAVMTKMQHENLVRL 291 Query: 714 HGSVIDYNYGGGSSIAVLLIMERLHRD-----LYTGLKAGLTLETRLQIALDVVEGIRFL 768 G ++ + ++ME + + L T +A + LQ +L V EG+ +L Sbjct: 292 LGVILHQG--------LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYL 343 Query: 769 HSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPE-LFTGKYDN 827 S+ LVHRD+ +N+L+ + AK++D G K E S APE L GK+ + Sbjct: 344 ESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTS 403 Query: 828 SVDVYAFGILFWYICS-GSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLME 886 DV++FG+L W + S G P+ S + V +G R E LM Sbjct: 404 KSDVWSFGVLLWEVFSYGRAPYPK-----MSLKEVSEAVEKGYRMEPPEGCPGPVHVLMS 458 Query: 887 ACWDGDPLKRP 897 +CW+ +P +RP Sbjct: 459 SCWEAEPARRP 469 >gi|148596974 TXK tyrosine kinase [Homo sapiens] Length = 527 Score = 78.6 bits (192), Expect = 3e-14 Identities = 69/251 (27%), Positives = 111/251 (44%), Gaps = 23/251 (9%) Query: 656 QELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG 715 +E+G GQ+GVV+L + W H A+K++ D E M L H +LV L+G Sbjct: 275 KEIGSGQFGVVHLGE-WRSHIQVAIKAINEGSMSE-EDFIEEAKVMMKL-SHSKLVQLYG 331 Query: 716 SVIDYNYGGGSSIAVLLIMERLHRDLYTGL----KAGLTLETRLQIALDVVEGIRFLHSQ 771 I + ++ E + K L E L + D+ EG+ +L Sbjct: 332 VCIQRK-------PLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERN 384 Query: 772 GLVHRDIKLKNVLLDKQNRAKITDLGFCK---PEAMMSGSIVGTPIHMA-PELFT-GKYD 826 G +HRD+ +N L+ KI+D G + + +S PI + PE+F KY Sbjct: 385 GYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYS 444 Query: 827 NSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLME 886 + DV++FG+L W + + K+P FE S + + G R R + +++M Sbjct: 445 SKSDVWSFGVLMWEVFTEG-KMP--FEN-KSNLQVVEAISEGFRLYRPHLAPMSIYEVMY 500 Query: 887 ACWDGDPLKRP 897 +CW P RP Sbjct: 501 SCWHEKPEGRP 511 >gi|148746218 TAO kinase 3 [Homo sapiens] Length = 898 Score = 78.2 bits (191), Expect = 3e-14 Identities = 58/190 (30%), Positives = 85/190 (44%), Gaps = 19/190 (10%) Query: 657 ELGRGQYGVVYLCDNWGGHFPCALKSVV---PPDEKHWNDLALEFHYMRSLPKHERLVDL 713 E+G G +G VY N A+K + + W D+ E ++R L KH ++ Sbjct: 29 EIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQL-KHPNTIEY 87 Query: 714 HGSVIDYNYGGGSSIAVLLIMERL---HRDLYTGLKAGLTLETRLQIALDVVEGIRFLHS 770 G + + L+ME DL K L I + G+ +LHS Sbjct: 88 KGCYLKEH-------TAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHS 140 Query: 771 QGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF----TGKYD 826 L+HRDIK N+LL + + K+ D G A + S VGTP MAPE+ G+YD Sbjct: 141 HALIHRDIKAGNILLTEPGQVKLADFGSAS-MASPANSFVGTPYWMAPEVILAMDEGQYD 199 Query: 827 NSVDVYAFGI 836 VD+++ GI Sbjct: 200 GKVDIWSLGI 209 >gi|112789548 lymphocyte-specific protein tyrosine kinase precursor [Homo sapiens] Length = 509 Score = 77.4 bits (189), Expect = 6e-14 Identities = 75/270 (27%), Positives = 118/270 (43%), Gaps = 35/270 (12%) Query: 653 KLGQELGRGQYGVVYLCDNWGGHFPCALKSV----VPPDEKHWNDLALEFHYMRSLPKHE 708 KL + LG GQ+G V++ + GH A+KS+ + PD E + M+ L +H+ Sbjct: 246 KLVERLGAGQFGEVWM-GYYNGHTKVAVKSLKQGSMSPDA-----FLAEANLMKQL-QHQ 298 Query: 709 RLVDLHGSVIDYNYGGGSSIAVLLIMERLHRD-----LYTGLKAGLTLETRLQIALDVVE 763 RLV L+ V + + +I E + L T LT+ L +A + E Sbjct: 299 RLVRLYAVV--------TQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE 350 Query: 764 GIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK---PEAMMSGSIVGTPIH-MAPE 819 G+ F+ + +HRD++ N+L+ KI D G + + PI APE Sbjct: 351 GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPE 410 Query: 820 LFT-GKYDNSVDVYAFGILFWYICS-GSVKLPEAFERCASKDHLWNNVRRGARPERLPVF 877 G + DV++FGIL I + G + P + + N+ RG R R Sbjct: 411 AINYGTFTIKSDVWSFGILLTEIVTHGRIPYPG-----MTNPEVIQNLERGYRMVRPDNC 465 Query: 878 DEECWQLMEACWDGDPLKRPLLGIVQPMLQ 907 EE +QLM CW P RP ++ +L+ Sbjct: 466 PEELYQLMRLCWKERPEDRPTFDYLRSVLE 495 >gi|112789546 lymphocyte-specific protein tyrosine kinase precursor [Homo sapiens] Length = 509 Score = 77.4 bits (189), Expect = 6e-14 Identities = 75/270 (27%), Positives = 118/270 (43%), Gaps = 35/270 (12%) Query: 653 KLGQELGRGQYGVVYLCDNWGGHFPCALKSV----VPPDEKHWNDLALEFHYMRSLPKHE 708 KL + LG GQ+G V++ + GH A+KS+ + PD E + M+ L +H+ Sbjct: 246 KLVERLGAGQFGEVWM-GYYNGHTKVAVKSLKQGSMSPDA-----FLAEANLMKQL-QHQ 298 Query: 709 RLVDLHGSVIDYNYGGGSSIAVLLIMERLHRD-----LYTGLKAGLTLETRLQIALDVVE 763 RLV L+ V + + +I E + L T LT+ L +A + E Sbjct: 299 RLVRLYAVV--------TQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE 350 Query: 764 GIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK---PEAMMSGSIVGTPIH-MAPE 819 G+ F+ + +HRD++ N+L+ KI D G + + PI APE Sbjct: 351 GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPE 410 Query: 820 LFT-GKYDNSVDVYAFGILFWYICS-GSVKLPEAFERCASKDHLWNNVRRGARPERLPVF 877 G + DV++FGIL I + G + P + + N+ RG R R Sbjct: 411 AINYGTFTIKSDVWSFGILLTEIVTHGRIPYPG-----MTNPEVIQNLERGYRMVRPDNC 465 Query: 878 DEECWQLMEACWDGDPLKRPLLGIVQPMLQ 907 EE +QLM CW P RP ++ +L+ Sbjct: 466 PEELYQLMRLCWKERPEDRPTFDYLRSVLE 495 >gi|102469034 janus kinase 1 [Homo sapiens] Length = 1154 Score = 77.4 bits (189), Expect = 6e-14 Identities = 78/269 (28%), Positives = 121/269 (44%), Gaps = 36/269 (13%) Query: 656 QELGRGQYGVVYLC------DNWGGHFPCALKSVVPPDE-KHWNDLALEFHYMRSLPKHE 708 ++LG G +G V LC DN G A+KS+ P H DL E +R+L HE Sbjct: 879 RDLGEGHFGKVELCRYDPEGDNTGEQV--AVKSLKPESGGNHIADLKKEIEILRNL-YHE 935 Query: 709 RLVDLHGSVIDYNYGGGSSIAVLLIMERLH----RDLYTGLKAGLTLETRLQIALDVVEG 764 +V G + GG+ I LIME L ++ K + L+ +L+ A+ + +G Sbjct: 936 NIVKYKGICTE---DGGNGIK--LIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKG 990 Query: 765 IRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK-----PEAMMSGSIVGTPIH-MAP 818 + +L S+ VHRD+ +NVL++ +++ KI D G K E +P+ AP Sbjct: 991 MDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAP 1050 Query: 819 E-LFTGKYDNSVDVYAFGILFWYI---CSGSVKLPEAFERCASKDH-------LWNNVRR 867 E L K+ + DV++FG+ + C F + H L N ++ Sbjct: 1051 ECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKE 1110 Query: 868 GARPERLPVFDEECWQLMEACWDGDPLKR 896 G R P +E +QLM CW+ P R Sbjct: 1111 GKRLPCPPNCPDEVYQLMRKCWEFQPSNR 1139 Score = 47.8 bits (112), Expect = 5e-05 Identities = 68/297 (22%), Positives = 120/297 (40%), Gaps = 37/297 (12%) Query: 645 DVLLHRKPKLGQELGRGQYGVVY------LCDNWGGHFPCALKSVVPPDEKHWNDLALEF 698 D +L + G+ LGRG +Y D+ G +K ++ + D++L F Sbjct: 576 DRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAF 635 Query: 699 HYMRSLPK---HERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAG-LTLETR 754 S+ + H+ +V L+G + +I V +E DL+ K+ LT + Sbjct: 636 FEAASMMRQVSHKHIVYLYGVCVR----DVENIMVEEFVEGGPLDLFMHRKSDVLTTPWK 691 Query: 755 LQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQN-------RAKITDLGFCKPEAMMSG 807 ++A + + +L + LVH ++ KN+LL ++ K++D G Sbjct: 692 FKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQE 751 Query: 808 SIVGTPIHMAPELFTGKYDNSV--DVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNV 865 I P +APE + SV D ++FG W IC ++P + K+ + + Sbjct: 752 CIERIP-WIAPECVEDSKNLSVAADKWSFGTTLWEICYNG-EIPLKDKTLIEKERFYESR 809 Query: 866 RRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNRLCKSNSEQPN 922 R P +E LM C + DP +R P + IM + K + P+ Sbjct: 810 CRPVTPS-----CKELADLMTRCMNYDPNQR-------PFFRAIMRDINKLEEQNPD 854 >gi|187475373 c-src tyrosine kinase [Homo sapiens] Length = 450 Score = 77.4 bits (189), Expect = 6e-14 Identities = 75/248 (30%), Positives = 116/248 (46%), Gaps = 15/248 (6%) Query: 653 KLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVD 712 KL Q +G+G++G V L D G A+K + ++ E M L +H LV Sbjct: 196 KLLQTIGKGEFGDVMLGDYRGNKV--AVKCI--KNDATAQAFLAEASVMTQL-RHSNLVQ 250 Query: 713 LHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQG 772 L G +++ GG + + L L + ++ L + L+ +LDV E + +L Sbjct: 251 LLGVIVEEK-GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 Query: 773 LVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIH-MAPE-LFTGKYDNSVD 830 VHRD+ +NVL+ + N AK++D G K EA + P+ APE L K+ D Sbjct: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTK-EASSTQDTGKLPVKWTAPEALREKKFSTKSD 368 Query: 831 VYAFGILFWYICS-GSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACW 889 V++FGIL W I S G V P R KD + V +G + + +++M+ CW Sbjct: 369 VWSFGILLWEIYSFGRVPYP----RIPLKD-VVPRVEKGYKMDAPDGCPPAVYEVMKNCW 423 Query: 890 DGDPLKRP 897 D RP Sbjct: 424 HLDAAMRP 431 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.136 0.411 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 36,371,995 Number of Sequences: 37866 Number of extensions: 1678578 Number of successful extensions: 6761 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 645 Number of HSP's successfully gapped in prelim test: 175 Number of HSP's that attempted gapping in prelim test: 5099 Number of HSP's gapped (non-prelim): 1092 length of query: 929 length of database: 18,247,518 effective HSP length: 112 effective length of query: 817 effective length of database: 14,006,526 effective search space: 11443331742 effective search space used: 11443331742 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.