Search of human proteins with 40538794

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40538794 coiled-coil domain containing 21 [Homo sapiens]
         (762 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40538794 coiled-coil domain containing 21 [Homo sapiens]          1505   0.0  
gi|109715852 chromosome 6 open reading frame 204 isoform a [Homo...   370   e-102
gi|109715849 chromosome 6 open reading frame 204 isoform b [Homo...   136   8e-32
gi|21735548 centrosomal protein 2 [Homo sapiens]                       86   1e-16
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         83   1e-15
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]    82   1e-15
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    81   4e-15
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    79   1e-14
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    79   2e-14
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    79   2e-14
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    79   2e-14
gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [...    79   2e-14
gi|157311604 phosphodiesterase 4D interacting protein isoform 1 ...    79   2e-14
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    78   3e-14
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    78   3e-14
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                78   3e-14
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]    78   3e-14
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    77   8e-14
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    76   1e-13
gi|38044112 restin isoform b [Homo sapiens]                            75   2e-13
gi|4506751 restin isoform a [Homo sapiens]                             75   2e-13
gi|4504063 golgin 97 [Homo sapiens]                                    75   2e-13
gi|45439327 periplakin [Homo sapiens]                                  75   2e-13
gi|148746195 trichohyalin [Homo sapiens]                               75   3e-13
gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [...    75   3e-13
gi|31982906 cingulin-like 1 [Homo sapiens]                             74   4e-13
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    74   4e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        74   5e-13
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        74   5e-13
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         74   5e-13

>gi|40538794 coiled-coil domain containing 21 [Homo sapiens]
          Length = 762

 Score = 1505 bits (3896), Expect = 0.0
 Identities = 762/762 (100%), Positives = 762/762 (100%)

Query: 1   MAMQEKYPTEGISHVTSPSSDVIQKGSSLGTEWQTPVISEPFRSRFSRCSSVADSGDTAI 60
           MAMQEKYPTEGISHVTSPSSDVIQKGSSLGTEWQTPVISEPFRSRFSRCSSVADSGDTAI
Sbjct: 1   MAMQEKYPTEGISHVTSPSSDVIQKGSSLGTEWQTPVISEPFRSRFSRCSSVADSGDTAI 60

Query: 61  GTSCSDIAEDFCSSSGSPPFQPIKSHVTIPTAHVMPSTLGTSPAKPNSTPVGPSSSKLPL 120
           GTSCSDIAEDFCSSSGSPPFQPIKSHVTIPTAHVMPSTLGTSPAKPNSTPVGPSSSKLPL
Sbjct: 61  GTSCSDIAEDFCSSSGSPPFQPIKSHVTIPTAHVMPSTLGTSPAKPNSTPVGPSSSKLPL 120

Query: 121 SGLAESVGMTRNGDLGAMKHSPGLSRDLMYFSGATGENGIEQSWFPAVGHERQEEARKFD 180
           SGLAESVGMTRNGDLGAMKHSPGLSRDLMYFSGATGENGIEQSWFPAVGHERQEEARKFD
Sbjct: 121 SGLAESVGMTRNGDLGAMKHSPGLSRDLMYFSGATGENGIEQSWFPAVGHERQEEARKFD 180

Query: 181 IPSMESTLNQSAMMETLYSDPHHRVRFHNPRTSTSKELYRVLPEAKKAPGSGAVFERNGP 240
           IPSMESTLNQSAMMETLYSDPHHRVRFHNPRTSTSKELYRVLPEAKKAPGSGAVFERNGP
Sbjct: 181 IPSMESTLNQSAMMETLYSDPHHRVRFHNPRTSTSKELYRVLPEAKKAPGSGAVFERNGP 240

Query: 241 HSNSSGVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQSCELSTCRQQLELIRLQMEQM 300
           HSNSSGVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQSCELSTCRQQLELIRLQMEQM
Sbjct: 241 HSNSSGVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQSCELSTCRQQLELIRLQMEQM 300

Query: 301 QLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRE 360
           QLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRE
Sbjct: 301 QLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRE 360

Query: 361 SELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASE 420
           SELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASE
Sbjct: 361 SELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASE 420

Query: 421 VEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLE 480
           VEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLE
Sbjct: 421 VEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLE 480

Query: 481 RYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQR 540
           RYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQR
Sbjct: 481 RYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQR 540

Query: 541 EAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSL 600
           EAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSL
Sbjct: 541 EAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSL 600

Query: 601 EQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGS 660
           EQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGS
Sbjct: 601 EQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGS 660

Query: 661 PPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDL 720
           PPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDL
Sbjct: 661 PPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDL 720

Query: 721 QKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ 762
           QKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ
Sbjct: 721 QKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ 762


>gi|109715852 chromosome 6 open reading frame 204 isoform a [Homo
           sapiens]
          Length = 805

 Score =  370 bits (949), Expect = e-102
 Identities = 277/789 (35%), Positives = 429/789 (54%), Gaps = 82/789 (10%)

Query: 33  WQTPVISEPFRSRFSRCSSVA-DSGDTAIGTSCSDIAEDFCSSSGSPPFQPIKSHVTIPT 91
           WQ   +    R+   R  S+A DSGDT IGTSCSD  ED  +SSG+  F+P +S +T+PT
Sbjct: 40  WQATTVPSNHRNNHIRRHSIASDSGDTGIGTSCSDSVEDHSTSSGTLSFKPSQSLITLPT 99

Query: 92  AHVMPSTLGTSPAKPNSTPVGPSSSKLPLSGLAESVGMTRNG---------DLGAMKHSP 142
           AHVMPS    S +K   + + P  SK   S L +++G    G         D   ++   
Sbjct: 100 AHVMPSNSSASISKLRES-LTPDGSKWSTS-LMQTLGNHSRGEQDSSLDMKDFRPLRKWS 157

Query: 143 GLSRDLMYFSGATG--------ENGIEQ------------SWFPAVGHERQEEARKFDIP 182
            LS+     +   G         NG+E+            +  P+  H+  E  R  D  
Sbjct: 158 SLSKLTAPDNCGQGGTVCREESRNGLEKIGKAKALTSQLRTIGPSCLHDSMEMLRLED-- 215

Query: 183 SMESTLNQSAMMETLY-----SDPHHRVRFHNPRTSTSKELYRVLPEAKKAPGSGAVFER 237
             E    +S+ ++  Y     S    R      R       Y  LPE+K    S   FE 
Sbjct: 216 -KEINKKRSSTLDCKYKFESCSKEDFRASSSTLRRQPVDMTYSALPESKPIMTSSEAFE- 273

Query: 238 NGPHSNSSGVLPLGLQPAPG--LSKPLPSQVW-----QPSPDTWHPREQSCELSTCRQQ- 289
                     L LG Q   G  +   + +Q+W     + +P      E S  L+  +QQ 
Sbjct: 274 ------PPKYLMLGQQAVGGVPIQPSVRTQMWLTEQLRTNPLEGRNTEDSYSLAPWQQQQ 327

Query: 290 LELIRLQMEQ-MQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQR 348
           +E  R   E  MQ+  G+      ++ P     + ++W S+L   E LL++KE++ID+Q+
Sbjct: 328 IEDFRQGSETPMQVLTGS---SRQSYSPGYQ--DFSKWESMLKIKEGLLRQKEIVIDRQK 382

Query: 349 KHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSRE 408
           + I+ L +++R++EL+   A+LG      D  +  LQ  Q ENT L+  F++++ + S++
Sbjct: 383 QQITHLHERIRDNELRAQHAMLGHYVNCEDSYVASLQP-QYENTSLQTPFSEESVSHSQQ 441

Query: 409 KIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQ 468
             + E+KL+++E EV  + E LK  L   SEE KK EE++K RD++I++LKKKCQKESEQ
Sbjct: 442 G-EFEQKLASTEKEVLQLNEFLKQRLSLFSEEKKKLEEKLKTRDRYISSLKKKCQKESEQ 500

Query: 469 NREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICR 528
           N+EKQ+RIETLE+YLADLPTL+D Q QS QL+  E K+  LQE + + E  LEE +  C+
Sbjct: 501 NKEKQRRIETLEKYLADLPTLDDVQSQSLQLQILEEKNKNLQEALIDTEKKLEEIKKQCQ 560

Query: 529 EKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEG---PEVEMESWQKRYDSLQ----- 580
           +KE QL   +++E E  +   SLQ  Q VE    +G   P ++ +  Q   D+L+     
Sbjct: 561 DKETQLICQKKKEKELVTTVQSLQ--QKVERCLEDGIRLPMLDAKQLQNENDNLRQQNET 618

Query: 581 --KIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQ 638
             KI++ QQ ++D++  ++QS++ ++++E+ T+Q + EE ++++  +Q+L  A+ E   Q
Sbjct: 619 ASKIIDSQQDEIDRMILEIQSMQGKLSKEKLTTQKMMEELEKKERNVQRLTKALLENQRQ 678

Query: 639 NQD---LIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRA 695
             +   L+++     +  +Q      P  D   +  +L +E++ CL DL+A+CSI+ QRA
Sbjct: 679 TDETCSLLDQGQEPDQSRQQTVLSKRPLFDLTVID-QLFKEMSCCLFDLKALCSILNQRA 737

Query: 696 QGHDPNLSLLLGIHS--AQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQ 753
           QG +PNLSLLLGI S      ET+ D    + + +KL +V QLRRDI++LRTT+SDRYAQ
Sbjct: 738 QGKEPNLSLLLGIRSMNCSAEETEND-HSTETLTKKLSDVCQLRRDIDELRTTISDRYAQ 796

Query: 754 DMGENCVTQ 762
           DMG+NC+TQ
Sbjct: 797 DMGDNCITQ 805


>gi|109715849 chromosome 6 open reading frame 204 isoform b [Homo
           sapiens]
          Length = 496

 Score =  136 bits (342), Expect = 8e-32
 Identities = 137/460 (29%), Positives = 214/460 (46%), Gaps = 63/460 (13%)

Query: 33  WQTPVISEPFRSRFSRCSSVA-DSGDTAIGTSCSDIAEDFCSSSGSPPFQPIKSHVTIPT 91
           WQ   +    R+   R  S+A DSGDT IGTSCSD  ED  +SSG+  F+P +S +T+PT
Sbjct: 40  WQATTVPSNHRNNHIRRHSIASDSGDTGIGTSCSDSVEDHSTSSGTLSFKPSQSLITLPT 99

Query: 92  AHVMPSTLGTSPAKPNSTPVGPSSSKLPLSGLAESVGMTRNG---------DLGAMKHSP 142
           AHVMPS    S +K   + + P  SK   S L +++G    G         D   ++   
Sbjct: 100 AHVMPSNSSASISKLRES-LTPDGSKWSTS-LMQTLGNHSRGEQDSSLDMKDFRPLRKWS 157

Query: 143 GLSRDLMYFSGATG--------ENGIEQ------------SWFPAVGHERQEEARKFDIP 182
            LS+     +   G         NG+E+            +  P+  H+  E  R  D  
Sbjct: 158 SLSKLTAPDNCGQGGTVCREESRNGLEKIGKAKALTSQLRTIGPSCLHDSMEMLRLED-- 215

Query: 183 SMESTLNQSAMMETLY-----SDPHHRVRFHNPRTSTSKELYRVLPEAKKAPGSGAVFER 237
             E    +S+ ++  Y     S    R      R       Y  LPE+K    S   FE 
Sbjct: 216 -KEINKKRSSTLDCKYKFESCSKEDFRASSSTLRRQPVDMTYSALPESKPIMTSSEAFE- 273

Query: 238 NGPHSNSSGVLPLGLQPAPG--LSKPLPSQVW-----QPSPDTWHPREQSCELSTCRQQ- 289
                     L LG Q   G  +   + +Q+W     + +P      E S  L+  +QQ 
Sbjct: 274 ------PPKYLMLGQQAVGGVPIQPSVRTQMWLTEQLRTNPLEGRNTEDSYSLAPWQQQQ 327

Query: 290 LELIRLQMEQ-MQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQR 348
           +E  R   E  MQ+  G+      ++ P     + ++W S+L   E LL++KE++ID+Q+
Sbjct: 328 IEDFRQGSETPMQVLTGS---SRQSYSPGYQ--DFSKWESMLKIKEGLLRQKEIVIDRQK 382

Query: 349 KHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSRE 408
           + I+ L +++R++EL+   A+LG      D  +  LQ  Q ENT L+  F++++ + S++
Sbjct: 383 QQITHLHERIRDNELRAQHAMLGHYVNCEDSYVASLQP-QYENTSLQTPFSEESVSHSQQ 441

Query: 409 KIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERV 448
             + E+KL+++E EV  + E LK  L   SEE KK EE+V
Sbjct: 442 G-EFEQKLASTEKEVLQLNEFLKQRLSLFSEEKKKLEEKV 480


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 94/419 (22%), Positives = 195/419 (46%), Gaps = 46/419 (10%)

Query: 336  LLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLR 395
            +L++KE  ++ Q++HI +L+    E + Q+   L G     G+  LL L + ++E   L+
Sbjct: 1730 ILRDKEKEVECQQEHIHELQ----ELKDQLEQQLQGLHRKVGETSLL-LSQREQEIVVLQ 1784

Query: 396  AQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHI 455
             Q  +  E    ++  L+ +L  ++  +    + L+ ALQ+  ++ + QEERVK +    
Sbjct: 1785 QQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELE-ALQQEQQQAQGQEERVKEK---- 1839

Query: 456  NNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTE 515
                     ++ Q   +Q  +   ER+      L+DH++Q+++L++          +V  
Sbjct: 1840 --------ADALQGALEQAHMTLKERH----GELQDHKEQARRLEEELAVEGR---RVQA 1884

Query: 516  LESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKR 575
            LE +L + +A  RE+E  L +L+Q+ AE                   +  EVE  + Q  
Sbjct: 1885 LEEVLGDLRAESREQEKALLALQQQCAE-----------------QAQEHEVETRALQDS 1927

Query: 576  YDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKEL 635
            +   Q +++++ Q+++ LR++ QS   +       ++AL+E   +  +ALQ     + E 
Sbjct: 1928 WLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQ 1987

Query: 636  SVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLAL-ELHQELASCLQDLQAVCSIVTQR 694
            +  ++ L     TLQ  L   Q  S    +  ++   E+  +     +D+Q +   + QR
Sbjct: 1988 AELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQR 2047

Query: 695  AQ--GHDPNLSLLLGIHSAQHPETQLDLQKPDV-IKRKLEEVQQLRRDIEDLRTTMSDR 750
             +   H      LL    AQ  +  +  +K ++  +R+ EE++ L + + +L+ T++ +
Sbjct: 2048 DEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK 2106



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 99/436 (22%), Positives = 189/436 (43%), Gaps = 72/436 (16%)

Query: 330  LNSNEHLLKEKELLIDKQRKHISQL--EQKVRESELQVHSALLGRPAPFGDVCLLRLQEL 387
            +   + L+KE E   + QR  ++ L  + + R  ELQ  S+ +        V    LQE 
Sbjct: 1569 MECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQER 1628

Query: 388  QRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEE- 446
             +E    R Q     E L R+K  L + L   + E+ L +E ++V   + + + K  EE 
Sbjct: 1629 DQEVKSQREQI----EELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEED 1684

Query: 447  ------RVKGRDKHINNLKKKCQKESEQNR--EKQQR--IETLERYLAD----LPTLEDH 492
                   ++ R + +   ++  Q+ +E+ +   K QR  +E ++  L D    +   ++H
Sbjct: 1685 LEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEH 1744

Query: 493  QKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQ 552
              + Q+LKD      +L++++  L   + ET  +  ++E ++  L+Q+  E    G    
Sbjct: 1745 IHELQELKD------QLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG---- 1794

Query: 553  DKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQ 612
                         E++ +S Q + D  Q+ + ++ Q+++       +L+QE  Q +G  +
Sbjct: 1795 -------------ELKEQSLQSQLDEAQRALAQRDQELE-------ALQQEQQQAQGQEE 1834

Query: 613  ALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHL----RQAQPGSPPSPDTAQ 668
             ++E+A     AL+Q    +KE   + QD  E+   L+E L    R+ Q       D   
Sbjct: 1835 RVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRA 1894

Query: 669  LALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKR 728
             + E  + L +    LQ  C+   ++AQ H+     L              LQ   V+K 
Sbjct: 1895 ESREQEKALLA----LQQQCA---EQAQEHEVETRAL----------QDSWLQAQAVLKE 1937

Query: 729  KLEEVQQLRRDIEDLR 744
            + +E++ LR + +  R
Sbjct: 1938 RDQELEALRAESQSSR 1953



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 87/352 (24%), Positives = 159/352 (45%), Gaps = 47/352 (13%)

Query: 385  QELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQ 444
            ++ ++E ++ + + A+  E+L REK++LE +L   + E++        A+Q   EE + Q
Sbjct: 860  EKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEME--------AIQAQREEERTQ 911

Query: 445  EERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLK-DSE 503
             E               CQ + E  +E   R+  LE  L     L D  +Q ++L+ D +
Sbjct: 912  AE------------SALCQMQLETEKE---RVSLLETLLQTQKELADASQQLERLRQDMK 956

Query: 504  LKSTELQEKVTELESLLEETQAICREKEIQ-LESLRQREAEFSSAGHSLQDKQSVEETSG 562
            ++  + QE    L++ L+E Q   +E   Q  + L   + E SS    LQDK  +++   
Sbjct: 957  VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSL---LQDKMDLQK--- 1010

Query: 563  EGPEVE-MESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRR 621
               +VE ++S     D  Q++VE++ Q+  +   +   +++E+ +E+ +      E ++R
Sbjct: 1011 ---QVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQR 1067

Query: 622  DSALQQLRT-AVKELSVQNQDLIE-----KNLTLQEHLRQAQPGSPPSPDTAQLALELHQ 675
               LQ+  +   +ELS   QD+ E     K L+ Q  L + +     +   AQ A  L +
Sbjct: 1068 LLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEE 1127

Query: 676  ELASCLQDLQAVCSIVTQRAQGHDPNLSL------LLGIHSAQHPETQLDLQ 721
              AS + + Q   S+  Q A+     L L      L  + + Q P  Q   Q
Sbjct: 1128 LEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ 1179



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 112/488 (22%), Positives = 198/488 (40%), Gaps = 52/488 (10%)

Query: 282 ELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKE 341
           +L+ C++ + L++ Q +Q + +  A+             L   Q + +    + L KE+E
Sbjct: 408 QLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLA-GQTVDLQGEVDSLSKERE 466

Query: 342 LLIDKQRKHISQLEQKVRES--------ELQVHS-ALLGRPAPFGDVCLLRLQELQRENT 392
           LL   + +   QLE   +E+        ELQ+   +  G+     +   L ++E +R   
Sbjct: 467 LLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQE 526

Query: 393 FLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRES---LKVALQKHSEEVKKQEERVK 449
            L    A+++E+LS E I L + L +S +E +L+R+    +  AL +  + + +      
Sbjct: 527 MLMGLEAKQSESLS-ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSEN 585

Query: 450 GRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTEL 509
                + +L+    K S  N         L + L  L   E++Q    +++ +E     L
Sbjct: 586 TLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLE--EENQSVCSRMEAAEQARNAL 643

Query: 510 QEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQ-DKQSVEETSGEGPEVE 568
           Q  + E E   E       EK   LE+  Q+  E   AG  LQ D + ++E        E
Sbjct: 644 QVDLAEAEKRREALW----EKNTHLEAQLQKAEE---AGAELQADLRDIQE--------E 688

Query: 569 MESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQL 628
            E  QK+    +   E    +++QL  + +  E+ +A+     +AL  E    +  LQ +
Sbjct: 689 KEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAV 748

Query: 629 RTAVKELSVQNQDLIEKNLTLQEHLRQAQPGS----------PPSPDTAQLALELHQELA 678
               ++L+ Q Q L      L+  L +AQ  +               T   A E+ Q   
Sbjct: 749 ERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEV 808

Query: 679 SCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSA-QHPETQLDLQKPDVIKRKLEEVQQLR 737
            CL+       + T+R+Q      +    +  A Q  +T L+ QK    K    EV QLR
Sbjct: 809 RCLK-----LELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEK----EVNQLR 859

Query: 738 RDIEDLRT 745
              E  R+
Sbjct: 860 EKWEKERS 867



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 116/515 (22%), Positives = 211/515 (40%), Gaps = 116/515 (22%)

Query: 282  ELSTCRQQLELIRLQMEQMQLQ--------------NGAICHHPAAFGPSLPILEP---- 323
            +LS  R Q E    Q+EQ+  +                A+    AA    L  +E     
Sbjct: 695  KLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQD 754

Query: 324  -AQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLL 382
             A+ +  L+S + LL+    L + Q+++ S +E    + E+Q+ +    +    G+V  L
Sbjct: 755  LAEQLQGLSSAKELLESS--LFEAQQQN-SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCL 811

Query: 383  RLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVK 442
            +L EL  E    R+Q  Q+ +A +R+       L+ +E E +   E  K A         
Sbjct: 812  KL-ELDTE----RSQAEQERDAAARQ-------LAQAEQEGKTALEQQKAA--------- 850

Query: 443  KQEERVKGRDKHINNLKKKCQKE-SEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKD 501
                     +K +N L++K +KE S   +E  + +E+LER   +L       +  +Q  +
Sbjct: 851  --------HEKEVNQLREKWEKERSWHQQELAKALESLEREKMEL-----EMRLKEQQTE 897

Query: 502  SELKSTELQEKVTELESLLEETQAICREKEIQLE----------SLRQREAEFSSAGHSL 551
             E    + +E+ T+ ES      A+C   ++QLE          +L Q + E + A   L
Sbjct: 898  MEAIQAQREEERTQAES------ALC---QMQLETEKERVSLLETLLQTQKELADASQQL 948

Query: 552  Q--------DKQSVEETSG-------EGPEVEMESWQKRYDSLQKIVEKQ----QQKMDQ 592
            +         K   +ET+G       E      E+ ++  D L  + E+     Q KMD 
Sbjct: 949  ERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMD- 1007

Query: 593  LRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEH 652
            L+ QV+ L+ ++  ++ + + + +E Q +    Q+     KEL  +   L    +  ++ 
Sbjct: 1008 LQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQR 1067

Query: 653  LRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQ 712
            L   Q       D+ +      QEL++  QD+        Q AQG    LS  + +   +
Sbjct: 1068 LLVLQ-----EADSIR-----QQELSALRQDM--------QEAQGEQKELSAQMELLRQE 1109

Query: 713  HPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTM 747
              E + D    +   + LEE++      + LR ++
Sbjct: 1110 VKEKEADFLAQEA--QLLEELEASHITEQQLRASL 1142



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 90/435 (20%), Positives = 183/435 (42%), Gaps = 53/435 (12%)

Query: 339  EKELLIDKQRKHISQLEQKVRESEL-QVHSALLGRPAPFGDVCLLRLQELQRENTFLRA- 396
            +++L  +++ K   + +Q   ESEL ++H  +    +      L R+ E Q E   L+A 
Sbjct: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM-EAQGERELLQAA 1349

Query: 397  --QFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKH 454
                  + E L    ++   + SA+ +  + +R + + AL+  +EEV+ + ER +   + 
Sbjct: 1350 KENLTAQVEHLQAAVVEARAQASAAGILEEDLRTA-RSALKLKNEEVESERERAQALQEQ 1408

Query: 455  INNLKKKCQKESEQN--------REKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKS 506
               LK    K  ++N         E+++ +ETL   + +L    + QK + +L   +LK 
Sbjct: 1409 -GELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKK 1467

Query: 507  TEL-----QEKVTELE---SLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVE 558
                    QE++ ELE   S+LE      +E+E +L   R++  E               
Sbjct: 1468 RNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIREL-------------- 1513

Query: 559  ETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEA 618
                   E + E+ +   +     +EK+ Q ++  R QVQ L++++   E  +  L E  
Sbjct: 1514 -------EKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENH 1566

Query: 619  QRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELA 678
             + +   + ++    +   Q   L    L L+E  ++ Q  S    D    +  L +EL 
Sbjct: 1567 HKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQ 1626

Query: 679  SCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDV---IKRKLEEVQQ 735
               Q+++      +QR Q  +            +  + +L LQK  +     ++  + + 
Sbjct: 1627 ERDQEVK------SQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKI 1680

Query: 736  LRRDIEDLRTTMSDR 750
            L  D+E ++ ++ +R
Sbjct: 1681 LEEDLEQIKLSLRER 1695



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 112/443 (25%), Positives = 184/443 (41%), Gaps = 57/443 (12%)

Query: 277  REQSCELSTCRQQLELIR----LQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNS 332
            REQ  E+   +QQL+  R    L+ + +Q Q        A     L  L+  Q  +    
Sbjct: 1776 REQ--EIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQA--QG 1831

Query: 333  NEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENT 392
             E  +KEK   +    +  + +  K R  ELQ H     R      V   R+Q L+    
Sbjct: 1832 QEERVKEKADALQGALEQ-AHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLG 1890

Query: 393  FLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRD 452
             LRA+  ++ +AL   +    ++    EVE + +++S   A           +  +K RD
Sbjct: 1891 DLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQA-----------QAVLKERD 1939

Query: 453  KHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEK 512
            + +  L+ + Q    Q    + R E L+  L         ++Q   L+ +EL S  L+  
Sbjct: 1940 QELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQ-HLLEQAEL-SRSLEAS 1997

Query: 513  VTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQ-DKQSVEETSGEGPEVEMES 571
               L++ L+  QA  R+ E   E+LR +E E        Q D Q +++   +  E E+  
Sbjct: 1998 TATLQASLDACQAHSRQLE---EALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE-ELRH 2053

Query: 572  WQKRYDSLQKIV-----------------EKQQQKMDQLRSQVQSLEQEVAQEEGTSQAL 614
             Q+R   L+K +                 E++++++  L   V+ L+  +AQ+E     L
Sbjct: 2054 QQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILEL 2113

Query: 615  REEAQRRDSALQQLRTAVKELSVQNQ----DLIEKNL-----TLQEHLRQAQPGSPPSPD 665
            RE  QR +  L+ L  + K   ++ Q    D +E  L      LQ  LRQ +       +
Sbjct: 2114 RETQQRNN--LEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWRE 2171

Query: 666  TAQ-LALELHQELASCLQDLQAV 687
             AQ LAL L Q  AS +  LQ V
Sbjct: 2172 KAQDLALSLAQTKAS-VSSLQEV 2193



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 93/397 (23%), Positives = 167/397 (42%), Gaps = 61/397 (15%)

Query: 282  ELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKE 341
            E  + R Q E  R + E +Q   G    H A  G    +LE A+    L ++   L+   
Sbjct: 1948 ESQSSRHQEEAARARAEALQEALGKA--HAALQGKEQHLLEQAELSRSLEASTATLQAS- 2004

Query: 342  LLIDKQRKHISQLEQ--KVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFA 399
              +D  + H  QLE+  +++E E+Q                 LR QE  ++   L+   A
Sbjct: 2005 --LDACQAHSRQLEEALRIQEGEIQDQD--------------LRYQEDVQQ---LQQALA 2045

Query: 400  QKTEAL--SREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINN 457
            Q+ E L   +E+  L +K  A  V+  +I+E       K +   +++EE ++G  + +  
Sbjct: 2046 QRDEELRHQQEREQLLEKSLAQRVQENMIQE-------KQNLGQEREEEEIRGLHQSVRE 2098

Query: 458  LKKK-CQKESE--QNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELK----STELQ 510
            L+    QKE E  + RE QQR       L  LP    H  ++  +++  LK       LQ
Sbjct: 2099 LQLTLAQKEQEILELRETQQR-----NNLEALP----HSHKTSPMEEQSLKLDSLEPRLQ 2149

Query: 511  EKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEME 570
             ++  L++ L +T+A   E   + + L    A+  ++  SLQ+     + S    + E +
Sbjct: 2150 RELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQ 2209

Query: 571  SWQKRYDSLQKIVEKQQQKMDQLRSQ----------VQSLEQEVAQEEGTSQALREEAQR 620
              Q   +  ++ +EK++       S           VQ  E    + E +   + +++ R
Sbjct: 2210 RLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWR 2269

Query: 621  RDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 657
            +   L+ L+ AV  L +    L   N+ L+  L Q +
Sbjct: 2270 Q--RLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE 2304



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 112/511 (21%), Positives = 210/511 (41%), Gaps = 94/511 (18%)

Query: 273  TWHPREQSCELSTC-RQQLEL-IRL-----QMEQMQLQNGAICHHPAAFGPSLPILEPAQ 325
            +WH +E +  L +  R+++EL +RL     +ME +Q Q         +    + +    +
Sbjct: 867  SWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKE 926

Query: 326  WISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQ 385
             +S+L +   L  +KEL    Q+    + + KV++ + Q  + +L             L+
Sbjct: 927  RVSLLETL--LQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQ---RELK 981

Query: 386  ELQRENTFLRAQFAQKTEALSREKIDLEK-------KLSASEVEVQLIRESLKVALQKHS 438
            E  R++    A   +++ +L ++K+DL+K       +L A +   +L+ + ++  L++  
Sbjct: 982  EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQ 1041

Query: 439  E--EVKKQEERVKG----------------------RDKHINNLKKKCQKESEQNREKQQ 474
            E   ++K+ ER K                       R + ++ L++  Q+   + +E   
Sbjct: 1042 EYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSA 1101

Query: 475  RIETLERYLAD------------LPTLEDHQKQSQQLKDS----ELKSTELQEKVTELES 518
            ++E L + + +            L  LE      QQL+ S    E K+ +LQ ++   ES
Sbjct: 1102 QMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTES 1161

Query: 519  LLEETQAICR-----EKEIQLESLR-----------QREAEFSSAGHSL-------QDKQ 555
             LE   A  +     + + QL SL            +   E S  G S         D+ 
Sbjct: 1162 QLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQN 1221

Query: 556  SVEETSGEGPEVEMESWQKRYDSLQKIVE---KQQQKMDQLRSQVQSLEQEVAQEEGTSQ 612
                    GP +   S +    +L K+ +   K QQ  D LR QVQ LE+ +   E    
Sbjct: 1222 GARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKS 1281

Query: 613  ALREEAQRRDSALQQ-----LRTAVKELSVQNQ--DLIEKNLTLQEHLRQAQPGSPPSPD 665
             +  E Q     L Q      +   K+ S++++  +L E   +LQ  LR+A+     +  
Sbjct: 1282 QVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG 1341

Query: 666  TAQLALELHQELASCLQDLQAVCSIVTQRAQ 696
              +L     + L + ++ LQA  ++V  RAQ
Sbjct: 1342 ERELLQAAKENLTAQVEHLQA--AVVEARAQ 1370



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 87/428 (20%), Positives = 178/428 (41%), Gaps = 33/428 (7%)

Query: 328 SILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQEL 387
           ++L  ++   ++ E +I   R+ +  LE     +EL  H A L R A       L LQ++
Sbjct: 290 ALLTQSQKQNEDYEKMIKALRETVEILE--TNHTELMEHEASLSRNAQEEK---LSLQQV 344

Query: 388 QRENTFLRAQFAQKTEALSREKIDLEKKLSA-SEVEVQLIRESLKVA---LQKHSEEVKK 443
            ++ T +  +        S  +  LE   S  S+ + Q   ++L +    L +  + V+ 
Sbjct: 345 IKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQD 404

Query: 444 QEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSE 503
             +++ G  + +N L+++  +  E+ +  +QR++ L     +  TL       Q   DS 
Sbjct: 405 LRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLT---GERDTLAGQTVDLQGEVDSL 461

Query: 504 LKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGE 563
            K  EL +K  E             E   QLE L Q           LQ +    +   E
Sbjct: 462 SKERELLQKARE-------------ELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKE 508

Query: 564 GPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDS 623
             + E+    +  + LQ+++   + K  +  S++ +L + +       + LR+E     +
Sbjct: 509 EQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTA 568

Query: 624 ALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQD 683
           AL +   ++ ELS     L  +   L+     A   S  +   A   + L+Q+L    ++
Sbjct: 569 ALARAEQSIAELSSSENTLKTEVADLR---AAAVKLSALNEALALDKVGLNQQLLQLEEE 625

Query: 684 LQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIE-D 742
            Q+VCS +    Q  +   +L + +  A+     L  +K   ++ +L++ ++   +++ D
Sbjct: 626 NQSVCSRMEAAEQARN---ALQVDLAEAEKRREAL-WEKNTHLEAQLQKAEEAGAELQAD 681

Query: 743 LRTTMSDR 750
           LR    ++
Sbjct: 682 LRDIQEEK 689



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 87/421 (20%), Positives = 171/421 (40%), Gaps = 92/421 (21%)

Query: 322 EPAQWISILNSNEH------LLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAP 375
           + A W  + NS E       L+++ +  + + R    +LE+++  +   +         P
Sbjct: 35  QAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEP 94

Query: 376 FGDVCLLRLQELQRE---------------------NTFLRAQFAQKTEALSREKIDLEK 414
             D  L+RL+E Q+                      N  LR    + T   SR + +L +
Sbjct: 95  NLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMR 154

Query: 415 KLSASEVEVQLIRESLK-------------VALQKHSEEVKKQEER--VKGRDKHIN--- 456
           K S  ++E +  +  LK             V  ++H  E+K   +R  ++ + +H+    
Sbjct: 155 KESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSG 214

Query: 457 NLKKKCQKES--EQNREKQQRIETLERYLADLPTL---------EDHQKQSQ--QLKDS- 502
           +L   C + +   Q+RE         R  A L  L         E H++  +  QLK   
Sbjct: 215 SLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQG 274

Query: 503 ELKSTELQEKVTELESLLEETQAICREKEIQLESLRQ------------REAEFSSAGHS 550
           +L+  ELQ++VTEL +LL ++Q    + E  +++LR+             E E S + ++
Sbjct: 275 DLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNA 334

Query: 551 LQDKQSVEET------------------SGEGPEVEMES---WQKRYDSLQKIVEKQQQK 589
            ++K S+++                   SG    +E++S    Q  Y    K +   +  
Sbjct: 335 QEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSV 394

Query: 590 MDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTL 649
           + + R  VQ L Q++A  +     L+++  + +   + LR  +++L+ +   L  + + L
Sbjct: 395 LTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDL 454

Query: 650 Q 650
           Q
Sbjct: 455 Q 455



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 128/624 (20%), Positives = 233/624 (37%), Gaps = 104/624 (16%)

Query: 185  ESTLNQSAMMETLYSDPHHRVRFHNPRTSTSKELYRVLPEAKKAPGSGAVFERNGPHSNS 244
            E T  +SA+ +        RV        T KEL     + ++      V +       +
Sbjct: 908  ERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK--EQET 965

Query: 245  SGVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQSCELSTCRQQLELIRLQMEQMQLQN 304
            +G+L   LQ A    + L     Q   D    +E+S  L   +  L+    Q+E ++ Q 
Sbjct: 966  TGILQTQLQEA---QRELKEAARQHRDDLAALQEESSSLLQDKMDLQK---QVEDLKSQL 1019

Query: 305  GAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQ 364
                    A   S  ++E      +  + E+   +KEL  +K    +S +E++ R   LQ
Sbjct: 1020 -------VAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQ 1072

Query: 365  VHSALLGRPAPFGDVCLLR--LQELQRENTFLRAQFAQKTEALSREKID-------LEKK 415
               ++  +     ++  LR  +QE Q E   L AQ     + +  ++ D       L ++
Sbjct: 1073 EADSIRQQ-----ELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEE 1127

Query: 416  LSASEVEVQLIRESL------KVALQKHSEEVKKQEERVKGRDKHINNLKKKCQK----- 464
            L AS +  Q +R SL         LQ      + Q E +    +  N  + + Q      
Sbjct: 1128 LEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYS 1187

Query: 465  -----------------------------ESEQN--REKQQRIETLERYLADLPTLEDHQ 493
                                         E +QN  R   +R   L    A+      H 
Sbjct: 1188 ALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH- 1246

Query: 494  KQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQD 553
            K  Q L  ++     L+++V +LE  L +T                 EAE S     LQD
Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDT-----------------EAEKSQVHTELQD 1289

Query: 554  KQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQA 613
             Q     + E    E   W+ + +SL+  + +  + M  L+S+++  E +  + +G  + 
Sbjct: 1290 LQRQLSQNQE----EKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGEREL 1345

Query: 614  LREEAQRRDSALQQLRTAVKELSVQNQ--DLIEKNL-TLQEHLRQAQPGSPPSPDTAQLA 670
            L+   +   + ++ L+ AV E   Q     ++E++L T +  L+          + AQ  
Sbjct: 1346 LQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQAL 1405

Query: 671  LELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDV----- 725
             E  +   +  + LQ   +++TQ     +  +  L G    Q  E Q ++QK  +     
Sbjct: 1406 QEQGELKVAQGKALQENLALLTQTLAEREEEVETLRG--QIQELEKQREMQKAALELLSL 1463

Query: 726  -IKRKLEEVQQLRRDIEDLRTTMS 748
             +K++ +EV   +  I++L    S
Sbjct: 1464 DLKKRNQEVDLQQEQIQELEKCRS 1487



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 66/305 (21%), Positives = 117/305 (38%), Gaps = 44/305 (14%)

Query: 487 PTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREA---- 542
           P L + + QS QL         L+E+V  L+  + E QA    K    +  +QR+A    
Sbjct: 6   PGLNNMKPQSLQLV--------LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVR 57

Query: 543 -------EFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRS 595
                  ++ S    L+ +  +E T G  P+      +   D L   +E++QQ+ + L  
Sbjct: 58  KLQAKVLQYRSWCQELEKR--LEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAE 115

Query: 596 QVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAV--KELSVQNQDLIEKNLTLQEHL 653
               L   + + +  ++ALRE+ ++      + R  +  KE   Q +    K     EH 
Sbjct: 116 VNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHG 175

Query: 654 RQ----------AQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLS 703
           R            +        T +  +EL  E       L   C  +T  AQ  +PN S
Sbjct: 176 RLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGS 235

Query: 704 ----------LLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQ 753
                     LLL +   Q  E +   +  ++I+ K +   + + +++D  T +S    Q
Sbjct: 236 GRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLE-KAELQDRVTELSALLTQ 294

Query: 754 DMGEN 758
              +N
Sbjct: 295 SQKQN 299



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 73/395 (18%), Positives = 158/395 (40%), Gaps = 44/395 (11%)

Query: 381 LLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEE 440
           +L LQ+   EN     +  + ++   + +  L +KL A  ++ +   + L+  L+     
Sbjct: 24  VLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGP 83

Query: 441 VKKQEERVKGRDK-----HINNLKKKCQKESEQNREKQQRIET-----------LERYLA 484
           + ++ E V+  +       +   +++C+  +E N + +  +E            +E+   
Sbjct: 84  IPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTV 143

Query: 485 DLPTLEDH--QKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREA 542
           D     D   +K+SQ   + E     L+ +   L SL  E     R   ++++S   R+ 
Sbjct: 144 DWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTF-RRHFLEMKSATDRDL 202

Query: 543 EFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQ 602
               A H       +         + + +  +  +   ++  ++  ++  L ++ Q LE+
Sbjct: 203 MELKAEHVRLSGSLLTCCL----RLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEK 258

Query: 603 EVAQEEGTSQALREEAQRRDSALQQLRTAVKELSV-------QNQDLIEKNLTLQEHLRQ 655
           E  +    SQ L +   + D    +L+  V ELS        QN+D  +    L+E +  
Sbjct: 259 EAHER---SQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEI 315

Query: 656 AQPGSPPSPD-TAQLALELHQELASCLQDLQAVCSIVTQ------RAQGHDPNLSLLLGI 708
            +       +  A L+    +E  S  Q ++ +  ++ +      +  GH+ +L L   I
Sbjct: 316 LETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSI 375

Query: 709 HSA---QHPETQLDLQKPDVIKRKLEEVQQLRRDI 740
            S    Q  +  L L +  V+ R+ + VQ LR+ +
Sbjct: 376 FSQFDYQDADKALTLVR-SVLTRRRQAVQDLRQQL 409


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 103/451 (22%), Positives = 189/451 (41%), Gaps = 74/451 (16%)

Query: 336 LLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLR 395
           LL EK+     + K + +L  K     +++H  L             + Q+L+ E    +
Sbjct: 263 LLNEKQAASPLEPKELEELRDKNESLTMRLHETLK------------QCQDLKTE----K 306

Query: 396 AQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHI 455
           +Q  +K   LS E  DL  KL      +Q ++++L    ++HS+  ++  E+    +K +
Sbjct: 307 SQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKEL 366

Query: 456 NNL--KKKCQKESEQNREKQQRIETLERYLADLPTLEDHQK--------QSQQLKDS--- 502
           +     KKC +  E+N   Q ++  LE +L+ L      +K        Q + LK     
Sbjct: 367 SAALQDKKCLE--EKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAAT 424

Query: 503 -ELKSTELQEKVTELES--------LLEETQAICREKEIQLESLRQREAEFSSAGHSLQD 553
               +T+LQ +V  LE+        LL E      EK+     +   ++  S+   + ++
Sbjct: 425 LAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEE 484

Query: 554 KQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQ----SLEQEVAQEEG 609
            +   +  G     ++ S      +L   +++Q Q++  L+ Q +     L Q + Q+E 
Sbjct: 485 LEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQ 544

Query: 610 TSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQ------AQPGSPPS 663
            SQ LR + ++  S+L+Q    +KE++ + +       T Q+H +Q       +  S   
Sbjct: 545 ASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE------ATRQDHAQQLATAAEEREASLRE 598

Query: 664 PDTAQLALE-LHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQK 722
            D A   LE L +E A+ L+ LQ    +  +                SAQ   TQ   +K
Sbjct: 599 RDAALKQLEALEKEKAAKLEILQQQLQVANEARD-------------SAQTSVTQAQREK 645

Query: 723 PDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQ 753
            + + RK+EE+Q     +E  R    +  AQ
Sbjct: 646 AE-LSRKVEELQAC---VETARQEQHEAQAQ 672



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 107/496 (21%), Positives = 197/496 (39%), Gaps = 93/496 (18%)

Query: 330 LNSNEHLLKEKELL---IDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQE 386
           L   + L ++ E+L   + +  +H+SQL+    + + +V           GDV  L+L+ 
Sbjct: 370 LQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEV----------LGDV--LQLET 417

Query: 387 LQRENTFLRA---QFAQKTEALSREKIDLEKKLSAS----EVEVQLI------------- 426
           L++E   L A   Q   + E L  E+   E KL A     E E Q +             
Sbjct: 418 LKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISN 477

Query: 427 ----RESLKVALQKHSEEVKKQ-----------EERVKGRDKHINNLKKKCQKESEQNRE 471
               +E L+ A Q H   +  Q              ++ +D+ +  LK++ +++  Q  +
Sbjct: 478 LSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQ 537

Query: 472 KQQRIETLERYLA-DLPTLEDHQKQS-QQLKD-SELKSTELQEKVTELESLLEETQAICR 528
             Q+ E   + L   +  L    KQ  QQLK+ +E +    Q+   +L +  EE +A  R
Sbjct: 538 TLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLR 597

Query: 529 EKEIQLESLRQREAEFSSAGHSLQDKQSV-------EETSGEGPEVEMESWQKRYDSLQK 581
           E++  L+ L   E E ++    LQ +  V        +TS    + E     ++ + LQ 
Sbjct: 598 ERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQA 657

Query: 582 IVEKQQQKMDQLRSQVQSLE-------------QEVAQEEG---------------TSQA 613
            VE  +Q+  + ++QV  LE             + VAQE+                T  +
Sbjct: 658 CVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGS 717

Query: 614 LREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALEL 673
           L EE +R   AL++ +  + EL  + + L+E++   ++ L + + G        Q   E 
Sbjct: 718 LEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEA 777

Query: 674 HQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLG-----IHSAQHPETQLDLQKPDVIKR 728
           HQ     L+   A        A+     L   +         +Q  E Q      + +  
Sbjct: 778 HQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMT 837

Query: 729 KLEEVQQLRRDIEDLR 744
             EE ++ R+++++ +
Sbjct: 838 LKEECEKARQELQEAK 853



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 104/501 (20%), Positives = 206/501 (41%), Gaps = 49/501 (9%)

Query: 292  LIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKHI 351
            L+R   EQ +  +  +   PA  G   P     Q      S +  L+  E   ++    +
Sbjct: 922  LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL 981

Query: 352  SQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKID 411
             +L   + ES+ Q       +           +  L +E    +A  A +  A +  ++ 
Sbjct: 982  ERLRAALMESQGQQQEERGQQER--------EVARLTQERGRAQADLALEKAARAELEMR 1033

Query: 412  LEKKLSASEVEVQLIRESLKVALQKHSEEVKKQE-ERVKGRD----KHINNLKKKCQKES 466
            L+  L+   VE   ++E+L  AL +  +E K QE  +++G +    K +  L++  ++  
Sbjct: 1034 LQNALNEQRVEFATLQEALAHALTE--KEGKDQELAKLRGLEAAQIKELEELRQTVKQLK 1091

Query: 467  EQNREKQQ--------RIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELES 518
            EQ  +K++        + E   R     P LE  + +  +L   E +  + QE+   LE 
Sbjct: 1092 EQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKL---EQQCQKQQEQADSLER 1148

Query: 519  LLEETQAICREKEIQLESLR-QREAEFSSAGHSLQDKQSVEE------TSGEGPEVEMES 571
             LE  +A   E++  LE+L+ Q E +    GHS     S +       T  +      + 
Sbjct: 1149 SLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE 1208

Query: 572  WQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALRE----EAQRRDSALQQ 627
            W+ +    ++  E++   +  L  +V  L ++V ++EG S+ L+     E+++     ++
Sbjct: 1209 WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEER 1268

Query: 628  LRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPS-----------PDTAQLALELHQE 676
            LR    E +  +    E++  L+E ++  +  +                 A+ A EL QE
Sbjct: 1269 LRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE 1328

Query: 677  LASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQL 736
            L +  +        ++     H    +L+  +  A+H   QL  ++    KR  EE++Q 
Sbjct: 1329 LKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQS 1388

Query: 737  RRDIEDLRTTMSDRYAQDMGE 757
            ++    LR  +  R  +++GE
Sbjct: 1389 KQAAGGLRAELL-RAQRELGE 1408



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 102/426 (23%), Positives = 172/426 (40%), Gaps = 50/426 (11%)

Query: 337  LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRA 396
            L+EK     K+   +  L +K  E +      L+  PA  GD     L+E Q        
Sbjct: 905  LQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGR------ 958

Query: 397  QFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERV------KG 450
            QF     AL      +E++      E++ +R +L  +  +  EE  +QE  V      +G
Sbjct: 959  QFCSTQAALQA----MEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERG 1014

Query: 451  RDKHINNLKKKCQKESE---QNREKQQRIE--TLERYLADLPTLEDHQKQSQQLKDSELK 505
            R +    L+K  + E E   QN   +QR+E  TL+  LA       H    ++ KD EL 
Sbjct: 1015 RAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA-------HALTEKEGKDQELA 1067

Query: 506  STELQE--KVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGE 563
                 E  ++ ELE L +  + +        E L ++E E +S   S    ++   T   
Sbjct: 1068 KLRGLEAAQIKELEELRQTVKQL-------KEQLAKKEKEHASG--SGAQSEAAGRTEPT 1118

Query: 564  GPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDS 623
            GP  ++E+ +     L++  +KQQ++ D L    +SLE E A       AL     + + 
Sbjct: 1119 GP--KLEALRAEVSKLEQQCQKQQEQADSLE---RSLEAERASRAERDSALETLQGQLEE 1173

Query: 624  ALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQD 683
              Q+L  +   L+   ++L      +Q+H +             Q A E    L S L++
Sbjct: 1174 KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEA-ERKNSLISSLEE 1232

Query: 684  LQAVCSIVTQRAQGHDPNLSLLLGIHS--AQHPETQLDLQKPDVIK---RKLEEVQQLRR 738
              ++ +      +G    L  L+   S  +Q  E +L L + +      R  E    LR 
Sbjct: 1233 EVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALRE 1292

Query: 739  DIEDLR 744
            +++ LR
Sbjct: 1293 EVQSLR 1298



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 80/370 (21%), Positives = 163/370 (44%), Gaps = 73/370 (19%)

Query: 401  KTEALSREKIDLEKKLSASEVEV-QLIRESLKVALQKHSEEVKKQEERVKGR--DKHINN 457
            +TE L RE  +       +E E  QL++E   VA  +   E  +QEE   G    + +  
Sbjct: 781  ETEVLRRELAEAMAAQHTAESECEQLVKE---VAAWRERYEDSQQEEAQYGAMFQEQLMT 837

Query: 458  LKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELE 517
            LK++C+K  ++ +E ++++  +E +                   SEL+ +  Q ++ EL 
Sbjct: 838  LKEECEKARQELQEAKEKVAGIESH-------------------SELQISRQQNELAELH 878

Query: 518  SLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVE---MESWQK 574
            + L       +EKE++ + L    +       +LQ+K +   TS E   +E    ++ ++
Sbjct: 879  ANLARALQQVQEKEVRAQKLADDLS-------TLQEKMAA--TSKEVARLETLVRKAGEQ 929

Query: 575  RYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQE----EGTSQALREEAQRRDSALQQLRT 630
            +  + +++V++  +  D+   Q + LE++  ++    +   QA+  EA++  + L++LR 
Sbjct: 930  QETASRELVKEPARAGDR---QPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA 986

Query: 631  AVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTA---QLALELHQELASCLQD---- 683
            A+ E   Q Q+  E+    +E  R  Q       D A       EL   L + L +    
Sbjct: 987  ALMESQGQQQE--ERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVE 1044

Query: 684  ---LQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDI 740
               LQ   +      +G D  L+ L G+ +AQ                 ++E+++LR+ +
Sbjct: 1045 FATLQEALAHALTEKEGKDQELAKLRGLEAAQ-----------------IKELEELRQTV 1087

Query: 741  EDLRTTMSDR 750
            + L+  ++ +
Sbjct: 1088 KQLKEQLAKK 1097



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 66/302 (21%), Positives = 137/302 (45%), Gaps = 30/302 (9%)

Query: 347  QRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTF--LRAQFAQKTEA 404
            +++H  +LEQ  +++   + + LL      G++  LR +  ++E T   LRA+ A   E 
Sbjct: 1378 EKRHREELEQS-KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQ 1436

Query: 405  LSREK----IDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKK 460
            LS  K    +  E+     E    L R+ L+V L +  E+  ++   V+           
Sbjct: 1437 LSMLKKAHGLLAEENRGLGE-RANLGRQFLEVELDQAREKYVQELAAVRA---DAETRLA 1492

Query: 461  KCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLL 520
            + Q+E+ Q+  ++  + T +   A +  LE+ Q+               QE+  +L + +
Sbjct: 1493 EVQREA-QSTARELEVMTAKYEGAKVKVLEERQR--------------FQEERQKLTAQV 1537

Query: 521  EETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQ 580
            E+ +   RE+  Q+E L ++ A+   A    Q K    +  G   + E +  Q + + LQ
Sbjct: 1538 EQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ 1597

Query: 581  KIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQ 640
              + +++Q  +  + Q++  +     ++  +Q L+E+ +    +L+QL+   KEL  + +
Sbjct: 1598 AQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLR----SLEQLQKENKELRAEAE 1653

Query: 641  DL 642
             L
Sbjct: 1654 RL 1655



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 70/294 (23%), Positives = 131/294 (44%), Gaps = 46/294 (15%)

Query: 364  QVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEV 423
            + H  L       G+   L  Q L+ E    R ++ Q+  A+   + D E +L+  + E 
Sbjct: 1442 KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV---RADAETRLAEVQREA 1498

Query: 424  QLIRESLKVALQKHS-EEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERY 482
            Q     L+V   K+   +VK  EER               Q+  E+ ++   ++E LE +
Sbjct: 1499 QSTARELEVMTAKYEGAKVKVLEER---------------QRFQEERQKLTAQVEQLEVF 1543

Query: 483  LADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREA 542
              +    +  ++ S++L DS+  S   Q+K+  +++   E+Q   +  + QL        
Sbjct: 1544 QRE--QTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQL-------- 1593

Query: 543  EFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQ 602
                  + LQ + S +E + E  +++ME  +  YD+       ++Q+  +L+ Q++SLEQ
Sbjct: 1594 ------NELQAQLSQKEQAAEHYKLQMEKAKTHYDA-------KKQQNQELQEQLRSLEQ 1640

Query: 603  EVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQA 656
               Q+E  ++ LR EA+R    LQQ     KE     + L  +  +L+  +  A
Sbjct: 1641 --LQKE--NKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHA 1690



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 71/351 (20%), Positives = 153/351 (43%), Gaps = 43/351 (12%)

Query: 344  IDKQRKHISQLEQKVRESELQ------VHSALLGRPAPFGDVCLLRLQELQRENTFLRAQ 397
            +++ R+ + QL++++ + E +        S   GR  P G     +L+ L+ E + L  Q
Sbjct: 1080 LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGP----KLEALRAEVSKLEQQ 1135

Query: 398  FAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINN 457
              ++ E     +  LE +  AS  E     E+L+  L++ ++E+   +  +    + +  
Sbjct: 1136 CQKQQEQADSLERSLEAE-RASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAA 1194

Query: 458  LKKKCQKESEQNREKQQRI----ETLERYLADLPTLEDH-----------QKQSQQLK-- 500
             + K Q  S+   E + ++    +  ER  + + +LE+            + +S++LK  
Sbjct: 1195 FRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRL 1254

Query: 501  ---DSELKSTELQEKVTELESLLEETQAICREKEIQL----ESLRQREAEFSSAGHSLQD 553
               +SE KS +L+E++  L++      A   E+   L    +SLR+   +   A  +L+ 
Sbjct: 1255 VMAESE-KSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQ 1313

Query: 554  KQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSL-------EQEVAQ 606
            + + +    E    E+++WQ+++   ++ +   Q +    ++ V  L       +Q  A+
Sbjct: 1314 ELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAE 1373

Query: 607  EEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 657
            +    +  REE ++   A   LR  +     +  +LI     + E  R AQ
Sbjct: 1374 QAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ 1424



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 70/332 (21%), Positives = 137/332 (41%), Gaps = 17/332 (5%)

Query: 353  QLEQKVRESELQVHS--ALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKI 410
            Q EQ +   +L+  S  AL+    P   +C    Q+LQ E      +  ++ E   +   
Sbjct: 1338 QKEQALSTLQLEHTSTQALVSELLPAKHLC----QQLQAEQAAAEKRHREELEQSKQAAG 1393

Query: 411  DLEKKLSASEVEV-QLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQN 469
             L  +L  ++ E+ +LI    KVA Q+ + +  + E+      + ++ LKK     +E+N
Sbjct: 1394 GLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYA--EQLSMLKKAHGLLAEEN 1451

Query: 470  REKQQRIETLERYLADLPTLEDHQKQSQQLK----DSELKSTELQEKVTELESLLEETQA 525
            R   +R   L R   ++   +  +K  Q+L     D+E +  E+Q +       LE   A
Sbjct: 1452 RGLGERAN-LGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTA 1510

Query: 526  ICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEK 585
                 ++++   RQR   F      L  +    E        ++E   K+     +  + 
Sbjct: 1511 KYEGAKVKVLEERQR---FQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKV 1567

Query: 586  QQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEK 645
            QQQK+  +++Q    +QE  + +     L+ +  +++ A +  +  +++         ++
Sbjct: 1568 QQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQ 1627

Query: 646  NLTLQEHLRQAQPGSPPSPDTAQLALELHQEL 677
            N  LQE LR  +     + +    A  L  EL
Sbjct: 1628 NQELQEQLRSLEQLQKENKELRAEAERLGHEL 1659



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 39/168 (23%), Positives = 80/168 (47%), Gaps = 14/168 (8%)

Query: 495 QSQQLKDSELKSTELQEKVT--ELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQ 552
           Q+ Q +   LK     E+    ELE  L E + +  EK+ Q+  ++QR    +     L 
Sbjct: 210 QTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA----LLN 265

Query: 553 DKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQ 612
           +KQ+      +    E+E  + + +SL   + +  ++   L+++   +++++ Q    + 
Sbjct: 266 EKQAASPLEPK----ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENG 321

Query: 613 ALREEAQRRDSALQQLRTAVKELSVQN----QDLIEKNLTLQEHLRQA 656
            L  + +   S LQQL+ A+ EL+ ++    Q+ +EK   L++ L  A
Sbjct: 322 DLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAA 369


>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
          Length = 1088

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 103/477 (21%), Positives = 209/477 (43%), Gaps = 80/477 (16%)

Query: 337 LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLR------------- 383
           L+E EL I+ Q++ ++  ++ +++    + S  L   A   D    R             
Sbjct: 288 LEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLE 347

Query: 384 --LQELQRENTFLRAQF---------AQKTEALSR------EKID-LEKKLSASEVEVQL 425
             L++ ++EN+ LR +          + KT+AL         KI  +E+ L   E E+Q+
Sbjct: 348 SLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQM 407

Query: 426 IRESLKVALQKHSEEVKKQE---ERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERY 482
           ++ +  ++ ++  EE+K+ E      K     I  +K++  ++  +    Q ++ETL   
Sbjct: 408 LKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQ 467

Query: 483 LADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREA 542
            +D     +  K+S   K  E ++  LQ +V  L   LEE + +  +K  Q++ + + + 
Sbjct: 468 FSDSKQHIEVLKESLTAK--EQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKG 525

Query: 543 EFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQS--- 599
             +   H L+D   V+E        ++   QK+ ++LQ+ +  ++++M  L+ +V+S   
Sbjct: 526 TQAGEIHDLKDMLDVKER-------KVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQA 578

Query: 600 -----------LEQEVAQEEGTSQALREEAQRRDSALQQ--------LRTAVKELSVQNQ 640
                      LE+ +A++E T + L+E+  R +   Q+        L+   +++S+   
Sbjct: 579 DTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQG 638

Query: 641 DLIEKN---LTLQEHLRQ-AQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQ 696
           DL EK    L L+EH    A  G         L + L Q+   CL+       + +Q  +
Sbjct: 639 DLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLK-------MESQLKK 691

Query: 697 GHDPNLSLLLGIHSA---QHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDR 750
            H+  L        +   QH E ++   K +  K +  EV +L   ++++    +D+
Sbjct: 692 AHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ-AEVDRLLEILKEVENEKNDK 747



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 99/417 (23%), Positives = 192/417 (46%), Gaps = 57/417 (13%)

Query: 277 REQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILN-SNEH 335
           RE+  E+   ++ L+ ++   E++ L  G +    A+    L + E A  ++      + 
Sbjct: 613 REKQEEIDNYKKDLKDLK---EKVSLLQGDLSEKEASL---LDLKEHASSLASSGLKKDS 666

Query: 336 LLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAP-FGDVCLLRLQELQRENTFL 394
            LK  E+ ++++++   ++E +++++     +AL  R +P   D    R+Q L+RE T  
Sbjct: 667 RLKTLEIALEQKKEECLKMESQLKKAH---EAALEARASPEMSD----RIQHLEREITRY 719

Query: 395 RAQFAQKTEALSR----------EKIDLEKKLSASEVEVQLIRESLKVALQKHSEEV--K 442
           + + ++    + R          EK D +KK++  E+E Q+  ++ KVA  KH E+V  K
Sbjct: 720 KDESSKAQAEVDRLLEILKEVENEKNDKDKKIA--ELERQVKDQNKKVANLKHKEQVEKK 777

Query: 443 KQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDS 502
           K  + ++   +  +NL    Q+  +  R+K  RIE LE  L +  +++   ++   L   
Sbjct: 778 KSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRE--SVQITAEREMVLAQE 835

Query: 503 ELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQS-VEETS 561
           E   T  +++V EL   +E+ +        +LES++   A+ SS   SL +K++ +    
Sbjct: 836 ESARTNAEKQVEELLMAMEKVKQ-------ELESMK---AKLSSTQQSLAEKETHLTNLR 885

Query: 562 GEGPEVEMESWQKRYDSLQKIVEKQQQKMD--QLRSQVQSLEQEVAQEEGTSQALREEAQ 619
            E  +   E  + + ++L   + ++   +   +L S  +  ++EVA       AL+ E  
Sbjct: 886 AERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVA-------ALKRE-- 936

Query: 620 RRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPD-TAQLALELHQ 675
            +D  +QQL+   +       D  E +     H  Q      PSPD   Q  LEL Q
Sbjct: 937 -KDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQT--NHKPSPDQIIQPLLELDQ 990



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 106/477 (22%), Positives = 200/477 (41%), Gaps = 76/477 (15%)

Query: 337 LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRA 396
           L+EKE +++K+ K I  + ++      ++H           DV   ++  LQ++   L+ 
Sbjct: 503 LEEKETMLNKKTKQIQDMAEEKGTQAGEIHDL-----KDMLDVKERKVNVLQKKIENLQE 557

Query: 397 QFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVAL---QKHSEEVKKQEER-VKGRD 452
           Q   K + +S  K +  K L A          +L+ AL   ++  E +K+Q +R  + + 
Sbjct: 558 QLRDKEKQMSSLK-ERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQ 616

Query: 453 KHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEK 512
           + I+N KK  +   E+    Q  +   E  L DL         S   KDS LK+      
Sbjct: 617 EEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKT------ 670

Query: 513 VTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVE--------ETSGEG 564
              LE  LE+ +  C + E QL+   +   E  ++       Q +E        E+S   
Sbjct: 671 ---LEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ 727

Query: 565 PEVEM------ESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEA 618
            EV+       E   ++ D  +KI E ++Q  DQ   +V +L+ +   E+  S  + EEA
Sbjct: 728 AEVDRLLEILKEVENEKNDKDKKIAELERQVKDQ-NKKVANLKHKEQVEKKKSAQMLEEA 786

Query: 619 QRRDSAL----QQLRTAVKELSVQNQDLIEK-----NLTLQEHLRQAQPGSPPSPDTAQL 669
           +RR+  L    QQL+ ++++   + ++L E       +T +  +  AQ  S  +    Q+
Sbjct: 787 RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQV 846

Query: 670 ALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQ--HPETQLDLQKPDVI- 726
             EL   +    Q+L+++ + ++   Q      + L  + + +  H E  L++++  ++ 
Sbjct: 847 E-ELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLA 905

Query: 727 -----------------KRKLEE------------VQQLRRDIEDLRTTMSDRYAQD 754
                            K+K +E            VQQL++  ++    M+D Y  D
Sbjct: 906 AISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDD 962



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 83/396 (20%), Positives = 163/396 (41%), Gaps = 37/396 (9%)

Query: 389 RENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERV 448
           R+NT +  Q  Q  E L RE   L K +   E ++     S+K      S E+KK+    
Sbjct: 147 RDNTIMDLQ-TQLKEVL-RENDLLRKDVEVKESKLSSSMNSIKTFW---SPELKKERALR 201

Query: 449 KGRDKHINNLKKKCQKESEQNREKQQRIETLE---RYLADLPTL--EDHQKQSQQLKDSE 503
           K     I   K++ +   E+N+  Q  I+ L+   R   DL  L  +D   ++ +   +E
Sbjct: 202 KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAE 261

Query: 504 LKSTELQEKVTELESLLEE---TQAICREKEIQLESLRQ----REAEFSSAGHSLQDKQS 556
           L     Q    E E   +E    +    E E+++E+ +Q    R+         LQ K  
Sbjct: 262 LTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGL 321

Query: 557 VEETSGEGPE--VEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQAL 614
             + + E  E    +   +     L+ ++E+++++   LR ++     E A +   ++AL
Sbjct: 322 SAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHR-RFENAPDSAKTKAL 380

Query: 615 REEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTL-----QEHLRQAQPGSPPSPDTAQL 669
           +   + +DS +  +   +++L  + Q +++ N  L     +E ++Q +     S      
Sbjct: 381 QTVIEMKDSKISSMERGLRDLEEEIQ-MLKSNGALSTEEREEEMKQMEVYRSHSKFMKNK 439

Query: 670 ALELHQELA---SCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVI 726
             ++ QEL+   + L  LQ     +T +      ++ +L    +A+     +   + D +
Sbjct: 440 IGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDAL 499

Query: 727 KRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ 762
           + +LEE        ++       +  QDM E   TQ
Sbjct: 500 RLRLEE--------KETMLNKKTKQIQDMAEEKGTQ 527


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 87/389 (22%), Positives = 167/389 (42%), Gaps = 44/389 (11%)

Query: 274 WHPREQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISI--LN 331
           W  + Q  E    R+Q E IR Q E+M+ Q                  E   W     + 
Sbjct: 373 WEEKIQEQE-EKIREQEEKIREQEEKMRRQ------------------EEMMWEKEEKMR 413

Query: 332 SNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQREN 391
             E ++ EKE  + +Q + + + E+K+RE E ++H     R            ++ Q E 
Sbjct: 414 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE---------EKRQEEE 464

Query: 392 TFLRAQFAQKTEAL---SREKIDLEKKLSASEVEVQLIRESLKVALQ-KHSEEVKKQEER 447
                +  Q+ EA      EKI  E++    E E ++ R+  K+  Q K  EE K+QE+ 
Sbjct: 465 KIREQEKRQEQEAKMWRQEEKIR-EQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQE 523

Query: 448 VKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKST 507
              R +     +++  ++ E+  E++++I   E         E   +Q +++ D E K  
Sbjct: 524 EMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE---------EKMWRQEEKMHDQEEKIR 574

Query: 508 ELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEV 567
           E +EKV   E  + E +   RE+E ++    +   E        ++K   +E   +  E 
Sbjct: 575 EQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE 634

Query: 568 EMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQ 627
           +M   +++    +K + +Q++K+ +    +Q  E+++ ++E       E+ Q ++  +++
Sbjct: 635 KMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 694

Query: 628 LRTAVKELSVQNQDLIEKNLTLQEHLRQA 656
               + E  V+ +   EK    QEHL  A
Sbjct: 695 QEEKMWEQEVRLRQQEEKMQEHQEHLEAA 723



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 71/335 (21%), Positives = 161/335 (48%), Gaps = 37/335 (11%)

Query: 337 LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRA 396
           L+EK  L++ ++   S+++  V+E + ++  A L          LL  Q+LQ E   L  
Sbjct: 287 LQEKLQLVESEK---SEIQLNVKELKRKLERAKL----------LLPQQQLQAEADHLGK 333

Query: 397 QFAQKTEALSR--EKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKH 454
           +    +  L    E+ +L  +L+  + E ++ R+  K+  Q+  E++++QEE+++ +++ 
Sbjct: 334 ELQSVSAKLQAQVEENELWNRLNQQQEE-KMWRQEEKI--QEWEEKIQEQEEKIREQEEK 390

Query: 455 INNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVT 514
           I   ++K +++ E   EK++++   E  + +    E  ++Q + + + E K  EL+EK+ 
Sbjct: 391 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE--EKMRRQEEMMWEKEEKIRELEEKMH 448

Query: 515 ELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESW-- 572
           E E + E+      EK  + E +R++E          + ++ + E   +  E E + W  
Sbjct: 449 EQEKIREQ-----EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ 503

Query: 573 QKRYDSLQKI--VEKQQQKMDQLRSQVQSLEQE--------VAQEEGTSQALREEAQRRD 622
           +++    +KI   EK+Q++ +  R + +  EQE        + ++E   +   E+  R++
Sbjct: 504 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQE 563

Query: 623 SALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 657
             +      ++E   +     EK    +E +R+ +
Sbjct: 564 EKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQE 598


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 66/322 (20%), Positives = 163/322 (50%), Gaps = 22/322 (6%)

Query: 337 LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRA 396
           L+EK  L++ ++  I QL  K  + +L+    LL +     +   L  +ELQ  +  L+A
Sbjct: 214 LQEKLQLVESEKSEI-QLNVKELKRKLERAKLLLPQQQLQAEADHLG-KELQSVSAKLQA 271

Query: 397 QFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHIN 456
           Q  ++ E  +R     E+K+   E ++Q   E +    Q+  E++++QEE+++ +++ + 
Sbjct: 272 Q-VEENELWNRLNQQQEEKMWRQEEKIQEREEKI----QEQEEKIREQEEKMRRQEEMMW 326

Query: 457 NLKKKCQKESEQNREKQQRIETLERYLADLPTL---EDHQKQSQQLKDSELKSTELQEKV 513
             ++K +++ E   EK+++I  LE  + +   +   E+ +++ +++++ E K  E + K+
Sbjct: 327 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE-KRQEQEAKM 385

Query: 514 TELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQ 573
              E  + E +   RE+E  ++   ++  E        ++K   +E   +  E +M   +
Sbjct: 386 WRQEEKIREQEEKIREQEEMMQEQEEKMGE-------QEEKMWEQEEEMQEQEEKMRRQE 438

Query: 574 KRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEG----TSQALREEAQRRDSALQQLR 629
           ++    +K + +Q++K+ +    +Q  E+++ ++EG        ++E+ ++     +++R
Sbjct: 439 EKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIR 498

Query: 630 TAVKELSVQNQDLIEKNLTLQE 651
              K++  Q + + E+   +QE
Sbjct: 499 EQEKKIREQEEKIREQEEMMQE 520



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 75/377 (19%), Positives = 166/377 (44%), Gaps = 53/377 (14%)

Query: 287 RQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQ------WISILNSNEHLLKEK 340
           +++LE  +L + Q QLQ  A   H      S+     AQ      W  +    E  +  +
Sbjct: 236 KRKLERAKLLLPQQQLQ--AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ 293

Query: 341 ELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQ 400
           E  I ++ + I + E+K+RE E ++                      Q E  + + +  +
Sbjct: 294 EEKIQEREEKIQEQEEKIREQEEKMRR--------------------QEEMMWEKEEKMR 333

Query: 401 KTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKK 460
           + E +  EK +  ++L     E + IRE          EE +++EE+++ ++K     + 
Sbjct: 334 RQEEMMWEKEEKIRELEEKMHEQEKIREQ---------EEKRQEEEKIREQEKR-QEQEA 383

Query: 461 KCQKESEQNREKQQRIETLERYLADLPTLEDHQK-----QSQQLKDSELKSTELQEKVTE 515
           K  ++ E+ RE++++I   E  + +       Q+     Q +++++ E K    +EK+ E
Sbjct: 384 KMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIRE 443

Query: 516 LESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKR 575
            E  + E +   RE+E  ++   ++  E        + K   +E   +  E +M   +++
Sbjct: 444 QEKKIREQEEKIREQEEMMQEQEEKMGE-------QEGKMCEQEAKMQEQEEKMRRQEEK 496

Query: 576 YDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKEL 635
               +K + +Q++K+ +    +Q  E+++ ++E       E+ Q ++  +++    ++E 
Sbjct: 497 IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQ 556

Query: 636 SVQNQDLIEKNLTLQEH 652
            V+ +   EK   +QEH
Sbjct: 557 EVRLRQQEEK---MQEH 570


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
           sapiens]
          Length = 1116

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 87/396 (21%), Positives = 174/396 (43%), Gaps = 47/396 (11%)

Query: 384 LQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKK 443
           L++L+ E   L++  A  TE    E   +E   S S+     + E LK  L     + ++
Sbjct: 398 LRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKV-EQLKEELSSKEAQWEE 456

Query: 444 QEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSE 503
            +++  G    I  +K++  ++  +    Q ++ETL    +D     +  K+S   K  E
Sbjct: 457 LKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK--E 514

Query: 504 LKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGE 563
            ++  LQ +V  L   LEE + +  +K  Q++ + + +   +   H L+D   V+E    
Sbjct: 515 QRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKER--- 571

Query: 564 GPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQS--------------LEQEVAQEEG 609
               ++   QK+ ++LQ+ +  ++++M  L+ +V+S              LE+ +A++E 
Sbjct: 572 ----KVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKER 627

Query: 610 TSQALREEAQRRDSALQQ--------LRTAVKELSVQNQDLIEKN---LTLQEHLRQ-AQ 657
           T + L+E+  R +   Q+        L+   +++S+   DL EK    L L+EH    A 
Sbjct: 628 TIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLAS 687

Query: 658 PGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSA---QHP 714
            G         L + L Q+   CL+       + +Q  + H+  L        +   QH 
Sbjct: 688 SGLKKDSRLKTLEIALEQKKEECLK-------MESQLKKAHEAALEARASPEMSDRIQHL 740

Query: 715 ETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDR 750
           E ++   K +  K +  EV +L   ++++    +D+
Sbjct: 741 EREITRYKDESSKAQ-AEVDRLLEILKEVENEKNDK 775



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 99/417 (23%), Positives = 192/417 (46%), Gaps = 57/417 (13%)

Query: 277  REQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILN-SNEH 335
            RE+  E+   ++ L+ ++   E++ L  G +    A+    L + E A  ++      + 
Sbjct: 641  REKQEEIDNYKKDLKDLK---EKVSLLQGDLSEKEASL---LDLKEHASSLASSGLKKDS 694

Query: 336  LLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAP-FGDVCLLRLQELQRENTFL 394
             LK  E+ ++++++   ++E +++++     +AL  R +P   D    R+Q L+RE T  
Sbjct: 695  RLKTLEIALEQKKEECLKMESQLKKAH---EAALEARASPEMSD----RIQHLEREITRY 747

Query: 395  RAQFAQKTEALSR----------EKIDLEKKLSASEVEVQLIRESLKVALQKHSEEV--K 442
            + + ++    + R          EK D +KK++  E+E Q+  ++ KVA  KH E+V  K
Sbjct: 748  KDESSKAQAEVDRLLEILKEVENEKNDKDKKIA--ELERQVKDQNKKVANLKHKEQVEKK 805

Query: 443  KQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDS 502
            K  + ++   +  +NL    Q+  +  R+K  RIE LE  L +  +++   ++   L   
Sbjct: 806  KSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRE--SVQITAEREMVLAQE 863

Query: 503  ELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQS-VEETS 561
            E   T  +++V EL   +E+ +        +LES++   A+ SS   SL +K++ +    
Sbjct: 864  ESARTNAEKQVEELLMAMEKVKQ-------ELESMK---AKLSSTQQSLAEKETHLTNLR 913

Query: 562  GEGPEVEMESWQKRYDSLQKIVEKQQQKMD--QLRSQVQSLEQEVAQEEGTSQALREEAQ 619
             E  +   E  + + ++L   + ++   +   +L S  +  ++EVA       AL+ E  
Sbjct: 914  AERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVA-------ALKRE-- 964

Query: 620  RRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPD-TAQLALELHQ 675
             +D  +QQL+   +       D  E +     H  Q      PSPD   Q  LEL Q
Sbjct: 965  -KDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQT--NHKPSPDQIIQPLLELDQ 1018



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 106/477 (22%), Positives = 200/477 (41%), Gaps = 76/477 (15%)

Query: 337 LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRA 396
           L+EKE +++K+ K I  + ++      ++H           DV   ++  LQ++   L+ 
Sbjct: 531 LEEKETMLNKKTKQIQDMAEEKGTQAGEIHDL-----KDMLDVKERKVNVLQKKIENLQE 585

Query: 397 QFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVAL---QKHSEEVKKQEER-VKGRD 452
           Q   K + +S  K +  K L A          +L+ AL   ++  E +K+Q +R  + + 
Sbjct: 586 QLRDKEKQMSSLK-ERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQ 644

Query: 453 KHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEK 512
           + I+N KK  +   E+    Q  +   E  L DL         S   KDS LK+      
Sbjct: 645 EEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKT------ 698

Query: 513 VTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVE--------ETSGEG 564
              LE  LE+ +  C + E QL+   +   E  ++       Q +E        E+S   
Sbjct: 699 ---LEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ 755

Query: 565 PEVEM------ESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEA 618
            EV+       E   ++ D  +KI E ++Q  DQ   +V +L+ +   E+  S  + EEA
Sbjct: 756 AEVDRLLEILKEVENEKNDKDKKIAELERQVKDQ-NKKVANLKHKEQVEKKKSAQMLEEA 814

Query: 619 QRRDSAL----QQLRTAVKELSVQNQDLIEK-----NLTLQEHLRQAQPGSPPSPDTAQL 669
           +RR+  L    QQL+ ++++   + ++L E       +T +  +  AQ  S  +    Q+
Sbjct: 815 RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQV 874

Query: 670 ALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQ--HPETQLDLQKPDVI- 726
             EL   +    Q+L+++ + ++   Q      + L  + + +  H E  L++++  ++ 
Sbjct: 875 E-ELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLA 933

Query: 727 -----------------KRKLEE------------VQQLRRDIEDLRTTMSDRYAQD 754
                            K+K +E            VQQL++  ++    M+D Y  D
Sbjct: 934 AISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDD 990



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 70/410 (17%), Positives = 165/410 (40%), Gaps = 41/410 (10%)

Query: 383 RLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIR--ESLKVALQKHSEE 440
           +L+E+ REN  LR     K   LS     ++   S    + + +R  E+ K+ + K    
Sbjct: 157 QLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYR 216

Query: 441 VKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLE------DHQK 494
           V ++E +           + + Q++  Q  ++     T E  +A+L          +H++
Sbjct: 217 VVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHER 276

Query: 495 QSQQL-------KDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQ---REAEF 544
           Q+++L       ++ EL+    ++ +   +  +++   + + K +  ++  +   R    
Sbjct: 277 QAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRL 336

Query: 545 SSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDS---------LQKIVEKQQQKMDQLRS 595
           + A   +   +S+ E   +   +  E   +R+++         LQ ++E +  K+  +  
Sbjct: 337 AEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMER 396

Query: 596 QVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQ---EH 652
            ++ LE+E+   +       EE +     ++  R+  K +  + + L E+  + +   E 
Sbjct: 397 GLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEE 456

Query: 653 LRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQ 712
           L++   G     +  Q+  EL ++    L  LQ     +T +      ++ +L    +A+
Sbjct: 457 LKKKAAGL--QAEIGQVKQELSRKDTELLA-LQTKLETLTNQFSDSKQHIEVLKESLTAK 513

Query: 713 HPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ 762
                +   + D ++ +LEE        ++       +  QDM E   TQ
Sbjct: 514 EQRAAILQTEVDALRLRLEE--------KETMLNKKTKQIQDMAEEKGTQ 555


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
           sapiens]
          Length = 1843

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 88/357 (24%), Positives = 159/357 (44%), Gaps = 43/357 (12%)

Query: 331 NSNEHLLKEK-------ELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLR 383
           N ++ L+KEK       E L +   + I  LEQ+  E   Q  S+L  R     +    R
Sbjct: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQE-NEHLNQTVSSLRQRSQISAEA---R 581

Query: 384 LQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKK 443
           ++++++EN  L     + +  LS  KI+ EK+    E+E    +      L+     ++K
Sbjct: 582 VKDIEKENKILHESIKETSSKLS--KIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639

Query: 444 QEERVKGRDKHINNLKKKCQK-------ESEQNREKQQRIETLERYLADLPTLEDHQKQS 496
           + E ++   K I NLK  C+K        SE  RE ++  +TL+ +      LE  +K++
Sbjct: 640 ENELLQ---KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN 696

Query: 497 QQLKDSEL--------------KSTELQEKVTELESLLEETQAICREKEIQLESLRQREA 542
            QL +  L              K  +LQ +  ELES  E+ +      +   +   + E 
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEV 756

Query: 543 EFSSAGHSLQDKQSVEETSG---EGPEVEMESWQKRYDSLQKIVEK---QQQKMDQLRSQ 596
            +       Q  Q   E S    +  E E++  +    +LQK +E+     ++++QL  +
Sbjct: 757 SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816

Query: 597 VQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHL 653
            +SLEQE +Q E   + L +E +R     +   T ++E +V+  +L ++N TL + +
Sbjct: 817 NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 110/520 (21%), Positives = 220/520 (42%), Gaps = 75/520 (14%)

Query: 278  EQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPA-----------QW 326
            E++ EL    + L+   ++M Q+QL+N  +          L +L+ +           Q 
Sbjct: 701  EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760

Query: 327  ISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQE 386
            + I   N+ L K     ++   K I QLE ++++ E++  +  L +      +   RL++
Sbjct: 761  LDI--ENQRLQKT----LENSNKKIQQLESELQDLEME--NQTLQKNLEELKISSKRLEQ 812

Query: 387  LQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEE 446
            L++EN  L     Q+T  L ++K  LEK+      + ++        L++++ ++   E+
Sbjct: 813  LEKENKSLE----QETSQLEKDKKQLEKENKRLRQQAEI----KDTTLEENNVKIGNLEK 864

Query: 447  RVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQ-----KQSQQLKD 501
              K   K I   K+ C +  E  +E ++ ++     +  L TL +       K  Q   D
Sbjct: 865  ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND 924

Query: 502  SELKSTELQEKVTELESLLEETQAICREK----EIQLESLRQREAEFSSAGHSLQDKQSV 557
             E  + EL++     E LL + Q+    +    E +LES  ++  E      +  + +  
Sbjct: 925  LEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLE 984

Query: 558  EETS-GEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALRE 616
            E T+  +    E+++ +K Y++L++  ++++          +  + E   +E T + L+ 
Sbjct: 985  ESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKV 1044

Query: 617  -----EAQRRDSALQQ----LRTAVKELSVQNQDLI--------------EKNLTLQEHL 653
                 E +R ++ LQ     L+T +K+L  QN +L               E+N TLQ   
Sbjct: 1045 KDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN 1104

Query: 654  RQAQ--------PGSPPSPDTAQLALE---LHQELASCLQDLQAVCSIVTQRAQGHDPNL 702
             + Q          +      AQL ++   L  E  S +++ + + S+     + H+  L
Sbjct: 1105 AKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE-KL 1163

Query: 703  SLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIED 742
             LL   H  Q  E +  + K   +K   + ++   RD+ED
Sbjct: 1164 ELL---HERQASEYESLISKHGTLKSAHKNLEVEHRDLED 1200



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 111/566 (19%), Positives = 240/566 (42%), Gaps = 90/566 (15%)

Query: 236 ERNG----PHSNSSGVLPLGLQPAPGLSKP-----LPSQVWQPSPDTWHPR----EQSCE 282
           ER+G    PH++SS   P G   +PG+ +      L  ++          R    E++ +
Sbjct: 217 ERDGLHFLPHASSSAQSPCG---SPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQ 273

Query: 283 LSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKEL 342
           L  C+Q+LE + ++++++Q +N             + +L  A+   +       L+EK +
Sbjct: 274 LLDCKQELEQMEIELKRLQQEN-------------MNLLSDARSARMYRDELDALREKAV 320

Query: 343 LIDKQRKHISQLEQ--------KVRESELQVHSALLGRPAPFGDVCLL-------RLQEL 387
            +DK    +S+ ++        K R  EL+  + +L       +  L        +L EL
Sbjct: 321 RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHEL 380

Query: 388 QRENTFLRAQF--AQKTEALSREKID--LEKKLSASEVEVQLIRESLKVA--LQKHSEEV 441
           ++EN  L+A+    +    + R+KI+  +E+ ++    + Q + ESL +   L++ S   
Sbjct: 381 EKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTS 440

Query: 442 KKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDH-------QK 494
           +  E   K     +N L      + E   E Q   +T+E     + ++E +       +K
Sbjct: 441 ELSEAPQKSLGHEVNELTSSRLLKLEM--ENQSLTKTVEELRTTVDSVEGNASKILKMEK 498

Query: 495 QSQQL-KDSELKSTELQEKVTELESLLEETQAICREK---EIQLESLRQREAE-----FS 545
           ++Q+L K  E+   E+ ++   L++    ++ + +EK   E  +E+LR+           
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558

Query: 546 SAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVA 605
              H  Q   S+ + S    E  ++  +K    L + +++   K+ ++  + + +++E+ 
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL- 617

Query: 606 QEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPD 665
                 +  +E+ +R +    +L    KE  +  + +    +T ++     Q  S    +
Sbjct: 618 ------EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671

Query: 666 TAQL--ALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHS---AQHPETQLDL 720
             +L   L+  + L   L+ L+       + +Q  + NL L   + S   A     QL L
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLE------KENSQLDEENLELRRNVESLKCASMKMAQLQL 725

Query: 721 QKPDVIKRKLEEVQQLRRDIEDLRTT 746
           +  ++   K    +QL++ +E L+ +
Sbjct: 726 ENKELESEK----EQLKKGLELLKAS 747



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 77/348 (22%), Positives = 159/348 (45%), Gaps = 13/348 (3%)

Query: 340 KELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFA 399
           K L ++K+ + +S+ + ++ E+E+      L          +    +L++    LR    
Sbjct: 492 KILKMEKENQRLSK-KVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550

Query: 400 QKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLK 459
           ++ + L +E   L + +S+     Q+  E+    ++K ++ + +  +    +   I   K
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEK 610

Query: 460 KKCQKESEQNREKQQRIETLERYLADLPTLEDH-QKQSQQLKDSELKSTELQEKVTELES 518
           ++ +KE E  +EK +R E LE  L  L    +  QK+   LK +  K   L+++ +ELE 
Sbjct: 611 RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELER 670

Query: 519 ---LLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKR 575
               L++T    +    QLESL +  ++      +L+ +++VE  S +   ++M   Q  
Sbjct: 671 ENRKLKKTLDSFKNLTFQLESLEKENSQLDE--ENLELRRNVE--SLKCASMKMAQLQLE 726

Query: 576 YDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKEL 635
              L+   E+ ++ ++ L++  +  E+     E + Q L  E QR    L+     +++L
Sbjct: 727 NKELESEKEQLKKGLELLKASFKKTERL----EVSYQGLDIENQRLQKTLENSNKKIQQL 782

Query: 636 SVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQD 683
             + QDL  +N TLQ++L + +  S       +    L QE +   +D
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD 830



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 61/348 (17%), Positives = 155/348 (44%), Gaps = 48/348 (13%)

Query: 332  SNEHLLKEKELLIDKQRKHIS-QLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRE 390
            +   LLK K+ LI+ +R + + Q E++  +++L+                     +L+ +
Sbjct: 1037 TTRELLKVKDRLIEVERNNATLQAEKQALKTQLK---------------------QLETQ 1075

Query: 391  NTFLRAQFAQKTEALSREKIDLEKK---LSASEVEVQLIRESLK---VALQKHSEEVKKQ 444
            N  L+AQ      AL R+ + L+++   L     ++Q+   +L     +L   + ++  Q
Sbjct: 1076 NNNLQAQIL----ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ 1131

Query: 445  EERVKGRDKHINNLKKKCQKESEQNREKQQRIETL-ERYLADLPTL-EDHQKQSQQLKDS 502
            +  ++  ++ +   ++  +   +   +  +++E L ER  ++  +L   H       K+ 
Sbjct: 1132 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL 1191

Query: 503  ELKSTELQEKVTEL---ESLLEETQAICR-EKEIQLESLRQREAEFSSAGHSLQDKQSVE 558
            E++  +L+++  +L   +  LE+ + + + E+E  L   +  E   +       +   + 
Sbjct: 1192 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN 1251

Query: 559  ETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEA 618
             T  +  + E E  Q  + +L+ ++   + +  +L ++   L+++  Q + TS  L  + 
Sbjct: 1252 HTYSQLLK-ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQC 1310

Query: 619  Q-------RRDSALQQLRTAVKELSVQNQDLIEKNLTLQE--HLRQAQ 657
            +         +   + L   ++ L +QN+ L+E+N+  ++  H+ Q Q
Sbjct: 1311 ELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQ 1358


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
           sapiens]
          Length = 1870

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 88/357 (24%), Positives = 159/357 (44%), Gaps = 43/357 (12%)

Query: 331 NSNEHLLKEK-------ELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLR 383
           N ++ L+KEK       E L +   + I  LEQ+  E   Q  S+L  R     +    R
Sbjct: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQE-NEHLNQTVSSLRQRSQISAEA---R 581

Query: 384 LQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKK 443
           ++++++EN  L     + +  LS  KI+ EK+    E+E    +      L+     ++K
Sbjct: 582 VKDIEKENKILHESIKETSSKLS--KIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639

Query: 444 QEERVKGRDKHINNLKKKCQK-------ESEQNREKQQRIETLERYLADLPTLEDHQKQS 496
           + E ++   K I NLK  C+K        SE  RE ++  +TL+ +      LE  +K++
Sbjct: 640 ENELLQ---KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN 696

Query: 497 QQLKDSEL--------------KSTELQEKVTELESLLEETQAICREKEIQLESLRQREA 542
            QL +  L              K  +LQ +  ELES  E+ +      +   +   + E 
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEV 756

Query: 543 EFSSAGHSLQDKQSVEETSG---EGPEVEMESWQKRYDSLQKIVEK---QQQKMDQLRSQ 596
            +       Q  Q   E S    +  E E++  +    +LQK +E+     ++++QL  +
Sbjct: 757 SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816

Query: 597 VQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHL 653
            +SLEQE +Q E   + L +E +R     +   T ++E +V+  +L ++N TL + +
Sbjct: 817 NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 110/519 (21%), Positives = 220/519 (42%), Gaps = 74/519 (14%)

Query: 278  EQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPA-----------QW 326
            E++ EL    + L+   ++M Q+QL+N  +          L +L+ +           Q 
Sbjct: 701  EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760

Query: 327  ISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQE 386
            + I   N+ L K     ++   K I QLE ++++ E++  +  L +      +   RL++
Sbjct: 761  LDI--ENQRLQKT----LENSNKKIQQLESELQDLEME--NQTLQKNLEELKISSKRLEQ 812

Query: 387  LQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEE 446
            L++EN  L     Q+T  L ++K  LEK+      + ++        L++++ ++   E+
Sbjct: 813  LEKENKSLE----QETSQLEKDKKQLEKENKRLRQQAEI----KDTTLEENNVKIGNLEK 864

Query: 447  RVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQ-----KQSQQLKD 501
              K   K I   K+ C +  E  +E ++ ++     +  L TL +       K  Q   D
Sbjct: 865  ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND 924

Query: 502  SELKSTELQEKVTELESLLEETQAI---CREKEIQLESLRQREAEFSSAGHSLQDKQSVE 558
             E  + EL++     E LL + Q+     +  E +LES  ++  E      +  + +  E
Sbjct: 925  LEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEE 984

Query: 559  ETS-GEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALRE- 616
             T+  +    E+++ +K Y++L++  ++++          +  + E   +E T + L+  
Sbjct: 985  STNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK 1044

Query: 617  ----EAQRRDSALQQ----LRTAVKELSVQNQDLI--------------EKNLTLQEHLR 654
                E +R ++ LQ     L+T +K+L  QN +L               E+N TLQ    
Sbjct: 1045 DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA 1104

Query: 655  QAQ--------PGSPPSPDTAQLALE---LHQELASCLQDLQAVCSIVTQRAQGHDPNLS 703
            + Q          +      AQL ++   L  E  S +++ + + S+     + H+  L 
Sbjct: 1105 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE-KLE 1163

Query: 704  LLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIED 742
            LL   H  Q  E +  + K   +K   + ++   RD+ED
Sbjct: 1164 LL---HERQASEYESLISKHGTLKSAHKNLEVEHRDLED 1199



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 111/566 (19%), Positives = 240/566 (42%), Gaps = 90/566 (15%)

Query: 236 ERNG----PHSNSSGVLPLGLQPAPGLSKP-----LPSQVWQPSPDTWHPR----EQSCE 282
           ER+G    PH++SS   P G   +PG+ +      L  ++          R    E++ +
Sbjct: 217 ERDGLHFLPHASSSAQSPCG---SPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQ 273

Query: 283 LSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKEL 342
           L  C+Q+LE + ++++++Q +N             + +L  A+   +       L+EK +
Sbjct: 274 LLDCKQELEQMEIELKRLQQEN-------------MNLLSDARSARMYRDELDALREKAV 320

Query: 343 LIDKQRKHISQLEQ--------KVRESELQVHSALLGRPAPFGDVCLL-------RLQEL 387
            +DK    +S+ ++        K R  EL+  + +L       +  L        +L EL
Sbjct: 321 RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHEL 380

Query: 388 QRENTFLRAQF--AQKTEALSREKID--LEKKLSASEVEVQLIRESLKVA--LQKHSEEV 441
           ++EN  L+A+    +    + R+KI+  +E+ ++    + Q + ESL +   L++ S   
Sbjct: 381 EKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTS 440

Query: 442 KKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDH-------QK 494
           +  E   K     +N L      + E   E Q   +T+E     + ++E +       +K
Sbjct: 441 ELSEAPQKSLGHEVNELTSSRLLKLEM--ENQSLTKTVEELRTTVDSVEGNASKILKMEK 498

Query: 495 QSQQL-KDSELKSTELQEKVTELESLLEETQAICREK---EIQLESLRQREAE-----FS 545
           ++Q+L K  E+   E+ ++   L++    ++ + +EK   E  +E+LR+           
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558

Query: 546 SAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVA 605
              H  Q   S+ + S    E  ++  +K    L + +++   K+ ++  + + +++E+ 
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL- 617

Query: 606 QEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPD 665
                 +  +E+ +R +    +L    KE  +  + +    +T ++     Q  S    +
Sbjct: 618 ------EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671

Query: 666 TAQL--ALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHS---AQHPETQLDL 720
             +L   L+  + L   L+ L+       + +Q  + NL L   + S   A     QL L
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLE------KENSQLDEENLELRRNVESLKCASMKMAQLQL 725

Query: 721 QKPDVIKRKLEEVQQLRRDIEDLRTT 746
           +  ++   K    +QL++ +E L+ +
Sbjct: 726 ENKELESEK----EQLKKGLELLKAS 747



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 77/348 (22%), Positives = 159/348 (45%), Gaps = 13/348 (3%)

Query: 340 KELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFA 399
           K L ++K+ + +S+ + ++ E+E+      L          +    +L++    LR    
Sbjct: 492 KILKMEKENQRLSK-KVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550

Query: 400 QKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLK 459
           ++ + L +E   L + +S+     Q+  E+    ++K ++ + +  +    +   I   K
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEK 610

Query: 460 KKCQKESEQNREKQQRIETLERYLADLPTLEDH-QKQSQQLKDSELKSTELQEKVTELES 518
           ++ +KE E  +EK +R E LE  L  L    +  QK+   LK +  K   L+++ +ELE 
Sbjct: 611 RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELER 670

Query: 519 ---LLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKR 575
               L++T    +    QLESL +  ++      +L+ +++VE  S +   ++M   Q  
Sbjct: 671 ENRKLKKTLDSFKNLTFQLESLEKENSQLDE--ENLELRRNVE--SLKCASMKMAQLQLE 726

Query: 576 YDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKEL 635
              L+   E+ ++ ++ L++  +  E+     E + Q L  E QR    L+     +++L
Sbjct: 727 NKELESEKEQLKKGLELLKASFKKTERL----EVSYQGLDIENQRLQKTLENSNKKIQQL 782

Query: 636 SVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQD 683
             + QDL  +N TLQ++L + +  S       +    L QE +   +D
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD 830



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 61/348 (17%), Positives = 155/348 (44%), Gaps = 48/348 (13%)

Query: 332  SNEHLLKEKELLIDKQRKHIS-QLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRE 390
            +   LLK K+ LI+ +R + + Q E++  +++L+                     +L+ +
Sbjct: 1036 TTRELLKVKDRLIEVERNNATLQAEKQALKTQLK---------------------QLETQ 1074

Query: 391  NTFLRAQFAQKTEALSREKIDLEKK---LSASEVEVQLIRESLK---VALQKHSEEVKKQ 444
            N  L+AQ      AL R+ + L+++   L     ++Q+   +L     +L   + ++  Q
Sbjct: 1075 NNNLQAQIL----ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ 1130

Query: 445  EERVKGRDKHINNLKKKCQKESEQNREKQQRIETL-ERYLADLPTL-EDHQKQSQQLKDS 502
            +  ++  ++ +   ++  +   +   +  +++E L ER  ++  +L   H       K+ 
Sbjct: 1131 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL 1190

Query: 503  ELKSTELQEKVTEL---ESLLEETQAICR-EKEIQLESLRQREAEFSSAGHSLQDKQSVE 558
            E++  +L+++  +L   +  LE+ + + + E+E  L   +  E   +       +   + 
Sbjct: 1191 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN 1250

Query: 559  ETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEA 618
             T  +  + E E  Q  + +L+ ++   + +  +L ++   L+++  Q + TS  L  + 
Sbjct: 1251 HTYSQLLK-ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQC 1309

Query: 619  Q-------RRDSALQQLRTAVKELSVQNQDLIEKNLTLQE--HLRQAQ 657
            +         +   + L   ++ L +QN+ L+E+N+  ++  H+ Q Q
Sbjct: 1310 ELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQ 1357


>gi|50658069 phosphodiesterase 4D interacting protein isoform 2
           [Homo sapiens]
          Length = 969

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 103/432 (23%), Positives = 182/432 (42%), Gaps = 39/432 (9%)

Query: 321 LEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPA-----P 375
           ++P Q+   L   +  ++E    +  Q + + QL    RE +  +H  LL  P      P
Sbjct: 159 VKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLS---REKQQLLH--LLEEPTSMEVQP 213

Query: 376 FGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQ 435
             +  LL+ Q+L    T +  Q    +        +L++K+  +E   ++++E L     
Sbjct: 214 MTEE-LLKQQKLNSHETTITQQSVSDSHLA-----ELQEKIQQTEATNKILQEKLN---- 263

Query: 436 KHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQ 495
           + S E+K  +E  + +D  I NLK+  +    +  E  Q IE     +A L  +  HQ Q
Sbjct: 264 EMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREML-HQSQ 322

Query: 496 SQQLKDSELKSTELQE-KVTELESLLEETQAICREKEIQL--ESLRQREAEFSSAGHSLQ 552
             QL  SE  S   Q+  + +L+S L      C + EIQ     +RQ+E + + A   +Q
Sbjct: 323 LGQLHSSEGTSPAQQQVALLDLQSAL-----FCSQLEIQKLQRVVRQKERQLADAKQCVQ 377

Query: 553 DKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQ 612
             ++    S +  E   +  Q+   +LQ++ E+ Q K  QLR+       E+  +E   Q
Sbjct: 378 FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ 437

Query: 613 ALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALE 672
            L      ++  LQ+ R  ++     ++ L E N  L E LRQ         D A     
Sbjct: 438 HLNHSLSHKEQLLQEFRELLQYRDNSDKTL-EANEMLLEKLRQR------IHDKAVALER 490

Query: 673 LHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEE 732
              E  S L++ +     +    +  D +L  L  + S+     Q       +++ K  E
Sbjct: 491 AIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQ---SMESLLRAKGLE 547

Query: 733 VQQLRRDIEDLR 744
           V+QL    ++L+
Sbjct: 548 VEQLSTTCQNLQ 559



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 92/434 (21%), Positives = 180/434 (41%), Gaps = 46/434 (10%)

Query: 330 LNSNEHLLKEKELLIDKQRKHISQLEQKVRESEL-QVHSALLGRPAPFGDVCLLRLQELQ 388
           L S E   +E   +I+ Q   +++L + + +S+L Q+HS+    PA    V LL LQ   
Sbjct: 290 LKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQ-QQVALLDLQSA- 347

Query: 389 RENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERV 448
               F      QK + + R+K   E++L+ ++  VQ +  +       H  E +K+    
Sbjct: 348 ---LFCSQLEIQKLQRVVRQK---ERQLADAKQCVQFVEAAA------HESEQQKEASW- 394

Query: 449 KGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTE 508
               KH   L+K  Q+  E+ + K Q++   E             ++  +++  E     
Sbjct: 395 ----KHNQELRKALQQLQEELQNKSQQLRAWEA------------EKYNEIRTQEQNIQH 438

Query: 509 LQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVE 568
           L   ++  E LL+E + + + ++   ++L   E         + DK    E + +     
Sbjct: 439 LNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSA 498

Query: 569 MESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQL 628
           +E  +K    L+  V ++   +++LR  + S E  +   E   +A   E ++  +  Q L
Sbjct: 499 LEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNL 558

Query: 629 RTAVKELSV------QNQDLIEKNLTLQEHLRQAQPGSPPS-------PDTAQLALELHQ 675
           +   +E+        + Q+ I + L    H R  +     +       P  +++A EL Q
Sbjct: 559 QWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQ 618

Query: 676 ELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQK-PDVIKRKLEEVQ 734
            L    + LQ + S   ++   H+  +  LL   S +  E+Q   +K    +  +  E+Q
Sbjct: 619 RLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQ 678

Query: 735 QLRRDIEDLRTTMS 748
            LR+ +    + MS
Sbjct: 679 ALRQYLGGRDSLMS 692



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 89/425 (20%), Positives = 184/425 (43%), Gaps = 67/425 (15%)

Query: 384 LQELQREN-------TFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQ- 435
           L +L++EN        FL  +  QK EA SRE  D+ K+    +VEV+ ++  L+   Q 
Sbjct: 12  LNDLKKENFSLKLRIYFLEERMQQKYEA-SRE--DIYKRNIELKVEVESLKRELQDKKQH 68

Query: 436 -------------KHSEEVKKQEERVKGRDKHINNLKKK----CQKESEQNREKQQRIET 478
                        ++  E+++Q E  +   +H+  L +      Q+ES   + +  R+  
Sbjct: 69  LDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAA 128

Query: 479 L-----ERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQ 533
           L     E  L     L+   K  + +   ++K  +  E + + +  +EE       +E  
Sbjct: 129 LVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERL 188

Query: 534 LESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQ------- 586
           +E L + + +     H L++  S+E      P  E    Q++ +S +  + +Q       
Sbjct: 189 VEQLSREKQQLL---HLLEEPTSMEVQ----PMTEELLKQQKLNSHETTITQQSVSDSHL 241

Query: 587 ---QQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLI 643
              Q+K+ Q  +  + L++++ +     +  +E +Q++D  +Q L+  +K    + ++L 
Sbjct: 242 AELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELY 301

Query: 644 E----KNLT---LQEHLRQAQPG-----SPPSPDTAQLALELHQELASCLQ-DLQAVCSI 690
           +    +N T   L+E L Q+Q G        SP   Q+AL   Q    C Q ++Q +  +
Sbjct: 302 QVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRV 361

Query: 691 VTQRAQGHDPNLSLLLGIHSAQHPETQ---LDLQKPDVIKRKLEEVQ-QLRRDIEDLRTT 746
           V Q+ +        +  + +A H   Q      +    +++ L+++Q +L+   + LR  
Sbjct: 362 VRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAW 421

Query: 747 MSDRY 751
            +++Y
Sbjct: 422 EAEKY 426



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 82/369 (22%), Positives = 150/369 (40%), Gaps = 44/369 (11%)

Query: 338 KEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPF-GDVCLLRLQELQRENTFLRA 396
           KE+E +I + +  +    ++V +    + + LL +  P   ++     Q LQR+   L+ 
Sbjct: 574 KEQESIIQQLQTSLHDRNKEVED----LSATLLCKLGPGQSEIAEELCQRLQRKERMLQD 629

Query: 397 QFAQKTEALSREKIDLE---KKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDK 453
             + + + +   +++++   + +S  E E Q   E L  AL + + E++   + + GRD 
Sbjct: 630 LLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDS 689

Query: 454 HINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTEL--QE 511
            ++                Q  I   +  +     L     Q      S   ST L  +E
Sbjct: 690 LMS----------------QAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKE 733

Query: 512 KVTELESLLEETQAICR-EKEI-----QLESLRQREAEFSSAGHSLQDKQSVEETSGEGP 565
            V+   S L +   +   EKE+     +LE + ++E E      +LQ   +V+E   +  
Sbjct: 734 DVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQ 793

Query: 566 EVEMESWQKRYDSLQKIVEKQQQK---------MDQLRSQVQSLEQEVAQEEGTSQALRE 616
             +MES  +     + +++  Q +         M++L  +V  L ++VA  E   Q +  
Sbjct: 794 AADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEI-- 851

Query: 617 EAQRRDSALQQLRTAVKELSVQNQDL-IEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQ 675
              RR   L  L   V E S  N+ L  E+ L        A P S     T Q+ LE  Q
Sbjct: 852 SGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQ 911

Query: 676 ELASCLQDL 684
            L S L+++
Sbjct: 912 VLRSRLEEV 920


>gi|157311604 phosphodiesterase 4D interacting protein isoform 1
           [Homo sapiens]
          Length = 2346

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 103/432 (23%), Positives = 182/432 (42%), Gaps = 39/432 (9%)

Query: 321 LEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPA-----P 375
           ++P Q+   L   +  ++E    +  Q + + QL    RE +  +H  LL  P      P
Sbjct: 159 VKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLS---REKQQLLH--LLEEPTSMEVQP 213

Query: 376 FGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQ 435
             +  LL+ Q+L    T +  Q    +        +L++K+  +E   ++++E L     
Sbjct: 214 MTEE-LLKQQKLNSHETTITQQSVSDSHLA-----ELQEKIQQTEATNKILQEKLN---- 263

Query: 436 KHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQ 495
           + S E+K  +E  + +D  I NLK+  +    +  E  Q IE     +A L  +  HQ Q
Sbjct: 264 EMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREML-HQSQ 322

Query: 496 SQQLKDSELKSTELQE-KVTELESLLEETQAICREKEIQL--ESLRQREAEFSSAGHSLQ 552
             QL  SE  S   Q+  + +L+S L      C + EIQ     +RQ+E + + A   +Q
Sbjct: 323 LGQLHSSEGTSPAQQQVALLDLQSAL-----FCSQLEIQKLQRVVRQKERQLADAKQCVQ 377

Query: 553 DKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQ 612
             ++    S +  E   +  Q+   +LQ++ E+ Q K  QLR+       E+  +E   Q
Sbjct: 378 FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ 437

Query: 613 ALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALE 672
            L      ++  LQ+ R  ++     ++ L E N  L E LRQ         D A     
Sbjct: 438 HLNHSLSHKEQLLQEFRELLQYRDNSDKTL-EANEMLLEKLRQR------IHDKAVALER 490

Query: 673 LHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEE 732
              E  S L++ +     +    +  D +L  L  + S+     Q       +++ K  E
Sbjct: 491 AIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQ---SMESLLRAKGLE 547

Query: 733 VQQLRRDIEDLR 744
           V+QL    ++L+
Sbjct: 548 VEQLSTTCQNLQ 559



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 92/434 (21%), Positives = 180/434 (41%), Gaps = 46/434 (10%)

Query: 330 LNSNEHLLKEKELLIDKQRKHISQLEQKVRESEL-QVHSALLGRPAPFGDVCLLRLQELQ 388
           L S E   +E   +I+ Q   +++L + + +S+L Q+HS+    PA    V LL LQ   
Sbjct: 290 LKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQ-QQVALLDLQSA- 347

Query: 389 RENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERV 448
               F      QK + + R+K   E++L+ ++  VQ +  +       H  E +K+    
Sbjct: 348 ---LFCSQLEIQKLQRVVRQK---ERQLADAKQCVQFVEAAA------HESEQQKEASW- 394

Query: 449 KGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTE 508
               KH   L+K  Q+  E+ + K Q++   E             ++  +++  E     
Sbjct: 395 ----KHNQELRKALQQLQEELQNKSQQLRAWEA------------EKYNEIRTQEQNIQH 438

Query: 509 LQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVE 568
           L   ++  E LL+E + + + ++   ++L   E         + DK    E + +     
Sbjct: 439 LNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSA 498

Query: 569 MESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQL 628
           +E  +K    L+  V ++   +++LR  + S E  +   E   +A   E ++  +  Q L
Sbjct: 499 LEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNL 558

Query: 629 RTAVKELSV------QNQDLIEKNLTLQEHLRQAQPGSPPS-------PDTAQLALELHQ 675
           +   +E+        + Q+ I + L    H R  +     +       P  +++A EL Q
Sbjct: 559 QWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQ 618

Query: 676 ELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQK-PDVIKRKLEEVQ 734
            L    + LQ + S   ++   H+  +  LL   S +  E+Q   +K    +  +  E+Q
Sbjct: 619 RLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQ 678

Query: 735 QLRRDIEDLRTTMS 748
            LR+ +    + MS
Sbjct: 679 ALRQYLGGRDSLMS 692



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 89/425 (20%), Positives = 184/425 (43%), Gaps = 67/425 (15%)

Query: 384 LQELQREN-------TFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQ- 435
           L +L++EN        FL  +  QK EA SRE  D+ K+    +VEV+ ++  L+   Q 
Sbjct: 12  LNDLKKENFSLKLRIYFLEERMQQKYEA-SRE--DIYKRNIELKVEVESLKRELQDKKQH 68

Query: 436 -------------KHSEEVKKQEERVKGRDKHINNLKKK----CQKESEQNREKQQRIET 478
                        ++  E+++Q E  +   +H+  L +      Q+ES   + +  R+  
Sbjct: 69  LDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAA 128

Query: 479 L-----ERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQ 533
           L     E  L     L+   K  + +   ++K  +  E + + +  +EE       +E  
Sbjct: 129 LVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERL 188

Query: 534 LESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQ------- 586
           +E L + + +     H L++  S+E      P  E    Q++ +S +  + +Q       
Sbjct: 189 VEQLSREKQQLL---HLLEEPTSMEVQ----PMTEELLKQQKLNSHETTITQQSVSDSHL 241

Query: 587 ---QQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLI 643
              Q+K+ Q  +  + L++++ +     +  +E +Q++D  +Q L+  +K    + ++L 
Sbjct: 242 AELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELY 301

Query: 644 E----KNLT---LQEHLRQAQPG-----SPPSPDTAQLALELHQELASCLQ-DLQAVCSI 690
           +    +N T   L+E L Q+Q G        SP   Q+AL   Q    C Q ++Q +  +
Sbjct: 302 QVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRV 361

Query: 691 VTQRAQGHDPNLSLLLGIHSAQHPETQ---LDLQKPDVIKRKLEEVQ-QLRRDIEDLRTT 746
           V Q+ +        +  + +A H   Q      +    +++ L+++Q +L+   + LR  
Sbjct: 362 VRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAW 421

Query: 747 MSDRY 751
            +++Y
Sbjct: 422 EAEKY 426



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 82/369 (22%), Positives = 150/369 (40%), Gaps = 44/369 (11%)

Query: 338 KEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPF-GDVCLLRLQELQRENTFLRA 396
           KE+E +I + +  +    ++V +    + + LL +  P   ++     Q LQR+   L+ 
Sbjct: 574 KEQESIIQQLQTSLHDRNKEVED----LSATLLCKLGPGQSEIAEELCQRLQRKERMLQD 629

Query: 397 QFAQKTEALSREKIDLE---KKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDK 453
             + + + +   +++++   + +S  E E Q   E L  AL + + E++   + + GRD 
Sbjct: 630 LLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDS 689

Query: 454 HINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTEL--QE 511
            ++                Q  I   +  +     L     Q      S   ST L  +E
Sbjct: 690 LMS----------------QAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKE 733

Query: 512 KVTELESLLEETQAICR-EKEI-----QLESLRQREAEFSSAGHSLQDKQSVEETSGEGP 565
            V+   S L +   +   EKE+     +LE + ++E E      +LQ   +V+E   +  
Sbjct: 734 DVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQ 793

Query: 566 EVEMESWQKRYDSLQKIVEKQQQK---------MDQLRSQVQSLEQEVAQEEGTSQALRE 616
             +MES  +     + +++  Q +         M++L  +V  L ++VA  E   Q +  
Sbjct: 794 AADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEI-- 851

Query: 617 EAQRRDSALQQLRTAVKELSVQNQDL-IEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQ 675
              RR   L  L   V E S  N+ L  E+ L        A P S     T Q+ LE  Q
Sbjct: 852 SGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQ 911

Query: 676 ELASCLQDL 684
            L S L+++
Sbjct: 912 VLRSRLEEV 920



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 47/187 (25%), Positives = 89/187 (47%), Gaps = 18/187 (9%)

Query: 385  QELQRENTFLRAQFAQKTEAL------SREKI-DLEKKLSASEVEVQLIRESLKVALQKH 437
            + LQ + + +  + +Q+TE+L      SR  + +LEK+L   +VE Q + E L+   +K 
Sbjct: 1912 RRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLR---EKQ 1968

Query: 438  SEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQ 497
             E +  +EER+  ++   + L+ K     +Q  EKQQ  E+L+  L     L  + K+  
Sbjct: 1969 QEVLHFREERLSLQEND-SRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKG- 2026

Query: 498  QLKDSELKSTELQEKVTELESLLEETQAICREKEIQLES-----LRQREAEFSSAGHSLQ 552
             LK   L +       ++L  L+ E +A+  + E  ++      L+ ++   S AG +  
Sbjct: 2027 -LKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASL 2085

Query: 553  DKQSVEE 559
               S+ +
Sbjct: 2086 SPSSINQ 2092



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 89/420 (21%), Positives = 169/420 (40%), Gaps = 65/420 (15%)

Query: 335  HLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLR--LQELQRENT 392
            HL  E    ++++RK     E++++E + Q+  A       F  V  +R  +  L  EN 
Sbjct: 1008 HLRAEFHQHLEEKRK----AEEELKELKAQIEEA------GFSSVSHIRNTMLSLCLENA 1057

Query: 393  FLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRD 452
             L+ Q     EA+S +  ++E+     EV V+ +     ++      E +K + ++K   
Sbjct: 1058 ELKEQMG---EAMS-DGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAH 1113

Query: 453  KHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEK 512
              IN LK++    S++   K              P L  H   + +  ++EL  +  + +
Sbjct: 1114 NIINLLKEQLVLSSKEGNSKLT------------PELLVHLTSTIERINTELVGSPGKHQ 1161

Query: 513  VTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESW 572
              E  ++    +   R + + L       A F+   H L D QS  +    GP+      
Sbjct: 1162 HQEEGNVT--VRPFPRPQSLDLG------ATFTVDAHQL-DNQS--QPRDPGPQSAF--- 1207

Query: 573  QKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSAL---QQLR 629
                 SL    +  + ++ Q + + Q L++++   E T  A   E ++    L     ++
Sbjct: 1208 -----SLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVK 1262

Query: 630  TAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCS 689
               K++ V  QDL  +     E+  +A+     SP+      E H  L   +  ++ +CS
Sbjct: 1263 QDSKQIQVDLQDLGYETCGRSEN--EAEREETTSPEC-----EEHNSLKEMVL-MEGLCS 1314

Query: 690  IVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSD 749
               +R        S L      +  E QL  Q+   +  K E +  LR+DI+DL+  + +
Sbjct: 1315 EQGRRG-------STLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQN 1367



 Score = 30.4 bits (67), Expect = 6.4
 Identities = 42/236 (17%), Positives = 91/236 (38%), Gaps = 23/236 (9%)

Query: 468  QNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTEL----------- 516
            Q   K    + LE +L ++  L    ++S  + D   +  +L+ ++T             
Sbjct: 1833 QLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLRE--QLEHRLTSTARGRGSTSNFY 1890

Query: 517  ESLLEETQAICREKEIQLESLRQREAEFSSAG-------HSLQDKQSVEETSGEGPEVEM 569
               LE    +C E  +  E  R+ +A+ S           SL++      +  +  E E+
Sbjct: 1891 SQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKEL 1950

Query: 570  ESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLR 629
            E  +     L + + ++QQ++   R +  SL++  ++ +     L+++ + +    + L+
Sbjct: 1951 EHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQ 2010

Query: 630  TAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQ 685
            +   EL +           L+ +   A    P S D + L  E+        Q +Q
Sbjct: 2011 S---ELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQ 2063


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 68/320 (21%), Positives = 155/320 (48%), Gaps = 16/320 (5%)

Query: 330 LNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQR 389
           +   E  ++E+E  + +Q   + + E +VRE E QV           G V     Q  ++
Sbjct: 124 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 183

Query: 390 ENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESL---KVALQKHSEEVKKQEE 446
           E   +R Q  Q  E    +  + E+++   E ++Q   E +   +  ++K  E++ +QEE
Sbjct: 184 EGQ-VREQEGQMGEQ-EGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEE 241

Query: 447 RVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKS 506
           +V+ +++ +   +++ +K+ EQ RE+++++   E  +      ++  +Q +Q  + E + 
Sbjct: 242 QVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQ---KEQTEQEEQTGEQEEQM 298

Query: 507 TELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSV---EETSGE 563
            E +E++ E E  + E +   RE+E Q+   +Q E  +       + K+ +   EE  GE
Sbjct: 299 REQEEQMREQEEQMREQEEQMREQEEQMG--KQEEQMWEQKEQMWEQKEQMWKQEEQMGE 356

Query: 564 GPEV---EMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQR 620
             E    + E  +K+ + ++K  E+ +++ +Q+R Q + + ++  Q     + +RE+ ++
Sbjct: 357 QEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQ 416

Query: 621 RDSALQQLRTAVKELSVQNQ 640
                +Q+R   + +  Q +
Sbjct: 417 MGEQKEQMRKQEEHMGEQKE 436



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 91/428 (21%), Positives = 193/428 (45%), Gaps = 45/428 (10%)

Query: 337 LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRA 396
           LKEK   + ++ + +     +  +SE+Q+H   L R      + L +  +++ +   +R 
Sbjct: 9   LKEKNAELQEELQLV-----ETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVRE 63

Query: 397 QFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHIN 456
           Q  Q  E   + +   E++    E E Q+  +  +V  Q+   +V++QE +V+ ++  + 
Sbjct: 64  QEGQVREQEGQVR---EQEGQVREQEGQVREQEGQVREQEG--QVREQEGQVREQEGQVR 118

Query: 457 NLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTEL 516
             + + +++  Q RE++ ++   E  +         ++Q  Q+++ E +  E + +V E 
Sbjct: 119 EQEGQVREQEGQVREQEGQVREQEGQV---------REQEGQVREQEGQVREQEGQVREQ 169

Query: 517 ESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRY 576
           E  + E +   RE+E Q+   R++E +       + ++   EE  GE  E +M+  +++ 
Sbjct: 170 EGQVREQEGQVREQEGQV---REQEGQMGEQEGQMGEQ---EEQMGEQEE-QMQKQEEQM 222

Query: 577 DSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEE-----GTSQALREEAQRRDSALQQLRTA 631
              ++ + KQ+++M +   QVQ  E++V ++E        Q   +E Q R+   Q L+  
Sbjct: 223 GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQ- 281

Query: 632 VKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIV 691
            KE + Q +   E+   ++E   Q +       +  +   E  +++    Q+ Q    + 
Sbjct: 282 -KEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGK--QEEQ----MW 334

Query: 692 TQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDRY 751
            Q+ Q  +    +       Q  E +  +QK +   RK EE  Q+R+  E +R       
Sbjct: 335 EQKEQMWEQKEQMWK--QEEQMGEQEEQMQKQEEQVRKQEE--QMRKQEEQMRKQEEQMR 390

Query: 752 AQD--MGE 757
            Q+  MGE
Sbjct: 391 KQEEQMGE 398



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 69/379 (18%), Positives = 172/379 (45%), Gaps = 42/379 (11%)

Query: 277 REQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHL 336
           +E++ EL   +++L+L+  +  ++QL    +          +P+ +  Q    +   E  
Sbjct: 10  KEKNAEL---QEELQLVETEKSEIQLHIKELKRKLET--DKIPLPQEGQ----VREQEGQ 60

Query: 337 LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRA 396
           ++E+E  + +Q   + + E +VRE E QV                 +  +++ +   +R 
Sbjct: 61  VREQEGQVREQEGQVREQEGQVREQEGQVRE---------------QEGQVREQEGQVRE 105

Query: 397 QFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHIN 456
           Q  Q  E   + +   E++    E E Q+  +  +V  ++   +V++QE +V+ ++  + 
Sbjct: 106 QEGQVREQEGQVR---EQEGQVREQEGQVREQEGQV--REQEGQVREQEGQVREQEGQVR 160

Query: 457 NLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTEL 516
             + + +++  Q RE++ ++   E  +         ++Q  Q+ + E +  E +E++ E 
Sbjct: 161 EQEGQVREQEGQVREQEGQVREQEGQV---------REQEGQMGEQEGQMGEQEEQMGEQ 211

Query: 517 ESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRY 576
           E  +++ +    E+E   E +R++E +       +Q ++   +   E    + E  +++ 
Sbjct: 212 EEQMQKQEEQMGEQE---EQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQE 268

Query: 577 DSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELS 636
           + +++  E+  ++ +Q   + Q+ EQE    E   Q   +E Q R+   +Q+R   +++ 
Sbjct: 269 EQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQE-EQMREQEEQMG 327

Query: 637 VQNQDLIEKNLTLQEHLRQ 655
            Q + + E+   + E   Q
Sbjct: 328 KQEEQMWEQKEQMWEQKEQ 346



 Score = 34.3 bits (77), Expect = 0.44
 Identities = 33/132 (25%), Positives = 65/132 (49%), Gaps = 10/132 (7%)

Query: 504 LKSTELQEKVTELESLLEETQAICREK-EIQLESLRQREAEFSSAGHSLQDKQSVEETSG 562
           + + EL+EK  EL+   EE Q +  EK EIQL  +++ + +  +    L  +  V E  G
Sbjct: 4   ITNEELKEKNAELQ---EELQLVETEKSEIQLH-IKELKRKLETDKIPLPQEGQVREQEG 59

Query: 563 EGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRD 622
              +V  +  Q R    Q  V +Q+ ++ +   QV+  E +V ++EG  +    + + ++
Sbjct: 60  ---QVREQEGQVREQEGQ--VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 114

Query: 623 SALQQLRTAVKE 634
             +++    V+E
Sbjct: 115 GQVREQEGQVRE 126


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 91/400 (22%), Positives = 175/400 (43%), Gaps = 61/400 (15%)

Query: 274 WHPREQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSN 333
           W  + Q  E    R+Q E IR Q E+M+ Q                  E   W       
Sbjct: 312 WEEKIQEQE-EKIREQEEKIREQEEKMRRQ------------------EEMMW----EKE 348

Query: 334 EHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTF 393
           E + +++E++ +K+ K + +LE+ + E E ++                  L+E   E   
Sbjct: 349 EKMRRQEEMMWEKEEK-MRRLEEMMWEKEEKIRE----------------LEEKMHEQEK 391

Query: 394 LRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKK---QEERVKG 450
           +R Q  ++ E    EKI  ++K    E ++    E ++   +K  E+ KK   QEE++  
Sbjct: 392 IREQEEKRQE---EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 448

Query: 451 RDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQK-------QSQQLKDSE 503
           ++K     K++ Q+E  +  EK +  E + R    +   E  +K       Q +++ D E
Sbjct: 449 QEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQE 508

Query: 504 LKSTELQEKVTELESLLEETQAICREKEIQL----ESLRQREAEFSSAGHSLQDKQSV-- 557
            K  E +EK+   E  + E +   RE+E ++    E ++++E +       +Q+++ +  
Sbjct: 509 EKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRR 568

Query: 558 -EETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALRE 616
            EE   E  E   E  +K  +  +KI E Q++K+ +    +Q  E+++ ++E       E
Sbjct: 569 QEEKIREQEEKIREQKEKIREQEEKIWE-QEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 627

Query: 617 EAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQA 656
           + Q ++  +++    + E  V+ +   EK    QEHL  A
Sbjct: 628 KMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 667



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 67/327 (20%), Positives = 160/327 (48%), Gaps = 29/327 (8%)

Query: 337 LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRA 396
           L+EK  L++ ++   S+++  V+E + ++  A L          LL  Q+LQ E   L  
Sbjct: 226 LQEKLQLVESEK---SEIQLNVKELKRKLERAKL----------LLPQQQLQAEADHLGK 272

Query: 397 QFAQKTEALSR--EKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKH 454
           +    +  L    E+ +L  +L+  + E ++ R+  K+  Q+  E++++QEE+++ +++ 
Sbjct: 273 ELQSVSAKLQAQVEENELWNRLNQQQEE-KMWRQEEKI--QEWEEKIQEQEEKIREQEEK 329

Query: 455 INNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVT 514
           I   ++K +++ E   EK++++   E  + +    E  ++  + + + E K  EL+EK+ 
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE--EKMRRLEEMMWEKEEKIRELEEKMH 387

Query: 515 ELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESW-- 572
           E E + E+      EK  + E +R++E          + ++ + E   +  E E + W  
Sbjct: 388 EQEKIREQ-----EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ 442

Query: 573 QKRYDSLQKI--VEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRT 630
           +++    +KI   EK+Q++ +  R + +  EQE    +      +E+ ++++  + +   
Sbjct: 443 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEE 502

Query: 631 AVKELSVQNQDLIEKNLTLQEHLRQAQ 657
            + +   + ++  EK    +E +R+ +
Sbjct: 503 KMHDQEEKIREQEEKMWRQEEKIREQE 529


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 102/456 (22%), Positives = 181/456 (39%), Gaps = 70/456 (15%)

Query: 223  PEAKKAPGSGAVFERNGPHSNSSGVL--PLGLQPAPGLSKPLPSQVWQPSPDTWHPREQS 280
            P  +  PGS A   R+ P   S   L  P  L+ +PG   P P     P+     P    
Sbjct: 1452 PAPRPVPGSPA---RDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVR 1508

Query: 281  CELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEK 340
              L    Q+L   + + ++++ Q  A+                             L E 
Sbjct: 1509 GALREFLQELRSAQRERDELRTQTSAL--------------------------NRQLAEM 1542

Query: 341  ELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRA---- 396
            E   D       QL++ V ESE +   ++ GR +       L+ + ++R     RA    
Sbjct: 1543 EAERDSATSRARQLQKAVAESE-EARRSVDGRLSGVQAELALQEESVRRSERERRATLDQ 1601

Query: 397  -----QFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGR 451
                 +  Q TE+  R   +   K+ A+E +++  +  LK  L        K E + +  
Sbjct: 1602 VATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSL 1661

Query: 452  DKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQE 511
            +  +   +        Q +  Q R+++L+R                Q+ DSE+K+  LQ 
Sbjct: 1662 EGELQRSRLGLSDREAQAQALQDRVDSLQR----------------QVADSEVKAGTLQL 1705

Query: 512  KVTELESLL---EETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVE 568
             V  L   L   EE++   R+K   +  L +  A+ S++ +S +DK    + +    E +
Sbjct: 1706 TVERLNGALAKVEESEGALRDK---VRGLTEALAQSSASLNSTRDKNLHLQKALTACEHD 1762

Query: 569  MESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVA-------QEEGTSQALREEAQRR 621
             +  Q+R D+ ++ + + +++   L  QVQ+L  EVA       + EG  Q LRE  ++R
Sbjct: 1763 RQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQR 1822

Query: 622  DSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 657
                      V++L  + + L E+  +LQ  L Q +
Sbjct: 1823 QEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLE 1858



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 89/386 (23%), Positives = 172/386 (44%), Gaps = 60/386 (15%)

Query: 381  LLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEE 440
            L  L+  QRE   LR Q    T AL+R+  ++E +  ++    + +++++       SEE
Sbjct: 1515 LQELRSAQRERDELRTQ----TSALNRQLAEMEAERDSATSRARQLQKAVA-----ESEE 1565

Query: 441  VKKQEE-RVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQL 499
             ++  + R+ G    +   ++  ++   + R    ++ TLER    L   E   + SQ+ 
Sbjct: 1566 ARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLER---SLQATESELRASQE- 1621

Query: 500  KDSELKS--TELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSV 557
            K S++K+  T+L+     L+ +L+ +++   + E+Q  SL   E E   +   L D+   
Sbjct: 1622 KISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSL---EGELQRSRLGLSDR--- 1675

Query: 558  EETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREE 617
                    E + ++ Q R DSLQ+ V   + K   L+  V+ L   +A+ E +  ALR++
Sbjct: 1676 --------EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDK 1727

Query: 618  AQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQEL 677
             +    AL Q   ++     +N  L +K LT  EH RQ         D A+ AL   ++ 
Sbjct: 1728 VRGLTEALAQSSASLNSTRDKNLHL-QKALTACEHDRQV---LQERLDAARQALSEARKQ 1783

Query: 678  ASCLQD----------------------LQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPE 715
            +S L +                      LQ +  ++ QR +G    L+ +  +      E
Sbjct: 1784 SSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD----E 1839

Query: 716  TQLDLQKPDVIKRKLEEVQQLRRDIE 741
             +L  ++   ++R L +++  +R++E
Sbjct: 1840 RRLLQERLGSLQRALAQLEAEKREVE 1865



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 134/619 (21%), Positives = 240/619 (38%), Gaps = 100/619 (16%)

Query: 172  RQEEARKFDIPSMESTLNQS------------AMMETLYSDPHHRVRFHNPRTSTSKELY 219
            R EEA   D  S  S LN+S            A +E   S    R R      + ++E  
Sbjct: 728  RAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQ 787

Query: 220  RVLPEAKKAPGSGAVFERNGPHSNSSGVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQ 279
              L E +         E+        G L +  Q    L + LP+   + S       + 
Sbjct: 788  ERLEELR--------LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQL 839

Query: 280  SCELSTCRQQLELIRLQ-------MEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNS 332
            S +LS   Q+LE  R +       +E+   +  A+    A     L   E  +  ++   
Sbjct: 840  SRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAE-REGRTLSEE 898

Query: 333  NEHLLKEKELL---IDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQR 389
               L  EKE L   + + ++ ++QLE +  + E +  + LL +    G++  LR Q +  
Sbjct: 899  ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIA- 957

Query: 390  ENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRE---SLKVALQKHSEEVKKQEE 446
                            ++EK  L+K+L A ++ VQ  RE   SL+     H E++++ + 
Sbjct: 958  ----------------TQEKASLDKELMAQKL-VQAEREAQASLREQRAAHEEDLQRLQ- 999

Query: 447  RVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKS 506
                                   REK+     LE   A L + +  ++Q + L   E + 
Sbjct: 1000 -----------------------REKEAAWRELEAERAQLQS-QLQREQEELLARLEAEK 1035

Query: 507  TELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPE 566
             EL E++  L+   +E   +   ++ Q  SL+  E+E ++    L   +    T     E
Sbjct: 1036 EELSEEIAALQQERDEGLLLAESEKQQALSLK--ESEKTALSEKLMGTRHSLATISLEME 1093

Query: 567  VEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQE-EGTSQALREEAQRRDSAL 625
             +    Q R +  +  V     ++  LR+Q +      AQE     +  R+  ++RDS L
Sbjct: 1094 RQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCL 1153

Query: 626  ---QQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQ 682
               ++LRT ++ L      L  + L  Q  LR++Q G        Q A EL + L    +
Sbjct: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQ---RQEAGELRRSLGEGAK 1210

Query: 683  DLQAVC----SIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDV------IKRKLEE 732
            + +A+      + +   +     +SL L     +     L+  +  V      ++  L+E
Sbjct: 1211 EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270

Query: 733  VQ----QLRRDIEDLRTTM 747
            V+    + RR++++LR  M
Sbjct: 1271 VERSRLEARRELQELRRQM 1289



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 95/406 (23%), Positives = 177/406 (43%), Gaps = 50/406 (12%)

Query: 287  RQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDK 346
            ++QL  +  + EQ++ +  A+          L  L       I+ + E    +KEL+  K
Sbjct: 917  QRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ----QIIATQEKASLDKELMAQK 972

Query: 347  ----QRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQ---ELQRENTFLRAQFA 399
                +R+  + L ++    E  +      + A + ++   R Q   +LQRE   L A+  
Sbjct: 973  LVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLE 1032

Query: 400  QKTEALSREKIDLEKK------LSASEVEVQL-IRESLKVALQKHSEEVKKQEERVKGRD 452
             + E LS E   L+++      L+ SE +  L ++ES K AL   SE++      +    
Sbjct: 1033 AEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTAL---SEKLMGTRHSLATIS 1089

Query: 453  KHINNLKKKCQKESEQNRE------------KQQRIETLERYLADLPTLEDHQKQSQQLK 500
              +   K+  Q   EQ+R             + QR E    +  ++  L++  +   + +
Sbjct: 1090 LEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQR 1149

Query: 501  DSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVE-- 558
            DS L+  E +E  T+L  L +    + RE    LE+  QR+   S  G  +Q +++ E  
Sbjct: 1150 DSCLR--EAEELRTQLRLLEDARDGLRREL---LEA--QRKLRESQEGREVQRQEAGELR 1202

Query: 559  ETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEA 618
             + GEG + E E+ ++  + L+  V+K + +   L+   +  EQ++A  E    A+ +EA
Sbjct: 1203 RSLGEGAK-EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEA 1261

Query: 619  QRRDSALQQL-------RTAVKELSVQNQDLIEKNLTLQEHLRQAQ 657
                + LQ++       R  ++EL  Q + L  +N  L   L + Q
Sbjct: 1262 GELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQ 1307



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 91/451 (20%), Positives = 177/451 (39%), Gaps = 54/451 (11%)

Query: 336  LLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLR 395
            LL+E    + K+   +    Q+V  S L+    L             +++ L  ENT L 
Sbjct: 1249 LLEEARTAVGKEAGELRTGLQEVERSRLEARREL--------QELRRQMKMLDSENTRLG 1300

Query: 396  AQFAQKTEALS----------REKIDLEKKLSASEVEVQLIRESLKVA---LQKHSEEVK 442
             + A+    L+          RE + L ++L   E  ++++R+ L+VA   LQ+   E +
Sbjct: 1301 RELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFR 1360

Query: 443  KQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDS 502
             +E R+ G  +     +K+   + +  R  + ++E      A+L       +   Q  ++
Sbjct: 1361 TRERRLLGSLEEARGTEKQ---QLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEA 1417

Query: 503  ELKSTELQEKVTE-----LESLLEETQAICREKEIQ---LESLRQREAEFSSAGHSLQDK 554
            EL   E+Q +  E     L S L     + R        +     R+A    +G  L   
Sbjct: 1418 ELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSP 1477

Query: 555  QSVE------------ETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQ 602
             ++E             TS   P+++ E+ +       + +   Q++ D+LR+Q  +L +
Sbjct: 1478 STLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNR 1537

Query: 603  EVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPP 662
            ++A+ E        E     S  +QL+ AV E     + +  +   +Q  L   +     
Sbjct: 1538 QLAEMEA-------ERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRR 1590

Query: 663  SPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQK 722
            S    +  L+    L   LQ  ++      ++      N + L G    +  +  LD  +
Sbjct: 1591 SERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEG--DKRRLKEVLDASE 1648

Query: 723  PDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQ 753
               +K +L+  + L  +++  R  +SDR AQ
Sbjct: 1649 SRTVKLELQR-RSLEGELQRSRLGLSDREAQ 1678



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 55/241 (22%), Positives = 110/241 (45%), Gaps = 39/241 (16%)

Query: 384 LQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKK 443
           L  LQ EN  L+ + ++  + L++ + + ++      ++   + E L+ AL+    E++ 
Sbjct: 76  LLSLQEENQLLQQELSRVEDLLAQSRAERDELA----IKYNAVSERLEQALRLEPGELET 131

Query: 444 QEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSE 503
           QE R  G  +    L+++ Q+E    R K Q  +            E  Q+Q+Q ++  +
Sbjct: 132 QEPR--GLVRQSVELRRQLQEEQASYRRKLQAYQ------------EGQQRQAQLVQRLQ 177

Query: 504 LKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGE 563
            K  + +++ +ELE  L E          +LE  R R+ E S      QD +S       
Sbjct: 178 GKILQYKKRCSELEQQLLERSG-------ELEQQRLRDTEHS------QDLESAL----- 219

Query: 564 GPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDS 623
              + +E  Q+R  SL ++    ++++DQ  S  Q+L +++ +        R+E + R++
Sbjct: 220 ---IRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREA 276

Query: 624 A 624
           A
Sbjct: 277 A 277



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 102/461 (22%), Positives = 178/461 (38%), Gaps = 57/461 (12%)

Query: 331  NSNEHLLKEKELLIDKQRKHISQLEQKVRESE-LQVHSALLGRPAPFGDVCLLRLQELQR 389
            ++NE L +EK  L    +    Q E+  +E E LQ     L R          RL+E Q 
Sbjct: 596  SANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRD-------RLEEEQE 648

Query: 390  ENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVA------LQKHSEEVKK 443
            +     A+  ++ E   R+   LE K S    E+  +RE+L  A      LQ    EV +
Sbjct: 649  DAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAE 708

Query: 444  QEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLAD--------LPTLEDHQKQ 495
               + +     +     K + E    ++   ++  L   LA         +  LE+ +  
Sbjct: 709  ALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSA 768

Query: 496  SQ-QLKDSELKSTELQEKVTELESLLEETQAI-------CREKEIQLESLRQREAEFSSA 547
             Q + + +E ++T  +E+   LE L  E +          R  E   E+L Q+       
Sbjct: 769  LQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHE 828

Query: 548  GHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQE 607
               LQ++ +       G E E+E  ++      + +E+  ++ + L  +   L  ++   
Sbjct: 829  RSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAA 888

Query: 608  EGTSQALREEAQRR--------------DSALQQLRTAVKELSVQNQDLIEKNLTLQEHL 653
            E   + L EEA R                  L QL    ++L  + Q L+    TL   L
Sbjct: 889  EREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL 948

Query: 654  RQAQPGSPPSPDTAQLALEL-HQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQ 712
               +     + + A L  EL  Q+L    ++ QA  S+  QRA  H+ +L  L     A 
Sbjct: 949  AGLRQQIIATQEKASLDKELMAQKLVQAEREAQA--SLREQRA-AHEEDLQRLQREKEAA 1005

Query: 713  HPE---------TQLDLQKPDVIKRKLEEVQQLRRDIEDLR 744
              E         +QL  ++ +++ R   E ++L  +I  L+
Sbjct: 1006 WRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQ 1046



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 55/255 (21%), Positives = 108/255 (42%), Gaps = 14/255 (5%)

Query: 497 QQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQR----EAEFSSAGHSLQ 552
           +QL DSE +   L+E++  L    +       + + +++ LR        E S+  HSLQ
Sbjct: 554 KQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQ 613

Query: 553 -DKQSVEETSGEGPEVE--MESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEG 609
             +Q  EE   E  +++   E  +++ D L++  E   Q   ++R +++   +++ Q EG
Sbjct: 614 VAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEG 673

Query: 610 TSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQL 669
               L +E       L ++R A+   ++Q   L  +   + E L +A+ G      +   
Sbjct: 674 KRSVLAKE-------LVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTK 726

Query: 670 ALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRK 729
                  L   L  L A+   + Q     +  ++ L    SA     +   Q+  V + +
Sbjct: 727 LRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREE 786

Query: 730 LEEVQQLRRDIEDLR 744
            E +++LR + E  R
Sbjct: 787 QERLEELRLEQEVAR 801



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 76/356 (21%), Positives = 150/356 (42%), Gaps = 53/356 (14%)

Query: 332 SNEHLLKEKELLIDKQ----RKHISQLEQKVRESELQVHSALLG-----RPAPFGDVCLL 382
           SNEH    + LL+ +Q    R+ +S+++       LQ+   L       + A  G    L
Sbjct: 290 SNEH---SRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGL 346

Query: 383 RLQELQRENTFLRAQFAQ-KTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEV 441
           RL E + E    +    Q + E   R+K+  EK L+  +++  L +  L   + +    V
Sbjct: 347 RLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAV 406

Query: 442 KKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKD 501
           K+ E++   +D+   +L +K +       ++Q  +ET           ED +   Q L+D
Sbjct: 407 KRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALET-----------EDGEGLQQTLRD 455

Query: 502 ---SELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVE 558
              + L  +E   +++  E   + +    R    Q      R    SS G     ++   
Sbjct: 456 LAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRR---SSPGRGRSPRRGPS 512

Query: 559 ETSGEGP------------EVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQ 606
               +              +++++  + RY++ Q ++   ++++    S+ ++LE+++ +
Sbjct: 513 PACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQR 572

Query: 607 ----EEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQ---EHLRQ 655
                +G  QA  E+AQR    +Q+LR+A + LS +  +L       Q   E LRQ
Sbjct: 573 LRDKTDGAMQA-HEDAQRE---VQRLRSANELLSREKSNLAHSLQVAQQQAEELRQ 624



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 29/144 (20%), Positives = 67/144 (46%), Gaps = 8/144 (5%)

Query: 330  LNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDV------CLLR 383
            L + +  ++   L ++K R  + +   KV   +L+ H   +   A  G +        L 
Sbjct: 1857 LEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELE 1916

Query: 384  LQELQRENTFLRAQFA--QKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEV 441
            L E QR+   L AQ    +++ + ++ ++D +++    + EV+ +R +     +      
Sbjct: 1917 LAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARE 1976

Query: 442  KKQEERVKGRDKHINNLKKKCQKE 465
            +   +RV+G ++ ++ LK + Q+E
Sbjct: 1977 RAHRQRVRGLEEQVSTLKGQLQQE 2000


>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 97/468 (20%), Positives = 208/468 (44%), Gaps = 52/468 (11%)

Query: 287 RQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPA-QWISILNSNEHLLKEKELLID 345
           RQQ+  ++ Q++Q+QL+   +     A    +  L+   QW         L +E  + + 
Sbjct: 537 RQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQW---YQQQLALAQEARVRLQ 593

Query: 346 KQRKHI--SQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTE 403
            +  HI   Q+ Q      L++ +  L +          +L E Q  +   + + A + +
Sbjct: 594 GEMAHIQVGQMTQAGLLEHLKLENVSLSQ----------QLTETQHRSMKEKGRIAAQLQ 643

Query: 404 ALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQ 463
            +  + +D E    A+ +++Q  +  ++  LQ+  EE + + ER++       +L+++ +
Sbjct: 644 GIEADMLDQE----AAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLE 699

Query: 464 KESEQNREKQQRIETLERYLADLP-----TLEDHQKQSQQLKDSELKSTELQEKVTELE- 517
           +      ++ Q++E L++   DL      T E  Q + Q L   +    ELQ ++ EL+ 
Sbjct: 700 QVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQG 759

Query: 518 --SLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKR 575
             +  E+T  + + ++I L      EA   +A    ++         EG E   E+ +K 
Sbjct: 760 EAASREDTICLLQNEKIIL------EAALQAAKSGKEELDRGARRLEEGTEETSETLEKL 813

Query: 576 YDSL---QKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAV 632
            + L      VE  QQ+   L+ Q+Q ++++  Q++   +A R +A  +D  + +L+   
Sbjct: 814 REELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATR 873

Query: 633 KELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVT 692
           K L  + ++L ++ + +    R A+         A+L+  LH+E+A   Q +  +   + 
Sbjct: 874 KRLDSELKELRQELMQVHGEKRTAE---------AELS-RLHREVAQVRQHMADLEGHLQ 923

Query: 693 QRAQGHDPNLSLLLGIHSAQHPETQL--DLQKPDVIKRKLEEVQQLRR 738
              +  D    +   + S Q  + Q+    +  + +K+++EE+QQ  R
Sbjct: 924 SAQKERD---EMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEAR 968



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 108/490 (22%), Positives = 194/490 (39%), Gaps = 91/490 (18%)

Query: 336  LLKEKELLIDKQRKHISQLEQKVRESE-LQVHSALLGRPAPFGDVCLLRLQELQRENTFL 394
            LL+  + L   Q++H+  ++Q     E LQ     L       D    RL ELQ E    
Sbjct: 705  LLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGE---- 760

Query: 395  RAQFAQKTEALSREKIDLEKKLSASEV---EVQLIRESLKVALQKHSEEVKKQEERV--- 448
             A        L  EKI LE  L A++    E+      L+   ++ SE ++K  E +   
Sbjct: 761  AASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIK 820

Query: 449  KGRDKHINN----LKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSEL 504
             G+ +H+      LKK+ QK  EQ  +++  +E   R       L    K +++  DSEL
Sbjct: 821  SGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSEL 880

Query: 505  KSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEG 564
            K  EL++++ ++       +A       ++  +RQ  A+      S Q ++   ET  + 
Sbjct: 881  K--ELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQS 938

Query: 565  PEVEMESW----------QKRYDSLQ----KIVEKQQQKMDQLRSQVQSLEQEVAQE--- 607
             + + E            +K+ + LQ    K + +Q+QKM +L S + S ++E+  +   
Sbjct: 939  LQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKA 998

Query: 608  -----------------------------------EGTSQALREEAQRRDSALQQLRTAV 632
                                                 +S AL E  Q  ++ LQ +  + 
Sbjct: 999  YENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSK 1058

Query: 633  KELSVQNQDLI-----------EKNLTLQEHLRQAQPGSPP----SPDTAQLALELHQEL 677
              L  + Q++I           EK L L++ L++++              +LALEL  E 
Sbjct: 1059 TLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEK 1118

Query: 678  ASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLR 737
                     +  +    A   + N  L   +   +    QL+LQ   V++RK EE +Q++
Sbjct: 1119 GK-------LTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMK 1171

Query: 738  RDIEDLRTTM 747
              ++ L+ ++
Sbjct: 1172 HLVQALQASL 1181



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 101/449 (22%), Positives = 193/449 (42%), Gaps = 68/449 (15%)

Query: 325  QWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSA----LLGRPAPFGDVC 380
            Q +++  +NE L K+ E L  + RK I++ +QK+R     + SA         A    V 
Sbjct: 945  QMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVG 1004

Query: 381  LL--RLQELQRENTFLRAQFAQ--KTEALSREKIDLEKKLSASEVEVQLIRESLKVALQK 436
            +L  RLQE         A+  Q       S   + L +++ A E E+Q +  S K  L+K
Sbjct: 1005 ILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHS-KTLLEK 1063

Query: 437  HSEEV--KKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQK 494
              +EV     +E  + R+K +     + + E +++R  +++I+ LE     L    +H+K
Sbjct: 1064 ELQEVIALTSQELEESREKVL-----ELEDELQESRGFRKKIKRLEESNKKLALELEHEK 1118

Query: 495  QSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDK 554
               +L      +  L+E  + LE+ L + +A   +  +Q++++ QR+ E        +D+
Sbjct: 1119 --GKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEE--------EDR 1168

Query: 555  QSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQAL 614
            Q                 +    +LQ  +EK+++K++ L+ QV + + E        +A 
Sbjct: 1169 Q----------------MKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAA 1212

Query: 615  REEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELH 674
              E       LQ     V++L  +  DL          +R+ +     S + AQ   EL 
Sbjct: 1213 SLELSEVKKELQAKEHLVQKLQAEADDL---------QIREGK----HSQEIAQFQAELA 1259

Query: 675  QELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGI----HSAQHPETQLDLQKPDVIKRKL 730
            +  A      + +   ++++  G+    +L   +       Q  + QLDL +    +++L
Sbjct: 1260 EARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQG-RKEL 1318

Query: 731  EEVQQLRRDI--------EDLRTTMSDRY 751
            E +QQL +++        EDL  T  D++
Sbjct: 1319 EGLQQLLQNVKSELEMAQEDLSMTQKDKF 1347



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 81/408 (19%), Positives = 169/408 (41%), Gaps = 65/408 (15%)

Query: 384 LQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKK 443
           + +L+++ T L++Q  Q    +  E+  L  KL AS+ E+  + +S++   Q+     ++
Sbjct: 533 VHDLRQQMTALQSQLQQ----VQLERTTLTSKLKASQAEISSL-QSVRQWYQQQLALAQE 587

Query: 444 QEERVKGRDKHIN-----------NLKKKCQKESEQNREKQQR-----------IETLER 481
              R++G   HI            +LK +    S+Q  E Q R           ++ +E 
Sbjct: 588 ARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEA 647

Query: 482 YLADLPTL------------EDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICRE 529
            + D                ED Q++ ++ +    +   + +    LE  LE+ +    +
Sbjct: 648 DMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQ 707

Query: 530 KEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQK 589
           ++ QLE+L+Q   +       L  + ++ + + +  E  +++ Q  YD LQ  + + Q +
Sbjct: 708 RDQQLEALQQEHLD-------LMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGE 760

Query: 590 MDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTL 649
                  +  L+ E    E   QA +   +  D   ++L    +E S +  + + + L +
Sbjct: 761 AASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETS-ETLEKLREELAI 819

Query: 650 Q----EHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLL 705
           +    EHL+Q         +TA L  ++ +     LQ  + +     + A   D  +S L
Sbjct: 820 KSGQVEHLQQ---------ETAALKKQMQKIKEQFLQQ-KVMVEAYRRDATSKDQLISEL 869

Query: 706 LGIH---SAQHPETQLDLQKPDVIKRKLE-EVQQLRRDIEDLRTTMSD 749
                   ++  E + +L +    KR  E E+ +L R++  +R  M+D
Sbjct: 870 KATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMAD 917



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 87/431 (20%), Positives = 184/431 (42%), Gaps = 50/431 (11%)

Query: 294  RLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQ--RKHI 351
            R+Q  + +LQ  A+ H        L  +       +  S E +L+ ++ L + +  RK I
Sbjct: 1043 RIQALEAELQ--AVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKI 1100

Query: 352  SQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKID 411
             +LE+  ++  L++     G+    G         L+  N+ L    A++   L +  + 
Sbjct: 1101 KRLEESNKKLALELEHEK-GKLTGLGQ----SNAALREHNSILETALAKREADLVQLNLQ 1155

Query: 412  LEKKLSASEVEVQLIR---ESLKVALQKHSEEVKKQEERVKGRDKHINN----LKKKCQK 464
            ++  L   E E + ++   ++L+ +L+K  E+V   +E+V        +     K    +
Sbjct: 1156 VQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLE 1215

Query: 465  ESEQNREKQQRIETLERYLADLPTLEDHQ-KQSQQLKDSELKSTELQEKVTELESLLEET 523
             SE  +E Q +   +++  A+   L+  + K SQ++   + +  E + ++  L+  L+E 
Sbjct: 1216 LSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQ 1275

Query: 524  QAICREKEIQLESLR----QREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSL 579
             +       ++E+L+    Q+E E  S       KQ ++ T  +G + E+E  Q+   ++
Sbjct: 1276 LSKQPVGNQEMENLKWEVDQKEREIQSL------KQQLDLTEQQGRK-ELEGLQQLLQNV 1328

Query: 580  QKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQR-----RDSALQQLRTAVKE 634
            +  +E  Q+ +   +     L+ +V++ +   + L ++ Q+     R  A +  +    E
Sbjct: 1329 KSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGE 1388

Query: 635  LSVQN-------QDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAV 687
             S  N        D       L+E LR      PP+     ++ E  + L SCLQ L+  
Sbjct: 1389 ASSSNPATPIKIPDCPVPASLLEELLR-----PPPA-----VSKEPLKNLNSCLQQLKQE 1438

Query: 688  CSIVTQRAQGH 698
               + ++ + H
Sbjct: 1439 MDSLQRQMEEH 1449



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 43/184 (23%), Positives = 77/184 (41%), Gaps = 20/184 (10%)

Query: 491 DHQKQSQQL-------KDSELKSTELQEKVTELESLLEETQAICREK---EIQLESLRQR 540
           +HQ Q Q++       +DS   S  L+    E +   EE   + +EK   E QLE+L   
Sbjct: 371 EHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQ---EEMLQVLKEKMRLEGQLEALSLE 427

Query: 541 EAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQK-------MDQL 593
            ++       LQ + +   T  +       S Q+R DSL   V+  +Q        M  L
Sbjct: 428 ASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDL 487

Query: 594 RSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHL 653
           ++ +++    +A      Q   E+ QR  + ++ ++ ++        DL ++   LQ  L
Sbjct: 488 QNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQL 547

Query: 654 RQAQ 657
           +Q Q
Sbjct: 548 QQVQ 551



 Score = 37.4 bits (85), Expect = 0.052
 Identities = 61/252 (24%), Positives = 106/252 (42%), Gaps = 28/252 (11%)

Query: 426 IRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLAD 485
           I++ L+ A  +H ++ ++    V+ R   I +        +E   E  Q ++   R    
Sbjct: 361 IKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQ 420

Query: 486 LPTLEDHQKQSQQLKD-SELK------STELQEKVT----------ELESLLEETQAICR 528
           L  L    + SQ LK+ +EL+      ST+LQ +V            L S ++  +  C 
Sbjct: 421 LEALS--LEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCW 478

Query: 529 EKEIQLESLRQR-EAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQ 587
           + E  +  L+   EA+ +S   S  D Q  EE   +    ++E  Q+   S    V   +
Sbjct: 479 DLERAMTDLQNMLEAKNASLASSNNDLQVAEEQY-QRLMAKVEDMQRSMLSKDNTVHDLR 537

Query: 588 QKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNL 647
           Q+M  L+SQ+    Q+V  E  T  +  + +Q   S+LQ +R   ++     Q   E  +
Sbjct: 538 QQMTALQSQL----QQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQ---EARV 590

Query: 648 TLQEHLRQAQPG 659
            LQ  +   Q G
Sbjct: 591 RLQGEMAHIQVG 602


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 76.6 bits (187), Expect = 8e-14
 Identities = 74/377 (19%), Positives = 167/377 (44%), Gaps = 45/377 (11%)

Query: 274 WHPREQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSN 333
           W  + Q  E    R+Q E IR Q E+M+ Q   +            ++   +    +   
Sbjct: 312 WEEKIQEQE-EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE--EKMRRQ 368

Query: 334 EHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTF 393
           E ++ EKE  + +Q + + + E+K+RE E ++H                  QE  RE   
Sbjct: 369 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE-----------------QEKIREQE- 410

Query: 394 LRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDK 453
                              EK+    ++  Q  R+  +  + +  E++++QEE+++ ++K
Sbjct: 411 -------------------EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK 451

Query: 454 HINNLKKKC-QKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEK 512
            +   ++K  ++E  +  EK+Q  E + R    +   E+  +Q +++ + E K  + +EK
Sbjct: 452 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEK 511

Query: 513 VTELESLLEETQAICREKEIQL----ESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVE 568
           V   E  + E +   RE+E ++    E +R++E  +       + ++  EE   +  E +
Sbjct: 512 VWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDK 571

Query: 569 MESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQL 628
           M   +++    ++ V +Q++K+ +   + Q  E+++ ++E   +   E+ Q ++  +++ 
Sbjct: 572 MWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQ 631

Query: 629 RTAVKELSVQNQDLIEK 645
              ++E     Q+  EK
Sbjct: 632 EEKIREQEEMTQEQEEK 648



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 68/335 (20%), Positives = 164/335 (48%), Gaps = 30/335 (8%)

Query: 337 LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRA 396
           L+EK  L++ ++   S+++  V+E + ++  A L          LL  Q+LQ E   L  
Sbjct: 226 LQEKLQLVESEK---SEIQLNVKELKRKLERAKL----------LLPQQQLQAEADHLGK 272

Query: 397 QFAQKTEALSR--EKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKH 454
           +    +  L    E+ +L  +L+  + E ++ R+  K+  Q+  E++++QEE+++ +++ 
Sbjct: 273 ELQSVSAKLQAQVEENELWNRLNQQQEE-KMWRQEEKI--QEWEEKIQEQEEKIREQEEK 329

Query: 455 INNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKST-----EL 509
           I   ++K +++ E   EK++++   E  + +       Q++    K+ +++       E 
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 389

Query: 510 QEKVTELESLLEETQAI--CREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEV 567
           +EK+ ELE  + E + I    EK  + E +R++E          + ++ + E   +  E 
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 449

Query: 568 EMESW--QKRYDSLQKI--VEKQQQKMDQLRSQVQSLEQ-EVAQEEGTSQALREEAQRRD 622
           E + W  +++    +KI   EK+Q++ +  R + +  EQ E+ +++       E+ ++++
Sbjct: 450 EKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQE 509

Query: 623 SALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 657
             + +    ++E   + ++  EK    +E +R+ +
Sbjct: 510 EKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQE 544



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 61/320 (19%), Positives = 153/320 (47%), Gaps = 21/320 (6%)

Query: 330 LNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQR 389
           +   E  ++E+E  + +Q + I + ++K+RE E +     + R     +  +   +E+ R
Sbjct: 439 IREQEEKIREQEKKMWRQEEKIHE-QEKIREEEKRQEQEEMWRQ----EEKIHEQEEIWR 493

Query: 390 ENTFLRAQFA----QKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQE 445
           +   +  Q      Q+ +   +E+   E++    E E ++ R+  K+   +  EE+ ++E
Sbjct: 494 QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKI---REQEEMWREE 550

Query: 446 ERVKGRDKHINNLKKKCQ-----KESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLK 500
           E++  ++K     K++ Q     ++ E+ RE+++++   E  + +    E  Q+Q +++ 
Sbjct: 551 EKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQE--EKRQEQEEKMW 608

Query: 501 DSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEET 560
             E K  E +EK+ E E  + E +   RE+E   +   ++  E        ++K   +E 
Sbjct: 609 KQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE 668

Query: 561 SGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQR 620
           +    E ++   +K+    ++ + +Q++ M +   ++   E+++ ++E   Q   E+ +R
Sbjct: 669 TMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 728

Query: 621 RDSAL--QQLRTAVKELSVQ 638
           ++  +  Q++R   +E  +Q
Sbjct: 729 QEEKMWEQEVRLRQQEEKMQ 748


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 87/382 (22%), Positives = 171/382 (44%), Gaps = 60/382 (15%)

Query: 350  HISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREK 409
            H   L+QK+  S+LQ+               L  L+ELQ +   L+   ++K E +S   
Sbjct: 1366 HAESLQQKLESSQLQIAG-------------LEHLRELQPKLDELQKLISKKEEDVSYLS 1412

Query: 410  IDL-EKKLSASEVEVQLI-RESLKVALQKHSE-EVKKQEERVKGRDKHINNLKKKCQKES 466
              L EK+ + ++++ ++I +E L  AL    E + K+ +ER+K     +  +K+K ++  
Sbjct: 1413 GQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIG 1472

Query: 467  EQNREKQQ-----------RIE-----------------TLERYLADLPTLEDHQKQSQQ 498
            E++R KQQ           R E                 T+ER    L  +E       +
Sbjct: 1473 EESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNK 1532

Query: 499  LKDSEL-KSTELQEK----VTELESLLEETQAI---CREKEIQLESLRQREAEFSSAGHS 550
             KD+ L +   LQE+    +TE++  L E Q++   C   ++ LE L + + +      S
Sbjct: 1533 EKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIES 1592

Query: 551  LQDKQSVEETSGEGPEVEM----ESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQ 606
            L+  +  E T  +    E+    E   + Y+++    E+ Q  ++ +R + Q L  ++  
Sbjct: 1593 LKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRS 1652

Query: 607  EEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDT 666
             E   +   ++ Q  +  +++++  +++ +   Q   +K L L+E   + +    P+ DT
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQ---QKILELEEENDRLRAEVHPAGDT 1709

Query: 667  AQLALE-LHQELASCLQDLQAV 687
            A+  +E L    AS  ++L+ V
Sbjct: 1710 AKECMETLLSSNASMKEELERV 1731



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 82/409 (20%), Positives = 176/409 (43%), Gaps = 55/409 (13%)

Query: 383  RLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEV-------EVQLIRESLKVALQ 435
            RL++ + ++   +    +K +AL REK+ LE+ +   +V       EVQ ++E+L   + 
Sbjct: 2126 RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVT 2185

Query: 436  KHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLER-------------- 481
            + +   K        RD+ I+  KK  +K S+  + K++ I   E               
Sbjct: 2186 QLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSI 2245

Query: 482  YLADLPTLEDHQKQSQQLKDSELKS-TELQEKV--------TELESLLEETQAICREK-- 530
            ++ +L       +  +Q+ +S+ ++  +LQ+KV         EL S LEET+ +      
Sbjct: 2246 HMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQN 2305

Query: 531  -----EIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEK 585
                 E +L+SL+ +  + S++    ++++   E      E ++++ +  Y+ L+  ++ 
Sbjct: 2306 ELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQA 2365

Query: 586  QQQKMDQLRSQVQSLEQEV-----AQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQ 640
             ++   +L  ++   EQ++      +EE    A+ E  Q+ D  +++L   + +      
Sbjct: 2366 SRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEE---- 2421

Query: 641  DLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDP 700
               E+N+ L+E  ++A         T QL   L       +Q    + S V   +   + 
Sbjct: 2422 ---EENIVLEEENKKA------VDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQND 2472

Query: 701  NLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSD 749
               ++      +     + L+K  +I+    E  +L+ +I  LR+ M D
Sbjct: 2473 RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDD 2521



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 64/284 (22%), Positives = 139/284 (48%), Gaps = 30/284 (10%)

Query: 376 FGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQ 435
           + +  ++ L+++ R+      Q  QK EAL  E+   + K+     +++L  ++   +L 
Sbjct: 56  YAEQLVVELKDIIRQKD---VQLQQKDEALQEERKAADNKIK----KLKLHAKAKLTSLN 108

Query: 436 KHSEEVKKQ-----------EERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLA 484
           K+ EE+K Q           EE++   DK     + + +K   + +EK++ I TL+  L 
Sbjct: 109 KYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLT 168

Query: 485 DLPTLEDHQKQSQQLKDSELKSTELQEK---VTELESLLEETQAICREKEIQLESLRQRE 541
                E   + S ++++  +   +LQEK   ++ L++ L +TQA    ++   + +R+++
Sbjct: 169 QAQA-EQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQA----EQAAQQVVREKD 223

Query: 542 AEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLE 601
           A F +    L + + ++  +    E EM   Q++   LQ+ +E+ ++ +      V  L+
Sbjct: 224 ARFETQVR-LHEDELLQLVTQADVETEM---QQKLRVLQRKLEEHEESLVGRAQVVDLLQ 279

Query: 602 QEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEK 645
           QE+   E  +Q L ++ Q+ ++    LR  V+    +++ L+EK
Sbjct: 280 QELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEK 323



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 87/429 (20%), Positives = 165/429 (38%), Gaps = 87/429 (20%)

Query: 395  RAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKH 454
            + +  +K  AL +EK  L+KKL       Q    S K  L+K  E+ +   E +K +   
Sbjct: 1159 KPELEEKILALEKEKEQLQKKL-------QEALTSRKAILKKAQEKERHLREELKQQKDD 1211

Query: 455  INNLKKKCQKESEQNRE-----KQQRIETLERYLADLPT--------------------L 489
             N L+++  ++S++N       +Q +I+  E     LP+                     
Sbjct: 1212 YNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKAT 1271

Query: 490  EDHQKQ------------------------------SQQLKDSELKSTELQEKVTELESL 519
            E H  Q                                QLK+ E +  EL+ KV+   S 
Sbjct: 1272 EQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSE 1331

Query: 520  LE-------ETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESW 572
            L        + Q    ++ +++ESL+    E      SLQ K    +    G E  +   
Sbjct: 1332 LTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLE-HLREL 1390

Query: 573  QKRYDSLQKIVEKQQQKMDQLRSQVQ-------SLEQEVAQEEGTSQALRE----EAQRR 621
            Q + D LQK++ K+++ +  L  Q+         ++ E+ ++E   +AL      +A+  
Sbjct: 1391 QPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEH 1450

Query: 622  DSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELA--- 678
            D  ++QL+  + E+  + +++ E++   Q+  R+ Q       +  +    L +EL+   
Sbjct: 1451 DERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLAR 1510

Query: 679  SCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRR 738
              ++ L    + V  +    +     +LG  +    E    + + D   R L E Q L  
Sbjct: 1511 GTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMD---RSLLENQSLSS 1567

Query: 739  DIEDLRTTM 747
              E L+  +
Sbjct: 1568 SCESLKLAL 1576



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 82/375 (21%), Positives = 159/375 (42%), Gaps = 57/375 (15%)

Query: 414  KKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQ 473
            K++ A +VE++L   S    L K SEEV + +E++  +   I +LK    +        Q
Sbjct: 1312 KEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQ 1371

Query: 474  QRIETLERYLADL-------PTLEDHQK-----------QSQQLKDSELKSTELQEKVTE 515
            Q++E+ +  +A L       P L++ QK            S QL + E   T++Q ++ E
Sbjct: 1372 QKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIE 1431

Query: 516  LESLLE--ETQAICREKE---------IQLESLRQREAEF---SSAGHSLQDKQSVEETS 561
             E L++   TQ   + KE         ++L  ++Q+  E    S A   +Q K      S
Sbjct: 1432 QEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALIS 1491

Query: 562  GEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEA--- 618
             +    E +S Q+     +  +E+  + +  + SQV +  +E     G    L+EE    
Sbjct: 1492 RKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKL 1551

Query: 619  -----------QRRDSALQQLRTAVKELSVQNQDLIEKNLTLQE----HLRQAQPGSPPS 663
                       Q   S+ + L+ A++ L+   + L+++  +L+        + Q      
Sbjct: 1552 ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKEL 1611

Query: 664  PDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKP 723
                ++ L+ ++ +++  + +Q V   V Q  Q     L   L    A   ET+  LQ+ 
Sbjct: 1612 QKEYEILLQSYENVSNEAERIQHVVEAVRQEKQ----ELYGKLRSTEANKKETEKQLQEA 1667

Query: 724  DVIKRKLEEVQQLRR 738
            +   +++EE+++  R
Sbjct: 1668 E---QEMEEMKEKMR 1679



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 91/453 (20%), Positives = 193/453 (42%), Gaps = 50/453 (11%)

Query: 317  SLPILEPAQWISILNSNEHLLKEKELL------IDKQRKHISQLEQKVRESELQVHSALL 370
            S  I E  +W      ++ L KE E+L      +  + + I  + + VR+ + +++  L 
Sbjct: 1595 SSKIAESTEW---QEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLR 1651

Query: 371  GRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESL 430
               A   +    +LQE ++E   ++ +  +  ++  ++ ++LE++      EV    ++ 
Sbjct: 1652 STEANKKET-EKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTA 1710

Query: 431  KVALQ---KHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLP 487
            K  ++     +  +K++ ERVK        L KK Q    +     + ++ L+       
Sbjct: 1711 KECMETLLSSNASMKEELERVK---MEYETLSKKFQSLMSEKDSLSEEVQDLK------- 1760

Query: 488  TLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLE-SLRQREAEFSS 546
                HQ +    K + L++TE  +  T +    E TQ+I  E E Q   S+  R     S
Sbjct: 1761 ----HQIEGNVSKQANLEATEKHDNQTNVTE--EGTQSIPGETEEQDSLSMSTRPTCSES 1814

Query: 547  AGHSLQDKQSVEETSGEGPEV-----EMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLE 601
               +     +V +      E+     +++  ++R   L++  +K ++    L ++  +L 
Sbjct: 1815 VPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLL 1874

Query: 602  QEVAQEEGTSQALREEAQRRDSALQQLR------TAVKELSVQNQDLIEKNLTLQEHLRQ 655
             +++ ++G  + L+EE  + +   QQ++      T +KE + + +D +E+ L  Q     
Sbjct: 1875 SQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELN 1934

Query: 656  AQPGSPPSPDT-AQLALEL----HQELASCLQDLQAVCSIVTQRAQGHDPNL--SLLLGI 708
               G+     T AQ+  EL     + L  C+ +L+     + +     +  +    L  I
Sbjct: 1935 GSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKI 1994

Query: 709  HSAQHPETQLDLQK--PDVIKRKLEEVQQLRRD 739
              AQ         K   +++K K +EV+QL++D
Sbjct: 1995 QGAQKEPGNKSHAKELQELLKEKQQEVKQLQKD 2027



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 88/427 (20%), Positives = 174/427 (40%), Gaps = 54/427 (12%)

Query: 330  LNSNEHLLKE-KELLIDKQRKHISQLEQKVRESELQV--HSALLGRPAPFGDVCLLRLQE 386
            L  N H  +E  E  +D++ K IS L Q + E +     +S+     +   D  L +++E
Sbjct: 696  LELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKE 755

Query: 387  LQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEE 446
            L    T LRAQ  Q           LE  L+ +E + +L  ES        +E++     
Sbjct: 756  LSMV-TELRAQVKQ-----------LEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSI 803

Query: 447  RVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKS 506
              K +D  I  L+ +      Q  E+   I +L+                 QL++ E + 
Sbjct: 804  EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQ----------------SQLQNKESEV 847

Query: 507  TELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPE 566
             E  E+V  + S +EE      +KE+++  + Q   E      +LQ  Q++EE   +  E
Sbjct: 848  LEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQ--QTIEEKDQQVTE 905

Query: 567  VEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQ 626
            +        +   +K+V+  ++K   L  ++++L++++       +A +E+ +  +    
Sbjct: 906  IS-------FSMTEKMVQLNEEKFS-LGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSS 957

Query: 627  QLRTAVKELSVQNQ----------DLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQE 676
             L+    E+S   Q          DL++K    ++  R+ Q       +  Q    L +E
Sbjct: 958  GLKQNYDEMSPAGQISKEELQHEFDLLKKEN--EQRKRKLQAALINRKELLQRVSRLEEE 1015

Query: 677  LASCLQDLQAVCSIV-TQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQ 735
            LA+   + +    +  T+R +  +   +             ++++     I  K  E+Q 
Sbjct: 1016 LANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQH 1075

Query: 736  LRRDIED 742
            +R+D+E+
Sbjct: 1076 IRKDLEE 1082



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 113/514 (21%), Positives = 207/514 (40%), Gaps = 89/514 (17%)

Query: 282  ELSTCRQQL-ELIR--LQMEQMQL----QNGAICHHPAAFGPSLPILEPAQWISILNSNE 334
            E  T  +++ EL R  ++MEQ  L    +N  +     +FG S+  L+        NS +
Sbjct: 2697 ETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQ--------NSRD 2748

Query: 335  HLLKEKELLIDKQRKHISQLEQKVRESEL-QVHSALLGRPA-PFGDVCLLRLQELQRENT 392
            H  +E + L  K    + +L Q   +  L +   ALL   A          L  L++   
Sbjct: 2749 HANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEK--- 2805

Query: 393  FLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRD 452
             L  Q   K E L    + L  +L  S  +VQ   +++  +LQ   + +  + E+ +  +
Sbjct: 2806 -LNQQLLSKDEQL----LHLSSQLEDSYNQVQSFSKAM-ASLQNERDHLWNELEKFRKSE 2859

Query: 453  KHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEK 512
            +         Q+ + Q       +++L++ ++ L    D  +  ++LK+ + +  ++ ++
Sbjct: 2860 EGK-------QRSAAQPSTSPAEVQSLKKAMSSLQN--DRDRLLKELKNLQQQYLQINQE 2910

Query: 513  VTELESL---LEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEM 569
            +TEL  L   L+E Q   +  +I  E LRQ    +    H L+    +E++S E  E  M
Sbjct: 2911 ITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLR----MEKSSWEIHERRM 2966

Query: 570  ESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDS------ 623
            +        L  I +K QQ      S +Q+L +E+      +Q L+ + QR+ S      
Sbjct: 2967 KE-----QYLMAISDKDQQ-----LSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSAS 3016

Query: 624  -------------ALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLA 670
                            QL  ++KE+  +   + + N    + L +    S    DT+Q  
Sbjct: 3017 PDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSL 3076

Query: 671  LELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLL-------LGIHSAQHPETQLDLQKP 723
             E  Q     L    AV     Q  Q    N+ +         G+H    PE   +L++P
Sbjct: 3077 RENQQHYGDLLNHC-AVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPE---ELREP 3132

Query: 724  DVIKRKLEEVQQ----LRRDIEDLRTTMSDRYAQ 753
               ++   E QQ     R+++ +LR  + +   Q
Sbjct: 3133 ---QQSFSEAQQQLCNTRQEVNELRKLLEEERDQ 3163



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 106/502 (21%), Positives = 211/502 (42%), Gaps = 82/502 (16%)

Query: 329 ILNSNEHLLKEKELLIDKQRK----HISQLEQKVRESELQVHSALLGRPAPFGDVCLLRL 384
           I+   +  L++K+  + ++RK     I +L+   +     ++  +    A  G V     
Sbjct: 67  IIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPT-- 124

Query: 385 QELQRENTFLRAQFAQKTEALSREKID---LEKKLSASEVEVQLIRESLKVALQKHSE-- 439
            E Q E    +   +   E +  EKI     EK+   S ++ QL +   +   Q  +E  
Sbjct: 125 -EPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEME 183

Query: 440 EVKKQEERVKGRDKHINNLKKKC-QKESEQN-----REKQQRIETLERY----LADLPTL 489
           E    +++++ +++ I+ L+ +  Q ++EQ      REK  R ET  R     L  L T 
Sbjct: 184 EFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQ 243

Query: 490 EDHQKQSQQ-LKDSELKSTELQEKVTE----LESLLEETQAICREKEIQLESLRQREAEF 544
            D + + QQ L+  + K  E +E +      ++ L +E  A  +  +I  + L+Q EAE 
Sbjct: 244 ADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEH 303

Query: 545 SSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIV-------EKQQQKMDQLRSQV 597
           ++  ++++ ++   +   E  E+E+   +  + +LQ+ +       E+  Q   +L S+ 
Sbjct: 304 NTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRY 363

Query: 598 QSLEQ--EVAQEEGTSQAL---------------------------REEAQRRDSALQQL 628
            +LEQ  +   EE TS  L                            E+A +    +QQL
Sbjct: 364 SALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQL 423

Query: 629 RTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPP--SPDTAQLALELHQELASCLQDLQ- 685
              +++ S +    + + L LQ+H   +Q   P   +  T  +  E    L   + +L+ 
Sbjct: 424 EDQLQQKSKEISQFLNR-LPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELEN 482

Query: 686 -----AVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDI 740
                 + SI  +  +  +  LS  + +  AQ+   + D        R++ E+  +  DI
Sbjct: 483 EKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD--------REVSEISIV--DI 532

Query: 741 EDLRTTMSDRYAQDMGENCVTQ 762
            + R++ ++   QD+ EN  +Q
Sbjct: 533 ANKRSSSAEESGQDVLENTFSQ 554



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 97/473 (20%), Positives = 196/473 (41%), Gaps = 114/473 (24%)

Query: 277  REQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHL 336
            +E + E +  ++++  +R  M+ +  +N  +      +   L      Q I+I +S +  
Sbjct: 2499 QEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLN-----QVITIKDSQQKQ 2553

Query: 337  LKEKELLIDKQRKH-ISQLEQKVRESE------------LQVHSALLGRPAPFGDVCLLR 383
            L E +L  +K+ ++  ++LE+K++ESE            LQ     L +      V + +
Sbjct: 2554 LLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQ 2613

Query: 384  LQE----LQRENTF--LRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKH 437
            L      LQ E T     AQ   K E + R    L    S+S+  +  + E L    ++ 
Sbjct: 2614 LTRQVTALQEEGTLGLYHAQLKVKEEEVHR----LSALFSSSQKRIAELEEELVCVQKEA 2669

Query: 438  SEEVKKQEERVKGRDKHINN-------------------------LKKKCQKESEQNREK 472
            +++V + E+++K   KH+++                         +++K    +++N+  
Sbjct: 2670 AKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGL 2729

Query: 473  QQRIETLERYLADLPTLEDHQKQS-QQLK---DSELKS-TELQEKVT---ELESLLEET- 523
              +I++  R ++ L    DH  +   +LK   D+ LK   +L+E+     E ++LL ET 
Sbjct: 2730 TAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA 2789

Query: 524  -------------------QAICREKEI-----QLESLRQREAEFSSAGHSLQDKQS--- 556
                               Q + +++++     QLE    +   FS A  SLQ+++    
Sbjct: 2790 FSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLW 2849

Query: 557  --VEE--TSGEGPE----------VEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQ 602
              +E+   S EG +           E++S +K   SLQ   ++  +++  L+ Q   + Q
Sbjct: 2850 NELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909

Query: 603  EVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQ 655
            E+            E     + LQ+ +   K   +  ++L ++NL+ Q  L Q
Sbjct: 2910 EIT-----------ELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQ 2951



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 79/382 (20%), Positives = 162/382 (42%), Gaps = 72/382 (18%)

Query: 336  LLKEKEL-LIDKQRKHISQLEQKVRESELQ------------------VHSALLGRPAPF 376
            L + KEL ++ + R  + QLE  + E+E Q                  +HS  L   A  
Sbjct: 750  LSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHS--LSIEAKS 807

Query: 377  GDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIR------ESL 430
             DV   +++ LQ E   ++ QF++++  +   +  L+ K S      + +R      E L
Sbjct: 808  KDV---KIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEEL 864

Query: 431  KVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQ---------------NREKQQ- 474
              AL +   E+ K ++ +  + + +  L++  +++ +Q               N EK   
Sbjct: 865  SQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSL 924

Query: 475  --RIETLERYLADLPTLEDHQKQSQQLKDSELKS-----------------TELQEKVTE 515
               I+TL+  L  L   E+ +K+  + +D+E+ S                  ELQ +   
Sbjct: 925  GVEIKTLKEQLNLLSRAEEAKKEQVE-EDNEVSSGLKQNYDEMSPAGQISKEELQHEFDL 983

Query: 516  LESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKR 575
            L+   E+ +   +   I  + L QR +       +L+D+   E    E    E+E  ++ 
Sbjct: 984  LKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKEN 1043

Query: 576  YDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKEL 635
             +  +K V  + Q+++        L+Q ++++E   Q +R++ + + +A +Q +  VK++
Sbjct: 1044 KEYSEKCVTSKCQEIEIY------LKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQM 1097

Query: 636  SVQNQDLIEKNLTLQEHLRQAQ 657
            +   QD   +   LQ  + + Q
Sbjct: 1098 NQTLQDKTNQIDLLQAEISENQ 1119



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 96/477 (20%), Positives = 191/477 (40%), Gaps = 78/477 (16%)

Query: 277  REQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPI---LEPAQWISILNSN 333
            +E +C  S  + QL  + + ME++++    + H    +         L+     ++   N
Sbjct: 2229 KEDNC--SVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286

Query: 334  EHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVC---------LLRL 384
            + LL + E    +   H SQ E    ESEL+     L   +   + C         ++R 
Sbjct: 2287 KELLSQLEET--RHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQ 2344

Query: 385  QELQRENTFLRAQFAQKTEALSREKID-LEKKLSASEVEVQLIRESLKVALQKHSEEVKK 443
            QE   +N+    +  +     SRE    L ++++  E ++  +    + A+Q    E+++
Sbjct: 2345 QEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQ 2404

Query: 444  QEERVKGRDKHINNLKKKCQKESEQN----REKQQRIETLERYLADLPTLEDHQKQSQQL 499
            Q       DK I  L+    +E E+N     E ++ ++   + +  L T++    Q +  
Sbjct: 2405 QH------DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQ 2458

Query: 500  KDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEE 559
             DS +KS         + SL  +   I  +     + L +R          L+  Q ++E
Sbjct: 2459 LDSFVKS---------MSSLQNDRDRIVGD----YQQLEERHLSII-----LEKDQLIQE 2500

Query: 560  TSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQ 619
             + E  +++ E            +   +  MD L S+   L+ E+ Q     + L +   
Sbjct: 2501 AAAENNKLKEE------------IRGLRSHMDDLNSENAKLDAELIQYR---EDLNQVIT 2545

Query: 620  RRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELAS 679
             +DS  +QL     +   QN++L  K   L+E L++++  +     +     E  Q+L+ 
Sbjct: 2546 IKDSQQKQLLEVQLQ---QNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSK 2602

Query: 680  CLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQL 736
             ++ L+   S +T++        +  LG++ AQ             +K K EEV +L
Sbjct: 2603 EIESLKVSISQLTRQVTALQEEGT--LGLYHAQ-------------LKVKEEEVHRL 2644



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 62/294 (21%), Positives = 130/294 (44%), Gaps = 45/294 (15%)

Query: 394 LRAQFAQKTEALSR--EKIDLEKKLSASEVE--------VQLIRESLKVALQKHSEEVKK 443
           L  Q  QK++ +S+   ++ L++  +AS+           Q + E    +LQK   E++ 
Sbjct: 423 LEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELEN 482

Query: 444 QEERVKGRDKHINNLKKKCQKESEQNR--EKQQRIETLERYLADLPTLEDHQKQSQQLKD 501
           ++  +      +  LK + +K S Q    E Q R    +R ++++  ++   K+S   ++
Sbjct: 483 EKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEE 542

Query: 502 S--ELKSTELQEKVTELESLLEETQAICRE---KEIQLESLRQREAEFSSAGHSLQDKQS 556
           S  ++      +K  EL  LL E +    E    ++QL+  R  EA+     H + D++ 
Sbjct: 543 SGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEAD-----HEVLDQKE 597

Query: 557 VEETSGEG-PEVEM-----------------ESWQKRYDSLQKIVEKQQQKMDQLRSQVQ 598
           +++  GEG   ++M                 ES     +  Q   E Q +  +++     
Sbjct: 598 MKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDA 657

Query: 599 SLEQEVAQEEG--TSQALREEAQRRDSALQQLRTAVKELSV---QNQDLIEKNL 647
            +E +  +++G  +  A+ +  Q     L++L++ + EL +   + Q++ EKNL
Sbjct: 658 GVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNL 711



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 52/255 (20%), Positives = 111/255 (43%), Gaps = 26/255 (10%)

Query: 489 LEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAG 548
           L+    Q   ++ +     ++QE++   E L+ E + I R+K++QL+   +   E   A 
Sbjct: 30  LDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAA 89

Query: 549 HSLQDKQSVEETSGEGPEVEMESWQKRYDSLQ----KIVEKQQQKMDQLRSQVQSLEQEV 604
            +   K  +        + ++ S  K  + ++     ++  + Q  +QL    +S  +E 
Sbjct: 90  DNKIKKLKLH------AKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEE 143

Query: 605 AQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSP 664
            + E     L+E+ +   +   QL  A  E   Q+   +E+ + +++ L++ +       
Sbjct: 144 MEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKE------E 197

Query: 665 DTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSL----LLGIHSAQHPETQLDL 720
             + L  +L Q  A      QA   +V ++    +  + L    LL + +    ET++  
Sbjct: 198 FISTLQAQLSQTQAE-----QAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQ- 251

Query: 721 QKPDVIKRKLEEVQQ 735
           QK  V++RKLEE ++
Sbjct: 252 QKLRVLQRKLEEHEE 266



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 72/370 (19%), Positives = 160/370 (43%), Gaps = 66/370 (17%)

Query: 402  TEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKK 461
            ++ L  EK  L  ++S  + E+++++E +   +   +++++++  RV         LK+ 
Sbjct: 1863 SQTLENEKNTLLSQISTKDGELKMLQEEV-TKMNLLNQQIQEELSRV-------TKLKET 1914

Query: 462  CQKESEQNREK-QQRIETLERYLADLPTLEDHQKQSQQLKDSELKS-----TELQEKVTE 515
             ++E +   E+   ++  L   + +        +   +L +SE+K+     +EL+E   E
Sbjct: 1915 AEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE---E 1971

Query: 516  LESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKR 575
             + L++E   +  E EI+ E L + +      G+    K+                    
Sbjct: 1972 KQQLVKEKTKV--ESEIRKEYLEKIQGAQKEPGNKSHAKE-------------------- 2009

Query: 576  YDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKEL 635
               LQ++++++QQ++ QL+      +++++  E T +AL E  Q             K+L
Sbjct: 2010 ---LQELLKEKQQEVKQLQKDCIRYQEKISALERTVKAL-EFVQTESQ---------KDL 2056

Query: 636  SVQNQDLIEKNLTLQEHLRQAQPGSPP----SPDTAQLALELHQELASCLQDLQAVCSIV 691
             +  ++L +      EH ++AQ           DT   A  +  +     ++LQ+    V
Sbjct: 2057 EITKENLAQ----AVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESV 2112

Query: 692  TQRAQGHDPNLSLLLGIHSAQHPETQLDLQ-KPDVIKRKLEEVQQLRRDIEDLRTTMS-- 748
              + +  D +L   L     +H + + ++Q K D ++R   E   L   I +++ T++  
Sbjct: 2113 KSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRR---EKVHLEETIGEIQVTLNKK 2169

Query: 749  DRYAQDMGEN 758
            D+  Q + EN
Sbjct: 2170 DKEVQQLQEN 2179



 Score = 37.7 bits (86), Expect = 0.040
 Identities = 66/307 (21%), Positives = 122/307 (39%), Gaps = 26/307 (8%)

Query: 384 LQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKK 443
           L+ L+ +   L   F +  E   +   +  K++S      QLI E  K A    S     
Sbjct: 686 LERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLN---QLIEEFKKNADNNSSAFTAL 742

Query: 444 QEERVKGRDKHINNLKKKCQ--------KESEQN---REKQQRIETLERYLADLPTLEDH 492
            EER    D+ ++ +K+           K+ E N    E+Q+R++   +   D    E  
Sbjct: 743 SEER----DQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQI 798

Query: 493 QKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQ 552
              S + K  ++K   LQ ++ +++    E   + R  + QL++      E +     + 
Sbjct: 799 HSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHIS 858

Query: 553 DKQSVEETSGEGPEVEMESWQKRYDSLQKI--VEKQQQKMDQLRSQVQ----SLEQEVAQ 606
            K  VEE S    + E+E  +     L+K   VE  QQ +++   QV     S+ +++ Q
Sbjct: 859 SK--VEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQ 916

Query: 607 EEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDT 666
                 +L  E +     L  L  A +    Q ++  E +  L+++  +  P    S + 
Sbjct: 917 LNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEE 976

Query: 667 AQLALEL 673
            Q   +L
Sbjct: 977 LQHEFDL 983


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 71/333 (21%), Positives = 151/333 (45%), Gaps = 23/333 (6%)

Query: 344  IDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTE 403
            ++K R++++ +E K RE + +    +  +     D+    + ++  +N+    +   +  
Sbjct: 849  LEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA--EIMKMSGDNSSQLTKMNDELR 906

Query: 404  ALSREKIDLEKKLSASEVEVQLIRESLK----VALQKHSEEVKKQEERVKGRDKHINNLK 459
               R+  +L+ KL+ +      +++S++     A Q   E  KK EE  K  ++ +++L+
Sbjct: 907  LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE 966

Query: 460  KKCQKESEQNREKQQRIE--TLERYLADLPTLEDHQKQ----SQQLKDSELKSTELQEKV 513
            KK +    Q +E + R E  T E        L++ QK       +LK +  +++ L +++
Sbjct: 967  KKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL 1026

Query: 514  TELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQ 573
             EL    ++ +A  +  E  ++ + Q   E +    SL+D +          +   E+  
Sbjct: 1027 EELRKQADKAKA-AQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL 1085

Query: 574  KRYDSLQK---IVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRT 630
            K  + L K   ++  + QKM++ R ++++L+Q  AQ+     AL+EE  +    L + R 
Sbjct: 1086 KNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1145

Query: 631  AV-------KELSVQNQDLIEKNLTLQEHLRQA 656
             V       +E SV N  L+E      + ++ A
Sbjct: 1146 EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDA 1178



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 109/506 (21%), Positives = 206/506 (40%), Gaps = 89/506 (17%)

Query: 279  QSCELSTCRQQLELIRL----QMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNE 334
            ++ E +  + Q+E +RL    ++E +Q Q  +     AA    +  L  A+ + ++   E
Sbjct: 606  ETAEFAELKTQIEKMRLDYQHEIENLQNQQDS---ERAAHAKEMEALR-AKLMKVIKEKE 661

Query: 335  HLLKEKELLIDK-QRKHISQLEQ---KVRESELQVHSALLGRPAPFGDVCLLRLQELQRE 390
            + L+     +DK + +H+ ++E    K++E+E++V               L  LQ    E
Sbjct: 662  NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE-------------LEVLQAKCNE 708

Query: 391  NTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKG 450
             T +   F  + +A   + +DL+               +L+ A  +   E+KK  ++++ 
Sbjct: 709  QTKVIDNFTSQLKATEEKLLDLD---------------ALRKASSEGKSEMKKLRQQLEA 753

Query: 451  RDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQ 510
             +K I +L      E E+N E  +                     +++L+  ELK T LQ
Sbjct: 754  AEKQIKHL------EIEKNAESSKASSI-----------------TRELQGRELKLTNLQ 790

Query: 511  EKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEME 570
            E ++E+  + E       EKE+Q+  L+++ AE S    S+Q  +S++ET  +  + E E
Sbjct: 791  ENLSEVSQVKETL-----EKELQI--LKEKFAEASEEAVSVQ--RSMQETVNKLHQKE-E 840

Query: 571  SWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRT 630
             +      L+K+ E       + R + +  EQ +  +E     + E  +       QL  
Sbjct: 841  QFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTK 900

Query: 631  AVKELSVQNQDLIEKNLTLQEHLRQA-------QPGSPPSPDTAQLALELHQ----ELAS 679
               EL ++ +D+ E  L L +    A       +  +  +  + Q A + H+    EL  
Sbjct: 901  MNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELER 960

Query: 680  CLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQK-----PDVIKRKLEEVQ 734
             L DL+        + Q               +H E   +LQK      D +K   EE  
Sbjct: 961  KLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1020

Query: 735  QLRRDIEDLRTTMSDRYAQDMGENCV 760
             L +++E+LR       A    E+ +
Sbjct: 1021 GLLQELEELRKQADKAKAAQTAEDAM 1046



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 96/444 (21%), Positives = 189/444 (42%), Gaps = 68/444 (15%)

Query: 337 LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQEL--------- 387
           + EK  +++ + K ++   Q+V E   ++ S    +PA   D+ L  LQE+         
Sbjct: 460 VSEKSRIMELE-KDLALRVQEVAELRRRLES---NKPAGDVDMSLSLLQEISSLQEKLEV 515

Query: 388 -----QRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEV- 441
                QRE T L+  F  + E   +E   L         E + ++  L+ A +++S+ + 
Sbjct: 516 TRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 575

Query: 442 ---KKQEERVKGRDKHINNLKKKCQK----ESEQNREKQQRIETLERYLADLPTLEDHQK 494
               K E  +    + +  LK    K    E+ +  E + +IE +           D+Q 
Sbjct: 576 LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRL---------DYQH 626

Query: 495 QSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDK 554
           + + L++ +   +E      E+E+L  +   + +EKE  LE++R +  +        Q  
Sbjct: 627 EIENLQNQQ--DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED-----QHL 679

Query: 555 QSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQAL 614
             +E+T  +  E E++   K  + LQ    +Q + +D   SQ+++ E+++   +   +A 
Sbjct: 680 VEMEDTLNKLQEAEIK--VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS 737

Query: 615 REEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELH 674
            E         QQL  A K++         K+L ++++   ++  S        +  EL 
Sbjct: 738 SEGKSEMKKLRQQLEAAEKQI---------KHLEIEKNAESSKASS--------ITRELQ 780

Query: 675 -QELASCLQDLQAVCSIVTQRAQGHDPNLSLL---LGIHSAQHPETQLDLQKP-DVIKRK 729
            +EL   L +LQ   S V+Q  +  +  L +L       S +    Q  +Q+  + + +K
Sbjct: 781 GRELK--LTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK 838

Query: 730 LEEVQQLRRDIEDLRTTMSDRYAQ 753
            E+   L  D+E LR  ++D  A+
Sbjct: 839 EEQFNMLSSDLEKLRENLADMEAK 862



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 73/328 (22%), Positives = 152/328 (46%), Gaps = 44/328 (13%)

Query: 329  ILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQ 388
            IL + +  L + E  +   R+  S L Q++ E   Q   A   + A   +  +  ++++ 
Sbjct: 997  ILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKA---KAAQTAEDAMQIMEQMT 1053

Query: 389  RENTFLRAQF--AQKTEALSREKIDLEKKLSASEVE-VQLIRESLKVALQKHSEEVKKQE 445
            +E T   A     ++T A  + ++D  K+ +   VE +   +E L V  QK  EE +K+ 
Sbjct: 1054 KEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK-MEEFRKEI 1112

Query: 446  ERVKG----RDKHINNLKKKCQKESEQ---NREK---QQRIETLERYLADLPTLEDHQKQ 495
            E +K     + + ++ L+++  K +E+   +R++    Q++E  ER + +   LE  +++
Sbjct: 1113 ETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEE-ERSVLNNQLLEMKKRE 1171

Query: 496  SQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQ 555
            S+ +KD++ +   LQ+ ++        T A+  EK+ +LE LR           S +   
Sbjct: 1172 SKFIKDADEEKASLQKSISI-------TSALLTEKDAELEKLRNEVTVLRGENASAKSLH 1224

Query: 556  SVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALR 615
            SV +T                  L+    K + K+  L  Q++  +++++   G +    
Sbjct: 1225 SVVQT------------------LESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQA 1266

Query: 616  EEAQR-RDSALQQLRTAVKELSVQNQDL 642
            +E +R ++S +  L + + +L  +NQDL
Sbjct: 1267 DEDERAQESQIDFLNSVIVDLQRKNQDL 1294



 Score = 37.0 bits (84), Expect = 0.068
 Identities = 56/214 (26%), Positives = 94/214 (43%), Gaps = 41/214 (19%)

Query: 467 EQNREKQQRIETL--ERYL--ADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEE 522
           E  +EKQQ IE L  ER L  A++     H  + +Q  +  L      + V ELE+ +++
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ--ELALARDGHDQHVLELEAKMDQ 412

Query: 523 ----TQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDS 578
                +A  REK   +E L Q E E       LQ +   E  +    EV   S + R   
Sbjct: 413 LRTMVEAADREK---VELLNQLEEEKRKV-EDLQFRVEEESITKGDLEVATVSEKSRIME 468

Query: 579 LQKIVEKQQQKMDQLRSQVQ------------SLEQEVAQEEGTSQALREEAQRRDSALQ 626
           L+K +  + Q++ +LR +++            SL QE++  +   +  R + QR  ++L+
Sbjct: 469 LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK 528

Query: 627 Q---------------LRTAVKELSVQNQDLIEK 645
           +               L TA ++LS +N+ L  K
Sbjct: 529 EHFGAREETHQKEIKALYTATEKLSKENESLKSK 562


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 71/333 (21%), Positives = 151/333 (45%), Gaps = 23/333 (6%)

Query: 344  IDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTE 403
            ++K R++++ +E K RE + +    +  +     D+    + ++  +N+    +   +  
Sbjct: 884  LEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA--EIMKMSGDNSSQLTKMNDELR 941

Query: 404  ALSREKIDLEKKLSASEVEVQLIRESLK----VALQKHSEEVKKQEERVKGRDKHINNLK 459
               R+  +L+ KL+ +      +++S++     A Q   E  KK EE  K  ++ +++L+
Sbjct: 942  LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE 1001

Query: 460  KKCQKESEQNREKQQRIE--TLERYLADLPTLEDHQKQ----SQQLKDSELKSTELQEKV 513
            KK +    Q +E + R E  T E        L++ QK       +LK +  +++ L +++
Sbjct: 1002 KKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL 1061

Query: 514  TELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQ 573
             EL    ++ +A  +  E  ++ + Q   E +    SL+D +          +   E+  
Sbjct: 1062 EELRKQADKAKA-AQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL 1120

Query: 574  KRYDSLQK---IVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRT 630
            K  + L K   ++  + QKM++ R ++++L+Q  AQ+     AL+EE  +    L + R 
Sbjct: 1121 KNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1180

Query: 631  AV-------KELSVQNQDLIEKNLTLQEHLRQA 656
             V       +E SV N  L+E      + ++ A
Sbjct: 1181 EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDA 1213



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 109/506 (21%), Positives = 206/506 (40%), Gaps = 89/506 (17%)

Query: 279  QSCELSTCRQQLELIRL----QMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNE 334
            ++ E +  + Q+E +RL    ++E +Q Q  +     AA    +  L  A+ + ++   E
Sbjct: 641  ETAEFAELKTQIEKMRLDYQHEIENLQNQQDS---ERAAHAKEMEALR-AKLMKVIKEKE 696

Query: 335  HLLKEKELLIDK-QRKHISQLEQ---KVRESELQVHSALLGRPAPFGDVCLLRLQELQRE 390
            + L+     +DK + +H+ ++E    K++E+E++V               L  LQ    E
Sbjct: 697  NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE-------------LEVLQAKCNE 743

Query: 391  NTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKG 450
             T +   F  + +A   + +DL+               +L+ A  +   E+KK  ++++ 
Sbjct: 744  QTKVIDNFTSQLKATEEKLLDLD---------------ALRKASSEGKSEMKKLRQQLEA 788

Query: 451  RDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQ 510
             +K I +L      E E+N E  +                     +++L+  ELK T LQ
Sbjct: 789  AEKQIKHL------EIEKNAESSKASSI-----------------TRELQGRELKLTNLQ 825

Query: 511  EKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEME 570
            E ++E+  + E       EKE+Q+  L+++ AE S    S+Q  +S++ET  +  + E E
Sbjct: 826  ENLSEVSQVKETL-----EKELQI--LKEKFAEASEEAVSVQ--RSMQETVNKLHQKE-E 875

Query: 571  SWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRT 630
             +      L+K+ E       + R + +  EQ +  +E     + E  +       QL  
Sbjct: 876  QFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTK 935

Query: 631  AVKELSVQNQDLIEKNLTLQEHLRQA-------QPGSPPSPDTAQLALELHQ----ELAS 679
               EL ++ +D+ E  L L +    A       +  +  +  + Q A + H+    EL  
Sbjct: 936  MNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELER 995

Query: 680  CLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQK-----PDVIKRKLEEVQ 734
             L DL+        + Q               +H E   +LQK      D +K   EE  
Sbjct: 996  KLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1055

Query: 735  QLRRDIEDLRTTMSDRYAQDMGENCV 760
             L +++E+LR       A    E+ +
Sbjct: 1056 GLLQELEELRKQADKAKAAQTAEDAM 1081



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 96/444 (21%), Positives = 189/444 (42%), Gaps = 68/444 (15%)

Query: 337 LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQEL--------- 387
           + EK  +++ + K ++   Q+V E   ++ S    +PA   D+ L  LQE+         
Sbjct: 495 VSEKSRIMELE-KDLALRVQEVAELRRRLES---NKPAGDVDMSLSLLQEISSLQEKLEV 550

Query: 388 -----QRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEV- 441
                QRE T L+  F  + E   +E   L         E + ++  L+ A +++S+ + 
Sbjct: 551 TRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 610

Query: 442 ---KKQEERVKGRDKHINNLKKKCQK----ESEQNREKQQRIETLERYLADLPTLEDHQK 494
               K E  +    + +  LK    K    E+ +  E + +IE +           D+Q 
Sbjct: 611 LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRL---------DYQH 661

Query: 495 QSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDK 554
           + + L++ +   +E      E+E+L  +   + +EKE  LE++R +  +        Q  
Sbjct: 662 EIENLQNQQ--DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED-----QHL 714

Query: 555 QSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQAL 614
             +E+T  +  E E++   K  + LQ    +Q + +D   SQ+++ E+++   +   +A 
Sbjct: 715 VEMEDTLNKLQEAEIK--VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS 772

Query: 615 REEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELH 674
            E         QQL  A K++         K+L ++++   ++  S        +  EL 
Sbjct: 773 SEGKSEMKKLRQQLEAAEKQI---------KHLEIEKNAESSKASS--------ITRELQ 815

Query: 675 -QELASCLQDLQAVCSIVTQRAQGHDPNLSLL---LGIHSAQHPETQLDLQKP-DVIKRK 729
            +EL   L +LQ   S V+Q  +  +  L +L       S +    Q  +Q+  + + +K
Sbjct: 816 GRELK--LTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK 873

Query: 730 LEEVQQLRRDIEDLRTTMSDRYAQ 753
            E+   L  D+E LR  ++D  A+
Sbjct: 874 EEQFNMLSSDLEKLRENLADMEAK 897



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 73/328 (22%), Positives = 152/328 (46%), Gaps = 44/328 (13%)

Query: 329  ILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQ 388
            IL + +  L + E  +   R+  S L Q++ E   Q   A   + A   +  +  ++++ 
Sbjct: 1032 ILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKA---KAAQTAEDAMQIMEQMT 1088

Query: 389  RENTFLRAQF--AQKTEALSREKIDLEKKLSASEVE-VQLIRESLKVALQKHSEEVKKQE 445
            +E T   A     ++T A  + ++D  K+ +   VE +   +E L V  QK  EE +K+ 
Sbjct: 1089 KEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK-MEEFRKEI 1147

Query: 446  ERVKG----RDKHINNLKKKCQKESEQ---NREK---QQRIETLERYLADLPTLEDHQKQ 495
            E +K     + + ++ L+++  K +E+   +R++    Q++E  ER + +   LE  +++
Sbjct: 1148 ETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEE-ERSVLNNQLLEMKKRE 1206

Query: 496  SQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQ 555
            S+ +KD++ +   LQ+ ++        T A+  EK+ +LE LR           S +   
Sbjct: 1207 SKFIKDADEEKASLQKSISI-------TSALLTEKDAELEKLRNEVTVLRGENASAKSLH 1259

Query: 556  SVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALR 615
            SV +T                  L+    K + K+  L  Q++  +++++   G +    
Sbjct: 1260 SVVQT------------------LESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQA 1301

Query: 616  EEAQR-RDSALQQLRTAVKELSVQNQDL 642
            +E +R ++S +  L + + +L  +NQDL
Sbjct: 1302 DEDERAQESQIDFLNSVIVDLQRKNQDL 1329



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 47/213 (22%), Positives = 90/213 (42%), Gaps = 29/213 (13%)

Query: 467 EQNREKQQRIETL--ERYL--ADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEE 522
           E  +EKQQ IE L  ER L  A++     H  + +Q  +  L      + V ELE+ +++
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ--ELALARDGHDQHVLELEAKMDQ 412

Query: 523 TQAI--------------CREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVE 568
            + +                E++ ++E L+ R  E S     L+ +  +E    +  E  
Sbjct: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQS 472

Query: 569 MESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRD------ 622
           +   + + D LQ+ +E  +      +S++  LE+++A        LR   +         
Sbjct: 473 LLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVD 532

Query: 623 ---SALQQLRTAVKELSVQNQDLIEKNLTLQEH 652
              S LQ++ +  ++L V   D   +  +L+EH
Sbjct: 533 MSLSLLQEISSLQEKLEVTRTDHQREITSLKEH 565



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 39/180 (21%), Positives = 74/180 (41%), Gaps = 13/180 (7%)

Query: 538 RQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQV 597
           +Q+  E   A   L+  +  + TS  G E+E E    R    Q ++E +  KMDQLR+ V
Sbjct: 360 KQQHIEQLLAERDLERAEVAKATSHVG-EIEQELALARDGHDQHVLELEA-KMDQLRTMV 417

Query: 598 QS-----------LEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKN 646
           ++           LE+E  + E     + EE+  +     Q +     +    Q L+ + 
Sbjct: 418 EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEK 477

Query: 647 LTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLL 706
               +  R+ +     +       +EL ++LA  +Q++  +   +       D ++SL L
Sbjct: 478 TKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSL 537


>gi|4504063 golgin 97 [Homo sapiens]
          Length = 767

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 86/397 (21%), Positives = 169/397 (42%), Gaps = 40/397 (10%)

Query: 383 RLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVK 442
           ++ +L++E   L AQ  Q+ +  S        ++   E   Q     +K  L K  E + 
Sbjct: 138 KMDQLEKEKNILTAQL-QEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLG 196

Query: 443 KQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDS 502
           K E+ ++ R + ++  +++    ++ + +  Q++E L+R+ + L    DH   S+     
Sbjct: 197 KMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASK----- 251

Query: 503 ELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDK-QSVE--- 558
               T  + K+T LE   +E QA+ ++  I L+ +     E       LQ+K  S+E   
Sbjct: 252 ----TGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRL 307

Query: 559 ETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQ---VQSLEQEVAQEEGTSQALR 615
           E +  G E   E  +++  + Q + + +QQ +    SQ   + +LE  V + E T QA  
Sbjct: 308 EQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASE 367

Query: 616 EEAQRRDSALQQLRTAVKELSVQNQD--------------LIEKNLTLQEHLRQAQPGSP 661
           E+ Q+    +    T ++EL+  NQ+               +E+   L+  +   +    
Sbjct: 368 EQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRA 427

Query: 662 PSPDTAQLAL-ELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDL 720
               TA+  + +L QE A+    L+   +   +  Q H   L  L    S +   +    
Sbjct: 428 ADQTTAEQGMRQLEQENAA----LKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMA 483

Query: 721 QKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDMGE 757
           Q  + ++++ EE QQ   ++    T + D   Q++ E
Sbjct: 484 QALEEVRKQREEFQQQAANL----TAIIDEKEQNLRE 516



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 91/400 (22%), Positives = 168/400 (42%), Gaps = 56/400 (14%)

Query: 394 LRAQFAQKTEALSREKIDLEKKLS--ASEVE-VQLIRESLKVALQKHSE-EVKKQEERVK 449
           L +Q  ++ E + +    LE +LS  A +V  +Q I+E L++AL+KH +  ++K +E+ +
Sbjct: 56  LSSQLLRRNEQIRK----LEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNE 111

Query: 450 ----GRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELK 505
                R K    L     ++ ++  EK  ++E  +  L           Q Q++K+  + 
Sbjct: 112 TFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILT---------AQLQEMKNQSMN 162

Query: 506 STELQEKVTELESLLEETQAICREKEIQL---ESLRQREAEFSSAGHSLQDKQSVEETSG 562
             + ++++ ELE    + Q + + K + L   ESL + E E  +    L   Q     S 
Sbjct: 163 LFQRRDEMDELEGF--QQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSN 220

Query: 563 E---GPEVEMESWQKRYDSLQK-----IVEK--QQQKMDQLRSQVQSLEQEVAQEEGTSQ 612
           +       ++E  Q+ Y +L++     I  K   + K+  L  + Q L+  + Q     Q
Sbjct: 221 QMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQ 280

Query: 613 ALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEH----LRQAQPGSPPSPDTAQ 668
            +  E Q ++  +  L+  V  L    +  +E+NL+ +EH    L++         DT Q
Sbjct: 281 KVTAETQEKEDVITHLQEKVASL----EKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQ 336

Query: 669 LALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQ----------- 717
             L      A  +  L+     + Q  Q  +  L    GI +AQ  + Q           
Sbjct: 337 QLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSH 396

Query: 718 LDLQKPDVIKRKLEEVQQLRRDIEDL-RTTMSDRYAQDMG 756
           +  Q   + ++ LE  Q L   I  L RT  +D+   + G
Sbjct: 397 VQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQG 436



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 91/406 (22%), Positives = 171/406 (42%), Gaps = 94/406 (23%)

Query: 330 LNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQR 389
           L+  +H+L +KE  + K  +   +LE + RE   +    L+       D+   +L+ELQR
Sbjct: 181 LSKIKHMLLKKEESLGKMEQ---ELEARTRELS-RTQEELMNSNQMSSDLSQ-KLEELQR 235

Query: 390 ENTFLRAQFAQKTEALSREKIDLEKKLSA---SEVEVQLIRESLKVALQKHSEEVKKQEE 446
             + L  Q     + +   K   E K++A    E E+Q + + L + LQK + E +++E+
Sbjct: 236 HYSTLEEQ----RDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKED 291

Query: 447 RVKGRDKHINNLKKKCQKE----------------SEQNREKQQR------------IET 478
            +    + + +L+K+ ++                 +EQN E  ++            I T
Sbjct: 292 VITHLQEKVASLEKRLEQNLSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINT 351

Query: 479 LERYLADLP-TLEDHQKQSQQLKD--------------SELKSTELQEKVTELES-LLEE 522
           LE  + +L  TL+  ++Q QQ K               +  +S+ +Q++   LE   LE 
Sbjct: 352 LETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLER 411

Query: 523 TQAI---------------------CREKEIQLESLRQ--REAEFSSAGHSLQDKQSVEE 559
           TQA+                      R+ E +  +L++   E E S   H  + K+  EE
Sbjct: 412 TQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEE 471

Query: 560 TSG------------EGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQ- 606
            S             E    + E +Q++  +L  I+++++Q + +    +   EQE+ Q 
Sbjct: 472 WSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQL 531

Query: 607 EEGTSQALRE--EAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQ 650
           E G + AL +  + Q    AL+ L+     +  + +DL+     LQ
Sbjct: 532 ERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQ 577



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 83/363 (22%), Positives = 148/363 (40%), Gaps = 69/363 (19%)

Query: 330 LNSNEH---LLKEKELLIDK--------------QRKHISQLEQKVRESE--LQVHSALL 370
           L+  EH   LLKEK L                  Q K I+ LE +VRE E  LQ     L
Sbjct: 311 LSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQL 370

Query: 371 GRPAPFGDVCLLRLQEL----------QRENTFLRAQFAQKTEALSREKIDLEKKLSASE 420
            +          ++QEL          Q++   L  QF ++T+AL  + + LE+  +A +
Sbjct: 371 QQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQ 430

Query: 421 VEVQL--------------IRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKES 466
              +                R   + +LQ H  E+KK +E    R+     + +  ++  
Sbjct: 431 TTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVR 490

Query: 467 EQNREKQQRIETLERYLAD--------LPTLEDHQKQSQQLKDSE----LKSTELQEKVT 514
           +Q  E QQ+   L   + +           L   +++  QL+       L+  +LQ ++ 
Sbjct: 491 KQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELE 550

Query: 515 ELESLLEETQAICREKE--------IQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPE 566
            L +L  E  A+  E+E        +Q E+L   E+  +S   ++QD      T+G  P 
Sbjct: 551 ALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTS--RAMQDPVFQLPTAGRTPN 608

Query: 567 VEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQ 626
            E+ +       LQK  +  +Q++ +    ++ ++Q + +   T Q  +E   R D+ L 
Sbjct: 609 GEVGAMD--LTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQ--KELKIRPDNELF 664

Query: 627 QLR 629
           ++R
Sbjct: 665 EVR 667



 Score = 33.9 bits (76), Expect = 0.58
 Identities = 60/271 (22%), Positives = 109/271 (40%), Gaps = 51/271 (18%)

Query: 288 QQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQ 347
           Q LE +R Q E+ Q Q                    A   +I++  E  L+EK  ++ ++
Sbjct: 484 QALEEVRKQREEFQQQ-------------------AANLTAIIDEKEQNLREKTEVLLQK 524

Query: 348 RKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSR 407
            + I QLE+    + LQ+H                   +LQ E   LR   A++  A+  
Sbjct: 525 EQEILQLERGHNSALLQIH-------------------QLQAELEALRTLKAEEA-AVVA 564

Query: 408 EKIDLEKKLSASEVEVQLIRES--LKVALQKHSEEVKKQEERVKGR--DKHINNLKKKCQ 463
           E+ DL +     + E   + ES     A+Q    ++        G      +  L+K+ Q
Sbjct: 565 EQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQ 624

Query: 464 KESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEK----VTELESL 519
              +Q  EK + I+ +++ + +L   +  QK+ +   D+EL   E++EK    +  +   
Sbjct: 625 DLEQQLLEKNKTIKQMQQRMLEL--RKTLQKELKIRPDNEL--FEVREKPGPEMANMAPS 680

Query: 520 LEETQAICREKEIQLESLRQREAEFSSAGHS 550
           +     +   +EI  E L+    +F S   S
Sbjct: 681 VTNNTDLTDAREINFEYLKHVVLKFMSCRES 711


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 139/626 (22%), Positives = 253/626 (40%), Gaps = 138/626 (22%)

Query: 246  GVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQSCELSTCRQQLELIRLQMEQ----MQ 301
            G +   LQ A   S  L S+  +  PD      Q  E+    Q+   +R Q+E+    +Q
Sbjct: 670  GEVEQNLQAAKQCSSTLASRFQEHCPDL---ERQEAEVHKLGQRFNNLRQQVERRAQSLQ 726

Query: 302  LQNGAICH------HPAAFGPSLPILEPAQWISILNSNEHLLKEKELL---------IDK 346
                A  H      H   F  S+P  EP +  S+      L  +K LL         + K
Sbjct: 727  SAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQK 786

Query: 347  QRKHISQLEQKVRESELQVHS--ALL----GRPAPFGDVCLLR--LQELQRENTFLRAQF 398
               +  Q +Q V++ EL+     +LL    GR +       L+    +++ E   L A+F
Sbjct: 787  ICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKF 846

Query: 399  AQKTEALSREKI---DLEKKLSASEVEVQLIRESL---------------KVALQKHSEE 440
             +   A++R+++   +    L   + EV++  E+L               +  L + +E 
Sbjct: 847  TE-VYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETER 905

Query: 441  VKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIE--TLERYLADLPTLEDHQKQSQQ 498
             ++ E  VK   + I  L+ +  +ES   +E  +++    LE     L      ++   Q
Sbjct: 906  RRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQ 965

Query: 499  LKDSELKSTELQEKVTELES---------------------------LLEETQAICREK- 530
            L   EL++ +LQ +  E E+                           L EE +A+ R+K 
Sbjct: 966  LLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKG 1025

Query: 531  --EIQLESLRQREA----EFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVE 584
              E ++  L+QR A    E S A   + +K+ V+  +    E E +  Q+ +    ++ E
Sbjct: 1026 AREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLRE 1085

Query: 585  KQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQD--- 641
            KQ++++  L+ +++ LE+E A  EG           +D+A ++    V +L+ Q +D   
Sbjct: 1086 KQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATER---EVSDLTRQYEDEAA 1142

Query: 642  ------------------LIEKN--LTLQEHLRQ-AQPGSPPSPDTAQLALEL------- 673
                              L E+N  + +QE +R+  +P      + A L LEL       
Sbjct: 1143 KARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKY 1202

Query: 674  ---HQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLG--IHSAQHPETQLDLQ------- 721
                ++L S   +L+A+      R +G    +  +    I     PE + +LQ       
Sbjct: 1203 RGAEEQLRSYQSELEAL------RRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIV 1256

Query: 722  -KPDVIKRKLEEVQQLRRDIEDLRTT 746
             K  +I+R   E+ QL+++I+ L+ T
Sbjct: 1257 DKTRLIERCDLEIYQLKKEIQALKDT 1282



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 88/396 (22%), Positives = 174/396 (43%), Gaps = 39/396 (9%)

Query: 354  LEQKVRESELQVHSALLGRPAPFGD--VCLLRLQELQRENTFLRAQ-----FAQKTEALS 406
            +++KVRE         + RP P  +  V  LRL+ +++E  +  A+     +  + EAL 
Sbjct: 1170 VQEKVRE---------IVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALR 1220

Query: 407  REKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKES 466
            R    +E K    EV        ++  LQ+  EE+  +   ++  D  I  LK    KE 
Sbjct: 1221 RRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLK----KEI 1276

Query: 467  EQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAI 526
            +  ++ + +++T E     L   ED Q + +++     K +E Q+K  +LE         
Sbjct: 1277 QALKDTKPQVQTKEVVQEILQFQEDPQTK-EEVASLRAKLSEEQKKQVDLE--------- 1326

Query: 527  CREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQ 586
             RE+  Q E + ++E E S     +  ++ V      G   E  ++ +  D   + ++K 
Sbjct: 1327 -RERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKL 1385

Query: 587  QQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKN 646
            + ++ +L+ +   LE+++ + E   QA R EA+R    LQQ   A+++   +  +  EK 
Sbjct: 1386 RAELRRLQRRRTELERQLEELERERQA-RREAEREVQRLQQRLAALEQ---EEAEAREKV 1441

Query: 647  LTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQ-DLQAVCSIVTQRAQGHDPNLSLL 705
               Q+ + Q  P         +L LE  Q     L+ +L+ +   +    +       +L
Sbjct: 1442 THTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVL 1501

Query: 706  LGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIE 741
                  +  +T+ ++Q+   +K  LEE  + +R+++
Sbjct: 1502 SESVQVEKGDTEQEIQR---LKSSLEEESRSKRELD 1534



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 89/439 (20%), Positives = 182/439 (41%), Gaps = 71/439 (16%)

Query: 279  QSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLK 338
            + C+L   + + E+  L+  + Q+Q   +      F       +P     + +    L +
Sbjct: 1263 ERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQE-----DPQTKEEVASLRAKLSE 1317

Query: 339  EKELLIDKQRKHISQLEQKVRESE----------------LQVHSALLGRPAPFGDVCLL 382
            E++  +D +R+  SQ EQ  R+ E                 +    L    + F +   +
Sbjct: 1318 EQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDV 1377

Query: 383  RLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVK 442
             L+++ +    LRA+  +    L R + +LE++L   E E Q  RE+ +   +       
Sbjct: 1378 ELRQIDK----LRAELRR----LQRRRTELERQLEELERERQARREAEREVQRLQQRLAA 1429

Query: 443  KQEERVKGRDKHINNLKKKCQKESEQNR----------EKQQR-------IETLERYLAD 485
             ++E  + R+K  +  K   Q++ +Q R          E+Q R       +ETL R LA 
Sbjct: 1430 LEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAA 1489

Query: 486  LPTLEDHQKQSQQLKDS-ELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEF 544
            L   E   K+   L +S +++  + ++++  L+S LEE     RE ++++  L  R +E 
Sbjct: 1490 LEKAE--VKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSEL 1547

Query: 545  SSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEV 604
                H+ +  + ++    E  ++++E       +LQ    + Q +++   ++ + L    
Sbjct: 1548 EF--HNSKSSKELDFLREENHKLQLER-----QNLQLETRRLQSEINMAATETRDLRNMT 1600

Query: 605  AQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIE-------KNLTLQEHLRQA- 656
              + GT+   R  +  R+  L  L+   K+  ++  +L +       K    + HLR++ 
Sbjct: 1601 VADSGTNHDSRLWSLERE--LDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSI 1658

Query: 657  -----QPGSPPSPDTAQLA 670
                   G   SP+ A  A
Sbjct: 1659 VVIHPDTGRELSPEEAHRA 1677



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 81/400 (20%), Positives = 161/400 (40%), Gaps = 68/400 (17%)

Query: 400  QKTEALSREKIDLEKKLSASEVEVQLIRE---SLKVALQKHSEEVKKQEERVKGRDKHIN 456
            Q+  A++ E    +  L   E  +Q  ++   +L    Q+H  ++++QE  V    +  N
Sbjct: 653  QELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFN 712

Query: 457  NLKKKCQKESEQNREKQQRIETLER-------YLADLPTLEDHQKQSQQLKDSELKSTEL 509
            NL+++ ++ ++  +  +   E   R       +L  +P+ E  +  S    +++LK+ + 
Sbjct: 713  NLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQK- 771

Query: 510  QEKVTELESLLEETQAIC----------REKEIQLESLRQ-------REAEFSSAGHSLQ 552
               + E+ S  +E Q IC          ++ E++ E LR        R +  S       
Sbjct: 772  -NLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQS 830

Query: 553  DKQSVEETSGEGPEVEMESWQKRYDSLQKI-----VEKQQQKMDQLRSQVQSLEQEVAQE 607
                V+E          E +      LQ +     + +QQ +++     +Q    +   E
Sbjct: 831  PATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVE 890

Query: 608  EGTS--QALREEAQRRDSALQQLRTAVKEL----------SVQNQDLIEK--NLTLQEHL 653
            E     + L EE +RR     ++++  +E+          SV  +++++K  +  L+E  
Sbjct: 891  EAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESF 950

Query: 654  RQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQH 713
            +Q Q          QL   L +EL +    L+A+      R  G +  +  +L I     
Sbjct: 951  QQLQRTLAEEQHKNQL---LQEELEALQLQLRALEQ--ETRDGGQEYVVKEVLRI----- 1000

Query: 714  PETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQ 753
                    +PD  + + +EV QLR ++E LR     R A+
Sbjct: 1001 --------EPD--RAQADEVLQLREELEALRRQKGAREAE 1030



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 72/325 (22%), Positives = 126/325 (38%), Gaps = 37/325 (11%)

Query: 463 QKESEQNREKQQRIETLE-RYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTE--LESL 519
           QK +   R  QQR E L+     D   L+  Q  +    D      + QEK     L   
Sbjct: 475 QKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGL--DKVASDLDRQEKAITGILRPP 532

Query: 520 LEETQAIC----REKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGP----EVEMES 571
           LE+ +A+     R K+++  +      E      + + +  ++   G G        +E 
Sbjct: 533 LEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVED 592

Query: 572 WQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQE---VAQEE---GTSQALREEAQRRDSAL 625
             ++Y+ L ++++  Q+K+D      +SL+Q    +A  E        + E ++  DS  
Sbjct: 593 TNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKG 652

Query: 626 QQLRTAVKELSVQNQDL--IEKNL------------TLQEHLRQAQPGSPPSPDTAQLAL 671
           Q+L     EL  Q   L  +E+NL              QEH    +          Q   
Sbjct: 653 QELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFN 712

Query: 672 ELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRK-- 729
            L Q++    Q LQ+  +      +GHD  L  L+ I S +  ET    Q    +K +  
Sbjct: 713 NLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKN 772

Query: 730 -LEEVQQLRRDIEDLRTTMSDRYAQ 753
            L+E+    ++++ +    S +Y Q
Sbjct: 773 LLDEIASREQEVQKI-CANSQQYQQ 796


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 100/428 (23%), Positives = 191/428 (44%), Gaps = 21/428 (4%)

Query: 334  EHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTF 393
            E LL+E+E    +Q     + ++K RE EL+      GR     +    RL+  +RE  F
Sbjct: 1342 EQLLQERE----EQPLRRQERDRKFREEELRHQEQ--GRKFLEEEQ---RLRRQERERKF 1392

Query: 394  LRAQFAQKTEALSREK-IDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRD 452
            L+ +  Q+     RE+ +  ++     E E QL R+      ++  ++V++QE   K  +
Sbjct: 1393 LKEE--QQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE 1450

Query: 453  KHINNLKKKCQKESEQNREKQQRIET-LERYLADLPTLEDHQKQSQQLKDSELKSTELQE 511
            +     +++ +K  E+ +  Q+R E  L R   D   LE+ Q+  +Q +D + +  EL+ 
Sbjct: 1451 EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS 1510

Query: 512  KVTELESLLEETQAIC--REKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEM 569
            +  E + L EE Q     R+++   E  + R  E        +D++  EE        E 
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQ 1570

Query: 570  ESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLR 629
            +  ++  D   ++ E++ ++ +Q R  ++  EQ++ ++EG  Q LR+E  R+    +QL 
Sbjct: 1571 QLSRQERDRKFRLEEQKVRRQEQERKFMED-EQQLRRQEGQQQ-LRQERDRKFREDEQLL 1628

Query: 630  TAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCS 689
               +E  +  Q+   K L  +  LR+ +       D  +   E  Q L    ++ Q    
Sbjct: 1629 QEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEG-EEQQLRRQ 1687

Query: 690  IVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSD 749
               ++ +  +  L            E QL  Q+   ++RK  E +QLR++ E  +    +
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQE---LERKFREEEQLRQETEQEQLRRQE 1744

Query: 750  RYAQDMGE 757
            RY + + E
Sbjct: 1745 RYRKILEE 1752



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 96/383 (25%), Positives = 165/383 (43%), Gaps = 40/383 (10%)

Query: 288 QQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQ 347
           Q+ E  R + EQ+Q   G   H    F    P  E  +   +L       +EK+    ++
Sbjct: 181 QEREERRAEEEQLQSCKG---HETEEF----PDEEQLRRRELLELRRKGREEKQQQRRER 233

Query: 348 RKHISQLEQ----KVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTE 403
           +  + Q E+    + RE+ L+     L    P       R +ELQ E   LR    Q+  
Sbjct: 234 QDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP------QRQRELQEEEEQLRKLERQE-- 285

Query: 404 ALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQ 463
            L RE+ + E++      E QL R+  +   ++  E  ++QE R +  ++    L+++ +
Sbjct: 286 -LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344

Query: 464 KESEQNREKQQRIETLERYL---ADLPTLEDHQKQSQQLKDSELKSTELQ---EKVTELE 517
           +  EQ   ++Q  E  E+ L    +    E   ++ QQL+  +    E Q   E+    E
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404

Query: 518 SLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYD 577
             L   Q + RE++++ E   +RE E     H  + +Q   E   +  + E   W KR +
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQE--EERHEQKHEQERREQRLKREQEERRDWLKREE 462

Query: 578 SLQKIVE---KQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKE 634
             ++  +   KQQ K DQ   + +  E+ +  EE   +  RE+ +RR+   QQLR   +E
Sbjct: 463 ETERHEQERRKQQLKRDQ---EEERRERWLKLEE---EERREQQERRE---QQLRREQEE 513

Query: 635 LSVQNQDLIEKNLTLQEHLRQAQ 657
              Q     E+   LQ+ LR  Q
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQ 536



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 75/333 (22%), Positives = 158/333 (47%), Gaps = 25/333 (7%)

Query: 338 KEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQ 397
           +E++L  ++Q +   QL    RE +L+    L        +  L R Q+L+RE    R Q
Sbjct: 373 REQQLRREQQLRREQQLR---REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 429

Query: 398 FAQKTEALSREKIDLEKKLSASEVEVQLIRESLK--VALQKHSEEVKKQE---ERVKGRD 452
             ++ E    +K + E++    + E +  R+ LK     ++H +E +KQ+   ++ + R 
Sbjct: 430 EEERHE----QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR 485

Query: 453 KHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEK 512
           +    L+++ ++E ++ RE+Q R E  ER    L   E+ ++  Q+L+  +    E +E+
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER 545

Query: 513 VTEL-----ESLLEET---QAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEG 564
             +L     E  LE+    Q + RE+E + + L +RE E        + ++ +E+     
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKRE 605

Query: 565 PEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQS--LEQEVAQEEGTSQALREEAQRRD 622
               +E  ++R   L++   +++++   L+S+ Q    +Q++ +E+   +  R + +  +
Sbjct: 606 EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE 665

Query: 623 SALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQ 655
             L+Q      E   + Q+L E+    QE  R+
Sbjct: 666 ERLEQRLKREHEEERREQELAEEE---QEQARE 695



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 70/325 (21%), Positives = 155/325 (47%), Gaps = 38/325 (11%)

Query: 338 KEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQ 397
           +E++L  +++ +   QL ++ +E E +       +     +  L R Q+L+RE    R Q
Sbjct: 335 REQQLRREQEERREQQLRRE-QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393

Query: 398 FAQKTEALSREK-IDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHIN 456
             ++ + L RE+ +  E++L     E QL RE          +++++++E  +   KH  
Sbjct: 394 QLRREQQLRREQQLRREQQLRR---EQQLRRE----------QQLRREQEEERHEQKHEQ 440

Query: 457 NLKK-KCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTE 515
             ++ + ++E E+ R+  +R E  ER+        + +++ QQLK  +    E +E+  +
Sbjct: 441 ERREQRLKREQEERRDWLKREEETERH--------EQERRKQQLKRDQ--EEERRERWLK 490

Query: 516 LESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKR 575
           LE      Q   RE++++ E   +RE            +Q  EE   +    E +  +++
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLK--------RQEEEERLQQRLRSEQQLRREQ 542

Query: 576 YDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSAL--QQLRTAVK 633
            +  +++++++++K  +   + Q L++E  QEE   Q L+ E +RR   L  +Q     +
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKRE--QEERRDQLLKREEERRQQRLKREQEERLEQ 600

Query: 634 ELSVQNQDLIEKNLTLQEHLRQAQP 658
            L  +  + +E+    ++ L++ +P
Sbjct: 601 RLKREEVERLEQEERREQRLKREEP 625



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 75/347 (21%), Positives = 160/347 (46%), Gaps = 34/347 (9%)

Query: 339  EKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQR---ENTFLR 395
            E++ L ++Q+ H  Q ++K  + E Q+     G+          R Q+  R   E   LR
Sbjct: 1514 ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQ---------RRQDRDRKFREEEQLR 1564

Query: 396  AQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHI 455
             +  ++ + LSR++ D + +L   +V     R+  +    +  +++++QE + + R +  
Sbjct: 1565 QE--REEQQLSRQERDRKFRLEEQKVR----RQEQERKFMEDEQQLRRQEGQQQLRQERD 1618

Query: 456  NNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTE 515
               ++  Q   E+  ++  R E   ++L + P L   +++ Q   D + K  E ++ + E
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678

Query: 516  LESLL---EETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESW 572
             E      +E     RE+E QL   ++RE +F      L+ +Q +E    E  ++  E+ 
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRR-QERERKFLQEEQQLR-RQELERKFREEEQLRQETE 1736

Query: 573  Q---KRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLR 629
            Q   +R +  +KI+E++Q + ++        EQ++ ++E   +   EE  R++   QQLR
Sbjct: 1737 QEQLRRQERYRKILEEEQLRPERE-------EQQLRRQERDRKFREEEQLRQEREEQQLR 1789

Query: 630  TAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQE 676
            +   +   + ++ + +    ++ LR  Q       +  QL LE  ++
Sbjct: 1790 SQESDRKFREEEQLRQERE-EQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 73/303 (24%), Positives = 135/303 (44%), Gaps = 49/303 (16%)

Query: 338 KEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQ 397
           +E++L  +++ +   +L+++  E  LQ                    Q L+ E    R Q
Sbjct: 503 REQQLRREQEERREQRLKRQEEEERLQ--------------------QRLRSEQQLRREQ 542

Query: 398 FAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINN 457
             ++ + L RE+   EK+L     E +L RE      ++  + +K++EER + R      
Sbjct: 543 EERREQLLKREE---EKRLEQERREQRLKREQE----ERRDQLLKREEERRQQR------ 589

Query: 458 LKKKCQKESEQN--REKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTE 515
           LK++ ++  EQ   RE+ +R+E  ER    L   E  +++ QQL  SE +    Q+++  
Sbjct: 590 LKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR 649

Query: 516 LESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKR 575
            +    E +    E+E +LE   +RE E       L +++  +E + E  +  +  WQ +
Sbjct: 650 EQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE--QEQARERIKSRIPKWQWQ 707

Query: 576 YDS-----LQKIVEKQQQKMDQLRSQVQ-------SLEQEVAQEEGTSQALREEAQRRDS 623
            +S       K+  + +++  Q R Q Q         E +  +EE   +  +EE QRRD 
Sbjct: 708 LESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDF 767

Query: 624 ALQ 626
             Q
Sbjct: 768 TWQ 770



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 72/345 (20%), Positives = 157/345 (45%), Gaps = 36/345 (10%)

Query: 318  LPILEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQK-------VRESELQVHSALL 370
            L  LE  + +      + L +E++ L + Q +  SQ +++       + E   +    L 
Sbjct: 831  LQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY 890

Query: 371  GRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESL 430
             +PA         LQE  R+   L  +  ++ +   REK   +++      E QL +E  
Sbjct: 891  AKPA---------LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE 941

Query: 431  KVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLE 490
            ++  ++  +  +++ ER   +DK +   +++   E  + R +Q+R    E+   +   L+
Sbjct: 942  QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER----EKKYREEEELQ 997

Query: 491  DHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHS 550
              ++Q  + +  + +  E + +  + + L +E + + RE E +   L++RE ++      
Sbjct: 998  QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE-EREKRRLQERERQYREEEEL 1056

Query: 551  LQDKQSVEETSGEGPEV----EMESWQKRYDSLQK-----IVEKQQQKMDQLRSQVQSLE 601
             Q++   E+  GE  E     E+E   ++ + LQ+     + E+ +++  Q R +    E
Sbjct: 1057 QQEE---EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE 1113

Query: 602  QEVAQEEGTSQALREEAQ-RRDSALQQLRTAVKELSVQNQDLIEK 645
            +E+ QEE   Q LREE + RR   L++     +E+  + + L+ +
Sbjct: 1114 EELQQEE--EQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 88/421 (20%), Positives = 184/421 (43%), Gaps = 77/421 (18%)

Query: 333 NEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQE-LQREN 391
           +E  L+ +ELL + +RK   + +Q+ RE + +V      +     +  L + +E LQ E 
Sbjct: 206 DEEQLRRRELL-ELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264

Query: 392 TFLRAQFAQKTEALSR-EKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKG 450
              + +  ++ E L + E+ +L ++    E + Q +R   ++  ++  E  ++QEER + 
Sbjct: 265 PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324

Query: 451 RDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQ 510
           +++         +++ E+ RE+Q R E  ER    L   ++ +++ QQL+  +    E +
Sbjct: 325 QER---------REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ--EEERR 373

Query: 511 EKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEME 570
           E+    E  L   Q + RE++++ E   +RE +        +++Q   E      ++  E
Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ-----QLRRE 428

Query: 571 SWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRT 630
             ++R++  QK   +Q+++  +L+ + +     + +EE T    R E +RR   L++   
Sbjct: 429 QEEERHE--QK--HEQERREQRLKREQEERRDWLKREEETE---RHEQERRKQQLKR--- 478

Query: 631 AVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSI 690
                  Q ++  E+ L L+E  R+ Q       +  +  L   QE              
Sbjct: 479 ------DQEEERRERWLKLEEEERREQQ------ERREQQLRREQE-------------- 512

Query: 691 VTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDV-IKRKLEEVQQLRRDIEDLRTTMSD 749
                                +  E +L  Q+ +  ++++L   QQLRR+ E+ R  +  
Sbjct: 513 ---------------------ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551

Query: 750 R 750
           R
Sbjct: 552 R 552



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 77/344 (22%), Positives = 154/344 (44%), Gaps = 51/344 (14%)

Query: 334  EHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTF 393
            E LL+E+E    +Q+ H  + ++K  E E Q                 LR QE  R+   
Sbjct: 1467 EQLLQERE----EQQLHRQERDRKFLEEEQQ-----------------LRRQERDRK--- 1502

Query: 394  LRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDK 453
             R Q  +  E   R+ ++ E++L   + + + ++E  ++  Q+  ++ ++  +R K R++
Sbjct: 1503 FREQELRSQEP-ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR-KFREE 1560

Query: 454  HINNLKKKCQKESEQNREKQQRIETLE--------RYLADLPTLEDHQKQSQQLKDSELK 505
                 +++ Q+ S Q R+++ R+E  +        +++ D   L   + Q Q  ++ + K
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK 1620

Query: 506  STELQEKVTELES------------LLEETQAICREKEIQLESLRQREAEFSSAGHSLQD 553
              E ++ + E E             L EE Q   +E+E QL     R+ +F      LQ+
Sbjct: 1621 FREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR--HDRDRKFREEEQLLQE 1678

Query: 554  --KQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTS 611
              +Q +     +    E E   +R +  +K ++++QQ   Q   +    E+++ QE    
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738

Query: 612  QALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQ 655
            Q  R+E  R+    +QLR   +E  ++ Q+  ++    +E LRQ
Sbjct: 1739 QLRRQERYRKILEEEQLRPEREEQQLRRQER-DRKFREEEQLRQ 1781



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 65/285 (22%), Positives = 128/285 (44%), Gaps = 22/285 (7%)

Query: 381 LLRLQELQRENTFLRAQFAQKTEA-LSREKIDLEKKLSASEVEVQLIRESLKVALQKHS- 438
           L R Q+ +RE    R +  ++ E  L RE  +  ++   +E E +  RE +K  + K   
Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQW 706

Query: 439 ---EEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQ 495
               E   ++ +V  R +     +++ Q++ E+ R ++  ++  E   A     E+ Q++
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRR-QEQEEKRRRRESELQWQEEERAHRQQQEEEQRR 765

Query: 496 SQQLK-DSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEF-SSAGHSLQD 553
               +  +E KS   +++++    L E+     RE++++ E  +QRE  F        Q 
Sbjct: 766 DFTWQWQAEEKSERGRQRLSARPPLREQ-----RERQLRAEERQQREQRFLPEEEEKEQR 820

Query: 554 KQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQ---QQKMDQLRSQVQSLEQEVAQEEGT 610
           ++   E   E   +E E   +R +  Q++ E++   Q+  ++ RSQ Q  +Q+   +   
Sbjct: 821 RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ--- 877

Query: 611 SQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQ 655
              L EE +RR   L       ++L  + Q L E+   LQ   R+
Sbjct: 878 ---LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE 919



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 92/402 (22%), Positives = 158/402 (39%), Gaps = 58/402 (14%)

Query: 387 LQRE-NTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQL----IRESLKVALQKHSEEV 441
           L+RE    LR     KT  L  E +DL+        E  L    + ++   AL + +   
Sbjct: 37  LEREFGAVLRRPHDPKTVDLILELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLD 96

Query: 442 KKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQ--- 498
           +++  R  G++  + + +++         E Q+R E  +R L + P     QK+ +Q   
Sbjct: 97  EEKRARCDGKESLLQDRRQE---------EDQRRFEPRDRQLEEEPGQRRRQKRQEQERE 147

Query: 499 --------LKDSELKSTELQEKVTEL----ESLLEETQAICREKEIQL------------ 534
                    K   L+  + Q +  EL    +   E  +    E+++Q             
Sbjct: 148 LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE 207

Query: 535 ESLRQRE-AEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQL 593
           E LR+RE  E    G   + +Q  E       E E + W+KR   L+K  EK Q++  Q 
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267

Query: 594 RSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHL 653
           + ++Q  E+++ + E   Q LR E Q  +   Q+LR   +    Q ++  E+    QE  
Sbjct: 268 QRELQEEEEQLRKLE--RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ----QEER 321

Query: 654 RQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQH 713
           R+ Q       +  +  L   QE     Q          +R Q  +     L      + 
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQ---------LRREQEEERREQQLRREQEEER 372

Query: 714 PETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDM 755
            E QL  ++    +++L   QQLRR+ + LR     R  Q +
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRRE-QQLRREQQLRREQQL 413



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 76/341 (22%), Positives = 157/341 (46%), Gaps = 40/341 (11%)

Query: 340 KELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRE--NTFLRAQ 397
           KE L+  +R+   Q   + R+ +L+       R          + QE +RE      +++
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQ---------KRQEQERELAEGEEQSE 156

Query: 398 FAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQK---HSEEVKKQEERVKGRDKH 454
             ++ E   R++ D E      E + +  R + +  LQ    H  E    EE+++ R+  
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE-- 214

Query: 455 INNLKKKCQKESEQNR-EKQQRI------------ETLERYLADLPTLEDHQKQSQ-QLK 500
           +  L++K ++E +Q R E+Q R+            ET+ R   +    E+ Q+Q + Q +
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE 274

Query: 501 DSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEET 560
           + +L+  E QE   E +   ++ Q + RE++++ +   +R  +        + ++  EE 
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER 334

Query: 561 SGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSL-EQEVAQEEGT---SQALRE 616
             +  ++  E  ++R   L++  E+++++    R Q +   EQ++ +E+      Q  RE
Sbjct: 335 REQ--QLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRRE 392

Query: 617 EAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 657
           +  RR+   QQLR   ++L  + Q   E+ L  ++ LR+ Q
Sbjct: 393 QQLRRE---QQLRRE-QQLRREQQLRREQQLRREQQLRREQ 429



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 75/355 (21%), Positives = 145/355 (40%), Gaps = 58/355 (16%)

Query: 338  KEKELLIDKQRKHISQLEQKV--RESELQVHSALL------GRPAPFGDVCLLRLQELQR 389
            KE++LL ++  K   Q  +K    E ELQ     L       R     +    +  ELQ+
Sbjct: 969  KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ 1028

Query: 390  ENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQL-----IRESLKVALQKHSEEVKKQ 444
            E   L  +  +K     RE+   E++    E E  L      R   ++  Q   EE  +Q
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQ 1088

Query: 445  EE----RVKGRDKHINNLKKKCQKESEQNREKQQ---------RIETLERYLADLPTLED 491
            EE    R +   +     +++C++E E  +E++Q         R + LER   +   ++ 
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ 1148

Query: 492  HQKQSQQLKDSELKSTELQEKVTELESLLEETQAICR----------------EKEIQLE 535
             ++Q  + +  + +  EL+ +  E E L +E + + R                E+E+Q +
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ 1208

Query: 536  SLRQR----------------EAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSL 579
              +QR                E E +   + +  K    E   +  + ++   Q + D  
Sbjct: 1209 KRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQ 1268

Query: 580  QKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKE 634
              + E+Q++  +Q R + Q  ++   +EE   +  ++EA+RRD   Q+ +  ++E
Sbjct: 1269 HLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLRE 1323



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 77/315 (24%), Positives = 140/315 (44%), Gaps = 43/315 (13%)

Query: 333  NEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENT 392
            +E LL+E+E    +Q+ H  + ++K  E E Q                 LR QE +++  
Sbjct: 1624 DEQLLQERE----EQQLHRQERDRKFLEEEPQ-----------------LRRQEREQQLR 1662

Query: 393  FLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRD 452
              R +  ++ E L +E    E++L   E + +   E  ++  Q+   +  ++E++++ ++
Sbjct: 1663 HDRDRKFREEEQLLQE--GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQE 1720

Query: 453  KHINNLKKKCQKESEQNRE-KQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQE 511
                 L++K ++E +  +E +Q+++   ERY      LE+ Q + ++ ++ +L+  E   
Sbjct: 1721 -----LERKFREEEQLRQETEQEQLRRQERYRK---ILEEEQLRPER-EEQQLRRQERDR 1771

Query: 512  KVTELESLL---EETQAICREKEIQL---ESLRQREAEFSSAGHSLQDKQSVEETSGEGP 565
            K  E E L    EE Q   +E + +    E LRQ   E          K   EE   +  
Sbjct: 1772 KFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLE 1831

Query: 566  EVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQE--EGTSQALREEAQRRDS 623
            E E    Q+R    Q   E+Q    ++ R + Q L QE  Q+  +   + LREE  RR  
Sbjct: 1832 EQEQRLRQER--DRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQ 1889

Query: 624  ALQQLRTAVKELSVQ 638
              +Q    V E+  Q
Sbjct: 1890 KEEQRHRQVGEIKSQ 1904



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 82/349 (23%), Positives = 154/349 (44%), Gaps = 58/349 (16%)

Query: 338  KEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQ-ELQRENTFLRA 396
            +E++LL ++Q K   + E++ RE E         R         L+ Q E ++EN    A
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN----A 1234

Query: 397  QFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERV-KGRDKHI 455
                K     RE     ++L  S++  +  ++ L+  L +  E  ++QE R  + RD+H 
Sbjct: 1235 VRDNKVYCKGRENEQF-RQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHF 1293

Query: 456  ---NNLKKKCQKES---------------EQNREKQQRIETLERYLADLPTLEDHQKQS- 496
                 L+++ QKE+               E+  EK++R ET  ++  +   L++ ++Q  
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353

Query: 497  -QQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQ 555
             +Q +D + +  EL+ +  +    LEE Q + R+         +RE +F      L+++Q
Sbjct: 1354 RRQERDRKFREEELRHQ-EQGRKFLEEEQRLRRQ---------ERERKF------LKEEQ 1397

Query: 556  SVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQ-VQSLEQEVAQEE------ 608
             +          +    Q R D  +K  E++QQ   Q R +  +  EQ+V ++E      
Sbjct: 1398 QLR--------CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFL 1449

Query: 609  GTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 657
               Q LR+E  R+    +QL    +E  +  Q+   K L  ++ LR+ +
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE 1498



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 75/327 (22%), Positives = 145/327 (44%), Gaps = 40/327 (12%)

Query: 352  SQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKI- 410
            SQL  +  + +LQ    LLG           R +E +R     R +   + E L RE+  
Sbjct: 1256 SQLRDRQSQQDLQ---HLLGEQQE-------RDREQERRRWQQRDRHFPEEEQLEREEQK 1305

Query: 411  DLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEE------------RVKGRDKHINNL 458
            + +++   S+ E QL+RE  +   ++   + K +EE            R + RD+     
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREE 1365

Query: 459  KKKCQKESEQNREKQQRIETLER---YLADLPTLEDHQKQSQQLKDSELKSTELQEKVTE 515
            + + Q++  +  E++QR+   ER   +L +   L   +++ Q  +D + K  E +++++ 
Sbjct: 1366 ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR 1425

Query: 516  LESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQ-K 574
                 +E     RE+E Q+   ++RE +F      L+ ++  +    E    E E  Q  
Sbjct: 1426 -----QERDRKFREEEQQVRR-QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479

Query: 575  RYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQ------RRDSALQQL 628
            R +  +K +E++QQ   Q R + +  EQE+  +E   + L EE Q      +R    ++ 
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDR-KFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQ 1538

Query: 629  RTAVKELSVQNQDLIEKNLTLQEHLRQ 655
            +   +E   Q +   ++    +E LRQ
Sbjct: 1539 QLRRQERGQQRRQDRDRKFREEEQLRQ 1565



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 60/271 (22%), Positives = 122/271 (45%), Gaps = 38/271 (14%)

Query: 382 LRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEV 441
           L+L+E +R     R Q  ++ + L RE+ +  ++    + E + +++ L+   Q   E+ 
Sbjct: 489 LKLEEEER-----REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE 543

Query: 442 KKQEERVKGRDKHINNLKKKCQKESEQNR------------------EKQQRI-----ET 478
           +++E+ +K  ++      K+ ++E  + R                   +QQR+     E 
Sbjct: 544 ERREQLLKREEE------KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597

Query: 479 LERYL--ADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLES 536
           LE+ L   ++  LE  +++ Q+LK  E +    Q+ +   E      Q + RE++ + E 
Sbjct: 598 LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657

Query: 537 LRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDS-LQKIVEKQQQKMDQLRS 595
             +RE E       L+ +   E    E  E E E  ++R  S + K   + + + D  +S
Sbjct: 658 RLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQS 717

Query: 596 QVQSLEQEVAQEEGTSQALREEAQRRDSALQ 626
           +V S  ++  + +   Q   E+ +RR+S LQ
Sbjct: 718 KVYSRPRK-QEGQRRRQEQEEKRRRRESELQ 747



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 55/227 (24%), Positives = 105/227 (46%), Gaps = 27/227 (11%)

Query: 435  QKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQK 494
            Q  +EE +++E+R               ++E EQ R +++  E   ++L +   L+  ++
Sbjct: 797  QLRAEERQQREQRFLPE-----------EEEKEQRRRQRREREKELQFLEEEEQLQ-RRE 844

Query: 495  QSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDK 554
            ++QQL++ E    E QE+    E   ++      +   QLE  R+R      A  +LQ++
Sbjct: 845  RAQQLQEEEDGLQEDQERRRSQEQRRDQ------KWRWQLEEERKRRRHTLYAKPALQEQ 898

Query: 555  QSVEE--TSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQ 612
               E+     E  E++ E  +KR    Q   E+Q ++ +QL+ + + L +E  + E   +
Sbjct: 899  LRKEQQLLQEEEEELQREEREKRRRQEQ---ERQYREEEQLQQEEEQLLRE--EREKRRR 953

Query: 613  ALREEAQRRDSALQQLRTAV--KELSVQNQDLIEKNLTLQEHLRQAQ 657
              RE   R+D  LQQ    +  +E   + +   EK    +E L+Q +
Sbjct: 954  QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEE 1000



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 66/250 (26%), Positives = 110/250 (44%), Gaps = 23/250 (9%)

Query: 334  EHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQR---E 390
            E LL+E E    +Q+    + ++K RE E Q+      R     +   LR QEL+R   E
Sbjct: 1673 EQLLQEGE----EQQLRRQERDRKFREEEQQLRRQERERKF-LQEEQQLRRQELERKFRE 1727

Query: 391  NTFLRAQFAQKTEALSRE----KIDLEKKLSASEVEVQLIRESLKVALQKHSE---EVKK 443
               LR +  Q  E L R+    KI  E++L     E QL R+      ++  +   E ++
Sbjct: 1728 EEQLRQETEQ--EQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREE 1785

Query: 444  QEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSE 503
            Q+ R +  D+     ++  Q+  EQ    QQR +   R+  +   LE+ +++ +Q +D +
Sbjct: 1786 QQLRSQESDRKFREEEQLRQEREEQQLRPQQR-DGKYRWEEEQLQLEEQEQRLRQERDRQ 1844

Query: 504  LKSTE---LQEKVTELESLL--EETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVE 558
             ++ E    QEK    E  L  EE Q   +E+E +L     R  +     H    +   +
Sbjct: 1845 YRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904

Query: 559  ETSGEGPEVE 568
            E  G G  +E
Sbjct: 1905 EGKGHGRLLE 1914


>gi|50658071 phosphodiesterase 4D interacting protein isoform 5
           [Homo sapiens]
          Length = 1132

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 89/367 (24%), Positives = 156/367 (42%), Gaps = 28/367 (7%)

Query: 381 LLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEE 440
           LL+ Q+L    T +  Q    +        +L++K+  +E   ++++E L     + S E
Sbjct: 381 LLKQQKLNSHETTITQQSVSDSHLA-----ELQEKIQQTEATNKILQEKLN----EMSYE 431

Query: 441 VKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLK 500
           +K  +E  + +D  I NLK+  +    +  E  Q IE     +A L  +  HQ Q  QL 
Sbjct: 432 LKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREML-HQSQLGQLH 490

Query: 501 DSELKSTELQE-KVTELESLLEETQAICREKEIQL--ESLRQREAEFSSAGHSLQDKQSV 557
            SE  S   Q+  + +L+S L      C + EIQ     +RQ+E + + A   +Q  ++ 
Sbjct: 491 SSEGTSPAQQQVALLDLQSAL-----FCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAA 545

Query: 558 EETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREE 617
              S +  E   +  Q+   +LQ++ E+ Q K  QLR+       E+  +E   Q L   
Sbjct: 546 AHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHS 605

Query: 618 AQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQEL 677
              ++  LQ+ R  ++     ++ L E N  L E LRQ         D A        E 
Sbjct: 606 LSHKEQLLQEFRELLQYRDNSDKTL-EANEMLLEKLRQR------IHDKAVALERAIDEK 658

Query: 678 ASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLR 737
            S L++ +     +    +  D +L  L  + S+     Q       +++ K  EV+QL 
Sbjct: 659 FSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQ---SMESLLRAKGLEVEQLS 715

Query: 738 RDIEDLR 744
              ++L+
Sbjct: 716 TTCQNLQ 722



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 92/434 (21%), Positives = 180/434 (41%), Gaps = 46/434 (10%)

Query: 330 LNSNEHLLKEKELLIDKQRKHISQLEQKVRESEL-QVHSALLGRPAPFGDVCLLRLQELQ 388
           L S E   +E   +I+ Q   +++L + + +S+L Q+HS+    PA    V LL LQ   
Sbjct: 453 LKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQ-QQVALLDLQSA- 510

Query: 389 RENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERV 448
               F      QK + + R+K   E++L+ ++  VQ +  +       H  E +K+    
Sbjct: 511 ---LFCSQLEIQKLQRVVRQK---ERQLADAKQCVQFVEAAA------HESEQQKEASW- 557

Query: 449 KGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTE 508
               KH   L+K  Q+  E+ + K Q++   E             ++  +++  E     
Sbjct: 558 ----KHNQELRKALQQLQEELQNKSQQLRAWEA------------EKYNEIRTQEQNIQH 601

Query: 509 LQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVE 568
           L   ++  E LL+E + + + ++   ++L   E         + DK    E + +     
Sbjct: 602 LNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSA 661

Query: 569 MESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQL 628
           +E  +K    L+  V ++   +++LR  + S E  +   E   +A   E ++  +  Q L
Sbjct: 662 LEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNL 721

Query: 629 RTAVKELSV------QNQDLIEKNLTLQEHLRQAQPGSPPS-------PDTAQLALELHQ 675
           +   +E+        + Q+ I + L    H R  +     +       P  +++A EL Q
Sbjct: 722 QWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQ 781

Query: 676 ELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQK-PDVIKRKLEEVQ 734
            L    + LQ + S   ++   H+  +  LL   S +  E+Q   +K    +  +  E+Q
Sbjct: 782 RLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQ 841

Query: 735 QLRRDIEDLRTTMS 748
            LR+ +    + MS
Sbjct: 842 ALRQYLGGRDSLMS 855



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 82/369 (22%), Positives = 150/369 (40%), Gaps = 44/369 (11%)

Query: 338  KEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPF-GDVCLLRLQELQRENTFLRA 396
            KE+E +I + +  +    ++V +    + + LL +  P   ++     Q LQR+   L+ 
Sbjct: 737  KEQESIIQQLQTSLHDRNKEVED----LSATLLCKLGPGQSEIAEELCQRLQRKERMLQD 792

Query: 397  QFAQKTEALSREKIDLE---KKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDK 453
              + + + +   +++++   + +S  E E Q   E L  AL + + E++   + + GRD 
Sbjct: 793  LLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDS 852

Query: 454  HINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTEL--QE 511
             ++                Q  I   +  +     L     Q      S   ST L  +E
Sbjct: 853  LMS----------------QAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKE 896

Query: 512  KVTELESLLEETQAICR-EKEI-----QLESLRQREAEFSSAGHSLQDKQSVEETSGEGP 565
             V+   S L +   +   EKE+     +LE + ++E E      +LQ   +V+E   +  
Sbjct: 897  DVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQ 956

Query: 566  EVEMESWQKRYDSLQKIVEKQQQK---------MDQLRSQVQSLEQEVAQEEGTSQALRE 616
              +MES  +     + +++  Q +         M++L  +V  L ++VA  E   Q +  
Sbjct: 957  AADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEI-- 1014

Query: 617  EAQRRDSALQQLRTAVKELSVQNQDL-IEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQ 675
               RR   L  L   V E S  N+ L  E+ L        A P S     T Q+ LE  Q
Sbjct: 1015 SGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQ 1074

Query: 676  ELASCLQDL 684
             L S L+++
Sbjct: 1075 VLRSRLEEV 1083



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 70/300 (23%), Positives = 123/300 (41%), Gaps = 49/300 (16%)

Query: 475 RIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQL 534
           R++ +   L     L  H+    Q   S+    ELQEK+ + E+    T  I +EK    
Sbjct: 373 RVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEA----TNKILQEK---- 424

Query: 535 ESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLR 594
             L +   E   A  S Q +    +   E     ++S ++  + L +++E Q   M +LR
Sbjct: 425 --LNEMSYELKCAQESSQKQDGTIQNLKE----TLKSRERETEELYQVIEGQNDTMAKLR 478

Query: 595 SQV-QSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAV--KELSVQNQDLI----EKNL 647
             + QS   ++   EGTS A      ++  AL  L++A+   +L +Q    +    E+ L
Sbjct: 479 EMLHQSQLGQLHSSEGTSPA------QQQVALLDLQSALFCSQLEIQKLQRVVRQKERQL 532

Query: 648 T-LQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQG--------- 697
              ++ ++  +  +  S    + + + +QEL   LQ LQ      +Q+ +          
Sbjct: 533 ADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEI 592

Query: 698 --HDPNLSLLLGIHSAQHPETQLD-----LQKPDVIKRKLEEVQQLRRDIEDLRTTMSDR 750
              + N+  L   HS  H E  L      LQ  D   + LE  + L   +E LR  + D+
Sbjct: 593 RTQEQNIQHL--NHSLSHKEQLLQEFRELLQYRDNSDKTLEANEML---LEKLRQRIHDK 647


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 89/352 (25%), Positives = 169/352 (48%), Gaps = 52/352 (14%)

Query: 411 DLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNR 470
           DL ++ S   +EV  ++  L++ + K+ + +K++ ER++    ++  L+ +  ++ E+N 
Sbjct: 611 DLLEQKSKLTIEVAELQRQLQLEV-KNQQNIKEERERMRA---NLEELRSQHNEKVEENS 666

Query: 471 EKQQRIETLERYLA-DLPTL-------EDHQKQSQQLKD--SEL-------KSTELQEKV 513
             QQR+E  E  L  +L  L       E HQ + + L+D  SE+       K +E +EK 
Sbjct: 667 TLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKG 726

Query: 514 TELESLLE---ETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEME 570
             +E LL+   + Q +   KE Q + LR+RE E ++   +L+++ S  +        EM+
Sbjct: 727 ALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQ-------EMD 779

Query: 571 SWQKRYDS----LQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQ 626
             +++YD+    L++ VE+  + ++ L S+  + EQ+ A  E   + L+EE ++     +
Sbjct: 780 KLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSE 839

Query: 627 QLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQA 686
           +L   V +L  Q +DL       +E L++ +       +    A +  +E  S  + L+ 
Sbjct: 840 ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALEN 899

Query: 687 VCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRR 738
                 + AQG   NLS            TQ   Q  + +K + E+ +QLRR
Sbjct: 900 ----ELEAAQG---NLS----------QTTQEQKQLSEKLKEESEQKEQLRR 934



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 94/386 (24%), Positives = 168/386 (43%), Gaps = 44/386 (11%)

Query: 384  LQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKK 443
            L++ +RE T L+   A K E  S ++ +++K     + E+Q +RES++ A +  + EV  
Sbjct: 753  LRKRERELTALKG--ALKEEVSSHDQ-EMDKLKEQYDAELQALRESVEEATK--NVEVLA 807

Query: 444  QEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSE 503
                   +D+    ++ K  +E  +N + Q R E LER +A L      Q+Q + LK  E
Sbjct: 808  SRSNTSEQDQAGTEMRVKLLQE--ENEKLQGRSEELERRVAQL------QRQIEDLKGDE 859

Query: 504  LKSTELQEKVTELESLLEETQAICREKEIQLESLRQR-EAEFSSAGHSLQDKQSVEETSG 562
             K+ E  +K       LEE     R++E +  S R+  E E  +A  +L   Q+ +E   
Sbjct: 860  AKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNL--SQTTQEQKQ 917

Query: 563  EGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQ--EEGTSQALR----- 615
               +++ ES QK  + L+++  + + +   L   ++ L++E+A   E   +  L      
Sbjct: 918  LSEKLKEESEQK--EQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQL 975

Query: 616  ---EEAQRRDSALQQLRTAVKELSVQNQDLIEKNL-----TLQEHLRQAQPGSPPSPDTA 667
               +E  RR+ A  Q +   K L  +   L    +      ++E LR  Q     +    
Sbjct: 976  DEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKR 1035

Query: 668  QLALELHQELASCLQDLQAVCSIVTQRA----QGHDPNLSLLLGIHSAQHPETQLDLQKP 723
            QL   L Q L     +L+A   +   R+    Q  D    L + +   ++    L     
Sbjct: 1036 QL---LEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLS---- 1088

Query: 724  DVIKRKLEEVQQLRRDIEDLRTTMSD 749
            + I R  E+++QLR ++   R    D
Sbjct: 1089 ERISRSREQMEQLRNELLQERAARQD 1114



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 67/302 (22%), Positives = 133/302 (44%), Gaps = 33/302 (10%)

Query: 382  LRLQELQRENTFLR----------AQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLK 431
            +R++ LQ EN  L+          AQ  ++ E L  ++   ++ L   E E++ + E+L 
Sbjct: 822  MRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALV 881

Query: 432  VALQKHSEEVKKQEERVKGRDKHINNLKKKCQKE---SEQNREKQQRIETLERYLADLP- 487
             A ++  E V  +       +    NL +  Q++   SE+ +E+ ++ E L R   ++  
Sbjct: 882  HARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMEN 941

Query: 488  -------TLEDHQKQSQQLKDSELKST-ELQEKVTELESL----LEETQAICREKEIQLE 535
                   T+E  QK+   + ++   ST ELQ ++ E +      L E Q   +EK ++ E
Sbjct: 942  ERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAE 1001

Query: 536  SLR----QREAEFSSAGHSLQDKQSVEE---TSGEGPEVEMESWQKRYDSLQKIVEKQQQ 588
              R    + + E       L+D Q  ++   T  +  E  ++  +   ++   + + + +
Sbjct: 1002 KSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSR 1061

Query: 589  KMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLT 648
             + Q+  +V  LE E+ +E   S  L E   R    ++QLR  + +     QDL    ++
Sbjct: 1062 LVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKIS 1121

Query: 649  LQ 650
            L+
Sbjct: 1122 LE 1123



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 89/423 (21%), Positives = 182/423 (43%), Gaps = 57/423 (13%)

Query: 338  KEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQ 397
            K KE L  K    I QLE+ +  +  +   A+  R A   +  L   Q    + T  + Q
Sbjct: 861  KAKETL-KKYEGEIRQLEEALVHARKEEKEAVSARRALENE--LEAAQGNLSQTTQEQKQ 917

Query: 398  FAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINN 457
             ++K +  S +K  L +  +  E E   + ++++   ++ ++ V+            ++ 
Sbjct: 918  LSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDE 977

Query: 458  LKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTE-LQEKVTEL 516
             K+K ++E  +  ++Q + +TLE   + L  ++   +   +L + EL+  +  Q++    
Sbjct: 978  YKEKNRRELAE-MQRQLKEKTLEAEKSRLTAMK--MQDEMRLMEEELRDYQRAQDEALTK 1034

Query: 517  ESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRY 576
              LLE+T    ++ E +LE+    + + S     ++DK S         E+E+E  +   
Sbjct: 1035 RQLLEQT---LKDLEYELEAKSHLKDDRSRLVKQMEDKVS-------QLEMELEEERNNS 1084

Query: 577  DSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELS 636
            D L + + + +++M+QLR+++                L+E A R+D    ++      L 
Sbjct: 1085 DLLSERISRSREQMEQLRNEL----------------LQERAARQDLECDKI-----SLE 1123

Query: 637  VQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDL-----------Q 685
             QN+DL  + + L+   R ++ G     + A++A EL   L S  +D            +
Sbjct: 1124 RQNKDLKSRIIHLEGSYRSSKEGLVVQME-ARIA-ELEDRLESEERDRANLQLSNRRLER 1181

Query: 686  AVCSIVTQRAQGH------DPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRD 739
             V  +V Q    H         LSL L     Q  E + ++ + +  K+KL+   + + D
Sbjct: 1182 KVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMD 1241

Query: 740  IED 742
            + +
Sbjct: 1242 MNE 1244



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 70/366 (19%), Positives = 152/366 (41%), Gaps = 28/366 (7%)

Query: 270  SPDTWHPREQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISI 329
            S  T   ++ S +L    +Q E +R    +M+ +   +          +  +  A   S 
Sbjct: 909  SQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTST 968

Query: 330  LNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLR--LQEL 387
            L     L + KE    K R+ +++++++++E  L+   + L       ++ L+   L++ 
Sbjct: 969  LELQNQLDEYKE----KNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDY 1024

Query: 388  QR--ENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIR--ESLKVALQKHSEEVKK 443
            QR  +    + Q  ++T  L   + +LE K    +   +L++  E     L+   EE + 
Sbjct: 1025 QRAQDEALTKRQLLEQT--LKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERN 1082

Query: 444  QEERVKGRDKHINNLKKKCQKESEQNREKQQRIE----TLERYLADLPTLEDHQKQSQQL 499
              + +  R        ++ + E  Q R  +Q +E    +LER   DL +   H + S + 
Sbjct: 1083 NSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRS 1142

Query: 500  KDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEF----SSAGHSLQDKQ 555
                L   +++ ++ ELE  LE  +      ++    L ++  E          SL D++
Sbjct: 1143 SKEGLV-VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQK 1201

Query: 556  S-------VEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEE 608
                      +   E  E E++  +     LQ+ +E+Q    + L+ Q+ S+++++  ++
Sbjct: 1202 DQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKK 1261

Query: 609  GTSQAL 614
              S+ L
Sbjct: 1262 LPSKVL 1267



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 41/170 (24%), Positives = 77/170 (45%), Gaps = 34/170 (20%)

Query: 577 DSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELS 636
           +S  ++ +  +QK  +L  +V  L++++  E    Q ++EE +R  + L++LR+      
Sbjct: 604 NSTSEVKDLLEQK-SKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRS------ 656

Query: 637 VQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQ 696
            Q+ + +E+N TLQ+ L +++              EL + L    Q        V    +
Sbjct: 657 -QHNEKVEENSTLQQRLEESEG-------------ELRKNLEELFQ--------VKMERE 694

Query: 697 GHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRK---LEEVQQLRRDIEDL 743
            H   +  L    S  H E  LD  K    + K   +EE+ Q ++D++DL
Sbjct: 695 QHQTEIRDLQDQLSEMHDE--LDSAKRSEDREKGALIEELLQAKQDLQDL 742


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 103/448 (22%), Positives = 200/448 (44%), Gaps = 69/448 (15%)

Query: 319  PILEPAQWIS-ILNSNEHLLKEKELLI--DKQRKHISQ----LEQKVRESELQVHS---A 368
            P+L+ A+    + N  E   K KE L   + +RK + +    L Q+  + +LQV +   A
Sbjct: 842  PLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADA 901

Query: 369  LLGRPAPFGDVCLLRLQ-ELQRENTFLRAQFAQKTEA-LSREKIDLEKKLSASEVEVQLI 426
            L         +   ++Q E + +    RA+  ++  A L+ +K  LE + S  + ++  +
Sbjct: 902  LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 961

Query: 427  RESL-KVALQKHSEE--VKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYL 483
              +L KV  +KH+ E  VK   E + G D+ I  L K  +K++ Q   +Q          
Sbjct: 962  ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK--EKKALQEAHQQ---------- 1009

Query: 484  ADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAE 543
                TL+D Q +  ++       T+L+++V +LE  LE+ + +C + E    + R+ E +
Sbjct: 1010 ----TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLE---RAKRKLEGD 1062

Query: 544  FSSAGHSLQDKQSVEETSGEG---PEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSL 600
               A  S  D ++ ++   E     E EM + Q + +  Q +  + Q+K+ +L+++++ L
Sbjct: 1063 LKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEEL 1122

Query: 601  EQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGS 660
            E+E+  E    +A R +A++                 Q  DL  +   + E L +A   +
Sbjct: 1123 EEEIEAE----RASRAKAEK-----------------QRSDLSRELEEISERLEEAGGAT 1161

Query: 661  PPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDL 720
                 +AQ+ +   +E      + Q +   + +    H+   + L   H+    E    +
Sbjct: 1162 -----SAQIEMNKKRE-----AEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQI 1211

Query: 721  QKPDVIKRKLE-EVQQLRRDIEDLRTTM 747
                 +K+KLE E  +L+ +I DL + M
Sbjct: 1212 DSLQRVKQKLEKEKSELKMEINDLASNM 1239



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 82/427 (19%), Positives = 178/427 (41%), Gaps = 41/427 (9%)

Query: 337  LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRA 396
            L EK+ ++ +  +      Q++ E + Q+      +           LQ  + +   LR 
Sbjct: 1295 LDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAK-----STLAHALQSARHDCDLLRE 1349

Query: 397  QFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEV----KKQEERVKGRD 452
            Q+ ++ EA    K +L++ +S +  EV   R   +    + +EE+    KK  +R++  +
Sbjct: 1350 QYEEEQEA----KAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1405

Query: 453  KHINNLKKKCQKESEQNREKQQRIETL----ERYLADLPTLEDHQKQSQQLKDSELKSTE 508
            +H+  +  KC    +  +  Q  +E L    ER  A    L+  Q+   ++  +E K  +
Sbjct: 1406 EHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVL-AEWKQ-K 1463

Query: 509  LQEKVTELESLLEETQAICRE----KEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEG 564
             +E   ELE+  +E++++  E    K    ESL   E       +  Q+   + E   EG
Sbjct: 1464 YEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEG 1523

Query: 565  PEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSA 624
                     K    L+K+ ++   +  +L++ ++  E  +  EEG    ++ E  +  S 
Sbjct: 1524 --------GKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSE 1575

Query: 625  LQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDL 684
            + +    + E   +   L   +L + E ++        S +    AL + +++   L ++
Sbjct: 1576 IDR---KIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRND---ALRIKKKMEGDLNEM 1629

Query: 685  QAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQ----LRRDI 740
            +   +   ++A     NL    GI           ++  D +K +L  V++    ++ ++
Sbjct: 1630 EIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEV 1689

Query: 741  EDLRTTM 747
            E+LR ++
Sbjct: 1690 EELRASL 1696



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 85/454 (18%), Positives = 177/454 (38%), Gaps = 77/454 (16%)

Query: 337  LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRA 396
            +++++ L  + +K I +L+ ++ E E ++ +    R          +  +L RE   +  
Sbjct: 1098 IEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAK-----AEKQRSDLSRELEEISE 1152

Query: 397  QFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHS------------------ 438
            +  +   A S + I++ KK    E E Q +R  L+ +  +H                   
Sbjct: 1153 RLEEAGGATSAQ-IEMNKK---REAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELG 1208

Query: 439  ------EEVKKQEERVKGRDK-HINNLKKKCQKESEQNREKQQRIETLERYLADLPTLED 491
                  + VK++ E+ K   K  IN+L    +  S+     ++   TLE  L+++ T E+
Sbjct: 1209 EQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEE 1268

Query: 492  HQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSL 551
             Q++            EL  +   L +   E      EK+  +  L + +  F+      
Sbjct: 1269 EQQR---------LINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFT------ 1313

Query: 552  QDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQ-EEGT 610
               Q +EE      + ++E   K   +L   ++  +   D LR Q +  ++  A+ + G 
Sbjct: 1314 ---QQIEEL-----KRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGM 1365

Query: 611  SQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLA 670
            S+A  E AQ R           +EL    + L ++    +EH+            T Q  
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRL 1425

Query: 671  LELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQK-------- 722
                ++L   ++   A C  + ++ +    N   +L     ++ ETQ +L+         
Sbjct: 1426 QNEVEDLMIDVERSNAACIALDKKQR----NFDKVLAEWKQKYEETQAELEASQKESRSL 1481

Query: 723  -------PDVIKRKLEEVQQLRRDIEDLRTTMSD 749
                    +  +  L+ ++ L+R+ ++L+  +SD
Sbjct: 1482 STELFKVKNAYEESLDHLETLKRENKNLQQEISD 1515



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 94/466 (20%), Positives = 192/466 (41%), Gaps = 86/466 (18%)

Query: 283  LSTCRQQLELIRLQMEQMQLQNGAICHH----PAAFGPSLPILEPAQWISILNSNEHLLK 338
            L+  +Q+ E  + ++E  Q ++ ++         A+  SL  LE     ++   N++L +
Sbjct: 1457 LAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLE-----TLKRENKNLQQ 1511

Query: 339  EKELL---IDKQRKHISQLEQKVRE-----SELQVHSALLGRPAPFGDVCLLRLQ-ELQR 389
            E   L   I +  KHI +LE+  ++     SELQ             +  +LR+Q EL +
Sbjct: 1512 EISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQ 1571

Query: 390  ENTFLRAQFAQKTEALSREKID----LEKKLSASEVEVQLIRESLKVALQKHSEEVKKQE 445
              + +  + A+K E L + K +    +E   S  + E++   ++L++         KK E
Sbjct: 1572 VKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIK--------KKME 1623

Query: 446  ERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELK 505
              +   +  +N+  ++  +     R  Q  ++  + +L D    +D  K+  QL   E +
Sbjct: 1624 GDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKE--QLAMVERR 1681

Query: 506  STELQEKVTELESLLEETQAICREKEIQLESLRQR------------------EAEFSSA 547
            +  +Q +V EL + LE T+   +  E +L    +R                  E + S  
Sbjct: 1682 ANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQI 1741

Query: 548  GHSLQD------------KQSVEETSGEGPEVEMES-----WQKRYDSLQKIVEKQQQKM 590
               ++D            K+++ + +    E++ E       ++   ++++ V+  Q ++
Sbjct: 1742 QGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRL 1801

Query: 591  DQL--------RSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQN--- 639
            D+         + Q+Q LE  V + E   ++ ++        L++    VKEL+ Q    
Sbjct: 1802 DEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEED 1861

Query: 640  -------QDLIEKNLT-LQEHLRQAQPGSPPSPDTAQLALELHQEL 677
                   QDL++K  T ++ + RQA+     S        +L  EL
Sbjct: 1862 RKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHEL 1907



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 47/239 (19%), Positives = 93/239 (38%), Gaps = 61/239 (25%)

Query: 515 ELESLLEETQAICRE--KEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESW 572
           +L  L+  TQAICR     ++   + +R        ++++   +V+             W
Sbjct: 784 KLAQLITRTQAICRGFLMRVEFRKMMERRESIFCIQYNIRAFMNVKHWP----------W 833

Query: 573 QKRYDSLQKIVE--KQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRT 630
            K Y  ++ +++  + +++M  ++ + +  ++E+A+ E                      
Sbjct: 834 MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEA--------------------- 872

Query: 631 AVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSI 690
                  + ++L EK +TL +     Q       D    A E   +L      L+A    
Sbjct: 873 -------KRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKE 925

Query: 691 VTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLE-EVQQLRRDIEDLRTTMS 748
           VT+RA+  +               E   +L      KRKLE E  +L++DI+DL  T++
Sbjct: 926 VTERAEDEE---------------EINAELTAK---KRKLEDECSELKKDIDDLELTLA 966


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 85/352 (24%), Positives = 156/352 (44%), Gaps = 43/352 (12%)

Query: 334  EHLLKEKELLIDKQRKHIS---QLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRE 390
            E +++ +E  +D Q++  S   +L+Q  + SE ++ +    R A   +   LR++E   E
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK--ARQAEAAERSRLRIEE---E 1453

Query: 391  NTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKG 450
               +R Q     EA  R++   E +L A     +   E+ K   Q+ +E +++Q +    
Sbjct: 1454 IRVVRLQL----EATERQRGGAEGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQ 1508

Query: 451  RDKHIN-NLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTEL 509
            R +     L  + + E+E  REKQ+ ++ LE         E   +Q++  +  +++   L
Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ-VAL 1567

Query: 510  QEKVTELESLLEETQAICREKEIQLESLRQRE----AEFSSAGHSLQDKQSVEETSGEGP 565
            +      E+ L+  +A   EK  QLE   Q E    A+          +Q+  E + E  
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627

Query: 566  EVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSAL 625
            E E+E WQ + +             + LR ++Q+  +EVAQ++  +QA  E+ +      
Sbjct: 1628 ERELERWQLKAN-------------EALRLRLQA--EEVAQQKSLAQAEAEKQKEEAERE 1672

Query: 626  QQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQEL 677
             + R   +E +V+ ++L E+ L  Q  L +          TAQ  L   QEL
Sbjct: 1673 ARRRGKAEEQAVRQRELAEQELEKQRQLAEG---------TAQQRLAAEQEL 1715



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 82/336 (24%), Positives = 151/336 (44%), Gaps = 38/336 (11%)

Query: 334  EHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTF 393
            E  L ++  L +K  K   Q  Q+   + L+  + LL +          RLQE + +   
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEA--TRLKAEAELLQQQKELAQEQARRLQEDKEQ--- 2352

Query: 394  LRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDK 453
            +  Q A++T+   R  ++ E++    ++E+    E LK+ + + S    + EE  +   K
Sbjct: 2353 MAQQLAEETQGFQRT-LEAERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408

Query: 454  HINNLKKKCQKESEQNREKQQRIETLE-----------RYLADLPTLE-DHQKQSQQLKD 501
                + +K  +     +EK   ++TLE           R    +  LE + +K  Q+ K 
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468

Query: 502  SELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETS 561
             +LKS E+Q    + E LL+ETQA+ +    + +SL QRE          Q+K  +E+  
Sbjct: 2469 LQLKSEEMQ--TVQQEQLLQETQALQQSFLSEKDSLLQRERFIE------QEKAKLEQL- 2519

Query: 562  GEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQ-VQSLEQEVAQEEGTSQALREEAQR 620
                    +    +   L++  ++QQQ+M+Q R + V S+E+   ++    + +R + + 
Sbjct: 2520 -------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572

Query: 621  RDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQA 656
                 QQ R   + L+ +NQ L E+   L+E  R A
Sbjct: 2573 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2608



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 72/360 (20%), Positives = 161/360 (44%), Gaps = 55/360 (15%)

Query: 324  AQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLR 383
            +Q+I  ++     ++E+E L ++QR      E++ R +E++   A L +     +     
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRA-----EERERLAEVE---AALEKQRQLAEAHAQA 1382

Query: 384  LQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVK- 442
              + +RE   L+ +  ++        +D +++  + + E+Q +R+S +  +Q  + + + 
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442

Query: 443  ------KQEERVK--------------GRDKHINNLKKKCQKESEQNREKQQRIETLERY 482
                  + EE ++              G +  +  L+ + ++   Q R+ Q+  E L R 
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502

Query: 483  LADLPTLEDHQKQSQQLKDSELKSTELQEKV-TELESLLEETQAICREKEIQLES----L 537
            + D         +SQ+ + +E+   EL  +V  E E+  E+ +A+   +E++L++     
Sbjct: 1503 VQD---------ESQRKRQAEV---ELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1550

Query: 538  RQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQV 597
            R R+AE   A    +  Q   ET+    E E++S +  +      +E+  Q+     +Q+
Sbjct: 1551 RLRQAEVERA----RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606

Query: 598  QSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 657
            +   +  AQ++  ++  REEA+R     Q        L +Q +++ +     Q+ L QA+
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-----QKSLAQAE 1661



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 98/450 (21%), Positives = 188/450 (41%), Gaps = 48/450 (10%)

Query: 321  LEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVC 380
            LE  + ++   + + L  E+EL+  +      + ++++ E EL    A L R A      
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL----ARLQREAA---AA 1746

Query: 381  LLRLQELQRENTFLRAQF----AQKTEALSREKIDLEKKLSASEVEVQLIRESLKVA--L 434
              + QEL+ E   +RA+     A K  A    +   EK     E E    RE  + A  L
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1806

Query: 435  QKHSEEVKKQ-----EERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTL 489
            +  +EE K+Q     E+  + R +    L +K     E  R K +    L+   A+   L
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866

Query: 490  ----EDHQKQSQQLKDSELK-STELQEKVTELESLLEETQAICREKEIQLESLRQREAEF 544
                ED   Q ++L++   +   +++E++ +L    +    + R+K +  ++LRQR    
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE--LERQKGLVEDTLRQRRQVE 1924

Query: 545  SSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEV 604
                  L  K S E+ +    E+E+E  + R ++   +  K+Q +++  R +  + E+E 
Sbjct: 1925 EEI---LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981

Query: 605  AQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIE----KNLTLQEHLRQAQPGS 660
             + E   +  +  A   ++A +Q + A++E+      + E    +    QE  RQ Q   
Sbjct: 1982 RRREAEERVQKSLAAEEEAA-RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040

Query: 661  PPSPDTAQLALELH--------QELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQ 712
              +    Q   + H        QEL   LQ  Q+V   +   A+      +       A+
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE------AARRAAEEAE 2094

Query: 713  HPETQLDLQKPDVIKRKLEEVQQLRRDIED 742
                Q + +     +R++EE ++L++  E+
Sbjct: 2095 EARVQAEREAAQ-SRRQVEEAERLKQSAEE 2123



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 91/470 (19%), Positives = 191/470 (40%), Gaps = 64/470 (13%)

Query: 288  QQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQ 347
            +++ ++RLQ+E  + Q G       A G    +   A+        E   ++ +   ++ 
Sbjct: 1452 EEIRVVRLQLEATERQRGG------AEGELQALRARAE------EAEAQKRQAQEEAERL 1499

Query: 348  RKHISQLEQKVRESELQVHSALLGRPAPFGDV--CLLRLQELQRENTFLRAQFAQ-KTEA 404
            R+ +    Q+ R++E+++ S +        +    L  L+EL+ +      +  Q + E 
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1559

Query: 405  LSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQK 464
              + ++ LE    ++E E+Q  R S        +E+  + E  ++     +  L+++ ++
Sbjct: 1560 ARQVQVALETAQRSAEAELQSKRASF-------AEKTAQLERSLQEEHVAVAQLREEAER 1612

Query: 465  ESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQ 524
             ++Q  E ++  E  ER L           +  QLK +E     LQ +    +  L + +
Sbjct: 1613 RAQQQAEAERAREEAEREL-----------ERWQLKANEALRLRLQAEEVAQQKSLAQAE 1661

Query: 525  AICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVE 584
            A  +++E + E+ R+ +AE          +Q+V +      E+E +       + Q++  
Sbjct: 1662 AEKQKEEAEREARRRGKAE----------EQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1711

Query: 585  KQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIE 644
            +Q+  + +LR++ +  EQ+    E     L+ EA       Q+L   + ++  + + L+ 
Sbjct: 1712 EQE--LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769

Query: 645  KNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVC------------SIVT 692
                 +E  R     S  S    +      +ELA     L+A+                 
Sbjct: 1770 SKARAEEESRST---SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1826

Query: 693  QRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIED 742
            QRA+        L  I  A   +T+ ++     +K K  E ++LRR  ED
Sbjct: 1827 QRAEAERVLAEKLAAIGEATRLKTEAEI----ALKEKEAENERLRRLAED 1872



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 95/421 (22%), Positives = 180/421 (42%), Gaps = 55/421 (13%)

Query: 332  SNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPA---PFGDVC-----LLR 383
            S+  L ++K L+ D  R+   Q+E+++   +     A  G+       G +       LR
Sbjct: 1902 SDSELERQKGLVEDTLRQR-RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960

Query: 384  LQELQRENTFLRAQFAQKTEALSREKID-LEKKLSASEVEVQLIRESLKVA--LQKHSEE 440
             +E        + Q A + E   RE  + ++K L+A E   +  + +L+    L+   EE
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020

Query: 441  VKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLK 500
             ++  ER                 E E  R+ Q   E  ++    L   E     + Q K
Sbjct: 2021 ARRLRERA----------------EQESARQLQLAQEAAQK---RLQAEEKAHAFAVQQK 2061

Query: 501  DSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQD----KQS 556
            + EL+ T LQ++ + L+ L  E +A  R  E   E+  Q E E + +   +++    KQS
Sbjct: 2062 EQELQQT-LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120

Query: 557  VEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALRE 616
             EE +    + +  + + R ++ Q+   + Q +   LR +  +  +    ++   Q LR+
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180

Query: 617  EAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQE 676
            +AQ  +  L  LR  ++E   Q      KNL L E L++ +     + + A+   ++ +E
Sbjct: 2181 KAQ-VEQELTTLRLQLEETDHQ------KNL-LDEELQRLK---AEATEAARQRSQVEEE 2229

Query: 677  LASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQ-KPDVIKRKLEEVQQ 735
            L S    ++ +  +   +A+    N +L+L         TQ  LQ + + +K+  EE  +
Sbjct: 2230 LFSVRVQMEELSKL---KARIEAENRALIL----RDKDNTQRFLQEEAEKMKQVAEEAAR 2282

Query: 736  L 736
            L
Sbjct: 2283 L 2283



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 81/386 (20%), Positives = 154/386 (39%), Gaps = 46/386 (11%)

Query: 396  AQFAQKTEALSREKIDLEKKLSASE------VEVQLIRESLKVALQKHSEEVKKQEERVK 449
            AQ   + +    E  D+  +L A E      + + L +E  +   Q+ +E+ K Q E V+
Sbjct: 976  AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE-VE 1034

Query: 450  GRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQ-QLKDSELKSTE 508
            G  K +  L  + +K           +  L       PTL    + +  +L+     S  
Sbjct: 1035 GLGKGVARLSAEAEK-----------VLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1083

Query: 509  LQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVE 568
              EK+  +  ++  TQ          E L++ +A  ++       K S+++   +     
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA---- 1139

Query: 569  MESWQKRYDSL-------QKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRR 621
             E+ Q  +D+L       Q++ E+ QQ+  +   +V+   + VAQ     QA+  +   R
Sbjct: 1140 -EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1198

Query: 622  DSALQQLRTAVKELSVQNQDLIEKNLTLQE-HLRQAQPGSPPSPDTAQLALELHQELASC 680
               L+QL    ++L    +        LQ+   RQ Q  + P  D+  +  +L QE A  
Sbjct: 1199 QRELEQLG---RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA-L 1254

Query: 681  LQDLQ------AVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDV---IKRKLE 731
            L++++        C    ++      +  L L  + AQ        +KP V    +  ++
Sbjct: 1255 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1314

Query: 732  EVQQLRRDIEDLRTTMSDRYAQDMGE 757
            E   LR    +L TT++ +Y + + E
Sbjct: 1315 EYVDLRTHYSEL-TTLTSQYIKFISE 1339


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 85/352 (24%), Positives = 156/352 (44%), Gaps = 43/352 (12%)

Query: 334  EHLLKEKELLIDKQRKHIS---QLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRE 390
            E +++ +E  +D Q++  S   +L+Q  + SE ++ +    R A   +   LR++E   E
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK--ARQAEAAERSRLRIEE---E 1457

Query: 391  NTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKG 450
               +R Q     EA  R++   E +L A     +   E+ K   Q+ +E +++Q +    
Sbjct: 1458 IRVVRLQL----EATERQRGGAEGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQ 1512

Query: 451  RDKHIN-NLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTEL 509
            R +     L  + + E+E  REKQ+ ++ LE         E   +Q++  +  +++   L
Sbjct: 1513 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ-VAL 1571

Query: 510  QEKVTELESLLEETQAICREKEIQLESLRQRE----AEFSSAGHSLQDKQSVEETSGEGP 565
            +      E+ L+  +A   EK  QLE   Q E    A+          +Q+  E + E  
Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1631

Query: 566  EVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSAL 625
            E E+E WQ + +             + LR ++Q+  +EVAQ++  +QA  E+ +      
Sbjct: 1632 ERELERWQLKAN-------------EALRLRLQA--EEVAQQKSLAQAEAEKQKEEAERE 1676

Query: 626  QQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQEL 677
             + R   +E +V+ ++L E+ L  Q  L +          TAQ  L   QEL
Sbjct: 1677 ARRRGKAEEQAVRQRELAEQELEKQRQLAEG---------TAQQRLAAEQEL 1719



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 82/336 (24%), Positives = 151/336 (44%), Gaps = 38/336 (11%)

Query: 334  EHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTF 393
            E  L ++  L +K  K   Q  Q+   + L+  + LL +          RLQE + +   
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEA--TRLKAEAELLQQQKELAQEQARRLQEDKEQ--- 2356

Query: 394  LRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDK 453
            +  Q A++T+   R  ++ E++    ++E+    E LK+ + + S    + EE  +   K
Sbjct: 2357 MAQQLAEETQGFQRT-LEAERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2412

Query: 454  HINNLKKKCQKESEQNREKQQRIETLE-----------RYLADLPTLE-DHQKQSQQLKD 501
                + +K  +     +EK   ++TLE           R    +  LE + +K  Q+ K 
Sbjct: 2413 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2472

Query: 502  SELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETS 561
             +LKS E+Q    + E LL+ETQA+ +    + +SL QRE          Q+K  +E+  
Sbjct: 2473 LQLKSEEMQ--TVQQEQLLQETQALQQSFLSEKDSLLQRERFIE------QEKAKLEQL- 2523

Query: 562  GEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQ-VQSLEQEVAQEEGTSQALREEAQR 620
                    +    +   L++  ++QQQ+M+Q R + V S+E+   ++    + +R + + 
Sbjct: 2524 -------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2576

Query: 621  RDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQA 656
                 QQ R   + L+ +NQ L E+   L+E  R A
Sbjct: 2577 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2612



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 72/360 (20%), Positives = 161/360 (44%), Gaps = 55/360 (15%)

Query: 324  AQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLR 383
            +Q+I  ++     ++E+E L ++QR      E++ R +E++   A L +     +     
Sbjct: 1335 SQYIKFISETLRRMEEEERLAEQQRA-----EERERLAEVE---AALEKQRQLAEAHAQA 1386

Query: 384  LQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVK- 442
              + +RE   L+ +  ++        +D +++  + + E+Q +R+S +  +Q  + + + 
Sbjct: 1387 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446

Query: 443  ------KQEERVK--------------GRDKHINNLKKKCQKESEQNREKQQRIETLERY 482
                  + EE ++              G +  +  L+ + ++   Q R+ Q+  E L R 
Sbjct: 1447 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506

Query: 483  LADLPTLEDHQKQSQQLKDSELKSTELQEKV-TELESLLEETQAICREKEIQLES----L 537
            + D         +SQ+ + +E+   EL  +V  E E+  E+ +A+   +E++L++     
Sbjct: 1507 VQD---------ESQRKRQAEV---ELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1554

Query: 538  RQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQV 597
            R R+AE   A    +  Q   ET+    E E++S +  +      +E+  Q+     +Q+
Sbjct: 1555 RLRQAEVERA----RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1610

Query: 598  QSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 657
            +   +  AQ++  ++  REEA+R     Q        L +Q +++ +     Q+ L QA+
Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-----QKSLAQAE 1665



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 98/450 (21%), Positives = 188/450 (41%), Gaps = 48/450 (10%)

Query: 321  LEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVC 380
            LE  + ++   + + L  E+EL+  +      + ++++ E EL    A L R A      
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL----ARLQREAA---AA 1750

Query: 381  LLRLQELQRENTFLRAQF----AQKTEALSREKIDLEKKLSASEVEVQLIRESLKVA--L 434
              + QEL+ E   +RA+     A K  A    +   EK     E E    RE  + A  L
Sbjct: 1751 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1810

Query: 435  QKHSEEVKKQ-----EERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTL 489
            +  +EE K+Q     E+  + R +    L +K     E  R K +    L+   A+   L
Sbjct: 1811 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1870

Query: 490  ----EDHQKQSQQLKDSELK-STELQEKVTELESLLEETQAICREKEIQLESLRQREAEF 544
                ED   Q ++L++   +   +++E++ +L    +    + R+K +  ++LRQR    
Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE--LERQKGLVEDTLRQRRQVE 1928

Query: 545  SSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEV 604
                  L  K S E+ +    E+E+E  + R ++   +  K+Q +++  R +  + E+E 
Sbjct: 1929 EEI---LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1985

Query: 605  AQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIE----KNLTLQEHLRQAQPGS 660
             + E   +  +  A   ++A +Q + A++E+      + E    +    QE  RQ Q   
Sbjct: 1986 RRREAEERVQKSLAAEEEAA-RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2044

Query: 661  PPSPDTAQLALELH--------QELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQ 712
              +    Q   + H        QEL   LQ  Q+V   +   A+      +       A+
Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE------AARRAAEEAE 2098

Query: 713  HPETQLDLQKPDVIKRKLEEVQQLRRDIED 742
                Q + +     +R++EE ++L++  E+
Sbjct: 2099 EARVQAEREAAQ-SRRQVEEAERLKQSAEE 2127



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 91/470 (19%), Positives = 191/470 (40%), Gaps = 64/470 (13%)

Query: 288  QQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQ 347
            +++ ++RLQ+E  + Q G       A G    +   A+        E   ++ +   ++ 
Sbjct: 1456 EEIRVVRLQLEATERQRGG------AEGELQALRARAE------EAEAQKRQAQEEAERL 1503

Query: 348  RKHISQLEQKVRESELQVHSALLGRPAPFGDV--CLLRLQELQRENTFLRAQFAQ-KTEA 404
            R+ +    Q+ R++E+++ S +        +    L  L+EL+ +      +  Q + E 
Sbjct: 1504 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1563

Query: 405  LSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQK 464
              + ++ LE    ++E E+Q  R S        +E+  + E  ++     +  L+++ ++
Sbjct: 1564 ARQVQVALETAQRSAEAELQSKRASF-------AEKTAQLERSLQEEHVAVAQLREEAER 1616

Query: 465  ESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQ 524
             ++Q  E ++  E  ER L           +  QLK +E     LQ +    +  L + +
Sbjct: 1617 RAQQQAEAERAREEAEREL-----------ERWQLKANEALRLRLQAEEVAQQKSLAQAE 1665

Query: 525  AICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVE 584
            A  +++E + E+ R+ +AE          +Q+V +      E+E +       + Q++  
Sbjct: 1666 AEKQKEEAEREARRRGKAE----------EQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1715

Query: 585  KQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIE 644
            +Q+  + +LR++ +  EQ+    E     L+ EA       Q+L   + ++  + + L+ 
Sbjct: 1716 EQE--LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1773

Query: 645  KNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVC------------SIVT 692
                 +E  R     S  S    +      +ELA     L+A+                 
Sbjct: 1774 SKARAEEESRST---SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1830

Query: 693  QRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIED 742
            QRA+        L  I  A   +T+ ++     +K K  E ++LRR  ED
Sbjct: 1831 QRAEAERVLAEKLAAIGEATRLKTEAEI----ALKEKEAENERLRRLAED 1876



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 95/421 (22%), Positives = 180/421 (42%), Gaps = 55/421 (13%)

Query: 332  SNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPA---PFGDVC-----LLR 383
            S+  L ++K L+ D  R+   Q+E+++   +     A  G+       G +       LR
Sbjct: 1906 SDSELERQKGLVEDTLRQR-RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964

Query: 384  LQELQRENTFLRAQFAQKTEALSREKID-LEKKLSASEVEVQLIRESLKVA--LQKHSEE 440
             +E        + Q A + E   RE  + ++K L+A E   +  + +L+    L+   EE
Sbjct: 1965 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2024

Query: 441  VKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLK 500
             ++  ER                 E E  R+ Q   E  ++    L   E     + Q K
Sbjct: 2025 ARRLRERA----------------EQESARQLQLAQEAAQK---RLQAEEKAHAFAVQQK 2065

Query: 501  DSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQD----KQS 556
            + EL+ T LQ++ + L+ L  E +A  R  E   E+  Q E E + +   +++    KQS
Sbjct: 2066 EQELQQT-LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2124

Query: 557  VEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALRE 616
             EE +    + +  + + R ++ Q+   + Q +   LR +  +  +    ++   Q LR+
Sbjct: 2125 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184

Query: 617  EAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQE 676
            +AQ  +  L  LR  ++E   Q      KNL L E L++ +     + + A+   ++ +E
Sbjct: 2185 KAQ-VEQELTTLRLQLEETDHQ------KNL-LDEELQRLK---AEATEAARQRSQVEEE 2233

Query: 677  LASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQ-KPDVIKRKLEEVQQ 735
            L S    ++ +  +   +A+    N +L+L         TQ  LQ + + +K+  EE  +
Sbjct: 2234 LFSVRVQMEELSKL---KARIEAENRALIL----RDKDNTQRFLQEEAEKMKQVAEEAAR 2286

Query: 736  L 736
            L
Sbjct: 2287 L 2287



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 81/386 (20%), Positives = 154/386 (39%), Gaps = 46/386 (11%)

Query: 396  AQFAQKTEALSREKIDLEKKLSASE------VEVQLIRESLKVALQKHSEEVKKQEERVK 449
            AQ   + +    E  D+  +L A E      + + L +E  +   Q+ +E+ K Q E V+
Sbjct: 980  AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE-VE 1038

Query: 450  GRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQ-QLKDSELKSTE 508
            G  K +  L  + +K           +  L       PTL    + +  +L+     S  
Sbjct: 1039 GLGKGVARLSAEAEK-----------VLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1087

Query: 509  LQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVE 568
              EK+  +  ++  TQ          E L++ +A  ++       K S+++   +     
Sbjct: 1088 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA---- 1143

Query: 569  MESWQKRYDSL-------QKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRR 621
             E+ Q  +D+L       Q++ E+ QQ+  +   +V+   + VAQ     QA+  +   R
Sbjct: 1144 -EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1202

Query: 622  DSALQQLRTAVKELSVQNQDLIEKNLTLQE-HLRQAQPGSPPSPDTAQLALELHQELASC 680
               L+QL    ++L    +        LQ+   RQ Q  + P  D+  +  +L QE A  
Sbjct: 1203 QRELEQLG---RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA-L 1258

Query: 681  LQDLQ------AVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDV---IKRKLE 731
            L++++        C    ++      +  L L  + AQ        +KP V    +  ++
Sbjct: 1259 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1318

Query: 732  EVQQLRRDIEDLRTTMSDRYAQDMGE 757
            E   LR    +L TT++ +Y + + E
Sbjct: 1319 EYVDLRTHYSEL-TTLTSQYIKFISE 1343


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 85/352 (24%), Positives = 156/352 (44%), Gaps = 43/352 (12%)

Query: 334  EHLLKEKELLIDKQRKHIS---QLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRE 390
            E +++ +E  +D Q++  S   +L+Q  + SE ++ +    R A   +   LR++E   E
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK--ARQAEAAERSRLRIEE---E 1453

Query: 391  NTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKG 450
               +R Q     EA  R++   E +L A     +   E+ K   Q+ +E +++Q +    
Sbjct: 1454 IRVVRLQL----EATERQRGGAEGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQ 1508

Query: 451  RDKHIN-NLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTEL 509
            R +     L  + + E+E  REKQ+ ++ LE         E   +Q++  +  +++   L
Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ-VAL 1567

Query: 510  QEKVTELESLLEETQAICREKEIQLESLRQRE----AEFSSAGHSLQDKQSVEETSGEGP 565
            +      E+ L+  +A   EK  QLE   Q E    A+          +Q+  E + E  
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627

Query: 566  EVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSAL 625
            E E+E WQ + +             + LR ++Q+  +EVAQ++  +QA  E+ +      
Sbjct: 1628 ERELERWQLKAN-------------EALRLRLQA--EEVAQQKSLAQAEAEKQKEEAERE 1672

Query: 626  QQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQEL 677
             + R   +E +V+ ++L E+ L  Q  L +          TAQ  L   QEL
Sbjct: 1673 ARRRGKAEEQAVRQRELAEQELEKQRQLAEG---------TAQQRLAAEQEL 1715



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 82/336 (24%), Positives = 151/336 (44%), Gaps = 38/336 (11%)

Query: 334  EHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTF 393
            E  L ++  L +K  K   Q  Q+   + L+  + LL +          RLQE + +   
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEA--TRLKAEAELLQQQKELAQEQARRLQEDKEQ--- 2352

Query: 394  LRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDK 453
            +  Q A++T+   R  ++ E++    ++E+    E LK+ + + S    + EE  +   K
Sbjct: 2353 MAQQLAEETQGFQRT-LEAERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408

Query: 454  HINNLKKKCQKESEQNREKQQRIETLE-----------RYLADLPTLE-DHQKQSQQLKD 501
                + +K  +     +EK   ++TLE           R    +  LE + +K  Q+ K 
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468

Query: 502  SELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETS 561
             +LKS E+Q    + E LL+ETQA+ +    + +SL QRE          Q+K  +E+  
Sbjct: 2469 LQLKSEEMQ--TVQQEQLLQETQALQQSFLSEKDSLLQRERFIE------QEKAKLEQL- 2519

Query: 562  GEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQ-VQSLEQEVAQEEGTSQALREEAQR 620
                    +    +   L++  ++QQQ+M+Q R + V S+E+   ++    + +R + + 
Sbjct: 2520 -------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572

Query: 621  RDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQA 656
                 QQ R   + L+ +NQ L E+   L+E  R A
Sbjct: 2573 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2608



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 72/360 (20%), Positives = 161/360 (44%), Gaps = 55/360 (15%)

Query: 324  AQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLR 383
            +Q+I  ++     ++E+E L ++QR      E++ R +E++   A L +     +     
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRA-----EERERLAEVE---AALEKQRQLAEAHAQA 1382

Query: 384  LQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVK- 442
              + +RE   L+ +  ++        +D +++  + + E+Q +R+S +  +Q  + + + 
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442

Query: 443  ------KQEERVK--------------GRDKHINNLKKKCQKESEQNREKQQRIETLERY 482
                  + EE ++              G +  +  L+ + ++   Q R+ Q+  E L R 
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502

Query: 483  LADLPTLEDHQKQSQQLKDSELKSTELQEKV-TELESLLEETQAICREKEIQLES----L 537
            + D         +SQ+ + +E+   EL  +V  E E+  E+ +A+   +E++L++     
Sbjct: 1503 VQD---------ESQRKRQAEV---ELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1550

Query: 538  RQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQV 597
            R R+AE   A    +  Q   ET+    E E++S +  +      +E+  Q+     +Q+
Sbjct: 1551 RLRQAEVERA----RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606

Query: 598  QSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 657
            +   +  AQ++  ++  REEA+R     Q        L +Q +++ +     Q+ L QA+
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-----QKSLAQAE 1661



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 98/450 (21%), Positives = 188/450 (41%), Gaps = 48/450 (10%)

Query: 321  LEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVC 380
            LE  + ++   + + L  E+EL+  +      + ++++ E EL    A L R A      
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL----ARLQREAA---AA 1746

Query: 381  LLRLQELQRENTFLRAQF----AQKTEALSREKIDLEKKLSASEVEVQLIRESLKVA--L 434
              + QEL+ E   +RA+     A K  A    +   EK     E E    RE  + A  L
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1806

Query: 435  QKHSEEVKKQ-----EERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTL 489
            +  +EE K+Q     E+  + R +    L +K     E  R K +    L+   A+   L
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866

Query: 490  ----EDHQKQSQQLKDSELK-STELQEKVTELESLLEETQAICREKEIQLESLRQREAEF 544
                ED   Q ++L++   +   +++E++ +L    +    + R+K +  ++LRQR    
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE--LERQKGLVEDTLRQRRQVE 1924

Query: 545  SSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEV 604
                  L  K S E+ +    E+E+E  + R ++   +  K+Q +++  R +  + E+E 
Sbjct: 1925 EEI---LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981

Query: 605  AQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIE----KNLTLQEHLRQAQPGS 660
             + E   +  +  A   ++A +Q + A++E+      + E    +    QE  RQ Q   
Sbjct: 1982 RRREAEERVQKSLAAEEEAA-RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040

Query: 661  PPSPDTAQLALELH--------QELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQ 712
              +    Q   + H        QEL   LQ  Q+V   +   A+      +       A+
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE------AARRAAEEAE 2094

Query: 713  HPETQLDLQKPDVIKRKLEEVQQLRRDIED 742
                Q + +     +R++EE ++L++  E+
Sbjct: 2095 EARVQAEREAAQ-SRRQVEEAERLKQSAEE 2123



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 91/470 (19%), Positives = 191/470 (40%), Gaps = 64/470 (13%)

Query: 288  QQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQ 347
            +++ ++RLQ+E  + Q G       A G    +   A+        E   ++ +   ++ 
Sbjct: 1452 EEIRVVRLQLEATERQRGG------AEGELQALRARAE------EAEAQKRQAQEEAERL 1499

Query: 348  RKHISQLEQKVRESELQVHSALLGRPAPFGDV--CLLRLQELQRENTFLRAQFAQ-KTEA 404
            R+ +    Q+ R++E+++ S +        +    L  L+EL+ +      +  Q + E 
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1559

Query: 405  LSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQK 464
              + ++ LE    ++E E+Q  R S        +E+  + E  ++     +  L+++ ++
Sbjct: 1560 ARQVQVALETAQRSAEAELQSKRASF-------AEKTAQLERSLQEEHVAVAQLREEAER 1612

Query: 465  ESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQ 524
             ++Q  E ++  E  ER L           +  QLK +E     LQ +    +  L + +
Sbjct: 1613 RAQQQAEAERAREEAEREL-----------ERWQLKANEALRLRLQAEEVAQQKSLAQAE 1661

Query: 525  AICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVE 584
            A  +++E + E+ R+ +AE          +Q+V +      E+E +       + Q++  
Sbjct: 1662 AEKQKEEAEREARRRGKAE----------EQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1711

Query: 585  KQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIE 644
            +Q+  + +LR++ +  EQ+    E     L+ EA       Q+L   + ++  + + L+ 
Sbjct: 1712 EQE--LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769

Query: 645  KNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVC------------SIVT 692
                 +E  R     S  S    +      +ELA     L+A+                 
Sbjct: 1770 SKARAEEESRST---SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1826

Query: 693  QRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIED 742
            QRA+        L  I  A   +T+ ++     +K K  E ++LRR  ED
Sbjct: 1827 QRAEAERVLAEKLAAIGEATRLKTEAEI----ALKEKEAENERLRRLAED 1872



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 95/421 (22%), Positives = 180/421 (42%), Gaps = 55/421 (13%)

Query: 332  SNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPA---PFGDVC-----LLR 383
            S+  L ++K L+ D  R+   Q+E+++   +     A  G+       G +       LR
Sbjct: 1902 SDSELERQKGLVEDTLRQR-RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960

Query: 384  LQELQRENTFLRAQFAQKTEALSREKID-LEKKLSASEVEVQLIRESLKVA--LQKHSEE 440
             +E        + Q A + E   RE  + ++K L+A E   +  + +L+    L+   EE
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020

Query: 441  VKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLK 500
             ++  ER                 E E  R+ Q   E  ++    L   E     + Q K
Sbjct: 2021 ARRLRERA----------------EQESARQLQLAQEAAQK---RLQAEEKAHAFAVQQK 2061

Query: 501  DSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQD----KQS 556
            + EL+ T LQ++ + L+ L  E +A  R  E   E+  Q E E + +   +++    KQS
Sbjct: 2062 EQELQQT-LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120

Query: 557  VEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALRE 616
             EE +    + +  + + R ++ Q+   + Q +   LR +  +  +    ++   Q LR+
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180

Query: 617  EAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQE 676
            +AQ  +  L  LR  ++E   Q      KNL L E L++ +     + + A+   ++ +E
Sbjct: 2181 KAQ-VEQELTTLRLQLEETDHQ------KNL-LDEELQRLK---AEATEAARQRSQVEEE 2229

Query: 677  LASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQ-KPDVIKRKLEEVQQ 735
            L S    ++ +  +   +A+    N +L+L         TQ  LQ + + +K+  EE  +
Sbjct: 2230 LFSVRVQMEELSKL---KARIEAENRALIL----RDKDNTQRFLQEEAEKMKQVAEEAAR 2282

Query: 736  L 736
            L
Sbjct: 2283 L 2283



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 81/386 (20%), Positives = 154/386 (39%), Gaps = 46/386 (11%)

Query: 396  AQFAQKTEALSREKIDLEKKLSASE------VEVQLIRESLKVALQKHSEEVKKQEERVK 449
            AQ   + +    E  D+  +L A E      + + L +E  +   Q+ +E+ K Q E V+
Sbjct: 976  AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE-VE 1034

Query: 450  GRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQ-QLKDSELKSTE 508
            G  K +  L  + +K           +  L       PTL    + +  +L+     S  
Sbjct: 1035 GLGKGVARLSAEAEK-----------VLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1083

Query: 509  LQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVE 568
              EK+  +  ++  TQ          E L++ +A  ++       K S+++   +     
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA---- 1139

Query: 569  MESWQKRYDSL-------QKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRR 621
             E+ Q  +D+L       Q++ E+ QQ+  +   +V+   + VAQ     QA+  +   R
Sbjct: 1140 -EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1198

Query: 622  DSALQQLRTAVKELSVQNQDLIEKNLTLQE-HLRQAQPGSPPSPDTAQLALELHQELASC 680
               L+QL    ++L    +        LQ+   RQ Q  + P  D+  +  +L QE A  
Sbjct: 1199 QRELEQLG---RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA-L 1254

Query: 681  LQDLQ------AVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDV---IKRKLE 731
            L++++        C    ++      +  L L  + AQ        +KP V    +  ++
Sbjct: 1255 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1314

Query: 732  EVQQLRRDIEDLRTTMSDRYAQDMGE 757
            E   LR    +L TT++ +Y + + E
Sbjct: 1315 EYVDLRTHYSEL-TTLTSQYIKFISE 1339


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.126    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,084,507
Number of Sequences: 37866
Number of extensions: 1585954
Number of successful extensions: 19527
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 477
Number of HSP's successfully gapped in prelim test: 1222
Number of HSP's that attempted gapping in prelim test: 8175
Number of HSP's gapped (non-prelim): 5873
length of query: 762
length of database: 18,247,518
effective HSP length: 110
effective length of query: 652
effective length of database: 14,082,258
effective search space: 9181632216
effective search space used: 9181632216
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.