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Search of human proteins with 40316937
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40316937 arachidonate 15-lipoxygenase [Homo sapiens]
(662 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40316937 arachidonate 15-lipoxygenase [Homo sapiens] 1360 0.0
gi|154426292 arachidonate 12-lipoxygenase [Homo sapiens] 900 0.0
gi|4502057 arachidonate 5-lipoxygenase [Homo sapiens] 499 e-141
gi|85067501 arachidonate 15-lipoxygenase, second type isoform d ... 458 e-129
gi|182765464 arachidonate lipoxygenase 3 [Homo sapiens] 434 e-121
gi|4502053 arachidonate 12-lipoxygenase, 12R type [Homo sapiens] 423 e-118
gi|85067499 arachidonate 15-lipoxygenase, second type isoform a ... 420 e-117
gi|85067503 arachidonate 15-lipoxygenase, second type isoform b ... 366 e-101
gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo sap... 44 5e-04
gi|224458288 lipoxygenase homology domains 1 isoform 2 [Homo sap... 42 0.002
gi|239754889 PREDICTED: similar to hCG2036697 [Homo sapiens] 40 0.009
gi|239749428 PREDICTED: hypothetical protein XP_002347033 [Homo ... 40 0.009
gi|239743562 PREDICTED: hypothetical protein XP_002342894 [Homo ... 40 0.009
gi|50345997 E1A binding protein p300 [Homo sapiens] 31 3.2
gi|61175248 spermidine/spermine N1-acetyl transferase-like 1 [Ho... 31 3.2
gi|237649113 Rho-related BTB domain containing 2 isoform 3 [Homo... 30 7.1
gi|237649111 Rho-related BTB domain containing 2 isoform 2 [Homo... 30 7.1
gi|237649109 Rho-related BTB domain containing 2 isoform 1 [Homo... 30 7.1
gi|110349786 Alstrom syndrome 1 [Homo sapiens] 30 9.3
gi|224458290 lipoxygenase homology domains 1 isoform 3 [Homo sap... 30 9.3
>gi|40316937 arachidonate 15-lipoxygenase [Homo sapiens]
Length = 662
Score = 1360 bits (3519), Expect = 0.0
Identities = 662/662 (100%), Positives = 662/662 (100%)
Query: 1 MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL 60
MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
Sbjct: 1 MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL 60
Query: 61 LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP 120
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
Sbjct: 61 LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP 120
Query: 121 QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK 180
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
Sbjct: 121 QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK 180
Query: 181 GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV 240
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
Sbjct: 181 GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV 240
Query: 241 LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL 300
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
Sbjct: 241 LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL 300
Query: 301 VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH 360
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
Sbjct: 301 VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH 360
Query: 361 LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST 420
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
Sbjct: 361 LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST 420
Query: 421 GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS 480
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
Sbjct: 421 GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS 480
Query: 481 LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH 540
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
Sbjct: 481 LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH 540
Query: 541 ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ 600
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
Sbjct: 541 ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ 600
Query: 601 PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV 660
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
Sbjct: 601 PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV 660
Query: 661 AI 662
AI
Sbjct: 661 AI 662
>gi|154426292 arachidonate 12-lipoxygenase [Homo sapiens]
Length = 663
Score = 900 bits (2326), Expect = 0.0
Identities = 434/663 (65%), Positives = 528/663 (79%), Gaps = 1/663 (0%)
Query: 1 MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL 60
MG YRIRV+TGA L++GS N+VQLWLVG GEA L +L PARG+E E +V E LG L
Sbjct: 1 MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLL 60
Query: 61 LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP 120
FV+LRK H L DDAWFC+ I+VQGPGA EV FPCYRWV+G +LSLPEGT R G++
Sbjct: 61 QFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNA 120
Query: 121 QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK 180
+FQKHRE+EL++R+++Y W WK+GL L +A + DLP + RF E+KR+DFE +L
Sbjct: 121 LDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKA 180
Query: 181 GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV 240
G ++A+K +L+ W L+DF++IFW +S LAE+VR W++D LF YQFLNGANP++
Sbjct: 181 GALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPML 240
Query: 241 LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL 300
LRRS LP+RLV P GMEELQAQLEKEL+ G+LFEADF LLDGI ANVI +Q+LAAPL
Sbjct: 241 LRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPL 300
Query: 301 VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH 360
VMLK++P+GKL PMVIQ+Q P SP P LFLP+DPP+AWLLAK WVR+SDFQLHE+Q H
Sbjct: 301 VMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYH 360
Query: 361 LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST 420
LL HL+AEVI VATMRCLP +HPIFK +IPH+RYT+EIN RART L+SD GIFD+ +ST
Sbjct: 361 LLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVST 420
Query: 421 GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS 480
GGGGHVQLL++A A LTY S CPPDDLADRGLLG+ + YA DALRLWEII RYVEGIV
Sbjct: 421 GGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVH 480
Query: 481 LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH 540
L Y+ D VK DPELQ WCREITE+GL AQDRGFPVS Q++ Q+CHF+TMC+FTCT QH
Sbjct: 481 LFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQH 540
Query: 541 ASVHLGQLDWYSWVPNAPCTMRLPPPTTK-DATLETVMATLPNFHQASLQMSITWQLGRR 599
A+++ GQLDWY+WVPNAPCTMR+PPPTTK D T+ TVM +LP+ QA LQM+I+W L RR
Sbjct: 541 AAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRR 600
Query: 600 QPVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENS 659
QP MV +G H+E+YFSGP+PKAVL +FR +L L+KEI RN +LD PYEYL+PS +ENS
Sbjct: 601 QPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENS 660
Query: 660 VAI 662
V I
Sbjct: 661 VTI 663
>gi|4502057 arachidonate 5-lipoxygenase [Homo sapiens]
Length = 674
Score = 499 bits (1284), Expect = e-141
Identities = 269/678 (39%), Positives = 409/678 (60%), Gaps = 20/678 (2%)
Query: 1 MGLYRIRVSTGASLYAGSNNQVQLWLVGQHG---EAALGKRLWP--ARGKETELKVEVPE 55
M Y + V+TG+ +AG+++ + L LVG G + L K + RG V V E
Sbjct: 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDE 60
Query: 56 YLGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRT 115
LG + V++ KR +D W+ +I+++ P GD + FPCYRW+ G+ + L +G +
Sbjct: 61 ELGEIQLVRIEKRKYWLNDDWYLKYITLKTPH-GDYIEFPCYRWITGDVEVVLRDGRAKL 119
Query: 116 VGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFE 175
+D + ++HR +ELE R+K YRW W G L++ DLP D +F +K VDF
Sbjct: 120 ARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFV 179
Query: 176 VSLAKGLADLAIKDSLNVL-TCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLN 234
++ +K + +L I +++ + W D DF +IF + ++ERV + W+ED +FGYQFLN
Sbjct: 180 LNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLN 239
Query: 235 GANPVVLRRSAHLPARLVFPPGMEEL----QAQLEKELEGGTLFEADFSLLDGIKANVI- 289
G NPV++RR LP +L M E Q LE+E++ G +F DF LLDGI AN
Sbjct: 240 GCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTD 299
Query: 290 LCSQQHLAAPLVMLKLQPDGKLLPMVIQL-QLPRTGSPPPPLFLPTDPPMAWLLAKCWVR 348
C+ Q LAAP+ +L K++P+ IQL Q+P +P +FLP+D WLLAK WVR
Sbjct: 300 PCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENP---IFLPSDAKYDWLLAKIWVR 356
Query: 349 SSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLV 408
SSDF +H+ +HLLR HL++EV +A R LP++HPIFKL++ H+R+T+ IN +AR L+
Sbjct: 357 SSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLI 416
Query: 409 SDMGIFDQIMSTGGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLG---VKSSFYAQDAL 465
+ G+FD+ +TGGGGHVQ++++A LTY+S C P+ + RG+ + FY D L
Sbjct: 417 CECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGL 476
Query: 466 RLWEIIYRYVEGIVSLHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQV 525
+WE I + +V ++Y+ D V++DPELQ + ++ G++G + GFP S+++R+Q+
Sbjct: 477 LVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQL 536
Query: 526 CHFVTMCIFTCTGQHASVHLGQLDWYSWVPNAPCTMRLPPPTTKD-ATLETVMATLPNFH 584
++T+ IFT + QHA+V+ GQ DW SW+PNAP TMR PPPT K T+E ++ TLP+
Sbjct: 537 SEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRG 596
Query: 585 QASLQMSITWQLGRRQPVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKL 644
++ + W L + Q + +G + EE+F K + +FR+ L A+ I RN K
Sbjct: 597 RSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKK 656
Query: 645 DMPYEYLRPSVVENSVAI 662
+PY YL P + NSVAI
Sbjct: 657 QLPYYYLSPDRIPNSVAI 674
>gi|85067501 arachidonate 15-lipoxygenase, second type isoform d
[Homo sapiens]
Length = 676
Score = 458 bits (1178), Expect = e-129
Identities = 259/686 (37%), Positives = 384/686 (55%), Gaps = 34/686 (4%)
Query: 1 MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAA------LGKRLWPARGKETELKVEVP 54
M +R+RVSTG + AG+ ++V + +VG GE+ LGK G E + +V +P
Sbjct: 1 MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEF--TAGAEEDFQVTLP 58
Query: 55 EYLGPLLFVKLRKRHL-------LKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLS 107
E +G +L +++ K L DAWFC W + P G + FPCY+W+EG G L
Sbjct: 59 EDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGG-HLLFPCYQWLEGAGTLV 117
Query: 108 LPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFL 167
L EGT + D + Q+ R+EEL+ R+++Y+W + G + + DL ++ ++
Sbjct: 118 LQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYS 177
Query: 168 EDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDAL 227
K +F + A++ IK L+ W+ L++ RIF ++ AE + W+EDA
Sbjct: 178 TAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAF 237
Query: 228 FGYQFLNGANPVVLRRSAHLPARL---------VFPPGMEELQAQLEKELEGGTLFEADF 278
F QFLNG NPV++RR +LP V PG LQA+LEK G+LF D
Sbjct: 238 FASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTS-LQAELEK----GSLFLVDH 292
Query: 279 SLLDGIKANVILCSQQHLAAPLVMLKLQPD-GKLLPMVIQLQLPRTGSPPPPLFLPTDPP 337
+L GI+ NVI Q AAP+ +L P G LLP+ IQL +T P P+FLPTD
Sbjct: 293 GILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLS--QTPGPNSPIFLPTDDK 350
Query: 338 MAWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTL 397
WLLAK WVR+++F HE +HLL HL+ EV +AT+R LP HP+FKL+IPH RYTL
Sbjct: 351 WDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTL 410
Query: 398 EINVRARTGLVSDMGIFDQIMSTGGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKS 457
IN AR L+ + D+ G G +L+++ L YS C P+D+ RG+ +
Sbjct: 411 HINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPG 470
Query: 458 SFYAQDALRLWEIIYRYVEGIVSLHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPV 517
+Y D +++W + R+V I+ ++Y +D +V+DD ELQ W REI G + G P
Sbjct: 471 YYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPS 530
Query: 518 SLQARDQVCHFVTMCIFTCTGQHASVHLGQLDWYSWVPNAPCTMRLPPPTTKD-ATLETV 576
SL+ R+ + +VTM IFTC+ +HA+V GQ D +W+PN P +M+LPPPT+K AT E
Sbjct: 531 SLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGF 590
Query: 577 MATLPNFHQASLQMSITWQLGRRQPVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKE 636
+ATLP + + W L + +G + +E+F+ P+ + F+ LA + +
Sbjct: 591 IATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRG 650
Query: 637 IEIRNAKLDMPYEYLRPSVVENSVAI 662
I+ RN L +PY YL P ++ENSV+I
Sbjct: 651 IQERNQGLVLPYTYLDPPLIENSVSI 676
>gi|182765464 arachidonate lipoxygenase 3 [Homo sapiens]
Length = 711
Score = 434 bits (1115), Expect = e-121
Identities = 255/716 (35%), Positives = 376/716 (52%), Gaps = 59/716 (8%)
Query: 1 MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAA------LGKRLWPARGKETELKVEVP 54
M +YR+ V+TG L AG+ + + + LVG GE+ +G+ P G + KV
Sbjct: 1 MAVYRLCVTTGPYLRAGTLDNISVTLVGTCGESPKQRLDRMGRDFAP--GSVQKYKVRCT 58
Query: 55 EYLGPLLFVKLRKRH--LLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGT 112
LG LL +++ K + D+W+C+ I V P G FPCY+W+EG + L GT
Sbjct: 59 AELGELLLLRVHKERYAFFRKDSWYCSRICVTEPD-GSVSHFPCYQWIEGYCTVELRPGT 117
Query: 113 GRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDK-- 170
RT+ +D L HR EL R++ YRW + G + ++ D++F K
Sbjct: 118 ARTICQDSLPLLLDHRTRELRARQECYRWKIYAPGFPCMVDVNSFQEMESDKKFALTKTT 177
Query: 171 -------------------------------RVDFEVSLAKGLADLAIKDSLNVLT---- 195
V + + L AI SL +
Sbjct: 178 TCVDQGDSSGNRYLPGFPMKIDIPSLMYMEPNVRYSATKTISLLFNAIPASLGMKLRGLL 237
Query: 196 ----CWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARL 251
WK LDD IFWC ++ + V + W ED FGYQ+LNG NPV+L + LP++L
Sbjct: 238 DRKGSWKKLDDMQNIFWCHKTFTTKYVTEHWCEDHFFGYQYLNGVNPVMLHCISSLPSKL 297
Query: 252 VFPPGM-EELQAQ---LEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQP 307
M L Q L+ ELE G +F AD+ +L + + QQ++AAPL +L L P
Sbjct: 298 PVTNDMVAPLLGQDTCLQTELERGNIFLADYWILAEAPTHCLNGRQQYVAAPLCLLWLSP 357
Query: 308 DGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSHLLRGHLM 367
G L+P+ IQL +T P P+FLPTD WLLAK WVR+S+F +HE +H L HL+
Sbjct: 358 QGALVPLAIQLS--QTPGPDSPIFLPTDSEWDWLLAKTWVRNSEFLVHENNTHFLCTHLL 415
Query: 368 AEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMSTGGGGHVQ 427
E +AT+R LP HPI+KL++PH RYTL++N AR L++ G+ DQ+ S G G +
Sbjct: 416 CEAFAMATLRQLPLCHPIYKLLLPHTRYTLQVNTIARATLLNPEGLVDQVTSIGRQGLIY 475
Query: 428 LLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVSLHYKTDV 487
L+ A TY++FC PD L RG+L + + Y D L++W I +V IV +Y +D
Sbjct: 476 LMSTGLAHFTYTNFCLPDSLRARGVLAIPNYHYRDDGLKIWAAIESFVSEIVGYYYPSDA 535
Query: 488 AVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQHASVHLGQ 547
+V+ D ELQ W EI G + GFP L ++ F+T IF C+ QHA+V+ GQ
Sbjct: 536 SVQQDSELQAWTGEIFAQAFLGRESSGFPSRLCTPGEMVKFLTAIIFNCSAQHAAVNSGQ 595
Query: 548 LDWYSWVPNAPCTMRLPPPTTK-DATLETVMATLPNFHQASLQMSITWQLGRRQPVMVAV 606
D+ +W+PNAP +MR PPP TK TL+T + TLP + + + + W + + +
Sbjct: 596 HDFGAWMPNAPSSMRQPPPQTKGTTTLKTYLDTLPEVNISCNNLLLFWLVSQEPKDQRPL 655
Query: 607 GQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSVAI 662
G + +E+F+ P+ + F+ LA + ++I+ RN L +PY YL P ++ENSV+I
Sbjct: 656 GTYPDEHFTEEAPRRSIAAFQSRLAQISRDIQERNQGLALPYTYLDPPLIENSVSI 711
>gi|4502053 arachidonate 12-lipoxygenase, 12R type [Homo sapiens]
Length = 701
Score = 423 bits (1088), Expect = e-118
Identities = 240/711 (33%), Positives = 382/711 (53%), Gaps = 59/711 (8%)
Query: 1 MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWP------ARGKETELKVEVP 54
M Y++RV+TG L +G+ + + L +VG GE+ K+L A G + V+ P
Sbjct: 1 MATYKVRVATGTDLLSGTRDSISLTIVGTQGESH--KQLLNHFGRDFATGAVGQYTVQCP 58
Query: 55 EYLGPLLFVKLRKRH--LLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGT 112
+ LG L+ ++L K D W+CN++ + P G FP Y+W++G L+L E T
Sbjct: 59 QDLGELIIIRLHKERYAFFPKDPWYCNYVQICAPN-GRIYHFPAYQWMDGYETLALREAT 117
Query: 113 GRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGL------------------------ 148
G+T +D + +HR+EE+ ++ Y W + GL
Sbjct: 118 GKTTADDSLPVLLEHRKEEIRAKQDFYHWRVFLPGLPSYVHIPSYRPPVRRHRNPNRPEW 177
Query: 149 ---------ILNMAGAKLYDLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKD 199
++N K +L + FL K F V L ++ L+ WK
Sbjct: 178 NGYIPGFPILINFKATKFLNLNLRYSFL--KTASFFVRLGPMALAFKVRGLLDCKHSWKR 235
Query: 200 LDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEE 259
L D +IF +S ++E V + W ED FGYQ+LNG NP ++RR +P + P ++
Sbjct: 236 LKDIRKIFPGKKSVVSEYVAEHWAEDTFFGYQYLNGVNPGLIRRCTRIPDKF---PVTDD 292
Query: 260 LQAQ-------LEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLL 312
+ A L+ ELE G ++ AD+ +++GI + +QH APL +L P+GK++
Sbjct: 293 MVAPFLGEGTCLQAELEKGNIYLADYRIMEGIPTVELSGRKQHHCAPLCLLHFGPEGKMM 352
Query: 313 PMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIV 372
P+ IQL +T P P+FLP+D WLLAK WVR ++F HE +HLL HL+AE
Sbjct: 353 PIAIQLS--QTPGPDCPIFLPSDSEWDWLLAKTWVRYAEFYSHEAIAHLLETHLIAEAFC 410
Query: 373 VATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMSTGGGGHVQLLKQA 432
+A +R LP HP++KL+IPH RYT++IN R L+++ G+ + MS G G ++ +A
Sbjct: 411 LALLRNLPMCHPLYKLLIPHTRYTVQINSIGRAVLLNEGGLSAKGMSLGVEGFAGVMVRA 470
Query: 433 GAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVSLHYKTDVAVKDD 492
+ LTY S P+D +RG+ + +Y D+L +W + +YV I++ +Y +D AV+ D
Sbjct: 471 LSELTYDSLYLPNDFVERGVQDLPGYYYRDDSLAVWNALEKYVTEIITYYYPSDAAVEGD 530
Query: 493 PELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQHASVHLGQLDWYS 552
PELQ+W +EI + L G + GFP L+ ++ +VT+ I+TC+ +HA+V+ GQ+++ +
Sbjct: 531 PELQSWVQEIFKECLLGRESSGFPRCLRTVPELIRYVTIVIYTCSAKHAAVNTGQMEFTA 590
Query: 553 WVPNAPCTMRLPPPTTKD-ATLETVMATLPNFHQASLQMSITWQLGRRQPVMVAVGQHEE 611
W+PN P +MR PP TK TLET M TLP+ + + + W L R +G +
Sbjct: 591 WMPNFPASMRNPPIQTKGLTTLETFMDTLPDVKTTCITLLVLWTLSREPDDRRPLGHFPD 650
Query: 612 EYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSVAI 662
+F P+ ++ FR+ L + +I RN L +PY YL P ++ENS++I
Sbjct: 651 IHFVEEAPRRSIEAFRQRLNQISHDIRQRNKCLPIPYYYLDPVLIENSISI 701
>gi|85067499 arachidonate 15-lipoxygenase, second type isoform a
[Homo sapiens]
Length = 647
Score = 420 bits (1079), Expect = e-117
Identities = 248/688 (36%), Positives = 369/688 (53%), Gaps = 67/688 (9%)
Query: 1 MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAA------LGKRLWPARGKETELKVEVP 54
M +R+RVSTG + AG+ ++V + +VG GE+ LGK G E + +V +P
Sbjct: 1 MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEF--TAGAEEDFQVTLP 58
Query: 55 EYLGPLLFVKLRKRHL-------LKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLS 107
E +G +L +++ K L DAWFC W + P G + FPCY+W+EG G L
Sbjct: 59 EDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGG-HLLFPCYQWLEGAGTLV 117
Query: 108 LPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFL 167
L EGT + D + Q+ R+EEL+ R+++Y+W + G + + DL ++ ++
Sbjct: 118 LQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYS 177
Query: 168 EDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDAL 227
K +F + A++ IK L+ W+ L++ RIF ++ AE + W+EDA
Sbjct: 178 TAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAF 237
Query: 228 FGYQFLNGANPVVLRRSAHLPARL---------VFPPGMEELQAQLEKELEGGTLFEADF 278
F QFLNG NPV++RR +LP V PG LQA+LEK G+LF D
Sbjct: 238 FASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTS-LQAELEK----GSLFLVDH 292
Query: 279 SLLDGIKANVILCSQQHLAAPLVMLKLQPD-GKLLPMVIQLQLPRTGSPPPPLFLPTDPP 337
+L GI+ NVI Q AAP+ +L P G LLP+ IQL +T P P+FLPTD
Sbjct: 293 GILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLS--QTPGPNSPIFLPTDDK 350
Query: 338 MAWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTL 397
WLLAK WVR+++F HE +HLL HL+ EV +AT+R LP HP+FK
Sbjct: 351 WDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFK---------- 400
Query: 398 EINVRARTGLVSDMGIFDQIMSTGGG--GHVQLLKQAGAFLTYSSFCPPDDLADRGLLGV 455
STG G G +L+++ L YS C P+D+ RG+ +
Sbjct: 401 ---------------------STGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDI 439
Query: 456 KSSFYAQDALRLWEIIYRYVEGIVSLHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGF 515
+Y D +++W + R+V I+ ++Y +D +V+DD ELQ W REI G + G
Sbjct: 440 PGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGI 499
Query: 516 PVSLQARDQVCHFVTMCIFTCTGQHASVHLGQLDWYSWVPNAPCTMRLPPPTTKD-ATLE 574
P SL+ R+ + +VTM IFTC+ +HA+V GQ D +W+PN P +M+LPPPT+K AT E
Sbjct: 500 PSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCE 559
Query: 575 TVMATLPNFHQASLQMSITWQLGRRQPVMVAVGQHEEEYFSGPEPKAVLKKFREELAALD 634
+ATLP + + W L + +G + +E+F+ P+ + F+ LA +
Sbjct: 560 GFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQIS 619
Query: 635 KEIEIRNAKLDMPYEYLRPSVVENSVAI 662
+ I+ RN L +PY YL P ++ENSV+I
Sbjct: 620 RGIQERNQGLVLPYTYLDPPLIENSVSI 647
>gi|85067503 arachidonate 15-lipoxygenase, second type isoform b
[Homo sapiens]
Length = 602
Score = 366 bits (940), Expect = e-101
Identities = 232/688 (33%), Positives = 344/688 (50%), Gaps = 112/688 (16%)
Query: 1 MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAA------LGKRLWPARGKETELKVEVP 54
M +R+RVSTG + AG+ ++V + +VG GE+ LGK G E + +V +P
Sbjct: 1 MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEF--TAGAEEDFQVTLP 58
Query: 55 EYLGPLLFVKLRKRHL-------LKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLS 107
E +G +L +++ K L DAWFC W + P G + FPCY+W+EG G L
Sbjct: 59 EDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGG-HLLFPCYQWLEGAGTLV 117
Query: 108 LPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFL 167
L EGT + D + Q+ R+EEL+ R+++Y+W + G + + DL ++ ++
Sbjct: 118 LQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYS 177
Query: 168 EDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDAL 227
K +F + A++ IK L+ W+ L++ RIF ++ AE + W+EDA
Sbjct: 178 TAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAF 237
Query: 228 FGYQFLNGANPVVLRRSAHLPARL---------VFPPGMEELQAQLEKELEGGTLFEADF 278
F QFLNG NPV++RR +LP V PG LQA+LEK G+LF D
Sbjct: 238 FASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTS-LQAELEK----GSLFLVDH 292
Query: 279 SLLDGIKANVILCSQQHLAAPLVMLKLQPD-GKLLPMVIQLQLPRTGSPPPPLFLPTDPP 337
+L GI+ NVI Q AAP+ +L P G LLP+ IQL +T P P+FLPTD
Sbjct: 293 GILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLS--QTPGPNSPIFLPTDDK 350
Query: 338 MAWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTL 397
WLLAK WVR+++F HE +HLL HL+ EV +AT+R LP HP+FK
Sbjct: 351 WDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFK---------- 400
Query: 398 EINVRARTGLVSDMGIFDQIMSTGGG--GHVQLLKQAGAFLTYSSFCPPDDLADRGLLGV 455
STG G G +L+++ L YS C P+D+ RG+ +
Sbjct: 401 ---------------------STGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDI 439
Query: 456 KSSFYAQDALRLWEIIYRYVEGIVSLHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGF 515
+Y D +++W G
Sbjct: 440 PGYYYRDDGMQIW---------------------------------------------GI 454
Query: 516 PVSLQARDQVCHFVTMCIFTCTGQHASVHLGQLDWYSWVPNAPCTMRLPPPTTKD-ATLE 574
P SL+ R+ + +VTM IFTC+ +HA+V GQ D +W+PN P +M+LPPPT+K AT E
Sbjct: 455 PSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCE 514
Query: 575 TVMATLPNFHQASLQMSITWQLGRRQPVMVAVGQHEEEYFSGPEPKAVLKKFREELAALD 634
+ATLP + + W L + +G + +E+F+ P+ + F+ LA +
Sbjct: 515 GFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQIS 574
Query: 635 KEIEIRNAKLDMPYEYLRPSVVENSVAI 662
+ I+ RN L +PY YL P ++ENSV+I
Sbjct: 575 RGIQERNQGLVLPYTYLDPPLIENSVSI 602
>gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo
sapiens]
Length = 2211
Score = 43.9 bits (102), Expect = 5e-04
Identities = 27/102 (26%), Positives = 45/102 (44%), Gaps = 4/102 (3%)
Query: 4 YRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPA----RGKETELKVEVPEYLGP 59
Y + V TG AG+ +++ L + G G GK RG+ +E+ L P
Sbjct: 298 YIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIELAVLLSP 357
Query: 60 LLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVE 101
L V + ++ + WFC + + P G + FPC W++
Sbjct: 358 LSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLD 399
Score = 42.0 bits (97), Expect = 0.002
Identities = 26/106 (24%), Positives = 46/106 (43%), Gaps = 6/106 (5%)
Query: 4 YRIRVSTGASLYAGSNNQVQLWLVGQHGEAAL----GKRLWPARGKETELKVEVPEYL-- 57
+ + + TG AG++ V + L G + + + + + +++ E L
Sbjct: 1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 1236
Query: 58 GPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGN 103
G L V+L + K WF +W+ V P G + FPC RW+ N
Sbjct: 1237 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKN 1282
Score = 36.6 bits (83), Expect = 0.076
Identities = 31/111 (27%), Positives = 50/111 (45%), Gaps = 12/111 (10%)
Query: 1 MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETEL--KVEVPEYLG 58
M Y + V TG AG++ V L L G G+ G+RL T+L K E+
Sbjct: 552 MARYHVTVCTGELEGAGTDANVYLCLFGDVGDT--GERLLYNCRNNTDLFEKGNADEFTI 609
Query: 59 PLLFVKLRKRHLLKDDA------WFCNWISV--QGPGAGDEVRFPCYRWVE 101
+ ++ +R ++ D W+ + + V +G D V FPC RW++
Sbjct: 610 ESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLD 660
Score = 35.4 bits (80), Expect = 0.17
Identities = 29/117 (24%), Positives = 54/117 (46%), Gaps = 15/117 (12%)
Query: 4 YRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWP------ARGKETELKVEVPEYL 57
Y ++V TG + AG++ V + + G++G+ G+R +G E ++ P+ L
Sbjct: 174 YEVKVYTGDVIGAGTDADVFINIFGEYGDT--GERRLENEKDNFEKGAEDRFILDAPD-L 230
Query: 58 GPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGR 114
G L+ + + + WF + I ++ G + FP RW L+L E G+
Sbjct: 231 GQLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRW------LALDEDDGK 281
Score = 32.3 bits (72), Expect = 1.4
Identities = 33/119 (27%), Positives = 51/119 (42%), Gaps = 14/119 (11%)
Query: 3 LYRIRVSTGASLYAGSNNQVQLWL---VGQHGEAALGKRLWPA----RGKETELKVEVPE 55
LY +++ TG AG++ +V + + +G GE LGK RG +E +
Sbjct: 1461 LYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAAD 1520
Query: 56 YLGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGR 114
LG + +KLR + W+ + + DE F C RW LSL + GR
Sbjct: 1521 -LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRW------LSLKKEDGR 1572
Score = 31.2 bits (69), Expect = 3.2
Identities = 31/117 (26%), Positives = 51/117 (43%), Gaps = 17/117 (14%)
Query: 4 YRIRVSTGASLYAGSNNQVQLWLVGQ-HGEAALGKRLWPARGKETELKVEVPEY------ 56
Y ++V TG AG++ V L + G+ +G+ G+R P + + K E +
Sbjct: 1024 YEVQVVTGNVPKAGTDANVYLTIYGEEYGDT--GER--PLKKSDKSNKFEQGQTDTFTIY 1079
Query: 57 ---LGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWV---EGNGVLS 107
LG L +++R + WF + I + FPC RW+ E +G LS
Sbjct: 1080 AIDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLS 1136
Score = 29.6 bits (65), Expect = 9.3
Identities = 21/92 (22%), Positives = 40/92 (43%), Gaps = 5/92 (5%)
Query: 16 AGSNNQVQLWLVGQHG---EAALG-KRLWPARGKETELKVEVPEYLGPLLFVKLRKRHLL 71
AG+N+ + + + GQ G E L W G + ++E+P+ LG +++
Sbjct: 439 AGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIELPD-LGRFYKIRVWHDKRS 497
Query: 72 KDDAWFCNWISVQGPGAGDEVRFPCYRWVEGN 103
W +++ D+ F C RW++ N
Sbjct: 498 SGSGWHLERMTLMNTLNKDKYNFNCNRWLDAN 529
Score = 29.6 bits (65), Expect = 9.3
Identities = 27/104 (25%), Positives = 46/104 (44%), Gaps = 8/104 (7%)
Query: 4 YRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEY-LGPLLF 62
Y + V+TG AG++ V + + G +G+ GKR + + + + L L
Sbjct: 2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDT--GKRELKQKMRNLFERGSTDRFFLETLEL 2151
Query: 63 VKLRKRHLLKDDAWFCN-W----ISVQGPGAGDEVRFPCYRWVE 101
+LRK L D + +C+ W + V G F C RW++
Sbjct: 2152 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLD 2195
>gi|224458288 lipoxygenase homology domains 1 isoform 2 [Homo
sapiens]
Length = 1114
Score = 42.0 bits (97), Expect = 0.002
Identities = 26/106 (24%), Positives = 46/106 (43%), Gaps = 6/106 (5%)
Query: 4 YRIRVSTGASLYAGSNNQVQLWLVGQHGEAAL----GKRLWPARGKETELKVEVPEYL-- 57
+ + + TG AG++ V + L G + + + + + +++ E L
Sbjct: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
Query: 58 GPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGN 103
G L V+L + K WF +W+ V P G + FPC RW+ N
Sbjct: 126 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKN 171
Score = 32.3 bits (72), Expect = 1.4
Identities = 33/119 (27%), Positives = 51/119 (42%), Gaps = 14/119 (11%)
Query: 3 LYRIRVSTGASLYAGSNNQVQLWL---VGQHGEAALGKRLWPA----RGKETELKVEVPE 55
LY +++ TG AG++ +V + + +G GE LGK RG +E +
Sbjct: 350 LYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAAD 409
Query: 56 YLGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGR 114
LG + +KLR + W+ + + DE F C RW LSL + GR
Sbjct: 410 -LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRW------LSLKKEDGR 461
Score = 31.6 bits (70), Expect = 2.4
Identities = 29/115 (25%), Positives = 51/115 (44%), Gaps = 13/115 (11%)
Query: 4 YRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLW--PARGKETELKVEVPEYLGPLL 61
Y + V+TG A ++++ ++L+G+ E + KR+W RGK + V E+ L
Sbjct: 518 YYVSVTTGKHKDAATDSRAFIFLIGEDDERS--KRIWLDYPRGKRGFSRGSVEEFYVAGL 575
Query: 62 FVKLRKRHLLKDD------AWFCNWISVQGPGAGDEVRFPCYRWV---EGNGVLS 107
V + K+ L D W + + P G + C W+ G+G+ S
Sbjct: 576 DVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITS 630
>gi|239754889 PREDICTED: similar to hCG2036697 [Homo sapiens]
Length = 1029
Score = 39.7 bits (91), Expect = 0.009
Identities = 30/100 (30%), Positives = 49/100 (49%), Gaps = 9/100 (9%)
Query: 4 YRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPA-------RGKETELKVEVPEY 56
Y++ V TG +A + ++V L L G+ G++ L ++L+ + RG+ + +V
Sbjct: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGL-RQLYKSNMQVKFQRGQIDKFQVAAVS- 693
Query: 57 LGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPC 96
LG L V LR K W+C + V+ PG E F C
Sbjct: 694 LGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 35.8 bits (81), Expect = 0.13
Identities = 23/105 (21%), Positives = 49/105 (46%), Gaps = 7/105 (6%)
Query: 3 LYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEY------ 56
+Y + V+TG AG+ V + + G+ G+ ++L+ ++ L+ + +
Sbjct: 42 IYEVNVATGELWNAGTVANVYISIHGEKGDTG-SRQLFRSKSSFNFLRGQTDTFFLEAVH 100
Query: 57 LGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVE 101
LG L + + L + WF + + ++ P E F C+RW++
Sbjct: 101 LGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLD 145
>gi|239749428 PREDICTED: hypothetical protein XP_002347033 [Homo
sapiens]
Length = 1029
Score = 39.7 bits (91), Expect = 0.009
Identities = 30/100 (30%), Positives = 49/100 (49%), Gaps = 9/100 (9%)
Query: 4 YRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPA-------RGKETELKVEVPEY 56
Y++ V TG +A + ++V L L G+ G++ L ++L+ + RG+ + +V
Sbjct: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGL-RQLYKSNMQVKFQRGQIDKFQVAAVS- 693
Query: 57 LGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPC 96
LG L V LR K W+C + V+ PG E F C
Sbjct: 694 LGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 35.8 bits (81), Expect = 0.13
Identities = 23/105 (21%), Positives = 49/105 (46%), Gaps = 7/105 (6%)
Query: 3 LYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEY------ 56
+Y + V+TG AG+ V + + G+ G+ ++L+ ++ L+ + +
Sbjct: 42 IYEVNVATGELWNAGTVANVYISIHGEKGDTG-SRQLFRSKSSFNFLRGQTDTFFLEAVH 100
Query: 57 LGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVE 101
LG L + + L + WF + + ++ P E F C+RW++
Sbjct: 101 LGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLD 145
>gi|239743562 PREDICTED: hypothetical protein XP_002342894 [Homo
sapiens]
Length = 1029
Score = 39.7 bits (91), Expect = 0.009
Identities = 30/100 (30%), Positives = 49/100 (49%), Gaps = 9/100 (9%)
Query: 4 YRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPA-------RGKETELKVEVPEY 56
Y++ V TG +A + ++V L L G+ G++ L ++L+ + RG+ + +V
Sbjct: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGL-RQLYKSNMQVKFQRGQIDKFQVAAVS- 693
Query: 57 LGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPC 96
LG L V LR K W+C + V+ PG E F C
Sbjct: 694 LGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 35.8 bits (81), Expect = 0.13
Identities = 23/105 (21%), Positives = 49/105 (46%), Gaps = 7/105 (6%)
Query: 3 LYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEY------ 56
+Y + V+TG AG+ V + + G+ G+ ++L+ ++ L+ + +
Sbjct: 42 IYEVNVATGELWNAGTVANVYISIHGEKGDTG-SRQLFRSKSSFNFLRGQTDTFFLEAVH 100
Query: 57 LGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVE 101
LG L + + L + WF + + ++ P E F C+RW++
Sbjct: 101 LGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLD 145
>gi|50345997 E1A binding protein p300 [Homo sapiens]
Length = 2414
Score = 31.2 bits (69), Expect = 3.2
Identities = 24/72 (33%), Positives = 32/72 (44%), Gaps = 8/72 (11%)
Query: 555 PNAPCTMRLPPPTTKDAT--LE-----TVMATLPNFHQASLQMSITWQLGRRQPVMVAVG 607
P AP M PPP T+ + LE T M P + Q L Q G +P M++V
Sbjct: 1961 PMAPMGMN-PPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMMSVA 2019
Query: 608 QHEEEYFSGPEP 619
QH + P+P
Sbjct: 2020 QHGQPLNMAPQP 2031
>gi|61175248 spermidine/spermine N1-acetyl transferase-like 1 [Homo
sapiens]
Length = 445
Score = 31.2 bits (69), Expect = 3.2
Identities = 14/38 (36%), Positives = 20/38 (52%)
Query: 566 PTTKDATLETVMATLPNFHQASLQMSITWQLGRRQPVM 603
P+ A + LP+ +Q ++ TWQLGR QP M
Sbjct: 107 PSMSQAGMRQSGTNLPDINQPGMKQPGTWQLGRSQPGM 144
>gi|237649113 Rho-related BTB domain containing 2 isoform 3 [Homo
sapiens]
Length = 727
Score = 30.0 bits (66), Expect = 7.1
Identities = 19/61 (31%), Positives = 26/61 (42%), Gaps = 14/61 (22%)
Query: 326 PPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPI 385
PPPP+ + DPP + E +HLL L A+VI+V R H I
Sbjct: 238 PPPPIIVVPDPPSS--------------SEECPAHLLEDPLCADVILVLQERVRIFAHKI 283
Query: 386 F 386
+
Sbjct: 284 Y 284
>gi|237649111 Rho-related BTB domain containing 2 isoform 2 [Homo
sapiens]
Length = 734
Score = 30.0 bits (66), Expect = 7.1
Identities = 19/61 (31%), Positives = 26/61 (42%), Gaps = 14/61 (22%)
Query: 326 PPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPI 385
PPPP+ + DPP + E +HLL L A+VI+V R H I
Sbjct: 245 PPPPIIVVPDPPSS--------------SEECPAHLLEDPLCADVILVLQERVRIFAHKI 290
Query: 386 F 386
+
Sbjct: 291 Y 291
>gi|237649109 Rho-related BTB domain containing 2 isoform 1 [Homo
sapiens]
Length = 749
Score = 30.0 bits (66), Expect = 7.1
Identities = 19/61 (31%), Positives = 26/61 (42%), Gaps = 14/61 (22%)
Query: 326 PPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPI 385
PPPP+ + DPP + E +HLL L A+VI+V R H I
Sbjct: 260 PPPPIIVVPDPPSS--------------SEECPAHLLEDPLCADVILVLQERVRIFAHKI 305
Query: 386 F 386
+
Sbjct: 306 Y 306
>gi|110349786 Alstrom syndrome 1 [Homo sapiens]
Length = 4169
Score = 29.6 bits (65), Expect = 9.3
Identities = 32/145 (22%), Positives = 58/145 (40%), Gaps = 30/145 (20%)
Query: 190 SLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANP-------VVLR 242
S++ L KD D ++ + C R W E+ L ++ A + +
Sbjct: 327 SVDELKIPKDCDRYDDL--CSYMSWKTRKDTQWPENNLADKDQVSVATSFDITDENIATK 384
Query: 243 RSAHLPARLVF------PPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQ--- 293
RS H A + ++ + L K L+G E+D LDG+ N ++CS+
Sbjct: 385 RSDHFDAARSYGQYWTQEDSSKQAETYLTKGLQGKV--ESDVITLDGLNENAVVCSERVA 442
Query: 294 ----------QHLAAPLVMLKLQPD 308
++ ++ L ML++ PD
Sbjct: 443 ELQRKPTRESEYHSSDLRMLRMSPD 467
>gi|224458290 lipoxygenase homology domains 1 isoform 3 [Homo
sapiens]
Length = 512
Score = 29.6 bits (65), Expect = 9.3
Identities = 27/104 (25%), Positives = 46/104 (44%), Gaps = 8/104 (7%)
Query: 4 YRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEY-LGPLLF 62
Y + V+TG AG++ V + + G +G+ GKR + + + + L L
Sbjct: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDT--GKRELKQKMRNLFERGSTDRFFLETLEL 452
Query: 63 VKLRKRHLLKDDAWFCN-W----ISVQGPGAGDEVRFPCYRWVE 101
+LRK L D + +C+ W + V G F C RW++
Sbjct: 453 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLD 496
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,247,549
Number of Sequences: 37866
Number of extensions: 1393237
Number of successful extensions: 4011
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 3937
Number of HSP's gapped (non-prelim): 41
length of query: 662
length of database: 18,247,518
effective HSP length: 109
effective length of query: 553
effective length of database: 14,120,124
effective search space: 7808428572
effective search space used: 7808428572
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.