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Search of human proteins with 40217803
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40217803 leucine rich repeat containing 8 family, member E
[Homo sapiens]
(796 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40217803 leucine rich repeat containing 8 family, member E [H... 1590 0.0
gi|19923729 leucine rich repeat containing 8 family, member C [H... 1008 0.0
gi|62241040 leucine rich repeat containing 8 family, member A [H... 858 0.0
gi|187829877 leucine rich repeat containing 8 family, member A [... 858 0.0
gi|187829871 leucine rich repeat containing 8 family, member A [... 858 0.0
gi|197333706 leucine rich repeat containing 8 family, member D [... 806 0.0
gi|34222199 leucine rich repeat containing 8 family, member D [H... 806 0.0
gi|197333692 leucine rich repeat containing 8 family, member B [... 738 0.0
gi|21245134 leucine rich repeat containing 8 family, member B [H... 738 0.0
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 120 4e-27
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 120 4e-27
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 120 6e-27
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 114 3e-25
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 114 5e-25
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 109 9e-24
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 107 4e-23
gi|45827729 scribble isoform b [Homo sapiens] 106 7e-23
gi|45827731 scribble isoform a [Homo sapiens] 106 7e-23
gi|61742786 leucine rich repeat and death domain containing prot... 105 2e-22
gi|61742784 leucine rich repeat and death domain containing prot... 105 2e-22
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 100 5e-21
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 96 1e-19
gi|238908508 leucine-rich repeat and death domain-containing pro... 95 2e-19
gi|61742782 leucine rich repeat and death domain containing prot... 95 3e-19
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 92 2e-18
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 90 7e-18
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 90 7e-18
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 87 5e-17
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 86 1e-16
gi|4503743 flightless I homolog [Homo sapiens] 85 3e-16
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 1590 bits (4117), Expect = 0.0
Identities = 796/796 (100%), Positives = 796/796 (100%)
Query: 1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPNHEL 60
MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPNHEL
Sbjct: 1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPNHEL 60
Query: 61 QENLSEAPCQQLLPRGIPEQIGALQEVKGLKNNLDLQQYSFINQLCYETALHWYAKYFPY 120
QENLSEAPCQQLLPRGIPEQIGALQEVKGLKNNLDLQQYSFINQLCYETALHWYAKYFPY
Sbjct: 61 QENLSEAPCQQLLPRGIPEQIGALQEVKGLKNNLDLQQYSFINQLCYETALHWYAKYFPY 120
Query: 121 LVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENQKGPAAT 180
LVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENQKGPAAT
Sbjct: 121 LVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENQKGPAAT 180
Query: 181 ERAAATIVAMAGTGPGKAGEGEKEKVLAEPEKVVTEPPVVTLLDKKEGEQAKALFEKVKK 240
ERAAATIVAMAGTGPGKAGEGEKEKVLAEPEKVVTEPPVVTLLDKKEGEQAKALFEKVKK
Sbjct: 181 ERAAATIVAMAGTGPGKAGEGEKEKVLAEPEKVVTEPPVVTLLDKKEGEQAKALFEKVKK 240
Query: 241 FRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVETSEVTGYASFC 300
FRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVETSEVTGYASFC
Sbjct: 241 FRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVETSEVTGYASFC 300
Query: 301 CNHTKAHLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREETGMGDIPDVK 360
CNHTKAHLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREETGMGDIPDVK
Sbjct: 301 CNHTKAHLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREETGMGDIPDVK 360
Query: 361 NDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNAAGRLE 420
NDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNAAGRLE
Sbjct: 361 NDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNAAGRLE 420
Query: 421 LALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQV 480
LALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQV
Sbjct: 421 LALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQV 480
Query: 481 FLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVL 540
FLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVL
Sbjct: 481 FLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVL 540
Query: 541 SLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHA 600
SLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHA
Sbjct: 541 SLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHA 600
Query: 601 VFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYL 660
VFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYL
Sbjct: 601 VFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYL 660
Query: 661 SYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFF 720
SYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFF
Sbjct: 661 SYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFF 720
Query: 721 CRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDT 780
CRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDT
Sbjct: 721 CRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDT 780
Query: 781 LYQGLPAEVRDKMEEE 796
LYQGLPAEVRDKMEEE
Sbjct: 781 LYQGLPAEVRDKMEEE 796
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 1008 bits (2607), Expect = 0.0
Identities = 496/805 (61%), Positives = 625/805 (77%), Gaps = 11/805 (1%)
Query: 1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLP---- 56
MIPV EF+QF+EQQPAF+VLKPWWDV +YL+VAMLMIGVFGCTLQV QDKIICLP
Sbjct: 1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQ 60
Query: 57 ---NHELQENLSEAPCQQL-LPRGIPEQIGALQ-EVKGLKNNLDLQQYSFINQLCYETAL 111
NH N+S+A LP P + E+KGLK +LDLQQYSFINQ+CYE AL
Sbjct: 61 PAQNHSSLSNVSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYERAL 120
Query: 112 HWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSG 171
HWYAKYFPYLV+IHTL+FM+C++FWFKFPG+SSKIEHFISILGKCFDSPWTTRALSEVSG
Sbjct: 121 HWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSG 180
Query: 172 ENQKGPAATERAAATIVAMAGTGPGKAGEGEKEKVLAEPEKVVTEPPVVTLLDKKEGEQA 231
E+ + + + G + K + PEK V + LDKKEGEQA
Sbjct: 181 EDSEEKDNRKNNMNRSNTIQSGPEGSLVNSQSLKSI--PEKFVVDKSTAGALDKKEGEQA 238
Query: 232 KALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVETS 291
KALFEKVKKFR+HVEEGDILY MY+RQTVLKV KFL I+ YN V K+ F V C V+
Sbjct: 239 KALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQ 298
Query: 292 EVTGYASFCCNHTKAHLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREET 351
++TGY +F CNHT AHLFSKL+FCY+ FV IYGLTC+YTLYWLF+R L+EYSF VR+ET
Sbjct: 299 DMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQET 358
Query: 352 GMGDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKL 411
G+ DIPDVKNDFAFMLH+IDQYD LYSKRFAVFLSEVSE++LKQLNLN+EWTP+KLRQKL
Sbjct: 359 GIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKL 418
Query: 412 QRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSP 471
Q NA RLEL L ML GLPDTVFE++E++SL+LE I ++ P ++QL +LQELSL
Sbjct: 419 QTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCS 478
Query: 472 ARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESL 531
++ + FL+++LKV+ VK +++RE+P W++GLR LEEL+L G +++R TLESL
Sbjct: 479 VKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESL 538
Query: 532 RELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVA 591
R+LK LK+LS++SN K+P +V DV+ HLQ++ +HNDG +LV LN+LKK+ L ELELV
Sbjct: 539 RDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVH 598
Query: 592 CGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRK 651
C LERIPHAVFSL +LQELDLK+N+L+SIEEI+SFQH RKL L+LWHN I Y+PEH++K
Sbjct: 599 CDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKK 658
Query: 652 LRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNAL 711
L SLE+L S+NK+E LPS L LC+ +R LD+S+N + +PPE+G+LQ+LQ+ +++ N +
Sbjct: 659 LTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKV 718
Query: 712 EALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLK 771
E+LP+EL+FC+KL+TL +G N LS LSP +G L LS L++KGN E LP ELG+C LK
Sbjct: 719 ESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALK 778
Query: 772 KAGLLVEDTLYQGLPAEVRDKMEEE 796
+AGL+VED L++ LP++VR++M+ E
Sbjct: 779 RAGLVVEDALFETLPSDVREQMKTE 803
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 858 bits (2218), Expect = 0.0
Identities = 430/803 (53%), Positives = 573/803 (71%), Gaps = 11/803 (1%)
Query: 1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPNHEL 60
MIPV E + F + QPA+++LKPWWDV +Y+++ MLMI VFG TLQVTQDK+ICLP +
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60
Query: 61 QENLSEAPCQQLLPRGIPEQIGALQEV--------KGLKNNLDLQQYSFINQLCYETALH 112
++ + G PE + G+K +LD QY++++ +CYE LH
Sbjct: 61 TKDSCNDSFRGWAAPG-PEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLH 119
Query: 113 WYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGE 172
W+AKYFPYLV++HTLIF+ C++FWFKFP TSSK+EHF+SIL KCFDSPWTTRALSE E
Sbjct: 120 WFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVE 179
Query: 173 NQKGPAATERAAATIVAMAGTGPG--KAGEGEKEKVLAEPEKVVTEPPVVTLLDKKEGEQ 230
A + ++ + T +A ++ + E+ + + +LDKKEGEQ
Sbjct: 180 ESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQ 239
Query: 231 AKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVET 290
AKALFEKVKKFR HVEEGDI+Y +Y+RQT++KV KF+ I+ Y + YV I F V C V+
Sbjct: 240 AKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDI 299
Query: 291 SEVTGYASFCCNHTKAHLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREE 350
+TGY ++ C H A LF LA YIS V YGL C+YTL+W+ R LK+YSF S+REE
Sbjct: 300 ESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREE 359
Query: 351 TGMGDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQK 410
+ DIPDVKNDFAFMLHLIDQYD LYSKRFAVFLSEVSE++L+QLNLN+EWT +KLRQ+
Sbjct: 360 SSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQR 419
Query: 411 LQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHS 470
L +NA +LEL L ML G+PDTVF+L E+E L+LE I D+T PP ++QL L+EL L H+
Sbjct: 420 LTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHT 479
Query: 471 PARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLES 530
A++ FLR++L+ + +K +++E+PLW++ L+ LEELHL G E R ++
Sbjct: 480 AAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG 539
Query: 531 LRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELV 590
LRELK+LKVL L+SN K+P VTDV HLQ+LS++N+G +L+ LNSLKK+A L ELEL+
Sbjct: 540 LRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELI 599
Query: 591 ACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVR 650
C LERIPH++FSL LQE+DLKDN+L++IEEI+SFQH +L L+LW+N IAY+P +
Sbjct: 600 RCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659
Query: 651 KLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNA 710
L +LE+LYL+ NK+E +P+QL C LR LD+SHN L LP ++GLLQNLQ+LA++ N
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
Query: 711 LEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGL 770
+E LP ELF CRKLR L LG+N L L VG L L+++EL+GNRLE LP ELG C L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779
Query: 771 KKAGLLVEDTLYQGLPAEVRDKM 793
K++GL+VE+ L+ LP EV++++
Sbjct: 780 KRSGLVVEEDLFNTLPPEVKERL 802
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 858 bits (2218), Expect = 0.0
Identities = 430/803 (53%), Positives = 573/803 (71%), Gaps = 11/803 (1%)
Query: 1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPNHEL 60
MIPV E + F + QPA+++LKPWWDV +Y+++ MLMI VFG TLQVTQDK+ICLP +
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60
Query: 61 QENLSEAPCQQLLPRGIPEQIGALQEV--------KGLKNNLDLQQYSFINQLCYETALH 112
++ + G PE + G+K +LD QY++++ +CYE LH
Sbjct: 61 TKDSCNDSFRGWAAPG-PEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLH 119
Query: 113 WYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGE 172
W+AKYFPYLV++HTLIF+ C++FWFKFP TSSK+EHF+SIL KCFDSPWTTRALSE E
Sbjct: 120 WFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVE 179
Query: 173 NQKGPAATERAAATIVAMAGTGPG--KAGEGEKEKVLAEPEKVVTEPPVVTLLDKKEGEQ 230
A + ++ + T +A ++ + E+ + + +LDKKEGEQ
Sbjct: 180 ESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQ 239
Query: 231 AKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVET 290
AKALFEKVKKFR HVEEGDI+Y +Y+RQT++KV KF+ I+ Y + YV I F V C V+
Sbjct: 240 AKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDI 299
Query: 291 SEVTGYASFCCNHTKAHLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREE 350
+TGY ++ C H A LF LA YIS V YGL C+YTL+W+ R LK+YSF S+REE
Sbjct: 300 ESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREE 359
Query: 351 TGMGDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQK 410
+ DIPDVKNDFAFMLHLIDQYD LYSKRFAVFLSEVSE++L+QLNLN+EWT +KLRQ+
Sbjct: 360 SSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQR 419
Query: 411 LQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHS 470
L +NA +LEL L ML G+PDTVF+L E+E L+LE I D+T PP ++QL L+EL L H+
Sbjct: 420 LTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHT 479
Query: 471 PARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLES 530
A++ FLR++L+ + +K +++E+PLW++ L+ LEELHL G E R ++
Sbjct: 480 AAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG 539
Query: 531 LRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELV 590
LRELK+LKVL L+SN K+P VTDV HLQ+LS++N+G +L+ LNSLKK+A L ELEL+
Sbjct: 540 LRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELI 599
Query: 591 ACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVR 650
C LERIPH++FSL LQE+DLKDN+L++IEEI+SFQH +L L+LW+N IAY+P +
Sbjct: 600 RCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659
Query: 651 KLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNA 710
L +LE+LYL+ NK+E +P+QL C LR LD+SHN L LP ++GLLQNLQ+LA++ N
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
Query: 711 LEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGL 770
+E LP ELF CRKLR L LG+N L L VG L L+++EL+GNRLE LP ELG C L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779
Query: 771 KKAGLLVEDTLYQGLPAEVRDKM 793
K++GL+VE+ L+ LP EV++++
Sbjct: 780 KRSGLVVEEDLFNTLPPEVKERL 802
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 858 bits (2218), Expect = 0.0
Identities = 430/803 (53%), Positives = 573/803 (71%), Gaps = 11/803 (1%)
Query: 1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPNHEL 60
MIPV E + F + QPA+++LKPWWDV +Y+++ MLMI VFG TLQVTQDK+ICLP +
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60
Query: 61 QENLSEAPCQQLLPRGIPEQIGALQEV--------KGLKNNLDLQQYSFINQLCYETALH 112
++ + G PE + G+K +LD QY++++ +CYE LH
Sbjct: 61 TKDSCNDSFRGWAAPG-PEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLH 119
Query: 113 WYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGE 172
W+AKYFPYLV++HTLIF+ C++FWFKFP TSSK+EHF+SIL KCFDSPWTTRALSE E
Sbjct: 120 WFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVE 179
Query: 173 NQKGPAATERAAATIVAMAGTGPG--KAGEGEKEKVLAEPEKVVTEPPVVTLLDKKEGEQ 230
A + ++ + T +A ++ + E+ + + +LDKKEGEQ
Sbjct: 180 ESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQ 239
Query: 231 AKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVET 290
AKALFEKVKKFR HVEEGDI+Y +Y+RQT++KV KF+ I+ Y + YV I F V C V+
Sbjct: 240 AKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDI 299
Query: 291 SEVTGYASFCCNHTKAHLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREE 350
+TGY ++ C H A LF LA YIS V YGL C+YTL+W+ R LK+YSF S+REE
Sbjct: 300 ESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREE 359
Query: 351 TGMGDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQK 410
+ DIPDVKNDFAFMLHLIDQYD LYSKRFAVFLSEVSE++L+QLNLN+EWT +KLRQ+
Sbjct: 360 SSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQR 419
Query: 411 LQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHS 470
L +NA +LEL L ML G+PDTVF+L E+E L+LE I D+T PP ++QL L+EL L H+
Sbjct: 420 LTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHT 479
Query: 471 PARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLES 530
A++ FLR++L+ + +K +++E+PLW++ L+ LEELHL G E R ++
Sbjct: 480 AAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG 539
Query: 531 LRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELV 590
LRELK+LKVL L+SN K+P VTDV HLQ+LS++N+G +L+ LNSLKK+A L ELEL+
Sbjct: 540 LRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELI 599
Query: 591 ACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVR 650
C LERIPH++FSL LQE+DLKDN+L++IEEI+SFQH +L L+LW+N IAY+P +
Sbjct: 600 RCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659
Query: 651 KLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNA 710
L +LE+LYL+ NK+E +P+QL C LR LD+SHN L LP ++GLLQNLQ+LA++ N
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
Query: 711 LEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGL 770
+E LP ELF CRKLR L LG+N L L VG L L+++EL+GNRLE LP ELG C L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779
Query: 771 KKAGLLVEDTLYQGLPAEVRDKM 793
K++GL+VE+ L+ LP EV++++
Sbjct: 780 KRSGLVVEEDLFNTLPPEVKERL 802
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 806 bits (2082), Expect = 0.0
Identities = 411/850 (48%), Positives = 559/850 (65%), Gaps = 55/850 (6%)
Query: 1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLP---- 56
M +AE + QP +++LKPWWDV +YL V MLM+ +F T+Q+T+D+++CLP
Sbjct: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
Query: 57 -----------NHELQENLS---------------------------EAPCQQLLPR--- 75
N E+ N+ + P + PR
Sbjct: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
Query: 76 GIPEQIGALQEVK---GLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVC 132
+P Q A +E K G K NLD QQY FINQ+CY AL WY+KYFPYL +IHT+I MV
Sbjct: 121 ALPNQ-EAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVS 179
Query: 133 TSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENQKGPAATERAAATIVAMAG 192
++FWFK+P T SK+EHF+SILGKCF+SPWTT+ALSE + E+ + A T+
Sbjct: 180 SNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVS 239
Query: 193 TGPGKAGEGEKEKVLAEP------EKVVTEPPVVTLLDKKEGEQAKALFEKVKKFRMHVE 246
T + ++ + EK V E P +T+LDKK+GEQAKALFEKV+KFR HVE
Sbjct: 240 TSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVE 299
Query: 247 EGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVETSEVTGYASFCCNHTKA 306
+ D++Y +Y+ QTV+K KF+ IL Y +V ISF C+ + + GY F C H A
Sbjct: 300 DSDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMA 359
Query: 307 HLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREETGMGDIPDVKNDFAFM 366
++ KL YIS +C+YG C+YTL+WLF PLKEYSF VREE+ DIPDVKNDFAF+
Sbjct: 360 YMLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFL 419
Query: 367 LHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNAAGRLELALCML 426
LH++DQYD LYSKRF VFLSEVSE++L++++LNHEWT EKLRQ + RNA + EL L ML
Sbjct: 420 LHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFML 479
Query: 427 PGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHL 486
G+PD VF+L++++ L+LE I + P +SQ+ +LQEL L H PA++ + FLRDHL
Sbjct: 480 SGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHL 539
Query: 487 KVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNA 546
+ + VK ++ E+P WV+ L+ L EL+L G E + LESLREL+ LK+L ++SN
Sbjct: 540 RCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNL 599
Query: 547 GKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGA 606
KVP+++TDVA HL +L +HNDG +L+ LNSLKK+ + ELEL C LERIPHA+FSL
Sbjct: 600 TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSN 659
Query: 607 LQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLE 666
LQELDLK N++R+IEEI+SFQH ++L L+LWHN+I +P + +++LE LY S NKLE
Sbjct: 660 LQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE 719
Query: 667 TLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRT 726
+LP + LR LDVS+N + +P E+GLLQNLQHL ++ N ++ LP++LF C KLRT
Sbjct: 720 SLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRT 779
Query: 727 LLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLP 786
L LG N ++ L VG L L++LELKGN L+ LP +LG C LKK+GL+VED L+ LP
Sbjct: 780 LNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
Query: 787 AEVRDKMEEE 796
EV++ + ++
Sbjct: 840 LEVKEALNQD 849
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 806 bits (2082), Expect = 0.0
Identities = 411/850 (48%), Positives = 559/850 (65%), Gaps = 55/850 (6%)
Query: 1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLP---- 56
M +AE + QP +++LKPWWDV +YL V MLM+ +F T+Q+T+D+++CLP
Sbjct: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
Query: 57 -----------NHELQENLS---------------------------EAPCQQLLPR--- 75
N E+ N+ + P + PR
Sbjct: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
Query: 76 GIPEQIGALQEVK---GLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVC 132
+P Q A +E K G K NLD QQY FINQ+CY AL WY+KYFPYL +IHT+I MV
Sbjct: 121 ALPNQ-EAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVS 179
Query: 133 TSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENQKGPAATERAAATIVAMAG 192
++FWFK+P T SK+EHF+SILGKCF+SPWTT+ALSE + E+ + A T+
Sbjct: 180 SNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVS 239
Query: 193 TGPGKAGEGEKEKVLAEP------EKVVTEPPVVTLLDKKEGEQAKALFEKVKKFRMHVE 246
T + ++ + EK V E P +T+LDKK+GEQAKALFEKV+KFR HVE
Sbjct: 240 TSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVE 299
Query: 247 EGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVETSEVTGYASFCCNHTKA 306
+ D++Y +Y+ QTV+K KF+ IL Y +V ISF C+ + + GY F C H A
Sbjct: 300 DSDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMA 359
Query: 307 HLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREETGMGDIPDVKNDFAFM 366
++ KL YIS +C+YG C+YTL+WLF PLKEYSF VREE+ DIPDVKNDFAF+
Sbjct: 360 YMLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFL 419
Query: 367 LHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNAAGRLELALCML 426
LH++DQYD LYSKRF VFLSEVSE++L++++LNHEWT EKLRQ + RNA + EL L ML
Sbjct: 420 LHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFML 479
Query: 427 PGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHL 486
G+PD VF+L++++ L+LE I + P +SQ+ +LQEL L H PA++ + FLRDHL
Sbjct: 480 SGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHL 539
Query: 487 KVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNA 546
+ + VK ++ E+P WV+ L+ L EL+L G E + LESLREL+ LK+L ++SN
Sbjct: 540 RCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNL 599
Query: 547 GKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGA 606
KVP+++TDVA HL +L +HNDG +L+ LNSLKK+ + ELEL C LERIPHA+FSL
Sbjct: 600 TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSN 659
Query: 607 LQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLE 666
LQELDLK N++R+IEEI+SFQH ++L L+LWHN+I +P + +++LE LY S NKLE
Sbjct: 660 LQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE 719
Query: 667 TLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRT 726
+LP + LR LDVS+N + +P E+GLLQNLQHL ++ N ++ LP++LF C KLRT
Sbjct: 720 SLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRT 779
Query: 727 LLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLP 786
L LG N ++ L VG L L++LELKGN L+ LP +LG C LKK+GL+VED L+ LP
Sbjct: 780 LNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
Query: 787 AEVRDKMEEE 796
EV++ + ++
Sbjct: 840 LEVKEALNQD 849
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 738 bits (1906), Expect = 0.0
Identities = 375/806 (46%), Positives = 530/806 (65%), Gaps = 21/806 (2%)
Query: 1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIIC-LPNHE 59
MI + E K + Q ++ +LKPWWDV Y+T+ ML++ V LQ+TQ +++C LP
Sbjct: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
Query: 60 LQENLSEAPCQQL-----------LPRGIPEQIGALQEVKGLKNNLDLQQYSFINQLCYE 108
+N P L P +P +I +N+L QQYS+I+ +CYE
Sbjct: 61 EFDNHCAVPWDILKASMNTSSNPGTPLPLPLRI---------QNDLHRQQYSYIDAVCYE 111
Query: 109 TALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSE 168
LHW+AK+FPYLV++HTLIF C++FW +P TSS++EHF++IL KCFDSPWTTRALSE
Sbjct: 112 KQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSE 171
Query: 169 VSGENQKGPAATERAAATIVAMAGTGPGKAGEGEKEKVLAEPEKVVTEPPVVTLLDKKEG 228
E P ++ + + + +G+ E E P ++LDKKEG
Sbjct: 172 TVAEQSVRPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEG 231
Query: 229 EQAKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRV 288
EQAKA+FEKVK+FRMHVE+ DI+Y +Y++Q ++KV F+ I+ Y ++ I+ + C V
Sbjct: 232 EQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSV 291
Query: 289 ETSEVTGYASFCCNHTKAHLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVR 348
+ TGY + C ++ A +F LA Y+ V +YGLT Y+L+W+ LK+YSF ++R
Sbjct: 292 DVQAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALR 351
Query: 349 EETGMGDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLR 408
E++ DIPDVKNDFAF+LHL DQYD LYSKRF++FLSEVSE++LKQ+NLN+EWT EKL+
Sbjct: 352 EKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLK 411
Query: 409 QKLQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLL 468
KL +NA ++EL L ML GLPD VFEL+E+E L LE I ++ P +SQLV+L+EL +
Sbjct: 412 SKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVY 471
Query: 469 HSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATL 528
HS + FL ++LK++R+K E+ ++P WVF L+ L+EL+L G E L
Sbjct: 472 HSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQL 531
Query: 529 ESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELE 588
E ++LK L+ L L+S+ ++P VTD+ LQ+LSL N+G++LV LN+LKK+ L+ LE
Sbjct: 532 EGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLE 591
Query: 589 LVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEH 648
L++C LERIPH++FSL L ELDL++N+L+++EEI+SFQH + L L+LWHN IAY+P
Sbjct: 592 LISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQ 651
Query: 649 VRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSY 708
+ L +LEQL L +N +E LP QL LC+ L LD+S+N L +P E+ L NLQ+ A++
Sbjct: 652 IGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTN 711
Query: 709 NALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCG 768
N +E LP+ LF C+KL+ LLLG N L LSPHVG L L+ LEL GN LE LP EL C
Sbjct: 712 NNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQ 771
Query: 769 GLKKAGLLVEDTLYQGLPAEVRDKME 794
LK+ L+VE+ L LP V ++++
Sbjct: 772 SLKRNCLIVEENLLNTLPLPVTERLQ 797
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 738 bits (1906), Expect = 0.0
Identities = 375/806 (46%), Positives = 530/806 (65%), Gaps = 21/806 (2%)
Query: 1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIIC-LPNHE 59
MI + E K + Q ++ +LKPWWDV Y+T+ ML++ V LQ+TQ +++C LP
Sbjct: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
Query: 60 LQENLSEAPCQQL-----------LPRGIPEQIGALQEVKGLKNNLDLQQYSFINQLCYE 108
+N P L P +P +I +N+L QQYS+I+ +CYE
Sbjct: 61 EFDNHCAVPWDILKASMNTSSNPGTPLPLPLRI---------QNDLHRQQYSYIDAVCYE 111
Query: 109 TALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSE 168
LHW+AK+FPYLV++HTLIF C++FW +P TSS++EHF++IL KCFDSPWTTRALSE
Sbjct: 112 KQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSE 171
Query: 169 VSGENQKGPAATERAAATIVAMAGTGPGKAGEGEKEKVLAEPEKVVTEPPVVTLLDKKEG 228
E P ++ + + + +G+ E E P ++LDKKEG
Sbjct: 172 TVAEQSVRPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEG 231
Query: 229 EQAKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRV 288
EQAKA+FEKVK+FRMHVE+ DI+Y +Y++Q ++KV F+ I+ Y ++ I+ + C V
Sbjct: 232 EQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSV 291
Query: 289 ETSEVTGYASFCCNHTKAHLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVR 348
+ TGY + C ++ A +F LA Y+ V +YGLT Y+L+W+ LK+YSF ++R
Sbjct: 292 DVQAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALR 351
Query: 349 EETGMGDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLR 408
E++ DIPDVKNDFAF+LHL DQYD LYSKRF++FLSEVSE++LKQ+NLN+EWT EKL+
Sbjct: 352 EKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLK 411
Query: 409 QKLQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLL 468
KL +NA ++EL L ML GLPD VFEL+E+E L LE I ++ P +SQLV+L+EL +
Sbjct: 412 SKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVY 471
Query: 469 HSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATL 528
HS + FL ++LK++R+K E+ ++P WVF L+ L+EL+L G E L
Sbjct: 472 HSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQL 531
Query: 529 ESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELE 588
E ++LK L+ L L+S+ ++P VTD+ LQ+LSL N+G++LV LN+LKK+ L+ LE
Sbjct: 532 EGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLE 591
Query: 589 LVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEH 648
L++C LERIPH++FSL L ELDL++N+L+++EEI+SFQH + L L+LWHN IAY+P
Sbjct: 592 LISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQ 651
Query: 649 VRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSY 708
+ L +LEQL L +N +E LP QL LC+ L LD+S+N L +P E+ L NLQ+ A++
Sbjct: 652 IGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTN 711
Query: 709 NALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCG 768
N +E LP+ LF C+KL+ LLLG N L LSPHVG L L+ LEL GN LE LP EL C
Sbjct: 712 NNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQ 771
Query: 769 GLKKAGLLVEDTLYQGLPAEVRDKME 794
LK+ L+VE+ L LP V ++++
Sbjct: 772 SLKRNCLIVEENLLNTLPLPVTERLQ 797
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 120 bits (302), Expect = 4e-27
Identities = 98/353 (27%), Positives = 165/353 (46%), Gaps = 28/353 (7%)
Query: 429 LPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKV 488
LP +F + L L T P ++ L++L+EL + + + F + L +
Sbjct: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EFPENIKNCKVLTI 119
Query: 489 MRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNAGK 548
+ + ++P L L +L+L F + L + L +L++L LR N K
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPA-----NFGRLTKLQILELRENQLK 174
Query: 549 VPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQ 608
+ + L+RL L ++ V L++L+ L+E + A L IP + SL L
Sbjct: 175 MLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLT 233
Query: 609 ELDLKDNHLRSIEEILS---------------------FQHCRKLVTLRLWHNQIAYVPE 647
LD+ N++ +EE +S + + TL++ NQ+ Y+P+
Sbjct: 234 YLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPD 293
Query: 648 HVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALS 707
+ L S+E+L S+N++E LPS +G + LR HN L LPPE+G +N+ L L
Sbjct: 294 SIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLH 353
Query: 708 YNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEAL 760
N LE LPEE+ +KL+ + L DN+L L L+ L+ + L N+ + L
Sbjct: 354 SNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
Score = 70.1 bits (170), Expect = 8e-12
Identities = 51/155 (32%), Positives = 76/155 (49%), Gaps = 2/155 (1%)
Query: 621 EEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRL 680
+EI +F+ + L L L NQI +P+ + +SL +L L N L TLP+ + LR
Sbjct: 39 KEIFTFE--KTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRE 96
Query: 681 LDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPH 740
LDVS NG+ P + + L + S N + LP+ L L L D L L +
Sbjct: 97 LDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN 156
Query: 741 VGALRALSRLELKGNRLEALPEELGNCGGLKKAGL 775
G L L LEL+ N+L+ LP+ + L++ L
Sbjct: 157 FGRLTKLQILELRENQLKMLPKTMNRLTQLERLDL 191
Score = 53.1 bits (126), Expect = 1e-06
Identities = 71/298 (23%), Positives = 119/298 (39%), Gaps = 59/298 (19%)
Query: 419 LELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSL 478
LEL L LP T+ L+++E L L + P L QL L+E + RL F
Sbjct: 166 LELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWM--DANRLTF-- 221
Query: 479 QVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLK 538
+P ++ L KQL
Sbjct: 222 --------------------IPGFIGSL----------------------------KQLT 233
Query: 539 VLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLV--ALNSLKKLAALRELELVACGLER 596
L + N ++ +LQ L L ++ + + + SLK + L+ + L
Sbjct: 234 YLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK---IDENQLMY 290
Query: 597 IPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLE 656
+P ++ L +++ELD N + ++ S L T HN + +P + +++
Sbjct: 291 LPDSIGGLISVEELDCSFNEVEALPS--SIGQLTNLRTFAADHNYLQQLPPEIGSWKNIT 348
Query: 657 QLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEAL 714
L+L NKLETLP ++G L+++++S N L +LP LQ L + LS N + L
Sbjct: 349 VLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 120 bits (302), Expect = 4e-27
Identities = 98/353 (27%), Positives = 165/353 (46%), Gaps = 28/353 (7%)
Query: 429 LPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKV 488
LP +F + L L T P ++ L++L+EL + + + F + L +
Sbjct: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EFPENIKNCKVLTI 119
Query: 489 MRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNAGK 548
+ + ++P L L +L+L F + L + L +L++L LR N K
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPA-----NFGRLTKLQILELRENQLK 174
Query: 549 VPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQ 608
+ + L+RL L ++ V L++L+ L+E + A L IP + SL L
Sbjct: 175 MLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLT 233
Query: 609 ELDLKDNHLRSIEEILS---------------------FQHCRKLVTLRLWHNQIAYVPE 647
LD+ N++ +EE +S + + TL++ NQ+ Y+P+
Sbjct: 234 YLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPD 293
Query: 648 HVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALS 707
+ L S+E+L S+N++E LPS +G + LR HN L LPPE+G +N+ L L
Sbjct: 294 SIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLH 353
Query: 708 YNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEAL 760
N LE LPEE+ +KL+ + L DN+L L L+ L+ + L N+ + L
Sbjct: 354 SNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
Score = 70.1 bits (170), Expect = 8e-12
Identities = 51/155 (32%), Positives = 76/155 (49%), Gaps = 2/155 (1%)
Query: 621 EEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRL 680
+EI +F+ + L L L NQI +P+ + +SL +L L N L TLP+ + LR
Sbjct: 39 KEIFTFE--KTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRE 96
Query: 681 LDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPH 740
LDVS NG+ P + + L + S N + LP+ L L L D L L +
Sbjct: 97 LDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN 156
Query: 741 VGALRALSRLELKGNRLEALPEELGNCGGLKKAGL 775
G L L LEL+ N+L+ LP+ + L++ L
Sbjct: 157 FGRLTKLQILELRENQLKMLPKTMNRLTQLERLDL 191
Score = 53.1 bits (126), Expect = 1e-06
Identities = 71/298 (23%), Positives = 119/298 (39%), Gaps = 59/298 (19%)
Query: 419 LELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSL 478
LEL L LP T+ L+++E L L + P L QL L+E + RL F
Sbjct: 166 LELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWM--DANRLTF-- 221
Query: 479 QVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLK 538
+P ++ L KQL
Sbjct: 222 --------------------IPGFIGSL----------------------------KQLT 233
Query: 539 VLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLV--ALNSLKKLAALRELELVACGLER 596
L + N ++ +LQ L L ++ + + + SLK + L+ + L
Sbjct: 234 YLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK---IDENQLMY 290
Query: 597 IPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLE 656
+P ++ L +++ELD N + ++ S L T HN + +P + +++
Sbjct: 291 LPDSIGGLISVEELDCSFNEVEALPS--SIGQLTNLRTFAADHNYLQQLPPEIGSWKNIT 348
Query: 657 QLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEAL 714
L+L NKLETLP ++G L+++++S N L +LP LQ L + LS N + L
Sbjct: 349 VLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 120 bits (300), Expect = 6e-27
Identities = 114/405 (28%), Positives = 181/405 (44%), Gaps = 21/405 (5%)
Query: 392 RLKQLNLNHEWTPEKLRQKLQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDIT 451
+L+ L+L H E + ++ L L + + + LS++ L +
Sbjct: 170 KLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQ 229
Query: 452 FPPGLSQLVHLQELSLLHSPAR-LPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLE 510
P + +L +L L + H+ LP ++ + + ++ EL ++P + L L
Sbjct: 230 LPAEIGELCNLITLDVAHNQLEHLP--KEIGNCTQITNLDLQHNELLDLPDTIGNLSSLS 287
Query: 511 ELHLE----GLFPQELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLH 566
L L P+ LA+ + LE L +N +P S+ L L+L
Sbjct: 288 RLGLRYNRLSAIPRSLAKCSALEELN--------LENNNISTLPESLLSSLVKLNSLTLA 339
Query: 567 NDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLG-ALQELDLKDNHLRSIEEILS 625
+ +L + + + + L + + +IP +FS L +L++KDN L S+ L
Sbjct: 340 RNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLP--LD 397
Query: 626 FQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSH 685
F +V L L NQ+ +PE V L SLE L LS N L+ LP LG LR LD+
Sbjct: 398 FGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEE 457
Query: 686 NGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALR 745
N L SLP E+ L++LQ L L+ N L LP + L L LG+N L+ L +G L
Sbjct: 458 NKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLE 517
Query: 746 ALSRLELKGN-RLEALPEELGNCGGLKKAGLLVEDTLYQGLPAEV 789
L L L N L +LP EL C K + + +E+ LP ++
Sbjct: 518 NLEELYLNDNPNLHSLPFELALCS--KLSIMSIENCPLSHLPPQI 560
Score = 119 bits (298), Expect = 1e-26
Identities = 74/200 (37%), Positives = 112/200 (56%), Gaps = 2/200 (1%)
Query: 576 NSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTL 635
+S+K+L L EL L + L+ +P V L L L L +N L S+ + S + +KL L
Sbjct: 117 SSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD--SLDNLKKLRML 174
Query: 636 RLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEV 695
L HN++ +P V +L SL LYL +N++ T+ + S L +L + N + LP E+
Sbjct: 175 DLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEI 234
Query: 696 GLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGN 755
G L NL L +++N LE LP+E+ C ++ L L N+L L +G L +LSRL L+ N
Sbjct: 235 GELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYN 294
Query: 756 RLEALPEELGNCGGLKKAGL 775
RL A+P L C L++ L
Sbjct: 295 RLSAIPRSLAKCSALEELNL 314
Score = 111 bits (277), Expect = 3e-24
Identities = 115/428 (26%), Positives = 201/428 (46%), Gaps = 58/428 (13%)
Query: 410 KLQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLL- 468
K + + RL+L+ + LP ++ EL+++ L L + + P + LV+L L+L
Sbjct: 96 KCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSE 155
Query: 469 HSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATL 528
+S LP SL + L+++ ++ +LRE+P V+ L L L+L R T+
Sbjct: 156 NSLTSLPDSLDNLKK--LRMLDLRHNKLREIPSVVYRLDSLTTLYL------RFNRITTV 207
Query: 529 E-SLRELKQLKVLSLRSNAGK-VPASVTDVAGHLQRLSLHND------------------ 568
E ++ L +L +LS+R N K +PA + ++ + HN
Sbjct: 208 EKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLD 267
Query: 569 ---GARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEIL- 624
L +++ L++L L L L IP ++ AL+EL+L++N++ ++ E L
Sbjct: 268 LQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLL 327
Query: 625 ----------SFQHCRKL------------VTLRLWHNQIAYVPEHV-RKLRSLEQLYLS 661
++C +L +L + HN+I +P + + + L +L +
Sbjct: 328 SSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMK 387
Query: 662 YNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFC 721
N+L +LP G + + L+++ N L +P +V L +L+ L LS N L+ LP L
Sbjct: 388 DNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNL 447
Query: 722 RKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTL 781
RKLR L L +N+L L + L+ L +L L N+L LP +G+ L GL + L
Sbjct: 448 RKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGL--GENL 505
Query: 782 YQGLPAEV 789
LP E+
Sbjct: 506 LTHLPEEI 513
Score = 90.1 bits (222), Expect = 7e-18
Identities = 93/335 (27%), Positives = 152/335 (45%), Gaps = 25/335 (7%)
Query: 419 LELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSP-ARLPFS 477
L++A L LP + +++ +L L+ + P + L L L L ++ + +P S
Sbjct: 243 LDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRS 302
Query: 478 LQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFP-QELARAATLESL----- 531
L KC L E+ L + L E L L L A L
Sbjct: 303 L------------AKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGG 350
Query: 532 -RELKQLKVLSLRSNA-GKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELEL 589
+ + L++ N K+P + A L +L++ ++ + L+ ++ EL L
Sbjct: 351 PSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLD-FGTWTSMVELNL 409
Query: 590 VACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHV 649
L +IP V L +L+ L L +N L+ + L + RKL L L N++ +P +
Sbjct: 410 ATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLG--NLRKLRELDLEENKLESLPNEI 467
Query: 650 RKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYN 709
L+ L++L L+ N+L TLP +G + L L + N L LP E+G L+NL+ L L+ N
Sbjct: 468 AYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDN 527
Query: 710 A-LEALPEELFFCRKLRTLLLGDNQLSQLSPHVGA 743
L +LP EL C KL + + + LS L P + A
Sbjct: 528 PNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 562
Score = 80.9 bits (198), Expect = 4e-15
Identities = 54/171 (31%), Positives = 88/171 (51%), Gaps = 4/171 (2%)
Query: 621 EEILSFQHCRKLVTLRL--WHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGL 678
E I CR+ ++RL I +P +++L L +LYL NKL++LP+++G L
Sbjct: 89 EVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNL 148
Query: 679 RLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLS 738
L +S N L SLP + L+ L+ L L +N L +P ++ L TL L N+++ +
Sbjct: 149 MTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVE 208
Query: 739 PHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLPAEV 789
+ L LS L ++ N+++ LP E+G L L V + LP E+
Sbjct: 209 KDIKNLSKLSMLSIRENKIKQLPAEIGELCNL--ITLDVAHNQLEHLPKEI 257
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 114 bits (286), Expect = 3e-25
Identities = 107/371 (28%), Positives = 160/371 (43%), Gaps = 56/371 (15%)
Query: 466 SLLHSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARA 525
S+ HSP + + D + + L +PL +F LEE+HLE +E+
Sbjct: 7 SVEHSPKIHQRNDPQHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIP-- 64
Query: 526 ATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALR 585
+ ++ LK ++VL L N + + L+ L L + +L + L ALR
Sbjct: 65 ---QEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALR 121
Query: 586 ELELVACGLERIPHAVF-SLGALQELDLKDNHLRSI-EEILSFQHCRKLVTLR------- 636
EL L L+ IP +F +L L+ L L NHL+ + +EI++ R++ R
Sbjct: 122 ELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFP 181
Query: 637 -------------LWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDV 683
L N+I +PE + L L++ Y++ N L LP+ L CS L +LD+
Sbjct: 182 QELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDL 241
Query: 684 SHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCR--------------------- 722
SHN LHS+P L+ + + LS N LE +P CR
Sbjct: 242 SHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPR--LICRWTSLHLLYLGNTGLHRLRGSF 299
Query: 723 ----KLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVE 778
LR L L N L + AL+ L L L N++ LP ELG+ LK GL
Sbjct: 300 RCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGN 359
Query: 779 DTLYQGLPAEV 789
+ L P EV
Sbjct: 360 EFL--SFPEEV 368
Score = 100 bits (250), Expect = 4e-21
Identities = 98/364 (26%), Positives = 163/364 (44%), Gaps = 12/364 (3%)
Query: 429 LPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKV 488
+P + L + L L+ + P L L L+ L L ++P + V L+
Sbjct: 63 IPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRE 122
Query: 489 MRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNAGK 548
+R+ +L+E+P+ +F + L L L GL L + E + + K L+ + L+ N +
Sbjct: 123 LRLYQTDLKEIPVVIF--KNLHHLELLGLTGNHL-KCLPKEIVNQTK-LREIYLKRNQFE 178
Query: 549 VPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQ 608
V V L+ + L + + + L L++ + + L +P ++ L
Sbjct: 179 VFPQELCVLYTLEIIDLDENKIGAIP-EEIGHLTGLQKFYMASNNLPVLPASLCQCSQLS 237
Query: 609 ELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETL 668
LDL N L SI + SF RK+ + L N++ VP + + SL LYL L L
Sbjct: 238 VLDLSHNLLHSIPK--SFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRL 295
Query: 669 PSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLL 728
LR LD+S N LH P ++ L+NL+ L L N + LP EL KL+ L
Sbjct: 296 RGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILG 355
Query: 729 LGDNQLSQLSPHVGALRALSRLEL---KGNRLEALPEELGNCGGLKKAGLLVEDTLYQGL 785
L N+ V +L +L +L + +G +L +PE + LK+ L +E+ + L
Sbjct: 356 LTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKE--LYIENNHLEYL 413
Query: 786 PAEV 789
P +
Sbjct: 414 PVSL 417
Score = 92.8 bits (229), Expect = 1e-18
Identities = 100/334 (29%), Positives = 148/334 (44%), Gaps = 21/334 (6%)
Query: 406 KLRQ-KLQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQE 464
KLR+ L+RN LC+L L E+ +++ ++ AI P + L LQ+
Sbjct: 166 KLREIYLKRNQFEVFPQELCVLYTL-----EIIDLDENKIGAI-----PEEIGHLTGLQK 215
Query: 465 LSLLHSPAR-LPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELA 523
+ + LP SL L V+ + L +P LR + E+ L G +++
Sbjct: 216 FYMASNNLPVLPASLCQC--SQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVP 273
Query: 524 RAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAA 583
R + L L L G V L + LH+ ++ AL +L+ L
Sbjct: 274 RLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLG- 332
Query: 584 LRELELVACGLERIPHAVFSLGALQELDLKDNHLRSI-EEILSFQHCRKLVTLRLWHNQI 642
L + ++P + SL L+ L L N S EE+LS KL + ++
Sbjct: 333 -----LDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKL 387
Query: 643 AYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQ 702
YVPEH+RKL+SL++LY+ N LE LP LG L +LD HN L LP + Q L+
Sbjct: 388 TYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALK 447
Query: 703 HLALSYNALEALPEELFFCRKLRTLLLGDNQLSQ 736
L L N L LPE L L+ L L DN + +
Sbjct: 448 ELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEE 481
Score = 84.3 bits (207), Expect = 4e-16
Identities = 97/374 (25%), Positives = 164/374 (43%), Gaps = 28/374 (7%)
Query: 414 NAAGRLELALCMLPGLPDTVFE-LSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPA 472
+A L L L +P +F+ L +E L L P + L+E+ L +
Sbjct: 118 HALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQF 177
Query: 473 RLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEG----LFPQELARAATL 528
+ F ++ + L+++ + ++ +P + L GL++ ++ + P L + + L
Sbjct: 178 EV-FPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQL 236
Query: 529 --------------ESLRELKQLKVLSLRSNA-GKVPASVTDVAGHLQRLSLHNDGARLV 573
+S EL+++ + L N KVP + L L L N G +
Sbjct: 237 SVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTS-LHLLYLGNTGLHRL 295
Query: 574 ALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLV 633
S + L LR L+L L P + +L L+ L L DN + + L KL
Sbjct: 296 R-GSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELG--SLSKLK 352
Query: 634 TLRLWHNQIAYVPEHVRKLRSLEQLYLSYN---KLETLPSQLGLCSGLRLLDVSHNGLHS 690
L L N+ PE V L SLE+LY+ + KL +P + L+ L + +N L
Sbjct: 353 ILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEY 412
Query: 691 LPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRL 750
LP +G + NL+ L +N L+ LP+ + + L+ L L DN L+ L ++ +L L L
Sbjct: 413 LPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVL 472
Query: 751 ELKGNRLEALPEEL 764
L N +E P+E+
Sbjct: 473 TLMDNPMEEPPKEV 486
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 114 bits (284), Expect = 5e-25
Identities = 100/351 (28%), Positives = 166/351 (47%), Gaps = 24/351 (6%)
Query: 429 LPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKV 488
LP +F + L + P ++ LV+L+EL + + + F + L +
Sbjct: 61 LPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQ-EFPENIKCCKCLTI 119
Query: 489 MRVKCEELREVPLWVFGLRGLEELHLEGLF----PQELARAATL--------------ES 530
+ + ++P L L +L+L F P R L +S
Sbjct: 120 IEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS 179
Query: 531 LRELKQLKVLSLRSNA-GKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELEL 589
+ +L QL+ L L +N G++P V D +L+ L + N+ +++ S+ KL L L++
Sbjct: 180 MHKLAQLERLDLGNNEFGELP-EVLDQIQNLRELWMDNNALQVLP-GSIGKLKMLVYLDM 237
Query: 590 VACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHV 649
+E + + AL++L L N L+ + + + +KL TL++ NQ+ +P +
Sbjct: 238 SKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGL--LKKLTTLKVDDNQLTMLPNTI 295
Query: 650 RKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYN 709
L LE+ S N+LE+LPS +G LR L V N L LP E+G +N+ ++L N
Sbjct: 296 GNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSN 355
Query: 710 ALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEAL 760
LE LPEE+ +KLR L L DN+L L L+ L+ L L N+ +AL
Sbjct: 356 KLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
Score = 109 bits (272), Expect = 1e-23
Identities = 94/330 (28%), Positives = 150/330 (45%), Gaps = 31/330 (9%)
Query: 479 QVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLK 538
Q+F L+ + + +L +P + L L+EL + QE E+++ K L
Sbjct: 64 QLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFP-----ENIKCCKCLT 118
Query: 539 VLSLRSNA-GKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERI 597
++ N K+P T + +L +L L++ + N +L LR LEL L+ +
Sbjct: 119 IIEASVNPISKLPDGFTQLL-NLTQLYLNDAFLEFLPAN-FGRLVKLRILELRENHLKTL 176
Query: 598 PHAVFSLGALQELDLKDNHLRSIEEIL---------------------SFQHCRKLVTLR 636
P ++ L L+ LDL +N + E+L S + LV L
Sbjct: 177 PKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLD 236
Query: 637 LWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVG 696
+ N+I V + +LE L LS N L+ LP +GL L L V N L LP +G
Sbjct: 237 MSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 296
Query: 697 LLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNR 756
L L+ S N LE+LP + + LRTL + +N L +L +G+ + ++ + L+ N+
Sbjct: 297 NLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNK 356
Query: 757 LEALPEELGNCGGLKKAGLLVEDTLYQGLP 786
LE LPEE+G L+ L D + LP
Sbjct: 357 LEFLPEEIGQMQKLRVLNL--SDNRLKNLP 384
Score = 74.7 bits (182), Expect = 3e-13
Identities = 49/147 (33%), Positives = 71/147 (48%), Gaps = 12/147 (8%)
Query: 620 IEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKL-RSLEQLYLSYNKLETLPSQLGLCSGL 678
I +L + HC + VP+ V R+LE+LYL N++E LP QL C L
Sbjct: 23 IISVLDYSHC-----------SLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQAL 71
Query: 679 RLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLS 738
R L + N L +LP + L NL+ L +S N ++ PE + C+ L + N +S+L
Sbjct: 72 RKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLP 131
Query: 739 PHVGALRALSRLELKGNRLEALPEELG 765
L L++L L LE LP G
Sbjct: 132 DGFTQLLNLTQLYLNDAFLEFLPANFG 158
Score = 66.2 bits (160), Expect = 1e-10
Identities = 54/188 (28%), Positives = 86/188 (45%), Gaps = 8/188 (4%)
Query: 589 LVACGLERIPHAVFSLGALQELDLKDNHLRSI-EEILSFQHCRKLVTLRLWHNQIAYVPE 647
LV C R + S+ LD L+ + +E+ +F+ R L L L NQI +P+
Sbjct: 11 LVPCRCFRGEEEIISV-----LDYSHCSLQQVPKEVFNFE--RTLEELYLDANQIEELPK 63
Query: 648 HVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALS 707
+ ++L +L + N L LP+ + L+ LD+S NG+ P + + L + S
Sbjct: 64 QLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEAS 123
Query: 708 YNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNC 767
N + LP+ L L L D L L + G L L LEL+ N L+ LP+ +
Sbjct: 124 VNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKL 183
Query: 768 GGLKKAGL 775
L++ L
Sbjct: 184 AQLERLDL 191
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 109 bits (273), Expect = 9e-24
Identities = 105/359 (29%), Positives = 162/359 (45%), Gaps = 37/359 (10%)
Query: 461 HLQELSLLH-SPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFP 519
H++ + H S +P + + R L+ + + +LRE+P F L L +L GL
Sbjct: 13 HVESIDKRHCSLVYVPEEIYRYARS-LEELLLDANQLRELPEQFFQLVKLRKL---GLSD 68
Query: 520 QELARAAT-LESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSL 578
E+ R + + +L +L V R+ ++P S++ N RL S
Sbjct: 69 NEIQRLPPEIANFMQLVELDVS--RNEIPEIPESISFCKALQVADFSGNPLTRLP--ESF 124
Query: 579 KKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLW 638
+L L L + L+ +P + +L L L+L++N L + + L+ R+L L L
Sbjct: 125 PELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLT--QLRRLEELDLG 182
Query: 639 HNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLL 698
+N+I +PE + L L+ L+L N+L LP ++G L LDVS N L LP E+ L
Sbjct: 183 NNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGL 242
Query: 699 QNLQHLALSYNALEA-----------------------LPEELFFCRKLRTLLLGDNQLS 735
+L L +S N LE LPE + C L L+L +NQL
Sbjct: 243 TSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLL 302
Query: 736 QLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLPAEVRDKME 794
L +G L+ LS L N+L +LP+E+G C L V D +PAEV E
Sbjct: 303 TLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSL--TVFCVRDNRLTRIPAEVSQATE 359
Score = 103 bits (256), Expect = 8e-22
Identities = 106/383 (27%), Positives = 174/383 (45%), Gaps = 30/383 (7%)
Query: 424 CMLPGLPDTVFELSE-VESLRLEAICDITFPPGLSQLVHLQELSLLHSPA-RLPFSLQVF 481
C L +P+ ++ + +E L L+A P QLV L++L L + RLP + F
Sbjct: 22 CSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANF 81
Query: 482 LRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEG--------LFPQ----------ELA 523
++ L + V E+ E+P + + L+ G FP+ +++
Sbjct: 82 MQ--LVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDIS 139
Query: 524 RAATLESLRELKQLKVLSLRSNA-GKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLA 582
+ E++ L L L LR N +P S+T + L+ L L N+ + S+ L
Sbjct: 140 LQSLPENIGNLYNLASLELRENLLTYLPDSLTQLR-RLEELDLGNNEIYNLP-ESIGALL 197
Query: 583 ALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQI 642
L++L L L +P + +L L LD+ +N L + E +S L L + N +
Sbjct: 198 HLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEIS--GLTSLTDLVISQNLL 255
Query: 643 AYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQ 702
+P+ + KL+ L L + N+L LP +G C L L ++ N L +LP +G L+ L
Sbjct: 256 ETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLS 315
Query: 703 HLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPE 762
+L N L +LP+E+ C L + DN+L+++ V L L++ GNRL LP
Sbjct: 316 NLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPL 375
Query: 763 ELGNCGGLKKAGLLVEDTLYQGL 785
L LK L + D Q L
Sbjct: 376 SL---TALKLKALWLSDNQSQPL 395
Score = 57.4 bits (137), Expect = 5e-08
Identities = 82/324 (25%), Positives = 125/324 (38%), Gaps = 89/324 (27%)
Query: 419 LELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSL 478
LEL +L LPD++ +L +E L L P + L+HL++L L
Sbjct: 156 LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWL----------- 204
Query: 479 QVFLRDHLKVMRVKCEELREVPLWVFGLRGL-----EELHLEGLFPQELARAATLESLRE 533
+L E+P + L+ L E LE L P+E++ +L L
Sbjct: 205 -------------DGNQLSELPQEIGNLKNLLCLDVSENRLERL-PEEISGLTSLTDL-- 248
Query: 534 LKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACG 593
V+S + ++ D G L++LS+ L++
Sbjct: 249 -----VIS-----QNLLETIPDGIGKLKKLSI---------------------LKVDQNR 277
Query: 594 LERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLR 653
L ++P AV +L EL L +N L ++ P+ + KL+
Sbjct: 278 LTQLPEAVGECESLTELVLTENQLLTL-------------------------PKSIGKLK 312
Query: 654 SLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEA 713
L L NKL +LP ++G C L + V N L +P EV L L ++ N L
Sbjct: 313 KLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLH 372
Query: 714 LPEELFFCRKLRTLLLGDNQLSQL 737
LP L KL+ L L DNQ L
Sbjct: 373 LPLSL-TALKLKALWLSDNQSQPL 395
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 107 bits (267), Expect = 4e-23
Identities = 94/282 (33%), Positives = 133/282 (47%), Gaps = 21/282 (7%)
Query: 522 LARAATLESLRELKQLKVLSLRSNAGKVPASVTDVA--------------GHLQRLSLHN 567
L R A L + + L+ L+L + AG P + D G ++ L+L N
Sbjct: 14 LWRDAALRARKLRSNLRQLTLTA-AGACPGAGADALESPASPQLVLPANLGDIEALNLGN 72
Query: 568 DGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGA-LQELDLKDNHLRSI-EEILS 625
+G V L +LR L L R+P AV LG L ELD+ N L ++ E++S
Sbjct: 73 NGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVS 132
Query: 626 FQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSH 685
R+L L L HNQ+ +P + L LE+L +S+N+L LP L S LR LDV H
Sbjct: 133 A--LRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDH 190
Query: 686 NGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALR 745
N L + P ++ L L+ L +S N L LPE++ R L+ L L +L L L
Sbjct: 191 NQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELA 250
Query: 746 ALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLPA 787
+L L L N L+ALP + LK L L++ PA
Sbjct: 251 SLESLMLDNNGLQALPAQFSCLQRLKMLNL--SSNLFEEFPA 290
Score = 100 bits (248), Expect = 7e-21
Identities = 86/292 (29%), Positives = 132/292 (45%), Gaps = 40/292 (13%)
Query: 505 GLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNA-GKVPASVTDVAGHLQRL 563
G GLEE+ P+ L A L L+VL LR N ++P +V ++ HL L
Sbjct: 71 GNNGLEEV------PEGLGSA--------LGSLRVLVLRRNRFARLPPAVAELGHHLTEL 116
Query: 564 SLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEI 623
+ ++ + + L LR+L L L +P + +L L+ELD+ N L + +
Sbjct: 117 DVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDS 176
Query: 624 LSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDV 683
LS +L TL + HNQ+ P + +L +LE+L +S N+L LP + L++L +
Sbjct: 177 LSC--LSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWL 234
Query: 684 S-----------------------HNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFF 720
S +NGL +LP + LQ L+ L LS N E P L
Sbjct: 235 SGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLP 294
Query: 721 CRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKK 772
L L L NQL+ + + L L L L NR+ LP+ + GL++
Sbjct: 295 LAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEE 346
Score = 97.4 bits (241), Expect = 4e-20
Identities = 82/252 (32%), Positives = 128/252 (50%), Gaps = 11/252 (4%)
Query: 525 AATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVAL-NSLKKLAA 583
A + +LREL++L + + A +PA + +A HL+ L + + RL L +SL L+
Sbjct: 128 AEVVSALRELRKLNLSHNQLPA--LPAQLGALA-HLEELDVSFN--RLAHLPDSLSCLSR 182
Query: 584 LRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIA 643
LR L++ L P + L AL+ELD+ N LR + E +S R L L L ++
Sbjct: 183 LRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISA--LRALKILWLSGAELG 240
Query: 644 YVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQH 703
+P +L SLE L L N L+ LP+Q L++L++S N P + L L+
Sbjct: 241 TLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEE 300
Query: 704 LALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEE 763
L LS N L ++P + +L TL L +N++ L + L L L L+GN++ LP+
Sbjct: 301 LYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDH 360
Query: 764 LGNCGGLKKAGL 775
G L + GL
Sbjct: 361 FGQ---LSRVGL 369
Score = 79.3 bits (194), Expect = 1e-14
Identities = 107/397 (26%), Positives = 165/397 (41%), Gaps = 72/397 (18%)
Query: 368 HLIDQYDSLYSKRFAVFLSEVSESR-LKQLNLNHEWTPEKLRQKLQRNAAGRLELALCML 426
H + + D +++ A+ VS R L++LNL+H P Q L+++ L
Sbjct: 111 HHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRL 170
Query: 427 PGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHL 486
LPD++ LS + +L ++ FP L QLV L+EL
Sbjct: 171 AHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELD-------------------- 210
Query: 487 KVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLES-LRELKQLKVLSLRSN 545
V LR +P + LR L+ L L G A TL + EL L+ L L +N
Sbjct: 211 ----VSSNRLRGLPEDISALRALKILWLSG------AELGTLPAGFCELASLESLMLDNN 260
Query: 546 A-GKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSL 604
+PA + LQRL + N + L E P A+ L
Sbjct: 261 GLQALPAQFS----CLQRLKMLNLSSNL---------------------FEEFPAALLPL 295
Query: 605 GALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNK 664
L+EL L N L S+ ++S +L+TL L +N+I Y+P+ + +L LE+L L N+
Sbjct: 296 AGLEELYLSRNQLTSVPSLIS--GLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQ 353
Query: 665 LETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKL 724
+ LP G S + L + N L P EV ++ + ++A E + +L
Sbjct: 354 IAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV-CMKGIPYIAAYQK--ELAHSQPAVQPRL 410
Query: 725 RTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALP 761
+ LL+G H A + L R L R+E P
Sbjct: 411 KLLLMG---------HKAAGKTLLRHCLTEERVEGCP 438
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 106 bits (265), Expect = 7e-23
Identities = 106/345 (30%), Positives = 161/345 (46%), Gaps = 12/345 (3%)
Query: 424 CMLPGLPDTVFELSE-VESLRLEAICDITFPPGLSQLVHLQELSLLHSPA-RLPFSLQVF 481
C L +P+ ++ S +E L L+A P +L++L++L L + RLP + F
Sbjct: 22 CSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANF 81
Query: 482 LRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLS 541
++ L + V ++ E+P + + LE G L T LR L L +
Sbjct: 82 MQ--LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFT--QLRSLAHLALND 137
Query: 542 LRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAV 601
+ A +P V ++A +L L L + + + SL L L +L+L LE +P +
Sbjct: 138 VSLQA--LPGDVGNLA-NLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTL 193
Query: 602 FSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLS 661
+L L+EL L N L ++ L + R+LV L + N++ +P + L L L LS
Sbjct: 194 GALPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLS 251
Query: 662 YNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFC 721
N L LP +G L +L V N L + +G +NL L L+ N L ALP L
Sbjct: 252 QNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKL 311
Query: 722 RKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGN 766
KL L + N L L P +G ALS L L+ NRL LP EL +
Sbjct: 312 TKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAH 356
Score = 106 bits (265), Expect = 7e-23
Identities = 100/313 (31%), Positives = 151/313 (48%), Gaps = 28/313 (8%)
Query: 486 LKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAAT-LESLRELKQLKVLSLRS 544
L+ + + +LRE+P F L L +L GL E+ R + + +L +L V R+
Sbjct: 38 LEELLLDANQLRELPKPFFRLLNLRKL---GLSDNEIQRLPPEVANFMQLVELDVS--RN 92
Query: 545 NAGKVPASV--------TDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLER 596
+ ++P S+ D +G+ LS DG +L +L L L L+
Sbjct: 93 DIPEIPESIKFCKALEIADFSGN--PLSRLPDG--------FTQLRSLAHLALNDVSLQA 142
Query: 597 IPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLE 656
+P V +L L L+L++N L+S+ LSF KL L L N + +P+ + L +L
Sbjct: 143 LPGDVGNLANLVTLELRENLLKSLPASLSF--LVKLEQLDLGGNDLEVLPDTLGALPNLR 200
Query: 657 QLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPE 716
+L+L N+L LP +LG L LDVS N L LP E+G L L L LS N L LP+
Sbjct: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260
Query: 717 ELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLL 776
+ ++L L + N+L +++ +G LS L L N L ALP LG K L
Sbjct: 261 GIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKL--TKLTNLN 318
Query: 777 VEDTLYQGLPAEV 789
V+ + LP E+
Sbjct: 319 VDRNHLEALPPEI 331
Score = 105 bits (262), Expect = 2e-22
Identities = 96/283 (33%), Positives = 135/283 (47%), Gaps = 16/283 (5%)
Query: 507 RGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSL- 565
R LEEL L+ +EL + L L+ L L N ++ +VA +Q + L
Sbjct: 36 RSLEELLLDANQLRELPKP-----FFRLLNLRKLGLSDN--EIQRLPPEVANFMQLVELD 88
Query: 566 --HNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEI 623
ND + S+K AL + L R+P L +L L L D L+++
Sbjct: 89 VSRNDIPEIP--ESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGD 146
Query: 624 LSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDV 683
+ + LVTL L N + +P + L LEQL L N LE LP LG LR L +
Sbjct: 147 VG--NLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWL 204
Query: 684 SHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGA 743
N L +LPPE+G L+ L L +S N LE LP EL L LLL N L +L +G
Sbjct: 205 DRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ 264
Query: 744 LRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLP 786
L+ LS L++ NRL + E +G+C L + L++ + L LP
Sbjct: 265 LKQLSILKVDQNRLCEVTEAIGDCENLSE--LILTENLLMALP 305
Score = 82.4 bits (202), Expect = 1e-15
Identities = 55/152 (36%), Positives = 76/152 (50%), Gaps = 3/152 (1%)
Query: 639 HNQIAYVPEHV-RKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGL 697
H + VPE + R RSLE+L L N+L LP LR L +S N + LPPEV
Sbjct: 21 HCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVAN 80
Query: 698 LQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRL 757
L L +S N + +PE + FC+ L N LS+L LR+L+ L L L
Sbjct: 81 FMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSL 140
Query: 758 EALPEELGNCGGLKKAGLLVEDTLYQGLPAEV 789
+ALP ++GN L L + + L + LPA +
Sbjct: 141 QALPGDVGNLANL--VTLELRENLLKSLPASL 170
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/255 (27%), Positives = 107/255 (41%), Gaps = 34/255 (13%)
Query: 419 LELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSP-ARLPFS 477
LEL +L LP ++ L ++E L L P L L +L+EL L + + LP
Sbjct: 156 LELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215
Query: 478 LQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQL 537
L R L + V L E+P + GL L +L L Q L R + + +LKQL
Sbjct: 216 LGNLRR--LVCLDVSENRLEELPAELGGLVLLTDL----LLSQNLLRRLP-DGIGQLKQL 268
Query: 538 KVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERI 597
+L + N VT+ G + LS EL L L +
Sbjct: 269 SILKVDQNR---LCEVTEAIGDCENLS---------------------ELILTENLLMAL 304
Query: 598 PHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQ 657
P ++ L L L++ NHL ++ + C L L L N++A +P + L
Sbjct: 305 PRSLGKLTKLTNLNVDRNHLEALPPEIG--GCVALSVLSLRDNRLAVLPPELAHTTELHV 362
Query: 658 LYLSYNKLETLPSQL 672
L ++ N+L++LP L
Sbjct: 363 LDVAGNRLQSLPFAL 377
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 106 bits (265), Expect = 7e-23
Identities = 106/345 (30%), Positives = 161/345 (46%), Gaps = 12/345 (3%)
Query: 424 CMLPGLPDTVFELSE-VESLRLEAICDITFPPGLSQLVHLQELSLLHSPA-RLPFSLQVF 481
C L +P+ ++ S +E L L+A P +L++L++L L + RLP + F
Sbjct: 22 CSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANF 81
Query: 482 LRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLS 541
++ L + V ++ E+P + + LE G L T LR L L +
Sbjct: 82 MQ--LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFT--QLRSLAHLALND 137
Query: 542 LRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAV 601
+ A +P V ++A +L L L + + + SL L L +L+L LE +P +
Sbjct: 138 VSLQA--LPGDVGNLA-NLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTL 193
Query: 602 FSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLS 661
+L L+EL L N L ++ L + R+LV L + N++ +P + L L L LS
Sbjct: 194 GALPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLS 251
Query: 662 YNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFC 721
N L LP +G L +L V N L + +G +NL L L+ N L ALP L
Sbjct: 252 QNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKL 311
Query: 722 RKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGN 766
KL L + N L L P +G ALS L L+ NRL LP EL +
Sbjct: 312 TKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAH 356
Score = 106 bits (265), Expect = 7e-23
Identities = 100/313 (31%), Positives = 151/313 (48%), Gaps = 28/313 (8%)
Query: 486 LKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAAT-LESLRELKQLKVLSLRS 544
L+ + + +LRE+P F L L +L GL E+ R + + +L +L V R+
Sbjct: 38 LEELLLDANQLRELPKPFFRLLNLRKL---GLSDNEIQRLPPEVANFMQLVELDVS--RN 92
Query: 545 NAGKVPASV--------TDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLER 596
+ ++P S+ D +G+ LS DG +L +L L L L+
Sbjct: 93 DIPEIPESIKFCKALEIADFSGN--PLSRLPDG--------FTQLRSLAHLALNDVSLQA 142
Query: 597 IPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLE 656
+P V +L L L+L++N L+S+ LSF KL L L N + +P+ + L +L
Sbjct: 143 LPGDVGNLANLVTLELRENLLKSLPASLSF--LVKLEQLDLGGNDLEVLPDTLGALPNLR 200
Query: 657 QLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPE 716
+L+L N+L LP +LG L LDVS N L LP E+G L L L LS N L LP+
Sbjct: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260
Query: 717 ELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLL 776
+ ++L L + N+L +++ +G LS L L N L ALP LG K L
Sbjct: 261 GIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKL--TKLTNLN 318
Query: 777 VEDTLYQGLPAEV 789
V+ + LP E+
Sbjct: 319 VDRNHLEALPPEI 331
Score = 105 bits (262), Expect = 2e-22
Identities = 96/283 (33%), Positives = 135/283 (47%), Gaps = 16/283 (5%)
Query: 507 RGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSL- 565
R LEEL L+ +EL + L L+ L L N ++ +VA +Q + L
Sbjct: 36 RSLEELLLDANQLRELPKP-----FFRLLNLRKLGLSDN--EIQRLPPEVANFMQLVELD 88
Query: 566 --HNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEI 623
ND + S+K AL + L R+P L +L L L D L+++
Sbjct: 89 VSRNDIPEIP--ESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGD 146
Query: 624 LSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDV 683
+ + LVTL L N + +P + L LEQL L N LE LP LG LR L +
Sbjct: 147 VG--NLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWL 204
Query: 684 SHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGA 743
N L +LPPE+G L+ L L +S N LE LP EL L LLL N L +L +G
Sbjct: 205 DRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ 264
Query: 744 LRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLP 786
L+ LS L++ NRL + E +G+C L + L++ + L LP
Sbjct: 265 LKQLSILKVDQNRLCEVTEAIGDCENLSE--LILTENLLMALP 305
Score = 82.4 bits (202), Expect = 1e-15
Identities = 55/152 (36%), Positives = 76/152 (50%), Gaps = 3/152 (1%)
Query: 639 HNQIAYVPEHV-RKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGL 697
H + VPE + R RSLE+L L N+L LP LR L +S N + LPPEV
Sbjct: 21 HCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVAN 80
Query: 698 LQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRL 757
L L +S N + +PE + FC+ L N LS+L LR+L+ L L L
Sbjct: 81 FMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSL 140
Query: 758 EALPEELGNCGGLKKAGLLVEDTLYQGLPAEV 789
+ALP ++GN L L + + L + LPA +
Sbjct: 141 QALPGDVGNLANL--VTLELRENLLKSLPASL 170
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/255 (27%), Positives = 107/255 (41%), Gaps = 34/255 (13%)
Query: 419 LELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSP-ARLPFS 477
LEL +L LP ++ L ++E L L P L L +L+EL L + + LP
Sbjct: 156 LELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215
Query: 478 LQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQL 537
L R L + V L E+P + GL L +L L Q L R + + +LKQL
Sbjct: 216 LGNLRR--LVCLDVSENRLEELPAELGGLVLLTDL----LLSQNLLRRLP-DGIGQLKQL 268
Query: 538 KVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERI 597
+L + N VT+ G + LS EL L L +
Sbjct: 269 SILKVDQNR---LCEVTEAIGDCENLS---------------------ELILTENLLMAL 304
Query: 598 PHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQ 657
P ++ L L L++ NHL ++ + C L L L N++A +P + L
Sbjct: 305 PRSLGKLTKLTNLNVDRNHLEALPPEIG--GCVALSVLSLRDNRLAVLPPELAHTTELHV 362
Query: 658 LYLSYNKLETLPSQL 672
L ++ N+L++LP L
Sbjct: 363 LDVAGNRLQSLPFAL 377
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 105 bits (262), Expect = 2e-22
Identities = 80/217 (36%), Positives = 111/217 (51%), Gaps = 16/217 (7%)
Query: 562 RLSLHNDGARLVA-----------LNSLKKLAALRELELVAC---GLERIPHAVFSLGAL 607
RLS H D L A L SL R L AC L +P + L L
Sbjct: 68 RLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHL 127
Query: 608 QELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLET 667
LDL N L ++ + R L L L HN ++ +PE + L +L L +++N+L+T
Sbjct: 128 AHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQT 185
Query: 668 LPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTL 727
LP LG S L+ LD+S N L +LPPE+G L +L L L+ N L++LP L R LR L
Sbjct: 186 LPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLL 245
Query: 728 LLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEEL 764
+L N L+ + + L L+RL+L+ N+L LP EL
Sbjct: 246 VLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 82.0 bits (201), Expect = 2e-15
Identities = 68/211 (32%), Positives = 99/211 (46%), Gaps = 20/211 (9%)
Query: 580 KLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWH 639
+L+ + +L+ L ++P SL L+ L LK R + C +
Sbjct: 68 RLSTHEDPQLLEATLAQLPQ---SLSCLRSLVLKGGQRRD-----TLGACLR-------- 111
Query: 640 NQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQ 699
+ +P + L L L LS+N LETLP+ + GL L +SHN L LP +G L
Sbjct: 112 GALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALP 171
Query: 700 NLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEA 759
L L +++N L+ LP L L+ L L N L L P +G L +L L L NRL++
Sbjct: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
Query: 760 LPEELGNCGGLKKAGLLV-EDTLYQGLPAEV 789
LP L GL+ LLV L +PA++
Sbjct: 232 LPASL---AGLRSLRLLVLHSNLLASVPADL 259
Score = 45.8 bits (107), Expect = 2e-04
Identities = 62/220 (28%), Positives = 84/220 (38%), Gaps = 55/220 (25%)
Query: 453 PPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEEL 512
P GLS L HL L L L +P V +RGL L
Sbjct: 118 PAGLSGLAHLAHLDL------------------------SFNSLETLPACVLQMRGLGAL 153
Query: 513 HLEGLFPQELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARL 572
L EL E+L L L L++ N LQ L
Sbjct: 154 LLSHNCLSELP-----EALGALPALTFLTVTHN-------------RLQTLP-------- 187
Query: 573 VALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKL 632
+L L+ L+ L+L L+ +P + LG+L EL+L N L+S+ S R L
Sbjct: 188 ---PALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP--ASLAGLRSL 242
Query: 633 VTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQL 672
L L N +A VP + +L L +L L N+L LP +L
Sbjct: 243 RLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 105 bits (262), Expect = 2e-22
Identities = 80/217 (36%), Positives = 111/217 (51%), Gaps = 16/217 (7%)
Query: 562 RLSLHNDGARLVA-----------LNSLKKLAALRELELVAC---GLERIPHAVFSLGAL 607
RLS H D L A L SL R L AC L +P + L L
Sbjct: 68 RLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHL 127
Query: 608 QELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLET 667
LDL N L ++ + R L L L HN ++ +PE + L +L L +++N+L+T
Sbjct: 128 AHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQT 185
Query: 668 LPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTL 727
LP LG S L+ LD+S N L +LPPE+G L +L L L+ N L++LP L R LR L
Sbjct: 186 LPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLL 245
Query: 728 LLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEEL 764
+L N L+ + + L L+RL+L+ N+L LP EL
Sbjct: 246 VLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 82.0 bits (201), Expect = 2e-15
Identities = 68/211 (32%), Positives = 99/211 (46%), Gaps = 20/211 (9%)
Query: 580 KLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWH 639
+L+ + +L+ L ++P SL L+ L LK R + C +
Sbjct: 68 RLSTHEDPQLLEATLAQLPQ---SLSCLRSLVLKGGQRRD-----TLGACLR-------- 111
Query: 640 NQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQ 699
+ +P + L L L LS+N LETLP+ + GL L +SHN L LP +G L
Sbjct: 112 GALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALP 171
Query: 700 NLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEA 759
L L +++N L+ LP L L+ L L N L L P +G L +L L L NRL++
Sbjct: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
Query: 760 LPEELGNCGGLKKAGLLV-EDTLYQGLPAEV 789
LP L GL+ LLV L +PA++
Sbjct: 232 LPASL---AGLRSLRLLVLHSNLLASVPADL 259
Score = 45.8 bits (107), Expect = 2e-04
Identities = 62/220 (28%), Positives = 84/220 (38%), Gaps = 55/220 (25%)
Query: 453 PPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEEL 512
P GLS L HL L L L +P V +RGL L
Sbjct: 118 PAGLSGLAHLAHLDL------------------------SFNSLETLPACVLQMRGLGAL 153
Query: 513 HLEGLFPQELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARL 572
L EL E+L L L L++ N LQ L
Sbjct: 154 LLSHNCLSELP-----EALGALPALTFLTVTHN-------------RLQTLP-------- 187
Query: 573 VALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKL 632
+L L+ L+ L+L L+ +P + LG+L EL+L N L+S+ S R L
Sbjct: 188 ---PALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP--ASLAGLRSL 242
Query: 633 VTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQL 672
L L N +A VP + +L L +L L N+L LP +L
Sbjct: 243 RLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 100 bits (249), Expect = 5e-21
Identities = 72/188 (38%), Positives = 106/188 (56%), Gaps = 4/188 (2%)
Query: 607 LQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLE 666
L+ L +K N L S+ E L+ Q LV L L N I VPE + L L+ L LS N LE
Sbjct: 43 LERLYMKRNSLTSLPENLA-QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALE 101
Query: 667 TLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRT 726
+ ++G LR L +++N L LPPEVG L+ LQ L +S N L LPE L C L+
Sbjct: 102 IVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQY 161
Query: 727 LLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLY-QGL 785
L + N+L + H+ L +L+ L + GNRL LP +LG L+ + V++ ++ +GL
Sbjct: 162 LTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQY--VYVDNNIHLKGL 219
Query: 786 PAEVRDKM 793
P+ + +K+
Sbjct: 220 PSYLYNKV 227
Score = 83.6 bits (205), Expect = 7e-16
Identities = 59/174 (33%), Positives = 93/174 (53%), Gaps = 2/174 (1%)
Query: 559 HLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLR 618
+L+RL + + + N +KL L EL L + + +P A+ SL LQ LDL DN L
Sbjct: 42 YLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALE 101
Query: 619 SIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGL 678
+ R L LRL +NQ+ ++P V L+ L+ L +S N+L TLP +L +C L
Sbjct: 102 IV--CPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSL 159
Query: 679 RLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDN 732
+ L V N L +P + L +L L+++ N L LP +L R+L+ + + +N
Sbjct: 160 QYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
Score = 73.2 bits (178), Expect = 9e-13
Identities = 56/152 (36%), Positives = 76/152 (50%), Gaps = 4/152 (2%)
Query: 624 LSFQHCRKLVTLRLWHNQIAYVPEHVRK---LRSLEQLYLSYNKLETLPSQLG-LCSGLR 679
+S K L L + + + P + K L+ LE+LY+ N L +LP L L
Sbjct: 9 ISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLV 68
Query: 680 LLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSP 739
L + N + +P +G L LQ L LS NALE + E+ R LR L L +NQL L P
Sbjct: 69 ELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPP 128
Query: 740 HVGALRALSRLELKGNRLEALPEELGNCGGLK 771
VG L+ L L++ NRL LPE L C L+
Sbjct: 129 EVGDLKELQTLDISTNRLLTLPERLHMCLSLQ 160
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 96.3 bits (238), Expect = 1e-19
Identities = 61/170 (35%), Positives = 89/170 (52%), Gaps = 4/170 (2%)
Query: 599 HAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQL 658
+ +F+L + +L L N L + ++ + L L ++NQI +P + L+ L+ L
Sbjct: 34 NGLFTLSHITQLVLSHNKLTMVPPNIA--ELKNLEVLNFFNNQIEELPTQISSLQKLKHL 91
Query: 659 YLSYNKLETLPSQLGLCSGLRLLDVSHNGL--HSLPPEVGLLQNLQHLALSYNALEALPE 716
L N+L TLP G L +LD+++N L +SLP L L+ L LS N E LP
Sbjct: 92 NLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPP 151
Query: 717 ELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGN 766
++ KL+ L L DN L L +G L L L ++GNRL LP ELGN
Sbjct: 152 DIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 201
Score = 93.6 bits (231), Expect = 6e-19
Identities = 60/183 (32%), Positives = 97/183 (53%), Gaps = 4/183 (2%)
Query: 609 ELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETL 668
E+D+ D + ++ ++ + L L HN++ VP ++ +L++LE L N++E L
Sbjct: 19 EVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL 78
Query: 669 PSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNAL--EALPEELFFCRKLRT 726
P+Q+ L+ L++ N L++LP G L L+ L L+YN L +LP F+ LR
Sbjct: 79 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 138
Query: 727 LLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLP 786
L L DN L P +G L L L L+ N L +LP+E+G LK+ L ++ LP
Sbjct: 139 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLTVLP 196
Query: 787 AEV 789
E+
Sbjct: 197 PEL 199
Score = 56.2 bits (134), Expect = 1e-07
Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 2/150 (1%)
Query: 549 VPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQ 608
VP ++ ++ +L+ L+ N+ + + L L+ L L L +P SL AL+
Sbjct: 55 VPPNIAELK-NLEVLNFFNNQIEELP-TQISSLQKLKHLNLGMNRLNTLPRGFGSLPALE 112
Query: 609 ELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETL 668
LDL N+L +F + L L L N +P + KL L+ L L N L +L
Sbjct: 113 VLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISL 172
Query: 669 PSQLGLCSGLRLLDVSHNGLHSLPPEVGLL 698
P ++G + L+ L + N L LPPE+G L
Sbjct: 173 PKEIGELTQLKELHIQGNRLTVLPPELGNL 202
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 95.1 bits (235), Expect = 2e-19
Identities = 74/245 (30%), Positives = 125/245 (51%), Gaps = 6/245 (2%)
Query: 529 ESLRELKQLKVLSLRSNAGKV--PASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRE 586
+ + ++K +K L L N K A D+ G L+ LSL +G + + ++ L LR
Sbjct: 158 KDILKIKYVKYLYLDKNQIKTFQGADSGDLLG-LEILSLQENGLSSLP-SEIQLLHNLRI 215
Query: 587 LELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVP 646
L + + IP + LG +++L +N++ + L + L L L N++ ++P
Sbjct: 216 LNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDL--ECLGNLEILSLGKNKLRHIP 273
Query: 647 EHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLAL 706
+ + L++L L L YN+L T P L L LD++ N + SLP E+ L+NL+ L +
Sbjct: 274 DTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLM 333
Query: 707 SYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGN 766
+N L L E+F K++ L L DN+L +S + R L L L N L+ +PE++
Sbjct: 334 DHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISC 393
Query: 767 CGGLK 771
C L+
Sbjct: 394 CAMLE 398
Score = 94.7 bits (234), Expect = 3e-19
Identities = 90/333 (27%), Positives = 158/333 (47%), Gaps = 35/333 (10%)
Query: 478 LQVFLRDHLKVMRVKCEELREVPLWVF-GLRGLEELHLEGLFPQELARAATLESLRELKQ 536
LQ F +D LK+ VK L + + F G + L LE L QE ++ ++ L
Sbjct: 153 LQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHN 212
Query: 537 LKVLSLRSN-AGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACG-- 593
L++L++ N +P ++ + G++++L +N+ N L L LE+++ G
Sbjct: 213 LRILNVSHNHISHIPKEISQL-GNIRQLFFYNNYIE----NFPSDLECLGNLEILSLGKN 267
Query: 594 -LERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKL 652
L IP + SL L+ L+L+ N L + + L F KL++L L N I+ +P+ +R+L
Sbjct: 268 KLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF--LPKLISLDLTGNLISSLPKEIREL 325
Query: 653 RSLE-----------------------QLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLH 689
++LE +L L+ NKLE + ++ LR+L + N L
Sbjct: 326 KNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLK 385
Query: 690 SLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSR 749
++P ++ L+ L+LS N L LP+ + LR L + N + +++ + L +
Sbjct: 386 NIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICS 445
Query: 750 LELKGNRLEALPEELGNCGGLKKAGLLVEDTLY 782
LE GN + +P E+ NC + K L +Y
Sbjct: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMY 478
Score = 84.0 bits (206), Expect = 5e-16
Identities = 96/388 (24%), Positives = 161/388 (41%), Gaps = 48/388 (12%)
Query: 419 LELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSL-------LHSP 471
L L L +PDT+ L + L LE TFP L L L L L L
Sbjct: 262 LSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKE 321
Query: 472 ARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESL 531
R +L+ L DH K+ + E +F L ++EL L + ++ +E+
Sbjct: 322 IRELKNLETLLMDHNKLTFLAVE--------IFQLLKIKELQLADNKLEVISHK--IENF 371
Query: 532 RELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNS-LKKLAALRELELV 590
REL+ +L L N K L+ LSL ++ +L L + KL LR+L +
Sbjct: 372 RELR---ILILDKNLLKNIPEKISCCAMLECLSLSDN--KLTELPKYIHKLNNLRKLHVN 426
Query: 591 ACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVR 650
+ +I + L + L+ N + + + ++C+K++ + L +N+I Y P +
Sbjct: 427 RNNMVKITDCISHLNNICSLEFSGNIITDVP--IEIKNCQKIIKIELSYNKIMYFPLGLC 484
Query: 651 KLRSLEQLYLSYNKLETLPSQLG---------------------LCS--GLRLLDVSHNG 687
L SL L ++ N + +P + CS L+ LD+ N
Sbjct: 485 ALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQ 544
Query: 688 LHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRAL 747
+ +P + + +L L L N E P EL L+ L L +NQL ++S + L+ +
Sbjct: 545 IKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGI 604
Query: 748 SRLELKGNRLEALPEELGNCGGLKKAGL 775
+L N+ P EL L++ +
Sbjct: 605 QKLNFSSNQFIHFPIELCQLQSLEQLNI 632
Score = 83.2 bits (204), Expect = 9e-16
Identities = 95/361 (26%), Positives = 155/361 (42%), Gaps = 36/361 (9%)
Query: 429 LPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSL-----LHSPARLPFSLQVFLR 483
+P + +L + L FP L L +L+ LSL H P LP SL+
Sbjct: 226 IPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLP-SLKT--- 281
Query: 484 DHLKVMRVKCEELREVPLWVFGLRGLEELHLEG----LFPQELARAATLESLR------- 532
L+V+ ++ +L P + L L L L G P+E+ LE+L
Sbjct: 282 --LRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLT 339
Query: 533 -------ELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALR 585
+L ++K L L N +V + + L+ L L + + + + A L
Sbjct: 340 FLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIP-EKISCCAMLE 398
Query: 586 ELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYV 645
L L L +P + L L++L + N++ I + +S H + +L N I V
Sbjct: 399 CLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCIS--HLNNICSLEFSGNIITDV 456
Query: 646 PEHVRKLRSLEQLYLSYNKLETLPSQLGLCS--GLRLLDVSHNGLHSLPPEVGLLQNLQH 703
P ++ + + ++ LSYNK+ P LGLC+ L L V+ N + +P ++ + L H
Sbjct: 457 PIEIKNCQKIIKIELSYNKIMYFP--LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLH 514
Query: 704 LALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEE 763
L LS N L E L+ L LG NQ+ ++ + + +L L L N+ E P E
Sbjct: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574
Query: 764 L 764
L
Sbjct: 575 L 575
Score = 83.2 bits (204), Expect = 9e-16
Identities = 90/359 (25%), Positives = 156/359 (43%), Gaps = 39/359 (10%)
Query: 419 LELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSL 478
L L+ L LP + +L+ + L + + +S HL + L + +
Sbjct: 400 LSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCIS---HLNNICSLEFSGNIITDV 456
Query: 479 QVFLRDHLKVMRVKCE--ELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQ 536
+ +++ K+++++ ++ PL + L L L + G + E+ + KQ
Sbjct: 457 PIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFS-----KQ 511
Query: 537 LKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLER 596
L L L N + + +L+ L L + + + S+ + +L L L E
Sbjct: 512 LLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPA-SISNMISLHVLILCCNKFET 570
Query: 597 IPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLE 656
P + +L LQ LDL +N L+ I + + + + L NQ + P + +L+SLE
Sbjct: 571 FPRELCTLENLQVLDLSENQLQKISSDIC--NLKGIQKLNFSSNQFIHFPIELCQLQSLE 628
Query: 657 QLYLSY---NKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEA 713
QL +S KL LP +L + L+ LD+S+N + +P +G L+NL L +YN
Sbjct: 629 QLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLH-AYN---- 683
Query: 714 LPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKK 772
NQ+S L P + +L L +L L GN L ALP + N LK+
Sbjct: 684 ------------------NQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKE 724
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 94.7 bits (234), Expect = 3e-19
Identities = 57/135 (42%), Positives = 83/135 (61%)
Query: 630 RKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLH 689
R L L L HN ++ +PE + L +L L +++N+L+TLP LG S L+ LD+S N L
Sbjct: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
Query: 690 SLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSR 749
+LPPE+G L +L L L+ N L++LP L R LR L+L N L+ + + L L+R
Sbjct: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
Query: 750 LELKGNRLEALPEEL 764
L+L+ N+L LP EL
Sbjct: 122 LDLRDNQLRDLPPEL 136
Score = 82.4 bits (202), Expect = 1e-15
Identities = 54/140 (38%), Positives = 70/140 (50%), Gaps = 2/140 (1%)
Query: 652 LRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNAL 711
+R L L LS+N L LP LG L L V+HN L +LPP +G L LQ L LS N L
Sbjct: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
Query: 712 EALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLK 771
+ LP E+ L L L N+L L + LR+L L L N L ++P +L L
Sbjct: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
Query: 772 KAGLLVEDTLYQGLPAEVRD 791
+ L D + LP E+ D
Sbjct: 121 RLDL--RDNQLRDLPPELLD 138
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 91.7 bits (226), Expect = 2e-18
Identities = 55/139 (39%), Positives = 75/139 (53%), Gaps = 2/139 (1%)
Query: 630 RKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGL- 688
+ L L ++NQI +P + L+ L+ L L N+L TLP G L +LD+++N L
Sbjct: 10 KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLS 69
Query: 689 -HSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRAL 747
+SLP L L+ L LS N E LP ++ KL+ L L DN L L +G L L
Sbjct: 70 ENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQL 129
Query: 748 SRLELKGNRLEALPEELGN 766
L ++GNRL LP ELGN
Sbjct: 130 KELHIQGNRLTVLPPELGN 148
Score = 81.6 bits (200), Expect = 3e-15
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 4/147 (2%)
Query: 645 VPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHL 704
VP ++ +L++LE L N++E LP+Q+ L+ L++ N L++LP G L L+ L
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
Query: 705 ALSYNALE--ALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPE 762
L+YN L +LP F+ LR L L DN L P +G L L L L+ N L +LP+
Sbjct: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
Query: 763 ELGNCGGLKKAGLLVEDTLYQGLPAEV 789
E+G LK+ L ++ LP E+
Sbjct: 122 EIGELTQLKE--LHIQGNRLTVLPPEL 146
Score = 56.2 bits (134), Expect = 1e-07
Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 2/150 (1%)
Query: 549 VPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQ 608
VP ++ ++ +L+ L+ N+ + + L L+ L L L +P SL AL+
Sbjct: 2 VPPNIAELK-NLEVLNFFNNQIEELP-TQISSLQKLKHLNLGMNRLNTLPRGFGSLPALE 59
Query: 609 ELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETL 668
LDL N+L +F + L L L N +P + KL L+ L L N L +L
Sbjct: 60 VLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISL 119
Query: 669 PSQLGLCSGLRLLDVSHNGLHSLPPEVGLL 698
P ++G + L+ L + N L LPPE+G L
Sbjct: 120 PKEIGELTQLKELHIQGNRLTVLPPELGNL 149
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 90.1 bits (222), Expect = 7e-18
Identities = 67/202 (33%), Positives = 111/202 (54%), Gaps = 11/202 (5%)
Query: 594 LERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLR 653
+ ++P A+ L L+ L L++N + + L + +L TL L +N + VPE ++ L
Sbjct: 26 MTKMPSALGKLPGLKTLVLQNNLIPKVCPELC--NLTQLTTLNLGNNLLEEVPEEMKYLT 83
Query: 654 SLEQLYLSYNKLETLPSQLGLCSGLR---LLDVSHNGLHSLPPEVGLLQNLQHLALSYNA 710
SL+ L+LS N++ G C GL+ LL++++N L LP EV L++L +++++YN
Sbjct: 84 SLKNLHLSGNRICRFAP--GACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQ 141
Query: 711 LEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGL 770
L ++P EL F L L L NQL + + L+ L +L L N + LPEEL + L
Sbjct: 142 LASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCD---L 198
Query: 771 KKAGLL-VEDTLYQGLPAEVRD 791
KK +L + + Q P+ +D
Sbjct: 199 KKLRILDIAGNIIQIFPSGFQD 220
Score = 57.0 bits (136), Expect = 7e-08
Identities = 37/112 (33%), Positives = 57/112 (50%), Gaps = 1/112 (0%)
Query: 660 LSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELF 719
L+ K+ +PS LG GL+ L + +N + + PE+ L L L L N LE +PEE+
Sbjct: 21 LNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMK 80
Query: 720 FCRKLRTLLLGDNQLSQLSPHV-GALRALSRLELKGNRLEALPEELGNCGGL 770
+ L+ L L N++ + +P L+ L L L N L LP+E+ L
Sbjct: 81 YLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSL 132
Score = 43.5 bits (101), Expect = 8e-04
Identities = 33/112 (29%), Positives = 54/112 (48%), Gaps = 3/112 (2%)
Query: 679 RLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLS 738
+++ ++ + +P +G L L+ L L N + + EL +L TL LG+N L ++
Sbjct: 17 KIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVP 76
Query: 739 PHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLL-VEDTLYQGLPAEV 789
+ L +L L L GNR+ G C GL+ LL + + LP EV
Sbjct: 77 EEMKYLTSLKNLHLSGNRICRFAP--GACDGLQNLILLNLNNNHLTQLPQEV 126
Score = 36.6 bits (83), Expect = 0.094
Identities = 23/77 (29%), Positives = 39/77 (50%)
Query: 699 QNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLE 758
+N + + L+ + +P L L+TL+L +N + ++ P + L L+ L L N LE
Sbjct: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
Query: 759 ALPEELGNCGGLKKAGL 775
+PEE+ LK L
Sbjct: 74 EVPEEMKYLTSLKNLHL 90
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 90.1 bits (222), Expect = 7e-18
Identities = 103/385 (26%), Positives = 173/385 (44%), Gaps = 48/385 (12%)
Query: 418 RLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPAR-LPF 476
RL L+ L LP + + ++ L + T PP L+ + L+ L L + R LP
Sbjct: 201 RLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE 260
Query: 477 ---------------SLQVFLRDHLK------VMRVKCEELREVPLWVFGLRGLEELHLE 515
+++ +HLK V+ ++ +L+ VP + LR LE L L
Sbjct: 261 FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLS 320
Query: 516 GLFPQELARAATLESLRELKQLKVLSLRSNAGK------VPASVTDVAGHLQRLSLHNDG 569
L SL L LK L+L N + + +V +L R + +DG
Sbjct: 321 NNDISSLPY-----SLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYL-RSKIKDDG 373
Query: 570 ARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSI-EEILSFQH 628
S + A + L + I HA+ +L + LD D I +E+
Sbjct: 374 P------SQSESATETAMTLPSESRVNI-HAIITL---KILDYSDKQATLIPDEVFDAVK 423
Query: 629 CRKLVTLRLWHNQIAYVPEHVRKLRSL-EQLYLSYNKLETLPSQLGLCSGLRLLDVSHNG 687
+ ++ NQ+ +P+ + +L+ + + LS+NKL + +L + L LD+ +N
Sbjct: 424 SNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNF 483
Query: 688 LHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPH-VGALRA 746
L+SLP E+ L LQ + LS+N + LPE L+ L T+L+ +NQ+ + P + +
Sbjct: 484 LNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMEN 543
Query: 747 LSRLELKGNRLEALPEELGNCGGLK 771
L+ L+L+ N L +P ELGNC L+
Sbjct: 544 LTTLDLQNNDLLQIPPELGNCVNLR 568
Score = 89.4 bits (220), Expect = 1e-17
Identities = 57/169 (33%), Positives = 90/169 (53%), Gaps = 3/169 (1%)
Query: 604 LGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYN 663
L AL LD+ DN L S+ + + L L + HN++ +PE + LR+L+ LYL +N
Sbjct: 104 LPALTVLDIHDNQLTSLPSAI--RELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHN 161
Query: 664 KLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRK 723
+L + S L LD+S+N L ++P L +L L LS N L++LP E+ ++
Sbjct: 162 ELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKR 221
Query: 724 LRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKK 772
L+ L N L + P + + +L L L+ N+L LP E +C LK+
Sbjct: 222 LKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP-EFPSCSLLKE 269
Score = 77.8 bits (190), Expect = 4e-14
Identities = 49/135 (36%), Positives = 72/135 (53%), Gaps = 2/135 (1%)
Query: 655 LEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEAL 714
L +L +S NKL++L L L L +LD+ N L SLP + L+NLQ L +S+N L+ L
Sbjct: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
Query: 715 PEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAG 774
PEE+ R L+ L L N+L+ +S L L L+L N L +P + L +
Sbjct: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
Query: 775 LLVEDTLYQGLPAEV 789
L + + LPAE+
Sbjct: 204 LSSNE--LKSLPAEI 216
Score = 73.6 bits (179), Expect = 7e-13
Identities = 60/212 (28%), Positives = 98/212 (46%), Gaps = 4/212 (1%)
Query: 578 LKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRL 637
LK +L L L +P V+ + ++ + N S + L L +
Sbjct: 32 LKAARKSGQLNLSGRNLSEVPQCVWRINV--DIPEEANQNLSFGATERWWEQTDLTKLII 89
Query: 638 WHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGL 697
+N++ + + +R L +L L + N+L +LPS + L+ L+VSHN L LP E+
Sbjct: 90 SNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITN 149
Query: 698 LQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRL 757
L+NL+ L L +N L + E L L L +N L+ + +L +L RL L N L
Sbjct: 150 LRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNEL 209
Query: 758 EALPEELGNCGGLKKAGLLVEDTLYQGLPAEV 789
++LP E+ LK L L + +P E+
Sbjct: 210 KSLPAEINRMKRLKH--LDCNSNLLETIPPEL 239
Score = 58.5 bits (140), Expect = 2e-08
Identities = 43/129 (33%), Positives = 69/129 (53%), Gaps = 7/129 (5%)
Query: 607 LQELDLKDNHLRSIEEILSFQHC--RKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNK 664
+ ++DL N L +S + C +KL L L +N + +PE + L L+ + LS+N+
Sbjct: 451 VSDVDLSFNKL----SFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNR 506
Query: 665 LETLPSQLGLCSGLRLLDVSHNGLHSLPPE-VGLLQNLQHLALSYNALEALPEELFFCRK 723
+ LP L L + +S+N + S+ P+ + +++NL L L N L +P EL C
Sbjct: 507 FKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVN 566
Query: 724 LRTLLLGDN 732
LRTLLL N
Sbjct: 567 LRTLLLDGN 575
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 87.4 bits (215), Expect = 5e-17
Identities = 59/182 (32%), Positives = 92/182 (50%), Gaps = 6/182 (3%)
Query: 597 IPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLE 656
+P ++ L LQE L L I E + + L+ L L N I+ +P + L L+
Sbjct: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIG--RFQNLIVLDLSRNTISEIPPGIGLLTRLQ 132
Query: 657 QLYLSYNKLETLPSQLGLCSGLRLLDVSHN-GLHSLPPEVGLLQNLQHLALSYNALEALP 715
+L LSYNK++T+P +L C+ L L+++ N + LP E+ L L HL LS N +P
Sbjct: 133 ELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIP 192
Query: 716 EELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGL 775
+ L L +G N+L QL + ++ L L L+ N + LP+ + N +K G
Sbjct: 193 LAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN---MKNLGT 249
Query: 776 LV 777
LV
Sbjct: 250 LV 251
Score = 72.0 bits (175), Expect = 2e-12
Identities = 71/258 (27%), Positives = 111/258 (43%), Gaps = 12/258 (4%)
Query: 510 EELHLEGLFPQELARA----ATLESLRELKQLK----VLSLRSNAGKVPASVTDVAGHLQ 561
E+L E F +L R +L LRE + +L + K S LQ
Sbjct: 27 EDLKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQ 86
Query: 562 RLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIE 621
LH G + + + L L+L + IP + L LQEL L N ++++
Sbjct: 87 EWQLHRTGLLKIP-EFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVP 145
Query: 622 EILSFQHCRKLVTLRLWHNQ-IAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRL 680
+ LS +C L L L N+ I +P+ + L L L LS N T+P + L
Sbjct: 146 KELS--NCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEW 203
Query: 681 LDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPH 740
LD+ N L LP + +QNL L L N + LP+ + + L TL+L +N+L +
Sbjct: 204 LDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVC 263
Query: 741 VGALRALSRLELKGNRLE 758
+ + L + + N L+
Sbjct: 264 MEEMANLRFVNFRDNPLK 281
Score = 71.2 bits (173), Expect = 3e-12
Identities = 51/172 (29%), Positives = 83/172 (48%), Gaps = 8/172 (4%)
Query: 608 QELDLKDNHLRSIEEILSFQHCRKLVT-------LRLWHNQIAYVPEHVRKLRSLEQLYL 660
+E + + +R EE +S R+ VT L++ + +P + KL L++ L
Sbjct: 31 REKEFQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQL 90
Query: 661 SYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFF 720
L +P +G L +LD+S N + +PP +GLL LQ L LSYN ++ +P+EL
Sbjct: 91 HRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSN 150
Query: 721 CRKLRTLLLGDNQ-LSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLK 771
C L L L N+ + L + L L+ L+L N +P + N L+
Sbjct: 151 CASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALE 202
Score = 55.8 bits (133), Expect = 1e-07
Identities = 49/171 (28%), Positives = 75/171 (43%), Gaps = 30/171 (17%)
Query: 626 FQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLE--TLPSQLGLCSGLRLLDV 683
FQH KLV R+W +++ + R ++ L K E TLPS L + L+ +
Sbjct: 35 FQH--KLV--RIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQL 90
Query: 684 SHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGA 743
GL +P +G QNL L LS N + +P P +G
Sbjct: 91 HRTGLLKIPEFIGRFQNLIVLDLSRNTISEIP-----------------------PGIGL 127
Query: 744 LRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLPAEVRDKME 794
L L L L N+++ +P+EL NC L+K L V + LP E+ + ++
Sbjct: 128 LTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICD-LPQELSNLLK 177
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 85.9 bits (211), Expect = 1e-16
Identities = 61/201 (30%), Positives = 101/201 (50%), Gaps = 4/201 (1%)
Query: 589 LVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEH 648
LV G+ IP ++ L +Q+L+L N LR + + ++V L L N++ +P
Sbjct: 55 LVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVG--KLTRIVVLNLCGNRLKSLPRE 112
Query: 649 VRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSY 708
V L+ L+ L+++ N L +P++L LC L +L +SHN L LP L L+ L LS
Sbjct: 113 VSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSN 172
Query: 709 NALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCG 768
N +P +F ++L L +G N+L ++ + L +L +GN + + P L
Sbjct: 173 NFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVT 232
Query: 769 GLKKAGLLVEDTLYQGLPAEV 789
L+ L D Q LP+E+
Sbjct: 233 SLELLNLNNND--IQTLPSEL 251
Score = 59.3 bits (142), Expect = 1e-08
Identities = 80/277 (28%), Positives = 111/277 (40%), Gaps = 66/277 (23%)
Query: 429 LPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKV 488
+PD ++ LSEV+ L L PP + +L + L+L + + +V L LKV
Sbjct: 63 IPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLK-SLPREVSLLQCLKV 121
Query: 489 MRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNA-G 547
+ V L EVP EL L ++L+VLSL N
Sbjct: 122 LFVNMNCLTEVP---------AELSL-------------------CRKLEVLSLSHNCLS 153
Query: 548 KVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGAL 607
++PA D L+ LR+L L IP VFSL L
Sbjct: 154 QLPACFAD-------------------------LSRLRKLNLSNNFFAHIPMCVFSLKEL 188
Query: 608 QELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLET 667
L + N L +I E S QH L N I P + + SLE L L+ N ++T
Sbjct: 189 IFLHVGSNRLENIAE--SIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQT 246
Query: 668 LPSQLG-LCSGLRL--------LDVSHNGLHSLPPEV 695
LPS+L LC +R+ L +SHN L PE+
Sbjct: 247 LPSELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPEL 283
Score = 58.5 bits (140), Expect = 2e-08
Identities = 52/190 (27%), Positives = 87/190 (45%), Gaps = 27/190 (14%)
Query: 560 LQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRS 619
+Q+L+L ++ R++ + KL + L L L+ +P V L L+ L + N L
Sbjct: 73 VQKLNLSHNQLRVLP-PEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTE 131
Query: 620 IEEILSFQHCRKLVTLRLWHNQI-----------------------AYVPEHVRKLRSLE 656
+ LS CRKL L L HN + A++P V L+ L
Sbjct: 132 VPAELSL--CRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELI 189
Query: 657 QLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPE 716
L++ N+LE + + + L++ N +HS P + L+ +L+ L L+ N ++ LP
Sbjct: 190 FLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPS 249
Query: 717 EL-FFCRKLR 725
EL CR +R
Sbjct: 250 ELHLLCRLVR 259
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 84.7 bits (208), Expect = 3e-16
Identities = 88/338 (26%), Positives = 140/338 (41%), Gaps = 57/338 (16%)
Query: 428 GLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPA-RLPFSLQVFLRDHL 486
G+PD +F+L ++ L L P L ++ L+L H+ +P L + L D L
Sbjct: 95 GVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLL 154
Query: 487 KVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNA 546
+ L E LE L PQ +R L L+ L L N
Sbjct: 155 YL-------------------DLSENRLESLPPQ----------MRRLVHLQTLVLNGNP 185
Query: 547 GKVPASVTDVAGHLQRLSLHNDGARLVALN---SLKKLAALRELELVACGLERIPHAVFS 603
+ A + + +LH + N SL+ L+ L +++L L R+P +++
Sbjct: 186 -LLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYT 244
Query: 604 LGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYN 663
L +L+ L+L N + + L + TL L NQ+ +P + KL L++LYL+ N
Sbjct: 245 LPSLRRLNLSSNQITELS--LCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSN 302
Query: 664 KLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRK 723
KL+ LP +G L NL+ + N LE +PE L C K
Sbjct: 303 KLD---------------------FDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPK 341
Query: 724 LRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALP 761
LR L+L N L L + L + L+++ N +P
Sbjct: 342 LRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
Score = 75.5 bits (184), Expect = 2e-13
Identities = 62/208 (29%), Positives = 106/208 (50%), Gaps = 6/208 (2%)
Query: 577 SLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLR 636
++K + +LR L+L GL +P + +L L+ L + N+L ++ LS + + R
Sbjct: 28 NVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVAR 87
Query: 637 LWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVG 696
+ + VP+ + KL L L LS+N+L P +L + +L++SHN + ++P ++
Sbjct: 88 ANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLF 147
Query: 697 L-LQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQL--SQLSPHVGALRALSRLELK 753
+ L +L +L LS N LE+LP ++ L+TL+L N L +QL + A+ AL L L+
Sbjct: 148 INLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLR-QLPAMTALQTLHLR 206
Query: 754 GNR--LEALPEELGNCGGLKKAGLLVED 779
+ LP L L L D
Sbjct: 207 STQRTQSNLPTSLEGLSNLADVDLSCND 234
Score = 63.9 bits (154), Expect = 6e-10
Identities = 70/258 (27%), Positives = 106/258 (41%), Gaps = 11/258 (4%)
Query: 522 LARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKL 581
L + + + +L L VL L N + A ++ L+L ++ + L
Sbjct: 91 LKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINL 150
Query: 582 AALRELELVACGLERIPHAVFSLGALQELDLKDN-----HLRSIEEILSFQHCRKLVTLR 636
L L+L LE +P + L LQ L L N LR + + + Q T R
Sbjct: 151 TDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQR 210
Query: 637 LWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVG 696
N +P + L +L + LS N L +P L LR L++S N + L +
Sbjct: 211 TQSN----LPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCID 266
Query: 697 LLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLS--QLSPHVGALRALSRLELKG 754
+++ L LS N L +LP + KL+ L L N+L L +G L L
Sbjct: 267 QWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAAN 326
Query: 755 NRLEALPEELGNCGGLKK 772
N LE +PE L C L+K
Sbjct: 327 NNLELVPESLCRCPKLRK 344
Score = 58.2 bits (139), Expect = 3e-08
Identities = 38/123 (30%), Positives = 63/123 (51%), Gaps = 2/123 (1%)
Query: 644 YVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQH 703
Y PE+V+ + SL L L+ L LP +L L L VSHN L +L E+ L +L+
Sbjct: 24 YFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRA 83
Query: 704 LALSYNALE--ALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALP 761
+ N+L+ +P+++F L L L NQL++ + + + L L N ++ +P
Sbjct: 84 IVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIP 143
Query: 762 EEL 764
+L
Sbjct: 144 NQL 146
Score = 53.5 bits (127), Expect = 7e-07
Identities = 71/303 (23%), Positives = 126/303 (41%), Gaps = 28/303 (9%)
Query: 393 LKQLNLNHEWTPEKLRQKLQRNAAGRLELALCMLPGLPDTVF-ELSEVESLRLEAICDIT 451
L L+L+H E R+ L L+ + +P+ +F L+++ L L +
Sbjct: 106 LSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLES 165
Query: 452 FPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEE 511
PP + +LVHLQ L L +P + +LR++P + L+
Sbjct: 166 LPPQMRRLVHLQTLVLNGNP-------------------LLHAQLRQLP----AMTALQT 202
Query: 512 LHLEGLFPQELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGAR 571
LHL + +LE L L + + ++ +VP + + L+RL+L ++
Sbjct: 203 LHLRSTQRTQSNLPTSLEGLSNLADVDLSC--NDLTRVPECLYTLPS-LRRLNLSSNQIT 259
Query: 572 LVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRK 631
++L + + + L L L +P A+ L L++L L N L
Sbjct: 260 ELSL-CIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTN 318
Query: 632 LVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSL 691
L +N + VPE + + L +L L+ N L TLP + + + +LDV N +
Sbjct: 319 LEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVM 378
Query: 692 PPE 694
PP+
Sbjct: 379 PPK 381
Score = 52.8 bits (125), Expect = 1e-06
Identities = 36/100 (36%), Positives = 51/100 (51%), Gaps = 2/100 (2%)
Query: 669 PSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLL 728
P + + LR L ++ GL LP E+ LQ L+HL++S+N L L EL LR ++
Sbjct: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
Query: 729 LGDNQL--SQLSPHVGALRALSRLELKGNRLEALPEELGN 766
N L S + + L LS L+L N+L P EL N
Sbjct: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELEN 125
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,733,677
Number of Sequences: 37866
Number of extensions: 1339860
Number of successful extensions: 5592
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 108
Number of HSP's successfully gapped in prelim test: 165
Number of HSP's that attempted gapping in prelim test: 3909
Number of HSP's gapped (non-prelim): 834
length of query: 796
length of database: 18,247,518
effective HSP length: 110
effective length of query: 686
effective length of database: 14,082,258
effective search space: 9660428988
effective search space used: 9660428988
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.