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Search of human proteins with 40018627
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40018627 MAP kinase-interacting serine/threonine kinase 2
isoform 2 [Homo sapiens]
(465 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40018627 MAP kinase-interacting serine/threonine kinase 2 iso... 948 0.0
gi|40018631 MAP kinase-interacting serine/threonine kinase 2 iso... 796 0.0
gi|207113186 MAP kinase-interacting serine/threonine kinase 1 is... 602 e-172
gi|21361101 MAP kinase-interacting serine/threonine kinase 1 iso... 582 e-166
gi|39752689 MAP kinase-interacting serine/threonine kinase 1 iso... 530 e-151
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 193 2e-49
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 193 2e-49
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 184 2e-46
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 184 2e-46
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 182 6e-46
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 182 6e-46
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 182 7e-46
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 181 1e-45
gi|21237768 MAP kinase-activated protein kinase 5 isoform 2 [Hom... 180 3e-45
gi|21237765 MAP kinase-activated protein kinase 5 isoform 1 [Hom... 180 3e-45
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 179 5e-45
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 178 1e-44
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 177 2e-44
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 176 3e-44
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 176 3e-44
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 176 3e-44
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 176 3e-44
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 176 3e-44
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 176 3e-44
gi|27901803 protein serine kinase H1 [Homo sapiens] 176 4e-44
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 175 9e-44
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 175 9e-44
gi|26051204 calcium/calmodulin-dependent protein kinase II beta ... 174 1e-43
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ... 174 1e-43
gi|26051214 calcium/calmodulin-dependent protein kinase II beta ... 174 1e-43
>gi|40018627 MAP kinase-interacting serine/threonine kinase 2
isoform 2 [Homo sapiens]
Length = 465
Score = 948 bits (2451), Expect = 0.0
Identities = 465/465 (100%), Positives = 465/465 (100%)
Query: 1 MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK 60
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
Sbjct: 1 MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK 60
Query: 61 KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG 120
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
Sbjct: 61 KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG 120
Query: 121 HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL 180
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
Sbjct: 121 HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL 180
Query: 181 EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS 240
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
Sbjct: 181 EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS 240
Query: 241 PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG 300
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
Sbjct: 241 PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG 300
Query: 301 SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA 360
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
Sbjct: 301 SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA 360
Query: 361 QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG 420
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
Sbjct: 361 QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG 420
Query: 421 QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA 465
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
Sbjct: 421 QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA 465
>gi|40018631 MAP kinase-interacting serine/threonine kinase 2
isoform 1 [Homo sapiens]
Length = 414
Score = 796 bits (2057), Expect = 0.0
Identities = 385/385 (100%), Positives = 385/385 (100%)
Query: 1 MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK 60
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
Sbjct: 1 MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK 60
Query: 61 KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG 120
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
Sbjct: 61 KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG 120
Query: 121 HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL 180
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
Sbjct: 121 HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL 180
Query: 181 EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS 240
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
Sbjct: 181 EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS 240
Query: 241 PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG 300
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
Sbjct: 241 PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG 300
Query: 301 SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA 360
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
Sbjct: 301 SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA 360
Query: 361 QVLQHPWVQGCAPENTLPTPMVLQR 385
QVLQHPWVQGCAPENTLPTPMVLQR
Sbjct: 361 QVLQHPWVQGCAPENTLPTPMVLQR 385
>gi|207113186 MAP kinase-interacting serine/threonine kinase 1
isoform 3 [Homo sapiens]
Length = 424
Score = 602 bits (1551), Expect = e-172
Identities = 295/407 (72%), Positives = 343/407 (84%), Gaps = 10/407 (2%)
Query: 47 DMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLIT 106
+M +S+P+ I D +R KKK+RGRATDS G+FED+Y+L ++LGEGA+A+VQ ++L
Sbjct: 12 EMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQN 71
Query: 107 SQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGS 166
+EYAVKIIEKQ GH RSRVFREVE LYQCQG++N+LELIEFFE++ RFYLVFEK++GGS
Sbjct: 72 GKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGS 131
Query: 167 ILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICD 226
IL+HI K++HFNE EAS VV+DVA+ALDFLH KGIAHRDLKPENILCE P +VSPVKICD
Sbjct: 132 ILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICD 191
Query: 227 FDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILY 286
FDLGSG+KLN C+PI+TPEL TPCGSAEYMAPEVVE F+++A+ YDKRCDLWSLGV+LY
Sbjct: 192 FDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLY 251
Query: 287 ILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLIS 346
I+LSGYPPFVG CG+DCGWDRGE C CQN LFESIQEGKYEFPDKDWAHIS AKDLIS
Sbjct: 252 IMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLIS 311
Query: 347 KLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQL 406
KLLVRDAKQRLSAAQVLQHPWVQG APE LPTP VLQRNS DLT FAAEAIA+NRQL
Sbjct: 312 KLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQL 371
Query: 407 AQHDE-DLAEEEAAGQGQPVLVRATSRC-LQLSPPSQSKLAQRRQRA 451
+QH+E +LAEE A A C ++LSPP +S+LA+RR A
Sbjct: 372 SQHEENELAEEPEA--------LADGLCSMKLSPPCKSRLARRRALA 410
>gi|21361101 MAP kinase-interacting serine/threonine kinase 1
isoform 1 [Homo sapiens]
Length = 465
Score = 582 bits (1499), Expect = e-166
Identities = 295/448 (65%), Positives = 343/448 (76%), Gaps = 51/448 (11%)
Query: 47 DMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLIT 106
+M +S+P+ I D +R KKK+RGRATDS G+FED+Y+L ++LGEGA+A+VQ ++L
Sbjct: 12 EMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQN 71
Query: 107 SQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGS 166
+EYAVKIIEKQ GH RSRVFREVE LYQCQG++N+LELIEFFE++ RFYLVFEK++GGS
Sbjct: 72 GKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGS 131
Query: 167 ILSHIHKRRHFNELEASVVVQDVASALDFLHNK--------------------------- 199
IL+HI K++HFNE EAS VV+DVA+ALDFLH K
Sbjct: 132 ILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGS 191
Query: 200 --------------GIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTP 245
GIAHRDLKPENILCE P +VSPVKICDFDLGSG+KLN C+PI+TP
Sbjct: 192 SDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTP 251
Query: 246 ELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGW 305
EL TPCGSAEYMAPEVVE F+++A+ YDKRCDLWSLGV+LYI+LSGYPPFVG CG+DCGW
Sbjct: 252 ELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGW 311
Query: 306 DRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQH 365
DRGE C CQN LFESIQEGKYEFPDKDWAHIS AKDLISKLLVRDAKQRLSAAQVLQH
Sbjct: 312 DRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQH 371
Query: 366 PWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDE-DLAEEEAAGQGQP 424
PWVQG APE LPTP VLQRNS DLT FAAEAIA+NRQL+QH+E +LAEE A
Sbjct: 372 PWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEA----- 426
Query: 425 VLVRATSRC-LQLSPPSQSKLAQRRQRA 451
A C ++LSPP +S+LA+RR A
Sbjct: 427 ---LADGLCSMKLSPPCKSRLARRRALA 451
>gi|39752689 MAP kinase-interacting serine/threonine kinase 1
isoform 2 [Homo sapiens]
Length = 347
Score = 530 bits (1366), Expect = e-151
Identities = 248/324 (76%), Positives = 287/324 (88%)
Query: 47 DMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLIT 106
+M +S+P+ I D +R KKK+RGRATDS G+FED+Y+L ++LGEGA+A+VQ ++L
Sbjct: 12 EMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQN 71
Query: 107 SQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGS 166
+EYAVKIIEKQ GH RSRVFREVE LYQCQG++N+LELIEFFE++ RFYLVFEK++GGS
Sbjct: 72 GKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGS 131
Query: 167 ILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICD 226
IL+HI K++HFNE EAS VV+DVA+ALDFLH KGIAHRDLKPENILCE P +VSPVKICD
Sbjct: 132 ILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICD 191
Query: 227 FDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILY 286
FDLGSG+KLN C+PI+TPEL TPCGSAEYMAPEVVE F+++A+ YDKRCDLWSLGV+LY
Sbjct: 192 FDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLY 251
Query: 287 ILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLIS 346
I+LSGYPPFVG CG+DCGWDRGE C CQN LFESIQEGKYEFPDKDWAHIS AKDLIS
Sbjct: 252 IMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLIS 311
Query: 347 KLLVRDAKQRLSAAQVLQHPWVQG 370
KLLVRDAKQRLSAAQVLQHPWVQG
Sbjct: 312 KLLVRDAKQRLSAAQVLQHPWVQG 335
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 193 bits (491), Expect = 2e-49
Identities = 128/378 (33%), Positives = 192/378 (50%), Gaps = 59/378 (15%)
Query: 79 FEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQG 138
F D Y+++ED+ G G+++ + C++ T EYAVKII+K + E+E+L +
Sbjct: 419 FTDGYEIKEDI-GVGSYSVCKRCVHKATDTEYAVKIIDKS----KRDPSEEIEILLRYGQ 473
Query: 139 HRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHN 198
H N++ L + +++ YLV E MRGG +L I ++R+F+E EAS V+ + +D+LH+
Sbjct: 474 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHS 533
Query: 199 KGIAHRDLKPENILC-EHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYM 257
+G+ HRDLKP NIL + +++CDF ++ L+TPC +A ++
Sbjct: 534 QGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGL-------LMTPCYTANFV 586
Query: 258 APEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNM 317
APEV++ YD CD+WSLG++LY +L+G+ PF G D D E
Sbjct: 587 APEVLKRQG-----YDAACDIWSLGILLYTMLAGFTPFAN--GPD---DTPEE------- 629
Query: 318 LFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTL 377
+ I GKY +W IS AAKD++SK+L D QRL+A QVL+HPWV
Sbjct: 630 ILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV----VNREY 685
Query: 378 PTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLS 437
+P L R + AA A+NR T + +L
Sbjct: 686 LSPNQLSRQDVHLVKGAMAATYFALNR-------------------------TPQAPRLE 720
Query: 438 PPSQSKLAQRRQRASLSS 455
P S LAQRR L+S
Sbjct: 721 PVLSSNLAQRRGMKRLTS 738
Score = 107 bits (266), Expect = 3e-23
Identities = 89/288 (30%), Positives = 139/288 (48%), Gaps = 43/288 (14%)
Query: 89 VLGEGAHARVQTCINLITS---QEYAVKIIEKQPGHIRSRVFREVEMLYQCQ-GHRNVLE 144
VLG+G++ +V + S Q YA+K+++K +R RV ++E + H +++
Sbjct: 72 VLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVK 131
Query: 145 LIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHR 204
L F+ E + YL+ + +RGG + + + K F E + + ++A ALD LH+ GI +R
Sbjct: 132 LHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYR 191
Query: 205 DLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEA 264
DLKPENIL + +KI DF L S ++ D S CG+ EYMAPEVV
Sbjct: 192 DLKPENILLDEEGH---IKITDFGL-SKEAIDHDKRAYSF------CGTIEYMAPEVVNR 241
Query: 265 FSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQE 324
S D WS GV+++ +L+G PF G+ DR E I +
Sbjct: 242 RGHTQS-----ADWWSFGVLMFEMLTGSLPFQGK-------DRKET--------MALILK 281
Query: 325 GKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA-----QVLQHPW 367
K P +S A+ L+ L R+ RL A ++ +HP+
Sbjct: 282 AKLGMPQ----FLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPF 325
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 193 bits (491), Expect = 2e-49
Identities = 128/378 (33%), Positives = 192/378 (50%), Gaps = 59/378 (15%)
Query: 79 FEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQG 138
F D Y+++ED+ G G+++ + C++ T EYAVKII+K + E+E+L +
Sbjct: 411 FTDGYEIKEDI-GVGSYSVCKRCVHKATDTEYAVKIIDKS----KRDPSEEIEILLRYGQ 465
Query: 139 HRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHN 198
H N++ L + +++ YLV E MRGG +L I ++R+F+E EAS V+ + +D+LH+
Sbjct: 466 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHS 525
Query: 199 KGIAHRDLKPENILC-EHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYM 257
+G+ HRDLKP NIL + +++CDF ++ L+TPC +A ++
Sbjct: 526 QGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGL-------LMTPCYTANFV 578
Query: 258 APEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNM 317
APEV++ YD CD+WSLG++LY +L+G+ PF G D D E
Sbjct: 579 APEVLKRQG-----YDAACDIWSLGILLYTMLAGFTPFAN--GPD---DTPEE------- 621
Query: 318 LFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTL 377
+ I GKY +W IS AAKD++SK+L D QRL+A QVL+HPWV
Sbjct: 622 ILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV----VNREY 677
Query: 378 PTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLS 437
+P L R + AA A+NR T + +L
Sbjct: 678 LSPNQLSRQDVHLVKGAMAATYFALNR-------------------------TPQAPRLE 712
Query: 438 PPSQSKLAQRRQRASLSS 455
P S LAQRR L+S
Sbjct: 713 PVLSSNLAQRRGMKRLTS 730
Score = 107 bits (266), Expect = 3e-23
Identities = 89/288 (30%), Positives = 139/288 (48%), Gaps = 43/288 (14%)
Query: 89 VLGEGAHARVQTCINLITS---QEYAVKIIEKQPGHIRSRVFREVEMLYQCQ-GHRNVLE 144
VLG+G++ +V + S Q YA+K+++K +R RV ++E + H +++
Sbjct: 64 VLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVK 123
Query: 145 LIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHR 204
L F+ E + YL+ + +RGG + + + K F E + + ++A ALD LH+ GI +R
Sbjct: 124 LHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYR 183
Query: 205 DLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEA 264
DLKPENIL + +KI DF L S ++ D S CG+ EYMAPEVV
Sbjct: 184 DLKPENILLDEEGH---IKITDFGL-SKEAIDHDKRAYSF------CGTIEYMAPEVVNR 233
Query: 265 FSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQE 324
S D WS GV+++ +L+G PF G+ DR E I +
Sbjct: 234 RGHTQS-----ADWWSFGVLMFEMLTGSLPFQGK-------DRKET--------MALILK 273
Query: 325 GKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA-----QVLQHPW 367
K P +S A+ L+ L R+ RL A ++ +HP+
Sbjct: 274 AKLGMPQ----FLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPF 317
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 184 bits (466), Expect = 2e-46
Identities = 106/315 (33%), Positives = 167/315 (53%), Gaps = 33/315 (10%)
Query: 58 DAKKRGKKKKRGRATDSFSGR---FEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKI 114
D K R + G+ F D Y ++E + G G+++ + C++ T+ EYAVK+
Sbjct: 399 DGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETI-GVGSYSECKRCVHKATNMEYAVKV 457
Query: 115 IEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKR 174
I+K + E+E+L + H N++ L + +++ YLV E MRGG +L I ++
Sbjct: 458 IDKS----KRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQ 513
Query: 175 RHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENIL-CEHPNQVSPVKICDFDLGSGI 233
+ F+E EAS V+ + +++LH++G+ HRDLKP NIL + ++ICDF +
Sbjct: 514 KFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL 573
Query: 234 KLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYP 293
+ L+TPC +A ++APEV++ YD+ CD+WSLG++LY +L+GY
Sbjct: 574 RAENGL-------LMTPCYTANFVAPEVLKRQG-----YDEGCDIWSLGILLYTMLAGYT 621
Query: 294 PFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDA 353
PF + I GK+ +W +S AKDL+SK+L D
Sbjct: 622 PFANGPSD------------TPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 669
Query: 354 KQRLSAAQVLQHPWV 368
QRL+A QVLQHPWV
Sbjct: 670 HQRLTAKQVLQHPWV 684
Score = 101 bits (252), Expect = 1e-21
Identities = 70/215 (32%), Positives = 113/215 (52%), Gaps = 21/215 (9%)
Query: 89 VLGEGAHARVQTCINLITSQE----YAVKIIEKQPGHIRSRVFREVEM-LYQCQGHRNVL 143
VLG+G+ +V + +T + YA+K+++K +R RV ++E + H V+
Sbjct: 76 VLGQGSFGKV-FLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVV 134
Query: 144 ELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAH 203
+L F+ E + YL+ + +RGG + + + K F E + + ++A LD LH+ GI +
Sbjct: 135 KLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIY 194
Query: 204 RDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVE 263
RDLKPENIL + +K+ DF L S ++ + S CG+ EYMAPEVV
Sbjct: 195 RDLKPENILLDEEGH---IKLTDFGL-SKEAIDHEKKAYSF------CGTVEYMAPEVVN 244
Query: 264 AFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGR 298
S D WS GV+++ +L+G PF G+
Sbjct: 245 RQGHSHS-----ADWWSYGVLMFEMLTGSLPFQGK 274
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 184 bits (466), Expect = 2e-46
Identities = 106/315 (33%), Positives = 167/315 (53%), Gaps = 33/315 (10%)
Query: 58 DAKKRGKKKKRGRATDSFSGR---FEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKI 114
D K R + G+ F D Y ++E + G G+++ + C++ T+ EYAVK+
Sbjct: 390 DGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETI-GVGSYSECKRCVHKATNMEYAVKV 448
Query: 115 IEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKR 174
I+K + E+E+L + H N++ L + +++ YLV E MRGG +L I ++
Sbjct: 449 IDKS----KRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQ 504
Query: 175 RHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENIL-CEHPNQVSPVKICDFDLGSGI 233
+ F+E EAS V+ + +++LH++G+ HRDLKP NIL + ++ICDF +
Sbjct: 505 KFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL 564
Query: 234 KLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYP 293
+ L+TPC +A ++APEV++ YD+ CD+WSLG++LY +L+GY
Sbjct: 565 RAENGL-------LMTPCYTANFVAPEVLKRQG-----YDEGCDIWSLGILLYTMLAGYT 612
Query: 294 PFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDA 353
PF + I GK+ +W +S AKDL+SK+L D
Sbjct: 613 PFANGPSD------------TPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 660
Query: 354 KQRLSAAQVLQHPWV 368
QRL+A QVLQHPWV
Sbjct: 661 HQRLTAKQVLQHPWV 675
Score = 101 bits (252), Expect = 1e-21
Identities = 70/215 (32%), Positives = 113/215 (52%), Gaps = 21/215 (9%)
Query: 89 VLGEGAHARVQTCINLITSQE----YAVKIIEKQPGHIRSRVFREVEM-LYQCQGHRNVL 143
VLG+G+ +V + +T + YA+K+++K +R RV ++E + H V+
Sbjct: 67 VLGQGSFGKV-FLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVV 125
Query: 144 ELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAH 203
+L F+ E + YL+ + +RGG + + + K F E + + ++A LD LH+ GI +
Sbjct: 126 KLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIY 185
Query: 204 RDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVE 263
RDLKPENIL + +K+ DF L S ++ + S CG+ EYMAPEVV
Sbjct: 186 RDLKPENILLDEEGH---IKLTDFGL-SKEAIDHEKKAYSF------CGTVEYMAPEVVN 235
Query: 264 AFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGR 298
S D WS GV+++ +L+G PF G+
Sbjct: 236 RQGHSHS-----ADWWSYGVLMFEMLTGSLPFQGK 265
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 182 bits (462), Expect = 6e-46
Identities = 106/307 (34%), Positives = 167/307 (54%), Gaps = 25/307 (8%)
Query: 85 LQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLE 144
L++ LGEG+ + + C++ ++Q +AVKII K+ + + +E+ L C+GH N+++
Sbjct: 427 LKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKR---MEANTQKEITALKLCEGHPNIVK 483
Query: 145 LIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHR 204
L E F ++ +LV E + GG + I K++HF+E EAS +++ + SA+ +H+ G+ HR
Sbjct: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
Query: 205 DLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEA 264
DLKPEN+L N +KI DF P L TPC + Y APE++
Sbjct: 544 DLKPENLLFTDENDNLEIKIIDFGFAR-------LKPPDNQPLKTPCFTLHYAAPELL-- 594
Query: 265 FSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQE 324
+ YD+ CDLWSLGVILY +LSG PF DR C + ++ + I++
Sbjct: 595 ---NQNGYDESCDLWSLGVILYTMLSGQVPFQSH-------DRSLTCTSAVEIM-KKIKK 643
Query: 325 GKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCA--PENTLPTPMV 382
G + F + W ++S AKDLI LL D +RL + + + W+Q + N L TP +
Sbjct: 644 GDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDI 703
Query: 383 LQRNSCA 389
L + A
Sbjct: 704 LGSSGAA 710
Score = 110 bits (275), Expect = 3e-24
Identities = 87/295 (29%), Positives = 141/295 (47%), Gaps = 43/295 (14%)
Query: 89 VLGEGAHARVQTCINLI---TSQEYAVKIIEK----QPGHIRSRVFREVEMLYQCQGHRN 141
VLG GA+ +V + T + YA+K+++K Q E ++L +
Sbjct: 54 VLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPF 113
Query: 142 VLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGI 201
++ L F+ E + +L+ + + GG + +H+ +R F E E + V ++ AL+ LH GI
Sbjct: 114 LVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGI 173
Query: 202 AHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEV 261
+RD+K ENIL + V + DF L + T + CG+ EYMAP++
Sbjct: 174 IYRDIKLENILLDSNGH---VVLTDFGLSKEFVAD------ETERAYSFCGTIEYMAPDI 224
Query: 262 VEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFV--GRCGSDCGWDRGEACPACQNMLF 319
V S +DK D WSLGV++Y LL+G PF G S Q +
Sbjct: 225 VRGGD---SGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNS-------------QAEIS 268
Query: 320 ESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRL-----SAAQVLQHPWVQ 369
I + + +P + +S AKDLI +LL++D K+RL A ++ +H + Q
Sbjct: 269 RRILKSEPPYPQE----MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQ 319
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 182 bits (462), Expect = 6e-46
Identities = 119/331 (35%), Positives = 177/331 (53%), Gaps = 26/331 (7%)
Query: 63 GKKKKRGRATDSFSGRFEDV-YQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGH 121
G + GRA + S + L+E LG+G+ + + C + QE+AVKI+ ++
Sbjct: 383 GAGDRPGRAAVARSAMMQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRR--- 439
Query: 122 IRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELE 181
+ + REV L CQ H NV+ L E ++ YLV E +RGG +L HI K+RHF+E E
Sbjct: 440 LEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESE 499
Query: 182 ASVVVQDVASALDFLHNK-GIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS 240
AS +++ + SA+ F+H + G+ HRDLKPENIL +PVKI DF +L
Sbjct: 500 ASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFA---RLRPQSP 556
Query: 241 PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG 300
+ + TPC + +Y APE++ YD+ CDLWSLGVILY++LSG PF G G
Sbjct: 557 GV---PMQTPCFTLQYAAPELLAQQG-----YDESCDLWSLGVILYMMLSGQVPFQGASG 608
Query: 301 SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA 360
+G A + M I+EG++ + W +S AK+L+ LL D +RL
Sbjct: 609 ------QGGQSQAAEIMC--KIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLE 660
Query: 361 QVLQHPWVQGCAPENTLP--TPMVLQRNSCA 389
+ W+Q + ++ P TP VL+ + A
Sbjct: 661 GLRGSSWLQDGSARSSPPLRTPDVLESSGPA 691
Score = 103 bits (256), Expect = 4e-22
Identities = 90/332 (27%), Positives = 150/332 (45%), Gaps = 57/332 (17%)
Query: 89 VLGEGAHARV---QTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLEL 145
VLG GA+ +V + + YA+K++ K + + + + + R+VLEL
Sbjct: 38 VLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRK------AALVQRAKTQEHTRTERSVLEL 91
Query: 146 IE----------FFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDF 195
+ F+ + + +L+ + + GG + +H+++R++F E E V ++ AL+
Sbjct: 92 VRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEH 151
Query: 196 LHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAE 255
LH GI +RDLK EN+L + + + DF L + CG+ E
Sbjct: 152 LHKLGIIYRDLKLENVLLDSEGH---IVLTDFGLSKEFLTE------EKERTFSFCGTIE 202
Query: 256 YMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQ 315
YMAPE++ + + + K D WSLG++L+ LL+G PF E Q
Sbjct: 203 YMAPEIIRS----KTGHGKAVDWWSLGILLFELLTGASPFT-----------LEGERNTQ 247
Query: 316 NMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA-----QVLQHPWVQG 370
+ I + FP + I A+DL+ +LL +D K+RL A +V HP+ QG
Sbjct: 248 AEVSRRILKCSPPFPPR----IGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQG 303
Query: 371 ----CAPENTLPTPMVLQRNSCAKDLTSFAAE 398
+P P Q S D+ +FA E
Sbjct: 304 LDWVALAARKIPAPFRPQIRS-ELDVGNFAEE 334
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 182 bits (461), Expect = 7e-46
Identities = 120/337 (35%), Positives = 178/337 (52%), Gaps = 32/337 (9%)
Query: 63 GKKKKRGRATDSFSGRFEDV-------YQLQEDVLGEGAHARVQTCINLITSQEYAVKII 115
G + GRA + S +D L+E LG+G+ + + C + QE+AVKI+
Sbjct: 383 GAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKIL 442
Query: 116 EKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRR 175
++ + + REV L CQ H NV+ L E ++ YLV E +RGG +L HI K+R
Sbjct: 443 SRR---LEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKR 499
Query: 176 HFNELEASVVVQDVASALDFLHNK-GIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIK 234
HF+E EAS +++ + SA+ F+H + G+ HRDLKPENIL +PVKI DF +
Sbjct: 500 HFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFA---R 556
Query: 235 LNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPP 294
L + + TPC + +Y APE++ YD+ CDLWSLGVILY++LSG P
Sbjct: 557 LRPQSPGV---PMQTPCFTLQYAAPELLAQQG-----YDESCDLWSLGVILYMMLSGQVP 608
Query: 295 FVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAK 354
F G G +G A + M I+EG++ + W +S AK+L+ LL D
Sbjct: 609 FQGASG------QGGQSQAAEIMC--KIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA 660
Query: 355 QRLSAAQVLQHPWVQGCAPENTLP--TPMVLQRNSCA 389
+RL + W+Q + ++ P TP VL+ + A
Sbjct: 661 KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPA 697
Score = 103 bits (256), Expect = 4e-22
Identities = 90/332 (27%), Positives = 150/332 (45%), Gaps = 57/332 (17%)
Query: 89 VLGEGAHARV---QTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLEL 145
VLG GA+ +V + + YA+K++ K + + + + + R+VLEL
Sbjct: 38 VLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRK------AALVQRAKTQEHTRTERSVLEL 91
Query: 146 IE----------FFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDF 195
+ F+ + + +L+ + + GG + +H+++R++F E E V ++ AL+
Sbjct: 92 VRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEH 151
Query: 196 LHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAE 255
LH GI +RDLK EN+L + + + DF L + CG+ E
Sbjct: 152 LHKLGIIYRDLKLENVLLDSEGH---IVLTDFGLSKEFLTE------EKERTFSFCGTIE 202
Query: 256 YMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQ 315
YMAPE++ + + + K D WSLG++L+ LL+G PF E Q
Sbjct: 203 YMAPEIIRS----KTGHGKAVDWWSLGILLFELLTGASPFT-----------LEGERNTQ 247
Query: 316 NMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA-----QVLQHPWVQG 370
+ I + FP + I A+DL+ +LL +D K+RL A +V HP+ QG
Sbjct: 248 AEVSRRILKCSPPFPPR----IGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQG 303
Query: 371 ----CAPENTLPTPMVLQRNSCAKDLTSFAAE 398
+P P Q S D+ +FA E
Sbjct: 304 LDWVALAARKIPAPFRPQIRS-ELDVGNFAEE 334
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 181 bits (459), Expect = 1e-45
Identities = 105/292 (35%), Positives = 165/292 (56%), Gaps = 30/292 (10%)
Query: 78 RFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQ 137
+F D Y+++ED+ G G+++ + CI+ T+ E+AVKII+K + E+E+L +
Sbjct: 417 QFTDGYEVKEDI-GVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPTEEIEILLRYG 471
Query: 138 GHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLH 197
H N++ L + +++ Y+V E M+GG +L I +++ F+E EAS V+ + +++LH
Sbjct: 472 QHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLH 531
Query: 198 NKGIAHRDLKPENIL-CEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEY 256
+G+ HRDLKP NIL + ++ICDF ++ L+TPC +A +
Sbjct: 532 AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGL-------LMTPCYTANF 584
Query: 257 MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQN 316
+APEV++ YD CD+WSLGV+LY +L+GY PF G D D E
Sbjct: 585 VAPEVLKRQG-----YDAACDIWSLGVLLYTMLTGYTPFAN--GPD---DTPEE------ 628
Query: 317 MLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 368
+ I GK+ W +S AKDL+SK+L D QRL+AA VL+HPW+
Sbjct: 629 -ILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
Score = 105 bits (261), Expect = 1e-22
Identities = 84/275 (30%), Positives = 130/275 (47%), Gaps = 38/275 (13%)
Query: 89 VLGEGAHARVQTCINLITS---QEYAVKIIEKQPGHIRSRVFREVEMLYQCQ-GHRNVLE 144
VLG+G+ +V + S Q YA+K+++K +R RV ++E + H +++
Sbjct: 73 VLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVK 132
Query: 145 LIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHR 204
L F+ E + YL+ + +RGG + + + K F E + + ++A ALD LH+ GI +R
Sbjct: 133 LHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYR 192
Query: 205 DLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEA 264
DLKPENIL + +K+ DF L S + + CG+ EYMAPEVV
Sbjct: 193 DLKPENILLDEEGH---IKLTDFGLSKE-------SIDHEKKAYSFCGTVEYMAPEVVNR 242
Query: 265 FSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQE 324
S D WS GV+++ +L+G PF G+ DR E I +
Sbjct: 243 RGHTQS-----ADWWSFGVLMFEMLTGTLPFQGK-------DRKET--------MTMILK 282
Query: 325 GKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSA 359
K P +S A+ L+ L R+ RL A
Sbjct: 283 AKLGMPQ----FLSPEAQSLLRMLFKRNPANRLGA 313
>gi|21237768 MAP kinase-activated protein kinase 5 isoform 2 [Homo
sapiens]
Length = 473
Score = 180 bits (456), Expect = 3e-45
Identities = 113/339 (33%), Positives = 171/339 (50%), Gaps = 49/339 (14%)
Query: 90 LGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFF 149
LG G V+ C+ T + +A+KI+ +P + EV + C H N++++IE F
Sbjct: 28 LGAGISGPVRVCVKKSTQERFALKILLDRP-----KARNEVRLHMMCATHPNIVQIIEVF 82
Query: 150 EEEDRF----------YLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNK 199
+F +V E M GG + I + RHF E +AS V + +A AL H
Sbjct: 83 ANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLL 142
Query: 200 GIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAP 259
IAHRDLKPEN+L + + +PVK+CDF + I +L+TP + Y+AP
Sbjct: 143 NIAHRDLKPENLLFKDNSLDAPVKLCDFGF----------AKIDQGDLMTPQFTPYYVAP 192
Query: 260 EVVEA----FSEEASI---------YDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWD 306
+V+EA E++ I Y+K CDLWSLGVI+Y++L GYPPF + S
Sbjct: 193 QVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHS----- 247
Query: 307 RGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHP 366
+ I G +EFP+++W+ IS AKD++ KLL ++RL+ VL HP
Sbjct: 248 -----RTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHP 302
Query: 367 WVQGC-APENTLPTPMVLQRNSCAKDLTSFAAEAIAMNR 404
W+ A +N LP+ ++ + + AE +A R
Sbjct: 303 WLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMR 341
>gi|21237765 MAP kinase-activated protein kinase 5 isoform 1 [Homo
sapiens]
Length = 471
Score = 180 bits (456), Expect = 3e-45
Identities = 113/339 (33%), Positives = 171/339 (50%), Gaps = 49/339 (14%)
Query: 90 LGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFF 149
LG G V+ C+ T + +A+KI+ +P + EV + C H N++++IE F
Sbjct: 28 LGAGISGPVRVCVKKSTQERFALKILLDRP-----KARNEVRLHMMCATHPNIVQIIEVF 82
Query: 150 EEEDRF----------YLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNK 199
+F +V E M GG + I + RHF E +AS V + +A AL H
Sbjct: 83 ANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLL 142
Query: 200 GIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAP 259
IAHRDLKPEN+L + + +PVK+CDF + I +L+TP + Y+AP
Sbjct: 143 NIAHRDLKPENLLFKDNSLDAPVKLCDFGF----------AKIDQGDLMTPQFTPYYVAP 192
Query: 260 EVVEA----FSEEASI---------YDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWD 306
+V+EA E++ I Y+K CDLWSLGVI+Y++L GYPPF + S
Sbjct: 193 QVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHS----- 247
Query: 307 RGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHP 366
+ I G +EFP+++W+ IS AKD++ KLL ++RL+ VL HP
Sbjct: 248 -----RTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHP 302
Query: 367 WVQGC-APENTLPTPMVLQRNSCAKDLTSFAAEAIAMNR 404
W+ A +N LP+ ++ + + AE +A R
Sbjct: 303 WLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMR 341
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 179 bits (454), Expect = 5e-45
Identities = 107/283 (37%), Positives = 152/283 (53%), Gaps = 30/283 (10%)
Query: 88 DVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIE 147
+VLG GA + V +T + +A+K I+K P S + E+ +L + + H N++ L +
Sbjct: 27 EVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIK-HENIVTLED 85
Query: 148 FFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLK 207
+E +YLV + + GG + I +R + E +AS+V+Q V SA+ +LH GI HRDLK
Sbjct: 86 IYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLK 145
Query: 208 PENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSE 267
PEN+L P + S + I DF L S ++ NG S T CG+ Y+APEV+
Sbjct: 146 PENLLYLTPEENSKIMITDFGL-SKMEQNGIMS--------TACGTPGYVAPEVL----- 191
Query: 268 EASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKY 327
Y K D WS+GVI YILL GYPPF ++ LFE I+EG Y
Sbjct: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFY---------------EETESKLFEKIKEGYY 236
Query: 328 EFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQG 370
EF W IS +AKD I LL +D +R + + L HPW+ G
Sbjct: 237 EFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDG 279
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 178 bits (451), Expect = 1e-44
Identities = 116/344 (33%), Positives = 182/344 (52%), Gaps = 34/344 (9%)
Query: 39 GLQCSARPDMPAS---QPIDIPDAKKRGKKK-KRGRATDSFSGRFEDVYQLQEDVLGEGA 94
G + + R D PA +P P+ K + ++ R + E Y+ V+G+G
Sbjct: 308 GRRMTLRDDQPAKLEKEPKTRPEENKPERPSGRKPRPMGIIAANVEKHYETGR-VIGDGN 366
Query: 95 HARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDR 154
A V+ C + T Q YA+KII+K + + ++ Q H N+++L E +E +
Sbjct: 367 FAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIVKLHEVYETDME 426
Query: 155 FYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCE 214
YL+ E ++GG + I + F E +A++++ D+ AL +H+K I HRDLKPEN+L +
Sbjct: 427 IYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQ 486
Query: 215 -HPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYD 273
+ ++ + +K+ DF L + + T CG+ Y+APE++ SE+ Y
Sbjct: 487 RNEDKSTTLKLADFGLAKHV----------VRPIFTVCGTPTYVAPEIL---SEKG--YG 531
Query: 274 KRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKD 333
D+W+ GVILYILL G+PPF + Q+ LF IQ G +EF
Sbjct: 532 LEVDMWAAGVILYILLCGFPPF-------------RSPERDQDELFNIIQLGHFEFLPPY 578
Query: 334 WAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTL 377
W +IS AAKDL+S+LLV D K+R +A QVLQHPW++ NT+
Sbjct: 579 WDNISDAAKDLVSRLLVVDPKKRYTAHQVLQHPWIETAGKTNTV 622
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 177 bits (448), Expect = 2e-44
Identities = 104/294 (35%), Positives = 164/294 (55%), Gaps = 30/294 (10%)
Query: 76 SGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQ 135
+ +F +VY+L+ED+ G G+++ + CI+ T+ E+AVKII+K + E+E+L +
Sbjct: 419 AAQFGEVYELKEDI-GVGSYSVCKRCIHATTNMEFAVKIIDKS----KRDPSEEIEILMR 473
Query: 136 CQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDF 195
H N++ L + F++ YLV + M+GG +L I K++ F+E EAS ++ ++ +D+
Sbjct: 474 YGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDY 533
Query: 196 LHNKGIAHRDLKPENIL-CEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSA 254
LH +G+ HRDLKP NIL + ++ICDF G +L G+ LLTPC +A
Sbjct: 534 LHCQGVVHRDLKPSNILYMDESASADSIRICDF--GFAKQLRGE-----NGLLLTPCYTA 586
Query: 255 EYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPAC 314
++APEV+ YD CD+WSLGV+ Y +L+GY PF
Sbjct: 587 NFVAPEVLMQQG-----YDAACDIWSLGVLFYTMLAGYTPFANGPND------------T 629
Query: 315 QNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 368
+ I GK+ +W +IS AKDL+S +L D QR +A Q+L+H W+
Sbjct: 630 PEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWI 683
Score = 108 bits (269), Expect = 1e-23
Identities = 84/278 (30%), Positives = 134/278 (48%), Gaps = 38/278 (13%)
Query: 89 VLGEGAHARV---QTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQ-GHRNVLE 144
VLG+G+ +V + Q YA+K+++K +R RV ++E + H +++
Sbjct: 78 VLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVK 137
Query: 145 LIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHR 204
L F+ E + YL+ + +RGG + + + K F E + + ++A ALD LH GI +R
Sbjct: 138 LHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYR 197
Query: 205 DLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEA 264
DLKPENIL + ++ +K+ DF L S + + CG+ EYMAPEVV
Sbjct: 198 DLKPENILLD---EIGHIKLTDFGLSKE-------SVDQEKKAYSFCGTVEYMAPEVVNR 247
Query: 265 FSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQE 324
S D WS GV+++ +L+G PF G+ DR E NM+ ++
Sbjct: 248 RGHSQS-----ADWWSYGVLMFEMLTGTLPFQGK-------DRNET----MNMILKA--- 288
Query: 325 GKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQV 362
K P +S A+ L+ L R+ RL + V
Sbjct: 289 -KLGMPQ----FLSAEAQSLLRMLFKRNPANRLGSEGV 321
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 176 bits (447), Expect = 3e-44
Identities = 106/292 (36%), Positives = 161/292 (55%), Gaps = 29/292 (9%)
Query: 78 RFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEM-LYQC 136
RF D YQL E+ LG+GA + V+ C+ + T QEYA KII + R E E + +
Sbjct: 9 RFTDEYQLFEE-LGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 137 QGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFL 196
H N++ L + EE YLVF+ + GG + I R +++E +AS +Q + +++
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 197 HNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEY 256
H GI HRDLKPEN+L ++ + VK+ DF G I++ GD G+ Y
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADF--GLAIEVQGD-----QQAWFGFAGTPGY 180
Query: 257 MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQN 316
++PEV+ Y K D+W+ GVILYILL GYPPF WD Q+
Sbjct: 181 LSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------QH 220
Query: 317 MLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 368
L++ I+ G Y+FP +W ++ AKDLI+K+L + +R++A++ L+HPW+
Sbjct: 221 RLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 176 bits (447), Expect = 3e-44
Identities = 106/292 (36%), Positives = 161/292 (55%), Gaps = 29/292 (9%)
Query: 78 RFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEM-LYQC 136
RF D YQL E+ LG+GA + V+ C+ + T QEYA KII + R E E + +
Sbjct: 9 RFTDEYQLFEE-LGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 137 QGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFL 196
H N++ L + EE YLVF+ + GG + I R +++E +AS +Q + +++
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 197 HNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEY 256
H GI HRDLKPEN+L ++ + VK+ DF G I++ GD G+ Y
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADF--GLAIEVQGD-----QQAWFGFAGTPGY 180
Query: 257 MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQN 316
++PEV+ Y K D+W+ GVILYILL GYPPF WD Q+
Sbjct: 181 LSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------QH 220
Query: 317 MLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 368
L++ I+ G Y+FP +W ++ AKDLI+K+L + +R++A++ L+HPW+
Sbjct: 221 RLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 176 bits (447), Expect = 3e-44
Identities = 106/292 (36%), Positives = 161/292 (55%), Gaps = 29/292 (9%)
Query: 78 RFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEM-LYQC 136
RF D YQL E+ LG+GA + V+ C+ + T QEYA KII + R E E + +
Sbjct: 9 RFTDEYQLFEE-LGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 137 QGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFL 196
H N++ L + EE YLVF+ + GG + I R +++E +AS +Q + +++
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 197 HNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEY 256
H GI HRDLKPEN+L ++ + VK+ DF G I++ GD G+ Y
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADF--GLAIEVQGD-----QQAWFGFAGTPGY 180
Query: 257 MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQN 316
++PEV+ Y K D+W+ GVILYILL GYPPF WD Q+
Sbjct: 181 LSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------QH 220
Query: 317 MLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 368
L++ I+ G Y+FP +W ++ AKDLI+K+L + +R++A++ L+HPW+
Sbjct: 221 RLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 176 bits (447), Expect = 3e-44
Identities = 106/292 (36%), Positives = 161/292 (55%), Gaps = 29/292 (9%)
Query: 78 RFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEM-LYQC 136
RF D YQL E+ LG+GA + V+ C+ + T QEYA KII + R E E + +
Sbjct: 9 RFTDEYQLFEE-LGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 137 QGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFL 196
H N++ L + EE YLVF+ + GG + I R +++E +AS +Q + +++
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 197 HNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEY 256
H GI HRDLKPEN+L ++ + VK+ DF G I++ GD G+ Y
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADF--GLAIEVQGD-----QQAWFGFAGTPGY 180
Query: 257 MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQN 316
++PEV+ Y K D+W+ GVILYILL GYPPF WD Q+
Sbjct: 181 LSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------QH 220
Query: 317 MLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 368
L++ I+ G Y+FP +W ++ AKDLI+K+L + +R++A++ L+HPW+
Sbjct: 221 RLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 176 bits (447), Expect = 3e-44
Identities = 106/292 (36%), Positives = 161/292 (55%), Gaps = 29/292 (9%)
Query: 78 RFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEM-LYQC 136
RF D YQL E+ LG+GA + V+ C+ + T QEYA KII + R E E + +
Sbjct: 9 RFTDEYQLFEE-LGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 137 QGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFL 196
H N++ L + EE YLVF+ + GG + I R +++E +AS +Q + +++
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 197 HNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEY 256
H GI HRDLKPEN+L ++ + VK+ DF G I++ GD G+ Y
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADF--GLAIEVQGD-----QQAWFGFAGTPGY 180
Query: 257 MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQN 316
++PEV+ Y K D+W+ GVILYILL GYPPF WD Q+
Sbjct: 181 LSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------QH 220
Query: 317 MLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 368
L++ I+ G Y+FP +W ++ AKDLI+K+L + +R++A++ L+HPW+
Sbjct: 221 RLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 176 bits (447), Expect = 3e-44
Identities = 106/292 (36%), Positives = 161/292 (55%), Gaps = 29/292 (9%)
Query: 78 RFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEM-LYQC 136
RF D YQL E+ LG+GA + V+ C+ + T QEYA KII + R E E + +
Sbjct: 9 RFTDEYQLFEE-LGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 137 QGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFL 196
H N++ L + EE YLVF+ + GG + I R +++E +AS +Q + +++
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 197 HNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEY 256
H GI HRDLKPEN+L ++ + VK+ DF G I++ GD G+ Y
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADF--GLAIEVQGD-----QQAWFGFAGTPGY 180
Query: 257 MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQN 316
++PEV+ Y K D+W+ GVILYILL GYPPF WD Q+
Sbjct: 181 LSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------QH 220
Query: 317 MLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 368
L++ I+ G Y+FP +W ++ AKDLI+K+L + +R++A++ L+HPW+
Sbjct: 221 RLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 176 bits (446), Expect = 4e-44
Identities = 116/342 (33%), Positives = 168/342 (49%), Gaps = 33/342 (9%)
Query: 36 SDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAH 95
S + C P ++P P + R K + F R Y ++ ++G G+
Sbjct: 56 SQYAHPCPGPPTAGHTEPPSEPPRRARVAKYRA-----KFDPRVTAKYDIKA-LIGRGSF 109
Query: 96 ARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRF 155
+RV + T Q YA+K+IE + R E+ +L + + H N+++L+E FE ++R
Sbjct: 110 SRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVR-HANIIQLVEVFETQERV 168
Query: 156 YLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEH 215
Y+V E GG + I + F E +A+ V+Q V + +LH GI HRDLKPEN+L H
Sbjct: 169 YMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYH 228
Query: 216 PNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKR 275
P S + I DF L S K DC + T CG+ EY+APEV+ Y
Sbjct: 229 PGTDSKIIITDFGLASARKKGDDCL------MKTTCGTPEYIAPEVL-----VRKPYTNS 277
Query: 276 CDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWA 335
D+W+LGVI YILLSG PF D R L+ I GKY + + W
Sbjct: 278 VDMWALGVIAYILLSGTMPF-----EDDNRTR----------LYRQILRGKYSYSGEPWP 322
Query: 336 HISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTL 377
+S AKD I +LL D R++A Q L+HPWV A +++
Sbjct: 323 SVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSM 364
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 175 bits (443), Expect = 9e-44
Identities = 104/292 (35%), Positives = 159/292 (54%), Gaps = 29/292 (9%)
Query: 78 RFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEM-LYQC 136
RF + YQL E+ LG+GA + V+ C+ ++ QEYA KII + R E E + +
Sbjct: 8 RFTEEYQLFEE-LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRL 66
Query: 137 QGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFL 196
H N++ L + EE YL+F+ + GG + I R +++E +AS +Q + A+
Sbjct: 67 LKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 126
Query: 197 HNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEY 256
H G+ HRDLKPEN+L + + VK+ DF G I++ G+ G+ Y
Sbjct: 127 HQMGVVHRDLKPENLLLASKLKGAAVKLADF--GLAIEVEGE-----QQAWFGFAGTPGY 179
Query: 257 MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQN 316
++PEV+ Y K DLW+ GVILYILL GYPPF WD Q+
Sbjct: 180 LSPEVL-----RKDPYGKPVDLWACGVILYILLVGYPPF---------WDED------QH 219
Query: 317 MLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 368
L++ I+ G Y+FP +W ++ AKDLI+K+L + +R++AA+ L+HPW+
Sbjct: 220 RLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 271
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 175 bits (443), Expect = 9e-44
Identities = 104/292 (35%), Positives = 159/292 (54%), Gaps = 29/292 (9%)
Query: 78 RFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEM-LYQC 136
RF + YQL E+ LG+GA + V+ C+ ++ QEYA KII + R E E + +
Sbjct: 8 RFTEEYQLFEE-LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRL 66
Query: 137 QGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFL 196
H N++ L + EE YL+F+ + GG + I R +++E +AS +Q + A+
Sbjct: 67 LKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 126
Query: 197 HNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEY 256
H G+ HRDLKPEN+L + + VK+ DF G I++ G+ G+ Y
Sbjct: 127 HQMGVVHRDLKPENLLLASKLKGAAVKLADF--GLAIEVEGE-----QQAWFGFAGTPGY 179
Query: 257 MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQN 316
++PEV+ Y K DLW+ GVILYILL GYPPF WD Q+
Sbjct: 180 LSPEVL-----RKDPYGKPVDLWACGVILYILLVGYPPF---------WDED------QH 219
Query: 317 MLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 368
L++ I+ G Y+FP +W ++ AKDLI+K+L + +R++AA+ L+HPW+
Sbjct: 220 RLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 271
>gi|26051204 calcium/calmodulin-dependent protein kinase II beta
isoform 1 [Homo sapiens]
Length = 666
Score = 174 bits (442), Expect = 1e-43
Identities = 109/299 (36%), Positives = 162/299 (54%), Gaps = 29/299 (9%)
Query: 71 ATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREV 130
AT RF D YQL ED+ G+GA + V+ C+ L T EYA KII + R E
Sbjct: 2 ATTVTCTRFTDEYQLYEDI-GKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLER 60
Query: 131 EM-LYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDV 189
E + + H N++ L + EE YLVF+ + GG + I R +++E +AS +Q +
Sbjct: 61 EARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI 120
Query: 190 ASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLT 249
A+ H G+ HRDLKPEN+L + + VK+ DF G I++ GD
Sbjct: 121 LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADF--GLAIEVQGD-----QQAWFG 173
Query: 250 PCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGE 309
G+ Y++PEV+ +EA Y K D+W+ GVILYILL GYPPF WD
Sbjct: 174 FAGTPGYLSPEVLR---KEA--YGKPVDIWACGVILYILLVGYPPF---------WDED- 218
Query: 310 ACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 368
Q+ L++ I+ G Y+FP +W ++ AK+LI+++L + +R++A + L+HPWV
Sbjct: 219 -----QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV 272
>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
isoform 4 [Homo sapiens]
Length = 517
Score = 174 bits (442), Expect = 1e-43
Identities = 109/299 (36%), Positives = 162/299 (54%), Gaps = 29/299 (9%)
Query: 71 ATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREV 130
AT RF D YQL ED+ G+GA + V+ C+ L T EYA KII + R E
Sbjct: 2 ATTVTCTRFTDEYQLYEDI-GKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLER 60
Query: 131 EM-LYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDV 189
E + + H N++ L + EE YLVF+ + GG + I R +++E +AS +Q +
Sbjct: 61 EARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI 120
Query: 190 ASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLT 249
A+ H G+ HRDLKPEN+L + + VK+ DF G I++ GD
Sbjct: 121 LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADF--GLAIEVQGD-----QQAWFG 173
Query: 250 PCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGE 309
G+ Y++PEV+ +EA Y K D+W+ GVILYILL GYPPF WD
Sbjct: 174 FAGTPGYLSPEVLR---KEA--YGKPVDIWACGVILYILLVGYPPF---------WDED- 218
Query: 310 ACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 368
Q+ L++ I+ G Y+FP +W ++ AK+LI+++L + +R++A + L+HPWV
Sbjct: 219 -----QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV 272
>gi|26051214 calcium/calmodulin-dependent protein kinase II beta
isoform 6 [Homo sapiens]
Length = 492
Score = 174 bits (442), Expect = 1e-43
Identities = 109/299 (36%), Positives = 162/299 (54%), Gaps = 29/299 (9%)
Query: 71 ATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREV 130
AT RF D YQL ED+ G+GA + V+ C+ L T EYA KII + R E
Sbjct: 2 ATTVTCTRFTDEYQLYEDI-GKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLER 60
Query: 131 EM-LYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDV 189
E + + H N++ L + EE YLVF+ + GG + I R +++E +AS +Q +
Sbjct: 61 EARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI 120
Query: 190 ASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLT 249
A+ H G+ HRDLKPEN+L + + VK+ DF G I++ GD
Sbjct: 121 LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADF--GLAIEVQGD-----QQAWFG 173
Query: 250 PCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGE 309
G+ Y++PEV+ +EA Y K D+W+ GVILYILL GYPPF WD
Sbjct: 174 FAGTPGYLSPEVLR---KEA--YGKPVDIWACGVILYILLVGYPPF---------WDED- 218
Query: 310 ACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 368
Q+ L++ I+ G Y+FP +W ++ AK+LI+++L + +R++A + L+HPWV
Sbjct: 219 -----QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV 272
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,960,484
Number of Sequences: 37866
Number of extensions: 876819
Number of successful extensions: 4692
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 527
Number of HSP's successfully gapped in prelim test: 252
Number of HSP's that attempted gapping in prelim test: 2605
Number of HSP's gapped (non-prelim): 969
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.