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Search of human proteins with 39979626
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|39979626 coiled-coil domain containing 121 isoform 3 [Homo
sapiens]
(278 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218083720 coiled-coil domain containing 121 isoform 2 [Homo s... 537 e-153
gi|218083716 coiled-coil domain containing 121 isoform 1 [Homo s... 537 e-153
gi|39979626 coiled-coil domain containing 121 isoform 3 [Homo sa... 537 e-153
gi|242332545 coiled-coil domain containing 121-like [Homo sapiens] 69 3e-12
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 64 1e-10
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 60 2e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 60 2e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 60 2e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 60 2e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 60 2e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 60 2e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 60 2e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 60 2e-09
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 60 2e-09
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 60 2e-09
gi|148746195 trichohyalin [Homo sapiens] 59 4e-09
gi|16262452 cingulin [Homo sapiens] 58 8e-09
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 57 1e-08
gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo s... 57 2e-08
gi|221139761 zinc finger protein 853 [Homo sapiens] 57 2e-08
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 56 3e-08
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 55 5e-08
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 55 5e-08
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 55 5e-08
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 55 5e-08
gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens] 55 5e-08
gi|134152708 arginine and glutamate rich 1 [Homo sapiens] 55 5e-08
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 55 7e-08
gi|50083279 centrosome protein 4 [Homo sapiens] 55 7e-08
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 55 7e-08
>gi|218083720 coiled-coil domain containing 121 isoform 2 [Homo
sapiens]
Length = 440
Score = 537 bits (1384), Expect = e-153
Identities = 278/278 (100%), Positives = 278/278 (100%)
Query: 1 MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS 60
MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS
Sbjct: 163 MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS 222
Query: 61 YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE 120
YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE
Sbjct: 223 YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE 282
Query: 121 IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL 180
IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL
Sbjct: 283 IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL 342
Query: 181 KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 240
KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL
Sbjct: 343 KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 402
Query: 241 IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK 278
IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK
Sbjct: 403 IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK 440
>gi|218083716 coiled-coil domain containing 121 isoform 1 [Homo
sapiens]
Length = 442
Score = 537 bits (1384), Expect = e-153
Identities = 278/278 (100%), Positives = 278/278 (100%)
Query: 1 MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS 60
MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS
Sbjct: 165 MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS 224
Query: 61 YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE 120
YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE
Sbjct: 225 YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE 284
Query: 121 IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL 180
IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL
Sbjct: 285 IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL 344
Query: 181 KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 240
KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL
Sbjct: 345 KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 404
Query: 241 IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK 278
IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK
Sbjct: 405 IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK 442
>gi|39979626 coiled-coil domain containing 121 isoform 3 [Homo
sapiens]
Length = 278
Score = 537 bits (1384), Expect = e-153
Identities = 278/278 (100%), Positives = 278/278 (100%)
Query: 1 MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS 60
MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS
Sbjct: 1 MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS 60
Query: 61 YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE 120
YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE
Sbjct: 61 YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE 120
Query: 121 IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL 180
IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL
Sbjct: 121 IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL 180
Query: 181 KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 240
KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL
Sbjct: 181 KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 240
Query: 241 IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK 278
IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK
Sbjct: 241 IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK 278
>gi|242332545 coiled-coil domain containing 121-like [Homo sapiens]
Length = 439
Score = 69.3 bits (168), Expect = 3e-12
Identities = 51/230 (22%), Positives = 110/230 (47%), Gaps = 12/230 (5%)
Query: 4 LNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 63
L++ + + Q+L E+ L RE L ++ ENR + Y++ + + + ++
Sbjct: 41 LSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVRLDEQNRV 100
Query: 64 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 123
+I +R E AS Y + ++ LL+ E + + +++Q ++ +L+ +Q I+
Sbjct: 101 DLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRA 160
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLA 183
L+ E ++ E V+ + L++K E++ + + L +R RE
Sbjct: 161 LERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQRVQSL-ARRAERE----------- 208
Query: 184 AKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 233
A R + ++ I +N + ++ELL L+ + Q L T+ L +++QL +E
Sbjct: 209 AVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHRE 258
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 64.3 bits (155), Expect = 1e-10
Identities = 72/262 (27%), Positives = 133/262 (50%), Gaps = 18/262 (6%)
Query: 1 MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAEN-RFFLEYLTNKTEEYTEQPEKVWN 59
M + K I Q + K L+E+ L ++K +V AE R E L K EE + ++
Sbjct: 338 MAEKTKLITQLR-DAKNLIEQ---LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRI-- 391
Query: 60 SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD--IAILKEKQ 117
+ GE R ++E + R A L+ AL + + + +RKL+A D I +++
Sbjct: 392 KQMTTQGEELREQKEKSERAA--FEELEKALSTAQKTEEA-RRKLKAEMDEQIKTIEKTS 448
Query: 118 EKEIQTLQEETKKVQAETAS-KTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK 176
E+E +LQ+E +V+ E + + Q+ + ++L EK+L+ ++ L K + RE +
Sbjct: 449 EEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQ 508
Query: 177 AQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE-QW 235
Q +K+A ++ EY I++E +Q + L+ +E +K T+S EN+ + LQQE +
Sbjct: 509 EQ-MKVALEKSQSEY-LKISQEKEQQESLALEELELQKKAILTES--ENKLRDLQQEAET 564
Query: 236 YLESLIQARQRLQGSHNQCLNR 257
Y +++ L+ S + N+
Sbjct: 565 YRTRILELESSLEKSLQENKNQ 586
Score = 48.9 bits (115), Expect = 5e-06
Identities = 59/290 (20%), Positives = 131/290 (45%), Gaps = 32/290 (11%)
Query: 1 MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAEN----RFFLEYLTNKTEEYTEQPEK 56
+ D I+Q + + ++ E++ E L ++ E R ++ +T + EE EQ EK
Sbjct: 348 LRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK 407
Query: 57 VWNSYLQK-------SGEIERRRQESASRYAEQISVL-KTALLQKENIQSSLKRKLQAMR 108
+ ++ + + E R++ + EQI + KT+ ++ ++Q L R Q +
Sbjct: 408 SERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV 467
Query: 109 DIAILK-EKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 167
D+ E+Q ++Q L E+ + + +K + + + QE+ + + S+ + + +
Sbjct: 468 DVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQ 527
Query: 168 RKRRELNMKAQALKLAAKRFIFEYS---CGINRENQQFKKELLQL---IEQAQKLTATQS 221
K ++ ++ + L+L K + E + +E + ++ +L+L +E++ + QS
Sbjct: 528 EKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQS 587
Query: 222 -----HLENRKQQ--------LQQEQWYLESLIQARQRLQGSHNQCLNRQ 258
HLE K + +++ + LESL + L Q L +Q
Sbjct: 588 KDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQ 637
Score = 47.0 bits (110), Expect = 2e-05
Identities = 58/258 (22%), Positives = 107/258 (41%), Gaps = 29/258 (11%)
Query: 10 QAQTQRKQLLEESRELHREKLLVQAENRFF------LEYLTNKTEEYTEQPEKVWNSYLQ 63
Q + + K+ E+ +++ K + +N+ F +E +K E+ E S
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTA 1525
Query: 64 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE--- 120
+ E+E + VLK QK+ L +KLQ +++ K+ + KE
Sbjct: 1526 RIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEE 1585
Query: 121 -IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQA 179
I TL+ + ++AE +K +E++ L K E + + L R E K
Sbjct: 1586 KILTLENQVYSMKAELETKKKELEHVNLSVKS------KEEELKALEDRLESESAAKLAE 1639
Query: 180 LKLAAKRFIFEYSCGINRENQQFKKELLQLIE--QAQKLTATQSHLENRKQQLQQEQWYL 237
LK A++ I KK+LL +E + Q T+SHL +LQ+ + +
Sbjct: 1640 LKRKAEQKI-----------AAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREV 1688
Query: 238 ESLIQARQRLQGSHNQCL 255
L + + ++ S ++ L
Sbjct: 1689 HILEEKLKSVESSQSETL 1706
Score = 45.1 bits (105), Expect = 7e-05
Identities = 57/282 (20%), Positives = 126/282 (44%), Gaps = 33/282 (11%)
Query: 8 IKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP-------EKVWNS 60
I Q + Q++ L E EL ++ +L ++EN+ L L + E Y + EK
Sbjct: 525 ISQEKEQQESLALEELELQKKAILTESENK--LRDLQQEAETYRTRILELESSLEKSLQE 582
Query: 61 YLQKSGEIERRRQESASRYAEQISVL----KTALLQKENIQSSL-KRKLQAMR-----DI 110
+S ++ + +++ ++I+V+ KT L ++ Q +L KLQ ++ ++
Sbjct: 583 NKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEM 642
Query: 111 AILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKR 170
L+EK E+E +TL ++ + + + E + L K+ + LS +L + R
Sbjct: 643 EKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVL--KAR 700
Query: 171 RELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQ------------KLTA 218
+L + LK + E ++ + ++++ +I++ + ++
Sbjct: 701 HKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ 760
Query: 219 TQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDV 260
+ L+ R + L++ Q ++E+L +R +G Q + DV
Sbjct: 761 LELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDV 802
Score = 43.9 bits (102), Expect = 2e-04
Identities = 56/280 (20%), Positives = 123/280 (43%), Gaps = 40/280 (14%)
Query: 1 MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLT---NKTEEYTEQPEKV 57
+ + +KH+K+ Q + L + + E A+ F Y + +T+ Y EQ ++
Sbjct: 765 LKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQL 824
Query: 58 WNSYL----------QKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 107
L ++ E+E ++++ + ++ + Q E S +++K++++
Sbjct: 825 QQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL 884
Query: 108 RDIAILK-EKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLS--EPDRRL 164
+ K E KE QE+TK++ E + +++ +E +L ++LS E +
Sbjct: 885 TQVYESKLEDGNKE----QEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI 940
Query: 165 LG----------KRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQ------ 208
L ++K ++ KA+ ++ K+ + + + +E + EL Q
Sbjct: 941 LNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFN 1000
Query: 209 --LIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQR 246
++E AQ +A S +R + Q+EQ +ESL + +R
Sbjct: 1001 AKMLEMAQANSAGISDAVSRLETNQKEQ--IESLTEVHRR 1038
Score = 38.9 bits (89), Expect = 0.005
Identities = 48/232 (20%), Positives = 110/232 (47%), Gaps = 26/232 (11%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYL 62
D+ K +++ + + L ++ +EL + + +R +E LT+K E+ Q + +
Sbjct: 1837 DVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKL--QALQQMDGRN 1894
Query: 63 QKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ 122
+ + +E +E + + Q +L Q +++ L A R+ K+K KEI
Sbjct: 1895 KPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAG---AERE----KQKLGKEIV 1947
Query: 123 TLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKL 182
LQ++ + ++ E QE +L+K+ + +R K+++ +L +K +
Sbjct: 1948 RLQKDLRMLRKEHQ-----------QELEILKKEYDQ-EREEKIKQEQEDLELKHNS--- 1992
Query: 183 AAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTA--TQSHLENRKQQLQQ 232
K+ + E++ + ++ Q+ + + + I +AQ++ A +SH E Q L++
Sbjct: 1993 TLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKK 2044
Score = 32.0 bits (71), Expect = 0.61
Identities = 46/226 (20%), Positives = 99/226 (43%), Gaps = 49/226 (21%)
Query: 62 LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQ---------------- 105
+++ + +R +E+ + EQ ++L + +KE +Q L +LQ
Sbjct: 288 VKRQENLLKRCKETIQSHKEQCTLLTS---EKEALQEQLDERLQELEKIKDLHMAEKTKL 344
Query: 106 --AMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------LQEK 150
+RD L E+ E++ + ETK+ ET E AQL L+E+
Sbjct: 345 ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQ 404
Query: 151 R---------LLEKQLSEPDRRLLGKRK-RRELNMKAQALKLAAKRFIFEYSCGINRENQ 200
+ LEK LS + +RK + E++ + + ++ ++ E + +E
Sbjct: 405 KEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSE----EERISLQQELS 460
Query: 201 QFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQR 246
+ K+E++ +++++ + + + K+ ++EQ L +Q R+R
Sbjct: 461 RVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ-ELTKKLQTRER 505
Score = 30.0 bits (66), Expect = 2.3
Identities = 61/280 (21%), Positives = 107/280 (38%), Gaps = 60/280 (21%)
Query: 7 HIKQAQTQRKQLLEESRELH--REKLLVQAENR---FFLEYLTNKTEEYTEQPEKVWNSY 61
H+ + T+ L E RE+H EKL ++ + YTEQ E
Sbjct: 1673 HLSELNTK---LQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGC 1729
Query: 62 LQKSGEIERRRQESASRYAEQISVLKTALLQK------------ENIQSSLKRKLQAMRD 109
+QK+ Y E+ISVL+ L +K E + S + + Q
Sbjct: 1730 VQKT-------------YEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQER 1776
Query: 110 IAILKEKQEKE----------IQTLQEETKKVQAETASKT-REVQAQLLQEKRLLEKQLS 158
+ L+ + K+ + L+E+ KK A +E +Q K+ LE
Sbjct: 1777 LIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFD 1836
Query: 159 EPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 218
+ + L +E + Q L+ K E + R+ + + E+ +L + +KL A
Sbjct: 1837 DVQKTL------QEKELTCQILEQKIK----ELDSCLVRQKEVHRVEMEELTSKYEKLQA 1886
Query: 219 TQS-HLENRKQQLQQEQWYLES---LIQAR--QRLQGSHN 252
Q N+ +L +E +S L+Q + ++ HN
Sbjct: 1887 LQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHN 1926
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 60.5 bits (145), Expect = 2e-09
Identities = 67/271 (24%), Positives = 122/271 (45%), Gaps = 32/271 (11%)
Query: 17 QLLEESRELHREKLL-VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIER----- 70
+LL++ +EL +E+ +Q + + L +T+ + E L+ S E ER
Sbjct: 2330 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2389
Query: 71 --------RRQESASRYAEQISVL-----KTALLQKENI---QSSLKRKLQAMRDIAILK 114
R +E A R+ +Q + +T L +E + Q+ ++ Q+ D L+
Sbjct: 2390 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2449
Query: 115 E---KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQ-LSEPDRRLLGKRKR 170
E + E+E + LQ+E K +Q ++ Q QLLQE + L++ LSE D L +R
Sbjct: 2450 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2509
Query: 171 RELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRK 227
+ K + L ++A + + E R+ QQ ++E +L+ ++ Q E
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 228 QQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 258
++ Q+E LE + ++ L NQ L Q
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQ 2597
Score = 55.5 bits (132), Expect = 5e-08
Identities = 60/269 (22%), Positives = 114/269 (42%), Gaps = 36/269 (13%)
Query: 10 QAQTQRKQLLEESRE--LHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 67
QA+ + K+L + +E + RE+ V A+ + +E +Q + + +Q
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQ------KRSIQEELQQLRQSSEAEIQAKAR 1438
Query: 68 IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE 127
+ S R E+I V++ L E + + +LQA+R A E Q+++ Q E
Sbjct: 1439 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1498
Query: 128 TKKVQAETASKTREVQAQL-----------------LQEKRLLEKQLSEPDRRLLGKRKR 170
++ + + + R+ + +L LQ L Q E +RRL
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1558
Query: 171 R--------ELNMKAQALKLAAKRFIF-EYSCGINRENQQFKKELLQLIEQAQKLTATQS 221
R E ++ +L +KR F E + + R Q+ + QL E+A++ Q+
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618
Query: 222 HLENRKQQLQQ--EQWYLESLIQARQRLQ 248
E +++ ++ E+W L++ R RLQ
Sbjct: 1619 EAERAREEAERELERWQLKANEALRLRLQ 1647
Score = 48.5 bits (114), Expect = 6e-06
Identities = 56/228 (24%), Positives = 106/228 (46%), Gaps = 25/228 (10%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+ AQ RKQ E +LHR +L Q E ++ L + ++ E++ + + E
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 69 ERRRQES---ASRYAEQISVLKTALLQKENI--QSSLKRKLQAMRDIAILKEKQEKEIQT 123
E+ +QE+ + E +V + LLQ+ QS L K ++ +++++ K Q
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRRELNMKAQA 179
Q+E K Q + R+ Q Q+ QE++ L + E RR G R+++E + +
Sbjct: 2520 FQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578
Query: 180 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ-------AQKLTATQ 220
+ + + E ENQ+ +++L L EQ ++++TA+Q
Sbjct: 2579 QRRQQEELLAE-------ENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Score = 46.6 bits (109), Expect = 2e-05
Identities = 58/244 (23%), Positives = 107/244 (43%), Gaps = 29/244 (11%)
Query: 8 IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEYLTNKTEEYT---EQPEKVWNSY 61
++ QR+Q+ EE L EK +AE L + + E+ EQ E
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 62 LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE- 120
Q + E ERRR+E+ R + ++ + A Q++ ++R + + L+E+ E+E
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032
Query: 121 ---IQTLQEET-KKVQAE-------TASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 169
+Q QE K++QAE K +E+Q L QE+ +L++ E + +
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092
Query: 170 RRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQ 229
E ++A+ ++R + E ++ K+ EQAQ Q+ E +++
Sbjct: 2093 AEEARVQAEREAAQSRRQV--------EEAERLKQ---SAEEQAQARAQAQAAAEKLRKE 2141
Query: 230 LQQE 233
+QE
Sbjct: 2142 AEQE 2145
Score = 44.3 bits (103), Expect = 1e-04
Identities = 50/247 (20%), Positives = 114/247 (46%), Gaps = 19/247 (7%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYL 62
+ + ++QA+ +R + ++ + E + +AE + KT + ++ +
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSLQEEHVAVA 1604
Query: 63 QKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ 122
Q E ERR Q+ A + + + +L+ +LQA ++A Q+K +
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA-----QQKSLA 1658
Query: 123 TLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALK 181
+ E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L + + ++
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIR 1717
Query: 182 LAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLI 241
L A+ E ++ Q ++EL +L +A T + LE +++ E +E L+
Sbjct: 1718 LRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE---MEVLL 1768
Query: 242 QARQRLQ 248
++ R +
Sbjct: 1769 ASKARAE 1775
Score = 41.6 bits (96), Expect = 8e-04
Identities = 47/238 (19%), Positives = 99/238 (41%), Gaps = 8/238 (3%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHR-----EKLLVQAENRFFLEYL-TNKTEEYTEQPEK 56
+L + ++Q Q+ QL E+ R E+ VQAE + E + E+
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 57 VWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEK 116
+ Q E+ R+E+ A + + AL QK+ + +++ + K +
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2183
Query: 117 QEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK 176
E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R + E K
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSK 2242
Query: 177 AQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 233
+A ++ + I R Q+ +++ Q+ E+A +L+ +Q +++
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2300
Score = 40.4 bits (93), Expect = 0.002
Identities = 59/249 (23%), Positives = 108/249 (43%), Gaps = 30/249 (12%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++A QRK LEE + R K V+ R L + E+ + + ++ QK +
Sbjct: 1998 EEAARQRKAALEE---VERLKAKVEEARR-----LRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
E + A + EQ L+ L Q++++ L+ + +A R A +E +E +Q
Sbjct: 2050 EEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQA----- 2100
Query: 129 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 188
+ E A R+V+ ++ E+ + + ++ R+E +A A + A++
Sbjct: 2101 ---EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA-ARRAQAEQAA 2156
Query: 189 FEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHLE---NRKQQLQQEQWYL--ES 239
+ E ++ KK Q + Q Q+LT + LE ++K L +E L E+
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 240 LIQARQRLQ 248
ARQR Q
Sbjct: 2217 TEAARQRSQ 2225
Score = 35.8 bits (81), Expect = 0.042
Identities = 40/174 (22%), Positives = 77/174 (44%), Gaps = 13/174 (7%)
Query: 71 RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKK 130
RR E R AEQ + L + ++++L+++ Q A K + E+E + LQ+ +
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1398
Query: 131 VQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK-RFIF 189
E + E Q+KR ++++L + L + E+ KA+ + A + R
Sbjct: 1399 ---EEVVRREEAAVDAQQQKRSIQEELQQ-----LRQSSEAEIQAKARQAEAAERSRLRI 1450
Query: 190 EYSCGINR-ENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQ 242
E + R + + +++ + Q L A E +K+Q Q+E L +Q
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504
Score = 35.4 bits (80), Expect = 0.055
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 6 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 63
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1110 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1169
Query: 64 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 123
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1225
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 155
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1226 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Score = 35.4 bits (80), Expect = 0.055
Identities = 52/235 (22%), Positives = 100/235 (42%), Gaps = 26/235 (11%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+QA QR +L E+ E R+ A+ R E + TEQ E+ L++ E+
Sbjct: 1681 EQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-RQLLEE--EL 1736
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
R ++E+A+ A +++ +++ L + M + K + E+E ++ E++
Sbjct: 1737 ARLQREAAA-----------ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 129 KKVQAETASKTREV-----QAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK------A 177
K+ A + RE+ + + L E+ ++QL+E D R L K A
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1845
Query: 178 QALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 232
LK A+ + E R + + E Q ++ ++ +E R QL++
Sbjct: 1846 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Score = 34.7 bits (78), Expect = 0.094
Identities = 48/195 (24%), Positives = 87/195 (44%), Gaps = 28/195 (14%)
Query: 67 EIERRRQ--ESASRYAEQ-ISVLKTALLQKENIQSSL--------KRKLQAMRDIAILKE 115
EIER + E R+A+Q I+ +K LQ ++ L K K+Q+ + I
Sbjct: 1257 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI--- 1313
Query: 116 KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRR 171
++ +++T E + ++ E ++ +E+RL E+Q +E RL K+R
Sbjct: 1314 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1373
Query: 172 ELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+L K A+R E Q+ ++E+++ E A + ++ QQL+
Sbjct: 1374 QLAEAHAQAKAQAEREAKEL-------QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1426
Query: 232 QEQWYLESLIQARQR 246
Q E+ IQA+ R
Sbjct: 1427 QSS---EAEIQAKAR 1438
Score = 30.0 bits (66), Expect = 2.3
Identities = 35/160 (21%), Positives = 63/160 (39%), Gaps = 9/160 (5%)
Query: 81 EQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTR 140
EQ+ L L+K S + R Q ++ E+Q KE Q + +++A AS +
Sbjct: 1075 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1134
Query: 141 -----EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK----RFIFEY 191
E Q R + E RL + R++ ++ ++A + +
Sbjct: 1135 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1194
Query: 192 SCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+ RE +Q ++L E A L A R++Q+Q
Sbjct: 1195 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 60.5 bits (145), Expect = 2e-09
Identities = 67/271 (24%), Positives = 122/271 (45%), Gaps = 32/271 (11%)
Query: 17 QLLEESRELHREKLL-VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIER----- 70
+LL++ +EL +E+ +Q + + L +T+ + E L+ S E ER
Sbjct: 2334 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2393
Query: 71 --------RRQESASRYAEQISVL-----KTALLQKENI---QSSLKRKLQAMRDIAILK 114
R +E A R+ +Q + +T L +E + Q+ ++ Q+ D L+
Sbjct: 2394 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2453
Query: 115 E---KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQ-LSEPDRRLLGKRKR 170
E + E+E + LQ+E K +Q ++ Q QLLQE + L++ LSE D L +R
Sbjct: 2454 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2513
Query: 171 RELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRK 227
+ K + L ++A + + E R+ QQ ++E +L+ ++ Q E
Sbjct: 2514 EQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2570
Query: 228 QQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 258
++ Q+E LE + ++ L NQ L Q
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQRLREQ 2601
Score = 55.5 bits (132), Expect = 5e-08
Identities = 60/269 (22%), Positives = 114/269 (42%), Gaps = 36/269 (13%)
Query: 10 QAQTQRKQLLEESRE--LHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 67
QA+ + K+L + +E + RE+ V A+ + +E +Q + + +Q
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAAVDAQQQ------KRSIQEELQQLRQSSEAEIQAKAR 1442
Query: 68 IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE 127
+ S R E+I V++ L E + + +LQA+R A E Q+++ Q E
Sbjct: 1443 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1502
Query: 128 TKKVQAETASKTREVQAQL-----------------LQEKRLLEKQLSEPDRRLLGKRKR 170
++ + + + R+ + +L LQ L Q E +RRL
Sbjct: 1503 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1562
Query: 171 R--------ELNMKAQALKLAAKRFIF-EYSCGINRENQQFKKELLQLIEQAQKLTATQS 221
R E ++ +L +KR F E + + R Q+ + QL E+A++ Q+
Sbjct: 1563 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1622
Query: 222 HLENRKQQLQQ--EQWYLESLIQARQRLQ 248
E +++ ++ E+W L++ R RLQ
Sbjct: 1623 EAERAREEAERELERWQLKANEALRLRLQ 1651
Score = 48.5 bits (114), Expect = 6e-06
Identities = 56/228 (24%), Positives = 106/228 (46%), Gaps = 25/228 (10%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+ AQ RKQ E +LHR +L Q E ++ L + ++ E++ + + E
Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2463
Query: 69 ERRRQES---ASRYAEQISVLKTALLQKENI--QSSLKRKLQAMRDIAILKEKQEKEIQT 123
E+ +QE+ + E +V + LLQ+ QS L K ++ +++++ K Q
Sbjct: 2464 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2523
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRRELNMKAQA 179
Q+E K Q + R+ Q Q+ QE++ L + E RR G R+++E + +
Sbjct: 2524 FQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2582
Query: 180 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ-------AQKLTATQ 220
+ + + E ENQ+ +++L L EQ ++++TA+Q
Sbjct: 2583 QRRQQEELLAE-------ENQRLREQLQLLEEQHRAALAHSEEVTASQ 2623
Score = 46.6 bits (109), Expect = 2e-05
Identities = 58/244 (23%), Positives = 107/244 (43%), Gaps = 29/244 (11%)
Query: 8 IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEYLTNKTEEYT---EQPEKVWNSY 61
++ QR+Q+ EE L EK +AE L + + E+ EQ E
Sbjct: 1917 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976
Query: 62 LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE- 120
Q + E ERRR+E+ R + ++ + A Q++ ++R + + L+E+ E+E
Sbjct: 1977 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2036
Query: 121 ---IQTLQEET-KKVQAE-------TASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 169
+Q QE K++QAE K +E+Q L QE+ +L++ E + +
Sbjct: 2037 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2096
Query: 170 RRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQ 229
E ++A+ ++R + E ++ K+ EQAQ Q+ E +++
Sbjct: 2097 AEEARVQAEREAAQSRRQV--------EEAERLKQ---SAEEQAQARAQAQAAAEKLRKE 2145
Query: 230 LQQE 233
+QE
Sbjct: 2146 AEQE 2149
Score = 44.3 bits (103), Expect = 1e-04
Identities = 50/247 (20%), Positives = 114/247 (46%), Gaps = 19/247 (7%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYL 62
+ + ++QA+ +R + ++ + E + +AE + KT + ++ +
Sbjct: 1551 EAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSLQEEHVAVA 1608
Query: 63 QKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ 122
Q E ERR Q+ A + + + +L+ +LQA ++A Q+K +
Sbjct: 1609 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA-----QQKSLA 1662
Query: 123 TLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALK 181
+ E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L + + ++
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIR 1721
Query: 182 LAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLI 241
L A+ E ++ Q ++EL +L +A T + LE +++ E +E L+
Sbjct: 1722 LRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE---MEVLL 1772
Query: 242 QARQRLQ 248
++ R +
Sbjct: 1773 ASKARAE 1779
Score = 41.6 bits (96), Expect = 8e-04
Identities = 47/238 (19%), Positives = 99/238 (41%), Gaps = 8/238 (3%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHR-----EKLLVQAENRFFLEYL-TNKTEEYTEQPEK 56
+L + ++Q Q+ QL E+ R E+ VQAE + E + E+
Sbjct: 2068 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2127
Query: 57 VWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEK 116
+ Q E+ R+E+ A + + AL QK+ + +++ + K +
Sbjct: 2128 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2187
Query: 117 QEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK 176
E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R + E K
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSK 2246
Query: 177 AQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 233
+A ++ + I R Q+ +++ Q+ E+A +L+ +Q +++
Sbjct: 2247 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2304
Score = 40.4 bits (93), Expect = 0.002
Identities = 59/249 (23%), Positives = 108/249 (43%), Gaps = 30/249 (12%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++A QRK LEE + R K V+ R L + E+ + + ++ QK +
Sbjct: 2002 EEAARQRKAALEE---VERLKAKVEEARR-----LRERAEQESARQLQLAQEAAQKRLQA 2053
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
E + A + EQ L+ L Q++++ L+ + +A R A +E +E +Q
Sbjct: 2054 EEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQA----- 2104
Query: 129 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 188
+ E A R+V+ ++ E+ + + ++ R+E +A A + A++
Sbjct: 2105 ---EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA-ARRAQAEQAA 2160
Query: 189 FEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHLE---NRKQQLQQEQWYL--ES 239
+ E ++ KK Q + Q Q+LT + LE ++K L +E L E+
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2220
Query: 240 LIQARQRLQ 248
ARQR Q
Sbjct: 2221 TEAARQRSQ 2229
Score = 35.8 bits (81), Expect = 0.042
Identities = 40/174 (22%), Positives = 77/174 (44%), Gaps = 13/174 (7%)
Query: 71 RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKK 130
RR E R AEQ + L + ++++L+++ Q A K + E+E + LQ+ +
Sbjct: 1346 RRMEEEERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1402
Query: 131 VQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK-RFIF 189
E + E Q+KR ++++L + L + E+ KA+ + A + R
Sbjct: 1403 ---EEVVRREEAAVDAQQQKRSIQEELQQ-----LRQSSEAEIQAKARQAEAAERSRLRI 1454
Query: 190 EYSCGINR-ENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQ 242
E + R + + +++ + Q L A E +K+Q Q+E L +Q
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1508
Score = 35.4 bits (80), Expect = 0.055
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 6 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 63
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1114 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1173
Query: 64 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 123
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1174 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1229
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 155
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1230 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1261
Score = 35.4 bits (80), Expect = 0.055
Identities = 52/235 (22%), Positives = 100/235 (42%), Gaps = 26/235 (11%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+QA QR +L E+ E R+ A+ R E + TEQ E+ L++ E+
Sbjct: 1685 EQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-RQLLEE--EL 1740
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
R ++E+A+ A +++ +++ L + M + K + E+E ++ E++
Sbjct: 1741 ARLQREAAA-----------ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1789
Query: 129 KKVQAETASKTREV-----QAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK------A 177
K+ A + RE+ + + L E+ ++QL+E D R L K A
Sbjct: 1790 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1849
Query: 178 QALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 232
LK A+ + E R + + E Q ++ ++ +E R QL++
Sbjct: 1850 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1904
Score = 34.7 bits (78), Expect = 0.094
Identities = 48/195 (24%), Positives = 87/195 (44%), Gaps = 28/195 (14%)
Query: 67 EIERRRQ--ESASRYAEQ-ISVLKTALLQKENIQSSL--------KRKLQAMRDIAILKE 115
EIER + E R+A+Q I+ +K LQ ++ L K K+Q+ + I
Sbjct: 1261 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI--- 1317
Query: 116 KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRR 171
++ +++T E + ++ E ++ +E+RL E+Q +E RL K+R
Sbjct: 1318 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1377
Query: 172 ELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+L K A+R E Q+ ++E+++ E A + ++ QQL+
Sbjct: 1378 QLAEAHAQAKAQAEREAKEL-------QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1430
Query: 232 QEQWYLESLIQARQR 246
Q E+ IQA+ R
Sbjct: 1431 QSS---EAEIQAKAR 1442
Score = 30.0 bits (66), Expect = 2.3
Identities = 35/160 (21%), Positives = 63/160 (39%), Gaps = 9/160 (5%)
Query: 81 EQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTR 140
EQ+ L L+K S + R Q ++ E+Q KE Q + +++A AS +
Sbjct: 1079 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1138
Query: 141 -----EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK----RFIFEY 191
E Q R + E RL + R++ ++ ++A + +
Sbjct: 1139 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1198
Query: 192 SCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+ RE +Q ++L E A L A R++Q+Q
Sbjct: 1199 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 60.5 bits (145), Expect = 2e-09
Identities = 67/271 (24%), Positives = 122/271 (45%), Gaps = 32/271 (11%)
Query: 17 QLLEESRELHREKLL-VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIER----- 70
+LL++ +EL +E+ +Q + + L +T+ + E L+ S E ER
Sbjct: 2330 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2389
Query: 71 --------RRQESASRYAEQISVL-----KTALLQKENI---QSSLKRKLQAMRDIAILK 114
R +E A R+ +Q + +T L +E + Q+ ++ Q+ D L+
Sbjct: 2390 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2449
Query: 115 E---KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQ-LSEPDRRLLGKRKR 170
E + E+E + LQ+E K +Q ++ Q QLLQE + L++ LSE D L +R
Sbjct: 2450 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2509
Query: 171 RELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRK 227
+ K + L ++A + + E R+ QQ ++E +L+ ++ Q E
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 228 QQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 258
++ Q+E LE + ++ L NQ L Q
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQ 2597
Score = 55.5 bits (132), Expect = 5e-08
Identities = 60/269 (22%), Positives = 114/269 (42%), Gaps = 36/269 (13%)
Query: 10 QAQTQRKQLLEESRE--LHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 67
QA+ + K+L + +E + RE+ V A+ + +E +Q + + +Q
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQ------KRSIQEELQQLRQSSEAEIQAKAR 1438
Query: 68 IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE 127
+ S R E+I V++ L E + + +LQA+R A E Q+++ Q E
Sbjct: 1439 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1498
Query: 128 TKKVQAETASKTREVQAQL-----------------LQEKRLLEKQLSEPDRRLLGKRKR 170
++ + + + R+ + +L LQ L Q E +RRL
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1558
Query: 171 R--------ELNMKAQALKLAAKRFIF-EYSCGINRENQQFKKELLQLIEQAQKLTATQS 221
R E ++ +L +KR F E + + R Q+ + QL E+A++ Q+
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618
Query: 222 HLENRKQQLQQ--EQWYLESLIQARQRLQ 248
E +++ ++ E+W L++ R RLQ
Sbjct: 1619 EAERAREEAERELERWQLKANEALRLRLQ 1647
Score = 48.5 bits (114), Expect = 6e-06
Identities = 56/228 (24%), Positives = 106/228 (46%), Gaps = 25/228 (10%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+ AQ RKQ E +LHR +L Q E ++ L + ++ E++ + + E
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 69 ERRRQES---ASRYAEQISVLKTALLQKENI--QSSLKRKLQAMRDIAILKEKQEKEIQT 123
E+ +QE+ + E +V + LLQ+ QS L K ++ +++++ K Q
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRRELNMKAQA 179
Q+E K Q + R+ Q Q+ QE++ L + E RR G R+++E + +
Sbjct: 2520 FQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578
Query: 180 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ-------AQKLTATQ 220
+ + + E ENQ+ +++L L EQ ++++TA+Q
Sbjct: 2579 QRRQQEELLAE-------ENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Score = 46.6 bits (109), Expect = 2e-05
Identities = 58/244 (23%), Positives = 107/244 (43%), Gaps = 29/244 (11%)
Query: 8 IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEYLTNKTEEYT---EQPEKVWNSY 61
++ QR+Q+ EE L EK +AE L + + E+ EQ E
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 62 LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE- 120
Q + E ERRR+E+ R + ++ + A Q++ ++R + + L+E+ E+E
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032
Query: 121 ---IQTLQEET-KKVQAE-------TASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 169
+Q QE K++QAE K +E+Q L QE+ +L++ E + +
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092
Query: 170 RRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQ 229
E ++A+ ++R + E ++ K+ EQAQ Q+ E +++
Sbjct: 2093 AEEARVQAEREAAQSRRQV--------EEAERLKQ---SAEEQAQARAQAQAAAEKLRKE 2141
Query: 230 LQQE 233
+QE
Sbjct: 2142 AEQE 2145
Score = 44.3 bits (103), Expect = 1e-04
Identities = 50/247 (20%), Positives = 114/247 (46%), Gaps = 19/247 (7%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYL 62
+ + ++QA+ +R + ++ + E + +AE + KT + ++ +
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSLQEEHVAVA 1604
Query: 63 QKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ 122
Q E ERR Q+ A + + + +L+ +LQA ++A Q+K +
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA-----QQKSLA 1658
Query: 123 TLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALK 181
+ E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L + + ++
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIR 1717
Query: 182 LAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLI 241
L A+ E ++ Q ++EL +L +A T + LE +++ E +E L+
Sbjct: 1718 LRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE---MEVLL 1768
Query: 242 QARQRLQ 248
++ R +
Sbjct: 1769 ASKARAE 1775
Score = 41.6 bits (96), Expect = 8e-04
Identities = 47/238 (19%), Positives = 99/238 (41%), Gaps = 8/238 (3%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHR-----EKLLVQAENRFFLEYL-TNKTEEYTEQPEK 56
+L + ++Q Q+ QL E+ R E+ VQAE + E + E+
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 57 VWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEK 116
+ Q E+ R+E+ A + + AL QK+ + +++ + K +
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2183
Query: 117 QEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK 176
E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R + E K
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSK 2242
Query: 177 AQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 233
+A ++ + I R Q+ +++ Q+ E+A +L+ +Q +++
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2300
Score = 40.4 bits (93), Expect = 0.002
Identities = 59/249 (23%), Positives = 108/249 (43%), Gaps = 30/249 (12%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++A QRK LEE + R K V+ R L + E+ + + ++ QK +
Sbjct: 1998 EEAARQRKAALEE---VERLKAKVEEARR-----LRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
E + A + EQ L+ L Q++++ L+ + +A R A +E +E +Q
Sbjct: 2050 EEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQA----- 2100
Query: 129 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 188
+ E A R+V+ ++ E+ + + ++ R+E +A A + A++
Sbjct: 2101 ---EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA-ARRAQAEQAA 2156
Query: 189 FEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHLE---NRKQQLQQEQWYL--ES 239
+ E ++ KK Q + Q Q+LT + LE ++K L +E L E+
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 240 LIQARQRLQ 248
ARQR Q
Sbjct: 2217 TEAARQRSQ 2225
Score = 35.8 bits (81), Expect = 0.042
Identities = 40/174 (22%), Positives = 77/174 (44%), Gaps = 13/174 (7%)
Query: 71 RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKK 130
RR E R AEQ + L + ++++L+++ Q A K + E+E + LQ+ +
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1398
Query: 131 VQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK-RFIF 189
E + E Q+KR ++++L + L + E+ KA+ + A + R
Sbjct: 1399 ---EEVVRREEAAVDAQQQKRSIQEELQQ-----LRQSSEAEIQAKARQAEAAERSRLRI 1450
Query: 190 EYSCGINR-ENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQ 242
E + R + + +++ + Q L A E +K+Q Q+E L +Q
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504
Score = 35.4 bits (80), Expect = 0.055
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 6 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 63
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1110 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1169
Query: 64 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 123
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1225
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 155
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1226 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Score = 35.4 bits (80), Expect = 0.055
Identities = 52/235 (22%), Positives = 100/235 (42%), Gaps = 26/235 (11%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+QA QR +L E+ E R+ A+ R E + TEQ E+ L++ E+
Sbjct: 1681 EQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-RQLLEE--EL 1736
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
R ++E+A+ A +++ +++ L + M + K + E+E ++ E++
Sbjct: 1737 ARLQREAAA-----------ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 129 KKVQAETASKTREV-----QAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK------A 177
K+ A + RE+ + + L E+ ++QL+E D R L K A
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1845
Query: 178 QALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 232
LK A+ + E R + + E Q ++ ++ +E R QL++
Sbjct: 1846 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Score = 34.7 bits (78), Expect = 0.094
Identities = 48/195 (24%), Positives = 87/195 (44%), Gaps = 28/195 (14%)
Query: 67 EIERRRQ--ESASRYAEQ-ISVLKTALLQKENIQSSL--------KRKLQAMRDIAILKE 115
EIER + E R+A+Q I+ +K LQ ++ L K K+Q+ + I
Sbjct: 1257 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI--- 1313
Query: 116 KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRR 171
++ +++T E + ++ E ++ +E+RL E+Q +E RL K+R
Sbjct: 1314 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1373
Query: 172 ELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+L K A+R E Q+ ++E+++ E A + ++ QQL+
Sbjct: 1374 QLAEAHAQAKAQAEREAKEL-------QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1426
Query: 232 QEQWYLESLIQARQR 246
Q E+ IQA+ R
Sbjct: 1427 QSS---EAEIQAKAR 1438
Score = 30.0 bits (66), Expect = 2.3
Identities = 35/160 (21%), Positives = 63/160 (39%), Gaps = 9/160 (5%)
Query: 81 EQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTR 140
EQ+ L L+K S + R Q ++ E+Q KE Q + +++A AS +
Sbjct: 1075 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1134
Query: 141 -----EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK----RFIFEY 191
E Q R + E RL + R++ ++ ++A + +
Sbjct: 1135 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1194
Query: 192 SCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+ RE +Q ++L E A L A R++Q+Q
Sbjct: 1195 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 60.5 bits (145), Expect = 2e-09
Identities = 67/271 (24%), Positives = 122/271 (45%), Gaps = 32/271 (11%)
Query: 17 QLLEESRELHREKLL-VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIER----- 70
+LL++ +EL +E+ +Q + + L +T+ + E L+ S E ER
Sbjct: 2298 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2357
Query: 71 --------RRQESASRYAEQISVL-----KTALLQKENI---QSSLKRKLQAMRDIAILK 114
R +E A R+ +Q + +T L +E + Q+ ++ Q+ D L+
Sbjct: 2358 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2417
Query: 115 E---KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQ-LSEPDRRLLGKRKR 170
E + E+E + LQ+E K +Q ++ Q QLLQE + L++ LSE D L +R
Sbjct: 2418 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2477
Query: 171 RELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRK 227
+ K + L ++A + + E R+ QQ ++E +L+ ++ Q E
Sbjct: 2478 EQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2534
Query: 228 QQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 258
++ Q+E LE + ++ L NQ L Q
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQRLREQ 2565
Score = 55.5 bits (132), Expect = 5e-08
Identities = 60/269 (22%), Positives = 114/269 (42%), Gaps = 36/269 (13%)
Query: 10 QAQTQRKQLLEESRE--LHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 67
QA+ + K+L + +E + RE+ V A+ + +E +Q + + +Q
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAAVDAQQQ------KRSIQEELQQLRQSSEAEIQAKAR 1406
Query: 68 IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE 127
+ S R E+I V++ L E + + +LQA+R A E Q+++ Q E
Sbjct: 1407 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1466
Query: 128 TKKVQAETASKTREVQAQL-----------------LQEKRLLEKQLSEPDRRLLGKRKR 170
++ + + + R+ + +L LQ L Q E +RRL
Sbjct: 1467 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1526
Query: 171 R--------ELNMKAQALKLAAKRFIF-EYSCGINRENQQFKKELLQLIEQAQKLTATQS 221
R E ++ +L +KR F E + + R Q+ + QL E+A++ Q+
Sbjct: 1527 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1586
Query: 222 HLENRKQQLQQ--EQWYLESLIQARQRLQ 248
E +++ ++ E+W L++ R RLQ
Sbjct: 1587 EAERAREEAERELERWQLKANEALRLRLQ 1615
Score = 48.5 bits (114), Expect = 6e-06
Identities = 56/228 (24%), Positives = 106/228 (46%), Gaps = 25/228 (10%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+ AQ RKQ E +LHR +L Q E ++ L + ++ E++ + + E
Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2427
Query: 69 ERRRQES---ASRYAEQISVLKTALLQKENI--QSSLKRKLQAMRDIAILKEKQEKEIQT 123
E+ +QE+ + E +V + LLQ+ QS L K ++ +++++ K Q
Sbjct: 2428 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2487
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRRELNMKAQA 179
Q+E K Q + R+ Q Q+ QE++ L + E RR G R+++E + +
Sbjct: 2488 FQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2546
Query: 180 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ-------AQKLTATQ 220
+ + + E ENQ+ +++L L EQ ++++TA+Q
Sbjct: 2547 QRRQQEELLAE-------ENQRLREQLQLLEEQHRAALAHSEEVTASQ 2587
Score = 46.6 bits (109), Expect = 2e-05
Identities = 58/244 (23%), Positives = 107/244 (43%), Gaps = 29/244 (11%)
Query: 8 IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEYLTNKTEEYT---EQPEKVWNSY 61
++ QR+Q+ EE L EK +AE L + + E+ EQ E
Sbjct: 1881 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1940
Query: 62 LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE- 120
Q + E ERRR+E+ R + ++ + A Q++ ++R + + L+E+ E+E
Sbjct: 1941 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2000
Query: 121 ---IQTLQEET-KKVQAE-------TASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 169
+Q QE K++QAE K +E+Q L QE+ +L++ E + +
Sbjct: 2001 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2060
Query: 170 RRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQ 229
E ++A+ ++R + E ++ K+ EQAQ Q+ E +++
Sbjct: 2061 AEEARVQAEREAAQSRRQV--------EEAERLKQ---SAEEQAQARAQAQAAAEKLRKE 2109
Query: 230 LQQE 233
+QE
Sbjct: 2110 AEQE 2113
Score = 44.3 bits (103), Expect = 1e-04
Identities = 50/247 (20%), Positives = 114/247 (46%), Gaps = 19/247 (7%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYL 62
+ + ++QA+ +R + ++ + E + +AE + KT + ++ +
Sbjct: 1515 EAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSLQEEHVAVA 1572
Query: 63 QKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ 122
Q E ERR Q+ A + + + +L+ +LQA ++A Q+K +
Sbjct: 1573 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA-----QQKSLA 1626
Query: 123 TLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALK 181
+ E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L + + ++
Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIR 1685
Query: 182 LAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLI 241
L A+ E ++ Q ++EL +L +A T + LE +++ E +E L+
Sbjct: 1686 LRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE---MEVLL 1736
Query: 242 QARQRLQ 248
++ R +
Sbjct: 1737 ASKARAE 1743
Score = 41.6 bits (96), Expect = 8e-04
Identities = 47/238 (19%), Positives = 99/238 (41%), Gaps = 8/238 (3%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHR-----EKLLVQAENRFFLEYL-TNKTEEYTEQPEK 56
+L + ++Q Q+ QL E+ R E+ VQAE + E + E+
Sbjct: 2032 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2091
Query: 57 VWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEK 116
+ Q E+ R+E+ A + + AL QK+ + +++ + K +
Sbjct: 2092 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2151
Query: 117 QEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK 176
E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R + E K
Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSK 2210
Query: 177 AQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 233
+A ++ + I R Q+ +++ Q+ E+A +L+ +Q +++
Sbjct: 2211 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2268
Score = 40.4 bits (93), Expect = 0.002
Identities = 59/249 (23%), Positives = 108/249 (43%), Gaps = 30/249 (12%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++A QRK LEE + R K V+ R L + E+ + + ++ QK +
Sbjct: 1966 EEAARQRKAALEE---VERLKAKVEEARR-----LRERAEQESARQLQLAQEAAQKRLQA 2017
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
E + A + EQ L+ L Q++++ L+ + +A R A +E +E +Q
Sbjct: 2018 EEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQA----- 2068
Query: 129 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 188
+ E A R+V+ ++ E+ + + ++ R+E +A A + A++
Sbjct: 2069 ---EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA-ARRAQAEQAA 2124
Query: 189 FEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHLE---NRKQQLQQEQWYL--ES 239
+ E ++ KK Q + Q Q+LT + LE ++K L +E L E+
Sbjct: 2125 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2184
Query: 240 LIQARQRLQ 248
ARQR Q
Sbjct: 2185 TEAARQRSQ 2193
Score = 35.8 bits (81), Expect = 0.042
Identities = 40/174 (22%), Positives = 77/174 (44%), Gaps = 13/174 (7%)
Query: 71 RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKK 130
RR E R AEQ + L + ++++L+++ Q A K + E+E + LQ+ +
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1366
Query: 131 VQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK-RFIF 189
E + E Q+KR ++++L + L + E+ KA+ + A + R
Sbjct: 1367 ---EEVVRREEAAVDAQQQKRSIQEELQQ-----LRQSSEAEIQAKARQAEAAERSRLRI 1418
Query: 190 EYSCGINR-ENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQ 242
E + R + + +++ + Q L A E +K+Q Q+E L +Q
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1472
Score = 35.4 bits (80), Expect = 0.055
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 6 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 63
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1078 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1137
Query: 64 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 123
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1138 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1193
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 155
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1194 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1225
Score = 35.4 bits (80), Expect = 0.055
Identities = 52/235 (22%), Positives = 100/235 (42%), Gaps = 26/235 (11%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+QA QR +L E+ E R+ A+ R E + TEQ E+ L++ E+
Sbjct: 1649 EQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-RQLLEE--EL 1704
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
R ++E+A+ A +++ +++ L + M + K + E+E ++ E++
Sbjct: 1705 ARLQREAAA-----------ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1753
Query: 129 KKVQAETASKTREV-----QAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK------A 177
K+ A + RE+ + + L E+ ++QL+E D R L K A
Sbjct: 1754 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1813
Query: 178 QALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 232
LK A+ + E R + + E Q ++ ++ +E R QL++
Sbjct: 1814 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1868
Score = 34.7 bits (78), Expect = 0.094
Identities = 48/195 (24%), Positives = 87/195 (44%), Gaps = 28/195 (14%)
Query: 67 EIERRRQ--ESASRYAEQ-ISVLKTALLQKENIQSSL--------KRKLQAMRDIAILKE 115
EIER + E R+A+Q I+ +K LQ ++ L K K+Q+ + I
Sbjct: 1225 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI--- 1281
Query: 116 KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRR 171
++ +++T E + ++ E ++ +E+RL E+Q +E RL K+R
Sbjct: 1282 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1341
Query: 172 ELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+L K A+R E Q+ ++E+++ E A + ++ QQL+
Sbjct: 1342 QLAEAHAQAKAQAEREAKEL-------QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1394
Query: 232 QEQWYLESLIQARQR 246
Q E+ IQA+ R
Sbjct: 1395 QSS---EAEIQAKAR 1406
Score = 30.0 bits (66), Expect = 2.3
Identities = 35/160 (21%), Positives = 63/160 (39%), Gaps = 9/160 (5%)
Query: 81 EQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTR 140
EQ+ L L+K S + R Q ++ E+Q KE Q + +++A AS +
Sbjct: 1043 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1102
Query: 141 -----EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK----RFIFEY 191
E Q R + E RL + R++ ++ ++A + +
Sbjct: 1103 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1162
Query: 192 SCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+ RE +Q ++L E A L A R++Q+Q
Sbjct: 1163 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1202
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 60.5 bits (145), Expect = 2e-09
Identities = 67/271 (24%), Positives = 122/271 (45%), Gaps = 32/271 (11%)
Query: 17 QLLEESRELHREKLL-VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIER----- 70
+LL++ +EL +E+ +Q + + L +T+ + E L+ S E ER
Sbjct: 2467 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2526
Query: 71 --------RRQESASRYAEQISVL-----KTALLQKENI---QSSLKRKLQAMRDIAILK 114
R +E A R+ +Q + +T L +E + Q+ ++ Q+ D L+
Sbjct: 2527 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2586
Query: 115 E---KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQ-LSEPDRRLLGKRKR 170
E + E+E + LQ+E K +Q ++ Q QLLQE + L++ LSE D L +R
Sbjct: 2587 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2646
Query: 171 RELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRK 227
+ K + L ++A + + E R+ QQ ++E +L+ ++ Q E
Sbjct: 2647 EQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2703
Query: 228 QQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 258
++ Q+E LE + ++ L NQ L Q
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLREQ 2734
Score = 55.5 bits (132), Expect = 5e-08
Identities = 60/269 (22%), Positives = 114/269 (42%), Gaps = 36/269 (13%)
Query: 10 QAQTQRKQLLEESRE--LHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 67
QA+ + K+L + +E + RE+ V A+ + +E +Q + + +Q
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAAVDAQQQ------KRSIQEELQQLRQSSEAEIQAKAR 1575
Query: 68 IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE 127
+ S R E+I V++ L E + + +LQA+R A E Q+++ Q E
Sbjct: 1576 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1635
Query: 128 TKKVQAETASKTREVQAQL-----------------LQEKRLLEKQLSEPDRRLLGKRKR 170
++ + + + R+ + +L LQ L Q E +RRL
Sbjct: 1636 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1695
Query: 171 R--------ELNMKAQALKLAAKRFIF-EYSCGINRENQQFKKELLQLIEQAQKLTATQS 221
R E ++ +L +KR F E + + R Q+ + QL E+A++ Q+
Sbjct: 1696 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1755
Query: 222 HLENRKQQLQQ--EQWYLESLIQARQRLQ 248
E +++ ++ E+W L++ R RLQ
Sbjct: 1756 EAERAREEAERELERWQLKANEALRLRLQ 1784
Score = 48.5 bits (114), Expect = 6e-06
Identities = 56/228 (24%), Positives = 106/228 (46%), Gaps = 25/228 (10%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+ AQ RKQ E +LHR +L Q E ++ L + ++ E++ + + E
Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2596
Query: 69 ERRRQES---ASRYAEQISVLKTALLQKENI--QSSLKRKLQAMRDIAILKEKQEKEIQT 123
E+ +QE+ + E +V + LLQ+ QS L K ++ +++++ K Q
Sbjct: 2597 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2656
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRRELNMKAQA 179
Q+E K Q + R+ Q Q+ QE++ L + E RR G R+++E + +
Sbjct: 2657 FQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2715
Query: 180 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ-------AQKLTATQ 220
+ + + E ENQ+ +++L L EQ ++++TA+Q
Sbjct: 2716 QRRQQEELLAE-------ENQRLREQLQLLEEQHRAALAHSEEVTASQ 2756
Score = 46.6 bits (109), Expect = 2e-05
Identities = 58/244 (23%), Positives = 107/244 (43%), Gaps = 29/244 (11%)
Query: 8 IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEYLTNKTEEYT---EQPEKVWNSY 61
++ QR+Q+ EE L EK +AE L + + E+ EQ E
Sbjct: 2050 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 2109
Query: 62 LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE- 120
Q + E ERRR+E+ R + ++ + A Q++ ++R + + L+E+ E+E
Sbjct: 2110 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2169
Query: 121 ---IQTLQEET-KKVQAE-------TASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 169
+Q QE K++QAE K +E+Q L QE+ +L++ E + +
Sbjct: 2170 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2229
Query: 170 RRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQ 229
E ++A+ ++R + E ++ K+ EQAQ Q+ E +++
Sbjct: 2230 AEEARVQAEREAAQSRRQV--------EEAERLKQ---SAEEQAQARAQAQAAAEKLRKE 2278
Query: 230 LQQE 233
+QE
Sbjct: 2279 AEQE 2282
Score = 44.3 bits (103), Expect = 1e-04
Identities = 50/247 (20%), Positives = 114/247 (46%), Gaps = 19/247 (7%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYL 62
+ + ++QA+ +R + ++ + E + +AE + KT + ++ +
Sbjct: 1684 EAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSLQEEHVAVA 1741
Query: 63 QKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ 122
Q E ERR Q+ A + + + +L+ +LQA ++A Q+K +
Sbjct: 1742 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA-----QQKSLA 1795
Query: 123 TLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALK 181
+ E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L + + ++
Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIR 1854
Query: 182 LAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLI 241
L A+ E ++ Q ++EL +L +A T + LE +++ E +E L+
Sbjct: 1855 LRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE---MEVLL 1905
Query: 242 QARQRLQ 248
++ R +
Sbjct: 1906 ASKARAE 1912
Score = 41.6 bits (96), Expect = 8e-04
Identities = 47/238 (19%), Positives = 99/238 (41%), Gaps = 8/238 (3%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHR-----EKLLVQAENRFFLEYL-TNKTEEYTEQPEK 56
+L + ++Q Q+ QL E+ R E+ VQAE + E + E+
Sbjct: 2201 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260
Query: 57 VWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEK 116
+ Q E+ R+E+ A + + AL QK+ + +++ + K +
Sbjct: 2261 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2320
Query: 117 QEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK 176
E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R + E K
Sbjct: 2321 VEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSK 2379
Query: 177 AQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 233
+A ++ + I R Q+ +++ Q+ E+A +L+ +Q +++
Sbjct: 2380 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2437
Score = 40.4 bits (93), Expect = 0.002
Identities = 59/249 (23%), Positives = 108/249 (43%), Gaps = 30/249 (12%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++A QRK LEE + R K V+ R L + E+ + + ++ QK +
Sbjct: 2135 EEAARQRKAALEE---VERLKAKVEEARR-----LRERAEQESARQLQLAQEAAQKRLQA 2186
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
E + A + EQ L+ L Q++++ L+ + +A R A +E +E +Q
Sbjct: 2187 EEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQA----- 2237
Query: 129 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 188
+ E A R+V+ ++ E+ + + ++ R+E +A A + A++
Sbjct: 2238 ---EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA-ARRAQAEQAA 2293
Query: 189 FEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHLE---NRKQQLQQEQWYL--ES 239
+ E ++ KK Q + Q Q+LT + LE ++K L +E L E+
Sbjct: 2294 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2353
Query: 240 LIQARQRLQ 248
ARQR Q
Sbjct: 2354 TEAARQRSQ 2362
Score = 35.8 bits (81), Expect = 0.042
Identities = 40/174 (22%), Positives = 77/174 (44%), Gaps = 13/174 (7%)
Query: 71 RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKK 130
RR E R AEQ + L + ++++L+++ Q A K + E+E + LQ+ +
Sbjct: 1479 RRMEEEERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1535
Query: 131 VQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK-RFIF 189
E + E Q+KR ++++L + L + E+ KA+ + A + R
Sbjct: 1536 ---EEVVRREEAAVDAQQQKRSIQEELQQ-----LRQSSEAEIQAKARQAEAAERSRLRI 1587
Query: 190 EYSCGINR-ENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQ 242
E + R + + +++ + Q L A E +K+Q Q+E L +Q
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1641
Score = 35.4 bits (80), Expect = 0.055
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 6 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 63
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1247 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1306
Query: 64 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 123
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1307 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1362
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 155
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1363 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1394
Score = 35.4 bits (80), Expect = 0.055
Identities = 52/235 (22%), Positives = 100/235 (42%), Gaps = 26/235 (11%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+QA QR +L E+ E R+ A+ R E + TEQ E+ L++ E+
Sbjct: 1818 EQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-RQLLEE--EL 1873
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
R ++E+A+ A +++ +++ L + M + K + E+E ++ E++
Sbjct: 1874 ARLQREAAA-----------ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1922
Query: 129 KKVQAETASKTREV-----QAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK------A 177
K+ A + RE+ + + L E+ ++QL+E D R L K A
Sbjct: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1982
Query: 178 QALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 232
LK A+ + E R + + E Q ++ ++ +E R QL++
Sbjct: 1983 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 2037
Score = 34.7 bits (78), Expect = 0.094
Identities = 48/195 (24%), Positives = 87/195 (44%), Gaps = 28/195 (14%)
Query: 67 EIERRRQ--ESASRYAEQ-ISVLKTALLQKENIQSSL--------KRKLQAMRDIAILKE 115
EIER + E R+A+Q I+ +K LQ ++ L K K+Q+ + I
Sbjct: 1394 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI--- 1450
Query: 116 KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRR 171
++ +++T E + ++ E ++ +E+RL E+Q +E RL K+R
Sbjct: 1451 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1510
Query: 172 ELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+L K A+R E Q+ ++E+++ E A + ++ QQL+
Sbjct: 1511 QLAEAHAQAKAQAEREAKEL-------QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1563
Query: 232 QEQWYLESLIQARQR 246
Q E+ IQA+ R
Sbjct: 1564 QSS---EAEIQAKAR 1575
Score = 30.0 bits (66), Expect = 2.3
Identities = 35/160 (21%), Positives = 63/160 (39%), Gaps = 9/160 (5%)
Query: 81 EQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTR 140
EQ+ L L+K S + R Q ++ E+Q KE Q + +++A AS +
Sbjct: 1212 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1271
Query: 141 -----EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK----RFIFEY 191
E Q R + E RL + R++ ++ ++A + +
Sbjct: 1272 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1331
Query: 192 SCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+ RE +Q ++L E A L A R++Q+Q
Sbjct: 1332 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 60.5 bits (145), Expect = 2e-09
Identities = 67/271 (24%), Positives = 122/271 (45%), Gaps = 32/271 (11%)
Query: 17 QLLEESRELHREKLL-VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIER----- 70
+LL++ +EL +E+ +Q + + L +T+ + E L+ S E ER
Sbjct: 2308 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2367
Query: 71 --------RRQESASRYAEQISVL-----KTALLQKENI---QSSLKRKLQAMRDIAILK 114
R +E A R+ +Q + +T L +E + Q+ ++ Q+ D L+
Sbjct: 2368 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2427
Query: 115 E---KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQ-LSEPDRRLLGKRKR 170
E + E+E + LQ+E K +Q ++ Q QLLQE + L++ LSE D L +R
Sbjct: 2428 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2487
Query: 171 RELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRK 227
+ K + L ++A + + E R+ QQ ++E +L+ ++ Q E
Sbjct: 2488 EQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2544
Query: 228 QQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 258
++ Q+E LE + ++ L NQ L Q
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLREQ 2575
Score = 55.5 bits (132), Expect = 5e-08
Identities = 60/269 (22%), Positives = 114/269 (42%), Gaps = 36/269 (13%)
Query: 10 QAQTQRKQLLEESRE--LHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 67
QA+ + K+L + +E + RE+ V A+ + +E +Q + + +Q
Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAAVDAQQQ------KRSIQEELQQLRQSSEAEIQAKAR 1416
Query: 68 IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE 127
+ S R E+I V++ L E + + +LQA+R A E Q+++ Q E
Sbjct: 1417 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1476
Query: 128 TKKVQAETASKTREVQAQL-----------------LQEKRLLEKQLSEPDRRLLGKRKR 170
++ + + + R+ + +L LQ L Q E +RRL
Sbjct: 1477 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1536
Query: 171 R--------ELNMKAQALKLAAKRFIF-EYSCGINRENQQFKKELLQLIEQAQKLTATQS 221
R E ++ +L +KR F E + + R Q+ + QL E+A++ Q+
Sbjct: 1537 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1596
Query: 222 HLENRKQQLQQ--EQWYLESLIQARQRLQ 248
E +++ ++ E+W L++ R RLQ
Sbjct: 1597 EAERAREEAERELERWQLKANEALRLRLQ 1625
Score = 48.5 bits (114), Expect = 6e-06
Identities = 56/228 (24%), Positives = 106/228 (46%), Gaps = 25/228 (10%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+ AQ RKQ E +LHR +L Q E ++ L + ++ E++ + + E
Sbjct: 2379 EDAQRFRKQAEEIGEKLHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2437
Query: 69 ERRRQES---ASRYAEQISVLKTALLQKENI--QSSLKRKLQAMRDIAILKEKQEKEIQT 123
E+ +QE+ + E +V + LLQ+ QS L K ++ +++++ K Q
Sbjct: 2438 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2497
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRRELNMKAQA 179
Q+E K Q + R+ Q Q+ QE++ L + E RR G R+++E + +
Sbjct: 2498 FQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2556
Query: 180 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ-------AQKLTATQ 220
+ + + E ENQ+ +++L L EQ ++++TA+Q
Sbjct: 2557 QRRQQEELLAE-------ENQRLREQLQLLEEQHRAALAHSEEVTASQ 2597
Score = 46.6 bits (109), Expect = 2e-05
Identities = 58/244 (23%), Positives = 107/244 (43%), Gaps = 29/244 (11%)
Query: 8 IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEYLTNKTEEYT---EQPEKVWNSY 61
++ QR+Q+ EE L EK +AE L + + E+ EQ E
Sbjct: 1891 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1950
Query: 62 LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE- 120
Q + E ERRR+E+ R + ++ + A Q++ ++R + + L+E+ E+E
Sbjct: 1951 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2010
Query: 121 ---IQTLQEET-KKVQAE-------TASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 169
+Q QE K++QAE K +E+Q L QE+ +L++ E + +
Sbjct: 2011 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2070
Query: 170 RRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQ 229
E ++A+ ++R + E ++ K+ EQAQ Q+ E +++
Sbjct: 2071 AEEARVQAEREAAQSRRQV--------EEAERLKQ---SAEEQAQARAQAQAAAEKLRKE 2119
Query: 230 LQQE 233
+QE
Sbjct: 2120 AEQE 2123
Score = 44.3 bits (103), Expect = 1e-04
Identities = 50/247 (20%), Positives = 114/247 (46%), Gaps = 19/247 (7%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYL 62
+ + ++QA+ +R + ++ + E + +AE + KT + ++ +
Sbjct: 1525 EAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSLQEEHVAVA 1582
Query: 63 QKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ 122
Q E ERR Q+ A + + + +L+ +LQA ++A Q+K +
Sbjct: 1583 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA-----QQKSLA 1636
Query: 123 TLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALK 181
+ E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L + + ++
Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIR 1695
Query: 182 LAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLI 241
L A+ E ++ Q ++EL +L +A T + LE +++ E +E L+
Sbjct: 1696 LRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE---MEVLL 1746
Query: 242 QARQRLQ 248
++ R +
Sbjct: 1747 ASKARAE 1753
Score = 41.6 bits (96), Expect = 8e-04
Identities = 47/238 (19%), Positives = 99/238 (41%), Gaps = 8/238 (3%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHR-----EKLLVQAENRFFLEYL-TNKTEEYTEQPEK 56
+L + ++Q Q+ QL E+ R E+ VQAE + E + E+
Sbjct: 2042 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101
Query: 57 VWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEK 116
+ Q E+ R+E+ A + + AL QK+ + +++ + K +
Sbjct: 2102 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2161
Query: 117 QEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK 176
E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R + E K
Sbjct: 2162 VEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSK 2220
Query: 177 AQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 233
+A ++ + I R Q+ +++ Q+ E+A +L+ +Q +++
Sbjct: 2221 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2278
Score = 40.4 bits (93), Expect = 0.002
Identities = 59/249 (23%), Positives = 108/249 (43%), Gaps = 30/249 (12%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++A QRK LEE + R K V+ R L + E+ + + ++ QK +
Sbjct: 1976 EEAARQRKAALEE---VERLKAKVEEARR-----LRERAEQESARQLQLAQEAAQKRLQA 2027
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
E + A + EQ L+ L Q++++ L+ + +A R A +E +E +Q
Sbjct: 2028 EEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQA----- 2078
Query: 129 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 188
+ E A R+V+ ++ E+ + + ++ R+E +A A + A++
Sbjct: 2079 ---EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA-ARRAQAEQAA 2134
Query: 189 FEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHLE---NRKQQLQQEQWYL--ES 239
+ E ++ KK Q + Q Q+LT + LE ++K L +E L E+
Sbjct: 2135 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2194
Query: 240 LIQARQRLQ 248
ARQR Q
Sbjct: 2195 TEAARQRSQ 2203
Score = 35.8 bits (81), Expect = 0.042
Identities = 40/174 (22%), Positives = 77/174 (44%), Gaps = 13/174 (7%)
Query: 71 RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKK 130
RR E R AEQ + L + ++++L+++ Q A K + E+E + LQ+ +
Sbjct: 1320 RRMEEEERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1376
Query: 131 VQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK-RFIF 189
E + E Q+KR ++++L + L + E+ KA+ + A + R
Sbjct: 1377 ---EEVVRREEAAVDAQQQKRSIQEELQQ-----LRQSSEAEIQAKARQAEAAERSRLRI 1428
Query: 190 EYSCGINR-ENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQ 242
E + R + + +++ + Q L A E +K+Q Q+E L +Q
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1482
Score = 35.4 bits (80), Expect = 0.055
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 6 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 63
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1088 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1147
Query: 64 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 123
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1148 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1203
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 155
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1204 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1235
Score = 35.4 bits (80), Expect = 0.055
Identities = 52/235 (22%), Positives = 100/235 (42%), Gaps = 26/235 (11%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+QA QR +L E+ E R+ A+ R E + TEQ E+ L++ E+
Sbjct: 1659 EQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-RQLLEE--EL 1714
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
R ++E+A+ A +++ +++ L + M + K + E+E ++ E++
Sbjct: 1715 ARLQREAAA-----------ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1763
Query: 129 KKVQAETASKTREV-----QAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK------A 177
K+ A + RE+ + + L E+ ++QL+E D R L K A
Sbjct: 1764 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1823
Query: 178 QALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 232
LK A+ + E R + + E Q ++ ++ +E R QL++
Sbjct: 1824 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1878
Score = 34.7 bits (78), Expect = 0.094
Identities = 48/195 (24%), Positives = 87/195 (44%), Gaps = 28/195 (14%)
Query: 67 EIERRRQ--ESASRYAEQ-ISVLKTALLQKENIQSSL--------KRKLQAMRDIAILKE 115
EIER + E R+A+Q I+ +K LQ ++ L K K+Q+ + I
Sbjct: 1235 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI--- 1291
Query: 116 KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRR 171
++ +++T E + ++ E ++ +E+RL E+Q +E RL K+R
Sbjct: 1292 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1351
Query: 172 ELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+L K A+R E Q+ ++E+++ E A + ++ QQL+
Sbjct: 1352 QLAEAHAQAKAQAEREAKEL-------QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1404
Query: 232 QEQWYLESLIQARQR 246
Q E+ IQA+ R
Sbjct: 1405 QSS---EAEIQAKAR 1416
Score = 30.0 bits (66), Expect = 2.3
Identities = 35/160 (21%), Positives = 63/160 (39%), Gaps = 9/160 (5%)
Query: 81 EQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTR 140
EQ+ L L+K S + R Q ++ E+Q KE Q + +++A AS +
Sbjct: 1053 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1112
Query: 141 -----EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK----RFIFEY 191
E Q R + E RL + R++ ++ ++A + +
Sbjct: 1113 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1172
Query: 192 SCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+ RE +Q ++L E A L A R++Q+Q
Sbjct: 1173 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1212
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 60.5 bits (145), Expect = 2e-09
Identities = 67/271 (24%), Positives = 122/271 (45%), Gaps = 32/271 (11%)
Query: 17 QLLEESRELHREKLL-VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIER----- 70
+LL++ +EL +E+ +Q + + L +T+ + E L+ S E ER
Sbjct: 2316 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2375
Query: 71 --------RRQESASRYAEQISVL-----KTALLQKENI---QSSLKRKLQAMRDIAILK 114
R +E A R+ +Q + +T L +E + Q+ ++ Q+ D L+
Sbjct: 2376 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2435
Query: 115 E---KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQ-LSEPDRRLLGKRKR 170
E + E+E + LQ+E K +Q ++ Q QLLQE + L++ LSE D L +R
Sbjct: 2436 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2495
Query: 171 RELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRK 227
+ K + L ++A + + E R+ QQ ++E +L+ ++ Q E
Sbjct: 2496 EQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2552
Query: 228 QQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 258
++ Q+E LE + ++ L NQ L Q
Sbjct: 2553 RRKQEELQQLEQQRRQQEELLAEENQRLREQ 2583
Score = 55.5 bits (132), Expect = 5e-08
Identities = 60/269 (22%), Positives = 114/269 (42%), Gaps = 36/269 (13%)
Query: 10 QAQTQRKQLLEESRE--LHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 67
QA+ + K+L + +E + RE+ V A+ + +E +Q + + +Q
Sbjct: 1371 QAEREAKELQQRMQEEVVRREEAAVDAQQQ------KRSIQEELQQLRQSSEAEIQAKAR 1424
Query: 68 IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE 127
+ S R E+I V++ L E + + +LQA+R A E Q+++ Q E
Sbjct: 1425 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1484
Query: 128 TKKVQAETASKTREVQAQL-----------------LQEKRLLEKQLSEPDRRLLGKRKR 170
++ + + + R+ + +L LQ L Q E +RRL
Sbjct: 1485 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1544
Query: 171 R--------ELNMKAQALKLAAKRFIF-EYSCGINRENQQFKKELLQLIEQAQKLTATQS 221
R E ++ +L +KR F E + + R Q+ + QL E+A++ Q+
Sbjct: 1545 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1604
Query: 222 HLENRKQQLQQ--EQWYLESLIQARQRLQ 248
E +++ ++ E+W L++ R RLQ
Sbjct: 1605 EAERAREEAERELERWQLKANEALRLRLQ 1633
Score = 48.5 bits (114), Expect = 6e-06
Identities = 56/228 (24%), Positives = 106/228 (46%), Gaps = 25/228 (10%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+ AQ RKQ E +LHR +L Q E ++ L + ++ E++ + + E
Sbjct: 2387 EDAQRFRKQAEEIGEKLHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2445
Query: 69 ERRRQES---ASRYAEQISVLKTALLQKENI--QSSLKRKLQAMRDIAILKEKQEKEIQT 123
E+ +QE+ + E +V + LLQ+ QS L K ++ +++++ K Q
Sbjct: 2446 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2505
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRRELNMKAQA 179
Q+E K Q + R+ Q Q+ QE++ L + E RR G R+++E + +
Sbjct: 2506 FQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2564
Query: 180 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ-------AQKLTATQ 220
+ + + E ENQ+ +++L L EQ ++++TA+Q
Sbjct: 2565 QRRQQEELLAE-------ENQRLREQLQLLEEQHRAALAHSEEVTASQ 2605
Score = 46.6 bits (109), Expect = 2e-05
Identities = 58/244 (23%), Positives = 107/244 (43%), Gaps = 29/244 (11%)
Query: 8 IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEYLTNKTEEYT---EQPEKVWNSY 61
++ QR+Q+ EE L EK +AE L + + E+ EQ E
Sbjct: 1899 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1958
Query: 62 LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE- 120
Q + E ERRR+E+ R + ++ + A Q++ ++R + + L+E+ E+E
Sbjct: 1959 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2018
Query: 121 ---IQTLQEET-KKVQAE-------TASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 169
+Q QE K++QAE K +E+Q L QE+ +L++ E + +
Sbjct: 2019 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2078
Query: 170 RRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQ 229
E ++A+ ++R + E ++ K+ EQAQ Q+ E +++
Sbjct: 2079 AEEARVQAEREAAQSRRQV--------EEAERLKQ---SAEEQAQARAQAQAAAEKLRKE 2127
Query: 230 LQQE 233
+QE
Sbjct: 2128 AEQE 2131
Score = 44.3 bits (103), Expect = 1e-04
Identities = 50/247 (20%), Positives = 114/247 (46%), Gaps = 19/247 (7%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYL 62
+ + ++QA+ +R + ++ + E + +AE + KT + ++ +
Sbjct: 1533 EAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSLQEEHVAVA 1590
Query: 63 QKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ 122
Q E ERR Q+ A + + + +L+ +LQA ++A Q+K +
Sbjct: 1591 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA-----QQKSLA 1644
Query: 123 TLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALK 181
+ E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L + + ++
Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIR 1703
Query: 182 LAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLI 241
L A+ E ++ Q ++EL +L +A T + LE +++ E +E L+
Sbjct: 1704 LRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE---MEVLL 1754
Query: 242 QARQRLQ 248
++ R +
Sbjct: 1755 ASKARAE 1761
Score = 41.6 bits (96), Expect = 8e-04
Identities = 47/238 (19%), Positives = 99/238 (41%), Gaps = 8/238 (3%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHR-----EKLLVQAENRFFLEYL-TNKTEEYTEQPEK 56
+L + ++Q Q+ QL E+ R E+ VQAE + E + E+
Sbjct: 2050 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2109
Query: 57 VWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEK 116
+ Q E+ R+E+ A + + AL QK+ + +++ + K +
Sbjct: 2110 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2169
Query: 117 QEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK 176
E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R + E K
Sbjct: 2170 VEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSK 2228
Query: 177 AQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 233
+A ++ + I R Q+ +++ Q+ E+A +L+ +Q +++
Sbjct: 2229 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2286
Score = 40.4 bits (93), Expect = 0.002
Identities = 59/249 (23%), Positives = 108/249 (43%), Gaps = 30/249 (12%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++A QRK LEE + R K V+ R L + E+ + + ++ QK +
Sbjct: 1984 EEAARQRKAALEE---VERLKAKVEEARR-----LRERAEQESARQLQLAQEAAQKRLQA 2035
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
E + A + EQ L+ L Q++++ L+ + +A R A +E +E +Q
Sbjct: 2036 EEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQA----- 2086
Query: 129 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 188
+ E A R+V+ ++ E+ + + ++ R+E +A A + A++
Sbjct: 2087 ---EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA-ARRAQAEQAA 2142
Query: 189 FEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHLE---NRKQQLQQEQWYL--ES 239
+ E ++ KK Q + Q Q+LT + LE ++K L +E L E+
Sbjct: 2143 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2202
Query: 240 LIQARQRLQ 248
ARQR Q
Sbjct: 2203 TEAARQRSQ 2211
Score = 35.8 bits (81), Expect = 0.042
Identities = 40/174 (22%), Positives = 77/174 (44%), Gaps = 13/174 (7%)
Query: 71 RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKK 130
RR E R AEQ + L + ++++L+++ Q A K + E+E + LQ+ +
Sbjct: 1328 RRMEEEERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1384
Query: 131 VQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK-RFIF 189
E + E Q+KR ++++L + L + E+ KA+ + A + R
Sbjct: 1385 ---EEVVRREEAAVDAQQQKRSIQEELQQ-----LRQSSEAEIQAKARQAEAAERSRLRI 1436
Query: 190 EYSCGINR-ENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQ 242
E + R + + +++ + Q L A E +K+Q Q+E L +Q
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1490
Score = 35.4 bits (80), Expect = 0.055
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 6 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 63
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1096 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1155
Query: 64 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 123
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1156 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1211
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 155
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1212 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1243
Score = 35.4 bits (80), Expect = 0.055
Identities = 52/235 (22%), Positives = 100/235 (42%), Gaps = 26/235 (11%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+QA QR +L E+ E R+ A+ R E + TEQ E+ L++ E+
Sbjct: 1667 EQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-RQLLEE--EL 1722
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
R ++E+A+ A +++ +++ L + M + K + E+E ++ E++
Sbjct: 1723 ARLQREAAA-----------ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1771
Query: 129 KKVQAETASKTREV-----QAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK------A 177
K+ A + RE+ + + L E+ ++QL+E D R L K A
Sbjct: 1772 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1831
Query: 178 QALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 232
LK A+ + E R + + E Q ++ ++ +E R QL++
Sbjct: 1832 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1886
Score = 34.7 bits (78), Expect = 0.094
Identities = 48/195 (24%), Positives = 87/195 (44%), Gaps = 28/195 (14%)
Query: 67 EIERRRQ--ESASRYAEQ-ISVLKTALLQKENIQSSL--------KRKLQAMRDIAILKE 115
EIER + E R+A+Q I+ +K LQ ++ L K K+Q+ + I
Sbjct: 1243 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI--- 1299
Query: 116 KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRR 171
++ +++T E + ++ E ++ +E+RL E+Q +E RL K+R
Sbjct: 1300 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1359
Query: 172 ELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+L K A+R E Q+ ++E+++ E A + ++ QQL+
Sbjct: 1360 QLAEAHAQAKAQAEREAKEL-------QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1412
Query: 232 QEQWYLESLIQARQR 246
Q E+ IQA+ R
Sbjct: 1413 QSS---EAEIQAKAR 1424
Score = 30.0 bits (66), Expect = 2.3
Identities = 35/160 (21%), Positives = 63/160 (39%), Gaps = 9/160 (5%)
Query: 81 EQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTR 140
EQ+ L L+K S + R Q ++ E+Q KE Q + +++A AS +
Sbjct: 1061 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1120
Query: 141 -----EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK----RFIFEY 191
E Q R + E RL + R++ ++ ++A + +
Sbjct: 1121 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1180
Query: 192 SCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+ RE +Q ++L E A L A R++Q+Q
Sbjct: 1181 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 60.5 bits (145), Expect = 2e-09
Identities = 67/271 (24%), Positives = 122/271 (45%), Gaps = 32/271 (11%)
Query: 17 QLLEESRELHREKLL-VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIER----- 70
+LL++ +EL +E+ +Q + + L +T+ + E L+ S E ER
Sbjct: 2357 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2416
Query: 71 --------RRQESASRYAEQISVL-----KTALLQKENI---QSSLKRKLQAMRDIAILK 114
R +E A R+ +Q + +T L +E + Q+ ++ Q+ D L+
Sbjct: 2417 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2476
Query: 115 E---KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQ-LSEPDRRLLGKRKR 170
E + E+E + LQ+E K +Q ++ Q QLLQE + L++ LSE D L +R
Sbjct: 2477 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2536
Query: 171 RELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRK 227
+ K + L ++A + + E R+ QQ ++E +L+ ++ Q E
Sbjct: 2537 EQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2593
Query: 228 QQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 258
++ Q+E LE + ++ L NQ L Q
Sbjct: 2594 RRKQEELQQLEQQRRQQEELLAEENQRLREQ 2624
Score = 55.5 bits (132), Expect = 5e-08
Identities = 60/269 (22%), Positives = 114/269 (42%), Gaps = 36/269 (13%)
Query: 10 QAQTQRKQLLEESRE--LHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 67
QA+ + K+L + +E + RE+ V A+ + +E +Q + + +Q
Sbjct: 1412 QAEREAKELQQRMQEEVVRREEAAVDAQQQ------KRSIQEELQQLRQSSEAEIQAKAR 1465
Query: 68 IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE 127
+ S R E+I V++ L E + + +LQA+R A E Q+++ Q E
Sbjct: 1466 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1525
Query: 128 TKKVQAETASKTREVQAQL-----------------LQEKRLLEKQLSEPDRRLLGKRKR 170
++ + + + R+ + +L LQ L Q E +RRL
Sbjct: 1526 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1585
Query: 171 R--------ELNMKAQALKLAAKRFIF-EYSCGINRENQQFKKELLQLIEQAQKLTATQS 221
R E ++ +L +KR F E + + R Q+ + QL E+A++ Q+
Sbjct: 1586 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1645
Query: 222 HLENRKQQLQQ--EQWYLESLIQARQRLQ 248
E +++ ++ E+W L++ R RLQ
Sbjct: 1646 EAERAREEAERELERWQLKANEALRLRLQ 1674
Score = 48.5 bits (114), Expect = 6e-06
Identities = 56/228 (24%), Positives = 106/228 (46%), Gaps = 25/228 (10%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+ AQ RKQ E +LHR +L Q E ++ L + ++ E++ + + E
Sbjct: 2428 EDAQRFRKQAEEIGEKLHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2486
Query: 69 ERRRQES---ASRYAEQISVLKTALLQKENI--QSSLKRKLQAMRDIAILKEKQEKEIQT 123
E+ +QE+ + E +V + LLQ+ QS L K ++ +++++ K Q
Sbjct: 2487 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2546
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRRELNMKAQA 179
Q+E K Q + R+ Q Q+ QE++ L + E RR G R+++E + +
Sbjct: 2547 FQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2605
Query: 180 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ-------AQKLTATQ 220
+ + + E ENQ+ +++L L EQ ++++TA+Q
Sbjct: 2606 QRRQQEELLAE-------ENQRLREQLQLLEEQHRAALAHSEEVTASQ 2646
Score = 46.6 bits (109), Expect = 2e-05
Identities = 58/244 (23%), Positives = 107/244 (43%), Gaps = 29/244 (11%)
Query: 8 IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEYLTNKTEEYT---EQPEKVWNSY 61
++ QR+Q+ EE L EK +AE L + + E+ EQ E
Sbjct: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1999
Query: 62 LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE- 120
Q + E ERRR+E+ R + ++ + A Q++ ++R + + L+E+ E+E
Sbjct: 2000 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2059
Query: 121 ---IQTLQEET-KKVQAE-------TASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 169
+Q QE K++QAE K +E+Q L QE+ +L++ E + +
Sbjct: 2060 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2119
Query: 170 RRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQ 229
E ++A+ ++R + E ++ K+ EQAQ Q+ E +++
Sbjct: 2120 AEEARVQAEREAAQSRRQV--------EEAERLKQ---SAEEQAQARAQAQAAAEKLRKE 2168
Query: 230 LQQE 233
+QE
Sbjct: 2169 AEQE 2172
Score = 44.3 bits (103), Expect = 1e-04
Identities = 50/247 (20%), Positives = 114/247 (46%), Gaps = 19/247 (7%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYL 62
+ + ++QA+ +R + ++ + E + +AE + KT + ++ +
Sbjct: 1574 EAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSLQEEHVAVA 1631
Query: 63 QKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ 122
Q E ERR Q+ A + + + +L+ +LQA ++A Q+K +
Sbjct: 1632 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA-----QQKSLA 1685
Query: 123 TLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALK 181
+ E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L + + ++
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIR 1744
Query: 182 LAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLI 241
L A+ E ++ Q ++EL +L +A T + LE +++ E +E L+
Sbjct: 1745 LRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE---MEVLL 1795
Query: 242 QARQRLQ 248
++ R +
Sbjct: 1796 ASKARAE 1802
Score = 41.6 bits (96), Expect = 8e-04
Identities = 47/238 (19%), Positives = 99/238 (41%), Gaps = 8/238 (3%)
Query: 3 DLNKHIKQAQTQRKQLLEESRELHR-----EKLLVQAENRFFLEYL-TNKTEEYTEQPEK 56
+L + ++Q Q+ QL E+ R E+ VQAE + E + E+
Sbjct: 2091 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150
Query: 57 VWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEK 116
+ Q E+ R+E+ A + + AL QK+ + +++ + K +
Sbjct: 2151 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2210
Query: 117 QEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK 176
E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R + E K
Sbjct: 2211 VEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSK 2269
Query: 177 AQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 233
+A ++ + I R Q+ +++ Q+ E+A +L+ +Q +++
Sbjct: 2270 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2327
Score = 40.4 bits (93), Expect = 0.002
Identities = 59/249 (23%), Positives = 108/249 (43%), Gaps = 30/249 (12%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++A QRK LEE + R K V+ R L + E+ + + ++ QK +
Sbjct: 2025 EEAARQRKAALEE---VERLKAKVEEARR-----LRERAEQESARQLQLAQEAAQKRLQA 2076
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
E + A + EQ L+ L Q++++ L+ + +A R A +E +E +Q
Sbjct: 2077 EEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQA----- 2127
Query: 129 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 188
+ E A R+V+ ++ E+ + + ++ R+E +A A + A++
Sbjct: 2128 ---EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA-ARRAQAEQAA 2183
Query: 189 FEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHLE---NRKQQLQQEQWYL--ES 239
+ E ++ KK Q + Q Q+LT + LE ++K L +E L E+
Sbjct: 2184 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2243
Query: 240 LIQARQRLQ 248
ARQR Q
Sbjct: 2244 TEAARQRSQ 2252
Score = 35.8 bits (81), Expect = 0.042
Identities = 40/174 (22%), Positives = 77/174 (44%), Gaps = 13/174 (7%)
Query: 71 RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKK 130
RR E R AEQ + L + ++++L+++ Q A K + E+E + LQ+ +
Sbjct: 1369 RRMEEEERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1425
Query: 131 VQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK-RFIF 189
E + E Q+KR ++++L + L + E+ KA+ + A + R
Sbjct: 1426 ---EEVVRREEAAVDAQQQKRSIQEELQQ-----LRQSSEAEIQAKARQAEAAERSRLRI 1477
Query: 190 EYSCGINR-ENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQ 242
E + R + + +++ + Q L A E +K+Q Q+E L +Q
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1531
Score = 35.4 bits (80), Expect = 0.055
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 6 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 63
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1137 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1196
Query: 64 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 123
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1197 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1252
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 155
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1253 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1284
Score = 35.4 bits (80), Expect = 0.055
Identities = 52/235 (22%), Positives = 100/235 (42%), Gaps = 26/235 (11%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+QA QR +L E+ E R+ A+ R E + TEQ E+ L++ E+
Sbjct: 1708 EQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-RQLLEE--EL 1763
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
R ++E+A+ A +++ +++ L + M + K + E+E ++ E++
Sbjct: 1764 ARLQREAAA-----------ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1812
Query: 129 KKVQAETASKTREV-----QAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK------A 177
K+ A + RE+ + + L E+ ++QL+E D R L K A
Sbjct: 1813 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1872
Query: 178 QALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 232
LK A+ + E R + + E Q ++ ++ +E R QL++
Sbjct: 1873 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1927
Score = 34.7 bits (78), Expect = 0.094
Identities = 48/195 (24%), Positives = 87/195 (44%), Gaps = 28/195 (14%)
Query: 67 EIERRRQ--ESASRYAEQ-ISVLKTALLQKENIQSSL--------KRKLQAMRDIAILKE 115
EIER + E R+A+Q I+ +K LQ ++ L K K+Q+ + I
Sbjct: 1284 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI--- 1340
Query: 116 KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL----LGKRKRR 171
++ +++T E + ++ E ++ +E+RL E+Q +E RL K+R
Sbjct: 1341 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1400
Query: 172 ELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+L K A+R E Q+ ++E+++ E A + ++ QQL+
Sbjct: 1401 QLAEAHAQAKAQAEREAKEL-------QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1453
Query: 232 QEQWYLESLIQARQR 246
Q E+ IQA+ R
Sbjct: 1454 QSS---EAEIQAKAR 1465
Score = 30.0 bits (66), Expect = 2.3
Identities = 35/160 (21%), Positives = 63/160 (39%), Gaps = 9/160 (5%)
Query: 81 EQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTR 140
EQ+ L L+K S + R Q ++ E+Q KE Q + +++A AS +
Sbjct: 1102 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1161
Query: 141 -----EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK----RFIFEY 191
E Q R + E RL + R++ ++ ++A + +
Sbjct: 1162 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1221
Query: 192 SCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+ RE +Q ++L E A L A R++Q+Q
Sbjct: 1222 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1261
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 60.1 bits (144), Expect = 2e-09
Identities = 56/239 (23%), Positives = 115/239 (48%), Gaps = 22/239 (9%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++A+ R+Q +EE + E++ ++ E R L + E + E+ QK +I
Sbjct: 549 EEAEQLRRQKVEEDKRRRLEEVKLKREER--LRKVLQARERVEQMKEEKKKQIEQKFAQI 606
Query: 69 ERRRQESAS-RYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE 127
+ + +++ R AE+ + K A + E +++ K++ +A R + +E++E+ Q L ++
Sbjct: 607 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 666
Query: 128 TKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLA---- 183
K+ + E K E A+ L E+R E++ E + +++RRE + Q +LA
Sbjct: 667 KKEEEQERLRKAAE--AKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER 724
Query: 184 --------AKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQ 234
A+R + E + + +Q ++EL + +K Q L R+ Q +QE+
Sbjct: 725 RREQERLQAERELQEREKALRLQKEQLQREL-----EEKKKKEEQQRLAERQLQEEQEK 778
Score = 52.4 bits (124), Expect = 4e-07
Identities = 58/206 (28%), Positives = 96/206 (46%), Gaps = 18/206 (8%)
Query: 63 QKSGEIERRRQESASRYAEQISVLKTALLQKENI-QSSLKRKLQAMRDIAILKEKQEKEI 121
QK E +RRR E E+ L+ L +E + Q ++K Q + A + EK EK
Sbjct: 557 QKVEEDKRRRLEEVKLKREER--LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614
Query: 122 QTLQEETKKVQAETASKTREVQAQLLQE---KRLLEKQLSEPDRR---LLGKRKRRE--- 172
+ E K + A K EV+A+ QE +RL Q E +RR LL K+K E
Sbjct: 615 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER 674
Query: 173 LNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 232
L A+A +LA +R E RE ++ ++E + + Q+ + L ++++ +Q
Sbjct: 675 LRKAAEAKRLAEQR---EQE---RREQERREQERREQERREQERREQERQLAEQERRREQ 728
Query: 233 EQWYLESLIQARQRLQGSHNQCLNRQ 258
E+ E +Q R++ + L R+
Sbjct: 729 ERLQAERELQEREKALRLQKEQLQRE 754
Score = 46.6 bits (109), Expect = 2e-05
Identities = 55/230 (23%), Positives = 104/230 (45%), Gaps = 31/230 (13%)
Query: 8 IKQAQTQRKQLLEESR-ELHREKLLVQAENRFF-LEYLTNKTEEYTEQPEKVWN-SYLQK 64
+K+ + RK L R E +E+ Q E +F ++ T K +E EK + +K
Sbjct: 572 LKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKK 631
Query: 65 SGEIE-RRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKE-----KQE 118
E+E RR+QE +R + + +E +Q + + + +R A K +QE
Sbjct: 632 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE 691
Query: 119 KEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQ 178
+ Q +E+ ++ Q + RE + QL +++R E++ + + REL + +
Sbjct: 692 RREQERREQERREQERREQERREQERQLAEQERRREQERLQAE---------RELQEREK 742
Query: 179 ALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 228
AL+L ++ + RE ++ KK+ E+ Q+L Q E K+
Sbjct: 743 ALRLQKEQ--------LQRELEEKKKK-----EEQQRLAERQLQEEQEKK 779
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 60.1 bits (144), Expect = 2e-09
Identities = 56/239 (23%), Positives = 115/239 (48%), Gaps = 22/239 (9%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++A+ R+Q +EE + E++ ++ E R L + E + E+ QK +I
Sbjct: 545 EEAEQLRRQKVEEDKRRRLEEVKLKREER--LRKVLQARERVEQMKEEKKKQIEQKFAQI 602
Query: 69 ERRRQESAS-RYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE 127
+ + +++ R AE+ + K A + E +++ K++ +A R + +E++E+ Q L ++
Sbjct: 603 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 662
Query: 128 TKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLA---- 183
K+ + E K E A+ L E+R E++ E + +++RRE + Q +LA
Sbjct: 663 KKEEEQERLRKAAE--AKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER 720
Query: 184 --------AKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQ 234
A+R + E + + +Q ++EL + +K Q L R+ Q +QE+
Sbjct: 721 RREQERLQAERELQEREKALRLQKEQLQREL-----EEKKKKEEQQRLAERQLQEEQEK 774
Score = 52.4 bits (124), Expect = 4e-07
Identities = 58/206 (28%), Positives = 96/206 (46%), Gaps = 18/206 (8%)
Query: 63 QKSGEIERRRQESASRYAEQISVLKTALLQKENI-QSSLKRKLQAMRDIAILKEKQEKEI 121
QK E +RRR E E+ L+ L +E + Q ++K Q + A + EK EK
Sbjct: 553 QKVEEDKRRRLEEVKLKREER--LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 610
Query: 122 QTLQEETKKVQAETASKTREVQAQLLQE---KRLLEKQLSEPDRR---LLGKRKRRE--- 172
+ E K + A K EV+A+ QE +RL Q E +RR LL K+K E
Sbjct: 611 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER 670
Query: 173 LNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 232
L A+A +LA +R E RE ++ ++E + + Q+ + L ++++ +Q
Sbjct: 671 LRKAAEAKRLAEQR---EQE---RREQERREQERREQERREQERREQERQLAEQERRREQ 724
Query: 233 EQWYLESLIQARQRLQGSHNQCLNRQ 258
E+ E +Q R++ + L R+
Sbjct: 725 ERLQAERELQEREKALRLQKEQLQRE 750
Score = 46.6 bits (109), Expect = 2e-05
Identities = 55/230 (23%), Positives = 104/230 (45%), Gaps = 31/230 (13%)
Query: 8 IKQAQTQRKQLLEESR-ELHREKLLVQAENRFF-LEYLTNKTEEYTEQPEKVWN-SYLQK 64
+K+ + RK L R E +E+ Q E +F ++ T K +E EK + +K
Sbjct: 568 LKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKK 627
Query: 65 SGEIE-RRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKE-----KQE 118
E+E RR+QE +R + + +E +Q + + + +R A K +QE
Sbjct: 628 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE 687
Query: 119 KEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQ 178
+ Q +E+ ++ Q + RE + QL +++R E++ + + REL + +
Sbjct: 688 RREQERREQERREQERREQERREQERQLAEQERRREQERLQAE---------RELQEREK 738
Query: 179 ALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 228
AL+L ++ + RE ++ KK+ E+ Q+L Q E K+
Sbjct: 739 ALRLQKEQ--------LQRELEEKKKK-----EEQQRLAERQLQEEQEKK 775
Score = 30.4 bits (67), Expect = 1.8
Identities = 39/189 (20%), Positives = 84/189 (44%), Gaps = 18/189 (9%)
Query: 84 SVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTRE-- 141
SV+K+ + + ++ K K + + KE+ E+ + EE K+ + E RE
Sbjct: 514 SVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREER 573
Query: 142 ----------VQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEY 191
V+ ++K+ +E++ ++ D + ++ + E + +A K AA + + E
Sbjct: 574 LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT--EKAKEERLAEEKAKKKAAAKKMEEV 631
Query: 192 SCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE-QWYLESLIQARQRLQGS 250
R Q+ + L+ ++Q ++ Q L+ +K++ Q+ + E+ A QR Q
Sbjct: 632 EA---RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 688
Query: 251 HNQCLNRQD 259
Q Q+
Sbjct: 689 REQERREQE 697
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 59.3 bits (142), Expect = 4e-09
Identities = 67/272 (24%), Positives = 130/272 (47%), Gaps = 32/272 (11%)
Query: 9 KQAQTQRKQLLEESRELHREKLL--VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSG 66
++ Q +R+Q L ++L RE+ L Q E R ++ + E+ ++ ++ +L++
Sbjct: 403 REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREE 462
Query: 67 EIER----RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ 122
E ER RR++ R E+ + L++E + +R+ Q +R +E++E+ Q
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR-----REQEERREQ 517
Query: 123 TL--QEETKKVQAETASKTR------EVQAQLL---QEKRLLEKQLSEPDRRLLGKRKRR 171
L QEE +++Q S+ + E + QLL +EKRL +++ + +R +R+ +
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577
Query: 172 ELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQA----QKLTATQSHLENRK 227
L + + + KR E R Q+ K+E ++ +EQ Q+L + E R+
Sbjct: 578 LLKREEERRQQRLKREQEE------RLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631
Query: 228 QQLQQEQWYLESLIQARQRLQGSHNQCLNRQD 259
Q L+ E+ Q R+ Q Q L R++
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREE 663
Score = 58.2 bits (139), Expect = 8e-09
Identities = 70/251 (27%), Positives = 117/251 (46%), Gaps = 28/251 (11%)
Query: 10 QAQTQRKQLLEESRELHREKLLVQAE--NRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 67
+ Q +R++LLE R+ EK + E +R F E + E+ + E V +K E
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQE----EEEKEWRKRETVLRKEEEKLQE 262
Query: 68 IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE 127
E +RQ EQ+ L+ L++E + +++ Q +R L+ KQE+E + QEE
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEE--EQQQQRLRREQQLRRKQEEERREQQEE 320
Query: 128 TKKVQ--AETASKTREVQAQLLQEKRLLEKQL---SEPDRRLLGKRKRRELNMKAQALKL 182
++ Q E + RE Q + QE+R E+QL E +RR R+ +E + Q L+
Sbjct: 321 RREQQERREQQEERREQQLRREQEER-REQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 183 AAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQ 242
+ R QQ ++E Q + + Q+L Q R+QQL++EQ
Sbjct: 380 EQQL----------RREQQLRRE--QQLRREQQLRREQQ--LRREQQLRREQQLRREQQL 425
Query: 243 ARQRLQGSHNQ 253
R++ + H Q
Sbjct: 426 RREQEEERHEQ 436
Score = 57.8 bits (138), Expect = 1e-08
Identities = 71/274 (25%), Positives = 129/274 (47%), Gaps = 28/274 (10%)
Query: 9 KQAQTQRKQL-----LEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 63
+++Q QR+ LEE R+ R L + + E L + + E+ E+ LQ
Sbjct: 863 RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ---EQLRKEQQLLQEEEEE-----LQ 914
Query: 64 KSGEIERRRQESASRYAE--QISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEI 121
+ +RRRQE +Y E Q+ + LL++E + +R+ + R K+ Q+KE
Sbjct: 915 REEREKRRRQEQERQYREEEQLQQEEEQLLREEREK---RRRQERERQYRKDKKLQQKEE 971
Query: 122 QTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK---RKRRELNMKAQ 178
Q L EE +K + + K + +L QE+ L ++ E RR + RK+ EL + +
Sbjct: 972 QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEE 1031
Query: 179 AL--KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLE---NRKQQLQQE 233
L + KR + E RE ++ ++E QL+ + ++ T + LE ++++LQQE
Sbjct: 1032 QLLREEREKRRLQERERQY-REEEELQQEEEQLLGE-ERETRRRQELERQYRKEEELQQE 1089
Query: 234 QWYLESLIQARQRLQGSHNQCLNRQDVPKTTPSL 267
+ L ++R Q QC +++ + L
Sbjct: 1090 EEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123
Score = 53.9 bits (128), Expect = 2e-07
Identities = 60/266 (22%), Positives = 117/266 (43%), Gaps = 44/266 (16%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+ Q +RKQ L+ +E R + ++ E E + ++ + E+ L++ E
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525
Query: 69 ERRRQ----------ESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQE 118
ER +Q E R + + + L++E + LKR+ + RD +LK ++E
Sbjct: 526 ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRD-QLLKREEE 584
Query: 119 KEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQ 178
+ Q L+ E ++ + E K EV+ +E+R + EP+ +RR+ +K++
Sbjct: 585 RRQQRLKREQEE-RLEQRLKREEVERLEQEERREQRLKREEPE------EERRQQLLKSE 637
Query: 179 ALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKL---TATQSHLENRKQQLQQE-- 233
+ ++ + RE Q+ +++ L+ E+ ++L + E R+Q+L +E
Sbjct: 638 EQEERRQQ-------QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 234 --------------QWYLESLIQARQ 245
QW LES ARQ
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQ 716
Score = 53.9 bits (128), Expect = 2e-07
Identities = 61/282 (21%), Positives = 132/282 (46%), Gaps = 34/282 (12%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLE-----YLTNKTEEYTEQPEKVWNSYLQ 63
+Q + QR EE +E R + + + FLE + ++ E+ + + +
Sbjct: 803 RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862
Query: 64 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 123
+ + +RR Q+ + E+ + L K +Q L+++ Q +++ +++E+E +
Sbjct: 863 RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRR 922
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKR------------LLEKQLSEPDRRLLG----K 167
QE+ ++ + E + ++ + QLL+E+R +K+L + + +LLG K
Sbjct: 923 RQEQERQYREE--EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980
Query: 168 RKRRELNMK---AQALKLAAKRFIFEYSCGINRE--NQQFKK--ELLQLIEQAQKLTATQ 220
R+R+E K + L+ ++ + E R+ +Q++K EL Q EQ + +
Sbjct: 981 RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK 1040
Query: 221 SHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPK 262
L+ R++Q ++E E L Q ++L G + RQ++ +
Sbjct: 1041 RRLQERERQYREE----EELQQEEEQLLGEERETRRRQELER 1078
Score = 50.1 bits (118), Expect = 2e-06
Identities = 64/246 (26%), Positives = 106/246 (43%), Gaps = 38/246 (15%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++ Q + +QLL E RE R R LE K EE ++ E++ +K
Sbjct: 1054 EELQQEEEQLLGEERETRR---------RQELERQYRKEEELQQEEEQLLREEPEKRRRQ 1104
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
ER RQ R E++ + LL++E + +R+ + R +E Q++E Q L+EE
Sbjct: 1105 ERERQ---CREEEELQQEEEQLLREEREK---RRRQELERQYREEEEVQQEEEQLLREEP 1158
Query: 129 KKVQAETASKTREVQAQLLQEKRLL------------EKQLSEPDRRLLGKRKRR----- 171
+K + + + + +L QE+ L E+Q E + KRK+R
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218
Query: 172 ---ELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 228
+L + + K A R Y G REN+QF++ + Q Q HL +Q
Sbjct: 1219 QRSDLKWQWEPEKENAVRDNKVYCKG--RENEQFRQLEDSQLRDRQSQQDLQ-HLLGEQQ 1275
Query: 229 QLQQEQ 234
+ +EQ
Sbjct: 1276 ERDREQ 1281
Score = 49.3 bits (116), Expect = 4e-06
Identities = 55/235 (23%), Positives = 107/235 (45%), Gaps = 10/235 (4%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++ + +R QLL+ E +++L + E R + L + E EQ E+ ++ E
Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERLE-QRLKREEVERLEQEERREQRLKREEPEE 627
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK---EKQEKEIQTLQ 125
ERR+Q S E+ + Q+E + LKR+ + R LK E++ +E + +
Sbjct: 628 ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687
Query: 126 EETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK 185
EE ++ + S+ + Q QL E + ++ R+ G+R+R+E K + + +
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747
Query: 186 RFIFEYSCGINRENQQFKKELLQLIEQ------AQKLTATQSHLENRKQQLQQEQ 234
E + +E +Q + Q + Q+L+A E R++QL+ E+
Sbjct: 748 WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE 802
Score = 48.9 bits (115), Expect = 5e-06
Identities = 57/263 (21%), Positives = 122/263 (46%), Gaps = 37/263 (14%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYT--EQPEKVWNSYLQKSG 66
+Q Q + +QLL E RE R + + E ++ + + EE E+PEK
Sbjct: 934 EQLQQEEEQLLREEREKRRRQ---ERERQYRKDKKLQQKEEQLLGEEPEK---------- 980
Query: 67 EIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQE 126
RRRQE +Y E+ LQ+E Q + + + R + +++ E+Q QE
Sbjct: 981 ---RRRQEREKKYREEEE------LQQEEEQLLREEREKRRRQEWERQYRKKDELQ--QE 1029
Query: 127 ETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK----RKRRELN---MKAQA 179
E + ++ E + + + + +E E++L + + +LLG+ R+R+EL K +
Sbjct: 1030 EEQLLREEREKRRLQERERQYRE----EEELQQEEEQLLGEERETRRRQELERQYRKEEE 1085
Query: 180 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLES 239
L+ ++ + E R+ ++ + + ++Q ++ + + R+Q+L+++ E
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEE 1145
Query: 240 LIQARQRLQGSHNQCLNRQDVPK 262
+ Q ++L + RQ++ +
Sbjct: 1146 VQQEEEQLLREEPEKRRRQELER 1168
Score = 48.5 bits (114), Expect = 6e-06
Identities = 55/234 (23%), Positives = 110/234 (47%), Gaps = 16/234 (6%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
K+ + +++ + REL E+ ++ R E + EE +Q L++ E
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLER--QELRRERQEEEQQQQRLRREQQLRRKQEE 312
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE-----IQT 123
ERR Q+ R ++ Q+E + L+R+ + R+ + +E QE+E ++
Sbjct: 313 ERREQQEERREQQE-----RREQQEERREQQLRREQEERREQQLRRE-QEEERREQQLRR 366
Query: 124 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK-RRELNM-KAQALK 181
QEE ++ Q + + QL +E++L +Q +++L +++ RRE + + Q L+
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 182 LAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSH-LENRKQQLQQEQ 234
+ E R Q+ K+E + + ++ T+ H E RKQQL+++Q
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ 480
Score = 48.1 bits (113), Expect = 8e-06
Identities = 54/254 (21%), Positives = 114/254 (44%), Gaps = 42/254 (16%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++ Q Q ++L E + +++ L Q + + E L + +E+ E+ E+ + ++
Sbjct: 139 QKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREER-----RAEEEQL 193
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ----TL 124
+ + + ++ + + LL+ K++ + R + +E++EKE + L
Sbjct: 194 QSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL 253
Query: 125 QEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAA 184
++E +K+Q E + RE+Q + E+QL + +R+ L +R+R+E + Q L+
Sbjct: 254 RKEEEKLQEEEPQRQRELQEE--------EEQLRKLERQEL-RRERQEEEQQQQRLR--- 301
Query: 185 KRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQAR 244
RE Q +K+ + EQ + E R+QQ ++EQ Q R
Sbjct: 302 ------------REQQLRRKQEEERREQQE---------ERREQQERREQQEERREQQLR 340
Query: 245 QRLQGSHNQCLNRQ 258
+ + Q L R+
Sbjct: 341 REQEERREQQLRRE 354
Score = 48.1 bits (113), Expect = 8e-06
Identities = 56/249 (22%), Positives = 106/249 (42%), Gaps = 45/249 (18%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
KQ +R+Q EE R +L Q E R + +E ++ + W ++ E
Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAH-----RQQQEEEQRRDFTWQWQAEEKSER 779
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
R+R + EQ +R+L+A +E+Q++E + L EE
Sbjct: 780 GRQRLSARPPLREQ-----------------RERQLRA-------EERQQREQRFLPEEE 815
Query: 129 KKVQAETASKTREVQAQLLQEKRLLEKQ------------LSEPDRRLLGKRKRRELNMK 176
+K Q + RE + Q L+E+ L+++ L E R + +RR+ +
Sbjct: 816 EKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR 875
Query: 177 AQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWY 236
Q + +R Y+ +E + +++LLQ E+ ++L + E R++Q Q+ Q+
Sbjct: 876 WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ--EEEEEL--QREEREKRRRQEQERQYR 931
Query: 237 LESLIQARQ 245
E +Q +
Sbjct: 932 EEEQLQQEE 940
Score = 48.1 bits (113), Expect = 8e-06
Identities = 53/241 (21%), Positives = 112/241 (46%), Gaps = 23/241 (9%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++ Q + +QLL E RE R + + E ++ K +E ++ E++ +K
Sbjct: 994 EELQQEEEQLLREEREKRRRQ---EWERQY------RKKDELQQEEEQLLREEREKRRLQ 1044
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE- 127
ER RQ R E++ + LL +E +R+ + R +E Q++E Q L+EE
Sbjct: 1045 ERERQY---REEEELQQEEEQLLGEER---ETRRRQELERQYRKEEELQQEEEQLLREEP 1098
Query: 128 TKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRF 187
K+ + E + RE + +E++LL ++ + R+ L ++ R E ++ + +L +
Sbjct: 1099 EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREE- 1157
Query: 188 IFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRL 247
R Q+ +++ + E Q+ + +++Q ++ Q+ E +Q ++R
Sbjct: 1158 ------PEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211
Query: 248 Q 248
Q
Sbjct: 1212 Q 1212
Score = 48.1 bits (113), Expect = 8e-06
Identities = 60/258 (23%), Positives = 116/258 (44%), Gaps = 27/258 (10%)
Query: 9 KQAQTQRKQLLEESRELHRE--KLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSY----- 61
+Q+Q + LL E +E RE + Q +R F E + EE E + S
Sbjct: 1261 RQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL 1320
Query: 62 LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEI 121
L++ E +RRRQE+ ++ E+ +L+ +R+ Q +R ++ +E+E+
Sbjct: 1321 LREEREEKRRRQETDRKFREEEQLLQ-------------EREEQPLRRQERDRKFREEEL 1367
Query: 122 QTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALK 181
+ ++ K ++ E + +E + + L+E++ L Q E +++L R R+ + Q +
Sbjct: 1368 RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQ--EREQQLRQDRDRKFREEEQQLSR 1425
Query: 182 LAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLI 241
R E + R+ ++ K +E+ Q+L + ++QL QE+ +
Sbjct: 1426 QERDRKFREEEQQVRRQERERK-----FLEEEQQLRQERHRKFREEEQLLQEREEQQLHR 1480
Query: 242 QARQRLQGSHNQCLNRQD 259
Q R R Q L RQ+
Sbjct: 1481 QERDRKFLEEEQQLRRQE 1498
Score = 47.0 bits (110), Expect = 2e-05
Identities = 62/269 (23%), Positives = 122/269 (45%), Gaps = 24/269 (8%)
Query: 6 KHIKQAQTQRKQLLEES--RELHREKLLVQAENRFFLEY-----LTNKTEEYTEQPEKVW 58
+ +++ + +RK L EE R RE+ L Q +R F E + ++ E+ ++V
Sbjct: 1381 QRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVR 1440
Query: 59 NSYLQKS--GEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKL---QAMRDIAIL 113
++ E ++ RQE ++ E+ +L+ Q+ + Q ++ L Q +R
Sbjct: 1441 RQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERD 1500
Query: 114 KEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRE- 172
++ +E+E+++ + E K ++ E ++ Q + LQE++ L +Q RR RK RE
Sbjct: 1501 RKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE 1560
Query: 173 --LNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQL 230
L + + +L+ + E E Q+ +++ EQ +K + L ++ Q
Sbjct: 1561 EQLRQEREEQQLSRQ----ERDRKFRLEEQKVRRQ-----EQERKFMEDEQQLRRQEGQQ 1611
Query: 231 QQEQWYLESLIQARQRLQGSHNQCLNRQD 259
Q Q + Q LQ Q L+RQ+
Sbjct: 1612 QLRQERDRKFREDEQLLQEREEQQLHRQE 1640
Score = 46.2 bits (108), Expect = 3e-05
Identities = 57/263 (21%), Positives = 112/263 (42%), Gaps = 29/263 (11%)
Query: 6 KHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKS 65
K +++ Q R+Q E R+ ++L Q R FLE EE ++ +LQ+
Sbjct: 1486 KFLEEEQQLRRQ--ERDRKFREQELRSQEPERKFLE------EEQQLHRQQRQRKFLQEE 1537
Query: 66 GEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQ----AMRDIAILKEKQEKEI 121
++ R+ + R + L++E + L R+ + + + + +++QE++
Sbjct: 1538 QQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKF 1597
Query: 122 QT------LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNM 175
QE ++++ E K RE + QLLQE+ + E DR+ L + +
Sbjct: 1598 MEDEQQLRRQEGQQQLRQERDRKFREDE-QLLQEREEQQLHRQERDRKFLEEEPQLRRQE 1656
Query: 176 KAQALKLAAKRFIFEYSCGINRENQQ----------FKKELLQLIEQAQKLTATQSHLEN 225
+ Q L+ R E + +Q F++E QL Q ++ Q +
Sbjct: 1657 REQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQL 1716
Query: 226 RKQQLQQEQWYLESLIQARQRLQ 248
R+Q+L+++ E L Q ++ Q
Sbjct: 1717 RRQELERKFREEEQLRQETEQEQ 1739
Score = 45.8 bits (107), Expect = 4e-05
Identities = 57/241 (23%), Positives = 109/241 (45%), Gaps = 31/241 (12%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
++ + ++++ E+ E ++L + E R + + EE EQ L++ E
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQ-------QLRREQEE 370
Query: 69 ERR----RQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTL 124
ERR R+E R +Q+ + L++E L+R+ Q R+ + +E+Q + Q L
Sbjct: 371 ERREQQLRREQQLRREQQLR--REQQLRRE---QQLRREQQLRREQQLRREQQLRREQQL 425
Query: 125 QEETKKVQAETASKTREVQAQLLQE--------KRLLEKQLSEPDRRLLGKRKRRELNMK 176
+ E ++ + E + + +L +E KR E + E +RR ++ +E +
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR 485
Query: 177 AQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENR---KQQLQQE 233
+ LKL + E R QQ ++E + EQ K + L+ R +QQL++E
Sbjct: 486 ERWLKLEEE----ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE 541
Query: 234 Q 234
Q
Sbjct: 542 Q 542
Score = 45.8 bits (107), Expect = 4e-05
Identities = 52/254 (20%), Positives = 115/254 (45%), Gaps = 22/254 (8%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+Q + + +QL E E RE+ L + + E + ++ + + L++ ++
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401
Query: 69 ERRRQ---ESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQ 125
R +Q E R +Q+ + L++E + ++K + R LK +QE+ L+
Sbjct: 402 RREQQLRREQQLRREQQLR--REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459
Query: 126 EETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK 185
E + + E + ++++ +E+R +L E +RR +++RRE ++ + + +
Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE--QQERREQQLRREQEERREQ 517
Query: 186 RFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQ 245
R + Q+ ++ L Q + Q+L Q E R+Q L++E+ E ++ +
Sbjct: 518 RL----------KRQEEEERLQQRLRSEQQLRREQE--ERREQLLKREE---EKRLEQER 562
Query: 246 RLQGSHNQCLNRQD 259
R Q + R+D
Sbjct: 563 REQRLKREQEERRD 576
Score = 40.4 bits (93), Expect = 0.002
Identities = 57/256 (22%), Positives = 113/256 (44%), Gaps = 45/256 (17%)
Query: 14 QRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQ 73
+ +QLL+E E ++L Q +R F E EE + ++ +LQ+ ++ R+
Sbjct: 1671 EEEQLLQEGEE---QQLRRQERDRKFRE------EEQQLRRQERERKFLQEEQQLRRQEL 1721
Query: 74 ESASRYAEQI----------------SVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQ 117
E R EQ+ +L+ L+ E + L+R+ RD K ++
Sbjct: 1722 ERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQ---ERD---RKFRE 1775
Query: 118 EKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKA 177
E++++ +EE + E+ K RE + QL QE+ E+QL R + + +L ++
Sbjct: 1776 EEQLRQEREEQQLRSQESDRKFRE-EEQLRQERE--EQQLRPQQRDGKYRWEEEQLQLEE 1832
Query: 178 QALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYL 237
Q +L + R+ Q +E E++++ E +K++ ++E+
Sbjct: 1833 QEQRLRQE-----------RDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLR 1881
Query: 238 ESLIQARQRLQGSHNQ 253
E I+ +Q+ + H Q
Sbjct: 1882 EEHIRRQQKEEQRHRQ 1897
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 58.2 bits (139), Expect = 8e-09
Identities = 65/286 (22%), Positives = 124/286 (43%), Gaps = 52/286 (18%)
Query: 6 KHIKQA-QTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKV--WNSYL 62
+H++Q Q +QL ++ ++ +++AE + + E E E+ W S
Sbjct: 516 EHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMF 575
Query: 63 QKSGE-----------IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIA 111
QK+ E + ++E E+I VL+ L Q + R +
Sbjct: 576 QKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQA-------RASAGDTRQVE 628
Query: 112 ILKEKQEKEIQTLQEETKKVQAETAS-------KTREVQAQL------------LQEKRL 152
+LK KE+ QEE K++QAE S + RE++ QL L+E+ L
Sbjct: 629 VLK----KELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNL 684
Query: 153 LEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSC-GINRENQQFKKELLQLIE 211
++ + R+ + + ++ +A+A L +R E + EN +F++ +L L +
Sbjct: 685 QLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQ 744
Query: 212 QAQKL-------TATQSHLENRKQQLQQEQWYLESLIQARQRLQGS 250
Q ++ A ++ L ++ Q+L+ E+ LE + A Q +GS
Sbjct: 745 QLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGS 790
Score = 49.7 bits (117), Expect = 3e-06
Identities = 59/242 (24%), Positives = 104/242 (42%), Gaps = 30/242 (12%)
Query: 40 LEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 99
+E L K +E ++ +K+ S + ++E + +E SR E + K Q +
Sbjct: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEE-CSRLQELLERRKGEAQQSNKELQN 426
Query: 100 LKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASK---------TREVQAQLLQEK 150
+KR L D L+ E ++ LQ + K VQ +K TRE+ ++L+ K
Sbjct: 427 MKRLLDQGED---LRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGK 483
Query: 151 RLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLI 210
+ +E+QL + + REL ALK A K + + QQ++++ QL
Sbjct: 484 QRVEEQL---------RLRERELT----ALKGALKEEVASRDQEVEHVRQQYQRDTEQLR 530
Query: 211 EQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCL---NRQDVPKTTPSL 267
Q T + LE +Q++ L+ ++ G H Q + N++D+ T L
Sbjct: 531 RSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETG-HWQSMFQKNKEDLRATKQEL 589
Query: 268 PQ 269
Q
Sbjct: 590 LQ 591
Score = 37.4 bits (85), Expect = 0.015
Identities = 58/273 (21%), Positives = 117/273 (42%), Gaps = 59/273 (21%)
Query: 9 KQAQTQRKQLL---EESRELHREKLLVQAENRF----------FLEYLTNKTEEYTEQPE 55
+Q + +K+LL EE +EL E+ + R L ++ E EQ
Sbjct: 625 RQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQ-- 682
Query: 56 KVWNSYLQKSGEIERRRQESASR-----------YAEQISVLKTALLQKENIQSSLKRKL 104
N LQK+ + R+ E AS+ ++ + ++T L + + +R++
Sbjct: 683 ---NLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRI 739
Query: 105 ----QAMRDIAILKEKQEKEIQTLQEETKKVQAE------TASKTREVQAQLLQEKRLLE 154
Q +++ L + E L+++ ++++AE + ++E + L KR LE
Sbjct: 740 LGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALE 799
Query: 155 KQLSEPDRRL--LGKR------------KRRELNMKAQALKLAAKRFIFEYSCGINRENQ 200
+L E R L LG+ K+RE+ + +A KR + +N+E +
Sbjct: 800 ARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE 859
Query: 201 QFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 233
+ ++ Q ++Q Q+ LE+ K++ ++E
Sbjct: 860 KIGEDSKQALQQ------LQAQLEDYKEKARRE 886
Score = 35.0 bits (79), Expect = 0.072
Identities = 58/257 (22%), Positives = 103/257 (40%), Gaps = 39/257 (15%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
K+ QR Q LE+ E K Q + L+ L K + ++ N+ + +
Sbjct: 936 KELLAQRLQGLEQEAE---NKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRV 992
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLK-RKLQAMRDIAILKEKQ---------- 117
R R +Q+ L+T L+Q+ + + L+ K+ R LK +
Sbjct: 993 NRGR--------DQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPS 1044
Query: 118 ------EKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRR 171
E + Q LQE ++QAE KT E+++ E + D R ++
Sbjct: 1045 ASLSQLESQNQLLQE---RLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKD 1101
Query: 172 ELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 231
+L+++ +AL KR + E I R + KK ++ EQ + L+ R + L+
Sbjct: 1102 QLSLRVKAL----KRQVDEAEEEIERLDGLRKKAQREVEEQHE----VNEQLQARIKSLE 1153
Query: 232 QEQWYLESLIQARQRLQ 248
++ W S A L+
Sbjct: 1154 KDSWRKASRSAAESALK 1170
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 57.4 bits (137), Expect = 1e-08
Identities = 57/238 (23%), Positives = 110/238 (46%), Gaps = 28/238 (11%)
Query: 12 QTQRKQLLEESREL-HREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIER 70
+T + QL E+++EL H + L A+ L K +++++ ++ W + + + +
Sbjct: 1165 ETLQGQLEEKAQELGHSQSALASAQRE--LAAFRTKVQDHSKAEDE-WKAQVARGRQEAE 1221
Query: 71 RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKK 130
R+ S E++S+L +L+KE LKR + A + +K E+ ++ LQ ET
Sbjct: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE---KSQKLEERLRLLQAETAS 1278
Query: 131 VQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKA-------QALKLA 183
A A ++ ++ ++ + EKQ R+ + R+EL +A Q LK
Sbjct: 1279 NSARAAERSSALREEVQSLREEAEKQ------RVASENLRQELTSQAERAEELGQELKAW 1332
Query: 184 AKRFIFEYSCGI------NRENQQFKKELLQLIEQAQKLTATQSHLENR-KQQLQQEQ 234
++F F+ + + Q ELL Q+L A Q+ E R +++L+Q +
Sbjct: 1333 QEKF-FQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSK 1389
Score = 48.5 bits (114), Expect = 6e-06
Identities = 55/246 (22%), Positives = 104/246 (42%), Gaps = 28/246 (11%)
Query: 1 MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS 60
+TDL I +Q K+ LE++ + H +L Q + + T E T +
Sbjct: 468 ITDLQSSISNL-SQAKEELEQASQAHGARLTAQ---------VASLTSELTTLNATIQ-- 515
Query: 61 YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE 120
Q+ E+ +Q++ + A+ L L Q+E L+ +++ + KE+Q KE
Sbjct: 516 --QQDQELAGLKQQAKEKQAQ----LAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
Query: 121 IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL 180
+ QE T++ A+ + E + L+E+ KQL L K K +L + Q L
Sbjct: 570 VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQL-----EALEKEKAAKLEILQQQL 624
Query: 181 KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 240
++A E Q ++E +L + ++L A + + Q + LE
Sbjct: 625 QVAN-----EARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ 679
Query: 241 IQARQR 246
+++ Q+
Sbjct: 680 LRSEQQ 685
Score = 46.6 bits (109), Expect = 2e-05
Identities = 70/269 (26%), Positives = 120/269 (44%), Gaps = 30/269 (11%)
Query: 4 LNKHIKQAQ---TQRKQLLEESRELHREKLLVQAENRFF---LEYLTNKTEEYTEQPEKV 57
L++ +KQ Q T++ Q+ + +L E + + R F L+ L + E TE+ K
Sbjct: 292 LHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKA 351
Query: 58 WNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQ 117
+L+K ++E ++ SA+ ++ K +LQ + S L+ L ++D +EK
Sbjct: 352 TQEWLEKQAQLE--KELSAALQDKKCLEEKNEILQGK--LSQLEEHLSQLQDNP-PQEKG 406
Query: 118 EKEIQTLQEETKKVQAET-ASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK 176
E LQ ET K +A T A+ ++QA++ +LE + + + +LL +R E
Sbjct: 407 EVLGDVLQLETLKQEAATLAANNTQLQARV----EMLETERGQQEAKLLAERGHFEEE-- 460
Query: 177 AQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQ--KLTA----TQSHLENRKQQL 230
K I + I+ +Q KE L+ QA +LTA S L +
Sbjct: 461 ----KQQLSSLITDLQSSISNLSQ--AKEELEQASQAHGARLTAQVASLTSELTTLNATI 514
Query: 231 QQEQWYLESLIQARQRLQGSHNQCLNRQD 259
QQ+ L L Q + Q Q L +Q+
Sbjct: 515 QQQDQELAGLKQQAKEKQAQLAQTLQQQE 543
Score = 44.3 bits (103), Expect = 1e-04
Identities = 49/182 (26%), Positives = 79/182 (43%), Gaps = 31/182 (17%)
Query: 17 QLLEESRELH--REKLLVQAEN-RFFLEYLTNKTEEYT------EQPEKVWNSYLQKSGE 67
++LEE + R+KL Q E F T + EE + +Q KV L+
Sbjct: 1518 KVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQA 1577
Query: 68 IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ----- 122
Q+ A R Q++ L+ L QKE K +++ + K++Q +E+Q
Sbjct: 1578 QGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRS 1637
Query: 123 --TLQEETKKVQAETASKTREVQAQLLQEK-------------RLLEKQLSEPDRRL--L 165
LQ+E K+++AE E+Q L+ K R LE Q++ D++L L
Sbjct: 1638 LEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
Query: 166 GK 167
GK
Sbjct: 1698 GK 1699
Score = 38.5 bits (88), Expect = 0.007
Identities = 64/279 (22%), Positives = 113/279 (40%), Gaps = 39/279 (13%)
Query: 1 MTDLNKHIKQAQTQRKQL---LEESRELHREK--LLVQAENRFFLEYLTNKTEEYTEQPE 55
M L K + ++ R +L L E+R+L EK + + R L N+ + +
Sbjct: 216 MRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEP 275
Query: 56 KVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKE 115
K K+ + R E+ +Q LKT +K + + + + D++
Sbjct: 276 KELEELRDKNESLTMRLHETL----KQCQDLKT---EKSQMDRKINQLSEENGDLSFKLR 328
Query: 116 KQEKEIQTLQEETKKVQAETASKTR---EVQAQL-------LQEKRLLEK---------- 155
+ +Q LQ+ ++ E + T+ E QAQL LQ+K+ LE+
Sbjct: 329 EFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLS 388
Query: 156 QLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLI--EQA 213
QL E +L + + + L+L + + N Q + E+L+ +Q
Sbjct: 389 QLEEHLSQLQDNPPQEKGEVLGDVLQLETLK-QEAATLAANNTQLQARVEMLETERGQQE 447
Query: 214 QKLTATQSHLENRKQQLQ----QEQWYLESLIQARQRLQ 248
KL A + H E KQQL Q + +L QA++ L+
Sbjct: 448 AKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELE 486
Score = 37.7 bits (86), Expect = 0.011
Identities = 49/261 (18%), Positives = 108/261 (41%), Gaps = 19/261 (7%)
Query: 6 KHIKQAQTQRKQL---LEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYL 62
K +++ + RK L L++ E H+ + V + E EQ K ++
Sbjct: 755 KELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWR 814
Query: 63 QKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ 122
++ + ++ + + + EQ+ LK E + + + +A +A ++ E +I
Sbjct: 815 ERYEDSQQEEAQYGAMFQEQLMTLK------EECEKARQELQEAKEKVAGIESHSELQIS 868
Query: 123 TLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKR----RELNMKAQ 178
Q E ++ A A ++VQ + ++ ++L + LS ++ K L KA
Sbjct: 869 RQQNELAELHANLARALQQVQEKEVRAQKLAD-DLSTLQEKMAATSKEVARLETLVRKAG 927
Query: 179 ALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLE 238
+ A R + + ++ +E +Q ++ +TQ+ L+ +++ +Q LE
Sbjct: 928 EQQETASRELVKEPARAGDRQPEWLEE-----QQGRQFCSTQAALQAMEREAEQMGNELE 982
Query: 239 SLIQARQRLQGSHNQCLNRQD 259
L A QG + +Q+
Sbjct: 983 RLRAALMESQGQQQEERGQQE 1003
Score = 37.7 bits (86), Expect = 0.011
Identities = 48/275 (17%), Positives = 120/275 (43%), Gaps = 11/275 (4%)
Query: 1 MTDLNKHIKQAQTQRKQLLEESRELHREKLL-----VQAENRFFLEYLTNKTEEYTEQPE 55
+ + N+ + + +Q LE + REK + V+A+ L + + + + E
Sbjct: 1447 LAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELE 1506
Query: 56 KVWNSYLQKSGEI--ERRR-QESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAI 112
+ Y ++ ER+R QE + Q+ L+ ++ L +KL +
Sbjct: 1507 VMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASK 1566
Query: 113 LKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRE 172
+++++ K +Q E+++ ++ E+QAQL Q+++ E + ++ +++
Sbjct: 1567 VQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQ 1626
Query: 173 LNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 232
N + Q +L + + + + + E ++ EL Q + ++ T HL + + L+
Sbjct: 1627 QNQELQE-QLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEA 1685
Query: 233 EQWYLESLIQARQRLQGSHNQCLNRQDVPKTTPSL 267
+ + + ++ + Q + + +R+ P+ P L
Sbjct: 1686 QVAHADQQLRDLGKFQVATDALKSRE--PQAKPQL 1718
Score = 35.8 bits (81), Expect = 0.042
Identities = 54/253 (21%), Positives = 112/253 (44%), Gaps = 38/253 (15%)
Query: 4 LNKHIKQAQTQRKQLLEE---SRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS 60
L+ +KQ + Q K++ E+ +R+ H ++L AE R E + ++
Sbjct: 556 LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEER--------------EASLRERDA 601
Query: 61 YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE 120
L++ +E+ + +Q+ V A +++ Q+S+ QA R+ A L K E E
Sbjct: 602 ALKQLEALEKEKAAKLEILQQQLQVANEA---RDSAQTSVT---QAQREKAELSRKVE-E 654
Query: 121 IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL 180
+Q E ++ Q E QAQ+ + + L + + + +++ +L + QAL
Sbjct: 655 LQACVETARQEQ-------HEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQAL 707
Query: 181 KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 240
K + K + G E ++ + L+ EQ + ++ ++ + +Q ++E+ LE
Sbjct: 708 KESLK-----VTKGSLEEEKRRAADALE--EQQRCISELKAETRSLVEQHKRERKELEEE 760
Query: 241 IQARQRLQGSHNQ 253
R+ L+ Q
Sbjct: 761 RAGRKGLEARLQQ 773
Score = 34.7 bits (78), Expect = 0.094
Identities = 52/243 (21%), Positives = 102/243 (41%), Gaps = 29/243 (11%)
Query: 11 AQTQRKQLLEES---RELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQKSG 66
A+++ +QL++E RE + + +A+ F E L EE E+ + +K
Sbjct: 799 AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEE-CEKARQELQEAKEKVA 857
Query: 67 EIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQE 126
IE + SR +++ L ++L R LQ +++ + +K ++ TLQE
Sbjct: 858 GIESHSELQISRQQNELAEL----------HANLARALQQVQEKEVRAQKLADDLSTLQE 907
Query: 127 ETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKR 186
+ E A V+ Q++ + + EP R G R+ L + ++
Sbjct: 908 KMAATSKEVARLETLVRKAGEQQETASRELVKEPAR--AGDRQPEWLE------EQQGRQ 959
Query: 187 FIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ-QEQWYLESLIQARQ 245
F C Q ++E Q+ + ++L A + ++Q+ + Q++ + L Q R
Sbjct: 960 F-----CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERG 1014
Query: 246 RLQ 248
R Q
Sbjct: 1015 RAQ 1017
Score = 32.3 bits (72), Expect = 0.47
Identities = 51/267 (19%), Positives = 114/267 (42%), Gaps = 29/267 (10%)
Query: 3 DLNKHIKQAQTQ--RKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS 60
+L + ++Q Q + R Q L + +EK+ ++ LE L K E E +
Sbjct: 880 NLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVK 939
Query: 61 YLQKSGEIERR--RQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEK-- 116
++G+ + ++ ++ + L+ + E + + L+R A+ + +++
Sbjct: 940 EPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEER 999
Query: 117 --QEKEIQTLQEETKKVQAETA---SKTREVQAQL---LQEKRLLEKQLSEPDRRLLGKR 168
QE+E+ L +E + QA+ A + E++ +L L E+R+ L E L ++
Sbjct: 1000 GQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEK 1059
Query: 169 KRRELNM-KAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIE--------------QA 213
+ ++ + K + L+ A + + E + + +Q K+ +
Sbjct: 1060 EGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTG 1119
Query: 214 QKLTATQSHLENRKQQLQQEQWYLESL 240
KL A ++ + +QQ Q++Q +SL
Sbjct: 1120 PKLEALRAEVSKLEQQCQKQQEQADSL 1146
Score = 28.9 bits (63), Expect = 5.2
Identities = 52/231 (22%), Positives = 96/231 (41%), Gaps = 26/231 (11%)
Query: 9 KQAQTQRKQLLEESR----ELHREKLLVQAENRFFLEY-LTNKTEEYTEQPEKVWNSYLQ 63
+ A ++ + LE+ + E+ +++L V E R + +T E E KV LQ
Sbjct: 599 RDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKV--EELQ 656
Query: 64 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL-KRKLQAMRDIAILKEKQEKEIQ 122
E R+ Q A ++ + + QK + + + K Q + LKE +
Sbjct: 657 ACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKG 716
Query: 123 TLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKL 182
+L+EE K+ A+ + + ++L E R L +Q KR+R+EL + K
Sbjct: 717 SLEEE-KRRAADALEEQQRCISELKAETRSLVEQ---------HKRERKELEEERAGRKG 766
Query: 183 AAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 233
R + + E + ++EL + + A Q E+ +QL +E
Sbjct: 767 LEAR-LQQLGEAHQAETEVLRRELAEAM-------AAQHTAESECEQLVKE 809
>gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo
sapiens]
Length = 551
Score = 57.0 bits (136), Expect = 2e-08
Identities = 53/232 (22%), Positives = 106/232 (45%), Gaps = 15/232 (6%)
Query: 15 RKQLLEESRELHREKLLV----QAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIER 70
R+Q++E+ + E+ L+ + E LEY+ EE + E+ L+ EI+R
Sbjct: 258 RRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKR 317
Query: 71 RRQESASRYAEQISVLKTA-LLQKENIQSSLKRKLQAMRDIAILKEKQEKEI---QTLQE 126
E+ + AE ++ K A + E + + R+ + + ++ ++EKEI + +QE
Sbjct: 318 INDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQE 377
Query: 127 ETKKVQAET----ASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKL 182
+ + QAE A + +EV + + K + L K + ++ K AL +
Sbjct: 378 KAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAV 437
Query: 183 AAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQ 234
+R E+ + + +Q +KE L E+ +K T H ++Q+++ Q
Sbjct: 438 QVQRDRDEFERILRAQREQIEKERL---EEEKKATGRLQHANELRRQVRENQ 486
Score = 48.1 bits (113), Expect = 8e-06
Identities = 46/197 (23%), Positives = 92/197 (46%), Gaps = 31/197 (15%)
Query: 62 LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL------KRKLQAMRDIAILKE 115
+Q+ E+ER+R+E R QI ++K + SL + K Q + + L+E
Sbjct: 240 IQRQEELERKRREERIRGRRQI----VEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQE 295
Query: 116 KQEKEIQTLQEETKKVQAETA---SKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRE 172
+ K+++ Q++ K+QAE + ++ +A+LL +++L ++ + E K+ RE
Sbjct: 296 EDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVME----FTKKKMARE 351
Query: 173 LNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLE-NRKQQLQ 231
+A+ + I RE ++ L + E+AQ A Q L R Q++
Sbjct: 352 AEFEAEQER-------------IRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVA 398
Query: 232 QEQWYLESLIQARQRLQ 248
+W + AR++++
Sbjct: 399 DREWRRKEKENARKKME 415
Score = 28.9 bits (63), Expect = 5.2
Identities = 29/148 (19%), Positives = 62/148 (41%), Gaps = 13/148 (8%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
K+ + RK++ E EL + +L A L + + E+ + ++K
Sbjct: 405 KEKENARKKM-ETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLE 463
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
E ++ ++A ++ +EN Q ++ ++ + LKE+ +K + + E
Sbjct: 464 EEKKATGRLQHANELR-----RQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIK 518
Query: 129 KKVQAETASKTREVQAQLLQEKRLLEKQ 156
+K K E++A L EK +E +
Sbjct: 519 RK-------KLEELRATGLPEKYCIEAE 539
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 56.6 bits (135), Expect = 2e-08
Identities = 62/250 (24%), Positives = 116/250 (46%), Gaps = 37/250 (14%)
Query: 17 QLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESA 76
++ EE+R RE L Q E + E +QP+ Q E++++ Q+
Sbjct: 77 EIAEETRPGQRELQLQQLEQQ----------PEPQQQPQHEQLQQPQPHLELQQQPQQDG 126
Query: 77 SRYAEQISVLKTALLQKENIQS----SLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQ 132
+ Q LQ+E QS LK +LQ M L+ +Q +E Q LQ++ +++Q
Sbjct: 127 QQQLSQ--------LQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQ 178
Query: 133 AETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYS 192
+ A + Q+LQ++ L++Q+ E + + ++ + Q +L ++F +
Sbjct: 179 TQQAQ-----EQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQ-- 231
Query: 193 CGINRENQQFKKELLQLIEQA----QKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQ 248
+E Q +++LL L +Q Q L Q+ L+ + + QQ Q + L+Q +++LQ
Sbjct: 232 ----QEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQ 287
Query: 249 GSHNQCLNRQ 258
Q L +Q
Sbjct: 288 QQQQQQLLQQ 297
Score = 53.5 bits (127), Expect = 2e-07
Identities = 55/258 (21%), Positives = 125/258 (48%), Gaps = 35/258 (13%)
Query: 9 KQAQTQRKQLLEESRELHREKLL----VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQK 64
K ++L E + +H+++ L VQ + R + +T++ EQ LQ+
Sbjct: 137 KHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQ 196
Query: 65 SGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTL 124
+ ++ Q+ + +Q + + LQ++ Q + +LQ + + +L+++ + + Q L
Sbjct: 197 QVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQ-QEQLQQQQQLLLLQQQGQLQQQLL 255
Query: 125 QEETKKVQAETASKTR-EVQAQLL------------------QEKRLLEKQLSEPDRRLL 165
Q++ ++Q + + + ++Q QLL Q+++L ++QL P L
Sbjct: 256 QQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPP---L 312
Query: 166 GKRKRRELNMKAQALKLAAKRFIFEYSCGINR----ENQQFKKEL-LQLIEQAQKLTATQ 220
+ E+ ++ + L +++ + + + R E QQ +++L L+L E+ Q+L +
Sbjct: 313 EPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQQL---E 369
Query: 221 SHLENRKQQLQQEQWYLE 238
LE ++QQL+Q++ LE
Sbjct: 370 QQLEQQQQQLEQQEVQLE 387
Score = 36.6 bits (83), Expect = 0.025
Identities = 37/156 (23%), Positives = 78/156 (50%), Gaps = 17/156 (10%)
Query: 9 KQAQTQRKQLLEESRELHREK---LLVQAENRFFLEYLTNKTEEYTEQPE---KVWNSYL 62
+QAQ Q++ LL++ +L +++ LL Q + + + L E E+ E ++ L
Sbjct: 270 QQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDL 329
Query: 63 QKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQA-MRDIAILKEKQEKEI 121
E+E++RQE R E L+++ Q L+ KLQ ++ + E+Q++++
Sbjct: 330 GSEQELEQQRQE-LERQQE---------LERQQEQRQLQLKLQEELQQLEQQLEQQQQQL 379
Query: 122 QTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQL 157
+ + + + E ++ +EVQ +L + L+ +L
Sbjct: 380 EQQEVQLELTPVELGAQQQEVQLELTPVQPELQLEL 415
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 56.2 bits (134), Expect = 3e-08
Identities = 68/259 (26%), Positives = 117/259 (45%), Gaps = 31/259 (11%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVW--NSYLQKSG 66
+Q + Q K ++ +R+ EK + E + EE E PE+ +S + G
Sbjct: 296 RQVRIQLKDHIDRTRKKRGEKDETEYE-------YSGSEEEEEEVPEQEGEPSSIVNVPG 348
Query: 67 EIERRR------QESASRYAEQISVLKTALLQKENI--QSSLKRKLQAMRDIAILKEKQE 118
E RR QE+ R ++ + LLQ++ + Q KR+L A R I E+Q+
Sbjct: 349 ESTLRRDFLRLQQENKERSE---ALRRQQLLQEQQLREQEEYKRQLLAERQKRI--EQQK 403
Query: 119 KEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLE----KQLSEPDRRLLGKRKRRELN 174
++ + L+E+ ++ + + RE + + +EKR LE ++ E +RR + KRR
Sbjct: 404 EQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRR--- 460
Query: 175 MKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQ 234
+ + +R + E + QQ +E L+E + E ++QLQQEQ
Sbjct: 461 --VEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQ 518
Query: 235 WYLESLIQARQRLQGSHNQ 253
YL SL +R H+Q
Sbjct: 519 AYLLSLQHDHRRPHPQHSQ 537
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 55.5 bits (132), Expect = 5e-08
Identities = 58/237 (24%), Positives = 102/237 (43%), Gaps = 24/237 (10%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+Q + Q K ++ +++ EK + E + EE E +S L GE
Sbjct: 296 RQVRIQLKDHIDRTKKKRGEKDETEYE-------YSGSEEEEEENDSGEPSSILNLPGES 348
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
RR L+ L KE ++ +++L+ + +E +E + Q L E
Sbjct: 349 TLRRD-----------FLRLQLANKERSEALRRQQLEQQQ-----RENEEHKRQLLAERQ 392
Query: 129 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 188
K+++ E + R ++ Q +EK L ++Q E R + +R E +A+ + +R +
Sbjct: 393 KRIE-EQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451
Query: 189 FEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQ 245
E + QQ E L+E +K Q E ++QL+QE+ YL SL RQ
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ 508
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 55.5 bits (132), Expect = 5e-08
Identities = 58/237 (24%), Positives = 102/237 (43%), Gaps = 24/237 (10%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+Q + Q K ++ +++ EK + E + EE E +S L GE
Sbjct: 296 RQVRIQLKDHIDRTKKKRGEKDETEYE-------YSGSEEEEEENDSGEPSSILNLPGES 348
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
RR L+ L KE ++ +++L+ + +E +E + Q L E
Sbjct: 349 TLRRD-----------FLRLQLANKERSEALRRQQLEQQQ-----RENEEHKRQLLAERQ 392
Query: 129 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 188
K+++ E + R ++ Q +EK L ++Q E R + +R E +A+ + +R +
Sbjct: 393 KRIE-EQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451
Query: 189 FEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQ 245
E + QQ E L+E +K Q E ++QL+QE+ YL SL RQ
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ 508
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 55.5 bits (132), Expect = 5e-08
Identities = 58/237 (24%), Positives = 102/237 (43%), Gaps = 24/237 (10%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+Q + Q K ++ +++ EK + E + EE E +S L GE
Sbjct: 296 RQVRIQLKDHIDRTKKKRGEKDETEYE-------YSGSEEEEEENDSGEPSSILNLPGES 348
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
RR L+ L KE ++ +++L+ + +E +E + Q L E
Sbjct: 349 TLRRD-----------FLRLQLANKERSEALRRQQLEQQQ-----RENEEHKRQLLAERQ 392
Query: 129 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 188
K+++ E + R ++ Q +EK L ++Q E R + +R E +A+ + +R +
Sbjct: 393 KRIE-EQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451
Query: 189 FEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQ 245
E + QQ E L+E +K Q E ++QL+QE+ YL SL RQ
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ 508
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 55.5 bits (132), Expect = 5e-08
Identities = 58/237 (24%), Positives = 102/237 (43%), Gaps = 24/237 (10%)
Query: 9 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 68
+Q + Q K ++ +++ EK + E + EE E +S L GE
Sbjct: 296 RQVRIQLKDHIDRTKKKRGEKDETEYE-------YSGSEEEEEENDSGEPSSILNLPGES 348
Query: 69 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 128
RR L+ L KE ++ +++L+ + +E +E + Q L E
Sbjct: 349 TLRRD-----------FLRLQLANKERSEALRRQQLEQQQ-----RENEEHKRQLLAERQ 392
Query: 129 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 188
K+++ E + R ++ Q +EK L ++Q E R + +R E +A+ + +R +
Sbjct: 393 KRIE-EQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451
Query: 189 FEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQ 245
E + QQ E L+E +K Q E ++QL+QE+ YL SL RQ
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ 508
>gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens]
Length = 775
Score = 55.5 bits (132), Expect = 5e-08
Identities = 49/186 (26%), Positives = 89/186 (47%), Gaps = 7/186 (3%)
Query: 66 GEIERRRQESASRYAEQISVLKTALLQKENIQSS-LKRKLQAMRDIAILKEKQEKEIQTL 124
GE+++R + ++ A S L T +K +++S L K + +D+ K E+E L
Sbjct: 152 GEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARL 211
Query: 125 QEETKKVQ---AETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRR---ELNMKAQ 178
+ E K +Q AET ++ Q QE+ L E + L +R +R EL ++
Sbjct: 212 EGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEET 271
Query: 179 ALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLE 238
LA + + E G + +Q +E+ +L + Q + ++ + R Q+LQ+E L+
Sbjct: 272 REALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLK 331
Query: 239 SLIQAR 244
S QA+
Sbjct: 332 SHFQAQ 337
Score = 33.5 bits (75), Expect = 0.21
Identities = 32/97 (32%), Positives = 46/97 (47%), Gaps = 15/97 (15%)
Query: 68 IERRRQESASRY--AEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQ 125
+E R+ A R AEQ+ + Q LK +LQA+RD K + + +Q LQ
Sbjct: 268 LEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRD---EKNQPDPRLQELQ 324
Query: 126 EETKKVQAETASKTREVQAQLLQEKR---LLEKQLSE 159
EE ++++ QAQL QE R L E QL +
Sbjct: 325 EEAARLKS-------HFQAQLQQEMRKTALAEDQLRQ 354
>gi|134152708 arginine and glutamate rich 1 [Homo sapiens]
Length = 273
Score = 55.5 bits (132), Expect = 5e-08
Identities = 53/254 (20%), Positives = 119/254 (46%), Gaps = 38/254 (14%)
Query: 5 NKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQK 64
+KH K ++ +K+ SR +E++ ++++R E N+ E + + ++
Sbjct: 12 SKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSR---ESKRNRRRESRSRSRSTNTAVSRR 68
Query: 65 SGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTL 124
R +E AS ++I + + ++ ++ KR+ + + + +++++I+
Sbjct: 69 E-----RDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKK----AEFERQRKIRQQ 119
Query: 125 QEETKKVQAETASKTREVQAQLLQE--------------------KRLLEKQLSEPDRRL 164
+ E K ++ ETA + E+ A+ ++E KR++EKQL E R
Sbjct: 120 EIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQ 179
Query: 165 ----LGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQ 220
L +K RE +A+ +L +R + E + I + +E L+++E+ +K+ +
Sbjct: 180 RQAELAAQKAREEEERAKREEL--ERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEER 237
Query: 221 SHLENRKQQLQQEQ 234
LE +Q+ Q+E+
Sbjct: 238 MKLEQERQRQQKEE 251
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 55.1 bits (131), Expect = 7e-08
Identities = 59/269 (21%), Positives = 123/269 (45%), Gaps = 27/269 (10%)
Query: 1 MTDLNKHIKQAQTQRKQLLEES-------------RELHREKLLV-----QAENRFF--- 39
+TD K A+ Q K L ES R+L R KLL+ QAE
Sbjct: 275 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 334
Query: 40 LEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 99
L+ ++ K + E+ E +WN Q+ E R++E + E+I + + ++E
Sbjct: 335 LQSVSAKLQAQVEENE-LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIRE 393
Query: 100 LKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSE 159
+ K++ ++ + EK+EK QEE + E + E+ + ++ R LE+++ E
Sbjct: 394 QEEKMRRQEEM--MWEKEEK--MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE 449
Query: 160 PDR-RLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 218
++ R ++++ E ++ Q + + ++ I + ++ +++ ++ Q +K+
Sbjct: 450 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE 509
Query: 219 TQSHLENRKQQLQQEQWYLESLIQARQRL 247
+ E K+Q Q+E W E I+ ++ +
Sbjct: 510 QEKIREEEKRQEQEEMWRQEEKIREQEEI 538
Score = 48.1 bits (113), Expect = 8e-06
Identities = 47/214 (21%), Positives = 105/214 (49%), Gaps = 29/214 (13%)
Query: 14 QRKQLLEESRELHR--EKLLVQAENRFFLEY-LTNKTEEYTEQPEKVWNSYLQKSGEIER 70
+++++ + ++H EK+ Q E + E + ++ E+ EQ EKVW +K E E
Sbjct: 534 EQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQE-EKIREQEE 592
Query: 71 RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKK 130
+ +E + EQ + + Q+E + ++ + + +EK ++ + ++E+ KK
Sbjct: 593 KIREQEEKIREQEEMTQE---QEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKK 649
Query: 131 VQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFE 190
++ E K RE Q +++QE+ E+++ E + ++ +E M+ Q K+
Sbjct: 650 IR-EQEEKIRE-QEEMMQEQ---EEKMWEQEEKMC----EQEEKMQEQEEKM-------- 692
Query: 191 YSCGINRENQQFKKELLQLIEQAQKLTATQSHLE 224
R+ ++ ++ ++L +Q +K+ Q HLE
Sbjct: 693 -----RRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 42.4 bits (98), Expect = 5e-04
Identities = 46/233 (19%), Positives = 112/233 (48%), Gaps = 9/233 (3%)
Query: 9 KQAQTQRKQLLEESRELHR-EKLLVQAENRFF-LEYLTNKTEEYTEQPEKVWNSYLQKSG 66
++ + Q + + E+ ++ R E+++ + E + LE ++ E+ EQ EK +K
Sbjct: 410 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE--EKIR 467
Query: 67 EIERRRQESAS--RYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTL 124
E E+R+++ A R E+I + + ++E + K+ I +++QE+E
Sbjct: 468 EQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWR 527
Query: 125 QEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKA--QALKL 182
QEE + Q E + ++ Q + ++ EK + ++ + K RE K Q K+
Sbjct: 528 QEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKI 587
Query: 183 -AAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQ 234
+ I E I + + +++ ++ EQ +K+ + ++ +++++++++
Sbjct: 588 REQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQE 640
Score = 35.4 bits (80), Expect = 0.055
Identities = 37/145 (25%), Positives = 64/145 (44%), Gaps = 20/145 (13%)
Query: 105 QAMRDIAILKEKQEKEIQTLQEETKKVQAE------TASKTREVQAQLLQEKRLLEKQLS 158
QA+ +A K+K ++ I+ L +E + E T + +E A+L ++ +L+E + S
Sbjct: 240 QALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKS 299
Query: 159 EPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 218
E +LN+K KL + + + E KE LQ + +
Sbjct: 300 E-----------IQLNVKELKRKLERAKLLLPQQ-QLQAEADHLGKE-LQSVSAKLQAQV 346
Query: 219 TQSHLENRKQQLQQEQ-WYLESLIQ 242
++ L NR Q Q+E+ W E IQ
Sbjct: 347 EENELWNRLNQQQEEKMWRQEEKIQ 371
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 55.1 bits (131), Expect = 7e-08
Identities = 59/232 (25%), Positives = 105/232 (45%), Gaps = 24/232 (10%)
Query: 4 LNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 63
LN + Q K L + REL K V +E + L+NK E+ ++ ++ Q
Sbjct: 273 LNIQVDFLQQANKDLEKRIRELMETKETVTSE----VVNLSNKNEKLCQELTEID----Q 324
Query: 64 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 123
+ ++ER ++E VL+TA + + +KRKL M+D+ K + E+
Sbjct: 325 LAQQLERHKEE----------VLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNL 374
Query: 124 LQEETKKVQAETASKT--REVQAQLLQEKRLLEKQLSE---PDRRLLGKRKRRELNMKAQ 178
Q+E +++ E K+ V QL QEK+ L K++ +R+L + +R L +
Sbjct: 375 CQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIK 434
Query: 179 ALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQL 230
+ R + + GI E +KKEL +L Q+ + + S+ K +
Sbjct: 435 RRDRSPSR-LDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSI 485
Score = 29.3 bits (64), Expect = 4.0
Identities = 35/183 (19%), Positives = 83/183 (45%), Gaps = 21/183 (11%)
Query: 67 EIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQE 126
E R +E+ Y E + + + + + +++SLK+ + D+ L + +++ L++
Sbjct: 74 ENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEK 133
Query: 127 ETKKVQAETASKTREVQAQLLQEKRL--LEKQLSEPDRRLLGKRKRRELNMKAQALKLAA 184
E SK + + Q LQEK L + + R + +R+R +++ ++++
Sbjct: 134 E---------SKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSS 184
Query: 185 -------KRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYL 237
+I + + Q+ ++E+ QL E KL +S + + +Q++ + +
Sbjct: 185 YPVPQPDDPYIADLLQVADNRIQELQQEVHQLQE---KLAMMESGVRDYSKQIELREREI 241
Query: 238 ESL 240
E L
Sbjct: 242 ERL 244
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 55.1 bits (131), Expect = 7e-08
Identities = 45/189 (23%), Positives = 95/189 (50%), Gaps = 12/189 (6%)
Query: 43 LTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKR 102
L TEE +E EK+ KSG++E +QE+A+ +Q+ +K LQ++ + + +R
Sbjct: 799 LEEGTEETSETLEKLREELAIKSGQVEHLQQETAA-LKKQMQKIKEQFLQQKVMVEAYRR 857
Query: 103 ----KLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLS 158
K Q + ++ +++ + E++ L++E +V E + E+ ++L +E + + ++
Sbjct: 858 DATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAEL-SRLHREVAQVRQHMA 916
Query: 159 EPDRRLLGKRKRR-ELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLT 217
+ + L +K R E+ Q+L +F E + N+ KK++ +L ++A+K
Sbjct: 917 DLEGHLQSAQKERDEMETHLQSL-----QFDKEQMVAVTEANEALKKQIEELQQEARKAI 971
Query: 218 ATQSHLENR 226
Q R
Sbjct: 972 TEQKQKMRR 980
Score = 50.4 bits (119), Expect = 2e-06
Identities = 63/260 (24%), Positives = 114/260 (43%), Gaps = 32/260 (12%)
Query: 2 TDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSY 61
T L K +++ Q LEESRE E E+R F + K + E +K+
Sbjct: 1059 TLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRK----KIKRLEESNKKLALEL 1114
Query: 62 LQKSGEIERRRQESASRYAEQISVLKTALLQKE--------NIQSSLKRKLQAMRDIAIL 113
+ G++ Q +A+ E S+L+TAL ++E +Q+ L+RK + R + L
Sbjct: 1115 EHEKGKLTGLGQSNAA-LREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHL 1173
Query: 114 -------KEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLG 166
EK+++++ +L+E+ + E R +A L +LSE + L
Sbjct: 1174 VQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASL--------ELSEVKKELQA 1225
Query: 167 KRKR-RELNMKAQALKLAAKRF---IFEYSCGINRENQQFKKELLQLIEQAQKLTATQSH 222
K ++L +A L++ + I ++ + Q + QL EQ K
Sbjct: 1226 KEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQE 1285
Query: 223 LENRKQQLQQEQWYLESLIQ 242
+EN K ++ Q++ ++SL Q
Sbjct: 1286 MENLKWEVDQKEREIQSLKQ 1305
Score = 38.5 bits (88), Expect = 0.007
Identities = 56/260 (21%), Positives = 99/260 (38%), Gaps = 33/260 (12%)
Query: 2 TDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSY 61
T ++ I + + RK+L E +EL +E + V E R L+ E +
Sbjct: 860 TSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQ--------V 911
Query: 62 LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEI 121
Q ++E Q + E + L++ KE + + + E +K+I
Sbjct: 912 RQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVA-----------VTEANEALKKQI 960
Query: 122 QTLQEETKKVQAETASKTREVQAQL--LQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQA 179
+ LQ+E +K E K R + + L Q++ + + E +L +R + L K A
Sbjct: 961 EELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAA 1020
Query: 180 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLES 239
+ G R L L E+ Q L A + + K L++E E
Sbjct: 1021 ----------DAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKE--LQEV 1068
Query: 240 LIQARQRLQGSHNQCLNRQD 259
+ Q L+ S + L +D
Sbjct: 1069 IALTSQELEESREKVLELED 1088
Score = 37.0 bits (84), Expect = 0.019
Identities = 56/301 (18%), Positives = 121/301 (40%), Gaps = 56/301 (18%)
Query: 8 IKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 67
+KQ+ ++ + + + + K A + L+ + + + E + S L K
Sbjct: 473 LKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNT 532
Query: 68 IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE 127
+ RQ+ + ++ L+ L++ + S LK + + +++ ++++ QE
Sbjct: 533 VHDLRQQMTALQSQ----LQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEA 588
Query: 128 TKKVQAETA--SKTREVQAQLLQEKRL----LEKQLSEPDRRLLGKRKRRE--------- 172
++Q E A + QA LL+ +L L +QL+E R + ++ R
Sbjct: 589 RVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEAD 648
Query: 173 -LNMKAQALKLAAKRFIFEY----------------------SCGINRENQQFKKELLQL 209
L+ +A +++ + + E + + ++ +Q K LLQ
Sbjct: 649 MLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQR 708
Query: 210 IEQAQ-----------KLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 258
+Q + +LT TQ L++R+Q L Q + + L LQG + +R+
Sbjct: 709 DQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQG---EAASRE 765
Query: 259 D 259
D
Sbjct: 766 D 766
Score = 34.7 bits (78), Expect = 0.094
Identities = 44/189 (23%), Positives = 88/189 (46%), Gaps = 20/189 (10%)
Query: 98 SSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQL 157
S +K++LQA + + + ++Q + + + A+ ++ E +AQL ++ L++QL
Sbjct: 1217 SEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQL 1276
Query: 158 SE--------PDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQL 209
S+ + + +K RE+ Q L L ++ E G+ + Q K EL
Sbjct: 1277 SKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELE-GLQQLLQNVKSEL--- 1332
Query: 210 IEQAQK-LTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPKTTPSLP 268
E AQ+ L+ TQ + ++ + + +++L+Q Q+L+ L+ + T P
Sbjct: 1333 -EMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLK------LDLRRGAAKTRKEP 1385
Query: 269 QGTKSRINP 277
+G S NP
Sbjct: 1386 KGEASSSNP 1394
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.125 0.327
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,008,619
Number of Sequences: 37866
Number of extensions: 381061
Number of successful extensions: 6954
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 281
Number of HSP's successfully gapped in prelim test: 829
Number of HSP's that attempted gapping in prelim test: 3172
Number of HSP's gapped (non-prelim): 2909
length of query: 278
length of database: 18,247,518
effective HSP length: 101
effective length of query: 177
effective length of database: 14,423,052
effective search space: 2552880204
effective search space used: 2552880204
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.