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Search of human proteins with 39777604
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
(879 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 1751 0.0
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 1734 0.0
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 1734 0.0
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 483 e-136
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 413 e-115
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 413 e-115
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 189 1e-47
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 189 1e-47
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 189 1e-47
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 181 3e-45
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 177 3e-44
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor... 168 2e-41
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor... 168 2e-41
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor... 168 2e-41
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens] 150 4e-36
gi|38373682 pleckstrin homology domain containing family G membe... 136 7e-32
gi|111154084 pleckstrin homology domain containing family G memb... 136 7e-32
gi|111154088 pleckstrin homology domain containing family G memb... 136 7e-32
gi|111154080 pleckstrin homology domain containing family G memb... 136 7e-32
gi|111154078 pleckstrin homology domain containing family G memb... 136 7e-32
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 114 3e-25
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 114 3e-25
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 111 3e-24
gi|222080070 pleckstrin homology domain-containing family G memb... 103 9e-22
gi|222080068 pleckstrin homology domain-containing family G memb... 103 9e-22
gi|222080066 pleckstrin homology domain-containing family G memb... 103 9e-22
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 84 4e-16
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [... 84 4e-16
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 83 1e-15
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 82 2e-15
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
Length = 879
Score = 1751 bits (4535), Expect = 0.0
Identities = 879/879 (100%), Positives = 879/879 (100%)
Query: 1 MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM 60
MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM
Sbjct: 1 MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM 60
Query: 61 ALLQHVALQFEPGPLVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQ 120
ALLQHVALQFEPGPLVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQ
Sbjct: 61 ALLQHVALQFEPGPLVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQ 120
Query: 121 LEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEE 180
LEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEE
Sbjct: 121 LEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEE 180
Query: 181 KSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAAR 240
KSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAAR
Sbjct: 181 KSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAAR 240
Query: 241 WNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDS 300
WNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDS
Sbjct: 241 WNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDS 300
Query: 301 PDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPE 360
PDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPE
Sbjct: 301 PDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPE 360
Query: 361 EPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFP 420
EPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFP
Sbjct: 361 EPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFP 420
Query: 421 LEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS 480
LEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS
Sbjct: 421 LEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS 480
Query: 481 RFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQ 540
RFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQ
Sbjct: 481 RFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQ 540
Query: 541 SIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDP 600
SIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDP
Sbjct: 541 SIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDP 600
Query: 601 MLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRT 660
MLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRT
Sbjct: 601 MLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRT 660
Query: 661 LTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCA 720
LTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCA
Sbjct: 661 LTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCA 720
Query: 721 LITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLP 780
LITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLP
Sbjct: 721 LITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLP 780
Query: 781 FCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQEN 840
FCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQEN
Sbjct: 781 FCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQEN 840
Query: 841 LLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT 879
LLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT
Sbjct: 841 LLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT 879
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
[Homo sapiens]
Length = 927
Score = 1734 bits (4491), Expect = 0.0
Identities = 879/912 (96%), Positives = 879/912 (96%), Gaps = 33/912 (3%)
Query: 1 MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM 60
MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM
Sbjct: 16 MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM 75
Query: 61 ALLQHVALQFEPGPL---------------------------------VLRVPVPPNVAF 87
ALLQHVALQFEPGPL VLRVPVPPNVAF
Sbjct: 76 ALLQHVALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAF 135
Query: 88 ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG 147
ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG
Sbjct: 136 ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG 195
Query: 148 RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKS 207
RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKS
Sbjct: 196 RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKS 255
Query: 208 GRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATD 267
GRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATD
Sbjct: 256 GRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATD 315
Query: 268 RKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL 327
RKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL
Sbjct: 316 RKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL 375
Query: 328 APPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEV 387
APPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEV
Sbjct: 376 APPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEV 435
Query: 388 ISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMK 447
ISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMK
Sbjct: 436 ISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMK 495
Query: 448 RRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV 507
RRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV
Sbjct: 496 RRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV 555
Query: 508 QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILH 567
QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILH
Sbjct: 556 QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILH 615
Query: 568 HVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTK 627
HVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTK
Sbjct: 616 HVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTK 675
Query: 628 DKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT 687
DKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT
Sbjct: 676 DKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT 735
Query: 688 DHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSST 747
DHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSST
Sbjct: 736 DHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSST 795
Query: 748 REPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFP 807
REPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFP
Sbjct: 796 REPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFP 855
Query: 808 AEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQ 867
AEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQ
Sbjct: 856 AEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQ 915
Query: 868 LGGNSVPQPGCT 879
LGGNSVPQPGCT
Sbjct: 916 LGGNSVPQPGCT 927
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
[Homo sapiens]
Length = 912
Score = 1734 bits (4491), Expect = 0.0
Identities = 879/912 (96%), Positives = 879/912 (96%), Gaps = 33/912 (3%)
Query: 1 MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM 60
MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM
Sbjct: 1 MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM 60
Query: 61 ALLQHVALQFEPGPL---------------------------------VLRVPVPPNVAF 87
ALLQHVALQFEPGPL VLRVPVPPNVAF
Sbjct: 61 ALLQHVALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAF 120
Query: 88 ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG 147
ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG
Sbjct: 121 ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG 180
Query: 148 RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKS 207
RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKS
Sbjct: 181 RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKS 240
Query: 208 GRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATD 267
GRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATD
Sbjct: 241 GRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATD 300
Query: 268 RKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL 327
RKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL
Sbjct: 301 RKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL 360
Query: 328 APPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEV 387
APPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEV
Sbjct: 361 APPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEV 420
Query: 388 ISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMK 447
ISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMK
Sbjct: 421 ISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMK 480
Query: 448 RRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV 507
RRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV
Sbjct: 481 RRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV 540
Query: 508 QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILH 567
QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILH
Sbjct: 541 QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILH 600
Query: 568 HVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTK 627
HVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTK
Sbjct: 601 HVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTK 660
Query: 628 DKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT 687
DKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT
Sbjct: 661 DKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT 720
Query: 688 DHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSST 747
DHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSST
Sbjct: 721 DHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSST 780
Query: 748 REPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFP 807
REPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFP
Sbjct: 781 REPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFP 840
Query: 808 AEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQ 867
AEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQ
Sbjct: 841 AEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQ 900
Query: 868 LGGNSVPQPGCT 879
LGGNSVPQPGCT
Sbjct: 901 LGGNSVPQPGCT 912
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 483 bits (1242), Expect = e-136
Identities = 312/811 (38%), Positives = 460/811 (56%), Gaps = 100/811 (12%)
Query: 23 IIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLV------ 76
IIGAED+DF E E Q S FQS+E +K RPAHL L HV QF+P L+
Sbjct: 350 IIGAEDDDFGTEHE-QINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSD 408
Query: 77 ---------------------------LRVPVPPNVAFELDRTRADLISEDVQRRFVQEV 109
L+V VP ++ +L++ R +LI ED+ R ++Q +
Sbjct: 409 LYKHTNSKETRRIFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTM 468
Query: 110 VQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLE 169
+ V R LEDFR KR MG+T E EL +L+A +DR + E +ER AE+++ +E
Sbjct: 469 QERVHPEVQRHLEDFRQKRSMGLTLAESELTKLDAERDKDRLTLE-KERTCAEQIVAKIE 527
Query: 170 EMQHTI-STDEEKSAAVVNAIGLYMRHLGVRTKSG---DKKSGRNFFRKKVMGNRRSDEP 225
E+ T + +E+KS+ + I +YM+HLGV+ K + K GR F K+ + + D+
Sbjct: 528 EVLMTAQAVEEDKSSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDKE 587
Query: 226 AKTK---KGLSSILDAARWNRGEPQVPDFRHLKAEVD-------AEKPGATDRKGGVGMP 275
+ K +G SIL G P+ P RH + + A P V
Sbjct: 588 GEEKGKRRGFPSIL-------GPPRRPS-RHDNSAIGRAMELQKARHPKHLSTPSSVSPE 639
Query: 276 SRD----RNIGAPGQDTPGVSLHPLSLDSP------DREPGAD---APLELGDSSPQG-- 320
+D R G + T L S+ S +E G + ++G++S G
Sbjct: 640 PQDSAKLRQSGLANEGTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDT 699
Query: 321 ----PMSLESLA--PPESTDEGAETE----------SPEPGDE------GEPGRSGLELE 358
P +L ++ PP D+ E E +P+P + GE + E
Sbjct: 700 LDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFE 759
Query: 359 PE---EPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAE 415
+ +PP W++LV + L L ++KRQEVI+EL TE AHVR L+VL +F+Q ++
Sbjct: 760 NDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSR 819
Query: 416 CLFFPLEELQNIFPSLDELIEVHSLFLDRLMK--RRQESGYLIEEIGDVLLARFDGAEGS 473
EL+ IF +L++++++H + L+ MK R++ +I++IG+ LL F G
Sbjct: 820 EGILSPSELRKIFSNLEDILQLH-IGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEE 878
Query: 474 WFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLT 533
+ ++ FCS Q FALE +K++Q+KD RF FVQ+AES P CRRLQLKD+IPT+MQRLT
Sbjct: 879 KLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLT 938
Query: 534 KYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSH 593
KYPLLL +I + TE PTEREKV+ AA+ CR+IL++VNQAV++ E+ RL+DYQRRLD S
Sbjct: 939 KYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSS 998
Query: 594 LRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLL 653
L+ S P + E +NLD+TK+K++HEGPL W+V +DK ++++ LLL+D+L+LLQ+QD+RL+
Sbjct: 999 LKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLV 1058
Query: 654 LKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVS 713
L+ HS+ L T D K PV++L++ + R+VATD+KA +V+ D AQIYELVAQTVS
Sbjct: 1059 LRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVS 1118
Query: 714 ERKNWCALITETAGSLKVPAPASRPKPRPSP 744
E+ W LI A S+K + P P+ +P
Sbjct: 1119 EKTVWQDLICRMAASVKEQSTKPIPLPQSTP 1149
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 413 bits (1062), Expect = e-115
Identities = 321/914 (35%), Positives = 470/914 (51%), Gaps = 138/914 (15%)
Query: 8 AASPGPSRPGL--VPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQH 65
AA P G+ P +I +ED++ N E + FQ LE++K RPAHL L++
Sbjct: 313 AAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNN--ESDIIFQDLEKLKSRPAHLGVFLRY 370
Query: 66 VALQFEPGPLV---------------------------------LRVPVPPNVAFELDRT 92
+ Q +P PL+ LRV +P + E+D
Sbjct: 371 IFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSR 430
Query: 93 RADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPW--EQELAQLEAWVGRDR 150
+ SED R + E ++ + Q+ D+R+KR +G+ E +L L+
Sbjct: 431 LRN--SEDA-RGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDG------ 481
Query: 151 ASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSG------- 203
RER VAE+ L L ++ +E++SA + A+ YM H G+R +
Sbjct: 482 --DPLRERQVAEKQLAALGDILSKY--EEDRSAPMDFALNTYMSHAGIRLREARPSNTAE 537
Query: 204 ------DKKSGRNFFRK-KVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQ----VP--- 249
DK FF K K N + ++ A K + IL + Q +P
Sbjct: 538 KAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSP 597
Query: 250 ------DFRHL------KAEVDAEKPGATDRKGGVGMP--------SRD-----RNIGAP 284
+ R++ + DA +PG T R P SR R+
Sbjct: 598 VEVKPGNVRNIIQHFENNQQYDAPEPG-TQRLSTGSFPEDLLESDSSRSEIRLGRSESLK 656
Query: 285 GQDTPGVSLH----PLSLDSPDREPGADAP-LELGDSSPQGPMSLESL---APPESTDEG 336
G++ S P S D + A+A L SS +S SL PP + G
Sbjct: 657 GREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMG 716
Query: 337 AET-ESPEPGD----------EGEPGRSGLELEPE-EPPGWRELVPPDTLHSLPKSQVKR 384
+ ESP G E + G+ +LEPE + W+ V D + L + ++ R
Sbjct: 717 RRSIESPSLGFCTDTLLPHLLEDDLGQLS-DLEPEPDAQNWQHTVGKDVVAGLTQREIDR 775
Query: 385 QEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDR 444
QEVI+EL VTEA+H+R LRVL +F+Q M + P EEL +FP+L ELIE+H+ + +
Sbjct: 776 QEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA 835
Query: 445 LMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFC 504
+ K R+E G +I+EI D++LARFDG Q+++++FCS QS ALE +K KQRK+ RF
Sbjct: 836 MKKLREE-GPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQ 894
Query: 505 AFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPT-EREKVELAAECCR 563
F+QEAES P+CRRLQL+D+I +EMQRLTKYPLLL+SI ++TE T E EK+ A + CR
Sbjct: 895 LFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCR 954
Query: 564 EILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623
EIL +VN+AV+ E+ RL+ YQ+RLD + L ++S+P+ +EFK+LD+T +K++HEGPLTW
Sbjct: 955 EILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTW 1014
Query: 624 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683
R++KDK +++HVLLL+DLL+LLQ+QDE+LLLK HS+T + D K PVL+L + + R
Sbjct: 1015 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1074
Query: 684 EVATDHKAFYVLFTWD-QEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKP-R 741
VATD +AF+++ T QIYELVA T S++ W L+ E + P + P P
Sbjct: 1075 SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN-ATRHPGAAPMPVH 1133
Query: 742 PSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAAT-ALRKVLS 800
P P REP + P +R E SD+ P PE T + ++V
Sbjct: 1134 PPPPGPREP-----------AQQGPTPSRVELDDSDVF-HGEPEPEELPGGTGSQQRVQG 1181
Query: 801 LKQLLFPAEEDNGA 814
Q+L E G+
Sbjct: 1182 KHQVLLEDPEQEGS 1195
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 413 bits (1062), Expect = e-115
Identities = 321/914 (35%), Positives = 470/914 (51%), Gaps = 138/914 (15%)
Query: 8 AASPGPSRPGL--VPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQH 65
AA P G+ P +I +ED++ N E + FQ LE++K RPAHL L++
Sbjct: 273 AAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNN--ESDIIFQDLEKLKSRPAHLGVFLRY 330
Query: 66 VALQFEPGPLV---------------------------------LRVPVPPNVAFELDRT 92
+ Q +P PL+ LRV +P + E+D
Sbjct: 331 IFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSR 390
Query: 93 RADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPW--EQELAQLEAWVGRDR 150
+ SED R + E ++ + Q+ D+R+KR +G+ E +L L+
Sbjct: 391 LRN--SEDA-RGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDG------ 441
Query: 151 ASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSG------- 203
RER VAE+ L L ++ +E++SA + A+ YM H G+R +
Sbjct: 442 --DPLRERQVAEKQLAALGDILSKY--EEDRSAPMDFALNTYMSHAGIRLREARPSNTAE 497
Query: 204 ------DKKSGRNFFRK-KVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQ----VP--- 249
DK FF K K N + ++ A K + IL + Q +P
Sbjct: 498 KAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSP 557
Query: 250 ------DFRHL------KAEVDAEKPGATDRKGGVGMP--------SRD-----RNIGAP 284
+ R++ + DA +PG T R P SR R+
Sbjct: 558 VEVKPGNVRNIIQHFENNQQYDAPEPG-TQRLSTGSFPEDLLESDSSRSEIRLGRSESLK 616
Query: 285 GQDTPGVSLH----PLSLDSPDREPGADAP-LELGDSSPQGPMSLESL---APPESTDEG 336
G++ S P S D + A+A L SS +S SL PP + G
Sbjct: 617 GREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMG 676
Query: 337 AET-ESPEPGD----------EGEPGRSGLELEPE-EPPGWRELVPPDTLHSLPKSQVKR 384
+ ESP G E + G+ +LEPE + W+ V D + L + ++ R
Sbjct: 677 RRSIESPSLGFCTDTLLPHLLEDDLGQLS-DLEPEPDAQNWQHTVGKDVVAGLTQREIDR 735
Query: 385 QEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDR 444
QEVI+EL VTEA+H+R LRVL +F+Q M + P EEL +FP+L ELIE+H+ + +
Sbjct: 736 QEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA 795
Query: 445 LMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFC 504
+ K R+E G +I+EI D++LARFDG Q+++++FCS QS ALE +K KQRK+ RF
Sbjct: 796 MKKLREE-GPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQ 854
Query: 505 AFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPT-EREKVELAAECCR 563
F+QEAES P+CRRLQL+D+I +EMQRLTKYPLLL+SI ++TE T E EK+ A + CR
Sbjct: 855 LFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCR 914
Query: 564 EILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623
EIL +VN+AV+ E+ RL+ YQ+RLD + L ++S+P+ +EFK+LD+T +K++HEGPLTW
Sbjct: 915 EILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTW 974
Query: 624 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683
R++KDK +++HVLLL+DLL+LLQ+QDE+LLLK HS+T + D K PVL+L + + R
Sbjct: 975 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1034
Query: 684 EVATDHKAFYVLFTWD-QEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKP-R 741
VATD +AF+++ T QIYELVA T S++ W L+ E + P + P P
Sbjct: 1035 SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN-ATRHPGAAPMPVH 1093
Query: 742 PSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAAT-ALRKVLS 800
P P REP + P +R E SD+ P PE T + ++V
Sbjct: 1094 PPPPGPREP-----------AQQGPTPSRVELDDSDVF-HGEPEPEELPGGTGSQQRVQG 1141
Query: 801 LKQLLFPAEEDNGA 814
Q+L E G+
Sbjct: 1142 KHQVLLEDPEQEGS 1155
>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
Length = 2817
Score = 189 bits (480), Expect = 1e-47
Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)
Query: 333 TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 392
TDEG T+ E G+ +LE E W ++ L K VKRQEVI EL+
Sbjct: 1951 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 2007
Query: 393 VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 452
TE HVR L+++ ++ Q M L F + ++ +FP LDELI +HS F R+++R++ES
Sbjct: 2008 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 2067
Query: 453 -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 505
+LI+ IGDVL+ +F G +K +FC + + ++ K KD RF A
Sbjct: 2068 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 2127
Query: 506 FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 564
FV++ S RRL + + I QR+TKYP+L Q I Q T++ E+E + + ++
Sbjct: 2128 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 2187
Query: 565 ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623
++ V+ V E +RL + + D S +R S M F D+ +KKLV +G +
Sbjct: 2188 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 2244
Query: 624 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683
+ + EV +LL D+L+ LQ +D++ + S + T V+ L + R
Sbjct: 2245 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 2293
Query: 684 EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 729
EVA + K +++ + ++ E+ A + ER +W +I +T +L
Sbjct: 2294 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2339
>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
Length = 1058
Score = 189 bits (480), Expect = 1e-47
Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)
Query: 333 TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 392
TDEG T+ E G+ +LE E W ++ L K VKRQEVI EL+
Sbjct: 192 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 248
Query: 393 VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 452
TE HVR L+++ ++ Q M L F + ++ +FP LDELI +HS F R+++R++ES
Sbjct: 249 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 308
Query: 453 -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 505
+LI+ IGDVL+ +F G +K +FC + + ++ K KD RF A
Sbjct: 309 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 368
Query: 506 FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 564
FV++ S RRL + + I QR+TKYP+L Q I Q T++ E+E + + ++
Sbjct: 369 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 428
Query: 565 ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623
++ V+ V E +RL + + D S +R S M F D+ +KKLV +G +
Sbjct: 429 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 485
Query: 624 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683
+ + EV +LL D+L+ LQ +D++ + S + T V+ L + R
Sbjct: 486 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 534
Query: 684 EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 729
EVA + K +++ + ++ E+ A + ER +W +I +T +L
Sbjct: 535 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 580
>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
Length = 2813
Score = 189 bits (480), Expect = 1e-47
Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)
Query: 333 TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 392
TDEG T+ E G+ +LE E W ++ L K VKRQEVI EL+
Sbjct: 1947 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 2003
Query: 393 VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 452
TE HVR L+++ ++ Q M L F + ++ +FP LDELI +HS F R+++R++ES
Sbjct: 2004 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 2063
Query: 453 -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 505
+LI+ IGDVL+ +F G +K +FC + + ++ K KD RF A
Sbjct: 2064 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 2123
Query: 506 FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 564
FV++ S RRL + + I QR+TKYP+L Q I Q T++ E+E + + ++
Sbjct: 2124 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 2183
Query: 565 ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623
++ V+ V E +RL + + D S +R S M F D+ +KKLV +G +
Sbjct: 2184 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 2240
Query: 624 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683
+ + EV +LL D+L+ LQ +D++ + S + T V+ L + R
Sbjct: 2241 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 2289
Query: 684 EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 729
EVA + K +++ + ++ E+ A + ER +W +I +T +L
Sbjct: 2290 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2335
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform
b [Homo sapiens]
Length = 1173
Score = 181 bits (458), Expect = 3e-45
Identities = 168/608 (27%), Positives = 270/608 (44%), Gaps = 76/608 (12%)
Query: 273 GMPSRDRNIG-----------APGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGP 321
G P+ RN+G P PG L P++ + + + + D S
Sbjct: 149 GSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSL--- 205
Query: 322 MSLESLAPPESTDEGAETESPEPGD-EGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKS 380
SL P + E E P E G E E E W V +
Sbjct: 206 ----SLTSPNT--ESIFVEDPYTASLRSEIESDGHEFEAES---WSLAVDAAYAKKQKRE 256
Query: 381 QVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSL 440
VKRQ+V+ EL+ TE HVR L+++ ++ + + E L F + + +FP D+L+E HS
Sbjct: 257 VVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSH 316
Query: 441 FLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQL 493
FL RL +RRQES Y+I++IGD+L+ +F G G ++ FCS + A+
Sbjct: 317 FLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHY 376
Query: 494 KAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTE-R 552
K +++ +F +++ + RRL +++ I QR+TKYP+L++ I QNTE TE
Sbjct: 377 KLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDY 436
Query: 553 EKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITK 612
E + A ++I+ V+ V + E RL++ ++DL + + + F+ D+ +
Sbjct: 437 EDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGL--TFRKEDMLQ 494
Query: 613 KKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLR 672
++L EG L W+ T + ++ +LL D+LLLLQ +D++ + S D K
Sbjct: 495 RQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFAS--------VDSKP--- 543
Query: 673 PVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVP 732
PV+ L + REVA + KA +++ Q ++YE+ + +R W A I
Sbjct: 544 PVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQR-------- 595
Query: 733 APASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAA 792
A S P P S E E +AR R L D R + QL A
Sbjct: 596 AVESCPDEEEGPFSLPE------------EERKVVEARATR-LRDFQE--RLSMKDQLIA 640
Query: 793 TALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLE 852
+L L +Q+ E G G+ GG S E + L L+ M ++E
Sbjct: 641 QSL---LEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPS-----ETLQGELILKSAMSEIE 692
Query: 853 ELEEEFCR 860
++ CR
Sbjct: 693 GIQSLICR 700
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 177 bits (450), Expect = 3e-44
Identities = 155/545 (28%), Positives = 250/545 (45%), Gaps = 56/545 (10%)
Query: 325 ESLAPPESTDEGAETESPEPGD-EGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVK 383
+SL+ E E P E G E E E W V + VK
Sbjct: 45 DSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAES---WSLAVDAAYAKKQKREVVK 101
Query: 384 RQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLD 443
RQ+V+ EL+ TE HVR L+++ ++ + + E L F + + +FP D+L+E HS FL
Sbjct: 102 RQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLA 161
Query: 444 RLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAK 496
RL +RRQES Y+I++IGD+L+ +F G G ++ FCS + A+ K
Sbjct: 162 RLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLL 221
Query: 497 QRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTE-REKV 555
+++ +F +++ + RRL +++ I QR+TKYP+L++ I QNTE TE E +
Sbjct: 222 LQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDL 281
Query: 556 ELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKL 615
A ++I+ V+ V + E RL++ ++DL + + + F+ D+ +++L
Sbjct: 282 TQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGL--TFRKEDMLQRQL 339
Query: 616 VHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVL 675
EG L W+ T + ++ +LL D+LLLLQ +D++ + S D K PV+
Sbjct: 340 HLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFAS--------VDSKP---PVI 388
Query: 676 RLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPA 735
L + REVA + KA +++ Q ++YE+ + +R W A I A
Sbjct: 389 SLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQR--------AVE 440
Query: 736 SRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATAL 795
S P P S E E +AR R L D R + QL A +L
Sbjct: 441 SCPDEEEGPFSLPE------------EERKVVEARATR-LRDFQE--RLSMKDQLIAQSL 485
Query: 796 RKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELE 855
L +Q+ E G G+ GG S E + L L+ M ++E ++
Sbjct: 486 ---LEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPS-----ETLQGELILKSAMSEIEGIQ 537
Query: 856 EEFCR 860
CR
Sbjct: 538 SLICR 542
>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
[Homo sapiens]
Length = 985
Score = 168 bits (425), Expect = 2e-41
Identities = 142/528 (26%), Positives = 245/528 (46%), Gaps = 65/528 (12%)
Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
W V L K +K+Q+VI EL+ TE HVR L+++ LF M E L +
Sbjct: 216 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 275
Query: 425 QNIFPSLDELIEVHSLFLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQK 477
Q +FP +DEL ++H+ FL +L++RR+++ ++I +GD+L+++F G K
Sbjct: 276 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 335
Query: 478 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 537
S FCSR S AL+ K +D RF F+++ +R +++ I QR+TKYPL
Sbjct: 336 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 395
Query: 538 LLQSIGQNTEE-PTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQ 596
L+ I Q++ ER+ + A +E+L +V++ + +E RL++ R+D Q
Sbjct: 396 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD--PRAQ 453
Query: 597 SSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKS 656
+ P F ++ ++KL+H+G L W+ + +V VLL+ D+L+ LQ +D++ +
Sbjct: 454 TPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIF-- 511
Query: 657 HSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERK 716
PT D + V+ L + + R++A K +++ E +YE+ + +R
Sbjct: 512 ------PTLDKPS----VVSLQNLIVRDIANQEKGMFLISAAPPE--MYEVHTASRDDRS 559
Query: 717 NWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILS 776
W +I ++ R PS PL+ + + +A RI
Sbjct: 560 TWIRVIQQSV--------------RTCPSREDFPLIETED-----------EAYLRRIKM 594
Query: 777 DLLPFCRPGPEGQLAATALRKVLSL--KQLLFPAEEDNGAGP--PRDGDGVPGGGPLSPA 832
+L + + LR+ + L + F AEED G+G P G+ L
Sbjct: 595 EL------QQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESP 648
Query: 833 RTQEIQENLLSLEETMKQL------EELEEEFCRLRPLLSQLGGNSVP 874
R + + ++ + E +K L E L PL GGN+ P
Sbjct: 649 RGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSP 696
>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
[Homo sapiens]
Length = 986
Score = 168 bits (425), Expect = 2e-41
Identities = 142/528 (26%), Positives = 245/528 (46%), Gaps = 65/528 (12%)
Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
W V L K +K+Q+VI EL+ TE HVR L+++ LF M E L +
Sbjct: 217 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 276
Query: 425 QNIFPSLDELIEVHSLFLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQK 477
Q +FP +DEL ++H+ FL +L++RR+++ ++I +GD+L+++F G K
Sbjct: 277 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 336
Query: 478 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 537
S FCSR S AL+ K +D RF F+++ +R +++ I QR+TKYPL
Sbjct: 337 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 396
Query: 538 LLQSIGQNTEE-PTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQ 596
L+ I Q++ ER+ + A +E+L +V++ + +E RL++ R+D Q
Sbjct: 397 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD--PRAQ 454
Query: 597 SSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKS 656
+ P F ++ ++KL+H+G L W+ + +V VLL+ D+L+ LQ +D++ +
Sbjct: 455 TPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIF-- 512
Query: 657 HSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERK 716
PT D + V+ L + + R++A K +++ E +YE+ + +R
Sbjct: 513 ------PTLDKPS----VVSLQNLIVRDIANQEKGMFLISAAPPE--MYEVHTASRDDRS 560
Query: 717 NWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILS 776
W +I ++ R PS PL+ + + +A RI
Sbjct: 561 TWIRVIQQSV--------------RTCPSREDFPLIETED-----------EAYLRRIKM 595
Query: 777 DLLPFCRPGPEGQLAATALRKVLSL--KQLLFPAEEDNGAGP--PRDGDGVPGGGPLSPA 832
+L + + LR+ + L + F AEED G+G P G+ L
Sbjct: 596 EL------QQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESP 649
Query: 833 RTQEIQENLLSLEETMKQL------EELEEEFCRLRPLLSQLGGNSVP 874
R + + ++ + E +K L E L PL GGN+ P
Sbjct: 650 RGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSP 697
>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
[Homo sapiens]
Length = 958
Score = 168 bits (425), Expect = 2e-41
Identities = 142/528 (26%), Positives = 245/528 (46%), Gaps = 65/528 (12%)
Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
W V L K +K+Q+VI EL+ TE HVR L+++ LF M E L +
Sbjct: 189 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 248
Query: 425 QNIFPSLDELIEVHSLFLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQK 477
Q +FP +DEL ++H+ FL +L++RR+++ ++I +GD+L+++F G K
Sbjct: 249 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 308
Query: 478 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 537
S FCSR S AL+ K +D RF F+++ +R +++ I QR+TKYPL
Sbjct: 309 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 368
Query: 538 LLQSIGQNTEE-PTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQ 596
L+ I Q++ ER+ + A +E+L +V++ + +E RL++ R+D Q
Sbjct: 369 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD--PRAQ 426
Query: 597 SSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKS 656
+ P F ++ ++KL+H+G L W+ + +V VLL+ D+L+ LQ +D++ +
Sbjct: 427 TPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIF-- 484
Query: 657 HSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERK 716
PT D + V+ L + + R++A K +++ E +YE+ + +R
Sbjct: 485 ------PTLDKPS----VVSLQNLIVRDIANQEKGMFLISAAPPE--MYEVHTASRDDRS 532
Query: 717 NWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILS 776
W +I ++ R PS PL+ + + +A RI
Sbjct: 533 TWIRVIQQSV--------------RTCPSREDFPLIETED-----------EAYLRRIKM 567
Query: 777 DLLPFCRPGPEGQLAATALRKVLSL--KQLLFPAEEDNGAGP--PRDGDGVPGGGPLSPA 832
+L + + LR+ + L + F AEED G+G P G+ L
Sbjct: 568 EL------QQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESP 621
Query: 833 RTQEIQENLLSLEETMKQL------EELEEEFCRLRPLLSQLGGNSVP 874
R + + ++ + E +K L E L PL GGN+ P
Sbjct: 622 RGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSP 669
>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
Length = 1651
Score = 150 bits (380), Expect = 4e-36
Identities = 130/522 (24%), Positives = 231/522 (44%), Gaps = 47/522 (9%)
Query: 225 PAKTKKGLSSILDAARWNRGEPQV----PDFRHLKAEVDAEKPGATDRKGG---VGMPSR 277
PA TKK ++N+ +PQ FR D +PG + VG+P+
Sbjct: 697 PACTKKFQE------KYNKNKPQTILGNSSFR------DIPQPGLSLHPSSSVPVGLPTG 744
Query: 278 DRN----IGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPEST 333
R + + PG +L + E +D S L+S+ ST
Sbjct: 745 RRETVGQVHPLSRSVPGTTLESFRRSATSLESESDH--NSCRSRSHSDELLQSMGSSPST 802
Query: 334 DEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLV 393
+ + + + E E E W +V P + K +KRQ+VI EL+
Sbjct: 803 ESFIMEDVVDSSLWSDLSSDAQEFEAES---WSLVVDPSFCNRQEKDVIKRQDVIFELMQ 859
Query: 394 TEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES- 452
TE H++ L ++ ++F + M E L + IFP LDEL+E+H F + +RRQES
Sbjct: 860 TEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESC 919
Query: 453 -----GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV 507
++I+ IGD+L+ +F S +KI FC A+ K Q ++ +F F+
Sbjct: 920 AGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQ-QNKKFQNFI 978
Query: 508 QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAEC-CREIL 566
+ S RR + + I QR+TKYP+L++ I Q T+E TE K A C ++++
Sbjct: 979 KLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMI 1038
Query: 567 HHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVT 626
V+ V + E + + +++ + + + + L ++ L+++G + W+
Sbjct: 1039 ATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTA 1098
Query: 627 KDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVA 686
+ ++ LLL D+LL LQ +D++ + + + + V+ L + REVA
Sbjct: 1099 TGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPS-----------VISLQKLIAREVA 1147
Query: 687 TDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGS 728
+ + +++ ++YE+ + ER NW I + S
Sbjct: 1148 NEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVES 1189
>gi|38373682 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 136 bits (343), Expect = 7e-32
Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%)
Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 423
WREL+ D L + Q +QE + ELL TEA+++R LRV+ +LF C L+E
Sbjct: 320 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 372
Query: 424 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 471
+ +F ++ E+ ++H S+ L K R+ L + GD L +
Sbjct: 373 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 428
Query: 472 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 531
GS F K R+C + +E ++ R + F A++ AE P+C+RL+L DM+ QR
Sbjct: 429 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 487
Query: 532 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
LTKYPLLL+S+ + TEEP +E V +HHVN +R ++ RL R+D
Sbjct: 488 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 547
Query: 592 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 637
+ +SS D +L EF +LD+T ++L+ EG L + KD ++V+ L
Sbjct: 548 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 607
Query: 638 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 697
DLLL+ + +K RT ++RP L + + RE+ D +F +++
Sbjct: 608 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 652
Query: 698 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 755
+ + + Y A + + W I L + P +++PL S
Sbjct: 653 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 705
Query: 756 ENGNGGRETSPADARTE 772
E + E + E
Sbjct: 706 EEEDEQEEEEEEEEEEE 722
>gi|111154084 pleckstrin homology domain containing family G member
5 isoform b [Homo sapiens]
Length = 1083
Score = 136 bits (343), Expect = 7e-32
Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%)
Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 423
WREL+ D L + Q +QE + ELL TEA+++R LRV+ +LF C L+E
Sbjct: 397 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 449
Query: 424 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 471
+ +F ++ E+ ++H S+ L K R+ L + GD L +
Sbjct: 450 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 505
Query: 472 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 531
GS F K R+C + +E ++ R + F A++ AE P+C+RL+L DM+ QR
Sbjct: 506 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 564
Query: 532 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
LTKYPLLL+S+ + TEEP +E V +HHVN +R ++ RL R+D
Sbjct: 565 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 624
Query: 592 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 637
+ +SS D +L EF +LD+T ++L+ EG L + KD ++V+ L
Sbjct: 625 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 684
Query: 638 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 697
DLLL+ + +K RT ++RP L + + RE+ D +F +++
Sbjct: 685 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 729
Query: 698 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 755
+ + + Y A + + W I L + P +++PL S
Sbjct: 730 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 782
Query: 756 ENGNGGRETSPADARTE 772
E + E + E
Sbjct: 783 EEEDEQEEEEEEEEEEE 799
>gi|111154088 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 136 bits (343), Expect = 7e-32
Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%)
Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 423
WREL+ D L + Q +QE + ELL TEA+++R LRV+ +LF C L+E
Sbjct: 320 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 372
Query: 424 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 471
+ +F ++ E+ ++H S+ L K R+ L + GD L +
Sbjct: 373 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 428
Query: 472 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 531
GS F K R+C + +E ++ R + F A++ AE P+C+RL+L DM+ QR
Sbjct: 429 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 487
Query: 532 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
LTKYPLLL+S+ + TEEP +E V +HHVN +R ++ RL R+D
Sbjct: 488 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 547
Query: 592 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 637
+ +SS D +L EF +LD+T ++L+ EG L + KD ++V+ L
Sbjct: 548 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 607
Query: 638 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 697
DLLL+ + +K RT ++RP L + + RE+ D +F +++
Sbjct: 608 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 652
Query: 698 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 755
+ + + Y A + + W I L + P +++PL S
Sbjct: 653 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 705
Query: 756 ENGNGGRETSPADARTE 772
E + E + E
Sbjct: 706 EEEDEQEEEEEEEEEEE 722
>gi|111154080 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 136 bits (343), Expect = 7e-32
Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%)
Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 423
WREL+ D L + Q +QE + ELL TEA+++R LRV+ +LF C L+E
Sbjct: 320 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 372
Query: 424 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 471
+ +F ++ E+ ++H S+ L K R+ L + GD L +
Sbjct: 373 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 428
Query: 472 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 531
GS F K R+C + +E ++ R + F A++ AE P+C+RL+L DM+ QR
Sbjct: 429 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 487
Query: 532 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
LTKYPLLL+S+ + TEEP +E V +HHVN +R ++ RL R+D
Sbjct: 488 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 547
Query: 592 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 637
+ +SS D +L EF +LD+T ++L+ EG L + KD ++V+ L
Sbjct: 548 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 607
Query: 638 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 697
DLLL+ + +K RT ++RP L + + RE+ D +F +++
Sbjct: 608 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 652
Query: 698 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 755
+ + + Y A + + W I L + P +++PL S
Sbjct: 653 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 705
Query: 756 ENGNGGRETSPADARTE 772
E + E + E
Sbjct: 706 EEEDEQEEEEEEEEEEE 722
>gi|111154078 pleckstrin homology domain containing family G member
5 isoform c [Homo sapiens]
Length = 1062
Score = 136 bits (343), Expect = 7e-32
Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%)
Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 423
WREL+ D L + Q +QE + ELL TEA+++R LRV+ +LF C L+E
Sbjct: 376 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 428
Query: 424 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 471
+ +F ++ E+ ++H S+ L K R+ L + GD L +
Sbjct: 429 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 484
Query: 472 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 531
GS F K R+C + +E ++ R + F A++ AE P+C+RL+L DM+ QR
Sbjct: 485 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 543
Query: 532 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
LTKYPLLL+S+ + TEEP +E V +HHVN +R ++ RL R+D
Sbjct: 544 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 603
Query: 592 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 637
+ +SS D +L EF +LD+T ++L+ EG L + KD ++V+ L
Sbjct: 604 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 663
Query: 638 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 697
DLLL+ + +K RT ++RP L + + RE+ D +F +++
Sbjct: 664 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 708
Query: 698 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 755
+ + + Y A + + W I L + P +++PL S
Sbjct: 709 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 761
Query: 756 ENGNGGRETSPADARTE 772
E + E + E
Sbjct: 762 EEEDEQEEEEEEEEEEE 778
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 114 bits (286), Expect = 3e-25
Identities = 94/367 (25%), Positives = 172/367 (46%), Gaps = 15/367 (4%)
Query: 355 LELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMA 414
+++ + P + TL ++ + KRQ I EL+ TE ++ L+++ ++F + MA
Sbjct: 1154 VKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1213
Query: 415 ECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEG 472
E F E+ IF + ELI ++ L L R++ G ++ IGD+L A +
Sbjct: 1214 ESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA 1273
Query: 473 SWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRL 532
RFCS Q L+ K +D F F+++ S PRC+ + L + MQR+
Sbjct: 1274 Y------IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRI 1327
Query: 533 TKYPLLLQSIGQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
T+YPLL++SI +NT E + ++LA E E+ VN+ VR+ E+ RL+ Q +
Sbjct: 1328 TRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQC 1387
Query: 592 SHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDER 651
L ++ ++ + +KL+H G L ++ +K E+H L +D LLL +
Sbjct: 1388 EGL---AEQLIFNSLTNCLGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQF 1441
Query: 652 LLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQT 711
+ + + + + + + + ++ TD + +F ++Y L
Sbjct: 1442 AVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDN 1501
Query: 712 VSERKNW 718
++ER W
Sbjct: 1502 INERTAW 1508
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 114 bits (286), Expect = 3e-25
Identities = 94/367 (25%), Positives = 172/367 (46%), Gaps = 15/367 (4%)
Query: 355 LELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMA 414
+++ + P + TL ++ + KRQ I EL+ TE ++ L+++ ++F + MA
Sbjct: 1181 VKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1240
Query: 415 ECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEG 472
E F E+ IF + ELI ++ L L R++ G ++ IGD+L A +
Sbjct: 1241 ESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA 1300
Query: 473 SWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRL 532
RFCS Q L+ K +D F F+++ S PRC+ + L + MQR+
Sbjct: 1301 Y------IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRI 1354
Query: 533 TKYPLLLQSIGQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
T+YPLL++SI +NT E + ++LA E E+ VN+ VR+ E+ RL+ Q +
Sbjct: 1355 TRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQC 1414
Query: 592 SHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDER 651
L ++ ++ + +KL+H G L ++ +K E+H L +D LLL +
Sbjct: 1415 EGL---AEQLIFNSLTNCLGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQF 1468
Query: 652 LLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQT 711
+ + + + + + + + ++ TD + +F ++Y L
Sbjct: 1469 AVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDN 1528
Query: 712 VSERKNW 718
++ER W
Sbjct: 1529 INERTAW 1535
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 111 bits (277), Expect = 3e-24
Identities = 95/348 (27%), Positives = 168/348 (48%), Gaps = 16/348 (4%)
Query: 374 LHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDE 433
L L ++ KRQ I EL+VTE +V L+++ ++F +P+ E +E+ IF + E
Sbjct: 1228 LDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKE 1287
Query: 434 LIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALE 491
LI + L L R++ SG ++ IGD+L A+ + RFCSRQ
Sbjct: 1288 LIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPY------IRFCSRQLNGAA 1341
Query: 492 QLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNT-EEPT 550
++ K + P F FV+ PRC+ + L I MQR+T+YPL++++I +NT E
Sbjct: 1342 LIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHP 1401
Query: 551 EREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDI 610
+ ++ A E E+ VN+ VR+ E+ RL+ Q + L S+ ++ +
Sbjct: 1402 DHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---SEQLVFNSVTNCL 1458
Query: 611 TKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTM 670
+K +H G L ++ +K E++ L +D LLL Q + L + +P + +
Sbjct: 1459 GPRKFLHSGKL-YKAKSNK--ELYGFLFNDFLLLTQ-ITKPLGSSGTDKVFSPKSNLQYK 1514
Query: 671 LRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNW 718
+ + + ++ TD +F ++Y L A++++ER W
Sbjct: 1515 MYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAW 1562
>gi|222080070 pleckstrin homology domain-containing family G member
6 isoform b [Homo sapiens]
Length = 758
Score = 103 bits (256), Expect = 9e-22
Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 43/328 (13%)
Query: 348 GEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHD 407
GE G SGL +E WRELVP + + +QE + ELL TE +VR L+++ D
Sbjct: 100 GEGGDSGLTIEKS----WRELVPGHK--EMSQELCHQQEALWELLTTELIYVRKLKIMTD 153
Query: 408 LFFQPMAECLFFPL---EELQNIFPSLDELIEVHSLFLDRLM----KRRQESGYLIEEIG 460
L + L + +F ++ LI H F D ++ + + SG ++ IG
Sbjct: 154 LLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG 213
Query: 461 DVLLARFDGAEGSWFQKISSRF------CSRQSFALEQLKAKQRKDPRFCAFVQEAESRP 514
S F RF C R + + +Q +P F AFVQ E
Sbjct: 214 ----------LQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHK 263
Query: 515 RCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVR 574
R R L D++ QR+TKYPLLL ++ + + E +E + E L H+N VR
Sbjct: 264 RSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVR 323
Query: 575 DMEDLLRLKDYQRRL-DLSHLRQSSDPM---LSEFKNLDITK----------KKLVHEGP 620
E+ L +R+ L SD + L F LD+T ++L+ EGP
Sbjct: 324 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 383
Query: 621 LTWRVTKDKAVEVHVLLLDDLLLLLQRQ 648
+ + ++ ++V++ L D+LL+ + Q
Sbjct: 384 VRVKEGREGKLDVYLFLFSDVLLVTKPQ 411
>gi|222080068 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 103 bits (256), Expect = 9e-22
Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 43/328 (13%)
Query: 348 GEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHD 407
GE G SGL +E WRELVP + + +QE + ELL TE +VR L+++ D
Sbjct: 132 GEGGDSGLTIEKS----WRELVPGHK--EMSQELCHQQEALWELLTTELIYVRKLKIMTD 185
Query: 408 LFFQPMAECLFFPL---EELQNIFPSLDELIEVHSLFLDRLM----KRRQESGYLIEEIG 460
L + L + +F ++ LI H F D ++ + + SG ++ IG
Sbjct: 186 LLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG 245
Query: 461 DVLLARFDGAEGSWFQKISSRF------CSRQSFALEQLKAKQRKDPRFCAFVQEAESRP 514
S F RF C R + + +Q +P F AFVQ E
Sbjct: 246 ----------LQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHK 295
Query: 515 RCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVR 574
R R L D++ QR+TKYPLLL ++ + + E +E + E L H+N VR
Sbjct: 296 RSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVR 355
Query: 575 DMEDLLRLKDYQRRL-DLSHLRQSSDPM---LSEFKNLDITK----------KKLVHEGP 620
E+ L +R+ L SD + L F LD+T ++L+ EGP
Sbjct: 356 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 415
Query: 621 LTWRVTKDKAVEVHVLLLDDLLLLLQRQ 648
+ + ++ ++V++ L D+LL+ + Q
Sbjct: 416 VRVKEGREGKLDVYLFLFSDVLLVTKPQ 443
>gi|222080066 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 103 bits (256), Expect = 9e-22
Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 43/328 (13%)
Query: 348 GEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHD 407
GE G SGL +E WRELVP + + +QE + ELL TE +VR L+++ D
Sbjct: 132 GEGGDSGLTIEKS----WRELVPGHK--EMSQELCHQQEALWELLTTELIYVRKLKIMTD 185
Query: 408 LFFQPMAECLFFPL---EELQNIFPSLDELIEVHSLFLDRLM----KRRQESGYLIEEIG 460
L + L + +F ++ LI H F D ++ + + SG ++ IG
Sbjct: 186 LLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG 245
Query: 461 DVLLARFDGAEGSWFQKISSRF------CSRQSFALEQLKAKQRKDPRFCAFVQEAESRP 514
S F RF C R + + +Q +P F AFVQ E
Sbjct: 246 ----------LQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHK 295
Query: 515 RCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVR 574
R R L D++ QR+TKYPLLL ++ + + E +E + E L H+N VR
Sbjct: 296 RSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVR 355
Query: 575 DMEDLLRLKDYQRRL-DLSHLRQSSDPM---LSEFKNLDITK----------KKLVHEGP 620
E+ L +R+ L SD + L F LD+T ++L+ EGP
Sbjct: 356 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 415
Query: 621 LTWRVTKDKAVEVHVLLLDDLLLLLQRQ 648
+ + ++ ++V++ L D+LL+ + Q
Sbjct: 416 VRVKEGREGKLDVYLFLFSDVLLVTKPQ 443
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
[Homo sapiens]
Length = 596
Score = 84.3 bits (207), Expect = 4e-16
Identities = 91/366 (24%), Positives = 159/366 (43%), Gaps = 41/366 (11%)
Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
W E++ SL +++RQE I E+ E + L++ + PM + EEL
Sbjct: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 215
Query: 425 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 482
+IF LD I +H L R+ + + G +E+IG +L+ SW ++++ +
Sbjct: 216 THIFGDLDSYIPLHEDLLTRIGEATKPDG-TVEQIGHILV--------SWLPRLNAYRGY 266
Query: 483 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 542
CS Q A + L ++++DPR F+Q P R+L L + RL KYPLLL+ I
Sbjct: 267 CSNQ-LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEI 325
Query: 543 GQNTEEPTEREKVELAAEC---CREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSD 599
++T P E V+L + + +L +N + E + Y +L+ +Q D
Sbjct: 326 LKHT--PKEHPDVQLLEDAILIIQGVLSDINLKKGESE----CQYYIDKLEYLDEKQ-RD 378
Query: 600 PMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSR 659
P ++ +K L H + ++++ L D +L+L R R S+
Sbjct: 379 P------RIEASKVLLCH-----GELRSKSGHKLYIFLFQD-ILVLTRPVTRNERHSYQV 426
Query: 660 TLTPTPDGKTMLRPV----LRLTSAMTREVATDHKA---FYVLFTWDQEAQIYELVAQTV 712
P P + +L + +R+ + + KA F + F AQ + L A V
Sbjct: 427 YRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDV 486
Query: 713 SERKNW 718
++ W
Sbjct: 487 FHKQQW 492
>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2
[Homo sapiens]
Length = 542
Score = 84.3 bits (207), Expect = 4e-16
Identities = 91/366 (24%), Positives = 159/366 (43%), Gaps = 41/366 (11%)
Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
W E++ SL +++RQE I E+ E + L++ + PM + EEL
Sbjct: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 161
Query: 425 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 482
+IF LD I +H L R+ + + G +E+IG +L+ SW ++++ +
Sbjct: 162 THIFGDLDSYIPLHEDLLTRIGEATKPDG-TVEQIGHILV--------SWLPRLNAYRGY 212
Query: 483 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 542
CS Q A + L ++++DPR F+Q P R+L L + RL KYPLLL+ I
Sbjct: 213 CSNQ-LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEI 271
Query: 543 GQNTEEPTEREKVELAAEC---CREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSD 599
++T P E V+L + + +L +N + E + Y +L+ +Q D
Sbjct: 272 LKHT--PKEHPDVQLLEDAILIIQGVLSDINLKKGESE----CQYYIDKLEYLDEKQ-RD 324
Query: 600 PMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSR 659
P ++ +K L H + ++++ L D +L+L R R S+
Sbjct: 325 P------RIEASKVLLCH-----GELRSKSGHKLYIFLFQD-ILVLTRPVTRNERHSYQV 372
Query: 660 TLTPTPDGKTMLRPV----LRLTSAMTREVATDHKA---FYVLFTWDQEAQIYELVAQTV 712
P P + +L + +R+ + + KA F + F AQ + L A V
Sbjct: 373 YRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDV 432
Query: 713 SERKNW 718
++ W
Sbjct: 433 FHKQQW 438
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 82.8 bits (203), Expect = 1e-15
Identities = 95/375 (25%), Positives = 172/375 (45%), Gaps = 55/375 (14%)
Query: 357 LEPEEPPG---WRELVPPDTLHSLPKSQV--KRQEVISELLVTEAAHVRMLRVLHDLFFQ 411
+E EE G + +L+ + + PK KR + E+ TE + L + F +
Sbjct: 163 VENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLK 222
Query: 412 PMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL-IEEIGDVLLARFDGA 470
P+ F ++++ IF ++++L+ VH+ FL + + G + ++ RF
Sbjct: 223 PLQR--FLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERF--- 277
Query: 471 EGSWFQKISSRFCSRQSFALEQLK--AKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTE 528
+ R+CS+ A + L A R+D + ++E R R L+D++
Sbjct: 278 ------LVYGRYCSQVESASKHLDRVAAAREDVQMK--LEECSQRANNGRFTLRDLLMVP 329
Query: 529 MQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRR 588
MQR+ KY LLLQ + ++T+E E+E + LA + R++ VN+ RD E L ++ ++Q
Sbjct: 330 MQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQ-- 387
Query: 589 LDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQ 648
L + +L QS L+ + + K+ E +T V + ++ + LLD LL+ +R+
Sbjct: 388 LSIENLDQS----LAHY-----GRPKIDGELKIT-SVERRSKMDRYAFLLDKALLICKRR 437
Query: 649 DERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT---DHKAFYVLFTW--DQEAQ 703
+ LK + L S R+ ++ D+K + +F DQ AQ
Sbjct: 438 GDSYDLKD-----------------FVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ 480
Query: 704 IYELVAQTVSERKNW 718
YEL +T +K W
Sbjct: 481 GYELFFKTRELKKKW 495
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
[Homo sapiens]
Length = 532
Score = 82.4 bits (202), Expect = 2e-15
Identities = 89/372 (23%), Positives = 157/372 (42%), Gaps = 41/372 (11%)
Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
W E L ++KRQE I EL E + L++ + PM + +EL
Sbjct: 110 WSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQEL 169
Query: 425 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 482
IF +LD LI +H L +L R+ G E +G +L+ W +SS +
Sbjct: 170 NQIFGTLDSLIPLHEELLSQLRDVRKPDG-STEHVGPILV--------GWLPCLSSYDSY 220
Query: 483 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 542
CS Q A + L +++D R F+Q P R+L L + + RL KYPLLL+ I
Sbjct: 221 CSNQ-VAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREI 279
Query: 543 GQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPM 601
++T + +++ +E A + I+ +N + E + Y+ R L +L +
Sbjct: 280 LRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESE----CRYYKER--LLYLEEGQKDS 333
Query: 602 LSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQ--RQDERLLLKSHSR 659
L +D ++ H + ++ V++HV L ++L++ + +E+L + + +
Sbjct: 334 L-----IDSSRVLCCH-----GELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQ 383
Query: 660 -------TLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTV 712
L DG+ L LR + + F V F ++Q + L A
Sbjct: 384 PIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERI---KNFFRVSFKNGSQSQTHSLQANDT 440
Query: 713 SERKNWCALITE 724
++ W I +
Sbjct: 441 FNKQQWLNCIRQ 452
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,574,187
Number of Sequences: 37866
Number of extensions: 2102280
Number of successful extensions: 16090
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 108
Number of HSP's successfully gapped in prelim test: 445
Number of HSP's that attempted gapping in prelim test: 12577
Number of HSP's gapped (non-prelim): 2687
length of query: 879
length of database: 18,247,518
effective HSP length: 111
effective length of query: 768
effective length of database: 14,044,392
effective search space: 10786093056
effective search space used: 10786093056
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.