Guide to the Human Genome
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Search of human proteins with 39777604

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
         (879 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [...  1751   0.0  
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [...  1734   0.0  
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [...  1734   0.0  
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo...   483   e-136
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof...   413   e-115
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo...   413   e-115
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]       189   1e-47
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]       189   1e-47
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]       189   1e-47
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo...   181   3e-45
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor...   177   3e-44
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor...   168   2e-41
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor...   168   2e-41
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor...   168   2e-41
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]    150   4e-36
gi|38373682 pleckstrin homology domain containing family G membe...   136   7e-32
gi|111154084 pleckstrin homology domain containing family G memb...   136   7e-32
gi|111154088 pleckstrin homology domain containing family G memb...   136   7e-32
gi|111154080 pleckstrin homology domain containing family G memb...   136   7e-32
gi|111154078 pleckstrin homology domain containing family G memb...   136   7e-32
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                   114   3e-25
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                   114   3e-25
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]               111   3e-24
gi|222080070 pleckstrin homology domain-containing family G memb...   103   9e-22
gi|222080068 pleckstrin homology domain-containing family G memb...   103   9e-22
gi|222080066 pleckstrin homology domain-containing family G memb...   103   9e-22
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ...    84   4e-16
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [...    84   4e-16
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]     83   1e-15
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ...    82   2e-15

>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
           [Homo sapiens]
          Length = 879

 Score = 1751 bits (4535), Expect = 0.0
 Identities = 879/879 (100%), Positives = 879/879 (100%)

Query: 1   MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM 60
           MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM
Sbjct: 1   MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM 60

Query: 61  ALLQHVALQFEPGPLVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQ 120
           ALLQHVALQFEPGPLVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQ
Sbjct: 61  ALLQHVALQFEPGPLVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQ 120

Query: 121 LEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEE 180
           LEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEE
Sbjct: 121 LEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEE 180

Query: 181 KSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAAR 240
           KSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAAR
Sbjct: 181 KSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAAR 240

Query: 241 WNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDS 300
           WNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDS
Sbjct: 241 WNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDS 300

Query: 301 PDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPE 360
           PDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPE
Sbjct: 301 PDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPE 360

Query: 361 EPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFP 420
           EPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFP
Sbjct: 361 EPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFP 420

Query: 421 LEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS 480
           LEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS
Sbjct: 421 LEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS 480

Query: 481 RFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQ 540
           RFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQ
Sbjct: 481 RFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQ 540

Query: 541 SIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDP 600
           SIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDP
Sbjct: 541 SIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDP 600

Query: 601 MLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRT 660
           MLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRT
Sbjct: 601 MLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRT 660

Query: 661 LTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCA 720
           LTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCA
Sbjct: 661 LTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCA 720

Query: 721 LITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLP 780
           LITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLP
Sbjct: 721 LITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLP 780

Query: 781 FCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQEN 840
           FCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQEN
Sbjct: 781 FCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQEN 840

Query: 841 LLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT 879
           LLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT
Sbjct: 841 LLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT 879


>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
           [Homo sapiens]
          Length = 927

 Score = 1734 bits (4491), Expect = 0.0
 Identities = 879/912 (96%), Positives = 879/912 (96%), Gaps = 33/912 (3%)

Query: 1   MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM 60
           MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM
Sbjct: 16  MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM 75

Query: 61  ALLQHVALQFEPGPL---------------------------------VLRVPVPPNVAF 87
           ALLQHVALQFEPGPL                                 VLRVPVPPNVAF
Sbjct: 76  ALLQHVALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAF 135

Query: 88  ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG 147
           ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG
Sbjct: 136 ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG 195

Query: 148 RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKS 207
           RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKS
Sbjct: 196 RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKS 255

Query: 208 GRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATD 267
           GRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATD
Sbjct: 256 GRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATD 315

Query: 268 RKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL 327
           RKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL
Sbjct: 316 RKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL 375

Query: 328 APPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEV 387
           APPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEV
Sbjct: 376 APPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEV 435

Query: 388 ISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMK 447
           ISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMK
Sbjct: 436 ISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMK 495

Query: 448 RRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV 507
           RRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV
Sbjct: 496 RRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV 555

Query: 508 QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILH 567
           QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILH
Sbjct: 556 QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILH 615

Query: 568 HVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTK 627
           HVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTK
Sbjct: 616 HVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTK 675

Query: 628 DKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT 687
           DKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT
Sbjct: 676 DKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT 735

Query: 688 DHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSST 747
           DHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSST
Sbjct: 736 DHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSST 795

Query: 748 REPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFP 807
           REPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFP
Sbjct: 796 REPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFP 855

Query: 808 AEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQ 867
           AEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQ
Sbjct: 856 AEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQ 915

Query: 868 LGGNSVPQPGCT 879
           LGGNSVPQPGCT
Sbjct: 916 LGGNSVPQPGCT 927


>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
           [Homo sapiens]
          Length = 912

 Score = 1734 bits (4491), Expect = 0.0
 Identities = 879/912 (96%), Positives = 879/912 (96%), Gaps = 33/912 (3%)

Query: 1   MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM 60
           MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM
Sbjct: 1   MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM 60

Query: 61  ALLQHVALQFEPGPL---------------------------------VLRVPVPPNVAF 87
           ALLQHVALQFEPGPL                                 VLRVPVPPNVAF
Sbjct: 61  ALLQHVALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAF 120

Query: 88  ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG 147
           ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG
Sbjct: 121 ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG 180

Query: 148 RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKS 207
           RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKS
Sbjct: 181 RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKS 240

Query: 208 GRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATD 267
           GRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATD
Sbjct: 241 GRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATD 300

Query: 268 RKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL 327
           RKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL
Sbjct: 301 RKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESL 360

Query: 328 APPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEV 387
           APPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEV
Sbjct: 361 APPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEV 420

Query: 388 ISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMK 447
           ISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMK
Sbjct: 421 ISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMK 480

Query: 448 RRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV 507
           RRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV
Sbjct: 481 RRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV 540

Query: 508 QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILH 567
           QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILH
Sbjct: 541 QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILH 600

Query: 568 HVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTK 627
           HVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTK
Sbjct: 601 HVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTK 660

Query: 628 DKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT 687
           DKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT
Sbjct: 661 DKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT 720

Query: 688 DHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSST 747
           DHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSST
Sbjct: 721 DHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSST 780

Query: 748 REPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFP 807
           REPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFP
Sbjct: 781 REPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFP 840

Query: 808 AEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQ 867
           AEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQ
Sbjct: 841 AEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQ 900

Query: 868 LGGNSVPQPGCT 879
           LGGNSVPQPGCT
Sbjct: 901 LGGNSVPQPGCT 912


>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
            sapiens]
          Length = 1544

 Score =  483 bits (1242), Expect = e-136
 Identities = 312/811 (38%), Positives = 460/811 (56%), Gaps = 100/811 (12%)

Query: 23   IIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLV------ 76
            IIGAED+DF  E E     Q S FQS+E +K RPAHL   L HV  QF+P  L+      
Sbjct: 350  IIGAEDDDFGTEHE-QINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSD 408

Query: 77   ---------------------------LRVPVPPNVAFELDRTRADLISEDVQRRFVQEV 109
                                       L+V VP  ++ +L++ R +LI ED+ R ++Q +
Sbjct: 409  LYKHTNSKETRRIFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTM 468

Query: 110  VQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLE 169
             +     V R LEDFR KR MG+T  E EL +L+A   +DR + E +ER  AE+++  +E
Sbjct: 469  QERVHPEVQRHLEDFRQKRSMGLTLAESELTKLDAERDKDRLTLE-KERTCAEQIVAKIE 527

Query: 170  EMQHTI-STDEEKSAAVVNAIGLYMRHLGVRTKSG---DKKSGRNFFRKKVMGNRRSDEP 225
            E+  T  + +E+KS+ +   I +YM+HLGV+ K     + K GR  F  K+  + + D+ 
Sbjct: 528  EVLMTAQAVEEDKSSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDKE 587

Query: 226  AKTK---KGLSSILDAARWNRGEPQVPDFRHLKAEVD-------AEKPGATDRKGGVGMP 275
             + K   +G  SIL       G P+ P  RH  + +        A  P        V   
Sbjct: 588  GEEKGKRRGFPSIL-------GPPRRPS-RHDNSAIGRAMELQKARHPKHLSTPSSVSPE 639

Query: 276  SRD----RNIGAPGQDTPGVSLHPLSLDSP------DREPGAD---APLELGDSSPQG-- 320
             +D    R  G   + T    L   S+ S        +E G +      ++G++S  G  
Sbjct: 640  PQDSAKLRQSGLANEGTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDT 699

Query: 321  ----PMSLESLA--PPESTDEGAETE----------SPEPGDE------GEPGRSGLELE 358
                P +L ++   PP   D+  E E          +P+P  +      GE      + E
Sbjct: 700  LDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFE 759

Query: 359  PE---EPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAE 415
             +   +PP W++LV  + L  L   ++KRQEVI+EL  TE AHVR L+VL  +F+Q ++ 
Sbjct: 760  NDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSR 819

Query: 416  CLFFPLEELQNIFPSLDELIEVHSLFLDRLMK--RRQESGYLIEEIGDVLLARFDGAEGS 473
                   EL+ IF +L++++++H + L+  MK  R++    +I++IG+ LL  F G    
Sbjct: 820  EGILSPSELRKIFSNLEDILQLH-IGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEE 878

Query: 474  WFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLT 533
              +  ++ FCS Q FALE +K++Q+KD RF  FVQ+AES P CRRLQLKD+IPT+MQRLT
Sbjct: 879  KLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLT 938

Query: 534  KYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSH 593
            KYPLLL +I + TE PTEREKV+ AA+ CR+IL++VNQAV++ E+  RL+DYQRRLD S 
Sbjct: 939  KYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSS 998

Query: 594  LRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLL 653
            L+ S  P + E +NLD+TK+K++HEGPL W+V +DK ++++ LLL+D+L+LLQ+QD+RL+
Sbjct: 999  LKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLV 1058

Query: 654  LKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVS 713
            L+ HS+ L  T D K    PV++L++ + R+VATD+KA +V+   D  AQIYELVAQTVS
Sbjct: 1059 LRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVS 1118

Query: 714  ERKNWCALITETAGSLKVPAPASRPKPRPSP 744
            E+  W  LI   A S+K  +    P P+ +P
Sbjct: 1119 EKTVWQDLICRMAASVKEQSTKPIPLPQSTP 1149


>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
            [Homo sapiens]
          Length = 1562

 Score =  413 bits (1062), Expect = e-115
 Identities = 321/914 (35%), Positives = 470/914 (51%), Gaps = 138/914 (15%)

Query: 8    AASPGPSRPGL--VPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQH 65
            AA P     G+   P  +I   +ED++     N  E +  FQ LE++K RPAHL   L++
Sbjct: 313  AAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNN--ESDIIFQDLEKLKSRPAHLGVFLRY 370

Query: 66   VALQFEPGPLV---------------------------------LRVPVPPNVAFELDRT 92
            +  Q +P PL+                                 LRV +P  +  E+D  
Sbjct: 371  IFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSR 430

Query: 93   RADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPW--EQELAQLEAWVGRDR 150
              +  SED  R  + E  ++    +  Q+ D+R+KR +G+     E +L  L+       
Sbjct: 431  LRN--SEDA-RGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDG------ 481

Query: 151  ASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSG------- 203
                 RER VAE+ L  L ++      +E++SA +  A+  YM H G+R +         
Sbjct: 482  --DPLRERQVAEKQLAALGDILSKY--EEDRSAPMDFALNTYMSHAGIRLREARPSNTAE 537

Query: 204  ------DKKSGRNFFRK-KVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQ----VP--- 249
                  DK     FF K K   N + ++ A   K  + IL      +   Q    +P   
Sbjct: 538  KAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSP 597

Query: 250  ------DFRHL------KAEVDAEKPGATDRKGGVGMP--------SRD-----RNIGAP 284
                  + R++        + DA +PG T R      P        SR      R+    
Sbjct: 598  VEVKPGNVRNIIQHFENNQQYDAPEPG-TQRLSTGSFPEDLLESDSSRSEIRLGRSESLK 656

Query: 285  GQDTPGVSLH----PLSLDSPDREPGADAP-LELGDSSPQGPMSLESL---APPESTDEG 336
            G++    S      P S    D +  A+A  L    SS    +S  SL    PP +   G
Sbjct: 657  GREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMG 716

Query: 337  AET-ESPEPGD----------EGEPGRSGLELEPE-EPPGWRELVPPDTLHSLPKSQVKR 384
              + ESP  G           E + G+   +LEPE +   W+  V  D +  L + ++ R
Sbjct: 717  RRSIESPSLGFCTDTLLPHLLEDDLGQLS-DLEPEPDAQNWQHTVGKDVVAGLTQREIDR 775

Query: 385  QEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDR 444
            QEVI+EL VTEA+H+R LRVL  +F+Q M +    P EEL  +FP+L ELIE+H+ + + 
Sbjct: 776  QEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA 835

Query: 445  LMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFC 504
            + K R+E G +I+EI D++LARFDG      Q+++++FCS QS ALE +K KQRK+ RF 
Sbjct: 836  MKKLREE-GPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQ 894

Query: 505  AFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPT-EREKVELAAECCR 563
             F+QEAES P+CRRLQL+D+I +EMQRLTKYPLLL+SI ++TE  T E EK+  A + CR
Sbjct: 895  LFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCR 954

Query: 564  EILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623
            EIL +VN+AV+  E+  RL+ YQ+RLD + L ++S+P+ +EFK+LD+T +K++HEGPLTW
Sbjct: 955  EILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTW 1014

Query: 624  RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683
            R++KDK +++HVLLL+DLL+LLQ+QDE+LLLK HS+T   + D K    PVL+L + + R
Sbjct: 1015 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1074

Query: 684  EVATDHKAFYVLFTWD-QEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKP-R 741
             VATD +AF+++ T      QIYELVA T S++  W  L+ E   +     P + P P  
Sbjct: 1075 SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN-ATRHPGAAPMPVH 1133

Query: 742  PSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAAT-ALRKVLS 800
            P P   REP            +  P  +R E   SD+     P PE     T + ++V  
Sbjct: 1134 PPPPGPREP-----------AQQGPTPSRVELDDSDVF-HGEPEPEELPGGTGSQQRVQG 1181

Query: 801  LKQLLFPAEEDNGA 814
              Q+L    E  G+
Sbjct: 1182 KHQVLLEDPEQEGS 1195


>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
            [Homo sapiens]
          Length = 1522

 Score =  413 bits (1062), Expect = e-115
 Identities = 321/914 (35%), Positives = 470/914 (51%), Gaps = 138/914 (15%)

Query: 8    AASPGPSRPGL--VPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQH 65
            AA P     G+   P  +I   +ED++     N  E +  FQ LE++K RPAHL   L++
Sbjct: 273  AAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNN--ESDIIFQDLEKLKSRPAHLGVFLRY 330

Query: 66   VALQFEPGPLV---------------------------------LRVPVPPNVAFELDRT 92
            +  Q +P PL+                                 LRV +P  +  E+D  
Sbjct: 331  IFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSR 390

Query: 93   RADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPW--EQELAQLEAWVGRDR 150
              +  SED  R  + E  ++    +  Q+ D+R+KR +G+     E +L  L+       
Sbjct: 391  LRN--SEDA-RGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDG------ 441

Query: 151  ASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSG------- 203
                 RER VAE+ L  L ++      +E++SA +  A+  YM H G+R +         
Sbjct: 442  --DPLRERQVAEKQLAALGDILSKY--EEDRSAPMDFALNTYMSHAGIRLREARPSNTAE 497

Query: 204  ------DKKSGRNFFRK-KVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQ----VP--- 249
                  DK     FF K K   N + ++ A   K  + IL      +   Q    +P   
Sbjct: 498  KAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSP 557

Query: 250  ------DFRHL------KAEVDAEKPGATDRKGGVGMP--------SRD-----RNIGAP 284
                  + R++        + DA +PG T R      P        SR      R+    
Sbjct: 558  VEVKPGNVRNIIQHFENNQQYDAPEPG-TQRLSTGSFPEDLLESDSSRSEIRLGRSESLK 616

Query: 285  GQDTPGVSLH----PLSLDSPDREPGADAP-LELGDSSPQGPMSLESL---APPESTDEG 336
            G++    S      P S    D +  A+A  L    SS    +S  SL    PP +   G
Sbjct: 617  GREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMG 676

Query: 337  AET-ESPEPGD----------EGEPGRSGLELEPE-EPPGWRELVPPDTLHSLPKSQVKR 384
              + ESP  G           E + G+   +LEPE +   W+  V  D +  L + ++ R
Sbjct: 677  RRSIESPSLGFCTDTLLPHLLEDDLGQLS-DLEPEPDAQNWQHTVGKDVVAGLTQREIDR 735

Query: 385  QEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDR 444
            QEVI+EL VTEA+H+R LRVL  +F+Q M +    P EEL  +FP+L ELIE+H+ + + 
Sbjct: 736  QEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA 795

Query: 445  LMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFC 504
            + K R+E G +I+EI D++LARFDG      Q+++++FCS QS ALE +K KQRK+ RF 
Sbjct: 796  MKKLREE-GPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQ 854

Query: 505  AFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPT-EREKVELAAECCR 563
             F+QEAES P+CRRLQL+D+I +EMQRLTKYPLLL+SI ++TE  T E EK+  A + CR
Sbjct: 855  LFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCR 914

Query: 564  EILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623
            EIL +VN+AV+  E+  RL+ YQ+RLD + L ++S+P+ +EFK+LD+T +K++HEGPLTW
Sbjct: 915  EILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTW 974

Query: 624  RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683
            R++KDK +++HVLLL+DLL+LLQ+QDE+LLLK HS+T   + D K    PVL+L + + R
Sbjct: 975  RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1034

Query: 684  EVATDHKAFYVLFTWD-QEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKP-R 741
             VATD +AF+++ T      QIYELVA T S++  W  L+ E   +     P + P P  
Sbjct: 1035 SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN-ATRHPGAAPMPVH 1093

Query: 742  PSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAAT-ALRKVLS 800
            P P   REP            +  P  +R E   SD+     P PE     T + ++V  
Sbjct: 1094 PPPPGPREP-----------AQQGPTPSRVELDDSDVF-HGEPEPEELPGGTGSQQRVQG 1141

Query: 801  LKQLLFPAEEDNGA 814
              Q+L    E  G+
Sbjct: 1142 KHQVLLEDPEQEGS 1155


>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
          Length = 2817

 Score =  189 bits (480), Expect = 1e-47
 Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)

Query: 333  TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 392
            TDEG  T+  E    G+      +LE E    W  ++    L    K  VKRQEVI EL+
Sbjct: 1951 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 2007

Query: 393  VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 452
             TE  HVR L+++  ++ Q M   L F  + ++ +FP LDELI +HS F  R+++R++ES
Sbjct: 2008 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 2067

Query: 453  -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 505
                    +LI+ IGDVL+ +F G      +K   +FC + + ++   K    KD RF A
Sbjct: 2068 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 2127

Query: 506  FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 564
            FV++  S    RRL + + I    QR+TKYP+L Q I Q T++   E+E +  +    ++
Sbjct: 2128 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 2187

Query: 565  ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623
            ++  V+  V   E  +RL +   + D  S +R  S  M   F   D+ +KKLV +G +  
Sbjct: 2188 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 2244

Query: 624  RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683
            +    +  EV  +LL D+L+ LQ +D++ +  S  +  T           V+ L   + R
Sbjct: 2245 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 2293

Query: 684  EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 729
            EVA + K  +++     + ++ E+ A +  ER +W  +I +T  +L
Sbjct: 2294 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2339


>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
          Length = 1058

 Score =  189 bits (480), Expect = 1e-47
 Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)

Query: 333 TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 392
           TDEG  T+  E    G+      +LE E    W  ++    L    K  VKRQEVI EL+
Sbjct: 192 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 248

Query: 393 VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 452
            TE  HVR L+++  ++ Q M   L F  + ++ +FP LDELI +HS F  R+++R++ES
Sbjct: 249 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 308

Query: 453 -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 505
                   +LI+ IGDVL+ +F G      +K   +FC + + ++   K    KD RF A
Sbjct: 309 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 368

Query: 506 FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 564
           FV++  S    RRL + + I    QR+TKYP+L Q I Q T++   E+E +  +    ++
Sbjct: 369 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 428

Query: 565 ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623
           ++  V+  V   E  +RL +   + D  S +R  S  M   F   D+ +KKLV +G +  
Sbjct: 429 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 485

Query: 624 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683
           +    +  EV  +LL D+L+ LQ +D++ +  S  +  T           V+ L   + R
Sbjct: 486 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 534

Query: 684 EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 729
           EVA + K  +++     + ++ E+ A +  ER +W  +I +T  +L
Sbjct: 535 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 580


>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
          Length = 2813

 Score =  189 bits (480), Expect = 1e-47
 Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)

Query: 333  TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 392
            TDEG  T+  E    G+      +LE E    W  ++    L    K  VKRQEVI EL+
Sbjct: 1947 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 2003

Query: 393  VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 452
             TE  HVR L+++  ++ Q M   L F  + ++ +FP LDELI +HS F  R+++R++ES
Sbjct: 2004 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 2063

Query: 453  -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 505
                    +LI+ IGDVL+ +F G      +K   +FC + + ++   K    KD RF A
Sbjct: 2064 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 2123

Query: 506  FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 564
            FV++  S    RRL + + I    QR+TKYP+L Q I Q T++   E+E +  +    ++
Sbjct: 2124 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 2183

Query: 565  ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623
            ++  V+  V   E  +RL +   + D  S +R  S  M   F   D+ +KKLV +G +  
Sbjct: 2184 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 2240

Query: 624  RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683
            +    +  EV  +LL D+L+ LQ +D++ +  S  +  T           V+ L   + R
Sbjct: 2241 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 2289

Query: 684  EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 729
            EVA + K  +++     + ++ E+ A +  ER +W  +I +T  +L
Sbjct: 2290 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2335


>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform
           b [Homo sapiens]
          Length = 1173

 Score =  181 bits (458), Expect = 3e-45
 Identities = 168/608 (27%), Positives = 270/608 (44%), Gaps = 76/608 (12%)

Query: 273 GMPSRDRNIG-----------APGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGP 321
           G P+  RN+G            P    PG  L P++ +  + +       +  D S    
Sbjct: 149 GSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSL--- 205

Query: 322 MSLESLAPPESTDEGAETESPEPGD-EGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKS 380
               SL  P +  E    E P       E    G E E E    W   V         + 
Sbjct: 206 ----SLTSPNT--ESIFVEDPYTASLRSEIESDGHEFEAES---WSLAVDAAYAKKQKRE 256

Query: 381 QVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSL 440
            VKRQ+V+ EL+ TE  HVR L+++  ++ + + E L F  + +  +FP  D+L+E HS 
Sbjct: 257 VVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSH 316

Query: 441 FLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQL 493
           FL RL +RRQES        Y+I++IGD+L+ +F G  G   ++    FCS  + A+   
Sbjct: 317 FLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHY 376

Query: 494 KAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTE-R 552
           K   +++ +F   +++  +    RRL +++ I    QR+TKYP+L++ I QNTE  TE  
Sbjct: 377 KLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDY 436

Query: 553 EKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITK 612
           E +  A    ++I+  V+  V + E   RL++   ++DL    +  + +   F+  D+ +
Sbjct: 437 EDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGL--TFRKEDMLQ 494

Query: 613 KKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLR 672
           ++L  EG L W+ T  +  ++  +LL D+LLLLQ +D++ +  S         D K    
Sbjct: 495 RQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFAS--------VDSKP--- 543

Query: 673 PVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVP 732
           PV+ L   + REVA + KA +++    Q  ++YE+   +  +R  W A I          
Sbjct: 544 PVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQR-------- 595

Query: 733 APASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAA 792
           A  S P     P S  E             E    +AR  R L D     R   + QL A
Sbjct: 596 AVESCPDEEEGPFSLPE------------EERKVVEARATR-LRDFQE--RLSMKDQLIA 640

Query: 793 TALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLE 852
            +L   L  +Q+     E  G        G+  GG  S     E  +  L L+  M ++E
Sbjct: 641 QSL---LEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPS-----ETLQGELILKSAMSEIE 692

Query: 853 ELEEEFCR 860
            ++   CR
Sbjct: 693 GIQSLICR 700


>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
           [Homo sapiens]
          Length = 1015

 Score =  177 bits (450), Expect = 3e-44
 Identities = 155/545 (28%), Positives = 250/545 (45%), Gaps = 56/545 (10%)

Query: 325 ESLAPPESTDEGAETESPEPGD-EGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVK 383
           +SL+      E    E P       E    G E E E    W   V         +  VK
Sbjct: 45  DSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAES---WSLAVDAAYAKKQKREVVK 101

Query: 384 RQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLD 443
           RQ+V+ EL+ TE  HVR L+++  ++ + + E L F  + +  +FP  D+L+E HS FL 
Sbjct: 102 RQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLA 161

Query: 444 RLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAK 496
           RL +RRQES        Y+I++IGD+L+ +F G  G   ++    FCS  + A+   K  
Sbjct: 162 RLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLL 221

Query: 497 QRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTE-REKV 555
            +++ +F   +++  +    RRL +++ I    QR+TKYP+L++ I QNTE  TE  E +
Sbjct: 222 LQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDL 281

Query: 556 ELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKL 615
             A    ++I+  V+  V + E   RL++   ++DL    +  + +   F+  D+ +++L
Sbjct: 282 TQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGL--TFRKEDMLQRQL 339

Query: 616 VHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVL 675
             EG L W+ T  +  ++  +LL D+LLLLQ +D++ +  S         D K    PV+
Sbjct: 340 HLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFAS--------VDSKP---PVI 388

Query: 676 RLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPA 735
            L   + REVA + KA +++    Q  ++YE+   +  +R  W A I          A  
Sbjct: 389 SLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQR--------AVE 440

Query: 736 SRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATAL 795
           S P     P S  E             E    +AR  R L D     R   + QL A +L
Sbjct: 441 SCPDEEEGPFSLPE------------EERKVVEARATR-LRDFQE--RLSMKDQLIAQSL 485

Query: 796 RKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELE 855
              L  +Q+     E  G        G+  GG  S     E  +  L L+  M ++E ++
Sbjct: 486 ---LEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPS-----ETLQGELILKSAMSEIEGIQ 537

Query: 856 EEFCR 860
              CR
Sbjct: 538 SLICR 542


>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
           [Homo sapiens]
          Length = 985

 Score =  168 bits (425), Expect = 2e-41
 Identities = 142/528 (26%), Positives = 245/528 (46%), Gaps = 65/528 (12%)

Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
           W   V    L    K  +K+Q+VI EL+ TE  HVR L+++  LF   M E L      +
Sbjct: 216 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 275

Query: 425 QNIFPSLDELIEVHSLFLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQK 477
           Q +FP +DEL ++H+ FL +L++RR+++        ++I  +GD+L+++F G       K
Sbjct: 276 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 335

Query: 478 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 537
             S FCSR S AL+  K    +D RF  F+++       +R  +++ I    QR+TKYPL
Sbjct: 336 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 395

Query: 538 LLQSIGQNTEE-PTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQ 596
           L+  I Q++     ER+ +  A    +E+L +V++ +  +E   RL++   R+D     Q
Sbjct: 396 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD--PRAQ 453

Query: 597 SSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKS 656
           +  P    F   ++ ++KL+H+G L W+    +  +V VLL+ D+L+ LQ +D++ +   
Sbjct: 454 TPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIF-- 511

Query: 657 HSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERK 716
                 PT D  +    V+ L + + R++A   K  +++     E  +YE+   +  +R 
Sbjct: 512 ------PTLDKPS----VVSLQNLIVRDIANQEKGMFLISAAPPE--MYEVHTASRDDRS 559

Query: 717 NWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILS 776
            W  +I ++               R  PS    PL+ + +           +A   RI  
Sbjct: 560 TWIRVIQQSV--------------RTCPSREDFPLIETED-----------EAYLRRIKM 594

Query: 777 DLLPFCRPGPEGQLAATALRKVLSL--KQLLFPAEEDNGAGP--PRDGDGVPGGGPLSPA 832
           +L        + +     LR+ + L  +   F AEED G+G   P    G+     L   
Sbjct: 595 EL------QQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESP 648

Query: 833 RTQEIQENLLSLEETMKQL------EELEEEFCRLRPLLSQLGGNSVP 874
           R + + ++ +   E +K L      E L        PL    GGN+ P
Sbjct: 649 RGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSP 696


>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
           [Homo sapiens]
          Length = 986

 Score =  168 bits (425), Expect = 2e-41
 Identities = 142/528 (26%), Positives = 245/528 (46%), Gaps = 65/528 (12%)

Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
           W   V    L    K  +K+Q+VI EL+ TE  HVR L+++  LF   M E L      +
Sbjct: 217 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 276

Query: 425 QNIFPSLDELIEVHSLFLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQK 477
           Q +FP +DEL ++H+ FL +L++RR+++        ++I  +GD+L+++F G       K
Sbjct: 277 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 336

Query: 478 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 537
             S FCSR S AL+  K    +D RF  F+++       +R  +++ I    QR+TKYPL
Sbjct: 337 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 396

Query: 538 LLQSIGQNTEE-PTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQ 596
           L+  I Q++     ER+ +  A    +E+L +V++ +  +E   RL++   R+D     Q
Sbjct: 397 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD--PRAQ 454

Query: 597 SSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKS 656
           +  P    F   ++ ++KL+H+G L W+    +  +V VLL+ D+L+ LQ +D++ +   
Sbjct: 455 TPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIF-- 512

Query: 657 HSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERK 716
                 PT D  +    V+ L + + R++A   K  +++     E  +YE+   +  +R 
Sbjct: 513 ------PTLDKPS----VVSLQNLIVRDIANQEKGMFLISAAPPE--MYEVHTASRDDRS 560

Query: 717 NWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILS 776
            W  +I ++               R  PS    PL+ + +           +A   RI  
Sbjct: 561 TWIRVIQQSV--------------RTCPSREDFPLIETED-----------EAYLRRIKM 595

Query: 777 DLLPFCRPGPEGQLAATALRKVLSL--KQLLFPAEEDNGAGP--PRDGDGVPGGGPLSPA 832
           +L        + +     LR+ + L  +   F AEED G+G   P    G+     L   
Sbjct: 596 EL------QQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESP 649

Query: 833 RTQEIQENLLSLEETMKQL------EELEEEFCRLRPLLSQLGGNSVP 874
           R + + ++ +   E +K L      E L        PL    GGN+ P
Sbjct: 650 RGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSP 697


>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
           [Homo sapiens]
          Length = 958

 Score =  168 bits (425), Expect = 2e-41
 Identities = 142/528 (26%), Positives = 245/528 (46%), Gaps = 65/528 (12%)

Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
           W   V    L    K  +K+Q+VI EL+ TE  HVR L+++  LF   M E L      +
Sbjct: 189 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 248

Query: 425 QNIFPSLDELIEVHSLFLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQK 477
           Q +FP +DEL ++H+ FL +L++RR+++        ++I  +GD+L+++F G       K
Sbjct: 249 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 308

Query: 478 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 537
             S FCSR S AL+  K    +D RF  F+++       +R  +++ I    QR+TKYPL
Sbjct: 309 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 368

Query: 538 LLQSIGQNTEE-PTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQ 596
           L+  I Q++     ER+ +  A    +E+L +V++ +  +E   RL++   R+D     Q
Sbjct: 369 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD--PRAQ 426

Query: 597 SSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKS 656
           +  P    F   ++ ++KL+H+G L W+    +  +V VLL+ D+L+ LQ +D++ +   
Sbjct: 427 TPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIF-- 484

Query: 657 HSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERK 716
                 PT D  +    V+ L + + R++A   K  +++     E  +YE+   +  +R 
Sbjct: 485 ------PTLDKPS----VVSLQNLIVRDIANQEKGMFLISAAPPE--MYEVHTASRDDRS 532

Query: 717 NWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILS 776
            W  +I ++               R  PS    PL+ + +           +A   RI  
Sbjct: 533 TWIRVIQQSV--------------RTCPSREDFPLIETED-----------EAYLRRIKM 567

Query: 777 DLLPFCRPGPEGQLAATALRKVLSL--KQLLFPAEEDNGAGP--PRDGDGVPGGGPLSPA 832
           +L        + +     LR+ + L  +   F AEED G+G   P    G+     L   
Sbjct: 568 EL------QQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESP 621

Query: 833 RTQEIQENLLSLEETMKQL------EELEEEFCRLRPLLSQLGGNSVP 874
           R + + ++ +   E +K L      E L        PL    GGN+ P
Sbjct: 622 RGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSP 669


>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
          Length = 1651

 Score =  150 bits (380), Expect = 4e-36
 Identities = 130/522 (24%), Positives = 231/522 (44%), Gaps = 47/522 (9%)

Query: 225  PAKTKKGLSSILDAARWNRGEPQV----PDFRHLKAEVDAEKPGATDRKGG---VGMPSR 277
            PA TKK         ++N+ +PQ       FR      D  +PG +        VG+P+ 
Sbjct: 697  PACTKKFQE------KYNKNKPQTILGNSSFR------DIPQPGLSLHPSSSVPVGLPTG 744

Query: 278  DRN----IGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPEST 333
             R     +    +  PG +L      +   E  +D       S       L+S+    ST
Sbjct: 745  RRETVGQVHPLSRSVPGTTLESFRRSATSLESESDH--NSCRSRSHSDELLQSMGSSPST 802

Query: 334  DEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLV 393
            +     +  +     +      E E E    W  +V P   +   K  +KRQ+VI EL+ 
Sbjct: 803  ESFIMEDVVDSSLWSDLSSDAQEFEAES---WSLVVDPSFCNRQEKDVIKRQDVIFELMQ 859

Query: 394  TEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES- 452
            TE  H++ L ++ ++F + M E L      +  IFP LDEL+E+H  F   + +RRQES 
Sbjct: 860  TEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESC 919

Query: 453  -----GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV 507
                  ++I+ IGD+L+ +F     S  +KI   FC     A+   K  Q ++ +F  F+
Sbjct: 920  AGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQ-QNKKFQNFI 978

Query: 508  QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAEC-CREIL 566
            +   S    RR  + + I    QR+TKYP+L++ I Q T+E TE  K    A C  ++++
Sbjct: 979  KLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMI 1038

Query: 567  HHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVT 626
              V+  V + E   +  +   +++     +  +  +   + L   ++ L+++G + W+  
Sbjct: 1039 ATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTA 1098

Query: 627  KDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVA 686
              +  ++  LLL D+LL LQ +D++ +  +  +  +           V+ L   + REVA
Sbjct: 1099 TGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPS-----------VISLQKLIAREVA 1147

Query: 687  TDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGS 728
             + +  +++       ++YE+   +  ER NW   I +   S
Sbjct: 1148 NEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVES 1189


>gi|38373682 pleckstrin homology domain containing family G member 5
           isoform a [Homo sapiens]
          Length = 1006

 Score =  136 bits (343), Expect = 7e-32
 Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%)

Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 423
           WREL+  D    L + Q  +QE + ELL TEA+++R LRV+ +LF      C    L+E 
Sbjct: 320 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 372

Query: 424 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 471
                   + +F ++ E+ ++H     S+    L K R+    L  + GD L  +     
Sbjct: 373 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 428

Query: 472 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 531
           GS F K   R+C  +   +E ++   R +  F A++  AE  P+C+RL+L DM+    QR
Sbjct: 429 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 487

Query: 532 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
           LTKYPLLL+S+ + TEEP  +E V          +HHVN  +R  ++  RL     R+D 
Sbjct: 488 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 547

Query: 592 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 637
             + +SS    D +L EF +LD+T           ++L+ EG L  +  KD  ++V+  L
Sbjct: 548 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 607

Query: 638 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 697
             DLLL+ +       +K   RT         ++RP L +   + RE+  D  +F +++ 
Sbjct: 608 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 652

Query: 698 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 755
            +  + +  Y   A   +  + W   I      L       +      P  +++PL S  
Sbjct: 653 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 705

Query: 756 ENGNGGRETSPADARTE 772
           E  +   E    +   E
Sbjct: 706 EEEDEQEEEEEEEEEEE 722


>gi|111154084 pleckstrin homology domain containing family G member
           5 isoform b [Homo sapiens]
          Length = 1083

 Score =  136 bits (343), Expect = 7e-32
 Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%)

Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 423
           WREL+  D    L + Q  +QE + ELL TEA+++R LRV+ +LF      C    L+E 
Sbjct: 397 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 449

Query: 424 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 471
                   + +F ++ E+ ++H     S+    L K R+    L  + GD L  +     
Sbjct: 450 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 505

Query: 472 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 531
           GS F K   R+C  +   +E ++   R +  F A++  AE  P+C+RL+L DM+    QR
Sbjct: 506 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 564

Query: 532 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
           LTKYPLLL+S+ + TEEP  +E V          +HHVN  +R  ++  RL     R+D 
Sbjct: 565 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 624

Query: 592 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 637
             + +SS    D +L EF +LD+T           ++L+ EG L  +  KD  ++V+  L
Sbjct: 625 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 684

Query: 638 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 697
             DLLL+ +       +K   RT         ++RP L +   + RE+  D  +F +++ 
Sbjct: 685 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 729

Query: 698 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 755
            +  + +  Y   A   +  + W   I      L       +      P  +++PL S  
Sbjct: 730 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 782

Query: 756 ENGNGGRETSPADARTE 772
           E  +   E    +   E
Sbjct: 783 EEEDEQEEEEEEEEEEE 799


>gi|111154088 pleckstrin homology domain containing family G member
           5 isoform a [Homo sapiens]
          Length = 1006

 Score =  136 bits (343), Expect = 7e-32
 Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%)

Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 423
           WREL+  D    L + Q  +QE + ELL TEA+++R LRV+ +LF      C    L+E 
Sbjct: 320 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 372

Query: 424 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 471
                   + +F ++ E+ ++H     S+    L K R+    L  + GD L  +     
Sbjct: 373 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 428

Query: 472 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 531
           GS F K   R+C  +   +E ++   R +  F A++  AE  P+C+RL+L DM+    QR
Sbjct: 429 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 487

Query: 532 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
           LTKYPLLL+S+ + TEEP  +E V          +HHVN  +R  ++  RL     R+D 
Sbjct: 488 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 547

Query: 592 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 637
             + +SS    D +L EF +LD+T           ++L+ EG L  +  KD  ++V+  L
Sbjct: 548 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 607

Query: 638 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 697
             DLLL+ +       +K   RT         ++RP L +   + RE+  D  +F +++ 
Sbjct: 608 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 652

Query: 698 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 755
            +  + +  Y   A   +  + W   I      L       +      P  +++PL S  
Sbjct: 653 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 705

Query: 756 ENGNGGRETSPADARTE 772
           E  +   E    +   E
Sbjct: 706 EEEDEQEEEEEEEEEEE 722


>gi|111154080 pleckstrin homology domain containing family G member
           5 isoform a [Homo sapiens]
          Length = 1006

 Score =  136 bits (343), Expect = 7e-32
 Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%)

Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 423
           WREL+  D    L + Q  +QE + ELL TEA+++R LRV+ +LF      C    L+E 
Sbjct: 320 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 372

Query: 424 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 471
                   + +F ++ E+ ++H     S+    L K R+    L  + GD L  +     
Sbjct: 373 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 428

Query: 472 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 531
           GS F K   R+C  +   +E ++   R +  F A++  AE  P+C+RL+L DM+    QR
Sbjct: 429 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 487

Query: 532 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
           LTKYPLLL+S+ + TEEP  +E V          +HHVN  +R  ++  RL     R+D 
Sbjct: 488 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 547

Query: 592 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 637
             + +SS    D +L EF +LD+T           ++L+ EG L  +  KD  ++V+  L
Sbjct: 548 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 607

Query: 638 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 697
             DLLL+ +       +K   RT         ++RP L +   + RE+  D  +F +++ 
Sbjct: 608 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 652

Query: 698 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 755
            +  + +  Y   A   +  + W   I      L       +      P  +++PL S  
Sbjct: 653 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 705

Query: 756 ENGNGGRETSPADARTE 772
           E  +   E    +   E
Sbjct: 706 EEEDEQEEEEEEEEEEE 722


>gi|111154078 pleckstrin homology domain containing family G member
           5 isoform c [Homo sapiens]
          Length = 1062

 Score =  136 bits (343), Expect = 7e-32
 Identities = 123/437 (28%), Positives = 200/437 (45%), Gaps = 63/437 (14%)

Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEE- 423
           WREL+  D    L + Q  +QE + ELL TEA+++R LRV+ +LF      C    L+E 
Sbjct: 376 WRELI--DGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFL-----CCLLNLQES 428

Query: 424 -------LQNIFPSLDELIEVH-----SLFLDRLMKRRQESGYLIEEIGDVLLARFDGAE 471
                   + +F ++ E+ ++H     S+    L K R+    L  + GD L  +     
Sbjct: 429 GLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALL--QPGDFL--KGFKMF 484

Query: 472 GSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQR 531
           GS F K   R+C  +   +E ++   R +  F A++  AE  P+C+RL+L DM+    QR
Sbjct: 485 GSLF-KPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQR 543

Query: 532 LTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
           LTKYPLLL+S+ + TEEP  +E V          +HHVN  +R  ++  RL     R+D 
Sbjct: 544 LTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDA 603

Query: 592 SHLRQSS----DPMLSEFKNLDIT----------KKKLVHEGPLTWRVTKDKAVEVHVLL 637
             + +SS    D +L EF +LD+T           ++L+ EG L  +  KD  ++V+  L
Sbjct: 604 YEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFL 663

Query: 638 LDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFT 697
             DLLL+ +       +K   RT         ++RP L +   + RE+  D  +F +++ 
Sbjct: 664 FTDLLLVTK------AVKKAERT--------RVIRPPLLVDKIVCREL-RDPGSFLLIYL 708

Query: 698 WDQEAQI--YELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSS 755
            +  + +  Y   A   +  + W   I      L       +      P  +++PL S  
Sbjct: 709 NEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQL-------QQLRAQEPPGSQQPLQSLE 761

Query: 756 ENGNGGRETSPADARTE 772
           E  +   E    +   E
Sbjct: 762 EEEDEQEEEEEEEEEEE 778


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score =  114 bits (286), Expect = 3e-25
 Identities = 94/367 (25%), Positives = 172/367 (46%), Gaps = 15/367 (4%)

Query: 355  LELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMA 414
            +++  +  P  +      TL ++   + KRQ  I EL+ TE  ++  L+++ ++F + MA
Sbjct: 1154 VKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1213

Query: 415  ECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEG 472
            E  F    E+  IF +  ELI  ++  L  L  R++  G    ++ IGD+L A     + 
Sbjct: 1214 ESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA 1273

Query: 473  SWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRL 532
                    RFCS Q      L+ K  +D  F  F+++  S PRC+ + L   +   MQR+
Sbjct: 1274 Y------IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRI 1327

Query: 533  TKYPLLLQSIGQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
            T+YPLL++SI +NT E   +   ++LA E   E+   VN+ VR+ E+  RL+  Q  +  
Sbjct: 1328 TRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQC 1387

Query: 592  SHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDER 651
              L   ++ ++       +  +KL+H G L ++   +K  E+H  L +D LLL     + 
Sbjct: 1388 EGL---AEQLIFNSLTNCLGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQF 1441

Query: 652  LLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQT 711
             +     +  +   + +  +       + +  ++ TD  +   +F      ++Y L    
Sbjct: 1442 AVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDN 1501

Query: 712  VSERKNW 718
            ++ER  W
Sbjct: 1502 INERTAW 1508


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score =  114 bits (286), Expect = 3e-25
 Identities = 94/367 (25%), Positives = 172/367 (46%), Gaps = 15/367 (4%)

Query: 355  LELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMA 414
            +++  +  P  +      TL ++   + KRQ  I EL+ TE  ++  L+++ ++F + MA
Sbjct: 1181 VKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1240

Query: 415  ECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEG 472
            E  F    E+  IF +  ELI  ++  L  L  R++  G    ++ IGD+L A     + 
Sbjct: 1241 ESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA 1300

Query: 473  SWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRL 532
                    RFCS Q      L+ K  +D  F  F+++  S PRC+ + L   +   MQR+
Sbjct: 1301 Y------IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRI 1354

Query: 533  TKYPLLLQSIGQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
            T+YPLL++SI +NT E   +   ++LA E   E+   VN+ VR+ E+  RL+  Q  +  
Sbjct: 1355 TRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQC 1414

Query: 592  SHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDER 651
              L   ++ ++       +  +KL+H G L ++   +K  E+H  L +D LLL     + 
Sbjct: 1415 EGL---AEQLIFNSLTNCLGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQF 1468

Query: 652  LLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQT 711
             +     +  +   + +  +       + +  ++ TD  +   +F      ++Y L    
Sbjct: 1469 AVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDN 1528

Query: 712  VSERKNW 718
            ++ER  W
Sbjct: 1529 INERTAW 1535


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score =  111 bits (277), Expect = 3e-24
 Identities = 95/348 (27%), Positives = 168/348 (48%), Gaps = 16/348 (4%)

Query: 374  LHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDE 433
            L  L  ++ KRQ  I EL+VTE  +V  L+++ ++F +P+ E      +E+  IF +  E
Sbjct: 1228 LDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKE 1287

Query: 434  LIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALE 491
            LI  +   L  L  R++ SG    ++ IGD+L A+    +         RFCSRQ     
Sbjct: 1288 LIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPY------IRFCSRQLNGAA 1341

Query: 492  QLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNT-EEPT 550
             ++ K  + P F  FV+     PRC+ + L   I   MQR+T+YPL++++I +NT E   
Sbjct: 1342 LIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHP 1401

Query: 551  EREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDI 610
            +   ++ A E   E+   VN+ VR+ E+  RL+  Q  +    L   S+ ++       +
Sbjct: 1402 DHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---SEQLVFNSVTNCL 1458

Query: 611  TKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTM 670
              +K +H G L ++   +K  E++  L +D LLL Q   + L      +  +P  + +  
Sbjct: 1459 GPRKFLHSGKL-YKAKSNK--ELYGFLFNDFLLLTQ-ITKPLGSSGTDKVFSPKSNLQYK 1514

Query: 671  LRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNW 718
            +       + +  ++ TD      +F      ++Y L A++++ER  W
Sbjct: 1515 MYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAW 1562


>gi|222080070 pleckstrin homology domain-containing family G member
           6 isoform b [Homo sapiens]
          Length = 758

 Score =  103 bits (256), Expect = 9e-22
 Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 43/328 (13%)

Query: 348 GEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHD 407
           GE G SGL +E      WRELVP      + +    +QE + ELL TE  +VR L+++ D
Sbjct: 100 GEGGDSGLTIEKS----WRELVPGHK--EMSQELCHQQEALWELLTTELIYVRKLKIMTD 153

Query: 408 LFFQPMAECLFFPL---EELQNIFPSLDELIEVHSLFLDRLM----KRRQESGYLIEEIG 460
           L    +       L      + +F ++  LI  H  F D ++    +  + SG  ++ IG
Sbjct: 154 LLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG 213

Query: 461 DVLLARFDGAEGSWFQKISSRF------CSRQSFALEQLKAKQRKDPRFCAFVQEAESRP 514
                       S F     RF      C R    +   + +Q  +P F AFVQ  E   
Sbjct: 214 ----------LQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHK 263

Query: 515 RCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVR 574
           R  R  L D++    QR+TKYPLLL ++ + + E   +E +    E     L H+N  VR
Sbjct: 264 RSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVR 323

Query: 575 DMEDLLRLKDYQRRL-DLSHLRQSSDPM---LSEFKNLDITK----------KKLVHEGP 620
             E+   L    +R+     L   SD +   L  F  LD+T           ++L+ EGP
Sbjct: 324 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 383

Query: 621 LTWRVTKDKAVEVHVLLLDDLLLLLQRQ 648
           +  +  ++  ++V++ L  D+LL+ + Q
Sbjct: 384 VRVKEGREGKLDVYLFLFSDVLLVTKPQ 411


>gi|222080068 pleckstrin homology domain-containing family G member
           6 isoform a [Homo sapiens]
          Length = 790

 Score =  103 bits (256), Expect = 9e-22
 Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 43/328 (13%)

Query: 348 GEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHD 407
           GE G SGL +E      WRELVP      + +    +QE + ELL TE  +VR L+++ D
Sbjct: 132 GEGGDSGLTIEKS----WRELVPGHK--EMSQELCHQQEALWELLTTELIYVRKLKIMTD 185

Query: 408 LFFQPMAECLFFPL---EELQNIFPSLDELIEVHSLFLDRLM----KRRQESGYLIEEIG 460
           L    +       L      + +F ++  LI  H  F D ++    +  + SG  ++ IG
Sbjct: 186 LLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG 245

Query: 461 DVLLARFDGAEGSWFQKISSRF------CSRQSFALEQLKAKQRKDPRFCAFVQEAESRP 514
                       S F     RF      C R    +   + +Q  +P F AFVQ  E   
Sbjct: 246 ----------LQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHK 295

Query: 515 RCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVR 574
           R  R  L D++    QR+TKYPLLL ++ + + E   +E +    E     L H+N  VR
Sbjct: 296 RSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVR 355

Query: 575 DMEDLLRLKDYQRRL-DLSHLRQSSDPM---LSEFKNLDITK----------KKLVHEGP 620
             E+   L    +R+     L   SD +   L  F  LD+T           ++L+ EGP
Sbjct: 356 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 415

Query: 621 LTWRVTKDKAVEVHVLLLDDLLLLLQRQ 648
           +  +  ++  ++V++ L  D+LL+ + Q
Sbjct: 416 VRVKEGREGKLDVYLFLFSDVLLVTKPQ 443


>gi|222080066 pleckstrin homology domain-containing family G member
           6 isoform a [Homo sapiens]
          Length = 790

 Score =  103 bits (256), Expect = 9e-22
 Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 43/328 (13%)

Query: 348 GEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHD 407
           GE G SGL +E      WRELVP      + +    +QE + ELL TE  +VR L+++ D
Sbjct: 132 GEGGDSGLTIEKS----WRELVPGHK--EMSQELCHQQEALWELLTTELIYVRKLKIMTD 185

Query: 408 LFFQPMAECLFFPL---EELQNIFPSLDELIEVHSLFLDRLM----KRRQESGYLIEEIG 460
           L    +       L      + +F ++  LI  H  F D ++    +  + SG  ++ IG
Sbjct: 186 LLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG 245

Query: 461 DVLLARFDGAEGSWFQKISSRF------CSRQSFALEQLKAKQRKDPRFCAFVQEAESRP 514
                       S F     RF      C R    +   + +Q  +P F AFVQ  E   
Sbjct: 246 ----------LQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHK 295

Query: 515 RCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVR 574
           R  R  L D++    QR+TKYPLLL ++ + + E   +E +    E     L H+N  VR
Sbjct: 296 RSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVR 355

Query: 575 DMEDLLRLKDYQRRL-DLSHLRQSSDPM---LSEFKNLDITK----------KKLVHEGP 620
             E+   L    +R+     L   SD +   L  F  LD+T           ++L+ EGP
Sbjct: 356 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 415

Query: 621 LTWRVTKDKAVEVHVLLLDDLLLLLQRQ 648
           +  +  ++  ++V++ L  D+LL+ + Q
Sbjct: 416 VRVKEGREGKLDVYLFLFSDVLLVTKPQ 443


>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
           [Homo sapiens]
          Length = 596

 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 91/366 (24%), Positives = 159/366 (43%), Gaps = 41/366 (11%)

Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
           W E++      SL   +++RQE I E+   E   +  L++    +  PM +      EEL
Sbjct: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 215

Query: 425 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 482
            +IF  LD  I +H   L R+ +  +  G  +E+IG +L+        SW  ++++   +
Sbjct: 216 THIFGDLDSYIPLHEDLLTRIGEATKPDG-TVEQIGHILV--------SWLPRLNAYRGY 266

Query: 483 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 542
           CS Q  A + L  ++++DPR   F+Q     P  R+L L   +     RL KYPLLL+ I
Sbjct: 267 CSNQ-LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEI 325

Query: 543 GQNTEEPTEREKVELAAEC---CREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSD 599
            ++T  P E   V+L  +     + +L  +N    + E     + Y  +L+    +Q  D
Sbjct: 326 LKHT--PKEHPDVQLLEDAILIIQGVLSDINLKKGESE----CQYYIDKLEYLDEKQ-RD 378

Query: 600 PMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSR 659
           P       ++ +K  L H       +      ++++ L  D +L+L R   R    S+  
Sbjct: 379 P------RIEASKVLLCH-----GELRSKSGHKLYIFLFQD-ILVLTRPVTRNERHSYQV 426

Query: 660 TLTPTPDGKTMLRPV----LRLTSAMTREVATDHKA---FYVLFTWDQEAQIYELVAQTV 712
              P P  + +L  +    +R+  +     +   KA   F + F     AQ + L A  V
Sbjct: 427 YRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDV 486

Query: 713 SERKNW 718
             ++ W
Sbjct: 487 FHKQQW 492


>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2
           [Homo sapiens]
          Length = 542

 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 91/366 (24%), Positives = 159/366 (43%), Gaps = 41/366 (11%)

Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
           W E++      SL   +++RQE I E+   E   +  L++    +  PM +      EEL
Sbjct: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 161

Query: 425 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 482
            +IF  LD  I +H   L R+ +  +  G  +E+IG +L+        SW  ++++   +
Sbjct: 162 THIFGDLDSYIPLHEDLLTRIGEATKPDG-TVEQIGHILV--------SWLPRLNAYRGY 212

Query: 483 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 542
           CS Q  A + L  ++++DPR   F+Q     P  R+L L   +     RL KYPLLL+ I
Sbjct: 213 CSNQ-LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEI 271

Query: 543 GQNTEEPTEREKVELAAEC---CREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSD 599
            ++T  P E   V+L  +     + +L  +N    + E     + Y  +L+    +Q  D
Sbjct: 272 LKHT--PKEHPDVQLLEDAILIIQGVLSDINLKKGESE----CQYYIDKLEYLDEKQ-RD 324

Query: 600 PMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSR 659
           P       ++ +K  L H       +      ++++ L  D +L+L R   R    S+  
Sbjct: 325 P------RIEASKVLLCH-----GELRSKSGHKLYIFLFQD-ILVLTRPVTRNERHSYQV 372

Query: 660 TLTPTPDGKTMLRPV----LRLTSAMTREVATDHKA---FYVLFTWDQEAQIYELVAQTV 712
              P P  + +L  +    +R+  +     +   KA   F + F     AQ + L A  V
Sbjct: 373 YRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDV 432

Query: 713 SERKNW 718
             ++ W
Sbjct: 433 FHKQQW 438


>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 95/375 (25%), Positives = 172/375 (45%), Gaps = 55/375 (14%)

Query: 357 LEPEEPPG---WRELVPPDTLHSLPKSQV--KRQEVISELLVTEAAHVRMLRVLHDLFFQ 411
           +E EE  G   + +L+  + +   PK     KR   + E+  TE  +   L  +   F +
Sbjct: 163 VENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLK 222

Query: 412 PMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL-IEEIGDVLLARFDGA 470
           P+    F   ++++ IF ++++L+ VH+ FL  + +     G   + ++      RF   
Sbjct: 223 PLQR--FLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERF--- 277

Query: 471 EGSWFQKISSRFCSRQSFALEQLK--AKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTE 528
                  +  R+CS+   A + L   A  R+D +    ++E   R    R  L+D++   
Sbjct: 278 ------LVYGRYCSQVESASKHLDRVAAAREDVQMK--LEECSQRANNGRFTLRDLLMVP 329

Query: 529 MQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRR 588
           MQR+ KY LLLQ + ++T+E  E+E + LA +  R++   VN+  RD E L ++ ++Q  
Sbjct: 330 MQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQ-- 387

Query: 589 LDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQ 648
           L + +L QS    L+ +      + K+  E  +T  V +   ++ +  LLD  LL+ +R+
Sbjct: 388 LSIENLDQS----LAHY-----GRPKIDGELKIT-SVERRSKMDRYAFLLDKALLICKRR 437

Query: 649 DERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT---DHKAFYVLFTW--DQEAQ 703
            +   LK                   + L S   R+ ++   D+K +  +F    DQ AQ
Sbjct: 438 GDSYDLKD-----------------FVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ 480

Query: 704 IYELVAQTVSERKNW 718
            YEL  +T   +K W
Sbjct: 481 GYELFFKTRELKKKW 495


>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
           [Homo sapiens]
          Length = 532

 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 89/372 (23%), Positives = 157/372 (42%), Gaps = 41/372 (11%)

Query: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
           W E         L   ++KRQE I EL   E   +  L++    +  PM +      +EL
Sbjct: 110 WSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQEL 169

Query: 425 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 482
             IF +LD LI +H   L +L   R+  G   E +G +L+         W   +SS   +
Sbjct: 170 NQIFGTLDSLIPLHEELLSQLRDVRKPDG-STEHVGPILV--------GWLPCLSSYDSY 220

Query: 483 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 542
           CS Q  A + L   +++D R   F+Q     P  R+L L + +     RL KYPLLL+ I
Sbjct: 221 CSNQ-VAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREI 279

Query: 543 GQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPM 601
            ++T  +  +++ +E A    + I+  +N    + E     + Y+ R  L +L +     
Sbjct: 280 LRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESE----CRYYKER--LLYLEEGQKDS 333

Query: 602 LSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQ--RQDERLLLKSHSR 659
           L     +D ++    H       +  ++ V++HV L  ++L++ +    +E+L  + + +
Sbjct: 334 L-----IDSSRVLCCH-----GELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQ 383

Query: 660 -------TLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTV 712
                   L    DG+  L   LR   +    +      F V F    ++Q + L A   
Sbjct: 384 PIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERI---KNFFRVSFKNGSQSQTHSLQANDT 440

Query: 713 SERKNWCALITE 724
             ++ W   I +
Sbjct: 441 FNKQQWLNCIRQ 452


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,574,187
Number of Sequences: 37866
Number of extensions: 2102280
Number of successful extensions: 16090
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 108
Number of HSP's successfully gapped in prelim test: 445
Number of HSP's that attempted gapping in prelim test: 12577
Number of HSP's gapped (non-prelim): 2687
length of query: 879
length of database: 18,247,518
effective HSP length: 111
effective length of query: 768
effective length of database: 14,044,392
effective search space: 10786093056
effective search space used: 10786093056
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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