Search of human proteins with 38788380

Search of human proteins with 38788380

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38788380 dehydrogenase E1 and transketolase domain
containing 1 [Homo sapiens]
         (919 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38788380 dehydrogenase E1 and transketolase domain containing...  1870   0.0  
gi|221316661 oxoglutarate dehydrogenase-like isoform a [Homo sap...   581   e-166
gi|221316665 oxoglutarate dehydrogenase-like isoform b [Homo sap...   578   e-165
gi|51873036 oxoglutarate (alpha-ketoglutarate) dehydrogenase (li...   574   e-163
gi|221316669 oxoglutarate dehydrogenase-like isoform c [Homo sap...   564   e-160
gi|51873038 oxoglutarate (alpha-ketoglutarate) dehydrogenase (li...   116   8e-26
gi|4885543 pyruvate dehydrogenase E1 alpha 2 [Homo sapiens]            46   2e-04
gi|4505685 pyruvate dehydrogenase E1 alpha 1 precursor [Homo sap...    41   0.006
gi|4557353 branched chain keto acid dehydrogenase E1 beta precur...    39   0.029
gi|34101272 branched chain keto acid dehydrogenase E1 beta precu...    39   0.029
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]    33   0.94 
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         32   2.7  
gi|28872725 proteasome 26S non-ATPase subunit 11 [Homo sapiens]        32   3.6  
gi|4557655 islet amyloid polypeptide precursor [Homo sapiens]          31   6.1  
gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a...    31   6.1  
gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b...    31   6.1  
gi|7661734 mRNA decapping enzyme [Homo sapiens]                        30   7.9  
gi|9966903 mannosidase, alpha, class 1C, member 1 [Homo sapiens]       30   7.9  

>gi|38788380 dehydrogenase E1 and transketolase domain containing 1
           [Homo sapiens]
          Length = 919

 Score = 1870 bits (4844), Expect = 0.0
 Identities = 919/919 (100%), Positives = 919/919 (100%)

Query: 1   MASATAAAARRGLGRALPLLWRGYQTERGVYGYRPRKPESREPQGALERPPVDHGLARLV 60
           MASATAAAARRGLGRALPLLWRGYQTERGVYGYRPRKPESREPQGALERPPVDHGLARLV
Sbjct: 1   MASATAAAARRGLGRALPLLWRGYQTERGVYGYRPRKPESREPQGALERPPVDHGLARLV 60

Query: 61  TVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQGPFHTAGLLNMGKEEASLEEVLV 120
           TVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQGPFHTAGLLNMGKEEASLEEVLV
Sbjct: 61  TVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQGPFHTAGLLNMGKEEASLEEVLV 120

Query: 121 YLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHLSKLMLESQEFDHFL 180
           YLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHLSKLMLESQEFDHFL
Sbjct: 121 YLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHLSKLMLESQEFDHFL 180

Query: 181 ATKFSTVKRYGGEGAESMMGFFHELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPEL 240
           ATKFSTVKRYGGEGAESMMGFFHELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPEL
Sbjct: 181 ATKFSTVKRYGGEGAESMMGFFHELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPEL 240

Query: 241 MFRKMRGLSEFPENFSATGDVLSHLTSSVDLYFGAHHPLHVTMLPNPSHLEAVNPVAVGK 300
           MFRKMRGLSEFPENFSATGDVLSHLTSSVDLYFGAHHPLHVTMLPNPSHLEAVNPVAVGK
Sbjct: 241 MFRKMRGLSEFPENFSATGDVLSHLTSSVDLYFGAHHPLHVTMLPNPSHLEAVNPVAVGK 300

Query: 301 TRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSV 360
           TRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSV
Sbjct: 301 TRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSV 360

Query: 361 HLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFR 420
           HLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFR
Sbjct: 361 HLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFR 420

Query: 421 KDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAEHLIAGGLMTQEEVSEI 480
           KDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAEHLIAGGLMTQEEVSEI
Sbjct: 421 KDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAEHLIAGGLMTQEEVSEI 480

Query: 481 KSSYYAKLNDHLNNMAHYRPPALNLQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVE 540
           KSSYYAKLNDHLNNMAHYRPPALNLQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVE
Sbjct: 481 KSSYYAKLNDHLNNMAHYRPPALNLQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVE 540

Query: 541 VPRELQMHSHLLKTHVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGT 600
           VPRELQMHSHLLKTHVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGT
Sbjct: 541 VPRELQMHSHLLKTHVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGT 600

Query: 601 FSQRHAIVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPL 660
           FSQRHAIVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPL
Sbjct: 601 FSQRHAIVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPL 660

Query: 661 WEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMC 720
           WEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMC
Sbjct: 661 WEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMC 720

Query: 721 DSAEEGVDGDTVNMFVVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQ 780
           DSAEEGVDGDTVNMFVVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQ
Sbjct: 721 DSAEEGVDGDTVNMFVVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQ 780

Query: 781 EMAPGTTFNPVIGDSSVDPKKVKTLVFCSGKHFYSLVKQRESLGAKKHDFAIIRVEELCP 840
           EMAPGTTFNPVIGDSSVDPKKVKTLVFCSGKHFYSLVKQRESLGAKKHDFAIIRVEELCP
Sbjct: 781 EMAPGTTFNPVIGDSSVDPKKVKTLVFCSGKHFYSLVKQRESLGAKKHDFAIIRVEELCP 840

Query: 841 FPLDSLQQEMSKYKHVKDHIWSQEEPQNMGPWSFVSPRFEKQLACKLRLVGRPPLPVPAV 900
           FPLDSLQQEMSKYKHVKDHIWSQEEPQNMGPWSFVSPRFEKQLACKLRLVGRPPLPVPAV
Sbjct: 841 FPLDSLQQEMSKYKHVKDHIWSQEEPQNMGPWSFVSPRFEKQLACKLRLVGRPPLPVPAV 900

Query: 901 GIGTVHLHQHEDILAKTFA 919
           GIGTVHLHQHEDILAKTFA
Sbjct: 901 GIGTVHLHQHEDILAKTFA 919


>gi|221316661 oxoglutarate dehydrogenase-like isoform a [Homo sapiens]
          Length = 1010

 Score =  581 bits (1498), Expect = e-166
 Identities = 356/910 (39%), Positives = 515/910 (56%), Gaps = 66/910 (7%)

Query: 53   DH-GLARLVTVYCEHGHKAAKINPLFTGQALLEN-VP-------------EIQALVQTLQ 97
            DH  +  L+  Y   GH  A+++PL    A L++ VP             ++Q      +
Sbjct: 113  DHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLAFYDLQEADLDKE 172

Query: 98   GPFHTAGLLNMGKEEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKET 157
                T   +   +   SL E++  L   YC  I +E   +   ++  W  ++FE      
Sbjct: 173  FQLPTTTFIGGSENTLSLREIIRRLENTYCQHIGLEFMFINDVEQCQWIRQKFETPGVMQ 232

Query: 158  FTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESMMGFFHELLKMSAYSGITDV 217
            F++EE++ L   ++ S  F+ FLA K+S+ KR+G EG E M+     ++  S+  GI +V
Sbjct: 233  FSSEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPALKTIIDKSSEMGIENV 292

Query: 218  IIGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFPENFSATGDVLSHLTSSVD-LYFGAH 276
            I+GMPHRGRLN+L  +++   E +F +     E  +  S  GDV  HL    + +    +
Sbjct: 293  ILGMPHRGRLNVLANVIRKDLEQIFCQFDPKLEAADEGS--GDVKYHLGMYHERINRVTN 350

Query: 277  HPLHVTMLPNPSHLEAVNPVAVGKTRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASF 336
              + ++++ NPSHLEAV+PV  GKT+  Q  R D           G +V+ + VHGDA+F
Sbjct: 351  RNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDAQ---------GKKVMSILVHGDAAF 401

Query: 337  CGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIH 396
             GQG+V ETF LS+LP +   G+VH++VNNQ+G+TT     RSS Y +D+ ++V   I H
Sbjct: 402  AGQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFH 461

Query: 397  VNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARK 456
            VN D PE V+    +A E++  F KDV++DL+CYR+ GHNE+DEP +T P+MYK I  + 
Sbjct: 462  VNADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHRQV 521

Query: 457  SIPDTYAEHLIAGGLMTQEEVSEIKSSY-------YAKLND-HLNNMAHYRPPALNLQAH 508
             +   YA+ LIA G +T +E  E  + Y       Y +  D  + ++ H+      L + 
Sbjct: 522  PVLKKYADKLIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKKILHIKHW------LDSP 575

Query: 509  WQGLAQPEAQ---ITTWSTGVPLDLLRFVGMKSVEVPRE-LQMHSHLLKTHVQSRMEKMM 564
            W G    + +   +T  +TG+P D+L  +G  +  VP E  ++H+ L  + +      M 
Sbjct: 576  WPGFFNVDGEPKSMTCPATGIPEDMLTHIGSVASSVPLEDFKIHTGL--SRILRGRADMT 633

Query: 565  DGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFSQRHAIVVCQETD-DTYIPLNHM 623
                +DWA AE +A GSLL +G +VRLSGQDV RGTFS RH ++  QE D  T +P+NH+
Sbjct: 634  KNRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQEVDRRTCVPMNHL 693

Query: 624  DPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPLWEAQFGDFFNGAQIIFDTFISGG 683
             P+Q  +  V NS LSE  VLGFE G ++ SP  L LWEAQFGDF N AQ I D FIS G
Sbjct: 694  WPDQAPY-TVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNTAQCIIDQFISTG 752

Query: 684  EAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDGDT----------VN 733
            +AKW+  +GIV+LLPHG +G GP+HSS R ERFLQM +   +     T           N
Sbjct: 753  QAKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYPAFTKDFEVSQLYDCN 812

Query: 734  MFVVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVI- 792
              VV+ +TPA YFH+LRRQ++  FRKPLI+ +PK LLR P A S+  +M  GT+F  VI 
Sbjct: 813  WIVVNCSTPANYFHVLRRQILLPFRKPLIIFTPKSLLRHPEAKSSFDQMVSGTSFQRVIP 872

Query: 793  --GDSSVDPKKVKTLVFCSGKHFYSLVKQRESLGAKKHDFAIIRVEELCPFPLDSLQQEM 850
              G ++  P++V+ L+FC+GK +Y LVK+R S   ++   AI R+E++ PFP D ++QE 
Sbjct: 873  EDGAAARAPEQVQRLIFCTGKVYYDLVKERSSQDLEE-KVAITRLEQISPFPFDLIKQEA 931

Query: 851  SKYKHVKDHIWSQEEPQNMGPWSFVSPRFEKQL--ACKLRLVGRPPLPVPAVGIGTVHLH 908
             KY    +  W QEE +NMG + ++SPRF   L  A  +  VGR P   PA G    HL 
Sbjct: 932  EKYPGA-ELAWCQEEHKNMGYYDYISPRFMTILRRARPIWYVGRDPAAAPATGNRNTHLV 990

Query: 909  QHEDILAKTF 918
              +  L   F
Sbjct: 991  SLKKFLDTAF 1000


>gi|221316665 oxoglutarate dehydrogenase-like isoform b [Homo
           sapiens]
          Length = 953

 Score =  578 bits (1491), Expect = e-165
 Identities = 353/901 (39%), Positives = 512/901 (56%), Gaps = 65/901 (7%)

Query: 61  TVYCEHGHKAAKINPLFTGQALLEN-VP-------------EIQALVQTLQGPFHTAGLL 106
           +V+   GH  A+++PL    A L++ VP             ++Q      +    T   +
Sbjct: 65  SVHKIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLAFYDLQEADLDKEFQLPTTTFI 124

Query: 107 NMGKEEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHL 166
              +   SL E++  L   YC  I +E   +   ++  W  ++FE      F++EE++ L
Sbjct: 125 GGSENTLSLREIIRRLENTYCQHIGLEFMFINDVEQCQWIRQKFETPGVMQFSSEEKRTL 184

Query: 167 SKLMLESQEFDHFLATKFSTVKRYGGEGAESMMGFFHELLKMSAYSGITDVIIGMPHRGR 226
              ++ S  F+ FLA K+S+ KR+G EG E M+     ++  S+  GI +VI+GMPHRGR
Sbjct: 185 LARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPALKTIIDKSSEMGIENVILGMPHRGR 244

Query: 227 LNLLTGLLQFPPELMFRKMRGLSEFPENFSATGDVLSHLTSSVD-LYFGAHHPLHVTMLP 285
           LN+L  +++   E +F +     E  +  S  GDV  HL    + +    +  + ++++ 
Sbjct: 245 LNVLANVIRKDLEQIFCQFDPKLEAADEGS--GDVKYHLGMYHERINRVTNRNITLSLVA 302

Query: 286 NPSHLEAVNPVAVGKTRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPET 345
           NPSHLEAV+PV  GKT+  Q  R D           G +V+ + VHGDA+F GQG+V ET
Sbjct: 303 NPSHLEAVDPVVQGKTKAEQFYRGDAQ---------GKKVMSILVHGDAAFAGQGVVYET 353

Query: 346 FTLSNLPHFRIGGSVHLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVNGDSPEEV 405
           F LS+LP +   G+VH++VNNQ+G+TT     RSS Y +D+ ++V   I HVN D PE V
Sbjct: 354 FHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNADDPEAV 413

Query: 406 VRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAEH 465
           +    +A E++  F KDV++DL+CYR+ GHNE+DEP +T P+MYK I  +  +   YA+ 
Sbjct: 414 IYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHRQVPVLKKYADK 473

Query: 466 LIAGGLMTQEEVSEIKSSY-------YAKLND-HLNNMAHYRPPALNLQAHWQGLAQPEA 517
           LIA G +T +E  E  + Y       Y +  D  + ++ H+      L + W G    + 
Sbjct: 474 LIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKKILHIKHW------LDSPWPGFFNVDG 527

Query: 518 Q---ITTWSTGVPLDLLRFVGMKSVEVPRE-LQMHSHLLKTHVQSRMEKMMDGIKLDWAT 573
           +   +T  +TG+P D+L  +G  +  VP E  ++H+ L  + +      M     +DWA 
Sbjct: 528 EPKSMTCPATGIPEDMLTHIGSVASSVPLEDFKIHTGL--SRILRGRADMTKNRTVDWAL 585

Query: 574 AEALALGSLLAQGFNVRLSGQDVGRGTFSQRHAIVVCQETD-DTYIPLNHMDPNQKGFLE 632
           AE +A GSLL +G +VRLSGQDV RGTFS RH ++  QE D  T +P+NH+ P+Q  +  
Sbjct: 586 AEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQEVDRRTCVPMNHLWPDQAPY-T 644

Query: 633 VSNSPLSEEAVLGFEYGMSIESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSG 692
           V NS LSE  VLGFE G ++ SP  L LWEAQFGDF N AQ I D FIS G+AKW+  +G
Sbjct: 645 VCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNTAQCIIDQFISTGQAKWVRHNG 704

Query: 693 IVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDGDT----------VNMFVVHPTTP 742
           IV+LLPHG +G GP+HSS R ERFLQM +   +     T           N  VV+ +TP
Sbjct: 705 IVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYPAFTKDFEVSQLYDCNWIVVNCSTP 764

Query: 743 AQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVI---GDSSVDP 799
           A YFH+LRRQ++  FRKPLI+ +PK LLR P A S+  +M  GT+F  VI   G ++  P
Sbjct: 765 ANYFHVLRRQILLPFRKPLIIFTPKSLLRHPEAKSSFDQMVSGTSFQRVIPEDGAAARAP 824

Query: 800 KKVKTLVFCSGKHFYSLVKQRESLGAKKHDFAIIRVEELCPFPLDSLQQEMSKYKHVKDH 859
           ++V+ L+FC+GK +Y LVK+R S   ++   AI R+E++ PFP D ++QE  KY    + 
Sbjct: 825 EQVQRLIFCTGKVYYDLVKERSSQDLEE-KVAITRLEQISPFPFDLIKQEAEKYPGA-EL 882

Query: 860 IWSQEEPQNMGPWSFVSPRFEKQL--ACKLRLVGRPPLPVPAVGIGTVHLHQHEDILAKT 917
            W QEE +NMG + ++SPRF   L  A  +  VGR P   PA G    HL   +  L   
Sbjct: 883 AWCQEEHKNMGYYDYISPRFMTILRRARPIWYVGRDPAAAPATGNRNTHLVSLKKFLDTA 942

Query: 918 F 918
           F
Sbjct: 943 F 943


>gi|51873036 oxoglutarate (alpha-ketoglutarate) dehydrogenase
            (lipoamide) isoform 1 precursor [Homo sapiens]
          Length = 1023

 Score =  574 bits (1480), Expect = e-163
 Identities = 360/933 (38%), Positives = 522/933 (55%), Gaps = 89/933 (9%)

Query: 42   EPQGALERPPVDH-GLARLVTVYCEHGHKAAKINPLFTGQALLENVPEIQALVQT----- 95
            E Q  +++   DH  +  L+  Y   GH  A+++PL    A L++      +  T     
Sbjct: 115  EAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGF 174

Query: 96   -------LQGPFHTAGLLNMGKEEASL--EEVLVYLNQIYCGQISIETSQLQSQDEKDWF 146
                   L   FH      +G +E++L   E++  L   YC  I +E   +   ++  W 
Sbjct: 175  YGLDESDLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWI 234

Query: 147  AKRFEELQKETFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESMMGFFHELL 206
             ++FE      FT EE++ L   ++ S  F+ FL  K+S+ KR+G EG E ++     ++
Sbjct: 235  RQKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTII 294

Query: 207  KMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFPENFSATGDVLSHLT 266
              S+ +G+  VI+GMPHRGRLN+L  +++   E +F +     E  +  S  GDV  HL 
Sbjct: 295  DKSSENGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGS--GDVKYHL- 351

Query: 267  SSVDLYFGAHHP---------LHVTMLPNPSHLEAVNPVAVGKTRGRQQSRQDGDYSPDN 317
                   G +H          + ++++ NPSHLEA +PV +GKT+  Q    D +     
Sbjct: 352  -------GMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTE----- 399

Query: 318  SAQPGDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPAERG 377
                G +V+ + +HGDA+F GQGIV ETF LS+LP +   G+VH++VNNQ+G+TT     
Sbjct: 400  ----GKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMA 455

Query: 378  RSSLYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNE 437
            RSS Y +D+ ++V   I HVN D PE V+   ++A E++  F KDV++DL+CYR+ GHNE
Sbjct: 456  RSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNE 515

Query: 438  LDEPFYTNPIMYKIIRARKSIPDTYAEHLIAGGLMTQEEVSEIKSSY-------YAKLND 490
            +DEP +T P+MYK IR +K +   YAE L++ G++ Q E  E  S Y       +A+  D
Sbjct: 516  MDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFARSKD 575

Query: 491  H-LNNMAHYRPPALNLQAHWQGLAQPEAQ---ITTWSTGVPLDLLRFVGMKSVEVPRE-L 545
              + ++ H+      L + W G    + Q   ++  STG+  D+L  +G  +  VP E  
Sbjct: 576  EKILHIKHW------LDSPWPGFFTLDGQPRSMSCPSTGLTEDILTHIGNVASSVPVENF 629

Query: 546  QMH---SHLLKTHVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFS 602
             +H   S +LKT       +M+    +DWA AE +A GSLL +G ++RLSGQDV RGTFS
Sbjct: 630  TIHGGLSRILKTR-----GEMVKNRTVDWALAEYMAFGSLLKEGIHIRLSGQDVERGTFS 684

Query: 603  QRHAIVVCQETDD-TYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPLW 661
             RH ++  Q  D  T IP+NH+ PNQ  +  V NS LSE  VLGFE G ++ SP  L LW
Sbjct: 685  HRHHVLHDQNVDKRTCIPMNHLWPNQAPY-TVCNSSLSEYGVLGFELGFAMASPNALVLW 743

Query: 662  EAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMC- 720
            EAQFGDF N AQ I D FI  G+AKW+ Q+GIV+LLPHG +G GP+HSS R ERFLQMC 
Sbjct: 744  EAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCN 803

Query: 721  -------DSAEEGVDGDTV---NMFVVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKMLL 770
                   D  E   D + +   N  VV+ +TP  +FH+LRRQ++  FRKPLI+ +PK LL
Sbjct: 804  DDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFHVLRRQILLPFRKPLIIFTPKSLL 863

Query: 771  RLPAAVSTLQEMAPGTTFNPVI---GDSSVDPKKVKTLVFCSGKHFYSLVKQRESLGAKK 827
            R P A S+  EM PGT F  VI   G ++ +P+ VK L+FC+GK +Y L ++R++     
Sbjct: 864  RHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKRLLFCTGKVYYDLTRERKARD-MV 922

Query: 828  HDFAIIRVEELCPFPLDSLQQEMSKYKHVKDHIWSQEEPQNMGPWSFVSPRFEKQL--AC 885
               AI R+E+L PFP D L +E+ KY +  +  W QEE +N G + +V PR    +  A 
Sbjct: 923  GQVAITRIEQLSPFPFDLLLKEVQKYPNA-ELAWCQEEHKNQGYYDYVKPRLRTTISRAK 981

Query: 886  KLRLVGRPPLPVPAVGIGTVHLHQHEDILAKTF 918
             +   GR P   PA G    HL + + +L   F
Sbjct: 982  PVWYAGRDPAAAPATGNKKTHLTELQRLLDTAF 1014


>gi|221316669 oxoglutarate dehydrogenase-like isoform c [Homo
           sapiens]
          Length = 801

 Score =  564 bits (1453), Expect = e-160
 Identities = 333/807 (41%), Positives = 476/807 (58%), Gaps = 51/807 (6%)

Query: 141 DEKDWFAKRFEELQKETFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESMMG 200
           ++  W  ++FE      F++EE++ L   ++ S  F+ FLA K+S+ KR+G EG E M+ 
Sbjct: 7   EQCQWIRQKFETPGVMQFSSEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIP 66

Query: 201 FFHELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFPENFSATGD 260
               ++  S+  GI +VI+GMPHRGRLN+L  +++   E +F +     E  +  S  GD
Sbjct: 67  ALKTIIDKSSEMGIENVILGMPHRGRLNVLANVIRKDLEQIFCQFDPKLEAADEGS--GD 124

Query: 261 VLSHLTSSVD-LYFGAHHPLHVTMLPNPSHLEAVNPVAVGKTRGRQQSRQDGDYSPDNSA 319
           V  HL    + +    +  + ++++ NPSHLEAV+PV  GKT+  Q  R D         
Sbjct: 125 VKYHLGMYHERINRVTNRNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDAQ------- 177

Query: 320 QPGDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPAERGRS 379
             G +V+ + VHGDA+F GQG+V ETF LS+LP +   G+VH++VNNQ+G+TT     RS
Sbjct: 178 --GKKVMSILVHGDAAFAGQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARS 235

Query: 380 SLYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELD 439
           S Y +D+ ++V   I HVN D PE V+    +A E++  F KDV++DL+CYR+ GHNE+D
Sbjct: 236 SPYPTDVARVVNAPIFHVNADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMD 295

Query: 440 EPFYTNPIMYKIIRARKSIPDTYAEHLIAGGLMTQEEVSEIKSSY-------YAKLND-H 491
           EP +T P+MYK I  +  +   YA+ LIA G +T +E  E  + Y       Y +  D  
Sbjct: 296 EPMFTQPLMYKQIHRQVPVLKKYADKLIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKK 355

Query: 492 LNNMAHYRPPALNLQAHWQGLAQPEAQ---ITTWSTGVPLDLLRFVGMKSVEVPRE-LQM 547
           + ++ H+      L + W G    + +   +T  +TG+P D+L  +G  +  VP E  ++
Sbjct: 356 ILHIKHW------LDSPWPGFFNVDGEPKSMTCPATGIPEDMLTHIGSVASSVPLEDFKI 409

Query: 548 HSHLLKTHVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFSQRHAI 607
           H+ L  + +      M     +DWA AE +A GSLL +G +VRLSGQDV RGTFS RH +
Sbjct: 410 HTGL--SRILRGRADMTKNRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHV 467

Query: 608 VVCQETD-DTYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPLWEAQFG 666
           +  QE D  T +P+NH+ P+Q  +  V NS LSE  VLGFE G ++ SP  L LWEAQFG
Sbjct: 468 LHDQEVDRRTCVPMNHLWPDQAPY-TVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFG 526

Query: 667 DFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEG 726
           DF N AQ I D FIS G+AKW+  +GIV+LLPHG +G GP+HSS R ERFLQM +   + 
Sbjct: 527 DFHNTAQCIIDQFISTGQAKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDA 586

Query: 727 VDGDT----------VNMFVVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAV 776
               T           N  VV+ +TPA YFH+LRRQ++  FRKPLI+ +PK LLR P A 
Sbjct: 587 YPAFTKDFEVSQLYDCNWIVVNCSTPANYFHVLRRQILLPFRKPLIIFTPKSLLRHPEAK 646

Query: 777 STLQEMAPGTTFNPVI---GDSSVDPKKVKTLVFCSGKHFYSLVKQRESLGAKKHDFAII 833
           S+  +M  GT+F  VI   G ++  P++V+ L+FC+GK +Y LVK+R S   ++   AI 
Sbjct: 647 SSFDQMVSGTSFQRVIPEDGAAARAPEQVQRLIFCTGKVYYDLVKERSSQDLEE-KVAIT 705

Query: 834 RVEELCPFPLDSLQQEMSKYKHVKDHIWSQEEPQNMGPWSFVSPRFEKQL--ACKLRLVG 891
           R+E++ PFP D ++QE  KY    +  W QEE +NMG + ++SPRF   L  A  +  VG
Sbjct: 706 RLEQISPFPFDLIKQEAEKYPGA-ELAWCQEEHKNMGYYDYISPRFMTILRRARPIWYVG 764

Query: 892 RPPLPVPAVGIGTVHLHQHEDILAKTF 918
           R P   PA G    HL   +  L   F
Sbjct: 765 RDPAAAPATGNRNTHLVSLKKFLDTAF 791


>gi|51873038 oxoglutarate (alpha-ketoglutarate) dehydrogenase
           (lipoamide) isoform 2 precursor [Homo sapiens]
          Length = 427

 Score =  116 bits (291), Expect = 8e-26
 Identities = 83/288 (28%), Positives = 139/288 (48%), Gaps = 34/288 (11%)

Query: 42  EPQGALERPPVDH-GLARLVTVYCEHGHKAAKINPLFTGQALLENVPEIQALVQT----- 95
           E Q  +++   DH  +  L+  Y   GH  A+++PL    A L++      +  T     
Sbjct: 115 EAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGF 174

Query: 96  -------LQGPFHTAGLLNMGKEEASL--EEVLVYLNQIYCGQISIETSQLQSQDEKDWF 146
                  L   FH      +G +E++L   E++  L   YC  I +E   +   ++  W 
Sbjct: 175 YGLDESDLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWI 234

Query: 147 AKRFEELQKETFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESMMGFFHELL 206
            ++FE      FT EE++ L   ++ S  F+ FL  K+S+ KR+G EG E ++     ++
Sbjct: 235 RQKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTII 294

Query: 207 KMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFPENFSATGDVLSHLT 266
             S+ +G+  VI+GMPHRGRLN+L  +++   E +F +     E  +    +GDV  HL 
Sbjct: 295 DKSSENGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAAD--EGSGDVKYHL- 351

Query: 267 SSVDLYFGAHH---------PLHVTMLPNPSHLEAVNPVAVGKTRGRQ 305
                  G +H          + ++++ NPSHLEA +PV +GKT+  Q
Sbjct: 352 -------GMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQ 392


>gi|4885543 pyruvate dehydrogenase E1 alpha 2 [Homo sapiens]
          Length = 388

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 46/189 (24%), Positives = 80/189 (42%), Gaps = 18/189 (9%)

Query: 322 GDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPAERGRSSL 381
           G+  ICL ++GD +   QG + E F ++ L        V +  NN  G  T  ER  +S 
Sbjct: 183 GNDEICLTLYGDGA-ANQGQIAEAFNMAALWKLPC---VFICENNLYGMGTSTERAAASP 238

Query: 382 YCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEP 441
                G  +    + V+G     V  AT+ A  Y R  +  ++++L  YR  GH+  D  
Sbjct: 239 DYYKRGNFIPG--LKVDGMDVLCVREATKFAANYCRSGKGPILMELQTYRYHGHSMSDPG 296

Query: 442 F-YTNPIMYKIIRARKSIPDTYAEHLIAGGLMTQEEVSEIKSSYYAKLND---------- 490
             Y      + +R+++       + ++   L T EE+ EI +    +++D          
Sbjct: 297 VSYRTREEIQEVRSKRDPIIILQDRMVNSKLATVEELKEIGAEVRKEIDDAAQFATTDPE 356

Query: 491 -HLNNMAHY 498
            HL  + H+
Sbjct: 357 PHLEELGHH 365


>gi|4505685 pyruvate dehydrogenase E1 alpha 1 precursor [Homo
           sapiens]
          Length = 390

 Score = 40.8 bits (94), Expect = 0.006
 Identities = 40/170 (23%), Positives = 72/170 (42%), Gaps = 7/170 (4%)

Query: 322 GDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPAERGRSSL 381
           G   +CL ++GD +   QG + E + ++ L        + +  NN+ G  T  ER  +S 
Sbjct: 185 GKDEVCLTLYGDGA-ANQGQIFEAYNMAALWKLPC---IFICENNRYGMGTSVERAAAST 240

Query: 382 YCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEP 441
                G  +    + V+G     V  ATR A  Y R  +  ++++L  YR  GH+  D  
Sbjct: 241 DYYKRGDFIPG--LRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPG 298

Query: 442 F-YTNPIMYKIIRARKSIPDTYAEHLIAGGLMTQEEVSEIKSSYYAKLND 490
             Y      + +R++        + ++   L + EE+ EI      ++ D
Sbjct: 299 VSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIED 348


>gi|4557353 branched chain keto acid dehydrogenase E1 beta precursor
           [Homo sapiens]
          Length = 392

 Score = 38.5 bits (88), Expect = 0.029
 Identities = 62/266 (23%), Positives = 110/266 (41%), Gaps = 40/266 (15%)

Query: 633 VSNSPLSEEAVLGFEYGMSIESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSG 692
           V N+PL E+ ++GF  G+++     +   E QF D+   A   FD  ++   AK+  +SG
Sbjct: 119 VFNTPLCEQGIVGFGIGIAVTGATAIA--EIQFADYIFPA---FDQIVNEA-AKYRYRSG 172

Query: 693 -------IVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDGDTVNMFVVHPTTPAQY 745
                  + I  P G  G G  + S   E F   C   +           VV P +P Q 
Sbjct: 173 DLFNCGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIK-----------VVIPRSPFQA 221

Query: 746 FHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVIGDSSVDPKKVKTL 805
             LL   +    + P I   PK+L R  A      E  P   +N  +  + V  +     
Sbjct: 222 KGLLLSCI--EDKNPCIFFEPKILYRAAA------EEVPIEPYNIPLSQAEVIQEGSDVT 273

Query: 806 VFCSGKHFYSLVKQRESLGAKKHDFA--IIRVEELCPFPLDSLQQEMSKYKHVKDHIWSQ 863
           +   G   + ++++  S+  +K   +  +I +  + P+ +D++ + + K   +   + S 
Sbjct: 274 LVAWGTQVH-VIREVASMAKEKLGVSCEVIDLRTIIPWDVDTICKSVIKTGRL---LISH 329

Query: 864 EEPQNMGPWSFVSPRFEKQLACKLRL 889
           E P   G  S +S   +++  C L L
Sbjct: 330 EAPLTGGFASEISSTVQEE--CFLNL 353


>gi|34101272 branched chain keto acid dehydrogenase E1 beta
           precursor [Homo sapiens]
          Length = 392

 Score = 38.5 bits (88), Expect = 0.029
 Identities = 62/266 (23%), Positives = 110/266 (41%), Gaps = 40/266 (15%)

Query: 633 VSNSPLSEEAVLGFEYGMSIESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSG 692
           V N+PL E+ ++GF  G+++     +   E QF D+   A   FD  ++   AK+  +SG
Sbjct: 119 VFNTPLCEQGIVGFGIGIAVTGATAIA--EIQFADYIFPA---FDQIVNEA-AKYRYRSG 172

Query: 693 -------IVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDGDTVNMFVVHPTTPAQY 745
                  + I  P G  G G  + S   E F   C   +           VV P +P Q 
Sbjct: 173 DLFNCGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIK-----------VVIPRSPFQA 221

Query: 746 FHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVIGDSSVDPKKVKTL 805
             LL   +    + P I   PK+L R  A      E  P   +N  +  + V  +     
Sbjct: 222 KGLLLSCI--EDKNPCIFFEPKILYRAAA------EEVPIEPYNIPLSQAEVIQEGSDVT 273

Query: 806 VFCSGKHFYSLVKQRESLGAKKHDFA--IIRVEELCPFPLDSLQQEMSKYKHVKDHIWSQ 863
           +   G   + ++++  S+  +K   +  +I +  + P+ +D++ + + K   +   + S 
Sbjct: 274 LVAWGTQVH-VIREVASMAKEKLGVSCEVIDLRTIIPWDVDTICKSVIKTGRL---LISH 329

Query: 864 EEPQNMGPWSFVSPRFEKQLACKLRL 889
           E P   G  S +S   +++  C L L
Sbjct: 330 EAPLTGGFASEISSTVQEE--CFLNL 353


>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
          Length = 1233

 Score = 33.5 bits (75), Expect = 0.94
 Identities = 22/101 (21%), Positives = 51/101 (50%), Gaps = 4/101 (3%)

Query: 110 KEEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHLSKL 169
           + +  L+   +Y N++   +++ E +    + EKD   KR ++++ E    E++K L K+
Sbjct: 218 RAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKD--KKRMDKVEDEL--KEKKKELGKM 273

Query: 170 MLESQEFDHFLATKFSTVKRYGGEGAESMMGFFHELLKMSA 210
           M E Q+ +  +  K S + +   +  ++     H++ K+ A
Sbjct: 274 MREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEA 314


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 32.0 bits (71), Expect = 2.7
 Identities = 47/207 (22%), Positives = 81/207 (39%), Gaps = 15/207 (7%)

Query: 9    ARRGLGRALPLLWRGYQTERGVYGYRPRKPESREPQGALERPPVDHGL-ARLVTVYCEHG 67
            A+R LG  +PL  +  + ER     R  K    E    L++    HGL A       E  
Sbjct: 1402 AQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKA---HGLLAEENRGLGERA 1458

Query: 68   HKAAKINPLFTGQALLENVPEIQALVQTLQGPFHTAGLLNMGKEEASLEEVLVYLNQIYC 127
            +   +   +   QA  + V E+ A+    +       L  + +E  S    L  +   Y 
Sbjct: 1459 NLGRQFLEVELDQAREKYVQELAAVRADAE-----TRLAEVQREAQSTARELEVMTAKYE 1513

Query: 128  G-QISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKH---LSKLMLESQEFDHFLATK 183
            G ++ +   + + Q+E+     + E+L  E F  E+ K    LSK + +S +       K
Sbjct: 1514 GAKVKVLEERQRFQEERQKLTAQVEQL--EVFQREQTKQVEELSKKLADSDQASKVQQQK 1571

Query: 184  FSTVKRYGGEGAESMMGFFHELLKMSA 210
               V+  GGE  +       +L ++ A
Sbjct: 1572 LKAVQAQGGESQQEAQRLQAQLNELQA 1598


>gi|28872725 proteasome 26S non-ATPase subunit 11 [Homo sapiens]
          Length = 422

 Score = 31.6 bits (70), Expect = 3.6
 Identities = 42/162 (25%), Positives = 68/162 (41%), Gaps = 25/162 (15%)

Query: 57  ARLVTVYCEHGHKAAKINPLFTGQALLENVPEI--QAL---VQTLQGPFHTAGLLNMGKE 111
           ARLV++Y +          L  G  LL  + ++  +AL   VQ L+   + A L N+ K 
Sbjct: 131 ARLVSLYFDTKRYQ---EALHLGSQLLRELKKMDDKALLVEVQLLESKTYHA-LSNLPKA 186

Query: 112 EASLEEVLVYLNQIYC-----GQISIETSQLQSQDEKDW------FAKRFEELQK----E 156
            A+L       N IYC       + +++  + + +EKDW      F + FE        +
Sbjct: 187 RAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPK 246

Query: 157 TFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESM 198
             T+ +   L K+ML + E D           RY G   E++
Sbjct: 247 AITSLKYMLLCKIMLNTPE-DVQALVSGKLALRYAGRQTEAL 287


>gi|4557655 islet amyloid polypeptide precursor [Homo sapiens]
          Length = 89

 Score = 30.8 bits (68), Expect = 6.1
 Identities = 21/75 (28%), Positives = 36/75 (48%), Gaps = 6/75 (8%)

Query: 549 SHLLKTHVQSRMEKMMDGIKLDWATAEALALGSLL---AQGFNVRLSGQDVGRGTFSQRH 605
           +HL  T ++S     ++  K + AT     L + L   +  F   LS  +VG  T+ +R+
Sbjct: 18  NHLKATPIESHQ---VEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRN 74

Query: 606 AIVVCQETDDTYIPL 620
           A+ V +     Y+PL
Sbjct: 75  AVEVLKREPLNYLPL 89


>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
           [Homo sapiens]
          Length = 1071

 Score = 30.8 bits (68), Expect = 6.1
 Identities = 25/80 (31%), Positives = 42/80 (52%), Gaps = 4/80 (5%)

Query: 114 SLEEVLVYLNQIYCGQISIETSQLQSQD-EKDWFAKRFEELQKETFTTE-ERKH--LSKL 169
           S+E V   +++ +  + SI   +   Q+ E+ +F K  E L+     T+ + KH  L K 
Sbjct: 418 SMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKT 477

Query: 170 MLESQEFDHFLATKFSTVKR 189
           + ESQ  D  LA + STV++
Sbjct: 478 LGESQRTDCSLARRSSTVRK 497


>gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b
           [Homo sapiens]
          Length = 836

 Score = 30.8 bits (68), Expect = 6.1
 Identities = 25/80 (31%), Positives = 42/80 (52%), Gaps = 4/80 (5%)

Query: 114 SLEEVLVYLNQIYCGQISIETSQLQSQD-EKDWFAKRFEELQKETFTTE-ERKH--LSKL 169
           S+E V   +++ +  + SI   +   Q+ E+ +F K  E L+     T+ + KH  L K 
Sbjct: 418 SMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKT 477

Query: 170 MLESQEFDHFLATKFSTVKR 189
           + ESQ  D  LA + STV++
Sbjct: 478 LGESQRTDCSLARRSSTVRK 497


>gi|7661734 mRNA decapping enzyme [Homo sapiens]
          Length = 337

 Score = 30.4 bits (67), Expect = 7.9
 Identities = 30/110 (27%), Positives = 45/110 (40%), Gaps = 7/110 (6%)

Query: 403 EEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTY 462
           ++   A R+ FE        V+I  L   +W   +LD+  Y   I ++  R  +S+ D  
Sbjct: 181 DKKAEADRIVFENPDPSDGFVLIPDL---KWNQQQLDD-LYLIAICHR--RGIRSLRDLT 234

Query: 463 AEHLIAGGLMTQEEVSEIKSSYYAKLNDHLNNMAHYRPPALNLQAHWQGL 512
            EHL     +  +    I   Y  K  DHL    HY P   +L  H+  L
Sbjct: 235 PEHLPLLRNILHQGQEAILQRYRMK-GDHLRVYLHYLPSYYHLHVHFTAL 283


>gi|9966903 mannosidase, alpha, class 1C, member 1 [Homo sapiens]
          Length = 630

 Score = 30.4 bits (67), Expect = 7.9
 Identities = 19/74 (25%), Positives = 34/74 (45%), Gaps = 3/74 (4%)

Query: 441 PFYTNPIMYKIIRARKSIP---DTYAEHLIAGGLMTQEEVSEIKSSYYAKLNDHLNNMAH 497
           P + +P+    ++   S+    D++ E+LI   LM+ +   E K+ YY  L      + +
Sbjct: 368 PNFLSPVSGNWVQHHVSVGGLGDSFYEYLIKSWLMSGKTDMEAKNMYYEALEAIETYLLN 427

Query: 498 YRPPALNLQAHWQG 511
             P  L   A W+G
Sbjct: 428 VSPGGLTYIAEWRG 441


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,053,233
Number of Sequences: 37866
Number of extensions: 1753259
Number of successful extensions: 3946
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 3894
Number of HSP's gapped (non-prelim): 21
length of query: 919
length of database: 18,247,518
effective HSP length: 111
effective length of query: 808
effective length of database: 14,044,392
effective search space: 11347868736
effective search space used: 11347868736
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.