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Search of human proteins with 38788155
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform
1 precursor [Homo sapiens]
(475 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 983 0.0
gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform... 962 0.0
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 961 0.0
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso... 712 0.0
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ... 659 0.0
gi|52426761 gamma-aminobutyric acid (GABA) A receptor, epsilon p... 407 e-113
gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precurs... 388 e-108
gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor... 383 e-106
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 378 e-105
gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 378 e-105
gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 378 e-105
gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 378 e-105
gi|189083726 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 378 e-105
gi|189083724 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 378 e-105
gi|38327554 gamma-aminobutyric acid (GABA) A receptor, alpha 1 p... 378 e-105
gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precurso... 367 e-101
gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5 pr... 365 e-101
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s... 362 e-100
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs... 362 e-100
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p... 296 3e-80
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso... 293 3e-79
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is... 286 2e-77
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso... 286 2e-77
gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre... 285 5e-77
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is... 282 5e-76
gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo... 266 3e-71
gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens] 262 4e-70
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens] 262 6e-70
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens] 258 6e-69
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens] 258 6e-69
>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
precursor [Homo sapiens]
Length = 475
Score = 983 bits (2542), Expect = 0.0
Identities = 475/475 (100%), Positives = 475/475 (100%)
Query: 1 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK 60
MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK
Sbjct: 1 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK 60
Query: 61 VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT 120
VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT
Sbjct: 61 VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT 120
Query: 121 WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY 180
WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY
Sbjct: 121 WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY 180
Query: 181 TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQF 240
TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQF
Sbjct: 181 TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQF 240
Query: 241 SFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA 300
SFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA
Sbjct: 241 SFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA 300
Query: 301 VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV 360
VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV
Sbjct: 301 VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV 360
Query: 361 SNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGK 420
SNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGK
Sbjct: 361 SNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGK 420
Query: 421 DCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 475
DCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
Sbjct: 421 DCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 475
>gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform 3
precursor [Homo sapiens]
Length = 515
Score = 962 bits (2486), Expect = 0.0
Identities = 474/515 (92%), Positives = 475/515 (92%), Gaps = 40/515 (7%)
Query: 1 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK 60
MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK
Sbjct: 1 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK 60
Query: 61 VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT 120
VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT
Sbjct: 61 VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT 120
Query: 121 WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY 180
WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY
Sbjct: 121 WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY 180
Query: 181 TLRLTIDAECQLQLHNFPMDEHSCPLEFSSY----------------------------- 211
TLRLTIDAECQLQLHNFPMDEHSCPLEFSS+
Sbjct: 181 TLRLTIDAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPP 240
Query: 212 -----------GYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYV 260
GYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYV
Sbjct: 241 TLASRVAGISDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYV 300
Query: 261 VMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLST 320
VMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLST
Sbjct: 301 VMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLST 360
Query: 321 IARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRM 380
IARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRM
Sbjct: 361 IARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRM 420
Query: 381 FSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHG 440
FSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHG
Sbjct: 421 FSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHG 480
Query: 441 RIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 475
RIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
Sbjct: 481 RIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 515
>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
precursor [Homo sapiens]
Length = 467
Score = 961 bits (2484), Expect = 0.0
Identities = 467/475 (98%), Positives = 467/475 (98%), Gaps = 8/475 (1%)
Query: 1 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK 60
MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK
Sbjct: 1 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK 60
Query: 61 VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT 120
VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT
Sbjct: 61 VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT 120
Query: 121 WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY 180
WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY
Sbjct: 121 WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY 180
Query: 181 TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQF 240
TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQF
Sbjct: 181 TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQF 240
Query: 241 SFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA 300
SFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA
Sbjct: 241 SFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA 300
Query: 301 VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV 360
VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV
Sbjct: 301 VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV 360
Query: 361 SNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGK 420
SNRKPSKDKDKKKKNP APTIDIRPRSATIQMNNATHLQERDEEYGYECLDGK
Sbjct: 361 SNRKPSKDKDKKKKNP--------APTIDIRPRSATIQMNNATHLQERDEEYGYECLDGK 412
Query: 421 DCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 475
DCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
Sbjct: 413 DCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 467
>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
[Homo sapiens]
Length = 465
Score = 712 bits (1839), Expect = 0.0
Identities = 345/451 (76%), Positives = 389/451 (86%), Gaps = 11/451 (2%)
Query: 27 ILLLLSLYPGFTSQKSDD-DYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDI 85
+ LLL+L+ G K+DD D ED NKTWVL PK+ EGD+T ILN+LL+GYDNKLRPDI
Sbjct: 24 VFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDI 83
Query: 86 GVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKI 145
GV+PT+I TD+YVNSIGPV+ INMEYTIDI FAQTW+D RLKFNST+KVL LNSNMVGKI
Sbjct: 84 GVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKI 143
Query: 146 WIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCP 205
WIPDTFFRNS+K+DAHWITTPNR+LRIWNDGRVLYTLRLTI+AEC LQLHNFPMDEHSCP
Sbjct: 144 WIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCP 203
Query: 206 LEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVY 265
LEFSSYGYP+ EI Y+WK+ SVEV D + WRLYQF+FVGLRN+TE+ T SGDYV+M+++
Sbjct: 204 LEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIF 263
Query: 266 FDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKS 325
FDLSRRMGYFTIQTYIPC L VVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKS
Sbjct: 264 FDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKS 323
Query: 326 LPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRK-PSKDKDKKKKNPLLRMFSFK 384
LPKVSYVTAMDLFVSVCFIFVF+AL+EYGTLHYF SN+K + KD+K KN
Sbjct: 324 LPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNQKGKTATKDRKLKNK-------A 376
Query: 385 APTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHI 444
+ T + P S I MNN + QE ++YGY+CL+GKDCASFFCCFEDCRTG+WR GRIHI
Sbjct: 377 SMTPGLHPGSTLIPMNNISVPQE--DDYGYQCLEGKDCASFFCCFEDCRTGSWREGRIHI 434
Query: 445 RIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 475
RIAK+DSY+RIFFPTAF LFNLVYWV YLYL
Sbjct: 435 RIAKIDSYSRIFFPTAFALFNLVYWVGYLYL 465
>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
[Homo sapiens]
Length = 467
Score = 659 bits (1700), Expect = 0.0
Identities = 315/465 (67%), Positives = 384/465 (82%), Gaps = 18/465 (3%)
Query: 27 ILLLLSLYPGFTSQK---SDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRP 83
+LLLL L+ G ++ +D+YED +SN+ WVL PK + DVT+ILN LL YD KLRP
Sbjct: 5 LLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRP 64
Query: 84 DIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVG 143
DIG+KPT+I D+YVNSIGPV++INMEY IDIFFAQTW D RL+FNST+K+L LNSNMVG
Sbjct: 65 DIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVG 124
Query: 144 KIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHS 203
IWIPDT FRNSK A+AHWITTPN++LRIWNDG++LYTLRLTI+AECQLQLHNFPMDEHS
Sbjct: 125 LIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHS 184
Query: 204 CPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMS 263
CPL FSSYGYP+EE++Y+W+++SVE D +SWRLYQF F+GLRNTTE+V T++GDYVVM+
Sbjct: 185 CPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMT 244
Query: 264 VYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIAR 323
+YF+LSRRMGYFTIQTYIPC L VVLSWVSFWI KDA PART+LGITTVLTMTTLSTIAR
Sbjct: 245 IYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIAR 304
Query: 324 KSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDK--------DKKKKN 375
KSLP+VSYVTAMDLFV+VCF+FVF+AL+EY TL+Y+ S RKP+ K D +
Sbjct: 305 KSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDSSRWI 364
Query: 376 PLLRMFSFKAPT----IDIR-PRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFE 430
P S +AP+ +D+R P +A I +NN+ + QE ++ YECLDGKDC SFFCC+E
Sbjct: 365 P--ERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYE 422
Query: 431 DCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 475
+C++G+WR GRIHI I ++DSY+R+FFPT+F LFNLVYWV YLYL
Sbjct: 423 ECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVGYLYL 467
>gi|52426761 gamma-aminobutyric acid (GABA) A receptor, epsilon
precursor [Homo sapiens]
Length = 506
Score = 407 bits (1046), Expect = e-113
Identities = 196/453 (43%), Positives = 287/453 (63%), Gaps = 50/453 (11%)
Query: 60 KVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQ 119
K+PE + ILN +L YD+KLRP IG KPT++ ++ VNS+GP++ ++MEYTIDI F+Q
Sbjct: 67 KLPEA--SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQ 124
Query: 120 TWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVL 179
TWYD RL +N T + L LN N+V ++WIPDTFFRNSK+ H IT PN+M+RI+ DG+VL
Sbjct: 125 TWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVL 184
Query: 180 YTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQ 239
YT+R+TIDA C L + FPMD HSCPL FSS+ YP E++Y+W+ +E+ + SW+L+Q
Sbjct: 185 YTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQ 244
Query: 240 FSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKD 299
F F G+ N TE++ T GD++VM+++F++SRR GY Q Y+P ++ +LSWVSFWI +
Sbjct: 245 FDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTE 304
Query: 300 AVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYF 359
+ PARTSLGIT+VLTMTTL T +RK+ P+VSY+TA+D ++++CF+F F AL+E+ L++
Sbjct: 305 SAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFL 364
Query: 360 VSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERD----EEYGYE 415
+ N + K +P LR P I+ R + T + A Q ++ + E
Sbjct: 365 IYN------QTKAHASPKLR-----HPRINSRAHARTRARSRACARQHQEAFVCQIVTTE 413
Query: 416 CLDGKDCAS---------------------------------FFCCFEDCRTGAWRHGRI 442
DG++ S +FC DC W+ GR+
Sbjct: 414 GSDGEERPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRL 473
Query: 443 HIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 475
I + ++D+Y+R+ FP F FN++YW+ L L
Sbjct: 474 CIHVYRLDNYSRVVFPVTFFFFNVLYWLVCLNL 506
>gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precursor
[Homo sapiens]
Length = 453
Score = 388 bits (996), Expect = e-108
Identities = 208/422 (49%), Positives = 276/422 (65%), Gaps = 24/422 (5%)
Query: 65 DVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDR 124
+V+ IL+NLLEGYDN+LRP G T + TD+YV S GPV+ + MEYT+D+FF QTW D
Sbjct: 31 NVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDE 90
Query: 125 RLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRL 184
RLKF ++L LN+ MV KIW PDTFFRN KK+ AH +TTPN++ RI +G +LYT+RL
Sbjct: 91 RLKFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRL 150
Query: 185 TIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRS---SVEVGDTRSWRLYQFS 241
TI+A+C ++L NFPMD H+CPL+F SY YP+ EI+Y WK+ SVEV + S L Q+
Sbjct: 151 TINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESS-SLLQYD 209
Query: 242 FVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAV 301
+G ++E +K+ +G+YV+M+VYF L R+MGYF IQ Y PC + V+LS VSFWINK++V
Sbjct: 210 LIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESV 269
Query: 302 PARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVS 361
PART GITTVLTMTTLS AR SLPKVSY TAMD F++VCF FVFSAL+E+ ++YF +
Sbjct: 270 PARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYF-T 328
Query: 362 NRKPSKDKDKKKKNPLLRMFSFKA-PTIDI----RPRSATIQM--NNATHLQERDEEYGY 414
N + K K K + F A PT+ I P A I + ++ HL++R
Sbjct: 329 NLQTQKAKRKAQ---------FAAPPTVTISKATEPLEAEIVLHPDSKYHLKKRITSLSL 379
Query: 415 ECLDGKDCASFFCCFEDCRTGAWRHGRIHIRI---AKMDSYARIFFPTAFCLFNLVYWVS 471
+ + ++ + +K+D Y+RI FP AF FNLVYWV
Sbjct: 380 PIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQYSRILFPVAFAGFNLVYWVV 439
Query: 472 YL 473
YL
Sbjct: 440 YL 441
>gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor
[Homo sapiens]
Length = 492
Score = 383 bits (984), Expect = e-106
Identities = 209/469 (44%), Positives = 290/469 (61%), Gaps = 27/469 (5%)
Query: 27 ILLLLSLYPGFTSQKSDDDYE--DYASNKTWVLTPK----VPEGDV------TVILNNLL 74
IL L+++ PG T Q E D+ L+PK +P+ T IL+ LL
Sbjct: 16 ILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLL 75
Query: 75 EGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKV 134
+GYDN+LRP +G T + TD+YV S GPV+ +MEYTID+FF QTW+D RLKF+ +K+
Sbjct: 76 DGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKI 135
Query: 135 LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQL 194
L LN+ + KIW PDTFF N KK+ AH +TTPN++LR+ ++G +LYT+RLTI AEC + L
Sbjct: 136 LPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHL 195
Query: 195 HNFPMDEHSCPLEFSSYGYPREEIVYQW---KRSSVEVGDTRSWRLYQFSFVGLRNTTEV 251
+FPMD H+CPL+F SY Y E+VY W K SVEV S RL Q+ +G TE+
Sbjct: 196 EDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGS-RLNQYDLLGHVVGTEI 254
Query: 252 VKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITT 311
+++++G+YVVM+ +F L R++GYF IQTY+PC + V+LS VSFW+N+++VPART G+TT
Sbjct: 255 IRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTT 314
Query: 312 VLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDK 371
VLTMTTLS AR SLPKV+Y TAMD F++VC+ FVFSAL+E+ T++YF K S +
Sbjct: 315 VLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT---KRSWAWEG 371
Query: 372 KKKNPLLRMFSFKAPTIDIRPRSATIQMNNATH--LQERDEEYGYECLDGKDCASFFCCF 429
KK L M K P + S T + T+ +D E+ AS
Sbjct: 372 KKVPEALEM-KKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAAPSASSTPTI 430
Query: 430 EDCRTGAW-----RHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYL 473
+ + + ++K+D +RI FP F +FNLVYW +Y+
Sbjct: 431 IASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYV 479
>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 378 bits (970), Expect = e-105
Identities = 209/468 (44%), Positives = 288/468 (61%), Gaps = 38/468 (8%)
Query: 16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLE 75
+P S + WILLL +L Q S +D + T V T IL+ LL+
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPS---LQDELKDNTTVFTR---------ILDRLLD 51
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVL 135
GYDN+LRP +G + T + TD++V S GPV+ +MEYTID+FF Q+W D RLKF + VL
Sbjct: 52 GYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVL 111
Query: 136 RLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLH 195
RLN+ M KIW PDTFF N KK+ AH +T PN++LRI DG +LYT+RLT+ AEC + L
Sbjct: 112 RLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLE 171
Query: 196 NFPMDEHSCPLEFSSYGYPREEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVV 252
+FPMD H+CPL+F SY Y R E+VY+W R SV V + S RL Q+ +G + +V
Sbjct: 172 DFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIV 230
Query: 253 KTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTV 312
++++G+YVVM+ +F L R++GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTV
Sbjct: 231 QSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTV 290
Query: 313 LTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPS 366
LTMTTLS AR SLPKV+Y TAMD F++VC+ FVFSAL+E+ T++YF +
Sbjct: 291 LTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVV 350
Query: 367 KDKDKKKKNPLLRMFSFKAPT-IDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASF 425
+K KK K+PL++ + APT P A AT + ++ K+
Sbjct: 351 PEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKS-------ATIEPKEVKP- 402
Query: 426 FCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYL 473
T + ++K+D +RI FP F +FNLVYW +YL
Sbjct: 403 -------ETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 378 bits (970), Expect = e-105
Identities = 209/468 (44%), Positives = 288/468 (61%), Gaps = 38/468 (8%)
Query: 16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLE 75
+P S + WILLL +L Q S +D + T V T IL+ LL+
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPS---LQDELKDNTTVFTR---------ILDRLLD 51
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVL 135
GYDN+LRP +G + T + TD++V S GPV+ +MEYTID+FF Q+W D RLKF + VL
Sbjct: 52 GYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVL 111
Query: 136 RLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLH 195
RLN+ M KIW PDTFF N KK+ AH +T PN++LRI DG +LYT+RLT+ AEC + L
Sbjct: 112 RLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLE 171
Query: 196 NFPMDEHSCPLEFSSYGYPREEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVV 252
+FPMD H+CPL+F SY Y R E+VY+W R SV V + S RL Q+ +G + +V
Sbjct: 172 DFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIV 230
Query: 253 KTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTV 312
++++G+YVVM+ +F L R++GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTV
Sbjct: 231 QSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTV 290
Query: 313 LTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPS 366
LTMTTLS AR SLPKV+Y TAMD F++VC+ FVFSAL+E+ T++YF +
Sbjct: 291 LTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVV 350
Query: 367 KDKDKKKKNPLLRMFSFKAPT-IDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASF 425
+K KK K+PL++ + APT P A AT + ++ K+
Sbjct: 351 PEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKS-------ATIEPKEVKP- 402
Query: 426 FCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYL 473
T + ++K+D +RI FP F +FNLVYW +YL
Sbjct: 403 -------ETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 378 bits (970), Expect = e-105
Identities = 209/468 (44%), Positives = 288/468 (61%), Gaps = 38/468 (8%)
Query: 16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLE 75
+P S + WILLL +L Q S +D + T V T IL+ LL+
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPS---LQDELKDNTTVFTR---------ILDRLLD 51
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVL 135
GYDN+LRP +G + T + TD++V S GPV+ +MEYTID+FF Q+W D RLKF + VL
Sbjct: 52 GYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVL 111
Query: 136 RLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLH 195
RLN+ M KIW PDTFF N KK+ AH +T PN++LRI DG +LYT+RLT+ AEC + L
Sbjct: 112 RLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLE 171
Query: 196 NFPMDEHSCPLEFSSYGYPREEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVV 252
+FPMD H+CPL+F SY Y R E+VY+W R SV V + S RL Q+ +G + +V
Sbjct: 172 DFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIV 230
Query: 253 KTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTV 312
++++G+YVVM+ +F L R++GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTV
Sbjct: 231 QSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTV 290
Query: 313 LTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPS 366
LTMTTLS AR SLPKV+Y TAMD F++VC+ FVFSAL+E+ T++YF +
Sbjct: 291 LTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVV 350
Query: 367 KDKDKKKKNPLLRMFSFKAPT-IDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASF 425
+K KK K+PL++ + APT P A AT + ++ K+
Sbjct: 351 PEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKS-------ATIEPKEVKP- 402
Query: 426 FCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYL 473
T + ++K+D +RI FP F +FNLVYW +YL
Sbjct: 403 -------ETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 378 bits (970), Expect = e-105
Identities = 209/468 (44%), Positives = 288/468 (61%), Gaps = 38/468 (8%)
Query: 16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLE 75
+P S + WILLL +L Q S +D + T V T IL+ LL+
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPS---LQDELKDNTTVFTR---------ILDRLLD 51
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVL 135
GYDN+LRP +G + T + TD++V S GPV+ +MEYTID+FF Q+W D RLKF + VL
Sbjct: 52 GYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVL 111
Query: 136 RLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLH 195
RLN+ M KIW PDTFF N KK+ AH +T PN++LRI DG +LYT+RLT+ AEC + L
Sbjct: 112 RLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLE 171
Query: 196 NFPMDEHSCPLEFSSYGYPREEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVV 252
+FPMD H+CPL+F SY Y R E+VY+W R SV V + S RL Q+ +G + +V
Sbjct: 172 DFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIV 230
Query: 253 KTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTV 312
++++G+YVVM+ +F L R++GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTV
Sbjct: 231 QSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTV 290
Query: 313 LTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPS 366
LTMTTLS AR SLPKV+Y TAMD F++VC+ FVFSAL+E+ T++YF +
Sbjct: 291 LTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVV 350
Query: 367 KDKDKKKKNPLLRMFSFKAPT-IDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASF 425
+K KK K+PL++ + APT P A AT + ++ K+
Sbjct: 351 PEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKS-------ATIEPKEVKP- 402
Query: 426 FCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYL 473
T + ++K+D +RI FP F +FNLVYW +YL
Sbjct: 403 -------ETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083726 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 378 bits (970), Expect = e-105
Identities = 209/468 (44%), Positives = 288/468 (61%), Gaps = 38/468 (8%)
Query: 16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLE 75
+P S + WILLL +L Q S +D + T V T IL+ LL+
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPS---LQDELKDNTTVFTR---------ILDRLLD 51
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVL 135
GYDN+LRP +G + T + TD++V S GPV+ +MEYTID+FF Q+W D RLKF + VL
Sbjct: 52 GYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVL 111
Query: 136 RLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLH 195
RLN+ M KIW PDTFF N KK+ AH +T PN++LRI DG +LYT+RLT+ AEC + L
Sbjct: 112 RLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLE 171
Query: 196 NFPMDEHSCPLEFSSYGYPREEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVV 252
+FPMD H+CPL+F SY Y R E+VY+W R SV V + S RL Q+ +G + +V
Sbjct: 172 DFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIV 230
Query: 253 KTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTV 312
++++G+YVVM+ +F L R++GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTV
Sbjct: 231 QSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTV 290
Query: 313 LTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPS 366
LTMTTLS AR SLPKV+Y TAMD F++VC+ FVFSAL+E+ T++YF +
Sbjct: 291 LTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVV 350
Query: 367 KDKDKKKKNPLLRMFSFKAPT-IDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASF 425
+K KK K+PL++ + APT P A AT + ++ K+
Sbjct: 351 PEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKS-------ATIEPKEVKP- 402
Query: 426 FCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYL 473
T + ++K+D +RI FP F +FNLVYW +YL
Sbjct: 403 -------ETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083724 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 378 bits (970), Expect = e-105
Identities = 209/468 (44%), Positives = 288/468 (61%), Gaps = 38/468 (8%)
Query: 16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLE 75
+P S + WILLL +L Q S +D + T V T IL+ LL+
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPS---LQDELKDNTTVFTR---------ILDRLLD 51
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVL 135
GYDN+LRP +G + T + TD++V S GPV+ +MEYTID+FF Q+W D RLKF + VL
Sbjct: 52 GYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVL 111
Query: 136 RLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLH 195
RLN+ M KIW PDTFF N KK+ AH +T PN++LRI DG +LYT+RLT+ AEC + L
Sbjct: 112 RLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLE 171
Query: 196 NFPMDEHSCPLEFSSYGYPREEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVV 252
+FPMD H+CPL+F SY Y R E+VY+W R SV V + S RL Q+ +G + +V
Sbjct: 172 DFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIV 230
Query: 253 KTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTV 312
++++G+YVVM+ +F L R++GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTV
Sbjct: 231 QSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTV 290
Query: 313 LTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPS 366
LTMTTLS AR SLPKV+Y TAMD F++VC+ FVFSAL+E+ T++YF +
Sbjct: 291 LTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVV 350
Query: 367 KDKDKKKKNPLLRMFSFKAPT-IDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASF 425
+K KK K+PL++ + APT P A AT + ++ K+
Sbjct: 351 PEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKS-------ATIEPKEVKP- 402
Query: 426 FCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYL 473
T + ++K+D +RI FP F +FNLVYW +YL
Sbjct: 403 -------ETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|38327554 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 378 bits (970), Expect = e-105
Identities = 209/468 (44%), Positives = 288/468 (61%), Gaps = 38/468 (8%)
Query: 16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLE 75
+P S + WILLL +L Q S +D + T V T IL+ LL+
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPS---LQDELKDNTTVFTR---------ILDRLLD 51
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVL 135
GYDN+LRP +G + T + TD++V S GPV+ +MEYTID+FF Q+W D RLKF + VL
Sbjct: 52 GYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVL 111
Query: 136 RLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLH 195
RLN+ M KIW PDTFF N KK+ AH +T PN++LRI DG +LYT+RLT+ AEC + L
Sbjct: 112 RLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLE 171
Query: 196 NFPMDEHSCPLEFSSYGYPREEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVV 252
+FPMD H+CPL+F SY Y R E+VY+W R SV V + S RL Q+ +G + +V
Sbjct: 172 DFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIV 230
Query: 253 KTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTV 312
++++G+YVVM+ +F L R++GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTV
Sbjct: 231 QSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTV 290
Query: 313 LTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPS 366
LTMTTLS AR SLPKV+Y TAMD F++VC+ FVFSAL+E+ T++YF +
Sbjct: 291 LTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVV 350
Query: 367 KDKDKKKKNPLLRMFSFKAPT-IDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASF 425
+K KK K+PL++ + APT P A AT + ++ K+
Sbjct: 351 PEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKS-------ATIEPKEVKP- 402
Query: 426 FCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYL 473
T + ++K+D +RI FP F +FNLVYW +YL
Sbjct: 403 -------ETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precursor
[Homo sapiens]
Length = 554
Score = 367 bits (943), Expect = e-101
Identities = 182/347 (52%), Positives = 245/347 (70%), Gaps = 13/347 (3%)
Query: 67 TVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRL 126
T IL++LL+GYDN+LRP G T + TD+YV S GPV+ + MEYT+D+FF QTW D+RL
Sbjct: 49 TRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRL 108
Query: 127 KFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTI 186
K++ I++LRLN+ MV K+W PDTFFRN KK+ +H +T PN++ RI +G +LYT+RLTI
Sbjct: 109 KYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTI 168
Query: 187 DAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKR---SSVEVGDTRSWRLYQFSFV 243
AEC ++L +FPMD H+CPL+F SY YP+ E++Y W + SVEV S L Q+ +
Sbjct: 169 SAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEV-PKESSSLVQYDLI 227
Query: 244 GLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPA 303
G ++E +K+ +G+Y+VM+VYF L R+MGYF IQTYIPC + V+LS VSFWINK++VPA
Sbjct: 228 GQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPA 287
Query: 304 RTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV--- 360
RT GITTVLTMTTLS AR SLPKVSY TAMD F++VCF FVFSAL+E+ ++YF
Sbjct: 288 RTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQ 347
Query: 361 ---SNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATH 404
+ RK SK + P+ R K P ++ +A + M T+
Sbjct: 348 MEKAKRKTSKPPQEVPAAPVQRE---KHPEAPLQNTNANLNMRKRTN 391
Score = 42.0 bits (97), Expect = 0.001
Identities = 17/27 (62%), Positives = 20/27 (74%)
Query: 447 AKMDSYARIFFPTAFCLFNLVYWVSYL 473
+K+D YARI FP F FN+VYWV YL
Sbjct: 516 SKIDKYARILFPVTFGAFNMVYWVVYL 542
>gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5
precursor [Homo sapiens]
Length = 462
Score = 365 bits (937), Expect = e-101
Identities = 192/416 (46%), Positives = 268/416 (64%), Gaps = 25/416 (6%)
Query: 67 TVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRL 126
T IL+ LL+GYDN+LRP +G + T + TD+YV S GPV+ MEYTID+FF Q+W D RL
Sbjct: 50 TRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERL 109
Query: 127 KFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTI 186
+F ++ L LN+ + KIW PDTFF N KK+ AH +TTPN++LR+ +DG +LYT+RLTI
Sbjct: 110 RFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTI 169
Query: 187 DAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQW---KRSSVEVGDTRSWRLYQFSFV 243
AEC +QL +FPMD H+CPL+F SY YP E+VY W SV V + S RL Q+ +
Sbjct: 170 SAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGS-RLNQYHLM 228
Query: 244 GLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPA 303
G TE + T++G+Y +M+ +F L R++GYF IQTY+PC + V+LS VSFW+N+++VPA
Sbjct: 229 GQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPA 288
Query: 304 RTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV--- 360
RT G+TTVLTMTTLS AR SLPKV+Y TAMD F++VC+ FVFSAL+E+ T++YF
Sbjct: 289 RTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRG 348
Query: 361 ---SNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECL 417
+K + KKK ++ S A T T +M++ ++ + G
Sbjct: 349 WAWDGKKALEAAKIKKKREVILNKSTNAFT--------TGKMSHPPNIPKEQTPAG---- 396
Query: 418 DGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYL 473
+ S + +T + + + I+K+D +RI FP F FNLVYW +YL
Sbjct: 397 -TSNTTSVSVKPSEEKTSESK--KTYNSISKIDKMSRIVFPVLFGTFNLVYWATYL 449
>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
sapiens]
Length = 451
Score = 362 bits (930), Expect = e-100
Identities = 190/422 (45%), Positives = 265/422 (62%), Gaps = 38/422 (9%)
Query: 67 TVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRL 126
T IL+ LL+GYDN+LRP +G T + T++YV S GPV+ +MEYTID+FF Q W D RL
Sbjct: 43 TRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERL 102
Query: 127 KFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTI 186
KF + +LRLN+ M KIW PDTFF N KK+ AH +T PN++LRI +DG +LYT+RLT+
Sbjct: 103 KFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTV 162
Query: 187 DAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQW---KRSSVEVGDTRSWRLYQFSFV 243
AEC + L +FPMD HSCPL+F SY Y E+ Y W SV+V S RL Q+ +
Sbjct: 163 QAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGS-RLNQYDLL 221
Query: 244 GLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPA 303
G E +K+++G+Y VM+ +F L R++GYF IQTY+PC + V+LS VSFW+N+++VPA
Sbjct: 222 GQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPA 281
Query: 304 RTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV--- 360
RT G+TTVLTMTTLS AR SLPKV+Y TAMD F++VC+ FVFSAL+E+ T++YF
Sbjct: 282 RTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRG 341
Query: 361 ---SNRKPSKDKDKKKKNPLLRMFSFK------APTIDIRPRSATIQMNNATHLQERDEE 411
+ DK K+K + +++ ++ AP + P +TI + T E +++
Sbjct: 342 WAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATT--PEPNKK 399
Query: 412 YGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVS 471
+ + K + ++K+D +RI FP F FNLVYW +
Sbjct: 400 PENKPAEAK--------------------KTFNSVSKIDRMSRIVFPVLFGTFNLVYWAT 439
Query: 472 YL 473
YL
Sbjct: 440 YL 441
>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
[Homo sapiens]
Length = 451
Score = 362 bits (930), Expect = e-100
Identities = 190/422 (45%), Positives = 265/422 (62%), Gaps = 38/422 (9%)
Query: 67 TVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRL 126
T IL+ LL+GYDN+LRP +G T + T++YV S GPV+ +MEYTID+FF Q W D RL
Sbjct: 43 TRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERL 102
Query: 127 KFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTI 186
KF + +LRLN+ M KIW PDTFF N KK+ AH +T PN++LRI +DG +LYT+RLT+
Sbjct: 103 KFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTV 162
Query: 187 DAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQW---KRSSVEVGDTRSWRLYQFSFV 243
AEC + L +FPMD HSCPL+F SY Y E+ Y W SV+V S RL Q+ +
Sbjct: 163 QAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGS-RLNQYDLL 221
Query: 244 GLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPA 303
G E +K+++G+Y VM+ +F L R++GYF IQTY+PC + V+LS VSFW+N+++VPA
Sbjct: 222 GQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPA 281
Query: 304 RTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV--- 360
RT G+TTVLTMTTLS AR SLPKV+Y TAMD F++VC+ FVFSAL+E+ T++YF
Sbjct: 282 RTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRG 341
Query: 361 ---SNRKPSKDKDKKKKNPLLRMFSFK------APTIDIRPRSATIQMNNATHLQERDEE 411
+ DK K+K + +++ ++ AP + P +TI + T E +++
Sbjct: 342 WAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATT--PEPNKK 399
Query: 412 YGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVS 471
+ + K + ++K+D +RI FP F FNLVYW +
Sbjct: 400 PENKPAEAK--------------------KTFNSVSKIDRMSRIVFPVLFGTFNLVYWAT 439
Query: 472 YL 473
YL
Sbjct: 440 YL 441
>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
precursor [Homo sapiens]
Length = 474
Score = 296 bits (758), Expect = 3e-80
Identities = 170/449 (37%), Positives = 250/449 (55%), Gaps = 59/449 (13%)
Query: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129
++ LL+GYD +LRPD G P + + V SI V+ +NM+YT+ ++F Q+W D+RL ++
Sbjct: 41 VDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYS 100
Query: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A
Sbjct: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
Query: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249
C + L +P+DE +C LE SYGY ++I + W V L QFS V + +
Sbjct: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVS 220
Query: 250 EVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGI 309
+ V+ T+G Y +S+ F L R +GYF +QTY+P TLI +LSWVSFWIN DA AR +LGI
Sbjct: 221 KKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGI 280
Query: 310 TTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSK-- 367
TTVLTMTT+ST R++LPK+ YV A+D+++ CF+FVF AL+EY ++Y + P K
Sbjct: 281 TTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKG 340
Query: 368 ----DKDKKKKNPL-LRMFSFKA------PTIDIRPRS-------------ATIQMNNAT 403
D+ +KN L + A T++IR + AT+ ++
Sbjct: 341 ASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSA 400
Query: 404 HLQERD-----EEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKM--------- 449
+Q R E YG LD R G GRI R +++
Sbjct: 401 SIQYRKPLSSREAYG-RALD--------------RHGVPSKGRIRRRASQLKVKIPDLTD 445
Query: 450 ----DSYARIFFPTAFCLFNLVYWVSYLY 474
D ++R+FFP F LFN+VYW+ Y++
Sbjct: 446 VNSIDKWSRMFFPITFSLFNVVYWLYYVH 474
>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 2 [Homo sapiens]
Length = 474
Score = 293 bits (749), Expect = 3e-79
Identities = 165/449 (36%), Positives = 248/449 (55%), Gaps = 60/449 (13%)
Query: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129
++ LL+GYD +LRPD G P + ++ + SI V+ +NM+YT+ ++F Q W D+RL +N
Sbjct: 40 VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99
Query: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A
Sbjct: 100 VIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 159
Query: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249
C + L +P+DE +C LE SYGY ++I + W+ V L QFS V + T
Sbjct: 160 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLIT 219
Query: 250 EVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGI 309
+ V ++G Y +S+ F L R +GYF +QTY+P LI +LSWVSFWIN DA AR +LGI
Sbjct: 220 KKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 279
Query: 310 TTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDK 369
TTVLTMTT++T R++LPK+ YV A+D+++ CF+FVF AL+EY ++Y R P + K
Sbjct: 280 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQK 339
Query: 370 DKKKK-----NPLLRMFSFK--------APTIDIR--------------PRSATIQMNNA 402
+K N +R+ K T++I+ PRS T+ +A
Sbjct: 340 KAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRS-TMLAYDA 398
Query: 403 THLQERD-----EEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKM-------- 449
+ +Q R +G L+ R A + R+ R +++
Sbjct: 399 SSIQYRKAGLPRHSFGRNALE--------------RHVAQKKSRLRRRASQLKITIPDLT 444
Query: 450 -----DSYARIFFPTAFCLFNLVYWVSYL 473
D ++RIFFP F FN+VYW+ Y+
Sbjct: 445 DVNAIDRWSRIFFPVVFSFFNIVYWLYYV 473
>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 2 precursor [Homo sapiens]
Length = 473
Score = 286 bits (733), Expect = 2e-77
Identities = 158/437 (36%), Positives = 238/437 (54%), Gaps = 38/437 (8%)
Query: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129
++ LL+GYD +LRPD G P + ++ + SI V+ +NM+YT+ ++F Q W D+RL ++
Sbjct: 41 VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100
Query: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A
Sbjct: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
Query: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249
C + L +P+DE +C LE SYGY ++I + W+ V L QFS V R +
Sbjct: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVS 220
Query: 250 EVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGI 309
V +G Y +S+ F L R +GYF +QTY+P LI +LSWVSFWIN DA AR +LGI
Sbjct: 221 RNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 280
Query: 310 TTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDK 369
TTVLTMTT++T R++LPK+ YV A+D+++ CF+FVF AL+EY ++Y R P + K
Sbjct: 281 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQK 340
Query: 370 DKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCF 429
+K + K+ + + + + H + + G D + F
Sbjct: 341 KLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGI-----GDTRNSAISF 395
Query: 430 EDC----------RTGAWR--------HGRIHIR---------------IAKMDSYARIF 456
++ R G R H + H+R + +D ++RI
Sbjct: 396 DNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIV 455
Query: 457 FPTAFCLFNLVYWVSYL 473
FP F LFNLVYW+ Y+
Sbjct: 456 FPFTFSLFNLVYWLYYV 472
>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 1 precursor [Homo sapiens]
Length = 473
Score = 286 bits (733), Expect = 2e-77
Identities = 158/437 (36%), Positives = 238/437 (54%), Gaps = 38/437 (8%)
Query: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129
++ LL+GYD +LRPD G P + ++ + SI V+ +NM+YT+ ++F Q W D+RL ++
Sbjct: 41 VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100
Query: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A
Sbjct: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
Query: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249
C + L +P+DE +C LE SYGY ++I + W+ V L QFS V R +
Sbjct: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVS 220
Query: 250 EVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGI 309
V +G Y +S+ F L R +GYF +QTY+P LI +LSWVSFWIN DA AR +LGI
Sbjct: 221 RNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 280
Query: 310 TTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDK 369
TTVLTMTT++T R++LPK+ YV A+D+++ CF+FVF AL+EY ++Y R P + K
Sbjct: 281 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQK 340
Query: 370 DKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCF 429
+K + K+ + + + + H + + G D + F
Sbjct: 341 KLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGI-----GDTRNSAISF 395
Query: 430 EDC----------RTGAWR--------HGRIHIR---------------IAKMDSYARIF 456
++ R G R H + H+R + +D ++RI
Sbjct: 396 DNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIV 455
Query: 457 FPTAFCLFNLVYWVSYL 473
FP F LFNLVYW+ Y+
Sbjct: 456 FPFTFSLFNLVYWLYYV 472
>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
precursor [Homo sapiens]
Length = 452
Score = 285 bits (730), Expect = 5e-77
Identities = 161/416 (38%), Positives = 230/416 (55%), Gaps = 22/416 (5%)
Query: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129
L+ L+ GY RP IG P + + V SI ++ NMEYT+ +F Q+W D RL +N
Sbjct: 44 LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
Query: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
T + L L+S V K+W+PDTF N+K A H +T N+++R+ DG +LY++R+T
Sbjct: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
Query: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249
C + L +PMDE C L+ SYGY E+IVY W S + +L QF+ R TT
Sbjct: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTT 223
Query: 250 EVVK-TTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLG 308
E++ ++G + +S++F L R G + IQ+Y+P L+V +SWVSFWI++ AVPAR SLG
Sbjct: 224 ELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLG 283
Query: 309 ITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKD 368
ITTVLTMTTL AR SLP+ S + A+D++ +C++FVF+ALVEY H+ RK K
Sbjct: 284 ITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKA 343
Query: 369 KDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFC- 427
K K + P M D+R ++ A QE + G S+
Sbjct: 344 KVKVSR-PRAEM--------DVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSV 394
Query: 428 ---CFEDCRTGAWR---HGRIHIRIAKMDS-----YARIFFPTAFCLFNLVYWVSY 472
E + GA R G I R+ +D+ YAR FP AF N++YW +Y
Sbjct: 395 GVETGETKKEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 1 [Homo sapiens]
Length = 512
Score = 282 bits (721), Expect = 5e-76
Identities = 134/305 (43%), Positives = 196/305 (64%)
Query: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129
++ LL+GYD +LRPD G P + ++ + SI V+ +NM+YT+ ++F Q W D+RL +N
Sbjct: 40 VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99
Query: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A
Sbjct: 100 VIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 159
Query: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249
C + L +P+DE +C LE SYGY ++I + W+ V L QFS V + T
Sbjct: 160 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLIT 219
Query: 250 EVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGI 309
+ V ++G Y +S+ F L R +GYF +QTY+P LI +LSWVSFWIN DA AR +LGI
Sbjct: 220 KKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 279
Query: 310 TTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDK 369
TTVLTMTT++T R++LPK+ YV A+D+++ CF+FVF AL+EY ++Y R P + K
Sbjct: 280 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQK 339
Query: 370 DKKKK 374
+K
Sbjct: 340 KAAEK 344
Score = 37.4 bits (85), Expect = 0.030
Identities = 13/25 (52%), Positives = 19/25 (76%)
Query: 449 MDSYARIFFPTAFCLFNLVYWVSYL 473
+D ++RIFFP F FN+VYW+ Y+
Sbjct: 487 IDRWSRIFFPVVFSFFNIVYWLYYV 511
>gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo
sapiens]
Length = 457
Score = 266 bits (680), Expect = 3e-71
Identities = 156/414 (37%), Positives = 229/414 (55%), Gaps = 35/414 (8%)
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS-TIKV 134
GYD ++RP+ P + ++++NS G + M+Y ++IF Q W D RL +N
Sbjct: 51 GYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDS 110
Query: 135 LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQL 194
L L+ +M+ IW PD FF N K A H ITT N++LRI +G VLY++R+T+ C + L
Sbjct: 111 LDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDL 170
Query: 195 HNFPMDEHSCPLEFSSYGYPREEIVYQWK-RSSVEVGDTRSWRLYQFSFVGLRNTTEVVK 253
NFPMD +C ++ S+GY +++++W+ + +V+V D + L QF ++ K
Sbjct: 171 KNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLT--LPQFILKEEKDLRYCTK 228
Query: 254 T-TSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTV 312
+G + + F L R+MGY+ IQ YIP LIV+LSW+SFWIN DA PAR LGITTV
Sbjct: 229 HYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTV 288
Query: 313 LTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKP---SKDK 369
LTMTT S+ +R SLPKVSYV A+D++++VC +FVFSAL+EY +++ K + K
Sbjct: 289 LTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRK 348
Query: 370 DKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGY--ECLDGKDCASFFC 427
+ K+P+L +F Q + A + YG CL KD S
Sbjct: 349 RRHHKSPMLNLF----------------QEDEAGEGRFNFSAYGMGPACLQAKDGISVKG 392
Query: 428 CFEDCRT--------GAWRHGRIHI-RIAKMDSYARIFFPTAFCLFNLVYWVSY 472
T ++ I R K+D +RI FP AF +FN+ YW+ Y
Sbjct: 393 ANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIY 446
>gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]
Length = 464
Score = 262 bits (670), Expect = 4e-70
Identities = 156/426 (36%), Positives = 230/426 (53%), Gaps = 53/426 (12%)
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS-TIKV 134
GYD ++RP+ P + ++++NS G + M+Y ++IF Q W D RL ++
Sbjct: 56 GYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDS 115
Query: 135 LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQL 194
L L+ +M+ IW PD FF N K A+ H +TT N++LRI+ +G VLY++RLT+ C + L
Sbjct: 116 LDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDL 175
Query: 195 HNFPMDEHSCPLEFSSYGYPREEIVYQWK-RSSVEVGDTRSWRLYQFSFVGLRNTTEVVK 253
NFPMD +C ++ S+GY +++++W+ + V+V + + L QF ++ K
Sbjct: 176 KNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLT--LPQFLLKEEKDLRYCTK 233
Query: 254 T-TSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTV 312
+G + + V F L R+MGY+ IQ YIP LIV+LSWVSFWIN DA PAR +LGITTV
Sbjct: 234 HYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTV 293
Query: 313 LTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKP-----SK 367
LTMTT S+ +R SLPKVSYV A+D++++VC +FVFSAL+EY +++ K K
Sbjct: 294 LTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRK 353
Query: 368 DKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGY-ECLDGKDCASFF 426
K+K + L + + F ++R + YG CL KD
Sbjct: 354 RKNKTEAFALEKFYRFSDMDDEVRESRFSF------------TAYGMGPCLQAKD----- 396
Query: 427 CCFEDCRTGAWRHGRIH-----------------IRIAKMDSYARIFFPTAFCLFNLVYW 469
G G H R K+D+ +R FP AF +FN+ YW
Sbjct: 397 --------GMTPKGPNHPVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYW 448
Query: 470 VSYLYL 475
V Y L
Sbjct: 449 VIYKIL 454
>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
Length = 449
Score = 262 bits (669), Expect = 6e-70
Identities = 152/412 (36%), Positives = 228/412 (55%), Gaps = 40/412 (9%)
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS-TIKV 134
GYD ++RP+ P + ++++NS G + M+Y ++IF Q W D RL ++
Sbjct: 56 GYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDS 115
Query: 135 LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQL 194
L L+ +M+ IW PD FF N K A+ H +TT N++LRI+ +G VLY++RLT+ C + L
Sbjct: 116 LDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDL 175
Query: 195 HNFPMDEHSCPLEFSSYGYPREEIVYQWK-RSSVEVGDTRSWRLYQFSFVGLRNTTEVVK 253
NFPMD +C ++ S+GY +++++W+ + V+V + + L QF ++ K
Sbjct: 176 KNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLT--LPQFLLKEEKDLRYCTK 233
Query: 254 T-TSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTV 312
+G + + V F L R+MGY+ IQ YIP LIV+LSWVSFWIN DA PAR +LGITTV
Sbjct: 234 HYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTV 293
Query: 313 LTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKK 372
LTMTT S+ +R SLPKVSYV A+D++++VC +FVFSAL+EY +++ K +K
Sbjct: 294 LTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRK 353
Query: 373 KKNP----LLRMFSFKA----PTIDIRPRSATIQMNNATHLQERD-EEYGYECLDGKDCA 423
+KN FSF A P + + N+ + + +E +D
Sbjct: 354 RKNKDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKVFID----- 408
Query: 424 SFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 475
R K+D+ +R FP AF +FN+ YWV Y L
Sbjct: 409 ---------------------RAKKIDTISRACFPLAFLIFNIFYWVIYKIL 439
>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 258 bits (660), Expect = 6e-69
Identities = 150/412 (36%), Positives = 225/412 (54%), Gaps = 42/412 (10%)
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS-TIKV 134
GYD ++RP+ P + ++++NS G V M+Y ++IF Q W D RL ++
Sbjct: 57 GYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDS 116
Query: 135 LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQL 194
L L+ +M+ IW PD FF N K A+ H +TT N++LRI +G+VLY++RLT+ C + L
Sbjct: 117 LDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDL 176
Query: 195 HNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKT 254
NFPMD +C ++ S+GY +++++W S V L QF + K
Sbjct: 177 KNFPMDVQTCTMQLESFGYTMNDLIFEWL-SDGPVQVAEGLTLPQFILKEEKELGYCTKH 235
Query: 255 -TSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVL 313
+G + + V F L R+MGY+ IQ YIP LIV+LSWVSFWIN DA PAR +LGITTVL
Sbjct: 236 YNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVL 295
Query: 314 TMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHY-------FVSNRKPS 366
TMTT S+ +R SLPKVSYV A+D++++VC +FVF+AL+EY +++ F+ R+
Sbjct: 296 TMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQ 355
Query: 367 KDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGY-ECLDGKDCASF 425
K ++K++ F+F YG CL KD +
Sbjct: 356 KRQNKEEDVTRESRFNFSG--------------------------YGMGHCLQVKDGTAV 389
Query: 426 FC-----CFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSY 472
+ + G + R ++D+ +R FP AF +FN+ YW++Y
Sbjct: 390 KATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITY 441
>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 258 bits (660), Expect = 6e-69
Identities = 150/412 (36%), Positives = 225/412 (54%), Gaps = 42/412 (10%)
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS-TIKV 134
GYD ++RP+ P + ++++NS G V M+Y ++IF Q W D RL ++
Sbjct: 57 GYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDS 116
Query: 135 LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQL 194
L L+ +M+ IW PD FF N K A+ H +TT N++LRI +G+VLY++RLT+ C + L
Sbjct: 117 LDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDL 176
Query: 195 HNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKT 254
NFPMD +C ++ S+GY +++++W S V L QF + K
Sbjct: 177 KNFPMDVQTCTMQLESFGYTMNDLIFEWL-SDGPVQVAEGLTLPQFILKEEKELGYCTKH 235
Query: 255 -TSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVL 313
+G + + V F L R+MGY+ IQ YIP LIV+LSWVSFWIN DA PAR +LGITTVL
Sbjct: 236 YNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVL 295
Query: 314 TMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHY-------FVSNRKPS 366
TMTT S+ +R SLPKVSYV A+D++++VC +FVF+AL+EY +++ F+ R+
Sbjct: 296 TMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQ 355
Query: 367 KDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGY-ECLDGKDCASF 425
K ++K++ F+F YG CL KD +
Sbjct: 356 KRQNKEEDVTRESRFNFSG--------------------------YGMGHCLQVKDGTAV 389
Query: 426 FC-----CFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSY 472
+ + G + R ++D+ +R FP AF +FN+ YW++Y
Sbjct: 390 KATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITY 441
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.137 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,773,906
Number of Sequences: 37866
Number of extensions: 761813
Number of successful extensions: 2110
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 1946
Number of HSP's gapped (non-prelim): 100
length of query: 475
length of database: 18,247,518
effective HSP length: 106
effective length of query: 369
effective length of database: 14,233,722
effective search space: 5252243418
effective search space used: 5252243418
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.