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Search of human proteins with 38505294
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38505294 voltage-dependent calcium channel alpha 1G subunit
isoform 15 [Homo sapiens]
(1555 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38505294 voltage-dependent calcium channel alpha 1G subunit i... 3140 0.0
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i... 2976 0.0
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i... 2976 0.0
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i... 2976 0.0
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i... 2976 0.0
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 2976 0.0
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i... 2976 0.0
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 2919 0.0
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i... 2919 0.0
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 2919 0.0
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i... 2919 0.0
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i... 2919 0.0
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 2919 0.0
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i... 2919 0.0
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i... 2919 0.0
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 1612 0.0
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H... 1612 0.0
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I... 818 0.0
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I... 818 0.0
gi|37622907 voltage-gated sodium channel type V alpha isoform a ... 268 4e-71
gi|150417969 voltage-gated sodium channel type V alpha isoform d... 268 4e-71
gi|150417967 voltage-gated sodium channel type V alpha isoform c... 268 4e-71
gi|237512980 voltage-gated sodium channel type V alpha isoform e... 266 1e-70
gi|30089970 voltage-gated sodium channel type V alpha isoform b ... 266 1e-70
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ... 175 3e-43
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E... 175 3e-43
gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F... 165 3e-40
gi|110349767 calcium channel, voltage-dependent, L type, alpha 1... 160 7e-39
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s... 158 4e-38
gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo s... 158 4e-38
>gi|38505294 voltage-dependent calcium channel alpha 1G subunit
isoform 15 [Homo sapiens]
Length = 1555
Score = 3140 bits (8142), Expect = 0.0
Identities = 1555/1555 (100%), Positives = 1555/1555 (100%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQVSPRLRGGAVVKEAGGGTGPCLVIPA 1500
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQVSPRLRGGAVVKEAGGGTGPCLVIPA
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQVSPRLRGGAVVKEAGGGTGPCLVIPA 1500
Query: 1501 DSGGGGLHEEISPSHPLLSNHQHVAKPSPSHSAPKSGPMGSLAVLKDEETEAQRG 1555
DSGGGGLHEEISPSHPLLSNHQHVAKPSPSHSAPKSGPMGSLAVLKDEETEAQRG
Sbjct: 1501 DSGGGGLHEEISPSHPLLSNHQHVAKPSPSHSAPKSGPMGSLAVLKDEETEAQRG 1555
>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
isoform 1 [Homo sapiens]
Length = 2377
Score = 2976 bits (7716), Expect = 0.0
Identities = 1474/1474 (100%), Positives = 1474/1474 (100%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
Score = 108 bits (269), Expect = 5e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 1265 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1321
Query: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1442 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1501
Query: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 1502 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557
Score = 107 bits (266), Expect = 1e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 1610 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1669
Query: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 1670 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1729
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 1730 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1789
Query: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 1790 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1849
Query: 963 LVEGFQAEEISKREDA 978
L++ + +E+A
Sbjct: 1850 LMKHLEESNKEAKEEA 1865
Score = 103 bits (256), Expect = 2e-21
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
SRFRLL H + T D + +I LN +T+AME + P + L + NYIFT +F+
Sbjct: 1598 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1655
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
E K+VA FG + + + WN LD +VL+S++ I + + + + + ++R++
Sbjct: 1656 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1711
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
R+LR R L+++ A G++ +++T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1712 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1765
Score = 68.2 bits (165), Expect = 6e-11
Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 41/248 (16%)
Query: 3 EEEDGAGAEESG-----QPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALA 57
EEE+ EE + R + L+D+ +G SA SEA+ PY
Sbjct: 1548 EEEEARRREEKRLRRLEKKRRNLMLDDVIASGSS----------ASAASEAQCKPY---- 1593
Query: 58 PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
S SR R + + + VI LN VT+ M + D L
Sbjct: 1594 ------YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA----L 1643
Query: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
+ + F +E V K+VA FG + + D WN+LD IV+ ++ +L+ V+ S
Sbjct: 1644 KICNYIFTVIFVLESVFKLVA---FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1700
Query: 178 A---------VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 228
+R +R+ R L+ + MR L+ ++ LP +GN+ LL +FFIF +
Sbjct: 1701 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1760
Query: 229 GVQLWAGL 236
GV+L+ L
Sbjct: 1761 GVELFGDL 1768
Score = 61.2 bits (147), Expect = 7e-09
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822
Query: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1863
>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
isoform 10 [Homo sapiens]
Length = 2266
Score = 2976 bits (7716), Expect = 0.0
Identities = 1474/1474 (100%), Positives = 1474/1474 (100%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
Score = 108 bits (269), Expect = 5e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 1265 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1321
Query: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1442 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1501
Query: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 1502 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557
Score = 107 bits (266), Expect = 1e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 1592 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1651
Query: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 1652 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1711
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 1712 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1771
Query: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 1772 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1831
Query: 963 LVEGFQAEEISKREDA 978
L++ + +E+A
Sbjct: 1832 LMKHLEESNKEAKEEA 1847
Score = 105 bits (261), Expect = 4e-22
Identities = 67/212 (31%), Positives = 118/212 (55%), Gaps = 15/212 (7%)
Query: 1225 DDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLV 1284
++E + +R+R + R A C + +S Y SRFRLL H + T D +
Sbjct: 1549 EEEARRREEKRLRRLEKKRRKAQC--KPYYSDY-----SRFRLLVHHLCTSHYLDLFITG 1601
Query: 1285 IIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRS 1344
+I LN +T+AME + P + L + NYIFT +F+ E K+VA FG + + +
Sbjct: 1602 VIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFVLESVFKLVA----FGFRRFFQD 1655
Query: 1345 SWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLLRTLRPLRVISRAQGLKLVV 1402
WN LD +VL+S++ I + + + + + ++R++R+LR R L+++ A G++ ++
Sbjct: 1656 RWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALL 1715
Query: 1403 ETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
+T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1716 DTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1747
Score = 66.6 bits (161), Expect = 2e-10
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)
Query: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
VI LN VT+ M + D L+ + F +E V K+VA FG + +
Sbjct: 1602 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1654
Query: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
D WN+LD IV+ ++ +L+ V+ S +R +R+ R L+ + MR L
Sbjct: 1655 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1714
Query: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
+ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1715 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1750
Score = 61.2 bits (147), Expect = 7e-09
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 1745 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1804
Query: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 1805 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1845
>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
isoform 4 [Homo sapiens]
Length = 2332
Score = 2976 bits (7716), Expect = 0.0
Identities = 1474/1474 (100%), Positives = 1474/1474 (100%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
Score = 108 bits (269), Expect = 5e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 1265 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1321
Query: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1442 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1501
Query: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 1502 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557
Score = 107 bits (266), Expect = 1e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 1610 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1669
Query: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 1670 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1729
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 1730 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1789
Query: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 1790 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1849
Query: 963 LVEGFQAEEISKREDA 978
L++ + +E+A
Sbjct: 1850 LMKHLEESNKEAKEEA 1865
Score = 103 bits (256), Expect = 2e-21
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
SRFRLL H + T D + +I LN +T+AME + P + L + NYIFT +F+
Sbjct: 1598 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1655
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
E K+VA FG + + + WN LD +VL+S++ I + + + + + ++R++
Sbjct: 1656 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1711
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
R+LR R L+++ A G++ +++T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1712 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1765
Score = 68.2 bits (165), Expect = 6e-11
Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 41/248 (16%)
Query: 3 EEEDGAGAEESG-----QPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALA 57
EEE+ EE + R + L+D+ +G SA SEA+ PY
Sbjct: 1548 EEEEARRREEKRLRRLEKKRRNLMLDDVIASGSS----------ASAASEAQCKPY---- 1593
Query: 58 PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
S SR R + + + VI LN VT+ M + D L
Sbjct: 1594 ------YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA----L 1643
Query: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
+ + F +E V K+VA FG + + D WN+LD IV+ ++ +L+ V+ S
Sbjct: 1644 KICNYIFTVIFVLESVFKLVA---FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1700
Query: 178 A---------VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 228
+R +R+ R L+ + MR L+ ++ LP +GN+ LL +FFIF +
Sbjct: 1701 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1760
Query: 229 GVQLWAGL 236
GV+L+ L
Sbjct: 1761 GVELFGDL 1768
Score = 61.2 bits (147), Expect = 7e-09
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822
Query: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1863
>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
isoform 8 [Homo sapiens]
Length = 2284
Score = 2976 bits (7716), Expect = 0.0
Identities = 1474/1474 (100%), Positives = 1474/1474 (100%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
Score = 108 bits (269), Expect = 5e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 1265 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1321
Query: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1442 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1501
Query: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 1502 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557
Score = 107 bits (266), Expect = 1e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 1610 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1669
Query: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 1670 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1729
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 1730 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1789
Query: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 1790 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1849
Query: 963 LVEGFQAEEISKREDA 978
L++ + +E+A
Sbjct: 1850 LMKHLEESNKEAKEEA 1865
Score = 103 bits (256), Expect = 2e-21
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
SRFRLL H + T D + +I LN +T+AME + P + L + NYIFT +F+
Sbjct: 1598 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1655
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
E K+VA FG + + + WN LD +VL+S++ I + + + + + ++R++
Sbjct: 1656 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1711
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
R+LR R L+++ A G++ +++T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1712 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1765
Score = 68.2 bits (165), Expect = 6e-11
Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 41/248 (16%)
Query: 3 EEEDGAGAEESG-----QPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALA 57
EEE+ EE + R + L+D+ +G SA SEA+ PY
Sbjct: 1548 EEEEARRREEKRLRRLEKKRRNLMLDDVIASGSS----------ASAASEAQCKPY---- 1593
Query: 58 PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
S SR R + + + VI LN VT+ M + D L
Sbjct: 1594 ------YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA----L 1643
Query: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
+ + F +E V K+VA FG + + D WN+LD IV+ ++ +L+ V+ S
Sbjct: 1644 KICNYIFTVIFVLESVFKLVA---FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1700
Query: 178 A---------VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 228
+R +R+ R L+ + MR L+ ++ LP +GN+ LL +FFIF +
Sbjct: 1701 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1760
Query: 229 GVQLWAGL 236
GV+L+ L
Sbjct: 1761 GVELFGDL 1768
Score = 61.2 bits (147), Expect = 7e-09
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822
Query: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1863
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 2976 bits (7716), Expect = 0.0
Identities = 1474/1474 (100%), Positives = 1474/1474 (100%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
Score = 108 bits (269), Expect = 5e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 1265 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1321
Query: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1442 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1501
Query: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 1502 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557
Score = 107 bits (266), Expect = 1e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 1599 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1658
Query: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 1659 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1718
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 1719 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1778
Query: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 1779 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1838
Query: 963 LVEGFQAEEISKREDA 978
L++ + +E+A
Sbjct: 1839 LMKHLEESNKEAKEEA 1854
Score = 103 bits (256), Expect = 2e-21
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
SRFRLL H + T D + +I LN +T+AME + P + L + NYIFT +F+
Sbjct: 1587 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1644
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
E K+VA FG + + + WN LD +VL+S++ I + + + + + ++R++
Sbjct: 1645 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1700
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
R+LR R L+++ A G++ +++T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1701 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1754
Score = 66.6 bits (161), Expect = 2e-10
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)
Query: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
VI LN VT+ M + D L+ + F +E V K+VA FG + +
Sbjct: 1609 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1661
Query: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
D WN+LD IV+ ++ +L+ V+ S +R +R+ R L+ + MR L
Sbjct: 1662 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1721
Query: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
+ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1722 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1757
Score = 61.2 bits (147), Expect = 7e-09
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 1752 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1811
Query: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 1812 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1852
>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
isoform 9 [Homo sapiens]
Length = 2273
Score = 2976 bits (7716), Expect = 0.0
Identities = 1474/1474 (100%), Positives = 1474/1474 (100%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
Score = 108 bits (269), Expect = 5e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 1265 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1321
Query: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1442 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1501
Query: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 1502 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557
Score = 107 bits (266), Expect = 1e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 1599 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1658
Query: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 1659 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1718
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 1719 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1778
Query: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 1779 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1838
Query: 963 LVEGFQAEEISKREDA 978
L++ + +E+A
Sbjct: 1839 LMKHLEESNKEAKEEA 1854
Score = 103 bits (256), Expect = 2e-21
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
SRFRLL H + T D + +I LN +T+AME + P + L + NYIFT +F+
Sbjct: 1587 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1644
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
E K+VA FG + + + WN LD +VL+S++ I + + + + + ++R++
Sbjct: 1645 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1700
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
R+LR R L+++ A G++ +++T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1701 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1754
Score = 66.6 bits (161), Expect = 2e-10
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)
Query: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
VI LN VT+ M + D L+ + F +E V K+VA FG + +
Sbjct: 1609 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1661
Query: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
D WN+LD IV+ ++ +L+ V+ S +R +R+ R L+ + MR L
Sbjct: 1662 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1721
Query: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
+ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1722 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1757
Score = 61.2 bits (147), Expect = 7e-09
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 1752 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1811
Query: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 1812 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1852
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 2919 bits (7567), Expect = 0.0
Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451
Score = 108 bits (269), Expect = 5e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298
Query: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
Query: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534
Score = 107 bits (266), Expect = 1e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 1576 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1635
Query: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 1636 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1695
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 1696 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1755
Query: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 1756 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1815
Query: 963 LVEGFQAEEISKREDA 978
L++ + +E+A
Sbjct: 1816 LMKHLEESNKEAKEEA 1831
Score = 103 bits (256), Expect = 2e-21
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
SRFRLL H + T D + +I LN +T+AME + P + L + NYIFT +F+
Sbjct: 1564 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1621
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
E K+VA FG + + + WN LD +VL+S++ I + + + + + ++R++
Sbjct: 1622 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1677
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
R+LR R L+++ A G++ +++T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1678 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731
Score = 66.6 bits (161), Expect = 2e-10
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)
Query: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
VI LN VT+ M + D L+ + F +E V K+VA FG + +
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1638
Query: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
D WN+LD IV+ ++ +L+ V+ S +R +R+ R L+ + MR L
Sbjct: 1639 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1698
Query: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
+ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1699 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734
Score = 61.2 bits (147), Expect = 7e-09
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788
Query: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829
>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
isoform 13 [Homo sapiens]
Length = 2243
Score = 2919 bits (7567), Expect = 0.0
Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451
Score = 108 bits (269), Expect = 5e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298
Query: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
Query: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534
Score = 107 bits (266), Expect = 1e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 1569 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1628
Query: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 1629 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1688
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 1689 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1748
Query: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 1749 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1808
Query: 963 LVEGFQAEEISKREDA 978
L++ + +E+A
Sbjct: 1809 LMKHLEESNKEAKEEA 1824
Score = 105 bits (261), Expect = 4e-22
Identities = 67/212 (31%), Positives = 118/212 (55%), Gaps = 15/212 (7%)
Query: 1225 DDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLV 1284
++E + +R+R + R A C + +S Y SRFRLL H + T D +
Sbjct: 1526 EEEARRREEKRLRRLEKKRRKAQC--KPYYSDY-----SRFRLLVHHLCTSHYLDLFITG 1578
Query: 1285 IIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRS 1344
+I LN +T+AME + P + L + NYIFT +F+ E K+VA FG + + +
Sbjct: 1579 VIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFVLESVFKLVA----FGFRRFFQD 1632
Query: 1345 SWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLLRTLRPLRVISRAQGLKLVV 1402
WN LD +VL+S++ I + + + + + ++R++R+LR R L+++ A G++ ++
Sbjct: 1633 RWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALL 1692
Query: 1403 ETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
+T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1693 DTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1724
Score = 66.6 bits (161), Expect = 2e-10
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)
Query: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
VI LN VT+ M + D L+ + F +E V K+VA FG + +
Sbjct: 1579 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1631
Query: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
D WN+LD IV+ ++ +L+ V+ S +R +R+ R L+ + MR L
Sbjct: 1632 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1691
Query: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
+ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1692 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1727
Score = 61.2 bits (147), Expect = 7e-09
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 1722 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1781
Query: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 1782 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1822
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 2919 bits (7567), Expect = 0.0
Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451
Score = 108 bits (269), Expect = 5e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298
Query: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
Query: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534
Score = 107 bits (266), Expect = 1e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 1576 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1635
Query: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 1636 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1695
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 1696 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1755
Query: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 1756 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1815
Query: 963 LVEGFQAEEISKREDA 978
L++ + +E+A
Sbjct: 1816 LMKHLEESNKEAKEEA 1831
Score = 103 bits (256), Expect = 2e-21
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
SRFRLL H + T D + +I LN +T+AME + P + L + NYIFT +F+
Sbjct: 1564 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1621
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
E K+VA FG + + + WN LD +VL+S++ I + + + + + ++R++
Sbjct: 1622 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1677
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
R+LR R L+++ A G++ +++T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1678 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731
Score = 66.6 bits (161), Expect = 2e-10
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)
Query: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
VI LN VT+ M + D L+ + F +E V K+VA FG + +
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1638
Query: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
D WN+LD IV+ ++ +L+ V+ S +R +R+ R L+ + MR L
Sbjct: 1639 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1698
Query: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
+ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1699 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734
Score = 61.2 bits (147), Expect = 7e-09
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788
Query: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829
>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
isoform 6 [Homo sapiens]
Length = 2306
Score = 2919 bits (7567), Expect = 0.0
Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451
Score = 108 bits (269), Expect = 5e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298
Query: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
Query: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534
Score = 107 bits (266), Expect = 1e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 1587 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1646
Query: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 1647 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1706
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 1707 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1766
Query: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 1767 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1826
Query: 963 LVEGFQAEEISKREDA 978
L++ + +E+A
Sbjct: 1827 LMKHLEESNKEAKEEA 1842
Score = 103 bits (256), Expect = 2e-21
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
SRFRLL H + T D + +I LN +T+AME + P + L + NYIFT +F+
Sbjct: 1575 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1632
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
E K+VA FG + + + WN LD +VL+S++ I + + + + + ++R++
Sbjct: 1633 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1688
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
R+LR R L+++ A G++ +++T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1689 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742
Score = 68.2 bits (165), Expect = 6e-11
Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 41/248 (16%)
Query: 3 EEEDGAGAEESG-----QPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALA 57
EEE+ EE + R + L+D+ +G SA SEA+ PY
Sbjct: 1525 EEEEARRREEKRLRRLEKKRRNLMLDDVIASGSS----------ASAASEAQCKPY---- 1570
Query: 58 PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
S SR R + + + VI LN VT+ M + D L
Sbjct: 1571 ------YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA----L 1620
Query: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
+ + F +E V K+VA FG + + D WN+LD IV+ ++ +L+ V+ S
Sbjct: 1621 KICNYIFTVIFVLESVFKLVA---FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1677
Query: 178 A---------VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 228
+R +R+ R L+ + MR L+ ++ LP +GN+ LL +FFIF +
Sbjct: 1678 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1737
Query: 229 GVQLWAGL 236
GV+L+ L
Sbjct: 1738 GVELFGDL 1745
Score = 61.2 bits (147), Expect = 7e-09
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799
Query: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1840
>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
isoform 11 [Homo sapiens]
Length = 2261
Score = 2919 bits (7567), Expect = 0.0
Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451
Score = 108 bits (269), Expect = 5e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298
Query: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
Query: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534
Score = 107 bits (266), Expect = 1e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 1587 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1646
Query: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 1647 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1706
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 1707 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1766
Query: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 1767 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1826
Query: 963 LVEGFQAEEISKREDA 978
L++ + +E+A
Sbjct: 1827 LMKHLEESNKEAKEEA 1842
Score = 103 bits (256), Expect = 2e-21
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
SRFRLL H + T D + +I LN +T+AME + P + L + NYIFT +F+
Sbjct: 1575 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1632
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
E K+VA FG + + + WN LD +VL+S++ I + + + + + ++R++
Sbjct: 1633 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1688
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
R+LR R L+++ A G++ +++T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1689 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742
Score = 68.2 bits (165), Expect = 6e-11
Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 41/248 (16%)
Query: 3 EEEDGAGAEESG-----QPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALA 57
EEE+ EE + R + L+D+ +G SA SEA+ PY
Sbjct: 1525 EEEEARRREEKRLRRLEKKRRNLMLDDVIASGSS----------ASAASEAQCKPY---- 1570
Query: 58 PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
S SR R + + + VI LN VT+ M + D L
Sbjct: 1571 ------YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA----L 1620
Query: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
+ + F +E V K+VA FG + + D WN+LD IV+ ++ +L+ V+ S
Sbjct: 1621 KICNYIFTVIFVLESVFKLVA---FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1677
Query: 178 A---------VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 228
+R +R+ R L+ + MR L+ ++ LP +GN+ LL +FFIF +
Sbjct: 1678 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1737
Query: 229 GVQLWAGL 236
GV+L+ L
Sbjct: 1738 GVELFGDL 1745
Score = 61.2 bits (147), Expect = 7e-09
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799
Query: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1840
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 2919 bits (7567), Expect = 0.0
Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451
Score = 108 bits (269), Expect = 5e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298
Query: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
Query: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534
Score = 107 bits (266), Expect = 1e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 1576 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1635
Query: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 1636 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1695
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 1696 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1755
Query: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 1756 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1815
Query: 963 LVEGFQAEEISKREDA 978
L++ + +E+A
Sbjct: 1816 LMKHLEESNKEAKEEA 1831
Score = 103 bits (256), Expect = 2e-21
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
SRFRLL H + T D + +I LN +T+AME + P + L + NYIFT +F+
Sbjct: 1564 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1621
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
E K+VA FG + + + WN LD +VL+S++ I + + + + + ++R++
Sbjct: 1622 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1677
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
R+LR R L+++ A G++ +++T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1678 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731
Score = 66.6 bits (161), Expect = 2e-10
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)
Query: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
VI LN VT+ M + D L+ + F +E V K+VA FG + +
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1638
Query: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
D WN+LD IV+ ++ +L+ V+ S +R +R+ R L+ + MR L
Sbjct: 1639 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1698
Query: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
+ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1699 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734
Score = 61.2 bits (147), Expect = 7e-09
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788
Query: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829
>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
isoform 2 [Homo sapiens]
Length = 2354
Score = 2919 bits (7567), Expect = 0.0
Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451
Score = 108 bits (269), Expect = 5e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298
Query: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
Query: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534
Score = 107 bits (266), Expect = 1e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 1587 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1646
Query: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 1647 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1706
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 1707 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1766
Query: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 1767 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1826
Query: 963 LVEGFQAEEISKREDA 978
L++ + +E+A
Sbjct: 1827 LMKHLEESNKEAKEEA 1842
Score = 103 bits (256), Expect = 2e-21
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
SRFRLL H + T D + +I LN +T+AME + P + L + NYIFT +F+
Sbjct: 1575 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1632
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
E K+VA FG + + + WN LD +VL+S++ I + + + + + ++R++
Sbjct: 1633 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1688
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
R+LR R L+++ A G++ +++T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1689 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742
Score = 68.2 bits (165), Expect = 6e-11
Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 41/248 (16%)
Query: 3 EEEDGAGAEESG-----QPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALA 57
EEE+ EE + R + L+D+ +G SA SEA+ PY
Sbjct: 1525 EEEEARRREEKRLRRLEKKRRNLMLDDVIASGSS----------ASAASEAQCKPY---- 1570
Query: 58 PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
S SR R + + + VI LN VT+ M + D L
Sbjct: 1571 ------YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA----L 1620
Query: 118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
+ + F +E V K+VA FG + + D WN+LD IV+ ++ +L+ V+ S
Sbjct: 1621 KICNYIFTVIFVLESVFKLVA---FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1677
Query: 178 A---------VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 228
+R +R+ R L+ + MR L+ ++ LP +GN+ LL +FFIF +
Sbjct: 1678 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1737
Query: 229 GVQLWAGL 236
GV+L+ L
Sbjct: 1738 GVELFGDL 1745
Score = 61.2 bits (147), Expect = 7e-09
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799
Query: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1840
>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
isoform 14 [Homo sapiens]
Length = 2171
Score = 2919 bits (7567), Expect = 0.0
Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)
Query: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1 MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
Query: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121 DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
Query: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
Query: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421 STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
Query: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481 SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
Query: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541 ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
Query: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601 TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
Query: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661 ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
Query: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721 EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
Query: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781 VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
Query: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841 VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
Query: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901 PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
Query: 961 AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
AILVEGFQAE GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961 AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057
Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117
Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177
Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451
Score = 108 bits (269), Expect = 5e-23
Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
+RL+C +I+ K F +++ I +N +++ +E + P L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298
Query: 787 ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
EM +K++ +G Y+++ +N+ DG++V+ISV +I V G G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
R +R L+++ L+ + LM ++ + ++ F IF ILG+ LF KF
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
+ DT + + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478
Query: 937 --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + + + N+ V ++VE F + EE +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534
Score = 107 bits (266), Expect = 1e-22
Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)
Query: 742 SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
S Y I I +N ++M +E+++QP+ L AL+I N +FT +F LE + KL+ +G
Sbjct: 1576 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1635
Query: 802 YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
+ ++ +N D IV++S+ I ++ + ++R R+ RVLKL++ +
Sbjct: 1636 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1695
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
+ L +M+ + V +L ML FIF+ LG+ LFG E + L F +
Sbjct: 1696 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1755
Query: 911 WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
A +T+F++ T ++WN ++ + + + +YF++ + +VL N+++A+
Sbjct: 1756 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1815
Query: 963 LVEGFQAEEISKREDA 978
L++ + +E+A
Sbjct: 1816 LMKHLEESNKEAKEEA 1831
Score = 103 bits (256), Expect = 2e-21
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
SRFRLL H + T D + +I LN +T+AME + P + L + NYIFT +F+
Sbjct: 1564 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1621
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
E K+VA FG + + + WN LD +VL+S++ I + + + + + ++R++
Sbjct: 1622 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1677
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
R+LR R L+++ A G++ +++T+M +L +GN+ ++ F IF LGV+LF
Sbjct: 1678 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731
Score = 66.6 bits (161), Expect = 2e-10
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)
Query: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
VI LN VT+ M + D L+ + F +E V K+VA FG + +
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1638
Query: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
D WN+LD IV+ ++ +L+ V+ S +R +R+ R L+ + MR L
Sbjct: 1639 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1698
Query: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
+ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1699 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734
Score = 61.2 bits (147), Expect = 7e-09
Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C+ + + NFDN+G A +++F + + +GWVDIMY +DA H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ +FF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
+ + + E +P +G F N G A++ +F+V T + W IM + + Y
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788
Query: 371 NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
N IYF+ ++ F ++N+ + V+ E+ + +
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 1612 bits (4174), Expect = 0.0
Identities = 897/1524 (58%), Positives = 1029/1524 (67%), Gaps = 114/1524 (7%)
Query: 7 GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66
GA E G P G P +AE+ E + +PYPALA VFF L Q
Sbjct: 27 GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
Query: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
+RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 86 TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
Query: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD NVS SA+RTVRVLR
Sbjct: 146 FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246
PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL
Sbjct: 206 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
Query: 247 FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305
F ++ R YYQTE +E+PFICS R+NGM+ C +P G PC L +EAY
Sbjct: 266 FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
Query: 306 NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
++ C+NWNQYY C +G+ NP GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 323 TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
Query: 359 IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418
IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 383 IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
Query: 419 NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478
N STLASFSEPGSCYEELLKY+ +I RK RR ++ R P+ + GQ P
Sbjct: 443 NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
Query: 479 SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536
R+ R SVHHLV HHHHHHHHHYH +G+ R P P D +R +
Sbjct: 501 GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
Query: 537 PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592
P +P G P AESVHS YHADCH+E + +A + + A+ G G + YPT
Sbjct: 556 PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
Query: 593 V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642
+ TSP P+ K GP +L S P PY + ++ G
Sbjct: 616 ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
Query: 643 ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696
+S PC A + C SCPYC RA E EL+ E DSD VYEF
Sbjct: 671 QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
Query: 697 TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740
TQD +H D DP RR + EP + W R+IV
Sbjct: 731 TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
Query: 741 DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800
DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL GP
Sbjct: 791 DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
Query: 801 GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860
GYI+NPYNIFDG+IVVISVWEIVGQ GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 851 GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
Query: 861 TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919
TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 911 TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
Query: 920 LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979
LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAE
Sbjct: 971 LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE--------- 1021
Query: 980 GQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDR---------KKCLALVSLGEHPE 1030
GDAN+S+++ D S + D + K C V+ H E
Sbjct: 1022 --------------GDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLE 1067
Query: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090
R SL PPLI+ TAATPM PKS+ P SRR SSS P + K P S R
Sbjct: 1068 GRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLR 1125
Query: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1150
SSP +PW + +W+SRRSS +SLGRAPSLKRR GER SLLSGEG+ S D+E
Sbjct: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAA 1185
Query: 1151 ASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLAR 1210
P + R SL+ LP T + +D +G+ +
Sbjct: 1186 PGPRATPLRRAESLDPRPLRPAALPPT-----------------KCRDRDGQVVALPSDF 1228
Query: 1211 ALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCH 1270
LR D D + DD+ S R+ + P C R++W+ Y+F PQ+RFR+ C
Sbjct: 1229 FLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ 1288
Query: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330
++ITHKMFDHVVLV IFLNC+TIA+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVV
Sbjct: 1289 KVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348
Query: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390
ALG GE AYL+SSWN+LDGLLVL+S++DI+V+M S G KILG+LRVLRLLRTLRPLR
Sbjct: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408
Query: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450
VISRA GLKLVVETL+SSL+PIGNIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+
Sbjct: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468
Query: 1451 NKSDCAEASYRWVRHKYNFDNLGQ 1474
K+ C A YRWVR KYNFDNLGQ
Sbjct: 1469 TKAQCRAAHYRWVRRKYNFDNLGQ 1492
Score = 119 bits (298), Expect = 2e-26
Identities = 106/416 (25%), Positives = 188/416 (45%), Gaps = 42/416 (10%)
Query: 735 TFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKL 794
+ + S Y I I VN ++M +E++ QP+ L AL+ N VFT +F E LKL
Sbjct: 1603 SIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKL 1662
Query: 795 LVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKL 844
+ +G + K+ +N D IV++S+ I ++ + ++R R+ RVLKL
Sbjct: 1663 VAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKL 1722
Query: 845 VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG-DTLPDR 903
++ ++ L +++ + V +L ML FI++ LG+ LFG SE + + L
Sbjct: 1723 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRH 1782
Query: 904 KNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTS-----------SWAALYFIALMTFGN 952
F + A +T+F++ T ++WN ++ + + S + + +YF+ +
Sbjct: 1783 ATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQ 1842
Query: 953 YVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDG 1012
+VL N++VA+L++ + REDA I+L + G A + +++ G
Sbjct: 1843 FVLVNVVVAVLMKHLEESNKEAREDAELDAE-IELEMAQGPGSARRVDADRPPLPQESPG 1901
Query: 1013 DGDRKKCLA-------LVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPA 1065
D +A ++SL + + ++P H P+ + + G G LG
Sbjct: 1902 ARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPH--PRPLQEVEMETYGAGTPLG-- 1957
Query: 1066 SRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKR 1121
S + S AE A+ ++ P A SSP A S S R+PSL R
Sbjct: 1958 SVASVHSPPAESCASLQI---PLAVSSP-----ARSGEPLHALSPRGTARSPSLSR 2005
Score = 114 bits (284), Expect = 1e-24
Identities = 76/288 (26%), Positives = 148/288 (51%), Gaps = 47/288 (16%)
Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA--LEISNIVFTSLFALEMLLKL 794
+K++ K F +++ I +N +++ +E + T L +SN +FT++F EM++K+
Sbjct: 1288 QKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKV 1347
Query: 795 ----LVYGPFGYIKNPYNIFDGVIVVISVWEIV---GQQGGG--LSVLRTFRLMRVLKLV 845
L+ G Y+++ +N+ DG++V++S+ +IV GG L VLR RL+R L+ +
Sbjct: 1348 VALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPL 1407
Query: 846 RFL---PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT--- 899
R + P L+ + L+ ++ + ++ F IF ILG+ LF KF DT
Sbjct: 1408 RVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNI 1467
Query: 900 -------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST---------- 936
+ + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1468 STKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNH 1527
Query: 937 SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + ++ + N+ V ++VE F +AEE +RE+
Sbjct: 1528 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1575
Score = 90.5 bits (223), Expect = 1e-17
Identities = 53/167 (31%), Positives = 95/167 (56%), Gaps = 8/167 (4%)
Query: 1270 HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKV 1329
H + T D + II +N IT++ME P S + L NY+FT VF+ E +K+
Sbjct: 1605 HSLCTSHYLDLFITFIICVNVITMSMEHYN-QPKSLDEA-LKYCNYVFTIVFVFEAALKL 1662
Query: 1330 VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLLRTLR 1387
VA FG + + + WN LD +VL+S++ I + + S + ++R++R+LR R
Sbjct: 1663 VA----FGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIAR 1718
Query: 1388 PLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
L+++ A G++ +++T++ +L +GN+ ++ F I+ LGV+LF
Sbjct: 1719 VLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1765
Score = 64.3 bits (155), Expect = 9e-10
Identities = 46/183 (25%), Positives = 87/183 (47%), Gaps = 23/183 (12%)
Query: 67 DSRPRSWCLRTVCNP-WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF 125
D P + ++C + + +I +N +T+ M + + D + +++F
Sbjct: 1596 DYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEAL-----KYCNYVF 1650
Query: 126 AF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSA------ 178
F E +K+VA FG + + D WN+LD IV+ ++ + L+ + SA
Sbjct: 1651 TIVFVFEAALKLVA---FGFRRFFKDRWNQLDLAIVLLSLM--GITLEEIEMSAALPINP 1705
Query: 179 -----VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
+R +R+ R L+ + MR L+ ++ LP +GN+ LL +FFI+ +GV+L+
Sbjct: 1706 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1765
Query: 234 AGL 236
L
Sbjct: 1766 GRL 1768
Score = 60.5 bits (145), Expect = 1e-08
Identities = 33/109 (30%), Positives = 61/109 (55%), Gaps = 14/109 (12%)
Query: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNF 372
C A + + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 1473 CRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWML 1532
Query: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1533 LYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1581
Score = 38.5 bits (88), Expect = 0.051
Identities = 23/100 (23%), Positives = 43/100 (43%), Gaps = 14/100 (14%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM------DAHS 368
+ + E NP +G F N G A++ +F+V T + W IM + D H
Sbjct: 1763 ELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHC 1822
Query: 369 FYNF-----IYFILLIIVGSFFMINLCLVVIATQFSETKQ 403
+YF+ ++V F ++N+ + V+ E+ +
Sbjct: 1823 LSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNK 1862
>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform a [Homo sapiens]
Length = 2353
Score = 1612 bits (4174), Expect = 0.0
Identities = 897/1524 (58%), Positives = 1029/1524 (67%), Gaps = 114/1524 (7%)
Query: 7 GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66
GA E G P G P +AE+ E + +PYPALA VFF L Q
Sbjct: 27 GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
Query: 67 DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
+RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 86 TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
Query: 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD NVS SA+RTVRVLR
Sbjct: 146 FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246
PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL
Sbjct: 206 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
Query: 247 FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305
F ++ R YYQTE +E+PFICS R+NGM+ C +P G PC L +EAY
Sbjct: 266 FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
Query: 306 NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
++ C+NWNQYY C +G+ NP GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 323 TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
Query: 359 IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418
IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 383 IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
Query: 419 NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478
N STLASFSEPGSCYEELLKY+ +I RK RR ++ R P+ + GQ P
Sbjct: 443 NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
Query: 479 SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536
R+ R SVHHLV HHHHHHHHHYH +G+ R P P D +R +
Sbjct: 501 GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
Query: 537 PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592
P +P G P AESVHS YHADCH+E + +A + + A+ G G + YPT
Sbjct: 556 PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
Query: 593 V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642
+ TSP P+ K GP +L S P PY + ++ G
Sbjct: 616 ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
Query: 643 ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696
+S PC A + C SCPYC RA E EL+ E DSD VYEF
Sbjct: 671 QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
Query: 697 TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740
TQD +H D DP RR + EP + W R+IV
Sbjct: 731 TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
Query: 741 DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800
DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL GP
Sbjct: 791 DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
Query: 801 GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860
GYI+NPYNIFDG+IVVISVWEIVGQ GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 851 GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
Query: 861 TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919
TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 911 TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
Query: 920 LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979
LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAE
Sbjct: 971 LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE--------- 1021
Query: 980 GQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDR---------KKCLALVSLGEHPE 1030
GDAN+S+++ D S + D + K C V+ H E
Sbjct: 1022 --------------GDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLE 1067
Query: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090
R SL PPLI+ TAATPM PKS+ P SRR SSS P + K P S R
Sbjct: 1068 GRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLR 1125
Query: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1150
SSP +PW + +W+SRRSS +SLGRAPSLKRR GER SLLSGEG+ S D+E
Sbjct: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAA 1185
Query: 1151 ASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLAR 1210
P + R SL+ LP T + +D +G+ +
Sbjct: 1186 PGPRATPLRRAESLDPRPLRPAALPPT-----------------KCRDRDGQVVALPSDF 1228
Query: 1211 ALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCH 1270
LR D D + DD+ S R+ + P C R++W+ Y+F PQ+RFR+ C
Sbjct: 1229 FLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ 1288
Query: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330
++ITHKMFDHVVLV IFLNC+TIA+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVV
Sbjct: 1289 KVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348
Query: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390
ALG GE AYL+SSWN+LDGLLVL+S++DI+V+M S G KILG+LRVLRLLRTLRPLR
Sbjct: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408
Query: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450
VISRA GLKLVVETL+SSL+PIGNIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+
Sbjct: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468
Query: 1451 NKSDCAEASYRWVRHKYNFDNLGQ 1474
K+ C A YRWVR KYNFDNLGQ
Sbjct: 1469 TKAQCRAAHYRWVRRKYNFDNLGQ 1492
Score = 122 bits (306), Expect = 3e-27
Identities = 113/442 (25%), Positives = 199/442 (45%), Gaps = 44/442 (9%)
Query: 711 RRQRSL--GPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQP 768
RR+RS P+A+ A + + + S Y I I VN ++M +E++ QP
Sbjct: 1583 RRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQP 1642
Query: 769 EELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ-- 826
+ L AL+ N VFT +F E LKL+ +G + K+ +N D IV++S+ I ++
Sbjct: 1643 KSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIE 1702
Query: 827 --------GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 878
+ ++R R+ RVLKL++ ++ L +++ + V +L ML FI
Sbjct: 1703 MSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFI 1762
Query: 879 FSILGMHLFGCKFASERDG-DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTS 937
++ LG+ LFG SE + + L F + A +T+F++ T ++WN ++ + + S
Sbjct: 1763 YAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECS 1822
Query: 938 -----------SWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQ 986
+ + +YF+ + +VL N++VA+L++ + REDA I+
Sbjct: 1823 REDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAE-IE 1881
Query: 987 LPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLA-------LVSLGEHPELRKSLLPPL 1039
L + G A + +++ G D +A ++SL + + ++P
Sbjct: 1882 LEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPAS 1941
Query: 1040 IIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSA 1099
H P+ + + G G LG S + S AE A+ ++ P A SSP A
Sbjct: 1942 APH--PRPLQEVEMETYGAGTPLG--SVASVHSPPAESCASLQI---PLAVSSP-----A 1989
Query: 1100 ASSWTSRRSSRNSLGRAPSLKR 1121
S S R+PSL R
Sbjct: 1990 RSGEPLHALSPRGTARSPSLSR 2011
Score = 114 bits (284), Expect = 1e-24
Identities = 76/288 (26%), Positives = 148/288 (51%), Gaps = 47/288 (16%)
Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA--LEISNIVFTSLFALEMLLKL 794
+K++ K F +++ I +N +++ +E + T L +SN +FT++F EM++K+
Sbjct: 1288 QKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKV 1347
Query: 795 ----LVYGPFGYIKNPYNIFDGVIVVISVWEIV---GQQGGG--LSVLRTFRLMRVLKLV 845
L+ G Y+++ +N+ DG++V++S+ +IV GG L VLR RL+R L+ +
Sbjct: 1348 VALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPL 1407
Query: 846 RFL---PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT--- 899
R + P L+ + L+ ++ + ++ F IF ILG+ LF KF DT
Sbjct: 1408 RVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNI 1467
Query: 900 -------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST---------- 936
+ + NFD+L A++++F + +++ W ++Y+G+ +
Sbjct: 1468 STKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNH 1527
Query: 937 SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ W LYFI+ + ++ + N+ V ++VE F +AEE +RE+
Sbjct: 1528 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1575
Score = 92.0 bits (227), Expect = 4e-18
Identities = 64/211 (30%), Positives = 112/211 (53%), Gaps = 15/211 (7%)
Query: 1226 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1285
+E L + ER R R+ P+ +R + A P + LC T D + I
Sbjct: 1574 EEKRLRRLERRR---RSTFPSPEAQRRPYYADYSPTRRSIHSLC----TSHYLDLFITFI 1626
Query: 1286 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1345
I +N IT++ME P S + L NY+FT VF+ E +K+VA FG + + +
Sbjct: 1627 ICVNVITMSMEHYN-QPKSLDEA-LKYCNYVFTIVFVFEAALKLVA----FGFRRFFKDR 1680
Query: 1346 WNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLLRTLRPLRVISRAQGLKLVVE 1403
WN LD +VL+S++ I + + S + ++R++R+LR R L+++ A G++ +++
Sbjct: 1681 WNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLD 1740
Query: 1404 TLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
T++ +L +GN+ ++ F I+ LGV+LF
Sbjct: 1741 TVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771
Score = 64.3 bits (155), Expect = 9e-10
Identities = 46/183 (25%), Positives = 87/183 (47%), Gaps = 23/183 (12%)
Query: 67 DSRPRSWCLRTVCNP-WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF 125
D P + ++C + + +I +N +T+ M + + D + +++F
Sbjct: 1602 DYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEAL-----KYCNYVF 1656
Query: 126 AF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSA------ 178
F E +K+VA FG + + D WN+LD IV+ ++ + L+ + SA
Sbjct: 1657 TIVFVFEAALKLVA---FGFRRFFKDRWNQLDLAIVLLSLM--GITLEEIEMSAALPINP 1711
Query: 179 -----VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
+R +R+ R L+ + MR L+ ++ LP +GN+ LL +FFI+ +GV+L+
Sbjct: 1712 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771
Query: 234 AGL 236
L
Sbjct: 1772 GRL 1774
Score = 60.5 bits (145), Expect = 1e-08
Identities = 33/109 (30%), Positives = 61/109 (55%), Gaps = 14/109 (12%)
Query: 323 CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNF 372
C A + + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 1473 CRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWML 1532
Query: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1533 LYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1581
Score = 38.5 bits (88), Expect = 0.051
Identities = 23/100 (23%), Positives = 43/100 (43%), Gaps = 14/100 (14%)
Query: 318 QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM------DAHS 368
+ + E NP +G F N G A++ +F+V T + W IM + D H
Sbjct: 1769 ELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHC 1828
Query: 369 FYNF-----IYFILLIIVGSFFMINLCLVVIATQFSETKQ 403
+YF+ ++V F ++N+ + V+ E+ +
Sbjct: 1829 LSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNK 1868
>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform b [Homo sapiens]
Length = 2188
Score = 818 bits (2114), Expect = 0.0
Identities = 478/872 (54%), Positives = 567/872 (65%), Gaps = 108/872 (12%)
Query: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
A P SCP C +G G + + +E S S A E +A R
Sbjct: 512 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
Query: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 569 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
Query: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 629 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
Query: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 689 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
Query: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 749 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
Query: 946 ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005
ALMTFGNYVLFNLLVAILVEGFQAE GDAN+S S+ D
Sbjct: 809 ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 845
Query: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055
S + LD GD K C ++ H L P SLP
Sbjct: 846 SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 888
Query: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102
G A GPA R + SS + +++ +S S+RSS + PW +++
Sbjct: 889 LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 948
Query: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158
W SRRSS NSL K + PS E SLLS E G ++ E +++E RA+P + H
Sbjct: 949 WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1002
Query: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202
HR +L + + S DL + + G H A+ R G A H+DCNG+
Sbjct: 1003 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1062
Query: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262
S + D G+D ++E + + RVR I P C R+ WS Y+F P+
Sbjct: 1063 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1121
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
+RFR+LC II HK+FD+VVL IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+
Sbjct: 1122 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1181
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382
EMT+KVV+LG FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S G KILG+LRVLRL
Sbjct: 1182 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1241
Query: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442
LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C
Sbjct: 1242 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1301
Query: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
G DTRNITN+SDC A+YRWV HKYNFDNLGQ
Sbjct: 1302 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQ 1333
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
Query: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
Query: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
Query: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
Query: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
Query: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
Query: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
Query: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Y+ +ILRKA RR + +A R L AP
Sbjct: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Score = 119 bits (298), Expect = 2e-26
Identities = 80/313 (25%), Positives = 151/313 (48%), Gaps = 25/313 (7%)
Query: 691 EAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDT---FRKIVDSKYFGR 747
E ++ Q + + R +R R L + L ++ C T + S Y
Sbjct: 1397 ENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDI 1456
Query: 748 GIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPY 807
I I +N ++M +E++ QP L AL+ N +FT++F LE +LKL+ +G + K+ +
Sbjct: 1457 FITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRW 1516
Query: 808 NIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPALQRQLVV 857
N D IV++SV I ++ + ++R R+ RVLKL++ ++ L
Sbjct: 1517 NQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDT 1576
Query: 858 LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-ERDGDTLPDRKNFDSLLWAIVTV 916
+++ + V +L ML FI++ LG+ LFG + E + + F++ A +T+
Sbjct: 1577 VVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTL 1636
Query: 917 FQILTQEDWNKVLYNG-----------MASTSSWAALYFIALMTFGNYVLFNLLVAILVE 965
FQ+ T ++WN ++ + ++S + LYF++ + +VL N++VA+L++
Sbjct: 1637 FQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMK 1696
Query: 966 GFQAEEISKREDA 978
+EDA
Sbjct: 1697 HLDDSNKEAQEDA 1709
Score = 114 bits (285), Expect = 7e-25
Identities = 81/296 (27%), Positives = 148/296 (50%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA--LEISNIVFTSLF 786
+R++C T I+ K F ++ I +N +++ +E + T L +SN +FT++F
Sbjct: 1124 FRVLCQT---IIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIF 1180
Query: 787 ALEMLLKL----LVYGPFGYIKNPYNIFDGVIVVISVWEIV---GQQGGG--LSVLRTFR 837
EM LK+ L +G Y+++ +N+ DG +V +S+ +IV GG L VLR R
Sbjct: 1181 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1240
Query: 838 LMRVLKLVRFL---PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
L+R L+ +R + P L+ + L+ ++ + ++ F IF ILG+ LF KF
Sbjct: 1241 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1300
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM----- 933
DT + + NFD+L A++++F + +++ W ++YNG+
Sbjct: 1301 LGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAV 1360
Query: 934 -----ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ + W LYFI+ + ++ + N+ V ++VE F +AEE +RE+
Sbjct: 1361 DQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1416
Score = 112 bits (279), Expect = 4e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
Query: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
Query: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
Query: 233 WAG 235
+ G
Sbjct: 1293 FKG 1295
Score = 103 bits (257), Expect = 1e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
Query: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
Query: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 96.7 bits (239), Expect = 2e-19
Identities = 61/182 (33%), Positives = 104/182 (57%), Gaps = 10/182 (5%)
Query: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
RLL H + T D + II LN +T+++E P S E L NY+FT VF+ E
Sbjct: 1442 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYN-QPTSLETA-LKYCNYMFTTVFVLEA 1499
Query: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLL 1383
+K+VA FG + + + WN LD +VL+SV+ I + + + + ++R++R+L
Sbjct: 1500 VLKLVA----FGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVL 1555
Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQG 1443
R R L+++ A G++ +++T++ +L +GN+ ++ F I+ LGV+LF GK VC
Sbjct: 1556 RIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GK-LVCND 1613
Query: 1444 ED 1445
E+
Sbjct: 1614 EN 1615
Score = 71.2 bits (173), Expect = 7e-12
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
+G E SG S ++ G G R A + G + E E V+
Sbjct: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
Query: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
Query: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
Query: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
Score = 65.5 bits (158), Expect = 4e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
Query: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
Query: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
Score = 62.0 bits (149), Expect = 4e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
Query: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 60.5 bits (145), Expect = 1e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
Score = 50.4 bits (119), Expect = 1e-05
Identities = 23/72 (31%), Positives = 44/72 (61%), Gaps = 2/72 (2%)
Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
Query: 965 EGFQAEEISKRE 976
F E +RE
Sbjct: 399 TQF--SETKQRE 408
Score = 46.6 bits (109), Expect = 2e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
Query: 396 TQF 398
F
Sbjct: 828 EGF 830
Score = 38.1 bits (87), Expect = 0.067
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
Query: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform a [Homo sapiens]
Length = 2223
Score = 818 bits (2114), Expect = 0.0
Identities = 478/872 (54%), Positives = 567/872 (65%), Gaps = 108/872 (12%)
Query: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
A P SCP C +G G + + +E S S A E +A R
Sbjct: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
Query: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
Query: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
Query: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
Query: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
Query: 946 ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005
ALMTFGNYVLFNLLVAILVEGFQAE GDAN+S S+ D
Sbjct: 844 ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 880
Query: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055
S + LD GD K C ++ H L P SLP
Sbjct: 881 SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 923
Query: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102
G A GPA R + SS + +++ +S S+RSS + PW +++
Sbjct: 924 LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 983
Query: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158
W SRRSS NSL K + PS E SLLS E G ++ E +++E RA+P + H
Sbjct: 984 WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1037
Query: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202
HR +L + + S DL + + G H A+ R G A H+DCNG+
Sbjct: 1038 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1097
Query: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262
S + D G+D ++E + + RVR I P C R+ WS Y+F P+
Sbjct: 1098 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1156
Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
+RFR+LC II HK+FD+VVL IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+
Sbjct: 1157 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1216
Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382
EMT+KVV+LG FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S G KILG+LRVLRL
Sbjct: 1217 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1276
Query: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442
LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C
Sbjct: 1277 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1336
Query: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
G DTRNITN+SDC A+YRWV HKYNFDNLGQ
Sbjct: 1337 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQ 1368
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
Query: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
Query: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
Query: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
Query: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
Query: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
Query: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
Query: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Y+ +ILRKA RR + +A R L AP
Sbjct: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Score = 119 bits (298), Expect = 2e-26
Identities = 80/313 (25%), Positives = 151/313 (48%), Gaps = 25/313 (7%)
Query: 691 EAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDT---FRKIVDSKYFGR 747
E ++ Q + + R +R R L + L ++ C T + S Y
Sbjct: 1432 ENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDI 1491
Query: 748 GIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPY 807
I I +N ++M +E++ QP L AL+ N +FT++F LE +LKL+ +G + K+ +
Sbjct: 1492 FITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRW 1551
Query: 808 NIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPALQRQLVV 857
N D IV++SV I ++ + ++R R+ RVLKL++ ++ L
Sbjct: 1552 NQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDT 1611
Query: 858 LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-ERDGDTLPDRKNFDSLLWAIVTV 916
+++ + V +L ML FI++ LG+ LFG + E + + F++ A +T+
Sbjct: 1612 VVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTL 1671
Query: 917 FQILTQEDWNKVLYNG-----------MASTSSWAALYFIALMTFGNYVLFNLLVAILVE 965
FQ+ T ++WN ++ + ++S + LYF++ + +VL N++VA+L++
Sbjct: 1672 FQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMK 1731
Query: 966 GFQAEEISKREDA 978
+EDA
Sbjct: 1732 HLDDSNKEAQEDA 1744
Score = 114 bits (285), Expect = 7e-25
Identities = 81/296 (27%), Positives = 148/296 (50%), Gaps = 50/296 (16%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA--LEISNIVFTSLF 786
+R++C T I+ K F ++ I +N +++ +E + T L +SN +FT++F
Sbjct: 1159 FRVLCQT---IIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIF 1215
Query: 787 ALEMLLKL----LVYGPFGYIKNPYNIFDGVIVVISVWEIV---GQQGGG--LSVLRTFR 837
EM LK+ L +G Y+++ +N+ DG +V +S+ +IV GG L VLR R
Sbjct: 1216 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1275
Query: 838 LMRVLKLVRFL---PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
L+R L+ +R + P L+ + L+ ++ + ++ F IF ILG+ LF KF
Sbjct: 1276 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1335
Query: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM----- 933
DT + + NFD+L A++++F + +++ W ++YNG+
Sbjct: 1336 LGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAV 1395
Query: 934 -----ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
+ + W LYFI+ + ++ + N+ V ++VE F +AEE +RE+
Sbjct: 1396 DQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1451
Score = 112 bits (279), Expect = 4e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
Query: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
Query: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
Query: 233 WAG 235
+ G
Sbjct: 1328 FKG 1330
Score = 103 bits (257), Expect = 1e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
Query: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
Query: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
Score = 96.7 bits (239), Expect = 2e-19
Identities = 61/182 (33%), Positives = 104/182 (57%), Gaps = 10/182 (5%)
Query: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
RLL H + T D + II LN +T+++E P S E L NY+FT VF+ E
Sbjct: 1477 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYN-QPTSLETA-LKYCNYMFTTVFVLEA 1534
Query: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLL 1383
+K+VA FG + + + WN LD +VL+SV+ I + + + + ++R++R+L
Sbjct: 1535 VLKLVA----FGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVL 1590
Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQG 1443
R R L+++ A G++ +++T++ +L +GN+ ++ F I+ LGV+LF GK VC
Sbjct: 1591 RIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GK-LVCND 1648
Query: 1444 ED 1445
E+
Sbjct: 1649 EN 1650
Score = 71.2 bits (173), Expect = 7e-12
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
+G E SG S ++ G G R A + G + E E V+
Sbjct: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
Query: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
Query: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
Query: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
Score = 65.5 bits (158), Expect = 4e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
Query: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
Query: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
Score = 62.0 bits (149), Expect = 4e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
Query: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
Score = 60.5 bits (145), Expect = 1e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
Query: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
Score = 52.4 bits (124), Expect = 3e-06
Identities = 70/279 (25%), Positives = 111/279 (39%), Gaps = 35/279 (12%)
Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
Query: 965 EGF----QAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
F Q E E LS + ++ GD E + L RK
Sbjct: 399 TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDC--YEEIFQYVCHIL-----RKAKR 451
Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAAT-PMSLPKSTSTGLGEALGPASRRTSS------SG 1073
+ L + + R+ L P A P + G + G R S G
Sbjct: 452 RALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHG 511
Query: 1074 SAEPGAAHE------MKSPPSARSSPHS-----PWSAASSWTSRRSSRNSLGRAPSLKRR 1122
A PG H SP A +PH+ P + AS S ++ GR PS
Sbjct: 512 PASPGNDHSGRELCPQHSPLDA--TPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGS 569
Query: 1123 SPSGER----RSLLSGEGQESQDEEESSEEERASPAGSD 1157
+ SG+ S GE + D SSE+ +S G +
Sbjct: 570 TDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKE 608
Score = 46.6 bits (109), Expect = 2e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
Query: 396 TQF 398
F
Sbjct: 863 EGF 865
Score = 38.1 bits (87), Expect = 0.067
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
Query: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
sapiens]
Length = 2016
Score = 268 bits (684), Expect = 4e-71
Identities = 216/761 (28%), Positives = 352/761 (46%), Gaps = 73/761 (9%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
Query: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
G+ P ATP S P + E + P + T +PG +
Sbjct: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
P P + A S T NSLG S + QESQ
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
E S S S E EA +S D Q A G G E G +
Sbjct: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
A L P L D D E ++G R P C ++ ++
Sbjct: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
EM +K VA +G + Y ++W LD L+V +S++ ++ + + G +G ++ LR L
Sbjct: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1305
Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
R LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1306 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1365
Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLG 1473
+G+ N T NKS C + W + K NFDN+G
Sbjct: 1366 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVG 1406
Score = 144 bits (362), Expect = 9e-34
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
Query: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
C LPL
Sbjct: 1363 CINQTEGDLPL------------------------------------------------- 1373
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
Query: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Query: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
M E++ ++ + L S L KY +I
Sbjct: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
Score = 118 bits (296), Expect = 4e-26
Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
E +VK++A G +L D WN LDF ++I +DL NVS A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
+ I+ + ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
+ + S P +++ S L CG NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
Score = 115 bits (287), Expect = 4e-25
Identities = 175/829 (21%), Positives = 318/829 (38%), Gaps = 201/829 (24%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
Query: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRL---MRVLKLVRFLP 849
G F ++++P+N D VI++ E V G +S LRTFR+ ++ + ++ L
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
Query: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
Query: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
++ L ++L + + D T P+ +FDS
Sbjct: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
Query: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
+ +Q A E E F + +K+ AL G
Sbjct: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
G S L R + + PP +++ +G G
Sbjct: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
R RA + LE S + PP R+ + ++
Sbjct: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDT 1446
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDS 873
Score = 92.8 bits (229), Expect = 2e-18
Identities = 77/319 (24%), Positives = 146/319 (45%), Gaps = 52/319 (16%)
Query: 704 DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
D++DP RR D + +WRL T IV+ +F I+ IL++
Sbjct: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218
Query: 757 TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
+ ++ E Y E+ + + LE ++ +FT +F LEMLLK + YG Y N + D +I
Sbjct: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278
Query: 815 VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
V +S+ +V + G + LRT R +R L+ + ++ + L+ + ++
Sbjct: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338
Query: 870 MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
++ ++F IFSI+G++LF KF ++ +GD T+ + K
Sbjct: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398
Query: 905 --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSWAA-----LYFIALMTFGN 952
NFD++ + + Q+ T + W ++Y G W +YF+ + FG+
Sbjct: 1399 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458
Query: 953 YVLFNLLVAILVEGFQAEE 971
+ NL + ++++ F ++
Sbjct: 1459 FFTLNLFIGVIIDNFNQQK 1477
Score = 90.9 bits (224), Expect = 9e-18
Identities = 53/180 (29%), Positives = 88/180 (48%), Gaps = 17/180 (9%)
Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
FTA++ E VK++A G+C +LR WN LD +++++ V LG
Sbjct: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
+ LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 215 VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Score = 85.9 bits (211), Expect = 3e-16
Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
Query: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
Query: 911 WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
+++ +FQI T W+ +L G + + L+F +
Sbjct: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
Query: 951 GNYVLFNLLVAILVEGFQAEEISKREDAS 979
++ N+ +AI++E F E S
Sbjct: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
Score = 82.0 bits (201), Expect = 4e-15
Identities = 53/175 (30%), Positives = 93/175 (53%), Gaps = 9/175 (5%)
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1319
P ++++ I+T + FD ++ +I LN +T+ +E D S E+I L N +F A
Sbjct: 1513 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET---DDQSPEKINILAKINLLFVA 1569
Query: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
+F E VK+ AL Y +SWN+ D ++V++S++ ++S + + RV
Sbjct: 1570 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1624
Query: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
+RL R R LR+I A+G++ ++ LM SL + NI ++ I+ I G+ F
Sbjct: 1625 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1679
Score = 62.8 bits (151), Expect = 3e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 61.6 bits (148), Expect = 6e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
Query: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
Query: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
Score = 32.7 bits (73), Expect = 2.8
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
>gi|150417969 voltage-gated sodium channel type V alpha isoform d
[Homo sapiens]
Length = 1998
Score = 268 bits (684), Expect = 4e-71
Identities = 216/761 (28%), Positives = 352/761 (46%), Gaps = 73/761 (9%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
Query: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
G+ P ATP S P + E + P + T +PG +
Sbjct: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
P P + A S T NSLG S + QESQ
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
E S S S E EA +S D Q A G G E G +
Sbjct: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
A L P L D D E ++G R P C ++ ++
Sbjct: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
EM +K VA +G + Y ++W LD L+V +S++ ++ + + G +G ++ LR L
Sbjct: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1305
Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
R LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1306 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1365
Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLG 1473
+G+ N T NKS C + W + K NFDN+G
Sbjct: 1366 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVG 1406
Score = 122 bits (305), Expect = 4e-27
Identities = 108/387 (27%), Positives = 170/387 (43%), Gaps = 88/387 (22%)
Query: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
Query: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
C LPL
Sbjct: 1363 CINQTEGDLPL------------------------------------------------- 1373
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLE-GWVDI 359
+Y N+ S +N GE K +NFDN+G ++A+ QV + W
Sbjct: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVYEEQPQW--- 1422
Query: 360 MYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRVRF 416
++ Y +IYF++ II GSFF +NL + VI F++ K++ + M E++ ++
Sbjct: 1423 ------EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY 1476
Query: 417 LSNASTLASFSEPGSCYEELLKYLVYI 443
+ L S L KY +I
Sbjct: 1477 YNAMKKLGSKKPQKPIPRPLNKYQGFI 1503
Score = 120 bits (301), Expect = 1e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
+ + S P +++ S L CG NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
Score = 114 bits (286), Expect = 6e-25
Identities = 176/829 (21%), Positives = 319/829 (38%), Gaps = 201/829 (24%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
Query: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
G F ++++P+N D VI++ V E + + G LS LRTF R ++ + ++ L
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
Query: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
Query: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
++ L ++L + + D T P+ +FDS
Sbjct: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
Query: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
+ +Q A E E F + +K+ AL G
Sbjct: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
G S L R + + PP +++ +G G
Sbjct: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
R RA + LE S + PP R+ + ++
Sbjct: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDT 1446
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDS 873
Score = 92.0 bits (227), Expect = 4e-18
Identities = 53/180 (29%), Positives = 89/180 (49%), Gaps = 17/180 (9%)
Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Score = 87.8 bits (216), Expect = 7e-17
Identities = 76/312 (24%), Positives = 146/312 (46%), Gaps = 56/312 (17%)
Query: 704 DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
D++DP RR D + +WRL T IV+ +F I+ IL++
Sbjct: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218
Query: 757 TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
+ ++ E Y E+ + + LE ++ +FT +F LEMLLK + YG Y N + D +I
Sbjct: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278
Query: 815 VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
V +S+ +V + G + LRT R +R L+ + ++ + L+ + ++
Sbjct: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338
Query: 870 MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
++ ++F IFSI+G++LF KF ++ +GD T+ + K
Sbjct: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398
Query: 905 --NFDSL---LWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLL 959
NFD++ A++ V++ Q ++N +Y +YF+ + FG++ NL
Sbjct: 1399 KVNFDNVGAGYLALLQVYEEQPQWEYNLYMY-----------IYFVIFIIFGSFFTLNLF 1447
Query: 960 VAILVEGFQAEE 971
+ ++++ F ++
Sbjct: 1448 IGVIIDNFNQQK 1459
Score = 85.9 bits (211), Expect = 3e-16
Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 1506 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1565
Query: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 1566 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1624
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 1625 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1680
Query: 911 WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
+++ +FQI T W+ +L G + + L+F +
Sbjct: 1681 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1740
Query: 951 GNYVLFNLLVAILVEGFQAEEISKREDAS 979
++ N+ +AI++E F E S
Sbjct: 1741 SFLIVVNMYIAIILENFSVATEESTEPLS 1769
Score = 82.0 bits (201), Expect = 4e-15
Identities = 53/175 (30%), Positives = 93/175 (53%), Gaps = 9/175 (5%)
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1319
P ++++ I+T + FD ++ +I LN +T+ +E D S E+I L N +F A
Sbjct: 1495 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET---DDQSPEKINILAKINLLFVA 1551
Query: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
+F E VK+ AL Y +SWN+ D ++V++S++ ++S + + RV
Sbjct: 1552 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1606
Query: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
+RL R R LR+I A+G++ ++ LM SL + NI ++ I+ I G+ F
Sbjct: 1607 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1661
Score = 62.8 bits (151), Expect = 3e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 61.6 bits (148), Expect = 6e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 1512 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1564
Query: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 1565 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1623
Query: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1624 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1662
Score = 32.7 bits (73), Expect = 2.8
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
>gi|150417967 voltage-gated sodium channel type V alpha isoform c
[Homo sapiens]
Length = 2016
Score = 268 bits (684), Expect = 4e-71
Identities = 216/761 (28%), Positives = 352/761 (46%), Gaps = 73/761 (9%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
Query: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
G+ P ATP S P + E + P + T +PG +
Sbjct: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
P P + A S T NSLG S + QESQ
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083
Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
E S S S E EA +S D Q A G G E G +
Sbjct: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141
Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
A L P L D D E ++G R P C ++ ++
Sbjct: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192
Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
EM +K VA +G + Y ++W LD L+V +S++ ++ + + G +G ++ LR L
Sbjct: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1305
Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
R LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1306 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1365
Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLG 1473
+G+ N T NKS C + W + K NFDN+G
Sbjct: 1366 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVG 1406
Score = 144 bits (362), Expect = 9e-34
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248
Query: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
C LPL
Sbjct: 1363 CINQTEGDLPL------------------------------------------------- 1373
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425
Query: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485
Query: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
M E++ ++ + L S L KY +I
Sbjct: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521
Score = 120 bits (301), Expect = 1e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
+ + S P +++ S L CG NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
Score = 114 bits (286), Expect = 6e-25
Identities = 176/829 (21%), Positives = 319/829 (38%), Gaps = 201/829 (24%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
Query: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
G F ++++P+N D VI++ V E + + G LS LRTF R ++ + ++ L
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
Query: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
Query: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
++ L ++L + + D T P+ +FDS
Sbjct: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
Query: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
+ +Q A E E F + +K+ AL G
Sbjct: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
G S L R + + PP +++ +G G
Sbjct: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
R RA + LE S + PP R+ + ++
Sbjct: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDT 1446
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDS 873
Score = 92.8 bits (229), Expect = 2e-18
Identities = 77/319 (24%), Positives = 146/319 (45%), Gaps = 52/319 (16%)
Query: 704 DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
D++DP RR D + +WRL T IV+ +F I+ IL++
Sbjct: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218
Query: 757 TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
+ ++ E Y E+ + + LE ++ +FT +F LEMLLK + YG Y N + D +I
Sbjct: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278
Query: 815 VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
V +S+ +V + G + LRT R +R L+ + ++ + L+ + ++
Sbjct: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338
Query: 870 MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
++ ++F IFSI+G++LF KF ++ +GD T+ + K
Sbjct: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398
Query: 905 --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSWAA-----LYFIALMTFGN 952
NFD++ + + Q+ T + W ++Y G W +YF+ + FG+
Sbjct: 1399 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458
Query: 953 YVLFNLLVAILVEGFQAEE 971
+ NL + ++++ F ++
Sbjct: 1459 FFTLNLFIGVIIDNFNQQK 1477
Score = 92.0 bits (227), Expect = 4e-18
Identities = 53/180 (29%), Positives = 89/180 (49%), Gaps = 17/180 (9%)
Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Score = 85.9 bits (211), Expect = 3e-16
Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583
Query: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698
Query: 911 WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
+++ +FQI T W+ +L G + + L+F +
Sbjct: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758
Query: 951 GNYVLFNLLVAILVEGFQAEEISKREDAS 979
++ N+ +AI++E F E S
Sbjct: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787
Score = 82.0 bits (201), Expect = 4e-15
Identities = 53/175 (30%), Positives = 93/175 (53%), Gaps = 9/175 (5%)
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1319
P ++++ I+T + FD ++ +I LN +T+ +E D S E+I L N +F A
Sbjct: 1513 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET---DDQSPEKINILAKINLLFVA 1569
Query: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
+F E VK+ AL Y +SWN+ D ++V++S++ ++S + + RV
Sbjct: 1570 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1624
Query: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
+RL R R LR+I A+G++ ++ LM SL + NI ++ I+ I G+ F
Sbjct: 1625 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1679
Score = 62.8 bits (151), Expect = 3e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 61.6 bits (148), Expect = 6e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582
Query: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641
Query: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680
Score = 32.7 bits (73), Expect = 2.8
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
>gi|237512980 voltage-gated sodium channel type V alpha isoform e
[Homo sapiens]
Length = 1983
Score = 266 bits (680), Expect = 1e-70
Identities = 215/761 (28%), Positives = 351/761 (46%), Gaps = 74/761 (9%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
Query: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
G+ P ATP S P + E + P + T +PG +
Sbjct: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
P P + A S T NSLG + QESQ
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSK---------------QESQPVS 1082
Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
E S S S E EA +S D Q A G G E G +
Sbjct: 1083 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1140
Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
A L P L D D E ++G R P C ++ ++
Sbjct: 1141 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1191
Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1251
Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
EM +K VA +G + Y ++W LD L+V +S++ ++ + + G +G ++ LR L
Sbjct: 1252 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1304
Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
R LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1305 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1364
Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLG 1473
+G+ N T NKS C + W + K NFDN+G
Sbjct: 1365 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVG 1405
Score = 144 bits (362), Expect = 9e-34
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1247
Query: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 1248 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1302
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 1303 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1361
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
C LPL
Sbjct: 1362 CINQTEGDLPL------------------------------------------------- 1372
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 1373 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1424
Query: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 1425 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1484
Query: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
M E++ ++ + L S L KY +I
Sbjct: 1485 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1520
Score = 120 bits (301), Expect = 1e-26
Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
E +VK++A G +L D WN LDF ++I + ++ L N+S A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
+ + S P +++ S L CG NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
Score = 114 bits (286), Expect = 6e-25
Identities = 176/829 (21%), Positives = 319/829 (38%), Gaps = 201/829 (24%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
Query: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
G F ++++P+N D VI++ V E + + G LS LRTF R ++ + ++ L
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237
Query: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
Query: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
++ L ++L + + D T P+ +FDS
Sbjct: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
Query: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
+ +Q A E E F + +K+ AL G
Sbjct: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
G S L R + + PP +++ +G G
Sbjct: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
R RA + LE S + PP R+ + ++
Sbjct: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDT 1446
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDS 873
Score = 92.8 bits (229), Expect = 2e-18
Identities = 77/319 (24%), Positives = 146/319 (45%), Gaps = 52/319 (16%)
Query: 704 DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
D++DP RR D + +WRL T IV+ +F I+ IL++
Sbjct: 1159 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1217
Query: 757 TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
+ ++ E Y E+ + + LE ++ +FT +F LEMLLK + YG Y N + D +I
Sbjct: 1218 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1277
Query: 815 VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
V +S+ +V + G + LRT R +R L+ + ++ + L+ + ++
Sbjct: 1278 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1337
Query: 870 MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
++ ++F IFSI+G++LF KF ++ +GD T+ + K
Sbjct: 1338 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1397
Query: 905 --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSWAA-----LYFIALMTFGN 952
NFD++ + + Q+ T + W ++Y G W +YF+ + FG+
Sbjct: 1398 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1457
Query: 953 YVLFNLLVAILVEGFQAEE 971
+ NL + ++++ F ++
Sbjct: 1458 FFTLNLFIGVIIDNFNQQK 1476
Score = 92.0 bits (227), Expect = 4e-18
Identities = 53/180 (29%), Positives = 89/180 (49%), Gaps = 17/180 (9%)
Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
FTA++ E VK++A G+C +LR WN LD +++++ + + LG
Sbjct: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214
Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
L LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 215 LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Score = 62.8 bits (151), Expect = 3e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 62.0 bits (149), Expect = 4e-09
Identities = 60/261 (22%), Positives = 107/261 (40%), Gaps = 49/261 (18%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM I +N ++M +E +Q E N L N++F ++F +L ++
Sbjct: 1523 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGTVLSDIIQK- 1581
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVL 858
Y +P +F V+R R+ R+L+L+R ++ L L
Sbjct: 1582 ---YFFSP-TLF--------------------RVIRLARIGRILRLIRGAKGIRTLLFAL 1617
Query: 859 MKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQ 918
M ++ + +LL L +FI+SI GM FA + + D NF + +++ +FQ
Sbjct: 1618 MMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFANSMLCLFQ 1673
Query: 919 ILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTFGNYVLFNL 958
I T W+ +L G + + L+F + ++ N+
Sbjct: 1674 ITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNM 1733
Query: 959 LVAILVEGFQAEEISKREDAS 979
+AI++E F E S
Sbjct: 1734 YIAIILENFSVATEESTEPLS 1754
Score = 46.6 bits (109), Expect = 2e-04
Identities = 43/175 (24%), Positives = 74/175 (42%), Gaps = 41/175 (23%)
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1319
P ++++ I+T + FD ++ +I LN +T+ +E D S E+I L N +F A
Sbjct: 1512 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET---DDQSPEKINILAKINLLFVA 1568
Query: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
+F + ++ Q Y S + RV
Sbjct: 1569 IFTGTVLSDII--------QKYFFSPT-----------------------------LFRV 1591
Query: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
+RL R R LR+I A+G++ ++ LM SL + NI ++ I+ I G+ F
Sbjct: 1592 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1646
Score = 41.2 bits (95), Expect = 0.008
Identities = 23/59 (38%), Positives = 33/59 (55%)
Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
F +R R+ R LR I +R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1589 FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1647
Score = 32.7 bits (73), Expect = 2.8
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
sapiens]
Length = 2015
Score = 266 bits (680), Expect = 1e-70
Identities = 215/761 (28%), Positives = 351/761 (46%), Gaps = 74/761 (9%)
Query: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
W I + +V + I + I++NTL M +E++ E L++ N+VFT +F
Sbjct: 703 WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
EM K++ P+ Y + +NIFD +IV++S+ E+ + LSVLR+FRL+RV KL +
Sbjct: 763 EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822
Query: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
P L + ++ ++ + ++L + +FIF+++GM LFG ++ RD D+ L R +
Sbjct: 823 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
A + +F+IL E W + +++ M S S L F+ +M GN V+ NL +A+L+
Sbjct: 883 DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941
Query: 967 FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
F A+ ++ D +++ +QL + Q G + DF L +K AL +
Sbjct: 942 FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998
Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
G+ P ATP S P + E + P + T +PG +
Sbjct: 999 GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037
Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
P P + A S T NSLG + QESQ
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSK---------------QESQPVS 1082
Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
E S S S E EA +S D Q A G G E G +
Sbjct: 1083 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1140
Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
A L P L D D E ++G R P C ++ ++
Sbjct: 1141 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1191
Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
R R C+ I+ H F+ ++ +I L+ +A E ++ ++ L ++ +FT VF+
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1251
Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
EM +K VA +G + Y ++W LD L+V +S++ ++ + + G +G ++ LR L
Sbjct: 1252 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1304
Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
R LRPLR +SR +G+++VV L+ ++ I N++++C F++IF I+GV LF GKF C
Sbjct: 1305 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1364
Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLG 1473
+G+ N T NKS C + W + K NFDN+G
Sbjct: 1365 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVG 1405
Score = 144 bits (362), Expect = 9e-34
Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)
Query: 69 RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
R R C V + WFE + +ILL+ L EDI + ++ ++L + D +F +
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1247
Query: 128 -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
F +EM++K VA +G K Y + W LDF IV ++ SL + F+ ++R
Sbjct: 1248 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1302
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
T+R LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG R
Sbjct: 1303 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1361
Query: 241 CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
C LPL
Sbjct: 1362 CINQTEGDLPL------------------------------------------------- 1372
Query: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
+Y N+ S +N GE K +NFDN+G ++A+ QV T +GW+DIM
Sbjct: 1373 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1424
Query: 361 YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
Y +D+ ++ Y +IYF++ II GSFF +NL + VI F++ K++ +
Sbjct: 1425 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1484
Query: 408 LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
M E++ ++ + L S L KY +I
Sbjct: 1485 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1520
Score = 118 bits (296), Expect = 4e-26
Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
R ++ + + F + M IL NCV + P + ++ F A +
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169
Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
E +VK++A G +L D WN LDF ++I +DL NVS A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
+ I+ + ++ +V L+ ++ L +V++L F +F ++G+QL+ G LR++C NF+
Sbjct: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285
Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
+ + S P +++ S L CG NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330
Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
TC + Y AGE NP G +FD+ +A++A+F+++T + W + + +
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386
Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
I+F+L+I +GSF+++NL L V+A + E Q E+ RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434
Score = 115 bits (287), Expect = 4e-25
Identities = 175/829 (21%), Positives = 318/829 (38%), Gaps = 201/829 (24%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
KI+ F IM IL N + M P T +E + FT+++ E L+K+L
Sbjct: 126 KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179
Query: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRL---MRVLKLVRFLP 849
G F ++++P+N D VI++ E V G +S LRTFR+ ++ + ++ L
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237
Query: 850 ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
+ L+ V++ T+ ++ F ++ L LF+
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297
Query: 877 -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
++ L ++L + + D T P+ +FDS
Sbjct: 298 GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357
Query: 909 LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
WA + +F+++TQ+ W ++ + S ++F+ ++ G++ L NL++A++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 969 AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
+ +Q A E E F + +K+ AL G
Sbjct: 418 EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454
Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
R SL + PL P++ + S R+ SSG+ E G KS
Sbjct: 455 TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497
Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
S P R + SL R S P R S+ + ++ E + ++
Sbjct: 498 ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545
Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
+E ++ S+ H L R + P T PG LH G + DCN
Sbjct: 546 DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598
Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
G S L R + + PP +++ +G G
Sbjct: 599 GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658
Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
R RA + LE S + PP R+ + ++
Sbjct: 659 RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718
Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
D + + I LN + +A+E + E L + N +FT +F AEMT K++AL +
Sbjct: 719 TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775
Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
Y + WN+ D ++V++S++++ +S +S+ L VLR R LR ++
Sbjct: 776 ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824
Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDT 1446
L +++ + +S+ +GN+ ++ IF ++G+QLF + + D+
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDS 873
Score = 92.8 bits (229), Expect = 2e-18
Identities = 77/319 (24%), Positives = 146/319 (45%), Gaps = 52/319 (16%)
Query: 704 DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
D++DP RR D + +WRL T IV+ +F I+ IL++
Sbjct: 1159 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1217
Query: 757 TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
+ ++ E Y E+ + + LE ++ +FT +F LEMLLK + YG Y N + D +I
Sbjct: 1218 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1277
Query: 815 VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
V +S+ +V + G + LRT R +R L+ + ++ + L+ + ++
Sbjct: 1278 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1337
Query: 870 MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
++ ++F IFSI+G++LF KF ++ +GD T+ + K
Sbjct: 1338 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1397
Query: 905 --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSWAA-----LYFIALMTFGN 952
NFD++ + + Q+ T + W ++Y G W +YF+ + FG+
Sbjct: 1398 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1457
Query: 953 YVLFNLLVAILVEGFQAEE 971
+ NL + ++++ F ++
Sbjct: 1458 FFTLNLFIGVIIDNFNQQK 1476
Score = 90.9 bits (224), Expect = 9e-18
Identities = 53/180 (29%), Positives = 88/180 (48%), Gaps = 17/180 (9%)
Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
Y+ P R +I+ H +F+ +++ I NC+ +A P E Y
Sbjct: 112 YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163
Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
FTA++ E VK++A G+C +LR WN LD +++++ V LG
Sbjct: 164 FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214
Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
+ LR R LR L+ IS GLK +V L+ S+K + +++V+ +F ++G+QLF G
Sbjct: 215 VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Score = 85.9 bits (211), Expect = 3e-16
Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV + F IM I +N ++M +E +Q E N L N++F ++F E ++KL
Sbjct: 1523 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1582
Query: 799 PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
+ Y N +NIFD V+V++S+ +I+ + ++ R RL R+ L+L+R
Sbjct: 1583 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1641
Query: 851 LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
++ L LM ++ + +LL L +FI+SI GM FA + + D NF +
Sbjct: 1642 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1697
Query: 911 WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
+++ +FQI T W+ +L G + + L+F +
Sbjct: 1698 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1757
Query: 951 GNYVLFNLLVAILVEGFQAEEISKREDAS 979
++ N+ +AI++E F E S
Sbjct: 1758 SFLIVVNMYIAIILENFSVATEESTEPLS 1786
Score = 82.0 bits (201), Expect = 4e-15
Identities = 53/175 (30%), Positives = 93/175 (53%), Gaps = 9/175 (5%)
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1319
P ++++ I+T + FD ++ +I LN +T+ +E D S E+I L N +F A
Sbjct: 1512 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET---DDQSPEKINILAKINLLFVA 1568
Query: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
+F E VK+ AL Y +SWN+ D ++V++S++ ++S + + RV
Sbjct: 1569 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1623
Query: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
+RL R R LR+I A+G++ ++ LM SL + NI ++ I+ I G+ F
Sbjct: 1624 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1678
Score = 62.8 bits (151), Expect = 3e-09
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V +P+ + + I+LN +F E S+ +LQ + F EM K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
AL + Y WN D IVI ++E L + + S +R+ R+LR + P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825
Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861
Score = 61.6 bits (148), Expect = 6e-09
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 83 FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
F+ M +I LN VT+ + E ++ IL + A F E +VK+ AL
Sbjct: 1529 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1581
Query: 143 GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
+ Y ++WN DF +VI ++ L +Q FS +R R+ R LR I
Sbjct: 1582 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1640
Query: 196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1641 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1679
Score = 32.7 bits (73), Expect = 2.8
Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
+A++ IF+++ E W++ M+ M+ + F+L++++G+ ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943
>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
subunit [Homo sapiens]
Length = 2339
Score = 175 bits (443), Expect = 3e-43
Identities = 144/525 (27%), Positives = 232/525 (44%), Gaps = 61/525 (11%)
Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLV 796
R++V ++ F ++ + +NTL + + ++ QP LT L + VF LF EM LK+
Sbjct: 476 RRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYG 535
Query: 797 YGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPAL 851
GP Y ++ +N FD ++V SV+E+V G+SVLR RL+R+ K+ ++ +L
Sbjct: 536 LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSL 595
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911
+ +V L+ +M ++ + LL LFI +F++LGM LFG +F + + T NFD+
Sbjct: 596 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPT----TNFDTFPA 651
Query: 912 AIVTVFQILTQEDWNKVLYNGM-----ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
AI+TVFQILT EDWN V+Y+G+ S +++ YFI L FGNY L N+ +AI V+
Sbjct: 652 AILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDN 711
Query: 967 F-QAEEISK----REDASGQ---------------LSCIQLPVDSQGGDANKSESEPDFF 1006
A+E++K E+A+ Q +S + + ++ ++ K+ S +
Sbjct: 712 LANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQR 771
Query: 1007 SPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPAS 1066
+ L R C AL S + E + + T + P G A GP
Sbjct: 772 ASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVG 831
Query: 1067 RRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSG 1126
+ + P + R +P A+ R + + P + P
Sbjct: 832 GKARPEAAEAPEGVDPPRRHHRHRDKDKTP---AAGDQDRAEAPKAESGEPGAREERPRP 888
Query: 1127 ERRSLLSGEGQESQDEEESSEEERASP---AGSDHRHRGSLEREAKSSFDLPDTLQVPGL 1183
R +E+ E+ E P G H RGS E A+ + P
Sbjct: 889 HR-----SHSKEAAGPPEARSERGRGPGPEGGRRHHRRGSPEEAAE---------REPRR 934
Query: 1184 HRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEG 1228
HR A HQD + + A + R R P G + G
Sbjct: 935 HR-------AHRHQDPSKECAGAKGERRARHRGGPRAGPREAESG 972
Score = 158 bits (400), Expect = 3e-38
Identities = 130/491 (26%), Positives = 207/491 (42%), Gaps = 106/491 (21%)
Query: 27 GAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVF----------------FYLSQDSRP 70
GAGG GPG PG + + A ++ F S+D+
Sbjct: 25 GAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVV 84
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDD---FIFAF 127
R + R P FE + + I+ NC+ L + E D + + + DD +
Sbjct: 85 RKYAKRITEWPPFEYMILATIIANCIVLAL----EQHLPDGDKTPMSERLDDTEPYFIGI 140
Query: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
F E +K++ALG +F K YL + WN +DF +V+ G+L + + +R VRVLR
Sbjct: 141 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGT--DFDLRTLRAVRVLR 198
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246
PL+ ++ +PS+++++ ++ + L + LL FF +F I+G++ + G CF
Sbjct: 199 PLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACF---- 254
Query: 247 FSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYN 306
P S D E G PCG + A
Sbjct: 255 ---PNSTDAEPV-----------------------------------GDFPCGKEAPARL 276
Query: 307 SSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMD- 365
+T C +Y+ P G NFDNI +A + +FQ IT+EGW DI+Y D
Sbjct: 277 CEGDTEC---REYWP-------GPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA 326
Query: 366 AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLAS 425
A + +N++YFI LII+GSFFM+NL L V++ +F++ ++R + N
Sbjct: 327 AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER------------VENRRAFLK 374
Query: 426 FSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSSSCSRS 485
EL YL +I + LA+ R A +E P R+
Sbjct: 375 LRRQQQIERELNGYLEWIFKAEEVMLAEEDRNA---------------EEKSPLDVLKRA 419
Query: 486 HRRLSVHHLVH 496
+ S + L+H
Sbjct: 420 ATKKSRNDLIH 430
Score = 139 bits (349), Expect = 3e-32
Identities = 129/467 (27%), Positives = 199/467 (42%), Gaps = 59/467 (12%)
Query: 1051 PKSTSTGLGEALGP-ASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSS 1109
P + G GP RR GS E A E + + R S A + R
Sbjct: 899 PPEARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARH 958
Query: 1110 RNSLGRAPSLKRRSPSGE---RRSLLSGEGQ--------ESQDEEESSEEERASPAGSDH 1158
R P R + SGE RR + Q E+ ++E + +E A +
Sbjct: 959 RGGPRAGP---REAESGEEPARRHRARHKAQPAHEAVEKETTEKEATEKEAEIVEADKEK 1015
Query: 1159 RHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDP- 1217
R RE + T+ V +H S E Q + + +P DP
Sbjct: 1016 ELRNHQPREPHCDLETSGTVTVGPMHTLPSTCLQKVEEQPEDADNQRNVTRMGSQPPDPN 1075
Query: 1218 -----------PLDGDDADDEGNL-----SKGER-------VRAWIRARLPACCLERDSW 1254
PL GN+ ++G++ +R+ R +P
Sbjct: 1076 TIVHIPVMLTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYS------- 1128
Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSN 1314
S + P + R CH I+T + F+ V+LV+I L+ I +A E P + S L +
Sbjct: 1129 SMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDP-VRTDSPRNNALKYLD 1187
Query: 1315 YIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL 1374
YIFT VF EM +K++ LG AY R WN+LD ++V +++ S S K +
Sbjct: 1188 YIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFS---GSKGKDI 1244
Query: 1375 GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
++ LR+LR LRPL+ I R LK V + +++SLK + NI+++ F IF ++ VQLF
Sbjct: 1245 NTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLF 1304
Query: 1435 KGKFFVCQGE------DTRN--ITNKSDCAEASYR-WVRHKYNFDNL 1472
KGKFF C E D R + + + EA R W ++ +++DN+
Sbjct: 1305 KGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNV 1351
Score = 114 bits (286), Expect = 6e-25
Identities = 69/239 (28%), Positives = 133/239 (55%), Gaps = 22/239 (9%)
Query: 749 IMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808
IM I +NT+ + +++++ P E L+ NIVFTS+F++E +LK++ +G Y ++ +N
Sbjct: 1477 IMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWN 1536
Query: 809 IFDGVIVVISVWEIVGQQGG------GLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
+FD V V+ S+ +I+ + LS LR FR R++KL+R ++ L +++
Sbjct: 1537 VFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSF 1596
Query: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDR-KNFDSLLWAIVTVFQILT 921
+ C+L+ + FI++I+GM +FG D DT +R NF + L A++ +F+ T
Sbjct: 1597 KALPYVCLLIAMLFFIYAIIGMQVFG---NIALDDDTSINRHNNFRTFLQALMLLFRSAT 1653
Query: 922 QEDWNKVLY------------NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
E W++++ N S +A YF++ + ++++ NL VA++++ F+
Sbjct: 1654 GEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFE 1712
Score = 104 bits (259), Expect = 8e-22
Identities = 95/405 (23%), Positives = 164/405 (40%), Gaps = 87/405 (21%)
Query: 44 ADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRP 103
AD P P + F LS + R +C V +FE + ++VI L+ + L P
Sbjct: 1113 ADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDP 1172
Query: 104 CEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIA 162
+ DS R L+ D F EMV+KM+ LG+ Y D WN LDF +V
Sbjct: 1173 ---VRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSG 1229
Query: 163 GMLEYSL------DLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
++ ++ D+ + ++R +RVLRPL+ I R+P ++ + ++++L + N+L+
Sbjct: 1230 ALVAFAFSGSKGKDINTIK--SLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILI 1287
Query: 217 LCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRE 276
+ FIF ++ VQL+ G F C+ +
Sbjct: 1288 VYMLFMFIFAVIAVQLFKGKF-------------------------------FYCTDESK 1316
Query: 277 NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAIN 336
R CR LDYE + W +Y +
Sbjct: 1317 ELERDCRGQ-------------YLDYEKEEVEAQPR--QWKKY--------------DFH 1347
Query: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSFFM 386
+DN+ +A + +F V T EGW ++ +DA + I++++ +V FF
Sbjct: 1348 YDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFF 1407
Query: 387 INLCLVVIATQFSETKQR---ESQLMREQR--VRFLSNASTLASF 426
+N+ + +I F E + E L + +R + F +A L +
Sbjct: 1408 VNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRY 1452
Score = 102 bits (254), Expect = 3e-21
Identities = 76/275 (27%), Positives = 129/275 (46%), Gaps = 42/275 (15%)
Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELT---NALEISNIVFTSLFALEMLLK 793
++I + F I+ I+ N + + +E H + T L+ + F +F E +K
Sbjct: 89 KRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIK 148
Query: 794 LLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLP 849
++ G Y++N +N+ D V+V+ + G L LR R++R LKLV +P
Sbjct: 149 IIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFD-LRTLRAVRVLRPLKLVSGIP 207
Query: 850 ALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCK-----FASERDGDTLPD-- 902
+LQ L +MK M + +LL I +F+I+G+ + K F + D + + D
Sbjct: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFP 267
Query: 903 --------------------------RKNFDSLLWAIVTVFQILTQEDWNKVLYN-GMAS 935
NFD++L+AI+TVFQ +T E W +LYN A+
Sbjct: 268 CGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAA 327
Query: 936 TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
++W LYFI L+ G++ + NL++ +L F E
Sbjct: 328 GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKE 362
Score = 97.4 bits (241), Expect = 9e-20
Identities = 141/629 (22%), Positives = 243/629 (38%), Gaps = 115/629 (18%)
Query: 424 ASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSSSCS 483
A EPG+ E + + A A+ R G P P GG+ S
Sbjct: 874 AESGEPGAREERPRPHRSHSKEAAGPPEARSERGRG--------PGPEGGRRHHRRGSPE 925
Query: 484 RSHRRLSVHHLVHHHHHHHHHYHLGNGTLRA-----PRASPEIQDRDANGSRRLMLPPPS 538
+ R H H H G RA PRA P + +RR +
Sbjct: 926 EAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPRAGPREAESGEEPARRHRARHKA 985
Query: 539 TPALSGAPPG-----GAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR-TVGSGKVYPT 592
PA E AD E Q P E SG TVG
Sbjct: 986 QPAHEAVEKETTEKEATEKEAEIVEADKEKELRNHQPREPHCDLETSGTVTVGP------ 1039
Query: 593 VHTSPPPETLKEKALVEVAASSGPPTLTSLNI-PPGPYSSMHKLLETQSTGACQSSCKIS 651
+HT P T +K + + +T + PP P + +H + TG + +
Sbjct: 1040 MHTLP--STCLQKVEEQPEDADNQRNVTRMGSQPPDPNTIVH--IPVMLTGPLGEATVVP 1095
Query: 652 SPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSR 711
S + +S A G EVE AD M V P+S
Sbjct: 1096 SGNVDLESQA-----------EGKKEVE-ADDVMRSGPRPIV--------------PYSS 1129
Query: 712 RQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE- 770
P+++L R C IV +YF I++ I ++++++ E + +
Sbjct: 1130 MFC-----LSPTNLL---RRFC---HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSP 1178
Query: 771 LTNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIV--VISVWEIVG 824
NAL+ + +FT +F EM++K++ G P Y ++ +NI D ++V + + G
Sbjct: 1179 RNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSG 1238
Query: 825 QQGGGLSVLRTFRLMRVL---KLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSI 881
+G ++ +++ R++RVL K ++ LP L+ ++ ++ NV ++ MLF+FIF++
Sbjct: 1239 SKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAV 1298
Query: 882 LGMHLFGCKF--------ASERD--GDTLPDRK---------------NFDSLLWAIVTV 916
+ + LF KF ERD G L K ++D++LWA++T+
Sbjct: 1299 IAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTL 1358
Query: 917 FQILTQEDWNKVLYNGMAST----------SSWAALYFIALMTFGNYVLFNLLVAILVEG 966
F + T E W VL + + +T +++++ + N+ VA+++
Sbjct: 1359 FTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIIT 1418
Query: 967 FQAEEISKREDAS---GQLSCIQLPVDSQ 992
FQ + + S + +CI + ++
Sbjct: 1419 FQEQGDKVMSECSLEKNERACIDFAISAK 1447
Score = 95.5 bits (236), Expect = 4e-19
Identities = 57/187 (30%), Positives = 106/187 (56%), Gaps = 14/187 (7%)
Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHS---AERIFLT 1311
S ++F + R RI F++++L I NCI +A+E+ D +ER+ T
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 1312 LSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGT 1371
+I +F E +K++ALG+ F + +YLR+ WNV+D ++VL ++ + +GT
Sbjct: 134 EPYFI--GIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGIL-------ATAGT 184
Query: 1372 KILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGV 1431
LR LR +R LRPL+++S L++V++++M ++ P+ I ++ ++F I+G+
Sbjct: 185 DF--DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGL 242
Query: 1432 QLFKGKF 1438
+ + GKF
Sbjct: 243 EFYMGKF 249
Score = 87.8 bits (216), Expect = 7e-17
Identities = 55/186 (29%), Positives = 105/186 (56%), Gaps = 13/186 (6%)
Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTL-- 1312
S+Y + FR R++ + F VVL ++ LN + +AM + + R+ TL
Sbjct: 461 SSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAM----VHYNQPRRLTTTLYF 516
Query: 1313 SNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTK 1372
+ ++F +FL EM++K+ LG ++Y RSS+N D +++ SV +++ + + +
Sbjct: 517 AEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSF 572
Query: 1373 ILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQ 1432
+ +LR LRLLR + + S L+ +V +L++S+K I +++ + F ++F +LG+Q
Sbjct: 573 GISVLRALRLLRIFKVTKYWS---SLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQ 629
Query: 1433 LFKGKF 1438
LF G+F
Sbjct: 630 LFGGQF 635
Score = 84.0 bits (206), Expect = 1e-15
Identities = 61/216 (28%), Positives = 109/216 (50%), Gaps = 19/216 (8%)
Query: 1221 GDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSR--FRLLCHRIITHKMF 1278
GD E +L K ER A I + A L R + PQ+R F+ + F
Sbjct: 1423 GDKVMSECSLEKNER--ACIDFAISAKPLTR-------YMPQNRQSFQYKTWTFVVSPPF 1473
Query: 1279 DHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGE 1338
++ ++ +I LN + + M+ D + L N +FT++F E +K++A FG
Sbjct: 1474 EYFIMAMIALNTVVLMMKF--YDAPYEYELMLKCLNIVFTSMFSMECVLKIIA----FGV 1527
Query: 1339 QAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGL 1398
Y R +WNV D + VL S+ DILV+ ++++ I L LRL R R ++++ + +
Sbjct: 1528 LNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFI--NLSFLRLFRAARLIKLLRQGYTI 1585
Query: 1399 KLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
++++ T + S K + + ++ F I+ I+G+Q+F
Sbjct: 1586 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1621
Score = 58.9 bits (141), Expect = 4e-08
Identities = 45/176 (25%), Positives = 86/176 (48%), Gaps = 14/176 (7%)
Query: 66 QDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF 125
Q + ++W V +P FE M +I LN V L M + + +L+ +
Sbjct: 1458 QSFQYKTWTF--VVSPPFEYFIMAMIALNTVVLMM----KFYDAPYEYELMLKCLNIVFT 1511
Query: 126 AFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQN-VSFSAVR 180
+ F++E V+K++A G+ Y D WN DF V+ + + + + N ++ S +R
Sbjct: 1512 SMFSMECVLKIIAFGVLN---YFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLR 1568
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
R R ++ + + ++RIL+ + + L V LL +FFI+ I+G+Q++ +
Sbjct: 1569 LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI 1624
Score = 54.3 bits (129), Expect = 9e-07
Identities = 45/179 (25%), Positives = 85/179 (47%), Gaps = 13/179 (7%)
Query: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
++ ++ R + R V F + + V+ LN + + M + +R F
Sbjct: 463 YFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQP-----RRLTTTLYFA 517
Query: 122 DFIF-AFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLE--YSLDLQNVSF-- 176
+F+F F EM +KM LG + Y ++N DF +++ + E ++ SF
Sbjct: 518 EFVFLGLFLTEMSLKMYGLG---PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGI 574
Query: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
S +R +R+LR + S+R LV LL+++ + ++L L F +F ++G+QL+ G
Sbjct: 575 SVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGG 633
Score = 41.6 bits (96), Expect = 0.006
Identities = 18/73 (24%), Positives = 39/73 (53%), Gaps = 5/73 (6%)
Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH-----SFYNFIYFILLIIVGSFFMINLC 390
NFD A + +FQ++T E W +MY +++ ++ YFI+L + G++ ++N+
Sbjct: 645 NFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVF 704
Query: 391 LVVIATQFSETKQ 403
L + + ++
Sbjct: 705 LAIAVDNLANAQE 717
Score = 34.3 bits (77), Expect = 0.96
Identities = 26/104 (25%), Positives = 44/104 (42%), Gaps = 13/104 (12%)
Query: 318 QYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM------------D 365
Q + N + + NF A + +F+ T E W +IM + +
Sbjct: 1619 QVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATE 1678
Query: 366 AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLM 409
S + + YF+ I + SF M+NL + VI F E R+S ++
Sbjct: 1679 CGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF-EYLTRDSSIL 1721
>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
subunit [Homo sapiens]
Length = 2270
Score = 175 bits (443), Expect = 3e-43
Identities = 115/319 (36%), Positives = 178/319 (55%), Gaps = 19/319 (5%)
Query: 673 AGAGEVELADRE-MPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFW-- 729
AG +E+ R + S +EA+ + D D+ + R+ A+ V F
Sbjct: 402 AGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHK 461
Query: 730 -RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
RL+ + R +V S+ F ++ + +NT + I +H QP+ LT+ L + +F LF L
Sbjct: 462 ERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLL 521
Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLK 843
EM LK+ GP Y + +N FD + V S++E+V G+SVLR RL+R+ K
Sbjct: 522 EMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFK 581
Query: 844 LVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDR 903
+ ++ +L+ +V LM +M ++ + LL LFI +F++LGM LFG +F + DG
Sbjct: 582 ITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-NFNDG---TPS 637
Query: 904 KNFDSLLWAIVTVFQILTQEDWNKVLYNGM-----ASTSSWAALYFIALMTFGNYVLFNL 958
NFD+ AI+TVFQILT EDWN+V+YNG+ S+ W+A+YFI L FGNY L N+
Sbjct: 638 ANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNV 697
Query: 959 LVAILVEGF-QAEEISKRE 976
+AI V+ A+E++K E
Sbjct: 698 FLAIAVDNLANAQELTKDE 716
Score = 145 bits (367), Expect = 2e-34
Identities = 106/365 (29%), Positives = 180/365 (49%), Gaps = 70/365 (19%)
Query: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFR--PCEDIACDSQRCRILQA 119
F +D+ R + + + P FE + + I+ NC+ L + + P +D S+R L+
Sbjct: 70 FIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRR---LEK 126
Query: 120 FDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN--VSF 176
+ + F E +K+VALG IF K YL + WN +DF +V++G+L + N V
Sbjct: 127 TEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDL 186
Query: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
+R VRVLRPL+ ++ +PS++I++ ++ + L + LL FF +F I+G++ ++G
Sbjct: 187 RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGK 246
Query: 237 LRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGP 296
L CF+ + L E P P G++ C
Sbjct: 247 LHRACFMNNSGIL--------------EGFDP-----PHPCGVQGC-------------- 273
Query: 297 PCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGW 356
P G + C +W P G FDNI +A + +FQ IT+EGW
Sbjct: 274 PAGYE-----------CKDW-----------IGPNDGITQFDNILFAVLTVFQCITMEGW 311
Query: 357 VDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRES------QLM 409
++Y DA + +N++YFI LII+GSFF++NL L V++ +F++ ++R +L
Sbjct: 312 TTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLR 371
Query: 410 REQRV 414
R+Q++
Sbjct: 372 RQQQI 376
Score = 127 bits (320), Expect = 6e-29
Identities = 72/228 (31%), Positives = 128/228 (56%), Gaps = 11/228 (4%)
Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSN 1314
S +IF + R CH I+ + F+ +L++I + I +A E P + ++ L +
Sbjct: 1132 SMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKV-LRYFD 1190
Query: 1315 YIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI-LVSMVSDSGTKI 1373
Y+FT VF EM +K++ G + +Y R WN+LD ++V+ +++ L + + + +
Sbjct: 1191 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1250
Query: 1374 LGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQL 1433
+ ++ LR+LR LRPL+ I R LK V + +++SLK + NI+++ F IF ++ VQL
Sbjct: 1251 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1310
Query: 1434 FKGKFFVC--QGEDTRN------ITNKSDCAEASYR-WVRHKYNFDNL 1472
FKGKFF C +DT + ++ + E R W RH++++DN+
Sbjct: 1311 FKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNI 1358
Score = 107 bits (267), Expect = 9e-23
Identities = 68/255 (26%), Positives = 130/255 (50%), Gaps = 28/255 (10%)
Query: 740 VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799
V S F IM I +NT+ + ++Y+ P AL+ NI FT +F+LE +LK++ +G
Sbjct: 1475 VVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGF 1534
Query: 800 FGYIKNPYNIFDGVIVVISVWEI-------VGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
Y ++ +NIFD + V+ S+ EI V G +S L+ FR R++KL+R ++
Sbjct: 1535 LNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIR 1594
Query: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWA 912
L +++ + C+L+ + FI++I+GM +FG E + NF S +
Sbjct: 1595 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEE--SHINRHNNFRSFFGS 1652
Query: 913 IVTVFQILTQEDWNKVLYNGMAST-------------------SSWAALYFIALMTFGNY 953
++ +F+ T E W +++ + + + A +YF++ + F ++
Sbjct: 1653 LMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSF 1712
Query: 954 VLFNLLVAILVEGFQ 968
++ NL VA++++ F+
Sbjct: 1713 LMLNLFVAVIMDNFE 1727
Score = 102 bits (253), Expect = 4e-21
Identities = 78/280 (27%), Positives = 128/280 (45%), Gaps = 51/280 (18%)
Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELT---NALEISNIVFTSLFALEMLLK 793
+K++D F I+ I+ N + + +E H ++ T LE + F +F E +K
Sbjct: 83 KKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142
Query: 794 LLVYGPF----GYIKNPYNIFDGVIVVISVWEIVGQQGG---GLSVLRTFRLMRVLKLVR 846
++ G Y++N +N+ D ++V+ + G L LR R++R LKLV
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVS 202
Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF------------------- 887
+P+LQ L +MK M + +LL I +F+I+G+ +
Sbjct: 203 GIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGF 262
Query: 888 ---------GCKFASE-------RDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYN 931
GC E DG T FD++L+A++TVFQ +T E W VLYN
Sbjct: 263 DPPHPCGVQGCPAGYECKDWIGPNDGIT-----QFDNILFAVLTVFQCITMEGWTTVLYN 317
Query: 932 -GMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
A ++W LYFI L+ G++ + NL++ +L F E
Sbjct: 318 TNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKE 357
Score = 96.3 bits (238), Expect = 2e-19
Identities = 58/185 (31%), Positives = 104/185 (56%), Gaps = 8/185 (4%)
Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER--PKIDPHSAERIFLTL 1312
S +IF + R ++I F++++L I NCI +A+E+ P+ D R
Sbjct: 68 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
Query: 1313 SNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTK 1372
Y F +F E +K+VALG+ F + +YLR+ WNV+D ++VL IL + + T
Sbjct: 128 EPY-FIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSG---ILATAGTHFNTH 183
Query: 1373 ILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQ 1432
+ LR LR +R LRPL+++S L++V++++M ++ P+ I ++ ++F I+G++
Sbjct: 184 V--DLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLE 241
Query: 1433 LFKGK 1437
+ GK
Sbjct: 242 FYSGK 246
Score = 87.4 bits (215), Expect = 1e-16
Identities = 71/306 (23%), Positives = 141/306 (46%), Gaps = 52/306 (16%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPE-ELTNALEISNIVFTSLFALEMLLKLLVY 797
IV+ +YF I++ I +++++ E E L + VFT +F EM++K++
Sbjct: 1149 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQ 1208
Query: 798 GPF----GYIKNPYNIFDGVIVV-----ISVWEIVGQQGGG----LSVLRTFRLMRVLKL 844
G Y ++ +NI D V+VV ++ +G G + LR R++R LK
Sbjct: 1209 GLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKT 1268
Query: 845 VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERD---- 896
++ LP L+ ++ ++ NV ++ LF+FIF+++ + LF KF S +D
Sbjct: 1269 IKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKE 1328
Query: 897 --GDTLPDRKN---------------FDSLLWAIVTVFQILTQEDWNKVLYNGM------ 933
G+ + KN +D+++WA++T+F + T E W +VL + +
Sbjct: 1329 CIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEED 1388
Query: 934 ----ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS---GQLSCIQ 986
S +++++ + N+ VA+++ FQ + E+ S + +CI
Sbjct: 1389 RGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACID 1448
Query: 987 LPVDSQ 992
+ ++
Sbjct: 1449 FAISAK 1454
Score = 85.9 bits (211), Expect = 3e-16
Identities = 56/193 (29%), Positives = 99/193 (51%), Gaps = 17/193 (8%)
Query: 55 ALAPVVFFYLSQDSRP-RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQR 113
A+ P ++ + P R C V +FE +LVI + + L P + +S+R
Sbjct: 1126 AMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDP---VLTNSER 1182
Query: 114 CRILQAFDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSL--- 169
++L+ FD F EMV+KM+ G I Y D WN LDF +V+ ++ ++L
Sbjct: 1183 NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANA 1242
Query: 170 -------DLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVF 222
D++ + ++R +RVLRPL+ I R+P ++ + ++ +L + N+L++
Sbjct: 1243 LGTNKGRDIKTIK--SLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFM 1300
Query: 223 FIFGIVGVQLWAG 235
FIF ++ VQL+ G
Sbjct: 1301 FIFAVIAVQLFKG 1313
Score = 73.9 bits (180), Expect = 1e-12
Identities = 59/219 (26%), Positives = 110/219 (50%), Gaps = 24/219 (10%)
Query: 1221 GDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSR--FRLLCHRIITHKMF 1278
GD +E +L K ER A I + A L R + PQ+R F+ + F
Sbjct: 1430 GDKMMEECSLEKNER--ACIDFAISAKPLTR-------YMPQNRHTFQYRVWHFVVSPSF 1480
Query: 1279 DHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGE 1338
++ ++ +I LN + + M+ P + E + L N FT VF E +KV+A FG
Sbjct: 1481 EYTIMAMIALNTVVLMMKYYSA-PCTYE-LALKYLNIAFTMVFSLECVLKVIA----FGF 1534
Query: 1339 QAYLRSSWNVLDGLLVLISVIDILVS---MVSDSGTKILGMLRVLRLLRTLRPLRVISRA 1395
Y R +WN+ D + V+ S+ +I+++ +V+ SG + L+L R R ++++ +
Sbjct: 1535 LNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFN----MSFLKLFRAARLIKLLRQG 1590
Query: 1396 QGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
+++++ T + S K + + ++ F I+ I+G+Q+F
Sbjct: 1591 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1629
Score = 72.0 bits (175), Expect = 4e-12
Identities = 50/196 (25%), Positives = 101/196 (51%), Gaps = 15/196 (7%)
Query: 1256 AYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAM---ERPKIDPHSAERIFLTL 1312
+Y + R+ ++ ++F +VL ++ LN +A+ +P+ H L
Sbjct: 456 SYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTH-----LLYY 510
Query: 1313 SNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTK 1372
+ ++F +FL EM++K+ +G + Y SS+N D + + S+ +++ ++ +
Sbjct: 511 AEFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSF 566
Query: 1373 ILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQ 1432
+ +LR LRLLR + + L+ +V +LMSS+K I +++ + F ++F +LG+Q
Sbjct: 567 GISVLRALRLLRIFK---ITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQ 623
Query: 1433 LFKGKFFVCQGEDTRN 1448
LF G+F G + N
Sbjct: 624 LFGGRFNFNDGTPSAN 639
Score = 60.8 bits (146), Expect = 1e-08
Identities = 52/168 (30%), Positives = 78/168 (46%), Gaps = 19/168 (11%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF---FAVEMVV 134
V +P FE M +I LN V L M S C A AF F++E V+
Sbjct: 1475 VVSPSFEYTIMAMIALNTVVLMM-------KYYSAPCTYELALKYLNIAFTMVFSLECVL 1527
Query: 135 KMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD---LQNVS---FSAVRTVRVLRPL 188
K++A G Y DTWN DF VI + E L L N S S ++ R R +
Sbjct: 1528 KVIAFGFLN---YFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLI 1584
Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
+ + + ++RIL+ + + L V LL +FFI+ I+G+Q++ +
Sbjct: 1585 KLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI 1632
Score = 51.2 bits (121), Expect = 8e-06
Identities = 33/121 (27%), Positives = 64/121 (52%), Gaps = 8/121 (6%)
Query: 120 FDDFIF-AFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLE--YSLDLQNVSF 176
+ +F+F F +EM +KM +G + Y ++N DF + + + E +++ SF
Sbjct: 510 YAEFLFLGLFLLEMSLKMYGMG---PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSF 566
Query: 177 --SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
S +R +R+LR + S+R LV L+ ++ + ++L L F +F ++G+QL+
Sbjct: 567 GISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626
Query: 235 G 235
G
Sbjct: 627 G 627
Score = 43.9 bits (102), Expect = 0.001
Identities = 26/105 (24%), Positives = 53/105 (50%), Gaps = 13/105 (12%)
Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH-----SFYNFIYFILLIIVGSFFMINLC 390
NFD A + +FQ++T E W ++MY + + ++ IYFI+L + G++ ++N+
Sbjct: 639 NFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVF 698
Query: 391 LVVI------ATQFSETKQRESQLMREQRVRFLSNASTLASFSEP 429
L + A + ++ +Q E + ++ L A ++ S P
Sbjct: 699 LAIAVDNLANAQELTKDEQEEEEAFNQKHA--LQKAKEVSPMSAP 741
Score = 37.7 bits (86), Expect = 0.087
Identities = 25/106 (23%), Positives = 50/106 (47%), Gaps = 15/106 (14%)
Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMD----------AHSFYNFIYFILLIIVGSFF 385
++DNI +A + +F V T EGW ++ +D ++ I++++ +V FF
Sbjct: 1354 HYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFF 1413
Query: 386 MINLCLVVIATQFSETKQR---ESQLMREQR--VRFLSNASTLASF 426
+N+ + +I F E + E L + +R + F +A L +
Sbjct: 1414 FVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRY 1459
>gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F
subunit [Homo sapiens]
Length = 1977
Score = 165 bits (418), Expect = 3e-40
Identities = 100/269 (37%), Positives = 153/269 (56%), Gaps = 15/269 (5%)
Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLV 796
R+ V S +++ + +NTL++ E+H QP LT E +N V LF +EMLLKL
Sbjct: 523 RRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYG 582
Query: 797 YGPFGYIKNPYNIFD-----GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPAL 851
GP Y+ + +N FD G I+ ++ E+ Q G+SVLR RL+R+ K+ R +L
Sbjct: 583 LGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASL 642
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911
+ L+ +M ++A+ +LL LFI IFS+LGM LFG KF ++ T R FD+
Sbjct: 643 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQ---THTKRSTFDTFPQ 699
Query: 912 AIVTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNLLVAILVE 965
A++TVFQILT EDWN V+Y+G+ + +YFI L GNY+L N+ +AI V+
Sbjct: 700 ALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVD 759
Query: 966 GFQAEEISKREDASGQLSCIQ-LPVDSQG 993
+ + +D G+ S + LP +++G
Sbjct: 760 NLASGDAGTAKDKGGEKSNEKDLPQENEG 788
Score = 152 bits (384), Expect = 2e-36
Identities = 116/413 (28%), Positives = 186/413 (45%), Gaps = 81/413 (19%)
Query: 28 AGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERIS 87
+ G G G+ ++ + + + +P F L+ + R C+ V F+ +
Sbjct: 39 SSGASGLGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILI 98
Query: 88 MLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFAVEMVVKMVALG-IFGKK 145
+L I NCV LG++ P + ++ + Q +++F F VE V+K+VA G +
Sbjct: 99 LLTIFANCVALGVYIPFPEDDSNTANHNLEQV--EYVFLVIFTVETVLKIVAYGLVLHPS 156
Query: 146 CYLGDTWNRLDFFIVIAGMLEYSLDLQ---------------NVSFSAVRTVRVLRPLRA 190
Y+ + WN LDF IV+ G+ L+ A+R RVLRPLR
Sbjct: 157 AYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRL 216
Query: 191 INRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLP 250
++ VPS+ I++ ++ L L ++ LL FV I+ I+G++L+ G + C+
Sbjct: 217 VSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYF------- 269
Query: 251 LSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSN 310
L D+E ED SP C S G G C L+
Sbjct: 270 LGSDME-----AEEDPSP-------------CAS-------SGSGRACTLN--------- 295
Query: 311 TTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF- 369
T C P G NFDN +A + +FQ +T+EGW D++Y++ DA +
Sbjct: 296 ---------QTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYE 346
Query: 370 YNFIYFILLIIVGSFFMINLCLVVIATQFSE-----------TKQRESQLMRE 411
++YF+ L+I GSFF++NL L V++ +FS+ KQRE Q M E
Sbjct: 347 LPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEE 399
Score = 127 bits (319), Expect = 8e-29
Identities = 73/216 (33%), Positives = 120/216 (55%), Gaps = 19/216 (8%)
Query: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVK 1328
CH +I H +F +++LV I L+ +++A E P I HS L +Y FT++F E+ +K
Sbjct: 864 CHTLIHHHVFTNLILVFIILSSVSLAAEDP-IRAHSFRNHILGYFDYAFTSIFTVEILLK 922
Query: 1329 VVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRP 1388
+ G ++ RS +N+LD L+V +S+I + + + ++++LR+LR LRP
Sbjct: 923 MTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIH------SSAISVVKILRVLRVLRP 976
Query: 1389 LRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRN 1448
LR I+RA+GLK VV+ + +++ IGNI+++ +F +GVQLFKGKF+ C E
Sbjct: 977 LRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHT 1036
Query: 1449 ---------ITNKSDCAEASYR---WVRHKYNFDNL 1472
+ D + R WV +NFDN+
Sbjct: 1037 PQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNV 1072
Score = 120 bits (302), Expect = 8e-27
Identities = 116/436 (26%), Positives = 192/436 (44%), Gaps = 81/436 (18%)
Query: 706 RDPHSRRQRSLGPDAEPSSVLAFWRLICDTFRK----IVDSKYFGRGIMIAILVNTLSMG 761
R+ HS+ + A+ S F + + R+ IV+ K F I++ I N +++G
Sbjct: 51 RNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALG 110
Query: 762 IEYHEQPEELTNA----LEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGV 813
+ Y PE+ +N LE VF +F +E +LK++ YG P YI+N +N+ D +
Sbjct: 111 V-YIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFI 169
Query: 814 IVVISVWEIVGQQGGG----------------LSVLRTFRLMRVLKLVRFLPALQRQLVV 857
IVV+ ++ ++ +QG G + LR FR++R L+LV +P+L L
Sbjct: 170 IVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNS 229
Query: 858 LMKTMDNVATFCMLLMLFIFIFSILGMHLF------GCKFAS---ERDGDTLPDRK---- 904
+MK + + +L++ I I++I+G+ LF C F E + D P
Sbjct: 230 IMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSG 289
Query: 905 ----------------------NFDSLLWAIVTVFQILTQEDWNKVLY---NGMASTSSW 939
NFD+ +A++TVFQ +T E W VLY + M W
Sbjct: 290 RACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPW 349
Query: 940 AALYFIALMTFGNYVLFNLLVAILVEGF--QAEEISKREDASGQLSCIQLPVDSQGG-DA 996
+YF++L+ FG++ + NL++ +L F + E+ R D Q Q+ D +G D
Sbjct: 350 --VYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDW 407
Query: 997 NKSESEPDFFSPSLD---------GDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1047
E D PS D G + LA ++ LR H+ ++
Sbjct: 408 ITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSH 467
Query: 1048 MSLPKSTSTGLGEALG 1063
SLP S + + E G
Sbjct: 468 ASLPASDTGSMTETQG 483
Score = 112 bits (281), Expect = 2e-24
Identities = 70/260 (26%), Positives = 135/260 (51%), Gaps = 34/260 (13%)
Query: 740 VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799
V+S F + + IL+NT+++ ++++EQ A++I N+VFT LF +EM+LK++ + P
Sbjct: 1187 VNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKP 1246
Query: 800 FGYIKNPYNIFDGVIVVISVWEIVGQQ---GG------------GLSVLRTFRLMRVLKL 844
Y + +N FD +IVV S+ +I + GG ++ R FR+MR++KL
Sbjct: 1247 KHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKL 1306
Query: 845 VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRK 904
+ ++ L +K+ + +L+ + FI++++GM +FG K A + DG +
Sbjct: 1307 LSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFG-KVALQ-DGTQINRNN 1364
Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-----------------SSWAALYFIAL 947
NF + A++ +F+ T E W +++ + S++A YFI+
Sbjct: 1365 NFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISF 1424
Query: 948 MTFGNYVLFNLLVAILVEGF 967
+++ NL VA++++ F
Sbjct: 1425 FMLCAFLIINLFVAVIMDNF 1444
Score = 112 bits (280), Expect = 3e-24
Identities = 95/386 (24%), Positives = 165/386 (42%), Gaps = 76/386 (19%)
Query: 38 EKDPGSADSEAEGLPYPALAPV----VFFYLSQDSRPRSWCLRTVCNPWFERISMLVILL 93
E+ G + E +P + P+ FF LSQ + R C + + F + ++ I+L
Sbjct: 824 EEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIIL 883
Query: 94 NCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTW- 152
+ V+L P I S R IL FD + F VE+++KM G F + +W
Sbjct: 884 SSVSLAAEDP---IRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWF 940
Query: 153 NRLDFFIVIAGMLEYSLDLQNVSFSAV-RTVRVLRPLRAINRVPSMRILVTLLLDTLPML 211
N LD +V ++ + + +S + R +RVLRPLRAINR ++ +V + + +
Sbjct: 941 NMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1000
Query: 212 GNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFIC 271
GN++++ + F+F +GVQL+ G + C
Sbjct: 1001 GNIMIVTTLLQFMFACIGVQLFKGKF-------------------------------YTC 1029
Query: 272 SQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPF 331
+ ++ + C+ + DG P + NS
Sbjct: 1030 TDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSD----------------------- 1066
Query: 332 KGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS-----FYNF-----IYFILLIIV 381
NFDN+ A +A+F V T EGW ++Y +DA++ YN+ ++FI+ II+
Sbjct: 1067 ---FNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIII 1123
Query: 382 GSFFMINLCLVVIATQFSETKQRESQ 407
+FFM+N+ + + F ++E Q
Sbjct: 1124 IAFFMMNIFVGFVIITFRAQGEQEYQ 1149
Score = 104 bits (260), Expect = 6e-22
Identities = 73/288 (25%), Positives = 131/288 (45%), Gaps = 14/288 (4%)
Query: 1183 LHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRA 1242
+ + G+ + E NG L P P ++G+ + G + R +
Sbjct: 1 MSESEGGKDTTPEPSPANGAGPGPEWG--LCPGPPAVEGESSGASGLGTPKRRNQHSKHK 58
Query: 1243 RLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERP-KID 1301
+ +R + + + R C I+ K FD ++L+ IF NC+ + + P D
Sbjct: 59 TVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPED 118
Query: 1302 PHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI 1361
+ L Y+F +F E +K+VA G AY+R+ WN+LD ++V++ + +
Sbjct: 119 DSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSV 178
Query: 1362 LVSM-------VSDSGTKILGM-LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1413
L+ +G K G ++ LR R LRPLR++S L +V+ ++M +L P+
Sbjct: 179 LLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLL 238
Query: 1414 NIVVICCAFFIIFGILGVQLFKGKFF-VCQ--GEDTRNITNKSDCAEA 1458
+I ++ II+ I+G++LF G+ C G D + S CA +
Sbjct: 239 HIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASS 286
Score = 80.5 bits (197), Expect = 1e-14
Identities = 46/183 (25%), Positives = 97/183 (53%), Gaps = 18/183 (9%)
Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
F++++ ++I LN + +AM+ + + + + N +FT +F EM +K++A F
Sbjct: 1192 FEYLMFLLILLNTVALAMQH--YEQTAPFNYAMDILNMVFTGLFTIEMVLKIIA----FK 1245
Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG---------MLRVLRLLRTLRP 1388
+ Y +WN D L+V+ S++DI V+ V++ G LG + RL R +R
Sbjct: 1246 PKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGH--LGESSEDSSRISITFFRLFRVMRL 1303
Query: 1389 LRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRN 1448
++++S+ +G++ ++ T + S + + + ++ F I+ ++G+Q+F GK + G
Sbjct: 1304 VKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMF-GKVALQDGTQINR 1362
Query: 1449 ITN 1451
N
Sbjct: 1363 NNN 1365
Score = 79.7 bits (195), Expect = 2e-14
Identities = 56/177 (31%), Positives = 93/177 (52%), Gaps = 17/177 (9%)
Query: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLT----LSNYIFTAVF 1321
R C R + VL+++FLN +TIA E H + ++LT +N + +F
Sbjct: 519 RARCRRAVKSNACYWAVLLLVFLNTLTIASE------HHGQPVWLTQIQEYANKVLLCLF 572
Query: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381
EM +K+ LG AY+ S +N D +V +++ ++V + LG + VLR
Sbjct: 573 TVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILE--TTLVEVGAMQPLG-ISVLR 625
Query: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1438
+R LR +V L +V +L++S+K I +++++ F IIF +LG+QLF GKF
Sbjct: 626 CVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF 682
Score = 70.5 bits (171), Expect = 1e-11
Identities = 70/306 (22%), Positives = 140/306 (45%), Gaps = 56/306 (18%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTN-ALEISNIVFTSLFALEMLLKLLVY 797
++ F I++ I+++++S+ E + N L + FTS+F +E+LLK+ V+
Sbjct: 867 LIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVF 926
Query: 798 GPF----GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRF------ 847
G F + ++ +N+ D ++V +S+ G +SV++ R++RVL+ +R
Sbjct: 927 GAFLHRGSFCRSWFNMLDLLVVSVSLISF-GIHSSAISVVKILRVLRVLRPLRAINRAKG 985
Query: 848 LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD----------G 897
L + + + V ++T+ N+ LL F+F+ +G+ LF KF + D G
Sbjct: 986 LKHVVQCVFVAIRTIGNIMIVTTLLQ---FMFACIGVQLFKGKFYTCTDEAKHTPQECKG 1042
Query: 898 DTL--PDRK----------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS- 938
L PD NFD++L A++ +F + T E W +LY + + +
Sbjct: 1043 SFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAED 1102
Query: 939 ---------WAALYFIALMTFGNYVLFNLLVAILVEGFQA---EEISKREDASGQLSCIQ 986
+++FI + + + N+ V ++ F+A +E E Q C++
Sbjct: 1103 HGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVE 1162
Query: 987 LPVDSQ 992
+ +Q
Sbjct: 1163 YALKAQ 1168
Score = 68.9 bits (167), Expect = 4e-11
Identities = 48/169 (28%), Positives = 85/169 (50%), Gaps = 11/169 (6%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
R+ C R V + +L++ LN +T+ + + +I + + + F V
Sbjct: 519 RARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLT----QIQEYANKVLLCLFTV 574
Query: 131 EMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTVRVLR 186
EM++K+ LG Y+ +NR D F+V G+LE +L +Q + S +R VR+LR
Sbjct: 575 EMLLKLYGLG---PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLR 631
Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
+ S+ LV LL+++ + ++LLL F IF ++G+QL+ G
Sbjct: 632 IFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 680
Score = 66.2 bits (160), Expect = 2e-10
Identities = 53/178 (29%), Positives = 86/178 (48%), Gaps = 25/178 (14%)
Query: 71 RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA-FFA 129
R W TV + FE + L+ILLN V L M + E A + IL + +F F
Sbjct: 1182 RVWA--TVNSAAFEYLMFLLILLNTVALAM-QHYEQTAPFNYAMDIL----NMVFTGLFT 1234
Query: 130 VEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGML--------------EYSLDLQNVS 175
+EMV+K++A F K Y D WN D IV+ ++ E S D +S
Sbjct: 1235 IEMVLKIIA---FKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRIS 1291
Query: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
+ R RV+R ++ +++ +R L+ + + L V LL +FFI+ ++G+Q++
Sbjct: 1292 ITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMF 1349
Score = 39.7 bits (91), Expect = 0.023
Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 6/63 (9%)
Query: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINLC 390
FD A + +FQ++T E W +MY + A+ F IYFI+L I G++ ++N+
Sbjct: 694 FDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVF 753
Query: 391 LVV 393
L +
Sbjct: 754 LAI 756
Score = 31.2 bits (69), Expect = 8.2
Identities = 14/42 (33%), Positives = 20/42 (47%)
Query: 1114 GRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAG 1155
G P +++ G RR E +E ++EEE EEE G
Sbjct: 788 GLVPGVEKEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGG 829
>gi|110349767 calcium channel, voltage-dependent, L type, alpha 1S
subunit [Homo sapiens]
Length = 1873
Score = 160 bits (406), Expect = 7e-39
Identities = 93/255 (36%), Positives = 148/255 (58%), Gaps = 15/255 (5%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV SK F +++ + +NTLS+ E+H QP LT +I+N V SLF EML+K+ G
Sbjct: 428 IVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLG 487
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----GLSVLRTFRLMRVLKLVRFLPALQR 853
Y + +N FD +V + EI+ + G G+SVLR RL+R+ K+ ++ +L
Sbjct: 488 LRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSN 547
Query: 854 QLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAI 913
+ L+ ++ ++A+ +LL LFI IF++LGM LFG ++ E DT R NFD+ A+
Sbjct: 548 LVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFE---DTEVRRSNFDNFPQAL 604
Query: 914 VTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNLLVAILVEGF 967
++VFQ+LT EDW ++YNG+ + +YFI L GNY+L N+ +AI V+
Sbjct: 605 ISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNL 664
Query: 968 -QAEEISKREDASGQ 981
+AE ++ + A +
Sbjct: 665 AEAESLTSAQKAKAE 679
Score = 155 bits (391), Expect = 4e-37
Identities = 128/446 (28%), Positives = 203/446 (45%), Gaps = 88/446 (19%)
Query: 49 EGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIA 108
E LP P P F L+ ++ R C+ V FE I +L I NCV L ++ P +
Sbjct: 22 EILPRP---PRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDD 78
Query: 109 CDSQRCRILQAFDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEY 167
+S L+ + F F++E +K++A G +F + YL WN LDF IV G+
Sbjct: 79 NNSLNLG-LEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTV 137
Query: 168 SLDLQNVSFS---------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLG 212
L+ NV S A+R RVLRPLR ++ VPS+++++ + + L
Sbjct: 138 ILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLF 197
Query: 213 NVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICS 272
++ LL F+ I+ I+G++L+ G + C+ + + ENE+ SP C+
Sbjct: 198 HIALLVLFMVIIYAIIGLELFKGKMHKTCYF---------IGTDIVATVENEEPSP--CA 246
Query: 273 QPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFK 332
R R C T+ G + C G P
Sbjct: 247 --RTGSGRRC----TING------------------------------SECRGGWPGPNH 270
Query: 333 GAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCL 391
G +FDN G++ + ++Q IT+EGW D++Y+V DA + + +IYF+ LI++GSFF++NL L
Sbjct: 271 GITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVL 330
Query: 392 VVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRL 451
V++ +F TK+RE R T E E+L Y+ +I +
Sbjct: 331 GVLSGEF--TKEREKAKSR----------GTFQKLREKQQLDEDLRGYMSWITQ------ 372
Query: 452 AQVSRAAGVRVGLLSSPAPLGGQETQ 477
+V R G LS GG +T+
Sbjct: 373 GEVMDVEDFREGKLSLDE--GGSDTE 396
Score = 132 bits (333), Expect = 2e-30
Identities = 89/265 (33%), Positives = 142/265 (53%), Gaps = 20/265 (7%)
Query: 1221 GDDADDEGNLSKGERVRAWIRARLPACCLE-RDSWSAYIFPPQSRFRLLCHRIITHKMFD 1279
GDD +DE + R R +L + ++ S +IF P ++ R+LCHRI+ F
Sbjct: 743 GDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFT 802
Query: 1280 HVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQ 1339
+ +L+ I L+ +A E P I S L + FT+VF E+ +K+ G +
Sbjct: 803 NFILLFILLSSAALAAEDP-IRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKG 861
Query: 1340 AYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLK 1399
++ R+ +N+LD L+V +S L+SM +S + ++++LR+LR LRPLR I+RA+GLK
Sbjct: 862 SFCRNYFNMLDLLVVAVS----LISMGLESSA--ISVVKILRVLRVLRPLRAINRAKGLK 915
Query: 1400 LVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQG------EDTRN---IT 1450
VV+ + ++ IGNIV++ +F +GVQLFKGKFF C E+ R +
Sbjct: 916 HVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVY 975
Query: 1451 NKSDCAEASYR---WVRHKYNFDNL 1472
D + R WV ++FDN+
Sbjct: 976 KDGDPMQIELRHREWVHSDFHFDNV 1000
Score = 116 bits (290), Expect = 2e-25
Identities = 106/398 (26%), Positives = 176/398 (44%), Gaps = 78/398 (19%)
Query: 61 FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
FF S ++ R C R V WF +L ILL+ L P I DS R +IL+ F
Sbjct: 779 FFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDP---IRADSMRNQILKHF 835
Query: 121 DDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
D + F VE+V+KM G F K + + +N LD +V ++ L+ +S +
Sbjct: 836 DIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKI 895
Query: 180 -RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238
R +RVLRPLRAINR ++ +V + + +GN++L+ + F+F +GVQL+ +
Sbjct: 896 LRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLF----K 951
Query: 239 NRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPC 298
+ F + S + YY + + I + RE
Sbjct: 952 GKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHRE---------------------- 989
Query: 299 GLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
W H+ F +FDN+ A +++F V T EGW
Sbjct: 990 -----------------W----------VHSDF----HFDNVLSAMMSLFTVSTFEGWPQ 1018
Query: 359 IMYFVMDAHS-----FYN-----FIYFILLIIVGSFFMINLCLVVIATQF---SETKQRE 405
++Y +D+++ YN I+FI+ II+ +FFM+N+ + + F ET+ +
Sbjct: 1019 LLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKN 1078
Query: 406 SQLMREQR--VRFLSNASTLASFSEPGSCYEELLKYLV 441
+L + QR V++ A L + P + Y+ + Y+V
Sbjct: 1079 CELDKNQRQCVQYALKARPLRCYI-PKNPYQYQVWYIV 1115
Score = 115 bits (289), Expect = 3e-25
Identities = 73/273 (26%), Positives = 138/273 (50%), Gaps = 46/273 (16%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
IV S YF + I++NT+ +G++++ Q E++ + +I N+ FT +F LEM+LKL+ +
Sbjct: 1114 IVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFK 1173
Query: 799 PFGYIKNPYNIFDGVIVVISVWEIVGQQ--------------GGGL-------------S 831
GY +P+N+FD +IV+ S+ +++ + GGG +
Sbjct: 1174 ARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSA 1233
Query: 832 VLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF 891
R FR+MR++KL+ ++ L +K+ + +L+++ FI++++GM +FG K
Sbjct: 1234 FFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFG-KI 1292
Query: 892 ASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL----YNGMASTSS--------- 938
A DG + NF + A++ +F+ T E W ++L Y + S
Sbjct: 1293 ALV-DGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYT 1351
Query: 939 ----WAALYFIALMTFGNYVLFNLLVAILVEGF 967
+A YFI+ +++ NL VA++++ F
Sbjct: 1352 CGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF 1384
Score = 111 bits (277), Expect = 6e-24
Identities = 62/198 (31%), Positives = 111/198 (56%), Gaps = 9/198 (4%)
Query: 1249 LERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKI-DPHSAER 1307
L R + + ++ R C I+ K F+ ++L+ IF NC+ +A+ P D +++
Sbjct: 24 LPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLN 83
Query: 1308 IFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISV-------ID 1360
+ L Y F VF E +K++A G+ F + AYLRS WNVLD +V + V ++
Sbjct: 84 LGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVN 143
Query: 1361 ILVSMVSDSGTKILGM-LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVIC 1419
++ S + +K G+ ++ LR R LRPLR++S L++V+ ++ ++ P+ +I ++
Sbjct: 144 VIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLV 203
Query: 1420 CAFFIIFGILGVQLFKGK 1437
II+ I+G++LFKGK
Sbjct: 204 LFMVIIYAIIGLELFKGK 221
Score = 93.2 bits (230), Expect = 2e-18
Identities = 76/295 (25%), Positives = 136/295 (46%), Gaps = 64/295 (21%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS----NIVFTSLFALEMLLKL 794
IV+ K F I++ I N +++ + Y PE+ N+L + F +F++E +K+
Sbjct: 47 IVEWKPFETIILLTIFANCVALAV-YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKI 105
Query: 795 LVYGPF----GYIKNPYNIFDGVIVVISVWEIVGQQ--------------GGGLSV--LR 834
+ YG Y+++ +N+ D IV + V+ ++ +Q G GL V LR
Sbjct: 106 IAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALR 165
Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF------G 888
FR++R L+LV +P+LQ L + K M + +L++ + I++I+G+ LF
Sbjct: 166 AFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKT 225
Query: 889 CKFASE------------------------------RDGDTLPDR--KNFDSLLWAIVTV 916
C F R G P+ +FD+ ++++TV
Sbjct: 226 CYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTV 285
Query: 917 FQILTQEDWNKVLY-NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
+Q +T E W VLY A + W +YF+ L+ G++ + NL++ +L F E
Sbjct: 286 YQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKE 340
Score = 89.0 bits (219), Expect = 3e-17
Identities = 89/385 (23%), Positives = 171/385 (44%), Gaps = 69/385 (17%)
Query: 665 DSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLG------- 717
+ P A+ E E E+ D A +F D + + P S R R L
Sbjct: 712 EGIPTTAKLKIDEFESNVNEVKDPYPSA--DFPGDDEEDEPEIPLSPRPRPLAELQLKEK 769
Query: 718 --PDAEPSSVLAFW-----RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE 770
P E SS F R++C +IV++ +F I++ IL+++ ++ E + +
Sbjct: 770 AVPIPEASSFFIFSPTNKIRVLC---HRIVNATWFTNFILLFILLSSAALAAEDPIRADS 826
Query: 771 LTNA-LEISNIVFTSLFALEMLLKLLVYGPF----GYIKNPYNIFDGVIVVISVWEIVGQ 825
+ N L+ +I FTS+F +E++LK+ YG F + +N +N+ D ++V +S+ + G
Sbjct: 827 MRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISM-GL 885
Query: 826 QGGGLSVLRTFRLMRVLKLVRFL---PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSIL 882
+ +SV++ R++RVL+ +R + L+ + + + + ++ L F+F+ +
Sbjct: 886 ESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACI 945
Query: 883 GMHLFGCKFAS------------------ERDGDTLPDRK----------NFDSLLWAIV 914
G+ LF KF +DGD + +FD++L A++
Sbjct: 946 GVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMM 1005
Query: 915 TVFQILTQEDWNKVLYNGMASTSS----------WAALYFIALMTFGNYVLFNLLVAILV 964
++F + T E W ++LY + S + A++FI + + + N+ V ++
Sbjct: 1006 SLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVI 1065
Query: 965 EGFQAE---EISKREDASGQLSCIQ 986
FQ + E E Q C+Q
Sbjct: 1066 VTFQEQGETEYKNCELDKNQRQCVQ 1090
Score = 83.2 bits (204), Expect = 2e-15
Identities = 54/178 (30%), Positives = 99/178 (55%), Gaps = 17/178 (9%)
Query: 1265 FRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLT----LSNYIFTAV 1320
FR CH I+ K+F +V++I+ LN ++IA E H + ++LT ++N + ++
Sbjct: 421 FRWKCHDIVKSKVFYWLVILIVALNTLSIASE------HHNQPLWLTRLQDIANRVLLSL 474
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
F EM +K+ LG + Y S +N D +V +++IL +V LG + VL
Sbjct: 475 FTTEMLMKMYGLGL----RQYFMSIFNRFDCFVVCSGILEIL--LVESGAMTPLG-ISVL 527
Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1438
R +R LR ++ L +V +L++S++ I +++++ F +IF +LG+QLF G++
Sbjct: 528 RCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY 585
Score = 79.3 bits (194), Expect = 3e-14
Identities = 52/210 (24%), Positives = 100/210 (47%), Gaps = 26/210 (12%)
Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
P++ ++ I+T F++++ +I LN I + M+ + + N FT +
Sbjct: 1103 PKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQH--YNQSEQMNHISDILNVAFTII 1160
Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVS-----MVSDSGTKILG 1375
F EM +K++A F + Y WNV D L+V+ S+ID+++S + S G LG
Sbjct: 1161 FTLEMILKLMA----FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLG 1216
Query: 1376 --------------MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCA 1421
RL R +R ++++SRA+G++ ++ T + S + + + ++
Sbjct: 1217 GGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVM 1276
Query: 1422 FFIIFGILGVQLFKGKFFVCQGEDTRNITN 1451
F I+ ++G+Q+F GK + G N
Sbjct: 1277 LFFIYAVIGMQMF-GKIALVDGTQINRNNN 1305
Score = 63.5 bits (153), Expect = 1e-09
Identities = 45/182 (24%), Positives = 81/182 (44%), Gaps = 33/182 (18%)
Query: 78 VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
V + +FE + +I+LN + LGM + Q I + F +EM++K++
Sbjct: 1115 VTSSYFEYLMFALIMLNTICLGM----QHYNQSEQMNHISDILNVAFTIIFTLEMILKLM 1170
Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL--------------------------DL 171
A F + Y GD WN DF IVI +++ L +
Sbjct: 1171 A---FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDES 1227
Query: 172 QNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQ 231
+S + R RV+R ++ ++R +R L+ + + L V LL +FFI+ ++G+Q
Sbjct: 1228 ARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ 1287
Query: 232 LW 233
++
Sbjct: 1288 MF 1289
Score = 63.2 bits (152), Expect = 2e-09
Identities = 54/208 (25%), Positives = 100/208 (48%), Gaps = 15/208 (7%)
Query: 35 GSAEKDPGSADSEAEGLPYPALAPVVFF--YLSQDSRPRSW-CLRTVCNPWFERISMLVI 91
G D G +D+E+ L ++ F + Q +R W C V + F + +L++
Sbjct: 384 GKLSLDEGGSDTESL-YEIAGLNKIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIV 442
Query: 92 LLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDT 151
LN +++ + + R+ + + + F EM++KM LG+ + Y
Sbjct: 443 ALNTLSIASEHHNQPLWLT----RLQDIANRVLLSLFTTEMLMKMYGLGL---RQYFMSI 495
Query: 152 WNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDT 207
+NR D F+V +G+LE L + + S +R +R+LR + S+ LV LL++
Sbjct: 496 FNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNS 555
Query: 208 LPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
+ + ++LLL F IF ++G+QL+ G
Sbjct: 556 IRSIASLLLLLFLFIVIFALLGMQLFGG 583
Score = 49.7 bits (117), Expect = 2e-05
Identities = 25/77 (32%), Positives = 43/77 (55%), Gaps = 6/77 (7%)
Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINL 389
NFDN A I++FQV+T E W +MY + A+ ++ IYFI+L + G++ ++N+
Sbjct: 596 NFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNV 655
Query: 390 CLVVIATQFSETKQRES 406
L + +E + S
Sbjct: 656 FLAIAVDNLAEAESLTS 672
>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
sapiens]
Length = 2506
Score = 158 bits (399), Expect = 4e-38
Identities = 157/540 (29%), Positives = 236/540 (43%), Gaps = 55/540 (10%)
Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLV 796
R++V ++ F ++ + +NTL + I ++ QPE L++ L + +F LF EM +K+
Sbjct: 480 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 539
Query: 797 YGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPAL 851
G Y + +N FD +++ S++E++ G+SVLR RL+R+ K+ ++ +L
Sbjct: 540 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 599
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911
+ +V L+ +M ++ + LL LFI +F++LGM LFG +F D T P NFD+
Sbjct: 600 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF--NFDEGTPP--TNFDTFPA 655
Query: 912 AIVTVFQILTQEDWNKVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEG 966
AI+TVFQILT EDWN+V+Y+G+ S ++YFI L FGNY L N+ +AI V+
Sbjct: 656 AIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDN 715
Query: 967 F-QAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
A+E++K E + + +L + A S S ++ +K V
Sbjct: 716 LANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWE 775
Query: 1026 GEHPELRKSLL-----------PPLIIHTAATPMSLPKSTSTGLGEAL--GPASRR---T 1069
E+RK L P AA L T L L P R T
Sbjct: 776 QRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNT 835
Query: 1070 SSSGSAEP---------GAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLK 1120
+ S +AEP A ++ P S ++ +RR S + L
Sbjct: 836 NKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDP-SGSAGLDARRPWAGS--QEAELS 892
Query: 1121 RRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHR---HRGSLEREAKSSFDLPDT 1177
R P G + EG Q E ER AG HR HR RE++S P T
Sbjct: 893 REGPYGRESDHHAREGSLEQPGFWEGEAERGK-AGDPHRRHVHRQGGSRESRSG--SPRT 949
Query: 1178 LQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVR 1237
G HR R A G R P G + + EG GER R
Sbjct: 950 -GADGEHR----RHRAHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGP-DGGERRR 1003
Score = 148 bits (373), Expect = 5e-35
Identities = 117/409 (28%), Positives = 187/409 (45%), Gaps = 79/409 (19%)
Query: 26 SGAGGRPGPGSAEKDPGSADSEAEGL--PYPALAPVV-----FFYLSQDSRPRSWCLRTV 78
S GG+PG K + + L P P + F S+D+ R + +
Sbjct: 36 SRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKIT 95
Query: 79 CNPWFERISMLVILLNCVTLGMFR--PCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKM 136
P FE + + I+ NC+ L + + P +D S+R L + + F E +K+
Sbjct: 96 EWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSER---LDDTEPYFIGIFCFEAGIKI 152
Query: 137 VALGI-FGKKCYLGDTWNRLDFFIVIAGMLEY---SLDLQNVSFSAVRTVRVLRPLRAIN 192
+ALG F K YL + WN +DF +V+ G+L DL+ + R VRVLRPL+ ++
Sbjct: 153 IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTL-----RAVRVLRPLKLVS 207
Query: 193 RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLS 252
+PS+++++ ++ + L + LL FF IF I+G++ + G CF
Sbjct: 208 GIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF---------- 257
Query: 253 VDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTT 312
E D+ G PCG + A T
Sbjct: 258 --------EEGTDDI-----------------------QGESPAPCGTEEPA------RT 280
Query: 313 CVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH-SFYN 371
C N T C P G FDNI +A + +FQ IT+EGW D++Y DA + +N
Sbjct: 281 CPNG----TKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWN 336
Query: 372 FIYFILLIIVGSFFMINLCLVVIATQFSETKQRES------QLMREQRV 414
++YFI LII+GSFFM+NL L V++ +F++ ++R +L R+Q++
Sbjct: 337 WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQI 385
Score = 134 bits (338), Expect = 5e-31
Identities = 74/227 (32%), Positives = 126/227 (55%), Gaps = 12/227 (5%)
Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSN 1314
S +I + R LCH I+ + F+ +L++I ++ I +A E P + P++ L +
Sbjct: 1222 SMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP-VQPNAPRNNVLRYFD 1280
Query: 1315 YIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL 1374
Y+FT VF EM +K++ LG + AY R WN+LD +++S + + +S K +
Sbjct: 1281 YVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILD--FIVVSGALVAFAFTGNSKGKDI 1338
Query: 1375 GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
++ LR+LR LRPL+ I R LK V + +++SLK + NI+++ F IF ++ VQLF
Sbjct: 1339 NTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLF 1398
Query: 1435 KGKFFVCQGE------DTRN---ITNKSDCAEASYRWVRHKYNFDNL 1472
KGKFF C E D R + K++ W ++++++DN+
Sbjct: 1399 KGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNV 1445
Score = 116 bits (290), Expect = 2e-25
Identities = 71/255 (27%), Positives = 137/255 (53%), Gaps = 24/255 (9%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
+ V S F IM I +NT+ + ++++ NAL + NIVFTSLF+LE +LK++ +
Sbjct: 1560 QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAF 1619
Query: 798 GPFGYIKNPYNIFDGVIVVISVWEIVGQQGG----GLSVLRTFRLMRVLKLVRFLPALQR 853
G Y ++ +NIFD V V+ S+ +I+ + G LS LR FR R++KL+R ++
Sbjct: 1620 GILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRI 1679
Query: 854 QLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT------LPDRKNFD 907
L +++ + C+L+ + FI++I+GM +FG D D+ + + NF
Sbjct: 1680 LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFR 1739
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGMAST--------------SSWAALYFIALMTFGNY 953
+ A++ +F+ T E W+ ++ + ++ + +A YF++ + ++
Sbjct: 1740 TFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSF 1799
Query: 954 VLFNLLVAILVEGFQ 968
++ NL VA++++ F+
Sbjct: 1800 LMLNLFVAVIMDNFE 1814
Score = 108 bits (269), Expect = 5e-23
Identities = 79/276 (28%), Positives = 131/276 (47%), Gaps = 43/276 (15%)
Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELT---NALEISNIVFTSLFALEMLLK 793
+KI + F I+ I+ N + + +E H ++ T L+ + F +F E +K
Sbjct: 92 KKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIK 151
Query: 794 LLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLP 849
++ G Y++N +N+ D V+V+ + VG + L LR R++R LKLV +P
Sbjct: 152 IIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD-LRTLRAVRVLRPLKLVSGIP 210
Query: 850 ALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF------------------ 891
+LQ L +MK M + +LL I IF+I+G+ + KF
Sbjct: 211 SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPA 270
Query: 892 --ASERDGDTLPDR--------------KNFDSLLWAIVTVFQILTQEDWNKVLYNGM-A 934
+E T P+ FD++L+A++TVFQ +T E W +LYN A
Sbjct: 271 PCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDA 330
Query: 935 STSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
S ++W LYFI L+ G++ + NL++ +L F E
Sbjct: 331 SGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKE 366
Score = 100 bits (250), Expect = 8e-21
Identities = 89/382 (23%), Positives = 155/382 (40%), Gaps = 85/382 (22%)
Query: 38 EKDPGSADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVT 97
EK D E P P F LS + R C + +FE ++VI ++ +
Sbjct: 1200 EKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIA 1259
Query: 98 LGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDTWNRLD 156
L P + ++ R +L+ FD F EMV+KM+ LG + + Y D WN LD
Sbjct: 1260 LAAEDPVQP---NAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILD 1316
Query: 157 FFIVIAGMLEYSL-------DLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP 209
F +V ++ ++ D+ + ++R +RVLRPL+ I R+P ++ + ++++L
Sbjct: 1317 FIVVSGALVAFAFTGNSKGKDINTIK--SLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 1374
Query: 210 MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPF 269
+ N+L++ FIF +V VQL+ G F
Sbjct: 1375 NVFNILIVYMLFMFIFAVVAVQLFKGKF-------------------------------F 1403
Query: 270 ICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHN 329
C+ + + CR L YE + W +Y
Sbjct: 1404 HCTDESKEFEKDCRGKYLL-------------YEKNEVKARDR--EWKKY---------- 1438
Query: 330 PFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYN-----------FIYFILL 378
++DN+ +A + +F V T EGW ++ +DA +F N I++++
Sbjct: 1439 ----EFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDA-TFENQGPSPGYRMEMSIFYVVY 1493
Query: 379 IIVGSFFMINLCLVVIATQFSE 400
+V FF +N+ + +I F E
Sbjct: 1494 FVVFPFFFVNIFVALIIITFQE 1515
Score = 97.8 bits (242), Expect = 7e-20
Identities = 62/203 (30%), Positives = 113/203 (55%), Gaps = 15/203 (7%)
Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHS---AERIFLT 1311
S ++F + R +I F++++L I NCI +A+E+ D +ER+ T
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 1312 LSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGT 1371
+I +F E +K++ALG+ F + +YLR+ WNV+D ++VL ++ + GT
Sbjct: 137 EPYFI--GIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATV-------GT 187
Query: 1372 KILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGV 1431
+ LR LR +R LRPL+++S L++V++++M ++ P+ I ++ +IF I+G+
Sbjct: 188 EF--DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGL 245
Query: 1432 QLFKGKFF-VCQGEDTRNITNKS 1453
+ + GKF C E T +I +S
Sbjct: 246 EFYMGKFHTTCFEEGTDDIQGES 268
Score = 92.8 bits (229), Expect = 2e-18
Identities = 70/303 (23%), Positives = 140/303 (46%), Gaps = 49/303 (16%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKL--- 794
I++ +YF I++ I ++++++ E QP N L + VFT +F EM++K+
Sbjct: 1239 ILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDL 1298
Query: 795 -LVYGPFGYIKNPYNIFDGVIV--VISVWEIVGQQGGG----LSVLRTFRLMRVLKLVRF 847
LV Y ++ +NI D ++V + + G G + LR R++R LK ++
Sbjct: 1299 GLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKR 1358
Query: 848 LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---------------- 891
LP L+ ++ ++ NV ++ MLF+FIF+++ + LF KF
Sbjct: 1359 LPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRG 1418
Query: 892 ---------ASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST------ 936
RD + ++D++LWA++T+F + T E W +VL + + +T
Sbjct: 1419 KYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGP 1478
Query: 937 ----SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS---GQLSCIQLPV 989
+++++ + N+ VA+++ FQ + E+ S + +CI +
Sbjct: 1479 SPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAI 1538
Query: 990 DSQ 992
++
Sbjct: 1539 SAK 1541
Score = 80.5 bits (197), Expect = 1e-14
Identities = 55/208 (26%), Positives = 108/208 (51%), Gaps = 12/208 (5%)
Query: 1241 RARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1300
RA + + LE S + + R R R++ + F VL ++ LN + +A+
Sbjct: 454 RASIKSAKLEN---STFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ 510
Query: 1301 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1360
++ FL + +IF +F++EM +K+ LG + Y SS+N D +++ S+ +
Sbjct: 511 PEWLSD--FLYYAEFIFLGLFMSEMFIKMYGLG----TRPYFHSSFNCFDCGVIIGSIFE 564
Query: 1361 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1420
++ +++ + + +LR LRLLR + V L+ +V +L++S+K I +++ +
Sbjct: 565 VIWAVIKPGTSFGISVLRALRLLRIFK---VTKYWASLRNLVVSLLNSMKSIISLLFLLF 621
Query: 1421 AFFIIFGILGVQLFKGKFFVCQGEDTRN 1448
F ++F +LG+QLF G+F +G N
Sbjct: 622 LFIVVFALLGMQLFGGQFNFDEGTPPTN 649
Score = 79.3 bits (194), Expect = 3e-14
Identities = 64/230 (27%), Positives = 115/230 (50%), Gaps = 25/230 (10%)
Query: 1221 GDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSR--FRLLCHRIITHKMF 1278
GD +E +L K ER A I + A L R PQ++ F+ + + F
Sbjct: 1517 GDKMMEEYSLEKNER--ACIDFAISAKPLTRHM-------PQNKQSFQYRMWQFVVSPPF 1567
Query: 1279 DHVVLVIIFLNCITIAME--RPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCF 1336
++ ++ +I LN I + M+ + +A R+F N +FT++F E +KV+A F
Sbjct: 1568 EYTIMAMIALNTIVLMMKFYGASVAYENALRVF----NIVFTSLFSLECVLKVMA----F 1619
Query: 1337 GEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQ 1396
G Y R +WN+ D + VL S+ DIL V++ G + L LRL R R ++++ +
Sbjct: 1620 GILNYFRDAWNIFDFVTVLGSITDIL---VTEFGNNFIN-LSFLRLFRAARLIKLLRQGY 1675
Query: 1397 GLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDT 1446
+++++ T + S K + + ++ F I+ I+G+Q+F + ED+
Sbjct: 1676 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 1725
Score = 65.1 bits (157), Expect = 5e-10
Identities = 50/176 (28%), Positives = 88/176 (50%), Gaps = 16/176 (9%)
Query: 66 QDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF 125
Q + R W + V +P FE M +I LN + L M +A ++ L+ F+
Sbjct: 1552 QSFQYRMW--QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENA----LRVFNIVFT 1605
Query: 126 AFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGML-----EYSLDLQNVSFSAVR 180
+ F++E V+K++A GI Y D WN DF V+ + E+ + N+SF +R
Sbjct: 1606 SLFSLECVLKVMAFGILN---YFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSF--LR 1660
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
R R ++ + + ++RIL+ + + L V LL +FFI+ I+G+Q++ +
Sbjct: 1661 LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI 1716
Score = 51.6 bits (122), Expect = 6e-06
Identities = 36/121 (29%), Positives = 64/121 (52%), Gaps = 8/121 (6%)
Query: 120 FDDFIF-AFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLE--YSLDLQNVSF 176
+ +FIF F EM +KM LG + Y ++N D ++I + E +++ SF
Sbjct: 520 YAEFIFLGLFMSEMFIKMYGLGT---RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSF 576
Query: 177 --SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
S +R +R+LR + S+R LV LL+++ + ++L L F +F ++G+QL+
Sbjct: 577 GISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 636
Query: 235 G 235
G
Sbjct: 637 G 637
Score = 39.7 bits (91), Expect = 0.023
Identities = 20/82 (24%), Positives = 40/82 (48%), Gaps = 5/82 (6%)
Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH-----SFYNFIYFILLIIVGSFFMINLC 390
NFD A + +FQ++T E W ++MY + + IYFI+L + G++ ++N+
Sbjct: 649 NFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVF 708
Query: 391 LVVIATQFSETKQRESQLMREQ 412
L + + ++ E+
Sbjct: 709 LAIAVDNLANAQELTKDEQEEE 730
Score = 38.1 bits (87), Expect = 0.067
Identities = 56/252 (22%), Positives = 85/252 (33%), Gaps = 42/252 (16%)
Query: 450 RLAQVSRAAGVRVGLLSSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHH----- 504
R V G + + + L +E + + H HHHHHHHHH
Sbjct: 2169 RYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRK----HRQHHHHHHHHHHPPPPD 2224
Query: 505 ---YHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADC 561
Y RA + R + R M + ++SG+P +
Sbjct: 2225 KDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTST------ 2278
Query: 562 HLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPETLKEK--------ALVEVAAS 613
P R + P++PS S + + PP + +++ A AA+
Sbjct: 2279 ---PRRGRRQLPQTPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQQQAVARPGRAAT 2335
Query: 614 SGP-----PTLTSL--NIPP--GPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGP 664
SGP PT L + PP G S +E + G +S SP GA P
Sbjct: 2336 SGPRRYPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPGPARS----ESPRACRHGGARWP 2391
Query: 665 DSCPYCARAGAG 676
S P+ + G
Sbjct: 2392 ASGPHVSEGPPG 2403
Score = 32.3 bits (72), Expect = 3.7
Identities = 26/97 (26%), Positives = 42/97 (43%), Gaps = 21/97 (21%)
Query: 327 EHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM--------------DAHSFYNF 372
EHN NF A + +F+ T E W +IM + + + + +
Sbjct: 1734 EHN------NFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAY 1787
Query: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLM 409
YF+ I + SF M+NL + VI F E R+S ++
Sbjct: 1788 FYFVSFIFLCSFLMLNLFVAVIMDNF-EYLTRDSSIL 1823
>gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo
sapiens]
Length = 2261
Score = 158 bits (399), Expect = 4e-38
Identities = 157/540 (29%), Positives = 236/540 (43%), Gaps = 55/540 (10%)
Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLV 796
R++V ++ F ++ + +NTL + I ++ QPE L++ L + +F LF EM +K+
Sbjct: 481 RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540
Query: 797 YGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPAL 851
G Y + +N FD +++ S++E++ G+SVLR RL+R+ K+ ++ +L
Sbjct: 541 LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600
Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911
+ +V L+ +M ++ + LL LFI +F++LGM LFG +F D T P NFD+
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF--NFDEGTPP--TNFDTFPA 656
Query: 912 AIVTVFQILTQEDWNKVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEG 966
AI+TVFQILT EDWN+V+Y+G+ S ++YFI L FGNY L N+ +AI V+
Sbjct: 657 AIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDN 716
Query: 967 F-QAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
A+E++K E + + +L + A S S ++ +K V
Sbjct: 717 LANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWE 776
Query: 1026 GEHPELRKSLL-----------PPLIIHTAATPMSLPKSTSTGLGEAL--GPASRR---T 1069
E+RK L P AA L T L L P R T
Sbjct: 777 QRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNT 836
Query: 1070 SSSGSAEP---------GAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLK 1120
+ S +AEP A ++ P S ++ +RR S + L
Sbjct: 837 NKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDP-SGSAGLDARRPWAGS--QEAELS 893
Query: 1121 RRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHR---HRGSLEREAKSSFDLPDT 1177
R P G + EG Q E ER AG HR HR RE++S P T
Sbjct: 894 REGPYGRESDHHAREGSLEQPGFWEGEAERGK-AGDPHRRHVHRQGGSRESRSG--SPRT 950
Query: 1178 LQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVR 1237
G HR R A G R P G + + EG GER R
Sbjct: 951 -GADGEHR----RHRAHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGP-DGGERRR 1004
Score = 148 bits (373), Expect = 5e-35
Identities = 117/409 (28%), Positives = 187/409 (45%), Gaps = 79/409 (19%)
Query: 26 SGAGGRPGPGSAEKDPGSADSEAEGL--PYPALAPVV-----FFYLSQDSRPRSWCLRTV 78
S GG+PG K + + L P P + F S+D+ R + +
Sbjct: 36 SRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKIT 95
Query: 79 CNPWFERISMLVILLNCVTLGMFR--PCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKM 136
P FE + + I+ NC+ L + + P +D S+R L + + F E +K+
Sbjct: 96 EWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSER---LDDTEPYFIGIFCFEAGIKI 152
Query: 137 VALGI-FGKKCYLGDTWNRLDFFIVIAGMLEY---SLDLQNVSFSAVRTVRVLRPLRAIN 192
+ALG F K YL + WN +DF +V+ G+L DL+ + R VRVLRPL+ ++
Sbjct: 153 IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTL-----RAVRVLRPLKLVS 207
Query: 193 RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLS 252
+PS+++++ ++ + L + LL FF IF I+G++ + G CF
Sbjct: 208 GIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF---------- 257
Query: 253 VDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTT 312
E D+ G PCG + A T
Sbjct: 258 --------EEGTDDI-----------------------QGESPAPCGTEEPA------RT 280
Query: 313 CVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH-SFYN 371
C N T C P G FDNI +A + +FQ IT+EGW D++Y DA + +N
Sbjct: 281 CPNG----TKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWN 336
Query: 372 FIYFILLIIVGSFFMINLCLVVIATQFSETKQRES------QLMREQRV 414
++YFI LII+GSFFM+NL L V++ +F++ ++R +L R+Q++
Sbjct: 337 WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQI 385
Score = 134 bits (338), Expect = 5e-31
Identities = 74/227 (32%), Positives = 126/227 (55%), Gaps = 12/227 (5%)
Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSN 1314
S +I + R LCH I+ + F+ +L++I ++ I +A E P + P++ L +
Sbjct: 1223 SMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP-VQPNAPRNNVLRYFD 1281
Query: 1315 YIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL 1374
Y+FT VF EM +K++ LG + AY R WN+LD +++S + + +S K +
Sbjct: 1282 YVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILD--FIVVSGALVAFAFTGNSKGKDI 1339
Query: 1375 GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
++ LR+LR LRPL+ I R LK V + +++SLK + NI+++ F IF ++ VQLF
Sbjct: 1340 NTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLF 1399
Query: 1435 KGKFFVCQGE------DTRN---ITNKSDCAEASYRWVRHKYNFDNL 1472
KGKFF C E D R + K++ W ++++++DN+
Sbjct: 1400 KGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNV 1446
Score = 116 bits (290), Expect = 2e-25
Identities = 71/255 (27%), Positives = 137/255 (53%), Gaps = 24/255 (9%)
Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
+ V S F IM I +NT+ + ++++ NAL + NIVFTSLF+LE +LK++ +
Sbjct: 1561 QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAF 1620
Query: 798 GPFGYIKNPYNIFDGVIVVISVWEIVGQQGG----GLSVLRTFRLMRVLKLVRFLPALQR 853
G Y ++ +NIFD V V+ S+ +I+ + G LS LR FR R++KL+R ++
Sbjct: 1621 GILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRI 1680
Query: 854 QLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT------LPDRKNFD 907
L +++ + C+L+ + FI++I+GM +FG D D+ + + NF
Sbjct: 1681 LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFR 1740
Query: 908 SLLWAIVTVFQILTQEDWNKVLYNGMAST--------------SSWAALYFIALMTFGNY 953
+ A++ +F+ T E W+ ++ + ++ + +A YF++ + ++
Sbjct: 1741 TFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSF 1800
Query: 954 VLFNLLVAILVEGFQ 968
++ NL VA++++ F+
Sbjct: 1801 LMLNLFVAVIMDNFE 1815
Score = 108 bits (269), Expect = 5e-23
Identities = 79/276 (28%), Positives = 131/276 (47%), Gaps = 43/276 (15%)
Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELT---NALEISNIVFTSLFALEMLLK 793
+KI + F I+ I+ N + + +E H ++ T L+ + F +F E +K
Sbjct: 92 KKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIK 151
Query: 794 LLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLP 849
++ G Y++N +N+ D V+V+ + VG + L LR R++R LKLV +P
Sbjct: 152 IIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD-LRTLRAVRVLRPLKLVSGIP 210
Query: 850 ALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF------------------ 891
+LQ L +MK M + +LL I IF+I+G+ + KF
Sbjct: 211 SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPA 270
Query: 892 --ASERDGDTLPDR--------------KNFDSLLWAIVTVFQILTQEDWNKVLYNGM-A 934
+E T P+ FD++L+A++TVFQ +T E W +LYN A
Sbjct: 271 PCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDA 330
Query: 935 STSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
S ++W LYFI L+ G++ + NL++ +L F E
Sbjct: 331 SGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKE 366
Score = 100 bits (250), Expect = 8e-21
Identities = 89/382 (23%), Positives = 155/382 (40%), Gaps = 85/382 (22%)
Query: 38 EKDPGSADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVT 97
EK D E P P F LS + R C + +FE ++VI ++ +
Sbjct: 1201 EKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIA 1260
Query: 98 LGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDTWNRLD 156
L P + ++ R +L+ FD F EMV+KM+ LG + + Y D WN LD
Sbjct: 1261 LAAEDPVQP---NAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILD 1317
Query: 157 FFIVIAGMLEYSL-------DLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP 209
F +V ++ ++ D+ + ++R +RVLRPL+ I R+P ++ + ++++L
Sbjct: 1318 FIVVSGALVAFAFTGNSKGKDINTIK--SLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 1375
Query: 210 MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPF 269
+ N+L++ FIF +V VQL+ G F
Sbjct: 1376 NVFNILIVYMLFMFIFAVVAVQLFKGKF-------------------------------F 1404
Query: 270 ICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHN 329
C+ + + CR L YE + W +Y
Sbjct: 1405 HCTDESKEFEKDCRGKYLL-------------YEKNEVKARDR--EWKKY---------- 1439
Query: 330 PFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYN-----------FIYFILL 378
++DN+ +A + +F V T EGW ++ +DA +F N I++++
Sbjct: 1440 ----EFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDA-TFENQGPSPGYRMEMSIFYVVY 1494
Query: 379 IIVGSFFMINLCLVVIATQFSE 400
+V FF +N+ + +I F E
Sbjct: 1495 FVVFPFFFVNIFVALIIITFQE 1516
Score = 97.8 bits (242), Expect = 7e-20
Identities = 62/203 (30%), Positives = 113/203 (55%), Gaps = 15/203 (7%)
Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHS---AERIFLT 1311
S ++F + R +I F++++L I NCI +A+E+ D +ER+ T
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 1312 LSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGT 1371
+I +F E +K++ALG+ F + +YLR+ WNV+D ++VL ++ + GT
Sbjct: 137 EPYFI--GIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATV-------GT 187
Query: 1372 KILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGV 1431
+ LR LR +R LRPL+++S L++V++++M ++ P+ I ++ +IF I+G+
Sbjct: 188 EF--DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGL 245
Query: 1432 QLFKGKFF-VCQGEDTRNITNKS 1453
+ + GKF C E T +I +S
Sbjct: 246 EFYMGKFHTTCFEEGTDDIQGES 268
Score = 92.8 bits (229), Expect = 2e-18
Identities = 70/303 (23%), Positives = 140/303 (46%), Gaps = 49/303 (16%)
Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKL--- 794
I++ +YF I++ I ++++++ E QP N L + VFT +F EM++K+
Sbjct: 1240 ILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDL 1299
Query: 795 -LVYGPFGYIKNPYNIFDGVIV--VISVWEIVGQQGGG----LSVLRTFRLMRVLKLVRF 847
LV Y ++ +NI D ++V + + G G + LR R++R LK ++
Sbjct: 1300 GLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKR 1359
Query: 848 LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---------------- 891
LP L+ ++ ++ NV ++ MLF+FIF+++ + LF KF
Sbjct: 1360 LPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRG 1419
Query: 892 ---------ASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST------ 936
RD + ++D++LWA++T+F + T E W +VL + + +T
Sbjct: 1420 KYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGP 1479
Query: 937 ----SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS---GQLSCIQLPV 989
+++++ + N+ VA+++ FQ + E+ S + +CI +
Sbjct: 1480 SPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAI 1539
Query: 990 DSQ 992
++
Sbjct: 1540 SAK 1542
Score = 80.5 bits (197), Expect = 1e-14
Identities = 55/208 (26%), Positives = 108/208 (51%), Gaps = 12/208 (5%)
Query: 1241 RARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1300
RA + + LE S + + R R R++ + F VL ++ LN + +A+
Sbjct: 455 RASIKSAKLEN---STFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ 511
Query: 1301 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1360
++ FL + +IF +F++EM +K+ LG + Y SS+N D +++ S+ +
Sbjct: 512 PEWLSD--FLYYAEFIFLGLFMSEMFIKMYGLG----TRPYFHSSFNCFDCGVIIGSIFE 565
Query: 1361 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1420
++ +++ + + +LR LRLLR + V L+ +V +L++S+K I +++ +
Sbjct: 566 VIWAVIKPGTSFGISVLRALRLLRIFK---VTKYWASLRNLVVSLLNSMKSIISLLFLLF 622
Query: 1421 AFFIIFGILGVQLFKGKFFVCQGEDTRN 1448
F ++F +LG+QLF G+F +G N
Sbjct: 623 LFIVVFALLGMQLFGGQFNFDEGTPPTN 650
Score = 79.3 bits (194), Expect = 3e-14
Identities = 64/230 (27%), Positives = 115/230 (50%), Gaps = 25/230 (10%)
Query: 1221 GDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSR--FRLLCHRIITHKMF 1278
GD +E +L K ER A I + A L R PQ++ F+ + + F
Sbjct: 1518 GDKMMEEYSLEKNER--ACIDFAISAKPLTRHM-------PQNKQSFQYRMWQFVVSPPF 1568
Query: 1279 DHVVLVIIFLNCITIAME--RPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCF 1336
++ ++ +I LN I + M+ + +A R+F N +FT++F E +KV+A F
Sbjct: 1569 EYTIMAMIALNTIVLMMKFYGASVAYENALRVF----NIVFTSLFSLECVLKVMA----F 1620
Query: 1337 GEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQ 1396
G Y R +WN+ D + VL S+ DIL V++ G + L LRL R R ++++ +
Sbjct: 1621 GILNYFRDAWNIFDFVTVLGSITDIL---VTEFGNNFIN-LSFLRLFRAARLIKLLRQGY 1676
Query: 1397 GLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDT 1446
+++++ T + S K + + ++ F I+ I+G+Q+F + ED+
Sbjct: 1677 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 1726
Score = 65.1 bits (157), Expect = 5e-10
Identities = 50/176 (28%), Positives = 88/176 (50%), Gaps = 16/176 (9%)
Query: 66 QDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF 125
Q + R W + V +P FE M +I LN + L M +A ++ L+ F+
Sbjct: 1553 QSFQYRMW--QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENA----LRVFNIVFT 1606
Query: 126 AFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGML-----EYSLDLQNVSFSAVR 180
+ F++E V+K++A GI Y D WN DF V+ + E+ + N+SF +R
Sbjct: 1607 SLFSLECVLKVMAFGILN---YFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSF--LR 1661
Query: 181 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
R R ++ + + ++RIL+ + + L V LL +FFI+ I+G+Q++ +
Sbjct: 1662 LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI 1717
Score = 51.6 bits (122), Expect = 6e-06
Identities = 36/121 (29%), Positives = 64/121 (52%), Gaps = 8/121 (6%)
Query: 120 FDDFIF-AFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLE--YSLDLQNVSF 176
+ +FIF F EM +KM LG + Y ++N D ++I + E +++ SF
Sbjct: 521 YAEFIFLGLFMSEMFIKMYGLGT---RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSF 577
Query: 177 --SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
S +R +R+LR + S+R LV LL+++ + ++L L F +F ++G+QL+
Sbjct: 578 GISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 637
Query: 235 G 235
G
Sbjct: 638 G 638
Score = 39.7 bits (91), Expect = 0.023
Identities = 20/82 (24%), Positives = 40/82 (48%), Gaps = 5/82 (6%)
Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH-----SFYNFIYFILLIIVGSFFMINLC 390
NFD A + +FQ++T E W ++MY + + IYFI+L + G++ ++N+
Sbjct: 650 NFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVF 709
Query: 391 LVVIATQFSETKQRESQLMREQ 412
L + + ++ E+
Sbjct: 710 LAIAVDNLANAQELTKDEQEEE 731
Score = 34.7 bits (78), Expect = 0.74
Identities = 10/13 (76%), Positives = 11/13 (84%)
Query: 493 HLVHHHHHHHHHY 505
H HHHHHHHHH+
Sbjct: 2208 HRQHHHHHHHHHH 2220
Score = 33.9 bits (76), Expect = 1.3
Identities = 15/55 (27%), Positives = 21/55 (38%), Gaps = 4/55 (7%)
Query: 450 RLAQVSRAAGVRVGLLSSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHH 504
R V G + + + L +E + + H HHHHHHHHH
Sbjct: 2170 RYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRK----HRQHHHHHHHHHH 2220
Score = 33.1 bits (74), Expect = 2.1
Identities = 9/10 (90%), Positives = 10/10 (100%)
Query: 497 HHHHHHHHYH 506
HHHHHHHH+H
Sbjct: 2211 HHHHHHHHHH 2220
Score = 32.3 bits (72), Expect = 3.7
Identities = 26/97 (26%), Positives = 42/97 (43%), Gaps = 21/97 (21%)
Query: 327 EHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM--------------DAHSFYNF 372
EHN NF A + +F+ T E W +IM + + + + +
Sbjct: 1735 EHN------NFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAY 1788
Query: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLM 409
YF+ I + SF M+NL + VI F E R+S ++
Sbjct: 1789 FYFVSFIFLCSFLMLNLFVAVIMDNF-EYLTRDSSIL 1824
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,699,364
Number of Sequences: 37866
Number of extensions: 3478642
Number of successful extensions: 24624
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 235
Number of HSP's successfully gapped in prelim test: 403
Number of HSP's that attempted gapping in prelim test: 17846
Number of HSP's gapped (non-prelim): 3956
length of query: 1555
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1439
effective length of database: 13,855,062
effective search space: 19937434218
effective search space used: 19937434218
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.