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Search of human proteins with 12545406
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo
sapiens]
(870 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 1759 0.0
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 1753 0.0
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 180 6e-45
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 180 6e-45
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 178 2e-44
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 178 2e-44
gi|130502162 RAS protein activator like 3 [Homo sapiens] 163 6e-40
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 150 6e-36
gi|4759026 RAS protein activator like 1 [Homo sapiens] 137 4e-32
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 133 6e-31
gi|12545408 RAS p21 protein activator 2 [Homo sapiens] 122 1e-27
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 112 1e-24
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 108 3e-23
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 108 3e-23
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 105 1e-22
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 105 1e-22
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 105 1e-22
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 105 1e-22
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 105 2e-22
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 84 4e-16
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 74 4e-13
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 68 3e-11
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 66 2e-10
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 66 2e-10
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 65 3e-10
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 64 6e-10
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 64 6e-10
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 63 1e-09
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 63 1e-09
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 63 1e-09
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 1759 bits (4555), Expect = 0.0
Identities = 870/870 (100%), Positives = 870/870 (100%)
Query: 1 MKGWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCG 60
MKGWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCG
Sbjct: 1 MKGWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCG 60
Query: 61 DYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTD 120
DYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTD
Sbjct: 61 DYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTD 120
Query: 121 EISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKIS 180
EISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKIS
Sbjct: 121 EISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKIS 180
Query: 181 KQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYN 240
KQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYN
Sbjct: 181 KQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYN 240
Query: 241 SIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVK 300
SIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVK
Sbjct: 241 SIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVK 300
Query: 301 KGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGR 360
KGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGR
Sbjct: 301 KGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGR 360
Query: 361 PNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLV 420
PNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLV
Sbjct: 361 PNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLV 420
Query: 421 LHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEIT 480
LHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEIT
Sbjct: 421 LHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEIT 480
Query: 481 LSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKI 540
LSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKI
Sbjct: 481 LSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKI 540
Query: 541 MPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDRE 600
MPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDRE
Sbjct: 541 MPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDRE 600
Query: 601 ISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEK 660
ISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEK
Sbjct: 601 ISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEK 660
Query: 661 NEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVS 720
NEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVS
Sbjct: 661 NEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVS 720
Query: 721 GFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVN 780
GFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVN
Sbjct: 721 GFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVN 780
Query: 781 PFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERG 840
PFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERG
Sbjct: 781 PFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERG 840
Query: 841 AQQHVLKKLLAITELLQQKQNQYTKTNDVR 870
AQQHVLKKLLAITELLQQKQNQYTKTNDVR
Sbjct: 841 AQQHVLKKLLAITELLQQKQNQYTKTNDVR 870
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 1753 bits (4539), Expect = 0.0
Identities = 867/867 (100%), Positives = 867/867 (100%)
Query: 4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 63
WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY
Sbjct: 181 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 240
Query: 64 IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS 123
IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS
Sbjct: 241 IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS 300
Query: 124 FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE 183
FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE
Sbjct: 301 FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE 360
Query: 184 AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG 243
AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG
Sbjct: 361 AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG 420
Query: 244 DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY 303
DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY
Sbjct: 421 DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY 480
Query: 304 LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC 363
LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC
Sbjct: 481 LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC 540
Query: 364 FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI 423
FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI
Sbjct: 541 FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI 600
Query: 424 EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN 483
EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN
Sbjct: 601 EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN 660
Query: 484 KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE 543
KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE
Sbjct: 661 KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE 720
Query: 544 EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM 603
EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM
Sbjct: 721 EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM 780
Query: 604 EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED 663
EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED
Sbjct: 781 EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED 840
Query: 664 VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV 723
VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV
Sbjct: 841 VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV 900
Query: 724 FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI 783
FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI
Sbjct: 901 FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI 960
Query: 784 KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ 843
KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ
Sbjct: 961 KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ 1020
Query: 844 HVLKKLLAITELLQQKQNQYTKTNDVR 870
HVLKKLLAITELLQQKQNQYTKTNDVR
Sbjct: 1021 HVLKKLLAITELLQQKQNQYTKTNDVR 1047
Score = 55.8 bits (133), Expect = 2e-07
Identities = 33/107 (30%), Positives = 59/107 (55%), Gaps = 7/107 (6%)
Query: 2 KGWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGD 61
K W+HGK+ + A L G+ S+L+R SD PG + L F + N + F+I +
Sbjct: 349 KIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNEN-IQRFKICPTPNN 407
Query: 62 -YYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRV 107
+ +GGR ++S+ D+I +Y +++G Y + P P++D+ +V
Sbjct: 408 QFMMGGRYYNSIGDIIDHYRKEQ-IVEG----YYLKEPVPMQDQEQV 449
>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
sapiens]
Length = 1065
Score = 180 bits (456), Expect = 6e-45
Identities = 146/527 (27%), Positives = 249/527 (47%), Gaps = 29/527 (5%)
Query: 353 VHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKR 412
VH S+ G+ CF++ S+ F+ + + + WM+ L+ R P N R
Sbjct: 36 VHSSILGQDYCFEVTTSSGSK-----CFSCRSAAERDKWMENLR-----RAVHPNKDNSR 85
Query: 413 LRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLP 471
R L L + EA LP K C + L+ V A+T + + N W E F F +LP
Sbjct: 86 -RVEHILKLWVIEAKDLPAKK--KYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLP 142
Query: 472 P----DINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG 527
P ++ + T K KK ++ + + + + ++W+ + + P G PG
Sbjct: 143 PLRTVTVHLYRET-DKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPG 201
Query: 528 SL-RVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILLRIFLH 585
+ R++ARY I+P E Y EF E I L + AL + + + +AS L+ I
Sbjct: 202 PMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQS 261
Query: 586 E-KLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKI 644
K++ L + D +FR TLA+ +E+Y+K +++ AL + I +
Sbjct: 262 TGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKAL 321
Query: 645 MESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSV 704
ES ++CE+ PSK D+ + +L KI + + P L+ ++ ++
Sbjct: 322 YESDENCEVDPSKCSA-ADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQEC 380
Query: 705 QHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLA 764
+ + + R++S +FLR +CPAI++P +FN++ + P ARTL L+AK QNLA
Sbjct: 381 SSRGRPDIS--ERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLA 438
Query: 765 NLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTE-HSRTDLSRDLAALHE 823
N +FG+KE YM +N F++ M FL E+ N L +T DL R+L++LH
Sbjct: 439 NFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHS 498
Query: 824 ICVAHSDEL-RTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDV 869
+ +L +++ ++ G +L+ + T L Q TND+
Sbjct: 499 LLWEAVSQLEQSIVSKLGPLPRILRDV--HTALSTPGSGQLPGTNDL 543
>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
sapiens]
Length = 1132
Score = 180 bits (456), Expect = 6e-45
Identities = 146/527 (27%), Positives = 249/527 (47%), Gaps = 29/527 (5%)
Query: 353 VHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKR 412
VH S+ G+ CF++ S+ F+ + + + WM+ L+ R P N R
Sbjct: 132 VHSSILGQDYCFEVTTSSGSK-----CFSCRSAAERDKWMENLR-----RAVHPNKDNSR 181
Query: 413 LRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLP 471
R L L + EA LP K C + L+ V A+T + + N W E F F +LP
Sbjct: 182 -RVEHILKLWVIEAKDLPAKK--KYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLP 238
Query: 472 P----DINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG 527
P ++ + T K KK ++ + + + + ++W+ + + P G PG
Sbjct: 239 PLRTVTVHLYRET-DKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPG 297
Query: 528 SL-RVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILLRIFLH 585
+ R++ARY I+P E Y EF E I L + AL + + + +AS L+ I
Sbjct: 298 PMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQS 357
Query: 586 E-KLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKI 644
K++ L + D +FR TLA+ +E+Y+K +++ AL + I +
Sbjct: 358 TGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKAL 417
Query: 645 MESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSV 704
ES ++CE+ PSK D+ + +L KI + + P L+ ++ ++
Sbjct: 418 YESDENCEVDPSKCSA-ADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQEC 476
Query: 705 QHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLA 764
+ + + R++S +FLR +CPAI++P +FN++ + P ARTL L+AK QNLA
Sbjct: 477 SSRGRPDIS--ERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLA 534
Query: 765 NLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTE-HSRTDLSRDLAALHE 823
N +FG+KE YM +N F++ M FL E+ N L +T DL R+L++LH
Sbjct: 535 NFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHS 594
Query: 824 ICVAHSDEL-RTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDV 869
+ +L +++ ++ G +L+ + T L Q TND+
Sbjct: 595 LLWEAVSQLEQSIVSKLGPLPRILRDV--HTALSTPGSGQLPGTNDL 639
>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
Length = 1280
Score = 178 bits (451), Expect = 2e-44
Identities = 141/491 (28%), Positives = 240/491 (48%), Gaps = 38/491 (7%)
Query: 349 SVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGT 408
SV +H S+ G+ CF++ S+ F+ + + + WM+ L+ R P
Sbjct: 260 SVKPLHSSILGQDFCFEVTYLSGSK-----CFSCNSASERDKWMENLR-----RTVQPNK 309
Query: 409 SNKRLRQVSSLVLHIEEAHKL-PVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFV 466
N R R + L L I EA L P K + +C + L+ A+T ++ + N W E F
Sbjct: 310 DNCR-RAENVLRLWIIEAKDLAPKKKY---FCELCLDDTLFARTTSKTKADNIFWGEHFE 365
Query: 467 FDDLPPDINRFEITL----SNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLK 522
F LPP ++ + + K KK K+ + + + + ++W+ +S+ P K
Sbjct: 366 FFSLPP-LHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNK 424
Query: 523 GIEPG-SLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILL 580
G G S+R+++R+ I+P E+Y EF E + + L V +++ LA L+
Sbjct: 425 GKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALV 484
Query: 581 RIFLHEKLESLLLCTLNDREISMEDEATTL-FRATTLASTLMEQYMKATATQFVHHALKD 639
I L L E+ E L FR T+A+ +E+Y+K Q++H AL +
Sbjct: 485 HILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGE 544
Query: 640 SILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVE-KIFMASEILPPTLRYIYG 698
I + ES ++CE+ PSK +E ++ L + EL KI + + P L+ ++
Sbjct: 545 FIKALYESDENCEVDPSKCSSSELIDHQSN--LKMCCELAFCKIINSYCVFPRELKEVFA 602
Query: 699 CLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAK 758
++ ++ + + R++S +FLR +CPAI++P +FN++ + P +RTL L+AK
Sbjct: 603 SWKQQCLNRGKQDIS--ERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK 660
Query: 759 SVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHS-----RTD 813
+QNLAN +FG KE YM +N F++ M FL E+ N PDT ++ D
Sbjct: 661 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISN----PDTISNTPGFDGYID 716
Query: 814 LSRDLAALHEI 824
L R+L+ LH +
Sbjct: 717 LGRELSVLHSL 727
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 178 bits (451), Expect = 2e-44
Identities = 141/491 (28%), Positives = 240/491 (48%), Gaps = 38/491 (7%)
Query: 349 SVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGT 408
SV +H S+ G+ CF++ S+ F+ + + + WM+ L+ R P
Sbjct: 112 SVKPLHSSILGQDFCFEVTYLSGSK-----CFSCNSASERDKWMENLR-----RTVQPNK 161
Query: 409 SNKRLRQVSSLVLHIEEAHKL-PVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFV 466
N R R + L L I EA L P K + +C + L+ A+T ++ + N W E F
Sbjct: 162 DNCR-RAENVLRLWIIEAKDLAPKKKY---FCELCLDDTLFARTTSKTKADNIFWGEHFE 217
Query: 467 FDDLPPDINRFEITL----SNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLK 522
F LPP ++ + + K KK K+ + + + + ++W+ +S+ P K
Sbjct: 218 FFSLPP-LHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNK 276
Query: 523 GIEPG-SLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILL 580
G G S+R+++R+ I+P E+Y EF E + + L V +++ LA L+
Sbjct: 277 GKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALV 336
Query: 581 RIFLHEKLESLLLCTLNDREISMEDEATTL-FRATTLASTLMEQYMKATATQFVHHALKD 639
I L L E+ E L FR T+A+ +E+Y+K Q++H AL +
Sbjct: 337 HILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGE 396
Query: 640 SILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVE-KIFMASEILPPTLRYIYG 698
I + ES ++CE+ PSK +E ++ L + EL KI + + P L+ ++
Sbjct: 397 FIKALYESDENCEVDPSKCSSSELIDHQSN--LKMCCELAFCKIINSYCVFPRELKEVFA 454
Query: 699 CLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAK 758
++ ++ + + R++S +FLR +CPAI++P +FN++ + P +RTL L+AK
Sbjct: 455 SWKQQCLNRGKQDIS--ERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK 512
Query: 759 SVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHS-----RTD 813
+QNLAN +FG KE YM +N F++ M FL E+ N PDT ++ D
Sbjct: 513 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISN----PDTISNTPGFDGYID 568
Query: 814 LSRDLAALHEI 824
L R+L+ LH +
Sbjct: 569 LGRELSVLHSL 579
>gi|130502162 RAS protein activator like 3 [Homo sapiens]
Length = 1011
Score = 163 bits (413), Expect = 6e-40
Identities = 134/491 (27%), Positives = 227/491 (46%), Gaps = 31/491 (6%)
Query: 350 VYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTS 409
++ +H SL G P+CFQ+ S F+ + + + W++ +LR+ T
Sbjct: 248 IWPLHPSLLGEPHCFQVTWTGGSR-----CFSCRSAAERDRWIE------DLRRQFQPTQ 296
Query: 410 NKRLRQVSSLVLHIEEAHKLPVKHFTNP--YCNIYLNSVQVAKTHAREGQNPV-WSEEFV 466
+ R+ + L + + EA LP P ++L+ +A+T R G + W+E F
Sbjct: 297 DNVEREETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPRAGPGQLFWAERFH 356
Query: 467 FDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHAT--DEWFLLSSHIPLKGI 524
F+ LPP R + L S + + + + A + WF PL G
Sbjct: 357 FEALPP-ARRLSLRLRGLGPGSAVLGRVALALEELDAPRAPAAGLERWF------PLLGA 409
Query: 525 EPGS-LRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVC-GQDRTLLASILLRI 582
G+ LR R R +++P E Y E E + + AL Q + LA+ ++R+
Sbjct: 410 PAGAALRARIRARRLRVLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRV 469
Query: 583 FLHEKLESLLLCTLNDREISM-EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSI 641
L+ L E++ LFR TLA+ +++YMK A ++ L +
Sbjct: 470 LRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVV 529
Query: 642 LKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQ 701
++ S + CE+ PSK +E + + L N E+ E I + + P L ++ +
Sbjct: 530 RRLCASTEDCEVDPSKCPASE-LPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWR 588
Query: 702 KSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQ 761
++ + + + + R+V +FLRL+CPAIL P +F + D P+P ARTL L+AK +Q
Sbjct: 589 EACKERG--SEVLGPRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQ 646
Query: 762 NLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVP-ELPDTTEHSRTDLSRDLAA 820
NLAN FG KE YM +N F++ + M FLD++ V + + DL+ LA
Sbjct: 647 NLANRAPFGEKEAYMGFMNSFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAV 706
Query: 821 LH-EICVAHSD 830
LH ++C ++
Sbjct: 707 LHAQLCTIFAE 717
>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo
sapiens]
Length = 1343
Score = 150 bits (378), Expect = 6e-36
Identities = 129/506 (25%), Positives = 234/506 (46%), Gaps = 53/506 (10%)
Query: 353 VHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKR 412
VH S+ G+ CF++ ++ FA + + + W++ LQ R P N R
Sbjct: 209 VHSSILGQEFCFEVTTSSGTK-----CFACRSAAERDKWIENLQ-----RAVKPNKDNSR 258
Query: 413 LRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAR----EGQNPVWSEEFVFD 468
R + L L I EA +LP K YC + L+ + A+T ++ G W E F F+
Sbjct: 259 -RVDNVLKLWIIEARELPPKK--RYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFN 315
Query: 469 DLPPDINRFEITL----SNKTKKSKDPDILFMRCQLSRLQKGHATDEWF---LLSSHIPL 521
+LP + + L K KK K + + ++ L H T++W+ L +
Sbjct: 316 NLPA-VRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGS 374
Query: 522 KGIEPG------------------SLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYA 563
G+ G ++R++ARY I+P E Y EF E + +
Sbjct: 375 GGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAV 434
Query: 564 LS---HVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTL 620
L +V G++ A + + + + L +++ + ME E +FR TLA+
Sbjct: 435 LEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHL-IFRENTLATKA 493
Query: 621 MEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVE 680
+E+YM+ +++ A+ + I + ES+++CE+ P K + L + EL
Sbjct: 494 IEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQAN--LRMCCELAL 551
Query: 681 -KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFN 739
K+ + + P L+ ++ + + + + R++S +FLR +CPAI++P +F
Sbjct: 552 CKVVNSHCVFPRELKEVFASWRLRCAERGRED--IADRLISASLFLRFLCPAIMSPSLFG 609
Query: 740 IISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGN 799
++ + P +RTL L+AK +QNLAN +F +KE ++ +N F++ M FL E+ N
Sbjct: 610 LMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISN 669
Query: 800 VPELPDTTE-HSRTDLSRDLAALHEI 824
+ L +++ DL R+L+ LH +
Sbjct: 670 LDTLTNSSSFEGYIDLGRELSTLHAL 695
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 137 bits (345), Expect = 4e-32
Identities = 110/416 (26%), Positives = 195/416 (46%), Gaps = 41/416 (9%)
Query: 420 VLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEI 479
VLH + + ++P+ ++ S + + ++ + P W E ++P + +
Sbjct: 139 VLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGAPSPLRV 198
Query: 480 TLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEP------GSLRVRA 533
L + K+ + + LQ+ WF L +P E G+LRV+
Sbjct: 199 ELWDWDMVGKNDFLGMVEFSPKTLQQ-KPPKGWFRL---LPFPRAEEDSGGNLGALRVKV 254
Query: 534 RYSMEKIMPEEEYSEFKELILQK-----------ELHVVYALSHVCGQDRTLLASILLRI 582
R ++++P + Y EL+++ L ++ L+ G R LA+ L+++
Sbjct: 255 RLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELT--LGDCRQDLATKLVKL 312
Query: 583 FLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSIL 642
FL L L L RE++ + TLFR+ +LAS MEQ+MK ++H LK I
Sbjct: 313 FLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVIS 372
Query: 643 KIMESKQSCELSPSK--------------LEKNEDVNTNLTHLLNILSELVEKIFMASEI 688
++ E K+ EL P K L + + T+L L L +V+ I +
Sbjct: 373 RVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGR 432
Query: 689 LPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPS 746
PP +R + L + V+ ++P + ++ +SGF+FLR PAIL P++F++
Sbjct: 433 CPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHAD 492
Query: 747 PIAARTLILVAKSVQNLANL-VEFG-AKEPYMEGVNPFIKSNKHRMIMFLDELGNV 800
P +R+L+L+AK+VQ++ NL + G KE +M ++PF+ R+ FLD L +V
Sbjct: 493 PQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLVDV 548
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 133 bits (335), Expect = 6e-31
Identities = 103/405 (25%), Positives = 185/405 (45%), Gaps = 36/405 (8%)
Query: 419 LVLHIEEAHKLPVKHFT-NPYCNIYLNSV---QVAKTHA-REGQNPVWSEEFVFDDLPP- 472
L I E LP+ + +PY + L + KT R+ NP + E F F+ P
Sbjct: 147 LATRIVECQGLPIVNGQCDPYATVTLAGPFRSEAKKTKVKRKTNNPQFDEVFYFEVTRPC 206
Query: 473 -------------DINRFEITL---SNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLL- 515
D+++ EI + + K D + +R L L++ + + W+ L
Sbjct: 207 SYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSSYEAWYFLQ 266
Query: 516 ---SSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQK------ELHVVYALSH 566
+ LK + GSLR+ Y+ + + + YS ++L+L+ + L
Sbjct: 267 PRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSADVEPVSASAAHILGE 326
Query: 567 VCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMK 626
VC +++ A L+R+FLH + + E+ + T+FR +LAS +++ MK
Sbjct: 327 VC-REKQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLASKCIDETMK 385
Query: 627 ATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMAS 686
++H LK +I +I +S + CE+ P KL+ E++ N+ +L + + I +
Sbjct: 386 LAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDGENLENNMENLRQYVDRVFHAITESG 445
Query: 687 EILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPS 746
P + I+ L+++ ++ + +R VS F+FLR PAIL+P +F +
Sbjct: 446 VSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTD 505
Query: 747 PIAARTLILVAKSVQNLANLVEFGA---KEPYMEGVNPFIKSNKH 788
P +RTL L++K+VQ L +L + + KE YM F K+
Sbjct: 506 PQTSRTLTLISKTVQTLGSLSKSKSASFKESYMATFYEFFNEQKY 550
Score = 36.2 bits (82), Expect = 0.14
Identities = 33/129 (25%), Positives = 53/129 (41%), Gaps = 7/129 (5%)
Query: 413 LRQVSSLVLHIEEAHKLPV----KHFTNPYCNIYLNSVQVAKTHAREGQN-PVWSEEFVF 467
LR S+ + I EA LP + YC + L+ +V +T E P + E+F +
Sbjct: 8 LRVFQSVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDF-Y 66
Query: 468 DDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG 527
++P + ++ +D I + Q LQK H D WF L H+ G
Sbjct: 67 CEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQL-QHVDADSEVQG 125
Query: 528 SLRVRARYS 536
+ + R S
Sbjct: 126 KVHLELRLS 134
>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
Length = 849
Score = 122 bits (306), Expect = 1e-27
Identities = 94/380 (24%), Positives = 177/380 (46%), Gaps = 35/380 (9%)
Query: 419 LVLHIEEAHKLPVKH--FTNPYCNIYL-----NSVQVAKTHAREGQNPVWSEEFVFDDL- 470
LV+HI+ H LP+ + +PY + L N + K ++ NP ++E F F+
Sbjct: 173 LVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVK-KKTSNPQFNEIFYFEVTR 231
Query: 471 -------------PPDINRFEITLS--NKTKKSKDPDILFMRCQLSRLQKGHATDEWFLL 515
DI + EI + N +D + ++ ++ L+ + W+LL
Sbjct: 232 SSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLL 291
Query: 516 ----SSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQK------ELHVVYALS 565
+ + K + GSLR+ Y+ + ++P E Y K L+L+ Y LS
Sbjct: 292 QPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILS 351
Query: 566 HVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYM 625
+C +D+ L+R+ LH + + ++ +A T+FR +LA+ +++ M
Sbjct: 352 EIC-RDKNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMM 410
Query: 626 KATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMA 685
K ++ LK + +I +S +SCE+ P KL++ ++V N +L + +L I +
Sbjct: 411 KIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKS 470
Query: 686 SEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSP 745
S P + I+ L++ ++P + ++ VS FVFLR A+++P F++ P
Sbjct: 471 SMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHP 530
Query: 746 SPIAARTLILVAKSVQNLAN 765
RTL L++K++Q L +
Sbjct: 531 DAQTIRTLTLISKTIQTLGS 550
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 112 bits (281), Expect = 1e-24
Identities = 90/294 (30%), Positives = 147/294 (50%), Gaps = 15/294 (5%)
Query: 555 QKELHVVYALSHV--CGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFR 612
Q EL + AL++V C Q L A +L+ +F L LL + +E+ + D TLFR
Sbjct: 1218 QGELPIAMALANVVPCSQWDEL-ARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFR 1276
Query: 613 ATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQ-----SCELSPSKLEKNEDVNTN 667
+LAS +M K ++ L D +L+I+ + S E+ P++LE +E + N
Sbjct: 1277 GNSLASKIMTFCFKVYGATYLQKLL-DPLLRIVITSSDWQHVSFEVDPTRLEPSESLEEN 1335
Query: 668 LTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRL 727
+LL + + I +S PP LR + CL + V ++P N+ V +FLR
Sbjct: 1336 QRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNS---IGAVGSAMFLRF 1392
Query: 728 ICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNK 787
I PAI++P I+ P P R L L++K +Q++AN V F KE +M N F+KSN
Sbjct: 1393 INPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKEEHMRPFNDFVKSNF 1451
Query: 788 HRMIMFLDELGNVPELPDTTEHSRTDLS-RDLAALHEICVAHSDEL-RTLSNER 839
F ++ + D HS + +S ++ ALH + + +++ + LS+ R
Sbjct: 1452 DAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNR 1505
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 108 bits (269), Expect = 3e-23
Identities = 89/326 (27%), Positives = 147/326 (45%), Gaps = 46/326 (14%)
Query: 527 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 575
GSL++ R E ++P Y L+ + + S C QD +
Sbjct: 250 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 306
Query: 576 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 635
A+ LL++FL + L L L E+S E TLFR+ +LAS ME ++K Q++H
Sbjct: 307 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHG 366
Query: 636 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 677
L I K+ E K+ EL PSK+E + T HL +LS
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
Query: 678 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 735
L + ++ T R ++ + V+ ++P + + V+ F+ LR PAI++P
Sbjct: 427 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 482
Query: 736 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 793
++F++ +RTL+L+AK+VQN+ N+ AKE +ME + P ++ ++ F
Sbjct: 483 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDF 542
Query: 794 LDELGNVPELPDTTEHSRTDLSRDLA 819
+ +L D E DL R L+
Sbjct: 543 ------ITKLVDIEEKDELDLQRTLS 562
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 108 bits (269), Expect = 3e-23
Identities = 89/326 (27%), Positives = 147/326 (45%), Gaps = 46/326 (14%)
Query: 527 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 575
GSL++ R E ++P Y L+ + + S C QD +
Sbjct: 250 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 306
Query: 576 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 635
A+ LL++FL + L L L E+S E TLFR+ +LAS ME ++K Q++H
Sbjct: 307 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHG 366
Query: 636 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 677
L I K+ E K+ EL PSK+E + T HL +LS
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
Query: 678 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 735
L + ++ T R ++ + V+ ++P + + V+ F+ LR PAI++P
Sbjct: 427 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 482
Query: 736 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 793
++F++ +RTL+L+AK+VQN+ N+ AKE +ME + P ++ ++ F
Sbjct: 483 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDF 542
Query: 794 LDELGNVPELPDTTEHSRTDLSRDLA 819
+ +L D E DL R L+
Sbjct: 543 ------ITKLVDIEEKDELDLQRTLS 562
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 105 bits (263), Expect = 1e-22
Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%)
Query: 527 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 575
GSL++ R E ++P Y L+ + + S C QD +
Sbjct: 178 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 234
Query: 576 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 635
A+ LL++FL + L L L E+S E TLFR+ +LAS +E ++K Q++H
Sbjct: 235 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 294
Query: 636 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 677
L I K+ E K+ EL PSK+E + T HL +LS
Sbjct: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354
Query: 678 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 735
L + ++ T R ++ + V+ ++P + + V+ F+ LR PAI++P
Sbjct: 355 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 410
Query: 736 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 793
++F++ +RTL+L+AK+VQN+ N+ AKE +ME + P + H+ +
Sbjct: 411 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 466
Query: 794 LDELGNVPELPDTTEHSRTDLSRDLA 819
L + + +L D E DL R L+
Sbjct: 467 LKDF--ITKLVDIEEKDELDLQRTLS 490
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 105 bits (263), Expect = 1e-22
Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%)
Query: 527 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 575
GSL++ R E ++P Y L+ + + S C QD +
Sbjct: 250 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 306
Query: 576 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 635
A+ LL++FL + L L L E+S E TLFR+ +LAS +E ++K Q++H
Sbjct: 307 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 366
Query: 636 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 677
L I K+ E K+ EL PSK+E + T HL +LS
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
Query: 678 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 735
L + ++ T R ++ + V+ ++P + + V+ F+ LR PAI++P
Sbjct: 427 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 482
Query: 736 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 793
++F++ +RTL+L+AK+VQN+ N+ AKE +ME + P + H+ +
Sbjct: 483 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 538
Query: 794 LDELGNVPELPDTTEHSRTDLSRDLA 819
L + + +L D E DL R L+
Sbjct: 539 LKDF--ITKLVDIEEKDELDLQRTLS 562
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 105 bits (263), Expect = 1e-22
Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%)
Query: 527 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 575
GSL++ R E ++P Y L+ + + S C QD +
Sbjct: 178 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 234
Query: 576 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 635
A+ LL++FL + L L L E+S E TLFR+ +LAS +E ++K Q++H
Sbjct: 235 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 294
Query: 636 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 677
L I K+ E K+ EL PSK+E + T HL +LS
Sbjct: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354
Query: 678 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 735
L + ++ T R ++ + V+ ++P + + V+ F+ LR PAI++P
Sbjct: 355 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 410
Query: 736 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 793
++F++ +RTL+L+AK+VQN+ N+ AKE +ME + P + H+ +
Sbjct: 411 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 466
Query: 794 LDELGNVPELPDTTEHSRTDLSRDLA 819
L + + +L D E DL R L+
Sbjct: 467 LKDF--ITKLVDIEEKDELDLQRTLS 490
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 105 bits (263), Expect = 1e-22
Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%)
Query: 527 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 575
GSL++ R E ++P Y L+ + + S C QD +
Sbjct: 250 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 306
Query: 576 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 635
A+ LL++FL + L L L E+S E TLFR+ +LAS +E ++K Q++H
Sbjct: 307 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 366
Query: 636 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 677
L I K+ E K+ EL PSK+E + T HL +LS
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
Query: 678 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 735
L + ++ T R ++ + V+ ++P + + V+ F+ LR PAI++P
Sbjct: 427 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 482
Query: 736 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 793
++F++ +RTL+L+AK+VQN+ N+ AKE +ME + P + H+ +
Sbjct: 483 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 538
Query: 794 LDELGNVPELPDTTEHSRTDLSRDLA 819
L + + +L D E DL R L+
Sbjct: 539 LKDF--ITKLVDIEEKDELDLQRTLS 562
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 105 bits (261), Expect = 2e-22
Identities = 89/312 (28%), Positives = 147/312 (47%), Gaps = 30/312 (9%)
Query: 555 QKELHVVYALSHV--CGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFR 612
Q EL + AL++V C Q L A +L+ +F L LL + +E+ + D TLFR
Sbjct: 1218 QGELPIAMALANVVPCSQWDEL-ARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFR 1276
Query: 613 ATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQ-----SCELSPSKLEKNEDVNTN 667
+LAS +M K ++ L D +L+I+ + S E+ P++LE +E + N
Sbjct: 1277 GNSLASKIMTFCFKVYGATYLQKLL-DPLLRIVITSSDWQHVSFEVDPTRLEPSESLEEN 1335
Query: 668 LTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTR---------- 717
+LL + + I +S PP LR + CL ++ H T++ +
Sbjct: 1336 QRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQ 1395
Query: 718 --------VVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEF 769
V +FLR I PAI++P I+ P P R L L++K +Q++AN V F
Sbjct: 1396 RFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF 1455
Query: 770 GAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLS-RDLAALHEICVAH 828
KE +M N F+KSN F ++ + D HS + +S ++ ALH + +
Sbjct: 1456 -TKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNN 1514
Query: 829 SDEL-RTLSNER 839
+++ + LS+ R
Sbjct: 1515 QEKIGQYLSSNR 1526
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 84.3 bits (207), Expect = 4e-16
Identities = 67/233 (28%), Positives = 116/233 (49%), Gaps = 22/233 (9%)
Query: 174 WFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 233
W+HG +++ A LL++ G S+L+R S+ T G YSL R ++++ F + T F
Sbjct: 35 WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYT-GYSFK 93
Query: 234 MGGRYYNSIGDIIDHYRKEQIVEG-----YYLKEPVPMQDQEQVLNDTVDGKEIYNTIRR 288
G ++S+ D + H+ + ++ LK P P + +E + ++V T R
Sbjct: 94 FGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGR- 152
Query: 289 KTKDAFYKNI----VKKGYLLKK-GKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLI 343
T+D K+GYL K+ G K WK +F L + +L YF+ ++ + +P ++
Sbjct: 153 -TEDDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRN--ELKYFK-DQMSPEPIRIL 208
Query: 344 DLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQ 396
DL+ CS V D R NCF +V + FY +T +A++W+K L+
Sbjct: 209 DLTECSA-VQFDYSQERVNCFCLVFPFRT-----FYLCAKTGVEADEWIKILR 255
Score = 54.3 bits (129), Expect = 5e-07
Identities = 29/79 (36%), Positives = 43/79 (54%), Gaps = 1/79 (1%)
Query: 3 GWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDY 62
GWYHG L R AE L G GSYL+R+S+ G + LS ++ + V HF + +
Sbjct: 34 GWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAK-DSVKHFHVEYTGYSF 92
Query: 63 YIGGRRFSSLSDLIGYYSH 81
G FSSL D + ++++
Sbjct: 93 KFGFNEFSSLKDFVKHFAN 111
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 74.3 bits (181), Expect = 4e-13
Identities = 42/156 (26%), Positives = 83/156 (53%), Gaps = 13/156 (8%)
Query: 118 DTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHG 177
++DE++F KGD + N +ED W +G I ++ + PH W+ G
Sbjct: 13 ESDELAFNKGDTLKILN-MEDDQNWYKAELRGVEGFIPKNYIRV-----KPHP---WYSG 63
Query: 178 KISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGR 237
+IS+Q A +LM + +FL+R S+++PG++S+ + +Q FK+ + ++ +
Sbjct: 64 RISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFLWEE 123
Query: 238 YYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVL 273
+NS+ +++D YR I + K + ++D+E +L
Sbjct: 124 KFNSLNELVDFYRTTTIAK----KRQIFLRDEEPLL 155
Score = 63.9 bits (154), Expect = 6e-10
Identities = 39/138 (28%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Query: 4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRII-AMCGDY 62
WY G++ R +AEE L + G++LIRES+ PG F +S ++ + V HF+++ G Y
Sbjct: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVS-VNYGDQVQHFKVLREASGKY 118
Query: 63 YIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEI 122
++ +F+SL++L+ +Y + K + L P +A ++ D ++
Sbjct: 119 FLWEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFS-AQDPSQL 177
Query: 123 SFLKGDMFIVHNELEDGW 140
SF +GD+ V + W
Sbjct: 178 SFRRGDIIEVLERPDPHW 195
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 68.2 bits (165), Expect = 3e-11
Identities = 47/167 (28%), Positives = 82/167 (49%), Gaps = 14/167 (8%)
Query: 107 VRAILPYT-KVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGRE 165
+ AI Y K DE+SF +GD+ V NE E W + G I ++ +E
Sbjct: 1 MEAIAKYDFKATADDELSFKRGDILKVLNE-ECDQNWYKAELNGKDGFIPKNYIEM---- 55
Query: 166 EDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKIC 225
PH WF GKI + +A +L +FL+R S++ PGD+SL + ++Q FK+
Sbjct: 56 -KPHP---WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVL 111
Query: 226 PTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQV 272
++ + +NS+ +++D++R + + + ++D EQV
Sbjct: 112 RDGAGKYFLWVVKFNSLNELVDYHRSTSVSR----NQQIFLRDIEQV 154
Score = 64.3 bits (155), Expect = 5e-10
Identities = 43/140 (30%), Positives = 71/140 (50%), Gaps = 9/140 (6%)
Query: 4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIA-MCGDY 62
W+ GK+ R AEE L + G++LIRES+ PG F LS + N V HF+++ G Y
Sbjct: 60 WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLS-VKFGNDVQHFKVLRDGAGKY 118
Query: 63 YIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPV--APPEPVEDRRRVRAILPYTKVPDTD 120
++ +F+SL++L+ Y+ S + L + P +P V+A+ + D
Sbjct: 119 FLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPT----YVQALFDFDPQED-G 173
Query: 121 EISFLKGDMFIVHNELEDGW 140
E+ F +GD V + + W
Sbjct: 174 ELGFRRGDFIHVMDNSDPNW 193
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 65.9 bits (159), Expect = 2e-10
Identities = 71/257 (27%), Positives = 117/257 (45%), Gaps = 38/257 (14%)
Query: 4 WYHGKLDRTIAEERLRQAGKS-GSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIA-MCGD 61
++ G + R AE+ L Q G S G YL+R+S G F LS ++ +H+ I + G
Sbjct: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALS-VAHGRKAHHYTIERELNGT 73
Query: 62 YYI-GGRRFSSLSDLIGYYSHVS----CLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKV 116
Y I GGR +S +DL Y+S S CLLK P P+ V+
Sbjct: 74 YAIAGGRTHASPADLCHYHSQESDGLVCLLKK-----PFNRPQGVQ-------------- 114
Query: 117 PDTDEISFLKGDMFIVHNELEDGWMWVTNLRTD--EQGLIVEDLVEEVGREEDPHEGKIW 174
P T LK ++ + ++ W NL+ EQ +I + E HE W
Sbjct: 115 PKTGPFEDLKENL--IREYVKQTW----NLQGQALEQAIISQKPQLEKLIATTAHEKMPW 168
Query: 175 FHGKISKQEAYNLLMTVGQV-CSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 233
FHGKIS++E+ +++ + FL+R DN G Y+L + ++I +
Sbjct: 169 FHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDKTGKLS 227
Query: 234 M-GGRYYNSIGDIIDHY 249
+ G+ ++++ +++HY
Sbjct: 228 IPEGKKFDTLWQLVEHY 244
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 65.9 bits (159), Expect = 2e-10
Identities = 71/257 (27%), Positives = 117/257 (45%), Gaps = 38/257 (14%)
Query: 4 WYHGKLDRTIAEERLRQAGKS-GSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIA-MCGD 61
++ G + R AE+ L Q G S G YL+R+S G F LS ++ +H+ I + G
Sbjct: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALS-VAHGRKAHHYTIERELNGT 73
Query: 62 YYI-GGRRFSSLSDLIGYYSHVS----CLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKV 116
Y I GGR +S +DL Y+S S CLLK P P+ V+
Sbjct: 74 YAIAGGRTHASPADLCHYHSQESDGLVCLLKK-----PFNRPQGVQ-------------- 114
Query: 117 PDTDEISFLKGDMFIVHNELEDGWMWVTNLRTD--EQGLIVEDLVEEVGREEDPHEGKIW 174
P T LK ++ + ++ W NL+ EQ +I + E HE W
Sbjct: 115 PKTGPFEDLKENL--IREYVKQTW----NLQGQALEQAIISQKPQLEKLIATTAHEKMPW 168
Query: 175 FHGKISKQEAYNLLMTVGQV-CSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 233
FHGKIS++E+ +++ + FL+R DN G Y+L + ++I +
Sbjct: 169 FHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDKTGKLS 227
Query: 234 M-GGRYYNSIGDIIDHY 249
+ G+ ++++ +++HY
Sbjct: 228 IPEGKKFDTLWQLVEHY 244
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 65.1 bits (157), Expect = 3e-10
Identities = 72/317 (22%), Positives = 129/317 (40%), Gaps = 83/317 (26%)
Query: 4 WYHGKLDRTIAEERLRQ------AGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIA 57
W+H K+++ + E+L Q GK G++L+RES+ P + LSF + V H RI +
Sbjct: 532 WFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFW-RSGRVQHCRIRS 590
Query: 58 MCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVP 117
++G L Y +
Sbjct: 591 T---------------------------MEGGTLKYYL---------------------- 601
Query: 118 DTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHG 177
TD ++F I H T+LR E L + D V +PHE K W++
Sbjct: 602 -TDNLTFSSIYALIQHYR-------ETHLRCAEFELRLTDPVPN----PNPHESKPWYYD 649
Query: 178 KISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMG-G 236
+S+ EA ++LM + + +FL+R + + Y++ FR ++ +I F++G
Sbjct: 650 SLSRGEAEDMLMRIPRDGAFLIRKREGS-DSYAITFRARGKVKHCRI-NRDGRHFVLGTS 707
Query: 237 RYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQ-----DQEQVLNDT-------VDGKEIYN 284
Y+ S+ +++ +Y K + L+ PV + + E+ +N VD EI
Sbjct: 708 AYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINP 767
Query: 285 TIRRKTKDAFYKNIVKK 301
++ ++T A Y K+
Sbjct: 768 SMPQRTVKALYDYKAKR 784
Score = 53.1 bits (126), Expect = 1e-06
Identities = 52/190 (27%), Positives = 83/190 (43%), Gaps = 35/190 (18%)
Query: 2 KGWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGD 61
K WY+ L R AE+ L + + G++LIR+ + S+ ++F ++ V H RI
Sbjct: 644 KPWYYDSLSRGEAEDMLMRIPRDGAFLIRKRE-GSDSYAITFRAR-GKVKHCRINRDGRH 701
Query: 62 YYIG-GRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPP---------------------- 98
+ +G F SL +L+ YY S L + +L YPV P
Sbjct: 702 FVLGTSAYFESLVELVSYYEKHS-LYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYV 760
Query: 99 -----EPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHN-ELEDGWMWVTNLRTDEQG 152
P +R V+A+ Y K +DE+SF +G ++HN E G W + T Q
Sbjct: 761 DPSEINPSMPQRTVKALYDY-KAKRSDELSFCRG--ALIHNVSKEPGGWWKGDYGTRIQQ 817
Query: 153 LIVEDLVEEV 162
+ VE++
Sbjct: 818 YFPSNYVEDI 827
Score = 52.8 bits (125), Expect = 1e-06
Identities = 53/241 (21%), Positives = 102/241 (42%), Gaps = 36/241 (14%)
Query: 100 PVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMW-------------VTNL 146
P + R + I+ + K+ ++ D H + + +MW + +
Sbjct: 442 PSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADA 501
Query: 147 RTDEQGLIVEDLVEEVGREEDP---HEGKIWFHGKISKQEAYNLLM------TVGQVCSF 197
+ I + + EEV ++ P H G+ WFH K+ K+ + L+ T G+ +F
Sbjct: 502 KLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTF 561
Query: 198 LVRPSDNTPGDYSLYFRTNENIQRFKICPTPN----NQFMMGGRYYNSIGDIIDHYRKEQ 253
LVR S+ P DY+L F + +Q +I T ++ ++SI +I HYR+
Sbjct: 562 LVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETH 621
Query: 254 IVEGYY---LKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKG-YLLKKGK 309
+ + L +PVP + + Y+++ R + I + G +L++K +
Sbjct: 622 LRCAEFELRLTDPVPNPNPHE------SKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKRE 675
Query: 310 G 310
G
Sbjct: 676 G 676
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 63.9 bits (154), Expect = 6e-10
Identities = 60/208 (28%), Positives = 97/208 (46%), Gaps = 40/208 (19%)
Query: 174 WFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 233
WFHG +S +EA LL G+ SFLVR S + PGD+ L RT ++ + M
Sbjct: 112 WFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVM 171
Query: 234 M----------GGRYYNSIGDIIDHYRKEQIVE--GYYLKEPVPMQDQEQVLNDT-VDGK 280
+ GG ++S+ D+++HY+K +VE G L+ +Q LN T ++
Sbjct: 172 IRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQ-------LKQPLNTTRINAA 224
Query: 281 EIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESE------K 334
EI + +R +K A + VK+G+ W+ + L+ + +L+Y E K
Sbjct: 225 EIESRVRELSKLAETTDKVKQGF---------WEE-FETLQQQECKLLYSRKEGQRQENK 274
Query: 335 RATKPKGLIDLSVCSVYVVHDSLFGRPN 362
+ K ++ V V+HD G PN
Sbjct: 275 NKNRYKNILPFDHTRV-VLHD---GDPN 298
Score = 63.2 bits (152), Expect = 1e-09
Identities = 41/126 (32%), Positives = 63/126 (50%), Gaps = 8/126 (6%)
Query: 174 WFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 233
WFH I+ EA NLL+T G SFL RPS + PGD++L R N + KI T + +
Sbjct: 6 WFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDL 65
Query: 234 MGGRYYNSIGDIIDHYR------KEQIVEGYYLKEPVPMQD--QEQVLNDTVDGKEIYNT 285
GG + ++ +++ +Y KE+ + LK P+ D E+ + + GKE
Sbjct: 66 YGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKL 125
Query: 286 IRRKTK 291
+ K K
Sbjct: 126 LTEKGK 131
Score = 56.6 bits (135), Expect = 1e-07
Identities = 37/108 (34%), Positives = 54/108 (50%), Gaps = 9/108 (8%)
Query: 4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 63
W+H + AE L G GS+L R S PG F LS + + V H + I GDYY
Sbjct: 6 WFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLS-VRRNGAVTHIK-IQNTGDYY 63
Query: 64 --IGGRRFSSLSDLIGYYSHVSCLLKGE-----KLLYPVAPPEPVEDR 104
GG +F++L++L+ YY LK + +L YP+ +P +R
Sbjct: 64 DLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSER 111
Score = 56.2 bits (134), Expect = 1e-07
Identities = 34/86 (39%), Positives = 45/86 (52%), Gaps = 10/86 (11%)
Query: 4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLS---------QMNVVNHFR 54
W+HG L AE+ L + GK GS+L+RES PG FVLS + + V H
Sbjct: 112 WFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVM 171
Query: 55 IIAMCGDYYI-GGRRFSSLSDLIGYY 79
I Y + GG RF SL+DL+ +Y
Sbjct: 172 IRCQELKYDVGGGERFDSLTDLVEHY 197
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 63.9 bits (154), Expect = 6e-10
Identities = 42/139 (30%), Positives = 73/139 (52%), Gaps = 12/139 (8%)
Query: 120 DEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKI 179
+++SF KGD +V E + W +L T ++G I + V V D E + WF I
Sbjct: 95 EDLSFQKGDQMVVLEESGEWWK-ARSLATRKEGYIPSNYVARV----DSLETEEWFFKGI 149
Query: 180 SKQEAYNLLMTVGQVC-SFLVRPSDNTPGDYSLYF-----RTNENIQRFKICPTPNNQFM 233
S+++A L+ G + SF++R S+ T G YSL R + ++ +KI N F
Sbjct: 150 SRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFY 209
Query: 234 MGGR-YYNSIGDIIDHYRK 251
+ R ++++ +++DHY+K
Sbjct: 210 ISPRSTFSTLQELVDHYKK 228
Score = 40.8 bits (94), Expect = 0.006
Identities = 28/83 (33%), Positives = 45/83 (54%), Gaps = 7/83 (8%)
Query: 4 WYHGKLDRTIAEERLRQAGKS-GSYLIRESDRRPGSFVLSFLS----QMNVVNHFRIIAM 58
W+ + R AE +L G GS++IR+S+ GS+ LS Q + V H++I +
Sbjct: 144 WFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTL 203
Query: 59 -CGDYYIGGR-RFSSLSDLIGYY 79
G +YI R FS+L +L+ +Y
Sbjct: 204 DNGGFYISPRSTFSTLQELVDHY 226
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 62.8 bits (151), Expect = 1e-09
Identities = 40/138 (28%), Positives = 70/138 (50%), Gaps = 11/138 (7%)
Query: 119 TDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGK 178
T+++SF KG+ F + N E W ++ T + G I + V D + + W+ GK
Sbjct: 107 TEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPA----DSIQAEEWYFGK 162
Query: 179 ISKQEAYNLLMTVG-QVCSFLVRPSDNTPGDYSLYFR-----TNENIQRFKICPTPNNQF 232
+ +++A LL+ G Q FLVR S+ T G YSL R +N++ +KI N +
Sbjct: 163 MGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGY 222
Query: 233 MMGGR-YYNSIGDIIDHY 249
+ R ++++ ++ HY
Sbjct: 223 YITTRAQFDTLQKLVKHY 240
Score = 43.1 bits (100), Expect = 0.001
Identities = 33/104 (31%), Positives = 50/104 (48%), Gaps = 8/104 (7%)
Query: 4 WYHGKLDRTIAEERLRQAGKS-GSYLIRESDRRPGSFVLSFLSQMNV----VNHFRIIAM 58
WY GK+ R AE L G G +L+RES+ G++ LS + V H++I +
Sbjct: 158 WYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKL 217
Query: 59 -CGDYYIGGR-RFSSLSDLIGYYS-HVSCLLKGEKLLYPVAPPE 99
G YYI R +F +L L+ +Y+ H L + P P+
Sbjct: 218 DNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQ 261
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 62.8 bits (151), Expect = 1e-09
Identities = 41/142 (28%), Positives = 72/142 (50%), Gaps = 21/142 (14%)
Query: 120 DEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKI 179
D+++F KG+ F + N E W +L + + G I + V V D + + W+ GKI
Sbjct: 94 DDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV----DSIQAEEWYFGKI 149
Query: 180 SKQEAYNLLMTVGQVC-SFLVRPSDNTPGDYSLYFR-----TNENIQRFKICPTPNNQFM 233
+++A L++ G +FL+R S+ T G YSL R ++++ +KI +
Sbjct: 150 GRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI-----RKLD 204
Query: 234 MGGRY------YNSIGDIIDHY 249
MGG Y +NS+ +++ HY
Sbjct: 205 MGGYYITTRVQFNSVQELVQHY 226
Score = 48.1 bits (113), Expect = 3e-05
Identities = 31/87 (35%), Positives = 51/87 (58%), Gaps = 7/87 (8%)
Query: 4 WYHGKLDRTIAEERLRQAGK-SGSYLIRESDRRPGSFVLSF----LSQMNVVNHFRIIAM 58
WY GK+ R AE +L G G++LIRES+ G++ LS ++ + V H++I +
Sbjct: 144 WYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKL 203
Query: 59 -CGDYYIGGR-RFSSLSDLIGYYSHVS 83
G YYI R +F+S+ +L+ +Y V+
Sbjct: 204 DMGGYYITTRVQFNSVQELVQHYMEVN 230
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 62.8 bits (151), Expect = 1e-09
Identities = 41/142 (28%), Positives = 72/142 (50%), Gaps = 21/142 (14%)
Query: 120 DEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKI 179
D+++F KG+ F + N E W +L + + G I + V V D + + W+ GKI
Sbjct: 94 DDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV----DSIQAEEWYFGKI 149
Query: 180 SKQEAYNLLMTVGQVC-SFLVRPSDNTPGDYSLYFR-----TNENIQRFKICPTPNNQFM 233
+++A L++ G +FL+R S+ T G YSL R ++++ +KI +
Sbjct: 150 GRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI-----RKLD 204
Query: 234 MGGRY------YNSIGDIIDHY 249
MGG Y +NS+ +++ HY
Sbjct: 205 MGGYYITTRVQFNSVQELVQHY 226
Score = 48.1 bits (113), Expect = 3e-05
Identities = 31/87 (35%), Positives = 51/87 (58%), Gaps = 7/87 (8%)
Query: 4 WYHGKLDRTIAEERLRQAGK-SGSYLIRESDRRPGSFVLSF----LSQMNVVNHFRIIAM 58
WY GK+ R AE +L G G++LIRES+ G++ LS ++ + V H++I +
Sbjct: 144 WYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKL 203
Query: 59 -CGDYYIGGR-RFSSLSDLIGYYSHVS 83
G YYI R +F+S+ +L+ +Y V+
Sbjct: 204 DMGGYYITTRVQFNSVQELVQHYMEVN 230
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,198,378
Number of Sequences: 37866
Number of extensions: 1500273
Number of successful extensions: 4021
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 93
Number of HSP's successfully gapped in prelim test: 185
Number of HSP's that attempted gapping in prelim test: 3500
Number of HSP's gapped (non-prelim): 481
length of query: 870
length of database: 18,247,518
effective HSP length: 111
effective length of query: 759
effective length of database: 14,044,392
effective search space: 10659693528
effective search space used: 10659693528
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.