Search of human proteins with 38348729

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38348729 hypothetical protein LOC203238 [Homo sapiens]
         (1326 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38348729 hypothetical protein LOC203238 [Homo sapiens]            2581   0.0  
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    132   3e-30
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   125   2e-28
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   125   2e-28
gi|55770834 centromere protein F [Homo sapiens]                       125   3e-28
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   125   4e-28
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   125   4e-28
gi|71061468 centromere protein E [Homo sapiens]                       118   4e-26
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   117   6e-26
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   117   6e-26
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   115   4e-25
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   115   4e-25
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   114   8e-25
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    113   1e-24
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   112   2e-24
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   112   2e-24
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   111   5e-24
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   110   7e-24
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      110   1e-23
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   107   6e-23
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   107   1e-22
gi|32698688 citron [Homo sapiens]                                     106   1e-22
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   106   1e-22
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...   106   2e-22
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            105   4e-22
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       103   8e-22
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       103   8e-22
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        103   8e-22
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        103   8e-22
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        103   8e-22

>gi|38348729 hypothetical protein LOC203238 [Homo sapiens]
          Length = 1326

 Score = 2581 bits (6690), Expect = 0.0
 Identities = 1326/1326 (100%), Positives = 1326/1326 (100%)

Query: 1    MNLNTSSNTGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAEL 60
            MNLNTSSNTGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAEL
Sbjct: 1    MNLNTSSNTGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAEL 60

Query: 61   ASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQN 120
            ASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQN
Sbjct: 61   ASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQN 120

Query: 121  SELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTL 180
            SELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTL
Sbjct: 121  SELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTL 180

Query: 181  QEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEK 240
            QEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEK
Sbjct: 181  QEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEK 240

Query: 241  LETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFN 300
            LETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFN
Sbjct: 241  LETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFN 300

Query: 301  SEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLL 360
            SEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLL
Sbjct: 301  SEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLL 360

Query: 361  EKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENN 420
            EKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENN
Sbjct: 361  EKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENN 420

Query: 421  VKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACN 480
            VKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACN
Sbjct: 421  VKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACN 480

Query: 481  ELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEK 540
            ELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEK
Sbjct: 481  ELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEK 540

Query: 541  EKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELC 600
            EKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELC
Sbjct: 541  EKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELC 600

Query: 601  AVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCW 660
            AVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCW
Sbjct: 601  AVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCW 660

Query: 661  HRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQT 720
            HRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQT
Sbjct: 661  HRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQT 720

Query: 721  QREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVE 780
            QREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVE
Sbjct: 721  QREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVE 780

Query: 781  EKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVC 840
            EKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVC
Sbjct: 781  EKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVC 840

Query: 841  TGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHL 900
            TGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHL
Sbjct: 841  TGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHL 900

Query: 901  LIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLR 960
            LIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLR
Sbjct: 901  LIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLR 960

Query: 961  GHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQ 1020
            GHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQ
Sbjct: 961  GHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQ 1020

Query: 1021 LNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADK 1080
            LNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADK
Sbjct: 1021 LNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADK 1080

Query: 1081 NQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDK 1140
            NQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDK
Sbjct: 1081 NQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDK 1140

Query: 1141 ECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGPEVVACQ 1200
            ECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGPEVVACQ
Sbjct: 1141 ECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGPEVVACQ 1200

Query: 1201 AMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTACLRENASLQSIGSRDHSNL 1260
            AMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTACLRENASLQSIGSRDHSNL
Sbjct: 1201 AMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTACLRENASLQSIGSRDHSNL 1260

Query: 1261 SIPSRAPLPADTTGIGDFLPLKAELDTTYTFLKETFINTVPHALTSSHSSPVTMSANANR 1320
            SIPSRAPLPADTTGIGDFLPLKAELDTTYTFLKETFINTVPHALTSSHSSPVTMSANANR
Sbjct: 1261 SIPSRAPLPADTTGIGDFLPLKAELDTTYTFLKETFINTVPHALTSSHSSPVTMSANANR 1320

Query: 1321 PTQIGL 1326
            PTQIGL
Sbjct: 1321 PTQIGL 1326


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  132 bits (331), Expect = 3e-30
 Identities = 241/1169 (20%), Positives = 480/1169 (41%), Gaps = 137/1169 (11%)

Query: 73   EVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQ-------- 124
            +V + E    + E +L   R++    + AAE RL E   +Q +L A+  +LQ        
Sbjct: 839  QVSRQEEEMMAKEEELVKVREK----QLAAENRLTEMETLQSQLMAEKLQLQEQLQAETE 894

Query: 125  --AKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQE 182
              A+  E        +Q+ +E C   E  +EE +   Q+   E   + +    LE+ L+E
Sbjct: 895  LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE 954

Query: 183  ---ALEKHQREKNEMESHIRETALEEFRLQEEQWE--AERRELQFIVQEQDTAV---QNM 234
               A +K Q EK   E+ +++   E+  L+++  +   E++ L+  + E  T +   +  
Sbjct: 955  EESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014

Query: 235  HKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIE--AERA 292
             K + KL+ +H           ++LE   +REE+ R+E E T    RKLE +    +++ 
Sbjct: 1015 SKSLAKLKNKH-------EAMITDLEERLRREEKQRQELEKTR---RKLEGDSTDLSDQI 1064

Query: 293  AHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQE 352
            A L+++     +++++   E  LQ   A   E  A   +   + +E+ES     + + + 
Sbjct: 1065 AELQAQIAE--LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122

Query: 353  SFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKK---- 408
              A  N  EK+     + L E++E  K  + D        ++  S+ ++E+ + KK    
Sbjct: 1123 ERASRNKAEKQ----KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE 1178

Query: 409  ----HQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTD 464
                H+A + E  + + + +E + +    + +  + + K K         LE  R  L +
Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ-------TLENERGELAN 1231

Query: 465  -----YQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKE-------LSH 512
                  Q K +     +K   +L   + K +   +   EL DK+  +  E       LS 
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291

Query: 513  LHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKL---SQAFHKDAEEKLTF 569
              +K +      S L+ +LQ+     ++E  Q     ++L+++     +F +  EE+   
Sbjct: 1292 SDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA 1351

Query: 570  LHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVD-ALIADL----NRANEKIRHL 624
             H L + +     L  Q   M  K   S  C    E V   L  DL     R  EK+   
Sbjct: 1352 KHNLEKQI---ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY 1408

Query: 625  EYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLE---VQKR 681
            + + K K+     LQQ  +D    +  Q ++  +   +QKK  +L   E  +     ++R
Sbjct: 1409 DKLEKTKT----RLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER 1464

Query: 682  AQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPL 741
             +   E  EK  + L+ + ++ E+ + + +  ++L  Q + E   L+++   +  +++ L
Sbjct: 1465 DRAEAEAREKETKALS-LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL 1523

Query: 742  YSRSCAL-------STQRDFLQEQVNTFELFKLEIRTLAQALSTVEEK----KQEEAKMK 790
                 AL        TQ + L++++   E  KL +    QA+    E+    + E+++ K
Sbjct: 1524 EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEK 1583

Query: 791  KKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKF 850
            KK    L+R  R+ + A L   R K    + A+        K+    +    + +D+   
Sbjct: 1584 KKQ---LVRQVRE-MEAELEDER-KQRSMAVAARKKLEMDLKDLEAHIDSANKNRDE--- 1635

Query: 851  PKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFA 910
                 +QLR LQA       D +  +  + A  ++++ +A  N +          K+  A
Sbjct: 1636 ---AIKQLRKLQA----QMKDCMRELDDTRASREEILAQAKENEK--------KLKSMEA 1680

Query: 911  KLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTA 970
            ++   I L  E      ++     E+D L   +A+   K   LAL+   R    I +   
Sbjct: 1681 EM---IQLQEELAAAERAKRQAQQERDELADEIANSSGK-GALALEEKRRLEARIAQLEE 1736

Query: 971  SLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLI 1030
             L+++  G T+ ++      +   L++ +    +N  +    K +  + QL    +   +
Sbjct: 1737 ELEEE-QGNTELIND---RLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKV 1792

Query: 1031 THEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKS 1090
              ++ E   +    A +   +A++     AQ  ++L+ + +   +      +T  +    
Sbjct: 1793 KLQEMEGTVKSKYKASITALEAKI-----AQLEEQLDNETKERQAACKQVRRTEKKLKDV 1847

Query: 1091 LSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAV 1150
            L +   E R  +Q   Q ++  T+L+Q KR+LEE    AE   + A   +  +   +   
Sbjct: 1848 LLQVDDERRNAEQYKDQADKASTRLKQLKRQLEE----AEEEAQRANASRRKLQRELEDA 1903

Query: 1151 ENTLHKVRDQISLSWSAASRNDFTLQLPK 1179
              T   +  ++S   +   R D    +P+
Sbjct: 1904 TETADAMNREVSSLKNKLRRGDLPFVVPR 1932



 Score =  103 bits (256), Expect = 1e-21
 Identities = 189/832 (22%), Positives = 349/832 (41%), Gaps = 125/832 (15%)

Query: 26   LKNETELDITDNLRKKLHWAKKEKLEI----------TTKHNAELASYESQIAKLRSEVE 75
            LKN+ E  ITD L ++L   +K++ E+          +T  + ++A  ++QIA+L+ ++ 
Sbjct: 1021 LKNKHEAMITD-LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA 1079

Query: 76   KGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQ 135
            K E      E   A+AR E      AA++ +A   +I+E L +Q SELQ    E+E+A +
Sbjct: 1080 KKEE-----ELQAALARVE----EEAAQKNMA-LKKIRE-LESQISELQEDL-ESERASR 1127

Query: 136  TSQQKWKEEC-RRFEHDLEERDNMIQNCNREYDLLMKEKSR---LEKTLQEALEKHQREK 191
               +K K +     E    E ++ + +   + +L  K +     L+KTL+E  + H+ + 
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQI 1187

Query: 192  NEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKL-----ETEHM 246
             EM       A+EE   Q EQ +  +  L+   Q  +     +  +V+ L     ++EH 
Sbjct: 1188 QEMRQK-HSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHK 1246

Query: 247  DCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEA------ERAAHLESKFN 300
                 +  Q  EL+      ER+R E      +++   +N+         +++ L   F+
Sbjct: 1247 --RKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304

Query: 301  SEIIQLRIRDLEGALQVE---KASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKL 357
            +  ++ +++D +  LQ E   K S +  +  +E  KN F+E     E  KHN ++  A L
Sbjct: 1305 A--LESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362

Query: 358  NLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETC 417
            +    +     KK  ED     +   ++ ++LQ + +  S+  EE V A      L +T 
Sbjct: 1363 HAQVADM----KKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDK---LEKTK 1415

Query: 418  ENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEE- 476
                +EL+ +L       Q    + K + K        + +     + +++ E  + E+ 
Sbjct: 1416 TRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKE 1475

Query: 477  -------KACNELDSTKQKIDSHTKNIK-ELQDKLA---DVNKELSHLHTKCADREALIS 525
                   +A  E    K +++   K  + E++D ++   DV K +  L       E  + 
Sbjct: 1476 TKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVE 1535

Query: 526  TLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIK 585
             +K +L+ +    +  +    + E  LQ +   F +D + +        + LV     ++
Sbjct: 1536 EMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQ---VR 1592

Query: 586  QPEGMLDKFSWSELCAV-----LQENVDALIADLNRAN----EKIRHLEYICKNKSDTMR 636
            + E  L+        AV     L+ ++  L A ++ AN    E I+ L  +     D MR
Sbjct: 1593 EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652

Query: 637  ELQQT---QEDTFTKV-----------AEQIKAQE--SCWHRQKKELELQYSELFLEV-- 678
            EL  T   +E+   +            AE I+ QE  +   R K++ + +  EL  E+  
Sbjct: 1653 ELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712

Query: 679  ----------QKR------AQKFQEIAEK--NMEKLN--------HIEKSHEQLVLENSH 712
                      +KR      AQ  +E+ E+  N E +N         I++ +  L LE SH
Sbjct: 1713 SSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSH 1772

Query: 713  FKK---LLSQTQREQMSLLAACALMAGALYPLYSRS-CALSTQRDFLQEQVN 760
             +K      Q +R+   L      M G +   Y  S  AL  +   L+EQ++
Sbjct: 1773 AQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLD 1824



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 116/597 (19%), Positives = 257/597 (43%), Gaps = 43/597 (7%)

Query: 5    TSSNTGDTQRLKIASLDVKQILKNET--ELDITDNLRK----KLHWAKKEKLEITTKHNA 58
            +S  T D   L+    D +++L+ E   +L ++  L++    K  + ++ + E   KHN 
Sbjct: 1296 SSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355

Query: 59   E--LASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEA-GLGRRAAEERLAEAHRIQEK 115
            E  +A+  +Q+A ++ ++E      ++ E      +K+  GL +R  EE++A   ++++ 
Sbjct: 1356 EKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRH-EEKVAAYDKLEKT 1414

Query: 116  LCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLL---MKE 172
                  EL     + +   Q++    K++ ++F+  L E   +      E D      +E
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQ-KKFDQLLAEEKTISAKYAEERDRAEAEARE 1473

Query: 173  KSRLEKTLQEALEKHQREKNEMESHIRE--TALEEFRLQEE-------QWEAERRELQFI 223
            K     +L  ALE+   +K E+E   ++  T +E+    ++       + E  +R L+  
Sbjct: 1474 KETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533

Query: 224  VQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQ-REERLRKEFEATTLRVRK 282
            V+E  T ++ +  +++  E   +     L+   ++ E   Q R+E+  ++ +    +VR+
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVRE 1593

Query: 283  LEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESA 342
            +E  +E ER     +    + +++ ++DLE  +     ++ EA+  L  ++ + K+    
Sbjct: 1594 MEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE 1653

Query: 343  YEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEE 402
             +  + + +E  A+     KE   K K +  ++ + ++ +    +  +  ++   EL +E
Sbjct: 1654 LDDTRASREEILAQ----AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE 1709

Query: 403  ---------LVMAKKHQ-----AFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKP 448
                     L + +K +     A L E  E      E I D    +      I+ D +  
Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLE 1769

Query: 449  PSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNK 508
             S +   E  R+ L + QNK      +E         K  I +    I +L+++L +  K
Sbjct: 1770 RSHAQKNENARQQL-ERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETK 1828

Query: 509  ELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEE 565
            E      +    E  +  + +++ +     E+ K QA ++ + L++L +   +  EE
Sbjct: 1829 ERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEE 1885



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 49/240 (20%), Positives = 107/240 (44%), Gaps = 31/240 (12%)

Query: 972  LQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKE-----------LDKAQGLQMQ 1020
            +Q+ I    ++L   E  R+ L+LE    +  + ++++E             + + L+ +
Sbjct: 941  MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000

Query: 1021 LNEFKQSKLITHEKFESACEELNN--ALLREEQAQMLLNE-QAQQLQELNYKLELHSSEE 1077
            + EF  +     EK +S  +  N   A++ + + ++   E Q Q+L++   KLE  S++ 
Sbjct: 1001 IAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDL 1060

Query: 1078 ADKNQTLGEAVKSLSEAKMELRRKDQSLR-----------QLN---RHLTQLEQDKRRLE 1123
            +D+   + E    ++E KM+L +K++ L+           Q N   + + +LE     L+
Sbjct: 1061 SDQ---IAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117

Query: 1124 ENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLE 1183
            E++    ++   A K K  +   + A++  L    D  +      S+ +  + + K  LE
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLE 1177



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 45/198 (22%), Positives = 90/198 (45%), Gaps = 22/198 (11%)

Query: 64   ESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAH-----RIQEKLCA 118
            E++IA+L  E+E+ +   + +   L  A  +  + +   +  L  +H       +++L  
Sbjct: 1728 EARIAQLEEELEEEQGNTELINDRLKKANLQ--IDQINTDLNLERSHAQKNENARQQLER 1785

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEK 178
            QN EL+ K  E E    T + K+K      E  + + +  + N  +E     K+  R EK
Sbjct: 1786 QNKELKVKLQEMEG---TVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK 1842

Query: 179  TLQEAL-----EKHQREKNEMESHIRETALEEFRLQEEQWEAE-------RRELQFIVQE 226
             L++ L     E+   E+ + ++    T L++ + Q E+ E E       RR+LQ  +++
Sbjct: 1843 KLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELED 1902

Query: 227  QDTAVQNMHKKVEKLETE 244
                   M+++V  L+ +
Sbjct: 1903 ATETADAMNREVSSLKNK 1920



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 59/324 (18%), Positives = 123/324 (37%), Gaps = 37/324 (11%)

Query: 973  QKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITH 1032
            +++++   ++  AAE     +    ++      +++++L     L  +  E +       
Sbjct: 851  EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKK 910

Query: 1033 EKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLS 1092
            ++ E  C +L   +  EE+    L  + +++Q+   +LE    EE    Q L +  K  +
Sbjct: 911  QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL-QLEKVTT 969

Query: 1093 EAKMELRRKDQ-------------------SLRQLNRHLTQLEQDKRRL-------EENI 1126
            EAK++   ++Q                    + +   +LT+ E+  + L       E  I
Sbjct: 970  EAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI 1029

Query: 1127 HDAESALRMAAKDKECVANHMRAVENTLHKVRDQIS--------LSWSAASRNDFTLQLP 1178
             D E  LR   K ++ +    R +E     + DQI+        L    A + +  LQ  
Sbjct: 1030 TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE-ELQAA 1088

Query: 1179 KLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKSEL 1238
               +E  A +      ++   ++ I    +  +         EK+       + ALK+EL
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148

Query: 1239 HTACLRENASLQSIGSRDHSNLSI 1262
                L   A+ Q + S+    ++I
Sbjct: 1149 EDT-LDSTAAQQELRSKREQEVNI 1171


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  125 bits (315), Expect = 2e-28
 Identities = 232/1193 (19%), Positives = 482/1193 (40%), Gaps = 177/1193 (14%)

Query: 13   QRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRS 72
            +R + A  ++K++ +  ++L    NL ++   A+ E      +    LA+ + ++ ++  
Sbjct: 866  ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925

Query: 73   EVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEK 132
            E+E      +     L   RK+        EE+L E    ++KL  +    +AK      
Sbjct: 926  EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK------ 979

Query: 133  AFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQ---R 189
                         ++ E ++   D+     ++E  LL +  S L   L E  EK +   +
Sbjct: 980  ------------IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027

Query: 190  EKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCS 249
             KN+ ES I E    E RL++E  E  R+EL+ + ++ +    + H+++  L+ +  +  
Sbjct: 1028 LKNKHESMISEL---EVRLKKE--EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082

Query: 250  DLLRRQTSELEFSTQR--EERLRKEFEATTLR-----VRKLEENIEAERAAHLESKFNS- 301
              L ++  EL+ +  R  +E  +K      +R     +  L+E++++ERAA  +++    
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142

Query: 302  ------EIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFA 355
                  E ++  + D   +   ++  +A+   ++ ++K    E     E   H AQ    
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-----ETRSHEAQ---- 1193

Query: 356  KLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVM---AKKHQAF 412
             +  + +++    ++L E +E+ K+   +L K  Q  EK  ++L  EL +   AK+    
Sbjct: 1194 -VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252

Query: 413  LVETCENNVKELES-ILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLED 471
              +  E  V+EL+S   D      +    +HK +++  S + +L             +  
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312

Query: 472  ASNEEKACNEL--DSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKV 529
             S++ +   EL  + T+QK++  TK +++L+++   +  +L        + E  ISTL +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1371

Query: 530  ELQNVLHCWEKEKAQAAQSESE-LQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPE 588
            +L +      K+K Q   S  E L++  + F K+ E     L   Y+   A    +++ +
Sbjct: 1372 QLSD-----SKKKLQDFASTVEALEEGKKRFQKEIEN----LTQQYEEKAAAYDKLEKTK 1422

Query: 589  GMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTK 648
                          LQ+ +D L+ DL+   + + +LE     K     +L   +++  +K
Sbjct: 1423 NR------------LQQELDDLVVDLDNQRQLVSNLE----KKQRKFDQLLAEEKNISSK 1466

Query: 649  VA-EQIKAQESCWHRQKKELELQYS-ELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQL 706
             A E+ +A+     ++ K L L  + E  LE ++  ++  ++ +  ME L   +    + 
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526

Query: 707  VLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFK 766
            V E    K+ L +TQ E+M                        TQ + L++++   E  K
Sbjct: 1527 VHELEKSKRAL-ETQMEEM-----------------------KTQLEELEDELQATEDAK 1562

Query: 767  LEIRTLAQAL---------STVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKIL 817
            L +    QAL         +  E+ +++  +++++  +    +  +     LAA   K L
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622

Query: 818  GQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAII 877
                  L    +S  +G                 +   +QLR LQA       D    + 
Sbjct: 1623 EGDLKDLELQADSAIKG----------------REEAIKQLRKLQA----QMKDFQRELE 1662

Query: 878  SSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKD 937
             + A   ++   A  N +         AK+  A LM    L  +      +R    +EK+
Sbjct: 1663 DARASRDEIFATAKENEK--------KAKSLEADLM---QLQEDLAAAERARKQADLEKE 1711

Query: 938  SLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEV 997
             L + LA  L   N L                  L+ +I    + L   +    ++   V
Sbjct: 1712 ELAEELASSLSGRNAL------------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759

Query: 998  TEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLN 1057
             +  +   ++  EL   +    +    +Q     +++  S   E+  A+  + ++ +   
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819

Query: 1058 EQAQQLQELNYKLELHSSEEADKNQTLGEAVKSL--------SEAKMELRRKDQS----- 1104
            E   ++ +L  ++E  + E+    ++L +  K L         E KM  + K+Q+     
Sbjct: 1820 E--AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877

Query: 1105 -LRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHK 1156
             ++QL R L + E++ +R+  N    +  L  A +  E +   + A+++ L +
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930



 Score =  121 bits (303), Expect = 5e-27
 Identities = 234/1200 (19%), Positives = 485/1200 (40%), Gaps = 162/1200 (13%)

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEK 178
            Q  E+QAK +E         QK KE  ++ E++L+E +        E +LL ++     +
Sbjct: 850  QEEEMQAKEDEL--------QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901

Query: 179  TLQEALEKHQR---EKNEMES--HIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQN 233
               EA E   R   +K E+E   H  E  LEE   + +Q +AER+++   + + +  ++ 
Sbjct: 902  LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961

Query: 234  MHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENI--EAER 291
                 +KL+ E +     +++   E+     +  +L KE +    R+  L  N+  E E+
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021

Query: 292  AAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQ 351
            A +L    N    +  I +LE  L+ E+ S+ E    LE +K + +   S +  +  + Q
Sbjct: 1022 AKNLTKLKNKH--ESMISELEVRLKKEEKSRQE----LEKLKRKLEGDASDFHEQIADLQ 1075

Query: 352  ESFAKLNL----LEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEEL---- 403
               A+L +     E+E  +   +L+++I ++   +    K+++  E   S+LQE+L    
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSER 1131

Query: 404  ---VMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRR 460
                 A+K +  L E  E    ELE  LDS     +  +   ++          +  L++
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE----------VTVLKK 1181

Query: 461  TLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADR 520
             L +     E  S+E +         Q ++  T+ +++ +   A+++K    L  + AD 
Sbjct: 1182 ALDE-----ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236

Query: 521  EALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAG 580
               +  L    Q V H  +K +AQ  + +S+     +A   +  +K   +H L   + + 
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA-RAELNDK---VHKLQNEVESV 1292

Query: 581  CVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQ 640
              ++ + EG   K         L ++V +L + L    E ++       N S  +R+L++
Sbjct: 1293 TGMLNEAEGKAIK---------LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1343

Query: 641  TQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAE---KNMEKLN 697
             +     ++ E+++A+++   R    L +Q S+   ++Q  A   + + E   +  +++ 
Sbjct: 1344 ERNSLQDQLDEEMEAKQNL-ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402

Query: 698  HIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDF--- 754
            ++ + +E+        +K  ++ Q+E   L+                   L  QR     
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV-----------------DLDNQRQLVSN 1445

Query: 755  LQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRL 814
            L+++   F+    E + ++   +   ++ + EA+ K+     L R   +   A+ A   L
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE---ALEAKEEL 1502

Query: 815  KILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLA 874
            +   +   +    + S K+ +G  V   E +   +  + Q E+++               
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNV--HELEKSKRALETQMEEMK--------------- 1545

Query: 875  AIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSI--- 931
               + + EL+D + +A  ++++   + + A K  F + +       E       R +   
Sbjct: 1546 ---TQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 932  -TYVEKDSLVQRLA-------HGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRL 983
             T +E +   + LA        G  K   L     ++G     K    LQ Q+  F + L
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661

Query: 984  HAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELN 1043
              A   R  +     E ++    ++ +L       MQL E   +     ++ +   EEL 
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADL-------MQLQEDLAAAERARKQADLEKEELA 1714

Query: 1044 NALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRK-- 1101
              L      +  L ++ ++L+    +LE    EE    + + + V+  ++   +L  +  
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774

Query: 1102 -DQSLRQLNRHL-TQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRD 1159
             ++S  Q N     QLE+  + L   +H+ E A++  +K K  +A    A+E  + ++ +
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVK--SKFKSTIA----ALEAKIAQLEE 1828

Query: 1160 QI------------SLSWSAASRNDFTLQL--PKLHLETFAMEGLKGGPEVVACQAMIKS 1205
            Q+            SL        +  LQ+   +   E +  +  KG   V   +  ++ 
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888

Query: 1206 FMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTACLRENASLQSIGSRDHSNLSIPSR 1265
              +  Q  +     L++E+           +E + A  RE  +L+S   R +    +PSR
Sbjct: 1889 AEEESQRINANRRKLQRELDE--------ATESNEAMGREVNALKSKLRRGNETSFVPSR 1940



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 60/258 (23%), Positives = 112/258 (43%), Gaps = 26/258 (10%)

Query: 9    TGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTK----HNA---ELA 61
            T      K  SL+   +++ + +L   +  RK+    K+E  E         NA   E  
Sbjct: 1674 TAKENEKKAKSLEA-DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1732

Query: 62   SYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAG-LGRRAAEERLA--EAHRIQEKLCA 118
              E++IA+L  E+E+ +   +++   +  A ++A  L    A ER    +    +++L  
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEK 178
            QN EL++K +E E A ++   K+K      E  + + +  ++   RE     K   + +K
Sbjct: 1793 QNKELRSKLHEMEGAVKS---KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849

Query: 179  TLQEAL------------EKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQE 226
             L+E L             K Q EK        +  LEE   + ++  A RR+LQ  + E
Sbjct: 1850 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909

Query: 227  QDTAVQNMHKKVEKLETE 244
               + + M ++V  L+++
Sbjct: 1910 ATESNEAMGREVNALKSK 1927



 Score = 30.8 bits (68), Expect = 9.0
 Identities = 21/86 (24%), Positives = 38/86 (44%), Gaps = 3/86 (3%)

Query: 1048 REEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQ 1107
            R+E+      ++ Q+ +E   K E    E   K+  L E    L E   +L+ + +   +
Sbjct: 849  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE---QLQAETELYAE 905

Query: 1108 LNRHLTQLEQDKRRLEENIHDAESAL 1133
                  +L   K+ LEE +H+ E+ L
Sbjct: 906  AEEMRVRLAAKKQELEEILHEMEARL 931


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  125 bits (315), Expect = 2e-28
 Identities = 232/1193 (19%), Positives = 482/1193 (40%), Gaps = 177/1193 (14%)

Query: 13   QRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRS 72
            +R + A  ++K++ +  ++L    NL ++   A+ E      +    LA+ + ++ ++  
Sbjct: 873  ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 932

Query: 73   EVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEK 132
            E+E      +     L   RK+        EE+L E    ++KL  +    +AK      
Sbjct: 933  EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK------ 986

Query: 133  AFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQ---R 189
                         ++ E ++   D+     ++E  LL +  S L   L E  EK +   +
Sbjct: 987  ------------IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034

Query: 190  EKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCS 249
             KN+ ES I E    E RL++E  E  R+EL+ + ++ +    + H+++  L+ +  +  
Sbjct: 1035 LKNKHESMISEL---EVRLKKE--EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089

Query: 250  DLLRRQTSELEFSTQR--EERLRKEFEATTLR-----VRKLEENIEAERAAHLESKFNS- 301
              L ++  EL+ +  R  +E  +K      +R     +  L+E++++ERAA  +++    
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149

Query: 302  ------EIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFA 355
                  E ++  + D   +   ++  +A+   ++ ++K    E     E   H AQ    
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-----ETRSHEAQ---- 1200

Query: 356  KLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVM---AKKHQAF 412
             +  + +++    ++L E +E+ K+   +L K  Q  EK  ++L  EL +   AK+    
Sbjct: 1201 -VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259

Query: 413  LVETCENNVKELES-ILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLED 471
              +  E  V+EL+S   D      +    +HK +++  S + +L             +  
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319

Query: 472  ASNEEKACNEL--DSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKV 529
             S++ +   EL  + T+QK++  TK +++L+++   +  +L        + E  ISTL +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1378

Query: 530  ELQNVLHCWEKEKAQAAQSESE-LQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPE 588
            +L +      K+K Q   S  E L++  + F K+ E     L   Y+   A    +++ +
Sbjct: 1379 QLSD-----SKKKLQDFASTVEALEEGKKRFQKEIEN----LTQQYEEKAAAYDKLEKTK 1429

Query: 589  GMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTK 648
                          LQ+ +D L+ DL+   + + +LE     K     +L   +++  +K
Sbjct: 1430 NR------------LQQELDDLVVDLDNQRQLVSNLE----KKQRKFDQLLAEEKNISSK 1473

Query: 649  VA-EQIKAQESCWHRQKKELELQYS-ELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQL 706
             A E+ +A+     ++ K L L  + E  LE ++  ++  ++ +  ME L   +    + 
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533

Query: 707  VLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFK 766
            V E    K+ L +TQ E+M                        TQ + L++++   E  K
Sbjct: 1534 VHELEKSKRAL-ETQMEEM-----------------------KTQLEELEDELQATEDAK 1569

Query: 767  LEIRTLAQAL---------STVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKIL 817
            L +    QAL         +  E+ +++  +++++  +    +  +     LAA   K L
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629

Query: 818  GQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAII 877
                  L    +S  +G                 +   +QLR LQA       D    + 
Sbjct: 1630 EGDLKDLELQADSAIKG----------------REEAIKQLRKLQA----QMKDFQRELE 1669

Query: 878  SSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKD 937
             + A   ++   A  N +         AK+  A LM    L  +      +R    +EK+
Sbjct: 1670 DARASRDEIFATAKENEK--------KAKSLEADLM---QLQEDLAAAERARKQADLEKE 1718

Query: 938  SLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEV 997
             L + LA  L   N L                  L+ +I    + L   +    ++   V
Sbjct: 1719 ELAEELASSLSGRNAL------------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766

Query: 998  TEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLN 1057
             +  +   ++  EL   +    +    +Q     +++  S   E+  A+  + ++ +   
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826

Query: 1058 EQAQQLQELNYKLELHSSEEADKNQTLGEAVKSL--------SEAKMELRRKDQS----- 1104
            E   ++ +L  ++E  + E+    ++L +  K L         E KM  + K+Q+     
Sbjct: 1827 E--AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884

Query: 1105 -LRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHK 1156
             ++QL R L + E++ +R+  N    +  L  A +  E +   + A+++ L +
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937



 Score =  121 bits (303), Expect = 5e-27
 Identities = 234/1200 (19%), Positives = 485/1200 (40%), Gaps = 162/1200 (13%)

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEK 178
            Q  E+QAK +E         QK KE  ++ E++L+E +        E +LL ++     +
Sbjct: 857  QEEEMQAKEDEL--------QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908

Query: 179  TLQEALEKHQR---EKNEMES--HIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQN 233
               EA E   R   +K E+E   H  E  LEE   + +Q +AER+++   + + +  ++ 
Sbjct: 909  LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 234  MHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENI--EAER 291
                 +KL+ E +     +++   E+     +  +L KE +    R+  L  N+  E E+
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028

Query: 292  AAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQ 351
            A +L    N    +  I +LE  L+ E+ S+ E    LE +K + +   S +  +  + Q
Sbjct: 1029 AKNLTKLKNKH--ESMISELEVRLKKEEKSRQE----LEKLKRKLEGDASDFHEQIADLQ 1082

Query: 352  ESFAKLNL----LEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEEL---- 403
               A+L +     E+E  +   +L+++I ++   +    K+++  E   S+LQE+L    
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSER 1138

Query: 404  ---VMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRR 460
                 A+K +  L E  E    ELE  LDS     +  +   ++          +  L++
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE----------VTVLKK 1188

Query: 461  TLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADR 520
             L +     E  S+E +         Q ++  T+ +++ +   A+++K    L  + AD 
Sbjct: 1189 ALDE-----ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243

Query: 521  EALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAG 580
               +  L    Q V H  +K +AQ  + +S+     +A   +  +K   +H L   + + 
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA-RAELNDK---VHKLQNEVESV 1299

Query: 581  CVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQ 640
              ++ + EG   K         L ++V +L + L    E ++       N S  +R+L++
Sbjct: 1300 TGMLNEAEGKAIK---------LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1350

Query: 641  TQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAE---KNMEKLN 697
             +     ++ E+++A+++   R    L +Q S+   ++Q  A   + + E   +  +++ 
Sbjct: 1351 ERNSLQDQLDEEMEAKQNL-ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409

Query: 698  HIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDF--- 754
            ++ + +E+        +K  ++ Q+E   L+                   L  QR     
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV-----------------DLDNQRQLVSN 1452

Query: 755  LQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRL 814
            L+++   F+    E + ++   +   ++ + EA+ K+     L R   +   A+ A   L
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE---ALEAKEEL 1509

Query: 815  KILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLA 874
            +   +   +    + S K+ +G  V   E +   +  + Q E+++               
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNV--HELEKSKRALETQMEEMK--------------- 1552

Query: 875  AIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSI--- 931
               + + EL+D + +A  ++++   + + A K  F + +       E       R +   
Sbjct: 1553 ---TQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 932  -TYVEKDSLVQRLA-------HGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRL 983
             T +E +   + LA        G  K   L     ++G     K    LQ Q+  F + L
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668

Query: 984  HAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELN 1043
              A   R  +     E ++    ++ +L       MQL E   +     ++ +   EEL 
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADL-------MQLQEDLAAAERARKQADLEKEELA 1721

Query: 1044 NALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRK-- 1101
              L      +  L ++ ++L+    +LE    EE    + + + V+  ++   +L  +  
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781

Query: 1102 -DQSLRQLNRHL-TQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRD 1159
             ++S  Q N     QLE+  + L   +H+ E A++  +K K  +A    A+E  + ++ +
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVK--SKFKSTIA----ALEAKIAQLEE 1835

Query: 1160 QI------------SLSWSAASRNDFTLQL--PKLHLETFAMEGLKGGPEVVACQAMIKS 1205
            Q+            SL        +  LQ+   +   E +  +  KG   V   +  ++ 
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895

Query: 1206 FMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTACLRENASLQSIGSRDHSNLSIPSR 1265
              +  Q  +     L++E+           +E + A  RE  +L+S   R +    +PSR
Sbjct: 1896 AEEESQRINANRRKLQRELDE--------ATESNEAMGREVNALKSKLRRGNETSFVPSR 1947



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 60/258 (23%), Positives = 112/258 (43%), Gaps = 26/258 (10%)

Query: 9    TGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTK----HNA---ELA 61
            T      K  SL+   +++ + +L   +  RK+    K+E  E         NA   E  
Sbjct: 1681 TAKENEKKAKSLEA-DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1739

Query: 62   SYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAG-LGRRAAEERLA--EAHRIQEKLCA 118
              E++IA+L  E+E+ +   +++   +  A ++A  L    A ER    +    +++L  
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEK 178
            QN EL++K +E E A ++   K+K      E  + + +  ++   RE     K   + +K
Sbjct: 1800 QNKELRSKLHEMEGAVKS---KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856

Query: 179  TLQEAL------------EKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQE 226
             L+E L             K Q EK        +  LEE   + ++  A RR+LQ  + E
Sbjct: 1857 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916

Query: 227  QDTAVQNMHKKVEKLETE 244
               + + M ++V  L+++
Sbjct: 1917 ATESNEAMGREVNALKSK 1934



 Score = 30.8 bits (68), Expect = 9.0
 Identities = 21/86 (24%), Positives = 38/86 (44%), Gaps = 3/86 (3%)

Query: 1048 REEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQ 1107
            R+E+      ++ Q+ +E   K E    E   K+  L E    L E   +L+ + +   +
Sbjct: 856  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE---QLQAETELYAE 912

Query: 1108 LNRHLTQLEQDKRRLEENIHDAESAL 1133
                  +L   K+ LEE +H+ E+ L
Sbjct: 913  AEEMRVRLAAKKQELEEILHEMEARL 938


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  125 bits (314), Expect = 3e-28
 Identities = 190/876 (21%), Positives = 374/876 (42%), Gaps = 133/876 (15%)

Query: 11   DTQRLKIASLDVK-QI--LKNETELDI--TDNLRKKLHWAKKEKLEITTKHNA------- 58
            D+Q L +   +++ QI  L  E EL +  +++L+ +L  +  EKL ++    A       
Sbjct: 2043 DSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGE 2102

Query: 59   ---ELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEK 115
                L+S + ++ +LR  +EK   LR  +E D    +K+  +  +  +ER  E   +++K
Sbjct: 2103 FALRLSSTQEEVHQLRRGIEK---LRVRIEAD---EKKQLHIAEKL-KERERENDSLKDK 2155

Query: 116  LCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSR 175
            +     ELQ      E     ++   K E    +  +EE    ++    +   L  EK  
Sbjct: 2156 VENLERELQMSEENQELVILDAENS-KAEVETLKTQIEEMARSLKVFELDLVTLRSEKEN 2214

Query: 176  LEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMH 235
            L K +QE     Q + +E++       L  F+   E  E E+ E+Q I +E  TAV+ + 
Sbjct: 2215 LTKQIQEK----QGQLSELDK-----LLSSFKSLLE--EKEQAEIQ-IKEESKTAVEMLQ 2262

Query: 236  KKVEKL-ETEHMDCSD--LLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERA 292
             ++++L E     C D  +++     L+   + E +LR   E       KL   +EA+  
Sbjct: 2263 NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE-------KLRARLEADEK 2315

Query: 293  AHL-------ESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYER 345
              L       ES+ ++++++ R+ +LE  L++ + +Q  A  + E  K E + +++  E 
Sbjct: 2316 KQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIE- 2374

Query: 346  EKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVM 405
                  +S   L L      S+ + L  +++++++ I +L       E    E ++E V 
Sbjct: 2375 ---GMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQ 2431

Query: 406  AKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKD----KPPSFSVVLERLRRT 461
             K+  +  +E  +  +KEL           +  + +H D++    K  + S  +E L   
Sbjct: 2432 MKEKSSTAMEMLQTQLKELN----------ERVAALHNDQEACKAKEQNLSSQVECLELE 2481

Query: 462  LTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADRE 521
                   L++A N           +  ++   + +++ + KL   ++E+S L  +  D+E
Sbjct: 2482 KAQLLQGLDEAKNNYIVL------QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQE 2535

Query: 522  ALISTLKVELQNVLHCWEKEKAQAAQSESELQK---LSQAFHKDAEEKLTFLHTLYQHLV 578
             L+S L  +++     W+++  +      EL++   + Q+ +   ++ L  L + Y++L 
Sbjct: 2536 QLVSKLS-QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLE 2594

Query: 579  AGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHL-EYICKNKSDTMRE 637
                L K     +DK S+ E    +      L  +++   +K   L E +   K+    E
Sbjct: 2595 NELELTK-----MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGE 2649

Query: 638  LQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFL--------EVQKRAQKFQEIA 689
            LQ         + E+IK+ +     Q KEL L+ SEL          +V+K  +  +EIA
Sbjct: 2650 LQL--------LLEEIKSSKD----QLKELTLENSELKKSLDCMHKDQVEKEGKVREEIA 2697

Query: 690  EKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALS 749
            E  + +L+  EK H+ L+L+ +   ++  QT RE+                       L+
Sbjct: 2698 EYQL-RLHEAEKKHQALLLDTNKQYEVEIQTYREK-----------------------LT 2733

Query: 750  TQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVL 809
            ++ + L  Q    +L K     L  +L    +  +E  K K    K + ++ ++      
Sbjct: 2734 SKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKEN---ER 2790

Query: 810  AANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQ 845
            A  ++K+L +SC  L    E  ++ +  L    E Q
Sbjct: 2791 AQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ 2826



 Score =  108 bits (269), Expect = 4e-23
 Identities = 239/1215 (19%), Positives = 495/1215 (40%), Gaps = 210/1215 (17%)

Query: 30   TELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLA 89
            T+++    L K +   KKE  +++ K    L  +     +L   VE  E L   LE    
Sbjct: 1820 TKIEACIELEKIVGELKKENSDLSEK----LEYFSCDHQELLQRVETSEGLNSDLEMHAD 1875

Query: 90   VARKEAGLGRRAAE------ERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKE 143
             + +E  +G   A+      ER  +      ++ ++ + ++ +    E   +  Q +  +
Sbjct: 1876 KSSRE-DIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTE--K 1932

Query: 144  ECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETAL 203
             C   E D E +  +I     E  ++  E+++L   L + + K     +++   ++E   
Sbjct: 1933 LC--LEKDNENKQKVIVCLEEELSVVTSERNQLRGEL-DTMSKKTTALDQLSEKMKE--- 1986

Query: 204  EEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFST 263
                 + ++ E+ + E    +Q  +  V+   +K E L+T   D S+LL+ +T   E   
Sbjct: 1987 -----KTQELESHQSECLHCIQVAEAEVK---EKTELLQTLSSDVSELLKDKTHLQE--- 2035

Query: 264  QREERLRKEFEATTLRVRKLEENI-EAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQ 322
             + + L K+ +A +L   +LE  I +  +   L  K  SE +Q R+ + +     EK + 
Sbjct: 2036 -KLQSLEKDSQALSLTKCELENQIAQLNKEKELLVK-ESESLQARLSESD----YEKLNV 2089

Query: 323  AEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVI 382
            ++A+    + K EF    S+ + E H  +    KL +  +    K   + E ++E+++  
Sbjct: 2090 SKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREN 2149

Query: 383  IDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIH 442
              L  +++        L+ EL M++++Q  ++   EN+  E+E++               
Sbjct: 2150 DSLKDKVE-------NLERELQMSEENQELVILDAENSKAEVETL--------------- 2187

Query: 443  KDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDK 502
                        +E + R+L  ++  L    +E+             ++ TK I+E Q +
Sbjct: 2188 ---------KTQIEEMARSLKVFELDLVTLRSEK-------------ENLTKQIQEKQGQ 2225

Query: 503  LADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESEL---QKLSQAF 559
            L++++K LS   +   ++E     +K E +  +   + +  +  ++ + L   Q++ +A 
Sbjct: 2226 LSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKAT 2285

Query: 560  HKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADL--NRA 617
             +  +  +   H L          I++    L+     +LC + Q       ADL   R 
Sbjct: 2286 EQSLDPPIEEEHQLRNS-------IEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRV 2338

Query: 618  NEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLE 677
                R LE    N+     E + ++ +      E +KA+     +  + LEL    +  E
Sbjct: 2339 ENLERELEIARTNQEHAALEAENSKGEV-----ETLKAKIEGMTQSLRGLELDVVTIRSE 2393

Query: 678  VQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLL----AACAL 733
             +    + Q    K  E+++ +E       + NS F+ +L + ++E++ +      A  +
Sbjct: 2394 KENLTNELQ----KEQERISELE-------IINSSFENILQEKEQEKVQMKEKSSTAMEM 2442

Query: 734  MAGALYPLYSRSCALSTQRDF-------LQEQVNTFELFKLEIRTLAQALSTVEEKKQEE 786
            +   L  L  R  AL   ++        L  QV   EL K      AQ L  ++E K   
Sbjct: 2443 LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK------AQLLQGLDEAKNNY 2496

Query: 787  AKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQD 846
              ++     GLI+    G        +L+   +  + L   ++  ++ +  L    + + 
Sbjct: 2497 IVLQSSV-NGLIQEVEDG------KQKLEKKDEEISRLKNQIQDQEQLVSKL---SQVEG 2546

Query: 847  KHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAK 906
            +H+  K Q  +LR L     +     +  + S  A LQD +            +L  + K
Sbjct: 2547 EHQLWKEQNLELRNLT----VELEQKIQVLQSKNASLQDTL-----------EVLQSSYK 2591

Query: 907  NSFAKL----MDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGH 962
            N   +L    MDK+S V +   + +  +    E   + Q+ A    +++    K  L G 
Sbjct: 2592 NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELS--GEKNRLAGE 2649

Query: 963  VPIT----KSTASLQKQILGFTQRL-------HAAEVERRS-LRLEVTEFKRSVNEMKKE 1010
            + +     KS+    K++      L       H  +VE+   +R E+ E++  ++E +K+
Sbjct: 2650 LQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKK 2709

Query: 1011 -----LDKAQGLQMQLNEFKQS-----KLITHEKFE-----SACEELNNALLREEQAQML 1055
                 LD  +  ++++  +++      + ++ +K E     S+ EELNN+L  +   Q+L
Sbjct: 2710 HQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSL--KATTQIL 2767

Query: 1056 LNEQAQQLQELNYKLELHSSEE--ADKNQTLGEAVKSLSEAKMELRRKDQSLR------- 1106
               +  ++  L Y  +L    E    K + L ++ K L E K  L+++   L+       
Sbjct: 2768 EELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQK 2827

Query: 1107 -------QLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKEC--VANHMRAVENTLHKV 1157
                   +++   T++++ K  LEE   +A+  L     DK C  + +H + +E     +
Sbjct: 2828 TGTVMDTKVDELTTEIKELKETLEEKTKEADEYL-----DKYCSLLISHEK-LEKAKEML 2881

Query: 1158 RDQISLSWSAASRND 1172
              Q++   S  S+ D
Sbjct: 2882 ETQVAHLCSQQSKQD 2896



 Score =  100 bits (249), Expect = 9e-21
 Identities = 209/1121 (18%), Positives = 429/1121 (38%), Gaps = 175/1121 (15%)

Query: 85   EYDLAVARKEAGLGRRAAEERL---AEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKW 141
            E ++  +R    +G+R A       + +  + ++L AQN EL+ K NE E   Q  +++ 
Sbjct: 249  EQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEM 308

Query: 142  KEECRRFEH----------DLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREK 191
            K +  +F+           +L E++ ++  C  E   L++  ++ ++   +     Q+ K
Sbjct: 309  KGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDE---LVRTTAQYDQASTKYTALEQKLK 365

Query: 192  NEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQN-MHKKVEKLETEHMDCSD 250
                        E+   Q +  E+ R  L+  ++E++   Q  + ++    +T   +C  
Sbjct: 366  K---------LTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQ 416

Query: 251  LLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIE--AERAAHLESKFNSEII---Q 305
            +  R T EL+ +      L+ E +  T   ++LE N+E   ++    E  F +  I   +
Sbjct: 417  MKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENE 476

Query: 306  LR--IRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKE 363
            LR  + +++    + K+   +   ++  ++ E K ++    + ++ A+E  AK    E  
Sbjct: 477  LRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETM 536

Query: 364  YFSKNKKLNED-----IEEQKKVIIDLSKR-------LQYNEKSCSELQEELVMAKKHQA 411
                 +K+N+      +E+ K  + DL K+       L+  E    +L ++L   +K   
Sbjct: 537  LRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESK 596

Query: 412  FLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLED 471
             L+   E   KE E + +  T+   W S                E+L   +   +  L+ 
Sbjct: 597  ALLSALELKKKEYEELKEEKTLFSCWKS--------------ENEKLLTQMESEKENLQS 642

Query: 472  ASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVEL 531
              N  + C  L + + K   + + ++ L+    +++ E+ +LH     +   + T K+  
Sbjct: 643  KINHLETC--LKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAY 700

Query: 532  QNVLHCWE-KEKAQAAQSESELQKLSQAFH--KDAEEKLTFLHT-------LYQHLVAGC 581
              +    E  ++    + E+   K SQ     +D E KL  L          YQ L A  
Sbjct: 701  MELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHA-- 758

Query: 582  VLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQT 641
                + E + D     +   V  E+    +   ++          I   +     E  + 
Sbjct: 759  ----EYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSEC 814

Query: 642  QEDTFTKVAEQIKAQESCWHRQKKELEL---QYSELFLEVQKRAQKFQEIAEKNMEKLNH 698
            + +     A+Q     +    +   LE       ++  ++QK+ ++  +I  +  E L  
Sbjct: 815  RLE-----ADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMK 869

Query: 699  IEKSHEQLVLENS-HFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQE 757
             E+ H+  V E S    KL   T   Q  +    + +      L   +  + T++  +QE
Sbjct: 870  AEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQE 929

Query: 758  QVNTFELFK---LEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRL 814
               +  L +    E++ L++ LS  +++      + K+  + L +    G +  + A+  
Sbjct: 930  LKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQ--ENGTLKEINAS-- 985

Query: 815  KILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLA 874
              L Q   +L    ESF   I       E        ++++E+L  LQ      ++    
Sbjct: 986  --LNQEKMNLIQKSESFANYID----EREKSISELSDQYKQEKLILLQRCEETGNA---- 1035

Query: 875  AIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYV 934
                     +D+  K              AA+   +KL     L+ EC  L  +R     
Sbjct: 1036 --------YEDLSQK------------YKAAQEKNSKLE---CLLNECTSLCENRK---N 1069

Query: 935  EKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILG-FTQRLHAAEVERRSL 993
            E + L +  A   H+     L +    +  +     ++Q+ +    T   + ++ E   L
Sbjct: 1070 ELEQLKEAFAKE-HQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGL 1128

Query: 994  RLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQ 1053
            + E+   K   N+M+KE++      +Q NE    +L+   K +  C+ L +  +R     
Sbjct: 1129 KQEIMTLKEEQNKMQKEVNDL----LQENE----QLMKVMKTKHECQNLESEPIRNS--- 1177

Query: 1054 MLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLT 1113
              + E+  +  + N+K                         +M+L  K+ SL   N  L 
Sbjct: 1178 --VKERESERNQCNFK------------------------PQMDLEVKEISLDSYNAQLV 1211

Query: 1114 QLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTL 1154
            QLE   R  E  + ++E       K+KEC+ + ++ +   L
Sbjct: 1212 QLEAMLRNKELKLQESE-------KEKECLQHELQTIRGDL 1245



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 255/1266 (20%), Positives = 505/1266 (39%), Gaps = 188/1266 (14%)

Query: 89   AVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRF 148
            A+   + GL  RA + ++ E     +KL  +  + Q + +  E A Q  +QK        
Sbjct: 4    ALEEWKEGLPTRALQ-KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQK-------- 54

Query: 149  EHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRL 208
               +E       N  RE   LM+    LEKT Q+    H+ +  E + + +E  L   + 
Sbjct: 55   ---VENEKTEGTNLKRENQRLMEICESLEKTKQKI--SHELQVKESQVNFQEGQLNSGKK 109

Query: 209  QEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLL---------RRQTSEL 259
            Q E+ E E +  +  ++    A Q+    +    T     +  L         + +  + 
Sbjct: 110  QIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKE 169

Query: 260  EFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEK 319
            +++ + EER R E E   L+ +K  + +      H       +I + +      + Q EK
Sbjct: 170  KYNKEVEERKRLEAEVKALQAKKASQTLPQATMNH------RDIARHQASSSVFSWQQEK 223

Query: 320  A-SQAEAVADLEIIKNEFKEVESAYERE-----------KHNAQESFAKLNLLEKEYFSK 367
              S   + +    I+ +F     + E+E           K +A  SF   N        +
Sbjct: 224  TPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFD-NSSSPHLLDQ 282

Query: 368  NKKLNEDIEEQKKVIIDLSKRLQYNEK----SCSELQEELVMAKKHQAFLVETCENNVKE 423
             K  N+++  +   I +L  RLQ +EK      ++ QE  +  +K +  L+E      K 
Sbjct: 283  LKAQNQELRNK---INELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIE----KEKV 335

Query: 424  LESILDSFT-VSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNEL 482
            L    D     + Q+     K       ++ + ++L++   D   + ++A  E   C   
Sbjct: 336  LNKCRDELVRTTAQYDQASTK-------YTALEQKLKKLTEDLSCQRQNA--ESARC--- 383

Query: 483  DSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEK 542
             S +QKI    +  KE Q++L+   +    L  +C   +A ++    + +N+ +  + E 
Sbjct: 384  -SLEQKI---KEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAEL 439

Query: 543  AQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPE---GMLDKFSWSEL 599
             +    + +L+   + F    ++KL      +Q        IK+ E    M +    + L
Sbjct: 440  DKLTSVKQQLENNLEEF----KQKLCRAEQAFQ-----ASQIKENELRRSMEEMKKENNL 490

Query: 600  CAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESC 659
                 E     +  L    + I+      +N ++ M+    +QE     + E+I  QE+ 
Sbjct: 491  LKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENS 550

Query: 660  WHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQ 719
               +K +L +       +++K+    Q++ +K   + +HIE+ +++           LS+
Sbjct: 551  LTLEKLKLAV------ADLEKQRDCSQDLLKK---REHHIEQLNDK-----------LSK 590

Query: 720  TQREQMSLLAACALMAGALYPLYSR----SCALSTQRDFLQEQVNTFELFKLEIRTLAQA 775
            T++E  +LL+A  L       L       SC  S     L +  +  E  + +I  L   
Sbjct: 591  TEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETC 650

Query: 776  LSTVEEKKQE--EAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASL-------FT 826
            L T + K  E  E     +  +  + +  + +  VL +  +++  Q  A +       F+
Sbjct: 651  LKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFS 710

Query: 827  WMESFKEGIGMLV----CTGEPQD-KHKFPKHQKEQL---RCLQAL--SWLTSSDLLAAI 876
              +  KE   M +     TG+ +D +HK      E +   RC Q L   + +  DLL + 
Sbjct: 711  DQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK 770

Query: 877  ISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEK 936
             +S+      +   D    +       A  +SFA      +++ E   + S RS   +E 
Sbjct: 771  DASL------VTNEDHQRSLLAFDQQPAMHHSFA------NIIGEQGSMPSERSECRLEA 818

Query: 937  DSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLE 996
            D   +  A   ++V+  +L++ L       +  + LQKQ     Q     E+E   ++ E
Sbjct: 819  DQSPKNSAILQNRVD--SLEFSLESQ---KQMNSDLQKQCEELVQ--IKGEIEENLMKAE 871

Query: 997  ------VTEFKRSVNEMKKELDKAQGL---QMQLNEFKQSKL-ITHEKFESACEEL---- 1042
                  V E  + +++++++    Q +    +   E K+ +L + ++K E+   E+    
Sbjct: 872  QMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELK 931

Query: 1043 -NNALLRE--EQAQMLLNEQAQQLQELNYKLELHS---SEEADKNQTLGEAVKSLSEAKM 1096
             +N LL +  ++ Q+L    + + +E++  + L+     E   +N TL E   SL++ KM
Sbjct: 932  KSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKM 991

Query: 1097 ELRRKDQSL--------RQLNRHLTQLEQDK----RRLEE--NIHDAESALRMAAKDK-- 1140
             L +K +S         + ++    Q +Q+K    +R EE  N ++  S    AA++K  
Sbjct: 992  NLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNS 1051

Query: 1141 --ECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGPEVVA 1198
              EC+ N   ++        +Q+  ++ A    +F   L KL       + L    E V 
Sbjct: 1052 KLECLLNECTSLCENRKNELEQLKEAF-AKEHQEF---LTKLAFAEERNQNLMLELETVQ 1107

Query: 1199 CQAMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTACLRENASLQSIGSRDHS 1258
             QA+     D    + +    L++E+ + +     ++ E++   L+EN  L  +    H 
Sbjct: 1108 -QALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVND-LLQENEQLMKVMKTKHE 1165

Query: 1259 NLSIPS 1264
              ++ S
Sbjct: 1166 CQNLES 1171



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 262/1310 (20%), Positives = 504/1310 (38%), Gaps = 218/1310 (16%)

Query: 46   KKEKLEITTKHNAELAS----YESQIAKLRSEVEKGEALR----QSLEYDLAVARKEAGL 97
            +KE      K   EL S    Y   + KL  ++E    ++    Q LE  L+  R+E   
Sbjct: 1538 RKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDC 1597

Query: 98   GRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEH---DLEE 154
             R+   + L+E  + Q+KL +   E+++K    +K  QT Q   + E  R +    DL  
Sbjct: 1598 LRK---QYLSENEQWQQKLTSVTLEMESKLAAEKK--QTEQLSLELEVARLQLQGLDLSS 1652

Query: 155  R-------DNMIQNCNREYDLLMKEKSRL-EKTLQEALEKHQREKNEMESHIRETALEEF 206
            R       ++ IQ  N   D+  +  S   E+T +  + +   +  + + ++    + E 
Sbjct: 1653 RSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITET 1712

Query: 207  RLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQRE 266
               +   E          Q  DT   N     E       +C        SEL FS    
Sbjct: 1713 GAVKPTGECSGE------QSPDT---NYEPPGEDKTQGSSEC-------ISELSFSGPNA 1756

Query: 267  ----ERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQL--RIRDLEGAL---QV 317
                + L  + +   L++R  E + E  R  H+    + ++  L   +++L+  L   +V
Sbjct: 1757 LVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEV 1816

Query: 318  EKASQAEAVADLEIIKNEFKEVESAY-EREKHNAQESFAKLNLLE-KEYFSKNKKLNEDI 375
            +  ++ EA  +LE I  E K+  S   E+ ++ + +    L  +E  E  + + +++ D 
Sbjct: 1817 QLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADK 1876

Query: 376  EEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSG 435
              ++ +  +++K     ++   +++ EL   +  +A +    E+    LE+ L+      
Sbjct: 1877 SSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASI----EHEALYLEADLEVVQTEK 1932

Query: 436  QWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLE-DASNEEKACNELDSTKQKIDSHTK 494
                 + KD +      V LE     +T  +N+L  +     K    LD   +K+   T+
Sbjct: 1933 LC---LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQ 1989

Query: 495  NIKELQDKL--------ADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAA 546
             ++  Q +         A+V ++   L T  +D   L+   K  LQ  L   EK+    +
Sbjct: 1990 ELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKD-KTHLQEKLQSLEKDSQALS 2048

Query: 547  QSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQEN 606
             ++ EL+      +K+ E                 +L+K+ E +  + S S         
Sbjct: 2049 LTKCELENQIAQLNKEKE-----------------LLVKESESLQARLSES--------- 2082

Query: 607  VDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDT------FTKVAEQIKAQESCW 660
                  D  + N   + LE     K +    L  TQE+         K+  +I+A E   
Sbjct: 2083 ------DYEKLNVS-KALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE--- 2132

Query: 661  HRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVL--ENSHFKKLLS 718
               KK+L +  +E   E ++     ++  E    +L   E++ E ++L  ENS  +    
Sbjct: 2133 ---KKQLHI--AEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETL 2187

Query: 719  QTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALST 778
            +TQ E+M    A +L    L  +  RS   +  +   ++Q    EL KL    L+   S 
Sbjct: 2188 KTQIEEM----ARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKL----LSSFKSL 2239

Query: 779  VEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGML 838
            +EEK+Q E ++K+++         K  + +L  N+LK L ++ A+L    E  K     L
Sbjct: 2240 LEEKEQAEIQIKEES---------KTAVEMLQ-NQLKELNEAVAALCGDQEIMKATEQSL 2289

Query: 839  VCTGEPQD---------KHKFPKHQKEQLRCLQALSWLTS-SDLLAAIISSMAELQDVIG 888
                E +          + +    +K+QL  LQ L      +DLL   + ++    ++  
Sbjct: 2290 DPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIAR 2349

Query: 889  KADPNSRICGHLLIGAAKNSFAKLMDKIS----LVMECIPLHSSRSITYVEKDSLVQRLA 944
                ++ +      G  +   AK+         L ++ + + S       EK++L   L 
Sbjct: 2350 TNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS-------EKENLTNELQ 2402

Query: 945  HGLHKVNTLAL-----------KYGLRGHVPITKSTAS--LQKQILGFTQRLHAAEVERR 991
                +++ L +           K   +  +    STA   LQ Q+    +R+ A   ++ 
Sbjct: 2403 KEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQE 2462

Query: 992  SLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITH-----------------EK 1034
            + + +       V  +  EL+KAQ LQ  L+E K + ++                   EK
Sbjct: 2463 ACKAKEQNLSSQVECL--ELEKAQLLQ-GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 2519

Query: 1035 FESACEELNNALLREEQA----------QMLLNEQAQQLQELNYKLELHSSEEADKNQTL 1084
             +     L N +  +EQ             L  EQ  +L+ L  +LE        KN +L
Sbjct: 2520 KDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASL 2579

Query: 1085 GEAVKSLS------EAKMELRRKDQS--LRQLNRHLTQLEQDKRRLEENIHDAESALRMA 1136
             + ++ L       E ++EL + D+   + ++N+   +  + +R + E            
Sbjct: 2580 QDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEEL 2639

Query: 1137 AKDKECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGPEV 1196
            + +K  +A  ++ +   +   +DQ  L       ++    L  +H +    EG K   E+
Sbjct: 2640 SGEKNRLAGELQLLLEEIKSSKDQ--LKELTLENSELKKSLDCMHKDQVEKEG-KVREEI 2696

Query: 1197 VACQAMIKS--------FMDVYQLASTRIMTLEKEMTSHRSHIAALKSEL 1238
               Q  +           +D  +     I T  +++TS    +++ K E+
Sbjct: 2697 AEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEI 2746



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 151/754 (20%), Positives = 271/754 (35%), Gaps = 95/754 (12%)

Query: 32   LDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVA 91
            L   +N  K+L     +K+E      AE+   +     L   +++ + L ++L  +    
Sbjct: 903  LSALENKEKELQLLN-DKVET---EQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEM 958

Query: 92   RKEAGLGRRAAEERLAE--------AHRIQEKL-CAQNSELQAK-TNETEKAFQTSQQKW 141
                 L +R  EE   E        A   QEK+   Q SE  A   +E EK+      ++
Sbjct: 959  SSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQY 1018

Query: 142  KEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRET 201
            K+E        EE  N  ++ +++Y    ++ S+LE  L E     +  KNE+E      
Sbjct: 1019 KQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAF 1078

Query: 202  ALEEFRLQEEQWEAERRELQFIVQEQDTAVQ-----------NMHKKVEKLETEHMDCSD 250
            A E      +   AE R  Q ++ E +T  Q           N   +   L+ E M   +
Sbjct: 1079 AKEHQEFLTKLAFAEERN-QNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKE 1137

Query: 251  LLRRQTSELEFSTQREERLRK----EFEATTLRVRKLEENIEAERAAHLESKFNSEIIQL 306
               +   E+    Q  E+L K    + E   L    +  +++   +   +  F  ++  L
Sbjct: 1138 EQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQM-DL 1196

Query: 307  RIRD------------LEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESF 354
             +++            LE  L+ ++    E+  + E +++E + +    E       +S 
Sbjct: 1197 EVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQ 1256

Query: 355  AKLNL------LEKEYFSKNKKLNEDIEEQKKVIIDLS---KRLQYNEKSCSELQ----- 400
                L       E++Y S   +L+    +   +   L     +L   EK C  LQ     
Sbjct: 1257 EISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYE 1316

Query: 401  ---------EELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGI-------HKD 444
                      E + A +  A  V    N VK L    DS  + G+    I         +
Sbjct: 1317 LVTELNDSRSECITATRKMAEEVGKLLNEVKILND--DSGLLHGELVEDIPGGEFGEQPN 1374

Query: 445  KDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACN-ELDSTKQKIDSHTKNIKELQDKL 503
            +  P S + +         D  N  E  +  +K         ++K  S     K L D+ 
Sbjct: 1375 EQHPVSLAPL---------DESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQH 1425

Query: 504  ADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDA 563
              ++ ++S L T     +A    L   L+N      KE  Q    E  +  LS +   D+
Sbjct: 1426 CQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEM-QLGLEEGLVPSLSSSCVPDS 1484

Query: 564  EE-----KLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSE---LCAVLQENVDALIADLN 615
                     +F   L +       L+   EG +     S     C+ LQE         +
Sbjct: 1485 SSLSSLGDSSFYRALLEQ-TGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPS 1543

Query: 616  RANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELF 675
               + +  LE +C+    ++ +L++  E       ++I+  E     +++EL+    +  
Sbjct: 1544 APAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYL 1603

Query: 676  LEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLE 709
             E ++  QK   +  +   KL   +K  EQL LE
Sbjct: 1604 SENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLE 1637



 Score = 39.7 bits (91), Expect = 0.019
 Identities = 62/297 (20%), Positives = 120/297 (40%), Gaps = 47/297 (15%)

Query: 981  QRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQL---NEFKQSKLITHEKFES 1037
            +R    E E   +R E    +     ++ +L+  Q  ++ L   NE KQ  ++  E+  S
Sbjct: 1895 ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELS 1954

Query: 1038 ACEELNNALLRE----EQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSE 1093
                  N L  E     +    L++ +++++E   +LE H SE           +  +  
Sbjct: 1955 VVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSE----------CLHCIQV 2004

Query: 1094 AKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIH--------------DAESALRMAAKD 1139
            A+ E++ K + L+ L+  +++L +DK  L+E +               + E+ +    K+
Sbjct: 2005 AEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKE 2064

Query: 1140 KECVAN-----HMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGP 1194
            KE +         R  E+   K+    +L  +   + +F L+L     E   +  L+ G 
Sbjct: 2065 KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEE---VHQLRRGI 2121

Query: 1195 EV--VACQAMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTACLRENASL 1249
            E   V  +A  K  + + +    R    E+E  S +  +  L+ EL  +   EN  L
Sbjct: 2122 EKLRVRIEADEKKQLHIAEKLKER----ERENDSLKDKVENLERELQMS--EENQEL 2172


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  125 bits (313), Expect = 4e-28
 Identities = 232/1191 (19%), Positives = 481/1191 (40%), Gaps = 177/1191 (14%)

Query: 13   QRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRS 72
            +R + A  ++K++ +  ++L    NL ++   A+ E      +    LA+ + ++ ++  
Sbjct: 873  ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 932

Query: 73   EVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEK 132
            E+E      +     L   RK+        EE+L E    ++KL  +    +AK      
Sbjct: 933  EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK------ 986

Query: 133  AFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQ---R 189
                         ++ E ++   D+     ++E  LL +  S L   L E  EK +   +
Sbjct: 987  ------------IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034

Query: 190  EKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCS 249
             KN+ ES I E    E RL++E  E  R+EL+ + ++ +    + H+++  L+ +  +  
Sbjct: 1035 LKNKHESMISEL---EVRLKKE--EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089

Query: 250  DLLRRQTSELEFSTQR--EERLRKEFEATTLR-----VRKLEENIEAERAAHLESKFNS- 301
              L ++  EL+ +  R  +E  +K      +R     +  L+E++++ERAA  +++    
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149

Query: 302  ------EIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFA 355
                  E ++  + D   +   ++  +A+   ++ ++K    E     E   H AQ    
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-----ETRSHEAQ---- 1200

Query: 356  KLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVM---AKKHQAF 412
             +  + +++    ++L E +E+ K+   +L K  Q  EK  ++L  EL +   AK+    
Sbjct: 1201 -VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259

Query: 413  LVETCENNVKELES-ILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLED 471
              +  E  V+EL+S   D      +    +HK +++  S + +L             +  
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319

Query: 472  ASNEEKACNEL--DSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKV 529
             S++ +   EL  + T+QK++  TK +++L+++   +  +L        + E  ISTL +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1378

Query: 530  ELQNVLHCWEKEKAQAAQSESE-LQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPE 588
            +L +      K+K Q   S  E L++  + F K+ E     L   Y+   A    +++ +
Sbjct: 1379 QLSD-----SKKKLQDFASTVEALEEGKKRFQKEIEN----LTQQYEEKAAAYDKLEKTK 1429

Query: 589  GMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTK 648
                          LQ+ +D L+ DL+   + + +LE     K     +L   +++  +K
Sbjct: 1430 NR------------LQQELDDLVVDLDNQRQLVSNLE----KKQRKFDQLLAEEKNISSK 1473

Query: 649  VA-EQIKAQESCWHRQKKELELQYS-ELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQL 706
             A E+ +A+     ++ K L L  + E  LE ++  ++  ++ +  ME L   +    + 
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533

Query: 707  VLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFK 766
            V E    K+ L +TQ E+M                        TQ + L++++   E  K
Sbjct: 1534 VHELEKSKRAL-ETQMEEM-----------------------KTQLEELEDELQATEDAK 1569

Query: 767  LEIRTLAQAL---------STVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKIL 817
            L +    QAL         +  E+ +++  +++++  +    +  +     LAA   K L
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629

Query: 818  GQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAII 877
                  L    +S  +G                 +   +QLR LQA       D    + 
Sbjct: 1630 EGDLKDLELQADSAIKG----------------REEAIKQLRKLQA----QMKDFQRELE 1669

Query: 878  SSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKD 937
             + A   ++   A  N +         AK+  A LM    L  +      +R    +EK+
Sbjct: 1670 DARASRDEIFATAKENEK--------KAKSLEADLM---QLQEDLAAAERARKQADLEKE 1718

Query: 938  SLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEV 997
             L + LA  L   N L                  L+ +I    + L   +    ++   V
Sbjct: 1719 ELAEELASSLSGRNAL------------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766

Query: 998  TEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLN 1057
             +  +   ++  EL   +    +    +Q     +++  S   E+  A+  + ++ +   
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826

Query: 1058 EQAQQLQELNYKLELHSSEEADKNQTLGEAVKSL--------SEAKMELRRKDQS----- 1104
            E   ++ +L  ++E  + E+    ++L +  K L         E KM  + K+Q+     
Sbjct: 1827 E--AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884

Query: 1105 -LRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTL 1154
             ++QL R L + E++ +R+  N    +  L  A +  E +   + A+++ L
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935



 Score =  119 bits (299), Expect = 1e-26
 Identities = 213/1082 (19%), Positives = 445/1082 (41%), Gaps = 140/1082 (12%)

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEK 178
            Q  E+QAK +E         QK KE  ++ E++L+E +        E +LL ++     +
Sbjct: 857  QEEEMQAKEDEL--------QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908

Query: 179  TLQEALEKHQR---EKNEMES--HIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQN 233
               EA E   R   +K E+E   H  E  LEE   + +Q +AER+++   + + +  ++ 
Sbjct: 909  LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 234  MHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENI--EAER 291
                 +KL+ E +     +++   E+     +  +L KE +    R+  L  N+  E E+
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028

Query: 292  AAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQ 351
            A +L    N    +  I +LE  L+ E+ S+ E    LE +K + +   S +  +  + Q
Sbjct: 1029 AKNLTKLKNKH--ESMISELEVRLKKEEKSRQE----LEKLKRKLEGDASDFHEQIADLQ 1082

Query: 352  ESFAKLNL----LEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEEL---- 403
               A+L +     E+E  +   +L+++I ++   +    K+++  E   S+LQE+L    
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSER 1138

Query: 404  ---VMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRR 460
                 A+K +  L E  E    ELE  LDS     +  +   ++          +  L++
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE----------VTVLKK 1188

Query: 461  TLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADR 520
             L +     E  S+E +         Q ++  T+ +++ +   A+++K    L  + AD 
Sbjct: 1189 ALDE-----ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243

Query: 521  EALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAG 580
               +  L    Q V H  +K +AQ  + +S+     +A   +  +K   +H L   + + 
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA-RAELNDK---VHKLQNEVESV 1299

Query: 581  CVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQ 640
              ++ + EG   K         L ++V +L + L    E ++       N S  +R+L++
Sbjct: 1300 TGMLNEAEGKAIK---------LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1350

Query: 641  TQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAE---KNMEKLN 697
             +     ++ E+++A+++   R    L +Q S+   ++Q  A   + + E   +  +++ 
Sbjct: 1351 ERNSLQDQLDEEMEAKQNL-ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409

Query: 698  HIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDF--- 754
            ++ + +E+        +K  ++ Q+E   L+                   L  QR     
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV-----------------DLDNQRQLVSN 1452

Query: 755  LQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRL 814
            L+++   F+    E + ++   +   ++ + EA+ K+     L R   +   A+ A   L
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE---ALEAKEEL 1509

Query: 815  KILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLA 874
            +   +   +    + S K+ +G  V   E +   +  + Q E+++               
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNV--HELEKSKRALETQMEEMK--------------- 1552

Query: 875  AIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSI--- 931
               + + EL+D + +A  ++++   + + A K  F + +       E       R +   
Sbjct: 1553 ---TQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 932  -TYVEKDSLVQRLA-------HGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRL 983
             T +E +   + LA        G  K   L     ++G     K    LQ Q+  F + L
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668

Query: 984  HAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELN 1043
              A   R  +     E ++    ++ +L       MQL E   +     ++ +   EEL 
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADL-------MQLQEDLAAAERARKQADLEKEELA 1721

Query: 1044 NALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRK-- 1101
              L      +  L ++ ++L+    +LE    EE    + + + V+  ++   +L  +  
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781

Query: 1102 -DQSLRQLNRHL-TQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRD 1159
             ++S  Q N     QLE+  + L   +H+ E A++  +K K  +A    A+E  + ++ +
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVK--SKFKSTIA----ALEAKIAQLEE 1835

Query: 1160 QI 1161
            Q+
Sbjct: 1836 QV 1837



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 103/505 (20%), Positives = 201/505 (39%), Gaps = 75/505 (14%)

Query: 11   DTQRLKIASLDVKQILKNET---ELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQI 67
            D QR  +++L+ KQ   ++    E +I+     +   A+ E  E  TK    LA    + 
Sbjct: 1444 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA-LSLARALEEA 1502

Query: 68   AKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKT 127
             + + E+E+   + ++   DL  ++ + G      E+         E++  Q  EL+ + 
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1562

Query: 128  NETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNR-------EYDLLMKEKSRLEKTL 180
              TE A    +   +    +FE DL+ RD   +   R       EY+  ++++ +     
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622

Query: 181  QEALEKHQREKNEMESHI------RETALEEFRLQEEQWEAERRELQFIVQEQD----TA 230
              A +K + +  ++E         RE A+++ R  + Q +  +REL+     +D    TA
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682

Query: 231  VQNMHKKVEKLETEHMDCSDLLR-----RQTSELEFSTQREE---------RLRKEFEAT 276
             +N  KK + LE + M   + L      R+ ++LE     EE          L+ E    
Sbjct: 1683 KEN-EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741

Query: 277  TLRVRKLEENIEAERAAHLESKFNSEIIQLRIR-------DLEGALQVEKASQAEAVADL 329
              R+ +LEE +E E+        N E +  R+R        L   L  E+++  +  +  
Sbjct: 1742 EARIAQLEEELEEEQG-------NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794

Query: 330  EIIKNEFKEVESAYEREKHNAQESF--------AKLNLLE--------------KEYFSK 367
            + ++ + KE+ S     +   +  F        AK+  LE              K    K
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854

Query: 368  NKKLNE---DIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKEL 424
            +KKL E    +E+++K+     ++ +       +L+ +L  A++    +        +EL
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914

Query: 425  ESILDSFTVSGQWTSGIHKDKDKPP 449
            +   +S    G+  + +      PP
Sbjct: 1915 DEATESNEAMGREVNALKSKLRGPP 1939



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 72/329 (21%), Positives = 141/329 (42%), Gaps = 48/329 (14%)

Query: 962  HVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKEL----DKAQGL 1017
            H  +T+    LQ+Q+   T+    AE  R  L  +  E +  ++EM+  L    D+ Q L
Sbjct: 889  HSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQL 948

Query: 1018 QMQLNEFKQSKLITHEKF-----------------ESACEELNNALLREEQAQMLLNEQA 1060
            Q +  +  Q  L   E+                  E+  ++L + +L  +     L+++ 
Sbjct: 949  QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008

Query: 1061 QQLQELNYKLELHSSEEADKNQTL----GEAVKSLSEAKMELRRKDQSLRQLNRHLTQLE 1116
            + L+E    L  + +EE +K + L     +    +SE ++ L+++++S ++L +   +LE
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068

Query: 1117 QDKRRLEENIHD-----AESALRMAAKDKECVA------NHMRAVENTLHKVRD------ 1159
             D     E I D     AE  +++A K++E  A      + +    N L K+R+      
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128

Query: 1160 --QISLSWSAASRNDFTLQLPKLHLETFAME-GLKGGPEVVACQAMIKSFMDVYQLASTR 1216
              Q  L    A+RN    Q   L  E  A++  L+   +  A Q  +++  +  Q  +  
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE--QEVTVL 1186

Query: 1217 IMTLEKEMTSHRSHIAALKSELHTACLRE 1245
               L++E  SH + +  ++ + H   + E
Sbjct: 1187 KKALDEETRSHEAQVQEMRQK-HAQAVEE 1214



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 139/656 (21%), Positives = 255/656 (38%), Gaps = 102/656 (15%)

Query: 585  KQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQED 644
            +Q E M  K    +     Q+  +  + +L + + ++   + + + +     EL    E+
Sbjct: 856  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915

Query: 645  TFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHE 704
               ++A + +  E   H  +  LE        E + R Q+ Q   +K  +++  +E   E
Sbjct: 916  MRVRLAAKKQELEEILHEMEARLE--------EEEDRGQQLQAERKKMAQQMLDLE---E 964

Query: 705  QLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFEL 764
            QL  E +  +KL    Q E+++  A    +   +  +  ++  LS +R  L+E+++    
Sbjct: 965  QLEEEEAARQKL----QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD--- 1017

Query: 765  FKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASL 824
                   L   L+  EEK +   K+K K          + +I+ L   RLK   +S   L
Sbjct: 1018 -------LTTNLAEEEEKAKNLTKLKNK---------HESMISELEV-RLKKEEKSRQEL 1060

Query: 825  FTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQ 884
                E  K  +      G+  D H       EQ+  LQA      ++L   +     ELQ
Sbjct: 1061 ----EKLKRKL-----EGDASDFH-------EQIADLQA----QIAELKMQLAKKEEELQ 1100

Query: 885  DVIGKADPNSRICGHLLIGAAKNSFAKLMD---KISLVMECIPLH-SSRSITYVEKDSLV 940
              + + D          I    N+  K+ +    IS + E +    ++R+    +K  L 
Sbjct: 1101 AALARLDDE--------IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152

Query: 941  QRLAHGLHKVNTLALKYGLRGHVPITKSTASLQ-KQILGFTQRLHAAEVERRSLRLEVTE 999
            + L          ALK  L   +  T +   L+ K+    T    A + E RS   +V E
Sbjct: 1153 EELE---------ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203

Query: 1000 FKR----SVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQML 1055
             ++    +V E+ ++L++ +  +  L++ KQ+    +         L  A    E  +  
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263

Query: 1056 LNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQL 1115
            L  Q Q+LQ      E   +E  DK   L   V+S++    E   K            +L
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK----------AIKL 1313

Query: 1116 EQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSA---ASRND 1172
             +D   L   + D +  L+   + K  V+  +R +E   + ++DQ+     A     R+ 
Sbjct: 1314 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373

Query: 1173 FTLQL----PKLHLETFA--MEGLKGGPEVVACQAMIKSFMDVYQLASTRIMTLEK 1222
             TL +     K  L+ FA  +E L+ G +    Q  I++    Y+  +     LEK
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKK--RFQKEIENLTQQYEEKAAAYDKLEK 1427



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 60/258 (23%), Positives = 112/258 (43%), Gaps = 26/258 (10%)

Query: 9    TGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTK----HNA---ELA 61
            T      K  SL+   +++ + +L   +  RK+    K+E  E         NA   E  
Sbjct: 1681 TAKENEKKAKSLEA-DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1739

Query: 62   SYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAG-LGRRAAEERLA--EAHRIQEKLCA 118
              E++IA+L  E+E+ +   +++   +  A ++A  L    A ER    +    +++L  
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEK 178
            QN EL++K +E E A ++   K+K      E  + + +  ++   RE     K   + +K
Sbjct: 1800 QNKELRSKLHEMEGAVKS---KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856

Query: 179  TLQEAL------------EKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQE 226
             L+E L             K Q EK        +  LEE   + ++  A RR+LQ  + E
Sbjct: 1857 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916

Query: 227  QDTAVQNMHKKVEKLETE 244
               + + M ++V  L+++
Sbjct: 1917 ATESNEAMGREVNALKSK 1934


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  125 bits (313), Expect = 4e-28
 Identities = 232/1191 (19%), Positives = 481/1191 (40%), Gaps = 177/1191 (14%)

Query: 13   QRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRS 72
            +R + A  ++K++ +  ++L    NL ++   A+ E      +    LA+ + ++ ++  
Sbjct: 866  ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925

Query: 73   EVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEK 132
            E+E      +     L   RK+        EE+L E    ++KL  +    +AK      
Sbjct: 926  EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK------ 979

Query: 133  AFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQ---R 189
                         ++ E ++   D+     ++E  LL +  S L   L E  EK +   +
Sbjct: 980  ------------IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027

Query: 190  EKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCS 249
             KN+ ES I E    E RL++E  E  R+EL+ + ++ +    + H+++  L+ +  +  
Sbjct: 1028 LKNKHESMISEL---EVRLKKE--EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082

Query: 250  DLLRRQTSELEFSTQR--EERLRKEFEATTLR-----VRKLEENIEAERAAHLESKFNS- 301
              L ++  EL+ +  R  +E  +K      +R     +  L+E++++ERAA  +++    
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142

Query: 302  ------EIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFA 355
                  E ++  + D   +   ++  +A+   ++ ++K    E     E   H AQ    
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-----ETRSHEAQ---- 1193

Query: 356  KLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVM---AKKHQAF 412
             +  + +++    ++L E +E+ K+   +L K  Q  EK  ++L  EL +   AK+    
Sbjct: 1194 -VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252

Query: 413  LVETCENNVKELES-ILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLED 471
              +  E  V+EL+S   D      +    +HK +++  S + +L             +  
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312

Query: 472  ASNEEKACNEL--DSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKV 529
             S++ +   EL  + T+QK++  TK +++L+++   +  +L        + E  ISTL +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1371

Query: 530  ELQNVLHCWEKEKAQAAQSESE-LQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPE 588
            +L +      K+K Q   S  E L++  + F K+ E     L   Y+   A    +++ +
Sbjct: 1372 QLSD-----SKKKLQDFASTVEALEEGKKRFQKEIEN----LTQQYEEKAAAYDKLEKTK 1422

Query: 589  GMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTK 648
                          LQ+ +D L+ DL+   + + +LE     K     +L   +++  +K
Sbjct: 1423 NR------------LQQELDDLVVDLDNQRQLVSNLE----KKQRKFDQLLAEEKNISSK 1466

Query: 649  VA-EQIKAQESCWHRQKKELELQYS-ELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQL 706
             A E+ +A+     ++ K L L  + E  LE ++  ++  ++ +  ME L   +    + 
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526

Query: 707  VLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFK 766
            V E    K+ L +TQ E+M                        TQ + L++++   E  K
Sbjct: 1527 VHELEKSKRAL-ETQMEEM-----------------------KTQLEELEDELQATEDAK 1562

Query: 767  LEIRTLAQAL---------STVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKIL 817
            L +    QAL         +  E+ +++  +++++  +    +  +     LAA   K L
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622

Query: 818  GQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAII 877
                  L    +S  +G                 +   +QLR LQA       D    + 
Sbjct: 1623 EGDLKDLELQADSAIKG----------------REEAIKQLRKLQA----QMKDFQRELE 1662

Query: 878  SSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKD 937
             + A   ++   A  N +         AK+  A LM    L  +      +R    +EK+
Sbjct: 1663 DARASRDEIFATAKENEK--------KAKSLEADLM---QLQEDLAAAERARKQADLEKE 1711

Query: 938  SLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEV 997
             L + LA  L   N L                  L+ +I    + L   +    ++   V
Sbjct: 1712 ELAEELASSLSGRNAL------------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759

Query: 998  TEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLN 1057
             +  +   ++  EL   +    +    +Q     +++  S   E+  A+  + ++ +   
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819

Query: 1058 EQAQQLQELNYKLELHSSEEADKNQTLGEAVKSL--------SEAKMELRRKDQS----- 1104
            E   ++ +L  ++E  + E+    ++L +  K L         E KM  + K+Q+     
Sbjct: 1820 E--AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877

Query: 1105 -LRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTL 1154
             ++QL R L + E++ +R+  N    +  L  A +  E +   + A+++ L
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928



 Score =  119 bits (299), Expect = 1e-26
 Identities = 213/1082 (19%), Positives = 445/1082 (41%), Gaps = 140/1082 (12%)

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEK 178
            Q  E+QAK +E         QK KE  ++ E++L+E +        E +LL ++     +
Sbjct: 850  QEEEMQAKEDEL--------QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901

Query: 179  TLQEALEKHQR---EKNEMES--HIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQN 233
               EA E   R   +K E+E   H  E  LEE   + +Q +AER+++   + + +  ++ 
Sbjct: 902  LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961

Query: 234  MHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENI--EAER 291
                 +KL+ E +     +++   E+     +  +L KE +    R+  L  N+  E E+
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021

Query: 292  AAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQ 351
            A +L    N    +  I +LE  L+ E+ S+ E    LE +K + +   S +  +  + Q
Sbjct: 1022 AKNLTKLKNKH--ESMISELEVRLKKEEKSRQE----LEKLKRKLEGDASDFHEQIADLQ 1075

Query: 352  ESFAKLNL----LEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEEL---- 403
               A+L +     E+E  +   +L+++I ++   +    K+++  E   S+LQE+L    
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSER 1131

Query: 404  ---VMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRR 460
                 A+K +  L E  E    ELE  LDS     +  +   ++          +  L++
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE----------VTVLKK 1181

Query: 461  TLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADR 520
             L +     E  S+E +         Q ++  T+ +++ +   A+++K    L  + AD 
Sbjct: 1182 ALDE-----ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236

Query: 521  EALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAG 580
               +  L    Q V H  +K +AQ  + +S+     +A   +  +K   +H L   + + 
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA-RAELNDK---VHKLQNEVESV 1292

Query: 581  CVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQ 640
              ++ + EG   K         L ++V +L + L    E ++       N S  +R+L++
Sbjct: 1293 TGMLNEAEGKAIK---------LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1343

Query: 641  TQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAE---KNMEKLN 697
             +     ++ E+++A+++   R    L +Q S+   ++Q  A   + + E   +  +++ 
Sbjct: 1344 ERNSLQDQLDEEMEAKQNL-ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402

Query: 698  HIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDF--- 754
            ++ + +E+        +K  ++ Q+E   L+                   L  QR     
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV-----------------DLDNQRQLVSN 1445

Query: 755  LQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRL 814
            L+++   F+    E + ++   +   ++ + EA+ K+     L R   +   A+ A   L
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE---ALEAKEEL 1502

Query: 815  KILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLA 874
            +   +   +    + S K+ +G  V   E +   +  + Q E+++               
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNV--HELEKSKRALETQMEEMK--------------- 1545

Query: 875  AIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSI--- 931
               + + EL+D + +A  ++++   + + A K  F + +       E       R +   
Sbjct: 1546 ---TQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 932  -TYVEKDSLVQRLA-------HGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRL 983
             T +E +   + LA        G  K   L     ++G     K    LQ Q+  F + L
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661

Query: 984  HAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELN 1043
              A   R  +     E ++    ++ +L       MQL E   +     ++ +   EEL 
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADL-------MQLQEDLAAAERARKQADLEKEELA 1714

Query: 1044 NALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRK-- 1101
              L      +  L ++ ++L+    +LE    EE    + + + V+  ++   +L  +  
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774

Query: 1102 -DQSLRQLNRHL-TQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRD 1159
             ++S  Q N     QLE+  + L   +H+ E A++  +K K  +A    A+E  + ++ +
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVK--SKFKSTIA----ALEAKIAQLEE 1828

Query: 1160 QI 1161
            Q+
Sbjct: 1829 QV 1830



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 103/505 (20%), Positives = 201/505 (39%), Gaps = 75/505 (14%)

Query: 11   DTQRLKIASLDVKQILKNET---ELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQI 67
            D QR  +++L+ KQ   ++    E +I+     +   A+ E  E  TK    LA    + 
Sbjct: 1437 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA-LSLARALEEA 1495

Query: 68   AKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKT 127
             + + E+E+   + ++   DL  ++ + G      E+         E++  Q  EL+ + 
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1555

Query: 128  NETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNR-------EYDLLMKEKSRLEKTL 180
              TE A    +   +    +FE DL+ RD   +   R       EY+  ++++ +     
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615

Query: 181  QEALEKHQREKNEMESHI------RETALEEFRLQEEQWEAERRELQFIVQEQD----TA 230
              A +K + +  ++E         RE A+++ R  + Q +  +REL+     +D    TA
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675

Query: 231  VQNMHKKVEKLETEHMDCSDLLR-----RQTSELEFSTQREE---------RLRKEFEAT 276
             +N  KK + LE + M   + L      R+ ++LE     EE          L+ E    
Sbjct: 1676 KEN-EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734

Query: 277  TLRVRKLEENIEAERAAHLESKFNSEIIQLRIR-------DLEGALQVEKASQAEAVADL 329
              R+ +LEE +E E+        N E +  R+R        L   L  E+++  +  +  
Sbjct: 1735 EARIAQLEEELEEEQG-------NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787

Query: 330  EIIKNEFKEVESAYEREKHNAQESF--------AKLNLLE--------------KEYFSK 367
            + ++ + KE+ S     +   +  F        AK+  LE              K    K
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847

Query: 368  NKKLNE---DIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKEL 424
            +KKL E    +E+++K+     ++ +       +L+ +L  A++    +        +EL
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907

Query: 425  ESILDSFTVSGQWTSGIHKDKDKPP 449
            +   +S    G+  + +      PP
Sbjct: 1908 DEATESNEAMGREVNALKSKLRGPP 1932



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 72/329 (21%), Positives = 141/329 (42%), Gaps = 48/329 (14%)

Query: 962  HVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKEL----DKAQGL 1017
            H  +T+    LQ+Q+   T+    AE  R  L  +  E +  ++EM+  L    D+ Q L
Sbjct: 882  HSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQL 941

Query: 1018 QMQLNEFKQSKLITHEKF-----------------ESACEELNNALLREEQAQMLLNEQA 1060
            Q +  +  Q  L   E+                  E+  ++L + +L  +     L+++ 
Sbjct: 942  QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001

Query: 1061 QQLQELNYKLELHSSEEADKNQTL----GEAVKSLSEAKMELRRKDQSLRQLNRHLTQLE 1116
            + L+E    L  + +EE +K + L     +    +SE ++ L+++++S ++L +   +LE
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061

Query: 1117 QDKRRLEENIHD-----AESALRMAAKDKECVA------NHMRAVENTLHKVRD------ 1159
             D     E I D     AE  +++A K++E  A      + +    N L K+R+      
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121

Query: 1160 --QISLSWSAASRNDFTLQLPKLHLETFAME-GLKGGPEVVACQAMIKSFMDVYQLASTR 1216
              Q  L    A+RN    Q   L  E  A++  L+   +  A Q  +++  +  Q  +  
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE--QEVTVL 1179

Query: 1217 IMTLEKEMTSHRSHIAALKSELHTACLRE 1245
               L++E  SH + +  ++ + H   + E
Sbjct: 1180 KKALDEETRSHEAQVQEMRQK-HAQAVEE 1207



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 139/656 (21%), Positives = 255/656 (38%), Gaps = 102/656 (15%)

Query: 585  KQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQED 644
            +Q E M  K    +     Q+  +  + +L + + ++   + + + +     EL    E+
Sbjct: 849  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908

Query: 645  TFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHE 704
               ++A + +  E   H  +  LE        E + R Q+ Q   +K  +++  +E   E
Sbjct: 909  MRVRLAAKKQELEEILHEMEARLE--------EEEDRGQQLQAERKKMAQQMLDLE---E 957

Query: 705  QLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFEL 764
            QL  E +  +KL    Q E+++  A    +   +  +  ++  LS +R  L+E+++    
Sbjct: 958  QLEEEEAARQKL----QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD--- 1010

Query: 765  FKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASL 824
                   L   L+  EEK +   K+K K          + +I+ L   RLK   +S   L
Sbjct: 1011 -------LTTNLAEEEEKAKNLTKLKNK---------HESMISELEV-RLKKEEKSRQEL 1053

Query: 825  FTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQ 884
                E  K  +      G+  D H       EQ+  LQA      ++L   +     ELQ
Sbjct: 1054 ----EKLKRKL-----EGDASDFH-------EQIADLQA----QIAELKMQLAKKEEELQ 1093

Query: 885  DVIGKADPNSRICGHLLIGAAKNSFAKLMD---KISLVMECIPLH-SSRSITYVEKDSLV 940
              + + D          I    N+  K+ +    IS + E +    ++R+    +K  L 
Sbjct: 1094 AALARLDDE--------IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145

Query: 941  QRLAHGLHKVNTLALKYGLRGHVPITKSTASLQ-KQILGFTQRLHAAEVERRSLRLEVTE 999
            + L          ALK  L   +  T +   L+ K+    T    A + E RS   +V E
Sbjct: 1146 EELE---------ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196

Query: 1000 FKR----SVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQML 1055
             ++    +V E+ ++L++ +  +  L++ KQ+    +         L  A    E  +  
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256

Query: 1056 LNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQL 1115
            L  Q Q+LQ      E   +E  DK   L   V+S++    E   K            +L
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK----------AIKL 1306

Query: 1116 EQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSA---ASRND 1172
             +D   L   + D +  L+   + K  V+  +R +E   + ++DQ+     A     R+ 
Sbjct: 1307 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366

Query: 1173 FTLQL----PKLHLETFA--MEGLKGGPEVVACQAMIKSFMDVYQLASTRIMTLEK 1222
             TL +     K  L+ FA  +E L+ G +    Q  I++    Y+  +     LEK
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKK--RFQKEIENLTQQYEEKAAAYDKLEK 1420



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 60/258 (23%), Positives = 112/258 (43%), Gaps = 26/258 (10%)

Query: 9    TGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTK----HNA---ELA 61
            T      K  SL+   +++ + +L   +  RK+    K+E  E         NA   E  
Sbjct: 1674 TAKENEKKAKSLEA-DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1732

Query: 62   SYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAG-LGRRAAEERLA--EAHRIQEKLCA 118
              E++IA+L  E+E+ +   +++   +  A ++A  L    A ER    +    +++L  
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEK 178
            QN EL++K +E E A ++   K+K      E  + + +  ++   RE     K   + +K
Sbjct: 1793 QNKELRSKLHEMEGAVKS---KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849

Query: 179  TLQEAL------------EKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQE 226
             L+E L             K Q EK        +  LEE   + ++  A RR+LQ  + E
Sbjct: 1850 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909

Query: 227  QDTAVQNMHKKVEKLETE 244
               + + M ++V  L+++
Sbjct: 1910 ATESNEAMGREVNALKSK 1927


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  118 bits (295), Expect = 4e-26
 Identities = 271/1333 (20%), Positives = 537/1333 (40%), Gaps = 172/1333 (12%)

Query: 40   KKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGR 99
            K LH   ++K ++  + N  +     +I  L  E +K ++   +L+ +L+   +E     
Sbjct: 823  KTLHMDFEQKYKMVLEENERM---NQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKT 879

Query: 100  RAAEERLAEAHRIQEKLCAQNSELQA----KTNETEKAFQTSQQ-----KWKEECRRFEH 150
            R  +ERL E  +++E+L  ++S LQ     KT  TEK  QT ++     + K++ ++ + 
Sbjct: 880  REVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQE 939

Query: 151  DLE-ERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQ 209
             L+ ERD +  + +   ++ +  + +L   L E+L++HQ   N ++S I E       ++
Sbjct: 940  SLQIERDQLKSDIHDTVNMNIDTQEQLRNAL-ESLKQHQETINTLKSKISEEVSRNLHME 998

Query: 210  EEQWEAE---RRELQFIVQEQDTAVQN---------------MHKKVEKLETEHMDCSDL 251
            E   E +   ++++  I ++QD   +N                 +K+  L  E  +   +
Sbjct: 999  ENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM 1058

Query: 252  LRRQTSELE-FSTQREERLRKEFE-ATTLRVR----KLEENIEAERAAHLESKFNSEIIQ 305
            L    +E E   T  +E +    E    LR+     K ++ I A+   H   K   E+ +
Sbjct: 1059 LESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKK-EGELSR 1117

Query: 306  L--RIRDLEGALQVEKASQAEAVADLEIIKNEFKEVE---SAYEREKHNAQESFAKLNLL 360
               R+ ++E  L+ +     E    L  ++ E  E++   +  E  K+  +     L  +
Sbjct: 1118 TCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHM 1177

Query: 361  EKEYFSKNKKLNEDIEE------QKKVIIDLSKRLQYN-----------EKSCSELQEEL 403
            E E     +KLNE+ EE      ++KV+ +L K  +             E +  + +EEL
Sbjct: 1178 ETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEEL 1237

Query: 404  VMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLT 463
             +A  H    ++  +  + EL   +   T     T  + K   K      VL   +  L 
Sbjct: 1238 KIAHIH----LKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLP 1293

Query: 464  DYQ--NKLEDASNEEKACNELDSTKQ-----KIDSH----TKNIKELQDKLADVNKELSH 512
            + +  ++ ++  NE +   E  +TK      +I+       +  +E Q+++  + KE  +
Sbjct: 1294 NVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDN 1353

Query: 513  LHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHT 572
            L T     E     LK  ++  L      K Q +QS+ E Q L+    KD  E    +  
Sbjct: 1354 LKTIKEALEVKHDQLKEHIRETL-----AKIQESQSKQE-QSLNMK-EKD-NETTKIVSE 1405

Query: 573  LYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKS 632
            + Q       L++    ML       L   LQE+ D +   + +  + ++ L+ + +++S
Sbjct: 1406 MEQFKPKDSALLRIEIEMLG------LSKRLQESHDEM-KSVAKEKDDLQRLQEVLQSES 1458

Query: 633  DTMRELQQTQEDTFTKVAEQIKAQESCWHRQKK---ELELQYSELFLEVQKRAQKFQEIA 689
            D ++E  +       +  E++K    C   Q++   EL +  SE   E+    ++ + I 
Sbjct: 1459 DQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIN 1518

Query: 690  EKNMEKLNHIEKSHEQLVLEN-SHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCAL 748
            +K   K+  I +  EQ  ++  S  ++ +++ ++ +    A  +    AL  + S+   L
Sbjct: 1519 DKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDS----ALQSIESKMLEL 1574

Query: 749  STQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAV 808
            + +    QE++      K E++ + +AL        E  ++K+ T         K ++A 
Sbjct: 1575 TNRLQESQEEIQIMIKEKEEMKRVQEALQI------ERDQLKENT---------KEIVAK 1619

Query: 809  LAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRC--LQALSW 866
            +  ++ K         + +++        +    E Q+K    +H KEQ     L   + 
Sbjct: 1620 MKESQEKE--------YQFLK--------MTAVNETQEKMCEIEHLKEQFETQKLNLENI 1663

Query: 867  LTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLH 926
             T +  L  I+    E    + K   + R     L          L + I+  +E     
Sbjct: 1664 ETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEEL 1723

Query: 927  SSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAA 986
                +   E    + +L  G+    T  +    +    +  S  +L+ Q L   + L  A
Sbjct: 1724 KIVHMHLKEHQETIDKL-RGIVSEKTNEISNMQKD---LEHSNDALKAQDLKIQEELRIA 1779

Query: 987  EVERRS-------LRLEVTEFKRSVNEMKKELDKAQG-LQMQLNEFK--QSKLITHEKFE 1036
             +  +        LR  V+E    ++ M+K+L+ +   LQ ++ E K  + +LIT +K  
Sbjct: 1780 HMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKK-- 1837

Query: 1037 SACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKM 1096
                E    +   EQ +  + +Q+  L     KLE+ +   A K     E +KS+ + + 
Sbjct: 1838 -DVNETQKKVSEMEQLKKQIKDQSLTLS----KLEIENLNLAQKLHENLEEMKSVMKERD 1892

Query: 1097 ELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRA------- 1149
             LRR +++L+     L +  Q+ +  +  I       RM +K+ +   + +R        
Sbjct: 1893 NLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTI 1952

Query: 1150 ----VENTLHKVRDQISLSWSAASRNDFTLQLPK-----LHLETFAMEGLKGGPEVVACQ 1200
                ++  L K +D++        + +  L   K      H +   ME LK   E     
Sbjct: 1953 QISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNL- 2011

Query: 1201 AMIKSFMDVYQLASTRIMTLE--KEMTSHRSHIAALKSELHTACLRENASLQSIGSRDHS 1258
            +M    MD +QL      +LE  + +   R  +  +K  L     +  A+L+ + +RD  
Sbjct: 2012 SMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQ 2071

Query: 1259 NLSIPSRAPLPAD 1271
            N  +     L +D
Sbjct: 2072 NHQVKPEKRLLSD 2084



 Score =  111 bits (278), Expect = 4e-24
 Identities = 276/1355 (20%), Positives = 545/1355 (40%), Gaps = 193/1355 (14%)

Query: 47   KEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERL 106
            KE+L+I   H   L  ++  I +LR  V +  A          +  ++        +E +
Sbjct: 1234 KEELKIAHIH---LKEHQETIDELRRSVSEKTAQ--------IINTQDLEKSHTKLQEEI 1282

Query: 107  AEAHRIQEKL--CAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNR 164
               H  QE L    + SE Q   NE E   + S  K      R E +    +   Q    
Sbjct: 1283 PVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQE 1342

Query: 165  EYDLLMKEKSRLEKTLQEALE-KHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFI 223
            E   L KE+  L KT++EALE KH    ++++ HIRET     ++QE Q    ++E    
Sbjct: 1343 EIKSLTKERDNL-KTIKEALEVKH----DQLKEHIRETLA---KIQESQ---SKQEQSLN 1391

Query: 224  VQEQDTAVQNMHKKVE----------KLETEHMDCSDLLRRQTSELEFSTQREERLRKEF 273
            ++E+D     +  ++E          ++E E +  S  L+    E++   + ++ L++  
Sbjct: 1392 MKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQ 1451

Query: 274  EATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIK 333
            E       +L+ENI+   A HLE++   ++    +++ E  +   + + +E   ++  I+
Sbjct: 1452 EVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQ 1511

Query: 334  NEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNE 393
               K++E+  ++ ++  QE + K      +  S+ ++   ++++ K+        LQ  E
Sbjct: 1512 ---KQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIE 1568

Query: 394  KSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSV 453
                EL   L  +++    +++  E  +K ++  L            I +D+ K  +  +
Sbjct: 1569 SKMLELTNRLQESQEEIQIMIKEKE-EMKRVQEALQ-----------IERDQLKENTKEI 1616

Query: 454  VLERLRRTLTDYQNKLEDASNE--EKACNELDSTKQKIDSHTKNIKELQD---KLADV-N 507
            V +       +YQ     A NE  EK C E++  K++ ++   N++ ++    +L  + +
Sbjct: 1617 VAKMKESQEKEYQFLKMTAVNETQEKMC-EIEHLKEQFETQKLNLENIETENIRLTQILH 1675

Query: 508  KELSHLHTKCADREALIS---TLKVELQNVLHCWEKEKAQAAQSESELQKLSQAF--HKD 562
            + L  + +   +R+ L S   TLKVE   +     +   +  + + EL+ +      H++
Sbjct: 1676 ENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQE 1735

Query: 563  AEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIR 622
              +KL  + +   + ++   + K  E   D     +L   +QE +      L    E I 
Sbjct: 1736 TIDKLRGIVSEKTNEISN--MQKDLEHSNDALKAQDL--KIQEELRIAHMHLKEQQETID 1791

Query: 623  HLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWH--------------------- 661
             L  I   K+D +  +Q+  E++  K+ E+I+  ++  H                     
Sbjct: 1792 KLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQ 1851

Query: 662  --RQKKELELQYSELFLEVQKRAQKFQEIAEKN---MEKLNHIEKSHEQLVLENSHFKKL 716
              +Q K+  L  S+L +E    AQK  E  E+    M++ +++ +  E L LE    K+ 
Sbjct: 1852 LKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKES 1911

Query: 717  LSQTQRE----QMSLLAACAL--------------MAGALYPLYSRSCALSTQRDFLQEQ 758
            L +T+      Q  L  A  L              ++     +      L   +D LQ++
Sbjct: 1912 LQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKK 1971

Query: 759  VNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKG------LIRIFRKGVIAVL--A 810
            +   +  +L++  + + ++ +  KK  E +  KK F+        +R+    +   L  +
Sbjct: 1972 IQELQKKELQLLRVKEDVN-MSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHES 2030

Query: 811  ANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSS 870
               ++I+ +    L    ES K      + T           HQ +  + L +      +
Sbjct: 2031 LEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLT 2090

Query: 871  DLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKN-SFAKLMD---KISLVMECIPL- 925
            + L    S + EL     + D +      L +   K   F K +    K +L +  +   
Sbjct: 2091 ESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTK 2150

Query: 926  HSSRSITYVEKDSL-VQRLAHGLHKVNTLALKYGLRGHVPITK------STASLQKQILG 978
            H  +  T  ++ S+   R+   L  V +   K     H  I K           QK++L 
Sbjct: 2151 HIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLI 2210

Query: 979  FTQRLHA-AEVERRSLR---------LEVTEFKRSVNE-----MKKELDKAQGLQMQLNE 1023
              Q L    +V  R LR         L + E  +  +E     +K E  +    + ++ +
Sbjct: 2211 KIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQ 2270

Query: 1024 FKQSKLITH---EKFESACEELNNALLR-------------------EEQAQMLLNEQAQ 1061
            F +  L T    EK ++  ++ N+ + +                   EE++  +  E  Q
Sbjct: 2271 FLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQ 2330

Query: 1062 QLQELNYKLELHSSEEADKN-QTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDK- 1119
             L+ L  K     +E+  KN QTL  ++   S A++    +D     +    TQL  +K 
Sbjct: 2331 DLKSLKEK-----NEKLFKNYQTLKTSL--ASGAQVNPTTQDNKNPHVTSRATQLTTEKI 2383

Query: 1120 RRLEENIHDA-ESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLP 1178
            R LE ++H+A ESA+   +K  + +   +    + + K++ ++  S     +   T+Q+ 
Sbjct: 2384 RELENSLHEAKESAMHKESKIIK-MQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQV- 2441

Query: 1179 KLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKSEL 1238
               L+     G K   E +    M    +D+ ++ + +    EKE+++ ++ +   K  +
Sbjct: 2442 ---LQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAK--EFEKEISATKATVEYQKEVI 2496

Query: 1239 HTACLRENASLQSIGSRDHSNLS-----IPSRAPL 1268
                LREN   +S  ++D S +S      PS  PL
Sbjct: 2497 R--LLRENLR-RSQQAQDTSVISEHTDPQPSNKPL 2528



 Score =  107 bits (267), Expect = 8e-23
 Identities = 266/1294 (20%), Positives = 521/1294 (40%), Gaps = 235/1294 (18%)

Query: 57   NAELASYESQIAK-LRSEVEKGEALRQS--LEYDLAVARKEAGLGRRAAEERLAEAHRI- 112
            N EL    + + K L  EVE+ EALR+   L  +L     E    R+  +++  E H I 
Sbjct: 715  NLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIIT 774

Query: 113  --QEKLCAQ----NSELQAKTNE---TEKAFQTSQQKWKEECRRFEH------DLEERDN 157
              ++KL ++     S +Q    E   T+    T+Q  +K   + F++      D E++  
Sbjct: 775  SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYK 834

Query: 158  MI----QNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETA--LEEFRLQEE 211
            M+    +  N+E   L KE  + + +L     +   +  E++   RE    L E    +E
Sbjct: 835  MVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKE 894

Query: 212  QWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQRE-ERLR 270
            Q E     LQ + +E+    + + + +E+++T   +  DL      +L+ S Q E ++L+
Sbjct: 895  QLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDL-----KQLQESLQIERDQLK 949

Query: 271  KEFEATTLRVRKLEENIEAERAAHLESKFNS-EIIQLRIRDLEGALQVEKASQAEAVADL 329
             +   T         N+  +    L +   S +  Q  I  L+  +  E +       + 
Sbjct: 950  SDIHDTV--------NMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENT 1001

Query: 330  EIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRL 389
               K+EF++     ++++         L     +  + + K NE IE+Q+K+   + ++ 
Sbjct: 1002 GETKDEFQQKMVGIDKKQD--------LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEK- 1052

Query: 390  QYNEKSCSELQE--ELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDK 447
                   +ELQ+  E V+A+K Q  L    + N++         T+  Q    +  D+ K
Sbjct: 1053 -------NELQQMLESVIAEKEQ--LKTDLKENIE--------MTIENQEELRLLGDELK 1095

Query: 448  PPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVN 507
                 V  E+         + ++      + C+ L   ++K+   ++ ++E Q +L +V 
Sbjct: 1096 KQQEIVAQEK--------NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQ 1147

Query: 508  KELSHLHTKCADREALISTLKVELQN---VLHCWEKEKAQAAQSESE------------- 551
            +E+S +  K  +    I  LK EL+N    L   E E+ + AQ  +E             
Sbjct: 1148 EEMSEMQKKINE----IENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERK 1203

Query: 552  -LQKLSQAFHKDAEEKLTFLHTL-------YQHLVAGCVLIKQPEGMLDKF--SWSELCA 601
             L++L ++F  + +    ++  +        + L    + +K+ +  +D+   S SE  A
Sbjct: 1204 VLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTA 1263

Query: 602  -------------VLQENVDAL---------IADLNRANEKIRHLEYICKNK----SDTM 635
                          LQE +  L         + +++   E +  LE + +      S T+
Sbjct: 1264 QIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTL 1323

Query: 636  RELQQTQ---EDTFTKVAEQIKA---QESCWHRQKKELELQYSELFLEVQKRAQKFQEIA 689
              ++  +    + F +  E+IK+   +       K+ LE+++ +L   +++   K QE  
Sbjct: 1324 ARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQ 1383

Query: 690  EKNMEKLNHIEKSHE--QLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCA 747
             K  + LN  EK +E  ++V E   FK   S   R ++ +L     ++  L   +    +
Sbjct: 1384 SKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLG----LSKRLQESHDEMKS 1439

Query: 748  LSTQRDFLQE-----QVNTFELFKLEIRTLAQALSTVEEKKQEEA--KMKKKTFKGL-IR 799
            ++ ++D LQ      Q  + +L +     +A+ L T EE K      K +++T   L + 
Sbjct: 1440 VAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVN 1499

Query: 800  IFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDK----HKFPKHQK 855
            +  K         +L+ +     +    +   +E   +   + E Q+K     +F +H+K
Sbjct: 1500 LSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQIS-EVQEKVNELKQFKEHRK 1558

Query: 856  EQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGA------AKNSF 909
             +   LQ++      +L   +  S  E+Q +I + +   R+   L I         K   
Sbjct: 1559 AKDSALQSIE-SKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIV 1617

Query: 910  AKLMD---------KISLVME-----CIPLH-------SSRSITYVEKDSLVQRLAHGLH 948
            AK+ +         K++ V E     C   H          ++  +E +++  RL   LH
Sbjct: 1618 AKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENI--RLTQILH 1675

Query: 949  -----------------------KVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHA 985
                                   KV    LK  LR  +     T  L+KQ       +H 
Sbjct: 1676 ENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETI-----TRDLEKQEELKIVHMHL 1730

Query: 986  AEVERR--SLRLEVTEFKRSVNEMKKELDKA-QGLQMQLNEFKQSKLITHEKFESACEEL 1042
             E +     LR  V+E    ++ M+K+L+ +   L+ Q  + ++   I H   +   E +
Sbjct: 1731 KEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETI 1790

Query: 1043 NNAL-LREEQAQMLLNEQAQQLQELNYKLELHSSE-EADKNQ--TLGEAVKSLSEAKMEL 1098
            +    +  E+   L N Q + L+  N KL+    E +A+++Q  TL + V    +   E+
Sbjct: 1791 DKLRGIVSEKTDKLSNMQ-KDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM 1849

Query: 1099 RRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVR 1158
             +  + ++  +  L++LE +   L + +H+    ++   K+++    ++R VE TL   R
Sbjct: 1850 EQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD----NLRRVEETLKLER 1905

Query: 1159 DQISLSWSAASRNDFTLQ--------LPKLHLET 1184
            DQ+  S       D  +Q        L K H ET
Sbjct: 1906 DQLKESLQETKARDLEIQQELKTARMLSKEHKET 1939



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 206/1067 (19%), Positives = 430/1067 (40%), Gaps = 166/1067 (15%)

Query: 112  IQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMK 171
            I E +C++ S++ + T +T      S+ +W    +      E  ++ + +   +YD L+ 
Sbjct: 461  IDESVCSE-SDVFSNTLDT-----LSEIEWNPATKLLNQ--ENIESELNSLRADYDNLVL 512

Query: 172  EKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAV 231
            +  +L +T +E +E   +EKN+         L+EF   E + + ++ E+Q I +     +
Sbjct: 513  DYEQL-RTEKEEMELKLKEKND---------LDEFEALERKTKKDQ-EMQLIHE-----I 556

Query: 232  QNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAER 291
             N+   V+  E  + D  + L   +S++E   ++E++++K  E   +  +KLE NI+ + 
Sbjct: 557  SNLKNLVKHAEVYNQDLENEL---SSKVELLREKEDQIKKLQEY--IDSQKLE-NIKMDL 610

Query: 292  AAHLESKFNSEIIQLRIRDLEG-ALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNA 350
            +  LES  + + ++  + D E  AL  ++ S      +LE+ K + KE+ + Y++ +++ 
Sbjct: 611  SYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLEL-KEKMKELATTYKQMENDI 669

Query: 351  QESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQ 410
            Q                       +E +KK+ +DL K LQ                    
Sbjct: 670  Q------------------LYQSQLEAKKKMQVDLEKELQ-------------------S 692

Query: 411  AFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLE 470
            AF      N + +L S++D                 K P   +    L   +TD Q +L 
Sbjct: 693  AF------NEITKLTSLIDG----------------KVPKDLLCNLELEGKITDLQKELN 730

Query: 471  DASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTL--- 527
                E +A  E      ++ S    ++ L+ ++ D ++E   LH   ++++ L S +   
Sbjct: 731  KEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEE---LHIITSEKDKLFSEVVHK 787

Query: 528  KVELQNVLHCWEKEKAQAAQSESELQKLSQAF------HKDAEEKLTFLHTLYQHLVAGC 581
            +  +Q +L    K K   A ++S  +   Q F      H D E+K   +    + +    
Sbjct: 788  ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847

Query: 582  VLIKQPEGMLD------KFSWSELCAVLQE---NVDALIADLNRANEKIRH----LEYIC 628
            V + +     D      K   S     LQE    V   + ++ +  E++ +    L+ + 
Sbjct: 848  VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907

Query: 629  KNKSDTMRELQQTQED--TFTKVAEQIKAQESCWHRQKKELELQYSE---LFLEVQKRAQ 683
            + K+    +LQQT E+  T T+  + +K  +     ++ +L+    +   + ++ Q++ +
Sbjct: 908  REKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLR 967

Query: 684  KFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYS 743
               E  +++ E +N ++    + V  N H ++   +T+ E    +               
Sbjct: 968  NALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ 1027

Query: 744  RSCALSTQRDFLQEQVNTFELFKLEIRTLAQAL-STVEEKKQEEAKMKKKTFKGLIRIFR 802
               A     + +++Q   F L + E   L Q L S + EK+Q +  +K+     +     
Sbjct: 1028 TLTADVKDNEIIEQQRKIFSLIQ-EKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEE 1086

Query: 803  KGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQ 862
              ++      + +I+ Q            KEG     C    + + K  K + +QL+   
Sbjct: 1087 LRLLGDELKKQQEIVAQEKNHAIK-----KEGELSRTCDRLAEVEEKL-KEKSQQLQ--- 1137

Query: 863  ALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMEC 922
                      L  +   M+E+Q  I + +         L    KN   K +    +  E 
Sbjct: 1138 -----EKQQQLLNVQEEMSEMQKKINEIEN--------LKNELKN---KELTLEHMETER 1181

Query: 923  IPLHSSRSITYVEKDSLV--QRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFT 980
            + L    +  Y E  S+   +++   L K       + LRG++   ++T    K      
Sbjct: 1182 LELAQKLNENYEEVKSITKERKVLKELQKSFETERDH-LRGYIREIEATGLQTK------ 1234

Query: 981  QRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFE--SA 1038
            + L  A +  +  +  + E +RSV+E   ++   Q L+    + ++   + HE+ E    
Sbjct: 1235 EELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPN 1294

Query: 1039 CEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMEL 1098
             +E++       + ++L  +   +      ++E+      +K Q   E +KSL++ +  L
Sbjct: 1295 VKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL 1354

Query: 1099 RRKDQSLR----QLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKE 1141
            +   ++L     QL  H   + +   +++E+    E +L M  KD E
Sbjct: 1355 KTIKEALEVKHDQLKEH---IRETLAKIQESQSKQEQSLNMKEKDNE 1398



 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 139/730 (19%), Positives = 303/730 (41%), Gaps = 87/730 (11%)

Query: 11   DTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKL 70
            +TQ+L + +++ + I        +T  L + L     E++   TK   +L S E  +   
Sbjct: 1654 ETQKLNLENIETENIR-------LTQILHENL-----EEMRSVTKERDDLRSVEETLKVE 1701

Query: 71   RSEVEKGEALRQSLEYDLAVAR--KEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTN 128
            R +++  E LR+++  DL      K   +  +  +E + +   I  +   + S +Q    
Sbjct: 1702 RDQLK--ENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLE 1759

Query: 129  ETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQ 188
             +  A +    K +EE R     L+E+   I            + S ++K L+ +  K Q
Sbjct: 1760 HSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQ 1819

Query: 189  REKNEMESHIRETALEEFRLQEEQWE-AERRELQFIVQEQDTAVQNMHKKVEKLETEHMD 247
             +  E++++  +    +  + E Q + +E  +L+  +++Q   +        KLE E+++
Sbjct: 1820 EKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLS-------KLEIENLN 1872

Query: 248  CSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLR 307
             +  L     E++   +  + LR+  E   L   +L+E+++  +A  LE     E+   R
Sbjct: 1873 LAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLE--IQQELKTAR 1930

Query: 308  IRDLEGALQVEKASQ--AEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYF 365
            +   E    V+K  +  +E    +  I+ +  + +   +++    Q+   +L  ++++  
Sbjct: 1931 MLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVN 1990

Query: 366  SKNKKLNEDIEEQKKVI--IDLSKR------LQYNEKSCSELQEELVMAKKHQAFLVETC 417
              +KK+NE +E+ KK     +LS +       Q  +K    L+E  ++AK+         
Sbjct: 1991 MSHKKINE-MEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERD------- 2042

Query: 418  ENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEK 477
                 EL  I +S  +            ++    + + E + R   ++Q K E     + 
Sbjct: 2043 -----ELRRIKESLKM------------ERDQFIATLREMIARDRQNHQVKPEKRLLSDG 2085

Query: 478  ACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHC 537
              +  +S ++K       IKEL  + ++++      H +C +R +L    ++E Q  L  
Sbjct: 2086 QQHLTESLREK----CSRIKELLKRYSEMDD-----HYECLNRLSLDLEKEIEFQKELSM 2136

Query: 538  WEKEKAQAAQSESE-LQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSW 596
              K        +++ ++KL  A  + + E    +  L   L     + ++    ++KF  
Sbjct: 2137 RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEM 2196

Query: 597  SELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQ 656
              +  V ++  + LI        KI+HL+  C   S  +R+L+  Q        E+I   
Sbjct: 2197 DFIDEV-EKQKELLI--------KIQHLQQDCDVPSRELRDLKLNQ--NMDLHIEEILKD 2245

Query: 657  ESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEK--NMEKL-NHIEKSHEQLVLENSHF 713
             S    +   ++ ++ ++    ++  Q  +E      ++EKL N I+K ++++   N+ F
Sbjct: 2246 FS--ESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFF 2303

Query: 714  KKLLSQTQRE 723
               +     E
Sbjct: 2304 NNRIIAIMNE 2313



 Score = 34.7 bits (78), Expect = 0.62
 Identities = 63/395 (15%), Positives = 159/395 (40%), Gaps = 71/395 (17%)

Query: 64   ESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEA-HRIQEKLCAQNS- 121
            ES+   +++E ++  + R+ +   L     E  L  R   E+L     +  +++C  N+ 
Sbjct: 2248 ESEFPSIKTEFQQVLSNRKEMTQFL-----EEWLNTRFDIEKLKNGIQKENDRICQVNNF 2302

Query: 122  ------ELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSR 175
                   +  ++ E E+   T  ++W+++ +  +   E+              L K    
Sbjct: 2303 FNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEK--------------LFKNYQT 2348

Query: 176  LEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMH 235
            L+ +L    + +   ++    H+   A +   L  E+     REL+  + E   +  +  
Sbjct: 2349 LKTSLASGAQVNPTTQDNKNPHVTSRATQ---LTTEKI----RELENSLHEAKESAMHKE 2401

Query: 236  KKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEA----TTLRVRKLEENIEAER 291
             K+ K++ E    +D++ +  +++  S +  E+ ++  +       L  +  +E IE   
Sbjct: 2402 SKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIE--- 2458

Query: 292  AAHLESKFNSEIIQLRIRDLEGALQVEKA-SQAEAVAD-----LEIIKNEFKEVESAYER 345
                      +++++ +  ++ A + EK  S  +A  +     + +++   +  + A + 
Sbjct: 2459 ------DLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDT 2512

Query: 346  ----EKHNAQESFAKLN--------------LLEKEYFSKNKKLNEDIEEQKKVIIDLSK 387
                E  + Q S   L               +L+ E+    K++++  ++ +++I   ++
Sbjct: 2513 SVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNE 2572

Query: 388  RLQYNEKSCSELQEELVMAKKHQAFLVETCENNVK 422
             L  N+   +E++       K +A    TCEN+ K
Sbjct: 2573 LLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPK 2607



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 47/220 (21%), Positives = 94/220 (42%), Gaps = 19/220 (8%)

Query: 1027 SKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGE 1086
            +KL+  E  ES   ELN+  LR +   ++L+ +  QL+    ++EL   E+ D ++    
Sbjct: 488  TKLLNQENIES---ELNS--LRADYDNLVLDYE--QLRTEKEEMELKLKEKNDLDEFEAL 540

Query: 1087 AVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANH 1146
              K+  + +M+L  +  +L+ L +H     QD   LE  +      LR    +KE     
Sbjct: 541  ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQD---LENELSSKVELLR----EKEDQIKK 593

Query: 1147 MRAVENTLHKVRDQISLSWSAASRND-FTLQLPKLHLETFAMEGLKGG----PEVVACQA 1201
            ++   ++      ++ LS+S  S  D   ++      ET A++  +       E +  + 
Sbjct: 594  LQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKE 653

Query: 1202 MIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTA 1241
             +K     Y+     I   + ++ + +     L+ EL +A
Sbjct: 654  KMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSA 693



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 44/195 (22%), Positives = 86/195 (44%), Gaps = 23/195 (11%)

Query: 988  VERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHE-----KFESACEEL 1042
            ++   LR E  E +  + E K +LD+ + L+ +  + ++ +LI HE           E  
Sbjct: 512  LDYEQLRTEKEEMELKLKE-KNDLDEFEALERKTKKDQEMQLI-HEISNLKNLVKHAEVY 569

Query: 1043 NNALLREEQAQM-LLNEQAQQLQEL----------NYKLELHSSEEADKN-----QTLGE 1086
            N  L  E  +++ LL E+  Q+++L          N K++L  S E+ ++     QTL +
Sbjct: 570  NQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFD 629

Query: 1087 AVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANH 1146
            A     +AK E         +L   + +L    +++E +I   +S L    K +  +   
Sbjct: 630  AETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKE 689

Query: 1147 MRAVENTLHKVRDQI 1161
            +++  N + K+   I
Sbjct: 690  LQSAFNEITKLTSLI 704


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  117 bits (294), Expect = 6e-26
 Identities = 247/1251 (19%), Positives = 507/1251 (40%), Gaps = 224/1251 (17%)

Query: 17   IASLDVKQILKNETELDITD-NLRK----------KLHWAKKEKLEITTKHNAELASYES 65
            +A ++ K++L+    L +   N+R           KL++  K  L+ + +   E+AS + 
Sbjct: 796  LARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLK-SAEREKEMASMKE 854

Query: 66   QIAKLRSEVEKGEALRQSLE---YDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSE 122
            +  +L+  +EK EA R+ LE     L   + +  L  +A ++ LA+A    ++L     +
Sbjct: 855  EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ 914

Query: 123  LQAKTNETEKAFQTSQQ----------KWKEECRRFEHDLEE--------------RDNM 158
            L+AK  E  +  +  ++          K ++EC   + D+++               +N 
Sbjct: 915  LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENK 974

Query: 159  IQNCNREYD-------LLMKEKSRLEKTLQEALEKHQREKNEMESHIR-----ETALEEF 206
            ++N   E          L KEK  L++  Q+AL+  Q E++++ +  +     E  +++ 
Sbjct: 975  VKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDL 1034

Query: 207  RLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQRE 266
                EQ +  R +L+   ++ +  ++   + +  LE +     + L+++  EL     R 
Sbjct: 1035 EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARI 1094

Query: 267  E-------RLRKEFEATTLRVRKLEENIEAERAAH-----LESKFNSEI--IQLRIRDLE 312
            E       +L+K+ +    R+ +LEE +EAER A      L S  + E+  I  R+ +  
Sbjct: 1095 EDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG 1154

Query: 313  GALQVEKASQAEAVADLEIIKNEFKEVESAYE------REKHNAQESFAKLNLLEKEYFS 366
            GA  V+     +  A+ + ++ + +E    +E      R+KH   +S A+L         
Sbjct: 1155 GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH--ADSVAELGEQIDNLQR 1212

Query: 367  KNKKLNEDIEEQKKVIIDLSKRLQY-------NEKSCSELQEELVMAKKHQAFLVETCEN 419
              +KL ++  E K  + D++  ++         EK C  L++++    +H++   ET + 
Sbjct: 1213 VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQM---NEHRSKAEET-QR 1268

Query: 420  NVKELESILDSF-TVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLED----ASN 474
            +V +L S      T +G+ +  + + +        ++ +L R    Y  +LED       
Sbjct: 1269 SVNDLTSQRAKLQTENGELSRQLDEKE-------ALISQLTRGKLTYTQQLEDLKRQLEE 1321

Query: 475  EEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNV 534
            E KA N L    Q        ++E  ++  +   EL  + +K A+ E      K E   +
Sbjct: 1322 EVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSK-ANSEVAQWRTKYETDAI 1380

Query: 535  LHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKF 594
                E E+A+        +KL+Q   ++AEE +  ++       A C  +++ +      
Sbjct: 1381 QRTEELEEAK--------KKLAQRL-QEAEEAVEAVN-------AKCSSLEKTKHR---- 1420

Query: 595  SWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIK 654
                    LQ  ++ L+ D+ R+N     L+   +N    + E +Q  E++ +++    K
Sbjct: 1421 --------LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472

Query: 655  AQESCWHRQKKELELQYSELF--LEVQKRAQK-FQEIAEKNMEKLNHIEKSHEQLVLENS 711
               S    +  +L+  Y E    LE  KR  K  QE      E+L    K+  +L     
Sbjct: 1473 EARSL-STELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHEL----- 1526

Query: 712  HFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEI-R 770
              +K+  Q + E+M L +A          L     +L  +   +      F   K EI R
Sbjct: 1527 --EKVRKQLEAEKMELQSA----------LEEAEASLEHEEGKILRAQLEFNQIKAEIER 1574

Query: 771  TLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMES 830
             LA+        K EE +  K+                   N L+++     SL     S
Sbjct: 1575 KLAE--------KDEEMEQAKR-------------------NHLRVVDSLQTSLDAETRS 1607

Query: 831  FKEGIGML------VCTGEPQDKH--KFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAE 882
              E + +       +   E Q  H  +     ++Q++ LQ+L           +  +  +
Sbjct: 1608 RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSL-----------LKDTQIQ 1656

Query: 883  LQDVIGKADPNSRICGHLLIGAAKNSFAKL-MDKISLVMECIPLHSSRSITYVEKDSL-V 940
            L D +     N  +  ++ I   +N+  +  ++++  V+E     + RS    E++ +  
Sbjct: 1657 LDDAV---RANDDLKENIAIVERRNNLLQAELEELRAVVE----QTERSRKLAEQELIET 1709

Query: 941  QRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEF 1000
                  LH  NT  +    +    +    + LQ ++    Q    AE + +     +T+ 
Sbjct: 1710 SERVQLLHSQNTSLINQKKK----MDADLSQLQTEVEEAVQECRNAEEKAKK---AITDA 1762

Query: 1001 KRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQA 1060
                 E+KKE D +  L+              +  E   ++L + L  +E  Q+ L    
Sbjct: 1763 AMMAEELKKEQDTSAHLERM-----------KKNMEQTIKDLQHRL--DEAEQIALKGGK 1809

Query: 1061 QQLQELNYKL-ELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDK 1119
            +QLQ+L  ++ EL +  EA++ +   E+VK + +++  ++       +  ++L +L+   
Sbjct: 1810 KQLQKLEARVRELENELEAEQKRN-AESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLV 1868

Query: 1120 RRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASR 1170
             +L+  +   +     A +      +  R V++ L +  ++  ++ S  ++
Sbjct: 1869 DKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNK 1919



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 128/654 (19%), Positives = 271/654 (41%), Gaps = 59/654 (9%)

Query: 62   SYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNS 121
            +Y  Q+  L+ ++E+    + +L + L  AR +  L R   EE       +Q  L   NS
Sbjct: 1307 TYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1366

Query: 122  EL-QAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTL 180
            E+ Q +T     A Q +++  +E  ++    L+E +  ++  N +   L K K RL+  +
Sbjct: 1367 EVAQWRTKYETDAIQRTEEL-EEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEI 1425

Query: 181  QEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEK 240
            ++ +   +R      S+    AL++ +   ++  AE ++     +E  + +++  K+   
Sbjct: 1426 EDLMVDVER------SNAAAAALDKKQRNFDKILAEWKQK---YEESQSELESSQKEARS 1476

Query: 241  LETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFN 300
            L TE     +        LE   +  + L++E    T ++    + I        + +  
Sbjct: 1477 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE 1536

Query: 301  SEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAK-LNL 359
               +Q  + + E +L+ E+     A  +   IK E +   +  + E   A+ +  + ++ 
Sbjct: 1537 KMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDS 1596

Query: 360  LEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCEN 419
            L+    ++ +  NE +  +KK+  DL+               E+ +   H   +    + 
Sbjct: 1597 LQTSLDAETRSRNEALRVKKKMEGDLN---------------EMEIQLSHANRMAAEAQK 1641

Query: 420  NVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLER---LRRTLTDYQNKLEDASNEE 476
             VK L+S+L    +  Q    +  + D   + ++V  R   L+  L + +  +E      
Sbjct: 1642 QVKSLQSLLKDTQI--QLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR 1699

Query: 477  K-ACNELDSTKQKID-SHTKNI------KELQDKLADVNKELSHLHTKCADREALISTLK 528
            K A  EL  T +++   H++N       K++   L+ +  E+     +C + E       
Sbjct: 1700 KLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAI 1759

Query: 529  VELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPE 588
             +   +    +KE+  +A  E   + + Q   KD + +L     +   L  G   +++ E
Sbjct: 1760 TDAAMMAEELKKEQDTSAHLERMKKNMEQTI-KDLQHRLDEAEQI--ALKGGKKQLQKLE 1816

Query: 589  GMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTK 648
              + +   +EL A  + N ++ +  + ++  +I+ L Y  +     +  LQ    D   K
Sbjct: 1817 ARVRELE-NELEAEQKRNAES-VKGMRKSERRIKELTYQTEEDRKNLLRLQ----DLVDK 1870

Query: 649  VAEQIKAQESCWHRQKKELELQYS---ELFLEVQ---KRAQKFQEIAEKNMEKL 696
            +  ++KA    + RQ +E E Q +     F +VQ     A++  +IAE  + KL
Sbjct: 1871 LQLKVKA----YKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1920



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 174/893 (19%), Positives = 340/893 (38%), Gaps = 172/893 (19%)

Query: 335  EFKEVESAYEREKHNA--QESFAKLNLLEKEYFSKNKKLNEDIEEQKKVII----DLSKR 388
            + K +  + EREK  A  +E F +L    KE   K++   +++EE+   ++    DL  +
Sbjct: 835  KIKPLLKSAEREKEMASMKEEFTRL----KEALEKSEARRKELEEKMVSLLQEKNDLQLQ 890

Query: 389  LQYNEKSCSELQEELVMAKKHQAFLVETCENNVKEL-ESILDSFTVSGQWTSGIHKDKDK 447
            +Q  + + ++ +E      K++  L    E  VKE+ E + D   ++ + T+   K +D+
Sbjct: 891  VQAEQDNLADAEERCDQLIKNKIQL----EAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946

Query: 448  PPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVN 507
                      L+R + D +  L     E+ A      T+ K+ + T+ +  L + +A + 
Sbjct: 947  -------CSELKRDIDDLELTLAKVEKEKHA------TENKVKNLTEEMAGLDEIIAKLT 993

Query: 508  KE---LSHLHTKCAD----REALISTL---KVELQNVLHCWEKEKAQAAQSESELQKLSQ 557
            KE   L   H +  D     E  ++TL   KV+L+  +   E    Q  +   +L++  +
Sbjct: 994  KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKR 1053

Query: 558  AFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRA 617
                D   KLT                   E ++D  +  +    L E +     +LN  
Sbjct: 1054 KLEGDL--KLT------------------QESIMDLENDKQQ---LDERLKKKDFELNAL 1090

Query: 618  NEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLE 677
            N +I   + +       ++ELQ   E+    + E+++A+ +     + ++E   S+L  E
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEE----LEEELEAERTA----RAKVEKLRSDLSRE 1142

Query: 678  VQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGA 737
            +++ +++ +E       ++   +K         + F+K+    +   +   A  A    A
Sbjct: 1143 LEEISERLEEAGGATSVQIEMNKK-------REAEFQKMRRDLEEATLQHEATAA----A 1191

Query: 738  LYPLYSRSCA-LSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKG 796
            L   ++ S A L  Q D LQ      E  K E +     L  V    ++  K K    K 
Sbjct: 1192 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL---ELDDVTSNMEQIIKAKANLEK- 1247

Query: 797  LIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKE 856
                              + L        +  E  +  +  L        + K      E
Sbjct: 1248 ----------------MCRTLEDQMNEHRSKAEETQRSVNDLT-----SQRAKLQTENGE 1286

Query: 857  QLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKI 916
              R L     L S  L    ++   +L+D+  + +   +         AKN+ A  +   
Sbjct: 1287 LSRQLDEKEALISQ-LTRGKLTYTQQLEDLKRQLEEEVK---------AKNALAHALQ-- 1334

Query: 917  SLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQI 976
            S   +C  L       Y E+      L   L K N+   ++  +      + T  L++  
Sbjct: 1335 SARHDCDLLREQ----YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1390

Query: 977  LGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDK-----------AQGLQMQLNEFK 1025
                QRL  AE    ++  + +  +++ + ++ E++            A  L  +   F 
Sbjct: 1391 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD 1450

Query: 1026 QSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLG 1085
            +      +K+E +  EL ++   +++A+ L  E  +        LE H      +N+ L 
Sbjct: 1451 KILAEWKQKYEESQSELESS---QKEARSLSTELFKLKNAYEESLE-HLETFKRENKNLQ 1506

Query: 1086 EAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESAL------------ 1133
            E +  L+E   +L    +++ +L +   QLE +K  L+  + +AE++L            
Sbjct: 1507 EEISDLTE---QLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL 1563

Query: 1134 -----------RMAAKDKE---CVANHMRAVENTLHKVRDQISLSWSAASRND 1172
                       ++A KD+E      NH+R V++       Q SL     SRN+
Sbjct: 1564 EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSL------QTSLDAETRSRNE 1610



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 71/314 (22%), Positives = 119/314 (37%), Gaps = 65/314 (20%)

Query: 965  ITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQG---LQMQL 1021
            + K    LQ +I    + L A    R  +    ++  R + E+ + L++A G   +Q+++
Sbjct: 1104 LQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1163

Query: 1022 NEFKQSKLITHEK-FESAC--EELNNALLREEQAQML--LNEQAQQLQELNYKLELHSSE 1076
            N+ ++++     +  E A    E   A LR++ A  +  L EQ   LQ +  KLE     
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE----- 1218

Query: 1077 EADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMA 1136
                        K  SE K+EL     ++ Q+ +    LE+  R LE+ +++        
Sbjct: 1219 ------------KEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNE-------- 1258

Query: 1137 AKDKECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGPEV 1196
                     H    E T   V             ND T Q  KL  E   +       E 
Sbjct: 1259 ---------HRSKAEETQRSV-------------NDLTSQRAKLQTENGELSRQLDEKEA 1296

Query: 1197 VACQAMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTA-CLRE--------NA 1247
            +  Q          QL   +   LE+E+ +  +   AL+S  H    LRE         A
Sbjct: 1297 LISQLTRGKLTYTQQLEDLK-RQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 1355

Query: 1248 SLQSIGSRDHSNLS 1261
             LQ + S+ +S ++
Sbjct: 1356 ELQRVLSKANSEVA 1369


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  117 bits (294), Expect = 6e-26
 Identities = 259/1210 (21%), Positives = 492/1210 (40%), Gaps = 165/1210 (13%)

Query: 23   KQILKNETELDITDNLRKKL---HWA------KKEKLEITTKHNAELASYESQIAKLRSE 73
            K + + E+   I  N+R  +   HW       K + L  + +   E+A+ + +  K + E
Sbjct: 804  KMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDE 863

Query: 74   VEKGEALRQSLEYDLAVARKEAG---LGRRAAEERLAEAHRIQEKLCAQNSELQAKTNE- 129
            + K EA R+ LE  L    +E     L  +A  E L +A    ++L     +L+AK  E 
Sbjct: 864  LAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEV 923

Query: 130  TEKA---------FQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTL 180
            TE+A             ++K ++EC   + D+++ +  +    +E      +   L + L
Sbjct: 924  TERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEL 983

Query: 181  Q---EALEKHQREKNEMESHIRETALEEFRLQEEQWEA---ERRELQFIVQEQDTAVQNM 234
                E + K  REK  ++    + AL++ + +E++  +    + +L+  V++ +++++  
Sbjct: 984  SGLDETIAKLTREKKALQE-AHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQE 1042

Query: 235  HKKVEKLETEHMDCS-DLLRRQTSELEFST---QREERLRK-EFEATTLRVRKLEENIEA 289
             K    LE        DL   Q S L+      Q +ERL+K +FE       +L+  +E 
Sbjct: 1043 KKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYC-----QLQSKVED 1097

Query: 290  ERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHN 349
            E+   L+ +   + +Q RI +LE  ++ E+A++A+          E +E+    E     
Sbjct: 1098 EQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGV 1157

Query: 350  AQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEEL------ 403
                       E E+    + L E   + + ++  L K+   +  S +EL E++      
Sbjct: 1158 TSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKK---HADSVAELGEQIDNLQRV 1214

Query: 404  --VMAKKHQAFLVETCENNVKELESILDS--------FTVSGQWTSGIHKDKDKPPSFSV 453
               + K+   F +E  ++    +ES+  S         T+  Q +    K+++   S S 
Sbjct: 1215 KQKLEKEKSEFKLE-IDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSE 1273

Query: 454  VLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSH- 512
            +  +  R  T+          +E   ++L  +KQ     T+ +K   ++       L+H 
Sbjct: 1274 LTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHA 1333

Query: 513  LHTKCADREALISTL------KVELQNVLHCWEKEKAQ--------AAQSESELQ----K 554
            L +   D + L          K ELQ  L     E AQ        A Q   EL+    K
Sbjct: 1334 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1393

Query: 555  LSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADL 614
            L+Q   +D+EE++  ++       A C  +++ +              LQ  V+ L+ D+
Sbjct: 1394 LAQRL-QDSEEQVEAVN-------AKCASLEKTKQR------------LQGEVEDLMVDV 1433

Query: 615  NRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSEL 674
             RAN     L+   +N    + E +   E++  ++   +K   S    +  +L+  Y E 
Sbjct: 1434 ERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSL-STELFKLKNAYEEA 1492

Query: 675  F--LEVQKRAQK--FQEIAE------KNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQ 724
               LE  KR  K   QEIA+      +N + ++ +EKS +Q+ LE +  +  L + +   
Sbjct: 1493 LDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAAL 1552

Query: 725  MSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQ 784
                A    +   L  + S       ++D   EQ+     ++  + T+  AL      + 
Sbjct: 1553 EHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLK--RNYQRTVETMQSALDAEVRSRN 1610

Query: 785  EEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTG-E 843
            E  ++KKK    L  I     I +  ANR     Q+  +L    +  +   G L  T   
Sbjct: 1611 EAIRLKKKMEGDLNEI----EIQLSHANR-----QAAETL----KHLRSVQGQLKDTQLH 1657

Query: 844  PQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIG 903
              D  +  +  KEQL  ++  + L             AE++++    +   R        
Sbjct: 1658 LDDALRGQEDLKEQLAIVERRANLL-----------QAEVEELRATLEQTER-------- 1698

Query: 904  AAKNSFAKLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHV 963
            A K +  +L+D    V      ++S   T  + ++ + +L   +   +  A     +   
Sbjct: 1699 ARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKK 1758

Query: 964  PITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNE 1023
             IT   A++  + L   Q   A  +ER    LE T     V +++  LD+A+ L ++  +
Sbjct: 1759 AIT--DAAMMAEELKKEQDTSA-HLERMKKNLEQT-----VKDLQHRLDEAEQLALKGGK 1810

Query: 1024 FKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKN-Q 1082
             +  KL T  +      EL     +  ++   L +  ++++EL Y+     SEE  KN  
Sbjct: 1811 KQIQKLET--RIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQ-----SEEDRKNVL 1863

Query: 1083 TLGEAVKSLS-EAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESA----LRMAA 1137
             L + V  L  + K   R+ +++  Q N HLT+  + +  LEE    A+ A     ++ A
Sbjct: 1864 RLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRA 1923

Query: 1138 KDKECVANHM 1147
            K ++  ++ M
Sbjct: 1924 KTRDFTSSRM 1933



 Score =  109 bits (272), Expect = 2e-23
 Identities = 215/1074 (20%), Positives = 441/1074 (41%), Gaps = 139/1074 (12%)

Query: 126  KTNETEKAFQTSQ---QKWKEECRRFEHDLEE-RDNMIQNCNREYDLLMKEKSRLEKTL- 180
            K+ ETEK   T +   QK K+E  + E   +E  + ++     + DL ++ ++  E  L 
Sbjct: 842  KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901

Query: 181  -QEALEKHQREKNEMESHIRETALEEFRLQEE---QWEAERRELQFIVQEQDTAVQNMHK 236
             +E  ++  + K ++E+ I+E   E    +EE   +  A++R+L+    E    + ++  
Sbjct: 902  AEERCDQLIKAKFQLEAKIKEVT-ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 960

Query: 237  KVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLE 296
             + K+E E     + ++  T EL    +   +L +E +A     ++  ++++AE     E
Sbjct: 961  TLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE-----E 1015

Query: 297  SKFNS-----EIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQ 351
             K NS       ++ ++ DLE +L+ EK  + +   +   ++ + K  + +    +++ Q
Sbjct: 1016 DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQ 1075

Query: 352  ESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQA 411
            +   +L   + EY     +L   +E+++ + +   K+++  +    EL+EE+   +  +A
Sbjct: 1076 QLDERLKKKDFEYC----QLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRA 1131

Query: 412  FLVETCENNVKELESILDSFTVSGQWTSG-IHKDKDKPPSFSVVLERLRRTLTD--YQNK 468
               +   +  +ELE + +    +G  TS  I  +K +   F     +LRR L +   Q++
Sbjct: 1132 KTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFL----KLRRDLEEATLQHE 1187

Query: 469  LEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLK 528
               A+  +K  + +    ++ID+  +  ++L+ + ++   E+  L +        +S  K
Sbjct: 1188 AMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMES----VSKSK 1243

Query: 529  VELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPE 588
              L+ +    E + ++A     E+Q+             T    L + L       ++ E
Sbjct: 1244 ANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQL-------EEKE 1296

Query: 589  GMLDKFSWSELCAVLQ-ENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQED--- 644
             ++ + S S+     Q E +   + + N+A   + H     ++  D +RE  + +++   
Sbjct: 1297 SIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKA 1356

Query: 645  TFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKR-AQKFQEIAEKNMEKLN----HI 699
               +   +  ++ + W  + +   +Q +E   E +K+ AQ+ Q+ +E+ +E +N     +
Sbjct: 1357 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD-SEEQVEAVNAKCASL 1415

Query: 700  EKSHEQL----------VLENSHFKKLLSQTQREQMSLLAA----CALMAGALYPLYSRS 745
            EK+ ++L          V   +     L + QR    +LA     C      L      S
Sbjct: 1416 EKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKES 1475

Query: 746  CALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKG- 804
             +LST            ELFKL+     +AL  +E  K+E   ++++      +I   G 
Sbjct: 1476 RSLST------------ELFKLK-NAYEEALDQLETVKRENKNLEQEIADLTEQIAENGK 1522

Query: 805  VIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQAL 864
             I  L  +R +I            E  K  I + +   E   +H+  K  + QL   Q  
Sbjct: 1523 TIHELEKSRKQI------------ELEKADIQLALEEAEAALEHEEAKILRIQLELTQVK 1570

Query: 865  SWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGA------AKNSFAKLMDKISL 918
            S          I   +AE  + I +   N +     +  A      ++N   +L  K+  
Sbjct: 1571 S---------EIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEG 1621

Query: 919  VMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILG 978
             +  I +  S +     +     R   G  K   L L   LRG   + +  A ++++   
Sbjct: 1622 DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRA-- 1679

Query: 979  FTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESA 1038
                L  AEVE     LE TE  R + E +  LD  + +Q+ L+    S + T +K E+ 
Sbjct: 1680 ---NLLQAEVEELRATLEQTERARKLAEQEL-LDSNERVQL-LHTQNTSLIHTKKKLET- 1733

Query: 1039 CEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMEL 1098
                                    L +L  ++E  S +  +  +   +A+   +    EL
Sbjct: 1734 -----------------------DLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEEL 1770

Query: 1099 RRKDQSLRQLNRHLTQLEQDKRRLEENIHDAES-ALRMAAKDKECVANHMRAVE 1151
            +++  +   L R    LEQ  + L+  + +AE  AL+   K  + +   +R +E
Sbjct: 1771 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELE 1824



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 191/990 (19%), Positives = 394/990 (39%), Gaps = 142/990 (14%)

Query: 210  EEQWEAERRELQFIVQEQDTAVQNM-HKKVEKLETEHMDCSDLLRRQTSELEFSTQREER 268
            E Q   +RRE  F +Q    +  N+ H    KL         LL+   +E E +T +EE 
Sbjct: 801  EFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKL---FFKIKPLLKSAETEKEMATMKEE- 856

Query: 269  LRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVAD 328
                F+ T   + K E      +   LE K  + + +     L+   + E    AE   D
Sbjct: 857  ----FQKTKDELAKSEA-----KRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCD 907

Query: 329  LEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKR 388
             ++IK +F ++E+  +     A++       +  E  +K +KL ++  E KK I DL   
Sbjct: 908  -QLIKAKF-QLEAKIKEVTERAEDE----EEINAELTAKKRKLEDECSELKKDIDDLELT 961

Query: 389  LQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKP 448
            L   EK     + ++    +  + L ET     +E +++ ++     Q    +  ++DK 
Sbjct: 962  LAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQ---QALDDLQAEEDKV 1018

Query: 449  PSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNK 508
             S +    +L + + D ++ LE    E+K   +L+  K+K++    ++K  Q+ + D+  
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLEQ---EKKLRVDLERNKRKLEG---DLKLAQESILDLEN 1072

Query: 509  ELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLT 568
                      D++ L   LK +        + E  Q      + Q L   F K  +E   
Sbjct: 1073 ----------DKQQLDERLKKK--------DFEYCQLQSKVEDEQTLGLQFQKKIKELQA 1114

Query: 569  FLHTLYQHLVAGCVLIKQPEGMLDKFS--WSELCAVLQE--NVDALIADLNRANE----K 620
             +  L + + A      + E     ++    EL   L+E   V +   +LN+  E    K
Sbjct: 1115 RIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLK 1174

Query: 621  IRH-LEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQ 679
            +R  LE         +  L++   D+  ++ EQI   +    R K++LE + SE  LE+ 
Sbjct: 1175 LRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQ----RVKQKLEKEKSEFKLEID 1230

Query: 680  KRAQKFQEIAEK--NMEKL-NHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAG 736
              +   + +++   N+EK+   +E    +   +N   ++ LS+   ++  L      ++ 
Sbjct: 1231 DLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSR 1290

Query: 737  ALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKG 796
             L    S    LS  +    +Q    +    E      AL+   +  + +  + ++ ++ 
Sbjct: 1291 QLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEE 1350

Query: 797  LIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKE 856
                 ++G      A   + L ++ + +  W   ++        T   Q   +  + +K+
Sbjct: 1351 E----QEG-----KAELQRALSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKK 1393

Query: 857  QLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGH---LLIGAAK-NSFAKL 912
              + LQ      S + + A+ +  A L+          R+ G    L++   + NS A  
Sbjct: 1394 LAQRLQ-----DSEEQVEAVNAKCASLEKT------KQRLQGEVEDLMVDVERANSLAAA 1442

Query: 913  MDKISLVMECI-----------------PLHSSRSITYVEKDSLVQRLAHGLHKVNTLAL 955
            +DK     + +                  L  SRS++  E   L       L ++ T+  
Sbjct: 1443 LDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLS-TELFKLKNAYEEALDQLETVK- 1500

Query: 956  KYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELD--K 1013
                R +  + +  A L +QI    + +H  E  R+ + LE  + + ++ E +  L+  +
Sbjct: 1501 ----RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEE 1556

Query: 1014 AQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELH 1073
            A+ L++QL E  Q K            E++  +  ++       E+ +QL+  NY+  + 
Sbjct: 1557 AKILRIQL-ELTQVK-----------SEIDRKIAEKD-------EEIEQLKR-NYQRTVE 1596

Query: 1074 SSEEA--DKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAES 1131
            + + A   + ++  EA++   + + +L   +  L   NR   +  +  R ++  + D + 
Sbjct: 1597 TMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL 1656

Query: 1132 ALRMAAKDKECVANHMRAVENTLHKVRDQI 1161
             L  A + +E +   +  VE   + ++ ++
Sbjct: 1657 HLDDALRGQEDLKEQLAIVERRANLLQAEV 1686



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 180/889 (20%), Positives = 343/889 (38%), Gaps = 162/889 (18%)

Query: 315  LQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYF---SKNKKL 371
            L   +A + E    L  +  E  +++   + E  N  ++  + + L K  F   +K K++
Sbjct: 864  LAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEV 923

Query: 372  NEDIEEQKKVIIDLSKRLQYNEKSCSELQE-----ELVMAKKHQAFLVETCENNVKELES 426
             E  E+++++  +L+ + +  E  CSEL++     EL +AK  +       EN VK L  
Sbjct: 924  TERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE--KHATENKVKNLTE 981

Query: 427  ILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTD-YQNKLEDASNEEKACNELDST 485
             L          SG+ +   K       L R ++ L + +Q  L+D   EE   N L+ T
Sbjct: 982  EL----------SGLDETIAK-------LTREKKALQEAHQQALDDLQAEEDKVNSLNKT 1024

Query: 486  KQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQA 545
            K K++   + +++L+  L    K                  L+V+L+      E +   A
Sbjct: 1025 KSKLE---QQVEDLESSLEQEKK------------------LRVDLERNKRKLEGDLKLA 1063

Query: 546  AQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQE 605
             +S  +L+   Q   +  ++K  F +   Q  V      +Q  G+  +    EL A ++E
Sbjct: 1064 QESILDLENDKQQLDERLKKK-DFEYCQLQSKVED----EQTLGLQFQKKIKELQARIEE 1118

Query: 606  NVDALIAD-LNRANEKIRHLEYICKNKSDTMRELQQTQED-------TFTKVAEQIKAQE 657
              + + A+   RA  +        K +SD  REL++  E        T T++ E  K +E
Sbjct: 1119 LEEEIEAERATRAKTE--------KQRSDYARELEELSERLEEAGGVTSTQI-ELNKKRE 1169

Query: 658  SCWHRQKKELE---LQYSELFLEVQKR-AQKFQEIAEK--NMEKLNH-IEKSHEQLVLEN 710
            + + + +++LE   LQ+  +   ++K+ A    E+ E+  N++++   +EK   +  LE 
Sbjct: 1170 AEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEI 1229

Query: 711  SHFKKLLSQTQREQMSLLAACALMAGALYPLYSRS-------CALSTQRDFLQEQVNTFE 763
                  +    + + +L   C  +   L     ++         L+TQ+  LQ +     
Sbjct: 1230 DDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELS 1289

Query: 764  LFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCAS 823
                  R L +  S V +  + +    ++T +   ++  +       A+ L+     C  
Sbjct: 1290 ------RQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDL 1343

Query: 824  LFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAEL 883
            L    E  +EG   L        +    K   E         W T  +  A  I    EL
Sbjct: 1344 LREQYEEEQEGKAEL--------QRALSKANSE------VAQWRTKYETDA--IQRTEEL 1387

Query: 884  QDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKDSLVQRL 943
            ++                  A K    +L D    V       +S   T       V+ L
Sbjct: 1388 EE------------------AKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDL 1429

Query: 944  AHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRS 1003
               + + N+LA               A+L K+   F + L  AE +        T+ + S
Sbjct: 1430 MVDVERANSLA---------------AALDKKQRNFDKVL--AEWK--------TKCEES 1464

Query: 1004 VNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQML--LNEQAQ 1061
              E++  L +++ L  +L + K +     ++ E+   E  N  L +E A +   + E  +
Sbjct: 1465 QAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKN--LEQEIADLTEQIAENGK 1522

Query: 1062 QLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLT-------- 1113
             + EL    +    E+AD    L EA  +L   + ++ R    L Q+   +         
Sbjct: 1523 TIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDE 1582

Query: 1114 QLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQIS 1162
            ++EQ KR  +  +   +SAL    + +       + +E  L+++  Q+S
Sbjct: 1583 EIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLS 1631



 Score = 39.3 bits (90), Expect = 0.025
 Identities = 64/284 (22%), Positives = 116/284 (40%), Gaps = 27/284 (9%)

Query: 994  RLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQ 1053
            RL+  +F+    + K E ++  GLQ Q    +    I   + E   E    A   ++++ 
Sbjct: 1080 RLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSD 1139

Query: 1054 ML--LNEQAQQLQEL----NYKLELHSSEEAD---KNQTLGEAVKSLSEAKMELRRKD-Q 1103
                L E +++L+E     + ++EL+   EA+     + L EA          LR+K   
Sbjct: 1140 YARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD 1199

Query: 1104 SLRQLNRHLTQLEQDKRRLEE-------NIHDAESALRMAAKDKECVANHMRAVENTLHK 1156
            S+ +L   +  L++ K++LE+        I D  S++   +K K  +    R +E+ L +
Sbjct: 1200 SVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSE 1259

Query: 1157 VR---DQISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQLA 1213
             R   ++I  S S     + T Q  +L  E   +       E +  Q + +S     Q  
Sbjct: 1260 ARGKNEEIQRSLS-----ELTTQKSRLQTEAGELSRQLEEKESIVSQ-LSRSKQAFTQQT 1313

Query: 1214 STRIMTLEKEMTSHRSHIAALKSELHTA-CLRENASLQSIGSRD 1256
                  LE+E  +  +   AL+S  H    LRE    +  G  +
Sbjct: 1314 EELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAE 1357



 Score = 34.3 bits (77), Expect = 0.82
 Identities = 24/137 (17%), Positives = 58/137 (42%), Gaps = 7/137 (5%)

Query: 1033 EKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLS 1092
            E+F+   +EL  +  + ++ +  L    Q+  +L  +++  S    D  +   + +K+  
Sbjct: 855  EEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKF 914

Query: 1093 EAKMELRRKDQSLRQLNRHLTQLEQDKRRLEE-------NIHDAESALRMAAKDKECVAN 1145
            + + +++   +          +L   KR+LE+       +I D E  L    K+K    N
Sbjct: 915  QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 974

Query: 1146 HMRAVENTLHKVRDQIS 1162
             ++ +   L  + + I+
Sbjct: 975  KVKNLTEELSGLDETIA 991


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  115 bits (287), Expect = 4e-25
 Identities = 238/1221 (19%), Positives = 485/1221 (39%), Gaps = 183/1221 (14%)

Query: 23   KQILKNETELDITDNLRKKL---HWA------KKEKLEITTKHNAELASYESQIAKLRSE 73
            + + + E    I  N+R  +   HW       K + L  + +   E+A+ + +  K++ E
Sbjct: 809  RMVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDE 868

Query: 74   VEKGEALRQSLEYDLAVARKEAG---LGRRAAEERLAEAHRIQEKLCAQNSELQAKTNE- 129
            + K EA R+ LE  +    KE     L  +A  E LA+A    ++L     +L+AK  E 
Sbjct: 869  LAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEV 928

Query: 130  TEKA---------FQTSQQKWKEECRRFEHDLEE--------------RDNMIQNCNREY 166
            TE+A             ++K ++EC   + D+++               +N ++N   E 
Sbjct: 929  TERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM 988

Query: 167  DLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQE 226
              L +  ++L K  +   E HQ+  +++++   E  +      + + E +  +L+  +++
Sbjct: 989  AGLDETIAKLTKEKKALQEAHQQTLDDLQAE--EDKVNTLTKAKIKLEQQVDDLEGSLEQ 1046

Query: 227  QDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEEN 286
            +     ++ +   KLE       DL   Q S ++   ++++ L ++ +     +  L+  
Sbjct: 1047 EKKLRMDLERAKRKLE------GDLKLAQESIMDIENEKQQ-LDEKLKKKEFEISNLQSK 1099

Query: 287  IEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYERE 346
            IE E+A  ++ +   + +Q RI +LE  ++ E+AS+A+A      +  E +E+    E E
Sbjct: 1100 IEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLE-E 1158

Query: 347  KHNAQESFAKLNLLEKEYFSK-------------------NKKLNEDIEEQKKVIIDLSK 387
               A  +  ++N   +  F K                    KK  + + E  + I +L +
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218

Query: 388  RLQYNEKSCSELQ----------EELVMAKKHQAFLVETCENNVKELES-------ILDS 430
              Q  EK  SE++          E +  AK +   +  T E+ + EL+S       +++ 
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278

Query: 431  FTV--------SGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKA-CNE 481
             T         SG+++  + + +      S   +   + + + + +LE+    + A  + 
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338

Query: 482  LDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKE 541
            L S++   D   +  +E Q+  A++ + LS  +T+ A       T  ++    L   +K+
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKK 1398

Query: 542  KAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCA 601
             AQ  Q+  E  +   A     E+    L    + L            MLD    +  CA
Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL------------MLDVERTNAACA 1446

Query: 602  VL---QENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQES 658
             L   Q N D ++A+  +  E+  H E     K    R L  T+        E+   Q  
Sbjct: 1447 ALDKKQRNFDKILAEWKQKCEE-THAELEASQKE--ARSL-GTELFKIKNAYEESLDQLE 1502

Query: 659  CWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLS 718
               R+ K L+ + S+L  ++ +  ++  E+  + ++K    EK   Q  LE +      +
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHEL--EKIKKQVEQEKCELQAALEEAE-----A 1555

Query: 719  QTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALST 778
              + E+  +L            L          R   ++     +L +  IR +    ST
Sbjct: 1556 SLEHEEGKILR---------IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606

Query: 779  V--EEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIG 836
            +  E + + +A   KK  +G +       I +  ANR+             + +++   G
Sbjct: 1607 LDAEIRSRNDAIRLKKKMEGDLNEME---IQLNHANRMAAEA---------LRNYRNTQG 1654

Query: 837  MLVCTG-EPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSR 895
            +L  T     D  +  +  KEQL  ++  + L  +++         EL+  + + + + +
Sbjct: 1655 ILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI--------EELRATLEQTERSRK 1706

Query: 896  ICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLAL 955
            I    L+ A++          SL+     L +  S    E + ++Q   +   K      
Sbjct: 1707 IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAI- 1765

Query: 956  KYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQ 1015
                        + A++  + L   Q   +A +ER    +E T     V +++  LD+A+
Sbjct: 1766 ------------TDAAMMAEELKKEQDT-SAHLERMKKNMEQT-----VKDLQLRLDEAE 1807

Query: 1016 GLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSS 1075
             L ++  + +  KL    +      E+ +   R  +A   L +  ++++EL Y+ E    
Sbjct: 1808 QLALKGGKKQIQKL--EARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTE---- 1861

Query: 1076 EEADKNQTLGEAVKSL-SEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALR 1134
            E+      L + V  L ++ K   R+ +++  Q N +L +     R+L+  + +AE    
Sbjct: 1862 EDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKF----RKLQHELEEAEERAD 1917

Query: 1135 MAAKDKECVANHMRAVENTLH 1155
            +A    E   N +R     +H
Sbjct: 1918 IA----ESQVNKLRVKSREVH 1934



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 99/429 (23%), Positives = 182/429 (42%), Gaps = 60/429 (13%)

Query: 19   SLDVKQILKNETE------LDITDNLR---KKLHWAKKEKLEITTKHNAELASYESQIAK 69
            SLD  + LK E +       D+T+ +    K++H  +K K ++  +     A+ E   A 
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556

Query: 70   LRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAE-ERLAEAH-RIQEKLCAQNSELQAKT 127
            L  E E+G+ LR  LE +   +  +  +  +  E ++L   H RI E +    S L A+ 
Sbjct: 1557 L--EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESM---QSTLDAEI 1611

Query: 128  NETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREY----DLLMKEKSRLEKTLQEA 183
                 A +  ++K + +    E  L   + M     R Y     +L   +  L+  L+  
Sbjct: 1612 RSRNDAIRL-KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQ 1670

Query: 184  LE-KHQREKNEMESHIRETALEEFRLQEEQWEAERR----------ELQFIVQEQDTAVQ 232
             + K Q    E  +++ +  +EE R   EQ E  R+          E   ++  Q+T++ 
Sbjct: 1671 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1730

Query: 233  NMHKKVE--------KLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLE 284
            N  KK+E        ++E    +  +   +    +  +    E L+KE + T+  + +++
Sbjct: 1731 NTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKE-QDTSAHLERMK 1789

Query: 285  ENIE------------AERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEII 332
            +N+E            AE+ A    K   + ++ R+R+LEG ++ E+   AEAV  L   
Sbjct: 1790 KNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKH 1849

Query: 333  KNEFKEVESAYEREKHN---AQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRL 389
            +   KE+    E ++ N    Q+   KL    K Y    K+  E+ EEQ    +   ++L
Sbjct: 1850 ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSY----KRQAEEAEEQSNTNLAKFRKL 1905

Query: 390  QYNEKSCSE 398
            Q+  +   E
Sbjct: 1906 QHELEEAEE 1914



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 158/818 (19%), Positives = 299/818 (36%), Gaps = 121/818 (14%)

Query: 422  KELESILDSFT-VSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACN 480
            KE+ ++ + F  +  +      K K+       +L+         Q + E  ++ E+ C+
Sbjct: 853  KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCD 912

Query: 481  ELDSTKQKIDSHTKNIKELQDKLADVNKELS----HLHTKCADREALISTLKVELQNVLH 536
            +L  TK ++++  K + E  +   ++N EL+     L  +C++ +  I  L++ L  V  
Sbjct: 913  QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV-- 970

Query: 537  CWEKEKAQAAQS----ESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLD 592
              EKEK            E+  L +   K  +EK        Q L      ++  E  ++
Sbjct: 971  --EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD----LQAEEDKVN 1024

Query: 593  KFSWSELCAVLQENVDALIA----------DLNRANEKIR-HLEYICKNKSDTMRELQQT 641
              + +++   L++ VD L            DL RA  K+   L+   ++  D   E QQ 
Sbjct: 1025 TLTKAKI--KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQL 1082

Query: 642  QEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEK 701
             E    K  E    Q      Q   ++LQ  +   E+Q R ++ +E  E         EK
Sbjct: 1083 DEKLKKKEFEISNLQSKIEDEQALGIQLQ--KKIKELQARIEELEEEIEAERASRAKAEK 1140

Query: 702  SHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNT 761
                L  E     + L     E+     +  +          +      +   LQ +   
Sbjct: 1141 QRSDLSRELEEISERL-----EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195

Query: 762  FELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSC 821
              L K    ++A+    ++  ++ + K++K+  +       K  I  LA+N         
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE------MKMEIDDLASN--------- 1240

Query: 822  ASLFTWMESFKEGIGML--VCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISS 879
                  +E+  +  G L  +C        +    ++EQ R +        +DL A     
Sbjct: 1241 ------VETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI--------NDLTAQRGRL 1286

Query: 880  MAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVME---------CIPLHSSRS 930
              E  +   + D    +   L  G  K +F + ++++   +E            L SSR 
Sbjct: 1287 QTESGEFSRQLDEKEALVSQLSRG--KQAFTQQIEELKRQLEEEIKAKNALAHALQSSRH 1344

Query: 931  IT------YVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLH 984
                    Y E+      L   L K NT   ++  +      + T  L++      QRL 
Sbjct: 1345 DCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1404

Query: 985  AAEVERRSLRLEVTEFKRSVNEMKKELD------------------KAQGLQMQLNEFKQ 1026
            AAE    ++  +    +++   ++ E++                  K +     L E+KQ
Sbjct: 1405 AAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQ 1464

Query: 1027 SKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGE 1086
                TH + E++ +E  +      + +    E   QL+ L  + +    E +D  + + E
Sbjct: 1465 KCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAE 1524

Query: 1087 AVKSLSEAKMELRRKDQSLRQLNRHLTQLEQD---------KRRLEENIHDAESALRMAA 1137
              K + E +   ++ +Q   +L   L + E           + +LE N   +E   ++A 
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1584

Query: 1138 KDKE---CVANHMRAVENTLHKVRDQISLSWSAASRND 1172
            KD+E      NH+R VE+       Q +L     SRND
Sbjct: 1585 KDEEIDQLKRNHIRIVESM------QSTLDAEIRSRND 1616



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 58/268 (21%), Positives = 114/268 (42%), Gaps = 16/268 (5%)

Query: 987  EVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNAL 1046
            E ++   +L+  EF+ S  + K E ++A G+Q+Q    +    I   + E   E  + A 
Sbjct: 1078 EKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAK 1137

Query: 1047 LREEQAQML--LNEQAQQLQEL----NYKLELHSSEEAD---KNQTLGEAVKSLSEAKME 1097
              ++++ +   L E +++L+E     + ++E++   EA+     + L EA          
Sbjct: 1138 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1197

Query: 1098 LRRKD-QSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHK 1156
            LR+K   S+ +L   +  L++ K++LE+   + +  +   A + E V+     +E     
Sbjct: 1198 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRT 1257

Query: 1157 VRDQISLSWSAASR-----NDFTLQLPKLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQ 1211
            + DQ+S   S         ND T Q  +L  E+          E +  Q          Q
Sbjct: 1258 LEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQ 1317

Query: 1212 LASTRIMTLEKEMTSHRSHIAALKSELH 1239
            +   +   LE+E+ +  +   AL+S  H
Sbjct: 1318 IEELK-RQLEEEIKAKNALAHALQSSRH 1344



 Score = 34.7 bits (78), Expect = 0.62
 Identities = 58/311 (18%), Positives = 119/311 (38%), Gaps = 62/311 (19%)

Query: 967  KSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELD-KAQGLQMQLNEFK 1025
            K  A+++++       L  +E +R+ L  ++    +  N+++ ++  +A+GL        
Sbjct: 853  KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA------- 905

Query: 1026 QSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKL--------------- 1070
                      E  C++L    ++ E     + E+A+  +E+N +L               
Sbjct: 906  --------DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 957

Query: 1071 ---------------ELHSSEEADKNQT-----LGEAVKSLSEAKMELRRKDQ----SLR 1106
                           E H++E   KN T     L E +  L++ K  L+   Q     L+
Sbjct: 958  KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1017

Query: 1107 QLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWS 1166
                 +  L + K +LE+ + D E +L    K +  +    R +E  L   ++ I    +
Sbjct: 1018 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN 1077

Query: 1167 AASRNDFTLQLPKLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQLASTRIMTLEKEMTS 1226
               + D      KL  + F +  L+   ++   QA+        +    RI  LE+E+ +
Sbjct: 1078 EKQQLD-----EKLKKKEFEISNLQS--KIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130

Query: 1227 HRSHIAALKSE 1237
             R+  A  + +
Sbjct: 1131 ERASRAKAEKQ 1141


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  115 bits (287), Expect = 4e-25
 Identities = 238/1221 (19%), Positives = 485/1221 (39%), Gaps = 183/1221 (14%)

Query: 23   KQILKNETELDITDNLRKKL---HWA------KKEKLEITTKHNAELASYESQIAKLRSE 73
            + + + E    I  N+R  +   HW       K + L  + +   E+A+ + +  K++ E
Sbjct: 809  RMVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDE 868

Query: 74   VEKGEALRQSLEYDLAVARKEAG---LGRRAAEERLAEAHRIQEKLCAQNSELQAKTNE- 129
            + K EA R+ LE  +    KE     L  +A  E LA+A    ++L     +L+AK  E 
Sbjct: 869  LAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEV 928

Query: 130  TEKA---------FQTSQQKWKEECRRFEHDLEE--------------RDNMIQNCNREY 166
            TE+A             ++K ++EC   + D+++               +N ++N   E 
Sbjct: 929  TERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM 988

Query: 167  DLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQE 226
              L +  ++L K  +   E HQ+  +++++   E  +      + + E +  +L+  +++
Sbjct: 989  AGLDETIAKLTKEKKALQEAHQQTLDDLQAE--EDKVNTLTKAKIKLEQQVDDLEGSLEQ 1046

Query: 227  QDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEEN 286
            +     ++ +   KLE       DL   Q S ++   ++++ L ++ +     +  L+  
Sbjct: 1047 EKKLRMDLERAKRKLE------GDLKLAQESIMDIENEKQQ-LDEKLKKKEFEISNLQSK 1099

Query: 287  IEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYERE 346
            IE E+A  ++ +   + +Q RI +LE  ++ E+AS+A+A      +  E +E+    E E
Sbjct: 1100 IEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLE-E 1158

Query: 347  KHNAQESFAKLNLLEKEYFSK-------------------NKKLNEDIEEQKKVIIDLSK 387
               A  +  ++N   +  F K                    KK  + + E  + I +L +
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218

Query: 388  RLQYNEKSCSELQ----------EELVMAKKHQAFLVETCENNVKELES-------ILDS 430
              Q  EK  SE++          E +  AK +   +  T E+ + EL+S       +++ 
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278

Query: 431  FTV--------SGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKA-CNE 481
             T         SG+++  + + +      S   +   + + + + +LE+    + A  + 
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338

Query: 482  LDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKE 541
            L S++   D   +  +E Q+  A++ + LS  +T+ A       T  ++    L   +K+
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKK 1398

Query: 542  KAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCA 601
             AQ  Q+  E  +   A     E+    L    + L            MLD    +  CA
Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL------------MLDVERTNAACA 1446

Query: 602  VL---QENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQES 658
             L   Q N D ++A+  +  E+  H E     K    R L  T+        E+   Q  
Sbjct: 1447 ALDKKQRNFDKILAEWKQKCEE-THAELEASQKE--ARSL-GTELFKIKNAYEESLDQLE 1502

Query: 659  CWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLS 718
               R+ K L+ + S+L  ++ +  ++  E+  + ++K    EK   Q  LE +      +
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHEL--EKIKKQVEQEKCELQAALEEAE-----A 1555

Query: 719  QTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALST 778
              + E+  +L            L          R   ++     +L +  IR +    ST
Sbjct: 1556 SLEHEEGKILR---------IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606

Query: 779  V--EEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIG 836
            +  E + + +A   KK  +G +       I +  ANR+             + +++   G
Sbjct: 1607 LDAEIRSRNDAIRLKKKMEGDLNEME---IQLNHANRMAAEA---------LRNYRNTQG 1654

Query: 837  MLVCTG-EPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSR 895
            +L  T     D  +  +  KEQL  ++  + L  +++         EL+  + + + + +
Sbjct: 1655 ILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI--------EELRATLEQTERSRK 1706

Query: 896  ICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLAL 955
            I    L+ A++          SL+     L +  S    E + ++Q   +   K      
Sbjct: 1707 IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAI- 1765

Query: 956  KYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQ 1015
                        + A++  + L   Q   +A +ER    +E T     V +++  LD+A+
Sbjct: 1766 ------------TDAAMMAEELKKEQDT-SAHLERMKKNMEQT-----VKDLQLRLDEAE 1807

Query: 1016 GLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSS 1075
             L ++  + +  KL    +      E+ +   R  +A   L +  ++++EL Y+ E    
Sbjct: 1808 QLALKGGKKQIQKL--EARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTE---- 1861

Query: 1076 EEADKNQTLGEAVKSL-SEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALR 1134
            E+      L + V  L ++ K   R+ +++  Q N +L +     R+L+  + +AE    
Sbjct: 1862 EDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKF----RKLQHELEEAEERAD 1917

Query: 1135 MAAKDKECVANHMRAVENTLH 1155
            +A    E   N +R     +H
Sbjct: 1918 IA----ESQVNKLRVKSREVH 1934



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 99/429 (23%), Positives = 182/429 (42%), Gaps = 60/429 (13%)

Query: 19   SLDVKQILKNETE------LDITDNLR---KKLHWAKKEKLEITTKHNAELASYESQIAK 69
            SLD  + LK E +       D+T+ +    K++H  +K K ++  +     A+ E   A 
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556

Query: 70   LRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAE-ERLAEAH-RIQEKLCAQNSELQAKT 127
            L  E E+G+ LR  LE +   +  +  +  +  E ++L   H RI E +    S L A+ 
Sbjct: 1557 L--EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESM---QSTLDAEI 1611

Query: 128  NETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREY----DLLMKEKSRLEKTLQEA 183
                 A +  ++K + +    E  L   + M     R Y     +L   +  L+  L+  
Sbjct: 1612 RSRNDAIRL-KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQ 1670

Query: 184  LE-KHQREKNEMESHIRETALEEFRLQEEQWEAERR----------ELQFIVQEQDTAVQ 232
             + K Q    E  +++ +  +EE R   EQ E  R+          E   ++  Q+T++ 
Sbjct: 1671 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1730

Query: 233  NMHKKVE--------KLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLE 284
            N  KK+E        ++E    +  +   +    +  +    E L+KE + T+  + +++
Sbjct: 1731 NTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKE-QDTSAHLERMK 1789

Query: 285  ENIE------------AERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEII 332
            +N+E            AE+ A    K   + ++ R+R+LEG ++ E+   AEAV  L   
Sbjct: 1790 KNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKH 1849

Query: 333  KNEFKEVESAYEREKHN---AQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRL 389
            +   KE+    E ++ N    Q+   KL    K Y    K+  E+ EEQ    +   ++L
Sbjct: 1850 ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSY----KRQAEEAEEQSNTNLAKFRKL 1905

Query: 390  QYNEKSCSE 398
            Q+  +   E
Sbjct: 1906 QHELEEAEE 1914



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 158/818 (19%), Positives = 299/818 (36%), Gaps = 121/818 (14%)

Query: 422  KELESILDSFT-VSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACN 480
            KE+ ++ + F  +  +      K K+       +L+         Q + E  ++ E+ C+
Sbjct: 853  KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCD 912

Query: 481  ELDSTKQKIDSHTKNIKELQDKLADVNKELS----HLHTKCADREALISTLKVELQNVLH 536
            +L  TK ++++  K + E  +   ++N EL+     L  +C++ +  I  L++ L  V  
Sbjct: 913  QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV-- 970

Query: 537  CWEKEKAQAAQS----ESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLD 592
              EKEK            E+  L +   K  +EK        Q L      ++  E  ++
Sbjct: 971  --EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD----LQAEEDKVN 1024

Query: 593  KFSWSELCAVLQENVDALIA----------DLNRANEKIR-HLEYICKNKSDTMRELQQT 641
              + +++   L++ VD L            DL RA  K+   L+   ++  D   E QQ 
Sbjct: 1025 TLTKAKI--KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQL 1082

Query: 642  QEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEK 701
             E    K  E    Q      Q   ++LQ  +   E+Q R ++ +E  E         EK
Sbjct: 1083 DEKLKKKEFEISNLQSKIEDEQALGIQLQ--KKIKELQARIEELEEEIEAERASRAKAEK 1140

Query: 702  SHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNT 761
                L  E     + L     E+     +  +          +      +   LQ +   
Sbjct: 1141 QRSDLSRELEEISERL-----EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195

Query: 762  FELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSC 821
              L K    ++A+    ++  ++ + K++K+  +       K  I  LA+N         
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE------MKMEIDDLASN--------- 1240

Query: 822  ASLFTWMESFKEGIGML--VCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISS 879
                  +E+  +  G L  +C        +    ++EQ R +        +DL A     
Sbjct: 1241 ------VETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI--------NDLTAQRGRL 1286

Query: 880  MAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVME---------CIPLHSSRS 930
              E  +   + D    +   L  G  K +F + ++++   +E            L SSR 
Sbjct: 1287 QTESGEFSRQLDEKEALVSQLSRG--KQAFTQQIEELKRQLEEEIKAKNALAHALQSSRH 1344

Query: 931  IT------YVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLH 984
                    Y E+      L   L K NT   ++  +      + T  L++      QRL 
Sbjct: 1345 DCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1404

Query: 985  AAEVERRSLRLEVTEFKRSVNEMKKELD------------------KAQGLQMQLNEFKQ 1026
            AAE    ++  +    +++   ++ E++                  K +     L E+KQ
Sbjct: 1405 AAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQ 1464

Query: 1027 SKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGE 1086
                TH + E++ +E  +      + +    E   QL+ L  + +    E +D  + + E
Sbjct: 1465 KCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAE 1524

Query: 1087 AVKSLSEAKMELRRKDQSLRQLNRHLTQLEQD---------KRRLEENIHDAESALRMAA 1137
              K + E +   ++ +Q   +L   L + E           + +LE N   +E   ++A 
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1584

Query: 1138 KDKE---CVANHMRAVENTLHKVRDQISLSWSAASRND 1172
            KD+E      NH+R VE+       Q +L     SRND
Sbjct: 1585 KDEEIDQLKRNHIRIVESM------QSTLDAEIRSRND 1616



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 58/268 (21%), Positives = 114/268 (42%), Gaps = 16/268 (5%)

Query: 987  EVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNAL 1046
            E ++   +L+  EF+ S  + K E ++A G+Q+Q    +    I   + E   E  + A 
Sbjct: 1078 EKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAK 1137

Query: 1047 LREEQAQML--LNEQAQQLQEL----NYKLELHSSEEAD---KNQTLGEAVKSLSEAKME 1097
              ++++ +   L E +++L+E     + ++E++   EA+     + L EA          
Sbjct: 1138 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1197

Query: 1098 LRRKD-QSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHK 1156
            LR+K   S+ +L   +  L++ K++LE+   + +  +   A + E V+     +E     
Sbjct: 1198 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRT 1257

Query: 1157 VRDQISLSWSAASR-----NDFTLQLPKLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQ 1211
            + DQ+S   S         ND T Q  +L  E+          E +  Q          Q
Sbjct: 1258 LEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQ 1317

Query: 1212 LASTRIMTLEKEMTSHRSHIAALKSELH 1239
            +   +   LE+E+ +  +   AL+S  H
Sbjct: 1318 IEELK-RQLEEEIKAKNALAHALQSSRH 1344



 Score = 34.7 bits (78), Expect = 0.62
 Identities = 58/311 (18%), Positives = 119/311 (38%), Gaps = 62/311 (19%)

Query: 967  KSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELD-KAQGLQMQLNEFK 1025
            K  A+++++       L  +E +R+ L  ++    +  N+++ ++  +A+GL        
Sbjct: 853  KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA------- 905

Query: 1026 QSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKL--------------- 1070
                      E  C++L    ++ E     + E+A+  +E+N +L               
Sbjct: 906  --------DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 957

Query: 1071 ---------------ELHSSEEADKNQT-----LGEAVKSLSEAKMELRRKDQ----SLR 1106
                           E H++E   KN T     L E +  L++ K  L+   Q     L+
Sbjct: 958  KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1017

Query: 1107 QLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWS 1166
                 +  L + K +LE+ + D E +L    K +  +    R +E  L   ++ I    +
Sbjct: 1018 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN 1077

Query: 1167 AASRNDFTLQLPKLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQLASTRIMTLEKEMTS 1226
               + D      KL  + F +  L+   ++   QA+        +    RI  LE+E+ +
Sbjct: 1078 EKQQLD-----EKLKKKEFEISNLQS--KIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130

Query: 1227 HRSHIAALKSE 1237
             R+  A  + +
Sbjct: 1131 ERASRAKAEKQ 1141


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  114 bits (284), Expect = 8e-25
 Identities = 225/1157 (19%), Positives = 469/1157 (40%), Gaps = 168/1157 (14%)

Query: 23   KQILKNETELDITDNLRKKL---HWA------KKEKLEITTKHNAELASYESQIAKLRSE 73
            K + + E+   I  N+R  +   HW       K + L  + +   E+A+ + +  K + E
Sbjct: 807  KMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEE 866

Query: 74   VEKGEALRQSLEYDLAVARKEAG---LGRRAAEERLAEAHRIQEKLCAQNSELQAKTNE- 129
            + K EA R+ LE  +    +E     L  +A  + LA+A    ++L     +L+AK  E 
Sbjct: 867  LAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEV 926

Query: 130  TEKA---------FQTSQQKWKEECRRFEHDLEE--------------RDNMIQNCNREY 166
            TE+A             ++K ++EC   + D+++               +N ++N   E 
Sbjct: 927  TERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM 986

Query: 167  D-------LLMKEKSRLEKTLQEALEKHQREKNEMESHIR------------ETALEEFR 207
                     L KEK  L++  Q+ L+  Q E++++ +  +            E +LE+ +
Sbjct: 987  AGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEK 1046

Query: 208  LQEEQWEAERRELQF---IVQEQDTAVQNMHKKV-EKLETEHMDCSDLLRRQTSELEFST 263
                  E  +R+L+    + QE    ++N  +++ EKL+ +  + S L  +   E     
Sbjct: 1047 KIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGM 1106

Query: 264  QREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNS-------EIIQLRIRDLEGALQ 316
            Q ++++ KE +A   R+ +LEE IEAERA+  +++          E I  R+ +  GA  
Sbjct: 1107 QLQKKI-KELQA---RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1162

Query: 317  VEKASQAEAVADLEIIKNEFKEVESAYE------REKHNAQESFAKLNLLEKEYFSKNKK 370
             +     +  A+ + ++ + +E    +E      R+KH   +S A+L           +K
Sbjct: 1163 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH--ADSVAELGEQIDNLQRVKQK 1220

Query: 371  LNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDS 430
            L ++  E K  I DL+  ++   K+   L E++  A + Q   ++T E   + L + L +
Sbjct: 1221 LEKEKSEMKMEIDDLASNMETVSKAKGNL-EKMCRALEDQLSEIKTKEEEQQRLINDLTA 1279

Query: 431  FTVSGQWTSGIH-KDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEE-----KACNELDS 484
                 Q  SG + +  D+  +    L R ++  T    +L+    EE        + L S
Sbjct: 1280 QRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQS 1339

Query: 485  TKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQ 544
            ++   D   +  +E Q+  A++ + +S  +++ A       T  ++    L   +K+ AQ
Sbjct: 1340 SRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1399

Query: 545  AAQSESE-----------LQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDK 593
              Q   E           L+K  Q    + E+ +  +    +   A C  + + +   DK
Sbjct: 1400 RLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDV----ERTNAACAALDKKQRNFDK 1455

Query: 594  F--SWSELCAVLQENVDA-----------LIADLNRANEKIRHLEYICKNKSDTMRELQQ 640
                W + C      ++A           L    N   E +  LE + +   +  +E+  
Sbjct: 1456 ILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1515

Query: 641  TQEDT---------FTKVAEQIKAQESCWHRQKKELE--LQYSE-----LFLEV-QKRAQ 683
              E             K+ +Q++ ++S      +E E  L++ E     + LE+ Q +++
Sbjct: 1516 LTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1575

Query: 684  KFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYS 743
              ++IAEK+ E+++ ++++H ++V      +  L    R +   +     M G L  +  
Sbjct: 1576 VDRKIAEKD-EEIDQMKRNHIRIV---ESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEI 1631

Query: 744  R-SCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFR 802
            + + A     + L+   NT  + K     L  AL + E+ K++ A ++++    L++   
Sbjct: 1632 QLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRA--NLLQAEI 1689

Query: 803  KGVIAVL----------------AANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQD 846
            + + A L                A+ R+++L     SL    +  +  I  +   GE +D
Sbjct: 1690 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQI--QGEMED 1747

Query: 847  KHKFPKHQKEQLR------CLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHL 900
              +  ++ +E+ +       + A       D  A +      L+  +            L
Sbjct: 1748 IIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807

Query: 901  LIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLR 960
             +   K    KL  ++  +   +     R++  V+     +R    L    T   +   +
Sbjct: 1808 ALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKEL----TYQTEEDRK 1863

Query: 961  GHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQ 1020
              + +      LQ ++  + ++  A E E +S  + +++F+R  +E+++  ++A   + Q
Sbjct: 1864 NILRLQDLVDKLQAKVKSYKRQ--AEEAEEQS-NVNLSKFRRIQHELEEAEERADIAESQ 1920

Query: 1021 LNEFKQSKLITHEKFES 1037
            +N+ +      H K  S
Sbjct: 1921 VNKLRVKSREVHTKIIS 1937



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 218/1080 (20%), Positives = 440/1080 (40%), Gaps = 151/1080 (13%)

Query: 126  KTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQ---- 181
            K+ ETEK         KEE  + + +L + +   +    +   LM+EK+ L+  +Q    
Sbjct: 845  KSAETEK----EMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEAD 900

Query: 182  ------EALEKHQREKNEMESHIRETALEEFRLQEE---QWEAERRELQFIVQEQDTAVQ 232
                  E  ++  + K ++E+ I+E   E    +EE   +  A++R+L+    E    + 
Sbjct: 901  SLADAEERCDQLIKTKIQLEAKIKEVT-ERAEDEEEINAELTAKKRKLEDECSELKKDID 959

Query: 233  NMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERA 292
            ++   + K+E E     + ++  T E+    +   +L KE +A     ++  ++++AE  
Sbjct: 960  DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE-- 1017

Query: 293  AHLESKFNSEI-----IQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREK 347
               E K N+       ++ ++ DLEG+L+ EK  + +       ++ + K  + +    +
Sbjct: 1018 ---EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIE 1074

Query: 348  HNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAK 407
            ++ Q+   KL   E E      K    IE+++ + + L K+++  +    EL+EE+   +
Sbjct: 1075 NDKQQLDEKLKKKEFEMSGLQSK----IEDEQALGMQLQKKIKELQARIEELEEEIEAER 1130

Query: 408  KHQAFLVETCENNVKELESILDSFTVSGQWTSG-IHKDKDKPPSFSVVLERLRRTLTD-- 464
              +A   +   +  +ELE I +    +G  TS  I  +K +   F    +++RR L +  
Sbjct: 1131 ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEF----QKMRRDLEEAT 1186

Query: 465  YQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALI 524
             Q++   A+  +K  + +    ++ID+  +  ++L+ + +++  E+  L    A     +
Sbjct: 1187 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL----ASNMETV 1242

Query: 525  STLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLI 584
            S  K  L+ +    E + ++    E E Q+L            T      + L     L+
Sbjct: 1243 SKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLV 1302

Query: 585  KQPEGMLDKFSWS--ELCAVLQENVDALIADLNRANEKIRH----LEYICKNKSDTMREL 638
             Q       F+    EL   L+E + A  A L  A +  RH    L    + + +   EL
Sbjct: 1303 SQLSRGKQAFTQQIEELKRQLEEEIKAKSA-LAHALQSSRHDCDLLREQYEEEQEAKAEL 1361

Query: 639  QQTQEDTFTKVAEQIKAQESCWHRQKKELE---------LQYSELFLE--------VQKR 681
            Q+      ++VA+     E+   ++ +ELE         LQ +E  +E        ++K 
Sbjct: 1362 QRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKT 1421

Query: 682  AQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPL 741
             Q+ Q   E  M  +     +   L  +  +F K+L++ +++       C      L   
Sbjct: 1422 KQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQK-------CEETHAELEAS 1474

Query: 742  YSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIF 801
               S +LST            ELFK++     ++L  +E  K+E   ++++    L    
Sbjct: 1475 QKESRSLST------------ELFKIK-NAYEESLDQLETLKRENKNLQQE-ISDLTEQI 1520

Query: 802  RKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCL 861
             +G   +    ++K            +E  K  +   +   E   +H+  K  + QL   
Sbjct: 1521 AEGGKRIHELEKIK----------KQVEQEKSELQAALEEAEASLEHEEGKILRIQLELN 1570

Query: 862  QALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSF--AKLMDKISLV 919
            Q  S          +   +AE  + I +   N     H+ I  +  S   A++  +   +
Sbjct: 1571 QVKS---------EVDRKIAEKDEEIDQMKRN-----HIRIVESMQSTLDAEIRSRNDAI 1616

Query: 920  MECIPLHSSRSITYVEKDSLVQRLAHGLHKV-NTLALKYGLRGHVP-ITKSTASLQKQIL 977
                 +    +   ++ +   +  A  L    NT A+    + H+    +S   L++Q+ 
Sbjct: 1617 RLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLA 1676

Query: 978  GFTQR--LHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKF 1035
               +R  L  AE+E     LE TE  R + E +  LD ++ +Q+ L+    S + T +K 
Sbjct: 1677 MVERRANLLQAEIEELRATLEQTERSRKIAEQEL-LDASERVQL-LHTQNTSLINTKKKL 1734

Query: 1036 ESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAK 1095
            E+   ++   +  E+  Q                 E  ++EE        +A K++++A 
Sbjct: 1735 ETDISQIQGEM--EDIIQ-----------------EARNAEE--------KAKKAITDAA 1767

Query: 1096 M---ELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAES-ALRMAAKDKECVANHMRAVE 1151
            M   EL+++  +   L R    LEQ  + L+  + +AE  AL+   K  + +   +R +E
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELE 1827



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 100/434 (23%), Positives = 185/434 (42%), Gaps = 70/434 (16%)

Query: 19   SLDVKQILKNETE------LDITDNLR---KKLHWAKKEKLEITTKHNAELASYESQIAK 69
            SLD  + LK E +       D+T+ +    K++H  +K K ++  + +   A+ E   A 
Sbjct: 1495 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEAS 1554

Query: 70   LRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAE-ERLAEAH-RIQEKLCAQNSELQAKT 127
            L  E E+G+ LR  LE +   +  +  +  +  E +++   H RI E +    S L A+ 
Sbjct: 1555 L--EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESM---QSTLDAEI 1609

Query: 128  NETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREY----------DLLMKEKSRLE 177
                 A +  ++K + +    E  L   + M     R Y           L + +  R +
Sbjct: 1610 RSRNDAIRL-KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQ 1668

Query: 178  KTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERR----------ELQFIVQEQ 227
            + L+E L   +R  N +++ I     EE R   EQ E  R+          E   ++  Q
Sbjct: 1669 EDLKEQLAMVERRANLLQAEI-----EELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1723

Query: 228  DTAVQNMHKKVE--------KLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLR 279
            +T++ N  KK+E        ++E    +  +   +    +  +    E L+KE + T+  
Sbjct: 1724 NTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKE-QDTSAH 1782

Query: 280  VRKLEENIE------------AERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVA 327
            + ++++N+E            AE+ A    K   + ++ R+R+LEG ++ E+    EAV 
Sbjct: 1783 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVK 1842

Query: 328  DLEIIKNEFKEVESAYEREKHN---AQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIID 384
             L   + + KE+    E ++ N    Q+   KL    K Y    K+  E+ EEQ  V + 
Sbjct: 1843 GLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSY----KRQAEEAEEQSNVNLS 1898

Query: 385  LSKRLQYNEKSCSE 398
              +R+Q+  +   E
Sbjct: 1899 KFRRIQHELEEAEE 1912



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 148/773 (19%), Positives = 283/773 (36%), Gaps = 120/773 (15%)

Query: 466  QNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELS----HLHTKCADRE 521
            Q + +  ++ E+ C++L  TK ++++  K + E  +   ++N EL+     L  +C++ +
Sbjct: 896  QAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 955

Query: 522  ALISTLKVELQNVLHCWEKEKAQAAQS----ESELQKLSQAFHKDAEEKLTFLHTLYQHL 577
              I  L++ L  V    EKEK            E+  L +   K  +EK        Q L
Sbjct: 956  KDIDDLELTLAKV----EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTL 1011

Query: 578  VAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIA----------DLNRANEKIR-HLEY 626
                  ++  E  ++  + +++   L++ VD L            DL RA  K+   L+ 
Sbjct: 1012 DD----LQAEEDKVNTLTKAKI--KLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKL 1065

Query: 627  ICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQ 686
              ++  D   + QQ  E    K  E    Q      Q   ++LQ  +   E+Q R ++ +
Sbjct: 1066 AQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQ--KKIKELQARIEELE 1123

Query: 687  EIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSC 746
            E  E         EK    L  E     + L     E+     +  +          +  
Sbjct: 1124 EEIEAERASRAKAEKQRSDLSRELEEISERL-----EEAGGATSAQIEMNKKREAEFQKM 1178

Query: 747  ALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVI 806
                +   LQ +     L K    ++A+    ++  ++ + K++K+  +       K  I
Sbjct: 1179 RRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE------MKMEI 1232

Query: 807  AVLAANRLKILGQSCASLFTWMESFKEGIGML--VCTGEPQDKHKFPKHQKEQLRCLQAL 864
              LA+N               ME+  +  G L  +C        +    ++EQ R +   
Sbjct: 1233 DDLASN---------------METVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLI--- 1274

Query: 865  SWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVME--- 921
                 +DL A       E  +   + D    +   L  G  K +F + ++++   +E   
Sbjct: 1275 -----NDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRG--KQAFTQQIEELKRQLEEEI 1327

Query: 922  ------CIPLHSSRSIT------YVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKST 969
                     L SSR         Y E+      L   + K N+   ++  +      + T
Sbjct: 1328 KAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRT 1387

Query: 970  ASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELD----------------- 1012
              L++      QRL  AE    ++  +    +++   ++ E++                 
Sbjct: 1388 EELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALD 1447

Query: 1013 -KAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLE 1071
             K +     L E+KQ    TH + E++ +E  +      + +    E   QL+ L  + +
Sbjct: 1448 KKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENK 1507

Query: 1072 LHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQD---------KRRL 1122
                E +D  + + E  K + E +   ++ +Q   +L   L + E           + +L
Sbjct: 1508 NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQL 1567

Query: 1123 EENIHDAESALRMAAKDKE---CVANHMRAVENTLHKVRDQISLSWSAASRND 1172
            E N   +E   ++A KD+E      NH+R VE+       Q +L     SRND
Sbjct: 1568 ELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESM------QSTLDAEIRSRND 1614



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 46/206 (22%), Positives = 93/206 (45%), Gaps = 15/206 (7%)

Query: 994  RLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQ 1053
            +L+  EF+ S  + K E ++A G+Q+Q    +    I   + E   E  + A   ++++ 
Sbjct: 1083 KLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1142

Query: 1054 ML--LNEQAQQLQEL----NYKLELHSSEEAD---KNQTLGEAVKSLSEAKMELRRKD-Q 1103
            +   L E +++L+E     + ++E++   EA+     + L EA          LR+K   
Sbjct: 1143 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1202

Query: 1104 SLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISL 1163
            S+ +L   +  L++ K++LE+   + +  +   A + E V+     +E     + DQ+S 
Sbjct: 1203 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSE 1262

Query: 1164 SWSAASR-----NDFTLQLPKLHLET 1184
              +         ND T Q  +L  E+
Sbjct: 1263 IKTKEEEQQRLINDLTAQRARLQTES 1288



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 68/315 (21%), Positives = 122/315 (38%), Gaps = 58/315 (18%)

Query: 964  PITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKE--LDKAQGLQMQL 1021
            P+ KS A  +K++    +     E E+    L  TE KR   E K    + +   LQ+Q+
Sbjct: 842  PLLKS-AETEKEMANMKE-----EFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQV 895

Query: 1022 NEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKL----------- 1070
                Q++  +    E  C++L    ++ E     + E+A+  +E+N +L           
Sbjct: 896  ----QAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 951

Query: 1071 -------------------ELHSSEEADKNQT-----LGEAVKSLSEAKMELRRKDQ--- 1103
                               E H++E   KN T     L E +  L++ K  L+   Q   
Sbjct: 952  SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTL 1011

Query: 1104 -SLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQIS 1162
              L+     +  L + K +LE+ + D E +L    K +  +    R +E  L   ++   
Sbjct: 1012 DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQES-- 1069

Query: 1163 LSWSAASRNDFTLQLPKLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQLASTRIMTLEK 1222
               +    ND      KL  + F M GL+   ++   QA+        +    RI  LE+
Sbjct: 1070 ---TMDIENDKQQLDEKLKKKEFEMSGLQS--KIEDEQALGMQLQKKIKELQARIEELEE 1124

Query: 1223 EMTSHRSHIAALKSE 1237
            E+ + R+  A  + +
Sbjct: 1125 EIEAERASRAKAEKQ 1139


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  113 bits (283), Expect = 1e-24
 Identities = 278/1322 (21%), Positives = 540/1322 (40%), Gaps = 232/1322 (17%)

Query: 3    LNTSSNTGDTQRLKIASLD--VKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAEL 60
            L+T+  T + +R   A +D  +K I K   E  I+  L+++L   K+E +++  K     
Sbjct: 420  LSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERIS--LQQELSRVKQEVVDVMKK----- 472

Query: 61   ASYESQIAKLRSEVEKGEALR-QSLEYDLAVARKEAGLGRRAAEER-------LAEAHRI 112
             S E QIAKL+   EK  A + Q L   L    +E     + A E+       +++    
Sbjct: 473  -SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQ 531

Query: 113  QEKLCAQNSELQAKTNETE-----KAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYD 167
            QE L  +  ELQ K   TE     +  Q   + ++      E  LE+  ++ +N N+  D
Sbjct: 532  QESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEK--SLQENKNQSKD 589

Query: 168  L---LMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERREL-QFI 223
            L   L  EK++  K +   +EKH+ E   ++        E+ ++ ++Q++ E  +L +  
Sbjct: 590  LAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKC 649

Query: 224  VQEQDTAVQNMH------------KKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRK 271
             QE++T +++              K +EKL+ +  +   L    +SEL    +   +L +
Sbjct: 650  EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESL----SSELSEVLKARHKLEE 705

Query: 272  EFEATTLRVRKLEENIEA---ERAAHLESKFNSEI--------------------IQLRI 308
            E      +  K+++ +EA   E+  H + + +S I                    ++L +
Sbjct: 706  ELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLL 765

Query: 309  RDLEGALQVEKASQAEAVADLEIIKNE----------FKEVESAYEREKHNAQESFAKLN 358
            ++ +  L+  +A      AD++  + E          F+  +SA   +    +E  A+L 
Sbjct: 766  KERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQ 825

Query: 359  L----LEKEYFSKNKKLNEDIEEQKKVI--------IDLSKRLQYNEKSCSELQEEL--- 403
                 LE E     K++ E +E QKK +        I +   +Q  EK  SE+++++   
Sbjct: 826  QKLLDLETERILLTKQVAE-VEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL 884

Query: 404  --------------------VMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIH- 442
                                ++ +K    L +  E   KE+E +    +        IH 
Sbjct: 885  TQVYESKLEDGNKEQEQTKQILVEKENMIL-QMREGQKKEIEILTQKLSAK---EDSIHI 940

Query: 443  -------KDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTK- 494
                   K K++      V ++ +      + KL D   E K   EL++T  ++    K 
Sbjct: 941  LNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLD--QEAKLKKELENTALELSQKEKQ 998

Query: 495  -NIKEL---QDKLADVNKELSHLHTKCADR-EALISTLKVELQNVLHCWEKEKAQAAQSE 549
             N K L   Q   A ++  +S L T   ++ E+L    + EL +V+  WEK+  Q A+  
Sbjct: 999  FNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAE-- 1056

Query: 550  SELQKLSQAFHKDAEEKLTFLHTLYQHLVAGC--------VLIKQPEGMLDKFSWSELCA 601
             ELQ++ +   ++ E+++  L    + L+ GC        +   + EG+    + +EL  
Sbjct: 1057 -ELQEIHEIQLQEKEQEVAELKQ--KILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQE 1113

Query: 602  VLQE---NVDALIADLNRANEKIRHLEYICKNKS--------DTMRELQQTQEDTFTKVA 650
             L++   +V++L  D  +    +  LE +  NKS        + + EL+   E+   KV+
Sbjct: 1114 QLKQKSAHVNSLAQDETKLKAHLEKLE-VDLNKSLKENTFLQEQLVELKMLAEEDKRKVS 1172

Query: 651  E----------QIKAQESCWHRQKKELE---LQYS----ELFLEVQKRAQKFQEIAEKNM 693
            E          + ++ +S   +  K LE   L++     EL +++    +K + + E   
Sbjct: 1173 ELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKT 1232

Query: 694  EKLNHIEKSHEQLVLEN-SHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQ- 751
             +L +I  S    +L   SH +   ++ +   +      + +   L  L      L+   
Sbjct: 1233 NELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISF 1292

Query: 752  ---RDFLQEQVNTFELFKLEIRTLA---QALSTVEEKKQEEAKMKKKTFKGLIRIFRKGV 805
                  L+E+ N  +  K +I +L    +AL      +Q+ A  K+     L +   + +
Sbjct: 1293 QQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENI 1352

Query: 806  IAV-LAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRC---- 860
             AV L    LK      +SL   +      +   +   E +      + Q ++ +C    
Sbjct: 1353 NAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLD 1412

Query: 861  -LQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLV 919
             +Q LS+   + L    IS++ ++ D   K     +         A++ F +  + +  +
Sbjct: 1413 QVQDLSFKVDT-LSKEKISALEQVDDWSNKFSEWKK--------KAQSRFTQHQNTVKEL 1463

Query: 920  MECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTL--ALKYGLRGHVP-ITKSTASLQKQI 976
               + L S  +    EKD  +  L   L + N     LK  +      + K  ++L+ ++
Sbjct: 1464 QIQLELKSKEAY---EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1520

Query: 977  LGFTQRLHAAE--VERRSLRLE-VTEFKRSVNEMK----KEL-DKAQGLQMQLNEFK--- 1025
               T R+   E  + ++++ +E + E  ++ N+ K    KEL  K Q  Q +L E K   
Sbjct: 1521 KSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQ-ELGEEKDNR 1579

Query: 1026 ----QSKLITHE-KFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADK 1080
                + K++T E +  S   EL       E   + +  + ++L+ L  +LE  S+ +  +
Sbjct: 1580 VKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAE 1639

Query: 1081 NQTLGE----AVKSLSEAKMELRRK------DQSLRQLNRHLTQLEQDKRRLEENIHDAE 1130
             +   E    A+K    ++ME + +      +  L +LN  L + E++   LEE +   E
Sbjct: 1640 LKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVE 1699

Query: 1131 SA 1132
            S+
Sbjct: 1700 SS 1701



 Score = 84.0 bits (206), Expect = 9e-16
 Identities = 249/1244 (20%), Positives = 491/1244 (39%), Gaps = 191/1244 (15%)

Query: 57   NAELASYESQIAKLRSEVEKGEAL-RQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQ-E 114
            N E    +S   KL+  V   E+L R  ++  L  +  +  L R ++ E L   +R+  +
Sbjct: 52   NRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESL---NRLDLD 108

Query: 115  KLCAQNSELQAKTNETEKAFQTSQQKWKEEC----RRFEHDLEERDNMIQNCNREYDLLM 170
               A         +E E     S    KE+     RR E  L             Y +L 
Sbjct: 109  SSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQ 168

Query: 171  KEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTA 230
            +EK +L+  L ++ +K  R   E+         EE ++ ++  +  + E    ++E+D  
Sbjct: 169  REKKKLQGILSQSQDKSLRRIAELR--------EELQMDQQAKKHLQEEFDASLEEKDQY 220

Query: 231  VQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAE 290
            +  +  +V  L+                        +RLR       + V  L+   + E
Sbjct: 221  ISVLQTQVSLLK------------------------QRLRNG----PMNVDVLKPLPQLE 252

Query: 291  RAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNA 350
              A + +K  +        + +G   VE  +   +V  LE ++   K  E+  +R K   
Sbjct: 253  PQAEVFTKEENP-------ESDGEPVVEDGT---SVKTLETLQQRVKRQENLLKRCKETI 302

Query: 351  QESFAKLNLLEKEYFSKNKKLNEDIEEQKKVI-------IDLSKRLQYNEKSCSELQEEL 403
            Q    +  LL  E  +  ++L+E ++E +K+          L  +L+  +    +L+++ 
Sbjct: 303  QSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDK 362

Query: 404  VMA----KKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLR 459
             M     K+     +E  E  + +L S +   T  G+    + + K+K  S     E L 
Sbjct: 363  GMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGE---ELREQKEK--SERAAFEELE 417

Query: 460  RTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIK-ELQDKLADVNKELSHLHTKCA 518
            + L+  Q K E+A  + KA  E+D   + I+  ++  +  LQ +L+ V +E+  +  K +
Sbjct: 418  KALSTAQ-KTEEARRKLKA--EMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS 474

Query: 519  DREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLV 578
            + +        +LQ  LH  EKE    A+ E EL K  Q   ++ +E++           
Sbjct: 475  EEQI------AKLQK-LH--EKE---LARKEQELTKKLQTREREFQEQMKVA-------- 514

Query: 579  AGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMREL 638
                        L+K S SE   + QE        L     + + +    +NK   +R+L
Sbjct: 515  ------------LEK-SQSEYLKISQEKEQQESLALEELELQKKAILTESENK---LRDL 558

Query: 639  QQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNH 698
            QQ  E   T++ E   + E      K + +     L  E  K  ++   + EK+  +L  
Sbjct: 559  QQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELES 618

Query: 699  IEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQ 758
            ++  H+Q  L     + L  Q Q E   L   C      L  L  +        + + E+
Sbjct: 619  LK--HQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETL--LKDKEIIFQAHIEEMNEK 674

Query: 759  -VNTFELFKLEIRTLAQALSTV----EEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANR 813
             +   ++ + E+ +L+  LS V     + ++E + +K +T K      ++ + A +   +
Sbjct: 675  TLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDK-----MKQELEAKMDEQK 729

Query: 814  L-------KILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSW 866
                     I+ +   S+    ++ K+ I  L    + +DKH   +HQ            
Sbjct: 730  NHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKH-LKEHQAH---------- 778

Query: 867  LTSSDLLAAIISSMAELQDVIGKAD--PNSRICGHLLIGAAKNSFAKLMDKISLVMECIP 924
                +L A I  S  ELQ    K D   + +   H    A +   A+L  K+ L +E   
Sbjct: 779  --VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL-LDLETER 835

Query: 925  LHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQ--- 981
            +  ++ +  VE            HK+    L   L       K  + +++++   TQ   
Sbjct: 836  ILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLE------KQNSEMEQKVKSLTQVYE 889

Query: 982  -RLHAAEVERRSLRLEVTEFKRSVNEMKK-ELDKAQGLQMQLNEFKQSKLITHEKFESAC 1039
             +L     E+   +  + E +  + +M++ +  + + L  +L+  + S  I +E++E+  
Sbjct: 890  SKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKF 949

Query: 1040 EELNNAL---------LREEQAQMLLNEQAQQLQEL-NYKLELHSSEEADKNQTLGEAVK 1089
            +     +         ++E   + LL+++A+  +EL N  LEL   E+    + L  A  
Sbjct: 950  KNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQA 1009

Query: 1090 SLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKD-KECVANHMR 1148
            + +     + R + + ++    LT++   +R L + I   E  L   A++ +E     ++
Sbjct: 1010 NSAGISDAVSRLETNQKEQIESLTEVH--RRELNDVISIWEKKLNQQAEELQEIHEIQLQ 1067

Query: 1149 AVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLET--FAMEGLKGGPEVVACQAMIKSF 1206
              E  + +++ +I L         F  +  +++ E      EG+K    +   Q  +K  
Sbjct: 1068 EKEQEVAELKQKILL---------FGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQ- 1117

Query: 1207 MDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTACLRENASLQ 1250
                   S  + +L ++ T  ++H+  L+ +L+ + L+EN  LQ
Sbjct: 1118 ------KSAHVNSLAQDETKLKAHLEKLEVDLNKS-LKENTFLQ 1154



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 154/819 (18%), Positives = 321/819 (39%), Gaps = 93/819 (11%)

Query: 50   LEITTKHNAELASYESQIAKLRSEV--EKGEALRQ--SLEYDLAVARKEAGLGRRAAEER 105
            L +  +++  L+  E+ I+ LR +   EK E L Q   L + +    KE        ++ 
Sbjct: 1379 LNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDW 1438

Query: 106  LAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNRE 165
              +    ++K  ++ ++ Q    E +   +   ++  E+  +     EE D      N+ 
Sbjct: 1439 SNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ----NKR 1494

Query: 166  YDLLMKE----KSRLEK---TLQEALEKHQREKNEMESHIRETALEEFRLQE------EQ 212
            +D L  E    KS++EK    L+  L+       E+E HI +  +E   L E      +Q
Sbjct: 1495 FDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQ 1554

Query: 213  WEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKE 272
             + E +EL   +Q      +    +V++ E + +   + +    +ELE   +  E +   
Sbjct: 1555 KDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLS 1614

Query: 273  FEATTLRVRKLEENIEAERAAHL-------ESKFNSEIIQLRIRDLEGALQVEKASQA-- 323
             ++    ++ LE+ +E+E AA L       E K  +   QL  +  E   Q +K +++  
Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHL 1674

Query: 324  --------EAVADLEIIKNEFKEVESAYER-----------EKHNAQESFAKLNLLEKEY 364
                    E   ++ I++ + K VES+                +  QE       ++K Y
Sbjct: 1675 SELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTY 1734

Query: 365  FSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQ---EELVMAKKHQAFLVETCENNV 421
              K   L  ++ E++K++  + +  +    S  E++   +E ++  +H        ++ +
Sbjct: 1735 EEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMI 1794

Query: 422  KELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNE 481
              L+  L+            H +K+   +     + L     D Q  L++   +E  C  
Sbjct: 1795 GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQE---KELTCQI 1851

Query: 482  LDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALIS-TLKVELQNVLHCWEK 540
            L+   +++DS     KE+         E+  L +K    +AL     + +   +L    +
Sbjct: 1852 LEQKIKELDSCLVRQKEVH------RVEMEELTSKYEKLQALQQMDGRNKPTELLEENTE 1905

Query: 541  EKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELC 600
            EK+++   + +L    +A H D E KL       Q L    V +++   ML K    EL 
Sbjct: 1906 EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQEL- 1964

Query: 601  AVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCW 660
             +L++  D          EKI+              +L+     T  ++  +   Q +  
Sbjct: 1965 EILKKEYD------QEREEKIK----------QEQEDLELKHNSTLKQLMREFNTQLA-- 2006

Query: 661  HRQKKELELQYSELFLEVQK-RAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQ 719
             ++++ELE+   E   + Q+  A+  +   E+  + L  I +  + L      ++++L  
Sbjct: 2007 -QKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDA 2065

Query: 720  TQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRT-LAQALST 778
             + E  + +         L   Y        Q+   +E      +  +E++T LAQ  + 
Sbjct: 2066 REEEMTAKVRDLQTQLEELQKKYQ-------QKLEQEENPGNDNVTIMELQTQLAQKTTL 2118

Query: 779  VEEKKQEEAKMKKK--TFKGLIRIFRKGVIAVLAANRLK 815
            + + K +E + +++    +  ++ + K V A       K
Sbjct: 2119 ISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYK 2157


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  112 bits (281), Expect = 2e-24
 Identities = 246/1299 (18%), Positives = 516/1299 (39%), Gaps = 128/1299 (9%)

Query: 37   NLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAG 96
            NL+K+L  A   +LE++ +   +  S E  + KL+ E+EK   +R   E  +   +K+  
Sbjct: 151  NLQKQLEEAMNTQLELSEQLKFQNNS-EDNVKKLQEEIEK---IRPGFEEQILYLQKQLD 206

Query: 97   LGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAF----QTSQQKWKEECRRFEHDL 152
                  +E + +   I E   A +   Q   N  ++         Q++ KE   + E   
Sbjct: 207  ATTDEKKETVTQLQNIIE---ANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASA 263

Query: 153  EERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQ 212
            +E +  I   N   + L+K+         EA EK+ ++K E E      A        + 
Sbjct: 264  KEHEAEINKLNELKENLVKQC--------EASEKNIQKKYECELENLRKATSNANQDNQI 315

Query: 213  WEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTS---ELEFSTQR---- 265
                 +E  F+ Q  +  V+++   +++LE++H    D +    +   +LE   Q     
Sbjct: 316  CSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDE 375

Query: 266  --EERLRKEFEATTLRVRKLEENIEAERA----AHLESKF-------NSEIIQLRIRDLE 312
               ER   EF+   L + K E+    E+     A L  +F       N E+  L+ +  +
Sbjct: 376  FFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQK 435

Query: 313  GALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAK-------LNLLEKEYF 365
               ++ +   +++  +   +  E + ++   E  +   QE+          + +L+ E  
Sbjct: 436  EISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELG 495

Query: 366  SKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELE 425
                K++++ E  K          Q       ELQ++L  A   +  L+ET      E E
Sbjct: 496  ESAGKISQEFESMK----------QQQASDVHELQQKLRTAFTEKDALLETVNRLQGENE 545

Query: 426  SILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNE-EKACNELDS 484
             +L    +  +  + I   ++K   + + L +    L + + K+   + E +   N+L +
Sbjct: 546  KLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKN 605

Query: 485  TKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQ 544
            + +++D+  K  +  +  + ++ K++       ++ E  ++ L   L+  L    KEK Q
Sbjct: 606  SHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETL----KEKDQ 661

Query: 545  AAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQ 604
              Q   +L    +   +D E     + +LY+         KQ    L+ F   +   +L+
Sbjct: 662  NDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILK 721

Query: 605  ENVDALIADLNRANEKIRHLEYICKNKS-----------DTMREL-----QQTQEDTFTK 648
            E++  L   L    E+  +L  + +N+              ++E+     + ++E     
Sbjct: 722  EHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVN 781

Query: 649  VAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVL 708
            V + +    +  + +K  L  Q  E  LE++K  +  QE +    E+L  + + +EQ   
Sbjct: 782  VLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQ--- 838

Query: 709  ENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLE 768
            E    +K L + Q E+ +L +    M  A     +    L  Q   +Q +  +    K E
Sbjct: 839  EKVLLRKELEEIQSEKEALQSDLLEMKNA-----NEKTRLENQNLLIQVEEVSQTCSKSE 893

Query: 769  IRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWM 828
            I    +    ++E +  +  +++K  +      R+  + +L  +  K        L + +
Sbjct: 894  IHNEKEKCF-IKEHENLKPLLEQKELRD-----RRAELILLKDSLAKSPSVKNDPLSS-V 946

Query: 829  ESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIG 888
            +  +E I  L    E + K K  K  K +L  ++A   L SS      +    EL+ +  
Sbjct: 947  KELEEKIENL----EKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKE--ELESLRS 1000

Query: 889  KADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEK-DSLVQRLAHGL 947
            + D  S     L+ GA   S+  L+ +     E + +   R+  +  + + L ++L +  
Sbjct: 1001 EKDQLSASMRDLIQGA--ESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNST 1058

Query: 948  HKVNTL-ALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNE 1006
             +  T+ +    L   +   +S A L +  +   QR  A  +  + L  E  + ++ + E
Sbjct: 1059 LQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKA--MVDKELEAEKLQKEQKIKE 1116

Query: 1007 MKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQA---QMLLNEQAQQL 1063
                +++ + LQ+QL + K+    T ++ E   ++     L   +    + L+ E  Q+L
Sbjct: 1117 HATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKL 1176

Query: 1064 QELNYKLELHSSE---EADKNQTLGEAVKSLSEAKMELRRKDQSLRQL----NRHLT--- 1113
               N K+E    E   +  K +TL E + SL  +  +   K+  ++QL     + L    
Sbjct: 1177 TNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSK 1236

Query: 1114 QLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASRNDF 1173
            Q E D   L+ ++   +  L  + +  E     +  + +  HK+ + +  S   A ++  
Sbjct: 1237 QAETDHLILQASL---KGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTS---AEQHQR 1290

Query: 1174 TLQLPKLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAA 1233
            TL   +  +     E      E    QA + S  + Y++    ++  +K  +  ++    
Sbjct: 1291 TLSAYQQRVTALQEECRAAKAE----QATVTSEFESYKVRVHNVLKQQKNKSMSQAETEG 1346

Query: 1234 LKSEL-HTACLRENASLQSIGSRDHSNLSIPSRAPLPAD 1271
             K E  H   L +   ++   S+++  +++     L ++
Sbjct: 1347 AKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSE 1385



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 236/1214 (19%), Positives = 482/1214 (39%), Gaps = 133/1214 (10%)

Query: 25   ILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEK-----GEA 79
            +L  E +  + + L+ +L    K+      +HN E+ S + Q  K  SE+ +      E 
Sbjct: 391  LLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEK 450

Query: 80   LRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQ 139
             + +L +++   +++    ++  +E +     ++E +    +EL     +  + F++ +Q
Sbjct: 451  EKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQ 510

Query: 140  KWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIR 199
            +   +     H+L+++   ++    E D L++  +RL+    E L   Q    E+E+ I+
Sbjct: 511  QQASDV----HELQQK---LRTAFTEKDALLETVNRLQGE-NEKLLSQQELVPELENTIK 562

Query: 200  ETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSEL 259
                    LQE+            + ++DT ++ +  K+  L  E  D  + L+    E+
Sbjct: 563  N-------LQEKNGV-----YLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEM 610

Query: 260  EF---STQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQ 316
            +      +REERL  E        +K+E+ I+          +NSE+ Q ++ +L G L+
Sbjct: 611  DNFHKKCEREERLILELG------KKVEQTIQ----------YNSELEQ-KVNELTGGLE 653

Query: 317  V---EKASQAEAVADLEI---IKNEFKEVESAYER---EKHNAQESFAKLNLLEKEYFSK 367
                EK    + +  L +   + +E KEV SA  +   E++N   S  K    + E F  
Sbjct: 654  ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLS 713

Query: 368  NKK---LNEDIEE-QKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKE 423
             K+   L E I + +KK+ + + ++   N+   +E  ++L +  +   FL E      ++
Sbjct: 714  QKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSED 773

Query: 424  LES--ILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNE 481
             E   +++     G+  + I+++K      ++  +R  + L   + + E    +E++  +
Sbjct: 774  SEEKDVVNVLQAVGESLAKINEEK-----CNLAFQRDEKVL---ELEKEIKCLQEESVVQ 825

Query: 482  LDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKE 541
             +  K  +  + +    L+ +L ++  E   L +   + +      ++E QN+L   E+ 
Sbjct: 826  CEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEV 885

Query: 542  KAQAAQSESELQKLSQAFHKDAEEKLTFLHTL-YQHLVAGCVLIKQPEGMLDKFSWSELC 600
                ++SE   +K  + F K+ E     L     +   A  +L+K             L 
Sbjct: 886  SQTCSKSEIHNEK-EKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLS 944

Query: 601  AV--LQENVDALIADLNRANEKIRHLEYIC---KNKSDTMRELQQTQEDTFTKVAEQIKA 655
            +V  L+E ++ L  +     EKI  ++ +    K + D+ R+  QT ++    +  + K 
Sbjct: 945  SVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSE-KD 1003

Query: 656  QESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKK 715
            Q S   R   +    Y  L LE +K++++     EK  E+ N+ E   E L  +  +   
Sbjct: 1004 QLSASMRDLIQGAESYKNLLLEYEKQSEQLD--VEK--ERANNFEHRIEDLTRQLRNSTL 1059

Query: 716  LLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFK----LEIRT 771
                   +   LLA    +      L  +   +   +  + +++   +L K     E  T
Sbjct: 1060 QCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHAT 1119

Query: 772  LAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESF 831
                L  ++ + Q+E K  +KT + L  + +        A +  ++    A     M+  
Sbjct: 1120 TVNELEELQVQLQKEKKQLQKTMQELELVKKD-------AQQTTLMNMEIADYERLMKEL 1172

Query: 832  KEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKAD 891
             + +       + +D  +  K QK++   LQ                 +  LQ  + + +
Sbjct: 1173 NQKLTNK--NNKIEDLEQEIKIQKQKQETLQ---------------EEITSLQSSVQQYE 1215

Query: 892  PNSRICGHLLIGAAKN-SFAKLMDKISLVMECI---PLHSSRSITYVEKDSLVQRLAHGL 947
              +     LL+   K  + +K  +   L+++      L +S+    V K  L + +    
Sbjct: 1216 EKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAE-ITSEK 1274

Query: 948  HKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEM 1007
            HK++   LK     H    ++ ++ Q+++    +   AA+ E+ ++  E   +K  V+ +
Sbjct: 1275 HKIHE-HLKTSAEQH---QRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNV 1330

Query: 1008 KKELDKAQGLQMQLNEFKQSKLITHEKFESACEEL--------NNALLREEQAQMLLNEQ 1059
             K+       Q +    KQ +    E  E   ++L        NN  +   + Q L +E 
Sbjct: 1331 LKQQKNKSMSQAETEGAKQER----EHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEH 1386

Query: 1060 AQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDK 1119
               L+  N  L+   S+EA+  + L          K E  +    L   N  L    +D+
Sbjct: 1387 DTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQ 1446

Query: 1120 -RRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLP 1178
             R L+E        L+      E     ++    T   V  Q SL      RN     LP
Sbjct: 1447 VRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRN---TDLP 1503

Query: 1179 KLHLETFAMEGLKG 1192
             L + T   E  +G
Sbjct: 1504 LLDMHTVTREEGEG 1517



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 211/1044 (20%), Positives = 408/1044 (39%), Gaps = 240/1044 (22%)

Query: 218  RELQFIVQEQDTAVQNMHKKVEKLETEHMD--CSDLLRRQTSELEFSTQREERLRKEFEA 275
            ++   ++Q+  +    + K++E+L ++ +     D+++  T  L+      E+   E + 
Sbjct: 35   KKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLL--EKAETEQQC 92

Query: 276  TTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNE 335
             +L+   ++   E E +       + E+ Q               S    V ++E +KNE
Sbjct: 93   LSLKKENIKMKQEVEDSVTKMGDAHKELEQ---------------SHINYVKEIENLKNE 137

Query: 336  FKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQY---N 392
               V S Y  +K N Q+                      +EE     ++LS++L++   +
Sbjct: 138  LMAVRSKYSEDKANLQKQ---------------------LEEAMNTQLELSEQLKFQNNS 176

Query: 393  EKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFS 452
            E +  +LQEE+   K    F     E  +  L+  LD+ T                    
Sbjct: 177  EDNVKKLQEEI--EKIRPGF-----EEQILYLQKQLDATT-------------------- 209

Query: 453  VVLERLRRTLTDYQNKLE-DASNEEKACNELDSTKQKIDS-HTKNIKELQDKLADVNKEL 510
               +  + T+T  QN +E ++ + +K  N L     ++ + H + +KEL          +
Sbjct: 210  ---DEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKEL----------M 256

Query: 511  SHLHTKCADREALISTLKVELQN-VLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTF 569
              +     + EA I+ L    +N V  C   EK    + E EL+ L +A     ++    
Sbjct: 257  CQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQD---- 312

Query: 570  LHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAV-LQEN--VDALIADLNRANEKIRHLEY 626
                                       +++C++ LQEN  V+ ++      NEK++HLE 
Sbjct: 313  ---------------------------NQICSILLQENTFVEQVV------NEKVKHLE- 338

Query: 627  ICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQY--SELFLEVQKRAQK 684
                  DT++EL    E   + + +++    +   + K E++ Q+   E F E +    K
Sbjct: 339  ------DTLKEL----ESQHSILKDEVTYMNNL--KLKLEMDAQHIKDEFFHEREDLEFK 386

Query: 685  FQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSR 744
              E+     E+   IEK   +L   N  F   + Q  RE  SL          L      
Sbjct: 387  INELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISEL------ 440

Query: 745  SCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKG 804
                     FL +          EI+ L +    ++++KQ EA +  ++ + ++ I +  
Sbjct: 441  ------NETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQ-EAILNYESLREIMEILQTE 493

Query: 805  VIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQAL 864
                        LG+S   +    ES K+     V   E Q K +    +K+ L  L+ +
Sbjct: 494  ------------LGESAGKISQEFESMKQQQASDV--HELQQKLRTAFTEKDAL--LETV 537

Query: 865  SWLT-SSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAK-LMDKISLVMEC 922
            + L   ++ L +    + EL++ I      + +  +LL  + +++  K L  KI+ + E 
Sbjct: 538  NRLQGENEKLLSQQELVPELENTIKNLQEKNGV--YLLSLSQRDTMLKELEGKINSLTE- 594

Query: 923  IPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQR 982
                        EKD  + +L +   +++               K     ++ IL   ++
Sbjct: 595  ------------EKDDFINKLKNSHEEMDN------------FHKKCEREERLILELGKK 630

Query: 983  LHAAEVERRSLRLEVTEFKRSVNEMKKELD----KAQGLQMQLNEFKQSKLITHEKFESA 1038
            +         L  +V E    + E  KE D    K + L +Q+    + K +   + +S 
Sbjct: 631  VEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSL 690

Query: 1039 CEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMEL 1098
             EE NN L  E+             ++L+  LE+  S++ D    L E +  L E K++L
Sbjct: 691  YEE-NNKLSSEK-------------KQLSRDLEVFLSQKED--VILKEHITQL-EKKLQL 733

Query: 1099 RRKDQSLRQLNRHLTQLEQDKRRLEENIH----DAESALRMAAKDKECVANHMRAVENTL 1154
              ++Q    LN+ L   +  K  ++  ++    +  S +   +++K+ V N ++AV  +L
Sbjct: 734  MVEEQD--NLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKD-VVNVLQAVGESL 790

Query: 1155 HKVRDQISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQLAS 1214
             K+ ++      A  R++  L+L K  ++    E       VV C+  +KS +  Y+   
Sbjct: 791  AKINEE--KCNLAFQRDEKVLELEK-EIKCLQEE------SVVQCEE-LKSLLRDYEQEK 840

Query: 1215 TRIMTLEKEMTSHRSHIAALKSEL 1238
               + L KE+   +S   AL+S+L
Sbjct: 841  ---VLLRKELEEIQSEKEALQSDL 861



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 78/411 (18%), Positives = 162/411 (39%), Gaps = 63/411 (15%)

Query: 3    LNTSSNTGDTQRLKIASLDVKQILKNETEL-------------DITDNLRKKLHWAKKEK 49
            + T     D+++ +   L ++  LK E E              +IT   + K+H   K  
Sbjct: 1226 VKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSE-KHKIHEHLKTS 1284

Query: 50   LEITTKHNAELASYESQIAKLRSEVE--KGEALRQSLEYDLAVARKEAGLGRRAAEERLA 107
             E   +H   L++Y+ ++  L+ E    K E    + E++    R    L ++   + ++
Sbjct: 1285 AE---QHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVL-KQQKNKSMS 1340

Query: 108  EAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYD 167
            +A     K   +   L+   ++ +   Q SQ   +      +    E D +++  N+   
Sbjct: 1341 QAETEGAK--QEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNK--- 1395

Query: 168  LLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQ 227
             +++E    E  L+E L   Q E   M+S   +T  +     E    + R +++ + +E 
Sbjct: 1396 -MLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEH 1454

Query: 228  DTAVQNMHKKVEKLETE----------------HMDCSDLLRRQTSELEF----STQREE 267
               V+ + +++ K+E +                     +L  R+ ++L      +  REE
Sbjct: 1455 RKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREE 1514

Query: 268  RLRKEFEAT---------TLRVRKLEENIEAERAAHL-ESKFNSEIIQLRIRD------- 310
                E   T         T  + +L  + E +    L  ++F  E +  ++         
Sbjct: 1515 GEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADH 1574

Query: 311  LEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLE 361
            L G L+  +A+ A  +  ++++K+E + +E   EREK  A   + K  LL+
Sbjct: 1575 LNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQ 1625


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  112 bits (281), Expect = 2e-24
 Identities = 233/1144 (20%), Positives = 469/1144 (40%), Gaps = 169/1144 (14%)

Query: 126  KTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALE 185
            K+ E EK   T     KE+  R + +L   +   +    +   L++EK+ L+  +Q   E
Sbjct: 845  KSAEAEKEMATM----KEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETE 900

Query: 186  KHQREKNEMESHIRETALEEFRLQE--EQWEAERRELQFIVQEQDTAVQNMHKKVEKLET 243
                 +   E  I+   L E +++E  E+ E E      +V ++    +N+  K   L+ 
Sbjct: 901  NLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKK----RNLEDKCSSLKR 956

Query: 244  EHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHL-------- 295
            +  D    L +   E   +  + + L +E  A    + KL +  ++ + AH         
Sbjct: 957  DIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQV 1016

Query: 296  -ESKFNSEI-----IQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHN 349
             E K N  I     ++ +  DLEG+L+ EK  +A+       ++ + K  + +    +++
Sbjct: 1017 EEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEND 1076

Query: 350  AQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKH 409
             Q+   KL   E E      +L   I++++   +   K+++  +    EL+EE+      
Sbjct: 1077 KQQIEEKLKKKEFEL----SQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTL 1132

Query: 410  QAFLVETCENNVKELESILDSF-TVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTD--YQ 466
            +A + +   +  +ELE I +     SG  ++ I  +K +   F    +++RR L +   Q
Sbjct: 1133 RAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEF----QKMRRDLEEATLQ 1188

Query: 467  NKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALIST 526
            ++   A+  +K  + +    ++ID    N++ ++ KL    KE S L  +  D  + I  
Sbjct: 1189 HEATAATLRKKQADSVAELGEQID----NLQRVKQKL---EKEKSELKMEIDDMASNIEA 1241

Query: 527  LKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQ 586
            L     N+       + Q ++ +++ ++ +Q  H D   +   L T    L      +++
Sbjct: 1242 LSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH-DLNMQKARLQTQNGEL---SHRVEE 1297

Query: 587  PEGMLDKFSWSELCAVLQ-ENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDT 645
             E ++ + + S+     Q E +   + +  +A   + H     ++  D +RE  + +++ 
Sbjct: 1298 KESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEA 1357

Query: 646  ---FTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKR-AQKFQEIAEKNMEKLN---- 697
                 +   +  ++ + W  + +   +Q +E   E +K+ AQ+ QE AE+N E  N    
Sbjct: 1358 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE-AEENTETANSKCA 1416

Query: 698  HIEKSHEQLV---------LENSH------------FKKLLSQTQREQMSLLAACALMAG 736
             +EK+ ++L          LE SH            F K+L++ +++   L  + A +  
Sbjct: 1417 SLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQK---LDESQAELEA 1473

Query: 737  ALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKG 796
            A     S S  L   R+  +E V+  E  + E + L + +S + E+  E  K  ++    
Sbjct: 1474 AQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQE---- 1529

Query: 797  LIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKE 856
                         A    K++ Q  + L   +E  +  +           +H+  K  + 
Sbjct: 1530 -------------AEKTKKLVEQEKSDLQVALEEVEGSL-----------EHEESKILRV 1565

Query: 857  QLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIG--AAKNSFAKLMD 914
            QL   Q       S+L   +I    E++ +   +   +     +L     ++N   +L  
Sbjct: 1566 QLELSQ-----VKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKK 1620

Query: 915  KIS---LVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTAS 971
            K+      ME    HS+R +   +K     R   G  K + L L   LR +  + +  A 
Sbjct: 1621 KMEGDLNEMEIQLGHSNRQMAETQKH---LRTVQGQLKDSQLHLDDALRSNEDLKEQLAI 1677

Query: 972  LQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLIT 1031
            ++++       L   E+E   + LE TE  R ++E ++ LD +  +Q+ L+    S + T
Sbjct: 1678 VERR-----NGLLLEELEEMKVALEQTERTRRLSE-QELLDASDRVQL-LHSQNTSLINT 1730

Query: 1032 HEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSL 1091
             +K E+   +                    Q +  N   E  ++EE        +A K++
Sbjct: 1731 KKKLEADIAQC-------------------QAEVENSIQESRNAEE--------KAKKAI 1763

Query: 1092 SEAKM---ELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAES-ALRMAAKDKECVANHM 1147
            ++A M   EL+++  +   L R    LEQ  + L+  + +AE  AL+   K  + + N +
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRV 1823

Query: 1148 RAVENTLHKVRDQISLSWSAASR-----NDFTLQLPKLHLETFAMEGLKGGPEVVACQAM 1202
            R +EN L   + + + +   A +      + T Q  + H     ++ L     V   QA 
Sbjct: 1824 RELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDL-----VDKLQAK 1878

Query: 1203 IKSF 1206
            +KS+
Sbjct: 1879 VKSY 1882



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 233/1127 (20%), Positives = 460/1127 (40%), Gaps = 186/1127 (16%)

Query: 37   NLRKKLHWAKKE--KLEIT-TKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARK 93
            NL  K    K++   LE+T TK   E  + E+++  L  E+        +LE +++   K
Sbjct: 946  NLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMT-------ALEENISKLTK 998

Query: 94   EAGLGRRAAEERLAEAHRIQEK---LCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEH 150
            E    + A ++ L +    ++K   L   N++L+ +T++ E +         E+ ++   
Sbjct: 999  EKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL--------EQEKKLRA 1050

Query: 151  DLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQE 210
            DLE     ++      DL M ++S ++    +   + + +K E E    +  +++ ++  
Sbjct: 1051 DLERAKRKLEG-----DLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHS 1105

Query: 211  EQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLR 270
             Q++ + +ELQ  ++E +  ++  H    K+E +  D    L R+  E+       ERL 
Sbjct: 1106 LQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSD----LARELEEI------SERLE 1155

Query: 271  KEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGA-LQVE------KASQA 323
            +   AT+ ++              +  K  +E  ++R RDLE A LQ E      +  QA
Sbjct: 1156 EASGATSAQI-------------EMNKKREAEFQKMR-RDLEEATLQHEATAATLRKKQA 1201

Query: 324  EAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVII 383
            ++VA+L    +  + V+   E+EK   +     +     E  SK+K    +IE   + + 
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDM-ASNIEALSKSK---SNIERTCRTVE 1257

Query: 384  DLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHK 443
            D    ++  ++  ++L  +L M K           + V+E ES++   T S Q       
Sbjct: 1258 DQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQ------- 1310

Query: 444  DKDKPPSFSVVLERLRRTLTDYQNKLEDASNE--EKACNELDSTKQKIDSHTKNIKELQD 501
                  + +  LE L+R + + + K ++A     + + ++ D  +++ +   +   ELQ 
Sbjct: 1311 ------ALTQQLEELKRQMEE-ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363

Query: 502  KLADVNKELSHLHTK----CADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQ 557
             L+  N E++   TK       R   +   K +L   L   E+    A    + L+K  Q
Sbjct: 1364 ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQ 1423

Query: 558  AFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRA 617
                + E+ +  L   +      C  + + +   DK     + A  ++ +D   A+L  A
Sbjct: 1424 RLQGEVEDLMRDLERSH----TACATLDKKQRNFDK-----VLAEWKQKLDESQAELEAA 1474

Query: 618  NEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLE 677
             ++ R L                T+        E++  Q     R+ K L+ + S+L  +
Sbjct: 1475 QKESRSL---------------STELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQ 1519

Query: 678  VQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGA 737
            + +  +  QE AEK  +KL   EKS  Q+ LE     ++    + E+  +L     ++  
Sbjct: 1520 IAETGKNLQE-AEKT-KKLVEQEKSDLQVALE-----EVEGSLEHEESKILRVQLELSQV 1572

Query: 738  LYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTV---EEKKQEEAKMKKKTF 794
               L  +          + E+    E  K   +  A+AL +V   E + + +A   KK  
Sbjct: 1573 KSELDRK----------VIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKM 1622

Query: 795  KGLIRIFRKGVIAVLAANRLKI-LGQSCASLFTWMESFKEGIGMLVCTG-EPQDKHKFPK 852
            +G +             N ++I LG S   +    +  +   G L  +     D  +  +
Sbjct: 1623 EGDL-------------NEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNE 1669

Query: 853  HQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKL 912
              KEQL  ++  + L        ++  + E++  + + +   R+    L+ A+       
Sbjct: 1670 DLKEQLAIVERRNGL--------LLEELEEMKVALEQTERTRRLSEQELLDAS------- 1714

Query: 913  MDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKV-NTLALKYGLRGHVPITKSTAS 971
             D++ L      LHS  +     K  L   +A    +V N++              + A+
Sbjct: 1715 -DRVQL------LHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAA 1767

Query: 972  LQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLIT 1031
            +  + L   Q   +A +ER    LE T     V +++  LD+A+ L ++  + KQ     
Sbjct: 1768 MMAEELKKEQDT-SAHLERMKKNLEQT-----VKDLQHRLDEAEQLALKGGK-KQI---- 1816

Query: 1032 HEKFESACEELNNAL----LREEQAQMLLNEQAQQLQELNYKLELHSSEEADKN-QTLGE 1086
             +K E+   EL N L     R  +A    ++  ++++E+ Y+     +EE  KN   L +
Sbjct: 1817 -QKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQ-----AEEDHKNILRLQD 1870

Query: 1087 AVKSL-SEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESA 1132
             V  L ++ K   R+ +++  Q N  L++  + +  LEE    A+ A
Sbjct: 1871 LVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIA 1917



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 140/716 (19%), Positives = 301/716 (42%), Gaps = 76/716 (10%)

Query: 2    NLNTSSNTGDTQRLKIASLDVKQILKNETELDITDNLRK--------KLHWAKKEKLEIT 53
            N+  +  T + Q  +I + D +Q     T+L    N++K        +L    +EK  + 
Sbjct: 1248 NIERTCRTVEDQFSEIKAKDEQQ-----TQLIHDLNMQKARLQTQNGELSHRVEEKESLI 1302

Query: 54   TKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQ 113
            ++      +   Q+ +L+ ++E+    + ++ + L  +R +  L R   EE       +Q
Sbjct: 1303 SQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQ 1362

Query: 114  EKLCAQNSEL-QAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKE 172
              L   NSE+ Q +T     A Q +++  +E  ++    L+E +   +  N +   L K 
Sbjct: 1363 RALSKANSEVAQWRTKYETDAIQRTEE-LEEAKKKLAQRLQEAEENTETANSKCASLEKT 1421

Query: 173  KSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQ 232
            K RL+  +++ +   +R      SH   TA      ++  ++    E +  + E    ++
Sbjct: 1422 KQRLQGEVEDLMRDLER------SH---TACATLDKKQRNFDKVLAEWKQKLDESQAELE 1472

Query: 233  NMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENI-EAER 291
               K+   L TE     +       +LE   +  + L++E    T ++ +  +N+ EAE+
Sbjct: 1473 AAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEK 1532

Query: 292  AAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFK----EVESAYEREK 347
               L  +  S+ +Q+ + ++EG+L+ E++       +L  +K+E      E +   E+ K
Sbjct: 1533 TKKLVEQEKSD-LQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLK 1591

Query: 348  HNAQESFAKL-NLLEKEYFSKN------KKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQ 400
             N+Q +   L ++L+ E  S+N      KK+  D+ E +  +   ++++   +K    +Q
Sbjct: 1592 RNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQ 1651

Query: 401  EELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRR 460
             +L   K  Q  L +   +N    E + +   +  +    + ++ ++     V LE+  R
Sbjct: 1652 GQL---KDSQLHLDDALRSN----EDLKEQLAIVERRNGLLLEELEE---MKVALEQTER 1701

Query: 461  TLTDYQNKLEDASNEEKACN----ELDSTKQKIDSHTKNIK-ELQDKLADVNKELSHLHT 515
            T    + +L DAS+  +  +     L +TK+K+++     + E+++ + +          
Sbjct: 1702 TRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKK 1761

Query: 516  KCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQ 575
               D   +   LK E     H  E+ K    Q+  +LQ        D  E+L        
Sbjct: 1762 AITDAAMMAEELKKEQDTSAHL-ERMKKNLEQTVKDLQ-----HRLDEAEQLA------- 1808

Query: 576  HLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTM 635
             L  G   I++ E  + +   +EL    +   +AL    ++   K++ + Y  +     +
Sbjct: 1809 -LKGGKKQIQKLENRVRELE-NELDVEQKRGAEAL-KGAHKYERKVKEMTYQAEEDHKNI 1865

Query: 636  RELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEK 691
              LQ         + ++++A+   + RQ +E E Q +      ++   + +E AE+
Sbjct: 1866 LRLQD--------LVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAER 1913



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 206/1051 (19%), Positives = 422/1051 (40%), Gaps = 173/1051 (16%)

Query: 251  LLRRQTSELEFSTQRE--ERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRI 308
            LL+   +E E +T +E  ER ++E   +  R ++LEE +                  + +
Sbjct: 843  LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKM------------------VSL 884

Query: 309  RDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKN 368
               +  LQ++  S+ E + D E                     E   K  +L +   +K 
Sbjct: 885  LQEKNDLQLQVQSETENLMDAE------------------ERCEGLIKSKILLE---AKV 923

Query: 369  KKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQE-----ELVMAK------------KHQA 411
            K+L E +EE++++  +L  + +  E  CS L+      EL + K            K+ +
Sbjct: 924  KELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLS 983

Query: 412  FLVETCENNVKELESILDSFTVSGQWT-SGIHKDKDKPPSFSVVLERLRRTLTDYQNKLE 470
              +   E N+ +L     S   + Q T   +  ++DK      +  +L +   D +  LE
Sbjct: 984  EEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLE 1043

Query: 471  DASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVE 530
                E+K   +L+  K+K++    ++K  Q+ + D+  +   +  K   +E  +S L+ +
Sbjct: 1044 ---QEKKLRADLERAKRKLEG---DLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAK 1097

Query: 531  LQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGM 590
            +       + E+  + Q + ++++L QA  ++ EE++   HTL   +       KQ   +
Sbjct: 1098 I-------DDEQVHSLQFQKKIKEL-QARIEELEEEIEAEHTLRAKIE------KQRSDL 1143

Query: 591  LDKFSWSELCAVLQENVDALIA--DLNRANE-----KIRHLEYICKNKSDTMRELQQTQE 643
              +    E+   L+E   A  A  ++N+  E       R LE        T   L++ Q 
Sbjct: 1144 AREL--EEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQA 1201

Query: 644  DTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSH 703
            D+  ++ EQI   +    R K++LE + SEL +E+   A   + +++      ++IE++ 
Sbjct: 1202 DSVAELGEQIDNLQ----RVKQKLEKEKSELKMEIDDMASNIEALSKSK----SNIERTC 1253

Query: 704  EQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFE 763
              +  + S  K      + EQ + L         ++ L  +   L TQ   L  +V   E
Sbjct: 1254 RTVEDQFSEIK-----AKDEQQTQL---------IHDLNMQKARLQTQNGELSHRVEEKE 1299

Query: 764  LFKLEI----RTLAQALSTVEEKKQEEAKMKKKTFKGL------IRIFRKGV--IAVLAA 811
                ++    + L Q L  ++ + +EE K K      L        + R+         A
Sbjct: 1300 SLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKA 1359

Query: 812  NRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQAL--SWLTS 869
               + L ++ + +  W   ++        T   Q   +  + +K+  + LQ    +  T+
Sbjct: 1360 ELQRALSKANSEVAQWRTKYE--------TDAIQRTEELEEAKKKLAQRLQEAEENTETA 1411

Query: 870  SDLLAAIISS----MAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPL 925
            +   A++  +      E++D++   + +   C  L     + +F K++ +    ++    
Sbjct: 1412 NSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL--DKKQRNFDKVLAEWKQKLD---- 1465

Query: 926  HSSRSITYVEKDSLVQRLAHGLHKVNTL------ALKYGLRGHVPITKSTASLQKQILGF 979
             S   +   +K+S  + L+  L K+          L+   R +  + +  + L +QI   
Sbjct: 1466 ESQAELEAAQKES--RSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAET 1523

Query: 980  TQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQG--LQMQLNEFKQSKLITHEKFES 1037
             + L  AE  ++ +  E ++ + ++ E++  L+  +   L++QL E  Q K     K   
Sbjct: 1524 GKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL-ELSQVKSELDRKVIE 1582

Query: 1038 ACEELNNALLREEQ--AQMLLNEQAQQLQELNYKLELHSSEEADKNQ---TLGEAVKSLS 1092
              EE+   L R  Q  A+ L +    +++  N  L L    E D N+    LG + + ++
Sbjct: 1583 KDEEIEQ-LKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMA 1641

Query: 1093 EAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVEN 1152
            E +  LR     L+    HL    +    L+E +   E    +  ++ E +   +   E 
Sbjct: 1642 ETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTER 1701

Query: 1153 TLHKVRDQISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGPE--VVACQAMIKSFMDVY 1210
            T  ++ +Q  L        D + ++  LH +  ++   K   E  +  CQA +++ +   
Sbjct: 1702 T-RRLSEQELL--------DASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQES 1752

Query: 1211 QLASTRIMTLEKEMTSHRSHIAALKSELHTA 1241
            + A  +    +K +T        LK E  T+
Sbjct: 1753 RNAEEK---AKKAITDAAMMAEELKKEQDTS 1780



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 108/586 (18%), Positives = 231/586 (39%), Gaps = 93/586 (15%)

Query: 45   AKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEE 104
            AK E     +K N+E+A + ++       +++ E L ++ +  LA   +EA      A  
Sbjct: 1357 AKAELQRALSKANSEVAQWRTKYET--DAIQRTEELEEAKK-KLAQRLQEAEENTETANS 1413

Query: 105  RLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQK----------WKEECRRFEHDLEE 154
            + A   + +++L  +  +L      +  A  T  +K          WK++    + +LE 
Sbjct: 1414 KCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEA 1473

Query: 155  RDNMIQNCNREYDLLMKEKSRLEK------TLQEALEKHQREKNEMESHIRETA--LEEF 206
                 ++ + E   L K ++  E+      TL+   +  Q E +++   I ET   L+E 
Sbjct: 1474 AQKESRSLSTE---LFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEA 1530

Query: 207  RLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQRE 266
               ++  E E+ +LQ  ++E + ++++   K+ +++ E       L R+   +E   + E
Sbjct: 1531 EKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKV--IEKDEEIE 1588

Query: 267  ERLRKEFEATTLRVRKLEENIEAER-AAHLESKFNSEIIQLRIRDLEGALQVEKASQAEA 325
            +  R    A       L+  I +   A  L+ K   ++ ++ I+     L       AE 
Sbjct: 1589 QLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQ-----LGHSNRQMAET 1643

Query: 326  VADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDL 385
               L  ++ + K+ +   +    + ++   +L ++E+    +N  L E++EE K  +   
Sbjct: 1644 QKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVER----RNGLLLEELEEMKVALEQT 1699

Query: 386  SKRLQYNEKSCSELQEELVMAKKHQAFLVET--------------CENNVKEL----ESI 427
             +  + +E+   +  + + +       L+ T               EN+++E     E  
Sbjct: 1700 ERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKA 1759

Query: 428  LDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDA--------------- 472
              + T +      + K++D       + + L +T+ D Q++L++A               
Sbjct: 1760 KKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKL 1819

Query: 473  -SNEEKACNELD----------------------STKQKIDSHTKNIKELQDKLADVNKE 509
             +   +  NELD                       T Q  + H KNI  LQD +  +  +
Sbjct: 1820 ENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDH-KNILRLQDLVDKLQAK 1878

Query: 510  LSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKL 555
            +     +  + E   +T     + V H  E+   +A  +ES++ KL
Sbjct: 1879 VKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKL 1924


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  111 bits (277), Expect = 5e-24
 Identities = 227/1228 (18%), Positives = 486/1228 (39%), Gaps = 191/1228 (15%)

Query: 23   KQILKNETELDITDNLRKKL---HWA------KKEKLEITTKHNAELASYESQIAKLRSE 73
            K + + E    I  N+R  +   HW       K + L  + +   E+A+ + +  K + E
Sbjct: 806  KMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDE 865

Query: 74   VEKGEALRQSLEYDLAVARKEAG---LGRRAAEERLAEAHRIQEKLCAQNSELQAKTNE- 129
            + K EA R+ LE  +    KE     L  ++  + LA+A    E+L     +L+AK  E 
Sbjct: 866  LAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEV 925

Query: 130  TEKAFQTSQ---------QKWKEECRRFEHDLEE--------------RDNMIQNCNREY 166
            TE+A +  +         +K ++EC   + D+++               +N ++N   E 
Sbjct: 926  TERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM 985

Query: 167  D-------LLMKEKSRLEKTLQEALEKHQRE----------KNEMESHIR--ETALEEFR 207
                     L KEK  L++T Q+ L+  Q E          K ++E  +   E +LE+ +
Sbjct: 986  AGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEK 1045

Query: 208  LQEEQWEAERRELQF---IVQEQDTAVQNMHKKV-EKLETEHMDCSDLLRRQTSELEFST 263
                  E  +R+L+    + QE    ++N  +++ EKLE +  + S+L+    S++E   
Sbjct: 1046 KLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLI----SKIEDEQ 1101

Query: 264  QREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNS-------EIIQLRIRDLEGALQ 316
              E +L+K+ +    R+ +L E IEAERA+  +++          E I  R+ +  GA  
Sbjct: 1102 AVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1161

Query: 317  VEKASQAEAVADLEIIKNEFKEVESAYE------REKHNAQESFAKLNLLEKEYFSKNKK 370
             +     +  A+ + ++ + +E    +E      R+KH   +S A+L           +K
Sbjct: 1162 AQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKH--ADSMAELGEQIDNLQRVKQK 1219

Query: 371  LNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDS 430
            L ++  E K    DLS   +   K+   L E++  + + Q   ++T E   + L + L +
Sbjct: 1220 LEKEKSELKMETDDLSSNAEAISKAKGNL-EKMCRSLEDQVSELKTKEEEQQRLINDLTA 1278

Query: 431  FTVSGQWTSGIH-KDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEE-KACNEL----DS 484
                 Q  +G + +  D+  +    L R ++  T    +L+    EE KA N L     S
Sbjct: 1279 QRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQS 1338

Query: 485  TKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQ 544
            ++   D   +  +E Q+  A++ + LS  +++ A       T  ++    L   +K+ AQ
Sbjct: 1339 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1398

Query: 545  AAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQ 604
              Q              +AEE +  ++       A C  +++ +  L            Q
Sbjct: 1399 RLQ--------------EAEEHVEAVN-------AKCASLEKTKQRL------------Q 1425

Query: 605  ENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQK 664
              V+ L+ D+ R+N     L+   +N    + E +Q  E+T  ++    K   S    + 
Sbjct: 1426 NEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSL-STEL 1484

Query: 665  KELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQ 724
             +++  Y E   +++   ++ + + ++  +    I +  +Q+       +K+  Q ++E+
Sbjct: 1485 FKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQI----HELEKIKKQVEQEK 1540

Query: 725  MSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQ 784
              + A                 AL      L+ +       +LE+  +   +     +K 
Sbjct: 1541 CEIQA-----------------ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD 1583

Query: 785  EEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEP 844
            EE    K+                   N  +++    ++L   + S  + + +       
Sbjct: 1584 EEIDQLKR-------------------NHTRVVETMQSTLDAEIRSRNDALRVKKKMEGD 1624

Query: 845  QDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVI-GKADPNSRICGHLLIG 903
             ++ +   +   +L      ++  +  +L     +   L D + G+ D   ++    ++ 
Sbjct: 1625 LNEMEIQLNHANRLAAESLRNYRNTQGILK---ETQLHLDDALRGQEDLKEQLA---IVE 1678

Query: 904  AAKNSFAKLMDKISLVMECIPLHSSRSITYVEKDSL-VQRLAHGLHKVNTLALKYGLRGH 962
               N     ++++   +E     + RS    E++ L        LH  NT  +    +  
Sbjct: 1679 RRANLLQAEIEELWATLE----QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK-- 1732

Query: 963  VPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLN 1022
              +    + LQ ++    Q    AE + +     +T+      E+KKE D +  L+    
Sbjct: 1733 --LENDVSQLQSEVEEVIQESRNAEEKAKKA---ITDAAMMAEELKKEQDTSAHLERMKK 1787

Query: 1023 EFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQ 1082
              +Q+            ++L + L  +E  Q+ L    +Q+Q+L  ++     E  ++ +
Sbjct: 1788 NLEQT-----------VKDLQHRL--DEAEQLALKGGKKQIQKLEARVRELEGEVENEQK 1834

Query: 1083 TLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKEC 1142
               EAVK L + +  ++       +  +++ +L+    +L+  +   +     A +    
Sbjct: 1835 RNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNA 1894

Query: 1143 VANHMRAVENTLHKVRDQISLSWSAASR 1170
              +  R +++ L +  ++  ++ S  ++
Sbjct: 1895 NLSKFRKLQHELEEAEERADIAESQVNK 1922



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 206/1079 (19%), Positives = 414/1079 (38%), Gaps = 161/1079 (14%)

Query: 17   IASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEK 76
            IA L  ++    ET     D+L+     A+++K+ I TK   +L   E Q+  L   +E+
Sbjct: 992  IAKLSKEKKALQETHQQTLDDLQ-----AEEDKVNILTKAKTKL---EQQVDDLEGSLEQ 1043

Query: 77   GEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTN--ETEKAF 134
             + LR  LE        +  L + +  +   +  ++ EKL  +  E+    +  E E+A 
Sbjct: 1044 EKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAV 1103

Query: 135  QTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEM 194
            +   QK   + +  +  +EE    I+          K++S L + L+E  E+ +      
Sbjct: 1104 EIQLQK---KIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1160

Query: 195  ESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRR 254
             + +     E  + +E +++  RR+L+    + +  V  + KK       H D    L  
Sbjct: 1161 SAQV-----ELNKKREAEFQKLRRDLEEATLQHEAMVAALRKK-------HADSMAELGE 1208

Query: 255  QTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGA 314
            Q   L+   Q+ E+ + E +  T       +++ +   A  ++K N E +   + D    
Sbjct: 1209 QIDNLQRVKQKLEKEKSELKMET-------DDLSSNAEAISKAKGNLEKMCRSLEDQVSE 1261

Query: 315  LQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNED 374
            L+ ++  Q   + DL   +   +     Y R+        ++L+  ++    + ++L   
Sbjct: 1262 LKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQ 1321

Query: 375  IEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVS 434
            +EE+ K    L+  LQ +   C  L+E+    ++ +A L         E+          
Sbjct: 1322 LEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV---------- 1371

Query: 435  GQWTSGIHKDK-DKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHT 493
             QW +    D   +        ++L + L + +  +E  + +   C  L+ TKQ++ +  
Sbjct: 1372 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAK---CASLEKTKQRLQN-- 1426

Query: 494  KNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQ 553
                E++D + DV +     +  CA  +         L      +E+ +A+   S+ E +
Sbjct: 1427 ----EVEDLMLDVERS----NAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESR 1478

Query: 554  KLSQAFHKDA---EEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDAL 610
             LS    K     EE L  L TL +                           LQ+ +  L
Sbjct: 1479 SLSTELFKVKNVYEESLDQLETLRRE-----------------------NKNLQQEISDL 1515

Query: 611  IADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQ 670
               +    ++I  LE I K       E+Q   E+          A+ S  H + K L +Q
Sbjct: 1516 TEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEE----------AEASLEHEEGKILRIQ 1565

Query: 671  YSELFLEV-QKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLA 729
                 LE+ Q +++  ++IAEK+ E+++ ++++H ++V      +  L    R +   L 
Sbjct: 1566 -----LELNQVKSEVDRKIAEKD-EEIDQLKRNHTRVV---ETMQSTLDAEIRSRNDALR 1616

Query: 730  ACALMAGALYPL-YSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAK 788
                M G L  +    + A     + L+   NT  + K     L  AL   E+ K++ A 
Sbjct: 1617 VKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLA- 1675

Query: 789  MKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKH 848
                                +   R  +L      L+  +E  +        + +  ++ 
Sbjct: 1676 --------------------IVERRANLLQAEIEELWATLEQTER-------SRKIAEQE 1708

Query: 849  KFPKHQKEQLRCLQALSWLTSSDLLAAIISSM-AELQDVIGKADPNSRICGHLLIGAAKN 907
                 ++ QL   Q  S + +   L   +S + +E+++VI ++              A+ 
Sbjct: 1709 LLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQES------------RNAEE 1756

Query: 908  SFAKLMDKISLVMECIPLHSSRSITYVEK-----DSLVQRLAHGLHKVNTLALKYGLRGH 962
               K +   +++ E +      S  ++E+     +  V+ L H L +   LALK G +  
Sbjct: 1757 KAKKAITDAAMMAEELKKEQDTS-AHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI 1815

Query: 963  VPITKSTASLQKQILGFTQR-------LHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQ 1015
              +      L+ ++    +R       L   E   + L  +  E +++V  ++  +DK Q
Sbjct: 1816 QKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQ 1875

Query: 1016 ----GLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKL 1070
                  + Q  E ++       KF     EL  A  R + A+  +N+   + +E++ K+
Sbjct: 1876 AKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKI 1934



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 166/884 (18%), Positives = 346/884 (39%), Gaps = 121/884 (13%)

Query: 339  VESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKS--- 395
            ++  + + K    + F K  LL      +++KL + I   + V      R++Y +     
Sbjct: 752  IDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAVCRGFLMRVEYQKMLQRR 811

Query: 396  ----CSELQEELVMAKKHQAF---------LVETCENNVKELESILDSFT-VSGQWTSGI 441
                C +      M  KH  +         L+++ E   KE+ ++ + F     +     
Sbjct: 812  EALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETE-KEMATMKEEFQKTKDELAKSE 870

Query: 442  HKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQD 501
             K K+       +L+         Q++ +  ++ E+ C +L   K ++++  K + E  +
Sbjct: 871  AKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAE 930

Query: 502  KLADVNKELS----HLHTKCADREALISTLKVELQNVLHCWEKEK----AQAAQSESELQ 553
            +  ++N EL+     L  +C++ +  I  L++ L  V    EKEK     +      E+ 
Sbjct: 931  EEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV----EKEKHATENKVKNLTEEMA 986

Query: 554  KLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIAD 613
             L +   K ++EK     T +Q  +      +    +L K         L++ VD L   
Sbjct: 987  GLDETIAKLSKEKKALQET-HQQTLDDLQAEEDKVNILTKAK-----TKLEQQVDDLEGS 1040

Query: 614  LNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSE 673
            L +  +    LE   + K     +L+  QE T     ++ +  E     +KKE E+  S 
Sbjct: 1041 LEQEKKLRMDLE---RAKRKLEGDLKLAQESTMDMENDKQQLDEKL---EKKEFEI--SN 1092

Query: 674  LFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKL------LSQTQREQMSL 727
            L  +++       ++ +K  E    IE+  E++  E +   K       LS+   E    
Sbjct: 1093 LISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISER 1152

Query: 728  LAACALMAGALYPLYSRSCA--LSTQRDF----LQEQVNTFELFKLEIRTLAQALSTVEE 781
            L        A   L  +  A     +RD     LQ +     L K    ++A+    ++ 
Sbjct: 1153 LEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDN 1212

Query: 782  KKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCT 841
             ++ + K++K+  K  +++    +     ++  + + ++  +L     S ++ +  L   
Sbjct: 1213 LQRVKQKLEKE--KSELKMETDDL-----SSNAEAISKAKGNLEKMCRSLEDQVSELKTK 1265

Query: 842  GEPQDK---HKFPKHQKEQLRCLQALSWLTSSDLLAAIIS-----SMAELQDVIGKADPN 893
             E Q +       +  + Q    +    L   D L + +S     S  +++++  + +  
Sbjct: 1266 EEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEE 1325

Query: 894  SRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTL 953
            ++         AKN+ A  +   S   +C  L       Y E+      L   L K N+ 
Sbjct: 1326 TK---------AKNALAHALQ--SSRHDCDLLREQ----YEEEQEGKAELQRALSKANSE 1370

Query: 954  ALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDK 1013
              ++  +      + T  L++      QRL  AE           E   +VN     L+K
Sbjct: 1371 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE-----------EHVEAVNAKCASLEK 1419

Query: 1014 A-QGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLEL 1072
              Q LQ ++ +     ++  E+  +AC  L+    ++     +L+E  Q+ +E   +LE 
Sbjct: 1420 TKQRLQNEVEDL----MLDVERSNAACAALDK---KQRNFDKVLSEWKQKYEETQAELEA 1472

Query: 1073 HSSEEADKNQTLGEAVKSLSEAKME----LRRKDQSLRQLNRHLT-----------QLEQ 1117
               E    +  L + VK++ E  ++    LRR++++L+Q    LT           +LE+
Sbjct: 1473 SQKESRSLSTELFK-VKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEK 1531

Query: 1118 DKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQI 1161
             K+++E+   + ++AL  A    E     +  ++  L++V+ ++
Sbjct: 1532 IKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1575



 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 153/826 (18%), Positives = 322/826 (38%), Gaps = 102/826 (12%)

Query: 516  KCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQ 575
            K A+ E  ++T+K E Q       K K + A+SE++         K+ EEK+  L  L +
Sbjct: 844  KSAETEKEMATMKEEFQ-------KTKDELAKSEAK--------RKELEEKMVTL--LKE 886

Query: 576  HLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYIC------- 628
                   +  + + + D     E C  L +N   L A +    E+    E I        
Sbjct: 887  KNDLQLQVQSEADSLADA---EERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKK 943

Query: 629  KNKSDTMRELQQTQED---TFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKF 685
            +   D   EL++  +D   T  KV ++  A E+      +E+     E   ++ K  +  
Sbjct: 944  RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA-GLDETIAKLSKEKKAL 1002

Query: 686  QEIAEKNME-------KLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGAL 738
            QE  ++ ++       K+N + K+  +L  +    +  L Q ++ +M L  A   + G L
Sbjct: 1003 QETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL 1062

Query: 739  YPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLI 798
                  +  +   +  L E++   E        ++  +S +E+++  E +++KK  +   
Sbjct: 1063 KLAQESTMDMENDKQQLDEKLEKKEF------EISNLISKIEDEQAVEIQLQKKIKELQA 1116

Query: 799  RIFRKGV-IAVLAANRLKILGQSCASLFTWMESFKEGIGMLV-CTGEPQDKHKFPKHQKE 856
            RI   G  I    A+R K   Q  + L   +E   E +      T    + +K  + + +
Sbjct: 1117 RIEELGEEIEAERASRAKAEKQR-SDLSRELEEISERLEEAGGATSAQVELNKKREAEFQ 1175

Query: 857  QLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKI 916
            +LR     + L    ++AA+    A+    +G+   N        +   K    K  +K 
Sbjct: 1176 KLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDN--------LQRVKQKLEK--EKS 1225

Query: 917  SLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHV--PITKSTASLQK 974
             L ME   L S+       K +L +       +V+ L  K   +  +   +T   A LQ 
Sbjct: 1226 ELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQT 1285

Query: 975  QILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDK--------AQGLQM------- 1019
            +   ++++L   +     L        + + E+K +L++        A  LQ        
Sbjct: 1286 EAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDL 1345

Query: 1020 ---QLNEFKQSKLITHEKFESACEEL--------NNALLREEQAQMLLNEQAQQLQELNY 1068
               Q  E ++ K         A  E+         +A+ R E+ +    + AQ+LQE   
Sbjct: 1346 LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE 1405

Query: 1069 KLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHD 1128
             +E  +++ A   +T       + +  +++ R + +   L++     ++     ++   +
Sbjct: 1406 HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEE 1465

Query: 1129 AESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASRN------DFTLQLPKLHL 1182
             ++ L  + K+   ++  +  V+N   +  DQ+  +    ++N      D T Q+ +   
Sbjct: 1466 TQAELEASQKESRSLSTELFKVKNVYEESLDQLE-TLRRENKNLQQEISDLTEQIAEGGK 1524

Query: 1183 ETFAMEGLKGGPEVVAC--QAMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHT 1240
            +   +E +K   E   C  QA ++      +    +I+ ++ E+         +KSE+  
Sbjct: 1525 QIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQ-------VKSEVDR 1577

Query: 1241 ACLRENASLQSIGSRDHSNLSIPSRAPLPADTTGIGDFLPLKAELD 1286
                ++  +  +  R+H+ +    ++ L A+     D L +K +++
Sbjct: 1578 KIAEKDEEIDQL-KRNHTRVVETMQSTLDAEIRSRNDALRVKKKME 1622



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 69/360 (19%), Positives = 155/360 (43%), Gaps = 43/360 (11%)

Query: 16   KIASLD--VKQILKNETELDITDNLRKKLHW---AKKEKLEITTKHNAELASYESQIA-- 68
            KIA  D  + Q+ +N T   + + ++  L     ++ + L +  K   +L   E Q+   
Sbjct: 1578 KIAEKDEEIDQLKRNHTR--VVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHA 1635

Query: 69   -KLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKT 127
             +L +E  +     Q +  +  +   +A  G+   +E+LA   R    L A+  EL A  
Sbjct: 1636 NRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATL 1695

Query: 128  NETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKH 187
             +TE++ + ++Q+  +   R +  L  ++  + N  ++   L  + S+L+  ++E +++ 
Sbjct: 1696 EQTERSRKIAEQELLDASERVQL-LHTQNTSLINTKKK---LENDVSQLQSEVEEVIQES 1751

Query: 188  QREKNEMESHIRETALEEFRLQEEQW------------------------EAERRELQF- 222
            +  + + +  I + A+    L++EQ                         EAE+  L+  
Sbjct: 1752 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1811

Query: 223  --IVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRV 280
               +Q+ +  V+ +  +VE  +  + +    LR+    ++  T + E  RK        V
Sbjct: 1812 KKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLV 1871

Query: 281  RKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVE 340
             KL+  +++ +    E++  S     + R L+   ++E+A +   +A+ ++ K   K  E
Sbjct: 1872 DKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQH--ELEEAEERADIAESQVNKLRVKSRE 1929


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  110 bits (276), Expect = 7e-24
 Identities = 248/1200 (20%), Positives = 489/1200 (40%), Gaps = 164/1200 (13%)

Query: 59   ELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQE---K 115
            ++   + +IA L  E +K +   Q+LE +     K   L + + ++   E   +QE   K
Sbjct: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENE-----KNTLLSQISTKD--GELKMLQEEVTK 1893

Query: 116  LCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREY-------DL 168
            +   N ++Q + +   K  +T++++  +   R  + L E +  I N  ++        +L
Sbjct: 1894 MNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNEL 1953

Query: 169  LMKEKSRLEKTLQEALEKHQ---REKNEMESHIRETALEEFR--LQEEQWEAERRELQFI 223
            L  E   L+K + E  E+ Q   +EK ++ES IR+  LE+ +   +E   ++  +ELQ +
Sbjct: 1954 LESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQEL 2013

Query: 224  VQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKL 283
            ++E+   V    K+++K    + +    L R    LEF  Q E   +K+ E T       
Sbjct: 2014 LKEKQQEV----KQLQKDCIRYQEKISALERTVKALEF-VQTES--QKDLEIT------- 2059

Query: 284  EENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFK-EVESA 342
            +EN+   +A     K  +E+   ++      L   ++  A  +AD   +K E +   ES 
Sbjct: 2060 KENL--AQAVEHRKKAQAELASFKV-----LLDDTQSEAARVLADNLKLKKELQSNKESV 2112

Query: 343  YEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEE 402
              + K   ++   +L   E+++  + K + E ++  ++  + L       E++  E+Q  
Sbjct: 2113 KSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHL-------EETIGEIQVT 2165

Query: 403  LVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTL 462
            L    K    L E  ++ V +L +   S        S +  D+D+    +   E  R+  
Sbjct: 2166 LNKKDKEVQQLQENLDSTVTQLAAFTKSM-------SSLQDDRDRVIDEAKKWE--RKFS 2216

Query: 463  TDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKEL--SHLHTKCADR 520
               Q+K E+   +E  C+ L    +++  H + +K    +L + +K++  S   T+   +
Sbjct: 2217 DAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRL-EHDKQIWESKAQTEVQLQ 2275

Query: 521  EALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHL--- 577
            + +  TL+ E + +L   E+ +     S++EL KL     K  +++LT L    +     
Sbjct: 2276 QKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESEL-KSLKDQLTDLSNSLEKCKEQ 2334

Query: 578  ---VAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDT 634
               + G +  ++ +    KFS+ +           L  DL  + E    L      K   
Sbjct: 2335 KGNLEGIIRQQEADIQNSKFSYEQ-----------LETDLQASRELTSRLHEEINMKEQK 2383

Query: 635  MRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNME 694
            +  L   +E+       +++ Q     ++ + L  Q  E  + +++  +K  +   + ME
Sbjct: 2384 IISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLME 2443

Query: 695  KLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRD- 753
             L  I+K + Q   +   F K +S  Q ++  ++       G    L  R  ++  ++D 
Sbjct: 2444 TLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIV-------GDYQQLEERHLSIILEKDQ 2496

Query: 754  FLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANR 813
             +QE        K EIR L    S +++   E AK+  +  +   R     VI +  + +
Sbjct: 2497 LIQEAAAENNKLKEEIRGLR---SHMDDLNSENAKLDAELIQ--YREDLNQVITIKDSQQ 2551

Query: 814  LKILG---QSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSS 870
             ++L    Q    L       +E +       E   +      +++Q    +  S   S 
Sbjct: 2552 KQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSI 2611

Query: 871  DLLAAIISSMAELQDVIGKADPNSRICGHLL--IGAAKNSFAKLMDKISLVMECIPLHSS 928
              L   ++++ E +  +G      ++    +  + A  +S  K + ++   + C+   ++
Sbjct: 2612 SQLTRQVTALQE-EGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAA 2670

Query: 929  RSITYVEKDSLVQRLAHGLH--------------KVNTLA--LKYGLRGHVPITKSTASL 972
            + +  +E D L + L H  H              +V  LA  L    +  + +TK    L
Sbjct: 2671 KKVGEIE-DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGL 2729

Query: 973  QKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELD--KAQGL-----QMQLNEFK 1025
              QI  F + + + +  R     E+ E KR  +   KEL   K QGL        L+E  
Sbjct: 2730 TAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA 2789

Query: 1026 QSKLITHEKFESACEELNNALLREEQAQMLLNEQAQ----QLQELNYKL----------- 1070
             S   T E   S  E+LN  LL +++  + L+ Q +    Q+Q  +  +           
Sbjct: 2790 FSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLW 2849

Query: 1071 ----ELHSSEEADKN------------QTLGEAVKSLSEAK----MELRRKDQSLRQLNR 1110
                +   SEE  +             Q+L +A+ SL   +     EL+   Q   Q+N+
Sbjct: 2850 NELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909

Query: 1111 HLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASR 1170
             +T+L   K +L+E   D   A ++    +E +     + ++ LH++R + S SW    R
Sbjct: 2910 EITELHPLKAQLQE-YQDKTKAFQIM---QEELRQENLSWQHELHQLRMEKS-SWEIHER 2964



 Score =  105 bits (261), Expect = 4e-22
 Identities = 238/1193 (19%), Positives = 495/1193 (41%), Gaps = 173/1193 (14%)

Query: 40   KKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARK---EAG 96
            K+L    KEK +   +   +   Y+ +I+ L   V+  E ++   + DL + ++   +A 
Sbjct: 2008 KELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAV 2067

Query: 97   LGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERD 156
              R+ A+  LA    + +   ++ + + A   + +K  Q++++  K + ++ + DLE R 
Sbjct: 2068 EHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERR- 2126

Query: 157  NMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETAL------EEFRLQE 210
              ++    ++   +KEK    K +QE L+  +REK  +E  I E  +      +E +  +
Sbjct: 2127 --LEQAEEKH---LKEK----KNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQ 2177

Query: 211  EQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLR 270
            E  ++   +L    +   +   +  + +++ +      SD ++ +  E+         L+
Sbjct: 2178 ENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLK 2237

Query: 271  KEFEATTLRVRKLEENIEAERAAH----LESKFNSEI-IQLRIRDLEGALQVEKASQAEA 325
             +    ++ + +L+ NI   R  H     ESK  +E+ +Q ++ D       E  SQ E 
Sbjct: 2238 DQLRQMSIHMEELKINI--SRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEE 2295

Query: 326  VADL-EIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKN------KKLNEDIEEQ 378
               L    +NE  ++ES  +  K    +     N LEK    K       ++   DI+  
Sbjct: 2296 TRHLYHSSQNELAKLESELKSLKDQLTD---LSNSLEKCKEQKGNLEGIIRQQEADIQNS 2352

Query: 379  KKVIIDLSKRLQYNEKSCSELQEEL---------VMAKKHQAFLVETCE------NNVKE 423
            K     L   LQ + +  S L EE+         +++ K +A  V   E        +KE
Sbjct: 2353 KFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKE 2412

Query: 424  LESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELD 483
            LE++L                  +    ++VLE   +   D  N+L +     K   E  
Sbjct: 2413 LENLL-----------------SQEEEENIVLEEENKKAVDKTNQLMETLKTIK--KENI 2453

Query: 484  STKQKIDSHTKNIKELQ---DKLADVNKELSHLHTK-CADREALI-------STLKVELQ 532
              K ++DS  K++  LQ   D++    ++L   H     +++ LI       + LK E++
Sbjct: 2454 QQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIR 2513

Query: 533  NVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLD 592
             +    +   ++ A+ ++EL +    + +D  + +T   +  + L+   V ++Q + + +
Sbjct: 2514 GLRSHMDDLNSENAKLDAELIQ----YREDLNQVITIKDSQQKQLLE--VQLQQNKELEN 2567

Query: 593  KFSWSELCAVLQENVDALIADLNRA--------NEKIRHLEYICKNKSDTMRELQQTQED 644
            K+  ++L   L+E+ +A   DL R+         +  + +E +  + S   R++   QE+
Sbjct: 2568 KY--AKLEEKLKESEEA-NEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE 2624

Query: 645  -TFTKVAEQIKAQESCWHR--------QKKELELQYSELFLEVQKRAQKFQEIAEKNMEK 695
             T      Q+K +E   HR        QK+  EL+  EL    ++ A+K  EI +K  ++
Sbjct: 2625 GTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELE-EELVCVQKEAAKKVGEIEDKLKKE 2683

Query: 696  LNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFL 755
            L H+   H+  ++ N       ++T  E++      A +A  L  +  +   ++ +   L
Sbjct: 2684 LKHLH--HDAGIMRNE------TETAEERV------AELARDLVEMEQKLLMVTKENKGL 2729

Query: 756  QEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLK 815
              Q+ +F       R+++   ++ +   +E  ++K+K    L  + +     +L   R  
Sbjct: 2730 TAQIQSFG------RSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDA 2783

Query: 816  ILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAA 875
            +L ++  S+ +  E+    +  L    +   K +   H   QL          S + + +
Sbjct: 2784 LLSETAFSMNSTEENSLSHLEKL--NQQLLSKDEQLLHLSSQLE--------DSYNQVQS 2833

Query: 876  IISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVE 935
               +MA LQ        N R   HL     K   ++   + S      P  S   +  ++
Sbjct: 2834 FSKAMASLQ--------NER--DHLWNELEKFRKSEEGKQRSAAQ---PSTSPAEVQSLK 2880

Query: 936  K--DSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSL 993
            K   SL       L ++  L  +Y L+ +  IT+    L+ Q+  +  +  A ++ +  L
Sbjct: 2881 KAMSSLQNDRDRLLKELKNLQQQY-LQINQEITE-LHPLKAQLQEYQDKTKAFQIMQEEL 2938

Query: 994  RLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQ 1053
            R E   ++  +++++ E       ++     K+  L+     +     L N L+RE    
Sbjct: 2939 RQENLSWQHELHQLRME---KSSWEIHERRMKEQYLMAISDKDQQLSHLQN-LIRE---- 2990

Query: 1054 MLLNEQAQQLQELNYKLELHSSEEA----DKNQTLGEAVK----SLSEAKMELRRKDQSL 1105
              L   + Q Q L  + +  +S E     D +Q L    +     L+++  E+ +K+  +
Sbjct: 2991 --LRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRI 3048

Query: 1106 RQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVR 1158
            +QLN + +QL ++K  L   + D   +LR   +    + NH   +E  + +++
Sbjct: 3049 QQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQ 3101



 Score =  103 bits (258), Expect = 8e-22
 Identities = 255/1327 (19%), Positives = 508/1327 (38%), Gaps = 181/1327 (13%)

Query: 25   ILKNETELDITDNLRKKLHWAKKEKLEITTK-HNAELASYESQIAKLRSEVEK-GEALR- 81
            + K +TE+   ++L K LH     +LE+  K H+  +   + ++ +++ + E+ GE  R 
Sbjct: 1422 LTKIQTEIIEQEDLIKALH----TQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477

Query: 82   -QSLEYDLAVA---RKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTS 137
             Q ++  L  A   RKEA    ++ +E L+ A    E+L    ++++++ +   K   T 
Sbjct: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537

Query: 138  -------QQKWKEECRRFEHDLEERDNMIQNCNR---EYDLLMKEKSRLEKTLQEALEKH 187
                   Q++  +     +  L E  ++  +C       + L ++K +L K ++      
Sbjct: 1538 LGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597

Query: 188  QREKNEMESHIRETALE-EFRLQE-EQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEH 245
              E  E +   +E   E E  LQ  E    E   +Q +V+      Q ++ K+   E   
Sbjct: 1598 IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657

Query: 246  MDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERA-AHLESKFNSEII 304
             +    L+    E+E   + +E++RK  ++   ++ +LEE  +  RA  H       E +
Sbjct: 1658 KETEKQLQEAEQEME---EMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECM 1714

Query: 305  QLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYER---EKHNAQESFAKLNLLE 361
            +  +           +S A    +LE +K E++ +   ++    EK +  E    L    
Sbjct: 1715 ETLL-----------SSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763

Query: 362  KEYFSK--NKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQ-------EELVMAKKHQAF 412
            +   SK  N +  E  + Q  V  + ++ +    +    L         E V + K    
Sbjct: 1764 EGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANP 1823

Query: 413  LVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDY----QNK 468
             V    ++  E+ + L       +  +G+ ++K K   FS  LE  + TL         +
Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGE 1883

Query: 469  LEDASNEEKACNELDSTKQKIDSHTKNIKE------------LQDKLADVNKELSHLHTK 516
            L+    E    N L+   Q+  S    +KE            L ++LA++N  + +    
Sbjct: 1884 LKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQD 1943

Query: 517  CADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQH 576
              D +     L+ E++N+  C  + + +  Q   E  K+     K+  EK+         
Sbjct: 1944 VTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQ----- 1998

Query: 577  LVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMR 636
                    K+P          EL    Q+ V  L  D  R  EKI  LE   K       
Sbjct: 1999 --------KEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQT 2050

Query: 637  ELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLE---------------VQKR 681
            E Q+  E T   +A+ ++      HR+K + EL   ++ L+               ++K 
Sbjct: 2051 ESQKDLEITKENLAQAVE------HRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKE 2104

Query: 682  AQKFQEIAEKNMEKLNH-----IEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAG 736
             Q  +E  +  M++ +      +E++ E+ + E  + ++ L   +RE++ L      +  
Sbjct: 2105 LQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEI-- 2162

Query: 737  ALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQ---EEAKMKKKT 793
                       L+ +   +Q+     +    ++    +++S++++ +    +EAK  ++ 
Sbjct: 2163 --------QVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERK 2214

Query: 794  FKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKH 853
            F   I+   + +   L  +   +L      +   ME  K  I  L    +  +     + 
Sbjct: 2215 FSDAIQSKEEEIR--LKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEV 2272

Query: 854  QKEQLRC-------LQALSWL--------TSSDLLAAIISSMAELQDVIGKADPNSRICG 898
            Q +Q  C        + LS L        +S + LA + S +  L+D +     +   C 
Sbjct: 2273 QLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCK 2332

Query: 899  HL---LIGAAKNSFAKLMD-KISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLA 954
                 L G  +   A + + K S       L +SR +T    + +       + +   ++
Sbjct: 2333 EQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEI------NMKEQKIIS 2386

Query: 955  LKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSV--NEMKKELD 1012
            L  G    + +  + A L++Q        H  E++     L   E +  V   E KK +D
Sbjct: 2387 LLSGKEEAIQV--AIAELRQQ--------HDKEIKELENLLSQEEEENIVLEEENKKAVD 2436

Query: 1013 KAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLEL 1072
            K   L   L   K+  +    + +S  + +++          L N++ + + +     E 
Sbjct: 2437 KTNQLMETLKTIKKENIQQKAQLDSFVKSMSS----------LQNDRDRIVGDYQQLEER 2486

Query: 1073 HSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESA 1132
            H S   +K+Q + EA    ++ K E+R     +  LN    +L+ +  +  E+++   + 
Sbjct: 2487 HLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITI 2546

Query: 1133 LRMAAKD-KECVANHMRAVENTLHKVRDQISLSWSA---ASRNDFTLQLPKLHLETFAME 1188
                 K   E      + +EN   K+ +++  S  A     R+   LQ  K  L    +E
Sbjct: 2547 KDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSK-EIE 2605

Query: 1189 GLKGGPEVVACQAMIKSFMDVYQLASTRIMTLEKEM-------TSHRSHIAALKSELHTA 1241
             LK     +  Q           L   ++   E+E+       +S +  IA L+ EL   
Sbjct: 2606 SLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEEL--V 2663

Query: 1242 CLRENAS 1248
            C+++ A+
Sbjct: 2664 CVQKEAA 2670



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 255/1375 (18%), Positives = 547/1375 (39%), Gaps = 219/1375 (15%)

Query: 12   TQRLKIASLDVKQ-ILKNETELD-ITDNLRKKLHWAKKEKLEITTKH-NAELASYESQIA 68
            T + +   + +KQ I + E EL  I  +L +KL  A +E+ +   K  N  L    +QI 
Sbjct: 1052 TSKCQEIEIYLKQTISEKEVELQHIRKDLEEKL--AAEEQFQALVKQMNQTLQDKTNQID 1109

Query: 69   KLRSEVEKGEALRQSLEYD---------LAVARKEAGLGRRAAEERLAEAHRIQEKLCA- 118
             L++E+ + +A+ Q L            +A+ ++   +              ++EK+ A 
Sbjct: 1110 LLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILAL 1169

Query: 119  --QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKS-- 174
              +  +LQ K  E   + +   +K +E+ R    +L+++ +       ++D   KE    
Sbjct: 1170 EKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENI 1229

Query: 175  -----RLEKTLQEALEKHQREKNEMESHIRETALEE--FRLQEEQ-------------WE 214
                 +L+  ++E+++      ++ ES      LEE  F+  E+              W 
Sbjct: 1230 GDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWP 1289

Query: 215  AERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFE 274
            +   +   +  +  T+V  +  +++++E E ++    +   TSEL   ++   +L+++  
Sbjct: 1290 SHSEDASAL--QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQIN 1347

Query: 275  ATTLRVRKLEE-NIEAE-RAAHLESKFNSEIIQL----RIRDLEGALQVEKASQAEAVAD 328
               L +  L+  + EAE  A  L+ K  S  +Q+     +R+L+  L   +   ++   D
Sbjct: 1348 KQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEED 1407

Query: 329  LEIIKNEFKEVESAYEREKHNA--QESFAK-----LNLLEKEYFSKNKKLNEDIEEQKKV 381
            +  +  +  E E+A  + +     QE   K     L +  KE+  + K+L  ++ E K+ 
Sbjct: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQK 1467

Query: 382  IIDLSKRLQYNEKSCSELQEELVMAK---KHQAFLVETCENNVKELESILDSFTVSGQWT 438
              ++ +  +  ++   +LQ  L+  K   K    L E        +E +  S        
Sbjct: 1468 PEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQV 1527

Query: 439  SGIHKDKDKPPSFSVVLERLR--------RTLTDYQNKLEDASNEEKACNELDSTKQKID 490
            S  +K+KD       +L+  R        R+L + Q+      + + A   L   K+K+ 
Sbjct: 1528 SAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLV 1587

Query: 491  SHTKNIK--------ELQDKLADVNKELS-------HLHTKCADREALISTLKVELQNVL 535
               +++K        E Q+K  ++ KE         ++  +    + ++  ++ E Q + 
Sbjct: 1588 KEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELY 1647

Query: 536  HCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFS 595
                  +A   ++E +LQ+  Q   +  E+   F  +  Q ++                 
Sbjct: 1648 GKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILE---------------- 1691

Query: 596  WSELCAVLQENVDALIADLNRANEKIRH-LEYICKNKSDTMRELQQT--QEDTFTKVAEQ 652
                   L+E  D L A+++ A +  +  +E +  + +    EL++   + +T +K  + 
Sbjct: 1692 -------LEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQS 1744

Query: 653  IKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSH 712
            + +++     + ++L+ Q     +E     Q   E  EK+  + N  E+  + +  E   
Sbjct: 1745 LMSEKDSLSEEVQDLKHQ-----IEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEE 1799

Query: 713  FKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQ-EQVNTFELFKLEIRT 771
               L        MS    C+    +     ++S   +  +DF   +++N +     +I  
Sbjct: 1800 QDSL-------SMSTRPTCSESVPS-----AKSANPAVSKDFSSHDEINNY---LQQIDQ 1844

Query: 772  LAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAAN--RLKILGQSCASLFTWME 829
            L + ++ +EE+KQ     K K F   +   +  +++ ++     LK+L +    +    +
Sbjct: 1845 LKERIAGLEEEKQ-----KNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQ 1899

Query: 830  SFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIG- 888
              +E +  +    E  ++ K                     DL   +++ +AEL   IG 
Sbjct: 1900 QIQEELSRVTKLKETAEEEK--------------------DDLEERLMNQLAELNGSIGN 1939

Query: 889  --KADPNSRICGHLLIGAAKNSFAKLMD----KISLVMECIPLHSSRSITYVEKDSLVQR 942
              +   +++I   LL    KN    + +    K  LV E   + S     Y+EK    Q+
Sbjct: 1940 YCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK 1999

Query: 943  LAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKR 1002
                 +K +   L+  L+      K    LQK  + + +++ A E   ++L    TE ++
Sbjct: 2000 EPG--NKSHAKELQELLKEKQQEVKQ---LQKDCIRYQEKISALERTVKALEFVQTESQK 2054

Query: 1003 SVNEMKKELDKA----QGLQMQLNEFKQSKLITHEKFESACEELNNALLREE-------- 1050
             +   K+ L +A    +  Q +L  FK   L+   + E+A    +N  L++E        
Sbjct: 2055 DLEITKENLAQAVEHRKKAQAELASFKV--LLDDTQSEAARVLADNLKLKKELQSNKESV 2112

Query: 1051 QAQML-----LNEQAQQLQELNYKLELHSSEEADK--------NQTLGEAVKSLSEAKME 1097
            ++QM      L  + +Q +E + K + +  E+ D          +T+GE   +L++   E
Sbjct: 2113 KSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKE 2172

Query: 1098 LRRKDQS-------LRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAV 1150
            +++  ++       L    + ++ L+ D+ R+ +     E     A + KE     +R  
Sbjct: 2173 VQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKE---EEIRLK 2229

Query: 1151 ENTLHKVRDQI---SLSWSAASRNDFTLQLPK----------LHLETFAMEGLKGGPEVV 1197
            E+    ++DQ+   S+       N   L+  K          + L+    + L+G  + +
Sbjct: 2230 EDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKEL 2289

Query: 1198 ACQAMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTACLRENASLQSI 1252
              Q  ++    +Y  +   +  LE E+ S +  +  L + L   C  +  +L+ I
Sbjct: 2290 LSQ--LEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLE-KCKEQKGNLEGI 2341



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 232/1179 (19%), Positives = 470/1179 (39%), Gaps = 187/1179 (15%)

Query: 51   EITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEA-GLGRRAAEERLAEA 109
            E  +KH+      E +I K++ ++++ E L  +L+  L  A+ E         EE +   
Sbjct: 130  EQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMK 189

Query: 110  HRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLL 169
             ++QEK     S LQA+ ++T+ A Q +QQ  +E+  RFE  +   ++ +     + D+ 
Sbjct: 190  QQLQEKE-EFISTLQAQLSQTQ-AEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVE 247

Query: 170  MKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDT 229
             + + +L + LQ  LE+H+      ES +    + +  LQ+E   AE+R    I+ +Q  
Sbjct: 248  TEMQQKL-RVLQRKLEEHE------ESLVGRAQVVDL-LQQELTAAEQRNQ--ILSQQLQ 297

Query: 230  AVQNMHKKVEK-LETEHMDCSDLLRRQTSE-----LEFSTQREE--RLRKEFEATTLRVR 281
             ++  H  +   +ETE  +   LL +   E     L F   +EE   L ++FE       
Sbjct: 298  QMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQA 357

Query: 282  KLEEN---IEAERAAHLESKFNSEIIQLRI--RDLEGALQVEKASQAEAVADLEIIKNEF 336
            +LE     +E +  A +E K  S I+ L+   ++L+ A    K   ++ + D    KNE 
Sbjct: 358  ELESRYSALEQKHKAEMEEK-TSHILSLQKTGQELQSACDALKDQNSKLLQD----KNE- 411

Query: 337  KEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIE----EQKKVIIDLSKRLQYN 392
                         A +S   +  LE +   K+K++++ +     +Q +     S    YN
Sbjct: 412  ------------QAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYN 459

Query: 393  EKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFS 452
            E + +  +E +   +K            V ELE+   +  +S      +  + +K  S  
Sbjct: 460  EGTQAVTEENIASLQKR-----------VVELENEKGALLLSSIELEELKAENEKLSS-- 506

Query: 453  VVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKE-LQDKLADVNKELS 511
                  + TL + QN+  +A  E    + +D   ++  S  ++ ++ L++  +  +KELS
Sbjct: 507  ------QITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELS 560

Query: 512  HLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLH 571
             L  +  + +  I+ LK++LQ                    ++  +A H+  ++K     
Sbjct: 561  VLLLEMKEAQEEIAFLKLQLQG-------------------KRAEEADHEVLDQK----- 596

Query: 572  TLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNK 631
             + Q    G   IK    + D      L    + ++ A+  +      + R  E I  N 
Sbjct: 597  EMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLN- 655

Query: 632  SDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEK 691
             D   EL+ T++D      + + A        + ELE   S++ LE++    K QEI EK
Sbjct: 656  -DAGVELKSTKQDG----DKSLSAVPDIGQCHQDELERLKSQI-LELELNFHKAQEIYEK 709

Query: 692  NMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQ 751
            N+++      +  QL+ E   FKK                           S   ALS +
Sbjct: 710  NLDEKAKEISNLNQLIEE---FKKNADNNS---------------------SAFTALSEE 745

Query: 752  RDFLQEQVNTFEL---FKLEIRTLAQALSTVEEKKQEEAK--------MKKKTFKGLIRI 800
            RD L  QV    +    + +++ L   L+  E +++ + +        + ++     I  
Sbjct: 746  RDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEA 805

Query: 801  FRKGVIAVLAANRL---KILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQ 857
              K V   +  N L   ++     ++L   ++S  +     V  G  + +H   K ++  
Sbjct: 806  KSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS 865

Query: 858  LRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKIS 917
                Q    +T  D L  ++    +++ +    +   +    +     +       +K S
Sbjct: 866  QALSQKELEITKMDQL--LLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS 923

Query: 918  LVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKY------GLRGHVPITKSTAS 971
            L +E   L    ++    +++  +++       + L   Y      G      +      
Sbjct: 924  LGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDL 983

Query: 972  LQKQILGFTQRLHAAEVERRSLRLEVTEFKRSV----NEMKKELDKAQGLQMQLNEFKQS 1027
            L+K+     ++L AA + R+ L   V+  +  +    +E KKE+  ++  + ++ E K++
Sbjct: 984  LKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKEN 1043

Query: 1028 KLITHEKFESACEE----------------------LNNALLREEQAQMLLNEQAQQLQE 1065
            K  + +   S C+E                      L   L  EEQ Q L+ +  Q LQ+
Sbjct: 1044 KEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQD 1103

Query: 1066 LNYKLELHSSEEADKNQTLGEAVKSLSEA----KMELRRKDQSLR------------QLN 1109
               +++L  +E ++    + + + S ++A     + L ++   +             +L 
Sbjct: 1104 KTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELE 1163

Query: 1110 RHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMR 1148
              +  LE++K +L++ + +A ++ +   K  +    H+R
Sbjct: 1164 EKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR 1202



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 152/785 (19%), Positives = 314/785 (40%), Gaps = 115/785 (14%)

Query: 29   ETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDL 88
            E +++I+     K  W  K + E+  +      + + +  +L S++E+   L  S + +L
Sbjct: 2249 ELKINISRLEHDKQIWESKAQTEVQLQQKV-CDTLQGENKELLSQLEETRHLYHSSQNEL 2307

Query: 89   AVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRF 148
            A    E     ++ +++L +     EK   Q   L+    + E   Q S+  +++     
Sbjct: 2308 AKLESEL----KSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQ----L 2359

Query: 149  EHDLEERDNMIQNCNREYD--------LLMKEKSRLEKTLQEALEKHQREKNEMESHIRE 200
            E DL+    +    + E +        LL  ++  ++  + E  ++H +E  E+E+ + +
Sbjct: 2360 ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQ 2419

Query: 201  TALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELE 260
               E   L+EE  +A  +  Q +   +    +N+ +K + L++     S L   +   + 
Sbjct: 2420 EEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQ-LDSFVKSMSSLQNDRDRIVG 2478

Query: 261  FSTQREER-----LRKE--FEATTLRVRKLEENIEAERAAHLE------SKFNSEIIQLR 307
               Q EER     L K+   +       KL+E I   R+ H++      +K ++E+IQ R
Sbjct: 2479 DYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRS-HMDDLNSENAKLDAELIQYR 2537

Query: 308  IRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFS- 366
              DL   + ++ + Q +    LE+   + KE+E+ Y + +   +ES      L + + + 
Sbjct: 2538 -EDLNQVITIKDSQQKQL---LEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNAL 2593

Query: 367  --KNKKLNEDIEEQKKVIIDLSKRL------------------------------QYNEK 394
              + + L+++IE  K  I  L++++                                ++K
Sbjct: 2594 QEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQK 2653

Query: 395  SCSELQEELVMAKKHQAFLVETCENNVK-ELESILDSFTVSGQWTSGIHKDKDKPPSFSV 453
              +EL+EELV  +K  A  V   E+ +K EL+ +           +GI +++ +     V
Sbjct: 2654 RIAELEEELVCVQKEAAKKVGEIEDKLKKELKHL--------HHDAGIMRNETETAEERV 2705

Query: 454  VLERLRRTLTDYQNKLEDASNEEKACN--------ELDSTKQKIDSHTKNIKELQDKLAD 505
                L R L + + KL   + E K            + S +   D   + + EL+ K   
Sbjct: 2706 A--ELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDA 2763

Query: 506  VNKELSHLHTKCA---DREALISTLKVEL----QNVLHCWEKEKAQAAQSESELQKLSQA 558
              KEL+ L  +     +R+AL+S     +    +N L   EK   Q    + +L  LS  
Sbjct: 2764 SLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQ 2823

Query: 559  FHKDAEEKLTF------LHTLYQHLVAGCVLIKQPE------------GMLDKFSWSELC 600
                  +  +F      L     HL       ++ E               +  S  +  
Sbjct: 2824 LEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAM 2883

Query: 601  AVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDT--FTKVAEQIKAQES 658
            + LQ + D L+ +L    ++   +            +LQ+ Q+ T  F  + E+++ +  
Sbjct: 2884 SSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENL 2943

Query: 659  CWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLS 718
             W  +  +L ++ S   +  ++  +++        ++L+H++    +L   +S  + L  
Sbjct: 2944 SWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKV 3003

Query: 719  QTQRE 723
            Q QR+
Sbjct: 3004 QYQRQ 3008



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 232/1203 (19%), Positives = 476/1203 (39%), Gaps = 180/1203 (14%)

Query: 39   RKKLHWAKKEKLEITTKHNAE-----LASYESQIAKLR-SEVEKGEALRQ---SLEYDLA 89
            +K+L   K ++L +  K + E     +   + Q+ ++  S  EK   L +   SL  ++ 
Sbjct: 870  QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929

Query: 90   VARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFE 149
              +++  L  RA E +  +     E     +S L+   +E   A Q S+++ + E    +
Sbjct: 930  TLKEQLNLLSRAEEAKKEQVEEDNEV----SSGLKQNYDEMSPAGQISKEELQHEFDLLK 985

Query: 150  HDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQ 209
             + E+R   +Q        L++  SRLE+ L               +++++ + +E  L 
Sbjct: 986  KENEQRKRKLQAALINRKELLQRVSRLEEEL---------------ANLKDESKKEIPLS 1030

Query: 210  EEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERL 269
                E ER E++   + ++ + + +  K +++E         L++  SE E   Q    +
Sbjct: 1031 ----ETERGEVEEDKENKEYSEKCVTSKCQEIEI-------YLKQTISEKEVELQ---HI 1076

Query: 270  RKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQ--VEKASQAEAVA 327
            RK+ E       + +  ++       +     +++Q  I + +  +Q  +   + A    
Sbjct: 1077 RKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGD 1136

Query: 328  DLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSK 387
             + ++K             +H   E   K+  LEKE     KKL E +  +K ++    K
Sbjct: 1137 SVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAIL----K 1192

Query: 388  RLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKD- 446
            + Q  E+    L+EEL   K     L E  +   KE E+I D      Q    + +  D 
Sbjct: 1193 KAQEKER---HLREELKQQKDDYNRLQEQFDEQSKENENIGDQLR---QLQIQVRESIDG 1246

Query: 447  KPPSFSVVLERLRRTLTDYQNKLEDASNEEK---ACNELDSTKQKID--------SHTKN 495
            K PS            TD Q         E+      E   T+  ++        SH+++
Sbjct: 1247 KLPS------------TDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSED 1294

Query: 496  IKELQ--DKLADVNKELSHLHTKCADREALISTLKVEL----QNVLHCWEKEKAQAAQSE 549
               LQ    +A +  +L  +  +  + E  +S+   EL    + V    E+   Q  + E
Sbjct: 1295 ASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIE 1354

Query: 550  SELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDA 609
            S L+ +S      AE     L +  Q  +AG   +++ +  LD+    +L +  +E+V  
Sbjct: 1355 S-LKTVSHEAEVHAESLQQKLES-SQLQIAGLEHLRELQPKLDEL--QKLISKKEEDVSY 1410

Query: 610  LIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIK--AQESCWHRQKKEL 667
            L   L+     +  ++     + D ++ L    E    +  E+IK    E C  +QK E 
Sbjct: 1411 LSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEE 1470

Query: 668  ELQYSELFLEVQKRAQ----KFQEIAEKN---MEKLNHIEKSHEQLVLENSHFKKLLSQT 720
              + S    ++Q++ Q      +E  ++N    E+L+    + E+L    +  +  +S  
Sbjct: 1471 IGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQ 1530

Query: 721  QREQMSLLAACAL-----------MAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEI 769
             +E+ ++L   AL           M  +L    S S +  + +  L+      E    EI
Sbjct: 1531 NKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEI 1590

Query: 770  RTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFR---------KGVIAVLAANRLKILGQS 820
             +L  +      + QE+ K  +K ++ L++ +          + V+  +   + ++ G+ 
Sbjct: 1591 ESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKL 1650

Query: 821  CASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSM 880
             ++     E+ K          + Q+  +  +  KE++R        +    +  +    
Sbjct: 1651 RSTEANKKETEK----------QLQEAEQEMEEMKEKMRKFAK----SKQQKILELEEEN 1696

Query: 881  AELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLV-MECIPLHSSRSITYVEKDSL 939
              L+  +  A   ++ C   L+    +S A + +++  V ME   L         EKDSL
Sbjct: 1697 DRLRAEVHPAGDTAKECMETLL----SSNASMKEELERVKMEYETLSKKFQSLMSEKDSL 1752

Query: 940  ---VQRLAHGLH-KVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERR---- 991
               VQ L H +   V+  A       H   T  T    + I G T+   +  +  R    
Sbjct: 1753 SEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCS 1812

Query: 992  -----------------SLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEK 1034
                             S   E+  + + ++++K+ +   +  + +  EF Q+  + +EK
Sbjct: 1813 ESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQT--LENEK 1870

Query: 1035 ----FESACEELNNALLREEQAQM-LLNEQAQQLQELNYKLELHSSEE------------ 1077
                 + + ++    +L+EE  +M LLN+Q Q+      KL+  + EE            
Sbjct: 1871 NTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQL 1930

Query: 1078 ADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAA 1137
            A+ N ++G   + +++A+++    +  ++ L + +++LE++K++L +     ES +R   
Sbjct: 1931 AELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEY 1990

Query: 1138 KDK 1140
             +K
Sbjct: 1991 LEK 1993



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 68/328 (20%), Positives = 128/328 (39%), Gaps = 50/328 (15%)

Query: 965  ITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEF 1024
            I +    LQ++     +   AA+ + + L+L       S+N+  +E+    G  +     
Sbjct: 68   IRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQ 127

Query: 1025 KQSKLITHEKF----ESACEELNNALLREE------QAQML-------------LNEQAQ 1061
             + +L  H+K     E   E++ + L  +E      QAQ+              + E   
Sbjct: 128  SEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVM 187

Query: 1062 QLQELNYKLELHSSEEADKNQTLGE----AVKSLSEAKME--LRRKDQSLRQLNRHL--- 1112
              Q+L  K E  S+ +A  +QT  E     V    +A+ E  +R  +  L QL       
Sbjct: 188  MKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVE 247

Query: 1113 TQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASRND 1172
            T+++Q  R L+  + + E +L   A+  + +   + A E     +  Q+    +  +   
Sbjct: 248  TEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLR 307

Query: 1173 FTLQL----PKLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQLA-------STRIMTLE 1221
             T++      K+ LE   +E  +        Q  +   ++ ++ A        +R   LE
Sbjct: 308  NTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALE 367

Query: 1222 K----EMTSHRSHIAALK---SELHTAC 1242
            +    EM    SHI +L+    EL +AC
Sbjct: 368  QKHKAEMEEKTSHILSLQKTGQELQSAC 395


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  110 bits (274), Expect = 1e-23
 Identities = 234/1218 (19%), Positives = 492/1218 (40%), Gaps = 217/1218 (17%)

Query: 41   KLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLE---YDLAVARKEAGL 97
            KL++  K  L+ + +   E+A+ + +  +++  +EK EA R+ LE     L   + +  L
Sbjct: 833  KLYFKIKPLLK-SAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQL 891

Query: 98   GRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQ----------KWKEECRR 147
              +A ++ L +A    ++L     +L+AK  E  +  +  ++          K ++EC  
Sbjct: 892  QVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSE 951

Query: 148  FEHDLEE--------------RDNMIQNCNRE-------YDLLMKEKSRLEKTLQEALEK 186
             + D+++               +N ++N   E          L KEK  L++  Q+AL+ 
Sbjct: 952  LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDD 1011

Query: 187  HQREKNEMESHIR-----ETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKL 241
             Q E++++ S  +     E  +++     EQ +  R +L+   ++ +  ++   + +  L
Sbjct: 1012 LQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1071

Query: 242  ETEHMDCSDLLRR-------QTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAH 294
            E + +   + L++       Q S++E       +L+K+ +    R+ +LEE +EAER A 
Sbjct: 1072 ENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTAR 1131

Query: 295  -----LESKFNSEI--IQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREK 347
                 L S  + E+  I  R+ +  GA  V+     +  A+ + ++ + +E    +E   
Sbjct: 1132 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHE--- 1188

Query: 348  HNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAK 407
                   A    L K++     +L E I+  ++V   L K     EKS  +L+ + V + 
Sbjct: 1189 -------ATAAALRKKHADSVAELGEQIDNLQRVKQKLEK-----EKSEFKLELDDVTSN 1236

Query: 408  KHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDY-- 465
              Q   +   + N++++   L+                D+   + V LE  +R+L D+  
Sbjct: 1237 MEQ---IIKAKANLEKVSRTLE----------------DQANEYRVKLEEAQRSLNDFTT 1277

Query: 466  -QNKLEDASN------EEKACNELDSTKQKIDSHTKNIKELQDKLADVNK---ELSH-LH 514
             + KL+  +       EEK       T+ K+ S+T+ +++L+ +L +  K    L+H L 
Sbjct: 1278 QRAKLQTENGELARQLEEKEALISQLTRGKL-SYTQQMEDLKRQLEEEGKAKNALAHALQ 1336

Query: 515  TKCADREAL------ISTLKVELQNVLHCWEKEKAQ--------AAQSESELQ----KLS 556
            +   D + L       +  K ELQ VL     E AQ        A Q   EL+    KL+
Sbjct: 1337 SARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1396

Query: 557  QAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNR 616
            Q   +DAEE +  ++       A C  +++ +              LQ  ++ L+ D+ R
Sbjct: 1397 QRL-QDAEEAVEAVN-------AKCSSLEKTKHR------------LQNEIEDLMVDVER 1436

Query: 617  ANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFL 676
            +N     L+   +N    + E +Q  E++           +S     +KE     +ELF 
Sbjct: 1437 SNAAAAALDKKQRNFDKILAEWKQKYEES-----------QSELESSQKEARSLSTELF- 1484

Query: 677  EVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAG 736
                   K +   E+++E L   ++ ++ L  E S   + L +  +    L      +  
Sbjct: 1485 -------KLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEV 1537

Query: 737  ALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKG 796
                L S   AL      L+ +       +LE   +   +     +K EE +  K+  + 
Sbjct: 1538 EKLELQS---ALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQR 1594

Query: 797  LIRIFRKGVIA-VLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQK 855
            ++   +  + A   + N +  + +        ME             +    ++     +
Sbjct: 1595 VVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEI------------QLSHANRMAAEAQ 1642

Query: 856  EQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKL-MD 914
            +Q++ LQ+L           +  +  +L D +     N  +  ++ I   +N+  +  ++
Sbjct: 1643 KQVKSLQSL-----------LKDTQIQLDDAV---RANDDLKENIAIVERRNNLLQAELE 1688

Query: 915  KISLVMECIPLHSSRSITYVEKDSL-VQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQ 973
            ++  V+E     + RS    E++ +        LH  NT  +    +    +T+    LQ
Sbjct: 1689 ELRAVVE----QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQ----LQ 1740

Query: 974  KQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHE 1033
             ++    Q    AE + +     +T+      E+KKE D +  L+              +
Sbjct: 1741 SEVEEAVQECRNAEEKAKK---AITDAAMMAEELKKEQDTSAHLERM-----------KK 1786

Query: 1034 KFESACEELNNALLREEQAQMLLNEQAQQLQELNYKL-ELHSSEEADKNQTLGEAVKSLS 1092
              E   ++L + L  +E  Q+ L    +QLQ+L  ++ EL    EA++ +   E+VK + 
Sbjct: 1787 NMEQTIKDLQHRL--DEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRN-AESVKGMR 1843

Query: 1093 EAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVEN 1152
            +++  ++       +  ++L +L+    +L+  +   +     A +      +  R V++
Sbjct: 1844 KSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQH 1903

Query: 1153 TLHKVRDQISLSWSAASR 1170
             L +  ++  ++ S  ++
Sbjct: 1904 ELDEAEERADIAESQVNK 1921



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 166/796 (20%), Positives = 325/796 (40%), Gaps = 117/796 (14%)

Query: 36   DNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEA 95
            DNL++     +KEK E   + + ++ S   QI K ++ +EK     +    +  V  +EA
Sbjct: 1210 DNLQRVKQKLEKEKSEFKLELD-DVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEA 1268

Query: 96   GLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEER 155
                     + A+      +L  Q  E +A  ++  +   +  Q+ ++  R+ E + + +
Sbjct: 1269 QRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAK 1328

Query: 156  DNM---IQNCNREYDLLMK---EKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQ 209
            + +   +Q+   + DLL +   E++  +  LQ  L K   E  +  +     A++    +
Sbjct: 1329 NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQ----R 1384

Query: 210  EEQWEAERRELQFIVQEQDTAVQNMHKKVEKLE-TEHMDCSDLLRRQTSELEFSTQREER 268
             E+ E  +++L   +Q+ + AV+ ++ K   LE T+H        R  +E+E      ER
Sbjct: 1385 TEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKH--------RLQNEIEDLMVDVER 1436

Query: 269  LRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVAD 328
                  A   + R  ++ +   +  + ES+   E  Q   R L   L   K +  E++  
Sbjct: 1437 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1496

Query: 329  LEIIKNEFKEVESAYE----------REKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQ 378
            LE  K E K ++              +  H  ++   +L + + E  S  ++    +E +
Sbjct: 1497 LETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHE 1556

Query: 379  KKVIIDLSKRLQYN------EKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFT 432
            +  I  L  +L++N      E+  +E  EE+  AK++   +V++       L++ LD+ T
Sbjct: 1557 EGKI--LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDS-------LQTSLDAET 1607

Query: 433  VSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSH 492
                                    R R  +   + K+E   NE +   +L    +     
Sbjct: 1608 ------------------------RSRNEVLRVKKKMEGDLNEMEI--QLSHANRMAAEA 1641

Query: 493  TKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESE- 551
             K +K LQ  L D   +L        D +  I+   VE +N L   E E+ +A   ++E 
Sbjct: 1642 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI--VERRNNLLQAELEELRAVVEQTER 1699

Query: 552  LQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDA-- 609
             +KL++    +  E++  LH+    L+      K+ E  L +   SE+   +QE  +A  
Sbjct: 1700 SRKLAEQELIETSERVQLLHSQNTSLIN---QKKKMESDLTQLQ-SEVEEAVQECRNAEE 1755

Query: 610  -----------LIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQES 658
                       +  +L +  +   HLE + KN   T+++LQ   ++     AEQI  +  
Sbjct: 1756 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE-----AEQIALKGG 1810

Query: 659  CWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLS 718
                QK E  ++  E  LE +++         +N E +  + KS  ++       K+L  
Sbjct: 1811 KKQLQKLEARVRELEGELEAEQK---------RNAESVKGMRKSERRI-------KELTY 1854

Query: 719  QTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNT-FELFKLEIRTLAQALS 777
            QT+ ++ +LL     +   +  L  +  A   Q +  +EQ NT    F+     L +A  
Sbjct: 1855 QTEEDKKNLLR----LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEE 1910

Query: 778  TVEEKKQEEAKMKKKT 793
              +  + +  K++ K+
Sbjct: 1911 RADIAESQVNKLRAKS 1926



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 95/415 (22%), Positives = 178/415 (42%), Gaps = 66/415 (15%)

Query: 33   DITDNLR---KKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLA 89
            D+T+ L    K +H  +K + ++  +     ++ E   A L  E E+G+ LR  LE++  
Sbjct: 1513 DLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASL--EHEEGKILRAQLEFNQI 1570

Query: 90   VARKEAGLGRRAAEERLAEAHRIQEKLC-AQNSELQAKTNETEKAFQTSQQKWKEECRRF 148
             A  E  L  +  +E + +A R  +++  +  + L A+T    +  +          ++ 
Sbjct: 1571 KAEIERKLAEK--DEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVK--------KKM 1620

Query: 149  EHDLEERDNMIQNCNR---EYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIR------ 199
            E DL E +  + + NR   E    +K    L K  Q  L+   R  ++++ +I       
Sbjct: 1621 EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRN 1680

Query: 200  ---ETALEEFRLQEEQWEAERR----------ELQFIVQEQDTAVQNMHKKVE------- 239
               +  LEE R   EQ E  R+          E   ++  Q+T++ N  KK+E       
Sbjct: 1681 NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQ 1740

Query: 240  -KLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIE---------- 288
             ++E    +C +   +    +  +    E L+KE + T+  + ++++N+E          
Sbjct: 1741 SEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE-QDTSAHLERMKKNMEQTIKDLQHRL 1799

Query: 289  --AERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYERE 346
              AE+ A    K   + ++ R+R+LEG L+ E+   AE+V  +   +   KE+    E +
Sbjct: 1800 DEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEED 1859

Query: 347  KHN---AQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSE 398
            K N    Q+   KL L  K Y    K+  E+ EEQ    +   +++Q+      E
Sbjct: 1860 KKNLLRLQDLVDKLQLKVKAY----KRQAEEAEEQANTNLSKFRKVQHELDEAEE 1910



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 180/903 (19%), Positives = 360/903 (39%), Gaps = 158/903 (17%)

Query: 332  IKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVII----DLSK 387
            IK   K  E+  E+E    +E F ++    KE   K++   +++EE+   ++    DL  
Sbjct: 838  IKPLLKSAET--EKEMATMKEEFGRI----KETLEKSEARRKELEEKMVSLLQEKNDLQL 891

Query: 388  RLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKEL-ESILDSFTVSGQWTSGIHKDKD 446
            ++Q  + + ++ +E      K++  L    E  VKE+ E + D   ++ + T+   K +D
Sbjct: 892  QVQAEQDNLNDAEERCDQLIKNKIQL----EAKVKEMNERLEDEEEMNAELTAKKRKLED 947

Query: 447  KPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADV 506
            +          L++ + D +  L     E+ A      T+ K+ + T+ +  L + +A +
Sbjct: 948  E-------CSELKKDIDDLELTLAKVEKEKHA------TENKVKNLTEEMAGLDEIIAKL 994

Query: 507  NKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEK 566
             KE   L    A ++AL   L+VE ++ ++   K K +  Q   +L+        + E+K
Sbjct: 995  TKEKKALQE--AHQQAL-DDLQVE-EDKVNSLSKSKVKLEQQVDDLEG-----SLEQEKK 1045

Query: 567  LTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEY 626
            +       +  + G + + Q E ++D  +       L+E +     D+N+ N KI   + 
Sbjct: 1046 VRMDLERAKRKLEGDLKLTQ-ESIMDLENDK---LQLEEKLKKKEFDINQQNSKIEDEQV 1101

Query: 627  ICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQ 686
            +       ++E Q   E+    + E+++A+ +     + ++E   S+L  E+++ +++ +
Sbjct: 1102 LALQLQKKLKENQARIEE----LEEELEAERTA----RAKVEKLRSDLSRELEEISERLE 1153

Query: 687  EIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSC 746
            E       ++   +K         + F+K+    +   +   A  A    AL   ++ S 
Sbjct: 1154 EAGGATSVQIEMNKK-------REAEFQKMRRDLEEATLQHEATAA----ALRKKHADSV 1202

Query: 747  A-LSTQRDFLQEQVNTFELFKLEIRT-LAQALSTVEEKKQEEAKMKK--KTFKGLIRIFR 802
            A L  Q D LQ      E  K E +  L    S +E+  + +A ++K  +T +     +R
Sbjct: 1203 AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYR 1262

Query: 803  KGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQ 862
                      +L+   +S     T     +   G L    E          +KE L    
Sbjct: 1263 V---------KLEEAQRSLNDFTTQRAKLQTENGELARQLE----------EKEAL---- 1299

Query: 863  ALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMEC 922
             +S LT   L     S   +++D+  + +           G AKN+ A  +   S   +C
Sbjct: 1300 -ISQLTRGKL-----SYTQQMEDLKRQLEEE---------GKAKNALAHALQ--SARHDC 1342

Query: 923  IPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQR 982
              L       Y E+      L   L K N+   ++  +      + T  L++      QR
Sbjct: 1343 DLLREQ----YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1398

Query: 983  LHAAEVERRSLRLEVTEFKRSVNEMKKELDK-----------AQGLQMQLNEFKQSKLIT 1031
            L  AE    ++  + +  +++ + ++ E++            A  L  +   F +     
Sbjct: 1399 LQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEW 1458

Query: 1032 HEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSL 1091
             +K+E +  EL ++   +++A+ L  E  +        LE H      +N+ L E +  L
Sbjct: 1459 KQKYEESQSELESS---QKEARSLSTELFKLKNAYEESLE-HLETFKRENKNLQEEISDL 1514

Query: 1092 SEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESAL------------------ 1133
            +E   +L    +++ +L +   QLE +K  L+  + +AE++L                  
Sbjct: 1515 TE---QLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIK 1571

Query: 1134 -----RMAAKDKE---CVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLETF 1185
                 ++A KD+E      NH R V++       Q SL     SRN+      K+  +  
Sbjct: 1572 AEIERKLAEKDEEMEQAKRNHQRVVDSL------QTSLDAETRSRNEVLRVKKKMEGDLN 1625

Query: 1186 AME 1188
             ME
Sbjct: 1626 EME 1628



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 67/305 (21%), Positives = 127/305 (41%), Gaps = 33/305 (10%)

Query: 987  EVERRSLRLEVTEFKRS--VNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNN 1044
            ++E   L+LE    K+   +N+   +++  Q L +QL +  +      E+ E   E    
Sbjct: 1070 DLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERT 1129

Query: 1045 ALLREEQAQMLLNEQAQQLQE--------LNYKLELHSSEEAD---KNQTLGEAVKSLSE 1093
            A  + E+ +  L+ + +++ E         + ++E++   EA+     + L EA      
Sbjct: 1130 ARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEA 1189

Query: 1094 AKMELRRKD-QSLRQLNRHLTQLEQDKRRLEE-------NIHDAESALRMAAKDKECVAN 1145
                LR+K   S+ +L   +  L++ K++LE+        + D  S +    K K  +  
Sbjct: 1190 TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEK 1249

Query: 1146 HMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGPEVVACQAMIKS 1205
              R +E+  ++ R  + L  +  S NDFT Q  KL  E   +       E +  Q + + 
Sbjct: 1250 VSRTLEDQANEYR--VKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQ-LTRG 1306

Query: 1206 FMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTA-CLRE--------NASLQSIGSRD 1256
             +   Q        LE+E  +  +   AL+S  H    LRE         A LQ + S+ 
Sbjct: 1307 KLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKA 1366

Query: 1257 HSNLS 1261
            +S ++
Sbjct: 1367 NSEVA 1371


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  107 bits (268), Expect = 6e-23
 Identities = 195/867 (22%), Positives = 345/867 (39%), Gaps = 145/867 (16%)

Query: 20   LDVKQILKNETELDITDNLRKKLHWAKKEKLEITTK-HNAELASYESQIAKLRSEVEKGE 78
            L+ K +L  E +L+ T     KLH  +KE L++  K H+ E+   +    K+   +E+  
Sbjct: 357  LETKTML--EDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER-DMDRKKIEELMEENM 413

Query: 79   AL----RQSLEYDLAVARKEAGLGRRAAEERLAEA------HRIQE-------KLCAQNS 121
             L    +QS++  L +  +   + R +    L+EA      H + E       KL  +N 
Sbjct: 414  TLEMAQKQSMDESLHLGWELEQISRTS---ELSEAPQKSLGHEVNELTSSRLLKLEMENQ 470

Query: 122  ELQAKTNETEKA-------------FQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDL 168
             L     E                  +   Q+  ++    E+++ +    +QNC      
Sbjct: 471  SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKD 530

Query: 169  LMKEKSRLEKTLQ----------EALEKHQREKNEMESHIRETALEEFRLQEEQWEAERR 218
            LMKEK++LEKT++          + LE+     N+  S +R+ +      + +  E E +
Sbjct: 531  LMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590

Query: 219  ELQFIVQEQDTAVQNMH-----------------KKVEKLETE--HMDC-SDLLRRQTSE 258
             L   ++E  + +  +                  ++ E+LE E  H++  ++LL+++ + 
Sbjct: 591  ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650

Query: 259  LEFSTQREERLRKEFEATTLRVRKLEENIEAER--AAHLESKFNSEIIQLRIRDLEGALQ 316
            L+ + ++ E L +E        RKL++ +++ +     LES    E  QL   +LE    
Sbjct: 651  LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES-LEKENSQLDEENLELRRN 709

Query: 317  VEKASQAE-AVADLEIIKNEFKEVESAYEREKHNAQ---ESFAKLNLLEKEYFS---KNK 369
            VE    A   +A L++   E KE+ES  E+ K   +    SF K   LE  Y     +N+
Sbjct: 710  VESLKCASMKMAQLQL---ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766

Query: 370  KLNEDIEEQKKVIIDLSKRLQYNEKSCSELQ---EELVMAKKHQAFLVETCENNVKELES 426
            +L + +E   K I  L   LQ  E     LQ   EEL ++ K     +E  E   K LE 
Sbjct: 767  RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR----LEQLEKENKSLE- 821

Query: 427  ILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEK--ACNELDS 484
                     Q TS + KDK +       LE+  + L   Q +++D + EE       L+ 
Sbjct: 822  ---------QETSQLEKDKKQ-------LEKENKRLRQ-QAEIKDTTLEENNVKIGNLEK 864

Query: 485  TKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQ 544
              + +       KE   +L ++ KE   L  +       + TL+ +L +       EK +
Sbjct: 865  ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS-------EKLK 917

Query: 545  AAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQ 604
              Q  ++L+KL+    K    K   LH          +L  + E  L K        + +
Sbjct: 918  TQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKK-----SLEIKE 972

Query: 605  ENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQ-EDTFTKVAEQIKAQESCWHRQ 663
            E + AL A L  +    + L    K        L+Q Q E+   + +  I  +++ W R+
Sbjct: 973  EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1032

Query: 664  KKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQRE 723
             +E   +     L+V+              ++L  +E+++  L  E    K  L Q + +
Sbjct: 1033 SQETTRE----LLKVK--------------DRLIEVERNNATLQAEKQALKTQLKQLETQ 1074

Query: 724  QMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTF-----ELFKLEIRTLAQALST 778
              +L A    +      L  ++  L TQ   LQ + +T       L     + L Q  S 
Sbjct: 1075 NNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSL 1134

Query: 779  VEEKKQ--EEAKMKKKTFKGLIRIFRK 803
              E +   +E +  K  +  LI+   K
Sbjct: 1135 ENENESVIKEREDLKSLYDSLIKDHEK 1161



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 217/1079 (20%), Positives = 421/1079 (39%), Gaps = 197/1079 (18%)

Query: 126  KTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALE 185
            K  E+ +         K + RR   +LEE+   + +C +E + +  E  RL++     L 
Sbjct: 241  KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300

Query: 186  --KHQREKNEMESHIRETALEEFRLQEE--QWEAERRELQFIVQEQDTAVQNMHKKVEKL 241
              +  R   +    +RE A+   +L+ E  +++    +++F              +VE+L
Sbjct: 301  DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEF-----------YKARVEEL 349

Query: 242  ETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNS 301
            + ++    +       +LE +  R ++L  E E   L+++    ++E ER   ++ K   
Sbjct: 350  KEDNQVLLETKTMLEDQLEGTRARSDKLH-ELEKENLQLKAKLHDMEMER--DMDRKKIE 406

Query: 302  EIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQE-SFAKLNLL 360
            E+++  +  LE A +           +LE I    +  E+  +   H   E + ++L  L
Sbjct: 407  ELMEENM-TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL 465

Query: 361  EKEYFSKNKKLNE------DIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLV 414
            E E  S  K + E       +E     I+ + K  Q   K    L+ E+V  K+     +
Sbjct: 466  EMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS----L 521

Query: 415  ETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASN 474
            + C+N  K+L                  K+K         +E LR   ++ Q K+ +  N
Sbjct: 522  QNCQNLSKDL-----------------MKEK---AQLEKTIETLREN-SERQIKILEQEN 560

Query: 475  EEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNV 534
            E      L+ T   +   ++   E + K  D+ KE   LH    +  + +S ++ E + +
Sbjct: 561  E-----HLNQTVSSLRQRSQISAEARVK--DIEKENKILHESIKETSSKLSKIEFEKRQI 613

Query: 535  ---LHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGML 591
               L  ++++  +A + E+EL  L +  ++  ++K+T L                     
Sbjct: 614  KKELEHYKEKGERAEELENELHHLEKE-NELLQKKITNL--------------------- 651

Query: 592  DKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAE 651
             K +  ++ A+ QEN     ++L R N K++      KN +  +  L++       +  E
Sbjct: 652  -KITCEKIEALEQEN-----SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705

Query: 652  QIKAQES--CWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLE 709
              +  ES  C   +  +L+L+  EL  E +++ +K  E+ + + +K   +E S++ L +E
Sbjct: 706  LRRNVESLKCASMKMAQLQLENKELESE-KEQLKKGLELLKASFKKTERLEVSYQGLDIE 764

Query: 710  NSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEI 769
            N   +K L  + ++              +  L S    L  +   LQ+ +   ++    +
Sbjct: 765  NQRLQKTLENSNKK--------------IQQLESELQDLEMENQTLQKNLEELKISSKRL 810

Query: 770  RTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVI--AVLAANRLKI--LGQSCASLF 825
              L +   ++E++  +  K KK+  K   R+ ++  I    L  N +KI  L +   +L 
Sbjct: 811  EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLS 870

Query: 826  TWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQD 885
              +  +KE    L          +  K  KE ++    +   T   L   ++S   + Q 
Sbjct: 871  KEIGIYKESCVRL---------KELEKENKELVK-RATIDIKTLVTLREDLVSEKLKTQQ 920

Query: 886  VIGKADPNSRICGHLLIGAAKNSFAKL---MDKISLVMECIPLHSSRSITYVEKDSLVQR 942
            +                    N   KL   ++KI L  E + LH  +S T      L  +
Sbjct: 921  M-------------------NNDLEKLTHELEKIGLNKERL-LHDEQS-TDDRYKLLESK 959

Query: 943  LAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKR 1002
            L   L K  +L +K                +++I     RL  +    + LR E+   K+
Sbjct: 960  LESTLKK--SLEIK----------------EEKIAALEARLEESTNYNQQLRQELKTVKK 1001

Query: 1003 SVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACE-----------ELNNALLREE- 1050
            +   +K+  D+ + +Q       +      E  E+  E           E NNA L+ E 
Sbjct: 1002 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061

Query: 1051 -----------------QAQML-LNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLS 1092
                             QAQ+L L  Q   LQE N  L+  +++   +N TL     SL 
Sbjct: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121

Query: 1093 EAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENI---HDAESAL--RMAAKDKECVANH 1146
                +L  +  SL   N  + +  +D + L +++   H+    L  R A++ +  ++ H
Sbjct: 1122 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKH 1180



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 103/513 (20%), Positives = 219/513 (42%), Gaps = 44/513 (8%)

Query: 12   TQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLR 71
            T  L+   L+ +++L +E     TD+  K L    + KLE T K + E+   E +IA L 
Sbjct: 929  THELEKIGLNKERLLHDEQS---TDDRYKLL----ESKLESTLKKSLEIK--EEKIAALE 979

Query: 72   SEVEKGEALRQSLEYDLAVARKE-AGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNET 130
            + +E+     Q L  +L   +K    L +R  EER+ ++          +  +  + N+ 
Sbjct: 980  ARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS----------SPPISGEDNKW 1029

Query: 131  EKAFQ-TSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQR 189
            E+  Q T+++  K + R  E  +E  +  +Q   +     +K+       LQ  +   QR
Sbjct: 1030 ERESQETTRELLKVKDRLIE--VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR 1087

Query: 190  EKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQE-----QDTAVQNMHKKVEKLETE 244
            +   ++        +  +LQ E      +    + Q      Q ++++N ++ V K   +
Sbjct: 1088 QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERED 1147

Query: 245  HMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEII 304
                 D L +   +LE   +R+    +   +    ++   +N+E E    LE ++N  + 
Sbjct: 1148 LKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR-DLEDRYNQLLK 1206

Query: 305  QL-RIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKE 363
            Q  ++ DLE  L+VE+        + E +  E+K++    +R  H   +   +  +L+ +
Sbjct: 1207 QKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD 1266

Query: 364  YFSKNKKLNEDIEEQKKVIIDLSK-RLQYNEKSCSELQEELVMAKKHQAFLVETCENNV- 421
            + +    LN    EQ ++  + SK + QY +   +  +        +Q  L+   + N+ 
Sbjct: 1267 HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTK------LNNQCELLSQLKGNLE 1320

Query: 422  KELESILDSF-TVSGQWTSGIHKDKDKPPSFSV----VLERLRRTLTDYQNKLEDASNEE 476
            +E   +LD   T+  Q  + + ++ +    F V     +++L   L   + KLE+   ++
Sbjct: 1321 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNE-LRRQKEKLEEKIMDQ 1379

Query: 477  KACNELDSTKQKIDSHTKNIKELQDKLADVNKE 509
                +    +++ +  T  +++L     D+N+E
Sbjct: 1380 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRE 1412



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 138/670 (20%), Positives = 259/670 (38%), Gaps = 88/670 (13%)

Query: 512  HLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLH 571
            HL  + AD +A I  L+ EL+         K +  Q E EL++L Q       E +  L 
Sbjct: 248  HLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ-------ENMNLLS 300

Query: 572  TLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQE--NVDALIADLNRANEKIRHLEYICK 629
                            +    +    EL A+ ++   VD L ++++R  E++  +E+  K
Sbjct: 301  ----------------DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFY-K 343

Query: 630  NKSDTMRELQQTQEDTFTKVAEQI---KAQESCWHRQKKE---LELQYSELFLEVQKRAQ 683
             + + ++E  Q   +T T + +Q+   +A+    H  +KE   L+ +  ++ +E     +
Sbjct: 344  ARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRK 403

Query: 684  KFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYS 743
            K +E+ E+NM     +E + +Q + E+ H    L Q  R      A    +   +  L S
Sbjct: 404  KIEELMEENMT----LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTS 459

Query: 744  -RSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFR 802
             R   L  +    Q    T E  +  + ++    S + + ++E  ++ KK       I +
Sbjct: 460  SRLLKLEMEN---QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ 516

Query: 803  KGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQ 862
            +        N  K L +  A L   +E+ +E     +   E +++H              
Sbjct: 517  EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEH-------------- 562

Query: 863  ALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMEC 922
             L+   SS    + IS+ A ++D+  +          +L  + K + +KL  KI      
Sbjct: 563  -LNQTVSSLRQRSQISAEARVKDIEKE--------NKILHESIKETSSKL-SKIEFEKRQ 612

Query: 923  IPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTA------------ 970
            I           E+   ++   H L K N L  K      +   K  A            
Sbjct: 613  IKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELEREN 672

Query: 971  -SLQKQILGF---TQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQ 1026
              L+K +  F   T +L + E E   L  E  E +R+V  +K    K   LQ++  E + 
Sbjct: 673  RKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELES 732

Query: 1027 SKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGE 1086
             K    E+ +   E L  +  + E+ ++      Q L   N +L+        K Q L  
Sbjct: 733  EK----EQLKKGLELLKASFKKTERLEV----SYQGLDIENQRLQKTLENSNKKIQQLES 784

Query: 1087 AVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANH 1146
             ++ L      L++  + L+  ++ L QLE++ + LE+     E   +   K+ + +   
Sbjct: 785  ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844

Query: 1147 MRAVENTLHK 1156
                + TL +
Sbjct: 845  AEIKDTTLEE 854



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 73/337 (21%), Positives = 143/337 (42%), Gaps = 38/337 (11%)

Query: 3    LNTSSNTGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELAS 62
            LN+ S +   Q  ++         +NE+ +   ++L+       K+  ++   H  + + 
Sbjct: 1113 LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1172

Query: 63   YESQIAK---LRSEVEKGEALRQSLE--YDLAVARKEAGLGRRAAEERLAEAHRIQEKLC 117
            YES I+K   L+S  +  E   + LE  Y+  + +K    G+    E++ +    QEK+ 
Sbjct: 1173 YESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK----GQLEDLEKMLKVE--QEKML 1226

Query: 118  AQN-------SELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLM 170
             +N       +E +    E ++   T  Q  K E    + D +   +++ N   E   L 
Sbjct: 1227 LENKNHETVAAEYKKLCGENDRLNHTYSQLLK-ETEVLQTDHKNLKSLLNNSKLEQTRLE 1285

Query: 171  KEKSRLEKTLQEALEKHQREKNEME--SHIRETALEEFRLQEEQWEAERRELQFIVQEQD 228
             E S+L++  Q+      +  N+ E  S ++    EE R   +Q +        ++Q + 
Sbjct: 1286 AEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQT------LMLQNRT 1339

Query: 229  TAVQNMHKK--VEKLETEHMDCSDLLRRQTSELEFSTQREERL------RKEFEATTLRV 280
               QNM  K      + +++D  + LRRQ  +LE     + +       R+     TL++
Sbjct: 1340 LLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKM 1399

Query: 281  RKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQV 317
            RKL   I++++  + E + +  +   R    EG LQ+
Sbjct: 1400 RKL---IKSKKDINRERQKSLTLTPTRSDSSEGFLQL 1433



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 73/328 (22%), Positives = 134/328 (40%), Gaps = 49/328 (14%)

Query: 990  RRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLRE 1049
            R+ L +E+ + K  +  +++EL++      QL + KQ       + +   +E  N L   
Sbjct: 246  RQHLSVELADAKAKIRRLRQELEEKTE---QLLDCKQELEQMEIELKRLQQENMNLLSDA 302

Query: 1050 EQAQML------LNEQAQQLQELN-----YKLELHSSE-EADKNQTLGEAVKSLSEAKME 1097
              A+M       L E+A ++ +L      YK  LH  E    + + L E  + L E K  
Sbjct: 303  RSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM 362

Query: 1098 LRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKV 1157
            L  + +  R  +  L +LE++  +L+  +HD E    M  K  E +      +E    + 
Sbjct: 363  LEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQS 422

Query: 1158 RDQ-ISLSW--SAASRNDFTLQLPKLHL-----ETFAMEGLK---GGPEVVACQAMIKSF 1206
             D+ + L W     SR     + P+  L     E  +   LK       +      +++ 
Sbjct: 423  MDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTT 482

Query: 1207 MDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTACLRENASLQSIGSRDHSNLSIPSRA 1266
            +D  +  +++I+ +EKE       +  L++E+    ++E  SLQ+       NLS     
Sbjct: 483  VDSVEGNASKILKMEKENQRLSKKVEILENEI----VQEKQSLQNC-----QNLS----- 528

Query: 1267 PLPADTTGIGDFLPLKAELDTTYTFLKE 1294
                      D +  KA+L+ T   L+E
Sbjct: 529  ---------KDLMKEKAQLEKTIETLRE 547



 Score = 39.7 bits (91), Expect = 0.019
 Identities = 55/251 (21%), Positives = 109/251 (43%), Gaps = 39/251 (15%)

Query: 972  LQKQILGFTQRLHAAEVERRSLRLEVTEF-----------KRSVNEM------------K 1008
            L+K+ L    +LH  E+ER   R ++ E            K+S++E              
Sbjct: 380  LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT 439

Query: 1009 KELDKA--QGLQMQLNEFKQSKLIT----HEKFESACEELNNALLREEQAQMLLNEQAQQ 1062
             EL +A  + L  ++NE   S+L+     ++      EEL   +   E     + +  ++
Sbjct: 440  SELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKE 499

Query: 1063 LQELNYKLELHSSEEADKNQTLGEAV---KSLSEAKMELRRKDQSLRQLN-RHLTQLEQD 1118
             Q L+ K+E+  +E   + Q+L       K L + K +L +  ++LR+ + R +  LEQ+
Sbjct: 500  NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQE 559

Query: 1119 KRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLP 1178
                 E+++   S+LR   + +      ++ +E     + + I  + S  S+ +F  +  
Sbjct: 560  N----EHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613

Query: 1179 KLHLETFAMEG 1189
            K  LE +  +G
Sbjct: 614  KKELEHYKEKG 624



 Score = 38.5 bits (88), Expect = 0.043
 Identities = 36/157 (22%), Positives = 63/157 (40%), Gaps = 1/157 (0%)

Query: 973  QKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITH 1032
            Q+++L   +       E + L  E      + +++ KE +  Q     L     +  +  
Sbjct: 1222 QEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQ 1281

Query: 1033 EKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLS 1092
             + E+   +L     + +     LN Q + L +L   LE  +    D+ QTL    ++L 
Sbjct: 1282 TRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLL 1341

Query: 1093 EAKMELRRK-DQSLRQLNRHLTQLEQDKRRLEENIHD 1128
            E  ME +       RQ    L +L + K +LEE I D
Sbjct: 1342 EQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1378


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  107 bits (266), Expect = 1e-22
 Identities = 231/1209 (19%), Positives = 473/1209 (39%), Gaps = 156/1209 (12%)

Query: 40   KKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGR 99
            K L    +++ E+  K + EL   + +  K+  E+E+ E   Q L  +  +  ++     
Sbjct: 842  KPLLQVTRQEEELQAK-DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQL---- 896

Query: 100  RAAEERLAEAHRIQEKLCAQNSELQ----------AKTNETEKAFQTSQQKWKEECRRFE 149
            +A  E  AEA  ++ +L A+  EL+           +  E  +  Q  ++K +   +  E
Sbjct: 897  QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE 956

Query: 150  HDLEERDNMIQNCNREYDLLMKEKSRLEK---TLQEALEKHQREKNEMESHIRETALEEF 206
              L+E +   Q    E      +  ++E+    L++   K  +EK  ME  I E + +  
Sbjct: 957  EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQ-- 1014

Query: 207  RLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQRE 266
             L EE  E + + L  I  +Q+  + ++ ++++K E    +     R+   E      + 
Sbjct: 1015 -LAEE--EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071

Query: 267  ERLRKEFEATTLRVRKLEENIEAERAAHLESKFNS-------EIIQLRIRDLEGALQVEK 319
              L+ + +   L++ K EE ++   A   +   +          +Q +I +L+   + EK
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131

Query: 320  ASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQK 379
            AS+ +A      +  E + +++  E                E+E     K L E+ +  +
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191

Query: 380  KVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTS 439
              I D+ +R   +  +  EL E+L  AK+ +A L    E N + LE+             
Sbjct: 1192 AQIQDMRQR---HATALEELSEQLEQAKRFKANL----EKNKQGLET------------- 1231

Query: 440  GIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKEL 499
                  +K  +  V + +  +  ++++ K  DA  +E      +  + +++   K  K L
Sbjct: 1232 -----DNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASK-L 1285

Query: 500  QDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQ-- 557
            Q++L +V+  L     K        ++L+ +LQ+     ++E  Q     S +++L +  
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345

Query: 558  -AFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAV--LQENVDALIADL 614
             +  +  EE+      L + ++A    +   +  +D     +L  +  L+E    L+ D 
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVD----DDLGTIESLEEAKKKLLKDA 1401

Query: 615  NRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSEL 674
               ++++            T   LQQ  +D    +  Q +   +   +QKK  +L   E 
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEK 1461

Query: 675  FLE---VQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAAC 731
             +     ++R +   E  EK  + L+ + ++ E+ +     F++   Q + +   L+++ 
Sbjct: 1462 SISARYAEERDRAEAEAREKETKALS-LARALEEALEAKEEFERQNKQLRADMEDLMSSK 1520

Query: 732  ALMAGALYPLYSRSCALS-------TQRDFLQEQVNTFELFKLEIRTLAQALSTVEEK-- 782
              +   ++ L     AL        TQ + L++++   E  KL +    QA+    E+  
Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL 1580

Query: 783  --KQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVC 840
              + E+ + KK+     +R     +        L +  +            K  I +   
Sbjct: 1581 QTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKK-----------KMEIDLKDL 1629

Query: 841  TGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHL 900
              + +  +K      +QLR LQA                M + Q  + +A    R     
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQA---------------QMKDYQRELEEA----RASRDE 1670

Query: 901  LIGAAKNSFAKL----MDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALK 956
            +   +K S  KL     + + L  E      +R     E+D L   + +           
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN----------- 1719

Query: 957  YGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRS---VNEMKKELDK 1013
                G   +      L+ +I    + L   E E+ ++ L    F+++   V+ +  EL  
Sbjct: 1720 -SASGKSALLDEKRRLEARIAQLEEEL---EEEQSNMELLNDRFRKTTLQVDTLNAELAA 1775

Query: 1014 AQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELH 1073
             +    + +  +Q     +++ ++  +EL  A+  + +A +   E   ++ +L  +LE  
Sbjct: 1776 ERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE--AKIGQLEEQLEQE 1833

Query: 1074 SSEEADKNQTLGEAVKSLSEAKM----ELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDA 1129
            + E A  N+ +    K L E  M    E R  DQ   Q+ +   +++Q KR+LEE   +A
Sbjct: 1834 AKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEA 1893

Query: 1130 ESA----------LRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLPK 1179
              A          L  A +  E ++  +  ++N L +    IS S S + R        +
Sbjct: 1894 TRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR-GGPISFSSSRSGRR-------Q 1945

Query: 1180 LHLETFAME 1188
            LHLE  ++E
Sbjct: 1946 LHLEGASLE 1954



 Score =  107 bits (266), Expect = 1e-22
 Identities = 188/854 (22%), Positives = 361/854 (42%), Gaps = 104/854 (12%)

Query: 26   LKNETELDITDNLRKKLHWAKKEKLEITT---KHNAELASYESQIAKLRSEVEKGEALRQ 82
            ++N+ E+ I+D L ++L   +K + E+     K + E    + QIA+L+++++       
Sbjct: 1028 IRNKQEVMISD-LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID------- 1079

Query: 83   SLEYDLAVARKEA---GLGRRAAEERLAE--AHRIQEKLCAQNSELQAKTNETEKAFQTS 137
              E  L +A+KE    G   R  +E L +  A ++  +L AQ +ELQ +  E+EKA +  
Sbjct: 1080 --ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQ-EDFESEKASRNK 1136

Query: 138  QQKWKEECRRFEHDLE-ERDNMIQNCNREYDLLMK---EKSRLEKTLQEALEKHQREKNE 193
             +K K +       L+ E ++ +     + +L  K   E + L+K L+E  + H+ +  +
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQD 1196

Query: 194  MESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVE-----KLETEHMDC 248
            M      TALEE   Q EQ +  +  L+   Q  +T  + +  +V+     K E+EH   
Sbjct: 1197 MRQR-HATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHK-- 1253

Query: 249  SDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEA--ERAAHLESKFNSEIIQL 306
               L  Q  EL       +RLR E      +++   +N+    E A     KF  +   L
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASL 1313

Query: 307  --RIRDLEGALQVE---KASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLE 361
              +++D +  LQ E   K + +  +  LE  KN  +E +   E  + N ++   ++  L+
Sbjct: 1314 ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK---QVLALQ 1370

Query: 362  KEYFSKNKKLNEDI-------EEQKKVIID---LSKRLQYN-------EKSCSELQEEL- 403
             +     KK+++D+       E +KK++ D   LS+RL+         EK+ + LQ+EL 
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430

Query: 404  --VMAKKHQAFLVETCENNVKELESIL-DSFTVSGQWTSGIHKDKDKPPSFSVVLERLRR 460
               +   HQ  +    E   K+ + +L +  ++S ++     + + +          L R
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLAR 1490

Query: 461  TLTDYQNKLEDASNEEKACN-ELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCAD 519
             L +     E+   + K    +++      D   KN+ EL+     + +++  + T+   
Sbjct: 1491 ALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQL-- 1548

Query: 520  REALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVA 579
             E L   L+      L      +A  AQ E +LQ   +      EEK   L    + L A
Sbjct: 1549 -EELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE----QNEEKKRLLIKQVRELEA 1603

Query: 580  GCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRA-NEKIRHLEYICKNKSDTMREL 638
                 ++   +    +  +   +  ++++A I   N+A +E I+ L  +     D  REL
Sbjct: 1604 ELEDERKQRALA--VASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQREL 1661

Query: 639  QQ---TQEDTFTKVAE-------------QIKAQESCWHRQKKELELQYSELFLEVQKRA 682
            ++   ++++ F +  E             Q++ + +   R ++  E +  EL  E+   A
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721

Query: 683  QKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQM---SLLAACALMAGALY 739
                 + ++       I +  E+L  E S+ + L  + ++  +   +L A  A    A  
Sbjct: 1722 SGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ 1781

Query: 740  PLYSRSCALSTQRDFLQEQVNTFE-----LFKLEIRTLAQALSTVEEKKQEEA------- 787
               +    L  Q   L+ ++   E      FK  I  L   +  +EE+ ++EA       
Sbjct: 1782 KSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAAN 1841

Query: 788  KMKKKTFKGLIRIF 801
            K+ ++T K L  IF
Sbjct: 1842 KLVRRTEKKLKEIF 1855



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 178/846 (21%), Positives = 341/846 (40%), Gaps = 117/846 (13%)

Query: 21   DVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGE-- 78
            D+++ LK E      +  R++L  AK++    TT    ++A  ++QI +L+ ++ K E  
Sbjct: 1038 DLEERLKKE------EKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEE 1091

Query: 79   -----------------ALRQSLEYDLAVARKEAGLGRRAAEERLAEAHR--IQEKLCAQ 119
                             AL+   E    +A  +       A    AE  +  + E+L A 
Sbjct: 1092 LQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEAL 1151

Query: 120  NSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEER----DNMIQNCNREYDLLMKEKSR 175
             +EL+  T +T  A Q  + K ++E    +  LEE     +  IQ+  + +   ++E S 
Sbjct: 1152 KTELE-DTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSE 1210

Query: 176  LEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMH 235
              +  +      ++ K  +E+  +E A E   LQ+ + E+E +      ++ D  VQ +H
Sbjct: 1211 QLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR-----KKLDAQVQELH 1265

Query: 236  KKVEKLETEHMDCSDLLRRQTSELE-FSTQREERLRKEFEATTLRVRKLEENIEAERAAH 294
             KV + +   ++ ++   +  +EL+  ST  EE  +K  +              A+ AA 
Sbjct: 1266 AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF-------------AKDAAS 1312

Query: 295  LESKF--NSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQE 352
            LES+     E++Q   R        +K + +  +  LE  KN  +E +   E  + N ++
Sbjct: 1313 LESQLQDTQELLQEETR--------QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK 1364

Query: 353  SFAKLNLLEKEYFSKNKKLNEDI-------EEQKKVIID---LSKRLQYN-------EKS 395
               ++  L+ +     KK+++D+       E +KK++ D   LS+RL+         EK+
Sbjct: 1365 ---QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1421

Query: 396  CSELQEE---LVMAKKHQAFLVETCENNVKELESIL-DSFTVSGQWTSGIHKDKDKPPSF 451
             + LQ+E   L +   HQ  +    E   K+ + +L +  ++S ++     + + +    
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREK 1481

Query: 452  SVVLERLRRTLTDYQNKLEDASNEEKACN-ELDSTKQKIDSHTKNIKELQDKLADVNKEL 510
                  L R L +     E+   + K    +++      D   KN+ EL+     + +++
Sbjct: 1482 ETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV 1541

Query: 511  SHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFL 570
              + T+    E L   L+      L      +A  AQ E +LQ   +      EEK   L
Sbjct: 1542 EEMRTQL---EELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE----QNEEKKRLL 1594

Query: 571  HTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKN 630
                + L A          + D+     L    ++ ++  + DL         +E   K 
Sbjct: 1595 IKQVRELEA---------ELEDERKQRALAVASKKKMEIDLKDLE------AQIEAANKA 1639

Query: 631  KSDTMRELQ--QTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEI 688
            + + +++L+  Q Q   + +  E+ +A       Q KE E +   L  E+    Q  +E+
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI---LQLQEEL 1696

Query: 689  AEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCAL 748
            A     +  H E+  ++L  E ++     S    E+  L A  A +   L    S    L
Sbjct: 1697 ASSERAR-RHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755

Query: 749  STQRDFLQEQVNTFELFKLEIRTLAQALSTVE---EKKQEEAKMKKKTFKGLIRIFRKGV 805
            + +      QV+T        R+ AQ         E++ +E K K +  +G ++   K  
Sbjct: 1756 NDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKAT 1815

Query: 806  IAVLAA 811
            I+ L A
Sbjct: 1816 ISALEA 1821



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 113/607 (18%), Positives = 260/607 (42%), Gaps = 70/607 (11%)

Query: 11   DTQRLKIASLDVKQILKNET--ELDITDNLRK------KLHWAKKEKLEITTKHNAELAS 62
            D   L+    D +++L+ ET  +L+++  +R+       L   ++E+ E       ++ +
Sbjct: 1309 DAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLA 1368

Query: 63   YESQIAKLRSEVEKGEALRQSLEYDLAVARKEA-GLGRRAAEERLA------EAHRIQEK 115
             +SQ+A  + +V+      +SLE       K+A  L +R  E+ LA        +R+Q++
Sbjct: 1369 LQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQE 1428

Query: 116  LCAQNSELQAK---TNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKE 172
            L     +L  +    +  EK  +   Q   EE        EERD        +    +  
Sbjct: 1429 LDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSL 1488

Query: 173  KSRLEKTLQEALEKHQREKNEMESHIRE--TALEEFRLQEEQWEAERRELQFIVQEQDTA 230
               LE+ L EA E+ +R+  ++ + + +  ++ ++      + E  +R L+  V+E  T 
Sbjct: 1489 ARALEEAL-EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547

Query: 231  VQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQ-REERLRKEFEATTLRVRKLEENIEA 289
            ++ +  +++  E   +     ++   ++ E   Q R+E+  ++      +VR+LE  +E 
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607

Query: 290  ERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHN 349
            ER     +  + + +++ ++DLE  ++    ++ E +  L  ++ + K+    Y+RE   
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKD----YQRELEE 1663

Query: 350  AQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKH 409
            A+ S  ++    KE   K K L  +I + ++ +    +  ++ E+   EL +E+  +   
Sbjct: 1664 ARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASG 1723

Query: 410  QAFLVE---TCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQ 466
            ++ L++     E  + +LE  L+                ++  +  ++ +R R+T     
Sbjct: 1724 KSALLDEKRRLEARIAQLEEELE----------------EEQSNMELLNDRFRKTTLQVD 1767

Query: 467  NKLEDASNEEKACNELDSTKQKIDSHTKNIK-------------------ELQDKLADVN 507
                + + E  A  + D+ +Q+++   K +K                    L+ K+  + 
Sbjct: 1768 TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE 1827

Query: 508  KELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFH------K 561
            ++L     + A    L+   + +L+ +    E E+  A Q + +++K +          +
Sbjct: 1828 EQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLE 1887

Query: 562  DAEEKLT 568
            +AEE+ T
Sbjct: 1888 EAEEEAT 1894



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 83/345 (24%), Positives = 133/345 (38%), Gaps = 83/345 (24%)

Query: 9    TGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIA 68
            T D Q  +   L +KQ+ + E EL+  +  ++ L  A K+K+EI  K   +L +      
Sbjct: 1582 TRDEQNEEKKRLLIKQVRELEAELE-DERKQRALAVASKKKMEIDLK---DLEAQIEAAN 1637

Query: 69   KLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTN 128
            K R EV K     Q+   D               +  L EA   ++++ AQ+ E + K  
Sbjct: 1638 KARDEVIKQLRKLQAQMKDY--------------QRELEEARASRDEIFAQSKESEKKLK 1683

Query: 129  ETEKAFQTSQQKWKEECRRFEHDLEERDNM---IQNCNREYDLLMKEKSRLEKT---LQE 182
              E      Q++     R   H  +ERD +   I N       L+ EK RLE     L+E
Sbjct: 1684 SLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEE 1743

Query: 183  ALEKHQREKNEMESHIRETALEEFRLQEE----------------QWEAERRELQFIVQE 226
             LE+ Q     +    R+T L+   L  E                Q E + +EL+  +QE
Sbjct: 1744 ELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQE 1803

Query: 227  QDTAVQNMHKKV------------EKLETEHMD---CSDLLRRQTSELE----------- 260
             + AV++  K              E+LE E  +    + L+RR   +L+           
Sbjct: 1804 LEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERR 1863

Query: 261  FSTQREERLRK---------------EFEATTLRV--RKLEENIE 288
             + Q +E++ K               E EAT      RKL+  ++
Sbjct: 1864 HADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELD 1908



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 66/312 (21%), Positives = 135/312 (43%), Gaps = 43/312 (13%)

Query: 22   VKQILKNETELDITDNLRKKLHWAKKEKLEI---TTKHNAELASYESQIAKLRSEVEKGE 78
            +KQ+ K + ++    + +++L  A+  + EI   + +   +L S E++I +L+ E+   E
Sbjct: 1644 IKQLRKLQAQMK---DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700

Query: 79   ALRQSLEYDL-----AVARKEAGLGRRAAEERLAEAH--RIQEKLCAQNSE--------- 122
              R+  E +       +    +G      E+R  EA   +++E+L  + S          
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760

Query: 123  ---LQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEK-----S 174
               LQ  T   E A + S  +  +  R+    LE ++  ++   +E +  +K K     S
Sbjct: 1761 KTTLQVDTLNAELAAERSAAQKSDNARQ---QLERQNKELKAKLQELEGAVKSKFKATIS 1817

Query: 175  RLEKT---LQEALEKHQREKNEMESHIRETA--LEEFRLQEEQWEAERRELQFIVQEQDT 229
             LE     L+E LE+  +E+      +R T   L+E  +Q E       + +  +++ + 
Sbjct: 1818 ALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANA 1877

Query: 230  AVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRK-----LE 284
             ++ + +++E+ E E    +   R+   EL+ +T+  E L +E      R+R+       
Sbjct: 1878 RMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFS 1937

Query: 285  ENIEAERAAHLE 296
             +    R  HLE
Sbjct: 1938 SSRSGRRQLHLE 1949



 Score = 39.3 bits (90), Expect = 0.025
 Identities = 49/245 (20%), Positives = 100/245 (40%), Gaps = 20/245 (8%)

Query: 1048 REEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQ 1107
            R+E+     +E+  +++E   K+E    E   K+Q L E    L+E   +L+ + +   +
Sbjct: 849  RQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAE---QLQAETELFAE 905

Query: 1108 LNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSA 1167
                  +L   K+ LEE +HD ES +    +  + + N  + ++  +  + +Q+     A
Sbjct: 906  AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965

Query: 1168 ASRNDFTLQLPKLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQLASTRIMTLEKEMTSH 1227
              +    LQL K+  E    +  K   E++  +     F+   +L   RI     ++   
Sbjct: 966  RQK----LQLEKVTAEA---KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018

Query: 1228 RSHIAAL-----KSELHTACLRENASLQSIGSRDHSNLSIPSRAPLPADTTGIGD-FLPL 1281
                  L     K E+  + L E    +    ++       ++  L  +TT + D    L
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK----AKRKLDGETTDLQDQIAEL 1074

Query: 1282 KAELD 1286
            +A++D
Sbjct: 1075 QAQID 1079


>gi|32698688 citron [Homo sapiens]
          Length = 2027

 Score =  106 bits (265), Expect = 1e-22
 Identities = 186/856 (21%), Positives = 349/856 (40%), Gaps = 134/856 (15%)

Query: 16   KIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVE 75
            K +S++ K ++K++   D  D    K H   K + E+T  H   ++  E+ +++   E++
Sbjct: 443  KTSSMEKKLLIKSKELQDSQD----KCH---KMEQEMTRLHR-RVSEVEAVLSQKEVELK 494

Query: 76   KGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQ 135
              E  R  LE DLA    E    +R+ E+   E                  + E +KA Q
Sbjct: 495  ASETQRSLLEQDLATYITECSSLKRSLEQARMEV-----------------SQEDDKALQ 537

Query: 136  TSQQKWKEECRRFEHDLEERDNMIQNCN-REYDLLMKEKSRLEKTLQEALEKHQREKNEM 194
                          HD+ E+   +Q    +EY   ++E   +   L+E L   +R  +  
Sbjct: 538  LL------------HDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLY 585

Query: 195  ESHIRETAL--EEFRLQEEQWE--------------AERRELQFIVQEQDTAVQNMHKKV 238
            ES +RE+ L  EEF+ +  + +               E  +L+ I  EQ   +Q + +K+
Sbjct: 586  ESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKL 645

Query: 239  EKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESK 298
            EK      + ++LL+      E + +  E+L+   +++    +KL E  E E   H E++
Sbjct: 646  EKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEE-KHREAQ 704

Query: 299  FNSEIIQLRIRD----LEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESF 354
             +++ +++ ++      E  ++V      + +AD E ++N  +  E     +     E  
Sbjct: 705  VSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQK 764

Query: 355  AKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLV 414
            A +N ++ +  S  +++ E + E  K+  + S   Q N K+    QEE++   + Q F +
Sbjct: 765  AMINAMDSKIRSLEQRIVE-LSEANKLAANSSLFTQRNMKA----QEEMISELRQQKFYL 819

Query: 415  ET----CENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLE-----------RLR 459
            ET     E   ++LE  L+  +         H DK++       L             L+
Sbjct: 820  ETQAGKLEAQNRKLEEQLEKISHQD------HSDKNRLLELETRLREVSLEHEEQKLELK 873

Query: 460  RTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIK-ELQDKLADVNKELSHLHTKCA 518
            R LT+ Q  L++    E     L + +  ++S  +  K EL++  A+  +E+  L     
Sbjct: 874  RQLTELQLSLQE---RESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 930

Query: 519  DREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKD------AEEKLTFLHT 572
            + +     L+     V+   E++  Q  +  +EL   +    K       A +++  L +
Sbjct: 931  EIQRKFDALRNSC-TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRS 989

Query: 573  LYQHLVAGCV-----LIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLE-- 625
               HL          L  Q + M    +    C +L+E V  L A  +   EK R  E  
Sbjct: 990  EVDHLRREITEREMQLTSQKQTM---EALKTTCTMLEEQVMDLEALNDELLEKERQWEAW 1046

Query: 626  --YICKNKSDTMRELQQTQEDTFTKVAEQIKA-QESCWHRQKKELELQYSELFLEVQKRA 682
               +   KS     +++ Q    T+   + +A Q     RQ  EL ++  +  +   ++A
Sbjct: 1047 RSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQA 1106

Query: 683  QKFQEI-AEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQR--------EQMSLLAACAL 733
             K Q++ AE   +KLN +EK H  L +     ++ L +T+R        EQ  L     L
Sbjct: 1107 LKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL-ETERELKQRLLEEQAKLQQQMDL 1165

Query: 734  MAGALYPL-------YSRSCALSTQRDFLQEQVNTFELF------KLE--IRTLAQALST 778
                ++ L         R+  L T+R  L+ Q+   ++       K+E  I    + +  
Sbjct: 1166 QKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDF 1225

Query: 779  VEEKKQEEAKMKKKTF 794
            ++ K  + AK KK  F
Sbjct: 1226 LQAKMDQPAKKKKGLF 1241



 Score = 78.2 bits (191), Expect = 5e-14
 Identities = 130/593 (21%), Positives = 260/593 (43%), Gaps = 67/593 (11%)

Query: 16   KIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSE-V 74
            KI  LD  QI K+  + +  +N+ ++      EK +I ++  A + + +S+I  L    V
Sbjct: 724  KIKVLD-NQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV 782

Query: 75   EKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAF 134
            E  EA + +    L   R       +A EE ++E  + +  L  Q  +L+A+  + E+  
Sbjct: 783  ELSEANKLAANSSLFTQRN-----MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL 837

Query: 135  QT-SQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEA---LEKHQRE 190
            +  S Q   ++ R  E +   R+  +++  ++ +L  ++ + L+ +LQE    L   Q  
Sbjct: 838  EKISHQDHSDKNRLLELETRLREVSLEHEEQKLEL-KRQLTELQLSLQERESQLTALQAA 896

Query: 191  KNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQD-------------TAVQNMHKK 237
            +  +ES +R+   E   L+E   EAE  E+Q +   +D             T + ++ ++
Sbjct: 897  RAALESQLRQAKTE---LEETTAEAEE-EIQALTAHRDEIQRKFDALRNSCTVITDLEEQ 952

Query: 238  VEKLETEHMDCSD---LLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAH 294
            + +L  ++ + ++    L +Q  E   +     +LR E +     + + E  + +++   
Sbjct: 953  LNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTM 1012

Query: 295  LESKFNSEIIQLRIRDLEGALQ--VEKASQAEAVAD-LEIIKNEF----KEVESAYEREK 347
               K    +++ ++ DLE      +EK  Q EA    L   K++F    +E++   + EK
Sbjct: 1013 EALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEK 1072

Query: 348  HNAQ-------ESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEK------ 394
             +         ES   + L  KE+ ++   L + ++EQK     LS +L   EK      
Sbjct: 1073 QSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLE 1132

Query: 395  -SCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSV 453
             +   LQ++L   ++ +  L+E      ++++   +      + T G+ +  D+      
Sbjct: 1133 MNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIF---RLTQGLQEALDRAD---- 1185

Query: 454  VLERLRRTLTDYQ-NKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSH 512
             L +  R+  +YQ   ++   + EK   +++ T   I   TK I  LQ K+    K+   
Sbjct: 1186 -LLKTERSDLEYQLENIQVLYSHEKV--KMEGT---ISQQTKLIDFLQAKMDQPAKKKKG 1239

Query: 513  LHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEE 565
            L ++  +  AL + + ++   +    EKEKA+ A+ E  LQK         EE
Sbjct: 1240 LFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREE 1292



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 65/293 (22%), Positives = 116/293 (39%), Gaps = 44/293 (15%)

Query: 974  KQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQ----SKL 1029
            K+ L    + H  E   +   L  +E K  +N M  ++   +   ++L+E  +    S L
Sbjct: 739  KETLENMMQRHEEEAHEKGKIL--SEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSL 796

Query: 1030 ITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLE-----LHSSEEADKNQTL 1084
             T    + A EE+ + L    Q +  L  QA +L+  N KLE     +   + +DKN+ L
Sbjct: 797  FTQRNMK-AQEEMISEL---RQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLL 852

Query: 1085 G------EAVKSLSEAKMELRRK----DQSLRQLNRHLT-----------QLEQDKRRLE 1123
                   E      E K+EL+R+      SL++    LT           QL Q K  LE
Sbjct: 853  ELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 912

Query: 1124 ENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLE 1183
            E   +AE  ++     ++ +     A+ N+   + D +    +  + ++  L     +L 
Sbjct: 913  ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD-LEEQLNQLTEDNAELNNQNFYLS 971

Query: 1184 TFAMEGLKGGPEVVACQAMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKS 1236
                E      E+V  ++ +             I   E ++TS +  + ALK+
Sbjct: 972  KQLDEASGANDEIVQLRSEVDHL-------RREITEREMQLTSQKQTMEALKT 1017



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 135/722 (18%), Positives = 266/722 (36%), Gaps = 98/722 (13%)

Query: 604  QENVDALIADLNRANEKIRHLEYICKNK------SDTMRELQQTQEDTFTKVAEQIKAQE 657
            Q+    +  ++ R + ++  +E +   K      S+T R L +    T+      +K   
Sbjct: 462  QDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSL 521

Query: 658  SCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLL 717
                 +  + + +  +L  +++++++K QEI E+  +      +  E  ++ N   + L+
Sbjct: 522  EQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQA-----QVEEMRLMMNQLEEDLV 576

Query: 718  SQTQREQM--SLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQA 775
            S  +R  +  S L    L A   +   +  C     +   Q +    E  KLE     Q 
Sbjct: 577  SARRRSDLYESELRESRLAAEE-FKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQ 635

Query: 776  LSTVEEKKQEEAKMKKKT-FKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEG 834
            L   E +++ E  +K  T    L++  R+      A   L+ L           E   EG
Sbjct: 636  LKIQELQEKLEKAVKASTEATELLQNIRQA--KERAERELEKLQNR--------EDSSEG 685

Query: 835  IGM-LVCTGEPQDKHKFPK---------------HQKEQLRCL--QALSWLTSSDLLAAI 876
            I   LV   E ++KH+  +               H +E+++ L  Q    L   + L  +
Sbjct: 686  IRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENM 745

Query: 877  ISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSI----T 932
            +    E     GK     +     +I A  +    L  +I  + E   L ++ S+     
Sbjct: 746  MQRHEEEAHEKGKILSEQKA----MINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRN 801

Query: 933  YVEKDSLVQRLAHGLHKVNTLALKYGLRGHV------PITKSTASLQKQILGFTQRLHAA 986
               ++ ++  L      + T A K   +          I+    S + ++L    RL   
Sbjct: 802  MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREV 861

Query: 987  EVERRSLRLEV----TEFKRSVNEMKKELDKAQGLQMQL-NEFKQSKLITHEKFESACEE 1041
             +E    +LE+    TE + S+ E + +L   Q  +  L ++ +Q+K    E    A EE
Sbjct: 862  SLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEE 921

Query: 1042 LNNALLREEQAQML-------------LNEQAQQLQELNYKLE---LHSSEEADKNQTLG 1085
            +       ++ Q               L EQ  QL E N +L     + S++ D+     
Sbjct: 922  IQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN 981

Query: 1086 EAV-----------KSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALR 1134
            + +           + ++E +M+L  + Q++  L    T LE+    LE    +     R
Sbjct: 982  DEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKER 1041

Query: 1135 MAAKDKECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGP 1194
                 +  + +     E  + +++  +     + +R D  +   +  +E    E      
Sbjct: 1042 QWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKE---HKA 1098

Query: 1195 EVVACQAMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHT------ACLRENAS 1248
            E++A Q  +K      +  S ++  LEK+      +  +L+ +L T        L E A 
Sbjct: 1099 EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAK 1158

Query: 1249 LQ 1250
            LQ
Sbjct: 1159 LQ 1160


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  106 bits (265), Expect = 1e-22
 Identities = 232/1171 (19%), Positives = 490/1171 (41%), Gaps = 178/1171 (15%)

Query: 41   KLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAG---L 97
            KL++  K  L+ + +   E+A+ + +  K + E+ K EA R+ LE  +    +E     L
Sbjct: 835  KLYFKIKPLLK-SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893

Query: 98   GRRAAEERLAEAHRIQEKLCAQNSELQAKTNE-TEKA---------FQTSQQKWKEECRR 147
              +A  + LA+A    ++L     +L+AK  E TE+A             ++K ++EC  
Sbjct: 894  QVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953

Query: 148  FEHDLEERDNMIQNCNREYDLLMKEKSRLEKT---LQEALEKHQREKNEMESHIRETALE 204
             + D+++ +  +    +E      +   L +    L E + K  +EK  ++   ++T L+
Sbjct: 954  LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT-LD 1012

Query: 205  EFRLQEEQ----------WEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRR 254
            + +++E++           E +  +L+  ++++     ++ +   KLE       DL   
Sbjct: 1013 DLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLE------GDLKLA 1066

Query: 255  QTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGA 314
            Q S ++    +++ L ++ +     +  L+  IE E+A  ++ +   + +Q RI +LE  
Sbjct: 1067 QESTMDTENDKQQ-LNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEE 1125

Query: 315  LQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKK-LNE 373
            ++ E+AS+A+A      +  E +E+    E E   A  +  ++N   +  F K ++ L E
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLE-EAGGATSAQIEMNKKREAEFQKMRRDLEE 1184

Query: 374  DIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTV 433
               + +     L K+   +  S +EL E++   ++    + +  E    EL+  ++    
Sbjct: 1185 STLQHEATAAALRKK---HADSVAELGEQIDSLQR----VKQKLEKEKSELKMEINDLAS 1237

Query: 434  SGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNE-EKACNELDSTKQKIDSH 492
            + +  S    +           E++ RTL D  ++++    E ++  NEL + K ++ + 
Sbjct: 1238 NMETVSKAKAN----------FEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTE 1287

Query: 493  TKNI-KELQDKLADVN----------KELSHLHTKCADREALISTLKVELQNVLH----- 536
            +    ++L +K A V+          +++  L  +  +     STL   LQ+  H     
Sbjct: 1288 SGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLL 1347

Query: 537  ---CWEKEKAQA------AQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQP 587
                 E+++A+A      +++ SE+ +    +  DA ++   L    + L       ++ 
Sbjct: 1348 REQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEH 1407

Query: 588  EGMLDK--FSWSELCAVLQENVDALIADLNRAN-------EKIRHLEYIC----KNKSDT 634
               ++    S  +    LQ  V+ L+ D+ R+N       +K R+ + +     +   +T
Sbjct: 1408 VEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEET 1467

Query: 635  MRELQQTQEDTFTKVAEQIKA----QESCWH-----RQKKELELQYSELFLEVQKRAQKF 685
              EL+ +Q+++ +   E  K     +ES  H     R+ K L+ + S+L  ++ +  +  
Sbjct: 1468 QAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHI 1527

Query: 686  QEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRS 745
             E+ EK  ++L+H EKS  Q  LE +      +  + E+  +L            L    
Sbjct: 1528 HEL-EKVKKQLDH-EKSELQTSLEEAE-----ASLEHEEGKILR---------IQLELNQ 1571

Query: 746  CALSTQRDFLQEQVNTFELFKLEIRTLAQALSTV--EEKKQEEAKMKKKTFKGLIRIFRK 803
                  R   ++     +L +  +R +    ST+  E + + +A   KK  +G +     
Sbjct: 1572 VKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEME- 1630

Query: 804  GVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTG-EPQDKHKFPKHQKEQLRCLQ 862
              I +  ANR     Q+  +L     + +   G+L  T     D  +     KEQL  ++
Sbjct: 1631 --IQLNHANR-----QAAEAL----RNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVE 1679

Query: 863  ALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMEC 922
              + L  ++        + EL+  + + +   ++    L+ A++          SL+   
Sbjct: 1680 RRANLMQAE--------VEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTK 1731

Query: 923  IPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQR 982
              L +  S    E + +VQ   +   K                  + A++  + L   Q 
Sbjct: 1732 KKLETDISQIQGEMEDIVQEARNAEEKAKKAI-------------TDAAMMAEELKKEQD 1778

Query: 983  LHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEEL 1042
              +A +ER    +E T     V +++  LD+A+ L ++  + KQ      +K E+   EL
Sbjct: 1779 T-SAHLERMKKNMEQT-----VKDLQLRLDEAEQLALKGGK-KQI-----QKLEARVREL 1826

Query: 1043 NNALLREE----QAQMLLNEQAQQLQELNYKLE------LHSSEEADKNQTLGEAVKSLS 1092
             + +  E+    +A   L +  ++++EL Y+ E      L   +  DK QT  +A K  +
Sbjct: 1827 ESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQA 1886

Query: 1093 EAKMELRRKDQSLRQLNRHLTQLEQDKRRLE 1123
            E   E  + + +L +  +   +LE+ K R +
Sbjct: 1887 EEAEE--QSNVNLAKFRKLQHELEEAKERAD 1915



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 168/825 (20%), Positives = 344/825 (41%), Gaps = 118/825 (14%)

Query: 30   TELDITDNLRKKLHWAK--KEKLEITTKHNAELAS----YESQIAKLRSEVEKGEALRQS 83
            T   I  N +++  + K  ++  E T +H A  A+    +   +A+L  +++  + ++Q 
Sbjct: 1161 TSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQK 1220

Query: 84   LEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCA----QNSELQAKTNETEKAF-QTSQ 138
            LE + +  + E      +  E +++A    EK+C     Q SE++ K  E ++   + S 
Sbjct: 1221 LEKEKSELKMEIN-DLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSA 1279

Query: 139  QKWK--EECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMES 196
            QK +   E   F   L+E+D M+   +R      ++   L++ L+E     + +     +
Sbjct: 1280 QKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEE-----ETKAKSTLA 1334

Query: 197  HIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQT 256
            H  ++A  +  L  EQ+E E+     + +    A   + +   K ET+ +  ++ L    
Sbjct: 1335 HALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394

Query: 257  SELEFSTQREERLRKEFEATTLRVRKLEENI-----EAERAAHLESKFNSEIIQL--RIR 309
             +L    QR +   +  EA   +   LE+       E E       + N+  I L  + R
Sbjct: 1395 KKL---AQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQR 1451

Query: 310  DLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNK 369
            + +  L   K    E  A+LE  + E + + +   + K+  +ES   L  L++E  +  +
Sbjct: 1452 NFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQ 1511

Query: 370  K---LNEDIEEQKKVIIDLSKRLQYNEKSCSELQ---EELVMAKKHQAFLVETCENNVKE 423
            +   L E I E  K I +L K  +  +   SELQ   EE   + +H+   +   +  + +
Sbjct: 1512 EISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQ 1571

Query: 424  LESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELD 483
            ++S +D             K  +K      +     R +   Q+ L+    E ++ N+  
Sbjct: 1572 VKSEID------------RKIAEKDEELDQLKRNHLRVVESMQSTLDA---EIRSRNDAL 1616

Query: 484  STKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKA 543
              K+K++    ++ E++ +L   N++ +       + + ++   ++ L + +   +  K 
Sbjct: 1617 RIKKKMEG---DLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKE 1673

Query: 544  QAAQSE-------SELQKLSQAFHK-------------DAEEKLTFLHTLYQHLVAGCVL 583
            Q A  E       +E+++L  +  +             DA E++  LHT    L+     
Sbjct: 1674 QLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKK 1733

Query: 584  IKQPEGMLDKFSWSELCAVLQENVDA-------------LIADLNRANEKIRHLEYICKN 630
            ++     +      E+  ++QE  +A             +  +L +  +   HLE + KN
Sbjct: 1734 LETDISQIQ----GEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789

Query: 631  KSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAE 690
               T+++LQ   ++     AEQ+  +     +Q ++LE +  EL  EV+   QK    A 
Sbjct: 1790 MEQTVKDLQLRLDE-----AEQLALKGG--KKQIQKLEARVRELESEVESE-QKHNVEAV 1841

Query: 691  KNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALST 750
            K + K       HE+ V      K+L  QT+ ++ ++L     +   +  L ++  A   
Sbjct: 1842 KGLRK-------HERRV------KELTYQTEEDRKNILR----LQDLVDKLQTKVKAYKR 1884

Query: 751  QRDFLQEQ--VNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKT 793
            Q +  +EQ  VN  +  KL+   L +A    +  + +  K++ K+
Sbjct: 1885 QAEEAEEQSNVNLAKFRKLQ-HELEEAKERADIAESQVNKLRVKS 1928



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 150/832 (18%), Positives = 340/832 (40%), Gaps = 112/832 (13%)

Query: 26   LKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLE 85
            L  E+ +D T+N +++L+   K+K    +    ++   ++   +L+ ++++ +A  + LE
Sbjct: 1065 LAQESTMD-TENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELE 1123

Query: 86   YDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEEC 145
             ++   R      R  AE++ ++  R  E++  +  E    T+   +  +  + ++++  
Sbjct: 1124 EEIEAER----ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR 1179

Query: 146  RRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETA--L 203
            R  E    + +       +++   + E      +LQ   +K ++EK+E++  I + A  +
Sbjct: 1180 RDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNM 1239

Query: 204  EEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFST 263
            E     +  +E   R L+  + E  T  +   + + +L  +        R  T   EFS 
Sbjct: 1240 ETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQK------ARLHTESGEFSR 1293

Query: 264  QREER------LRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQV 317
            Q +E+      L +  +A T ++ +L+  +E E  A                 L  ALQ 
Sbjct: 1294 QLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAK--------------STLAHALQ- 1338

Query: 318  EKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEE 377
                   A  D ++++ +++E + A    +    ++ +++     +Y +   +  E++EE
Sbjct: 1339 ------SARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEE 1392

Query: 378  QKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQW 437
             KK    L++RLQ       + +E +       A L +T +    E+E ++     S   
Sbjct: 1393 AKK---KLAQRLQ-------DAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAA 1442

Query: 438  TSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEE--------KACNELDSTKQKI 489
               + K   K  +F  VL   ++   + Q +LE +  E         K  N  + +   +
Sbjct: 1443 CIALDK---KQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHL 1499

Query: 490  DSHTKNIKELQDKLADVNKELS----HLH-----TKCADREALISTLKVELQNVLHCWEK 540
            ++  +  K LQ +++D+ ++++    H+H      K  D E   S L+  L+      E 
Sbjct: 1500 ETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEK--SELQTSLEEAEASLEH 1557

Query: 541  EKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELC 600
            E+ +  + + EL ++     +   EK   L  L ++ +    +++  +  LD    S   
Sbjct: 1558 EEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLR---VVESMQSTLDAEIRSRND 1614

Query: 601  AV-----LQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKA 655
            A+     ++ +++ +   LN AN +        +N    +++ Q   +D   +  + +K 
Sbjct: 1615 ALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAI-RGQDDLKE 1673

Query: 656  QESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNM----EKLNHIEKSHEQLVLENS 711
            Q +   R+   ++ +  EL   ++ R ++ +++AE+ +    E++  +   +  L+    
Sbjct: 1674 QLAMVERRANLMQAEVEELRASLE-RTERGRKMAEQELLDASERVQLLHTQNTSLINTKK 1732

Query: 712  HFKKLLSQTQREQMSL--------------LAACALMAGALYPLYSRSCALSTQRDFLQE 757
              +  +SQ Q E   +              +   A+MA  L      S  L   +  +++
Sbjct: 1733 KLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1792

Query: 758  QVNTFEL------------FKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGL 797
             V   +L             K +I+ L   +  +E + + E K   +  KGL
Sbjct: 1793 TVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGL 1844



 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 97/436 (22%), Positives = 179/436 (41%), Gaps = 74/436 (16%)

Query: 19   SLDVKQILKNETE------LDITDNLR---KKLHWAKKEKLEITTKHNAELASYESQIAK 69
            SLD  + LK E +       D+T+ +    K +H  +K K ++  + +    S E   A 
Sbjct: 1495 SLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEAS 1554

Query: 70   LRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAE-ERLAEAH-RIQEKLCAQNSELQAKT 127
            L  E E+G+ LR  LE +   +  +  +  +  E ++L   H R+ E +    S L A+ 
Sbjct: 1555 L--EHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESM---QSTLDAEI 1609

Query: 128  NETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREY-----------------DLLM 170
                 A +          ++ E DL E +  + + NR+                   L +
Sbjct: 1610 RSRNDALRIK--------KKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHL 1661

Query: 171  KEKSRLEKTLQEALEKHQREKNEMESHIRETAL-----EEFRLQEEQWEAERRELQFIVQ 225
             +  R +  L+E L   +R  N M++ + E        E  R   EQ   +  E   ++ 
Sbjct: 1662 DDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLH 1721

Query: 226  EQDTAVQNMHKKVE--------KLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATT 277
             Q+T++ N  KK+E        ++E    +  +   +    +  +    E L+KE + T+
Sbjct: 1722 TQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKE-QDTS 1780

Query: 278  LRVRKLEENIE------------AERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEA 325
              + ++++N+E            AE+ A    K   + ++ R+R+LE  ++ E+    EA
Sbjct: 1781 AHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEA 1840

Query: 326  VADLEIIKNEFKEVESAYEREKHN---AQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVI 382
            V  L   +   KE+    E ++ N    Q+   KL    K Y    K+  E+ EEQ  V 
Sbjct: 1841 VKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAY----KRQAEEAEEQSNVN 1896

Query: 383  IDLSKRLQYNEKSCSE 398
            +   ++LQ+  +   E
Sbjct: 1897 LAKFRKLQHELEEAKE 1912



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 175/951 (18%), Positives = 349/951 (36%), Gaps = 135/951 (14%)

Query: 299  FNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLN 358
            F S I+    +     L      + + +   +  +     +E  + + K    + F K  
Sbjct: 713  FPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIEIDHTQYKFGHTKVFFKAG 772

Query: 359  LLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKS-------CSELQEELVMAKKHQA 411
            LL      +++KL + I   + +      R+++ +         C +      M  KH  
Sbjct: 773  LLGTLEEMRDEKLAQLITRTQAICRGFLMRVEFRKMMERRESIFCIQYNIRAFMNVKHWP 832

Query: 412  F---------LVETCENNVKELESILDSFTVSGQWTSGIH-KDKDKPPSFSVVLERLRRT 461
            +         L+++ E   KE+ ++ + F  + +  +    K K+       +++     
Sbjct: 833  WMKLYFKIKPLLKSAETE-KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL 891

Query: 462  LTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELS----HLHTKC 517
                Q + +  ++ E+ C++L  TK ++++  K + E  +   ++N EL+     L  +C
Sbjct: 892  QLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 951

Query: 518  ADREALISTLKVELQNVLHCWEKEKAQAAQS----ESELQKLSQAFHKDAEEKLTFLHTL 573
            ++ +  I  L++ L  V    EKEK            E+  L +   K  +EK   L   
Sbjct: 952  SELKKDIDDLELTLAKV----EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKA-LQEA 1006

Query: 574  YQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVD----------ALIADLNRANEKIR- 622
            +Q  +    + +     L K         L++ VD           L  DL RA  K+  
Sbjct: 1007 HQQTLDDLQMEEDKVNTLTKAKTK-----LEQQVDDLEGSLEQEKKLCMDLERAKRKLEG 1061

Query: 623  HLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRA 682
             L+   ++  DT  + QQ  E    K  E    Q      Q   ++LQ  +   E+Q R 
Sbjct: 1062 DLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQ--KKIKELQARI 1119

Query: 683  QKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLY 742
            ++ +E  E         EK    L  E     + L     E+     +  +         
Sbjct: 1120 EELEEEIEAERASRAKAEKQRSDLSRELEEISERL-----EEAGGATSAQIEMNKKREAE 1174

Query: 743  SRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFR 802
             +      +   LQ +     L K    ++A+    ++  ++ + K++K+          
Sbjct: 1175 FQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEK--------- 1225

Query: 803  KGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQ 862
                     + LK+     AS    +   K     +  T E Q   +    ++EQ R + 
Sbjct: 1226 ---------SELKMEINDLASNMETVSKAKANFEKMCRTLEDQ-LSEIKTKEEEQQRLIN 1275

Query: 863  ALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVME- 921
             LS        A       E  +   + D    +   L  G  K +F + ++++   +E 
Sbjct: 1276 ELS--------AQKARLHTESGEFSRQLDEKDAMVSQLSRG--KQAFTQQIEELKRQLEE 1325

Query: 922  --------CIPLHSSRSIT------YVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITK 967
                       L S+R         Y E+      L  G+ K N+   ++  +      +
Sbjct: 1326 ETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQ 1385

Query: 968  STASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKA-QGLQMQLNEFKQ 1026
             T  L++      QRL  AE           E   +VN     L+K  Q LQ ++ +   
Sbjct: 1386 RTEELEEAKKKLAQRLQDAE-----------EHVEAVNSKCASLEKTKQRLQNEVEDL-- 1432

Query: 1027 SKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGE 1086
              +I  E+  +AC  L+    ++     +L E  Q+ +E   +LE    E    +  L +
Sbjct: 1433 --MIDVERSNAACIALDK---KQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFK 1487

Query: 1087 AVKSLSEAKME----LRRKDQSLRQL-----------NRHLTQLEQDKRRLEENIHDAES 1131
             VK+  E  ++    L+R++++L+Q             +H+ +LE+ K++L+    + ++
Sbjct: 1488 -VKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQT 1546

Query: 1132 ALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHL 1182
            +L  A    E     +  ++  L++V+ +I      A +++   QL + HL
Sbjct: 1547 SLEEAEASLEHEEGKILRIQLELNQVKSEIDR--KIAEKDEELDQLKRNHL 1595



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 67/283 (23%), Positives = 126/283 (44%), Gaps = 27/283 (9%)

Query: 59   ELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCA 118
            +LA  E +   +++EVE+   LR SLE      R E G  R+ AE+ L +A    + L  
Sbjct: 1674 QLAMVERRANLMQAEVEE---LRASLE------RTERG--RKMAEQELLDASERVQLLHT 1722

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEK 178
            QN+ L     + E      Q + ++  +   +  E+    I +       +M E+ + E+
Sbjct: 1723 QNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDA-----AMMAEELKKEQ 1777

Query: 179  TLQEALEKHQREKNEMESHIRETALEEFRLQE-EQWEAERRELQFIVQEQDTAVQNMHKK 237
                 LE   R K  ME  +++  L   RL E EQ   +  + Q  +Q+ +  V+ +  +
Sbjct: 1778 DTSAHLE---RMKKNMEQTVKDLQL---RLDEAEQLALKGGKKQ--IQKLEARVRELESE 1829

Query: 238  VEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLES 297
            VE  +  +++    LR+    ++  T + E  RK        V KL+  ++A +    E+
Sbjct: 1830 VESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEA 1889

Query: 298  KFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVE 340
            +  S +   + R L+   ++E+A +   +A+ ++ K   K  E
Sbjct: 1890 EEQSNVNLAKFRKLQH--ELEEAKERADIAESQVNKLRVKSRE 1930



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 68/317 (21%), Positives = 126/317 (39%), Gaps = 62/317 (19%)

Query: 964  PITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKE--LDKAQGLQMQL 1021
            P+ KS A  +K++    +     E E+    L  TE KR   E K    + +   LQ+Q+
Sbjct: 842  PLLKS-AETEKEMANMKE-----EFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQV 895

Query: 1022 NEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKL----------- 1070
                Q++       E  C++L    ++ E     + E+A+  +E+N +L           
Sbjct: 896  ----QAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 951

Query: 1071 -------------------ELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRH 1111
                               E H++E   KN T  E +  L E   +L ++ ++L++ ++ 
Sbjct: 952  SELKKDIDDLELTLAKVEKEKHATENKVKNLT--EEMAGLDETIAKLTKEKKALQEAHQQ 1009

Query: 1112 L---TQLEQD--------KRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQ 1160
                 Q+E+D        K +LE+ + D E +L    K    +    R +E  L   ++ 
Sbjct: 1010 TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQES 1069

Query: 1161 ISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGPEVVACQAMIKSFMDVYQLASTRIMTL 1220
                 +  + ND      KL  + F M  L+G  ++   QA+        +    RI  L
Sbjct: 1070 -----TMDTENDKQQLNEKLKKKEFEMSNLQG--KIEDEQALAIQLQKKIKELQARIEEL 1122

Query: 1221 EKEMTSHRSHIAALKSE 1237
            E+E+ + R+  A  + +
Sbjct: 1123 EEEIEAERASRAKAEKQ 1139



 Score = 39.3 bits (90), Expect = 0.025
 Identities = 43/206 (20%), Positives = 92/206 (44%), Gaps = 15/206 (7%)

Query: 994  RLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQ 1053
            +L+  EF+ S  + K E ++A  +Q+Q    +    I   + E   E  + A   ++++ 
Sbjct: 1083 KLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1142

Query: 1054 ML--LNEQAQQLQEL----NYKLELHSSEEAD---KNQTLGEAVKSLSEAKMELRRKD-Q 1103
            +   L E +++L+E     + ++E++   EA+     + L E+          LR+K   
Sbjct: 1143 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD 1202

Query: 1104 SLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISL 1163
            S+ +L   +  L++ K++LE+   + +  +   A + E V+      E     + DQ+S 
Sbjct: 1203 SVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSE 1262

Query: 1164 SWSAASR-----NDFTLQLPKLHLET 1184
              +         N+ + Q  +LH E+
Sbjct: 1263 IKTKEEEQQRLINELSAQKARLHTES 1288


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score =  106 bits (264), Expect = 2e-22
 Identities = 194/867 (22%), Positives = 345/867 (39%), Gaps = 144/867 (16%)

Query: 20   LDVKQILKNETELDITDNLRKKLHWAKKEKLEITTK-HNAELASYESQIAKLRSEVEKGE 78
            L+ K +L  E +L+ T     KLH  +KE L++  K H+ E+   +    K+   +E+  
Sbjct: 357  LETKTML--EDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER-DMDRKKIEELMEENM 413

Query: 79   AL----RQSLEYDLAVARKEAGLGRRAAEERLAEA------HRIQE-------KLCAQNS 121
             L    +QS++  L +  +   + R +    L+EA      H + E       KL  +N 
Sbjct: 414  TLEMAQKQSMDESLHLGWELEQISRTS---ELSEAPQKSLGHEVNELTSSRLLKLEMENQ 470

Query: 122  ELQAKTNETEKA-------------FQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDL 168
             L     E                  +   Q+  ++    E+++ +    +QNC      
Sbjct: 471  SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKD 530

Query: 169  LMKEKSRLEKTLQ----------EALEKHQREKNEMESHIRETALEEFRLQEEQWEAERR 218
            LMKEK++LEKT++          + LE+     N+  S +R+ +      + +  E E +
Sbjct: 531  LMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590

Query: 219  ELQFIVQEQDTAVQNMH-----------------KKVEKLETE--HMDC-SDLLRRQTSE 258
             L   ++E  + +  +                  ++ E+LE E  H++  ++LL+++ + 
Sbjct: 591  ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650

Query: 259  LEFSTQREERLRKEFEATTLRVRKLEENIEAER--AAHLESKFNSEIIQLRIRDLEGALQ 316
            L+ + ++ E L +E        RKL++ +++ +     LES    E  QL   +LE    
Sbjct: 651  LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES-LEKENSQLDEENLELRRN 709

Query: 317  VEKASQAE-AVADLEIIKNEFKEVESAYEREKHNAQ---ESFAKLNLLEKEYFS---KNK 369
            VE    A   +A L++   E KE+ES  E+ K   +    SF K   LE  Y     +N+
Sbjct: 710  VESLKCASMKMAQLQL---ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766

Query: 370  KLNEDIEEQKKVIIDLSKRLQYNEKSCSELQ---EELVMAKKHQAFLVETCENNVKELES 426
            +L + +E   K I  L   LQ  E     LQ   EEL ++ K     +E  E   K LE 
Sbjct: 767  RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR----LEQLEKENKSLE- 821

Query: 427  ILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEK--ACNELDS 484
                     Q TS + KDK +       LE+  + L   Q +++D + EE       L+ 
Sbjct: 822  ---------QETSQLEKDKKQ-------LEKENKRLRQ-QAEIKDTTLEENNVKIGNLEK 864

Query: 485  TKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQ 544
              + +       KE   +L ++ KE   L  +       + TL+ +L +       EK +
Sbjct: 865  ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS-------EKLK 917

Query: 545  AAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQ 604
              Q  ++L+KL+    K    K   LH             K  E  L+  +  +   + +
Sbjct: 918  TQQMNNDLEKLTHELEKIGLNKERLLH---DEQSTDDSRYKLLESKLES-TLKKSLEIKE 973

Query: 605  ENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQ-EDTFTKVAEQIKAQESCWHRQ 663
            E + AL A L  +    + L    K        L+Q Q E+   + +  I  +++ W R+
Sbjct: 974  EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1033

Query: 664  KKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQRE 723
             +E   +     L+V+              ++L  +E+++  L  E    K  L Q + +
Sbjct: 1034 SQETTRE----LLKVK--------------DRLIEVERNNATLQAEKQALKTQLKQLETQ 1075

Query: 724  QMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTF-----ELFKLEIRTLAQALST 778
              +L A    +      L  ++  L TQ   LQ + +T       L     + L Q  S 
Sbjct: 1076 NNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSL 1135

Query: 779  VEEKKQ--EEAKMKKKTFKGLIRIFRK 803
              E +   +E +  K  +  LI+   K
Sbjct: 1136 ENENESVIKEREDLKSLYDSLIKDHEK 1162



 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 216/1079 (20%), Positives = 419/1079 (38%), Gaps = 196/1079 (18%)

Query: 126  KTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALE 185
            K  E+ +         K + RR   +LEE+   + +C +E + +  E  RL++     L 
Sbjct: 241  KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300

Query: 186  --KHQREKNEMESHIRETALEEFRLQEE--QWEAERRELQFIVQEQDTAVQNMHKKVEKL 241
              +  R   +    +RE A+   +L+ E  +++    +++F              +VE+L
Sbjct: 301  DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEF-----------YKARVEEL 349

Query: 242  ETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNS 301
            + ++    +       +LE +  R ++L  E E   L+++    ++E ER   ++ K   
Sbjct: 350  KEDNQVLLETKTMLEDQLEGTRARSDKLH-ELEKENLQLKAKLHDMEMER--DMDRKKIE 406

Query: 302  EIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQE-SFAKLNLL 360
            E+++  +  LE A +           +LE I    +  E+  +   H   E + ++L  L
Sbjct: 407  ELMEENM-TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL 465

Query: 361  EKEYFSKNKKLNE------DIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLV 414
            E E  S  K + E       +E     I+ + K  Q   K    L+ E+V  K+     +
Sbjct: 466  EMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS----L 521

Query: 415  ETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASN 474
            + C+N  K+L                  K+K         +E LR   ++ Q K+ +  N
Sbjct: 522  QNCQNLSKDL-----------------MKEK---AQLEKTIETLREN-SERQIKILEQEN 560

Query: 475  EEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNV 534
            E      L+ T   +   ++   E + K  D+ KE   LH    +  + +S ++ E + +
Sbjct: 561  E-----HLNQTVSSLRQRSQISAEARVK--DIEKENKILHESIKETSSKLSKIEFEKRQI 613

Query: 535  ---LHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGML 591
               L  ++++  +A + E+EL  L +  ++  ++K+T L                     
Sbjct: 614  KKELEHYKEKGERAEELENELHHLEKE-NELLQKKITNL--------------------- 651

Query: 592  DKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAE 651
             K +  ++ A+ QEN     ++L R N K++      KN +  +  L++       +  E
Sbjct: 652  -KITCEKIEALEQEN-----SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705

Query: 652  QIKAQES--CWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLE 709
              +  ES  C   +  +L+L+  EL  E +++ +K  E+ + + +K   +E S++ L +E
Sbjct: 706  LRRNVESLKCASMKMAQLQLENKELESE-KEQLKKGLELLKASFKKTERLEVSYQGLDIE 764

Query: 710  NSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEI 769
            N   +K L  + ++              +  L S    L  +   LQ+ +   ++    +
Sbjct: 765  NQRLQKTLENSNKK--------------IQQLESELQDLEMENQTLQKNLEELKISSKRL 810

Query: 770  RTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVI--AVLAANRLKI--LGQSCASLF 825
              L +   ++E++  +  K KK+  K   R+ ++  I    L  N +KI  L +   +L 
Sbjct: 811  EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLS 870

Query: 826  TWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQD 885
              +  +KE    L          +  K  KE ++    +   T   L   ++S   + Q 
Sbjct: 871  KEIGIYKESCVRL---------KELEKENKELVK-RATIDIKTLVTLREDLVSEKLKTQQ 920

Query: 886  VIGKADPNSRICGHLLIGAAKNSFAKL---MDKISLVMECIPLHSSRSITYVEKDSLVQR 942
            +                    N   KL   ++KI L  E + LH  +S      DS  + 
Sbjct: 921  M-------------------NNDLEKLTHELEKIGLNKERL-LHDEQS----TDDSRYKL 956

Query: 943  LAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKR 1002
            L   L                 + KS    +++I     RL  +    + LR E+   K+
Sbjct: 957  LESKLEST--------------LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK 1002

Query: 1003 SVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACE-----------ELNNALLREE- 1050
            +   +K+  D+ + +Q       +      E  E+  E           E NNA L+ E 
Sbjct: 1003 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1062

Query: 1051 -----------------QAQML-LNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLS 1092
                             QAQ+L L  Q   LQE N  L+  +++   +N TL     SL 
Sbjct: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1122

Query: 1093 EAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENI---HDAESAL--RMAAKDKECVANH 1146
                +L  +  SL   N  + +  +D + L +++   H+    L  R A++ +  ++ H
Sbjct: 1123 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKH 1181



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 234/1187 (19%), Positives = 460/1187 (38%), Gaps = 172/1187 (14%)

Query: 57   NAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEE-RLAEAHRIQEK 115
            + ELA  +++I +LR E+E  E   Q L+    + + E  L R   E   L    R    
Sbjct: 250  SVELADAKAKIRRLRQELE--EKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARM 307

Query: 116  LCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSR 175
               +   L+ K    +K  ++   ++KE      HD+E     ++    +  +L++ K+ 
Sbjct: 308  YRDELDALREKAVRVDK-LESEVSRYKERL----HDIEFYKARVEELKEDNQVLLETKTM 362

Query: 176  LEKTLQ------EALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDT 229
            LE  L+      + L + ++E  ++++ + +  +E         + +R++++ +++E  T
Sbjct: 363  LEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER--------DMDRKKIEELMEENMT 414

Query: 230  AVQNMHKKVEKLETEHMDCSDLLRRQTSEL-------------EFSTQREERLRKEFEAT 276
                M +K    E+ H+        +TSEL             E ++ R  +L  E ++ 
Sbjct: 415  L--EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472

Query: 277  TLRVRKLE---ENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIK 333
            T  V +L    +++E   +  L+ +  ++ +  ++  LE  +  EK S        + + 
Sbjct: 473  TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532

Query: 334  NEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLN--------------EDIEEQK 379
             E  ++E   E  + N++    ++ +LE+E    N+ ++              +DIE++ 
Sbjct: 533  KEKAQLEKTIETLRENSER---QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589

Query: 380  KVI-------------IDLSKRL------QYNEKS--CSELQEELVMAKKHQAFLVETCE 418
            K++             I+  KR        Y EK     EL+ EL   +K    L    +
Sbjct: 590  KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL----Q 645

Query: 419  NNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKA 478
              +  L+   +      Q  S + ++  K          L++TL  ++N      + EK 
Sbjct: 646  KKITNLKITCEKIEALEQENSELERENRK----------LKKTLDSFKNLTFQLESLEKE 695

Query: 479  CNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHT-----------------KCADRE 521
             ++LD    ++  + +++K    K+A +  E   L +                 K    E
Sbjct: 696  NSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE 755

Query: 522  ALISTLKVELQNVLHCWEKEKAQAAQSESELQKL---SQAFHKDAEE------KLTFLHT 572
                 L +E Q +    E    +  Q ESELQ L   +Q   K+ EE      +L  L  
Sbjct: 756  VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEK 815

Query: 573  LYQHLVAGCVLIKQPEGMLDKFS-----WSELCAVLQENVDALIADLNRANEKIRHLEYI 627
              + L      +++ +  L+K +      +E+     E  +  I +L + N+ +     I
Sbjct: 816  ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGI 875

Query: 628  CKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQE 687
             K     ++EL++  ++   +    IK   +       E +L+  ++  +++K   + ++
Sbjct: 876  YKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE-KLKTQQMNNDLEKLTHELEK 934

Query: 688  IAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCA 747
            I   N E+L H E+S      ++S +K L S+ +      L        AL      S  
Sbjct: 935  IG-LNKERLLHDEQS-----TDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 988

Query: 748  LSTQ-RDFLQEQVNTFELFKL--EIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKG 804
             + Q R  L+     +E  K   +   + Q+   +  +  +  +  ++T + L+++  + 
Sbjct: 989  YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1048

Query: 805  VIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQAL 864
            +        L+   Q+  +    +E+    +   +   + Q      + Q   L+   A 
Sbjct: 1049 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSL--QEQNTTLQTQNAK 1106

Query: 865  SWLTSSDLLAAIISSMAE-----LQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLV 919
              + +S L +   S M +     +Q    + +  S I     + +  +S  K  +K+ L 
Sbjct: 1107 LQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL- 1165

Query: 920  MECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGF 979
                 LH  ++  Y   +SL+ +  HG  K     L+     H  +      L KQ    
Sbjct: 1166 -----LHERQASEY---ESLISK--HGTLKSAHKNLEVE---HRDLEDRYNQLLKQKGQL 1212

Query: 980  TQRLHAAEVERRSLRLEVTEFKRSVNEMKK---ELDKAQGLQMQL--------NEFKQSK 1028
                   +VE+  + LE    +    E KK   E D+      QL         + K  K
Sbjct: 1213 EDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLK 1272

Query: 1029 -LITHEKFESACEELNNALLREEQAQM-----LLNEQAQQLQELNYKLELHSSEEADKNQ 1082
             L+ + K E    E   + L+E+  Q+      LN Q + L +L   LE  +    D+ Q
Sbjct: 1273 SLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQ 1332

Query: 1083 TLGEAVKSLSEAKMELRRK-DQSLRQLNRHLTQLEQDKRRLEENIHD 1128
            TL    ++L E  ME +       RQ    L +L + K +LEE I D
Sbjct: 1333 TLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1379



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 104/513 (20%), Positives = 220/513 (42%), Gaps = 43/513 (8%)

Query: 12   TQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLR 71
            T  L+   L+ +++L +E     TD+ R KL    + KLE T K + E+   E +IA L 
Sbjct: 929  THELEKIGLNKERLLHDEQS---TDDSRYKL---LESKLESTLKKSLEIK--EEKIAALE 980

Query: 72   SEVEKGEALRQSLEYDLAVARKE-AGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNET 130
            + +E+     Q L  +L   +K    L +R  EER+ ++          +  +  + N+ 
Sbjct: 981  ARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS----------SPPISGEDNKW 1030

Query: 131  EKAFQ-TSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQR 189
            E+  Q T+++  K + R  E  +E  +  +Q   +     +K+       LQ  +   QR
Sbjct: 1031 ERESQETTRELLKVKDRLIE--VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR 1088

Query: 190  EKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQE-----QDTAVQNMHKKVEKLETE 244
            +   ++        +  +LQ E      +    + Q      Q ++++N ++ V K   +
Sbjct: 1089 QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERED 1148

Query: 245  HMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEII 304
                 D L +   +LE   +R+    +   +    ++   +N+E E    LE ++N  + 
Sbjct: 1149 LKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR-DLEDRYNQLLK 1207

Query: 305  QL-RIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKE 363
            Q  ++ DLE  L+VE+        + E +  E+K++    +R  H   +   +  +L+ +
Sbjct: 1208 QKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD 1267

Query: 364  YFSKNKKLNEDIEEQKKVIIDLSK-RLQYNEKSCSELQEELVMAKKHQAFLVETCENNV- 421
            + +    LN    EQ ++  + SK + QY +   +  +        +Q  L+   + N+ 
Sbjct: 1268 HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTK------LNNQCELLSQLKGNLE 1321

Query: 422  KELESILDSF-TVSGQWTSGIHKDKDKPPSFSV----VLERLRRTLTDYQNKLEDASNEE 476
            +E   +LD   T+  Q  + + ++ +    F V     +++L   L   + KLE+   ++
Sbjct: 1322 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNE-LRRQKEKLEEKIMDQ 1380

Query: 477  KACNELDSTKQKIDSHTKNIKELQDKLADVNKE 509
                +    +++ +  T  +++L     D+N+E
Sbjct: 1381 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRE 1413



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 138/670 (20%), Positives = 259/670 (38%), Gaps = 88/670 (13%)

Query: 512  HLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLH 571
            HL  + AD +A I  L+ EL+         K +  Q E EL++L Q       E +  L 
Sbjct: 248  HLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ-------ENMNLLS 300

Query: 572  TLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQE--NVDALIADLNRANEKIRHLEYICK 629
                            +    +    EL A+ ++   VD L ++++R  E++  +E+  K
Sbjct: 301  ----------------DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFY-K 343

Query: 630  NKSDTMRELQQTQEDTFTKVAEQI---KAQESCWHRQKKE---LELQYSELFLEVQKRAQ 683
             + + ++E  Q   +T T + +Q+   +A+    H  +KE   L+ +  ++ +E     +
Sbjct: 344  ARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRK 403

Query: 684  KFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYS 743
            K +E+ E+NM     +E + +Q + E+ H    L Q  R      A    +   +  L S
Sbjct: 404  KIEELMEENMT----LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTS 459

Query: 744  -RSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFR 802
             R   L  +    Q    T E  +  + ++    S + + ++E  ++ KK       I +
Sbjct: 460  SRLLKLEMEN---QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ 516

Query: 803  KGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQ 862
            +        N  K L +  A L   +E+ +E     +   E +++H              
Sbjct: 517  EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEH-------------- 562

Query: 863  ALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMEC 922
             L+   SS    + IS+ A ++D+  +          +L  + K + +KL  KI      
Sbjct: 563  -LNQTVSSLRQRSQISAEARVKDIEKE--------NKILHESIKETSSKL-SKIEFEKRQ 612

Query: 923  IPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTA------------ 970
            I           E+   ++   H L K N L  K      +   K  A            
Sbjct: 613  IKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELEREN 672

Query: 971  -SLQKQILGF---TQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQ 1026
              L+K +  F   T +L + E E   L  E  E +R+V  +K    K   LQ++  E + 
Sbjct: 673  RKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELES 732

Query: 1027 SKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGE 1086
             K    E+ +   E L  +  + E+ ++      Q L   N +L+        K Q L  
Sbjct: 733  EK----EQLKKGLELLKASFKKTERLEV----SYQGLDIENQRLQKTLENSNKKIQQLES 784

Query: 1087 AVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANH 1146
             ++ L      L++  + L+  ++ L QLE++ + LE+     E   +   K+ + +   
Sbjct: 785  ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844

Query: 1147 MRAVENTLHK 1156
                + TL +
Sbjct: 845  AEIKDTTLEE 854



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 73/337 (21%), Positives = 143/337 (42%), Gaps = 38/337 (11%)

Query: 3    LNTSSNTGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELAS 62
            LN+ S +   Q  ++         +NE+ +   ++L+       K+  ++   H  + + 
Sbjct: 1114 LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1173

Query: 63   YESQIAK---LRSEVEKGEALRQSLE--YDLAVARKEAGLGRRAAEERLAEAHRIQEKLC 117
            YES I+K   L+S  +  E   + LE  Y+  + +K    G+    E++ +    QEK+ 
Sbjct: 1174 YESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK----GQLEDLEKMLKVE--QEKML 1227

Query: 118  AQN-------SELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLM 170
             +N       +E +    E ++   T  Q  K E    + D +   +++ N   E   L 
Sbjct: 1228 LENKNHETVAAEYKKLCGENDRLNHTYSQLLK-ETEVLQTDHKNLKSLLNNSKLEQTRLE 1286

Query: 171  KEKSRLEKTLQEALEKHQREKNEME--SHIRETALEEFRLQEEQWEAERRELQFIVQEQD 228
             E S+L++  Q+      +  N+ E  S ++    EE R   +Q +        ++Q + 
Sbjct: 1287 AEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQT------LMLQNRT 1340

Query: 229  TAVQNMHKK--VEKLETEHMDCSDLLRRQTSELEFSTQREERL------RKEFEATTLRV 280
               QNM  K      + +++D  + LRRQ  +LE     + +       R+     TL++
Sbjct: 1341 LLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKM 1400

Query: 281  RKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQV 317
            RKL   I++++  + E + +  +   R    EG LQ+
Sbjct: 1401 RKL---IKSKKDINRERQKSLTLTPTRSDSSEGFLQL 1434



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 73/328 (22%), Positives = 134/328 (40%), Gaps = 49/328 (14%)

Query: 990  RRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLRE 1049
            R+ L +E+ + K  +  +++EL++      QL + KQ       + +   +E  N L   
Sbjct: 246  RQHLSVELADAKAKIRRLRQELEEKTE---QLLDCKQELEQMEIELKRLQQENMNLLSDA 302

Query: 1050 EQAQML------LNEQAQQLQELN-----YKLELHSSE-EADKNQTLGEAVKSLSEAKME 1097
              A+M       L E+A ++ +L      YK  LH  E    + + L E  + L E K  
Sbjct: 303  RSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM 362

Query: 1098 LRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKV 1157
            L  + +  R  +  L +LE++  +L+  +HD E    M  K  E +      +E    + 
Sbjct: 363  LEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQS 422

Query: 1158 RDQ-ISLSW--SAASRNDFTLQLPKLHL-----ETFAMEGLK---GGPEVVACQAMIKSF 1206
             D+ + L W     SR     + P+  L     E  +   LK       +      +++ 
Sbjct: 423  MDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTT 482

Query: 1207 MDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTACLRENASLQSIGSRDHSNLSIPSRA 1266
            +D  +  +++I+ +EKE       +  L++E+    ++E  SLQ+       NLS     
Sbjct: 483  VDSVEGNASKILKMEKENQRLSKKVEILENEI----VQEKQSLQNC-----QNLS----- 528

Query: 1267 PLPADTTGIGDFLPLKAELDTTYTFLKE 1294
                      D +  KA+L+ T   L+E
Sbjct: 529  ---------KDLMKEKAQLEKTIETLRE 547



 Score = 39.7 bits (91), Expect = 0.019
 Identities = 55/251 (21%), Positives = 109/251 (43%), Gaps = 39/251 (15%)

Query: 972  LQKQILGFTQRLHAAEVERRSLRLEVTEF-----------KRSVNEM------------K 1008
            L+K+ L    +LH  E+ER   R ++ E            K+S++E              
Sbjct: 380  LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT 439

Query: 1009 KELDKA--QGLQMQLNEFKQSKLIT----HEKFESACEELNNALLREEQAQMLLNEQAQQ 1062
             EL +A  + L  ++NE   S+L+     ++      EEL   +   E     + +  ++
Sbjct: 440  SELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKE 499

Query: 1063 LQELNYKLELHSSEEADKNQTLGEAV---KSLSEAKMELRRKDQSLRQLN-RHLTQLEQD 1118
             Q L+ K+E+  +E   + Q+L       K L + K +L +  ++LR+ + R +  LEQ+
Sbjct: 500  NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQE 559

Query: 1119 KRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLP 1178
                 E+++   S+LR   + +      ++ +E     + + I  + S  S+ +F  +  
Sbjct: 560  N----EHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613

Query: 1179 KLHLETFAMEG 1189
            K  LE +  +G
Sbjct: 614  KKELEHYKEKG 624


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  105 bits (261), Expect = 4e-22
 Identities = 226/1181 (19%), Positives = 475/1181 (40%), Gaps = 182/1181 (15%)

Query: 46   KKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEER 105
            KKE +++ T  +      E +  KL+ E +K ++   S E  ++  R E   G +     
Sbjct: 227  KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286

Query: 106  LAEAHRIQ---EKLCAQNSELQAKTNETEKAFQTSQQKWKEEC---RRFEHDLEERDNMI 159
            + E  +++    +L  +N  L     + E+ +   ++K  EE    +  +  L ++D   
Sbjct: 287  VQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346

Query: 160  QNCNREYDLLMKEKSRLEKTLQ---EALEKHQREKNEMESHIRETALEEFRLQEEQWEAE 216
            Q              R+   L    EA +K + E +E+E+  +    E  +LQ+++ E E
Sbjct: 347  QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE 406

Query: 217  RRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEAT 276
            +  LQ       + +  +H K+  LETE     +   R   + + S+++     ++    
Sbjct: 407  QHGLQL-----QSEINQLHSKL--LETER-QLGEAHGRLKEQRQLSSEKLMDKEQQVADL 458

Query: 277  TLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEF 336
             L++ +LEE ++ +     E +   +  + + ++ +   Q   A   EA  DLE +  + 
Sbjct: 459  QLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQI 518

Query: 337  KEVESAYEREKHNAQESFAKLNLLEKE----------------YFSKNKKLNEDIEEQKK 380
             + +   +  +   Q+S   ++LLEKE                  ++ ++ N  ++EQ  
Sbjct: 519  GDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ-- 576

Query: 381  VIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSG 440
             +  L+++L+   +S  + QE L    + Q   +   ++ V  LE      T   +  S 
Sbjct: 577  -VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE------TSVNELNSQ 629

Query: 441  IHKDKDKPPSFSVVLERLRRTL-----------TDYQNKLEDASNE--------EKACNE 481
            +++ K+K     + ++     L            D QN L+ A N          K   +
Sbjct: 630  LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689

Query: 482  LDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKE 541
            LD    K+    ++  +L+  L +  ++   L  K  + E  I  L+ +   V       
Sbjct: 690  LDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV------- 742

Query: 542  KAQAAQSESELQKLSQAFHKDAEEKLTFLH---TLYQHLVAGCVLIKQP-----EGMLDK 593
            KA   Q+  +LQ+  Q  + D E + T L     + + +V+   L  Q      E +  K
Sbjct: 743  KASKEQALQDLQQQRQ-LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801

Query: 594  FS-WSELCAVLQENVDALIADL--------NRANEKIRHLEYICKNKSDTMRELQQTQED 644
             +   E   +L+++ + L  +         NR    +  L+ +   K   M EL  T +D
Sbjct: 802  LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL-STVKD 860

Query: 645  TFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHE 704
              +KV++ +K  +S + ++ ++ +    +L    ++   + Q   E  +++   ++KS E
Sbjct: 861  KLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLE 920

Query: 705  QLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFEL 764
            +   E SH  KL   + +EQ+               + +++     +++  Q Q N  EL
Sbjct: 921  K-EKEASHQLKLELNSMQEQL---------------IQAQNTLKQNEKEEQQLQGNINEL 964

Query: 765  FKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLK-ILGQSCAS 823
             +          S+ ++KKQ EA       +G ++      IAVL    L+  L Q    
Sbjct: 965  KQ----------SSEQKKKQIEA------LQGELK------IAVLQKTELENKLQQQLTQ 1002

Query: 824  LFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAEL 883
                + + KE I +L        ++ + K Q E  + LQ+  +   S+LLA     +  +
Sbjct: 1003 AAQELAAEKEKISVL--------QNNYEKSQ-ETFKQLQSDFYGRESELLAT-RQDLKSV 1052

Query: 884  QDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKDSLVQRL 943
            ++ +  A     I     IG       KL+ ++      +   S++      K+  +Q  
Sbjct: 1053 EEKLSLAQ-EDLISNRNQIGNQN----KLIQELKTAKATLEQDSAK------KEQQLQER 1101

Query: 944  AHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRS 1003
               L                 I K  +  +K+++    +L  AE+E    R E     + 
Sbjct: 1102 CKALQ---------------DIQKEKSLKEKELVNEKSKL--AEIEEIKCRQE-----KE 1139

Query: 1004 VNEMKKEL--DKAQGLQMQLNEFKQSKLITHEKFE--SACEELNNALLREEQAQMLLNEQ 1059
            + ++ +EL   K + ++   N     +L+  +K E     + L  A+ +E++ Q +L +Q
Sbjct: 1140 ITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQ 1199

Query: 1060 AQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDK 1119
             ++ +E     EL   E  +K   L   +K   E ++ +++ +++  +L   +T L ++ 
Sbjct: 1200 VKKEEE-----EL-KKEFIEKEAKLHSEIK---EKEVGMKKHEENEAKLTMQITALNENL 1250

Query: 1120 RRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQ 1160
              +++    ++  +    K  + +   +  +E T+   +D+
Sbjct: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDE 1291



 Score =  102 bits (255), Expect = 2e-21
 Identities = 241/1226 (19%), Positives = 489/1226 (39%), Gaps = 156/1226 (12%)

Query: 69   KLRSEVEKGEALRQS-LEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKT 127
            +L+ E+EK + L+Q   + D  V    A L  ++ E++L EA      +       + K 
Sbjct: 108  ELKKELEKYQGLQQQEAKPDGLVTDSSAEL--QSLEQQLEEAQTENFNIKQMKDLFEQKA 165

Query: 128  NETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRL-EKTLQEALEK 186
             +        + K+ EE    E   ++   + +  N+E  ++   K+ L ++   E +  
Sbjct: 166  AQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAV 225

Query: 187  HQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHM 246
             ++E  ++++ +    LE  R + E+ + E ++LQ      +  +  +  ++ K   E  
Sbjct: 226  LKKELVQVQTLMDNMTLERER-ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVA 284

Query: 247  DCSDLLRRQTSELEFSTQR-----EERLRKEFEATTLRVRKLEENIEAE--RAAHLESKF 299
                 L++  S +   TQ+     E  L+KE + T L  +  EE++  +  +A   +   
Sbjct: 285  VYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL 344

Query: 300  NSEIIQLRIRDLEGALQ---VEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAK 356
            + + +Q R+   E +L    VE + + EA   L   K E  EVE+ Y+  K      F +
Sbjct: 345  DCQQLQSRLSASETSLHRIHVELSEKGEATQKL---KEELSEVETKYQHLK----AEFKQ 397

Query: 357  LNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNE---KSCSELQEELVMAKKHQAFL 413
            L    +E      +L  +I +    +++  ++L       K   +L  E +M K+ Q   
Sbjct: 398  LQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVAD 457

Query: 414  VETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDAS 473
            ++   + ++E   + +  T S +    + K K +      + +     L + QN LE   
Sbjct: 458  LQLKLSRLEE--QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLE--- 512

Query: 474  NEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQN 533
               +   ++    QKI +    +++ ++ ++ + KE   L+ K    E   + L  +LQ 
Sbjct: 513  ---QVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLN-QLQE 568

Query: 534  VLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDK 593
              H  ++   Q  Q   +L+  S++ HK A+E L   H   Q   A   L    + +L  
Sbjct: 569  KNHTLQE---QVTQLTEKLKNQSES-HKQAQENL---HDQVQEQKAH--LRAAQDRVLS- 618

Query: 594  FSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQI 653
                     L+ +V+ L + LN + EK+  L+   K K++ +   +  +      +   +
Sbjct: 619  ---------LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHL 669

Query: 654  KAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHF 713
               ++    +++EL    +++  ++ +   K Q+  E   +  +H+++  E+ +      
Sbjct: 670  DTAQNALQDKQQEL----NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725

Query: 714  KKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLA 773
            ++L  Q ++ +   L   A    AL  L              Q Q+NT     LE+R   
Sbjct: 726  EELEGQIKKLEADSLEVKASKEQALQDLQQ------------QRQLNT----DLELRA-- 767

Query: 774  QALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKE 833
                  E  KQ E  M+K+               ++++ RL +  +S A     +ES K+
Sbjct: 768  -----TELSKQLE--MEKE---------------IVSSTRLDLQKKSEA-----LESIKQ 800

Query: 834  GIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPN 893
             +     T + ++K       K+    L   + +   +L   I +++ ELQ V  + +  
Sbjct: 801  KL-----TKQEEEKQIL----KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKE-- 849

Query: 894  SRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSR--------SITYVEKDSLVQRLAH 945
                      A     + + DK+S V + +    S             ++ +   + L H
Sbjct: 850  ----------ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899

Query: 946  GLH--KVNTLALKYGLRGHVPITKSTA--------SLQKQILGFTQRLHAAEVERRSLRL 995
             L     NTL  +  L+  +   K  +        S+Q+Q++     L   E E + L+ 
Sbjct: 900  QLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQG 959

Query: 996  EVTEFKRSVNEMKKELDKAQG------LQMQLNEFKQSKLITHEKFESACEELNNALLRE 1049
             + E K+S  + KK+++  QG      LQ    E K  + +T    E A E+   ++L+ 
Sbjct: 960  NINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN 1019

Query: 1050 EQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLN 1109
               +    E  +QLQ   Y  E   SE     Q L    + LS A+ +L      +   N
Sbjct: 1020 NYEKS--QETFKQLQSDFYGRE---SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQN 1074

Query: 1110 RHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAAS 1169
            + + +L+  K  LE++    E  L+   K  + +       E  L   + +++       
Sbjct: 1075 KLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKC 1134

Query: 1170 RNDFTLQLPKLHLETFAMEGLKGGPEVV-ACQAMIKSFMDVYQLASTRIMTLEKEMTSH- 1227
            R +  +      L++  +E +K    +  A Q +I+  +++   A +    +E+E  +  
Sbjct: 1135 RQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQ 1194

Query: 1228 --RSHIAALKSELHTACLRENASLQS 1251
              +  +   + EL    + + A L S
Sbjct: 1195 ILKDQVKKEEEELKKEFIEKEAKLHS 1220



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 136/736 (18%), Positives = 309/736 (41%), Gaps = 78/736 (10%)

Query: 12   TQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITT---KHNAELASYESQIA 68
            T++LK  S   KQ  +N    D     +  L  A+   L + T   + N++L   + +++
Sbjct: 581  TEKLKNQSESHKQAQENLH--DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVS 638

Query: 69   KLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTN 128
            +L  +++    L  S E      R +       A+  L +  +   K+  Q  ++ AK  
Sbjct: 639  QLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ 698

Query: 129  ETEK---AFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALE 185
            + ++     ++  +++KE+    E   EE +  I+    +    ++ K+  E+ LQ+  +
Sbjct: 699  DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS---LEVKASKEQALQDLQQ 755

Query: 186  KHQREKN------------EMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQN 233
            + Q   +            EME  I  +   + + + E  E+ +++L    +E+    Q+
Sbjct: 756  QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD 815

Query: 234  MHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAA 293
                 ++ + +H + ++ ++   +EL+     +E L  E      ++ K+ ++++  ++ 
Sbjct: 816  FETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKS- 874

Query: 294  HLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQES 353
              E +  ++  +  I DLE      K  + +    +E    E KE++ + E+EK  + + 
Sbjct: 875  --EFEKENQKGKAAILDLEKTC---KELKHQLQVQMENTLKEQKELKKSLEKEKEASHQL 929

Query: 354  FAKLNLLEKEYFSKNKKLNEDIEEQKKV---IIDLSKRLQYNEKSCSELQEELVMAKKHQ 410
              +LN ++++       L ++ +E++++   I +L +  +  +K    LQ EL +A   +
Sbjct: 930  KLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQK 989

Query: 411  AFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLE 470
                        ELE+ L              K+K      SV+     ++   ++    
Sbjct: 990  T-----------ELENKLQQQLTQAAQELAAEKEK-----ISVLQNNYEKSQETFKQLQS 1033

Query: 471  DASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVE 530
            D    E   +EL +T+Q       ++K +++KL+   ++L     +  ++  LI  LK  
Sbjct: 1034 DFYGRE---SELLATRQ-------DLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTA 1083

Query: 531  LQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGM 590
               +    E++ A+  Q   E  K  Q   K+   K   L      L     +  + E  
Sbjct: 1084 KATL----EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1139

Query: 591  LDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVA 650
            + K +  EL +   E++   I +L  A + +   +   + K+D+++   + ++     + 
Sbjct: 1140 ITKLN-EELKSHKLESIKE-ITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILK 1197

Query: 651  EQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLEN 710
            +Q+K +E       +EL+ ++      ++K A+   EI EK +    H E++  +L ++ 
Sbjct: 1198 DQVKKEE-------EELKKEF------IEKEAKLHSEIKEKEVGMKKH-EENEAKLTMQI 1243

Query: 711  SHFKKLLSQTQREQMS 726
            +   + L   ++E  S
Sbjct: 1244 TALNENLGTVKKEWQS 1259



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 132/656 (20%), Positives = 283/656 (43%), Gaps = 80/656 (12%)

Query: 5    TSSNTGDTQRLKIASLDVK-------QILKNETELDITDNLRK-KLHWAKKEKLEITTKH 56
            T    G  ++L+  SL+VK       Q L+ + +L+    LR  +L    + + EI +  
Sbjct: 725  TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784

Query: 57   NAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERL----AEAHRI 112
              +L      +  ++ ++ K E  +Q L+ D     +E  +       R+     E  ++
Sbjct: 785  RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKV 844

Query: 113  Q---EKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLL 169
            +   E L  + S ++ K ++   + + S+ ++++E ++ +  + + +   +    +  + 
Sbjct: 845  KMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQ 904

Query: 170  MKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQE--EQWEAERRELQFIVQEQ 227
            M+   + +K L+++LEK +   ++++  +     +  + Q   +Q E E ++LQ  + E 
Sbjct: 905  MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINEL 964

Query: 228  DTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQRE-ERLRKEFEATTLRVRKLEEN 286
              + +   K++E L+ E      +   Q +ELE   Q++  +  +E  A   ++  L+ N
Sbjct: 965  KQSSEQKKKQIEALQGE----LKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020

Query: 287  IEA--ERAAHLESKF---NSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVES 341
             E   E    L+S F    SE++  R +DL+   +    +Q + +++   I N+ K ++ 
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATR-QDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE 1079

Query: 342  AYEREKHNAQESFAKLNLLEK-----EYFSKNKKLNE-DIEEQKKVIIDLSKRLQYNEKS 395
                +    Q+S  K   L++     +   K K L E ++  +K  + ++ +     EK 
Sbjct: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1139

Query: 396  CSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVL 455
             ++L EEL   K H+         ++KE+ ++ D+  +  Q    +   + K  S    +
Sbjct: 1140 ITKLNEEL---KSHKL-------ESIKEITNLKDAKQLLIQQKLEL---QGKADSLKAAV 1186

Query: 456  ERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHT 515
            E+ +R     Q  L+D   +E    E +  K+ I+   K   E+++K   + K       
Sbjct: 1187 EQEKRN----QQILKDQVKKE----EEELKKEFIEKEAKLHSEIKEKEVGMKKH------ 1232

Query: 516  KCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQ 575
               + EA ++     L   L   +KE   + +  SEL+K +     D   ++  L    Q
Sbjct: 1233 --EENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD----DLRGEIAVLEATVQ 1286

Query: 576  H-------LVAGCVLIKQPEGMLDKFSWS--ELCAVLQENVDALIADLNRANEKIR 622
            +       L+  C+   + EG ++K      EL   L +N  A + +L R N+ ++
Sbjct: 1287 NNQDERRALLERCL---KGEGEIEKLQTKVLELQRKL-DNTTAAVQELGRENQSLQ 1338



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 105/522 (20%), Positives = 230/522 (44%), Gaps = 70/522 (13%)

Query: 11   DTQRLKIASLDVKQI---LKNETELDITDNLRKKLHWAKKEKLEITTKHNA--ELASYES 65
            + Q+ K A LD+++    LK++ ++ + + L+++    K  + E    H    EL S + 
Sbjct: 879  ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938

Query: 66   QIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEA-----------HRIQE 114
            Q+ + ++ +++ E   Q L+ ++   ++ +   ++  E    E            +++Q+
Sbjct: 939  QLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ 998

Query: 115  KLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKS 174
            +L     EL A+  E     Q + +K +E  ++ + D   R++ +    ++    +K   
Sbjct: 999  QLTQAAQELAAE-KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD----LKSVE 1053

Query: 175  RLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNM 234
                  QE L  ++ +       I+E    +  L+++  + E++     +QE+  A+Q++
Sbjct: 1054 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQ-----LQERCKALQDI 1108

Query: 235  HKKVEKLETEHMDCSDLLRRQTSELEFSTQRE-ERLRKEFEATTLRVRKLEENIEAERAA 293
             K+    E E ++    L  +  E++   ++E  +L +E ++  L   K   N++  +  
Sbjct: 1109 QKEKSLKEKELVNEKSKLA-EIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQL 1167

Query: 294  HLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQES 353
             ++ K     +Q +   L+ A++ EK +Q       +I+K++ K+ E   ++E     E 
Sbjct: 1168 LIQQKLE---LQGKADSLKAAVEQEKRNQ-------QILKDQVKKEEEELKKE---FIEK 1214

Query: 354  FAKLN--LLEKEYFSKNKKLNE-----DIEEQKKVIIDLSKRLQYNEKSCSELQEELVMA 406
             AKL+  + EKE   K  + NE      I    + +  + K  Q +++  SEL+++    
Sbjct: 1215 EAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDL 1274

Query: 407  KKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQ 466
            +   A L  T +NN  E  ++L+   + G+                  +E+L+  + + Q
Sbjct: 1275 RGEIAVLEATVQNNQDERRALLER-CLKGEGE----------------IEKLQTKVLELQ 1317

Query: 467  NKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNK 508
             KL+   N   A  EL    Q +    K+ + L  K A+ N+
Sbjct: 1318 RKLD---NTTAAVQELGRENQSL--QIKHTQALNRKWAEDNE 1354



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 37/131 (28%), Positives = 57/131 (43%), Gaps = 10/131 (7%)

Query: 989  ERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITH-----EKFESACEELN 1043
            E + L+  + E K    E+KKEL+K QGLQ Q  E K   L+T      +  E   EE  
Sbjct: 91   EVQDLQASLKEEKWYSEELKKELEKYQGLQQQ--EAKPDGLVTDSSAELQSLEQQLEEAQ 148

Query: 1044 NALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQ 1103
                  +Q + L  ++A QL      ++    EE    +   + V  L+E   EL ++  
Sbjct: 149  TENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTE---ELNKEAT 205

Query: 1104 SLRQLNRHLTQ 1114
             ++ L   L Q
Sbjct: 206  VIQDLKTELLQ 216


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  103 bits (258), Expect = 8e-22
 Identities = 171/784 (21%), Positives = 324/784 (41%), Gaps = 86/784 (10%)

Query: 64   ESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSEL 123
            E ++ +LR+E E+GE  RQ LE +LA  ++EA    +  +E  AE  +++ ++    +  
Sbjct: 1712 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771

Query: 124  QAKTNETEKAFQTSQQKWKEECRRFEHDLEERDN---MIQNCNREYDL----LMKEKSRL 176
                 E+    + S+Q+ + E  RF    EE      + +   R+  L      ++++  
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831

Query: 177  EKTLQE---ALEKHQREKNEMESHIRETALEEFRLQE--EQWEAERRELQFIVQEQDTAV 231
            E+ L E   A+ +  R K E E  ++E   E  RL+   E    +RR L+    +    +
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891

Query: 232  QNMHKKVEK-----LETEHMDCSDLL--RRQTSE----LEFSTQREERLRKEFEATTLRV 280
            +    ++ K     LE +     D L  RRQ  E    L+ S ++    + E E    R+
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951

Query: 281  R-KLEENIEAERAAHLESKFNSEII---QLRIRDLEGALQVEKASQAEAV----ADLEII 332
            R   E+ + ++  A LE+    ++    + R R+ E  +Q   A++ EA     A LE +
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011

Query: 333  KNEFKEVESAYEREKHNAQESFAKLNLLEK---------------EYFSKNKKLNEDIEE 377
            +    +VE A    +   QES  +L L ++                   K ++L + +++
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071

Query: 378  QKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQW 437
            ++ V+  L    +   ++  E +E  V A++  A         V+E E +  S     Q 
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA----QSRRQVEEAERLKQSAEEQAQA 2127

Query: 438  TSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIK 497
             +                E+LR+     Q     A  E+ A  +  +   +++ H K  +
Sbjct: 2128 RA----------QAQAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2175

Query: 498  ELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQ 557
            +   + A V +EL+ L  +  + +   + L  ELQ +    + E  +AA+  S++++   
Sbjct: 2176 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL----KAEATEAARQRSQVEEELF 2231

Query: 558  AFHKDAEEKLTFLHTLYQHLVA-GCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNR 616
            +     EE    L  L   + A    LI + +    +F   E  A   + V    A L+ 
Sbjct: 2232 SVRVQMEE----LSKLKARIEAENRALILRDKDNTQRFLQEE--AEKMKQVAEEAARLSV 2285

Query: 617  ANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKA-QESCWHRQKKELELQYSELF 675
            A ++   L  + +      R L +        + E+++A QE+   + + EL  Q  EL 
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKM------LKEKMQAVQEATRLKAEAELLQQQKEL- 2338

Query: 676  LEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMA 735
               Q++A++ QE  E+  ++L   E    Q  LE    ++L    + E++ L    A M+
Sbjct: 2339 --AQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKL--RVAEMS 2393

Query: 736  GALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFK 795
             A       +     Q + + E+++  EL   E  TL Q L    ++   +A+  ++   
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453

Query: 796  GLIR 799
             L R
Sbjct: 2454 ELER 2457



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 175/838 (20%), Positives = 345/838 (41%), Gaps = 117/838 (13%)

Query: 55   KHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARK-----EAGLGRRAAEERLAEA 109
            K  A  A  E ++ ++RS  E  + LR   + +L  AR+     E    RR AEER+ ++
Sbjct: 1936 KAAAGKAELELELGRIRSNAE--DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993

Query: 110  HRIQEKLCAQNS-------ELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNC 162
               +E+   Q          L+AK  E  +  + ++Q   E  R+ +   E     +Q  
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ---ESARQLQLAQEAAQKRLQAE 2050

Query: 163  NREYDLLMKEKSR-LEKTLQEALEKHQREKNEMESHIRETA-LEEFRLQEEQWEAERRE- 219
             + +   +++K + L++TLQ+      + + E E+  R     EE R+Q E+  A+ R  
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110

Query: 220  ------LQFIVQEQDTAVQNMHKKVEKLETE---------HMDCSDLLRRQTSELEFSTQ 264
                  L+   +EQ  A        EKL  E           + + L ++Q ++ E    
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2170

Query: 265  R---EERLRK----EFEATTLRVRK---------LEENI-----EAERAAHLESKFNSEI 303
            +   E+ LR+    E E TTLR++          L+E +     EA  AA   S+   E+
Sbjct: 2171 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2230

Query: 304  IQLRIRDLEGA---LQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLL 360
              +R++  E +    ++E  ++A  + D +   N  + ++   E+ K  A+E+ A+L++ 
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRALILRDKD---NTQRFLQEEAEKMKQVAEEA-ARLSVA 2286

Query: 361  EKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENN 420
             +E     +   ED+ +Q+ +   + K      +  + L+ E  + ++ +    E     
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2346

Query: 421  VKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACN 480
             ++ E +        Q              F   LE  R      Q +LE ++  E+   
Sbjct: 2347 QEDKEQMAQQLAEETQ-------------GFQRTLEAER------QRQLEMSAEAERLKL 2387

Query: 481  ELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEK 540
             +    +      ++ +  + +  ++ ++L        ++  L+ TL+++ Q   H  E+
Sbjct: 2388 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2447

Query: 541  EKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELC 600
             +   A+ E E +KL Q      E KL  L +     V    L+++ + +   F  SE  
Sbjct: 2448 LREAIAELEREKEKLQQ------EAKLLQLKSEEMQTVQQEQLLQETQALQQSFL-SEKD 2500

Query: 601  AVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCW 660
            ++LQ         + +   K+  L      K+  +RE QQ Q+    +  +++ A     
Sbjct: 2501 SLLQRE-----RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555

Query: 661  HRQKKELE----LQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKL 716
             R++ E E     +  EL    Q+R Q+ + +AE+N       ++  EQL L     +  
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN-------QRLREQLQLLEEQHRAA 2608

Query: 717  LSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDF--LQEQVNTFELFKL------E 768
            L+ ++    S +AA   +      L   +     +  F  L+ +V+   L +       E
Sbjct: 2609 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2668

Query: 769  IRTLAQALSTVEE-KKQEEAK---MKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCA 822
            ++ LAQ  +TV+E  ++E+ +     + +  GL+       ++V AA + ++L    A
Sbjct: 2669 LQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTA 2726



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 235/1168 (20%), Positives = 491/1168 (42%), Gaps = 144/1168 (12%)

Query: 11   DTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKL 70
            + +RL+    D  Q  K + E+++   ++ +   A++++  +       L + E++    
Sbjct: 1495 EAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1553

Query: 71   RSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNET 130
            ++EVE+   ++ +LE     A  E    R +  E+ A+  R  ++     ++L+      
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR------ 1607

Query: 131  EKAFQTSQQKWKEECRRFEHDLE-ERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQR 189
            E+A + +QQ+ + E  R E + E ER  +  N      L  +E ++ +K+L +A  + Q+
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQK 1666

Query: 190  EKNEMESHIR----ETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEH 245
            E+ E E+  R    E A+ +  L E++ E +R+  +   Q++  A Q + +   + ETE 
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL--RAETEQ 1724

Query: 246  MDCS-DLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERA-AHLESKFNSEI 303
             +    LL  + + L+       + R+E EA   +VR   E + A +A A  ES+  SE 
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1784

Query: 304  IQLRIRDLEGALQ--VEKASQAEAVADLEIIKNEFKEVESAYER--------EKHNA--- 350
             + R+    G  +   E+A++  A+A+    + +  E ++A +R        EK  A   
Sbjct: 1785 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844

Query: 351  ---QESFAKLNLLEKEYFSKN-KKLNEDIEEQKKVIIDLSKRLQYN-EKSCSELQEELVM 405
                ++ A++ L EKE  ++  ++L ED   Q++ + + + + + + E+  ++L++    
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904

Query: 406  AKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDY 465
              + Q  LVE      +++E  + +   S        K         + L R+R    D 
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKAS------FEKAAAGKAELELELGRIRSNAEDT 1958

Query: 466  QNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREAL-- 523
                E A  E     +L + +++        +E +++   V K L+        R+A   
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEER------RRREAEER---VQKSLAAEEEAARQRKAALE 2009

Query: 524  -ISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHK--DAEEKLTFLHTLYQHLVAG 580
             +  LK +++      E+ + ++A+   +LQ   +A  K   AEEK      + Q     
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESAR---QLQLAQEAAQKRLQAEEK-AHAFAVQQKEQEL 2065

Query: 581  CVLIKQPEGMLDKFSWSELCA--VLQENVDALIADLNRANEKIRHLEYICKNKSDTMREL 638
               ++Q + +LD+       A    +E  +A +     A +  R +E   + K     + 
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125

Query: 639  Q-----QTQEDTFTKVAEQIKA------QESCWHRQKKELELQYSELFLE--VQKRAQKF 685
            Q     Q   +   K AEQ  A      Q +   +Q  + E++  + F E  ++++AQ  
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185

Query: 686  QEIA------EKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALY 739
            QE+       E+   + N +++  ++L  E +   +  SQ + E  S+      ++    
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245

Query: 740  PLYSRSCAL------STQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKT 793
             + + + AL      +TQR FLQE+         +++ +A+  + +    QE A++++  
Sbjct: 2246 RIEAENRALILRDKDNTQR-FLQEEAE-------KMKQVAEEAARLSVAAQEAARLRQLA 2297

Query: 794  FKGLI-------RIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQD 846
             + L        ++ ++ + AV  A RLK    + A L    +   +     +   + Q 
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLK----AEAELLQQQKELAQEQARRLQEDKEQM 2353

Query: 847  KHKFPKHQKEQLRCLQA-----LSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLL 901
              +  +  +   R L+A     L     ++ L   ++ M+  Q    +A+ +++      
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQ------ 2404

Query: 902  IGAAKNSFAKLMDKISLVMECIPLHSSRSITYVE--------KDSLVQRLAHGLHKVNTL 953
                   F K  ++I   +    L +   +T V+         D   +RL   + ++   
Sbjct: 2405 ------RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2458

Query: 954  ALKYGLRGHVPITKSTASL---QKQILGFTQRLHAAEVERRSLRLEVTEF----KRSVNE 1006
              K      +   KS       Q+Q+L  TQ L  + +  +   L+   F    K  + +
Sbjct: 2459 KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2518

Query: 1007 M-KKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQE 1065
            + + E+ KAQ L+ +    +Q      ++  ++ EE   A  R+ +A+  +  + ++LQ+
Sbjct: 2519 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEELQQ 2575

Query: 1066 LNYKLELHSSEEADKNQTLGEAVKSLSE 1093
            L  +        A++NQ L E ++ L E
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEE 2603



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 246/1251 (19%), Positives = 495/1251 (39%), Gaps = 165/1251 (13%)

Query: 3    LNTSSNTGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELAS 62
            L  SS      + + A    +  L+ E E+ +   +R +L   ++++     +  A  A 
Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRV---VRLQLEATERQRGGAEGELQALRAR 1481

Query: 63   YESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSE 122
             E   A+ R   E+ E LR+ ++ D +  +++A +   +  +  AEA R +++      E
Sbjct: 1482 AEEAEAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540

Query: 123  LQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKS-RLEKTLQ 181
            L+ +  E E+  + ++    E  R+ +  LE      +   +       EK+ +LE++LQ
Sbjct: 1541 LRLQAEEAERRLRQAEV---ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597

Query: 182  E-----ALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRE-LQFIVQEQDTAVQNMH 235
            E     A  + + E+   +    E A EE   + E+W+ +  E L+  +Q ++ A Q   
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ--- 1654

Query: 236  KKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKL-EENIE-----A 289
            K + + E E         +Q  E E    RE R R + E   +R R+L E+ +E     A
Sbjct: 1655 KSLAQAEAE---------KQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQLA 1701

Query: 290  ERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHN 349
            E  A        E+I+LR        + E+  Q   + + E+ + + +   +  +R++  
Sbjct: 1702 EGTAQQRLAAEQELIRLR-------AETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754

Query: 350  AQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVM---- 405
            A+   AK+   E E    +K   E  EE +       +RL+       EL EE       
Sbjct: 1755 AE--LAKVR-AEMEVLLASKARAE--EESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809

Query: 406  ---AKKHQAFLVETCENNVKELESIL-DSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRT 461
               AK+ +    E       E E +L +     G+ T    + +          ERLRR 
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869

Query: 462  LTD---YQNKLEDASNEEKA-------------CNELDSTKQKIDSHTKNIKELQDKLAD 505
              D    + +LE+ + + KA              +EL+  K  ++   +  +++++++  
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929

Query: 506  VNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEE 565
            +           A+ E  +  ++   ++ L   E+ + +AA+ + +L    +   ++AEE
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQLAAEEERRRREAEE 1988

Query: 566  KLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLE 625
            +      + + L A     +Q +  L++           E + A + +  R  E+     
Sbjct: 1989 R------VQKSLAAEEEAARQRKAALEEV----------ERLKAKVEEARRLRERA---- 2028

Query: 626  YICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELE--LQYSELFL-EVQKRA 682
                 + ++ R+LQ  QE    ++  + KA      ++++EL+  LQ  +  L +++  A
Sbjct: 2029 -----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083

Query: 683  QKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLY 742
            +  +  AE+  E     E+   Q   +    ++ L Q+  EQ    A     A  L    
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKLRKEA 2142

Query: 743  SRSCALSTQRD---FLQEQVNTFELFKLE------IRTLAQA---LSTVEEKKQEEAKMK 790
             +  A   Q +     Q+Q    E+ K +      +R  AQ    L+T+  + +E    K
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2202

Query: 791  KKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKF 850
                + L R+  +   A  AA +   + +   S+   ME     +  L    E +++   
Sbjct: 2203 NLLDEELQRLKAE---ATEAARQRSQVEEELFSVRVQMEE----LSKLKARIEAENRALI 2255

Query: 851  PKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFA 910
             + +    R LQ       ++ +  +    A L     +A    ++    L      +  
Sbjct: 2256 LRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2310

Query: 911  KLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVN---TLALKYGLRGHVPITK 967
             L +K+  V E   L +   +   +K+ L Q  A  L +        L    +G     +
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKE-LAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2369

Query: 968  STASLQKQILGFTQR--LHAAEVERRSLRLE--VTEFKRSVNEMKKELDKAQGLQMQLNE 1023
            +    Q ++    +R  L  AE+ R   R E     F++   E+ ++L + +    +   
Sbjct: 2370 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2429

Query: 1024 FKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEE-ADKNQ 1082
              Q+  I  ++ +   E L  A+   E+ +  L ++A+ LQ  + +++    E+   + Q
Sbjct: 2430 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489

Query: 1083 TLGEAVKSLSEAKMELRR------------------KDQSLR-QLNRHLTQLEQDKRRLE 1123
             L ++  S  ++ ++  R                  K Q LR +  R   Q+EQ+++RL 
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549

Query: 1124 ENI-------HDAESALRMAAKDKECVANHMRAVENTL----HKVRDQISL 1163
             ++       H+AE  +R   ++ + +    R  E  L     ++R+Q+ L
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2600



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 256/1253 (20%), Positives = 487/1253 (38%), Gaps = 192/1253 (15%)

Query: 47   KEKLEITTKHNAELASYESQIAKL------RSEVEKGEALRQSLEYDLAVARKEAGLGRR 100
            +E +++ T H +EL +  SQ  K       R E E+  A +Q  E    +A  EA L + 
Sbjct: 1314 QEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK- 1371

Query: 101  AAEERLAEAHRIQEKLCAQNS--ELQAKTNET-----EKAFQTSQQKW--KEECRRFEHD 151
              + +LAEAH  Q K  A+    ELQ +  E      E A    QQK   +EE ++    
Sbjct: 1372 --QRQLAEAHA-QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1428

Query: 152  LEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEE 211
             E     IQ   R+ +   + + R+E+ ++  + + Q E  E +    E  L+  R + E
Sbjct: 1429 SEAE---IQAKARQAEAAERSRLRIEEEIR--VVRLQLEATERQRGGAEGELQALRARAE 1483

Query: 212  QWEAERRELQ-----FIVQEQDTAVQNMHKKVE---KLETEHMDCSDLLRRQTSELEFST 263
            + EA++R+ Q        Q QD + +    +VE   +++ E     +  R   +  E   
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543

Query: 264  QREERLRKEFEATTLRVRKLEENIE-----------------AERAAHLESKFNSE---I 303
            Q EE  R+  +A   R R+++  +E                 AE+ A LE     E   +
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603

Query: 304  IQLR--------------------IRDLEG-----------ALQVEKASQAEAVADLEII 332
             QLR                     R+LE             LQ E+ +Q +++A  E  
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663

Query: 333  KNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQK----KVIIDLSKR 388
            K   KE      R +  A+E   +   L ++   K ++L E   +Q+    + +I L   
Sbjct: 1664 KQ--KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1721

Query: 389  LQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTV--------SGQWTSG 440
             +  E+    L+EEL   ++  A   +  +    EL  +     V          +  S 
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781

Query: 441  IHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQ 500
              K K +  + +     L       +   E+A  + +   E D+ +Q+ ++     + L 
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQRAEAE----RVLA 1836

Query: 501  DKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFH 560
            +KLA +  E + L T   + E  +   + E + +    E E  Q  + E +      A H
Sbjct: 1837 EKLAAIG-EATRLKT---EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ-----AAQH 1887

Query: 561  K-DAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANE 619
            K D EE+L  L        A    +++ +G+++          ++E + AL A   +A  
Sbjct: 1888 KADIEERLAQLRK------ASDSELERQKGLVEDTLRQR--RQVEEEILALKASFEKAAA 1939

Query: 620  KIRHLEY----ICKNKSDTMRELQQTQ-----------------EDTFTKVAEQIKAQES 658
                LE     I  N  DT+R  +Q +                  +   +V + + A+E 
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999

Query: 659  CWHRQKKELELQYSELFLEV-----------QKRAQKFQEIAEKNMEKLNHIEKSHEQLV 707
               ++K  LE +   L  +V           Q+ A++ Q   E   ++L   EK+H   V
Sbjct: 2000 AARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2058

Query: 708  LENSHFKKLLSQTQREQMSLLAACALMAGALYPL--YSRSCALSTQRDFLQEQVNTFELF 765
             +    ++ L QT +++ S+L      A A       +    +  +R+  Q +    E  
Sbjct: 2059 QQK---EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2115

Query: 766  KL------EIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQ 819
            +L      + +  AQA +  E+ ++E  +   +  +      R+   A     + K   +
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2175

Query: 820  SCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTS-SDLLAAIIS 878
                    +E     + + +   + Q      + Q+ +    +A    +   + L ++  
Sbjct: 2176 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235

Query: 879  SMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSR-SITYVEKD 937
             M EL  +  + +  +R     LI   K++  + + + +  M+ +   ++R S+   E  
Sbjct: 2236 QMEELSKLKARIEAENR----ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2291

Query: 938  SLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEV 997
             L Q     L +   LA K  L+  +   +    L+ +     Q+   A+ + R L+ + 
Sbjct: 2292 RLRQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2350

Query: 998  TEFKRSVNEMKKELDKAQGLQMQLNEFKQSKL---ITHEKFESACEELNNALLREEQAQM 1054
             +  + + E      + QG Q  L   +Q +L      E+ +    E++ A  R E+   
Sbjct: 2351 EQMAQQLAE------ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404

Query: 1055 LLNEQAQQLQELNYKLELHSSEEADKNQTL-------GEAVKSLSEAKMELRRKDQSLRQ 1107
               +QA+++ E  ++ EL + E+    QTL           + L EA  EL R+ + L+Q
Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464

Query: 1108 LNRHLTQLEQDKRRL---EENIHDAESALRMAAKDKECVANHMRAVENTLHKV 1157
                L QL+ ++ +    E+ + + ++  +    +K+ +    R +E    K+
Sbjct: 2465 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 210/1134 (18%), Positives = 444/1134 (39%), Gaps = 161/1134 (14%)

Query: 59   ELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCA 118
            EL + ++ + KLR++ E  +    +L  +L  A++     ++   ER  E  R +E++  
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLL--------- 169
                 QA   +T+   Q   ++   + R +    +     +Q+  R  + +         
Sbjct: 1184 LLERWQAVLAQTDVR-QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242

Query: 170  -MKEKSRLEKTLQEALEKHQREKNEMESHIRE--TALEEFRLQEEQWEAERRELQFIVQE 226
             ++E+ R E+ L E +E+H  +  E +   ++   A++++ LQ   ++A+   +    ++
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1302

Query: 227  QDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEEN 286
                   +    E +  E++D    LR   SEL                TTL  + +   
Sbjct: 1303 P-----KVQSGSESVIQEYVD----LRTHYSEL----------------TTLTSQYI--- 1334

Query: 287  IEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYERE 346
                       KF SE ++ R+ + E   + ++A + E +A++E    + +++  A+ + 
Sbjct: 1335 -----------KFISETLR-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1382

Query: 347  KHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMA 406
            K  A+    +L    +E   + ++   D ++QK+ I +  ++L+ +        E  + A
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS-------EAEIQA 1435

Query: 407  KKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQ 466
            K  QA   E     ++E                             + + RL+   T+ Q
Sbjct: 1436 KARQAEAAERSRLRIEE----------------------------EIRVVRLQLEATERQ 1467

Query: 467  NKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALIST 526
                +   +       ++  QK  +  +  + L+ ++ D ++       + A R    + 
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526

Query: 527  LKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKL-TFLHTLYQHLVAGCVLIK 585
               E Q  L   E+ + QA ++E  L++      +  +  L T   +    L +      
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1586

Query: 586  QPEGMLDKFSWSELCAVLQENVDA-----LIADLNRANEKI-RHLEYICKNKSDTMRELQ 639
            +    L++    E  AV Q   +A       A+  RA E+  R LE      ++ +R   
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1646

Query: 640  QTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHI 699
            Q +E     VA+Q    ++   +QK+E E +      + +++A + +E+AE+ +EK   +
Sbjct: 1647 QAEE-----VAQQKSLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQL 1700

Query: 700  -EKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQ 758
             E + +Q +       +L ++T++ +        L+   L  L   + A + +R  L+ +
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQR----QLLEEELARLQREAAAATQKRQELEAE 1756

Query: 759  VNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILG 818
            +      + E+  L  + +  EE+ +  ++  K+  +               A R + L 
Sbjct: 1757 LAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEA-------------EAGRFRELA 1800

Query: 819  QSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCL-QALSWLTSSDLLAAII 877
            +  A L    E  K     L      + + +  +   E+L  + +A    T +++  A+ 
Sbjct: 1801 EEAARLRALAEEAKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI--ALK 1857

Query: 878  SSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKD 937
               AE + +   A+  +     L   AA++  A + ++++ + +       R    VE D
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVE-D 1915

Query: 938  SLVQRLAHGLHKVNTLALKYGLR----GHVPITKSTASLQKQILGFTQRLHAAEVERRSL 993
            +L QR      +   LALK        G   +      ++       +    AE+E    
Sbjct: 1916 TLRQRRQV---EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972

Query: 994  RLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQ 1053
            R    E +R   E ++ + K+   + +    +++ L   E+ ++  EE      R EQ  
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ-- 2030

Query: 1054 MLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLT 1113
                E A+QLQ         + E A K     E   + +     +++K+Q L+Q      
Sbjct: 2031 ----ESARQLQL--------AQEAAQKRLQAEEKAHAFA-----VQQKEQELQQT----- 2068

Query: 1114 QLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSA 1167
             L+Q++  L++   +AE+A R A + +E      R    +  +V +   L  SA
Sbjct: 2069 -LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 82/345 (23%), Positives = 157/345 (45%), Gaps = 35/345 (10%)

Query: 11   DTQRLKIASLDVKQILKNETELDITDN--LRKKLHWAKKEKLEITT--KHNAELASYESQ 66
            +  RL +A+ +  + L+   E D+     L +K+   K + ++  T  K  AEL   + +
Sbjct: 2279 EAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337

Query: 67   IAK--LRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQ 124
            +A+   R   E  E + Q L  +    ++     R+   E  AEA R++ ++ A+ S  Q
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV-AEMSRAQ 2396

Query: 125  AKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEAL 184
            A+  E  + F+   ++  E+  R E   +E+  ++Q      ++  ++     + L+EA+
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL----EIQRQQSDHDAERLREAI 2452

Query: 185  EKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQ----EQDTAVQNMH----- 235
             + +REK +++   +   L+   +Q  Q E   +E Q + Q    E+D+ +Q        
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2512

Query: 236  -KKVEKLETEHMDCSDLLR----RQTSELEFSTQR-----EERLRKEFEATTLRVRKLEE 285
              K+E+L  + +  +  LR    RQ  ++E   QR     EE  R++ EA     RK EE
Sbjct: 2513 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572

Query: 286  NIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLE 330
              + E+    + +  +E  Q R+R+    LQ+ +     A+A  E
Sbjct: 2573 LQQLEQQRRQQEELLAEENQ-RLRE---QLQLLEEQHRAALAHSE 2613



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 226/1124 (20%), Positives = 410/1124 (36%), Gaps = 178/1124 (15%)

Query: 143  EECRRFEHDLEE------RDNMIQNCNREYDLLMKEK-----SRLEKTLQEALEKHQREK 191
            EE R+  H LE       RD+         D LM E+     S   + L ++LE+  +E+
Sbjct: 920  EEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 979

Query: 192  NEMESHIRETALEEFRLQEEQWEAER-------------RELQFIVQEQDTA---VQNMH 235
            +  +  I E  L++ RLQ E  E                RE    + EQ  A   V+ + 
Sbjct: 980  SRCQRCISE--LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG 1037

Query: 236  KKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHL 295
            K V +L  E          +   L   +     LR E E T   + KLE+ + +  A +L
Sbjct: 1038 KGVARLSAE--------AEKVLALPEPSPAAPTLRSELELT---LGKLEQ-VRSLSAIYL 1085

Query: 296  ESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFA 355
            E     + I L IR  +GA +V +A + E + + + +     E+E+         + S  
Sbjct: 1086 EKL---KTISLVIRGTQGAEEVLRAHE-EQLKEAQAVPATLPELEAT--------KASLK 1133

Query: 356  KLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELV-MAKKHQAFLV 414
            KL    +        L +++   ++V   L +R    +      +E +  + ++ QA L 
Sbjct: 1134 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1193

Query: 415  ET------CENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNK 468
            +T       E   ++L    +S    G W     + +++  +           L D Q  
Sbjct: 1194 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP---------LADSQAV 1244

Query: 469  LEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLK 528
             E    E+    E++   +K++   +  K+  + + D   +L               T K
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV--------------TYK 1290

Query: 529  VELQNVLHCWEKEKAQAAQSE------------SELQKLSQAFHKDAEEKLTFLHT---- 572
             +L+ V    +K K Q+                SEL  L+  + K   E L  +      
Sbjct: 1291 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1350

Query: 573  LYQHLVAGCVLIKQPEGMLDK---FSWSELCAVLQENVDALIADLNRANEKIRHLEYIC- 628
              Q        + + E  L+K    + +   A  Q   +A         E +R  E    
Sbjct: 1351 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1410

Query: 629  --KNKSDTMRELQQTQEDTFTKVAEQIKAQESCWH-RQKKELELQYSELFLEVQKRAQKF 685
              + K     ELQQ ++ +  ++  + +  E+    R + E E++   L LE  +R +  
Sbjct: 1411 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470

Query: 686  QEIAEKNMEKLN-HIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSR 744
               AE  ++ L    E++  Q        ++L  Q Q E      A   +A       SR
Sbjct: 1471 ---AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA-------SR 1520

Query: 745  SCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKG 804
              A +      Q  +   E  +L+     + L   E ++  + ++  +T +       + 
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-------RS 1573

Query: 805  VIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGE--PQDKHKFPKHQKE------ 856
              A L + R     +  A L   ++     +  L    E   Q + +  + ++E      
Sbjct: 1574 AEAELQSKRASF-AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 857  --QLRCLQALSWLTSSDLLA---AIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAK 911
              QL+  +AL     ++ +A   ++  + AE Q    + +   R       G A+    +
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAVR 1685

Query: 912  LMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLA-LKYGLRGHVPITKSTA 970
              +     +E       R +    + +  QRLA     +   A  + G +    + +  A
Sbjct: 1686 QRELAEQELE-----KQRQLA---EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737

Query: 971  SLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLI 1030
             LQ++    TQ+    E E   +R E+     S    ++E         Q  E +  +  
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF- 1796

Query: 1031 THEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKS 1090
              E  E A      A   + Q Q+   + A+Q  E    L       A+K   +GEA + 
Sbjct: 1797 -RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL-------AEKLAAIGEATRL 1848

Query: 1091 LSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENI--HDAESALRMA----AKDKECVA 1144
             +EA++ L+ K+    +L R        +RRLEE    H A+   R+A    A D E + 
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE-LE 1907

Query: 1145 NHMRAVENTLHKVRD--------QISLSWSAASRNDFTLQLPKL 1180
                 VE+TL + R         + S   +AA + +  L+L ++
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  103 bits (258), Expect = 8e-22
 Identities = 171/784 (21%), Positives = 324/784 (41%), Gaps = 86/784 (10%)

Query: 64   ESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSEL 123
            E ++ +LR+E E+GE  RQ LE +LA  ++EA    +  +E  AE  +++ ++    +  
Sbjct: 1716 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1775

Query: 124  QAKTNETEKAFQTSQQKWKEECRRFEHDLEERDN---MIQNCNREYDL----LMKEKSRL 176
                 E+    + S+Q+ + E  RF    EE      + +   R+  L      ++++  
Sbjct: 1776 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1835

Query: 177  EKTLQE---ALEKHQREKNEMESHIRETALEEFRLQE--EQWEAERRELQFIVQEQDTAV 231
            E+ L E   A+ +  R K E E  ++E   E  RL+   E    +RR L+    +    +
Sbjct: 1836 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1895

Query: 232  QNMHKKVEK-----LETEHMDCSDLL--RRQTSE----LEFSTQREERLRKEFEATTLRV 280
            +    ++ K     LE +     D L  RRQ  E    L+ S ++    + E E    R+
Sbjct: 1896 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1955

Query: 281  R-KLEENIEAERAAHLESKFNSEII---QLRIRDLEGALQVEKASQAEAV----ADLEII 332
            R   E+ + ++  A LE+    ++    + R R+ E  +Q   A++ EA     A LE +
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015

Query: 333  KNEFKEVESAYEREKHNAQESFAKLNLLEK---------------EYFSKNKKLNEDIEE 377
            +    +VE A    +   QES  +L L ++                   K ++L + +++
Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2075

Query: 378  QKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQW 437
            ++ V+  L    +   ++  E +E  V A++  A         V+E E +  S     Q 
Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA----QSRRQVEEAERLKQSAEEQAQA 2131

Query: 438  TSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIK 497
             +                E+LR+     Q     A  E+ A  +  +   +++ H K  +
Sbjct: 2132 RA----------QAQAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2179

Query: 498  ELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQ 557
            +   + A V +EL+ L  +  + +   + L  ELQ +    + E  +AA+  S++++   
Sbjct: 2180 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL----KAEATEAARQRSQVEEELF 2235

Query: 558  AFHKDAEEKLTFLHTLYQHLVA-GCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNR 616
            +     EE    L  L   + A    LI + +    +F   E  A   + V    A L+ 
Sbjct: 2236 SVRVQMEE----LSKLKARIEAENRALILRDKDNTQRFLQEE--AEKMKQVAEEAARLSV 2289

Query: 617  ANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKA-QESCWHRQKKELELQYSELF 675
            A ++   L  + +      R L +        + E+++A QE+   + + EL  Q  EL 
Sbjct: 2290 AAQEAARLRQLAEEDLAQQRALAEKM------LKEKMQAVQEATRLKAEAELLQQQKEL- 2342

Query: 676  LEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMA 735
               Q++A++ QE  E+  ++L   E    Q  LE    ++L    + E++ L    A M+
Sbjct: 2343 --AQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKL--RVAEMS 2397

Query: 736  GALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFK 795
             A       +     Q + + E+++  EL   E  TL Q L    ++   +A+  ++   
Sbjct: 2398 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2457

Query: 796  GLIR 799
             L R
Sbjct: 2458 ELER 2461



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 175/838 (20%), Positives = 345/838 (41%), Gaps = 117/838 (13%)

Query: 55   KHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARK-----EAGLGRRAAEERLAEA 109
            K  A  A  E ++ ++RS  E  + LR   + +L  AR+     E    RR AEER+ ++
Sbjct: 1940 KAAAGKAELELELGRIRSNAE--DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1997

Query: 110  HRIQEKLCAQNS-------ELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNC 162
               +E+   Q          L+AK  E  +  + ++Q   E  R+ +   E     +Q  
Sbjct: 1998 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ---ESARQLQLAQEAAQKRLQAE 2054

Query: 163  NREYDLLMKEKSR-LEKTLQEALEKHQREKNEMESHIRETA-LEEFRLQEEQWEAERRE- 219
             + +   +++K + L++TLQ+      + + E E+  R     EE R+Q E+  A+ R  
Sbjct: 2055 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2114

Query: 220  ------LQFIVQEQDTAVQNMHKKVEKLETE---------HMDCSDLLRRQTSELEFSTQ 264
                  L+   +EQ  A        EKL  E           + + L ++Q ++ E    
Sbjct: 2115 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2174

Query: 265  R---EERLRK----EFEATTLRVRK---------LEENI-----EAERAAHLESKFNSEI 303
            +   E+ LR+    E E TTLR++          L+E +     EA  AA   S+   E+
Sbjct: 2175 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2234

Query: 304  IQLRIRDLEGA---LQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLL 360
              +R++  E +    ++E  ++A  + D +   N  + ++   E+ K  A+E+ A+L++ 
Sbjct: 2235 FSVRVQMEELSKLKARIEAENRALILRDKD---NTQRFLQEEAEKMKQVAEEA-ARLSVA 2290

Query: 361  EKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENN 420
             +E     +   ED+ +Q+ +   + K      +  + L+ E  + ++ +    E     
Sbjct: 2291 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2350

Query: 421  VKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACN 480
             ++ E +        Q              F   LE  R      Q +LE ++  E+   
Sbjct: 2351 QEDKEQMAQQLAEETQ-------------GFQRTLEAER------QRQLEMSAEAERLKL 2391

Query: 481  ELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEK 540
             +    +      ++ +  + +  ++ ++L        ++  L+ TL+++ Q   H  E+
Sbjct: 2392 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2451

Query: 541  EKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELC 600
             +   A+ E E +KL Q      E KL  L +     V    L+++ + +   F  SE  
Sbjct: 2452 LREAIAELEREKEKLQQ------EAKLLQLKSEEMQTVQQEQLLQETQALQQSFL-SEKD 2504

Query: 601  AVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCW 660
            ++LQ         + +   K+  L      K+  +RE QQ Q+    +  +++ A     
Sbjct: 2505 SLLQRE-----RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2559

Query: 661  HRQKKELE----LQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKL 716
             R++ E E     +  EL    Q+R Q+ + +AE+N       ++  EQL L     +  
Sbjct: 2560 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN-------QRLREQLQLLEEQHRAA 2612

Query: 717  LSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDF--LQEQVNTFELFKL------E 768
            L+ ++    S +AA   +      L   +     +  F  L+ +V+   L +       E
Sbjct: 2613 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2672

Query: 769  IRTLAQALSTVEE-KKQEEAK---MKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCA 822
            ++ LAQ  +TV+E  ++E+ +     + +  GL+       ++V AA + ++L    A
Sbjct: 2673 LQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTA 2730



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 235/1168 (20%), Positives = 491/1168 (42%), Gaps = 144/1168 (12%)

Query: 11   DTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKL 70
            + +RL+    D  Q  K + E+++   ++ +   A++++  +       L + E++    
Sbjct: 1499 EAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1557

Query: 71   RSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNET 130
            ++EVE+   ++ +LE     A  E    R +  E+ A+  R  ++     ++L+      
Sbjct: 1558 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR------ 1611

Query: 131  EKAFQTSQQKWKEECRRFEHDLE-ERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQR 189
            E+A + +QQ+ + E  R E + E ER  +  N      L  +E ++ +K+L +A  + Q+
Sbjct: 1612 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQK 1670

Query: 190  EKNEMESHIR----ETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEH 245
            E+ E E+  R    E A+ +  L E++ E +R+  +   Q++  A Q + +   + ETE 
Sbjct: 1671 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL--RAETEQ 1728

Query: 246  MDCS-DLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERA-AHLESKFNSEI 303
             +    LL  + + L+       + R+E EA   +VR   E + A +A A  ES+  SE 
Sbjct: 1729 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1788

Query: 304  IQLRIRDLEGALQ--VEKASQAEAVADLEIIKNEFKEVESAYER--------EKHNA--- 350
             + R+    G  +   E+A++  A+A+    + +  E ++A +R        EK  A   
Sbjct: 1789 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1848

Query: 351  ---QESFAKLNLLEKEYFSKN-KKLNEDIEEQKKVIIDLSKRLQYN-EKSCSELQEELVM 405
                ++ A++ L EKE  ++  ++L ED   Q++ + + + + + + E+  ++L++    
Sbjct: 1849 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1908

Query: 406  AKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDY 465
              + Q  LVE      +++E  + +   S        K         + L R+R    D 
Sbjct: 1909 ELERQKGLVEDTLRQRRQVEEEILALKAS------FEKAAAGKAELELELGRIRSNAEDT 1962

Query: 466  QNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREAL-- 523
                E A  E     +L + +++        +E +++   V K L+        R+A   
Sbjct: 1963 LRSKEQAELEAARQRQLAAEEER------RRREAEER---VQKSLAAEEEAARQRKAALE 2013

Query: 524  -ISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHK--DAEEKLTFLHTLYQHLVAG 580
             +  LK +++      E+ + ++A+   +LQ   +A  K   AEEK      + Q     
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESAR---QLQLAQEAAQKRLQAEEK-AHAFAVQQKEQEL 2069

Query: 581  CVLIKQPEGMLDKFSWSELCA--VLQENVDALIADLNRANEKIRHLEYICKNKSDTMREL 638
               ++Q + +LD+       A    +E  +A +     A +  R +E   + K     + 
Sbjct: 2070 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129

Query: 639  Q-----QTQEDTFTKVAEQIKA------QESCWHRQKKELELQYSELFLE--VQKRAQKF 685
            Q     Q   +   K AEQ  A      Q +   +Q  + E++  + F E  ++++AQ  
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2189

Query: 686  QEIA------EKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALY 739
            QE+       E+   + N +++  ++L  E +   +  SQ + E  S+      ++    
Sbjct: 2190 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2249

Query: 740  PLYSRSCAL------STQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKT 793
             + + + AL      +TQR FLQE+         +++ +A+  + +    QE A++++  
Sbjct: 2250 RIEAENRALILRDKDNTQR-FLQEEAE-------KMKQVAEEAARLSVAAQEAARLRQLA 2301

Query: 794  FKGLI-------RIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQD 846
             + L        ++ ++ + AV  A RLK    + A L    +   +     +   + Q 
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLK----AEAELLQQQKELAQEQARRLQEDKEQM 2357

Query: 847  KHKFPKHQKEQLRCLQA-----LSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLL 901
              +  +  +   R L+A     L     ++ L   ++ M+  Q    +A+ +++      
Sbjct: 2358 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQ------ 2408

Query: 902  IGAAKNSFAKLMDKISLVMECIPLHSSRSITYVE--------KDSLVQRLAHGLHKVNTL 953
                   F K  ++I   +    L +   +T V+         D   +RL   + ++   
Sbjct: 2409 ------RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2462

Query: 954  ALKYGLRGHVPITKSTASL---QKQILGFTQRLHAAEVERRSLRLEVTEF----KRSVNE 1006
              K      +   KS       Q+Q+L  TQ L  + +  +   L+   F    K  + +
Sbjct: 2463 KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2522

Query: 1007 M-KKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQE 1065
            + + E+ KAQ L+ +    +Q      ++  ++ EE   A  R+ +A+  +  + ++LQ+
Sbjct: 2523 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEELQQ 2579

Query: 1066 LNYKLELHSSEEADKNQTLGEAVKSLSE 1093
            L  +        A++NQ L E ++ L E
Sbjct: 2580 LEQQRRQQEELLAEENQRLREQLQLLEE 2607



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 246/1251 (19%), Positives = 495/1251 (39%), Gaps = 165/1251 (13%)

Query: 3    LNTSSNTGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELAS 62
            L  SS      + + A    +  L+ E E+ +   +R +L   ++++     +  A  A 
Sbjct: 1429 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRV---VRLQLEATERQRGGAEGELQALRAR 1485

Query: 63   YESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSE 122
             E   A+ R   E+ E LR+ ++ D +  +++A +   +  +  AEA R +++      E
Sbjct: 1486 AEEAEAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1544

Query: 123  LQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKS-RLEKTLQ 181
            L+ +  E E+  + ++    E  R+ +  LE      +   +       EK+ +LE++LQ
Sbjct: 1545 LRLQAEEAERRLRQAEV---ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1601

Query: 182  E-----ALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRE-LQFIVQEQDTAVQNMH 235
            E     A  + + E+   +    E A EE   + E+W+ +  E L+  +Q ++ A Q   
Sbjct: 1602 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ--- 1658

Query: 236  KKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKL-EENIE-----A 289
            K + + E E         +Q  E E    RE R R + E   +R R+L E+ +E     A
Sbjct: 1659 KSLAQAEAE---------KQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQLA 1705

Query: 290  ERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHN 349
            E  A        E+I+LR        + E+  Q   + + E+ + + +   +  +R++  
Sbjct: 1706 EGTAQQRLAAEQELIRLR-------AETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1758

Query: 350  AQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVM---- 405
            A+   AK+   E E    +K   E  EE +       +RL+       EL EE       
Sbjct: 1759 AE--LAKVR-AEMEVLLASKARAE--EESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1813

Query: 406  ---AKKHQAFLVETCENNVKELESIL-DSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRT 461
               AK+ +    E       E E +L +     G+ T    + +          ERLRR 
Sbjct: 1814 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1873

Query: 462  LTD---YQNKLEDASNEEKA-------------CNELDSTKQKIDSHTKNIKELQDKLAD 505
              D    + +LE+ + + KA              +EL+  K  ++   +  +++++++  
Sbjct: 1874 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1933

Query: 506  VNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEE 565
            +           A+ E  +  ++   ++ L   E+ + +AA+ + +L    +   ++AEE
Sbjct: 1934 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQLAAEEERRRREAEE 1992

Query: 566  KLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLE 625
            +      + + L A     +Q +  L++           E + A + +  R  E+     
Sbjct: 1993 R------VQKSLAAEEEAARQRKAALEEV----------ERLKAKVEEARRLRERA---- 2032

Query: 626  YICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELE--LQYSELFL-EVQKRA 682
                 + ++ R+LQ  QE    ++  + KA      ++++EL+  LQ  +  L +++  A
Sbjct: 2033 -----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087

Query: 683  QKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLY 742
            +  +  AE+  E     E+   Q   +    ++ L Q+  EQ    A     A  L    
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKLRKEA 2146

Query: 743  SRSCALSTQRD---FLQEQVNTFELFKLE------IRTLAQA---LSTVEEKKQEEAKMK 790
             +  A   Q +     Q+Q    E+ K +      +R  AQ    L+T+  + +E    K
Sbjct: 2147 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2206

Query: 791  KKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKF 850
                + L R+  +   A  AA +   + +   S+   ME     +  L    E +++   
Sbjct: 2207 NLLDEELQRLKAE---ATEAARQRSQVEEELFSVRVQMEE----LSKLKARIEAENRALI 2259

Query: 851  PKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFA 910
             + +    R LQ       ++ +  +    A L     +A    ++    L      +  
Sbjct: 2260 LRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2314

Query: 911  KLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVN---TLALKYGLRGHVPITK 967
             L +K+  V E   L +   +   +K+ L Q  A  L +        L    +G     +
Sbjct: 2315 MLKEKMQAVQEATRLKAEAELLQQQKE-LAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2373

Query: 968  STASLQKQILGFTQR--LHAAEVERRSLRLE--VTEFKRSVNEMKKELDKAQGLQMQLNE 1023
            +    Q ++    +R  L  AE+ R   R E     F++   E+ ++L + +    +   
Sbjct: 2374 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2433

Query: 1024 FKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEE-ADKNQ 1082
              Q+  I  ++ +   E L  A+   E+ +  L ++A+ LQ  + +++    E+   + Q
Sbjct: 2434 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2493

Query: 1083 TLGEAVKSLSEAKMELRR------------------KDQSLR-QLNRHLTQLEQDKRRLE 1123
             L ++  S  ++ ++  R                  K Q LR +  R   Q+EQ+++RL 
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553

Query: 1124 ENI-------HDAESALRMAAKDKECVANHMRAVENTL----HKVRDQISL 1163
             ++       H+AE  +R   ++ + +    R  E  L     ++R+Q+ L
Sbjct: 2554 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2604



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 256/1253 (20%), Positives = 487/1253 (38%), Gaps = 192/1253 (15%)

Query: 47   KEKLEITTKHNAELASYESQIAKL------RSEVEKGEALRQSLEYDLAVARKEAGLGRR 100
            +E +++ T H +EL +  SQ  K       R E E+  A +Q  E    +A  EA L + 
Sbjct: 1318 QEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK- 1375

Query: 101  AAEERLAEAHRIQEKLCAQNS--ELQAKTNET-----EKAFQTSQQKW--KEECRRFEHD 151
              + +LAEAH  Q K  A+    ELQ +  E      E A    QQK   +EE ++    
Sbjct: 1376 --QRQLAEAHA-QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1432

Query: 152  LEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEE 211
             E     IQ   R+ +   + + R+E+ ++  + + Q E  E +    E  L+  R + E
Sbjct: 1433 SEAE---IQAKARQAEAAERSRLRIEEEIR--VVRLQLEATERQRGGAEGELQALRARAE 1487

Query: 212  QWEAERRELQ-----FIVQEQDTAVQNMHKKVE---KLETEHMDCSDLLRRQTSELEFST 263
            + EA++R+ Q        Q QD + +    +VE   +++ E     +  R   +  E   
Sbjct: 1488 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1547

Query: 264  QREERLRKEFEATTLRVRKLEENIE-----------------AERAAHLESKFNSE---I 303
            Q EE  R+  +A   R R+++  +E                 AE+ A LE     E   +
Sbjct: 1548 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1607

Query: 304  IQLR--------------------IRDLEG-----------ALQVEKASQAEAVADLEII 332
             QLR                     R+LE             LQ E+ +Q +++A  E  
Sbjct: 1608 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1667

Query: 333  KNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQK----KVIIDLSKR 388
            K   KE      R +  A+E   +   L ++   K ++L E   +Q+    + +I L   
Sbjct: 1668 KQ--KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1725

Query: 389  LQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTV--------SGQWTSG 440
             +  E+    L+EEL   ++  A   +  +    EL  +     V          +  S 
Sbjct: 1726 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1785

Query: 441  IHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQ 500
              K K +  + +     L       +   E+A  + +   E D+ +Q+ ++     + L 
Sbjct: 1786 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQRAEAE----RVLA 1840

Query: 501  DKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFH 560
            +KLA +  E + L T   + E  +   + E + +    E E  Q  + E +      A H
Sbjct: 1841 EKLAAIG-EATRLKT---EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ-----AAQH 1891

Query: 561  K-DAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANE 619
            K D EE+L  L        A    +++ +G+++          ++E + AL A   +A  
Sbjct: 1892 KADIEERLAQLRK------ASDSELERQKGLVEDTLRQR--RQVEEEILALKASFEKAAA 1943

Query: 620  KIRHLEY----ICKNKSDTMRELQQTQ-----------------EDTFTKVAEQIKAQES 658
                LE     I  N  DT+R  +Q +                  +   +V + + A+E 
Sbjct: 1944 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003

Query: 659  CWHRQKKELELQYSELFLEV-----------QKRAQKFQEIAEKNMEKLNHIEKSHEQLV 707
               ++K  LE +   L  +V           Q+ A++ Q   E   ++L   EK+H   V
Sbjct: 2004 AARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2062

Query: 708  LENSHFKKLLSQTQREQMSLLAACALMAGALYPL--YSRSCALSTQRDFLQEQVNTFELF 765
             +    ++ L QT +++ S+L      A A       +    +  +R+  Q +    E  
Sbjct: 2063 QQK---EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2119

Query: 766  KL------EIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQ 819
            +L      + +  AQA +  E+ ++E  +   +  +      R+   A     + K   +
Sbjct: 2120 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2179

Query: 820  SCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTS-SDLLAAIIS 878
                    +E     + + +   + Q      + Q+ +    +A    +   + L ++  
Sbjct: 2180 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2239

Query: 879  SMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSR-SITYVEKD 937
             M EL  +  + +  +R     LI   K++  + + + +  M+ +   ++R S+   E  
Sbjct: 2240 QMEELSKLKARIEAENR----ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2295

Query: 938  SLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEV 997
             L Q     L +   LA K  L+  +   +    L+ +     Q+   A+ + R L+ + 
Sbjct: 2296 RLRQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2354

Query: 998  TEFKRSVNEMKKELDKAQGLQMQLNEFKQSKL---ITHEKFESACEELNNALLREEQAQM 1054
             +  + + E      + QG Q  L   +Q +L      E+ +    E++ A  R E+   
Sbjct: 2355 EQMAQQLAE------ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2408

Query: 1055 LLNEQAQQLQELNYKLELHSSEEADKNQTL-------GEAVKSLSEAKMELRRKDQSLRQ 1107
               +QA+++ E  ++ EL + E+    QTL           + L EA  EL R+ + L+Q
Sbjct: 2409 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2468

Query: 1108 LNRHLTQLEQDKRRL---EENIHDAESALRMAAKDKECVANHMRAVENTLHKV 1157
                L QL+ ++ +    E+ + + ++  +    +K+ +    R +E    K+
Sbjct: 2469 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2520



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 210/1134 (18%), Positives = 444/1134 (39%), Gaps = 161/1134 (14%)

Query: 59   ELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCA 118
            EL + ++ + KLR++ E  +    +L  +L  A++     ++   ER  E  R +E++  
Sbjct: 1128 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1187

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLL--------- 169
                 QA   +T+   Q   ++   + R +    +     +Q+  R  + +         
Sbjct: 1188 LLERWQAVLAQTDVR-QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1246

Query: 170  -MKEKSRLEKTLQEALEKHQREKNEMESHIRE--TALEEFRLQEEQWEAERRELQFIVQE 226
             ++E+ R E+ L E +E+H  +  E +   ++   A++++ LQ   ++A+   +    ++
Sbjct: 1247 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1306

Query: 227  QDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEEN 286
                   +    E +  E++D    LR   SEL                TTL  + +   
Sbjct: 1307 P-----KVQSGSESVIQEYVD----LRTHYSEL----------------TTLTSQYI--- 1338

Query: 287  IEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYERE 346
                       KF SE ++ R+ + E   + ++A + E +A++E    + +++  A+ + 
Sbjct: 1339 -----------KFISETLR-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1386

Query: 347  KHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMA 406
            K  A+    +L    +E   + ++   D ++QK+ I +  ++L+ +        E  + A
Sbjct: 1387 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS-------EAEIQA 1439

Query: 407  KKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQ 466
            K  QA   E     ++E                             + + RL+   T+ Q
Sbjct: 1440 KARQAEAAERSRLRIEE----------------------------EIRVVRLQLEATERQ 1471

Query: 467  NKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALIST 526
                +   +       ++  QK  +  +  + L+ ++ D ++       + A R    + 
Sbjct: 1472 RGGAEGELQALRARAEEAEAQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1530

Query: 527  LKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKL-TFLHTLYQHLVAGCVLIK 585
               E Q  L   E+ + QA ++E  L++      +  +  L T   +    L +      
Sbjct: 1531 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1590

Query: 586  QPEGMLDKFSWSELCAVLQENVDA-----LIADLNRANEKI-RHLEYICKNKSDTMRELQ 639
            +    L++    E  AV Q   +A       A+  RA E+  R LE      ++ +R   
Sbjct: 1591 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1650

Query: 640  QTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHI 699
            Q +E     VA+Q    ++   +QK+E E +      + +++A + +E+AE+ +EK   +
Sbjct: 1651 QAEE-----VAQQKSLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQL 1704

Query: 700  -EKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQ 758
             E + +Q +       +L ++T++ +        L+   L  L   + A + +R  L+ +
Sbjct: 1705 AEGTAQQRLAAEQELIRLRAETEQGEQQR----QLLEEELARLQREAAAATQKRQELEAE 1760

Query: 759  VNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILG 818
            +      + E+  L  + +  EE+ +  ++  K+  +               A R + L 
Sbjct: 1761 LAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEA-------------EAGRFRELA 1804

Query: 819  QSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCL-QALSWLTSSDLLAAII 877
            +  A L    E  K     L      + + +  +   E+L  + +A    T +++  A+ 
Sbjct: 1805 EEAARLRALAEEAKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI--ALK 1861

Query: 878  SSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKD 937
               AE + +   A+  +     L   AA++  A + ++++ + +       R    VE D
Sbjct: 1862 EKEAENERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVE-D 1919

Query: 938  SLVQRLAHGLHKVNTLALKYGLR----GHVPITKSTASLQKQILGFTQRLHAAEVERRSL 993
            +L QR      +   LALK        G   +      ++       +    AE+E    
Sbjct: 1920 TLRQRRQV---EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976

Query: 994  RLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQ 1053
            R    E +R   E ++ + K+   + +    +++ L   E+ ++  EE      R EQ  
Sbjct: 1977 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ-- 2034

Query: 1054 MLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLT 1113
                E A+QLQ         + E A K     E   + +     +++K+Q L+Q      
Sbjct: 2035 ----ESARQLQL--------AQEAAQKRLQAEEKAHAFA-----VQQKEQELQQT----- 2072

Query: 1114 QLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSA 1167
             L+Q++  L++   +AE+A R A + +E      R    +  +V +   L  SA
Sbjct: 2073 -LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2125



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 82/345 (23%), Positives = 157/345 (45%), Gaps = 35/345 (10%)

Query: 11   DTQRLKIASLDVKQILKNETELDITDN--LRKKLHWAKKEKLEITT--KHNAELASYESQ 66
            +  RL +A+ +  + L+   E D+     L +K+   K + ++  T  K  AEL   + +
Sbjct: 2283 EAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2341

Query: 67   IAK--LRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQ 124
            +A+   R   E  E + Q L  +    ++     R+   E  AEA R++ ++ A+ S  Q
Sbjct: 2342 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV-AEMSRAQ 2400

Query: 125  AKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEAL 184
            A+  E  + F+   ++  E+  R E   +E+  ++Q      ++  ++     + L+EA+
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL----EIQRQQSDHDAERLREAI 2456

Query: 185  EKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQ----EQDTAVQNMH----- 235
             + +REK +++   +   L+   +Q  Q E   +E Q + Q    E+D+ +Q        
Sbjct: 2457 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2516

Query: 236  -KKVEKLETEHMDCSDLLR----RQTSELEFSTQR-----EERLRKEFEATTLRVRKLEE 285
              K+E+L  + +  +  LR    RQ  ++E   QR     EE  R++ EA     RK EE
Sbjct: 2517 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2576

Query: 286  NIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLE 330
              + E+    + +  +E  Q R+R+    LQ+ +     A+A  E
Sbjct: 2577 LQQLEQQRRQQEELLAEENQ-RLRE---QLQLLEEQHRAALAHSE 2617



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 226/1124 (20%), Positives = 410/1124 (36%), Gaps = 178/1124 (15%)

Query: 143  EECRRFEHDLEE------RDNMIQNCNREYDLLMKEK-----SRLEKTLQEALEKHQREK 191
            EE R+  H LE       RD+         D LM E+     S   + L ++LE+  +E+
Sbjct: 924  EEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 983

Query: 192  NEMESHIRETALEEFRLQEEQWEAER-------------RELQFIVQEQDTA---VQNMH 235
            +  +  I E  L++ RLQ E  E                RE    + EQ  A   V+ + 
Sbjct: 984  SRCQRCISE--LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG 1041

Query: 236  KKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHL 295
            K V +L  E          +   L   +     LR E E T   + KLE+ + +  A +L
Sbjct: 1042 KGVARLSAE--------AEKVLALPEPSPAAPTLRSELELT---LGKLEQ-VRSLSAIYL 1089

Query: 296  ESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFA 355
            E     + I L IR  +GA +V +A + E + + + +     E+E+         + S  
Sbjct: 1090 EKL---KTISLVIRGTQGAEEVLRAHE-EQLKEAQAVPATLPELEAT--------KASLK 1137

Query: 356  KLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELV-MAKKHQAFLV 414
            KL    +        L +++   ++V   L +R    +      +E +  + ++ QA L 
Sbjct: 1138 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1197

Query: 415  ET------CENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNK 468
            +T       E   ++L    +S    G W     + +++  +           L D Q  
Sbjct: 1198 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP---------LADSQAV 1248

Query: 469  LEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLK 528
             E    E+    E++   +K++   +  K+  + + D   +L               T K
Sbjct: 1249 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV--------------TYK 1294

Query: 529  VELQNVLHCWEKEKAQAAQSE------------SELQKLSQAFHKDAEEKLTFLHT---- 572
             +L+ V    +K K Q+                SEL  L+  + K   E L  +      
Sbjct: 1295 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1354

Query: 573  LYQHLVAGCVLIKQPEGMLDK---FSWSELCAVLQENVDALIADLNRANEKIRHLEYIC- 628
              Q        + + E  L+K    + +   A  Q   +A         E +R  E    
Sbjct: 1355 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1414

Query: 629  --KNKSDTMRELQQTQEDTFTKVAEQIKAQESCWH-RQKKELELQYSELFLEVQKRAQKF 685
              + K     ELQQ ++ +  ++  + +  E+    R + E E++   L LE  +R +  
Sbjct: 1415 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1474

Query: 686  QEIAEKNMEKLN-HIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSR 744
               AE  ++ L    E++  Q        ++L  Q Q E      A   +A       SR
Sbjct: 1475 ---AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA-------SR 1524

Query: 745  SCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKG 804
              A +      Q  +   E  +L+     + L   E ++  + ++  +T +       + 
Sbjct: 1525 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-------RS 1577

Query: 805  VIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGE--PQDKHKFPKHQKE------ 856
              A L + R     +  A L   ++     +  L    E   Q + +  + ++E      
Sbjct: 1578 AEAELQSKRASF-AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636

Query: 857  --QLRCLQALSWLTSSDLLA---AIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAK 911
              QL+  +AL     ++ +A   ++  + AE Q    + +   R       G A+    +
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAVR 1689

Query: 912  LMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLA-LKYGLRGHVPITKSTA 970
              +     +E       R +    + +  QRLA     +   A  + G +    + +  A
Sbjct: 1690 QRELAEQELE-----KQRQLA---EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1741

Query: 971  SLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLI 1030
             LQ++    TQ+    E E   +R E+     S    ++E         Q  E +  +  
Sbjct: 1742 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF- 1800

Query: 1031 THEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKS 1090
              E  E A      A   + Q Q+   + A+Q  E    L       A+K   +GEA + 
Sbjct: 1801 -RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL-------AEKLAAIGEATRL 1852

Query: 1091 LSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENI--HDAESALRMA----AKDKECVA 1144
             +EA++ L+ K+    +L R        +RRLEE    H A+   R+A    A D E + 
Sbjct: 1853 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE-LE 1911

Query: 1145 NHMRAVENTLHKVRD--------QISLSWSAASRNDFTLQLPKL 1180
                 VE+TL + R         + S   +AA + +  L+L ++
Sbjct: 1912 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1955


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  103 bits (258), Expect = 8e-22
 Identities = 171/784 (21%), Positives = 324/784 (41%), Gaps = 86/784 (10%)

Query: 64   ESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSEL 123
            E ++ +LR+E E+GE  RQ LE +LA  ++EA    +  +E  AE  +++ ++    +  
Sbjct: 1712 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771

Query: 124  QAKTNETEKAFQTSQQKWKEECRRFEHDLEERDN---MIQNCNREYDL----LMKEKSRL 176
                 E+    + S+Q+ + E  RF    EE      + +   R+  L      ++++  
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831

Query: 177  EKTLQE---ALEKHQREKNEMESHIRETALEEFRLQE--EQWEAERRELQFIVQEQDTAV 231
            E+ L E   A+ +  R K E E  ++E   E  RL+   E    +RR L+    +    +
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891

Query: 232  QNMHKKVEK-----LETEHMDCSDLL--RRQTSE----LEFSTQREERLRKEFEATTLRV 280
            +    ++ K     LE +     D L  RRQ  E    L+ S ++    + E E    R+
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951

Query: 281  R-KLEENIEAERAAHLESKFNSEII---QLRIRDLEGALQVEKASQAEAV----ADLEII 332
            R   E+ + ++  A LE+    ++    + R R+ E  +Q   A++ EA     A LE +
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011

Query: 333  KNEFKEVESAYEREKHNAQESFAKLNLLEK---------------EYFSKNKKLNEDIEE 377
            +    +VE A    +   QES  +L L ++                   K ++L + +++
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071

Query: 378  QKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQW 437
            ++ V+  L    +   ++  E +E  V A++  A         V+E E +  S     Q 
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA----QSRRQVEEAERLKQSAEEQAQA 2127

Query: 438  TSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIK 497
             +                E+LR+     Q     A  E+ A  +  +   +++ H K  +
Sbjct: 2128 RA----------QAQAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2175

Query: 498  ELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQ 557
            +   + A V +EL+ L  +  + +   + L  ELQ +    + E  +AA+  S++++   
Sbjct: 2176 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL----KAEATEAARQRSQVEEELF 2231

Query: 558  AFHKDAEEKLTFLHTLYQHLVA-GCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNR 616
            +     EE    L  L   + A    LI + +    +F   E  A   + V    A L+ 
Sbjct: 2232 SVRVQMEE----LSKLKARIEAENRALILRDKDNTQRFLQEE--AEKMKQVAEEAARLSV 2285

Query: 617  ANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKA-QESCWHRQKKELELQYSELF 675
            A ++   L  + +      R L +        + E+++A QE+   + + EL  Q  EL 
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKM------LKEKMQAVQEATRLKAEAELLQQQKEL- 2338

Query: 676  LEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMA 735
               Q++A++ QE  E+  ++L   E    Q  LE    ++L    + E++ L    A M+
Sbjct: 2339 --AQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKL--RVAEMS 2393

Query: 736  GALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFK 795
             A       +     Q + + E+++  EL   E  TL Q L    ++   +A+  ++   
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453

Query: 796  GLIR 799
             L R
Sbjct: 2454 ELER 2457



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 175/838 (20%), Positives = 345/838 (41%), Gaps = 117/838 (13%)

Query: 55   KHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARK-----EAGLGRRAAEERLAEA 109
            K  A  A  E ++ ++RS  E  + LR   + +L  AR+     E    RR AEER+ ++
Sbjct: 1936 KAAAGKAELELELGRIRSNAE--DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993

Query: 110  HRIQEKLCAQNS-------ELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNC 162
               +E+   Q          L+AK  E  +  + ++Q   E  R+ +   E     +Q  
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ---ESARQLQLAQEAAQKRLQAE 2050

Query: 163  NREYDLLMKEKSR-LEKTLQEALEKHQREKNEMESHIRETA-LEEFRLQEEQWEAERRE- 219
             + +   +++K + L++TLQ+      + + E E+  R     EE R+Q E+  A+ R  
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110

Query: 220  ------LQFIVQEQDTAVQNMHKKVEKLETE---------HMDCSDLLRRQTSELEFSTQ 264
                  L+   +EQ  A        EKL  E           + + L ++Q ++ E    
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2170

Query: 265  R---EERLRK----EFEATTLRVRK---------LEENI-----EAERAAHLESKFNSEI 303
            +   E+ LR+    E E TTLR++          L+E +     EA  AA   S+   E+
Sbjct: 2171 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2230

Query: 304  IQLRIRDLEGA---LQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLL 360
              +R++  E +    ++E  ++A  + D +   N  + ++   E+ K  A+E+ A+L++ 
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRALILRDKD---NTQRFLQEEAEKMKQVAEEA-ARLSVA 2286

Query: 361  EKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENN 420
             +E     +   ED+ +Q+ +   + K      +  + L+ E  + ++ +    E     
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2346

Query: 421  VKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACN 480
             ++ E +        Q              F   LE  R      Q +LE ++  E+   
Sbjct: 2347 QEDKEQMAQQLAEETQ-------------GFQRTLEAER------QRQLEMSAEAERLKL 2387

Query: 481  ELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEK 540
             +    +      ++ +  + +  ++ ++L        ++  L+ TL+++ Q   H  E+
Sbjct: 2388 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2447

Query: 541  EKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELC 600
             +   A+ E E +KL Q      E KL  L +     V    L+++ + +   F  SE  
Sbjct: 2448 LREAIAELEREKEKLQQ------EAKLLQLKSEEMQTVQQEQLLQETQALQQSFL-SEKD 2500

Query: 601  AVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCW 660
            ++LQ         + +   K+  L      K+  +RE QQ Q+    +  +++ A     
Sbjct: 2501 SLLQRE-----RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555

Query: 661  HRQKKELE----LQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKL 716
             R++ E E     +  EL    Q+R Q+ + +AE+N       ++  EQL L     +  
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN-------QRLREQLQLLEEQHRAA 2608

Query: 717  LSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDF--LQEQVNTFELFKL------E 768
            L+ ++    S +AA   +      L   +     +  F  L+ +V+   L +       E
Sbjct: 2609 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2668

Query: 769  IRTLAQALSTVEE-KKQEEAK---MKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCA 822
            ++ LAQ  +TV+E  ++E+ +     + +  GL+       ++V AA + ++L    A
Sbjct: 2669 LQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTA 2726



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 235/1168 (20%), Positives = 491/1168 (42%), Gaps = 144/1168 (12%)

Query: 11   DTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKL 70
            + +RL+    D  Q  K + E+++   ++ +   A++++  +       L + E++    
Sbjct: 1495 EAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1553

Query: 71   RSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNET 130
            ++EVE+   ++ +LE     A  E    R +  E+ A+  R  ++     ++L+      
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR------ 1607

Query: 131  EKAFQTSQQKWKEECRRFEHDLE-ERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQR 189
            E+A + +QQ+ + E  R E + E ER  +  N      L  +E ++ +K+L +A  + Q+
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQK 1666

Query: 190  EKNEMESHIR----ETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEH 245
            E+ E E+  R    E A+ +  L E++ E +R+  +   Q++  A Q + +   + ETE 
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL--RAETEQ 1724

Query: 246  MDCS-DLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERA-AHLESKFNSEI 303
             +    LL  + + L+       + R+E EA   +VR   E + A +A A  ES+  SE 
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1784

Query: 304  IQLRIRDLEGALQ--VEKASQAEAVADLEIIKNEFKEVESAYER--------EKHNA--- 350
             + R+    G  +   E+A++  A+A+    + +  E ++A +R        EK  A   
Sbjct: 1785 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844

Query: 351  ---QESFAKLNLLEKEYFSKN-KKLNEDIEEQKKVIIDLSKRLQYN-EKSCSELQEELVM 405
                ++ A++ L EKE  ++  ++L ED   Q++ + + + + + + E+  ++L++    
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904

Query: 406  AKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDY 465
              + Q  LVE      +++E  + +   S        K         + L R+R    D 
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKAS------FEKAAAGKAELELELGRIRSNAEDT 1958

Query: 466  QNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREAL-- 523
                E A  E     +L + +++        +E +++   V K L+        R+A   
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEER------RRREAEER---VQKSLAAEEEAARQRKAALE 2009

Query: 524  -ISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHK--DAEEKLTFLHTLYQHLVAG 580
             +  LK +++      E+ + ++A+   +LQ   +A  K   AEEK      + Q     
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESAR---QLQLAQEAAQKRLQAEEK-AHAFAVQQKEQEL 2065

Query: 581  CVLIKQPEGMLDKFSWSELCA--VLQENVDALIADLNRANEKIRHLEYICKNKSDTMREL 638
               ++Q + +LD+       A    +E  +A +     A +  R +E   + K     + 
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125

Query: 639  Q-----QTQEDTFTKVAEQIKA------QESCWHRQKKELELQYSELFLE--VQKRAQKF 685
            Q     Q   +   K AEQ  A      Q +   +Q  + E++  + F E  ++++AQ  
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185

Query: 686  QEIA------EKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALY 739
            QE+       E+   + N +++  ++L  E +   +  SQ + E  S+      ++    
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245

Query: 740  PLYSRSCAL------STQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKT 793
             + + + AL      +TQR FLQE+         +++ +A+  + +    QE A++++  
Sbjct: 2246 RIEAENRALILRDKDNTQR-FLQEEAE-------KMKQVAEEAARLSVAAQEAARLRQLA 2297

Query: 794  FKGLI-------RIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQD 846
             + L        ++ ++ + AV  A RLK    + A L    +   +     +   + Q 
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLK----AEAELLQQQKELAQEQARRLQEDKEQM 2353

Query: 847  KHKFPKHQKEQLRCLQA-----LSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLL 901
              +  +  +   R L+A     L     ++ L   ++ M+  Q    +A+ +++      
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQ------ 2404

Query: 902  IGAAKNSFAKLMDKISLVMECIPLHSSRSITYVE--------KDSLVQRLAHGLHKVNTL 953
                   F K  ++I   +    L +   +T V+         D   +RL   + ++   
Sbjct: 2405 ------RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2458

Query: 954  ALKYGLRGHVPITKSTASL---QKQILGFTQRLHAAEVERRSLRLEVTEF----KRSVNE 1006
              K      +   KS       Q+Q+L  TQ L  + +  +   L+   F    K  + +
Sbjct: 2459 KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2518

Query: 1007 M-KKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQE 1065
            + + E+ KAQ L+ +    +Q      ++  ++ EE   A  R+ +A+  +  + ++LQ+
Sbjct: 2519 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEELQQ 2575

Query: 1066 LNYKLELHSSEEADKNQTLGEAVKSLSE 1093
            L  +        A++NQ L E ++ L E
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEE 2603



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 246/1251 (19%), Positives = 495/1251 (39%), Gaps = 165/1251 (13%)

Query: 3    LNTSSNTGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELAS 62
            L  SS      + + A    +  L+ E E+ +   +R +L   ++++     +  A  A 
Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRV---VRLQLEATERQRGGAEGELQALRAR 1481

Query: 63   YESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSE 122
             E   A+ R   E+ E LR+ ++ D +  +++A +   +  +  AEA R +++      E
Sbjct: 1482 AEEAEAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540

Query: 123  LQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKS-RLEKTLQ 181
            L+ +  E E+  + ++    E  R+ +  LE      +   +       EK+ +LE++LQ
Sbjct: 1541 LRLQAEEAERRLRQAEV---ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597

Query: 182  E-----ALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRE-LQFIVQEQDTAVQNMH 235
            E     A  + + E+   +    E A EE   + E+W+ +  E L+  +Q ++ A Q   
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ--- 1654

Query: 236  KKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKL-EENIE-----A 289
            K + + E E         +Q  E E    RE R R + E   +R R+L E+ +E     A
Sbjct: 1655 KSLAQAEAE---------KQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQLA 1701

Query: 290  ERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHN 349
            E  A        E+I+LR        + E+  Q   + + E+ + + +   +  +R++  
Sbjct: 1702 EGTAQQRLAAEQELIRLR-------AETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754

Query: 350  AQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVM---- 405
            A+   AK+   E E    +K   E  EE +       +RL+       EL EE       
Sbjct: 1755 AE--LAKVR-AEMEVLLASKARAE--EESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809

Query: 406  ---AKKHQAFLVETCENNVKELESIL-DSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRT 461
               AK+ +    E       E E +L +     G+ T    + +          ERLRR 
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869

Query: 462  LTD---YQNKLEDASNEEKA-------------CNELDSTKQKIDSHTKNIKELQDKLAD 505
              D    + +LE+ + + KA              +EL+  K  ++   +  +++++++  
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929

Query: 506  VNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEE 565
            +           A+ E  +  ++   ++ L   E+ + +AA+ + +L    +   ++AEE
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQLAAEEERRRREAEE 1988

Query: 566  KLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLE 625
            +      + + L A     +Q +  L++           E + A + +  R  E+     
Sbjct: 1989 R------VQKSLAAEEEAARQRKAALEEV----------ERLKAKVEEARRLRERA---- 2028

Query: 626  YICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELE--LQYSELFL-EVQKRA 682
                 + ++ R+LQ  QE    ++  + KA      ++++EL+  LQ  +  L +++  A
Sbjct: 2029 -----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083

Query: 683  QKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLY 742
            +  +  AE+  E     E+   Q   +    ++ L Q+  EQ    A     A  L    
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKLRKEA 2142

Query: 743  SRSCALSTQRD---FLQEQVNTFELFKLE------IRTLAQA---LSTVEEKKQEEAKMK 790
             +  A   Q +     Q+Q    E+ K +      +R  AQ    L+T+  + +E    K
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2202

Query: 791  KKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKF 850
                + L R+  +   A  AA +   + +   S+   ME     +  L    E +++   
Sbjct: 2203 NLLDEELQRLKAE---ATEAARQRSQVEEELFSVRVQMEE----LSKLKARIEAENRALI 2255

Query: 851  PKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFA 910
             + +    R LQ       ++ +  +    A L     +A    ++    L      +  
Sbjct: 2256 LRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2310

Query: 911  KLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVN---TLALKYGLRGHVPITK 967
             L +K+  V E   L +   +   +K+ L Q  A  L +        L    +G     +
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKE-LAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2369

Query: 968  STASLQKQILGFTQR--LHAAEVERRSLRLE--VTEFKRSVNEMKKELDKAQGLQMQLNE 1023
            +    Q ++    +R  L  AE+ R   R E     F++   E+ ++L + +    +   
Sbjct: 2370 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2429

Query: 1024 FKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEE-ADKNQ 1082
              Q+  I  ++ +   E L  A+   E+ +  L ++A+ LQ  + +++    E+   + Q
Sbjct: 2430 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489

Query: 1083 TLGEAVKSLSEAKMELRR------------------KDQSLR-QLNRHLTQLEQDKRRLE 1123
             L ++  S  ++ ++  R                  K Q LR +  R   Q+EQ+++RL 
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549

Query: 1124 ENI-------HDAESALRMAAKDKECVANHMRAVENTL----HKVRDQISL 1163
             ++       H+AE  +R   ++ + +    R  E  L     ++R+Q+ L
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2600



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 256/1253 (20%), Positives = 487/1253 (38%), Gaps = 192/1253 (15%)

Query: 47   KEKLEITTKHNAELASYESQIAKL------RSEVEKGEALRQSLEYDLAVARKEAGLGRR 100
            +E +++ T H +EL +  SQ  K       R E E+  A +Q  E    +A  EA L + 
Sbjct: 1314 QEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK- 1371

Query: 101  AAEERLAEAHRIQEKLCAQNS--ELQAKTNET-----EKAFQTSQQKW--KEECRRFEHD 151
              + +LAEAH  Q K  A+    ELQ +  E      E A    QQK   +EE ++    
Sbjct: 1372 --QRQLAEAHA-QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1428

Query: 152  LEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEE 211
             E     IQ   R+ +   + + R+E+ ++  + + Q E  E +    E  L+  R + E
Sbjct: 1429 SEAE---IQAKARQAEAAERSRLRIEEEIR--VVRLQLEATERQRGGAEGELQALRARAE 1483

Query: 212  QWEAERRELQ-----FIVQEQDTAVQNMHKKVE---KLETEHMDCSDLLRRQTSELEFST 263
            + EA++R+ Q        Q QD + +    +VE   +++ E     +  R   +  E   
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543

Query: 264  QREERLRKEFEATTLRVRKLEENIE-----------------AERAAHLESKFNSE---I 303
            Q EE  R+  +A   R R+++  +E                 AE+ A LE     E   +
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603

Query: 304  IQLR--------------------IRDLEG-----------ALQVEKASQAEAVADLEII 332
             QLR                     R+LE             LQ E+ +Q +++A  E  
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663

Query: 333  KNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQK----KVIIDLSKR 388
            K   KE      R +  A+E   +   L ++   K ++L E   +Q+    + +I L   
Sbjct: 1664 KQ--KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1721

Query: 389  LQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTV--------SGQWTSG 440
             +  E+    L+EEL   ++  A   +  +    EL  +     V          +  S 
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781

Query: 441  IHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQ 500
              K K +  + +     L       +   E+A  + +   E D+ +Q+ ++     + L 
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQRAEAE----RVLA 1836

Query: 501  DKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFH 560
            +KLA +  E + L T   + E  +   + E + +    E E  Q  + E +      A H
Sbjct: 1837 EKLAAIG-EATRLKT---EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ-----AAQH 1887

Query: 561  K-DAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANE 619
            K D EE+L  L        A    +++ +G+++          ++E + AL A   +A  
Sbjct: 1888 KADIEERLAQLRK------ASDSELERQKGLVEDTLRQR--RQVEEEILALKASFEKAAA 1939

Query: 620  KIRHLEY----ICKNKSDTMRELQQTQ-----------------EDTFTKVAEQIKAQES 658
                LE     I  N  DT+R  +Q +                  +   +V + + A+E 
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999

Query: 659  CWHRQKKELELQYSELFLEV-----------QKRAQKFQEIAEKNMEKLNHIEKSHEQLV 707
               ++K  LE +   L  +V           Q+ A++ Q   E   ++L   EK+H   V
Sbjct: 2000 AARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2058

Query: 708  LENSHFKKLLSQTQREQMSLLAACALMAGALYPL--YSRSCALSTQRDFLQEQVNTFELF 765
             +    ++ L QT +++ S+L      A A       +    +  +R+  Q +    E  
Sbjct: 2059 QQK---EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2115

Query: 766  KL------EIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQ 819
            +L      + +  AQA +  E+ ++E  +   +  +      R+   A     + K   +
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2175

Query: 820  SCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTS-SDLLAAIIS 878
                    +E     + + +   + Q      + Q+ +    +A    +   + L ++  
Sbjct: 2176 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235

Query: 879  SMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSR-SITYVEKD 937
             M EL  +  + +  +R     LI   K++  + + + +  M+ +   ++R S+   E  
Sbjct: 2236 QMEELSKLKARIEAENR----ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2291

Query: 938  SLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEV 997
             L Q     L +   LA K  L+  +   +    L+ +     Q+   A+ + R L+ + 
Sbjct: 2292 RLRQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2350

Query: 998  TEFKRSVNEMKKELDKAQGLQMQLNEFKQSKL---ITHEKFESACEELNNALLREEQAQM 1054
             +  + + E      + QG Q  L   +Q +L      E+ +    E++ A  R E+   
Sbjct: 2351 EQMAQQLAE------ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404

Query: 1055 LLNEQAQQLQELNYKLELHSSEEADKNQTL-------GEAVKSLSEAKMELRRKDQSLRQ 1107
               +QA+++ E  ++ EL + E+    QTL           + L EA  EL R+ + L+Q
Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464

Query: 1108 LNRHLTQLEQDKRRL---EENIHDAESALRMAAKDKECVANHMRAVENTLHKV 1157
                L QL+ ++ +    E+ + + ++  +    +K+ +    R +E    K+
Sbjct: 2465 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 210/1134 (18%), Positives = 444/1134 (39%), Gaps = 161/1134 (14%)

Query: 59   ELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCA 118
            EL + ++ + KLR++ E  +    +L  +L  A++     ++   ER  E  R +E++  
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLL--------- 169
                 QA   +T+   Q   ++   + R +    +     +Q+  R  + +         
Sbjct: 1184 LLERWQAVLAQTDVR-QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242

Query: 170  -MKEKSRLEKTLQEALEKHQREKNEMESHIRE--TALEEFRLQEEQWEAERRELQFIVQE 226
             ++E+ R E+ L E +E+H  +  E +   ++   A++++ LQ   ++A+   +    ++
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1302

Query: 227  QDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEEN 286
                   +    E +  E++D    LR   SEL                TTL  + +   
Sbjct: 1303 P-----KVQSGSESVIQEYVD----LRTHYSEL----------------TTLTSQYI--- 1334

Query: 287  IEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYERE 346
                       KF SE ++ R+ + E   + ++A + E +A++E    + +++  A+ + 
Sbjct: 1335 -----------KFISETLR-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1382

Query: 347  KHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMA 406
            K  A+    +L    +E   + ++   D ++QK+ I +  ++L+ +        E  + A
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS-------EAEIQA 1435

Query: 407  KKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQ 466
            K  QA   E     ++E                             + + RL+   T+ Q
Sbjct: 1436 KARQAEAAERSRLRIEE----------------------------EIRVVRLQLEATERQ 1467

Query: 467  NKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALIST 526
                +   +       ++  QK  +  +  + L+ ++ D ++       + A R    + 
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526

Query: 527  LKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKL-TFLHTLYQHLVAGCVLIK 585
               E Q  L   E+ + QA ++E  L++      +  +  L T   +    L +      
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1586

Query: 586  QPEGMLDKFSWSELCAVLQENVDA-----LIADLNRANEKI-RHLEYICKNKSDTMRELQ 639
            +    L++    E  AV Q   +A       A+  RA E+  R LE      ++ +R   
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1646

Query: 640  QTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHI 699
            Q +E     VA+Q    ++   +QK+E E +      + +++A + +E+AE+ +EK   +
Sbjct: 1647 QAEE-----VAQQKSLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQL 1700

Query: 700  -EKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQ 758
             E + +Q +       +L ++T++ +        L+   L  L   + A + +R  L+ +
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQR----QLLEEELARLQREAAAATQKRQELEAE 1756

Query: 759  VNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILG 818
            +      + E+  L  + +  EE+ +  ++  K+  +               A R + L 
Sbjct: 1757 LAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEA-------------EAGRFRELA 1800

Query: 819  QSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCL-QALSWLTSSDLLAAII 877
            +  A L    E  K     L      + + +  +   E+L  + +A    T +++  A+ 
Sbjct: 1801 EEAARLRALAEEAKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI--ALK 1857

Query: 878  SSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKD 937
               AE + +   A+  +     L   AA++  A + ++++ + +       R    VE D
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVE-D 1915

Query: 938  SLVQRLAHGLHKVNTLALKYGLR----GHVPITKSTASLQKQILGFTQRLHAAEVERRSL 993
            +L QR      +   LALK        G   +      ++       +    AE+E    
Sbjct: 1916 TLRQRRQV---EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972

Query: 994  RLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQ 1053
            R    E +R   E ++ + K+   + +    +++ L   E+ ++  EE      R EQ  
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ-- 2030

Query: 1054 MLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLT 1113
                E A+QLQ         + E A K     E   + +     +++K+Q L+Q      
Sbjct: 2031 ----ESARQLQL--------AQEAAQKRLQAEEKAHAFA-----VQQKEQELQQT----- 2068

Query: 1114 QLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSA 1167
             L+Q++  L++   +AE+A R A + +E      R    +  +V +   L  SA
Sbjct: 2069 -LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 82/345 (23%), Positives = 157/345 (45%), Gaps = 35/345 (10%)

Query: 11   DTQRLKIASLDVKQILKNETELDITDN--LRKKLHWAKKEKLEITT--KHNAELASYESQ 66
            +  RL +A+ +  + L+   E D+     L +K+   K + ++  T  K  AEL   + +
Sbjct: 2279 EAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337

Query: 67   IAK--LRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQ 124
            +A+   R   E  E + Q L  +    ++     R+   E  AEA R++ ++ A+ S  Q
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV-AEMSRAQ 2396

Query: 125  AKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEAL 184
            A+  E  + F+   ++  E+  R E   +E+  ++Q      ++  ++     + L+EA+
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL----EIQRQQSDHDAERLREAI 2452

Query: 185  EKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQ----EQDTAVQNMH----- 235
             + +REK +++   +   L+   +Q  Q E   +E Q + Q    E+D+ +Q        
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2512

Query: 236  -KKVEKLETEHMDCSDLLR----RQTSELEFSTQR-----EERLRKEFEATTLRVRKLEE 285
              K+E+L  + +  +  LR    RQ  ++E   QR     EE  R++ EA     RK EE
Sbjct: 2513 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572

Query: 286  NIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLE 330
              + E+    + +  +E  Q R+R+    LQ+ +     A+A  E
Sbjct: 2573 LQQLEQQRRQQEELLAEENQ-RLRE---QLQLLEEQHRAALAHSE 2613



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 226/1124 (20%), Positives = 410/1124 (36%), Gaps = 178/1124 (15%)

Query: 143  EECRRFEHDLEE------RDNMIQNCNREYDLLMKEK-----SRLEKTLQEALEKHQREK 191
            EE R+  H LE       RD+         D LM E+     S   + L ++LE+  +E+
Sbjct: 920  EEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 979

Query: 192  NEMESHIRETALEEFRLQEEQWEAER-------------RELQFIVQEQDTA---VQNMH 235
            +  +  I E  L++ RLQ E  E                RE    + EQ  A   V+ + 
Sbjct: 980  SRCQRCISE--LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG 1037

Query: 236  KKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHL 295
            K V +L  E          +   L   +     LR E E T   + KLE+ + +  A +L
Sbjct: 1038 KGVARLSAE--------AEKVLALPEPSPAAPTLRSELELT---LGKLEQ-VRSLSAIYL 1085

Query: 296  ESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFA 355
            E     + I L IR  +GA +V +A + E + + + +     E+E+         + S  
Sbjct: 1086 EKL---KTISLVIRGTQGAEEVLRAHE-EQLKEAQAVPATLPELEAT--------KASLK 1133

Query: 356  KLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELV-MAKKHQAFLV 414
            KL    +        L +++   ++V   L +R    +      +E +  + ++ QA L 
Sbjct: 1134 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1193

Query: 415  ET------CENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNK 468
            +T       E   ++L    +S    G W     + +++  +           L D Q  
Sbjct: 1194 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP---------LADSQAV 1244

Query: 469  LEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLK 528
             E    E+    E++   +K++   +  K+  + + D   +L               T K
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV--------------TYK 1290

Query: 529  VELQNVLHCWEKEKAQAAQSE------------SELQKLSQAFHKDAEEKLTFLHT---- 572
             +L+ V    +K K Q+                SEL  L+  + K   E L  +      
Sbjct: 1291 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1350

Query: 573  LYQHLVAGCVLIKQPEGMLDK---FSWSELCAVLQENVDALIADLNRANEKIRHLEYIC- 628
              Q        + + E  L+K    + +   A  Q   +A         E +R  E    
Sbjct: 1351 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1410

Query: 629  --KNKSDTMRELQQTQEDTFTKVAEQIKAQESCWH-RQKKELELQYSELFLEVQKRAQKF 685
              + K     ELQQ ++ +  ++  + +  E+    R + E E++   L LE  +R +  
Sbjct: 1411 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470

Query: 686  QEIAEKNMEKLN-HIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSR 744
               AE  ++ L    E++  Q        ++L  Q Q E      A   +A       SR
Sbjct: 1471 ---AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA-------SR 1520

Query: 745  SCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKG 804
              A +      Q  +   E  +L+     + L   E ++  + ++  +T +       + 
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-------RS 1573

Query: 805  VIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGE--PQDKHKFPKHQKE------ 856
              A L + R     +  A L   ++     +  L    E   Q + +  + ++E      
Sbjct: 1574 AEAELQSKRASF-AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 857  --QLRCLQALSWLTSSDLLA---AIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAK 911
              QL+  +AL     ++ +A   ++  + AE Q    + +   R       G A+    +
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAVR 1685

Query: 912  LMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLA-LKYGLRGHVPITKSTA 970
              +     +E       R +    + +  QRLA     +   A  + G +    + +  A
Sbjct: 1686 QRELAEQELE-----KQRQLA---EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737

Query: 971  SLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLI 1030
             LQ++    TQ+    E E   +R E+     S    ++E         Q  E +  +  
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF- 1796

Query: 1031 THEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKS 1090
              E  E A      A   + Q Q+   + A+Q  E    L       A+K   +GEA + 
Sbjct: 1797 -RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL-------AEKLAAIGEATRL 1848

Query: 1091 LSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENI--HDAESALRMA----AKDKECVA 1144
             +EA++ L+ K+    +L R        +RRLEE    H A+   R+A    A D E + 
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE-LE 1907

Query: 1145 NHMRAVENTLHKVRD--------QISLSWSAASRNDFTLQLPKL 1180
                 VE+TL + R         + S   +AA + +  L+L ++
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  103 bits (258), Expect = 8e-22
 Identities = 171/784 (21%), Positives = 324/784 (41%), Gaps = 86/784 (10%)

Query: 64   ESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSEL 123
            E ++ +LR+E E+GE  RQ LE +LA  ++EA    +  +E  AE  +++ ++    +  
Sbjct: 1680 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1739

Query: 124  QAKTNETEKAFQTSQQKWKEECRRFEHDLEERDN---MIQNCNREYDL----LMKEKSRL 176
                 E+    + S+Q+ + E  RF    EE      + +   R+  L      ++++  
Sbjct: 1740 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1799

Query: 177  EKTLQE---ALEKHQREKNEMESHIRETALEEFRLQE--EQWEAERRELQFIVQEQDTAV 231
            E+ L E   A+ +  R K E E  ++E   E  RL+   E    +RR L+    +    +
Sbjct: 1800 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1859

Query: 232  QNMHKKVEK-----LETEHMDCSDLL--RRQTSE----LEFSTQREERLRKEFEATTLRV 280
            +    ++ K     LE +     D L  RRQ  E    L+ S ++    + E E    R+
Sbjct: 1860 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1919

Query: 281  R-KLEENIEAERAAHLESKFNSEII---QLRIRDLEGALQVEKASQAEAV----ADLEII 332
            R   E+ + ++  A LE+    ++    + R R+ E  +Q   A++ EA     A LE +
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979

Query: 333  KNEFKEVESAYEREKHNAQESFAKLNLLEK---------------EYFSKNKKLNEDIEE 377
            +    +VE A    +   QES  +L L ++                   K ++L + +++
Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2039

Query: 378  QKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQW 437
            ++ V+  L    +   ++  E +E  V A++  A         V+E E +  S     Q 
Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA----QSRRQVEEAERLKQSAEEQAQA 2095

Query: 438  TSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIK 497
             +                E+LR+     Q     A  E+ A  +  +   +++ H K  +
Sbjct: 2096 RA----------QAQAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2143

Query: 498  ELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQ 557
            +   + A V +EL+ L  +  + +   + L  ELQ +    + E  +AA+  S++++   
Sbjct: 2144 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL----KAEATEAARQRSQVEEELF 2199

Query: 558  AFHKDAEEKLTFLHTLYQHLVA-GCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNR 616
            +     EE    L  L   + A    LI + +    +F   E  A   + V    A L+ 
Sbjct: 2200 SVRVQMEE----LSKLKARIEAENRALILRDKDNTQRFLQEE--AEKMKQVAEEAARLSV 2253

Query: 617  ANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKA-QESCWHRQKKELELQYSELF 675
            A ++   L  + +      R L +        + E+++A QE+   + + EL  Q  EL 
Sbjct: 2254 AAQEAARLRQLAEEDLAQQRALAEKM------LKEKMQAVQEATRLKAEAELLQQQKEL- 2306

Query: 676  LEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMA 735
               Q++A++ QE  E+  ++L   E    Q  LE    ++L    + E++ L    A M+
Sbjct: 2307 --AQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKL--RVAEMS 2361

Query: 736  GALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFK 795
             A       +     Q + + E+++  EL   E  TL Q L    ++   +A+  ++   
Sbjct: 2362 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2421

Query: 796  GLIR 799
             L R
Sbjct: 2422 ELER 2425



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 175/838 (20%), Positives = 345/838 (41%), Gaps = 117/838 (13%)

Query: 55   KHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARK-----EAGLGRRAAEERLAEA 109
            K  A  A  E ++ ++RS  E  + LR   + +L  AR+     E    RR AEER+ ++
Sbjct: 1904 KAAAGKAELELELGRIRSNAE--DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1961

Query: 110  HRIQEKLCAQNS-------ELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNC 162
               +E+   Q          L+AK  E  +  + ++Q   E  R+ +   E     +Q  
Sbjct: 1962 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ---ESARQLQLAQEAAQKRLQAE 2018

Query: 163  NREYDLLMKEKSR-LEKTLQEALEKHQREKNEMESHIRETA-LEEFRLQEEQWEAERRE- 219
             + +   +++K + L++TLQ+      + + E E+  R     EE R+Q E+  A+ R  
Sbjct: 2019 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2078

Query: 220  ------LQFIVQEQDTAVQNMHKKVEKLETE---------HMDCSDLLRRQTSELEFSTQ 264
                  L+   +EQ  A        EKL  E           + + L ++Q ++ E    
Sbjct: 2079 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2138

Query: 265  R---EERLRK----EFEATTLRVRK---------LEENI-----EAERAAHLESKFNSEI 303
            +   E+ LR+    E E TTLR++          L+E +     EA  AA   S+   E+
Sbjct: 2139 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2198

Query: 304  IQLRIRDLEGA---LQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLL 360
              +R++  E +    ++E  ++A  + D +   N  + ++   E+ K  A+E+ A+L++ 
Sbjct: 2199 FSVRVQMEELSKLKARIEAENRALILRDKD---NTQRFLQEEAEKMKQVAEEA-ARLSVA 2254

Query: 361  EKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENN 420
             +E     +   ED+ +Q+ +   + K      +  + L+ E  + ++ +    E     
Sbjct: 2255 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2314

Query: 421  VKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACN 480
             ++ E +        Q              F   LE  R      Q +LE ++  E+   
Sbjct: 2315 QEDKEQMAQQLAEETQ-------------GFQRTLEAER------QRQLEMSAEAERLKL 2355

Query: 481  ELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEK 540
             +    +      ++ +  + +  ++ ++L        ++  L+ TL+++ Q   H  E+
Sbjct: 2356 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2415

Query: 541  EKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELC 600
             +   A+ E E +KL Q      E KL  L +     V    L+++ + +   F  SE  
Sbjct: 2416 LREAIAELEREKEKLQQ------EAKLLQLKSEEMQTVQQEQLLQETQALQQSFL-SEKD 2468

Query: 601  AVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCW 660
            ++LQ         + +   K+  L      K+  +RE QQ Q+    +  +++ A     
Sbjct: 2469 SLLQRE-----RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523

Query: 661  HRQKKELE----LQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKL 716
             R++ E E     +  EL    Q+R Q+ + +AE+N       ++  EQL L     +  
Sbjct: 2524 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN-------QRLREQLQLLEEQHRAA 2576

Query: 717  LSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDF--LQEQVNTFELFKL------E 768
            L+ ++    S +AA   +      L   +     +  F  L+ +V+   L +       E
Sbjct: 2577 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2636

Query: 769  IRTLAQALSTVEE-KKQEEAK---MKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCA 822
            ++ LAQ  +TV+E  ++E+ +     + +  GL+       ++V AA + ++L    A
Sbjct: 2637 LQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTA 2694



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 235/1168 (20%), Positives = 491/1168 (42%), Gaps = 144/1168 (12%)

Query: 11   DTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKL 70
            + +RL+    D  Q  K + E+++   ++ +   A++++  +       L + E++    
Sbjct: 1463 EAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1521

Query: 71   RSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNET 130
            ++EVE+   ++ +LE     A  E    R +  E+ A+  R  ++     ++L+      
Sbjct: 1522 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR------ 1575

Query: 131  EKAFQTSQQKWKEECRRFEHDLE-ERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQR 189
            E+A + +QQ+ + E  R E + E ER  +  N      L  +E ++ +K+L +A  + Q+
Sbjct: 1576 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQK 1634

Query: 190  EKNEMESHIR----ETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEH 245
            E+ E E+  R    E A+ +  L E++ E +R+  +   Q++  A Q + +   + ETE 
Sbjct: 1635 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL--RAETEQ 1692

Query: 246  MDCS-DLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERA-AHLESKFNSEI 303
             +    LL  + + L+       + R+E EA   +VR   E + A +A A  ES+  SE 
Sbjct: 1693 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1752

Query: 304  IQLRIRDLEGALQ--VEKASQAEAVADLEIIKNEFKEVESAYER--------EKHNA--- 350
             + R+    G  +   E+A++  A+A+    + +  E ++A +R        EK  A   
Sbjct: 1753 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1812

Query: 351  ---QESFAKLNLLEKEYFSKN-KKLNEDIEEQKKVIIDLSKRLQYN-EKSCSELQEELVM 405
                ++ A++ L EKE  ++  ++L ED   Q++ + + + + + + E+  ++L++    
Sbjct: 1813 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1872

Query: 406  AKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDY 465
              + Q  LVE      +++E  + +   S        K         + L R+R    D 
Sbjct: 1873 ELERQKGLVEDTLRQRRQVEEEILALKAS------FEKAAAGKAELELELGRIRSNAEDT 1926

Query: 466  QNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREAL-- 523
                E A  E     +L + +++        +E +++   V K L+        R+A   
Sbjct: 1927 LRSKEQAELEAARQRQLAAEEER------RRREAEER---VQKSLAAEEEAARQRKAALE 1977

Query: 524  -ISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHK--DAEEKLTFLHTLYQHLVAG 580
             +  LK +++      E+ + ++A+   +LQ   +A  K   AEEK      + Q     
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESAR---QLQLAQEAAQKRLQAEEK-AHAFAVQQKEQEL 2033

Query: 581  CVLIKQPEGMLDKFSWSELCA--VLQENVDALIADLNRANEKIRHLEYICKNKSDTMREL 638
               ++Q + +LD+       A    +E  +A +     A +  R +E   + K     + 
Sbjct: 2034 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093

Query: 639  Q-----QTQEDTFTKVAEQIKA------QESCWHRQKKELELQYSELFLE--VQKRAQKF 685
            Q     Q   +   K AEQ  A      Q +   +Q  + E++  + F E  ++++AQ  
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2153

Query: 686  QEIA------EKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALY 739
            QE+       E+   + N +++  ++L  E +   +  SQ + E  S+      ++    
Sbjct: 2154 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2213

Query: 740  PLYSRSCAL------STQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKT 793
             + + + AL      +TQR FLQE+         +++ +A+  + +    QE A++++  
Sbjct: 2214 RIEAENRALILRDKDNTQR-FLQEEAE-------KMKQVAEEAARLSVAAQEAARLRQLA 2265

Query: 794  FKGLI-------RIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQD 846
             + L        ++ ++ + AV  A RLK    + A L    +   +     +   + Q 
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLK----AEAELLQQQKELAQEQARRLQEDKEQM 2321

Query: 847  KHKFPKHQKEQLRCLQA-----LSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLL 901
              +  +  +   R L+A     L     ++ L   ++ M+  Q    +A+ +++      
Sbjct: 2322 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQ------ 2372

Query: 902  IGAAKNSFAKLMDKISLVMECIPLHSSRSITYVE--------KDSLVQRLAHGLHKVNTL 953
                   F K  ++I   +    L +   +T V+         D   +RL   + ++   
Sbjct: 2373 ------RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2426

Query: 954  ALKYGLRGHVPITKSTASL---QKQILGFTQRLHAAEVERRSLRLEVTEF----KRSVNE 1006
              K      +   KS       Q+Q+L  TQ L  + +  +   L+   F    K  + +
Sbjct: 2427 KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2486

Query: 1007 M-KKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQE 1065
            + + E+ KAQ L+ +    +Q      ++  ++ EE   A  R+ +A+  +  + ++LQ+
Sbjct: 2487 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEELQQ 2543

Query: 1066 LNYKLELHSSEEADKNQTLGEAVKSLSE 1093
            L  +        A++NQ L E ++ L E
Sbjct: 2544 LEQQRRQQEELLAEENQRLREQLQLLEE 2571



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 246/1251 (19%), Positives = 495/1251 (39%), Gaps = 165/1251 (13%)

Query: 3    LNTSSNTGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELAS 62
            L  SS      + + A    +  L+ E E+ +   +R +L   ++++     +  A  A 
Sbjct: 1393 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRV---VRLQLEATERQRGGAEGELQALRAR 1449

Query: 63   YESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSE 122
             E   A+ R   E+ E LR+ ++ D +  +++A +   +  +  AEA R +++      E
Sbjct: 1450 AEEAEAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1508

Query: 123  LQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKS-RLEKTLQ 181
            L+ +  E E+  + ++    E  R+ +  LE      +   +       EK+ +LE++LQ
Sbjct: 1509 LRLQAEEAERRLRQAEV---ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1565

Query: 182  E-----ALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRE-LQFIVQEQDTAVQNMH 235
            E     A  + + E+   +    E A EE   + E+W+ +  E L+  +Q ++ A Q   
Sbjct: 1566 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ--- 1622

Query: 236  KKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKL-EENIE-----A 289
            K + + E E         +Q  E E    RE R R + E   +R R+L E+ +E     A
Sbjct: 1623 KSLAQAEAE---------KQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQLA 1669

Query: 290  ERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHN 349
            E  A        E+I+LR        + E+  Q   + + E+ + + +   +  +R++  
Sbjct: 1670 EGTAQQRLAAEQELIRLR-------AETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1722

Query: 350  AQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVM---- 405
            A+   AK+   E E    +K   E  EE +       +RL+       EL EE       
Sbjct: 1723 AE--LAKVR-AEMEVLLASKARAE--EESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1777

Query: 406  ---AKKHQAFLVETCENNVKELESIL-DSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRT 461
               AK+ +    E       E E +L +     G+ T    + +          ERLRR 
Sbjct: 1778 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1837

Query: 462  LTD---YQNKLEDASNEEKA-------------CNELDSTKQKIDSHTKNIKELQDKLAD 505
              D    + +LE+ + + KA              +EL+  K  ++   +  +++++++  
Sbjct: 1838 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1897

Query: 506  VNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEE 565
            +           A+ E  +  ++   ++ L   E+ + +AA+ + +L    +   ++AEE
Sbjct: 1898 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQLAAEEERRRREAEE 1956

Query: 566  KLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLE 625
            +      + + L A     +Q +  L++           E + A + +  R  E+     
Sbjct: 1957 R------VQKSLAAEEEAARQRKAALEEV----------ERLKAKVEEARRLRERA---- 1996

Query: 626  YICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELE--LQYSELFL-EVQKRA 682
                 + ++ R+LQ  QE    ++  + KA      ++++EL+  LQ  +  L +++  A
Sbjct: 1997 -----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051

Query: 683  QKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLY 742
            +  +  AE+  E     E+   Q   +    ++ L Q+  EQ    A     A  L    
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKLRKEA 2110

Query: 743  SRSCALSTQRD---FLQEQVNTFELFKLE------IRTLAQA---LSTVEEKKQEEAKMK 790
             +  A   Q +     Q+Q    E+ K +      +R  AQ    L+T+  + +E    K
Sbjct: 2111 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2170

Query: 791  KKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKF 850
                + L R+  +   A  AA +   + +   S+   ME     +  L    E +++   
Sbjct: 2171 NLLDEELQRLKAE---ATEAARQRSQVEEELFSVRVQMEE----LSKLKARIEAENRALI 2223

Query: 851  PKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFA 910
             + +    R LQ       ++ +  +    A L     +A    ++    L      +  
Sbjct: 2224 LRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2278

Query: 911  KLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVN---TLALKYGLRGHVPITK 967
             L +K+  V E   L +   +   +K+ L Q  A  L +        L    +G     +
Sbjct: 2279 MLKEKMQAVQEATRLKAEAELLQQQKE-LAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2337

Query: 968  STASLQKQILGFTQR--LHAAEVERRSLRLE--VTEFKRSVNEMKKELDKAQGLQMQLNE 1023
            +    Q ++    +R  L  AE+ R   R E     F++   E+ ++L + +    +   
Sbjct: 2338 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2397

Query: 1024 FKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEE-ADKNQ 1082
              Q+  I  ++ +   E L  A+   E+ +  L ++A+ LQ  + +++    E+   + Q
Sbjct: 2398 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2457

Query: 1083 TLGEAVKSLSEAKMELRR------------------KDQSLR-QLNRHLTQLEQDKRRLE 1123
             L ++  S  ++ ++  R                  K Q LR +  R   Q+EQ+++RL 
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517

Query: 1124 ENI-------HDAESALRMAAKDKECVANHMRAVENTL----HKVRDQISL 1163
             ++       H+AE  +R   ++ + +    R  E  L     ++R+Q+ L
Sbjct: 2518 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2568



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 256/1253 (20%), Positives = 487/1253 (38%), Gaps = 192/1253 (15%)

Query: 47   KEKLEITTKHNAELASYESQIAKL------RSEVEKGEALRQSLEYDLAVARKEAGLGRR 100
            +E +++ T H +EL +  SQ  K       R E E+  A +Q  E    +A  EA L + 
Sbjct: 1282 QEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK- 1339

Query: 101  AAEERLAEAHRIQEKLCAQNS--ELQAKTNET-----EKAFQTSQQKW--KEECRRFEHD 151
              + +LAEAH  Q K  A+    ELQ +  E      E A    QQK   +EE ++    
Sbjct: 1340 --QRQLAEAHA-QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1396

Query: 152  LEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEE 211
             E     IQ   R+ +   + + R+E+ ++  + + Q E  E +    E  L+  R + E
Sbjct: 1397 SEAE---IQAKARQAEAAERSRLRIEEEIR--VVRLQLEATERQRGGAEGELQALRARAE 1451

Query: 212  QWEAERRELQ-----FIVQEQDTAVQNMHKKVE---KLETEHMDCSDLLRRQTSELEFST 263
            + EA++R+ Q        Q QD + +    +VE   +++ E     +  R   +  E   
Sbjct: 1452 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1511

Query: 264  QREERLRKEFEATTLRVRKLEENIE-----------------AERAAHLESKFNSE---I 303
            Q EE  R+  +A   R R+++  +E                 AE+ A LE     E   +
Sbjct: 1512 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1571

Query: 304  IQLR--------------------IRDLEG-----------ALQVEKASQAEAVADLEII 332
             QLR                     R+LE             LQ E+ +Q +++A  E  
Sbjct: 1572 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1631

Query: 333  KNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQK----KVIIDLSKR 388
            K   KE      R +  A+E   +   L ++   K ++L E   +Q+    + +I L   
Sbjct: 1632 KQ--KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1689

Query: 389  LQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTV--------SGQWTSG 440
             +  E+    L+EEL   ++  A   +  +    EL  +     V          +  S 
Sbjct: 1690 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1749

Query: 441  IHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQ 500
              K K +  + +     L       +   E+A  + +   E D+ +Q+ ++     + L 
Sbjct: 1750 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQRAEAE----RVLA 1804

Query: 501  DKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFH 560
            +KLA +  E + L T   + E  +   + E + +    E E  Q  + E +      A H
Sbjct: 1805 EKLAAIG-EATRLKT---EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ-----AAQH 1855

Query: 561  K-DAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANE 619
            K D EE+L  L        A    +++ +G+++          ++E + AL A   +A  
Sbjct: 1856 KADIEERLAQLRK------ASDSELERQKGLVEDTLRQR--RQVEEEILALKASFEKAAA 1907

Query: 620  KIRHLEY----ICKNKSDTMRELQQTQ-----------------EDTFTKVAEQIKAQES 658
                LE     I  N  DT+R  +Q +                  +   +V + + A+E 
Sbjct: 1908 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967

Query: 659  CWHRQKKELELQYSELFLEV-----------QKRAQKFQEIAEKNMEKLNHIEKSHEQLV 707
               ++K  LE +   L  +V           Q+ A++ Q   E   ++L   EK+H   V
Sbjct: 1968 AARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2026

Query: 708  LENSHFKKLLSQTQREQMSLLAACALMAGALYPL--YSRSCALSTQRDFLQEQVNTFELF 765
             +    ++ L QT +++ S+L      A A       +    +  +R+  Q +    E  
Sbjct: 2027 QQK---EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2083

Query: 766  KL------EIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQ 819
            +L      + +  AQA +  E+ ++E  +   +  +      R+   A     + K   +
Sbjct: 2084 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2143

Query: 820  SCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTS-SDLLAAIIS 878
                    +E     + + +   + Q      + Q+ +    +A    +   + L ++  
Sbjct: 2144 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2203

Query: 879  SMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSR-SITYVEKD 937
             M EL  +  + +  +R     LI   K++  + + + +  M+ +   ++R S+   E  
Sbjct: 2204 QMEELSKLKARIEAENR----ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2259

Query: 938  SLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEV 997
             L Q     L +   LA K  L+  +   +    L+ +     Q+   A+ + R L+ + 
Sbjct: 2260 RLRQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2318

Query: 998  TEFKRSVNEMKKELDKAQGLQMQLNEFKQSKL---ITHEKFESACEELNNALLREEQAQM 1054
             +  + + E      + QG Q  L   +Q +L      E+ +    E++ A  R E+   
Sbjct: 2319 EQMAQQLAE------ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2372

Query: 1055 LLNEQAQQLQELNYKLELHSSEEADKNQTL-------GEAVKSLSEAKMELRRKDQSLRQ 1107
               +QA+++ E  ++ EL + E+    QTL           + L EA  EL R+ + L+Q
Sbjct: 2373 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2432

Query: 1108 LNRHLTQLEQDKRRL---EENIHDAESALRMAAKDKECVANHMRAVENTLHKV 1157
                L QL+ ++ +    E+ + + ++  +    +K+ +    R +E    K+
Sbjct: 2433 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2484



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 210/1134 (18%), Positives = 444/1134 (39%), Gaps = 161/1134 (14%)

Query: 59   ELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCA 118
            EL + ++ + KLR++ E  +    +L  +L  A++     ++   ER  E  R +E++  
Sbjct: 1092 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1151

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLL--------- 169
                 QA   +T+   Q   ++   + R +    +     +Q+  R  + +         
Sbjct: 1152 LLERWQAVLAQTDVR-QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1210

Query: 170  -MKEKSRLEKTLQEALEKHQREKNEMESHIRE--TALEEFRLQEEQWEAERRELQFIVQE 226
             ++E+ R E+ L E +E+H  +  E +   ++   A++++ LQ   ++A+   +    ++
Sbjct: 1211 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1270

Query: 227  QDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEEN 286
                   +    E +  E++D    LR   SEL                TTL  + +   
Sbjct: 1271 P-----KVQSGSESVIQEYVD----LRTHYSEL----------------TTLTSQYI--- 1302

Query: 287  IEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYERE 346
                       KF SE ++ R+ + E   + ++A + E +A++E    + +++  A+ + 
Sbjct: 1303 -----------KFISETLR-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1350

Query: 347  KHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMA 406
            K  A+    +L    +E   + ++   D ++QK+ I +  ++L+ +        E  + A
Sbjct: 1351 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS-------EAEIQA 1403

Query: 407  KKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQ 466
            K  QA   E     ++E                             + + RL+   T+ Q
Sbjct: 1404 KARQAEAAERSRLRIEE----------------------------EIRVVRLQLEATERQ 1435

Query: 467  NKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALIST 526
                +   +       ++  QK  +  +  + L+ ++ D ++       + A R    + 
Sbjct: 1436 RGGAEGELQALRARAEEAEAQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1494

Query: 527  LKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKL-TFLHTLYQHLVAGCVLIK 585
               E Q  L   E+ + QA ++E  L++      +  +  L T   +    L +      
Sbjct: 1495 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1554

Query: 586  QPEGMLDKFSWSELCAVLQENVDA-----LIADLNRANEKI-RHLEYICKNKSDTMRELQ 639
            +    L++    E  AV Q   +A       A+  RA E+  R LE      ++ +R   
Sbjct: 1555 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1614

Query: 640  QTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHI 699
            Q +E     VA+Q    ++   +QK+E E +      + +++A + +E+AE+ +EK   +
Sbjct: 1615 QAEE-----VAQQKSLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQL 1668

Query: 700  -EKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQ 758
             E + +Q +       +L ++T++ +        L+   L  L   + A + +R  L+ +
Sbjct: 1669 AEGTAQQRLAAEQELIRLRAETEQGEQQR----QLLEEELARLQREAAAATQKRQELEAE 1724

Query: 759  VNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILG 818
            +      + E+  L  + +  EE+ +  ++  K+  +               A R + L 
Sbjct: 1725 LAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEA-------------EAGRFRELA 1768

Query: 819  QSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCL-QALSWLTSSDLLAAII 877
            +  A L    E  K     L      + + +  +   E+L  + +A    T +++  A+ 
Sbjct: 1769 EEAARLRALAEEAKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI--ALK 1825

Query: 878  SSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKD 937
               AE + +   A+  +     L   AA++  A + ++++ + +       R    VE D
Sbjct: 1826 EKEAENERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVE-D 1883

Query: 938  SLVQRLAHGLHKVNTLALKYGLR----GHVPITKSTASLQKQILGFTQRLHAAEVERRSL 993
            +L QR      +   LALK        G   +      ++       +    AE+E    
Sbjct: 1884 TLRQRRQV---EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1940

Query: 994  RLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQ 1053
            R    E +R   E ++ + K+   + +    +++ L   E+ ++  EE      R EQ  
Sbjct: 1941 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ-- 1998

Query: 1054 MLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLT 1113
                E A+QLQ         + E A K     E   + +     +++K+Q L+Q      
Sbjct: 1999 ----ESARQLQL--------AQEAAQKRLQAEEKAHAFA-----VQQKEQELQQT----- 2036

Query: 1114 QLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSA 1167
             L+Q++  L++   +AE+A R A + +E      R    +  +V +   L  SA
Sbjct: 2037 -LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2089



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 82/345 (23%), Positives = 157/345 (45%), Gaps = 35/345 (10%)

Query: 11   DTQRLKIASLDVKQILKNETELDITDN--LRKKLHWAKKEKLEITT--KHNAELASYESQ 66
            +  RL +A+ +  + L+   E D+     L +K+   K + ++  T  K  AEL   + +
Sbjct: 2247 EAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2305

Query: 67   IAK--LRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQ 124
            +A+   R   E  E + Q L  +    ++     R+   E  AEA R++ ++ A+ S  Q
Sbjct: 2306 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV-AEMSRAQ 2364

Query: 125  AKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEAL 184
            A+  E  + F+   ++  E+  R E   +E+  ++Q      ++  ++     + L+EA+
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL----EIQRQQSDHDAERLREAI 2420

Query: 185  EKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQ----EQDTAVQNMH----- 235
             + +REK +++   +   L+   +Q  Q E   +E Q + Q    E+D+ +Q        
Sbjct: 2421 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2480

Query: 236  -KKVEKLETEHMDCSDLLR----RQTSELEFSTQR-----EERLRKEFEATTLRVRKLEE 285
              K+E+L  + +  +  LR    RQ  ++E   QR     EE  R++ EA     RK EE
Sbjct: 2481 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2540

Query: 286  NIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLE 330
              + E+    + +  +E  Q R+R+    LQ+ +     A+A  E
Sbjct: 2541 LQQLEQQRRQQEELLAEENQ-RLRE---QLQLLEEQHRAALAHSE 2581



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 226/1124 (20%), Positives = 410/1124 (36%), Gaps = 178/1124 (15%)

Query: 143  EECRRFEHDLEE------RDNMIQNCNREYDLLMKEK-----SRLEKTLQEALEKHQREK 191
            EE R+  H LE       RD+         D LM E+     S   + L ++LE+  +E+
Sbjct: 888  EEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 947

Query: 192  NEMESHIRETALEEFRLQEEQWEAER-------------RELQFIVQEQDTA---VQNMH 235
            +  +  I E  L++ RLQ E  E                RE    + EQ  A   V+ + 
Sbjct: 948  SRCQRCISE--LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG 1005

Query: 236  KKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHL 295
            K V +L  E          +   L   +     LR E E T   + KLE+ + +  A +L
Sbjct: 1006 KGVARLSAE--------AEKVLALPEPSPAAPTLRSELELT---LGKLEQ-VRSLSAIYL 1053

Query: 296  ESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFA 355
            E     + I L IR  +GA +V +A + E + + + +     E+E+         + S  
Sbjct: 1054 EKL---KTISLVIRGTQGAEEVLRAHE-EQLKEAQAVPATLPELEAT--------KASLK 1101

Query: 356  KLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELV-MAKKHQAFLV 414
            KL    +        L +++   ++V   L +R    +      +E +  + ++ QA L 
Sbjct: 1102 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1161

Query: 415  ET------CENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNK 468
            +T       E   ++L    +S    G W     + +++  +           L D Q  
Sbjct: 1162 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP---------LADSQAV 1212

Query: 469  LEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLK 528
             E    E+    E++   +K++   +  K+  + + D   +L               T K
Sbjct: 1213 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV--------------TYK 1258

Query: 529  VELQNVLHCWEKEKAQAAQSE------------SELQKLSQAFHKDAEEKLTFLHT---- 572
             +L+ V    +K K Q+                SEL  L+  + K   E L  +      
Sbjct: 1259 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1318

Query: 573  LYQHLVAGCVLIKQPEGMLDK---FSWSELCAVLQENVDALIADLNRANEKIRHLEYIC- 628
              Q        + + E  L+K    + +   A  Q   +A         E +R  E    
Sbjct: 1319 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1378

Query: 629  --KNKSDTMRELQQTQEDTFTKVAEQIKAQESCWH-RQKKELELQYSELFLEVQKRAQKF 685
              + K     ELQQ ++ +  ++  + +  E+    R + E E++   L LE  +R +  
Sbjct: 1379 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1438

Query: 686  QEIAEKNMEKLN-HIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSR 744
               AE  ++ L    E++  Q        ++L  Q Q E      A   +A       SR
Sbjct: 1439 ---AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA-------SR 1488

Query: 745  SCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKG 804
              A +      Q  +   E  +L+     + L   E ++  + ++  +T +       + 
Sbjct: 1489 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-------RS 1541

Query: 805  VIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGE--PQDKHKFPKHQKE------ 856
              A L + R     +  A L   ++     +  L    E   Q + +  + ++E      
Sbjct: 1542 AEAELQSKRASF-AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600

Query: 857  --QLRCLQALSWLTSSDLLA---AIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAK 911
              QL+  +AL     ++ +A   ++  + AE Q    + +   R       G A+    +
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAVR 1653

Query: 912  LMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLA-LKYGLRGHVPITKSTA 970
              +     +E       R +    + +  QRLA     +   A  + G +    + +  A
Sbjct: 1654 QRELAEQELE-----KQRQLA---EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1705

Query: 971  SLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLI 1030
             LQ++    TQ+    E E   +R E+     S    ++E         Q  E +  +  
Sbjct: 1706 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF- 1764

Query: 1031 THEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKS 1090
              E  E A      A   + Q Q+   + A+Q  E    L       A+K   +GEA + 
Sbjct: 1765 -RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL-------AEKLAAIGEATRL 1816

Query: 1091 LSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENI--HDAESALRMA----AKDKECVA 1144
             +EA++ L+ K+    +L R        +RRLEE    H A+   R+A    A D E + 
Sbjct: 1817 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE-LE 1875

Query: 1145 NHMRAVENTLHKVRD--------QISLSWSAASRNDFTLQLPKL 1180
                 VE+TL + R         + S   +AA + +  L+L ++
Sbjct: 1876 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1919


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  103 bits (258), Expect = 8e-22
 Identities = 171/784 (21%), Positives = 324/784 (41%), Gaps = 86/784 (10%)

Query: 64   ESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSEL 123
            E ++ +LR+E E+GE  RQ LE +LA  ++EA    +  +E  AE  +++ ++    +  
Sbjct: 1849 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1908

Query: 124  QAKTNETEKAFQTSQQKWKEECRRFEHDLEERDN---MIQNCNREYDL----LMKEKSRL 176
                 E+    + S+Q+ + E  RF    EE      + +   R+  L      ++++  
Sbjct: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968

Query: 177  EKTLQE---ALEKHQREKNEMESHIRETALEEFRLQE--EQWEAERRELQFIVQEQDTAV 231
            E+ L E   A+ +  R K E E  ++E   E  RL+   E    +RR L+    +    +
Sbjct: 1969 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 2028

Query: 232  QNMHKKVEK-----LETEHMDCSDLL--RRQTSE----LEFSTQREERLRKEFEATTLRV 280
            +    ++ K     LE +     D L  RRQ  E    L+ S ++    + E E    R+
Sbjct: 2029 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088

Query: 281  R-KLEENIEAERAAHLESKFNSEII---QLRIRDLEGALQVEKASQAEAV----ADLEII 332
            R   E+ + ++  A LE+    ++    + R R+ E  +Q   A++ EA     A LE +
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148

Query: 333  KNEFKEVESAYEREKHNAQESFAKLNLLEK---------------EYFSKNKKLNEDIEE 377
            +    +VE A    +   QES  +L L ++                   K ++L + +++
Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2208

Query: 378  QKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQW 437
            ++ V+  L    +   ++  E +E  V A++  A         V+E E +  S     Q 
Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA----QSRRQVEEAERLKQSAEEQAQA 2264

Query: 438  TSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIK 497
             +                E+LR+     Q     A  E+ A  +  +   +++ H K  +
Sbjct: 2265 RA----------QAQAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2312

Query: 498  ELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQ 557
            +   + A V +EL+ L  +  + +   + L  ELQ +    + E  +AA+  S++++   
Sbjct: 2313 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL----KAEATEAARQRSQVEEELF 2368

Query: 558  AFHKDAEEKLTFLHTLYQHLVA-GCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNR 616
            +     EE    L  L   + A    LI + +    +F   E  A   + V    A L+ 
Sbjct: 2369 SVRVQMEE----LSKLKARIEAENRALILRDKDNTQRFLQEE--AEKMKQVAEEAARLSV 2422

Query: 617  ANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKA-QESCWHRQKKELELQYSELF 675
            A ++   L  + +      R L +        + E+++A QE+   + + EL  Q  EL 
Sbjct: 2423 AAQEAARLRQLAEEDLAQQRALAEKM------LKEKMQAVQEATRLKAEAELLQQQKEL- 2475

Query: 676  LEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMA 735
               Q++A++ QE  E+  ++L   E    Q  LE    ++L    + E++ L    A M+
Sbjct: 2476 --AQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKL--RVAEMS 2530

Query: 736  GALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFK 795
             A       +     Q + + E+++  EL   E  TL Q L    ++   +A+  ++   
Sbjct: 2531 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2590

Query: 796  GLIR 799
             L R
Sbjct: 2591 ELER 2594



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 175/838 (20%), Positives = 345/838 (41%), Gaps = 117/838 (13%)

Query: 55   KHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARK-----EAGLGRRAAEERLAEA 109
            K  A  A  E ++ ++RS  E  + LR   + +L  AR+     E    RR AEER+ ++
Sbjct: 2073 KAAAGKAELELELGRIRSNAE--DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 2130

Query: 110  HRIQEKLCAQNS-------ELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNC 162
               +E+   Q          L+AK  E  +  + ++Q   E  R+ +   E     +Q  
Sbjct: 2131 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ---ESARQLQLAQEAAQKRLQAE 2187

Query: 163  NREYDLLMKEKSR-LEKTLQEALEKHQREKNEMESHIRETA-LEEFRLQEEQWEAERRE- 219
             + +   +++K + L++TLQ+      + + E E+  R     EE R+Q E+  A+ R  
Sbjct: 2188 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2247

Query: 220  ------LQFIVQEQDTAVQNMHKKVEKLETE---------HMDCSDLLRRQTSELEFSTQ 264
                  L+   +EQ  A        EKL  E           + + L ++Q ++ E    
Sbjct: 2248 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2307

Query: 265  R---EERLRK----EFEATTLRVRK---------LEENI-----EAERAAHLESKFNSEI 303
            +   E+ LR+    E E TTLR++          L+E +     EA  AA   S+   E+
Sbjct: 2308 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2367

Query: 304  IQLRIRDLEGA---LQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLL 360
              +R++  E +    ++E  ++A  + D +   N  + ++   E+ K  A+E+ A+L++ 
Sbjct: 2368 FSVRVQMEELSKLKARIEAENRALILRDKD---NTQRFLQEEAEKMKQVAEEA-ARLSVA 2423

Query: 361  EKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENN 420
             +E     +   ED+ +Q+ +   + K      +  + L+ E  + ++ +    E     
Sbjct: 2424 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2483

Query: 421  VKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACN 480
             ++ E +        Q              F   LE  R      Q +LE ++  E+   
Sbjct: 2484 QEDKEQMAQQLAEETQ-------------GFQRTLEAER------QRQLEMSAEAERLKL 2524

Query: 481  ELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEK 540
             +    +      ++ +  + +  ++ ++L        ++  L+ TL+++ Q   H  E+
Sbjct: 2525 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2584

Query: 541  EKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELC 600
             +   A+ E E +KL Q      E KL  L +     V    L+++ + +   F  SE  
Sbjct: 2585 LREAIAELEREKEKLQQ------EAKLLQLKSEEMQTVQQEQLLQETQALQQSFL-SEKD 2637

Query: 601  AVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCW 660
            ++LQ         + +   K+  L      K+  +RE QQ Q+    +  +++ A     
Sbjct: 2638 SLLQRE-----RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2692

Query: 661  HRQKKELE----LQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKL 716
             R++ E E     +  EL    Q+R Q+ + +AE+N       ++  EQL L     +  
Sbjct: 2693 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN-------QRLREQLQLLEEQHRAA 2745

Query: 717  LSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDF--LQEQVNTFELFKL------E 768
            L+ ++    S +AA   +      L   +     +  F  L+ +V+   L +       E
Sbjct: 2746 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2805

Query: 769  IRTLAQALSTVEE-KKQEEAK---MKKKTFKGLIRIFRKGVIAVLAANRLKILGQSCA 822
            ++ LAQ  +TV+E  ++E+ +     + +  GL+       ++V AA + ++L    A
Sbjct: 2806 LQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTA 2863



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 235/1168 (20%), Positives = 491/1168 (42%), Gaps = 144/1168 (12%)

Query: 11   DTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKL 70
            + +RL+    D  Q  K + E+++   ++ +   A++++  +       L + E++    
Sbjct: 1632 EAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1690

Query: 71   RSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNET 130
            ++EVE+   ++ +LE     A  E    R +  E+ A+  R  ++     ++L+      
Sbjct: 1691 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR------ 1744

Query: 131  EKAFQTSQQKWKEECRRFEHDLE-ERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQR 189
            E+A + +QQ+ + E  R E + E ER  +  N      L  +E ++ +K+L +A  + Q+
Sbjct: 1745 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQAEAEKQK 1803

Query: 190  EKNEMESHIR----ETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEH 245
            E+ E E+  R    E A+ +  L E++ E +R+  +   Q++  A Q + +   + ETE 
Sbjct: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL--RAETEQ 1861

Query: 246  MDCS-DLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERA-AHLESKFNSEI 303
             +    LL  + + L+       + R+E EA   +VR   E + A +A A  ES+  SE 
Sbjct: 1862 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1921

Query: 304  IQLRIRDLEGALQ--VEKASQAEAVADLEIIKNEFKEVESAYER--------EKHNA--- 350
             + R+    G  +   E+A++  A+A+    + +  E ++A +R        EK  A   
Sbjct: 1922 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1981

Query: 351  ---QESFAKLNLLEKEYFSKN-KKLNEDIEEQKKVIIDLSKRLQYN-EKSCSELQEELVM 405
                ++ A++ L EKE  ++  ++L ED   Q++ + + + + + + E+  ++L++    
Sbjct: 1982 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 2041

Query: 406  AKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDY 465
              + Q  LVE      +++E  + +   S        K         + L R+R    D 
Sbjct: 2042 ELERQKGLVEDTLRQRRQVEEEILALKAS------FEKAAAGKAELELELGRIRSNAEDT 2095

Query: 466  QNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREAL-- 523
                E A  E     +L + +++        +E +++   V K L+        R+A   
Sbjct: 2096 LRSKEQAELEAARQRQLAAEEER------RRREAEER---VQKSLAAEEEAARQRKAALE 2146

Query: 524  -ISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHK--DAEEKLTFLHTLYQHLVAG 580
             +  LK +++      E+ + ++A+   +LQ   +A  K   AEEK      + Q     
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESAR---QLQLAQEAAQKRLQAEEK-AHAFAVQQKEQEL 2202

Query: 581  CVLIKQPEGMLDKFSWSELCA--VLQENVDALIADLNRANEKIRHLEYICKNKSDTMREL 638
               ++Q + +LD+       A    +E  +A +     A +  R +E   + K     + 
Sbjct: 2203 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262

Query: 639  Q-----QTQEDTFTKVAEQIKA------QESCWHRQKKELELQYSELFLE--VQKRAQKF 685
            Q     Q   +   K AEQ  A      Q +   +Q  + E++  + F E  ++++AQ  
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322

Query: 686  QEIA------EKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALY 739
            QE+       E+   + N +++  ++L  E +   +  SQ + E  S+      ++    
Sbjct: 2323 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2382

Query: 740  PLYSRSCAL------STQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKT 793
             + + + AL      +TQR FLQE+         +++ +A+  + +    QE A++++  
Sbjct: 2383 RIEAENRALILRDKDNTQR-FLQEEAE-------KMKQVAEEAARLSVAAQEAARLRQLA 2434

Query: 794  FKGLI-------RIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQD 846
             + L        ++ ++ + AV  A RLK    + A L    +   +     +   + Q 
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLK----AEAELLQQQKELAQEQARRLQEDKEQM 2490

Query: 847  KHKFPKHQKEQLRCLQA-----LSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLL 901
              +  +  +   R L+A     L     ++ L   ++ M+  Q    +A+ +++      
Sbjct: 2491 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQ------ 2541

Query: 902  IGAAKNSFAKLMDKISLVMECIPLHSSRSITYVE--------KDSLVQRLAHGLHKVNTL 953
                   F K  ++I   +    L +   +T V+         D   +RL   + ++   
Sbjct: 2542 ------RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2595

Query: 954  ALKYGLRGHVPITKSTASL---QKQILGFTQRLHAAEVERRSLRLEVTEF----KRSVNE 1006
              K      +   KS       Q+Q+L  TQ L  + +  +   L+   F    K  + +
Sbjct: 2596 KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2655

Query: 1007 M-KKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQE 1065
            + + E+ KAQ L+ +    +Q      ++  ++ EE   A  R+ +A+  +  + ++LQ+
Sbjct: 2656 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGVRRKQEELQQ 2712

Query: 1066 LNYKLELHSSEEADKNQTLGEAVKSLSE 1093
            L  +        A++NQ L E ++ L E
Sbjct: 2713 LEQQRRQQEELLAEENQRLREQLQLLEE 2740



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 246/1251 (19%), Positives = 495/1251 (39%), Gaps = 165/1251 (13%)

Query: 3    LNTSSNTGDTQRLKIASLDVKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELAS 62
            L  SS      + + A    +  L+ E E+ +   +R +L   ++++     +  A  A 
Sbjct: 1562 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRV---VRLQLEATERQRGGAEGELQALRAR 1618

Query: 63   YESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSE 122
             E   A+ R   E+ E LR+ ++ D +  +++A +   +  +  AEA R +++      E
Sbjct: 1619 AEEAEAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1677

Query: 123  LQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKS-RLEKTLQ 181
            L+ +  E E+  + ++    E  R+ +  LE      +   +       EK+ +LE++LQ
Sbjct: 1678 LRLQAEEAERRLRQAEV---ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734

Query: 182  E-----ALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRE-LQFIVQEQDTAVQNMH 235
            E     A  + + E+   +    E A EE   + E+W+ +  E L+  +Q ++ A Q   
Sbjct: 1735 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ--- 1791

Query: 236  KKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKL-EENIE-----A 289
            K + + E E         +Q  E E    RE R R + E   +R R+L E+ +E     A
Sbjct: 1792 KSLAQAEAE---------KQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQLA 1838

Query: 290  ERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHN 349
            E  A        E+I+LR        + E+  Q   + + E+ + + +   +  +R++  
Sbjct: 1839 EGTAQQRLAAEQELIRLR-------AETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1891

Query: 350  AQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVM---- 405
            A+   AK+   E E    +K   E  EE +       +RL+       EL EE       
Sbjct: 1892 AE--LAKVR-AEMEVLLASKARAE--EESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1946

Query: 406  ---AKKHQAFLVETCENNVKELESIL-DSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRT 461
               AK+ +    E       E E +L +     G+ T    + +          ERLRR 
Sbjct: 1947 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 2006

Query: 462  LTD---YQNKLEDASNEEKA-------------CNELDSTKQKIDSHTKNIKELQDKLAD 505
              D    + +LE+ + + KA              +EL+  K  ++   +  +++++++  
Sbjct: 2007 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 2066

Query: 506  VNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEE 565
            +           A+ E  +  ++   ++ L   E+ + +AA+ + +L    +   ++AEE
Sbjct: 2067 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQLAAEEERRRREAEE 2125

Query: 566  KLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLE 625
            +      + + L A     +Q +  L++           E + A + +  R  E+     
Sbjct: 2126 R------VQKSLAAEEEAARQRKAALEEV----------ERLKAKVEEARRLRERA---- 2165

Query: 626  YICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELE--LQYSELFL-EVQKRA 682
                 + ++ R+LQ  QE    ++  + KA      ++++EL+  LQ  +  L +++  A
Sbjct: 2166 -----EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220

Query: 683  QKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLY 742
            +  +  AE+  E     E+   Q   +    ++ L Q+  EQ    A     A  L    
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKLRKEA 2279

Query: 743  SRSCALSTQRD---FLQEQVNTFELFKLE------IRTLAQA---LSTVEEKKQEEAKMK 790
             +  A   Q +     Q+Q    E+ K +      +R  AQ    L+T+  + +E    K
Sbjct: 2280 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2339

Query: 791  KKTFKGLIRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKF 850
                + L R+  +   A  AA +   + +   S+   ME     +  L    E +++   
Sbjct: 2340 NLLDEELQRLKAE---ATEAARQRSQVEEELFSVRVQMEE----LSKLKARIEAENRALI 2392

Query: 851  PKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFA 910
             + +    R LQ       ++ +  +    A L     +A    ++    L      +  
Sbjct: 2393 LRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2447

Query: 911  KLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVN---TLALKYGLRGHVPITK 967
             L +K+  V E   L +   +   +K+ L Q  A  L +        L    +G     +
Sbjct: 2448 MLKEKMQAVQEATRLKAEAELLQQQKE-LAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2506

Query: 968  STASLQKQILGFTQR--LHAAEVERRSLRLE--VTEFKRSVNEMKKELDKAQGLQMQLNE 1023
            +    Q ++    +R  L  AE+ R   R E     F++   E+ ++L + +    +   
Sbjct: 2507 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2566

Query: 1024 FKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEE-ADKNQ 1082
              Q+  I  ++ +   E L  A+   E+ +  L ++A+ LQ  + +++    E+   + Q
Sbjct: 2567 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2626

Query: 1083 TLGEAVKSLSEAKMELRR------------------KDQSLR-QLNRHLTQLEQDKRRLE 1123
             L ++  S  ++ ++  R                  K Q LR +  R   Q+EQ+++RL 
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686

Query: 1124 ENI-------HDAESALRMAAKDKECVANHMRAVENTL----HKVRDQISL 1163
             ++       H+AE  +R   ++ + +    R  E  L     ++R+Q+ L
Sbjct: 2687 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2737



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 256/1253 (20%), Positives = 487/1253 (38%), Gaps = 192/1253 (15%)

Query: 47   KEKLEITTKHNAELASYESQIAKL------RSEVEKGEALRQSLEYDLAVARKEAGLGRR 100
            +E +++ T H +EL +  SQ  K       R E E+  A +Q  E    +A  EA L + 
Sbjct: 1451 QEYVDLRT-HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK- 1508

Query: 101  AAEERLAEAHRIQEKLCAQNS--ELQAKTNET-----EKAFQTSQQKW--KEECRRFEHD 151
              + +LAEAH  Q K  A+    ELQ +  E      E A    QQK   +EE ++    
Sbjct: 1509 --QRQLAEAHA-QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1565

Query: 152  LEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEE 211
             E     IQ   R+ +   + + R+E+ ++  + + Q E  E +    E  L+  R + E
Sbjct: 1566 SEAE---IQAKARQAEAAERSRLRIEEEIR--VVRLQLEATERQRGGAEGELQALRARAE 1620

Query: 212  QWEAERRELQ-----FIVQEQDTAVQNMHKKVE---KLETEHMDCSDLLRRQTSELEFST 263
            + EA++R+ Q        Q QD + +    +VE   +++ E     +  R   +  E   
Sbjct: 1621 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1680

Query: 264  QREERLRKEFEATTLRVRKLEENIE-----------------AERAAHLESKFNSE---I 303
            Q EE  R+  +A   R R+++  +E                 AE+ A LE     E   +
Sbjct: 1681 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1740

Query: 304  IQLR--------------------IRDLEG-----------ALQVEKASQAEAVADLEII 332
             QLR                     R+LE             LQ E+ +Q +++A  E  
Sbjct: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800

Query: 333  KNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQK----KVIIDLSKR 388
            K   KE      R +  A+E   +   L ++   K ++L E   +Q+    + +I L   
Sbjct: 1801 KQ--KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1858

Query: 389  LQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFTV--------SGQWTSG 440
             +  E+    L+EEL   ++  A   +  +    EL  +     V          +  S 
Sbjct: 1859 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1918

Query: 441  IHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQ 500
              K K +  + +     L       +   E+A  + +   E D+ +Q+ ++     + L 
Sbjct: 1919 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQRAEAE----RVLA 1973

Query: 501  DKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFH 560
            +KLA +  E + L T   + E  +   + E + +    E E  Q  + E +      A H
Sbjct: 1974 EKLAAIG-EATRLKT---EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ-----AAQH 2024

Query: 561  K-DAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANE 619
            K D EE+L  L        A    +++ +G+++          ++E + AL A   +A  
Sbjct: 2025 KADIEERLAQLRK------ASDSELERQKGLVEDTLRQR--RQVEEEILALKASFEKAAA 2076

Query: 620  KIRHLEY----ICKNKSDTMRELQQTQ-----------------EDTFTKVAEQIKAQES 658
                LE     I  N  DT+R  +Q +                  +   +V + + A+E 
Sbjct: 2077 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136

Query: 659  CWHRQKKELELQYSELFLEV-----------QKRAQKFQEIAEKNMEKLNHIEKSHEQLV 707
               ++K  LE +   L  +V           Q+ A++ Q   E   ++L   EK+H   V
Sbjct: 2137 AARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2195

Query: 708  LENSHFKKLLSQTQREQMSLLAACALMAGALYPL--YSRSCALSTQRDFLQEQVNTFELF 765
             +    ++ L QT +++ S+L      A A       +    +  +R+  Q +    E  
Sbjct: 2196 QQK---EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2252

Query: 766  KL------EIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILGQ 819
            +L      + +  AQA +  E+ ++E  +   +  +      R+   A     + K   +
Sbjct: 2253 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2312

Query: 820  SCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTS-SDLLAAIIS 878
                    +E     + + +   + Q      + Q+ +    +A    +   + L ++  
Sbjct: 2313 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2372

Query: 879  SMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSR-SITYVEKD 937
             M EL  +  + +  +R     LI   K++  + + + +  M+ +   ++R S+   E  
Sbjct: 2373 QMEELSKLKARIEAENR----ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2428

Query: 938  SLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEV 997
             L Q     L +   LA K  L+  +   +    L+ +     Q+   A+ + R L+ + 
Sbjct: 2429 RLRQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK 2487

Query: 998  TEFKRSVNEMKKELDKAQGLQMQLNEFKQSKL---ITHEKFESACEELNNALLREEQAQM 1054
             +  + + E      + QG Q  L   +Q +L      E+ +    E++ A  R E+   
Sbjct: 2488 EQMAQQLAE------ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2541

Query: 1055 LLNEQAQQLQELNYKLELHSSEEADKNQTL-------GEAVKSLSEAKMELRRKDQSLRQ 1107
               +QA+++ E  ++ EL + E+    QTL           + L EA  EL R+ + L+Q
Sbjct: 2542 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2601

Query: 1108 LNRHLTQLEQDKRRL---EENIHDAESALRMAAKDKECVANHMRAVENTLHKV 1157
                L QL+ ++ +    E+ + + ++  +    +K+ +    R +E    K+
Sbjct: 2602 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2653



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 210/1134 (18%), Positives = 444/1134 (39%), Gaps = 161/1134 (14%)

Query: 59   ELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCA 118
            EL + ++ + KLR++ E  +    +L  +L  A++     ++   ER  E  R +E++  
Sbjct: 1261 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1320

Query: 119  QNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLL--------- 169
                 QA   +T+   Q   ++   + R +    +     +Q+  R  + +         
Sbjct: 1321 LLERWQAVLAQTDVR-QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1379

Query: 170  -MKEKSRLEKTLQEALEKHQREKNEMESHIRE--TALEEFRLQEEQWEAERRELQFIVQE 226
             ++E+ R E+ L E +E+H  +  E +   ++   A++++ LQ   ++A+   +    ++
Sbjct: 1380 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1439

Query: 227  QDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEEN 286
                   +    E +  E++D    LR   SEL                TTL  + +   
Sbjct: 1440 P-----KVQSGSESVIQEYVD----LRTHYSEL----------------TTLTSQYI--- 1471

Query: 287  IEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYERE 346
                       KF SE ++ R+ + E   + ++A + E +A++E    + +++  A+ + 
Sbjct: 1472 -----------KFISETLR-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1519

Query: 347  KHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMA 406
            K  A+    +L    +E   + ++   D ++QK+ I +  ++L+ +        E  + A
Sbjct: 1520 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS-------EAEIQA 1572

Query: 407  KKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQ 466
            K  QA   E     ++E                             + + RL+   T+ Q
Sbjct: 1573 KARQAEAAERSRLRIEE----------------------------EIRVVRLQLEATERQ 1604

Query: 467  NKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALIST 526
                +   +       ++  QK  +  +  + L+ ++ D ++       + A R    + 
Sbjct: 1605 RGGAEGELQALRARAEEAEAQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1663

Query: 527  LKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKL-TFLHTLYQHLVAGCVLIK 585
               E Q  L   E+ + QA ++E  L++      +  +  L T   +    L +      
Sbjct: 1664 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1723

Query: 586  QPEGMLDKFSWSELCAVLQENVDA-----LIADLNRANEKI-RHLEYICKNKSDTMRELQ 639
            +    L++    E  AV Q   +A       A+  RA E+  R LE      ++ +R   
Sbjct: 1724 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL 1783

Query: 640  QTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHI 699
            Q +E     VA+Q    ++   +QK+E E +      + +++A + +E+AE+ +EK   +
Sbjct: 1784 QAEE-----VAQQKSLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQL 1837

Query: 700  -EKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQ 758
             E + +Q +       +L ++T++ +        L+   L  L   + A + +R  L+ +
Sbjct: 1838 AEGTAQQRLAAEQELIRLRAETEQGEQQR----QLLEEELARLQREAAAATQKRQELEAE 1893

Query: 759  VNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKGVIAVLAANRLKILG 818
            +      + E+  L  + +  EE+ +  ++  K+  +               A R + L 
Sbjct: 1894 LAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEA-------------EAGRFRELA 1937

Query: 819  QSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCL-QALSWLTSSDLLAAII 877
            +  A L    E  K     L      + + +  +   E+L  + +A    T +++  A+ 
Sbjct: 1938 EEAARLRALAEEAKRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI--ALK 1994

Query: 878  SSMAELQDVIGKADPNSRICGHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKD 937
               AE + +   A+  +     L   AA++  A + ++++ + +       R    VE D
Sbjct: 1995 EKEAENERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVE-D 2052

Query: 938  SLVQRLAHGLHKVNTLALKYGLR----GHVPITKSTASLQKQILGFTQRLHAAEVERRSL 993
            +L QR      +   LALK        G   +      ++       +    AE+E    
Sbjct: 2053 TLRQRRQV---EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 2109

Query: 994  RLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQ 1053
            R    E +R   E ++ + K+   + +    +++ L   E+ ++  EE      R EQ  
Sbjct: 2110 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ-- 2167

Query: 1054 MLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLT 1113
                E A+QLQ         + E A K     E   + +     +++K+Q L+Q      
Sbjct: 2168 ----ESARQLQL--------AQEAAQKRLQAEEKAHAFA-----VQQKEQELQQT----- 2205

Query: 1114 QLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSA 1167
             L+Q++  L++   +AE+A R A + +E      R    +  +V +   L  SA
Sbjct: 2206 -LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2258



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 82/345 (23%), Positives = 157/345 (45%), Gaps = 35/345 (10%)

Query: 11   DTQRLKIASLDVKQILKNETELDITDN--LRKKLHWAKKEKLEITT--KHNAELASYESQ 66
            +  RL +A+ +  + L+   E D+     L +K+   K + ++  T  K  AEL   + +
Sbjct: 2416 EAARLSVAAQEAAR-LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2474

Query: 67   IAK--LRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQ 124
            +A+   R   E  E + Q L  +    ++     R+   E  AEA R++ ++ A+ S  Q
Sbjct: 2475 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV-AEMSRAQ 2533

Query: 125  AKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEAL 184
            A+  E  + F+   ++  E+  R E   +E+  ++Q      ++  ++     + L+EA+
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL----EIQRQQSDHDAERLREAI 2589

Query: 185  EKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQ----EQDTAVQNMH----- 235
             + +REK +++   +   L+   +Q  Q E   +E Q + Q    E+D+ +Q        
Sbjct: 2590 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2649

Query: 236  -KKVEKLETEHMDCSDLLR----RQTSELEFSTQR-----EERLRKEFEATTLRVRKLEE 285
              K+E+L  + +  +  LR    RQ  ++E   QR     EE  R++ EA     RK EE
Sbjct: 2650 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2709

Query: 286  NIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLE 330
              + E+    + +  +E  Q R+R+    LQ+ +     A+A  E
Sbjct: 2710 LQQLEQQRRQQEELLAEENQ-RLRE---QLQLLEEQHRAALAHSE 2750



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 226/1124 (20%), Positives = 410/1124 (36%), Gaps = 178/1124 (15%)

Query: 143  EECRRFEHDLEE------RDNMIQNCNREYDLLMKEK-----SRLEKTLQEALEKHQREK 191
            EE R+  H LE       RD+         D LM E+     S   + L ++LE+  +E+
Sbjct: 1057 EEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 1116

Query: 192  NEMESHIRETALEEFRLQEEQWEAER-------------RELQFIVQEQDTA---VQNMH 235
            +  +  I E  L++ RLQ E  E                RE    + EQ  A   V+ + 
Sbjct: 1117 SRCQRCISE--LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG 1174

Query: 236  KKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHL 295
            K V +L  E          +   L   +     LR E E T   + KLE+ + +  A +L
Sbjct: 1175 KGVARLSAE--------AEKVLALPEPSPAAPTLRSELELT---LGKLEQ-VRSLSAIYL 1222

Query: 296  ESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFA 355
            E     + I L IR  +GA +V +A + E + + + +     E+E+         + S  
Sbjct: 1223 EKL---KTISLVIRGTQGAEEVLRAHE-EQLKEAQAVPATLPELEAT--------KASLK 1270

Query: 356  KLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELV-MAKKHQAFLV 414
            KL    +        L +++   ++V   L +R    +      +E +  + ++ QA L 
Sbjct: 1271 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1330

Query: 415  ET------CENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNK 468
            +T       E   ++L    +S    G W     + +++  +           L D Q  
Sbjct: 1331 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP---------LADSQAV 1381

Query: 469  LEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLK 528
             E    E+    E++   +K++   +  K+  + + D   +L               T K
Sbjct: 1382 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV--------------TYK 1427

Query: 529  VELQNVLHCWEKEKAQAAQSE------------SELQKLSQAFHKDAEEKLTFLHT---- 572
             +L+ V    +K K Q+                SEL  L+  + K   E L  +      
Sbjct: 1428 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1487

Query: 573  LYQHLVAGCVLIKQPEGMLDK---FSWSELCAVLQENVDALIADLNRANEKIRHLEYIC- 628
              Q        + + E  L+K    + +   A  Q   +A         E +R  E    
Sbjct: 1488 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1547

Query: 629  --KNKSDTMRELQQTQEDTFTKVAEQIKAQESCWH-RQKKELELQYSELFLEVQKRAQKF 685
              + K     ELQQ ++ +  ++  + +  E+    R + E E++   L LE  +R +  
Sbjct: 1548 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1607

Query: 686  QEIAEKNMEKLN-HIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSR 744
               AE  ++ L    E++  Q        ++L  Q Q E      A   +A       SR
Sbjct: 1608 ---AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA-------SR 1657

Query: 745  SCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFRKG 804
              A +      Q  +   E  +L+     + L   E ++  + ++  +T +       + 
Sbjct: 1658 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-------RS 1710

Query: 805  VIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGE--PQDKHKFPKHQKE------ 856
              A L + R     +  A L   ++     +  L    E   Q + +  + ++E      
Sbjct: 1711 AEAELQSKRASF-AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769

Query: 857  --QLRCLQALSWLTSSDLLA---AIISSMAELQDVIGKADPNSRICGHLLIGAAKNSFAK 911
              QL+  +AL     ++ +A   ++  + AE Q    + +   R       G A+    +
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------GKAEEQAVR 1822

Query: 912  LMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLA-LKYGLRGHVPITKSTA 970
              +     +E       R +    + +  QRLA     +   A  + G +    + +  A
Sbjct: 1823 QRELAEQELE-----KQRQLA---EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1874

Query: 971  SLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLI 1030
             LQ++    TQ+    E E   +R E+     S    ++E         Q  E +  +  
Sbjct: 1875 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF- 1933

Query: 1031 THEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKS 1090
              E  E A      A   + Q Q+   + A+Q  E    L       A+K   +GEA + 
Sbjct: 1934 -RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL-------AEKLAAIGEATRL 1985

Query: 1091 LSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENI--HDAESALRMA----AKDKECVA 1144
             +EA++ L+ K+    +L R        +RRLEE    H A+   R+A    A D E + 
Sbjct: 1986 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE-LE 2044

Query: 1145 NHMRAVENTLHKVRD--------QISLSWSAASRNDFTLQLPKL 1180
                 VE+TL + R         + S   +AA + +  L+L ++
Sbjct: 2045 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.127    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,688,254
Number of Sequences: 37866
Number of extensions: 1915408
Number of successful extensions: 21720
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 386
Number of HSP's successfully gapped in prelim test: 1043
Number of HSP's that attempted gapping in prelim test: 8687
Number of HSP's gapped (non-prelim): 7443
length of query: 1326
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1212
effective length of database: 13,930,794
effective search space: 16884122328
effective search space used: 16884122328
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.