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Search of human proteins with 38045896
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38045896 RAB6-interacting protein 2 isoform delta [Homo
sapiens]
(1088 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 2081 0.0
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 2066 0.0
gi|34577114 cytomatrix protein p110 [Homo sapiens] 1203 0.0
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 161 3e-39
gi|21735548 centrosomal protein 2 [Homo sapiens] 157 7e-38
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 154 4e-37
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 153 7e-37
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 149 2e-35
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 149 2e-35
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 149 2e-35
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 149 2e-35
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 149 2e-35
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 149 2e-35
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 148 3e-35
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 144 3e-34
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 144 6e-34
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 141 4e-33
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 141 4e-33
gi|148746195 trichohyalin [Homo sapiens] 140 9e-33
gi|156104908 myosin heavy chain 6 [Homo sapiens] 139 1e-32
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 139 1e-32
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 139 1e-32
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 138 2e-32
gi|38044112 restin isoform b [Homo sapiens] 137 6e-32
gi|4506751 restin isoform a [Homo sapiens] 137 6e-32
gi|71061468 centromere protein E [Homo sapiens] 137 7e-32
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 136 1e-31
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 135 2e-31
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 135 2e-31
gi|55770834 centromere protein F [Homo sapiens] 135 3e-31
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 2081 bits (5392), Expect = 0.0
Identities = 1088/1088 (100%), Positives = 1088/1088 (100%)
Query: 1 MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ 60
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ
Sbjct: 1 MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ 60
Query: 61 SLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVAS 120
SLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVAS
Sbjct: 61 SLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVAS 120
Query: 121 DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS 180
DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
Sbjct: 121 DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS 180
Query: 181 SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR 240
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR
Sbjct: 181 SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR 240
Query: 241 DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ 300
DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ
Sbjct: 241 DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ 300
Query: 301 TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML 360
TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
Sbjct: 301 TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML 360
Query: 361 REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE
Sbjct: 361 REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420
Query: 421 EEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE 480
EEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE
Sbjct: 421 EEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE 480
Query: 481 SLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV 540
SLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
Sbjct: 481 SLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV 540
Query: 541 KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT 600
KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT
Sbjct: 541 KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT 600
Query: 601 IERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 660
IERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS
Sbjct: 601 IERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 660
Query: 661 GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 720
GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK
Sbjct: 661 GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 720
Query: 721 DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSA 780
DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSA
Sbjct: 721 DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSA 780
Query: 781 QMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESART 840
QMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESART
Sbjct: 781 QMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESART 840
Query: 841 NAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQ 900
NAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQ
Sbjct: 841 NAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQ 900
Query: 901 EALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYE 960
EALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYE
Sbjct: 901 EALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYE 960
Query: 961 DDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPP 1020
DDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPP
Sbjct: 961 DDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPP 1020
Query: 1021 ASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQV 1080
ASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQV
Sbjct: 1021 ASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQV 1080
Query: 1081 VNALEESS 1088
VNALEESS
Sbjct: 1081 VNALEESS 1088
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
Length = 1116
Score = 2066 bits (5353), Expect = 0.0
Identities = 1088/1116 (97%), Positives = 1088/1116 (97%), Gaps = 28/1116 (2%)
Query: 1 MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ 60
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ
Sbjct: 1 MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ 60
Query: 61 SLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVAS 120
SLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVAS
Sbjct: 61 SLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVAS 120
Query: 121 DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS 180
DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
Sbjct: 121 DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS 180
Query: 181 SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR 240
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR
Sbjct: 181 SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR 240
Query: 241 DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ 300
DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ
Sbjct: 241 DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ 300
Query: 301 TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML 360
TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
Sbjct: 301 TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML 360
Query: 361 REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE
Sbjct: 361 REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420
Query: 421 EEMKQMEVYRSHSKFMKNK----------------------------IGQVKQELSRKDT 452
EEMKQMEVYRSHSKFMKNK IGQVKQELSRKDT
Sbjct: 421 EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDT 480
Query: 453 ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 512
ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
Sbjct: 481 ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 540
Query: 513 KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER 572
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER
Sbjct: 541 KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER 600
Query: 573 VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK 632
VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK
Sbjct: 601 VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK 660
Query: 633 VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA 692
VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
Sbjct: 661 VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA 720
Query: 693 HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 752
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA
Sbjct: 721 HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 780
Query: 753 ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 812
ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE
Sbjct: 781 ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 840
Query: 813 ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 872
ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ
Sbjct: 841 ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 900
Query: 873 SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA 932
SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA
Sbjct: 901 SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA 960
Query: 933 LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR 992
LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR
Sbjct: 961 LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR 1020
Query: 993 SKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGE 1052
SKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGE
Sbjct: 1021 SKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGE 1080
Query: 1053 RDNAELQEFANAILQQIADHCPDILEQVVNALEESS 1088
RDNAELQEFANAILQQIADHCPDILEQVVNALEESS
Sbjct: 1081 RDNAELQEFANAILQQIADHCPDILEQVVNALEESS 1116
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 1203 bits (3112), Expect = 0.0
Identities = 652/1003 (65%), Positives = 794/1003 (79%), Gaps = 77/1003 (7%)
Query: 1 MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ 60
MYGSAR++ +E S P RSPRLPRSPRLGHRRT+S GG GG+GKTLSMENIQ
Sbjct: 1 MYGSARTITNLEGS---PSRSPRLPRSPRLGHRRTSSGGG-------GGTGKTLSMENIQ 50
Query: 61 SLNAAYATSGPMYLSDHENVGSET-PKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVA 119
SLNAAYATSGPMYLSDHE V S T PK TMTLGR+ R YG R+TAMGSSPNIAS+G++
Sbjct: 51 SLNAAYATSGPMYLSDHEGVASTTYPKGTMTLGRATNRAVYGGRVTAMGSSPNIASAGLS 110
Query: 120 -SDTIAFGEHHLPPVSMAS----TVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEV 174
+D +++ + H + VP LRQ RD+T++DLQ QLKE+ RENDLLRK++++
Sbjct: 111 HTDVLSYTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDI 170
Query: 175 KESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQD 234
K+SKL SSMNSIKTFWSPELKKER LRK+EA+++++ KEQ RV EENQH+Q+TIQALQD
Sbjct: 171 KDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQD 230
Query: 235 ELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELR 294
ELR QRDLN L QQ+S +R E ELTEENF+RL AEH+RQAKELFLLRKTLEEMELR
Sbjct: 231 ELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELR 290
Query: 295 IETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKE 354
IETQKQTLNARDESIKKLLEMLQSKGL +K+ E+D+ERTRR+AEAE V HLE +L+QKE
Sbjct: 291 IETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKE 350
Query: 355 KENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGAL 414
KEN LREE+HRR + P+ AKTKALQTVIEMKD+KI+S+ER +RDLE+EIQMLK+NG L
Sbjct: 351 KENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVL 410
Query: 415 STEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH 474
+TE+REEE+KQ+EVY+SHSKFMK KI Q+KQELS+K++ELLALQTKLETL+NQ SD KQH
Sbjct: 411 NTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQH 470
Query: 475 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDL 534
IEVLKESLTAKEQRAAILQTEVDALRLRLEEKE+ LNKKTKQ+QD+ EEKGT AGEI D+
Sbjct: 471 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDM 530
Query: 535 KDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEAL 594
KDML+VKERK+NVLQKKIENLQEQLRDK+KQ+++LK+RVKSLQ D++NTDTAL TLEEAL
Sbjct: 531 KDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEAL 590
Query: 595 AEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHA 654
+EKER IERLKEQR+RD+RE+ EEI++++K+ KDLKEKV+ LQ +L+EKE+SL+DLKEHA
Sbjct: 591 SEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHA 650
Query: 655 SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLER 714
SSLAS+GLK+DS+LK+LEIA+EQKKEEC K+E+QLKKAH ++R +PE +D+I+ L++
Sbjct: 651 SSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDK 710
Query: 715 EITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE----RQVKDQNKKVANLKH 770
E + Y+DE KAQAEVDRLLEILKEVENEKNDKDKKIAELE R +KDQNKKVANLKH
Sbjct: 711 EASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKH 770
Query: 771 KEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQ-ITAERE 829
+Q+EKKK+AQ+LEE RRRED++ D+SQ LQ IEEL AL ++ Q + A +
Sbjct: 771 NQQLEKKKNAQLLEEVRRREDSMADNSQHLQ---------IEELMNALEKTRQELDATKA 821
Query: 830 MVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERR 889
+ + ++S AEK+ + +E+ KQ E ++ K + +++EK+ ++
Sbjct: 822 RLASTQQSL---AEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIA------- 871
Query: 890 KHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQ 949
+LE+ +S KKKTQEEV ALKREKDRLV QLKQQTQ
Sbjct: 872 -----LLELS--------------------ASKKKKTQEEVMALKREKDRLVHQLKQQTQ 906
Query: 950 NRMKLMADNYEDDHFKSSH------------SNQTNHKPSPDQ 980
NRMKLMADNY+DDH H S +NH+PSPDQ
Sbjct: 907 NRMKLMADNYDDDHHHYHHHHHHHHHRSPGRSQHSNHRPSPDQ 949
Score = 70.9 bits (172), Expect = 6e-12
Identities = 102/529 (19%), Positives = 228/529 (43%), Gaps = 50/529 (9%)
Query: 554 NLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDER 613
+LQ QL++ +++ L++ + + ++ ++ T +KER + +
Sbjct: 149 DLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRK---------- 198
Query: 614 EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI 673
E+ + K+ ++ E+ LQ + + L ++ L + + T+E+
Sbjct: 199 EEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIEL 258
Query: 674 ALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRL 733
E + L+ E ++A E L + EM RI+ +++ +DES K E+ +
Sbjct: 259 TEENFRR--LQAEHD-RQAKELFLLRKTLEEMELRIE-TQKQTLNARDESIKKLLEMLQS 314
Query: 734 LEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNL 793
+ + + N++ +++AE E QV + + + K KE + + EE RR
Sbjct: 315 KGLPSKSLEDDNERTRRMAEAESQVSHL-EVILDQKEKENIHLR------EELHRRSQLQ 367
Query: 794 ND--SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLM 851
+ ++ LQ + KD +I LE +R+ + E +M+ A + E++++++
Sbjct: 368 PEPAKTKALQTVIEMKDTKIASLERNIRD---LEDEIQMLKANGVLNTEDREEEIKQI-- 422
Query: 852 AMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQ--EALLAAISE 909
E K + MK K+ +Q L++KE+ L L+ + + + KQ E L +++
Sbjct: 423 --EVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTA 480
Query: 910 KDANIALLELSSSKKKTQ-EEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSH 968
K+ A+L+ + + EE + +K + +Q L ++ + D + K
Sbjct: 481 KEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERK 540
Query: 969 SNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDD 1028
N K + + + L + D+ + LK + L T + D + L++
Sbjct: 541 INVLQKKI--ENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALA---------TLEEA 589
Query: 1029 QAAWENELQKMTRGQLQD------ELEKGERDNAELQEFANAILQQIAD 1071
+ E ++++ + +D E+E ++N +L+E NA+ ++ +
Sbjct: 590 LSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTE 638
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 161 bits (408), Expect = 3e-39
Identities = 213/992 (21%), Positives = 433/992 (43%), Gaps = 134/992 (13%)
Query: 151 IMDLQTQLKEVLRENDLLRKDVEVKE--SKLSSSMNSIKTFWSPELKK-ERALRKDEASK 207
+ DLQ LKE ++ L+K++E + + + + + T S EL+ E+ L + +
Sbjct: 92 VQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTEN 151
Query: 208 ITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGE-----PCVAEL 262
I K+ + +++ + I ++ + +R L + +Q + T E + +L
Sbjct: 152 FNI-KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDL 210
Query: 263 TEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLS 322
E QR E ++ +L+K L +++ ++ E +K + LQS+ S
Sbjct: 211 KTELLQRPGIE------DVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYAS 264
Query: 323 AKAT--EEDHERTRRLAEAEMHVHHLESL------LEQKEK---ENSMLREEMHRRFE-- 369
++AT + E + E ++V L+ L L QK + EN + +E+ + + E
Sbjct: 265 SEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEK 324
Query: 370 NAPDSAKTKALQTVIEMKD-------SKISSMERGLRDLEEEIQMLKSNGALSTEEREEE 422
+ +S K +Q + KD S++S+ E L + E+ S +T++ +EE
Sbjct: 325 HNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL----SEKGEATQKLKEE 380
Query: 423 MKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDS----------- 471
+ ++E H +K + Q++Q+ K+ L LQ+++ L ++ ++
Sbjct: 381 LSEVETKYQH---LKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRL 437
Query: 472 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET-------MLNKKTKQIQDMAEEK 524
K+ ++ E L KEQ+ A LQ ++ L +L+EK T L+K +Q Q+ +
Sbjct: 438 KEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQ 497
Query: 525 GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 584
+ ++ + ++ L+ R++ +KI+NL+ L+ ++ +S L++ + L A +
Sbjct: 498 QSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGE 557
Query: 585 TALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKE 644
L + L EK T+ QE++ + LK+ E Q +L ++
Sbjct: 558 GETAVLNQ-LQEKNHTL--------------QEQVTQLTEKLKNQSESHKQAQENLHDQ- 601
Query: 645 ASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARA--S 702
+ + K H + L ++ + L L + KE+ +++ Q+K E L A A +
Sbjct: 602 --VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT 659
Query: 703 PEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQN 762
+ +D HL+ +D+ Q E++++ L +V + DK + ++LE +K+
Sbjct: 660 AQRADLQNHLDTAQNALQDK----QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYK 715
Query: 763 KKVANLKHK-EQVE---KKKSAQMLEEARRREDNLNDSSQQLQDS--------------- 803
+K +L+ K E++E KK A LE +E L D QQ Q +
Sbjct: 716 EKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLE 775
Query: 804 ------------LRKKDDRIEELEEAL---RESVQITAEREMVLAQEESAR-TNAEKQVE 847
L+KK + +E +++ L E QI + L+QE + +++
Sbjct: 776 MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQ 835
Query: 848 ELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAI 907
+ ++KVK E E++ +LS+ + L++ L N ++E K K +A + +
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE-----NQKGKAAILDL 890
Query: 908 SEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSS 967
EK +L + T +E LK+ ++ +++ +++KL ++ ++ ++
Sbjct: 891 -EKTCKELKHQLQVQMENTLKEQKELKKSLEK-----EKEASHQLKLELNSMQEQLIQAQ 944
Query: 968 HSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDD 1027
++ + N K Q+ + EL Q+ + K I L + +L+
Sbjct: 945 NTLKQNEK-EEQQLQGNINELKQSSEQKKKQI---EALQGELKIAVLQKTELENKLQQQL 1000
Query: 1028 DQAAWENELQKMTRGQLQDELEKGERDNAELQ 1059
QAA E +K LQ+ EK + +LQ
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQ 1032
Score = 147 bits (372), Expect = 4e-35
Identities = 195/954 (20%), Positives = 423/954 (44%), Gaps = 111/954 (11%)
Query: 143 LRQARDNTIMDLQTQLKEVLREN---DLLRKDVEVKE--SKLSSSMNSIKTFWSPELKKE 197
L++ +D T ++ + + V ++N L +KD++ ++ S+LS+S S+ +K
Sbjct: 312 LKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKG 371
Query: 198 RALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDE--------LRIQRDLNQLFQQ- 248
A +K KE+ V+ + QH++ + LQ + L++Q ++NQL +
Sbjct: 372 EATQK--------LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423
Query: 249 -DSSSRTGEPC--VAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
++ + GE + E + + ++L + ++ A L + E+++ ++ + +
Sbjct: 424 LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL 483
Query: 306 DESIKKLLE---MLQSKGLSAKATEEDHERT-RRLAEAEMHVHHLESLLEQKEKENSML- 360
D++ ++ E + QS + + D E+ R++ + + + +LE+LL QK KEN L
Sbjct: 484 DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL-QKSKENISLL 542
Query: 361 ---REEMHRRFENAP-DSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALST 416
RE+++ + + ++A LQ +++ + L++ E + + N
Sbjct: 543 EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV 602
Query: 417 EEREEEMKQME----VYRSHSKFMKNKIGQVKQELSRKDTELLA----LQTKLETLTNQF 468
+E++ ++ + + + +++ + K+++S+ D ++ A L + T Q
Sbjct: 603 QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
Query: 469 SDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAE-----E 523
+D + H++ + +L K+Q + T++D + +L++K+ ++ +++ E E
Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE 722
Query: 524 KGTQA--GEIHDLK-DMLDVKERKVNVLQ----KKIENLQEQLRDKE--KQMSSLKERVK 574
+ T+ G+I L+ D L+VK K LQ ++ N +LR E KQ+ KE V
Sbjct: 723 QKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 782
Query: 575 SLQADTTNTDTALTTLEEALAEKERTIERLK---EQRDRDEREKQEEIDN---------- 621
S + D AL ++++ L ++E + LK E ++ + + EE++N
Sbjct: 783 STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQ 842
Query: 622 -YKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSG----LKKDSRLKTLEIALE 676
K + + L ++S ++ LS+ SL + K G L + K L+ L+
Sbjct: 843 KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQ 902
Query: 677 QKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEI 736
+ E LK + +LKK+ E E AS ++ + ++ ++ + ++ + + E +L
Sbjct: 903 VQMENTLKEQKELKKSLEK--EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Query: 737 LKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDS 796
+ E++ K K+I L+ ++K + L++K Q + ++AQ L + + L ++
Sbjct: 961 INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 797 SQQLQDSLRKKDDRIEELEEALRESVQI--TAEREMVLAQE------------------- 835
++ Q++ ++ E L + Q + E ++ LAQE
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
Query: 836 -------ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAER 888
E E+Q++E A++ +++E + +L + + LAE E E
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
Query: 889 RKHLEEVLEMKQEALLAAISEKDANIAL----LELSSSKKKTQEEVAALKREKDRLVQQL 944
K EE+ K E++ + KDA L LEL + V KR + L Q+
Sbjct: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV 1200
Query: 945 KQQTQNRMKLMADNYEDDH--FKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLK 996
K++ + K + H K H+ + ++ + L++N +K
Sbjct: 1201 KKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVK 1254
Score = 140 bits (353), Expect = 7e-33
Identities = 197/929 (21%), Positives = 391/929 (42%), Gaps = 152/929 (16%)
Query: 127 EHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSI 186
+H L +L+Q+ + + Q L++VLR+ + ++ E+ L S +I
Sbjct: 480 QHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI 539
Query: 187 KTFWSPELKKERALRKDEASKITIWKEQYRVV---QEENQHMQMTIQALQDELRIQRDLN 243
L+KER +D +KI + + V+ QE+N +Q + L ++L+ Q + +
Sbjct: 540 SL-----LEKER---EDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESH 591
Query: 244 QLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLN 303
+ Q++ + + +E L A +R + L ++ E+ ++ K+ ++
Sbjct: 592 KQAQEN---------LHDQVQEQKAHLRAAQDR----VLSLETSVNELNSQLNESKEKVS 638
Query: 304 ARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREE 363
D IK E+L LSA+A +T + A+ + H+ ++ L+ K++E + + +
Sbjct: 639 QLDIQIKAKTELL----LSAEAA-----KTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689
Query: 364 MHRRFENAPDSAK-TKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEE 422
+ + D + L++ ++ K S+E+ +LE +I+ L+++ +E+
Sbjct: 690 LDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749
Query: 423 MKQMEVYRSHSKFMKNKIGQVKQELSRKDTEL---LALQTKLETLTN-QFSDSKQHIEVL 478
++ ++ R Q+ +L + TEL L ++ ++ + T + +E +
Sbjct: 750 LQDLQQQR-----------QLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798
Query: 479 KESLTAKEQRAAILQTEVDAL----RLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDL 534
K+ LT +E+ IL+ + + L +++ EE + ++Q + EK E+ +
Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTV 858
Query: 535 KDMLD-----VKERKVNV-------------LQKKIENLQEQLR-DKEKQMSSLKERVKS 575
KD L +K K L+K + L+ QL+ E + KE KS
Sbjct: 859 KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918
Query: 576 LQAD---TTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK 632
L+ + + L +++E L + + T++ Q +++E++ Q I+ K+ + K++
Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQNTLK----QNEKEEQQLQGNINELKQSSEQKKKQ 974
Query: 633 VSLLQGDL------------------SEKEASLLDLKEHASSLASSGLKKDSRLKTLEIA 674
+ LQG+L ++ L KE S L ++ K K L+
Sbjct: 975 IEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSD 1034
Query: 675 LEQKKEECLKMESQLKKAHEAALEARASPEMSDR---------IQHLEREITRYKDESSK 725
++ E L LK E L +S+R IQ L+ + +S+K
Sbjct: 1035 FYGRESELLATRQDLKSVEEK-LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAK 1093
Query: 726 AQAEVDRLLEILKEVENEKNDKDK-------KIAELERQVKDQNKKVANLKHKEQVEKKK 778
+ ++ + L++++ EK+ K+K K+AE+E Q K++ L + + K +
Sbjct: 1094 KEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLE 1153
Query: 779 SAQMLEEARRREDNLNDSSQQLQ---DSLRK------------KDDRIEELEEALRESVQ 823
S + + + + L +LQ DSL+ KD +E EE +E ++
Sbjct: 1154 SIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIE 1213
Query: 824 ITA-------EREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ---- 872
A E+E+ + + E Q+ L + VK+E +S + ++S ++
Sbjct: 1214 KEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDD 1273
Query: 873 ---SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEE 929
+A E + N + ERR LE L K E + + K +LEL T
Sbjct: 1274 LRGEIAVLEATVQNNQDERRALLERCL--KGEGEIEKLQTK-----VLELQRKLDNTTAA 1326
Query: 930 VAALKREKDRLVQQLKQQTQNRMKLMADN 958
V L RE L Q+K K DN
Sbjct: 1327 VQELGRENQSL--QIKHTQALNRKWAEDN 1353
Score = 135 bits (341), Expect = 2e-31
Identities = 176/759 (23%), Positives = 321/759 (42%), Gaps = 117/759 (15%)
Query: 233 QDELRIQRD----LNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTL 288
+ L ++RD L Q Q +S E +E ++ ++ +++AK L+ +
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 289 EEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKA------TEEDHERTRRLAEAEMH 342
E++ +E Q + + +IK++ ++ + K ++ D ER+ R A AE
Sbjct: 135 AELQ-SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA-AEQK 192
Query: 343 VHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLE 402
V L L ++ L+ E+ +R + K L V + D+ ER L+
Sbjct: 193 VTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLK 252
Query: 403 EEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLE 462
+E + L+S A S E + Q+ RS ++ QEL + + + L K +
Sbjct: 253 DECKKLQSQYASS----EATISQL---RSELAKGPQEVAVYVQELQKLKSSVNELTQKNQ 305
Query: 463 TLTNQFSDSKQHIEVLKE-----SLTAKEQRAAILQTEVDALRL--RLEEKETMLNKKTK 515
TLT +Q L+E S++ K +A + Q ++D +L RL ET L++
Sbjct: 306 TLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHV 365
Query: 516 QIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKS 575
++ + E TQ LK+ L E K L+ + + LQ+Q +KE+ L+ +
Sbjct: 366 ELSEKGE--ATQK-----LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQ 418
Query: 576 LQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 635
L + T E L E RLKEQR + E++ + ++ + DL+ K+S
Sbjct: 419 LHSKLLET-------ERQLGEAH---GRLKEQR----QLSSEKLMDKEQQVADLQLKLSR 464
Query: 636 LQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEA 695
L+ L EK + +L+ L+ +Q +E+ +S K EA
Sbjct: 465 LEEQLKEKVTNSTELQHQ-----------------LDKTKQQHQEQQALQQSTTAKLREA 507
Query: 696 ALE----ARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK---NDKD 748
+ R + +IQ+LE + + K+ S + E + L ++ E E N
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQ 567
Query: 749 KKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKD 808
+K L+ QV +K+ K Q E K AQ +NL+D Q+ + LR
Sbjct: 568 EKNHTLQEQVTQLTEKL-----KNQSESHKQAQ---------ENLHDQVQEQKAHLRAAQ 613
Query: 809 DRIEELEEALRE---------------SVQITAEREMVLAQE---ESARTNAEKQVEELL 850
DR+ LE ++ E +QI A+ E++L+ E + R + + ++
Sbjct: 614 DRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQ 673
Query: 851 MAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEK 910
A++ +QEL + +L L +K+ H + L + +++ E+ L ++Q+
Sbjct: 674 NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT-------- 725
Query: 911 DANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQ 949
EL KK + + +K K++ +Q L+QQ Q
Sbjct: 726 ------EELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 758
Score = 80.9 bits (198), Expect = 6e-15
Identities = 126/610 (20%), Positives = 267/610 (43%), Gaps = 98/610 (16%)
Query: 519 DMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLK---ERVKS 575
+ + G +G H + L +K V +L++++++LQ L++++ LK E+ +
Sbjct: 61 EAVHDAGNDSG--HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG 118
Query: 576 LQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 635
LQ D +T L E+ +E E Q E N K+ +KDL E+ +
Sbjct: 119 LQQQEAKPDGLVTDSSAELQSLEQQLE-----------EAQTENFNIKQ-MKDLFEQKA- 165
Query: 636 LQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEA 695
L+ + A + + SL + +K +RL EE K + ++
Sbjct: 166 --AQLATEIADIKSKYDEERSLREAAEQKVTRLT----------EELNKEATVIQDLKTE 213
Query: 696 ALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE 755
L+ +++ + L + T + + + + E ++L + K+++++ + I++L
Sbjct: 214 LLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLR 273
Query: 756 RQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELE 815
++ ++VA + ++++K KS+ + L +Q L ++L KK+ +LE
Sbjct: 274 SELAKGPQEVA--VYVQELQKLKSSV---------NELTQKNQTLTENLLKKEQDYTKLE 322
Query: 816 E------ALRESVQITAEREMVLAQEESARTNAEK--------QVEELLMAMEKVKQEL- 860
E ++++Q T ++ + Q+ +R +A + ++ E A +K+K+EL
Sbjct: 323 EKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS 382
Query: 861 ------ESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI 914
+ +KA+ QQ EKE H L++E + ++LE +++ A K+
Sbjct: 383 EVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR- 441
Query: 915 ALLELSSSKKKTQE-EVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTN 973
+LSS K +E +VA L+ + RL +QLK++ N +L ++ D K H Q
Sbjct: 442 ---QLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTEL---QHQLDKTKQQHQEQQA 495
Query: 974 HKPSP-----------DQIIQPLLELDQNRSKLKLYI----GHLTTLCHDRDPLILRGLT 1018
+ S +Q+++ + + DQ L+ + +++ L +R+ L
Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLY----- 550
Query: 1019 PPASYNLDDDQAAWENELQKMTR------GQLQDELEKGERDNAELQEFANAILQQIADH 1072
A + + A N+LQ+ QL ++L+ + + QE + +Q+ H
Sbjct: 551 --AKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAH 608
Query: 1073 CPDILEQVVN 1082
++V++
Sbjct: 609 LRAAQDRVLS 618
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 157 bits (396), Expect = 7e-38
Identities = 198/902 (21%), Positives = 389/902 (43%), Gaps = 130/902 (14%)
Query: 151 IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSP---------ELKKERALR 201
+ DLQ QL + E ES+L ++ + S E + ER L
Sbjct: 1287 LQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELL 1346
Query: 202 KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAE 261
+ +T E + E + L+++LR R +L ++ S A+
Sbjct: 1347 QAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERER---AQ 1403
Query: 262 LTEENFQRLHAEHERQAKELFLLRKTLEEMELRIET---QKQTLNARDESIKKLLEMLQS 318
+E + A+ + + L LL +TL E E +ET Q Q L + E K LE+L S
Sbjct: 1404 ALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELL-S 1462
Query: 319 KGLSAKATEED--HERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAK 376
L + E D E+ + L + + HL ++++E++ ++ RE++ R E ++ +
Sbjct: 1463 LDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI-RELEKDRETQR 1521
Query: 377 TKALQTVIEM--KDSKISSMERGLRDLEEEIQMLK------------------------- 409
++E+ KD I S ++DL++++ L+
Sbjct: 1522 NVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEG 1581
Query: 410 ---------SNGALSTEEREEEMK----QMEVYRSHSKFMKNKIGQVKQELSRKDTELLA 456
++ L EER +E++ Q+ SHS + ++ + QE+ + ++
Sbjct: 1582 QRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEE 1641
Query: 457 LQTKLETLTNQFSDSKQHIEVLKESLTAKE----QRAAILQTEVDALRLRLEEKETMLNK 512
LQ + E LT Q + + KE + E ++ IL+ +++ ++L L E+ L
Sbjct: 1642 LQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTT 1701
Query: 513 KTKQIQDMAEE-KG---TQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSS 568
+ + +Q+ AEE KG Q G + +K +L KE++V Q+ I LQE E+Q+
Sbjct: 1702 QRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQG 1761
Query: 569 LKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD 628
L +V T L+ E+ + ++ ++ +EQ + E+ Q ++D ++ L
Sbjct: 1762 LHRKVGE-------TSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQ 1814
Query: 629 LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQ 688
+++ LQ + + + +KE A +L + + LK L+ KE+ ++E +
Sbjct: 1815 RDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEE 1874
Query: 689 L--------------------KKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQA 728
L + E AL A + +++ Q E E +D +AQA
Sbjct: 1875 LAVEGRRVQALEEVLGDLRAESREQEKALLA-LQQQCAEQAQEHEVETRALQDSWLQAQA 1933
Query: 729 ---EVDRLLEILK-EVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQ--VEKKKSAQM 782
E D+ LE L+ E ++ ++ ++ A E + K A L+ KEQ +E+ + ++
Sbjct: 1934 VLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRS 1993
Query: 783 LE---------------EARRREDNLNDSSQQLQDSLRKKDDRIEELEEALR---ESVQI 824
LE +R+ E+ L ++QD + + +++L++AL E ++
Sbjct: 1994 LEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRH 2053
Query: 825 TAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNL 884
ERE +L + + R E+ + E+ ++E+ + + Q +LA+KE + L
Sbjct: 2054 QQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILEL 2113
Query: 885 RAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEV----AALKREKDRL 940
R ++++ E L + + + E+ L+L S + + Q E+ AAL++ + R
Sbjct: 2114 RETQQRNNLEALPHSHKT--SPMEEQS-----LKLDSLEPRLQRELERLQAALRQTEARE 2166
Query: 941 VQ 942
++
Sbjct: 2167 IE 2168
Score = 120 bits (301), Expect = 7e-27
Identities = 180/873 (20%), Positives = 355/873 (40%), Gaps = 122/873 (13%)
Query: 150 TIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKIT 209
T++ Q +L + ++ + LR+D++V++ K + ++T +L++ + K+ A +
Sbjct: 933 TLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQT----QLQEAQRELKEAARQ-- 986
Query: 210 IWKEQYRVVQEENQHMQMTIQALQDELRIQRDL----NQLFQQDSSSRTGEPCVAELTEE 265
++ +QEE+ + LQD++ +Q+ + +QL QD S R E V E E
Sbjct: 987 -HRDDLAALQEESSSL------LQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039
Query: 266 N--FQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSA 323
+ R+ E ER+ L L +L E E R+ ++ + R + + L + +Q
Sbjct: 1040 TQEYNRIQKELEREKASLTL---SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQ 1096
Query: 324 KATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTV 383
K E R+ E KEKE L +E E + L+
Sbjct: 1097 KELSAQMELLRQ---------------EVKEKEADFLAQEAQLLEELEASHITEQQLRAS 1141
Query: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVY-RSHSKFMKNKIGQ 442
+ +++K + ++ LR E +++ AL+ E++ Q + S ++ +G
Sbjct: 1142 LWAQEAKAAQLQLRLRSTESQLE------ALAAEQQPGNQAQAQAQLASLYSALQQALGS 1195
Query: 443 V---KQELS----------------RKDTELLALQTKLETLTNQFSDSKQHIEVLKESLT 483
V + ELS L L L+ + S H L + L
Sbjct: 1196 VCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH--KLHQDLW 1253
Query: 484 AKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKER 543
+Q +L+ +V L RL + E ++ ++QD+ + E + + E
Sbjct: 1254 KTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLES 1313
Query: 544 KVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKE----- 598
++ L + + +LQ +LR E Q + + LQA N + L+ A+ E
Sbjct: 1314 ELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASA 1373
Query: 599 -----------RTIERLKEQRDRDEREK----QEEIDNYKKDLKDLKEKVSLLQGDLSEK 643
R+ +LK + ERE+ QE+ + K L+E ++LL L+E+
Sbjct: 1374 AGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAER 1433
Query: 644 EASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASP 703
E + L+ L + + L+ L + L+++ +E + Q+++ + P
Sbjct: 1434 EEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLP 1493
Query: 704 EMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNK 763
+Q E+++T +++ + + + + +L+ E KD+ I QV+D K
Sbjct: 1494 MA---VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550
Query: 764 KVANLK----------HKEQVEKK--KSAQMLEEARR------------REDNLNDSSQQ 799
++ L+ HK + ++K K + E +R R L S Q
Sbjct: 1551 QLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQ 1610
Query: 800 LQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVK-- 857
+ D EL+E +E + E + Q+E + E++ +EL++ E+++
Sbjct: 1611 IHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVL 1670
Query: 858 -----QELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDA 912
++ + ++ L + SL E+ LT R ++ EE K + S +
Sbjct: 1671 EDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEG---KGPSKAQRGSLEHM 1727
Query: 913 NIALLELSSSKKKTQEEVAALKREKDRLVQQLK 945
+ L + + QE + L+ KD+L QQL+
Sbjct: 1728 KLILRDKEKEVECQQEHIHELQELKDQLEQQLQ 1760
Score = 114 bits (285), Expect = 5e-25
Identities = 194/939 (20%), Positives = 395/939 (42%), Gaps = 120/939 (12%)
Query: 121 DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS 180
D+ F + A T+ S+ R + DL+ QL +LL++ + E +
Sbjct: 372 DSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGK 431
Query: 181 SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR 240
+ ++ + E D ++ ++ ++Q+ + ++ ++ L+ E R
Sbjct: 432 ALRQRLQKL-TGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLR 490
Query: 241 DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ 300
+N Q S G+ EE + LH R+ L+EM + +E ++
Sbjct: 491 RVNVELQLQGDSAQGQK------EEQQEELHLAVRE--------RERLQEMLMGLEAKQS 536
Query: 301 TLNARDESIKKLL---EMLQSKGLSAKAT-EEDHERTRRLAEAEMHVHHLESLLEQKEKE 356
ES+ +L+ E L+S L + +E E T LA AE +S+ E E
Sbjct: 537 ------ESLSELITLREALESSHLEGELLRQEQTEVTAALARAE------QSIAELSSSE 584
Query: 357 NSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALST 416
N++ E R SA +AL K+ + + L LEEE Q + S +
Sbjct: 585 NTLKTEVADLRAAAVKLSALNEALAL------DKVG-LNQQLLQLEEENQSVCSRMEAAE 637
Query: 417 EERE-------EEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFS 469
+ R E K+ E + ++ ++ + ++ + +L +Q + E + + S
Sbjct: 638 QARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLS 697
Query: 470 DSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTK---QIQDMAEEKGT 526
+S+ E L Q A + + + L ++EKE ++ +K ++Q + ++
Sbjct: 698 ESRHQQEAATTQLEQLHQEA---KRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQD 754
Query: 527 QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 586
A ++ L ++ E + Q++ ++ E Q+ ++ + + +Q +
Sbjct: 755 LAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE 814
Query: 587 LTTLEEALAEKER--TIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKE 644
L T E + AE+ER +L + + +++ ++K++ L+EK EKE
Sbjct: 815 LDT-ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKW--------EKE 865
Query: 645 ASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPE 704
S H LA ALE + E +++E +LK+ + +EA +
Sbjct: 866 RSW-----HQQELAK--------------ALESLEREKMELEMRLKE-QQTEMEAIQAQR 905
Query: 705 MSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKK 764
+R Q E + + + E+ K + LLE L + + E D +++ L + +K Q K
Sbjct: 906 EEERTQ-AESALCQMQLETEKERVS---LLETLLQTQKELADASQQLERLRQDMKVQKLK 961
Query: 765 VANLKHKEQVEKKKSAQMLEEA-RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQ 823
Q + +++ + L+EA R+ D+L ++ L+ K D +++E+
Sbjct: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDL------ 1015
Query: 824 ITAEREMVLAQEESARTNAEKQVEELLMAME---KVKQELESMKAKLSSTQQSLAEKETH 880
+ ++AQ++S R E++V+E L + ++++ELE KA L+ SL EKE
Sbjct: 1016 ----KSQLVAQDDSQRL-VEQEVQEKLRETQEYNRIQKELEREKASLTL---SLMEKEQR 1067
Query: 881 LTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRL 940
L L+ +E+ ++Q+ A +K+ + A +EL +++ +E+ A ++ +L
Sbjct: 1068 LLVLQEADSIRQQELSALRQDMQEAQGEQKELS-AQMEL--LRQEVKEKEADFLAQEAQL 1124
Query: 941 VQQLKQQTQNRMKLMADNYEDD--------HFKSSHS--NQTNHKPSPDQIIQPLLELDQ 990
+++L+ +L A + + +S+ S + P Q +L
Sbjct: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLAS 1184
Query: 991 NRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQ 1029
S L+ +G ++C R L G + P+ + L+ DQ
Sbjct: 1185 LYSALQQALG---SVCESRPELSGGGDSAPSVWGLEPDQ 1220
Score = 110 bits (274), Expect = 9e-24
Identities = 159/832 (19%), Positives = 349/832 (41%), Gaps = 115/832 (13%)
Query: 137 STVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKK 196
STV Q RD + + Q++E+ R+ + L +D+E ++ +L L+K
Sbjct: 1618 STVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELM-------------LQK 1664
Query: 197 ER-ALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTG 255
ER + +D+ ++ Q ++++E+ + ++++++ EL QR QL Q+ + G
Sbjct: 1665 ERIQVLEDQRTR------QTKILEEDLEQIKLSLRERGRELTTQR---QLMQERAEEGKG 1715
Query: 256 EPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEM 315
QR EH ++ L + E +E Q++ ++ E +L +
Sbjct: 1716 --------PSKAQRGSLEH---------MKLILRDKEKEVECQQEHIHELQELKDQLEQQ 1758
Query: 316 LQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSA 375
LQ GL K E LL Q+E+E +L++++ E
Sbjct: 1759 LQ--GLHRKVGE------------------TSLLLSQREQEIVVLQQQLQEAREQG--EL 1796
Query: 376 KTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKF 435
K ++LQ+ ++ ++ ++ L L++E Q + E+ + +E K
Sbjct: 1797 KEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856
Query: 436 MKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAIL--- 492
++ K++ R + EL +++ L D + +++L A +Q+ A
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916
Query: 493 -QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKK 551
+ E AL+ + + +L ++ ++++ + E + + + + LQ+
Sbjct: 1917 HEVETRALQDSWLQAQAVLKERDQELEALRAESQSS-------RHQEEAARARAEALQEA 1969
Query: 552 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTT-------LEEALAEKERTIERL 604
+ L+ KE+ + E +SL+A T +L LEEAL +E I+
Sbjct: 1970 LGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQ 2029
Query: 605 KEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEK-EASLLDLKEHASSLASS--- 660
+ D ++ Q+ + ++L+ +E+ LL+ L+++ + +++ K++
Sbjct: 2030 DLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEI 2089
Query: 661 -GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRY 719
GL + ++ L++ L QK++E L++ ++ + AL S + +E + +
Sbjct: 2090 RGLHQS--VRELQLTLAQKEQEILELRETQQRNNLEAL------PHSHKTSPMEEQSLKL 2141
Query: 720 KDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKS 779
+ Q E++RL L++ E + + +K +L + V++L ++V
Sbjct: 2142 DSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL---QEVAMFLQ 2198
Query: 780 AQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESAR 839
A +LE + Q+LQD L LE+ S T+ E+ E+ +
Sbjct: 2199 ASVLER--------DSEQQRLQDELELTR---RALEKERLHSPGATSTAELGSRGEQGVQ 2247
Query: 840 ----TNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 895
+ E + M + +Q LE ++ ++ + + + H LR+ + E
Sbjct: 2248 LGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERER 2307
Query: 896 LEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQ 947
++K+EA+ AA A + +++ TQ++ K + V +L+++
Sbjct: 2308 RKLKREAMRAA----QAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKE 2355
Score = 103 bits (256), Expect = 1e-21
Identities = 163/846 (19%), Positives = 341/846 (40%), Gaps = 151/846 (17%)
Query: 259 VAELTEENFQRLHAEHERQAKELFLLRKT----------LEEMELRIETQKQTLNARDES 308
+AE ++++L E Q ++ L+RK +E+E R+E + R E+
Sbjct: 31 MAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWEN 90
Query: 309 IKK--LLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHR 366
+++ L E+L EE+ +R LAE L +E+ + N LRE++ +
Sbjct: 91 VEEPNLDELLVR-------LEEEQQRCESLAEVNTQ---LRLHMEKADVVNKALREDVEK 140
Query: 367 R---FENAPDSAKTKALQTVIEMK---------DSKISSMERGLRDLEEEIQMLKSNGAL 414
+ A D K Q +E + ++ S+ R + +KS
Sbjct: 141 LTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKS---- 196
Query: 415 STEEREEEMKQMEVYRSHSKF---MKNKIGQVKQELS-------RKDTELLALQTKLETL 464
+T+ E+K V S S ++ +G +E + R+ +LL L K + L
Sbjct: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQEL 256
Query: 465 TNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEK 524
+ + Q + LK ++ TE+ AL + +++ K K +++ E
Sbjct: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
Query: 525 GTQAGEI--HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT- 581
T E+ H+ + +E K++ LQ+ I+++ + + ++ ++ SL+ D++
Sbjct: 317 ETNHTELMEHEASLSRNAQEEKLS-LQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSI 375
Query: 582 -------NTDTALTTLEEALAEKERTIERLKEQRDRDEREK---QEEIDNYKKDLKDLKE 631
+ D ALT + L + + ++ L++Q + Q++ D ++++ K L++
Sbjct: 376 FSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQ 435
Query: 632 KVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKM------ 685
++ L G+ +DL+ SL+ + L LE ++E ++
Sbjct: 436 RLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVE 495
Query: 686 ------------ESQLKKAHEAA------------LEARASPEMSDRI--------QHLE 713
E Q ++ H A LEA+ S +S+ I HLE
Sbjct: 496 LQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLE 555
Query: 714 REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELER----------------- 756
E+ R E ++ A + R + + E+ + +N ++A+L
Sbjct: 556 GELLR--QEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKV 613
Query: 757 -------QVKDQNKKVAN-LKHKEQVEKKKSAQMLEEARRRE-------------DNLND 795
Q++++N+ V + ++ EQ + E +RRE +
Sbjct: 614 GLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEE 673
Query: 796 SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAM-- 853
+ +LQ LR + EE+++ L ES ++E Q E A++Q E L A+
Sbjct: 674 AGAELQADLRDIQEEKEEIQKKLSES---RHQQEAATTQLEQLHQEAKRQEEVLARAVQE 730
Query: 854 -EKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDA 912
E + +E +++ +L + ++ + L L + + + E +Q+ + +++
Sbjct: 731 KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL 790
Query: 913 NIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYED-----DHFKSS 967
+ + ++ +K+ Q EV LK E D Q +Q+ + +A ++ + K++
Sbjct: 791 EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAA 850
Query: 968 HSNQTN 973
H + N
Sbjct: 851 HEKEVN 856
Score = 59.7 bits (143), Expect = 1e-08
Identities = 113/621 (18%), Positives = 251/621 (40%), Gaps = 86/621 (13%)
Query: 491 ILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH-----------DLKDMLD 539
+L+ +V AL+ ++ E + +K K Q+ + + T ++ +L+ L+
Sbjct: 19 VLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLE 78
Query: 540 -----VKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEAL 594
+ +R NV + ++ L +L +++++ SL E L+ D L E +
Sbjct: 79 ATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDV 138
Query: 595 AEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD--------LKEKVSLLQGDLSEKEAS 646
+ R +++ R E + Q E + +K LK +E V+ + L K A+
Sbjct: 139 EKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSAT 198
Query: 647 LLDLKE-HASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEM 705
DL E A + SG L+ A ++ +M+ ++ + L + E+
Sbjct: 199 DRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDG--REPAQLLLLLAKTQEL 256
Query: 706 SDRIQHLEREITRYKDESSKAQAEV-DRLLEILKEVENEKNDKDKKIAELERQVKDQNKK 764
+E+ + K + +AE+ DR+ E+ + + ++Q +D K
Sbjct: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTEL-----------SALLTQSQKQNEDYEKM 305
Query: 765 VANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQI 824
+ L+ ++ + +++E E +L+ ++Q+ + SL++ I ++ +++
Sbjct: 306 IKALRETVEILETNHTELMEH----EASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361
Query: 825 TAEREMVLAQEESART-----NAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKET 879
+ E L + S + +A+K + + + + +Q ++ ++ +L+ Q+++
Sbjct: 362 GSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAV----- 416
Query: 880 HLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIA-LLELSSSKKKTQEEVAALKREKD 938
NL ++ EE + ++ L E+D ++L +E L++ ++
Sbjct: 417 ---NLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE 473
Query: 939 RLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLY 998
L QQL+ Q +L N E S Q ++ + +L
Sbjct: 474 ELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQK----------------EEQQEEL--- 514
Query: 999 IGHLTTLCHDRDPLILRGLTPPASYNLDD--------DQAAWENELQKMTRGQLQDELEK 1050
HL +R +L GL S +L + + + E EL + + ++ L +
Sbjct: 515 --HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALAR 572
Query: 1051 GERDNAELQEFANAILQQIAD 1071
E+ AEL N + ++AD
Sbjct: 573 AEQSIAELSSSENTLKTEVAD 593
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 154 bits (389), Expect = 4e-37
Identities = 216/1011 (21%), Positives = 445/1011 (44%), Gaps = 167/1011 (16%)
Query: 197 ERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGE 256
E + ++E +K+ + +Q + ++ T + +D+L +R +NQL + + S G
Sbjct: 1883 ELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLE-ERLMNQLAELNGS--IGN 1939
Query: 257 PC-----------VAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
C + E +N ++ +E E + ++L + KT E E+R E ++ A+
Sbjct: 1940 YCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQL-VKEKTKVESEIRKEYLEKIQGAQ 1998
Query: 306 DES-----IKKLLEMLQSKGLSAKATEEDHERTR-RLAEAEMHVHHLESLLEQKEKENSM 359
E K+L E+L+ K K ++D R + +++ E V LE + + +K+ +
Sbjct: 1999 KEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI 2058
Query: 360 LREEM-----HRR--------FENAPDSAKTKALQTVIEM----------KDSKISSMER 396
+E + HR+ F+ D +++A + + + K+S S M++
Sbjct: 2059 TKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ 2118
Query: 397 GLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLA 456
DLE ++ + +E++ ++++ R ++ IG+++ L++KD E+
Sbjct: 2119 KDEDLERRLEQAEEK---HLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQ 2175
Query: 457 LQTKLETLTNQ---FSDSKQHIE-----VLKESLTAKEQRAAILQTEVDALRLRLEEKET 508
LQ L++ Q F+ S ++ V+ E+ + + + +Q++ + +RL+ E+ +
Sbjct: 2176 LQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLK-EDNCS 2234
Query: 509 MLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK-ERKVNVLQKKIENLQEQLRDKEKQMS 567
+L + +Q+ EE + K + + K + +V + QK + LQ + ++ Q+
Sbjct: 2235 VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLE 2294
Query: 568 SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDE---REKQEEIDNYK- 623
+ S Q + ++ L +L++ L + ++E+ KEQ+ E R+++ +I N K
Sbjct: 2295 ETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKF 2354
Query: 624 ------KDLKDLKEKVSLLQGDLSEKE---ASLLDLKEHASSLASSGLKK--DSRLKTLE 672
DL+ +E S L +++ KE SLL KE A +A + L++ D +K LE
Sbjct: 2355 SYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELE 2414
Query: 673 IALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDR 732
L Q++EE + +E + KKA D+ L + K E+ + +A++D
Sbjct: 2415 NLLSQEEEENIVLEEENKKA-------------VDKTNQLMETLKTIKKENIQQKAQLDS 2461
Query: 733 LLEILKEVENEKN------------------DKDKKIAELERQVKDQNKKVANLK-HKEQ 773
++ + ++N+++ +KD+ I E + +++ L+ H +
Sbjct: 2462 FVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDD 2521
Query: 774 VEKKKSAQMLEEARRRED-----NLNDSSQ------------QLQDSLRKKDDRIEELEE 816
+ + + E + RED + DS Q +L++ K +++++E EE
Sbjct: 2522 LNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEE 2581
Query: 817 A---LRESVQITAEREMVLAQE-ESARTNAEKQVEELLMAME-----------KVK-QEL 860
A LR S E + L++E ES + + + ++ E KVK +E+
Sbjct: 2582 ANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEV 2641
Query: 861 ESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELS 920
+ A SS+Q+ +AE E L ++ E K + E+ + ++ L DA I +
Sbjct: 2642 HRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHL--HHDAGI----MR 2695
Query: 921 SSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQ 980
+ + +E VA L R+ + Q+L T+ L A SS N +H
Sbjct: 2696 NETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANE--- 2752
Query: 981 IIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILR----GLTPPASYNLDDDQAAWENEL 1036
ELD+ + K Y L L ++ +L L +++++ + + L
Sbjct: 2753 ------ELDELKRK---YDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHL 2803
Query: 1037 QKMTRGQLQDELE------KGERDNAELQEFANAI--LQQIADHCPDILEQ 1079
+K+ + L + + + E ++Q F+ A+ LQ DH + LE+
Sbjct: 2804 EKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEK 2854
Score = 143 bits (361), Expect = 8e-34
Identities = 210/1051 (19%), Positives = 436/1051 (41%), Gaps = 151/1051 (14%)
Query: 139 VPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWS--PELKK 196
V L+Q D Q +E+ E DLL+K+ E ++ KL +++ + K L++
Sbjct: 955 VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE 1014
Query: 197 ERALRKDEASKITIWKEQYRVVQEENQ-------------------HMQMTIQALQDELR 237
E A KDE+ K E R EE++ +++ TI + EL+
Sbjct: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
Query: 238 -IQRDL-------------------------NQLFQQDSSSRTGEPCVAELTEENFQRLH 271
I++DL NQ+ + + + +L N
Sbjct: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASD 1134
Query: 272 AEHERQAKELFLL-----------RKTLEEMELRIETQKQTLNARDESIKKLLEMLQS-K 319
+ KE ++ + LEE L +E +K+ L KKL E L S K
Sbjct: 1135 GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQ------KKLQEALTSRK 1188
Query: 320 GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKA 379
+ KA E++ L + + + L+ +++ KEN + +++ + +S K
Sbjct: 1189 AILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKL 1248
Query: 380 LQTVIEMKDSKISSMERGLRDLEEEIQ---MLKSNGALSTEEREEEMKQMEVYRSHSKFM 436
T + S +E L E+ +L+SN E+ ++ S
Sbjct: 1249 PSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTS----- 1303
Query: 437 KNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEV 496
+ Q+K +L + E + L+ K+ + T++ + + + L+E + + L+T
Sbjct: 1304 ---VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVS 1360
Query: 497 DALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQ 556
+ E + L QI + + Q ++ +L+ ++ KE V+ L ++ +
Sbjct: 1361 HEAEVHAESLQQKLESSQLQIAGLEHLRELQP-KLDELQKLISKKEEDVSYLSGQLSEKE 1419
Query: 557 EQLRDKEKQMSSLKERVKS----LQADTTNTDTALTTLEEALAEKERTIERLKEQ---RD 609
L + ++ ++ +K+ L+ D + L+ L E ++ E + E+ +
Sbjct: 1420 AALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQ 1479
Query: 610 RDEREKQEEIDNYKKDLKD---LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 666
+ +R+ Q + + K+ LK+ L+E++SL +G + SL D++ S +++ +KD+
Sbjct: 1480 QIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVE---SQVSAQNKEKDT 1536
Query: 667 RLKTLEIALEQKKEECLKME-------------SQLKKAHEAALEARASPEMSDRIQHLE 713
L L + E++ + +M+ LK A E E + ++ I+ L+
Sbjct: 1537 VLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDK--EKLVKEIESLK 1594
Query: 714 ----REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLK 769
E T ++++ + Q E + LL+ + V NE ++I + V+ + +++
Sbjct: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEA----ERIQHVVEAVRQEKQELYGKL 1650
Query: 770 HKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAERE 829
+ KK++ + L+EA E + + ++++ + K +I ELEE E +
Sbjct: 1651 RSTEANKKETEKQLQEA---EQEMEEMKEKMRKFAKSKQQKILELEE----------END 1697
Query: 830 MVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERR 889
+ A+ A A++ +E LL + +K+ELE +K + ++L++K +L +E+
Sbjct: 1698 RLRAEVHPAGDTAKECMETLLSSNASMKEELERVKME----YETLSKK---FQSLMSEKD 1750
Query: 890 KHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEE----VAALKREKDRLVQQLK 945
EEV ++K + + K AN+ E ++ EE + E+D L +
Sbjct: 1751 SLSEEVQDLKHQ--IEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTR 1808
Query: 946 QQ-TQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTT 1004
+++ + N SSH N+ DQ+ + + L++ + K K + T
Sbjct: 1809 PTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEF---SQT 1865
Query: 1005 LCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANA 1064
L ++++ L+ + T + ++ N L + + +L + E E +
Sbjct: 1866 LENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEER 1925
Query: 1065 ILQQIAD-------HCPDILE-QVVNALEES 1087
++ Q+A+ +C D+ + Q+ N L ES
Sbjct: 1926 LMNQLAELNGSIGNYCQDVTDAQIKNELLES 1956
Score = 132 bits (333), Expect = 1e-30
Identities = 222/1088 (20%), Positives = 455/1088 (41%), Gaps = 204/1088 (18%)
Query: 153 DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKT--FWSPELKKERALRKDEASKITI 210
+LQ LKE +E L+KD + K+S+ ++K F E +K+ + K+ ++
Sbjct: 2009 ELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE 2068
Query: 211 WKEQ-------YRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELT 263
+++ ++V+ ++ Q + L D L+++++L + S + E
Sbjct: 2069 HRKKAQAELASFKVLLDDTQ--SEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERR 2126
Query: 264 EENFQRLHAEHERQAKE-LFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK--- 319
E + H + ++ +E L LR+ +E I + TLN +D+ +++L E L S
Sbjct: 2127 LEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQ 2186
Query: 320 --GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKT 377
+ + +R R + EA+ ++ KE EE+ + +N K
Sbjct: 2187 LAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKE-------EEIRLKEDNC-SVLKD 2238
Query: 378 KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMK 437
+ Q I M++ KI+ + LE + Q+ +S + E + + K + + +K +
Sbjct: 2239 QLRQMSIHMEELKIN-----ISRLEHDKQIWESK---AQTEVQLQQKVCDTLQGENKELL 2290
Query: 438 NKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESL-----TAKEQRAAI- 491
+++ + + EL L+++L++L +Q +D +E KE ++Q A I
Sbjct: 2291 SQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQ 2350
Query: 492 --------LQTEVDALR---------LRLEEKE--TMLNKKTKQIQ-DMAEEKGTQAGEI 531
L+T++ A R + ++E++ ++L+ K + IQ +AE + EI
Sbjct: 2351 NSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEI 2410
Query: 532 HDLKDMLDVKER--------------KVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQ 577
+L+++L +E K N L + ++ ++++ ++ Q+ S + + SLQ
Sbjct: 2411 KELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQ 2470
Query: 578 ADTTNTDTALTTLEEA----LAEKERTIE-------RLKEQ----------RDRDEREKQ 616
D LEE + EK++ I+ +LKE+ + + +
Sbjct: 2471 NDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLD 2530
Query: 617 EEIDNYKKDL----------------------KDLKEKVSLLQGDLSEKEASLLDLKEHA 654
E+ Y++DL K+L+ K + L+ L E E + DL+
Sbjct: 2531 AELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSF 2590
Query: 655 SSLASSGLKKDSRLKTLEIALEQKKEECLKME---------SQLKKAHEAALEARASPEM 705
++L +++L++++ Q + ++ +QLK E A
Sbjct: 2591 NALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSS 2650
Query: 706 SD-RIQHLEREITRYKDESSKAQAEV-DRLLEILKEVE-------NEKNDKDKKIAELER 756
S RI LE E+ + E++K E+ D+L + LK + NE ++++AEL R
Sbjct: 2651 SQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELAR 2710
Query: 757 QVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDS----SQQLQDSLRKKDDRIE 812
+ + +K+ + E K ++ R +L +S +++L + RK D ++
Sbjct: 2711 DLVEMEQKLLMVTK----ENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLK 2766
Query: 813 ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 872
EL + L+E + ER+ +L++ + + E E L +EK+ Q+L S +L
Sbjct: 2767 ELAQ-LKEQGLLNRERDALLSETAFSMNSTE---ENSLSHLEKLNQQLLSKDEQLLHLSS 2822
Query: 873 SLAEKETHLTNLRA------ERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKT 926
L + + + R HL LE ++ SE+ + + S+S +
Sbjct: 2823 QLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRK------SEEGKQRSAAQPSTSPAEV 2876
Query: 927 Q---EEVAALKREKDRLVQQLK-----------------------QQTQNRMK---LMAD 957
Q + +++L+ ++DRL+++LK Q+ Q++ K +M +
Sbjct: 2877 QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQE 2936
Query: 958 NYEDDHFKSSH----------SNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCH 1007
++ H S + + + +Q + + + DQ S L+ I L +
Sbjct: 2937 ELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSS 2996
Query: 1008 DRDPLIL---RGLTPPASYNLDDDQ-AAWENELQKMTRGQLQDELEKGERDNAELQEFAN 1063
PL + R +P S + D Q +E EL R QL D L++ + +Q+ +
Sbjct: 2997 QTQPLKVQYQRQASPETSASPDGSQNLVYETEL---LRTQLNDSLKEIHQKELRIQQLNS 3053
Query: 1064 AILQQIAD 1071
Q + +
Sbjct: 3054 NFSQLLEE 3061
Score = 126 bits (317), Expect = 1e-28
Identities = 187/902 (20%), Positives = 388/902 (43%), Gaps = 116/902 (12%)
Query: 147 RDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEAS 206
+++ I L TQL+ +E+D K ++V+ ++ I + + +R L+ S
Sbjct: 1432 QEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALIS 1491
Query: 207 KITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEEN 266
+ KE + +QEE + TI+ L L +Q+ Q+ T +A L EE
Sbjct: 1492 RKEALKEN-KSLQEELSLARGTIERLTKSLADVE--SQVSAQNKEKDTVLGRLALLQEER 1548
Query: 267 FQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKAT 326
+L E +R E L + E ++L +E + +++ +K++ + SK +
Sbjct: 1549 -DKLITEMDRSLLENQSLSSSCESLKLALEGLTED---KEKLVKEIESLKSSKIAESTEW 1604
Query: 327 EEDHERTRR------------LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDS 374
+E H+ ++ EAE H +E++ ++K++ LR + E +
Sbjct: 1605 QEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKET--EK 1662
Query: 375 AKTKALQTVIEMKDSK---ISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRS 431
+A Q + EMK+ S ++ + +LEEE L++ + + +E ME S
Sbjct: 1663 QLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE---CMETLLS 1719
Query: 432 HSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIE--VLKES-LTAKEQ- 487
+ MK ++ +VK E + +L ++ ++L+ + D K IE V K++ L A E+
Sbjct: 1720 SNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKH 1779
Query: 488 --RAAILQTEVDALRLRLEEKETMLNK----------KTKQIQDMAEEKGTQAGEIHDLK 535
+ + + ++ EE++++ K + + EI++
Sbjct: 1780 DNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYL 1839
Query: 536 DMLD-VKERKVNVLQKKIENLQ-EQLRDKEK-----QMSSLKERVKSLQADTTNTDTALT 588
+D +KER + ++K +N + Q + EK Q+S+ +K LQ + T +
Sbjct: 1840 QQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQ 1899
Query: 589 TLEEALAEKERTIERLKEQRDRDER-------EKQEEIDNYKKDLKDLKEKVSLLQGDLS 641
++E L+ + E +E++D E E I NY +D+ D + K LL+ ++
Sbjct: 1900 QIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMK 1959
Query: 642 EKEASLLDLKEHASSLASSGLKKDSRL---------------------KTLEIALEQKKE 680
+ + +L+E L K +S + K L+ L++K++
Sbjct: 1960 NLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ 2019
Query: 681 ECLKMESQLKKAHE--AALEARASP------EMSDRIQHLEREITRYKDESSKAQAEVDR 732
E +++ + E +ALE E ++ + + + + KAQAE+
Sbjct: 2020 EVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS 2079
Query: 733 LLEILKEVENE---------------KNDKDKKIAELERQVKDQNKKVANLKHKEQVEKK 777
+L + ++E +++K+ ++++++ +D +++ + K EKK
Sbjct: 2080 FKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKK 2139
Query: 778 KSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESV-QITA-EREMVLAQE 835
+ L+ RR + +L ++ ++Q +L KKD +++L+E L +V Q+ A + M Q+
Sbjct: 2140 NMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Query: 836 ESART--NAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLR--AERRKH 891
+ R A+K + A++ ++E+ + S + L + H+ L+ R +H
Sbjct: 2200 DRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEH 2259
Query: 892 LEEVLEMK-------QEALLAAI--SEKDANIALLELSSSKKKTQEEVAALKREKDRLVQ 942
+++ E K Q+ + + K+ L E +Q E+A L+ E L
Sbjct: 2260 DKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKD 2319
Query: 943 QL 944
QL
Sbjct: 2320 QL 2321
Score = 114 bits (284), Expect = 7e-25
Identities = 221/1082 (20%), Positives = 449/1082 (41%), Gaps = 170/1082 (15%)
Query: 148 DNTIMDLQTQLKEVLREND-LLRKDVEVKESKLSSS-MNSIKTFWSPELKKERALRK-DE 204
+ I LQ ++ E+ E LL +E++E K + ++S T + + A R+ E
Sbjct: 467 EENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSE 526
Query: 205 ASKITIWKEQYRVVQEENQH-MQMTIQALQDELRI--------QRDLNQLFQQDSSSRTG 255
S + I ++ +E Q ++ T EL + Q ++ L Q R
Sbjct: 527 ISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAE 586
Query: 256 EPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIE-------TQKQTLNARDES 308
E L ++ +++ E K L T ++ L +K+ + +S
Sbjct: 587 EADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQS 646
Query: 309 IKKLLEMLQSKGLSAKATEEDHERT-------------------RRLAEAEMHVHHLESL 349
L G+ K+T++D +++ ++ E E++ H + +
Sbjct: 647 RTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEI 706
Query: 350 ----LEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMER--GLRDLEE 403
L++K KE S L + + +NA +++ A + E +D +S ++ + +L
Sbjct: 707 YEKNLDEKAKEISNLNQLIEEFKKNADNNSS--AFTALSEERDQLLSQVKELSMVTELRA 764
Query: 404 EIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLET 463
+++ L+ N L+ ER+ + E +H + +I + E KD ++ LQ +L+
Sbjct: 765 QVKQLEMN--LAEAERQRRL-DYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDD 821
Query: 464 LTNQFSDSKQHIEVLKESLTAKE-------QRAAILQTEVDALRLRLEEKE--------T 508
+ QFS+ I L+ L KE +R + ++V+ L L +KE
Sbjct: 822 VQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQL 881
Query: 509 MLNKK--TKQIQDMAEEKGTQAGEI--HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEK 564
+L KK + +Q EEK Q EI + M+ + E K + L +I+ L+EQL +
Sbjct: 882 LLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS-LGVEIKTLKEQLNLLSR 940
Query: 565 QMSSLKERVKSLQADTT----NTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEID 620
+ KE+V+ ++ N D + + E + + LK++ ++ +R+ Q +
Sbjct: 941 AEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALI 1000
Query: 621 NYKKDLK---DLKEKVSLLQGDLSEKEASLL-----DLKEHASSLASSGLKKDSRLKTLE 672
N K+ L+ L+E+++ L+ D S+KE L +++E + S S+ + +E
Sbjct: 1001 NRKELLQRVSRLEEELANLK-DESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIE 1059
Query: 673 IALEQKKEECLKMESQLKKAHEAALEARAS-----PEMSDRIQHLEREITRYKDESSKAQ 727
I L+Q E ++K E L A +M+ +Q +I + E S+ Q
Sbjct: 1060 IYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQ 1119
Query: 728 AEVDRLL------------EILKEV-----------ENEKNDKDKKIAELERQVKDQNKK 764
A + +L+ ++KE E+ K + ++KI LE++ + KK
Sbjct: 1120 AIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKK 1179
Query: 765 VAN-LKHKEQVEKK---KSAQMLEEARRREDNLNDSSQQLQDSLRKKD---DRIEELEEA 817
+ L ++ + KK K + EE ++++D+ N +Q + ++ + D++ +L+
Sbjct: 1180 LQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQ 1239
Query: 818 LRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEK--VKQELES------------- 862
+RES+ + ++ ++ + ++ E L A E+ + LES
Sbjct: 1240 VRESI----DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDA 1295
Query: 863 -----------MKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKD 911
+KA+L + E E +++ +E K EEV +++++ I+++
Sbjct: 1296 SALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQ-----INKQG 1350
Query: 912 ANIALLELSSSKKKTQEEVAALKREKDRL-------VQQLKQQTQNRMKLMADNYEDDHF 964
I L+ S + + E K E +L +++L+ + KL++ ED
Sbjct: 1351 LEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEED--- 1407
Query: 965 KSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYN 1024
S S Q + K + IQ E+ + +K L + D I +
Sbjct: 1408 VSYLSGQLSEKEAALTKIQ--TEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMK 1465
Query: 1025 LDDDQAAWENELQKMTRGQLQDEL---EKGERDNAELQE---FANAILQQIADHCPDILE 1078
++ E+ ++ + +LQ L ++ ++N LQE A ++++ D+
Sbjct: 1466 QKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVES 1525
Query: 1079 QV 1080
QV
Sbjct: 1526 QV 1527
Score = 112 bits (280), Expect = 2e-24
Identities = 169/869 (19%), Positives = 347/869 (39%), Gaps = 143/869 (16%)
Query: 143 LRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRK 202
LRQ D I +L+ L + EN +L ++ + K + M ++KT ++++ L
Sbjct: 2402 LRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDS 2461
Query: 203 DEASKITIWKEQYRVV----QEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPC 258
S ++ ++ R+V Q E +H+ + ++ Q + N+L ++ R+
Sbjct: 2462 FVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRS---- 2517
Query: 259 VAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLE--ML 316
+ L++E+ + EL R+ L Q + +D K+LLE +
Sbjct: 2518 -------HMDDLNSENAKLDAELIQYREDL----------NQVITIKDSQQKQLLEVQLQ 2560
Query: 317 QSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAK 376
Q+K L K + LE+K KE+ E++ R F
Sbjct: 2561 QNKELENKYAK----------------------LEEKLKESEEANEDLRRSF-------- 2590
Query: 377 TKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKF- 435
ALQ + +I S++ + L ++ L+ G L + ++K+ EV+R + F
Sbjct: 2591 -NALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFS 2649
Query: 436 -MKNKIGQVKQELSRKDTELLALQTKLE-TLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 493
+ +I ++++EL E ++E L + +++ E+R A L
Sbjct: 2650 SSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELA 2709
Query: 494 TEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKD----MLDVKERKVNVLQ 549
++ + +E+K M+ K+ K + + G + + +D LD +RK +
Sbjct: 2710 RDL----VEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASL 2765
Query: 550 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD 609
K++ L+EQ ++ + L E S+ + N+ + L L + L K+ + L Q +
Sbjct: 2766 KELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLE 2825
Query: 610 RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLK 669
+ ++ ++ K + L+ + L +L EK + K+ +++ S+ + LK
Sbjct: 2826 ----DSYNQVQSFSKAMASLQNERDHLWNEL-EKFRKSEEGKQRSAAQPSTSPAEVQSLK 2880
Query: 670 TLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAE 729
+L+ ++ LK +LK + L+ + +EIT
Sbjct: 2881 KAMSSLQNDRDRLLK---ELKNLQQQYLQ-------------INQEITE----------- 2913
Query: 730 VDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR 789
L LK E DK K ++ +++ +N + H Q+ +KS+ + E R +
Sbjct: 2914 ----LHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELH--QLRMEKSSWEIHERRMK 2967
Query: 790 EDNL---NDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQV 846
E L +D QQL ++ L LR S T ++ ++ S T+A
Sbjct: 2968 EQYLMAISDKDQQL--------SHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDG 3019
Query: 847 EELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAA 906
+ L+ E E ++ +L+ + + + +KE + L + + LEE
Sbjct: 3020 SQNLV------YETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEE------------ 3061
Query: 907 ISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKS 966
+ +I L + S S ++ Q+ L L +Q+++ + N +
Sbjct: 3062 --KNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPL-----NIDVAPGAP 3114
Query: 967 SHSNQTNHKPSPDQIIQPLLELDQNRSKL 995
N + K P+++ +P + + +L
Sbjct: 3115 QEKNGVHRKSDPEELREPQQSFSEAQQQL 3143
Score = 112 bits (279), Expect = 2e-24
Identities = 210/1008 (20%), Positives = 429/1008 (42%), Gaps = 135/1008 (13%)
Query: 142 SLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALR 201
+L + RD L +Q+KE+ +L R V+ E L+ + + + + + L
Sbjct: 741 ALSEERDQ----LLSQVKELSMVTEL-RAQVKQLEMNLAEAERQRRLDYESQTAHDNLLT 795
Query: 202 KDEAS-KITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVA 260
+ S I + ++ +N+ + +Q + I+ +QL ++S G V
Sbjct: 796 EQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVR 855
Query: 261 ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESI--------KKL 312
++ + + L ++ E+ + + L E + +ET +QT+ +D+ + +K+
Sbjct: 856 HISSK-VEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKM 914
Query: 313 LEMLQSK---GLSAKATEEDHERTRRLAEAEMHV----HHLESLLEQKEKENS----MLR 361
+++ + K G+ K +E R EA+ + + S L+Q E S + +
Sbjct: 915 VQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISK 974
Query: 362 EEMHRRFE---NAPDSAKTKALQTVIEMKD--SKISSMERGLRDLEEEIQMLKSNGALST 416
EE+ F+ + K K +I K+ ++S +E L +L++E K LS
Sbjct: 975 EELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDES---KKEIPLSE 1031
Query: 417 EEREEEMKQMEVYRSHSKFMKNKIGQV----KQELSRKDTELLALQTKLETLTNQFSDSK 472
ER E + E K + +K ++ KQ +S K+ EL ++ LE +
Sbjct: 1032 TERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091
Query: 473 QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQA---- 528
++ + ++L K + +LQ E+ + +++ T N +A K T
Sbjct: 1092 ALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITS-NTDASDGDSVALVKETVVISPP 1150
Query: 529 --GEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 586
G K L E K+ L+K+ E LQ++L++ ++S K +K Q +
Sbjct: 1151 CTGSSEHWKPEL---EEKILALEKEKEQLQKKLQEA---LTSRKAILKKAQEKERH---- 1200
Query: 587 LTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS--LLQGDLSEKE 644
L E L +++ RL+EQ D +E + D ++ ++E + L D E
Sbjct: 1201 ---LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESC 1257
Query: 645 ASLLDLKE---------HASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKK--AH 693
+S L+E H + S L D + + + Q ++++QLK+ A
Sbjct: 1258 SSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAE 1317
Query: 694 EAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAE 753
+ LE + S S+ + E E+ + +++ +K E++ L + E E +K+
Sbjct: 1318 KVELELKVSSTTSELTKKSE-EVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLES 1376
Query: 754 LERQVK------------DQNKKVANLKHKE------QVEKKKSA--QMLEEARRREDNL 793
+ Q+ D+ +K+ + K ++ Q+ +K++A ++ E +ED +
Sbjct: 1377 SQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLI 1436
Query: 794 NDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAM 853
QL+ ++ D+RI++L+ L E Q E + +E A+ +++++ L++
Sbjct: 1437 KALHTQLEMQAKEHDERIKQLQVELCEMKQKPEE----IGEESRAKQQIQRKLQAALISR 1492
Query: 854 EKVKQELESMKAKLSSTQ-------QSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAA 906
++ +E +S++ +LS + +SLA+ E+ ++ E+ L L + QE
Sbjct: 1493 KEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGR-LALLQEERDKL 1551
Query: 907 ISEKDANIALLE---LSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDH 963
I+E D + LLE LSSS + + + L +K++LV++++ +++
Sbjct: 1552 ITEMDRS--LLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIA---------- 1599
Query: 964 FKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASY 1023
S Q HK + + LL+ +N S I H+ ++ L G
Sbjct: 1600 --ESTEWQEKHKELQKEY-EILLQSYENVSNEAERIQHVVEAVR-QEKQELYGKLRSTEA 1655
Query: 1024 NLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIAD 1071
N +K T QLQ+ ++ E ++++FA + Q+I +
Sbjct: 1656 N------------KKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILE 1691
Score = 104 bits (259), Expect = 5e-22
Identities = 189/894 (21%), Positives = 354/894 (39%), Gaps = 182/894 (20%)
Query: 232 LQDELRIQRDL--NQLFQQDSSSRTG--EPCVAELTEENFQRLHAEHERQAKELFLLRKT 287
L EL + D+ N Q+D R E V EL + Q+ + + Q K+ L++
Sbjct: 30 LDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQK---DVQLQQKDE-ALQEE 85
Query: 288 LEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERT-----RRLAEAEMH 342
+ + +I+ K A+ S+ K +E ++++G + TE E + E EM
Sbjct: 86 RKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEME 145
Query: 343 VHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLE 402
+ ++ L++KE+ S L+ ++ + P + T+ + V M ++ E + L+
Sbjct: 146 IEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFV--MMKQQLQEKEEFISTLQ 203
Query: 403 EEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLE 462
++ ++ A RE++ + R H + + Q E + +L LQ KLE
Sbjct: 204 AQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQ-KLRVLQRKLE 262
Query: 463 TLTNQFSDSKQHIEVLKESLTAKEQRAAIL------------------QTEVDALRLRLE 504
Q +++L++ LTA EQR IL +TE + ++ LE
Sbjct: 263 EHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLE 322
Query: 505 EKETMLNKKTKQIQDMAE------EKGTQAGEI--------------------------- 531
+ E + ++ ++ E E+ QAG+
Sbjct: 323 KMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHIL 382
Query: 532 ------HDLKDMLD-VKERKVNVLQKK----------IENLQEQLRDKEKQMSSLKERVK 574
+L+ D +K++ +LQ K I+ L++QL+ K K++S R+
Sbjct: 383 SLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRL- 441
Query: 575 SLQADTTNTDTALTTL--EEALAEKERTIERLKEQRDRDEREK------QEEIDNYKKDL 626
LQ T + T+ + E A E I L+++ E EK E++ K +
Sbjct: 442 PLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAEN 501
Query: 627 KDLKEKVSLL-------QGDLSEKEASLLDLKEHASS---------LASSGLKKDSRLKT 670
+ L +++LL + D E S++D+ SS L ++ +K L
Sbjct: 502 EKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSV 561
Query: 671 LEIALEQKKEEC--LKMESQLKKAHEAALEARASPEMSDR-------------IQHLERE 715
L + +++ +EE LK++ Q K+A EA E EM ++ ++
Sbjct: 562 LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQD 621
Query: 716 ITRYKDESS------KAQAEVDR---------LLEILKEVENEKNDKDKKIA-------- 752
+E S K QA + L + E+++ K D DK ++
Sbjct: 622 FPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQC 681
Query: 753 ---ELER------QVKDQNKKVANLKHKEQVEKKKSAQML----EEARRREDNLNDSSQQ 799
ELER +++ K + K EK K L EE ++ DN + +
Sbjct: 682 HQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTA 741
Query: 800 LQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESAR-----------TNAEKQVEE 848
L + + +++EL Q+ + EM LA+ E R +Q+
Sbjct: 742 LSEERDQLLSQVKELSMVTELRAQV-KQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHS 800
Query: 849 LLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLE---------MK 899
L + + ++E ++ +L Q +E+ T + +L+++ + EVLE K
Sbjct: 801 LSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSK 860
Query: 900 QEALLAAISEKDANIALL-ELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRM 952
E L A+S+K+ I + +L KK+ E + EKD+ V ++ +M
Sbjct: 861 VEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKM 914
Score = 92.4 bits (228), Expect = 2e-18
Identities = 137/695 (19%), Positives = 279/695 (40%), Gaps = 119/695 (17%)
Query: 479 KESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDML 538
K+ +E++AA ++ L+L + K T LNK I++M + GT ++ L
Sbjct: 78 KDEALQEERKAA--DNKIKKLKLHAKAKLTSLNK---YIEEMKAQGGTVLPTEPQSEEQL 132
Query: 539 DVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQAD----TTNTDTALTTLEEAL 594
++ + +IE ++ +L++KE+ +S+L+ ++ QA+ ++ +++ L
Sbjct: 133 SKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQL 192
Query: 595 AEKERTIERLKEQRDRDEREKQEEIDNYKKDLK-----------------------DLKE 631
EKE I L+ Q + + E+ + +KD + ++++
Sbjct: 193 QEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQ 252
Query: 632 KVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE--CLKMESQL 689
K+ +LQ L E E SL+ + L + R + L L+Q + E L+ +
Sbjct: 253 KLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET 312
Query: 690 KKAHEAALEARASPEMSDR------IQHLEREITRYKDESSKAQAEVDRLLEILKEVEN- 742
++ L + E+++R +Q + +++ +AQAE++ L++
Sbjct: 313 EREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKA 372
Query: 743 EKNDKDKKIAELER----------QVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDN 792
E +K I L++ +KDQN K+ K+++ V+ ++ Q L ED
Sbjct: 373 EMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQL------EDQ 426
Query: 793 LNDSSQQLQDSLRK--------------KDDRIEELEEALRESVQITAEREMVLAQEESA 838
L S+++ L + D E + E++ +R + L E+ A
Sbjct: 427 LQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGA 486
Query: 839 RTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEM 898
+ ++EEL EK+ ++ ++A+ + + E + ++ +R E E
Sbjct: 487 LLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAE---ES 543
Query: 899 KQEALLAAISEKDANIALLELSSSKKKTQEEVAALK--------REKDRLVQQLKQQTQN 950
Q+ L S+K +++L L K+ QEE+A LK E D V K+ Q
Sbjct: 544 GQDVLENTFSQKHKELSVLLL--EMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQM 601
Query: 951 --------RMKLMADN-----------------YEDDHFKSSHSNQTNHKPSPDQIIQPL 985
+MK+ ++ E + + H ++T+ + S + L
Sbjct: 602 EGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVEL 661
Query: 986 LELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTR---- 1041
Q+ K + + CH + L+ N Q +E L + +
Sbjct: 662 KSTKQDGDKSLSAVPDIGQ-CHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISN 720
Query: 1042 -GQLQDELEKGERDNAE----LQEFANAILQQIAD 1071
QL +E +K +N+ L E + +L Q+ +
Sbjct: 721 LNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKE 755
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 153 bits (387), Expect = 7e-37
Identities = 210/1018 (20%), Positives = 442/1018 (43%), Gaps = 149/1018 (14%)
Query: 151 IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITI 210
I++L++ L++ L+EN KD+ V + N T + K E K + +
Sbjct: 569 ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQD--AL 626
Query: 211 WKEQYRVVQEENQ--HMQMTIQALQDELRIQRDLNQLFQ---QDSSSRTGEPCVAELTE- 264
W E+ +V++++ Q ++ + Q++ + +D +FQ ++ + +T E + TE
Sbjct: 627 WTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTEL 686
Query: 265 -----ENFQRLHAEHERQAKELFLLR----KTLEEMELRIETQKQTLNARDESIKKLLEM 315
E + L A H+ + +EL +L+ K +E+E +++ QK + +SI K E+
Sbjct: 687 ESLSSELSEVLKARHKLE-EELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEV 745
Query: 316 ---LQSKGLSAKATEED---HERTRRLAEAEMHVHHLESLLEQKEKE--NSMLREEMHRR 367
K L + + + ER + L E + HV +LE+ +++ E E + + ++ +
Sbjct: 746 SIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQS 805
Query: 368 FENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQME 427
+++A +TKA + +++ +++ L DLE E +L A ++++ +++
Sbjct: 806 YQSATHE-QTKAY-------EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELD 857
Query: 428 VYRSHSKFMKNKIGQVKQELSRKDTELLAL-QTKLETLTNQFSDSKQ------------- 473
++ + + ++ + E+ +K L + ++KLE + +KQ
Sbjct: 858 AHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMR 917
Query: 474 -----HIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQA 528
IE+L + L+AKE IL E + E+K + +K K++Q+ ++K
Sbjct: 918 EGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKK---- 973
Query: 529 GEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALT 588
+LD + + L+K++EN +L KEKQ ++ + ++ QA++ A++
Sbjct: 974 --------LLDQEAK----LKKELENTALELSQKEKQFNA--KMLEMAQANSAGISDAVS 1019
Query: 589 TLE-------EALAEKERT---------IERLKEQRDRDEREKQEEIDNYKKDLKDLKEK 632
LE E+L E R ++L +Q + + + ++ ++++ +LK+K
Sbjct: 1020 RLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQK 1079
Query: 633 VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKE--ECLKMESQLK 690
+ L + E + LKE G+K+D+ L L+ L+QK L +
Sbjct: 1080 ILLFGCEKEEMNKEITWLKE-------EGVKQDTTLNELQEQLKQKSAHVNSLAQDETKL 1132
Query: 691 KAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENE----KND 746
KAH LE + + + L+ ++ K + + + +V L LK + E K+
Sbjct: 1133 KAHLEKLEVDLNKSLKEN-TFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSS 1191
Query: 747 KDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDS---------- 796
+K LE + + K L + + KK+ +LE N++ S
Sbjct: 1192 HEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRIS 1251
Query: 797 -----SQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLM 851
+ +++++L K + ELE LR+ + + Q E Q++ +
Sbjct: 1252 HCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKA 1311
Query: 852 AMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKD 911
+E + E E+++ + + QQ+ +EKE+ +T L+ E +++ V MK+E + EK
Sbjct: 1312 DIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEE-----LKEKK 1366
Query: 912 ANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQ 971
I+ L + Q + + EK+ + L++Q + D +D FK ++
Sbjct: 1367 VEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSK 1426
Query: 972 TNHKPSPDQIIQPLLELDQNRSKL--------KLYIGHLTTLCHDRDPLILRGLTPPASY 1023
+ I L ++D +K + H T+ ++ I L +Y
Sbjct: 1427 --------EKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTV---KELQIQLELKSKEAY 1475
Query: 1024 NLDDDQAAWENELQKMT------RGQLQDELEKGERDNAELQ---EFANAILQQIADH 1072
D+ + EL + +G+++D+ K E+ + L+ + A + ++ DH
Sbjct: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDH 1533
Score = 139 bits (349), Expect = 2e-32
Identities = 209/926 (22%), Positives = 390/926 (42%), Gaps = 120/926 (12%)
Query: 155 QTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKI-TIWKE 213
+T K++L + L+K++E +LS + A D S++ T KE
Sbjct: 968 ETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027
Query: 214 QYRVVQEENQHMQMTIQALQDELRI-QRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
Q + E ++ + L D + I ++ LNQ ++ + E+ E Q
Sbjct: 1028 QIESLTEVHR------RELNDVISIWEKKLNQQAEE----------LQEIHEIQLQEKEQ 1071
Query: 273 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
E +++ L EEM I K+ +D ++ +L E L+ K + +D +
Sbjct: 1072 EVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETK 1131
Query: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
+ H+ LE L + KEN+ L+E++ L+ + E K+S
Sbjct: 1132 LKA------HLEKLEVDLNKSLKENTFLQEQLVE-------------LKMLAEEDKRKVS 1172
Query: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT 452
+ L+ +EE Q LKS+ S + E+ K +E + + ++ ++ K T
Sbjct: 1173 ELTSKLKTTDEEFQSLKSSHEKSNKSLED--KSLEFKKLSEELA------IQLDICCKKT 1224
Query: 453 ELLALQTKLETLTNQFSDSKQHIEVLKES----LTAKEQRAAILQT----EVDALRLRLE 504
E L L+ K L N S SK + + + S T K + A +++T E++A +L
Sbjct: 1225 EAL-LEAKTNELIN-ISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLT 1282
Query: 505 EKETMLNKKTKQIQDMAEEKGTQAGEIH-DLKDMLDVKERKVNVLQKKIENLQEQLRDKE 563
E++ LN +Q EEK Q + D++ ++ KE LQK+ N Q+ +KE
Sbjct: 1283 EEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKE----ALQKEGGNQQQAASEKE 1338
Query: 564 KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYK 623
++ LK+ + + A+T ++E L EK+ I L +Q + Q I
Sbjct: 1339 SCITQLKKEL-------SENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS--- 1388
Query: 624 KDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECL 683
L + + +S L+ E++ LLD + S K D+ K ALEQ +
Sbjct: 1389 --LSEKEAAISSLRKQYDEEKCELLDQVQDLS------FKVDTLSKEKISALEQVDDWSN 1440
Query: 684 KMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENE 743
K KKA + Q+ +E+ + SK E D + +LKE ++
Sbjct: 1441 KFSEWKKKAQSRFTQH----------QNTVKELQIQLELKSKEAYEKDEQINLLKEELDQ 1490
Query: 744 KNDK-DKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQD 802
+N + D E+E KK +NL+ + + + + ++ + ++ + ++ L++
Sbjct: 1491 QNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKN 1550
Query: 803 SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELES 862
++KD +EL + L+ ++ E++ + + E E QV + +E K+ELE
Sbjct: 1551 YNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEH 1610
Query: 863 MKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMK----QEALLAAISEKDANIA--- 915
+ + S ++ L E L + A + L+ E K ++ LL+ + EK+
Sbjct: 1611 VNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGT 1670
Query: 916 ---LLELSSSKKKTQEEVAALKREKDRLVQQLKQQT---QNRMKLMADNYEDDHFKSSHS 969
L EL++ ++ + EV L+ EK + V+ + +T K +A E + S
Sbjct: 1671 ESHLSELNTKLQEREREVHILE-EKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGC 1729
Query: 970 NQTNHKPSPDQIIQPLLELDQ-----NRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYN 1024
Q ++ + + L E ++ + K + H C ++ LI
Sbjct: 1730 VQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLI----------K 1779
Query: 1025 LDDDQAAWENELQKMTRGQLQDELEK 1050
L+ +A ++E Q M G LQ+ELE+
Sbjct: 1780 LEHAEAK-QHEDQSMI-GHLQEELEE 1803
Score = 135 bits (340), Expect = 2e-31
Identities = 169/835 (20%), Positives = 355/835 (42%), Gaps = 87/835 (10%)
Query: 193 ELKKERAL---RKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR-DLNQLFQQ 248
ELK++ L K+E +K W ++EE T+ LQ++L+ + +N L Q
Sbjct: 1075 ELKQKILLFGCEKEEMNKEITW------LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQD 1128
Query: 249 DSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDES 308
++ + + ++L + + KE L++ L E+++ E K+ ++
Sbjct: 1129 ETKLKA-----------HLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
Query: 309 IKKLLEMLQS---------KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKE--- 356
+K E QS K L K+ E + ++ E+LLE K E
Sbjct: 1178 LKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELIN 1237
Query: 357 ------NSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKS 410
N++L H + +T ++ + +K +S +E LR L EE L
Sbjct: 1238 ISSSKTNAILSRISHCQH-------RTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNI 1290
Query: 411 NGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSD 470
+ +T + EE+ Q++ ++ + + + +++E + ++ + L + S+
Sbjct: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSE 1350
Query: 471 SKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE------EKETMLNKKTKQIQDMAEEK 524
+ + ++KE L K+ + L ++ L ++L+ EKE ++ KQ EEK
Sbjct: 1351 NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYD---EEK 1407
Query: 525 GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 584
++ DL KV+ L K+ + EQ+ D + S K++ +S NT
Sbjct: 1408 CELLDQVQDLSF-------KVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTV 1460
Query: 585 TALTTLEEALA----EKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDL 640
L E + EK+ I LKE+ D+ + + D +++K S L+ +L
Sbjct: 1461 KELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1520
Query: 641 SEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEAR 700
+ A +++L++H + ++ +S + L+ +QK E ++ +L+ E
Sbjct: 1521 KSQTARIMELEDH---ITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELG---- 1573
Query: 701 ASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKD 760
E +R++ E +I +++ +AE++ + L+ V K++++ LE +++
Sbjct: 1574 --EEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLES 1631
Query: 761 QNK-KVANLKHKEQ-----VEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 814
++ K+A LK K + ++K+ +QM E+ + + +L L++++ + L
Sbjct: 1632 ESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHIL 1691
Query: 815 EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 874
EE L+ +E +V ++ E++ + ++K +E K+S Q++L
Sbjct: 1692 EEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEE------KISVLQRNL 1745
Query: 875 AEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALK 934
EKE L + E+ + + EM+ + I + A E S QEE+
Sbjct: 1746 TEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKN 1805
Query: 935 REKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELD 989
++ +V Q ++ + + A ++ F + + + Q + ELD
Sbjct: 1806 KKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELD 1860
Score = 134 bits (336), Expect = 6e-31
Identities = 178/890 (20%), Positives = 400/890 (44%), Gaps = 118/890 (13%)
Query: 150 TIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPE---LKKERALRKDEAS 206
T+ +L+ QL+++ E + L + +L N IK+ + + ++ AL+K+ +
Sbjct: 1270 TVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGN 1329
Query: 207 KITIWKEQYRVVQEENQHMQMTIQA---LQDELRIQR-DLNQLFQQDSSSRTGEPCVAEL 262
+ E+ + + + + I A +++EL+ ++ +++ L +Q L
Sbjct: 1330 QQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQ-------------L 1376
Query: 263 TEENFQRLHAEHERQAKELFL--LRKTLEEMELRIETQKQTLNARDESI--KKLLEMLQS 318
T+ N Q L KE + LRK +E + + Q Q L+ + +++ +K+ + Q
Sbjct: 1377 TDLNVQ-LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQV 1435
Query: 319 KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKEN-------SMLREEM---HRRF 368
S K +E + R + + V L+ LE K KE ++L+EE+ ++RF
Sbjct: 1436 DDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRF 1495
Query: 369 -----ENAPDSAKTKA----LQTVIEMKDSKISSMERGLRDLEEEIQ----MLKSNGALS 415
E D +K + L+T ++ + ++I +E + EI+ +LK+
Sbjct: 1496 DCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQK 1555
Query: 416 TEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHI 475
E +E +++++ ++ + N++ + ++++ + ++ +++ +LET + +
Sbjct: 1556 DIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSV 1615
Query: 476 EVLKESLTAKEQRAAILQTEVDA----LRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 531
+ +E L A E R L++E A L+ + E+K + K+ + EE+ + E
Sbjct: 1616 KSKEEELKALEDR---LESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTES 1672
Query: 532 H--DLKDMLDVKERKVNVLQKK---IENLQEQLRDKEKQMSSLKERVKSLQADTTNT--- 583
H +L L +ER+V++L++K +E+ Q + + ++ + +AD+
Sbjct: 1673 HLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQK 1732
Query: 584 --DTALTTLEEALAEKERTIERLKEQRDRD------------------------EREKQE 617
+ ++ L+ L EKE+ ++R+ ++++ + E Q
Sbjct: 1733 TYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQS 1792
Query: 618 EIDNYKKDLKDLKEKVSLLQGDLSEKEASL--LDLKEHASSLASSGLKKDSRLKTLEIAL 675
I + +++L++ +K SL+ EKE + K++ ++ K + L
Sbjct: 1793 MIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQIL 1852
Query: 676 EQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKD----ESSKAQAEVD 731
EQK +E + K+ H +E S +++Q L++ R K E + +
Sbjct: 1853 EQKIKELDSCLVRQKEVHRVEMEELTSKY--EKLQALQQMDGRNKPTELLEENTEEKSKS 1910
Query: 732 RLLE--ILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR 789
L++ +L +E + ND + K+A ER+ + K++ L+ ++ +K+ Q LE ++
Sbjct: 1911 HLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKE 1970
Query: 790 EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEEL 849
D Q+ ++ ++++ + +E + + Q+ E LAQ+E E ++E
Sbjct: 1971 YD------QEREEKIKQEQEDLELKHNSTLK--QLMREFNTQLAQKEQ---ELEMTIKET 2019
Query: 850 LMAMEKVKQE-LESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS 908
+ ++V+ E LES + + + + +AEK+ L K EE+L+ ++E + A +
Sbjct: 2020 INKAQEVEAELLESHQEETNQLLKKIAEKDDDL----KRTAKRYEEILDAREEEMTAKVR 2075
Query: 909 EKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADN 958
+ + L+ +K QEE + + +L+ Q + L++D+
Sbjct: 2076 DLQTQLEELQKKYQQKLEQEENPG---NDNVTIMELQTQLAQKTTLISDS 2122
Score = 132 bits (333), Expect = 1e-30
Identities = 185/798 (23%), Positives = 349/798 (43%), Gaps = 91/798 (11%)
Query: 347 ESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE-- 404
ESL KE S++R + T + +M DS+ + L +E
Sbjct: 82 ESLFRSSSKE-SLVRTSSRESLNRLDLDSSTASFDPPSDM-DSEAEDLVGNSDSLNKEQL 139
Query: 405 IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETL 464
IQ L+ + R + + + Y+ + K G + Q + + L+ +L+
Sbjct: 140 IQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQ-- 197
Query: 465 TNQFSDSKQHI-EVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLN--KKTKQIQDMA 521
+K+H+ E SL K+Q ++LQT+V L+ RL ++ K Q++ A
Sbjct: 198 --MDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQA 255
Query: 522 EEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT 581
E E + D V E +V K +E LQ++++ +E + KE ++S + T
Sbjct: 256 E---VFTKEENPESDGEPVVEDGTSV--KTLETLQQRVKRQENLLKRCKETIQSHKEQCT 310
Query: 582 NTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLS 641
+ L+E L E+ + +E++K+ ++ + ++ + K ++ L++ ++ +
Sbjct: 311 LLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETK 370
Query: 642 EKEASLLDLKEHASSLASSGLK---------KDSRLKTLEIALE---------QKKEEC- 682
+ L++KE + S +K ++ + K+ A E QK EE
Sbjct: 371 RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEAR 430
Query: 683 ----LKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ-AEVDRLLEIL 737
+M+ Q+K + + E R S + + +++E+ +SS+ Q A++ +L E
Sbjct: 431 RKLKAEMDEQIKTIEKTSEEERIS--LQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE-- 486
Query: 738 KEVENEKNDKDKKIAELERQVKDQNKKVAN------LKHKEQVEKKKSAQMLEEARRRED 791
KE+ ++ + KK+ ER+ ++Q K LK ++ E+++S + E +++
Sbjct: 487 KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 546
Query: 792 NLNDSSQQLQDSLRKKD---DRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEE 848
L +S +L+D ++ + RI ELE +L +S+Q + LA A N K +E
Sbjct: 547 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN--KHNKE 604
Query: 849 LLMAMEKVKQELESMK--------AKLSSTQQSL------------AEKETHLTNLRAER 888
+ + +EK K ELES+K KL +Q EKET L +
Sbjct: 605 ITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIF 664
Query: 889 RKHLEEVLEMKQEALLAAISEKDA-NIALLELSSSKKKTQEEVAALKREKDRLVQQLK-- 945
+ H+EE+ E E L +E ++ + L E+ ++ K +EE++ LK + D++ Q+L+
Sbjct: 665 QAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAK 724
Query: 946 -QQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTT 1004
+ +N + D+ +H S Q K DQI Q L L + LK + H+
Sbjct: 725 MDEQKNHHQQQVDSIIKEH---EVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVEN 781
Query: 1005 LCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTR------GQLQDELEKGERDNAEL 1058
L + D G AS LD Q ++++ + T+ QLQ +L E + L
Sbjct: 782 L--EADIKRSEGELQQASAKLDVFQ-SYQSATHEQTKAYEEQLAQLQQKLLDLETERILL 838
Query: 1059 QEFANAILQQIADHCPDI 1076
+ + Q D C ++
Sbjct: 839 TKQVAEVEAQKKDVCTEL 856
Score = 130 bits (327), Expect = 7e-30
Identities = 177/821 (21%), Positives = 373/821 (45%), Gaps = 98/821 (11%)
Query: 181 SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR 240
+S+ +++T +K++ L K I KEQ ++ E + +Q + EL +
Sbjct: 276 TSVKTLETL-QQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
Query: 241 DLNQLFQQD--SSSRTGEPCVAELTE-------ENFQRLHAEHERQAKELFLLRKTLEEM 291
DL+ + + R + + +L + E +++H E + +E+ LR +++M
Sbjct: 335 DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQM 394
Query: 292 ELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLE 351
+ E ++ +++S + E L+ +A+ TEE RR +AEM ++++ +
Sbjct: 395 TTQGEELREQ---KEKSERAAFEELEKALSTAQKTEE----ARRKLKAEMD-EQIKTIEK 446
Query: 352 QKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSN 411
E+E L++E+ R + D K + + + +++ + R ++L +++Q
Sbjct: 447 TSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQ----- 501
Query: 412 GALSTEERE-EEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTK--LETLTNQF 468
T ERE +E ++ + +S S+++K I Q K++ E L LQ K L N+
Sbjct: 502 ----TREREFQEQMKVALEKSQSEYLK--ISQEKEQQESLALEELELQKKAILTESENKL 555
Query: 469 SDSKQHIEVLK------ESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAE 522
D +Q E + ES K + Q++ A+ L E+ NK K+I M E
Sbjct: 556 RDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEK-----NKHNKEITVMVE 610
Query: 523 EKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDK--EKQMSSLKERVKSLQADT 580
+ T+ + +D L + K+ VL+++ + E+LR+K +++ + LK++ QA
Sbjct: 611 KHKTELESLKHQQDALWTE--KLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAH- 667
Query: 581 TNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDL 640
+EE E+T+E+L + + + E+ K L+E++S+L+
Sbjct: 668 ---------IEEM---NEKTLEKL-DVKQTELESLSSELSEVLKARHKLEEELSVLKDQT 714
Query: 641 S----EKEASLLDLKEHASSLASSGLKK-DSRLKTLEIALEQKKEECLKMESQLKKAHEA 695
E EA + + K H S +K+ + ++ E AL K++ ++E LK+ +
Sbjct: 715 DKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKAL---KDQINQLELLLKERDKH 771
Query: 696 ALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE 755
E +A +++LE +I R + E +A A++D + ++++A+L+
Sbjct: 772 LKEHQA------HVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQ 825
Query: 756 RQVKD-QNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 814
+++ D + +++ K +VE +K E L+ Q+QD +++ + + E+
Sbjct: 826 QKLLDLETERILLTKQVAEVEAQKKDVCTE--------LDAHKIQVQDLMQQLEKQNSEM 877
Query: 815 EEALRESVQITAER--EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 872
E+ ++ Q+ + + QE++ + EK+ +L E K+E+E + KLS+ +
Sbjct: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKE-NMILQMREGQKKEIEILTQKLSAKED 936
Query: 873 SL----AEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI------ALLELSSS 922
S+ E ET N + K ++ EM QE L + +++A + LELS
Sbjct: 937 SIHILNEEYETKFKNQEKKMEKVKQKAKEM-QETLKKKLLDQEAKLKKELENTALELSQK 995
Query: 923 KKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDH 963
+K+ ++ + + + + + K ++ + H
Sbjct: 996 EKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVH 1036
Score = 110 bits (274), Expect = 9e-24
Identities = 154/729 (21%), Positives = 322/729 (44%), Gaps = 105/729 (14%)
Query: 149 NTIMDLQTQLKEVLRENDLLRKDVEVKESKLS-SSMNSIKTFWSPELKKERA-LRKDEAS 206
NT+ +LQ QL+ L+ + KD ++ K N E++ +++ + K E++
Sbjct: 1458 NTVKELQIQLE--LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESN 1515
Query: 207 KITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTE-- 264
T K Q + E H+ ++ + ++ NQ Q+D + EL +
Sbjct: 1516 LETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ--QKDIEHK-------ELVQKL 1566
Query: 265 ENFQRLHAEHERQAKE----LFLLRKTLEEMELRIETQKQTLN-------ARDESIKKLL 313
++FQ L E + + KE + L + M+ +ET+K+ L +++E +K L
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
Query: 314 EMLQSKGLSAKATEEDHERTRRLAE-------------------AEMHVHHLESLLEQKE 354
+ L+S+ +AK E + +++A E H+ L + L+++E
Sbjct: 1627 DRLESES-AAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERE 1685
Query: 355 KENSMLREEMHRRFENA-------PDSAKTKALQTVIEMKDS----------KISSMERG 397
+E +L E++ + E++ P SAK A T E DS KIS ++R
Sbjct: 1686 REVHILEEKL-KSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRN 1744
Query: 398 LRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLAL 457
L + E+ +Q + +E+EE + R + K+ + + + + L
Sbjct: 1745 LTEKEKLLQRVG-------QEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHL 1797
Query: 458 QTKLETLTNQFS-DSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET---MLNKK 513
Q +LE ++S QH+E KE Q L+ D ++ L+EKE +L +K
Sbjct: 1798 QEELEEKNKKYSLIVAQHVE--KEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQK 1855
Query: 514 TKQIQD-MAEEKGTQAGEIHDLKDMLDVKERKVNVLQ------KKIENLQEQLRDKEKQM 566
K++ + +K E+ +L K K+ LQ K E L+E +K K
Sbjct: 1856 IKELDSCLVRQKEVHRVEMEELTS----KYEKLQALQQMDGRNKPTELLEENTEEKSKSH 1911
Query: 567 SSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDL 626
+ + +++A + + L E + + I RL++ +E Q+E++ KK+
Sbjct: 1912 LVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEY 1971
Query: 627 -KDLKEKVSLLQGDLSEKEASLLD--LKEHASSLASSGLKKDSRLKTLEIALEQKKEECL 683
++ +EK+ Q DL K S L ++E + LA + + LE+ +++ +
Sbjct: 1972 DQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQ-------KEQELEMTIKETINKAQ 2024
Query: 684 KMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENE 743
++E++L ++H+ + +++++ L+R RY++ A + + +++++ +
Sbjct: 2025 EVEAELLESHQEETN-QLLKKIAEKDDDLKRTAKRYEEI---LDAREEEMTAKVRDLQTQ 2080
Query: 744 KNDKDKKIAE-LERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQD 802
+ KK + LE++ N V ++ + Q+ +K + ++ +++ +E + L+D
Sbjct: 2081 LEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTT--LISDSKLKEQEFREQIHNLED 2138
Query: 803 SLRKKDDRI 811
L+K + +
Sbjct: 2139 RLKKYEKNV 2147
Score = 84.0 bits (206), Expect = 7e-16
Identities = 137/662 (20%), Positives = 291/662 (43%), Gaps = 97/662 (14%)
Query: 143 LRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRK 202
L + +DN + + + ++ + + ++ ++E K+ +L S+K+ E L
Sbjct: 1572 LGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLES 1631
Query: 203 DEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAEL 262
+ A+K+ E + + I A++ +L L+Q+ +++ + G
Sbjct: 1632 ESAAKLA----------ELKRKAEQKIAAIKKQL-----LSQMEEKEEQYKKG------- 1669
Query: 263 TEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTL----NARDESIKKLLEMLQS 318
TE + L+ + + + +E+ +L + L+ +E +Q +TL +A++ + E S
Sbjct: 1670 TESHLSELNTKLQEREREVHILEEKLKSVE---SSQSETLIVPRSAKNVAAYTEQEEADS 1726
Query: 319 KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTK 378
+G K EE +++ + ++ E LL++ +E E + FE +
Sbjct: 1727 QGCVQKTYEE------KISVLQRNLTEKEKLLQRVGQEK---EETVSSHFEMRCQYQERL 1777
Query: 379 ALQTVIEMKDSKISSMERGLRDLEEEI-QMLKSNGALSTEEREEEMKQMEVYRSHSKFMK 437
E K + SM + L+EE+ + K + + E+E + + + ++
Sbjct: 1778 IKLEHAEAKQHEDQSM---IGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQN--LE 1832
Query: 438 NKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVD 497
N V++ L K+ L+ K++ L + K+ V E LT+K ++ LQ ++D
Sbjct: 1833 NVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQ-QMD 1891
Query: 498 ALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE 557
NK T+ +++ EEK K L V+ + ++ ++ + +L+
Sbjct: 1892 G-----------RNKPTELLEENTEEKS---------KSHL-VQPKLLSNMEAQHNDLEF 1930
Query: 558 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD--RDEREK 615
+L E++ L + + LQ D L E ++ +E LK++ D R+E+ K
Sbjct: 1931 KLAGAEREKQKLGKEIVRLQKD----------LRMLRKEHQQELEILKKEYDQEREEKIK 1980
Query: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASL-LDLKE---HASSLASSGLKKDSRLKTL 671
QE+ D K LK+ + L++KE L + +KE A + + L+
Sbjct: 1981 QEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQ 2040
Query: 672 EIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD 731
+ +K++ LK + K +E L+AR EM+ +++ L+ T+ ++ K Q +
Sbjct: 2041 LLKKIAEKDDDLK---RTAKRYEEILDAR-EEEMTAKVRDLQ---TQLEELQKKYQQK-- 2091
Query: 732 RLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRED 791
L++ EN ND + I EL+ Q+ + +++ K KEQ +++ + + ++ E
Sbjct: 2092 -----LEQEENPGND-NVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEK 2145
Query: 792 NL 793
N+
Sbjct: 2146 NV 2147
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 149 bits (375), Expect = 2e-35
Identities = 195/896 (21%), Positives = 385/896 (42%), Gaps = 122/896 (13%)
Query: 154 LQTQLK---EVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL---RKDEASK 207
LQ QL+ E+ E + +R + K+ +L ++ ++ E + + L RK A +
Sbjct: 892 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951
Query: 208 ITIWKEQYRVVQEENQHMQMT-------IQALQDELRIQRDLN-------QLFQQDSSSR 253
+ +EQ + Q +Q+ I+ L+DE+ + D N +L ++ S
Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011
Query: 254 TGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 313
T E +N +L +HE EL + K E+ +E K+ L + +
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 314 EMLQS-----KGLSAKATEE--------------DHERTRRLAEAEMHVHHLESLLEQK- 353
LQ+ K AK EE + +++ E E H+ L+ L+ +
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 354 ------EKENSMLREEMHRRFENAPDSAKTKALQTVIEMK-DSKISSMERGL----RDLE 402
EK+ L EE+ D+ + A Q + K + +++ +++ L R E
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Query: 403 EEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNK----------------IGQVKQE 446
++Q ++ A + EE E+++Q + R+ + KNK +GQ KQE
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFK--RAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249
Query: 447 LSRKDTELLALQTKLET-----------LTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 495
+ K +L A +L++ L ++ + +E + L E +A L +
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 496 VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL 555
V +L +L++ + +L ++T+Q +++ + E + L+D LD + L++ I L
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 556 QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREK 615
QL D +K++ V++L+ + L + EK ++L++ ++R
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR----L 1425
Query: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 675
Q+E+D+ DL + ++ VS L+ + + L + K +S A D R + E
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA------DERDRA-EAEA 1478
Query: 676 EQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLERE-ITRYKDESSKAQAEVDRLL 734
+K+ + L L +A E ALEA+ E ++++ E E + KD+ K V L
Sbjct: 1479 REKETKAL----SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK---NVHELE 1531
Query: 735 EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 794
+ + +E + + ++ ELE +++ L+ Q K Q + + R++
Sbjct: 1532 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK---GQFERDLQARDEQNE 1588
Query: 795 DSSQQLQDSLRKKDDRIEE--LEEALRESVQITAEREM--VLAQEESA---RTNAEKQVE 847
+ +QLQ L + + +E+ + AL + + E ++ + Q +SA R A KQ+
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648
Query: 848 ELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAI 907
+L M+ ++ELE +A + E E +L A ++++++++ A
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-------DLMQLQEDLAAAER 1701
Query: 908 SEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ------QTQNRMKLMAD 957
+ K A++ EL+ + AL+ EK RL ++ Q + Q M+ M+D
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Score = 144 bits (364), Expect = 3e-34
Identities = 211/936 (22%), Positives = 398/936 (42%), Gaps = 150/936 (16%)
Query: 229 IQALQDEL-----RIQRDLNQL--FQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKEL 281
+QA +DEL R Q+ N+L +Q S T E + + + L+AE
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE-------- 905
Query: 282 FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRL-AEAE 340
EEM +R+ +KQ L +++L ++++ EE+ +R ++L AE +
Sbjct: 906 ------AEEMRVRLAAKKQEL-------EEILHEMEAR------LEEEEDRGQQLQAERK 946
Query: 341 MHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD 400
+ L EQ E+E + R+++ + E AK K L+ I + D + + + + +
Sbjct: 947 KMAQQMLDLEEQLEEEEA-ARQKL--QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1003
Query: 401 LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKN-KIGQVKQELSRKDTELL--AL 457
LEE I L +N A EE E+ ++ H + ++ K+E SR++ E L L
Sbjct: 1004 LEERISDLTTNLA---EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 458 QTKLETLTNQFSDSKQHIEVLKESLTAKEQ--RAAI-------------------LQTEV 496
+ Q +D + I LK L KE+ +AA+ L+ +
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 497 DALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKD-------MLDVKERKVNVLQ 549
L+ L+ + NK KQ +D+ EE E+ D D + +E++V VL+
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 550 KKIE--------NLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE--------- 592
K ++ +QE + + + L E+++ + N D TLE+
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240
Query: 593 -ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQ-------GDLSEKE 644
L + ++ +E K++ + +E Q + + ++ +L +KV LQ G L+E E
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 645 ASLLDLKEHASSLAS------SGLKKDSRLK-TLEIALEQKKEECLKMESQLKKAHEAA- 696
+ L + +SL+S L++++R K + L Q +EE ++ QL + EA
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Query: 697 -LEARASP---EMSD---RIQHLEREITRYKDESSKAQAEVDRLLEILKE-------VEN 742
LE S ++SD ++Q + ++ + Q E++ L + +E +E
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 743 EKNDKDKKIAELERQVKDQNKKVANLKHKEQ-------VEKKKSAQMLEEARRREDNLND 795
KN +++ +L + +Q + V+NL+ K++ EK S++ +E R E +
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 796 SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA---EKQVEELLMA 852
+ R ++ +E EE R + + AE E +++ ++ N EK L
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 853 MEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHL---EEVLEMKQEALLAAISE 909
ME++K +LE ++ +L +T+ + E ++ L+ + + L +E E K+ L + E
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 910 -----KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHF 964
+D +++KKK + ++ L+ + D ++ ++ + KL A
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA------QM 1654
Query: 965 KSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYN 1024
K + + S D+I E N K K L L D + +
Sbjct: 1655 KDFQRELEDARASRDEIFATAKE---NEKKAKSLEADLMQLQED----LAAAERARKQAD 1707
Query: 1025 LDDDQAAWENELQKMTRGQLQDELEKGERDNAELQE 1060
L+ ++ A E R LQDE + E A+L+E
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743
Score = 130 bits (328), Expect = 5e-30
Identities = 189/869 (21%), Positives = 374/869 (43%), Gaps = 152/869 (17%)
Query: 151 IMDLQTQLKEVLRENDLLRKDVEVK------ESKLSSSMNSIKTFWSPE---------LK 195
I DLQ Q+ E+ + L +K+ E++ + +++ N++K E L
Sbjct: 1071 IADLQAQIAELKMQ--LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 196 KERALR-KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQ---DSS 251
ERA R K E K + +E + E + T A Q ELR +R+ + D
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEVTVLKKALDEE 1186
Query: 252 SRTGEPCVAELTEENFQRLHA------EHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
+R+ E V E+ +++ Q + + +R L ++TLE+ + + + L
Sbjct: 1187 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 306 DESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
+ ++ + L+++ ++ D ER R AE VH L++ + E ML E
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQN---EVESVTGMLNEAEG 1301
Query: 366 RRFENAPD----SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE 421
+ + A D S++ + Q +++ + + ++ LR LEEE L+ ++ +E
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ-------DQLDE 1354
Query: 422 EMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLAL-------QTKLETLTNQFSDSKQH 474
EM+ + H + ++ K++L + + AL Q ++E LT Q+ +
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 475 IEVLKESLTAKEQRAAILQTEVDALRL---RLEEK----------ETMLNKKTKQIQDMA 521
+ L+++ +Q L ++D R LE+K E ++ K +D A
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474
Query: 522 E----EKGTQAGEI-HDLKDMLDVKE---RKVNVLQ--------------KKIENLQEQL 559
E EK T+A + L++ L+ KE R +L+ K + L++
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534
Query: 560 RDKEKQMSSLKERVKSLQADTTNTDTALTTLE---EAL-AEKERTIERLKEQRDRDEREK 615
R E QM +K +++ L+ + T+ A LE +AL + ER ++ EQ + R+
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594
Query: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 675
Q ++ Y+ +L+D +++ +L + E L DL+ L+ DS +K E A+
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE----------LQADSAIKGREEAI 1644
Query: 676 EQKKEECLKMESQLKKAHEAALEARAS--------PEMSDRIQHLEREITRYKDE---SS 724
+Q + K+++Q+K +ARAS E + + LE ++ + +++ +
Sbjct: 1645 KQLR----KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 725 KAQAEVDRLLEILKE-----------VENEKNDKDKKIAELERQVKDQNKKVANLKHK-- 771
+A+ + D E L E +++EK + +IA+LE +++++ + + +
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 772 -----------EQVEKKKSAQMLEEAR----RREDNLNDSSQQLQDSLRKK--------D 808
E ++ +AQ E AR R+ L +++ +++ K +
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1820
Query: 809 DRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLS 868
+I +LEE + + + L Q++ QVE+ E+ K++ E A++
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1880
Query: 869 STQQSLAEKETHLTNLRAERRKHLEEVLE 897
++ L E E + A RRK E+ E
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDE 1909
Score = 119 bits (298), Expect = 2e-26
Identities = 182/806 (22%), Positives = 357/806 (44%), Gaps = 112/806 (13%)
Query: 136 ASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESK----LSSSMNSIKTFWS 191
++ LR R+ + L+ L E R ++ +++ K ++ L+ + K +
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Query: 192 PELKKERALRK---DEASKITIWKEQYRVVQEENQHMQMTIQALQ----DELRIQRDLNQ 244
K ++ L K D A ++ + + + V+ + + ++ +Q LQ D R + +LN
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 245 L---FQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQT 301
Q + S TG AE + A Q ++ L + +L + T+ +
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 302 LNARDESIKKLLEMLQSKGLSAKATEEDHERTR--RLAEAEMHVHHLESLLE-------- 351
L S++ L+ + + AK E H T +L++++ + S +E
Sbjct: 1341 LEEERNSLQDQLD----EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396
Query: 352 -QKEKENSMLREE----MHRRFENAPDSAKTKALQTVIEMKDSK--ISSMERGLRDLEEE 404
QKE EN + E + + E + + + V+++ + + +S++E+ R ++
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456
Query: 405 IQMLKSNGALSTEER--------EEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLA 456
+ K+ + +ER E+E K + + R+ + + + K+EL R + L A
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-----EAKEELERTNKMLKA 1511
Query: 457 LQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQ 516
++E L + D +++ L++S A E + ++T+++ L L+ E + K +
Sbjct: 1512 ---EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE---DAKLRL 1565
Query: 517 IQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSL 576
+M KG DL+ + E K LQ+++ + +L D+ KQ + K L
Sbjct: 1566 EVNMQALKGQFE---RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Query: 577 QADTTN----TDTALTTLEEALAEKERTIERLKE-QRD-RDEREKQEEI-----DNYKKD 625
+ D + D+A+ EEA+ + + ++K+ QR+ D R ++EI +N KK
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK- 1681
Query: 626 LKDLKEKVSLLQGDLS--EKEASLLDLK------EHASSLASSGLKKDSRLKTLEIALEQ 677
K L+ + LQ DL+ E+ DL+ E ASSL+ +D + + LE + Q
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK-RRLEARIAQ 1740
Query: 678 KKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDR--LLE 735
+EE + + ++ + +A E ER T K+ES++ Q E L
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS-TAQKNESARQQLERQNKELRS 1799
Query: 736 ILKEVENEKNDKDK--------KIAELERQVKDQ-NKKVANLKHKEQVEKKKSAQMLEEA 786
L E+E K K KIA+LE QV+ + +K A K +Q +KK L+E
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK-----LKEI 1854
Query: 787 RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA---- 842
+ ++ ++Q ++ K + R+++L+ L E A+EES R NA
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE------------AEEESQRINANRRK 1902
Query: 843 -EKQVEELLMAMEKVKQELESMKAKL 867
+++++E + E + +E+ ++K+KL
Sbjct: 1903 LQRELDEATESNEAMGREVNALKSKL 1928
Score = 115 bits (289), Expect = 2e-25
Identities = 169/803 (21%), Positives = 349/803 (43%), Gaps = 106/803 (13%)
Query: 345 HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE 404
HLE + K + M + M R + AK + T +++ ++ + LR+ +
Sbjct: 777 HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK-LRNWQWW 835
Query: 405 IQMLKSNGALSTEEREEEM--KQMEVYRSHSKFMK--NKIGQVKQELSRKDTELLALQTK 460
K L +EEEM K+ E+ ++ + K N++ +++Q+ S+ E LQ +
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 461 LETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDM 520
L+ T ++++++ ++ L AK+Q + E++A RLEE+E + Q +
Sbjct: 896 LQAETELYAEAEE----MRVRLAAKKQELEEILHEMEA---RLEEEED-------RGQQL 941
Query: 521 AEEKGTQAGEIHDLKDMLDVKERKVNVLQ-------KKIENLQEQLRDKEKQMSSLKERV 573
E+ A ++ DL++ L+ +E LQ KI+ L++++ + Q + L +
Sbjct: 942 QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001
Query: 574 KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV 633
K L+ ++ T L E EK + + +LK + + E + + +K ++L++
Sbjct: 1002 KLLEERISDLTTNLAEEE----EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK 1057
Query: 634 SLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAH 693
L+GD S+ + DL+ + L KK+ + L+ AL + +E + + LKK
Sbjct: 1058 RKLEGDASDFHEQIADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQKNNALKKIR 1114
Query: 694 ---------------EAALEARASPEMSDRIQHLEREITRYKD--ESSKAQAEV----DR 732
E A +A + D + LE T +D +S+ Q E+ ++
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1174
Query: 733 LLEILK------------EVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSA 780
+ +LK +V+ + + + EL Q++ + ANL +Q +K++A
Sbjct: 1175 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1234
Query: 781 QMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESART 840
+ E R L + Q+++ +K + +++EL+ + + AE + + ++
Sbjct: 1235 DLAGELR----VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 841 NAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEK-------ETHLTNLRAER---RK 890
+ + E K+ +++ S+ ++L TQ+ L E+ T L L ER +
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1350
Query: 891 HLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQE---EVAALKREKDRLVQQLKQQ 947
L+E +E KQ E+ + ++LS SKKK Q+ V AL+ K R ++++
Sbjct: 1351 QLDEEMEAKQNL------ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 948 TQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCH 1007
TQ YE+ +T ++ ++ +++LD R + +L
Sbjct: 1405 TQ--------QYEEKAAAYDKLEKTKNR-LQQELDDLVVDLDNQRQ----LVSNLEKKQR 1451
Query: 1008 DRDPLILRGLTPPASYNLDDDQA---AWENELQKMTRGQLQDELEKGERDNAELQEFANA 1064
D L+ + Y + D+A A E E + ++ + +E + + + + A
Sbjct: 1452 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKA 1511
Query: 1065 ILQQIADHCPDILEQVVNALEES 1087
++ + D+ + V+ LE+S
Sbjct: 1512 EMEDLVSSKDDVGKN-VHELEKS 1533
Score = 110 bits (274), Expect = 9e-24
Identities = 140/708 (19%), Positives = 299/708 (42%), Gaps = 117/708 (16%)
Query: 142 SLRQARDNTIMDLQTQ-LKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL 200
+++ A+D + Q Q +E+L+E + +V K +L NS++ E++ ++ L
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Query: 201 RKDEASKITIWKEQYRVVQEENQHMQMTIQALQD-ELRIQRDLNQLFQQDSSSRTGEPCV 259
+ I+ Q +++ Q T++AL++ + R Q+++ L QQ
Sbjct: 1363 ERH----ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ----------- 1407
Query: 260 AELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEML-QS 318
++ A +++ K L++ L+++ + ++ Q+Q ++ ++ +K ++L +
Sbjct: 1408 -------YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460
Query: 319 KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTK 378
K +S+K +E R AEAE +EKE L + +
Sbjct: 1461 KNISSKYADE-----RDRAEAEA-----------REKETKAL--------------SLAR 1490
Query: 379 ALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKN 438
AL+ +E K+ +ER + L+ E++ L S+ + E K + + MK
Sbjct: 1491 ALEEALEAKEE----LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 439 KIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDA 498
++ +++ EL + L L+ ++ L QF Q + E + QR
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR---------- 1596
Query: 499 LRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQ 558
+L E ET L + KQ A K G++ DL+ D + K++ LQ Q
Sbjct: 1597 ---QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653
Query: 559 LRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI---ERLKEQRDRDEREK 615
++D ++++ + + A + +LE L + + + ER ++Q D ++ E
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 675
EE+ + L+++ L+ +++ E L + + + +++ K + + L L
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 676 EQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREI-TRYKDESSKAQAEVDRLL 734
++ K ES ++ R + E+ ++ +E + +++K + +A++ +L
Sbjct: 1774 ATERSTAQKNESARQQLE------RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1827
Query: 735 EILKEVENEKN-------DKDKKIAELERQVKDQNKKVANLKHKEQVEK----------- 776
E +++ EK KDKK+ E+ QV+D+ K ++KEQ EK
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE--QYKEQAEKGNARVKQLKRQ 1885
Query: 777 ---------------KKSAQMLEEARRREDNLNDSSQQLQDSLRKKDD 809
+K + L+EA + + L+ LR+ ++
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 90.1 bits (222), Expect = 1e-17
Identities = 141/675 (20%), Positives = 271/675 (40%), Gaps = 104/675 (15%)
Query: 139 VPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSP--ELKK 196
V LRQ + LQ QL E + L + + +LS S ++ F S L++
Sbjct: 1334 VSTKLRQLEEER-NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Query: 197 ERALRKDEASKITIWKEQ----YRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSS 252
+ + E +T E+ Y +++ +Q + L +L QR L + +
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL--VSNLEKKQ 1450
Query: 253 RTGEPCVAELTEENFQRLHAEH---------ERQAKELFLLRKTLEEMELRIETQKQT-- 301
R + +AE E+N +A+ E++ K L L R E +E + E ++
Sbjct: 1451 RKFDQLLAE--EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Query: 302 --------LNARDESIKKLLEMLQSK-GLSAKATE--------EDHERTRRLAEAEMHVH 344
++++D+ K + E+ +SK L + E ED + A+ + V+
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568
Query: 345 ----------HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMK------- 387
L++ EQ E++ L+ ++H D K +AL + K
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 388 -----DSKISSMERGLRDLEE-EIQMLKSNGAL--STEEREEEMKQMEVYRSHSKFMKNK 439
DS I E ++ L + + QM L + R+E + +K ++
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688
Query: 440 IGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDAL 499
+ Q++++L+ + + E L + + S L++ E R A L+ E++
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748
Query: 500 RLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQL 559
+ +E + K T+Q + ++ E T+ +K ++++E ++L
Sbjct: 1749 QGNMEAMSDRVRKATQQAEQLSNELATERS-----------TAQKNESARQQLERQNKEL 1797
Query: 560 RDKEKQM-SSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEE 618
R K +M ++K + KS +A E I +L+EQ +++ REKQ
Sbjct: 1798 RSKLHEMEGAVKSKFKS-----------------TIAALEAKIAQLEEQVEQEAREKQAA 1840
Query: 619 IDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQK 678
+ K+ KD K K LLQ + K A KE A K ++R+K L+ LE+
Sbjct: 1841 TKSLKQ--KDKKLKEILLQVEDERKMAE--QYKEQAE-------KGNARVKQLKRQLEEA 1889
Query: 679 KEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILK 738
+EE ++ + +K EA S E R + + R +E+S + +++
Sbjct: 1890 EEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1949
Query: 739 EVENEKNDKDKKIAE 753
+ + + D + A+
Sbjct: 1950 NADGSEEETDTRDAD 1964
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 149 bits (375), Expect = 2e-35
Identities = 195/896 (21%), Positives = 385/896 (42%), Gaps = 122/896 (13%)
Query: 154 LQTQLK---EVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL---RKDEASK 207
LQ QL+ E+ E + +R + K+ +L ++ ++ E + + L RK A +
Sbjct: 899 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958
Query: 208 ITIWKEQYRVVQEENQHMQMT-------IQALQDELRIQRDLN-------QLFQQDSSSR 253
+ +EQ + Q +Q+ I+ L+DE+ + D N +L ++ S
Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
Query: 254 TGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 313
T E +N +L +HE EL + K E+ +E K+ L + +
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 314 EMLQS-----KGLSAKATEE--------------DHERTRRLAEAEMHVHHLESLLEQK- 353
LQ+ K AK EE + +++ E E H+ L+ L+ +
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 354 ------EKENSMLREEMHRRFENAPDSAKTKALQTVIEMK-DSKISSMERGL----RDLE 402
EK+ L EE+ D+ + A Q + K + +++ +++ L R E
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Query: 403 EEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNK----------------IGQVKQE 446
++Q ++ A + EE E+++Q + R+ + KNK +GQ KQE
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFK--RAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256
Query: 447 LSRKDTELLALQTKLET-----------LTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 495
+ K +L A +L++ L ++ + +E + L E +A L +
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 496 VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL 555
V +L +L++ + +L ++T+Q +++ + E + L+D LD + L++ I L
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 556 QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREK 615
QL D +K++ V++L+ + L + EK ++L++ ++R
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR----L 1432
Query: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 675
Q+E+D+ DL + ++ VS L+ + + L + K +S A D R + E
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA------DERDRA-EAEA 1485
Query: 676 EQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLERE-ITRYKDESSKAQAEVDRLL 734
+K+ + L L +A E ALEA+ E ++++ E E + KD+ K V L
Sbjct: 1486 REKETKAL----SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK---NVHELE 1538
Query: 735 EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 794
+ + +E + + ++ ELE +++ L+ Q K Q + + R++
Sbjct: 1539 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK---GQFERDLQARDEQNE 1595
Query: 795 DSSQQLQDSLRKKDDRIEE--LEEALRESVQITAEREM--VLAQEESA---RTNAEKQVE 847
+ +QLQ L + + +E+ + AL + + E ++ + Q +SA R A KQ+
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655
Query: 848 ELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAI 907
+L M+ ++ELE +A + E E +L A ++++++++ A
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-------DLMQLQEDLAAAER 1708
Query: 908 SEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ------QTQNRMKLMAD 957
+ K A++ EL+ + AL+ EK RL ++ Q + Q M+ M+D
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Score = 144 bits (364), Expect = 3e-34
Identities = 211/936 (22%), Positives = 398/936 (42%), Gaps = 150/936 (16%)
Query: 229 IQALQDEL-----RIQRDLNQL--FQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKEL 281
+QA +DEL R Q+ N+L +Q S T E + + + L+AE
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE-------- 912
Query: 282 FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRL-AEAE 340
EEM +R+ +KQ L +++L ++++ EE+ +R ++L AE +
Sbjct: 913 ------AEEMRVRLAAKKQEL-------EEILHEMEAR------LEEEEDRGQQLQAERK 953
Query: 341 MHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD 400
+ L EQ E+E + R+++ + E AK K L+ I + D + + + + +
Sbjct: 954 KMAQQMLDLEEQLEEEEA-ARQKL--QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1010
Query: 401 LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKN-KIGQVKQELSRKDTELL--AL 457
LEE I L +N A EE E+ ++ H + ++ K+E SR++ E L L
Sbjct: 1011 LEERISDLTTNLA---EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 458 QTKLETLTNQFSDSKQHIEVLKESLTAKEQ--RAAI-------------------LQTEV 496
+ Q +D + I LK L KE+ +AA+ L+ +
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 497 DALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKD-------MLDVKERKVNVLQ 549
L+ L+ + NK KQ +D+ EE E+ D D + +E++V VL+
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 550 KKIE--------NLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE--------- 592
K ++ +QE + + + L E+++ + N D TLE+
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247
Query: 593 -ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQ-------GDLSEKE 644
L + ++ +E K++ + +E Q + + ++ +L +KV LQ G L+E E
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 645 ASLLDLKEHASSLAS------SGLKKDSRLK-TLEIALEQKKEECLKMESQLKKAHEAA- 696
+ L + +SL+S L++++R K + L Q +EE ++ QL + EA
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 697 -LEARASP---EMSD---RIQHLEREITRYKDESSKAQAEVDRLLEILKE-------VEN 742
LE S ++SD ++Q + ++ + Q E++ L + +E +E
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 743 EKNDKDKKIAELERQVKDQNKKVANLKHKEQ-------VEKKKSAQMLEEARRREDNLND 795
KN +++ +L + +Q + V+NL+ K++ EK S++ +E R E +
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 796 SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA---EKQVEELLMA 852
+ R ++ +E EE R + + AE E +++ ++ N EK L
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 853 MEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHL---EEVLEMKQEALLAAISE 909
ME++K +LE ++ +L +T+ + E ++ L+ + + L +E E K+ L + E
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 910 -----KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHF 964
+D +++KKK + ++ L+ + D ++ ++ + KL A
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA------QM 1661
Query: 965 KSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYN 1024
K + + S D+I E N K K L L D + +
Sbjct: 1662 KDFQRELEDARASRDEIFATAKE---NEKKAKSLEADLMQLQED----LAAAERARKQAD 1714
Query: 1025 LDDDQAAWENELQKMTRGQLQDELEKGERDNAELQE 1060
L+ ++ A E R LQDE + E A+L+E
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750
Score = 130 bits (328), Expect = 5e-30
Identities = 189/869 (21%), Positives = 374/869 (43%), Gaps = 152/869 (17%)
Query: 151 IMDLQTQLKEVLRENDLLRKDVEVK------ESKLSSSMNSIKTFWSPE---------LK 195
I DLQ Q+ E+ + L +K+ E++ + +++ N++K E L
Sbjct: 1078 IADLQAQIAELKMQ--LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 196 KERALR-KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQ---DSS 251
ERA R K E K + +E + E + T A Q ELR +R+ + D
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEVTVLKKALDEE 1193
Query: 252 SRTGEPCVAELTEENFQRLHA------EHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
+R+ E V E+ +++ Q + + +R L ++TLE+ + + + L
Sbjct: 1194 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 306 DESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
+ ++ + L+++ ++ D ER R AE VH L++ + E ML E
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQN---EVESVTGMLNEAEG 1308
Query: 366 RRFENAPD----SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE 421
+ + A D S++ + Q +++ + + ++ LR LEEE L+ ++ +E
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ-------DQLDE 1361
Query: 422 EMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLAL-------QTKLETLTNQFSDSKQH 474
EM+ + H + ++ K++L + + AL Q ++E LT Q+ +
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 475 IEVLKESLTAKEQRAAILQTEVDALRL---RLEEK----------ETMLNKKTKQIQDMA 521
+ L+++ +Q L ++D R LE+K E ++ K +D A
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481
Query: 522 E----EKGTQAGEI-HDLKDMLDVKE---RKVNVLQ--------------KKIENLQEQL 559
E EK T+A + L++ L+ KE R +L+ K + L++
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541
Query: 560 RDKEKQMSSLKERVKSLQADTTNTDTALTTLE---EAL-AEKERTIERLKEQRDRDEREK 615
R E QM +K +++ L+ + T+ A LE +AL + ER ++ EQ + R+
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601
Query: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 675
Q ++ Y+ +L+D +++ +L + E L DL+ L+ DS +K E A+
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE----------LQADSAIKGREEAI 1651
Query: 676 EQKKEECLKMESQLKKAHEAALEARAS--------PEMSDRIQHLEREITRYKDE---SS 724
+Q + K+++Q+K +ARAS E + + LE ++ + +++ +
Sbjct: 1652 KQLR----KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 725 KAQAEVDRLLEILKE-----------VENEKNDKDKKIAELERQVKDQNKKVANLKHK-- 771
+A+ + D E L E +++EK + +IA+LE +++++ + + +
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 772 -----------EQVEKKKSAQMLEEAR----RREDNLNDSSQQLQDSLRKK--------D 808
E ++ +AQ E AR R+ L +++ +++ K +
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1827
Query: 809 DRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLS 868
+I +LEE + + + L Q++ QVE+ E+ K++ E A++
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1887
Query: 869 STQQSLAEKETHLTNLRAERRKHLEEVLE 897
++ L E E + A RRK E+ E
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDE 1916
Score = 119 bits (298), Expect = 2e-26
Identities = 182/806 (22%), Positives = 357/806 (44%), Gaps = 112/806 (13%)
Query: 136 ASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESK----LSSSMNSIKTFWS 191
++ LR R+ + L+ L E R ++ +++ K ++ L+ + K +
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227
Query: 192 PELKKERALRK---DEASKITIWKEQYRVVQEENQHMQMTIQALQ----DELRIQRDLNQ 244
K ++ L K D A ++ + + + V+ + + ++ +Q LQ D R + +LN
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 245 L---FQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQT 301
Q + S TG AE + A Q ++ L + +L + T+ +
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 302 LNARDESIKKLLEMLQSKGLSAKATEEDHERTR--RLAEAEMHVHHLESLLE-------- 351
L S++ L+ + + AK E H T +L++++ + S +E
Sbjct: 1348 LEEERNSLQDQLD----EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403
Query: 352 -QKEKENSMLREE----MHRRFENAPDSAKTKALQTVIEMKDSK--ISSMERGLRDLEEE 404
QKE EN + E + + E + + + V+++ + + +S++E+ R ++
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463
Query: 405 IQMLKSNGALSTEER--------EEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLA 456
+ K+ + +ER E+E K + + R+ + + + K+EL R + L A
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-----EAKEELERTNKMLKA 1518
Query: 457 LQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQ 516
++E L + D +++ L++S A E + ++T+++ L L+ E + K +
Sbjct: 1519 ---EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE---DAKLRL 1572
Query: 517 IQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSL 576
+M KG DL+ + E K LQ+++ + +L D+ KQ + K L
Sbjct: 1573 EVNMQALKGQFE---RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Query: 577 QADTTN----TDTALTTLEEALAEKERTIERLKE-QRD-RDEREKQEEI-----DNYKKD 625
+ D + D+A+ EEA+ + + ++K+ QR+ D R ++EI +N KK
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK- 1688
Query: 626 LKDLKEKVSLLQGDLS--EKEASLLDLK------EHASSLASSGLKKDSRLKTLEIALEQ 677
K L+ + LQ DL+ E+ DL+ E ASSL+ +D + + LE + Q
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK-RRLEARIAQ 1747
Query: 678 KKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDR--LLE 735
+EE + + ++ + +A E ER T K+ES++ Q E L
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS-TAQKNESARQQLERQNKELRS 1806
Query: 736 ILKEVENEKNDKDK--------KIAELERQVKDQ-NKKVANLKHKEQVEKKKSAQMLEEA 786
L E+E K K KIA+LE QV+ + +K A K +Q +KK L+E
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK-----LKEI 1861
Query: 787 RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA---- 842
+ ++ ++Q ++ K + R+++L+ L E A+EES R NA
Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE------------AEEESQRINANRRK 1909
Query: 843 -EKQVEELLMAMEKVKQELESMKAKL 867
+++++E + E + +E+ ++K+KL
Sbjct: 1910 LQRELDEATESNEAMGREVNALKSKL 1935
Score = 115 bits (289), Expect = 2e-25
Identities = 169/803 (21%), Positives = 349/803 (43%), Gaps = 106/803 (13%)
Query: 345 HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE 404
HLE + K + M + M R + AK + T +++ ++ + LR+ +
Sbjct: 784 HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK-LRNWQWW 842
Query: 405 IQMLKSNGALSTEEREEEM--KQMEVYRSHSKFMK--NKIGQVKQELSRKDTELLALQTK 460
K L +EEEM K+ E+ ++ + K N++ +++Q+ S+ E LQ +
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 461 LETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDM 520
L+ T ++++++ ++ L AK+Q + E++A RLEE+E + Q +
Sbjct: 903 LQAETELYAEAEE----MRVRLAAKKQELEEILHEMEA---RLEEEED-------RGQQL 948
Query: 521 AEEKGTQAGEIHDLKDMLDVKERKVNVLQ-------KKIENLQEQLRDKEKQMSSLKERV 573
E+ A ++ DL++ L+ +E LQ KI+ L++++ + Q + L +
Sbjct: 949 QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008
Query: 574 KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV 633
K L+ ++ T L E EK + + +LK + + E + + +K ++L++
Sbjct: 1009 KLLEERISDLTTNLAEEE----EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK 1064
Query: 634 SLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAH 693
L+GD S+ + DL+ + L KK+ + L+ AL + +E + + LKK
Sbjct: 1065 RKLEGDASDFHEQIADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQKNNALKKIR 1121
Query: 694 ---------------EAALEARASPEMSDRIQHLEREITRYKD--ESSKAQAEV----DR 732
E A +A + D + LE T +D +S+ Q E+ ++
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1181
Query: 733 LLEILK------------EVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSA 780
+ +LK +V+ + + + EL Q++ + ANL +Q +K++A
Sbjct: 1182 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1241
Query: 781 QMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESART 840
+ E R L + Q+++ +K + +++EL+ + + AE + + ++
Sbjct: 1242 DLAGELR----VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 841 NAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEK-------ETHLTNLRAER---RK 890
+ + E K+ +++ S+ ++L TQ+ L E+ T L L ER +
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1357
Query: 891 HLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQE---EVAALKREKDRLVQQLKQQ 947
L+E +E KQ E+ + ++LS SKKK Q+ V AL+ K R ++++
Sbjct: 1358 QLDEEMEAKQNL------ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 948 TQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCH 1007
TQ YE+ +T ++ ++ +++LD R + +L
Sbjct: 1412 TQ--------QYEEKAAAYDKLEKTKNR-LQQELDDLVVDLDNQRQ----LVSNLEKKQR 1458
Query: 1008 DRDPLILRGLTPPASYNLDDDQA---AWENELQKMTRGQLQDELEKGERDNAELQEFANA 1064
D L+ + Y + D+A A E E + ++ + +E + + + + A
Sbjct: 1459 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKA 1518
Query: 1065 ILQQIADHCPDILEQVVNALEES 1087
++ + D+ + V+ LE+S
Sbjct: 1519 EMEDLVSSKDDVGKN-VHELEKS 1540
Score = 110 bits (274), Expect = 9e-24
Identities = 140/708 (19%), Positives = 299/708 (42%), Gaps = 117/708 (16%)
Query: 142 SLRQARDNTIMDLQTQ-LKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL 200
+++ A+D + Q Q +E+L+E + +V K +L NS++ E++ ++ L
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
Query: 201 RKDEASKITIWKEQYRVVQEENQHMQMTIQALQD-ELRIQRDLNQLFQQDSSSRTGEPCV 259
+ I+ Q +++ Q T++AL++ + R Q+++ L QQ
Sbjct: 1370 ERH----ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ----------- 1414
Query: 260 AELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEML-QS 318
++ A +++ K L++ L+++ + ++ Q+Q ++ ++ +K ++L +
Sbjct: 1415 -------YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467
Query: 319 KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTK 378
K +S+K +E R AEAE +EKE L + +
Sbjct: 1468 KNISSKYADE-----RDRAEAEA-----------REKETKAL--------------SLAR 1497
Query: 379 ALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKN 438
AL+ +E K+ +ER + L+ E++ L S+ + E K + + MK
Sbjct: 1498 ALEEALEAKEE----LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 439 KIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDA 498
++ +++ EL + L L+ ++ L QF Q + E + QR
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR---------- 1603
Query: 499 LRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQ 558
+L E ET L + KQ A K G++ DL+ D + K++ LQ Q
Sbjct: 1604 ---QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660
Query: 559 LRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI---ERLKEQRDRDEREK 615
++D ++++ + + A + +LE L + + + ER ++Q D ++ E
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 675
EE+ + L+++ L+ +++ E L + + + +++ K + + L L
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 676 EQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREI-TRYKDESSKAQAEVDRLL 734
++ K ES ++ R + E+ ++ +E + +++K + +A++ +L
Sbjct: 1781 ATERSTAQKNESARQQLE------RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1834
Query: 735 EILKEVENEKN-------DKDKKIAELERQVKDQNKKVANLKHKEQVEK----------- 776
E +++ EK KDKK+ E+ QV+D+ K ++KEQ EK
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE--QYKEQAEKGNARVKQLKRQ 1892
Query: 777 ---------------KKSAQMLEEARRREDNLNDSSQQLQDSLRKKDD 809
+K + L+EA + + L+ LR+ ++
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 90.1 bits (222), Expect = 1e-17
Identities = 141/675 (20%), Positives = 271/675 (40%), Gaps = 104/675 (15%)
Query: 139 VPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSP--ELKK 196
V LRQ + LQ QL E + L + + +LS S ++ F S L++
Sbjct: 1341 VSTKLRQLEEER-NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Query: 197 ERALRKDEASKITIWKEQ----YRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSS 252
+ + E +T E+ Y +++ +Q + L +L QR L + +
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL--VSNLEKKQ 1457
Query: 253 RTGEPCVAELTEENFQRLHAEH---------ERQAKELFLLRKTLEEMELRIETQKQT-- 301
R + +AE E+N +A+ E++ K L L R E +E + E ++
Sbjct: 1458 RKFDQLLAE--EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515
Query: 302 --------LNARDESIKKLLEMLQSK-GLSAKATE--------EDHERTRRLAEAEMHVH 344
++++D+ K + E+ +SK L + E ED + A+ + V+
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575
Query: 345 ----------HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMK------- 387
L++ EQ E++ L+ ++H D K +AL + K
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 388 -----DSKISSMERGLRDLEE-EIQMLKSNGAL--STEEREEEMKQMEVYRSHSKFMKNK 439
DS I E ++ L + + QM L + R+E + +K ++
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695
Query: 440 IGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDAL 499
+ Q++++L+ + + E L + + S L++ E R A L+ E++
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755
Query: 500 RLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQL 559
+ +E + K T+Q + ++ E T+ +K ++++E ++L
Sbjct: 1756 QGNMEAMSDRVRKATQQAEQLSNELATERS-----------TAQKNESARQQLERQNKEL 1804
Query: 560 RDKEKQM-SSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEE 618
R K +M ++K + KS +A E I +L+EQ +++ REKQ
Sbjct: 1805 RSKLHEMEGAVKSKFKS-----------------TIAALEAKIAQLEEQVEQEAREKQAA 1847
Query: 619 IDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQK 678
+ K+ KD K K LLQ + K A KE A K ++R+K L+ LE+
Sbjct: 1848 TKSLKQ--KDKKLKEILLQVEDERKMAE--QYKEQAE-------KGNARVKQLKRQLEEA 1896
Query: 679 KEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILK 738
+EE ++ + +K EA S E R + + R +E+S + +++
Sbjct: 1897 EEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1956
Query: 739 EVENEKNDKDKKIAE 753
+ + + D + A+
Sbjct: 1957 NADGSEEETDTRDAD 1971
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 149 bits (375), Expect = 2e-35
Identities = 195/896 (21%), Positives = 385/896 (42%), Gaps = 122/896 (13%)
Query: 154 LQTQLK---EVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL---RKDEASK 207
LQ QL+ E+ E + +R + K+ +L ++ ++ E + + L RK A +
Sbjct: 899 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958
Query: 208 ITIWKEQYRVVQEENQHMQMT-------IQALQDELRIQRDLN-------QLFQQDSSSR 253
+ +EQ + Q +Q+ I+ L+DE+ + D N +L ++ S
Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
Query: 254 TGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 313
T E +N +L +HE EL + K E+ +E K+ L + +
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 314 EMLQS-----KGLSAKATEE--------------DHERTRRLAEAEMHVHHLESLLEQK- 353
LQ+ K AK EE + +++ E E H+ L+ L+ +
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 354 ------EKENSMLREEMHRRFENAPDSAKTKALQTVIEMK-DSKISSMERGL----RDLE 402
EK+ L EE+ D+ + A Q + K + +++ +++ L R E
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Query: 403 EEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNK----------------IGQVKQE 446
++Q ++ A + EE E+++Q + R+ + KNK +GQ KQE
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFK--RAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256
Query: 447 LSRKDTELLALQTKLET-----------LTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 495
+ K +L A +L++ L ++ + +E + L E +A L +
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 496 VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL 555
V +L +L++ + +L ++T+Q +++ + E + L+D LD + L++ I L
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 556 QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREK 615
QL D +K++ V++L+ + L + EK ++L++ ++R
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR----L 1432
Query: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 675
Q+E+D+ DL + ++ VS L+ + + L + K +S A D R + E
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA------DERDRA-EAEA 1485
Query: 676 EQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLERE-ITRYKDESSKAQAEVDRLL 734
+K+ + L L +A E ALEA+ E ++++ E E + KD+ K V L
Sbjct: 1486 REKETKAL----SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK---NVHELE 1538
Query: 735 EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 794
+ + +E + + ++ ELE +++ L+ Q K Q + + R++
Sbjct: 1539 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK---GQFERDLQARDEQNE 1595
Query: 795 DSSQQLQDSLRKKDDRIEE--LEEALRESVQITAEREM--VLAQEESA---RTNAEKQVE 847
+ +QLQ L + + +E+ + AL + + E ++ + Q +SA R A KQ+
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655
Query: 848 ELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAI 907
+L M+ ++ELE +A + E E +L A ++++++++ A
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-------DLMQLQEDLAAAER 1708
Query: 908 SEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ------QTQNRMKLMAD 957
+ K A++ EL+ + AL+ EK RL ++ Q + Q M+ M+D
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Score = 144 bits (364), Expect = 3e-34
Identities = 211/936 (22%), Positives = 398/936 (42%), Gaps = 150/936 (16%)
Query: 229 IQALQDEL-----RIQRDLNQL--FQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKEL 281
+QA +DEL R Q+ N+L +Q S T E + + + L+AE
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE-------- 912
Query: 282 FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRL-AEAE 340
EEM +R+ +KQ L +++L ++++ EE+ +R ++L AE +
Sbjct: 913 ------AEEMRVRLAAKKQEL-------EEILHEMEAR------LEEEEDRGQQLQAERK 953
Query: 341 MHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD 400
+ L EQ E+E + R+++ + E AK K L+ I + D + + + + +
Sbjct: 954 KMAQQMLDLEEQLEEEEA-ARQKL--QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1010
Query: 401 LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKN-KIGQVKQELSRKDTELL--AL 457
LEE I L +N A EE E+ ++ H + ++ K+E SR++ E L L
Sbjct: 1011 LEERISDLTTNLA---EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 458 QTKLETLTNQFSDSKQHIEVLKESLTAKEQ--RAAI-------------------LQTEV 496
+ Q +D + I LK L KE+ +AA+ L+ +
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 497 DALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKD-------MLDVKERKVNVLQ 549
L+ L+ + NK KQ +D+ EE E+ D D + +E++V VL+
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 550 KKIE--------NLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE--------- 592
K ++ +QE + + + L E+++ + N D TLE+
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247
Query: 593 -ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQ-------GDLSEKE 644
L + ++ +E K++ + +E Q + + ++ +L +KV LQ G L+E E
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 645 ASLLDLKEHASSLAS------SGLKKDSRLK-TLEIALEQKKEECLKMESQLKKAHEAA- 696
+ L + +SL+S L++++R K + L Q +EE ++ QL + EA
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 697 -LEARASP---EMSD---RIQHLEREITRYKDESSKAQAEVDRLLEILKE-------VEN 742
LE S ++SD ++Q + ++ + Q E++ L + +E +E
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 743 EKNDKDKKIAELERQVKDQNKKVANLKHKEQ-------VEKKKSAQMLEEARRREDNLND 795
KN +++ +L + +Q + V+NL+ K++ EK S++ +E R E +
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 796 SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA---EKQVEELLMA 852
+ R ++ +E EE R + + AE E +++ ++ N EK L
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 853 MEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHL---EEVLEMKQEALLAAISE 909
ME++K +LE ++ +L +T+ + E ++ L+ + + L +E E K+ L + E
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 910 -----KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHF 964
+D +++KKK + ++ L+ + D ++ ++ + KL A
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA------QM 1661
Query: 965 KSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYN 1024
K + + S D+I E N K K L L D + +
Sbjct: 1662 KDFQRELEDARASRDEIFATAKE---NEKKAKSLEADLMQLQED----LAAAERARKQAD 1714
Query: 1025 LDDDQAAWENELQKMTRGQLQDELEKGERDNAELQE 1060
L+ ++ A E R LQDE + E A+L+E
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750
Score = 130 bits (328), Expect = 5e-30
Identities = 189/869 (21%), Positives = 374/869 (43%), Gaps = 152/869 (17%)
Query: 151 IMDLQTQLKEVLRENDLLRKDVEVK------ESKLSSSMNSIKTFWSPE---------LK 195
I DLQ Q+ E+ + L +K+ E++ + +++ N++K E L
Sbjct: 1078 IADLQAQIAELKMQ--LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 196 KERALR-KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQ---DSS 251
ERA R K E K + +E + E + T A Q ELR +R+ + D
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEVTVLKKALDEE 1193
Query: 252 SRTGEPCVAELTEENFQRLHA------EHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
+R+ E V E+ +++ Q + + +R L ++TLE+ + + + L
Sbjct: 1194 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 306 DESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
+ ++ + L+++ ++ D ER R AE VH L++ + E ML E
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQN---EVESVTGMLNEAEG 1308
Query: 366 RRFENAPD----SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE 421
+ + A D S++ + Q +++ + + ++ LR LEEE L+ ++ +E
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ-------DQLDE 1361
Query: 422 EMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLAL-------QTKLETLTNQFSDSKQH 474
EM+ + H + ++ K++L + + AL Q ++E LT Q+ +
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 475 IEVLKESLTAKEQRAAILQTEVDALRL---RLEEK----------ETMLNKKTKQIQDMA 521
+ L+++ +Q L ++D R LE+K E ++ K +D A
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481
Query: 522 E----EKGTQAGEI-HDLKDMLDVKE---RKVNVLQ--------------KKIENLQEQL 559
E EK T+A + L++ L+ KE R +L+ K + L++
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541
Query: 560 RDKEKQMSSLKERVKSLQADTTNTDTALTTLE---EAL-AEKERTIERLKEQRDRDEREK 615
R E QM +K +++ L+ + T+ A LE +AL + ER ++ EQ + R+
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601
Query: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 675
Q ++ Y+ +L+D +++ +L + E L DL+ L+ DS +K E A+
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE----------LQADSAIKGREEAI 1651
Query: 676 EQKKEECLKMESQLKKAHEAALEARAS--------PEMSDRIQHLEREITRYKDE---SS 724
+Q + K+++Q+K +ARAS E + + LE ++ + +++ +
Sbjct: 1652 KQLR----KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 725 KAQAEVDRLLEILKE-----------VENEKNDKDKKIAELERQVKDQNKKVANLKHK-- 771
+A+ + D E L E +++EK + +IA+LE +++++ + + +
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 772 -----------EQVEKKKSAQMLEEAR----RREDNLNDSSQQLQDSLRKK--------D 808
E ++ +AQ E AR R+ L +++ +++ K +
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1827
Query: 809 DRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLS 868
+I +LEE + + + L Q++ QVE+ E+ K++ E A++
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1887
Query: 869 STQQSLAEKETHLTNLRAERRKHLEEVLE 897
++ L E E + A RRK E+ E
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDE 1916
Score = 119 bits (298), Expect = 2e-26
Identities = 182/806 (22%), Positives = 357/806 (44%), Gaps = 112/806 (13%)
Query: 136 ASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESK----LSSSMNSIKTFWS 191
++ LR R+ + L+ L E R ++ +++ K ++ L+ + K +
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227
Query: 192 PELKKERALRK---DEASKITIWKEQYRVVQEENQHMQMTIQALQ----DELRIQRDLNQ 244
K ++ L K D A ++ + + + V+ + + ++ +Q LQ D R + +LN
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 245 L---FQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQT 301
Q + S TG AE + A Q ++ L + +L + T+ +
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 302 LNARDESIKKLLEMLQSKGLSAKATEEDHERTR--RLAEAEMHVHHLESLLE-------- 351
L S++ L+ + + AK E H T +L++++ + S +E
Sbjct: 1348 LEEERNSLQDQLD----EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403
Query: 352 -QKEKENSMLREE----MHRRFENAPDSAKTKALQTVIEMKDSK--ISSMERGLRDLEEE 404
QKE EN + E + + E + + + V+++ + + +S++E+ R ++
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463
Query: 405 IQMLKSNGALSTEER--------EEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLA 456
+ K+ + +ER E+E K + + R+ + + + K+EL R + L A
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-----EAKEELERTNKMLKA 1518
Query: 457 LQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQ 516
++E L + D +++ L++S A E + ++T+++ L L+ E + K +
Sbjct: 1519 ---EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE---DAKLRL 1572
Query: 517 IQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSL 576
+M KG DL+ + E K LQ+++ + +L D+ KQ + K L
Sbjct: 1573 EVNMQALKGQFE---RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Query: 577 QADTTN----TDTALTTLEEALAEKERTIERLKE-QRD-RDEREKQEEI-----DNYKKD 625
+ D + D+A+ EEA+ + + ++K+ QR+ D R ++EI +N KK
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK- 1688
Query: 626 LKDLKEKVSLLQGDLS--EKEASLLDLK------EHASSLASSGLKKDSRLKTLEIALEQ 677
K L+ + LQ DL+ E+ DL+ E ASSL+ +D + + LE + Q
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK-RRLEARIAQ 1747
Query: 678 KKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDR--LLE 735
+EE + + ++ + +A E ER T K+ES++ Q E L
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS-TAQKNESARQQLERQNKELRS 1806
Query: 736 ILKEVENEKNDKDK--------KIAELERQVKDQ-NKKVANLKHKEQVEKKKSAQMLEEA 786
L E+E K K KIA+LE QV+ + +K A K +Q +KK L+E
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK-----LKEI 1861
Query: 787 RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA---- 842
+ ++ ++Q ++ K + R+++L+ L E A+EES R NA
Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE------------AEEESQRINANRRK 1909
Query: 843 -EKQVEELLMAMEKVKQELESMKAKL 867
+++++E + E + +E+ ++K+KL
Sbjct: 1910 LQRELDEATESNEAMGREVNALKSKL 1935
Score = 115 bits (289), Expect = 2e-25
Identities = 169/803 (21%), Positives = 349/803 (43%), Gaps = 106/803 (13%)
Query: 345 HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE 404
HLE + K + M + M R + AK + T +++ ++ + LR+ +
Sbjct: 784 HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK-LRNWQWW 842
Query: 405 IQMLKSNGALSTEEREEEM--KQMEVYRSHSKFMK--NKIGQVKQELSRKDTELLALQTK 460
K L +EEEM K+ E+ ++ + K N++ +++Q+ S+ E LQ +
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 461 LETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDM 520
L+ T ++++++ ++ L AK+Q + E++A RLEE+E + Q +
Sbjct: 903 LQAETELYAEAEE----MRVRLAAKKQELEEILHEMEA---RLEEEED-------RGQQL 948
Query: 521 AEEKGTQAGEIHDLKDMLDVKERKVNVLQ-------KKIENLQEQLRDKEKQMSSLKERV 573
E+ A ++ DL++ L+ +E LQ KI+ L++++ + Q + L +
Sbjct: 949 QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008
Query: 574 KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV 633
K L+ ++ T L E EK + + +LK + + E + + +K ++L++
Sbjct: 1009 KLLEERISDLTTNLAEEE----EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK 1064
Query: 634 SLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAH 693
L+GD S+ + DL+ + L KK+ + L+ AL + +E + + LKK
Sbjct: 1065 RKLEGDASDFHEQIADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQKNNALKKIR 1121
Query: 694 ---------------EAALEARASPEMSDRIQHLEREITRYKD--ESSKAQAEV----DR 732
E A +A + D + LE T +D +S+ Q E+ ++
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1181
Query: 733 LLEILK------------EVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSA 780
+ +LK +V+ + + + EL Q++ + ANL +Q +K++A
Sbjct: 1182 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1241
Query: 781 QMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESART 840
+ E R L + Q+++ +K + +++EL+ + + AE + + ++
Sbjct: 1242 DLAGELR----VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 841 NAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEK-------ETHLTNLRAER---RK 890
+ + E K+ +++ S+ ++L TQ+ L E+ T L L ER +
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1357
Query: 891 HLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQE---EVAALKREKDRLVQQLKQQ 947
L+E +E KQ E+ + ++LS SKKK Q+ V AL+ K R ++++
Sbjct: 1358 QLDEEMEAKQNL------ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 948 TQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCH 1007
TQ YE+ +T ++ ++ +++LD R + +L
Sbjct: 1412 TQ--------QYEEKAAAYDKLEKTKNR-LQQELDDLVVDLDNQRQ----LVSNLEKKQR 1458
Query: 1008 DRDPLILRGLTPPASYNLDDDQA---AWENELQKMTRGQLQDELEKGERDNAELQEFANA 1064
D L+ + Y + D+A A E E + ++ + +E + + + + A
Sbjct: 1459 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKA 1518
Query: 1065 ILQQIADHCPDILEQVVNALEES 1087
++ + D+ + V+ LE+S
Sbjct: 1519 EMEDLVSSKDDVGKN-VHELEKS 1540
Score = 78.2 bits (191), Expect = 4e-14
Identities = 104/522 (19%), Positives = 210/522 (40%), Gaps = 42/522 (8%)
Query: 143 LRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRK 202
L+Q D+ ++DL Q + V L K + L+ N + + E R+
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSN----LEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 203 DEASKITIWK--EQYRVVQEENQHMQMTIQALQDELRIQRDL--NQLFQQDSSSRTGEPC 258
E +++ + E+ +EE + ++A ++L +D + + + S R E
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE-- 1545
Query: 259 VAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQS 318
++ E Q E E QA E LR + L+ + ++ L ARDE ++ LQ
Sbjct: 1546 -TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD-LQARDEQNEEKRRQLQR 1603
Query: 319 KGLSAKATEEDHERTRRLAEA-----EMHVHHLE----SLLEQKEKENSMLRE------E 363
+ + ED + R LA A E + LE S ++ +E+ LR+ +
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 364 MHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEI---QMLKSNGALSTEERE 420
R E+A A + + + K S+E L L+E++ + + L EE
Sbjct: 1664 FQRELEDA--RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 421 EEMKQM----EVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIE 476
EE+ + + ++ +I Q+++EL + + A+ ++ T Q +
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 477 VLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKD 536
+ + E L+ + LR +L E E + K K E K I L++
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK------IAQLEE 1835
Query: 537 MLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAE 596
++ + R+ K ++ ++L++ Q+ ++ + + + + L+ L E
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 597 KERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQG 638
E +R+ R + +RE E ++ + +++ S L+G
Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1937
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 149 bits (375), Expect = 2e-35
Identities = 195/896 (21%), Positives = 385/896 (42%), Gaps = 122/896 (13%)
Query: 154 LQTQLK---EVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL---RKDEASK 207
LQ QL+ E+ E + +R + K+ +L ++ ++ E + + L RK A +
Sbjct: 892 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951
Query: 208 ITIWKEQYRVVQEENQHMQMT-------IQALQDELRIQRDLN-------QLFQQDSSSR 253
+ +EQ + Q +Q+ I+ L+DE+ + D N +L ++ S
Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011
Query: 254 TGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 313
T E +N +L +HE EL + K E+ +E K+ L + +
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 314 EMLQS-----KGLSAKATEE--------------DHERTRRLAEAEMHVHHLESLLEQK- 353
LQ+ K AK EE + +++ E E H+ L+ L+ +
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 354 ------EKENSMLREEMHRRFENAPDSAKTKALQTVIEMK-DSKISSMERGL----RDLE 402
EK+ L EE+ D+ + A Q + K + +++ +++ L R E
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Query: 403 EEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNK----------------IGQVKQE 446
++Q ++ A + EE E+++Q + R+ + KNK +GQ KQE
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFK--RAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249
Query: 447 LSRKDTELLALQTKLET-----------LTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 495
+ K +L A +L++ L ++ + +E + L E +A L +
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 496 VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL 555
V +L +L++ + +L ++T+Q +++ + E + L+D LD + L++ I L
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 556 QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREK 615
QL D +K++ V++L+ + L + EK ++L++ ++R
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR----L 1425
Query: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 675
Q+E+D+ DL + ++ VS L+ + + L + K +S A D R + E
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA------DERDRA-EAEA 1478
Query: 676 EQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLERE-ITRYKDESSKAQAEVDRLL 734
+K+ + L L +A E ALEA+ E ++++ E E + KD+ K V L
Sbjct: 1479 REKETKAL----SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK---NVHELE 1531
Query: 735 EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 794
+ + +E + + ++ ELE +++ L+ Q K Q + + R++
Sbjct: 1532 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK---GQFERDLQARDEQNE 1588
Query: 795 DSSQQLQDSLRKKDDRIEE--LEEALRESVQITAEREM--VLAQEESA---RTNAEKQVE 847
+ +QLQ L + + +E+ + AL + + E ++ + Q +SA R A KQ+
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648
Query: 848 ELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAI 907
+L M+ ++ELE +A + E E +L A ++++++++ A
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-------DLMQLQEDLAAAER 1701
Query: 908 SEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ------QTQNRMKLMAD 957
+ K A++ EL+ + AL+ EK RL ++ Q + Q M+ M+D
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Score = 144 bits (364), Expect = 3e-34
Identities = 211/936 (22%), Positives = 398/936 (42%), Gaps = 150/936 (16%)
Query: 229 IQALQDEL-----RIQRDLNQL--FQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKEL 281
+QA +DEL R Q+ N+L +Q S T E + + + L+AE
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE-------- 905
Query: 282 FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRL-AEAE 340
EEM +R+ +KQ L +++L ++++ EE+ +R ++L AE +
Sbjct: 906 ------AEEMRVRLAAKKQEL-------EEILHEMEAR------LEEEEDRGQQLQAERK 946
Query: 341 MHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD 400
+ L EQ E+E + R+++ + E AK K L+ I + D + + + + +
Sbjct: 947 KMAQQMLDLEEQLEEEEA-ARQKL--QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1003
Query: 401 LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKN-KIGQVKQELSRKDTELL--AL 457
LEE I L +N A EE E+ ++ H + ++ K+E SR++ E L L
Sbjct: 1004 LEERISDLTTNLA---EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 458 QTKLETLTNQFSDSKQHIEVLKESLTAKEQ--RAAI-------------------LQTEV 496
+ Q +D + I LK L KE+ +AA+ L+ +
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 497 DALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKD-------MLDVKERKVNVLQ 549
L+ L+ + NK KQ +D+ EE E+ D D + +E++V VL+
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 550 KKIE--------NLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE--------- 592
K ++ +QE + + + L E+++ + N D TLE+
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240
Query: 593 -ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQ-------GDLSEKE 644
L + ++ +E K++ + +E Q + + ++ +L +KV LQ G L+E E
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 645 ASLLDLKEHASSLAS------SGLKKDSRLK-TLEIALEQKKEECLKMESQLKKAHEAA- 696
+ L + +SL+S L++++R K + L Q +EE ++ QL + EA
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Query: 697 -LEARASP---EMSD---RIQHLEREITRYKDESSKAQAEVDRLLEILKE-------VEN 742
LE S ++SD ++Q + ++ + Q E++ L + +E +E
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 743 EKNDKDKKIAELERQVKDQNKKVANLKHKEQ-------VEKKKSAQMLEEARRREDNLND 795
KN +++ +L + +Q + V+NL+ K++ EK S++ +E R E +
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 796 SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA---EKQVEELLMA 852
+ R ++ +E EE R + + AE E +++ ++ N EK L
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 853 MEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHL---EEVLEMKQEALLAAISE 909
ME++K +LE ++ +L +T+ + E ++ L+ + + L +E E K+ L + E
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 910 -----KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHF 964
+D +++KKK + ++ L+ + D ++ ++ + KL A
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA------QM 1654
Query: 965 KSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYN 1024
K + + S D+I E N K K L L D + +
Sbjct: 1655 KDFQRELEDARASRDEIFATAKE---NEKKAKSLEADLMQLQED----LAAAERARKQAD 1707
Query: 1025 LDDDQAAWENELQKMTRGQLQDELEKGERDNAELQE 1060
L+ ++ A E R LQDE + E A+L+E
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743
Score = 130 bits (328), Expect = 5e-30
Identities = 189/869 (21%), Positives = 374/869 (43%), Gaps = 152/869 (17%)
Query: 151 IMDLQTQLKEVLRENDLLRKDVEVK------ESKLSSSMNSIKTFWSPE---------LK 195
I DLQ Q+ E+ + L +K+ E++ + +++ N++K E L
Sbjct: 1071 IADLQAQIAELKMQ--LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 196 KERALR-KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQ---DSS 251
ERA R K E K + +E + E + T A Q ELR +R+ + D
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEVTVLKKALDEE 1186
Query: 252 SRTGEPCVAELTEENFQRLHA------EHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
+R+ E V E+ +++ Q + + +R L ++TLE+ + + + L
Sbjct: 1187 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 306 DESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
+ ++ + L+++ ++ D ER R AE VH L++ + E ML E
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQN---EVESVTGMLNEAEG 1301
Query: 366 RRFENAPD----SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE 421
+ + A D S++ + Q +++ + + ++ LR LEEE L+ ++ +E
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ-------DQLDE 1354
Query: 422 EMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLAL-------QTKLETLTNQFSDSKQH 474
EM+ + H + ++ K++L + + AL Q ++E LT Q+ +
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 475 IEVLKESLTAKEQRAAILQTEVDALRL---RLEEK----------ETMLNKKTKQIQDMA 521
+ L+++ +Q L ++D R LE+K E ++ K +D A
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474
Query: 522 E----EKGTQAGEI-HDLKDMLDVKE---RKVNVLQ--------------KKIENLQEQL 559
E EK T+A + L++ L+ KE R +L+ K + L++
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534
Query: 560 RDKEKQMSSLKERVKSLQADTTNTDTALTTLE---EAL-AEKERTIERLKEQRDRDEREK 615
R E QM +K +++ L+ + T+ A LE +AL + ER ++ EQ + R+
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594
Query: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 675
Q ++ Y+ +L+D +++ +L + E L DL+ L+ DS +K E A+
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE----------LQADSAIKGREEAI 1644
Query: 676 EQKKEECLKMESQLKKAHEAALEARAS--------PEMSDRIQHLEREITRYKDE---SS 724
+Q + K+++Q+K +ARAS E + + LE ++ + +++ +
Sbjct: 1645 KQLR----KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 725 KAQAEVDRLLEILKE-----------VENEKNDKDKKIAELERQVKDQNKKVANLKHK-- 771
+A+ + D E L E +++EK + +IA+LE +++++ + + +
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 772 -----------EQVEKKKSAQMLEEAR----RREDNLNDSSQQLQDSLRKK--------D 808
E ++ +AQ E AR R+ L +++ +++ K +
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1820
Query: 809 DRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLS 868
+I +LEE + + + L Q++ QVE+ E+ K++ E A++
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1880
Query: 869 STQQSLAEKETHLTNLRAERRKHLEEVLE 897
++ L E E + A RRK E+ E
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDE 1909
Score = 119 bits (298), Expect = 2e-26
Identities = 182/806 (22%), Positives = 357/806 (44%), Gaps = 112/806 (13%)
Query: 136 ASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESK----LSSSMNSIKTFWS 191
++ LR R+ + L+ L E R ++ +++ K ++ L+ + K +
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Query: 192 PELKKERALRK---DEASKITIWKEQYRVVQEENQHMQMTIQALQ----DELRIQRDLNQ 244
K ++ L K D A ++ + + + V+ + + ++ +Q LQ D R + +LN
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 245 L---FQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQT 301
Q + S TG AE + A Q ++ L + +L + T+ +
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 302 LNARDESIKKLLEMLQSKGLSAKATEEDHERTR--RLAEAEMHVHHLESLLE-------- 351
L S++ L+ + + AK E H T +L++++ + S +E
Sbjct: 1341 LEEERNSLQDQLD----EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396
Query: 352 -QKEKENSMLREE----MHRRFENAPDSAKTKALQTVIEMKDSK--ISSMERGLRDLEEE 404
QKE EN + E + + E + + + V+++ + + +S++E+ R ++
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456
Query: 405 IQMLKSNGALSTEER--------EEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLA 456
+ K+ + +ER E+E K + + R+ + + + K+EL R + L A
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-----EAKEELERTNKMLKA 1511
Query: 457 LQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQ 516
++E L + D +++ L++S A E + ++T+++ L L+ E + K +
Sbjct: 1512 ---EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE---DAKLRL 1565
Query: 517 IQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSL 576
+M KG DL+ + E K LQ+++ + +L D+ KQ + K L
Sbjct: 1566 EVNMQALKGQFE---RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Query: 577 QADTTN----TDTALTTLEEALAEKERTIERLKE-QRD-RDEREKQEEI-----DNYKKD 625
+ D + D+A+ EEA+ + + ++K+ QR+ D R ++EI +N KK
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK- 1681
Query: 626 LKDLKEKVSLLQGDLS--EKEASLLDLK------EHASSLASSGLKKDSRLKTLEIALEQ 677
K L+ + LQ DL+ E+ DL+ E ASSL+ +D + + LE + Q
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK-RRLEARIAQ 1740
Query: 678 KKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDR--LLE 735
+EE + + ++ + +A E ER T K+ES++ Q E L
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS-TAQKNESARQQLERQNKELRS 1799
Query: 736 ILKEVENEKNDKDK--------KIAELERQVKDQ-NKKVANLKHKEQVEKKKSAQMLEEA 786
L E+E K K KIA+LE QV+ + +K A K +Q +KK L+E
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK-----LKEI 1854
Query: 787 RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA---- 842
+ ++ ++Q ++ K + R+++L+ L E A+EES R NA
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE------------AEEESQRINANRRK 1902
Query: 843 -EKQVEELLMAMEKVKQELESMKAKL 867
+++++E + E + +E+ ++K+KL
Sbjct: 1903 LQRELDEATESNEAMGREVNALKSKL 1928
Score = 115 bits (289), Expect = 2e-25
Identities = 169/803 (21%), Positives = 349/803 (43%), Gaps = 106/803 (13%)
Query: 345 HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE 404
HLE + K + M + M R + AK + T +++ ++ + LR+ +
Sbjct: 777 HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK-LRNWQWW 835
Query: 405 IQMLKSNGALSTEEREEEM--KQMEVYRSHSKFMK--NKIGQVKQELSRKDTELLALQTK 460
K L +EEEM K+ E+ ++ + K N++ +++Q+ S+ E LQ +
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 461 LETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDM 520
L+ T ++++++ ++ L AK+Q + E++A RLEE+E + Q +
Sbjct: 896 LQAETELYAEAEE----MRVRLAAKKQELEEILHEMEA---RLEEEED-------RGQQL 941
Query: 521 AEEKGTQAGEIHDLKDMLDVKERKVNVLQ-------KKIENLQEQLRDKEKQMSSLKERV 573
E+ A ++ DL++ L+ +E LQ KI+ L++++ + Q + L +
Sbjct: 942 QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001
Query: 574 KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV 633
K L+ ++ T L E EK + + +LK + + E + + +K ++L++
Sbjct: 1002 KLLEERISDLTTNLAEEE----EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK 1057
Query: 634 SLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAH 693
L+GD S+ + DL+ + L KK+ + L+ AL + +E + + LKK
Sbjct: 1058 RKLEGDASDFHEQIADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQKNNALKKIR 1114
Query: 694 ---------------EAALEARASPEMSDRIQHLEREITRYKD--ESSKAQAEV----DR 732
E A +A + D + LE T +D +S+ Q E+ ++
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1174
Query: 733 LLEILK------------EVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSA 780
+ +LK +V+ + + + EL Q++ + ANL +Q +K++A
Sbjct: 1175 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1234
Query: 781 QMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESART 840
+ E R L + Q+++ +K + +++EL+ + + AE + + ++
Sbjct: 1235 DLAGELR----VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 841 NAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEK-------ETHLTNLRAER---RK 890
+ + E K+ +++ S+ ++L TQ+ L E+ T L L ER +
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1350
Query: 891 HLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQE---EVAALKREKDRLVQQLKQQ 947
L+E +E KQ E+ + ++LS SKKK Q+ V AL+ K R ++++
Sbjct: 1351 QLDEEMEAKQNL------ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 948 TQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCH 1007
TQ YE+ +T ++ ++ +++LD R + +L
Sbjct: 1405 TQ--------QYEEKAAAYDKLEKTKNR-LQQELDDLVVDLDNQRQ----LVSNLEKKQR 1451
Query: 1008 DRDPLILRGLTPPASYNLDDDQA---AWENELQKMTRGQLQDELEKGERDNAELQEFANA 1064
D L+ + Y + D+A A E E + ++ + +E + + + + A
Sbjct: 1452 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKA 1511
Query: 1065 ILQQIADHCPDILEQVVNALEES 1087
++ + D+ + V+ LE+S
Sbjct: 1512 EMEDLVSSKDDVGKN-VHELEKS 1533
Score = 78.2 bits (191), Expect = 4e-14
Identities = 104/522 (19%), Positives = 210/522 (40%), Gaps = 42/522 (8%)
Query: 143 LRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRK 202
L+Q D+ ++DL Q + V L K + L+ N + + E R+
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSN----LEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 203 DEASKITIWK--EQYRVVQEENQHMQMTIQALQDELRIQRDL--NQLFQQDSSSRTGEPC 258
E +++ + E+ +EE + ++A ++L +D + + + S R E
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE-- 1538
Query: 259 VAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQS 318
++ E Q E E QA E LR + L+ + ++ L ARDE ++ LQ
Sbjct: 1539 -TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD-LQARDEQNEEKRRQLQR 1596
Query: 319 KGLSAKATEEDHERTRRLAEA-----EMHVHHLE----SLLEQKEKENSMLRE------E 363
+ + ED + R LA A E + LE S ++ +E+ LR+ +
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656
Query: 364 MHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEI---QMLKSNGALSTEERE 420
R E+A A + + + K S+E L L+E++ + + L EE
Sbjct: 1657 FQRELEDA--RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 421 EEMKQM----EVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIE 476
EE+ + + ++ +I Q+++EL + + A+ ++ T Q +
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 477 VLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKD 536
+ + E L+ + LR +L E E + K K E K I L++
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK------IAQLEE 1828
Query: 537 MLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAE 596
++ + R+ K ++ ++L++ Q+ ++ + + + + L+ L E
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 597 KERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQG 638
E +R+ R + +RE E ++ + +++ S L+G
Sbjct: 1889 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1930
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 149 bits (375), Expect = 2e-35
Identities = 186/837 (22%), Positives = 362/837 (43%), Gaps = 76/837 (9%)
Query: 142 SLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALR 201
+L++A T+ DLQ + +V N L + +++ E ++ S++ + ERA R
Sbjct: 1004 ALQEAHQQTLDDLQAEEDKV---NTLTKAKIKL-EQQVDDLEGSLEQEKKLRMDLERAKR 1059
Query: 202 KDEASKITIWKEQYRVVQEENQHM-------QMTIQALQDELRIQRDLNQLFQQDSSSRT 254
K E + + +E ++ E Q + + I LQ ++ ++ L Q +
Sbjct: 1060 KLEGD-LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG--IQLQKKIKE 1116
Query: 255 GEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLE 314
+ + EL EE + A + K+ L + LEE+ R+E +A+ E KK
Sbjct: 1117 LQARIEEL-EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1175
Query: 315 MLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDS 374
Q + HE T A + H +S+ E E+ +++ R + E +
Sbjct: 1176 EFQKMRRDLEEATLQHEATA----ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK 1231
Query: 375 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
+ L + +E ++E+ R LE+++ LKS EE++ + + R
Sbjct: 1232 MEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK----EEEQQRLINDLTAQRGR-- 1285
Query: 435 FMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQT 494
++ + G+ ++L K+ + L + T Q + K+ +E E + AK A LQ+
Sbjct: 1286 -LQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLE---EEIKAKNALAHALQS 1341
Query: 495 ---EVDALRLRLEEKETM-------LNKKTKQIQDMAEEKGTQAGE-IHDLKDMLDVKER 543
+ D LR + EE++ L+K ++ + T A + +L++ +
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1401
Query: 544 KVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIER 603
++ ++ +E + + EK L+ V+ L D T+ A L++ K+R ++
Sbjct: 1402 RLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK----KQRNFDK 1457
Query: 604 LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK-------EHASS 656
+ + + E E++ +K+ + L ++ ++ E L LK + S
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 657 LASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREI 716
L + R+ LE +Q ++E ++++ L++A EA+LE +I ++ E+
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEA-EASLEHEEG-----KILRIQLEL 1571
Query: 717 TRYKDESSKAQAEVDRLLEILKE-----VENEKNDKDKKIAELERQVKDQNKKVANLKHK 771
+ K E + AE D ++ LK VE+ ++ D +I ++ + K +L
Sbjct: 1572 NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631
Query: 772 E---QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAER 828
E + +A+ L R + L D+ L D+LR ++D E+L R + + AE
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691
Query: 829 EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAER 888
E + A E + + +ELL A E+V Q L + L +T++ L ET ++ ++ E
Sbjct: 1692 EELRATLEQTERSRKIAEQELLDASERV-QLLHTQNTSLINTKKKL---ETDISQMQGE- 1746
Query: 889 RKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLK 945
+E++L QEA A K A ++ KK Q+ A L+R K + Q +K
Sbjct: 1747 ---MEDIL---QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797
Score = 127 bits (318), Expect = 7e-29
Identities = 197/929 (21%), Positives = 407/929 (43%), Gaps = 117/929 (12%)
Query: 191 SPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDS 250
S E +KE A K+E KI + ++E + +T+ +++L++Q D+
Sbjct: 848 SAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADA 907
Query: 251 SSRTG---------EPCVAELTE--ENFQRLHAEHERQAKEL----FLLRKTLEEMELRI 295
R E + E+TE E+ + ++AE + ++L L+K ++++EL +
Sbjct: 908 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 296 ETQKQTLNARDESIKKLLEMLQSKGLS---AKATEEDHERTRRLAEAEMHVHHLESLLEQ 352
++ +A + +K L E + GL AK T+E + A E H L+ L +
Sbjct: 968 AKVEKEKHATENKVKNLTE--EMAGLDETIAKLTKE------KKALQEAHQQTLDDLQAE 1019
Query: 353 KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNG 412
++K N++ + ++ + E D L+ +E + +ER R LE ++++ +
Sbjct: 1020 EDKVNTLTKAKI--KLEQQVDD-----LEGSLEQEKKLRMDLERAKRKLEGDLKLAQE-- 1070
Query: 413 ALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSK 472
S + E E +Q++ +F +I ++ ++ + + LQ K++ L + + +
Sbjct: 1071 --SIMDIENEKQQLDEKLKKKEF---EISNLQSKIEDEQALGIQLQKKIKELQARIEELE 1125
Query: 473 QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK------ETMLNKKTKQIQDMAEEKGT 526
+ IE + S E++ + L E++ + RLEE + +NKK +
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1185
Query: 527 QAGEIHDLKDMLDVKERKVNV--LQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 584
+A H+ K+ +V L ++I+NLQ + EK+ S +K + L ++
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVS 1245
Query: 585 TALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKE 644
A LE+ E + LK K+EE DL + ++ G+ S +
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKS--------KEEEQQRLINDLTAQRGRLQTESGEFSRQ- 1296
Query: 645 ASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA-----HEAALEA 699
LD KE S S G K + + +E L+++ EE +K ++ L A H+ L
Sbjct: 1297 ---LDEKEALVSQLSRG--KQAFTQQIE-ELKRQLEEEIKAKNALAHALQSSRHDCDLLR 1350
Query: 700 RASPEMSDRIQHLEREITRYKDESSKAQAEVDR-LLEILKEVENEKNDKDKKIAELERQV 758
E + L+R +++ E ++ + + + ++ +E+E K +++ E V
Sbjct: 1351 EQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHV 1410
Query: 759 KDQNKKVANL-KHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEA 817
+ N K A+L K K++++ + ML+ R N + L R D + E ++
Sbjct: 1411 EAVNAKCASLEKTKQRLQNEVEDLMLDVERT-----NAACAALDKKQRNFDKILAEWKQK 1465
Query: 818 LRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEK 877
E+ E+ +Q+E+ E + ++ A E+ +LE++K + + QQ +++
Sbjct: 1466 CEET-----HAELEASQKEARSLGTE--LFKIKNAYEESLDQLETLKRENKNLQQEISD- 1517
Query: 878 ETHLTNLRAERRKHLEEVLEMKQEA------LLAAISEKDANIA-----LLELSSSKKKT 926
LT AE K + E+ ++K++ L AA+ E +A++ +L + +
Sbjct: 1518 ---LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQV 1574
Query: 927 QEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLL 986
+ EV EKD + QLK +N ++++ +S S S + I+
Sbjct: 1575 KSEVDRKIAEKDEEIDQLK---RNHIRIV---------ESMQSTLDAEIRSRNDAIRLKK 1622
Query: 987 ELDQNRSKLKLYIGHLTTLCHD--RDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQ- 1043
+++ + +++++ + H + + R+ +G+ +LDD + E+ +++ +
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVER 1682
Query: 1044 ----LQDELEKGERDNAELQEFANAILQQ 1068
LQ E+E+ R E E + I +Q
Sbjct: 1683 RANLLQAEIEE-LRATLEQTERSRKIAEQ 1710
Score = 123 bits (309), Expect = 8e-28
Identities = 153/749 (20%), Positives = 328/749 (43%), Gaps = 129/749 (17%)
Query: 414 LSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ 473
L + E E+EM M K + ++K EL++ + + L+ K+ TL + +D +
Sbjct: 846 LKSAETEKEMATM----------KEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 474 HIEVLKESLTAKEQRA-------AILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 526
++ E L E+R L+ ++ + R E++E + + T + + + +E
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 527 QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 586
+I DL+ L E++ + + K++NL E++ ++ ++ L + K+LQ +
Sbjct: 956 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ------EAH 1009
Query: 587 LTTLEEALAEKER--TIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKE 644
TL++ AE+++ T+ + K + ++ + + ++ KK DL+ L+GDL +
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069
Query: 645 ASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAH----------- 693
S++D++ L KK+ + L+ +E ++ ++++ ++K+
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE 1129
Query: 694 -EAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 752
E A A+A + SD + LE R ++ A+++ + +E E +K +D + A
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE--MNKKREAEFQKMRRDLEEA 1187
Query: 753 ELERQ-------------VKDQNKKVANLKH-KEQVEKKKSAQMLE--EARRREDNLNDS 796
L+ + V + +++ NL+ K+++EK+KS +E + + ++ +
Sbjct: 1188 TLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKA 1247
Query: 797 SQQLQDSLRKKDDRIEEL----EEALRESVQITAEREMVLAQE-ESARTNAEKQ--VEEL 849
L+ R +D++ EL EE R +TA+R + + E +R EK+ V +L
Sbjct: 1248 KGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQL 1307
Query: 850 LMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAER------RKHLEEVLEMKQEAL 903
+ Q++E +K +L ++ + K L++ R R+ EE E K E L
Sbjct: 1308 SRGKQAFTQQIEELKRQL---EEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAE-L 1363
Query: 904 LAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDH 963
A+S+ + +A + +T+ E A++R ++ +++ K++ R++ ++ E +
Sbjct: 1364 QRALSKANTEVA-------QWRTKYETDAIQRTEE--LEEAKKKLAQRLQAAEEHVEAVN 1414
Query: 964 FKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASY 1023
K + +T + L L L + C D
Sbjct: 1415 AKCASLEKTKQR------------LQNEVEDLMLDVERTNAACAALD---------KKQR 1453
Query: 1024 NLDDDQAAWENELQKMTRGQLQ------------------------DELEKGERDNAELQ 1059
N D A W+ + ++ T +L+ D+LE +R+N LQ
Sbjct: 1454 NFDKILAEWKQKCEE-THAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQ 1512
Query: 1060 EFANAILQQIADHCPDI--LEQVVNALEE 1086
+ + + +QIA+ I LE++ +E+
Sbjct: 1513 QEISDLTEQIAEGGKRIHELEKIKKQVEQ 1541
Score = 101 bits (252), Expect = 3e-21
Identities = 159/728 (21%), Positives = 295/728 (40%), Gaps = 136/728 (18%)
Query: 309 IKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRF 368
IK LL+ +++ A EE + LA++E LE + KE + L+ ++
Sbjct: 842 IKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEA 901
Query: 369 ENAPDSAKT--KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQM 426
E D+ + + ++T I++ ++KI + D EEEI N L+ ++R+ E +
Sbjct: 902 EGLADAEERCDQLIKTKIQL-EAKIKEVTERAED-EEEI-----NAELTAKKRKLEDECS 954
Query: 427 EVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVL----KESL 482
E +K I ++ L++ + E A + K++ LT + + + I L K
Sbjct: 955 E--------LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1006
Query: 483 TAKEQRAAILQTEVDAL------RLRLEEK----ETMLNKKTKQIQDMAEEKGTQAGE-- 530
A +Q LQ E D + +++LE++ E L ++ K D+ K G+
Sbjct: 1007 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1066
Query: 531 --------IHDLKDMLDVK-------------------------ERKVNVLQKKIENLQE 557
I + K LD K ++K+ LQ +IE L+E
Sbjct: 1067 LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE 1126
Query: 558 QLRDK-------EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR 610
++ + EKQ S L ++ + A T + K+R E K +RD
Sbjct: 1127 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA--TSAQIEMNKKREAEFQKMRRDL 1184
Query: 611 DEREKQEEI------DNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKK 664
+E Q E + + +L E++ LQ + E ++K LAS+
Sbjct: 1185 EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN---- 1240
Query: 665 DSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR-IQHLEREITRYKDES 723
++T+ A ++ C +E QL E ++ E R I L + R + ES
Sbjct: 1241 ---VETVSKAKGNLEKMCRTLEDQLS-------ELKSKEEEQQRLINDLTAQRGRLQTES 1290
Query: 724 SKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQML 783
+ ++D ++ ++ K ++I EL+RQ++++ K L H Q + +L
Sbjct: 1291 GEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQ-SSRHDCDLL 1349
Query: 784 EEARRREDNLNDSSQQLQDSLRKKD---------------DRIEELEEALRESVQ-ITAE 827
E E +S +LQ +L K + R EELEEA ++ Q + A
Sbjct: 1350 REQYEEE---QESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA 1406
Query: 828 REMV------LAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHL 881
E V A E + + +VE+L++ +E+ ++ K + + LAE +
Sbjct: 1407 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKC 1466
Query: 882 TNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLV 941
AE +E + E L ++ ++ +++ +++ LKRE L
Sbjct: 1467 EETHAELEASQKEARSLGTE--------------LFKIKNAYEESLDQLETLKRENKNLQ 1512
Query: 942 QQLKQQTQ 949
Q++ T+
Sbjct: 1513 QEISDLTE 1520
Score = 95.1 bits (235), Expect = 3e-19
Identities = 119/628 (18%), Positives = 265/628 (42%), Gaps = 93/628 (14%)
Query: 144 RQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKD 203
+QA I +L+ QL+E ++ + L ++ + + + +RAL K
Sbjct: 1311 KQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKA 1370
Query: 204 EASKITIWKEQYRV--------VQEENQHMQMTIQALQDEL---------------RIQR 240
+++ W+ +Y ++E + + +QA ++ + R+Q
Sbjct: 1371 N-TEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429
Query: 241 DLNQLFQQDSSSRTGEPCVA-ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK 299
++ L RT C A + + NF ++ AE +++ +E + ++ + T+
Sbjct: 1430 EVEDLMLD--VERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTEL 1487
Query: 300 QTL-NARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENS 358
+ NA +ES+ +L E L+ + + + +E + T ++AE +H LE + +Q E+E
Sbjct: 1488 FKIKNAYEESLDQL-ETLKRENKNLQ--QEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544
Query: 359 MLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE 418
L+ + E + + + K L+ +E+ K S ++R + + +EEI LK N E
Sbjct: 1545 ELQAALEEA-EASLEHEEGKILRIQLELNQVK-SEVDRKIAEKDEEIDQLKRNHIRIVES 1602
Query: 419 REEEM--------------KQMEVYRSHSKFMKNKIGQVKQELSR--KDTELLALQTKLE 462
+ + K+ME + + N ++ E R ++T+ + T++
Sbjct: 1603 MQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 463 TLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE--------------- 507
D+ + E LKE L E+RA +LQ E++ LR LE+ E
Sbjct: 1663 -----LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717
Query: 508 ----------TMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVN---VLQKKIEN 554
+++N K K D+++ +G + + ++ + ++ + ++ ++++
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 555 LQEQLRDKEKQMSSLKERVKSLQADTTNTDT-ALTTLEEALAEKERTIERLKEQRDRDER 613
Q+ E+ ++++ VK LQ + AL ++ + + E + L+ + + +++
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK 1837
Query: 614 EKQEEIDNYKKDLKDLKE----------KVSLLQGDLSEKEASLLDLKEHASSLASSGLK 663
E + +K + +KE + LQ + + +A + K A
Sbjct: 1838 RNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNT 1897
Query: 664 KDSRLKTLEIALEQKKEECLKMESQLKK 691
++ + L+ LE+ +E ESQ+ K
Sbjct: 1898 NLAKFRKLQHELEEAEERADIAESQVNK 1925
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 149 bits (375), Expect = 2e-35
Identities = 186/837 (22%), Positives = 362/837 (43%), Gaps = 76/837 (9%)
Query: 142 SLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALR 201
+L++A T+ DLQ + +V N L + +++ E ++ S++ + ERA R
Sbjct: 1004 ALQEAHQQTLDDLQAEEDKV---NTLTKAKIKL-EQQVDDLEGSLEQEKKLRMDLERAKR 1059
Query: 202 KDEASKITIWKEQYRVVQEENQHM-------QMTIQALQDELRIQRDLNQLFQQDSSSRT 254
K E + + +E ++ E Q + + I LQ ++ ++ L Q +
Sbjct: 1060 KLEGD-LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG--IQLQKKIKE 1116
Query: 255 GEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLE 314
+ + EL EE + A + K+ L + LEE+ R+E +A+ E KK
Sbjct: 1117 LQARIEEL-EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1175
Query: 315 MLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDS 374
Q + HE T A + H +S+ E E+ +++ R + E +
Sbjct: 1176 EFQKMRRDLEEATLQHEATA----ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK 1231
Query: 375 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
+ L + +E ++E+ R LE+++ LKS EE++ + + R
Sbjct: 1232 MEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK----EEEQQRLINDLTAQRGR-- 1285
Query: 435 FMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQT 494
++ + G+ ++L K+ + L + T Q + K+ +E E + AK A LQ+
Sbjct: 1286 -LQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLE---EEIKAKNALAHALQS 1341
Query: 495 ---EVDALRLRLEEKETM-------LNKKTKQIQDMAEEKGTQAGE-IHDLKDMLDVKER 543
+ D LR + EE++ L+K ++ + T A + +L++ +
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1401
Query: 544 KVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIER 603
++ ++ +E + + EK L+ V+ L D T+ A L++ K+R ++
Sbjct: 1402 RLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK----KQRNFDK 1457
Query: 604 LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK-------EHASS 656
+ + + E E++ +K+ + L ++ ++ E L LK + S
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 657 LASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREI 716
L + R+ LE +Q ++E ++++ L++A EA+LE +I ++ E+
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEA-EASLEHEEG-----KILRIQLEL 1571
Query: 717 TRYKDESSKAQAEVDRLLEILKE-----VENEKNDKDKKIAELERQVKDQNKKVANLKHK 771
+ K E + AE D ++ LK VE+ ++ D +I ++ + K +L
Sbjct: 1572 NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631
Query: 772 E---QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAER 828
E + +A+ L R + L D+ L D+LR ++D E+L R + + AE
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEI 1691
Query: 829 EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAER 888
E + A E + + +ELL A E+V Q L + L +T++ L ET ++ ++ E
Sbjct: 1692 EELRATLEQTERSRKIAEQELLDASERV-QLLHTQNTSLINTKKKL---ETDISQMQGE- 1746
Query: 889 RKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLK 945
+E++L QEA A K A ++ KK Q+ A L+R K + Q +K
Sbjct: 1747 ---MEDIL---QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797
Score = 127 bits (318), Expect = 7e-29
Identities = 197/929 (21%), Positives = 407/929 (43%), Gaps = 117/929 (12%)
Query: 191 SPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDS 250
S E +KE A K+E KI + ++E + +T+ +++L++Q D+
Sbjct: 848 SAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADA 907
Query: 251 SSRTG---------EPCVAELTE--ENFQRLHAEHERQAKEL----FLLRKTLEEMELRI 295
R E + E+TE E+ + ++AE + ++L L+K ++++EL +
Sbjct: 908 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 296 ETQKQTLNARDESIKKLLEMLQSKGLS---AKATEEDHERTRRLAEAEMHVHHLESLLEQ 352
++ +A + +K L E + GL AK T+E + A E H L+ L +
Sbjct: 968 AKVEKEKHATENKVKNLTE--EMAGLDETIAKLTKE------KKALQEAHQQTLDDLQAE 1019
Query: 353 KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNG 412
++K N++ + ++ + E D L+ +E + +ER R LE ++++ +
Sbjct: 1020 EDKVNTLTKAKI--KLEQQVDD-----LEGSLEQEKKLRMDLERAKRKLEGDLKLAQE-- 1070
Query: 413 ALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSK 472
S + E E +Q++ +F +I ++ ++ + + LQ K++ L + + +
Sbjct: 1071 --SIMDIENEKQQLDEKLKKKEF---EISNLQSKIEDEQALGIQLQKKIKELQARIEELE 1125
Query: 473 QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK------ETMLNKKTKQIQDMAEEKGT 526
+ IE + S E++ + L E++ + RLEE + +NKK +
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1185
Query: 527 QAGEIHDLKDMLDVKERKVNV--LQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 584
+A H+ K+ +V L ++I+NLQ + EK+ S +K + L ++
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVS 1245
Query: 585 TALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKE 644
A LE+ E + LK K+EE DL + ++ G+ S +
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKS--------KEEEQQRLINDLTAQRGRLQTESGEFSRQ- 1296
Query: 645 ASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA-----HEAALEA 699
LD KE S S G K + + +E L+++ EE +K ++ L A H+ L
Sbjct: 1297 ---LDEKEALVSQLSRG--KQAFTQQIE-ELKRQLEEEIKAKNALAHALQSSRHDCDLLR 1350
Query: 700 RASPEMSDRIQHLEREITRYKDESSKAQAEVDR-LLEILKEVENEKNDKDKKIAELERQV 758
E + L+R +++ E ++ + + + ++ +E+E K +++ E V
Sbjct: 1351 EQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHV 1410
Query: 759 KDQNKKVANL-KHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEA 817
+ N K A+L K K++++ + ML+ R N + L R D + E ++
Sbjct: 1411 EAVNAKCASLEKTKQRLQNEVEDLMLDVERT-----NAACAALDKKQRNFDKILAEWKQK 1465
Query: 818 LRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEK 877
E+ E+ +Q+E+ E + ++ A E+ +LE++K + + QQ +++
Sbjct: 1466 CEET-----HAELEASQKEARSLGTE--LFKIKNAYEESLDQLETLKRENKNLQQEISD- 1517
Query: 878 ETHLTNLRAERRKHLEEVLEMKQEA------LLAAISEKDANIA-----LLELSSSKKKT 926
LT AE K + E+ ++K++ L AA+ E +A++ +L + +
Sbjct: 1518 ---LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQV 1574
Query: 927 QEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLL 986
+ EV EKD + QLK +N ++++ +S S S + I+
Sbjct: 1575 KSEVDRKIAEKDEEIDQLK---RNHIRIV---------ESMQSTLDAEIRSRNDAIRLKK 1622
Query: 987 ELDQNRSKLKLYIGHLTTLCHD--RDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQ- 1043
+++ + +++++ + H + + R+ +G+ +LDD + E+ +++ +
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVER 1682
Query: 1044 ----LQDELEKGERDNAELQEFANAILQQ 1068
LQ E+E+ R E E + I +Q
Sbjct: 1683 RANLLQAEIEE-LRATLEQTERSRKIAEQ 1710
Score = 123 bits (309), Expect = 8e-28
Identities = 153/749 (20%), Positives = 328/749 (43%), Gaps = 129/749 (17%)
Query: 414 LSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ 473
L + E E+EM M K + ++K EL++ + + L+ K+ TL + +D +
Sbjct: 846 LKSAETEKEMATM----------KEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 474 HIEVLKESLTAKEQRA-------AILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 526
++ E L E+R L+ ++ + R E++E + + T + + + +E
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 527 QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 586
+I DL+ L E++ + + K++NL E++ ++ ++ L + K+LQ +
Sbjct: 956 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ------EAH 1009
Query: 587 LTTLEEALAEKER--TIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKE 644
TL++ AE+++ T+ + K + ++ + + ++ KK DL+ L+GDL +
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069
Query: 645 ASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAH----------- 693
S++D++ L KK+ + L+ +E ++ ++++ ++K+
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE 1129
Query: 694 -EAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 752
E A A+A + SD + LE R ++ A+++ + +E E +K +D + A
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE--MNKKREAEFQKMRRDLEEA 1187
Query: 753 ELERQ-------------VKDQNKKVANLKH-KEQVEKKKSAQMLE--EARRREDNLNDS 796
L+ + V + +++ NL+ K+++EK+KS +E + + ++ +
Sbjct: 1188 TLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKA 1247
Query: 797 SQQLQDSLRKKDDRIEEL----EEALRESVQITAEREMVLAQE-ESARTNAEKQ--VEEL 849
L+ R +D++ EL EE R +TA+R + + E +R EK+ V +L
Sbjct: 1248 KGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQL 1307
Query: 850 LMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAER------RKHLEEVLEMKQEAL 903
+ Q++E +K +L ++ + K L++ R R+ EE E K E L
Sbjct: 1308 SRGKQAFTQQIEELKRQL---EEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAE-L 1363
Query: 904 LAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDH 963
A+S+ + +A + +T+ E A++R ++ +++ K++ R++ ++ E +
Sbjct: 1364 QRALSKANTEVA-------QWRTKYETDAIQRTEE--LEEAKKKLAQRLQAAEEHVEAVN 1414
Query: 964 FKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASY 1023
K + +T + L L L + C D
Sbjct: 1415 AKCASLEKTKQR------------LQNEVEDLMLDVERTNAACAALD---------KKQR 1453
Query: 1024 NLDDDQAAWENELQKMTRGQLQ------------------------DELEKGERDNAELQ 1059
N D A W+ + ++ T +L+ D+LE +R+N LQ
Sbjct: 1454 NFDKILAEWKQKCEE-THAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQ 1512
Query: 1060 EFANAILQQIADHCPDI--LEQVVNALEE 1086
+ + + +QIA+ I LE++ +E+
Sbjct: 1513 QEISDLTEQIAEGGKRIHELEKIKKQVEQ 1541
Score = 101 bits (252), Expect = 3e-21
Identities = 159/728 (21%), Positives = 295/728 (40%), Gaps = 136/728 (18%)
Query: 309 IKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRF 368
IK LL+ +++ A EE + LA++E LE + KE + L+ ++
Sbjct: 842 IKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEA 901
Query: 369 ENAPDSAKT--KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQM 426
E D+ + + ++T I++ ++KI + D EEEI N L+ ++R+ E +
Sbjct: 902 EGLADAEERCDQLIKTKIQL-EAKIKEVTERAED-EEEI-----NAELTAKKRKLEDECS 954
Query: 427 EVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVL----KESL 482
E +K I ++ L++ + E A + K++ LT + + + I L K
Sbjct: 955 E--------LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1006
Query: 483 TAKEQRAAILQTEVDAL------RLRLEEK----ETMLNKKTKQIQDMAEEKGTQAGE-- 530
A +Q LQ E D + +++LE++ E L ++ K D+ K G+
Sbjct: 1007 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1066
Query: 531 --------IHDLKDMLDVK-------------------------ERKVNVLQKKIENLQE 557
I + K LD K ++K+ LQ +IE L+E
Sbjct: 1067 LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE 1126
Query: 558 QLRDK-------EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR 610
++ + EKQ S L ++ + A T + K+R E K +RD
Sbjct: 1127 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA--TSAQIEMNKKREAEFQKMRRDL 1184
Query: 611 DEREKQEEI------DNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKK 664
+E Q E + + +L E++ LQ + E ++K LAS+
Sbjct: 1185 EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN---- 1240
Query: 665 DSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR-IQHLEREITRYKDES 723
++T+ A ++ C +E QL E ++ E R I L + R + ES
Sbjct: 1241 ---VETVSKAKGNLEKMCRTLEDQLS-------ELKSKEEEQQRLINDLTAQRGRLQTES 1290
Query: 724 SKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQML 783
+ ++D ++ ++ K ++I EL+RQ++++ K L H Q + +L
Sbjct: 1291 GEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQ-SSRHDCDLL 1349
Query: 784 EEARRREDNLNDSSQQLQDSLRKKD---------------DRIEELEEALRESVQ-ITAE 827
E E +S +LQ +L K + R EELEEA ++ Q + A
Sbjct: 1350 REQYEEE---QESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA 1406
Query: 828 REMV------LAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHL 881
E V A E + + +VE+L++ +E+ ++ K + + LAE +
Sbjct: 1407 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKC 1466
Query: 882 TNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLV 941
AE +E + E L ++ ++ +++ +++ LKRE L
Sbjct: 1467 EETHAELEASQKEARSLGTE--------------LFKIKNAYEESLDQLETLKRENKNLQ 1512
Query: 942 QQLKQQTQ 949
Q++ T+
Sbjct: 1513 QEISDLTE 1520
Score = 95.1 bits (235), Expect = 3e-19
Identities = 119/628 (18%), Positives = 265/628 (42%), Gaps = 93/628 (14%)
Query: 144 RQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKD 203
+QA I +L+ QL+E ++ + L ++ + + + +RAL K
Sbjct: 1311 KQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKA 1370
Query: 204 EASKITIWKEQYRV--------VQEENQHMQMTIQALQDEL---------------RIQR 240
+++ W+ +Y ++E + + +QA ++ + R+Q
Sbjct: 1371 N-TEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429
Query: 241 DLNQLFQQDSSSRTGEPCVA-ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK 299
++ L RT C A + + NF ++ AE +++ +E + ++ + T+
Sbjct: 1430 EVEDLMLD--VERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTEL 1487
Query: 300 QTL-NARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENS 358
+ NA +ES+ +L E L+ + + + +E + T ++AE +H LE + +Q E+E
Sbjct: 1488 FKIKNAYEESLDQL-ETLKRENKNLQ--QEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544
Query: 359 MLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE 418
L+ + E + + + K L+ +E+ K S ++R + + +EEI LK N E
Sbjct: 1545 ELQAALEEA-EASLEHEEGKILRIQLELNQVK-SEVDRKIAEKDEEIDQLKRNHIRIVES 1602
Query: 419 REEEM--------------KQMEVYRSHSKFMKNKIGQVKQELSR--KDTELLALQTKLE 462
+ + K+ME + + N ++ E R ++T+ + T++
Sbjct: 1603 MQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 463 TLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE--------------- 507
D+ + E LKE L E+RA +LQ E++ LR LE+ E
Sbjct: 1663 -----LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717
Query: 508 ----------TMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVN---VLQKKIEN 554
+++N K K D+++ +G + + ++ + ++ + ++ ++++
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 555 LQEQLRDKEKQMSSLKERVKSLQADTTNTDT-ALTTLEEALAEKERTIERLKEQRDRDER 613
Q+ E+ ++++ VK LQ + AL ++ + + E + L+ + + +++
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK 1837
Query: 614 EKQEEIDNYKKDLKDLKE----------KVSLLQGDLSEKEASLLDLKEHASSLASSGLK 663
E + +K + +KE + LQ + + +A + K A
Sbjct: 1838 RNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNT 1897
Query: 664 KDSRLKTLEIALEQKKEECLKMESQLKK 691
++ + L+ LE+ +E ESQ+ K
Sbjct: 1898 NLAKFRKLQHELEEAEERADIAESQVNK 1925
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 148 bits (373), Expect = 3e-35
Identities = 189/890 (21%), Positives = 389/890 (43%), Gaps = 138/890 (15%)
Query: 309 IKKLLEML-QSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR 367
+K LL++ Q + + AK E R ++LA AE + +E+L Q E L+E++
Sbjct: 834 VKPLLQVSRQEEEMMAKEEELVKVREKQLA-AENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 368 FENAPDSAKTKALQTVIEMKDSKIS-SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQM 426
E ++ + +A T + + +I +E + + EE Q L++ + +E +Q+
Sbjct: 893 TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
Query: 427 EVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKE 486
E S + ++ + + +L + + E + L+ + L + + I +LT +E
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE 1012
Query: 487 QRA---AILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKER 543
+++ A L+ + +A+ LEE+ L ++ KQ Q++ + + G+ DL D
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEER---LRREEKQRQELEKTRRKLEGDSTDLSD------- 1062
Query: 544 KVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIER 603
++ LQ +I L+ QL KE+++ + RV+ A + LE ++E + +E
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122
Query: 604 LKEQRDRDEREKQ---EEIDNYKKDLKDL--------------KEKVSLLQGDLSEK--- 643
+ R++ E++K+ EE++ K +L+D +++V++L+ L E+
Sbjct: 1123 ERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT 1182
Query: 644 -EASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARAS 702
EA + ++++ S ++ + K ++ LE+ K+ +L + L+ +
Sbjct: 1183 HEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD 1242
Query: 703 PE-----MSDRIQHL-------EREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKK 750
E + ++Q L ER T D+ +K Q E+D + +L + +++ + K
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302
Query: 751 IAELERQVKD-------QNKKVANLKHK-EQVEKKKSA--QMLEEARRREDNLNDS---- 796
+ LE Q++D +N++ +L K +QVE +K++ + LEE + NL
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362
Query: 797 SQQLQDSLRKKDDRI------EELEEALRESVQITAER--EMVLAQE--ESARTNAEKQV 846
Q+ D +K +D + EE++ L++ ++ ++R E V A + E +T ++++
Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL 1422
Query: 847 EELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAA 906
++LL+ ++ +Q +++ K Q LAE++T ER + E E + +AL A
Sbjct: 1423 DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLA 1482
Query: 907 ----------------------------ISEKDANIALLELSSSKKKTQEEVAALKREKD 938
S+ D ++ EL SK+ +++V +K + +
Sbjct: 1483 RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE 1542
Query: 939 RLVQQLKQQTQNRMKL------MADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR 992
L +L+ +++L M +E D ++ K Q+ + EL+ R
Sbjct: 1543 ELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDER 1602
Query: 993 SK--------------LKLYIGHLTTLCHDRDPLI-----LRGLTPPASYNLDDDQAAWE 1033
+ LK H+ + +RD I L+ LDD +A+ E
Sbjct: 1603 KQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE 1662
Query: 1034 NELQKMTRG------------QLQDELEKGERDNAELQEFANAILQQIAD 1071
L + QLQ+EL ER + Q+ + + +IA+
Sbjct: 1663 EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712
Score = 132 bits (333), Expect = 1e-30
Identities = 212/1082 (19%), Positives = 458/1082 (42%), Gaps = 185/1082 (17%)
Query: 146 ARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEA 205
A +N + +++T +++ E L++ ++ E++L + ++ + + ++ + D
Sbjct: 863 AAENRLTEMETLQSQLMAEKLQLQEQLQA-ETELCAEAEELRARLTAKKQELEEICHDLE 921
Query: 206 SKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEE 265
+++ +E+ + +Q E + MQ IQ L+++L + Q Q + T E + +L EE
Sbjct: 922 ARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKV--TTEAKLKKLEEE 979
Query: 266 NFQRLHAEHERQAKELFLLRKTLEEMELRI---ETQKQTLNARDESIKKLLEMLQSKGLS 322
L ++ + AKE LL + E + E + ++L + ++ L+ +
Sbjct: 980 QII-LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRR 1038
Query: 323 AKATEEDHERTRR------------LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFEN 370
+ ++ E+TRR +AE + + L+ L +KE+E L+ + R E
Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEE---LQAALARVEEE 1095
Query: 371 APDSAKTKALQTVIEMKDSKISSMERGL--------------RDLEEEIQMLKS------ 410
A + K AL+ + E+ +S+IS ++ L RDL EE++ LK+
Sbjct: 1096 A--AQKNMALKKIREL-ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTL 1152
Query: 411 -NGALSTE---EREEEM--------KQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQ 458
+ A E +RE+E+ ++ + + + + M+ K Q +EL+ + + ++
Sbjct: 1153 DSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVK 1212
Query: 459 TKLE----TLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKT 514
LE TL N+ + ++VL + E + ++ ++ L+++ E E + +
Sbjct: 1213 ANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELA 1272
Query: 515 KQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVK 574
++ + E G + + + L+ ++++ QE L+++ +Q SL ++K
Sbjct: 1273 DKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK 1332
Query: 575 SLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS 634
++ + + L EEA E+ I L Q D ++K E+ + +++K K
Sbjct: 1333 QVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQV-ADMKKKMEDSVGCLETAEEVKRK-- 1389
Query: 635 LLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKK--- 691
LQ DL + L + + L L + L+ +++ +E + KK
Sbjct: 1390 -LQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQ 1448
Query: 692 --AHEAALEARASPEMSDRIQHLERE-------ITRYKDESSKAQAEVDRLLEI----LK 738
A E + A+ + E DR + RE + R +E+ + +AE++RL + ++
Sbjct: 1449 LLAEEKTISAKYAEER-DRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEME 1507
Query: 739 EVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR-EDNLNDSS 797
++ + K+D K + ELE+ + ++V +K + + E + Q E+A+ R E NL
Sbjct: 1508 DLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE-ELEDELQATEDAKLRLEVNLQAMK 1566
Query: 798 QQLQDSLRKKDDRIEELEEAL----------------RESVQITAEREMVL------AQE 835
Q + L+ +D++ EE ++ L + S+ + A +++ + A
Sbjct: 1567 AQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHI 1626
Query: 836 ESARTNAEKQV------------------------EELLMAMEKVKQELESMKAKLSSTQ 871
+SA N ++ + EE+L ++ +++L+SM+A++ Q
Sbjct: 1627 DSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ 1686
Query: 872 QSLAEKETHLTNLRAERRKHLEEV----------LEMKQ--EALLAAISE---------- 909
+ LA E + ER + +E+ LE K+ EA +A + E
Sbjct: 1687 EELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTE 1746
Query: 910 ------KDANIALLELS-------SSKKKTQEEVAALKREKDRL---VQQLKQQTQNRMK 953
K AN+ + +++ S +K + L+R+ L +Q+++ +++ K
Sbjct: 1747 LINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYK 1806
Query: 954 LMADNYE----------DDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLT 1003
E D+ K + + + ++ LL++D R + Y
Sbjct: 1807 ASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQA- 1865
Query: 1004 TLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFAN 1063
D+ L+ L ++ Q A N ++ + +L+D E + N E+ N
Sbjct: 1866 ----DKASTRLKQLKRQLEEAEEEAQRA--NASRRKLQRELEDATETADAMNREVSSLKN 1919
Query: 1064 AI 1065
+
Sbjct: 1920 KL 1921
Score = 116 bits (291), Expect = 1e-25
Identities = 159/734 (21%), Positives = 319/734 (43%), Gaps = 82/734 (11%)
Query: 390 KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSR 449
++S E + EEE+ ++ L+ E R EM+ ++ S+ M K+ Q++++L +
Sbjct: 839 QVSRQEEEMMAKEEELVKVREK-QLAAENRLTEMETLQ-----SQLMAEKL-QLQEQL-Q 890
Query: 450 KDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK----EQRAAILQTEVDALRLRLEE 505
+TEL A + E L + + KQ +E + L A+ E+R LQ E ++ ++E
Sbjct: 891 AETELCA---EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQE 947
Query: 506 KETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQ 565
E L ++ Q + EK T ++ L++ + E + L K+ + L++++ +
Sbjct: 948 LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN 1007
Query: 566 MSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKD 625
++ +E+ KSL + +T LEE L +E++ R E EK + D
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITDLEERLR---------REEKQRQELEKTRR--KLEGD 1056
Query: 626 LKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKM 685
DL ++++ LQ ++E + L KE A + +++++ K + AL++ +E +
Sbjct: 1057 STDLSDQIAELQAQIAELKMQLAK-KEEELQAALARVEEEAAQKNM--ALKKIRE----L 1109
Query: 686 ESQLKKAHEAALEARASPEMSDRIQH-LEREITRYKDESSKAQAEVDRLLEILKEVENEK 744
ESQ+ + E RAS +++ + L E+ K E E+ + E E
Sbjct: 1110 ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEV 1169
Query: 745 NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSL 804
N K LE + K ++ ++ K ++ A+ LE+ +R + NL + Q L++
Sbjct: 1170 NILKK---TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENER 1226
Query: 805 RKKDDRIEEL------EEALRESVQITAEREMVLAQE-ESARTNAEKQVEELLMAME--- 854
+ + ++ L E R+ V+ + V E E RT +V +L + ++
Sbjct: 1227 GELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVT 1286
Query: 855 -----------KVKQELESMKAKLSSTQQSLAEKETHLTNLRA------ERRKHLEEVLE 897
K+ ++ +++++L TQ+ L E+ +L + + E LE
Sbjct: 1287 GLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLE 1346
Query: 898 MKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMAD 957
++EA EK +++ KKK ++ V L+ +++K++ Q ++ ++
Sbjct: 1347 EEEEA--KHNLEKQIATLHAQVADMKKKMEDSVGCLE-----TAEEVKRKLQKDLEGLSQ 1399
Query: 958 NYEDD--HFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILR 1015
+E+ + +T + D + L++LD R +L D L+
Sbjct: 1400 RHEEKVAAYDKLEKTKTRLQQELDDL---LVDLDHQRQS----ACNLEKKQKKFDQLLAE 1452
Query: 1016 GLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIAD--HC 1073
T A Y + D+A E ++ L LE+ AEL+ ++ D
Sbjct: 1453 EKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSS 1512
Query: 1074 PDILEQVVNALEES 1087
D + + V+ LE+S
Sbjct: 1513 KDDVGKSVHELEKS 1526
Score = 84.0 bits (206), Expect = 7e-16
Identities = 136/654 (20%), Positives = 264/654 (40%), Gaps = 124/654 (18%)
Query: 143 LRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSP--ELKKER-- 198
L Q + + L T+LK+V E + R+ +E +E + I T + ++KK+
Sbjct: 1316 LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMED 1375
Query: 199 ---ALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTG 255
L E K + K+ + Q + + + + + R+Q++L+ L D +
Sbjct: 1376 SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLV-DLDHQRQ 1434
Query: 256 EPCVAELTEENFQRLHAEH-------------------ERQAKELFLLRKTLEEMELRIE 296
C E ++ F +L AE E++ K L L R E ME + E
Sbjct: 1435 SACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE 1494
Query: 297 TQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKE 356
++ R E + +++ SK K+ E + R L E V +++ LE+ E E
Sbjct: 1495 LERLNKQFRTE----MEDLMSSKDDVGKSVHELEKSKRAL---EQQVEEMKTQLEELEDE 1547
Query: 357 -----NSMLREEMH---------RRFENAPDSAKTKALQTVIEMKDSKIS---------- 392
++ LR E++ R + + ++ K Q V ++++ +
Sbjct: 1548 LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSM 1607
Query: 393 ------SMERGLRDLEEEIQMLKSNGALSTEE---------------------REEEMKQ 425
+E L+DLE I N + ++ REE + Q
Sbjct: 1608 AVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ 1667
Query: 426 MEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK 485
+ K M+ ++ Q+++EL+ + Q + + L ++ ++S + E
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727
Query: 486 EQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV 545
E R A L+ E LEE++ T+ I D ++ Q +I+ D+ +
Sbjct: 1728 EARIAQLEEE-------LEEEQ----GNTELINDRLKKANLQIDQIN-----TDLNLERS 1771
Query: 546 NVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK 605
+ +K EN ++QL E+Q LK +++ ++ T + + ++ E I +L+
Sbjct: 1772 HA--QKNENARQQL---ERQNKELKVKLQEMEG------TVKSKYKASITALEAKIAQLE 1820
Query: 606 EQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKD 665
EQ D + +E+Q ++ K LK+ LLQ D D + +A K
Sbjct: 1821 EQLDNETKERQAACKQVRRTEKKLKD--VLLQVD---------DERRNAEQYKDQADKAS 1869
Query: 666 SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPE-MSDRIQHLEREITR 718
+RLK L+ LE+ +EE + + +K +A + + M+ + L+ ++ R
Sbjct: 1870 TRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 144 bits (364), Expect = 3e-34
Identities = 179/814 (21%), Positives = 356/814 (43%), Gaps = 149/814 (18%)
Query: 293 LRIETQKQTLNARDESIKKLLE------------------MLQSKGLSAKATE------- 327
L++ Q++ L A+DE + K+ E +L+ K + A+ +
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 328 EDHERTRRLA----EAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTV 383
E E RLA E E +H LES +E++E+ N +L+ E K +Q
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNE-------------KKKMQAH 951
Query: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRS----HSKFMKNK 439
I+ + ++ E G R +++Q+ K ++ EEE+ +E S K M+++
Sbjct: 952 IQDLEEQLDE-EEGAR---QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR 1007
Query: 440 IGQVKQELSRKDTE---LLALQTKLETLTNQFSD-------SKQHIEVLKESL----TAK 485
I + +L+ ++ + L ++ K E + + + ++Q +E K L T
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDL 1067
Query: 486 EQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV 545
+ + A LQ ++D L+L+L +KE L + D K + +L + ++
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL-------QAQI 1120
Query: 546 NVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK 605
LQ+ E+ + EKQ L E +++L+ + +T +E ++E+ + LK
Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1180
Query: 606 EQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS--GLK 663
+ +EE N++ ++D++++ + +LSE+ L K ++L + GL+
Sbjct: 1181 -------KALEEETKNHEAQIQDMRQRHATALEELSEQ---LEQAKRFKANLEKNKQGLE 1230
Query: 664 KDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDES 723
D++ E+A E K + +K ES+ K+ L+A+ E+ ++ +R +++
Sbjct: 1231 TDNK----ELACEVKVLQQVKAESEHKR---KKLDAQVQ-ELHAKVSEGDRLRVELAEKA 1282
Query: 724 SKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKD-------QNKKVANLKHK-EQVE 775
SK Q E+D + +L+E E + K A LE Q++D + ++ NL + Q+E
Sbjct: 1283 SKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLE 1342
Query: 776 KKKSAQMLEEARRREDNLNDSSQ------QLQDSLRKKDD---RIEELEEALRESV---- 822
++K++ ++ E N Q QL D+ +K DD IE LEEA ++ +
Sbjct: 1343 EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE 1402
Query: 823 ---QITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKET 879
Q E+ + + E + ++++++L + ++ +Q +++ K Q LAE+++
Sbjct: 1403 ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS 1462
Query: 880 HLTNLRAER-----------------RKHLEEVLEMKQE------ALLAAI-----SEKD 911
ER + LEE LE K+E L A + S+ D
Sbjct: 1463 ISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDD 1522
Query: 912 ANIALLELSSSKKKTQEEVAALKREKDRLVQQL------KQQTQNRMKLMADNYEDDHFK 965
+ EL SK+ +++V ++ + + L +L K + + M+ M +E D
Sbjct: 1523 VGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT 1582
Query: 966 SSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYI 999
N+ + Q+ + EL+ R + L +
Sbjct: 1583 RDEQNEEKKRLLIKQVRELEAELEDERKQRALAV 1616
Score = 143 bits (361), Expect = 8e-34
Identities = 196/912 (21%), Positives = 408/912 (44%), Gaps = 124/912 (13%)
Query: 148 DNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASK 207
+ + +++ + +++L E ++L + ++ E++L + ++ + + ++ + D S+
Sbjct: 872 EGELEEMERKHQQLLEEKNILAEQLQA-ETELFAEAEEMRARLAAKKQELEEILHDLESR 930
Query: 208 ITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENF 267
+ +E+ +++Q E + MQ IQ L+++L + Q Q + T E + ++ EE
Sbjct: 931 VEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKV--TAEAKIKKM-EEEI 987
Query: 268 QRLHAEHERQAKELFLLRKTLEEMELRIETQKQTL-------NARDESIKKLLEMLQSKG 320
L ++ + KE L+ + E ++ +++ N ++ I L E L+ +
Sbjct: 988 LLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEE 1047
Query: 321 LSAKATEE-----DHERTR---RLAEAEMHVHHLESLLEQKEKE--NSMLR---EEMHRR 367
+ + E+ D E T ++AE + + L+ L +KE+E ++ R E +H+
Sbjct: 1048 KTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107
Query: 368 FENAPD-----SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSN--GALSTEERE 420
NA A+ LQ E + + + E+ RDL EE++ LK+ L T +
Sbjct: 1108 --NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQ 1165
Query: 421 EEMKQM------EVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTN---QFSDS 471
+E++ E+ ++ + KN Q++ R T L L +LE +
Sbjct: 1166 QELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKN 1225
Query: 472 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQ----DMAEEKGTQ 527
KQ +E + L + + ++ E + R +L+ + L+ K + ++AE+
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKL 1285
Query: 528 AGEIHDLKDMLDVKERK-------VNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADT 580
E+ ++ +L+ E+K L+ ++++ QE L+++ +Q +L R++ L+ +
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345
Query: 581 TNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDL 640
+ EEA E+ + L+ Q D ++K ++ + L++ K+K+
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQL-ADTKKKVDDDLGTIESLEEAKKKLL------ 1398
Query: 641 SEKEASLLDLKEHASSLASSGLKK-----DSRLKTLEIALEQKKEECLKMESQLKK---- 691
K+A L + +LA L+K L L + L+ +++ +E + KK
Sbjct: 1399 --KDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQL 1456
Query: 692 -AHEAALEARASPEMSDRIQHLERE-------ITRYKDESSKAQAEVDR----LLEILKE 739
A E ++ AR + E DR + RE + R +E+ +A+ E +R L +++
Sbjct: 1457 LAEEKSISARYAEER-DRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED 1515
Query: 740 VENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR-EDNLNDSSQ 798
+ + K+D K + ELE+ + ++V ++ + + E + Q E+A+ R E N+
Sbjct: 1516 LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE-ELEDELQATEDAKLRLEVNMQAMKA 1574
Query: 799 QLQDSLRKKDDRIEELEEALRESVQ----------------ITAEREMVL------AQEE 836
Q + L+ +D++ EE + L + V+ + ++++M + AQ E
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIE 1634
Query: 837 SA---RTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLE 893
+A R KQ+ +L M+ ++ELE +A E E L +L AE + L+
Sbjct: 1635 AANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQ-LQ 1693
Query: 894 EVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ------Q 947
E L + A A E+D EL+ + +AL EK RL ++ Q +
Sbjct: 1694 EELASSERARRHAEQERD------ELADEITNSASGKSALLDEKRRLEARIAQLEEELEE 1747
Query: 948 TQNRMKLMADNY 959
Q+ M+L+ D +
Sbjct: 1748 EQSNMELLNDRF 1759
Score = 140 bits (353), Expect = 7e-33
Identities = 169/774 (21%), Positives = 349/774 (45%), Gaps = 103/774 (13%)
Query: 152 MDLQTQ-LKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITI 210
+D Q Q L + E D LR ++ K SKL + ++++ T KK KD AS +
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 211 WKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL 270
++ ++QEE + +L + + QL ++ +S + + EE R
Sbjct: 1317 LQDTQELLQEETRQ----------KLNLSSRIRQLEEEKNSLQEQQE------EEEEARK 1360
Query: 271 HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQ--SKGLSAKATEE 328
+ E K++ L+ L + + +++ T+ + +E+ KKLL+ + S+ L KA
Sbjct: 1361 NLE-----KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415
Query: 329 DH-ERTRRLAEAEM--------HVHHLESLLEQKEKE-NSMLREE--MHRRFENAPDSAK 376
D E+T+ + E+ H + S LE+K+K+ + +L EE + R+ D A+
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475
Query: 377 TKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFM 436
+A + K++K S+ R L + E + EE E + KQ+
Sbjct: 1476 AEARE-----KETKALSLARALEEALE-----------AKEEFERQNKQLRADMEDLMSS 1519
Query: 437 KNKIGQVKQELSRK----DTELLALQTKLETLTNQFS---DSKQHIEVLKESLTAKEQRA 489
K+ +G+ EL + + ++ ++T+LE L ++ D+K +EV +++ A+ +R
Sbjct: 1520 KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERD 1579
Query: 490 AILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAG-----------EIHDLKDML 538
LQT + + EEK+ +L K+ ++++ E++ Q ++ DL+ +
Sbjct: 1580 --LQTRDE----QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI 1633
Query: 539 DVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKE 598
+ + + + K++ LQ Q++D ++++ + + A + ++ L +LE + + +
Sbjct: 1634 EAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQ 1693
Query: 599 RTI---ERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHAS 655
+ ER + +++ E +EI N L ++ L+ +++ E L + + +
Sbjct: 1694 EELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNME 1753
Query: 656 SLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLERE 715
L K ++ TL L ++ K ++ ++ R + E+ ++Q LE
Sbjct: 1754 LLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLE------RQNKELKAKLQELEGA 1807
Query: 716 I-TRYKDESSKAQAEVDRLLEILKEVENEK-------NDKDKKIAELERQVKDQNKKVAN 767
+ +++K S +A++ +L E L++ E+ +KK+ E+ QV+D+ +
Sbjct: 1808 VKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHAD- 1866
Query: 768 LKHKEQVEK-----KKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESV 822
++KEQ+EK K+ + LEEA N S ++LQ R+ DD E E RE
Sbjct: 1867 -QYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ---RELDDATEANEGLSREVS 1922
Query: 823 QITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAE 876
+ S+ + +Q+ ++E + ES + ++ TQ +E
Sbjct: 1923 TLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQPPQSE 1976
Score = 139 bits (351), Expect = 1e-32
Identities = 172/779 (22%), Positives = 352/779 (45%), Gaps = 128/779 (16%)
Query: 273 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKK----LLEMLQSKG-LSAKATE 327
E E QAK+ LL+ ++E + ++E + + + + + + + L E LQ++ L A+A E
Sbjct: 851 EEELQAKDEELLK--VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEE 908
Query: 328 EDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMK 387
+ E E +H LES +E++E+ N +L+ E K +Q I+
Sbjct: 909 MRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK-------------KKMQAHIQDL 955
Query: 388 DSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRS----HSKFMKNKIGQV 443
+ ++ E G R +++Q+ K ++ EEE+ +E S K M+++I +
Sbjct: 956 EEQLDE-EEGAR---QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 444 KQELSRKDTE---LLALQTKLETLTNQFSD-------SKQHIEVLKESL----TAKEQRA 489
+L+ ++ + L ++ K E + + + ++Q +E K L T + +
Sbjct: 1012 SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071
Query: 490 AILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQ 549
A LQ ++D L+L+L +KE L + D K + +L + ++ LQ
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL-------QAQIAELQ 1124
Query: 550 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD 609
+ E+ + EKQ L E +++L+ + +T +E ++E+ + LK
Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK---- 1180
Query: 610 RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS--GLKKDSR 667
+ +EE N++ ++D++++ + +LSE+ L K ++L + GL+ D++
Sbjct: 1181 ---KALEEETKNHEAQIQDMRQRHATALEELSEQ---LEQAKRFKANLEKNKQGLETDNK 1234
Query: 668 LKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ 727
E+A E K + +K ES+ K+ L+A+ E+ ++ +R +++SK Q
Sbjct: 1235 ----ELACEVKVLQQVKAESEHKRKK---LDAQVQ-ELHAKVSEGDRLRVELAEKASKLQ 1286
Query: 728 AEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEAR 787
E+D + +L+E E + K A LE Q++D + ++L+E
Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQD------------------TQELLQEET 1328
Query: 788 RREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESART------- 840
R++ NL+ +QL++ ++ EE EEA + E++++ Q + A T
Sbjct: 1329 RQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK-----NLEKQVLALQSQLADTKKKVDDD 1383
Query: 841 -----NAEKQVEELLMAMEKVKQELESMKA---KLSSTQQSLAEKETHLTNLRAERRKHL 892
+ E+ ++LL E + Q LE KL T+ L ++ LT + + ++ +
Sbjct: 1384 LGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLT-VDLDHQRQV 1442
Query: 893 EEVLEMKQEALLAAISEKDANIA-------LLELSSSKKKTQ--------EEVAALKREK 937
LE KQ+ ++E+ + A E + +K+T+ EE K E
Sbjct: 1443 ASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEF 1502
Query: 938 DRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLK 996
+R +QL+ ++ M + +DD K+ H + + + Q+ + +L++ +L+
Sbjct: 1503 ERQNKQLRADMEDLM-----SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ 1556
Score = 134 bits (338), Expect = 4e-31
Identities = 169/818 (20%), Positives = 354/818 (43%), Gaps = 83/818 (10%)
Query: 151 IMDLQTQLKEVLREND---LLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASK 207
+ +LQ Q+ E+ + + R E ++ LS + ++KT L A ++ +
Sbjct: 1113 VRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR 1172
Query: 208 ITIWKEQYRVVQEENQHMQMTIQALQ-------DELRIQRDLNQLFQQD-SSSRTG-EPC 258
E + ++EE ++ + IQ ++ +EL Q + + F+ + ++ G E
Sbjct: 1173 EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD 1232
Query: 259 VAELTEEN--FQRLHAEHERQAKELF-----LLRKTLEEMELRIETQKQTLNARDE--SI 309
EL E Q++ AE E + K+L L K E LR+E ++ ++E ++
Sbjct: 1233 NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV 1292
Query: 310 KKLLEMLQSKGLS----AKATEEDHERTRRLAEAEMHVH-HLESLLEQKEKENSMLREEM 364
LLE + KG+ A + E + T+ L + E +L S + Q E+E + L+E+
Sbjct: 1293 STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ 1352
Query: 365 HRRFENAPDSAK-TKALQTVIEMKDSKISSMERGLRDLEE-EIQMLKSNGALSTEEREEE 422
E + K ALQ+ + K+ + LEE + ++LK ALS E+
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKA 1412
Query: 423 MKQMEVYRSHSKFMK---------NKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ 473
+ ++ ++ ++ + + QV L +K + L + ++++ ++++ +
Sbjct: 1413 LAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERD 1472
Query: 474 HIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHD 533
E KE +A L ++ EE E + ++D+ K +H+
Sbjct: 1473 RAEA---EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE 1529
Query: 534 LKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEA 593
L+ E++V ++ ++E L+++L+ E L+ +++++A + L T +E
Sbjct: 1530 LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQF---ERDLQTRDEQ 1586
Query: 594 LAEKERT----IERLKEQRDRDEREKQEEIDNYKK---DLKDLKEKVSL----------- 635
EK+R + L+ + + + +++ + + KK DLKDL+ ++
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1646
Query: 636 ---LQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA 692
LQ + + + L + + + + + + +LK+LE + Q +EE E + A
Sbjct: 1647 LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHA 1706
Query: 693 HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 752
+ E++D I + + DE + +A + +L E L+E ++ + +
Sbjct: 1707 EQER------DELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760
Query: 753 ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKK----- 807
+ QV N ++A E+ +KS ++ R+ L Q+L+ +++ K
Sbjct: 1761 KTTLQVDTLNAELA----AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI 1816
Query: 808 ---DDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMK 864
+ +I +LEE L + + A ++ + E QVE+ ++ K+++E
Sbjct: 1817 SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKAN 1876
Query: 865 AKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEA 902
A++ ++ L E E T A RRK L+ L+ EA
Sbjct: 1877 ARMKQLKRQLEEAEEEATRANASRRK-LQRELDDATEA 1913
Score = 119 bits (299), Expect = 1e-26
Identities = 146/668 (21%), Positives = 296/668 (44%), Gaps = 85/668 (12%)
Query: 439 KIGQVKQELSRKDTELLALQTKLETLTNQFSD-SKQHIEVLKESLTAKEQRAAILQTEVD 497
++ + ++EL KD ELL ++ K + + + ++H ++L+E EQ LQ E +
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQ----LQAETE 901
Query: 498 ALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE 557
L EE L K ++++++ +HDL+ ++ +E + +LQ + + +Q
Sbjct: 902 -LFAEAEEMRARLAAKKQELEEI----------LHDLESRVEEEEERNQILQNEKKKMQA 950
Query: 558 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQE 617
++D E+Q+ + + LQ + + + +EE + L++Q + +EK+
Sbjct: 951 HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEIL-------LLEDQNSKFIKEKK- 1002
Query: 618 EIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQ 677
L++ ++E + L + +E A +LA K++ + LE L
Sbjct: 1003 -----------------LMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERL-- 1043
Query: 678 KKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEIL 737
KKEE K +L+KA + L+ + ++ D+I L+ +I K + +K + E+ L
Sbjct: 1044 KKEE--KTRQELEKA-KRKLDGETT-DLQDQIAELQAQIDELKLQLAKKEEELQGALARG 1099
Query: 738 KEVENEKNDKDKKIAELERQVKDQNKKVANLK---HKEQVEKKKSAQMLEEARRREDNLN 794
+ KN+ K + EL+ Q+ + + + K +K + +K+ ++ LE + ++
Sbjct: 1100 DDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTL 1159
Query: 795 DSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAME 854
D++ Q+ K++ + EL++AL E T E + A +++ E L +
Sbjct: 1160 DTTAAQQELRTKREQEVAELKKALEEE---TKNHEAQIQDMRQRHATALEELSEQLEQAK 1216
Query: 855 KVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKD-AN 913
+ K LE K L + + LA + L ++AE +H + L+ + + L A +SE D
Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAE-SEHKRKKLDAQVQELHAKVSEGDRLR 1275
Query: 914 IALLELSSSKKKTQEEVAALKREKDRL-------VQQLKQQTQNRMKLMADNYEDDHFKS 966
+ L E +S + + V+ L E ++ L+ Q Q+ +L+ + S
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 967 SHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLD 1026
S Q + + Q Q E ++ R L ++ L L+ +D
Sbjct: 1336 SRIRQLEEEKNSLQEQQE--EEEEARKNL------------EKQVLALQSQLADTKKKVD 1381
Query: 1027 DDQAAWENELQKMTRGQLQD------ELEKGERDNAELQEFANAILQQIADHCPDI--LE 1078
DD E+ L++ + L+D LE+ +L++ N + Q++ D D+
Sbjct: 1382 DDLGTIES-LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQR 1440
Query: 1079 QVVNALEE 1086
QV + LE+
Sbjct: 1441 QVASNLEK 1448
Score = 77.0 bits (188), Expect = 9e-14
Identities = 131/657 (19%), Positives = 261/657 (39%), Gaps = 104/657 (15%)
Query: 146 ARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIK--------TFWSPELKKE 197
+R + + + L+E E + RK++E + L S + K T S E K+
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 198 RALRKDEASKITIWKEQ--YRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSS--- 252
+ L+ EA + ++ Y +++ +Q + L +L QR + ++
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 253 -RTGEPCVAELTEENFQRLHAE-HERQAKELFLLRKTLEEMELRIETQKQT--------- 301
E ++ E R AE E++ K L L R E +E + E ++Q
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED 1515
Query: 302 -LNARDESIKKLLEMLQSKGLSAKATEEDHERTRRL---------AEAEMHVH------- 344
++++D+ K + E+ +SK + EE + L A+ + V+
Sbjct: 1516 LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQ 1575
Query: 345 ---HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDL 401
L++ EQ E++ +L +++ D K +AL + K ME L+DL
Sbjct: 1576 FERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK------MEIDLKDL 1629
Query: 402 EEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVK--------------QEL 447
E +I+ + + R+E +KQ+ ++ K + ++ + + ++L
Sbjct: 1630 EAQIEA-------ANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKL 1682
Query: 448 SRKDTELLALQTKL--------------ETLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 493
+ E+L LQ +L + L ++ ++S L + E R A L+
Sbjct: 1683 KSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742
Query: 494 TEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIE 553
E++ + +E K T Q+ + E + + ER+ L+ K++
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 554 NLQEQLRDKEK-QMSSLKERVKSLQADTTNTDTALTTLEEALAEK--ERTIERLKEQRDR 610
L+ ++ K K +S+L+ ++ L+ E A A K RT ++LKE +
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQ-----EAKERAAANKLVRRTEKKLKEIFMQ 1857
Query: 611 DEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKT 670
E E++ D YK+ ++ ++ L+ L E E E A+ +S K L
Sbjct: 1858 VEDERR-HADQYKEQMEKANARMKQLKRQLEEAE-------EEATRANASRRKLQRELDD 1909
Query: 671 LEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ 727
A E E ++++L++ + +S R HLE D+ ++++
Sbjct: 1910 ATEANEGLSREVSTLKNRLRRGGPISF---SSSRSGRRQLHLEGASLELSDDDTESK 1963
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 144 bits (362), Expect = 6e-34
Identities = 200/860 (23%), Positives = 375/860 (43%), Gaps = 104/860 (12%)
Query: 133 VSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESK--LSSSMNSIKTFW 190
+S + SL++A T+ DLQ + +V N L++ + ++++ L S+ K
Sbjct: 993 ISKLTKEKKSLQEAHQQTLDDLQVEEDKV---NGLIKINAKLEQQTDDLEGSLEQEKKL- 1048
Query: 191 SPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDS 250
ERA RK E + Q ++ EN Q+ + + E + + ++ +
Sbjct: 1049 --RADLERAKRKLEGD---LKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQV 1103
Query: 251 SSRTGEPCVAELT---EENFQRLHAEHERQAK---ELFLLRKTLEEMELRIETQKQTLNA 304
S + + EL EE + + AEH +AK + L + LEE+ R+E +A
Sbjct: 1104 HSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSA 1163
Query: 305 RDESIKKLLEMLQSKGLSAKATEEDHERTRR---------LAEAEMHVHHLESLLEQKEK 355
+ E KK Q + HE T +AE + +L+ + ++ EK
Sbjct: 1164 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEK 1223
Query: 356 ENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALS 415
E S L+ E+ N +K+K S++ER R +E++ +K+
Sbjct: 1224 EKSELKMEIDDMASNIEALSKSK-------------SNIERTCRTVEDQFSEIKAKD--- 1267
Query: 416 TEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHI 475
E++ + + + + ++ ++ + G++ + K++ + L + LT Q + K+ +
Sbjct: 1268 -EQQTQLIHDLNMQKAR---LQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQM 1323
Query: 476 EVLKESLTAKEQRAAILQT---EVDALRLRLEEKETM-------LNKKTKQIQDMAEEKG 525
E E AK A LQ+ + D LR + EE++ L+K ++ +
Sbjct: 1324 E---EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYE 1380
Query: 526 TQAGEIHDLKDMLDVKERKVNVLQKKIENLQ---EQLRDKEKQMSSLKERVKSLQADTTN 582
T A I +++ + K++ LQ+ EN + + EK L+ V+ L D
Sbjct: 1381 TDA--IQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLER 1438
Query: 583 TDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSE 642
+ TA TL++ ++ + K++ D E Q E++ +K+ + L ++ ++ E
Sbjct: 1439 SHTACATLDKKQRNFDKVLAEWKQKLD----ESQAELEAAQKESRSLSTELFKMRNAYEE 1494
Query: 643 KEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARAS 702
L L+ +L ++ L Q+ E+ K+ Q K + ALE
Sbjct: 1495 VVDQLETLRRENKNLQEEISDLTEQIAETGKNL-QEAEKTKKLVEQEKSDLQVALE---- 1549
Query: 703 PEMSDRIQHLEREITRYKDESSKAQAEVDR-LLEILKEVENEKNDKDKKIAELERQVKDQ 761
E+ ++H E +I R + E S+ ++E+DR ++E +E+E K + ++ AE + V D
Sbjct: 1550 -EVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNS-QRAAEALQSVLDA 1607
Query: 762 NKKVAN--LKHKEQVE-------------KKKSAQMLEEARRREDNLNDSSQQLQDSLRK 806
+ N L+ K+++E ++ A+ + R + L DS L D+LR
Sbjct: 1608 EIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRS 1667
Query: 807 KDDRIEELEEALRESVQITAE-REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKA 865
+D E+L R + + E EM +A E++ RT + +ELL A ++V Q L S
Sbjct: 1668 NEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSE-QELLDASDRV-QLLHSQNT 1725
Query: 866 KLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKK 925
L +T++ L E + +AE ++E +++A A DA + EL KK
Sbjct: 1726 SLINTKKKL---EADIAQCQAEVENSIQESRNAEEKAKKAI---TDAAMMAEEL----KK 1775
Query: 926 TQEEVAALKREKDRLVQQLK 945
Q+ A L+R K L Q +K
Sbjct: 1776 EQDTSAHLERMKKNLEQTVK 1795
Score = 143 bits (360), Expect = 1e-33
Identities = 160/715 (22%), Positives = 320/715 (44%), Gaps = 93/715 (13%)
Query: 414 LSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ 473
L + E E+EM M K + K+EL+R + L+ K+ +L + +D +
Sbjct: 844 LKSAEAEKEMATM----------KEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQL 893
Query: 474 HIEVLKESLTAKEQRAA-------ILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 526
++ E+L E+R +L+ +V L RLEE+E M ++ + +++ ++ +
Sbjct: 894 QVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSS 953
Query: 527 QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 586
+I DL+ L E++ + + K++NL E++ E+ +S L + KSLQ T
Sbjct: 954 LKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDD 1013
Query: 587 LTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEAS 646
L E+ + + +L++Q D E ++E KK DL+ L+GDL + S
Sbjct: 1014 LQVEEDKVNGLIKINAKLEQQTDDLEGSLEQE----KKLRADLERAKRKLEGDLKMSQES 1069
Query: 647 LLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAH------------E 694
++DL+ + KK+ L L+ ++ ++ L+ + ++K+ E
Sbjct: 1070 IMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE 1129
Query: 695 AALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAEL 754
L A+ + SD + LE R ++ S A+++ + +E E +K +D + A L
Sbjct: 1130 HTLRAKIEKQRSDLARELEEISERLEEASGATSAQIE--MNKKREAEFQKMRRDLEEATL 1187
Query: 755 ERQV------KDQNKKVANL--------KHKEQVEKKKSAQMLE--EARRREDNLNDSSQ 798
+ + K Q VA L + K+++EK+KS +E + + L+ S
Sbjct: 1188 QHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKS 1247
Query: 799 QLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQ 858
++ + R +D+ E++ + Q+ + M A+ ++ +VEE + ++ +
Sbjct: 1248 NIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTK 1307
Query: 859 ELESMKAKLSSTQQSLAEKETHLTNLRA---ERRKH----LEEVLEMKQEA---LLAAIS 908
+++ +L ++ + E+ET N A + +H L E E +QEA L A+S
Sbjct: 1308 SKQALTQQLEELKRQM-EEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALS 1366
Query: 909 EKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSH 968
+ ++ +A + +T+ E A++R ++ +++ K++ R++ +N E + K +
Sbjct: 1367 KANSEVA-------QWRTKYETDAIQRTEE--LEEAKKKLAQRLQEAEENTETANSKCAS 1417
Query: 969 SNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDD 1028
+T + + ++ L+ D RS H D+ + LD+
Sbjct: 1418 LEKTKQRLQGE--VEDLMR-DLERS-------HTACATLDKKQRNFDKVLAEWKQKLDES 1467
Query: 1029 QAAWE----------NELQKMTRG--QLQDELEKGERDNAELQEFANAILQQIAD 1071
QA E EL KM ++ D+LE R+N LQE + + +QIA+
Sbjct: 1468 QAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAE 1522
Score = 130 bits (328), Expect = 5e-30
Identities = 177/880 (20%), Positives = 382/880 (43%), Gaps = 118/880 (13%)
Query: 157 QLKEVLRENDLLRKDVEVKESKLSSSMNSIK--------TFWSPELKKERALRKDE--AS 206
+L E L E + + ++ K+ L +S+K T E +K K + +
Sbjct: 925 ELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSE 984
Query: 207 KITIWKEQYRVVQEENQHMQMTIQALQDELRIQRD-------LNQLFQQDSSSRTGEPCV 259
++T +E + +E + +Q Q D+L+++ D +N +Q + G
Sbjct: 985 EMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEG---- 1040
Query: 260 AELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK 319
+ E ++L A+ ER ++L K +E + +E KQ + + + + L LQ+K
Sbjct: 1041 ---SLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAK 1097
Query: 320 -----GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDS 374
S + ++ E R+ E E + +L + EK+ S L E+ E ++
Sbjct: 1098 IDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEA 1157
Query: 375 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
+ + Q IEM + + ++ RDLEE ++ A +++ + + ++ + +
Sbjct: 1158 SGATSAQ--IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQ 1215
Query: 435 FMKNKIGQVKQELSRKDTELLA-----------LQTKLETLTNQFSDSKQHIEVLKESLT 483
+K K+ + K EL + ++ + ++ T+ +QFS+ K E + +
Sbjct: 1216 RVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH 1275
Query: 484 AKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKER 543
+ A LQT+ L R+EEKE+++++ TK Q + ++ + +LK ++ + +
Sbjct: 1276 DLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQ-------LEELKRQMEEETK 1328
Query: 544 KVNVLQKKIEN-------LQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAE 596
N + +++ L+EQ ++++ + L+ + ++ T T +A+
Sbjct: 1329 AKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYET--DAIQR 1386
Query: 597 KERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASS 656
E +E K++ + +E +E + L++ LQG++ E + DL+ ++
Sbjct: 1387 TEE-LEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEV---EDLMRDLERSHTA 1442
Query: 657 LASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEA----RASPEMSDRIQHL 712
A+ K+ + K L ++ E ++E+ K++ + E A E+ D+++ L
Sbjct: 1443 CATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETL 1502
Query: 713 EREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKE 772
RE ++E S ++ + L+E E K +++ ++L+ +++ +L+H+E
Sbjct: 1503 RRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVE---GSLEHEE 1559
Query: 773 QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVL 832
+ R + L+ +L + +KD+ IE+L+ R S + + VL
Sbjct: 1560 S-----------KILRVQLELSQVKSELDRKVIEKDEEIEQLK---RNSQRAAEALQSVL 1605
Query: 833 AQEESARTNA-------EKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTN-L 884
E +R +A E + E+ + + +++ + L + Q L + + HL + L
Sbjct: 1606 DAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDAL 1665
Query: 885 RA-----------ERRKH--LEEVLEMK----QEALLAAISEKDA-----NIALL----- 917
R+ ERR LEE+ EMK Q +SE++ + LL
Sbjct: 1666 RSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNT 1725
Query: 918 ELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMAD 957
L ++KKK + ++A + E + +Q+ + + K + D
Sbjct: 1726 SLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITD 1765
Score = 124 bits (311), Expect = 5e-28
Identities = 191/925 (20%), Positives = 394/925 (42%), Gaps = 127/925 (13%)
Query: 143 LRQARDNTIMDLQTQLKEVLRENDL---LRKDVEVKES------KLSSSMNSIKTFW--- 190
L + RD ++ L T + V R + +K +E ++S + S MN W
Sbjct: 777 LEEMRDEKLVTLMTSTQAVCRGYLMRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNL 836
Query: 191 ---------SPELKKERALRKD--EASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQ 239
S E +KE A K+ E +K + + + R + E + + + + +L++Q
Sbjct: 837 FFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQ 896
Query: 240 RDLNQLFQQDS-------SSRTGEPCVAELTEENFQRLHAEHERQAKELFL------LRK 286
+ L + S E V ELTE + E AK+ L L++
Sbjct: 897 SETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKR 956
Query: 287 TLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEA--EMHVH 344
++++EL + ++ +A + +K L E + A EE+ + + ++ E H
Sbjct: 957 DIDDLELTLTKVEKEKHATENKVKNLSEEMT-------ALEENISKLTKEKKSLQEAHQQ 1009
Query: 345 HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE 404
L+ L +++K N +++ NA +T L+ +E + + +ER R LE +
Sbjct: 1010 TLDDLQVEEDKVNGLIKI-------NAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGD 1062
Query: 405 IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETL 464
++M + S + E + +Q+E +F ++ Q++ ++ + L Q K++ L
Sbjct: 1063 LKMSQE----SIMDLENDKQQIEEKLKKKEF---ELSQLQAKIDDEQVHSLQFQKKIKEL 1115
Query: 465 TNQFSDSKQHIEVLKESLTAK-EQRAAILQTEVDALRLRLEEKE-------TMLNKKTKQ 516
+ + ++ IE + +L AK E++ + L E++ + RLEE M K+ +
Sbjct: 1116 QARIEELEEEIEA-EHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAE 1174
Query: 517 IQDMAEEKGTQAGEIHDLKDMLDVKER-KVNVLQKKIENLQEQLRDKEKQMSSLKERVKS 575
Q M + + L K+ V L ++I+NLQ + EK+ S LK +
Sbjct: 1175 FQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDD 1234
Query: 576 LQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 635
+ ++ + L ++ + ERT +++Q + + K E+ DL K ++
Sbjct: 1235 MASN-------IEALSKSKSNIERTCRTVEDQFS-EIKAKDEQQTQLIHDLNMQKARLQT 1286
Query: 636 LQGDLS----EKEASLLDLKEHASSLASS------GLKKDSRLKT-LEIALEQKKEECLK 684
G+LS EKE+ + L + +L ++++++ K + AL+ + +C
Sbjct: 1287 QNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDL 1346
Query: 685 MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD----RLLEILKEV 740
+ Q ++ EA E + + +S + + T+Y+ ++ + E++ +L + L+E
Sbjct: 1347 LREQYEEEQEAKAELQRA--LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA 1404
Query: 741 ENEKNDKDKKIAELE--------------RQVKDQNKKVANLKHKEQVEKKKSA---QML 783
E + K A LE R ++ + A L K++ K A Q L
Sbjct: 1405 EENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKL 1464
Query: 784 EEARRREDNLNDSSQQLQDSLRKKDDRIEE--------------LEEALRESVQITAERE 829
+E++ + S+ L L K + EE L+E + + + AE
Sbjct: 1465 DESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETG 1524
Query: 830 MVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERR 889
L + E + E++ +L +A+E+V+ LE ++K+ Q L++ ++ L E+
Sbjct: 1525 KNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKD 1584
Query: 890 KHLEEVLEMKQEALLAAISEKDANI-ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQT 948
+ +E++ Q A A S DA I + + KKK + ++ ++ + +Q+ +T
Sbjct: 1585 EEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQM-AET 1643
Query: 949 QNRMKLMADNYEDDHFKSSHSNQTN 973
Q ++ + +D + ++N
Sbjct: 1644 QKHLRTVQGQLKDSQLHLDDALRSN 1668
Score = 119 bits (298), Expect = 2e-26
Identities = 158/812 (19%), Positives = 338/812 (41%), Gaps = 100/812 (12%)
Query: 141 HSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL 200
H+LR + DL +L+E+ ++ L + +++ + F E A
Sbjct: 1130 HTLRAKIEKQRSDLARELEEI---SERLEEASGATSAQIEMNKKREAEFQKMRRDLEEAT 1186
Query: 201 RKDEASKITIWKEQYRVVQEEN------QHMQMTIQALQDELRIQ-RDLNQLFQQDSSSR 253
+ EA+ T+ K+Q V E Q ++ ++ + EL+++ D+ + S S+
Sbjct: 1187 LQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSK 1246
Query: 254 TGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 313
+ E+ F + A+ E+Q + L L + R++TQ L+ R E + L+
Sbjct: 1247 SNIERTCRTVEDQFSEIKAKDEQQTQ----LIHDLNMQKARLQTQNGELSHRVEEKESLI 1302
Query: 314 EMLQSKGLSA--------KATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
L + + EE+ + +A A H LL ++ +E + E+
Sbjct: 1303 SQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQ 1362
Query: 366 RRFENAPDSA-------KTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGAL--ST 416
R A +T A+Q E++++K +R L++ EE + S A T
Sbjct: 1363 RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR-LQEAEENTETANSKCASLEKT 1421
Query: 417 EER-----EEEMKQMEVYRSHS------KFMKN---KIGQVKQELSRKDTELLALQTKLE 462
++R E+ M+ +E RSH+ K +N + + KQ+L EL A Q +
Sbjct: 1422 KQRLQGEVEDLMRDLE--RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESR 1479
Query: 463 TLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAE 522
+L+ + + E + + L + LQ E+ L ++ E L + K + + +
Sbjct: 1480 SLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQ 1539
Query: 523 EKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN 582
EK + +++ L+ +E K+ +Q ++ ++ +L ++++ E ++ L+ ++
Sbjct: 1540 EKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSEL---DRKVIEKDEEIEQLKRNSQR 1596
Query: 583 TDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSE 642
AL ++ +A RLK++ + D E + ++ + + + + ++ + +QG L +
Sbjct: 1597 AAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKD 1656
Query: 643 KEASL-------LDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQL------ 689
+ L DLKE + + L+ +++ALEQ + E +L
Sbjct: 1657 SQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDR 1716
Query: 690 --------------KKAHEAALEARASPEMSDRIQHLEREITRYK----------DESSK 725
KK EA + A+ E+ + IQ + K +E K
Sbjct: 1717 VQLLHSQNTSLINTKKKLEADI-AQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKK 1775
Query: 726 AQAEVDRLLEILKEVENEKNDKDKKIAELE--------RQVKDQNKKVANLKHKEQVEKK 777
Q L + K +E D ++ E E +Q++ +V L+++ VE+K
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQK 1835
Query: 778 KSAQMLEEARRREDNLNDSSQQLQD---SLRKKDDRIEELEEALRESVQITAEREMVLAQ 834
+ A+ L+ A + E + + + Q ++ ++ + D +++L+ ++ + E E
Sbjct: 1836 RGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANT 1895
Query: 835 EESARTNAEKQVEELLMAMEKVKQELESMKAK 866
+ S + ++EE + + ++ ++AK
Sbjct: 1896 QLSRCRRVQHELEEAAERADIAESQVNKLRAK 1927
Score = 110 bits (275), Expect = 7e-24
Identities = 135/634 (21%), Positives = 276/634 (43%), Gaps = 86/634 (13%)
Query: 160 EVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDE--------ASKITIW 211
++LRE ++ + + + S NS W + + + R +E A ++
Sbjct: 1345 DLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA 1404
Query: 212 KEQYRVVQEENQHMQMTIQALQDELR-IQRDLNQLFQQ----DSSSRTGEPCVAELTEE- 265
+E + ++ T Q LQ E+ + RDL + D R + +AE ++
Sbjct: 1405 EENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKL 1464
Query: 266 -----NFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKG 320
+ E + ELF +R EE+ ++ET ++ E I L E + G
Sbjct: 1465 DESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETG 1524
Query: 321 LSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKAL 380
+ ++ E+T++L E E L+ LE E E S+ EE +K L
Sbjct: 1525 KNL----QEAEKTKKLVEQEKS--DLQVALE--EVEGSLEHEE-------------SKIL 1563
Query: 381 QTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE----EMKQMEVYRSHSKFM 436
+ +E+ K S ++R + + +EEI+ LK N + E + E++ K M
Sbjct: 1564 RVQLELSQVK-SELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKM 1622
Query: 437 KNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHI-------EVLKESLTAKEQRA 489
+ + +++ +L + ++ Q L T+ Q DS+ H+ E LKE L E+R
Sbjct: 1623 EGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRN 1682
Query: 490 AILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQ 549
+L E++ +++ LE+ E +++ D ++ + L + E + Q
Sbjct: 1683 GLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQ 1742
Query: 550 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT---IERLKE 606
++EN ++ R+ E+ +A TD A+ + E L +++ T +ER+K+
Sbjct: 1743 AEVENSIQESRNAEE------------KAKKAITDAAM--MAEELKKEQDTSAHLERMKK 1788
Query: 607 QRDRDEREKQEEIDNYKK-DLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKK- 664
++ ++ Q +D ++ LK K+++ L+ + E E + LD+++ + A G K
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELE-NELDVEQKRGAEALKGAHKY 1847
Query: 665 DSRLKTLEIALEQKKEECL-----------KMESQLKKAHEAALEARASPEMSDRIQHLE 713
+ ++K + E+ + L K++S ++A EA +A R+QH
Sbjct: 1848 ERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQH-- 1905
Query: 714 REITRYKDESSKAQAEVDRLLEILKEVENEKNDK 747
E+ + + A+++V++L ++V ++K ++
Sbjct: 1906 -ELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 141 bits (355), Expect = 4e-33
Identities = 163/867 (18%), Positives = 379/867 (43%), Gaps = 111/867 (12%)
Query: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 213
L+ + E+ ++ D L + E + ++ N +K L +E A + +K+T +
Sbjct: 947 LEDECSELKKDIDDLELTLAKVEKEKHATENKVKN-----LTEEMAGLDETIAKLT---K 998
Query: 214 QYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAE 273
+ + +QE +Q +QA +D++ +Q G + E +++ +
Sbjct: 999 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEG-------SLEQEKKIRMD 1051
Query: 274 HERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDH--- 330
ER ++L K +E + IE KQ L DE +KK + + GL +K +E
Sbjct: 1052 LERAKRKLEGDLKLAQESTMDIENDKQQL---DEKLKK--KEFEMSGLQSKIEDEQALGM 1106
Query: 331 ERTRRLAEAEMHVHHLESLLEQK-------EKENSMLREEMHRRFENAPDSAKTKALQTV 383
+ +++ E + + LE +E + EK+ S L E+ E ++ + Q
Sbjct: 1107 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ-- 1164
Query: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQV 443
IEM + + ++ RDLEE ++ A ++ + + ++ + + +V
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE-------QIDNLQRV 1217
Query: 444 KQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRL 503
KQ+L ++ +E+ K+E D ++E + ++ E+ L+ ++ ++ +
Sbjct: 1218 KQKLEKEKSEM-----KME-----IDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKE 1267
Query: 504 EEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKE 563
EE++ ++N T Q + E G + ++ + ++ R ++IE L+ QL ++
Sbjct: 1268 EEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEI 1327
Query: 564 KQMSSLKERVKS-------LQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQ 616
K S+L ++S L+ A L+ A+++ + + + + + D ++
Sbjct: 1328 KAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRT 1387
Query: 617 EEIDNYKKD----LKDLKEKVSLLQGDL-----------SEKEASLLDLKEHASSLASSG 661
EE++ KK L+D +E V + +E E ++D++ ++ A+
Sbjct: 1388 EELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALD 1447
Query: 662 LKKDSRLKTL------------EIALEQKKEECLKME-SQLKKAHEAALEARASPEMSDR 708
K+ + K L E+ QK+ L E ++K A+E +L+ + + ++
Sbjct: 1448 KKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENK 1507
Query: 709 IQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANL 768
+L++EI+ ++ ++ + L +I K+VE EK++ + E E ++ + K+ +
Sbjct: 1508 --NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRI 1565
Query: 769 -----KHKEQVEKK--KSAQMLEEARRREDNLNDSSQQLQDS-LRKKDDRI--------- 811
+ K +V++K + + +++ +R + +S Q D+ +R ++D I
Sbjct: 1566 QLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD 1625
Query: 812 -EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSST 870
E+E L + ++ AE ++ + + +++ L + E +K++L ++ + +
Sbjct: 1626 LNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLL 1685
Query: 871 QQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEV 930
Q + E L R+ +E+L+ + L L ++KKK + ++
Sbjct: 1686 QAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQN-------TSLINTKKKLETDI 1738
Query: 931 AALKREKDRLVQQLKQQTQNRMKLMAD 957
+ ++ E + ++Q+ + + K + D
Sbjct: 1739 SQIQGEMEDIIQEARNAEEKAKKAITD 1765
Score = 127 bits (320), Expect = 4e-29
Identities = 194/948 (20%), Positives = 381/948 (40%), Gaps = 203/948 (21%)
Query: 142 SLRQARDNTIMDLQTQLKEV--------------------LRENDLLRKDVEVKESKLSS 181
+L++A T+ DLQ + +V L + +R D+E + KL
Sbjct: 1002 ALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEG 1061
Query: 182 SMN----------SIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQA 231
+ + K +LKK+ SKI + +Q++ + +Q I+
Sbjct: 1062 DLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEE 1121
Query: 232 LQDELRIQRDLNQLFQQDSSSRTGE-PCVAELTEENFQRLHAEHERQAK---ELFLLRKT 287
L++E+ +R ++ S + E ++E EE A+ E K E +R+
Sbjct: 1122 LEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1181
Query: 288 LEEMELRIETQKQTLNARD-ESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHL 346
LEE L+ E TL + +S+ +L E + + + E++ +E +M + L
Sbjct: 1182 LEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEK------SEMKMEIDDL 1235
Query: 347 ESLLEQKEKENSMLREEMHRRFENAPDSAKTKA----------------LQTV------- 383
S +E K L E+M R E+ KTK LQT
Sbjct: 1236 ASNMETVSKAKGNL-EKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQ 1294
Query: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMK--------------QMEVY 429
++ KD+ +S + RG + ++I+ LK + EEE+K ++
Sbjct: 1295 LDEKDTLVSQLSRGKQAFTQQIEELK-------RQLEEEIKAKSALAHALQSSRHDCDLL 1347
Query: 430 RSHSKFMKNKIGQVKQELSRKDTELLALQTKLET---------------LTNQFSDSKQH 474
R + + ++++ +S+ ++E+ +TK ET L + D+++H
Sbjct: 1348 REQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEH 1407
Query: 475 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKETM---LNKKTKQIQDMAEEKGTQAGEI 531
+E + + E+ LQ EV+ L + +E L+KK + + E + E
Sbjct: 1408 VEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEET 1467
Query: 532 H-------------------------DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQM 566
H + D L+ +R+ LQ++I +L EQ+ + K++
Sbjct: 1468 HAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRI 1527
Query: 567 SSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERL-------KEQRDRDEREKQEEI 619
L++ K ++ + + AL E +L +E I R+ K + DR EK EEI
Sbjct: 1528 HELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1587
Query: 620 DNYKK---------------DLKDLKEKVSL---LQGDLSEKEASLLDLKEHASSLASSG 661
D K+ +++ + + L ++GDL+E E L HA+ +A+
Sbjct: 1588 DQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQL----NHANRMAAEA 1643
Query: 662 LKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARAS------PEMSDRIQHLERE 715
L+ + + + ++ L+ + LK+ A +E RA+ E+ ++ ER
Sbjct: 1644 LRNYRNTQAILKDTQLHLDDALRSQEDLKE-QLAMVERRANLLQAEIEELRATLEQTERS 1702
Query: 716 ITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVE 775
+ E A V L + N K + I++++ +++D ++ N + K +
Sbjct: 1703 RKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKA 1762
Query: 776 KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE 835
+A M EE ++ +D +S L+ + + +++L+ L E+ Q+
Sbjct: 1763 ITDAAMMAEELKKEQD----TSAHLERMKKNLEQTVKDLQHRLDEAEQL----------- 1807
Query: 836 ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 895
A +KQ+++L + +++ E+ES + + + L RKH +V
Sbjct: 1808 --ALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGL--------------RKHERKV 1851
Query: 896 LEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQ 943
E+ + +E+D +L L K Q +V + KR+ + +Q
Sbjct: 1852 KELTYQ------TEEDRK-NILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892
Score = 111 bits (277), Expect = 4e-24
Identities = 159/775 (20%), Positives = 328/775 (42%), Gaps = 86/775 (11%)
Query: 142 SLRQARDNTIMDLQTQLKEVLRENDLLRKD---VEVKESKLSSSMNSIKTFWSPELKKER 198
+LR+ +++ +L Q+ + R L K+ ++++ L+S+M ++ K R
Sbjct: 1195 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCR 1254
Query: 199 ALRKDEASKI-TIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQD---SSSRT 254
AL +D+ S+I T +EQ R++ + +T Q + + QL ++D S
Sbjct: 1255 AL-EDQLSEIKTKEEEQQRLIND------LTAQRARLQTESGEYSRQLDEKDTLVSQLSR 1307
Query: 255 GEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLE 314
G+ + EE ++L E + ++ L+ + + +L E ++ A+ E L+
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAE-----LQ 1362
Query: 315 MLQSKGLSAKA-------------TEEDHERTRRLAE----AEMHVHHLESLLEQKEKEN 357
SK S A TEE E ++LA+ AE HV + + EK
Sbjct: 1363 RAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTK 1422
Query: 358 SMLREEMHRRFENAPDSAKTKALQTVIEMK----DSKISSMERGLRDLEEEIQML-KSNG 412
L+ E+ + D +T A ++ K D ++ ++ + E++ K +
Sbjct: 1423 QRLQNEVE---DLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESR 1479
Query: 413 ALSTE------EREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTN 466
+LSTE EE + Q+E + +K ++ +I + ++++ + L+ + +
Sbjct: 1480 SLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ 1539
Query: 467 QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 526
+ S+ + +E + SL +E + +Q E++ ++ ++ K + +K ++I M K
Sbjct: 1540 EKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK---IAEKDEEIDQM---KRN 1593
Query: 527 QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 586
+ ++ LD + R N + + ++ L + E Q++ + NT
Sbjct: 1594 HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAI 1653
Query: 587 LTTLEEALAEKERTIERLKEQRDRDEREK---QEEIDNYKKDLKDLKEKVSLLQGDLSEK 643
L + L + R+ E LKEQ ER Q EI+ + L+ + + + +L +
Sbjct: 1654 LKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA 1713
Query: 644 EASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA-HEAALEARAS 702
+ L +SL ++ K ++ + ++ +E +E E + KKA +AA+ A
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEEL 1773
Query: 703 PEMSDRIQHLER----------EITRYKDESSK-----AQAEVDRLLEILKEVENEKNDK 747
+ D HLER ++ DE+ + + ++ +L ++E+E E +
Sbjct: 1774 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESE 1833
Query: 748 DKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKK 807
K+ E + ++ +KV L ++ EE R+ L D +LQ ++
Sbjct: 1834 QKRNVEAVKGLRKHERKVKELTYQ-----------TEEDRKNILRLQDLVDKLQAKVKSY 1882
Query: 808 DDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELES 862
+ EE EE ++ + L + E AE QV +L + +V ++ S
Sbjct: 1883 KRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIIS 1937
Score = 101 bits (252), Expect = 3e-21
Identities = 109/543 (20%), Positives = 244/543 (44%), Gaps = 83/543 (15%)
Query: 414 LSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ 473
L + E E+EM M K + + K+EL++ + + L+ K+ TL + +D +
Sbjct: 844 LKSAETEKEMANM----------KEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893
Query: 474 HIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHD 533
++ +SL E+R +L + + L K K++ + AE++ E+
Sbjct: 894 QVQAEADSLADAEERCD-----------QLIKTKIQLEAKIKEVTERAEDEEEINAELTA 942
Query: 534 LKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEA 593
K L E + + L+K I++L+ L EK+ + + +VK+L + D + L
Sbjct: 943 KKRKL---EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL--- 996
Query: 594 LAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEH 653
++++ ++ +Q D + ++++++ K L+++V L+G L ++
Sbjct: 997 -TKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE---------- 1045
Query: 654 ASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLE 713
K + + LE+ K K+E LK A E+ ++ +D+ Q L+
Sbjct: 1046 ---------------KKIRMDLERAKR---KLEGDLKLAQESTMDIE-----NDK-QQLD 1081
Query: 714 REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQ 773
++ + + E S Q++++ + +++ + + +I ELE +++ + A K +
Sbjct: 1082 EKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRA----KAE 1137
Query: 774 VEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLA 833
++ ++ LEE R + ++ + +K++ +++ L E+ T + E A
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEA---TLQHEATAA 1194
Query: 834 QEESARTNAEKQVEELLMAMEKVKQELESMKAK-------LSSTQQSLAEKETHLTNLRA 886
++ ++ E + +++VKQ+LE K++ L+S +++++ + +L +
Sbjct: 1195 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCR 1254
Query: 887 ERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ 946
L E+ + K+E I++ A A L+ S + Q + EKD LV QL +
Sbjct: 1255 ALEDQLSEI-KTKEEEQQRLINDLTAQRARLQTESGEYSRQLD------EKDTLVSQLSR 1307
Query: 947 QTQ 949
Q
Sbjct: 1308 GKQ 1310
Score = 64.3 bits (155), Expect = 6e-10
Identities = 90/458 (19%), Positives = 195/458 (42%), Gaps = 80/458 (17%)
Query: 155 QTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQ 214
+++L+ L E + + E K ++ +N +K+ E+ ++ A + +E ++ +
Sbjct: 1541 KSELQAALEEAEASLEHEEGKILRIQLELNQVKS----EVDRKIAEKDEEIDQMK--RNH 1594
Query: 215 YRVVQEENQHMQMTIQALQDELRIQR----DLNQLFQQDSSSRTGEPCVAELTEENFQRL 270
R+V+ + I++ D +R+++ DLN++ E+ + R+
Sbjct: 1595 IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM---------------EIQLNHANRM 1639
Query: 271 HAEHERQAKEL-FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEED 329
AE R + +L+ T ++ + +Q+ L + +++ +LQ++ +AT E
Sbjct: 1640 AAEALRNYRNTQAILKDTQLHLDDALRSQED-LKEQLAMVERRANLLQAEIEELRATLEQ 1698
Query: 330 HERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDS 389
ER+R++AE E LL+ E+ + +N K L+T I
Sbjct: 1699 TERSRKIAEQE--------LLDASERVQLL-------HTQNTSLINTKKKLETDISQIQG 1743
Query: 390 KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSR 449
++ + + R+ EE+ + ++ A+ EE ++E +H + MK + Q ++L
Sbjct: 1744 EMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTS----AHLERMKKNLEQTVKDLQH 1799
Query: 450 K--DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE 507
+ + E LAL+ K+ I+ L E R L+ EV++ + R E
Sbjct: 1800 RLDEAEQLALK-----------GGKKQIQKL-------EARVRELEGEVESEQKRNVEAV 1841
Query: 508 TMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV--------------NVLQKKIE 553
L K ++++++ + I L+D++D + KV NV K
Sbjct: 1842 KGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFR 1901
Query: 554 NLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE 591
+Q +L + E++ + +V L+ + T + + E
Sbjct: 1902 RIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE 1939
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 141 bits (355), Expect = 4e-33
Identities = 183/837 (21%), Positives = 356/837 (42%), Gaps = 76/837 (9%)
Query: 142 SLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALR 201
+L++A T+ DLQ + +V + L K E ++ S++ + ERA R
Sbjct: 1002 ALQEAHQQTLDDLQMEEDKV----NTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKR 1057
Query: 202 KDEASKITIWKEQYRVVQEENQHMQMTIQALQDEL-----RIQRDLNQLFQQDSSSRTGE 256
K E + + +E + + Q + ++ + E+ +I+ + Q + +
Sbjct: 1058 KLEGD-LKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQ 1116
Query: 257 PCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEML 316
+ EL EE + A + K+ L + LEE+ R+E +A+ E KK
Sbjct: 1117 ARIEEL-EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEF 1175
Query: 317 QSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAK 376
Q + + HE T A + H +S+ E E+ +S+ R + E + +
Sbjct: 1176 QKMRRDLEESTLQHEATA----AALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKME 1231
Query: 377 TKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFM 436
L + +E ++ E+ R LE+++ +K+ + EE+ + + + +
Sbjct: 1232 INDLASNMETVSKAKANFEKMCRTLEDQLSEIKT-------KEEEQQRLINELSAQKARL 1284
Query: 437 KNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQT-- 494
+ G+ ++L KD + L + T Q + K+ +E E AK A LQ+
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLE---EETKAKSTLAHALQSAR 1341
Query: 495 -EVDALRLRLEEKETM-------LNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVN 546
+ D LR + EE++ ++K ++ + T A I +++ + K++
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDA--IQRTEELEEAKKKLAQ 1399
Query: 547 VLQ---KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIER 603
LQ + +E + + EK L+ V+ L D ++ A L++ K+R ++
Sbjct: 1400 RLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDK----KQRNFDK 1455
Query: 604 LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK-------EHASS 656
+ + + E Q E++ +K+ + L ++ ++ E L LK + S
Sbjct: 1456 VLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISD 1515
Query: 657 LASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREI 716
L + + LE +Q E ++++ L++A EA+LE +I ++ E+
Sbjct: 1516 LTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEA-EASLEHEEG-----KILRIQLEL 1569
Query: 717 TRYKDESSKAQAEVDRLLEILKE-----VENEKNDKDKKIAELERQVKDQNKKVANLKHK 771
+ K E + AE D L+ LK VE+ ++ D +I ++ + K +L
Sbjct: 1570 NQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEM 1629
Query: 772 E---QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAER 828
E +++A+ L R + L D+ L D++R +DD E+L R + + AE
Sbjct: 1630 EIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEV 1689
Query: 829 EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAER 888
E + A E + +ELL A E+V Q L + L +T++ L ET ++ ++ E
Sbjct: 1690 EELRASLERTERGRKMAEQELLDASERV-QLLHTQNTSLINTKKKL---ETDISQIQGE- 1744
Query: 889 RKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLK 945
+E+++ QEA A K A ++ KK Q+ A L+R K + Q +K
Sbjct: 1745 ---MEDIV---QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1795
Score = 136 bits (343), Expect = 9e-32
Identities = 175/916 (19%), Positives = 391/916 (42%), Gaps = 102/916 (11%)
Query: 150 TIMDLQTQLKEVLR---ENDLLRKDVEVKESKLSSSMNSIKT------FWSPELKKERAL 200
T + L+ ++KEV + + + ++ K+ KL + +K +++KE+
Sbjct: 915 TKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 974
Query: 201 RKDEASKITI----WKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGE 256
+++ +T E + +E + +Q Q D+L+++ D + + +
Sbjct: 975 TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQ 1034
Query: 257 PCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEML 316
E + E ++L + ER ++L K +E + E KQ LN + + + + L
Sbjct: 1035 VDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNL 1094
Query: 317 QSK-----GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENA 371
Q K L+ + ++ E R+ E E + + + EK+ S L E+ E
Sbjct: 1095 QGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154
Query: 372 PDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRS 431
++ + Q IEM + + ++ RDLEE ++ A ++ + + ++
Sbjct: 1155 EEAGGATSAQ--IEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGE--- 1209
Query: 432 HSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAI 491
+ + +VKQ+L ++ +EL K+E +D ++E + ++ E+
Sbjct: 1210 ----QIDSLQRVKQKLEKEKSEL-----KME-----INDLASNMETVSKAKANFEKMCRT 1255
Query: 492 LQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKK 551
L+ ++ ++ + EE++ ++N+ + Q + E G + ++ + M+ R ++
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQ 1315
Query: 552 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRD 611
IE L+ QL ++ K S+L ++S + D +EA AE +R + + + +
Sbjct: 1316 IEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQW 1375
Query: 612 EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTL 671
+ + + ++L++ K+K L L + E + + +SL + + + ++ L
Sbjct: 1376 RTKYETDAIQRTEELEEAKKK---LAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDL 1432
Query: 672 EIALEQKKEECLKMESQLKKAHEAALEARASPEMSD-RIQHLEREITRYKDESSKAQAEV 730
I +E+ C+ ++ + + + E + E + ++ ++E E K +
Sbjct: 1433 MIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAY 1492
Query: 731 DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANL-KHKEQVEKKKSAQM--LEEAR 787
+ L+ L+ ++ E + ++I++L Q+ + K + L K K+Q++ +KS LEEA
Sbjct: 1493 EESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAE 1552
Query: 788 -----------RREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEE 836
R + LN ++ + +KD EEL++ R +++ + L E
Sbjct: 1553 ASLEHEEGKILRIQLELNQVKSEIDRKIAEKD---EELDQLKRNHLRVVESMQSTLDAEI 1609
Query: 837 SARTNA-------EKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNL----- 884
+R +A E + E+ + + ++ L +TQ L + + HL +
Sbjct: 1610 RSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQD 1669
Query: 885 -------RAERRKHL--EEVLEMKQEALLAAISEKDANIALLELS--------------S 921
ERR +L EV E++ K A LL+ S +
Sbjct: 1670 DLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLIN 1729
Query: 922 SKKKTQEEVAALKREKDRLVQQLKQQTQNRMK------LMADNYEDDHFKSSHSNQTNHK 975
+KKK + +++ ++ E + +VQ+ + + K +MA+ + + S+H + K
Sbjct: 1730 TKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM--K 1787
Query: 976 PSPDQIIQPL-LELDQ 990
+ +Q ++ L L LD+
Sbjct: 1788 KNMEQTVKDLQLRLDE 1803
Score = 129 bits (325), Expect = 1e-29
Identities = 175/799 (21%), Positives = 345/799 (43%), Gaps = 95/799 (11%)
Query: 191 SPELKKERA------------LRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELR- 237
S E +KE A L K EA + + ++ ++QE+N +Q+ +QA D L
Sbjct: 846 SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKND-LQLQVQAEADALAD 904
Query: 238 IQRDLNQLFQQDSSSRTGEPCVAELTEENFQ---RLHAEHERQAKELFLLRKTLEEMELR 294
+ +QL + V E E+ + L A+ + E L+K ++++EL
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 964
Query: 295 IETQKQTLNARDESIKKLLEMLQSKGLS---AKATEEDHERTRRLAEAEMHVHHLESLLE 351
+ ++ +A + +K L E + GL AK T+E + A E H L+ L
Sbjct: 965 LAKVEKEKHATENKVKNLTE--EMAGLDETIAKLTKE------KKALQEAHQQTLDDLQM 1016
Query: 352 QKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSN 411
+++K N++ + + + E D L+ +E + +ER R LE ++++ +
Sbjct: 1017 EEDKVNTLTKAK--TKLEQQVDD-----LEGSLEQEKKLCMDLERAKRKLEGDLKLAQE- 1068
Query: 412 GALSTEEREEEMKQMEVYRSHSKF-MKNKIGQVKQELSRKDTELLALQTKLETLTNQFSD 470
ST + E + +Q+ +F M N G+++ E + LQ K++ L + +
Sbjct: 1069 ---STMDTENDKQQLNEKLKKKEFEMSNLQGKIEDE----QALAIQLQKKIKELQARIEE 1121
Query: 471 SKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEE------KETMLNKKTK-QIQDMAEE 523
++ IE + S E++ + L E++ + RLEE + +NKK + + Q M +
Sbjct: 1122 LEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1181
Query: 524 KGTQAGEIHDLKDMLDVKER-KVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN 582
+ L K V L ++I++LQ + EK+ S LK + L ++
Sbjct: 1182 LEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMET 1241
Query: 583 TDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSE 642
A E+ RT+E + E E+Q I+ L + L E
Sbjct: 1242 VSKAKANFEKMC----RTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDE 1297
Query: 643 KEASLLDLKEHASSLASS------GLKKDSRLK-TLEIALEQKKEECLKMESQLKKAHEA 695
K+A + L + L+++++ K TL AL+ + +C + Q ++ EA
Sbjct: 1298 KDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEA 1357
Query: 696 ALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE 755
E + MS + + T+Y+ ++ ++ +E+E K +++ + E
Sbjct: 1358 KAELQRG--MSKANSEVAQWRTKYETDA----------IQRTEELEEAKKKLAQRLQDAE 1405
Query: 756 RQVKDQNKKVANL-KHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 814
V+ N K A+L K K++++ + M++ R N + L R D + E
Sbjct: 1406 EHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERS-----NAACIALDKKQRNFDKVLAEW 1460
Query: 815 EEALRESVQITAEREMVLAQEESARTNAE-----KQVEELLMAMEKVKQELESMKAKLSS 869
++ E+ + E+ +Q+ES + E EE L +E +K+E ++++ ++S
Sbjct: 1461 KQKYEET-----QAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISD 1515
Query: 870 TQQSLAEKETHLTNLRAERRK--HLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQ 927
+ +AE H+ L +++ H + L+ E A++ ++ I ++L ++ K+
Sbjct: 1516 LTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKS- 1574
Query: 928 EEVAALKREKDRLVQQLKQ 946
E+ EKD + QLK+
Sbjct: 1575 -EIDRKIAEKDEELDQLKR 1592
Score = 124 bits (311), Expect = 5e-28
Identities = 190/924 (20%), Positives = 384/924 (41%), Gaps = 144/924 (15%)
Query: 121 DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLK---EVLRENDLLRKDVEVKES 177
D + E + ++ A T L Q D+ L+ + K ++ R L D+++ +
Sbjct: 1012 DDLQMEEDKVNTLTKAKT---KLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQE 1068
Query: 178 KLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELR 237
+ N K + +LKK+ + KI + +Q++ + +Q I+ L++E+
Sbjct: 1069 STMDTEND-KQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIE 1127
Query: 238 IQRDLNQLFQQDSSSRTGE-PCVAELTEENFQRLHAEHERQAK---ELFLLRKTLEEMEL 293
+R ++ S + E ++E EE A+ E K E +R+ LEE L
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTL 1187
Query: 294 RIETQKQTLNARD-ESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQ 352
+ E L + +S+ +L E + S + E++ +E +M ++ L S +E
Sbjct: 1188 QHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEK------SELKMEINDLASNMET 1241
Query: 353 KEKENSMLREEMHRRFENAPDSAKTKA-----------------------LQTVIEMKDS 389
K + E+M R E+ KTK ++ KD+
Sbjct: 1242 VSKAKANF-EKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDA 1300
Query: 390 KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKI-------GQ 442
+S + RG + ++I+ LK T+ + ++ R ++ + +
Sbjct: 1301 MVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAE 1360
Query: 443 VKQELSRKDTELLALQTKLET---------------LTNQFSDSKQHIEVLKESLTAKEQ 487
+++ +S+ ++E+ +TK ET L + D+++H+E + + E+
Sbjct: 1361 LQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEK 1420
Query: 488 RAAILQTEVDALRLRLEEKETM---LNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERK 544
LQ EV+ L + +E L+KK + + E K + + +
Sbjct: 1421 TKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAE----------WKQKYEETQAE 1470
Query: 545 VNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI--- 601
+ QK+ +L +L + + +++L+ + N ++ L E +AE + I
Sbjct: 1471 LEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHEL 1530
Query: 602 ERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLS-----------EKEASLLDL 650
E++K+Q D ++ E Q ++ + L+ + K+ +Q +L+ EK+ L L
Sbjct: 1531 EKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQL 1590
Query: 651 KE-HASSLASSGLKKDSRLKTLEIALEQKKE---ECLKMESQLKKAHEAALEARASPE-- 704
K H + S D+ +++ AL KK+ + +ME QL A+ A EA +
Sbjct: 1591 KRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNT 1650
Query: 705 ---MSDRIQHLEREITRYKDESSKAQAEVDRLLEILK-EVEN-----EKNDKDKKIAELE 755
+ D HL+ I R +D+ + A V+R +++ EVE E+ ++ +K+AE E
Sbjct: 1651 QGILKDTQLHLDDAI-RGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQE 1709
Query: 756 --------RQVKDQNKKVANLKHKEQVE----KKKSAQMLEEARRREDNLNDS---SQQL 800
+ + QN + N K K + + + + +++EAR E+ + + +
Sbjct: 1710 LLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMM 1769
Query: 801 QDSLRKKDDRIEELEEALRESVQITAEREMVLAQ-EESARTNAEKQVEELLMAMEKVKQE 859
+ L+K+ D LE + Q + ++ L + E+ A +KQ+++L + +++ E
Sbjct: 1770 AEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESE 1829
Query: 860 LESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLEL 919
+ES ++ H RKH V E+ + +E+D +L L
Sbjct: 1830 VES--------------EQKHNVEAVKGLRKHERRVKELTYQ------TEEDRK-NILRL 1868
Query: 920 SSSKKKTQEEVAALKREKDRLVQQ 943
K Q +V A KR+ + +Q
Sbjct: 1869 QDLVDKLQTKVKAYKRQAEEAEEQ 1892
Score = 119 bits (299), Expect = 1e-26
Identities = 173/790 (21%), Positives = 338/790 (42%), Gaps = 96/790 (12%)
Query: 309 IKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRF 368
IK LL+ +++ A EE + LA+ E LE + +E + L+ ++
Sbjct: 840 IKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEA 899
Query: 369 ENAPDSAKT--KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQM 426
+ D+ + + ++T I++ ++KI + D EEEI N L+ ++R+ E +
Sbjct: 900 DALADAEERCDQLIKTKIQL-EAKIKEVTERAED-EEEI-----NAELTAKKRKLEDECS 952
Query: 427 EVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVL----KESL 482
E +K I ++ L++ + E A + K++ LT + + + I L K
Sbjct: 953 E--------LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1004
Query: 483 TAKEQRAAILQTEVDA----------LRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI- 531
A +Q LQ E D L ++++ E L ++ K D+ K G++
Sbjct: 1005 EAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLK 1064
Query: 532 -------------HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQA 578
L + L KE +++ LQ KIE+ Q +K++ L+ R++ L+
Sbjct: 1065 LAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEE 1124
Query: 579 DTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEID-NYKKDLKDLKEKVSLLQ 637
+ + E+ ++ R +E + E+ + +I+ N K++ + K + L +
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1184
Query: 638 GDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME-SQLKKAHEAA 696
L + + K+HA S+A G + DS L+ ++ LE++K E LKME + L E
Sbjct: 1185 STLQHEATAAALRKKHADSVAELGEQIDS-LQRVKQKLEKEKSE-LKMEINDLASNMETV 1242
Query: 697 LEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELER 756
+A+A + E+ +D+ S+ + + + ++ E+ +K + E R
Sbjct: 1243 SKAKA---------NFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSR 1293
Query: 757 QVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEE 816
Q+ +++ V+ L +Q Q +EE +R+ + + L +L+ + L E
Sbjct: 1294 QLDEKDAMVSQLSRGKQA----FTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLRE 1349
Query: 817 ALRESVQITAE--REMVLAQEESAR------TNAEKQVEELLMAMEKVKQELESMKAKLS 868
E + AE R M A E A+ T+A ++ EEL A +K+ Q L+ + +
Sbjct: 1350 QYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVE 1409
Query: 869 STQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI--ALLELSSSKKKT 926
+ A E L+ E + +V + A A+ +K N L E ++T
Sbjct: 1410 AVNSKCASLEKTKQRLQNEVEDLMIDV--ERSNAACIALDKKQRNFDKVLAEWKQKYEET 1467
Query: 927 QEEVAALKREKDRLVQQLKQQTQNRMKLMADNYED--DHFKSSHSNQTNHKPSPDQIIQP 984
Q E+ A ++E L +L + + + YE+ DH ++ N + + +
Sbjct: 1468 QAELEASQKESRSLSTELFK--------VKNAYEESLDHLETLKRENKNLQQEISDLTEQ 1519
Query: 985 LLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQL 1044
+ E ++ +L+ L H++ L +L++ +A+ E+E K+ R QL
Sbjct: 1520 IAEGGKHIHELEKVKKQLD---HEKSEL---------QTSLEEAEASLEHEEGKILRIQL 1567
Query: 1045 QDELEKGERD 1054
+ K E D
Sbjct: 1568 ELNQVKSEID 1577
Score = 99.0 bits (245), Expect = 2e-20
Identities = 131/625 (20%), Positives = 267/625 (42%), Gaps = 96/625 (15%)
Query: 137 STVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKK 196
ST+ H+L+ AR + + L+ Q +E L++ + S+++ +T ++
Sbjct: 1331 STLAHALQSARHDCDL-LREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEE 1389
Query: 197 ERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGE 256
+K A ++ +E V + ++ T Q LQ+E+ DL R+
Sbjct: 1390 LEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVE---DL-----MIDVERSNA 1441
Query: 257 PCVA-ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK-QTLNARDESIKKLLE 314
C+A + + NF ++ AE +++ +E + ++ + T+ + NA +ES+ L E
Sbjct: 1442 ACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHL-E 1500
Query: 315 MLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDS 374
L+ + + + +E + T ++AE H+H LE + +Q + E S L+ + E + +
Sbjct: 1501 TLKRENKNLQ--QEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEA-EASLEH 1557
Query: 375 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE----EMKQMEVYR 430
+ K L+ +E+ K S ++R + + +EE+ LK N E + E++
Sbjct: 1558 EEGKILRIQLELNQVK-SEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDAL 1616
Query: 431 SHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEV-------LKESLT 483
K M+ + +++ +L+ + + L D++ H++ LKE L
Sbjct: 1617 RIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLA 1676
Query: 484 AKEQRAAILQTEVDALRLRLEEKE-------------------------TMLNKKTKQIQ 518
E+RA ++Q EV+ LR LE E +++N K K
Sbjct: 1677 MVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLET 1736
Query: 519 DM----------------AEEKGTQA--------GEIHDLKDMLDVKERKVNVLQKKIEN 554
D+ AEEK +A E+ +D ER +++ +++
Sbjct: 1737 DISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKD 1796
Query: 555 LQEQLRDKE--------KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKE 606
LQ +L + E KQ+ L+ RV+ L+++ + + L + ER ++ L
Sbjct: 1797 LQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTY 1856
Query: 607 QRDRDER----------EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASS 656
Q + D + + Q ++ YK+ ++ +E+ ++ + + L + KE A
Sbjct: 1857 QTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERA-D 1915
Query: 657 LASSGLKKDSRLKTLEIALEQKKEE 681
+A S + K R+K+ E+ + EE
Sbjct: 1916 IAESQVNK-LRVKSREVHTKVISEE 1939
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 140 bits (352), Expect = 9e-33
Identities = 205/947 (21%), Positives = 400/947 (42%), Gaps = 94/947 (9%)
Query: 163 RENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEEN 222
+E + L+++ ++ +L ++ EL++ER + + ++ ++Q R QEE
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR-EQQLRRKQEEE 313
Query: 223 QHMQMTIQALQDELRIQRD--LNQLFQQDSSSRTGEPCVAELTEENFQ---RLHAEHERQ 277
+ Q + Q E R Q++ Q +++ R + E EE + R E ER+
Sbjct: 314 RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373
Query: 278 AKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLA 337
++L ++ E +LR E Q + R++ +++ ++ + + L + ++ RR
Sbjct: 374 EQQLRREQQLRREQQLRREQQLR----REQQLRREQQLRREQQLRREQQLRREQQLRREQ 429
Query: 338 EAEMHVHHLESLLEQKEKENSMLREEMHRR--FENAPDSAKTKALQTVIEMK-DSKISSM 394
E E H E EQ+ +E + RE+ RR + ++ + + + ++K D +
Sbjct: 430 EEERH----EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR 485
Query: 395 ERGLRDLEEEI--------QMLKSNGALSTEER----EEEMKQMEVYRSHSKFMKNKIGQ 442
ER L+ EEE Q L+ E+R EEE + + RS + + + +
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER 545
Query: 443 VKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLR 502
+Q L R++ + L + + + L + + + ++LK ++QR Q E RL+
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRD--QLLKREEERRQQRLKREQEERLEQRLK 603
Query: 503 LEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDK 562
EE E + ++ ++ + EE + + L + +ER+ L+++ + +EQ +
Sbjct: 604 REEVERLEQEERREQRLKREEPEEERRQ--QLLKSEEQEERRQQQLRREQQERREQRLKR 661
Query: 563 EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDN- 621
E++ L++R+K + E A E+E+ ER+K + + + + + E D
Sbjct: 662 EEEEERLEQRLKREHEEERREQ------ELAEEEQEQARERIKSRIPKWQWQLESEADAR 715
Query: 622 ----YKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQ 677
Y + K ++ Q + + S L +E + ++ R T + E+
Sbjct: 716 QSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775
Query: 678 KKE---ECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLL 734
K E + L L++ E L A + R E E K++ + + E ++ L
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEE----KEQRRRQRREREKEL 831
Query: 735 EILKEVEN-EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNL 793
+ L+E E ++ ++ +++ E E +++ ++ + +EQ +K LEE R+R +
Sbjct: 832 QFLEEEEQLQRRERAQQLQEEEDGLQEDQER---RRSQEQRRDQKWRWQLEEERKRRRHT 888
Query: 794 NDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQV---EELL 850
+ LQ+ LRK+ ++E EE L+ ERE QE+ + E+Q+ EE L
Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQRE-----EREKRRRQEQERQYREEEQLQQEEEQL 943
Query: 851 MAMEKVK---QELESMKAKLSSTQQS----LAEKETHLTNLRAERRKHLEEVLEMKQEAL 903
+ E+ K QE E K QQ L E+ E++ EE L+ ++E L
Sbjct: 944 LREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL 1003
Query: 904 LAAISEKDANIALLELSSSKKKTQEEVAALKRE--KDRLVQQLKQQTQNRMKLMADNYED 961
L EK K + Q+E L RE + R +Q+ ++Q + +L ++
Sbjct: 1004 LREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQ----QE 1059
Query: 962 DHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPA 1021
+ +T + ++ + EL Q +L LR
Sbjct: 1060 EEQLLGEERETRRRQELERQYRKEEELQQEEEQL------------------LREEPEKR 1101
Query: 1022 SYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQ 1068
+ Q E ELQ+ L++E EK R E Q +QQ
Sbjct: 1102 RRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ 1148
Score = 125 bits (313), Expect = 3e-28
Identities = 170/787 (21%), Positives = 346/787 (43%), Gaps = 66/787 (8%)
Query: 195 KKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRT 254
++ER LR +E + ++++ +EE + + + + EL+ + QL +++ + +
Sbjct: 793 QRERQLRAEERQQR---EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQL 849
Query: 255 GEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLE 314
E + +E+ +R ++ +R+ ++ R LEE R A E ++K +
Sbjct: 850 QEE--EDGLQEDQERRRSQEQRRDQKW---RWQLEEERKRRRHTLYAKPALQEQLRKEQQ 904
Query: 315 MLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDS 374
+LQ + + E+ E+ RR + + + E L+Q+E++ E RR E
Sbjct: 905 LLQEE--EEELQREEREKRRR--QEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960
Query: 375 AKTKALQTVIEM----KDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYR 430
K K LQ E + K ER + EEE ++ + L EERE+ +Q E R
Sbjct: 961 RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE-ELQQEEEQLLREEREKRRRQ-EWER 1018
Query: 431 SHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAA 490
+ K K+++ Q +++L R++ E LQ + + ++ ++L E + ++
Sbjct: 1019 QYRK--KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 491 ILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQK 550
Q + L+ EE++ + + K+ + E + + E+ ++ L +ER+ ++
Sbjct: 1077 ERQYRKEE-ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE----KR 1131
Query: 551 KIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEA-LAEKERTIERLKEQRD 609
+ + L+ Q R++E+ ++ ++ + EE L ++E + R ++++
Sbjct: 1132 RRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR 1191
Query: 610 RDEREKQ----EEIDNYKKD--LKDLKEKVSLLQGDLSEKEASLLDLK--------EHAS 655
R ERE+Q EE+ K+ +D ++ L EKE ++ D K E
Sbjct: 1192 RQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFR 1251
Query: 656 SLASSGLKKDSRLKTLEIALEQKKEECLKMES---QLKKAH---EAALEARASPEMS--D 707
L S L+ + L+ L +++E + E Q + H E LE E D
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311
Query: 708 RIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVAN 767
R E+++ R + E + + E DR K E E+ ++++ L RQ +D+ +
Sbjct: 1312 RKSQEEKQLLREEREEKRRRQETDR-----KFREEEQLLQEREEQPLRRQERDRKFREEE 1366
Query: 768 LKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAE 827
L+H+EQ K + + RE QQL+ R++ R + + E Q++ +
Sbjct: 1367 LRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQ 1426
Query: 828 REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 887
+EE + +++ + L ++++QE K +Q L E+E + +
Sbjct: 1427 ERDRKFREEEQQVRRQERERKFLEEEQQLRQE---RHRKFREEEQLLQEREEQQLHRQER 1483
Query: 888 RRKHLEEVLEMKQEALLAAISEKDANIALLELSS---SKKKTQEEVAALKREKDRLVQQL 944
RK LEE +++++ E+D EL S +K +EE ++++ R Q
Sbjct: 1484 DRKFLEEEQQLRRQ-------ERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQE 1536
Query: 945 KQQTQNR 951
+QQ + +
Sbjct: 1537 EQQLRRQ 1543
Score = 117 bits (293), Expect = 6e-26
Identities = 175/821 (21%), Positives = 357/821 (43%), Gaps = 94/821 (11%)
Query: 144 RQARDNTIMDLQTQLKEVLR--ENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALR 201
R+ R ++ Q + +E L+ E LLR++ E + + + + ++E+ LR
Sbjct: 1068 RETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ--ERERQCREEEELQQEEEQLLR 1125
Query: 202 KD-EASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVA 260
++ E + + QYR +E Q + ++ + E R +++L + ++++ + E
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLRE-EPEKRRRQELERQYREEEELQQEEE--- 1181
Query: 261 ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL---EMLQ 317
+L E ++ E ERQ +E L++ + R E Q+ L + E K+ +
Sbjct: 1182 QLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY 1241
Query: 318 SKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKT 377
KG + + + R +++ + HL L EQ+E++ R +R + P+ +
Sbjct: 1242 CKGRENEQFRQLEDSQLRDRQSQQDLQHL--LGEQQERDREQERRRWQQRDRHFPEEEQL 1299
Query: 378 KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMK 437
+ E K++K R R +EE Q+L+ EEREE+ ++ E R KF
Sbjct: 1300 ERE----EQKEAK-----RRDRKSQEEKQLLR-------EEREEKRRRQETDR---KF-- 1338
Query: 438 NKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVD 497
++ E L + + + L Q D K +E L +EQ L+ E
Sbjct: 1339 ------------REEEQLLQEREEQPLRRQERDRKFR----EEELRHQEQGRKFLEEEQ- 1381
Query: 498 ALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE 557
RLR +E+E K+ +Q++ +E+ Q + D K + ++ +K ++
Sbjct: 1382 --RLRRQERERKFLKEEQQLR--CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437
Query: 558 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQE 617
Q+R +E++ L+E + Q EE L ++ + +++RDR E+++
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFRE-----EEQLLQEREEQQLHRQERDRKFLEEEQ 1492
Query: 618 EIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE--HASSLASSGLKKDSRLKTLEIAL 675
++ ++D K ++++ E E L+ ++ H L+++ +L+ E
Sbjct: 1493 QLRRQERDRKFREQELRS-----QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547
Query: 676 EQKKEECLKM--ESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRL 733
+++++ K E QL++ E E + S + DR LE + R +++ K + +L
Sbjct: 1548 QRRQDRDRKFREEEQLRQERE---EQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQL 1604
Query: 734 L--EILKEVENEKNDKDKKIAEL-----ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 786
E +++ E++ K ++ +L E+Q+ Q + L+ + Q+ +++ Q L
Sbjct: 1605 RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHD 1664
Query: 787 R----RREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 842
R R E+ L ++ Q +++D + E E+ LR ERE QEE
Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ-----ERERKFLQEEQQLRRQ 1719
Query: 843 EKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEA 902
E +E E+++QE E + + + + E+E ++ + E + ++E
Sbjct: 1720 E--LERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEE 1777
Query: 903 LLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQ 943
L E+ L S +K +EE +RE+ +L Q
Sbjct: 1778 QLRQEREEQ---QLRSQESDRKFREEEQLRQEREEQQLRPQ 1815
Score = 114 bits (286), Expect = 4e-25
Identities = 186/880 (21%), Positives = 369/880 (41%), Gaps = 117/880 (13%)
Query: 212 KEQYRVVQEENQHMQ--MTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQR 269
+E+ R +E+ Q + T + +E +R+L +L R G + E R
Sbjct: 183 REERRAEEEQLQSCKGHETEEFPDEEQLRRRELLEL------RRKGREEKQQQRRERQDR 236
Query: 270 LHAEHERQA--KELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATE 327
+ E E + K +LRK E+++ +++ L +E ++K L+ + L + E
Sbjct: 237 VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK----LERQELRRERQE 292
Query: 328 EDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMK 387
E+ ++ R E ++ E EQ+E+ RE+ RR + + Q E +
Sbjct: 293 EEQQQQRLRREQQLRRKQEEERREQQEER----REQQERR----EQQEERREQQLRREQE 344
Query: 388 DSKISSMERGLRDLEEEIQMLKSNGALSTEE---REEEMKQMEVYRSHSKFMKNKIGQVK 444
+ + + R + E Q+ + E+ RE+++++ + R + + + + +
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404
Query: 445 QELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 504
Q+L R+ Q + E + + ++H + K +EQR Q E R E
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQ--KHEQERREQRLKREQEERRDWLKREE 462
Query: 505 EKETMLNKKTKQ--IQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDK 562
E E ++ KQ +D EE+ + ++ + ++ + +ER+ L+++ E +EQ +
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEE-EERREQQERREQQLRREQEERREQRLKR 521
Query: 563 EKQMSSLKERVKSLQ----ADTTNTDTALTTLEEALAEKERTIERLK-EQRDRDEREKQE 617
+++ L++R++S Q + L EE E+ER +RLK EQ +R ++ +
Sbjct: 522 QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKR 581
Query: 618 EIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQ 677
E + ++ LK +E+ L+ L +E L+ +E +++ RLK E E+
Sbjct: 582 EEERRQQRLK--REQEERLEQRLKREEVERLEQEE----------RREQRLKR-EEPEEE 628
Query: 678 KKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEIL 737
++++ LK E Q ++ R Q L RE +++ K + E +RL + L
Sbjct: 629 RRQQLLKSEEQEER----------------RQQQLRREQQERREQRLKREEEEERLEQRL 672
Query: 738 KEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSA-QMLEEARRREDNLNDS 796
K E+E+ +++++AE E++ + K K + Q+E + A Q +R R+
Sbjct: 673 KR-EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR 731
Query: 797 SQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKV 856
Q+ ++ R+++ ++ EE ER QEE R + Q +
Sbjct: 732 RQEQEEKRRRRESELQWQEE----------ERAHRQQQEEEQRRDFTWQWQ--------A 773
Query: 857 KQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL 916
+++ E + +LS+ ++E LRAE R+ E+
Sbjct: 774 EEKSERGRQRLSARPPLREQRE---RQLRAEERQQREQRF-------------------- 810
Query: 917 LELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKP 976
L ++K Q +REK+ + ++Q Q R + E+D + + + +
Sbjct: 811 --LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQ 868
Query: 977 SPDQIIQPLLELDQNRSKLKLY--------IGHLTTLCHDRDPLILRGLTPPASYNLDDD 1028
DQ + LE ++ R + LY + L + + + R +
Sbjct: 869 RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER 928
Query: 1029 QAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQ 1068
Q E +LQ+ L++E EK R E Q + LQQ
Sbjct: 929 QYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ 968
Score = 113 bits (282), Expect = 1e-24
Identities = 147/717 (20%), Positives = 308/717 (42%), Gaps = 57/717 (7%)
Query: 163 RENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEEN 222
RE + L++ + + + +K W PE KE A+R ++ EQ+R +++
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPE--KENAVRDNKVYCKGRENEQFRQLEDSQ 1257
Query: 223 QHMQMTIQALQ------------DELRIQRDLNQLFQQDSSSRTGEPCVAEL----TEEN 266
+ + Q LQ E R + ++ F ++ E A+ ++E
Sbjct: 1258 LRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE 1317
Query: 267 FQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKAT 326
Q L E E + + RK EE +L E ++Q L ++ K E L+ + K
Sbjct: 1318 KQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL 1377
Query: 327 EEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEM 386
EE+ +R RR E E E L +E+E LR++ R+F +
Sbjct: 1378 EEE-QRLRR-QERERKFLKEEQQLRCQEREQQ-LRQDRDRKFREEEQQLSRQERDRKFRE 1434
Query: 387 KDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQE 446
++ ++ ER + LEEE Q L+ E E+ +++ E + H + K + +Q+
Sbjct: 1435 EEQQVRRQERERKFLEEE-QQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493
Query: 447 LSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRL-RLEE 505
L R++ + + +L + + ++ ++ L ++++ LQ E R R ++
Sbjct: 1494 LRRQERDRKFREQELRS-----QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQ 1548
Query: 506 KETMLNKKTKQIQDMAEEKGTQ--AGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKE 563
+ ++K ++ + + +E+ Q + + D K L+ ++ + ++K ++QLR +E
Sbjct: 1549 RRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQE 1608
Query: 564 KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYK 623
Q +ER + + D + L EE ++ + E+ + R+++E+ +
Sbjct: 1609 GQQQLRQERDRKFRED----EQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHD 1664
Query: 624 KDLKDLKEKVSLLQGDLSEKEASLLDLK--EHASSLASSG-----LKKDSRLKTLEIALE 676
+D K +E+ L +G+ + D K E L L+++ +L+ E+ +
Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERK 1724
Query: 677 QKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEI 736
++EE L+ E++ ++ + E R + E+++ R E + E ++L +
Sbjct: 1725 FREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR--QERDRKFREEEQLRQE 1782
Query: 737 LKEVENEKNDKDKKIAELER--------QVKDQNKKVANLKHKEQVEKKKSAQMLEEARR 788
+E + + D+K E E+ Q++ Q + +EQ++ ++ Q L + R
Sbjct: 1783 REEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERD 1842
Query: 789 REDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQ 845
R+ + + S R++ + +E E+ R+ ERE L +E R E+Q
Sbjct: 1843 RQYRAEEQFATQEKSRREEQELWQEEEQKRRQ------ERERKLREEHIRRQQKEEQ 1893
Score = 109 bits (272), Expect = 2e-23
Identities = 147/740 (19%), Positives = 315/740 (42%), Gaps = 126/740 (17%)
Query: 347 ESLLEQKEKENSMLR-EEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEI 405
ESLL+ + +E R E R+ E P + + Q ER L + EE+
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQ-----------EQERELAEGEEQS 155
Query: 406 QMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLT 465
+ + E+R+ + + E++R ++ QE + E LQ+ T
Sbjct: 156 EKQER-----LEQRDRQRRDEELWRQRQEW---------QEREERRAEEEQLQSCKGHET 201
Query: 466 NQFSDSKQ--HIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE-----TMLNKKTKQIQ 518
+F D +Q E+L+ +E++ + D + EEKE T+L K+ +++Q
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 519 D---------MAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSL 569
+ EE+ + E +L+ +E++ L+++ + ++Q ++ +Q
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 570 KERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDL 629
+E+ + + + L +E E++ E+ +E+R++ R +QEE
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE----------- 370
Query: 630 KEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQL 689
E+ L ++ L+++ +L+ + + ++E+ L+ E QL
Sbjct: 371 ------------ERREQQLRREQQ--------LRREQQLRREQ---QLRREQQLRREQQL 407
Query: 690 KKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDK 749
++ + E + E Q L RE ++E + + E +R + LK + E+ D K
Sbjct: 408 RREQQLRREQQLRRE-----QQLRRE---QEEERHEQKHEQERREQRLKREQEERRDWLK 459
Query: 750 KIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDD 809
+ E ER +Q ++ LK ++ E+++ LEE RRE Q ++ +++
Sbjct: 460 REEETERH--EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517
Query: 810 RIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSS 869
R++ EE R ++ +E+++ QEE R K+ EE + E+ +Q L+ + +
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEE-RREQLLKREEEKRLEQERREQRLKREQEE-RR 575
Query: 870 TQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEE 929
Q E+E L+ E+ + LE+ L+ ++ + + +++ L+ +++ +++
Sbjct: 576 DQLLKREEERRQQRLKREQEERLEQRLKREE---VERLEQEERREQRLKREEPEEERRQQ 632
Query: 930 VAALKREKDRLVQQLKQQTQNRMKLMADNYEDD-----HFKSSHSNQTNHKPSPDQIIQP 984
+ + +++R QQL+++ Q R + E++ K H + + ++
Sbjct: 633 LLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE---- 688
Query: 985 LLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQ- 1043
E +Q R ++K I P + L+ + A ++++ R Q
Sbjct: 689 --EQEQARERIKSRI-------------------PKWQWQLESEADARQSKVYSRPRKQE 727
Query: 1044 ----LQDELEKGERDNAELQ 1059
Q++ EK R +ELQ
Sbjct: 728 GQRRRQEQEEKRRRRESELQ 747
Score = 84.0 bits (206), Expect = 7e-16
Identities = 100/512 (19%), Positives = 213/512 (41%), Gaps = 71/512 (13%)
Query: 504 EEKETMLNKKTKQIQDMAEEKGTQAGEIHD----------LKDMLDVKERKV------NV 547
EEK + K +QD +E+ + E D + +ER++ +
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 548 LQKKIENLQEQLRDKE--KQMSSLKER------------VKSLQADTTNTDTALTTLEEA 593
Q+++E Q RD+E +Q +ER K + + + L E
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216
Query: 594 LAEKERTIERLKEQRDRDEREKQEEID-NYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE 652
++ E+ +++R+R +R QEE + ++K L+++ LQ + +++ L + +E
Sbjct: 217 ELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEE 276
Query: 653 HASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHL 712
L L+++ + E+++++ L+ E QL++ E E R E Q
Sbjct: 277 QLRKLERQELRRERQ-------EEEQQQQRLRREQQLRRKQEE--ERREQQEERREQQER 327
Query: 713 EREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKE 772
+ +++ + + E R ++ +E E E+ ++ + + E + + Q ++ L+ ++
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387
Query: 773 QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVL 832
Q+ +++ + ++ RR + + + + LR++ E EE E RE L
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447
Query: 833 AQEESARTNAEKQVEEL-LMAMEKVKQELES----------MKAKLSSTQQSLAEKETHL 881
+E+ R + K+ EE E+ KQ+L+ +K + ++ +E L
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL 507
Query: 882 TNLRAERR--------------------KHLEEVLEMKQEALLAAISEKDANIALLELSS 921
+ ERR + L E ++E LL EK E
Sbjct: 508 RREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRL 567
Query: 922 SKKKTQEEVAALKREKDRLVQQLKQQTQNRMK 953
+++ + LKRE++R Q+LK++ + R++
Sbjct: 568 KREQEERRDQLLKREEERRQQRLKREQEERLE 599
Score = 58.9 bits (141), Expect = 2e-08
Identities = 68/328 (20%), Positives = 146/328 (44%), Gaps = 30/328 (9%)
Query: 644 EASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLK--KAHEAALEARA 701
+A+ LD ++ A L +D R + + E + + + Q + K E E
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150
Query: 702 SPEMSDRIQHLEREITRYKDES-----------SKAQAEVDRLLEI----LKEVENEKND 746
E S++ + LE+ + +DE + +AE ++L +E +E+
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210
Query: 747 KDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRK 806
+ +++ EL R+ +++ ++ + +E+ ++ + +E R+RE L ++LQ+ +
Sbjct: 211 RRRELLELRRKGREEKQQ----QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266
Query: 807 KDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAK 866
+ ++E EE LR+ + RE +++ R E+Q+ E+ +++ E + +
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR--KQEEERREQQEERREQ 324
Query: 867 LSSTQQSLAEKETHLTNLRAERRKH--LEEVLEMKQEALLAAISEKDANIALLELSSSKK 924
+Q +E L + ERR+ E E ++E L E++ L +
Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384
Query: 925 KTQEEVAALKREKD-RLVQQLKQQTQNR 951
+ Q+ L+RE+ R QQL+++ Q R
Sbjct: 385 REQQ----LRREQQLRREQQLRREQQLR 408
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 139 bits (351), Expect = 1e-32
Identities = 186/850 (21%), Positives = 367/850 (43%), Gaps = 102/850 (12%)
Query: 142 SLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALR 201
+L++A + DLQ + +V N L + V++ E ++ S++ + ERA R
Sbjct: 1000 ALQEAHQQALDDLQVEEDKV---NSLSKSKVKL-EQQVDDLEGSLEQEKKVRMDLERAKR 1055
Query: 202 KDEAS-KITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQL-------FQQDSSSR 253
K E K+T Q ++ EN +Q+ + + E I + +++ Q +
Sbjct: 1056 KLEGDLKLT----QESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLK 1111
Query: 254 TGEPCVAELTEENFQRLHAEHERQAKELFL---LRKTLEEMELRIE-------TQKQTLN 303
+ + EL EE L AE +AK L L + LEE+ R+E Q +
Sbjct: 1112 ENQARIEELEEE----LEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK 1167
Query: 304 ARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEM--HVHHLESLLEQKEKENSMLR 361
R+ +K+ L+ L +AT + + AE+ + +L+ + ++ EKE S +
Sbjct: 1168 KREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1227
Query: 362 EEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE 421
E+ N K KA + + R L D E ++ + EE
Sbjct: 1228 LELDDVTSNMEQIIKAKA----------NLEKVSRTLEDQANEYRV----------KLEE 1267
Query: 422 EMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES 481
+ + + + ++ + G++ ++L K+ + L + T Q D K+ +E E
Sbjct: 1268 AQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLE---EE 1324
Query: 482 LTAKEQRAAILQT---EVDALRLRLEEK-------ETMLNKKTKQIQDMAEEKGTQAGEI 531
AK A LQ+ + D LR + EE+ + +L+K ++ + T A I
Sbjct: 1325 GKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDA--I 1382
Query: 532 HDLKDMLDVKERKVNVLQ---KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALT 588
+++ + K++ LQ + +E + + EK L+ ++ L D ++ A
Sbjct: 1383 QRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA 1442
Query: 589 TLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASL- 647
L++ K+R +++ + + E Q E+++ +K+ + L ++ L+ E L
Sbjct: 1443 ALDK----KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 1498
Query: 648 ------LDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA-----HEAA 696
+L+E S L + + LE +Q + E L+++S L++A HE
Sbjct: 1499 TFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEG 1558
Query: 697 LEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILK-EVENEKNDKDKKIAELE 755
RA E + +ER++ +E +A+ R+++ L+ ++ E +++ + +
Sbjct: 1559 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKK 1618
Query: 756 RQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELE 815
+ D N+ L H ++ +A+ ++ + + L D+ QL D++R DD E +
Sbjct: 1619 KMEGDLNEMEIQLSHANRM----AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIA 1674
Query: 816 EALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLA 875
R + + AE E + A E + + +EL+ E+V Q L S L + ++ +
Sbjct: 1675 IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERV-QLLHSQNTSLINQKKKM- 1732
Query: 876 EKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKR 935
E+ LT L++E + ++E +++A A DA + EL KK Q+ A L+R
Sbjct: 1733 --ESDLTQLQSEVEEAVQECRNAEEKAKKAI---TDAAMMAEEL----KKEQDTSAHLER 1783
Query: 936 EKDRLVQQLK 945
K + Q +K
Sbjct: 1784 MKKNMEQTIK 1793
Score = 131 bits (329), Expect = 4e-30
Identities = 190/942 (20%), Positives = 404/942 (42%), Gaps = 119/942 (12%)
Query: 157 QLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKK--ERALRKDEASKITIWKE- 213
++KE L +++ RK++E K L N ++ E + R D+ K I E
Sbjct: 860 RIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEA 919
Query: 214 -----QYRVVQEENQHMQMTIQA--LQDEL-RIQRDLNQL----FQQDSSSRTGEPCVAE 261
R+ EE + ++T + L+DE +++D++ L + + E V
Sbjct: 920 KVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 979
Query: 262 LTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKL---LEMLQS 318
LTEE L + KE L++ ++ ++ ++ +N+ +S KL ++ L+
Sbjct: 980 LTEE-MAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEG 1038
Query: 319 KGLSAKATEEDHERTRRLAEAEMHVHH------------LESLLEQKE----KENSMLRE 362
K D ER +R E ++ + LE L++KE ++NS + +
Sbjct: 1039 SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIED 1098
Query: 363 E----MHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQML-----KSNGA 413
E + + + + A+ + L+ +E + + + +E+ DL E++ + ++ GA
Sbjct: 1099 EQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGA 1158
Query: 414 LSTE-----EREEEMKQME--------VYRSHSKFMKNKIGQVKQELSRKDTELLALQTK 460
S + +RE E ++M + + + ++ K EL + L ++ K
Sbjct: 1159 TSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK 1218
Query: 461 LETLTNQFS----DSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQ 516
LE ++F D ++E + ++ E+ + L+ + + R++LEE + LN T Q
Sbjct: 1219 LEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ 1278
Query: 517 IQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSL 576
+ E G A ++ + + ++ R +++E+L+ QL ++ K ++L ++S
Sbjct: 1279 RAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSA 1338
Query: 577 QADTTNTDTALTTLEEALAEKERTIERLKEQ-------RDRDEREKQEEIDNYKKDL--- 626
+ D EA AE +R + + + + D ++ EE++ KK L
Sbjct: 1339 RHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1398
Query: 627 -KDLKEKVSLLQGDLSEKEASLLDLK----------EHASSLASSGLKKDSRLKTLEIAL 675
+D +E V + S E + L+ E +++ A++ KK +
Sbjct: 1399 LQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEW 1458
Query: 676 EQKKEECL-KMESQLKKAHEAALEA-RASPEMSDRIQHLE----------REITRYKDES 723
+QK EE ++ES K+A + E + + ++HLE EI+ ++
Sbjct: 1459 KQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1518
Query: 724 SKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV--ANLKH---KEQVEKK- 777
+ V L ++ K++E EK + + E E ++ + K+ A L+ K ++E+K
Sbjct: 1519 GEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 1578
Query: 778 -KSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEE 836
+ + +E+A+R + DS Q D+ + + + +++ + + E E+ L+
Sbjct: 1579 AEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLN---EMEIQLSHAN 1635
Query: 837 SARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLA--EKETHLTNLRAERRKHLEE 894
A+KQV+ L ++ + +L+ ++++A E+ +L E + + E
Sbjct: 1636 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1695
Query: 895 VLEMKQEALLAAISEKDANIALLE-----LSSSKKKTQEEVAALKREKDRLVQQLKQQTQ 949
E ++ + E + LL L + KKK + ++ L+ E + VQ+ + +
Sbjct: 1696 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEE 1755
Query: 950 NRMK------LMADNYEDDHFKSSHSNQTNHKPSPDQIIQPL 985
K +MA+ + + S+H + K + +Q I+ L
Sbjct: 1756 KAKKAITDAAMMAEELKKEQDTSAHLERM--KKNMEQTIKDL 1795
Score = 126 bits (316), Expect = 1e-28
Identities = 193/939 (20%), Positives = 405/939 (43%), Gaps = 147/939 (15%)
Query: 191 SPELKKERALRKDEASKI--TIWKEQYR----------VVQEENQHMQMTIQALQDEL-- 236
S E +KE A K+E +I T+ K + R ++QE+N +Q+ +QA QD L
Sbjct: 844 SAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKND-LQLQVQAEQDNLND 902
Query: 237 ---RIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMEL 293
R + + Q ++ + + + E N + L A+ + E L+K ++++EL
Sbjct: 903 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE-LTAKKRKLEDECSELKKDIDDLEL 961
Query: 294 RIETQKQTLNARDESIKKLL-EMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQ 352
+ ++ +A + +K L EM + AK T+E + A E H L+ L +
Sbjct: 962 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE------KKALQEAHQQALDDLQVE 1015
Query: 353 KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNG 412
++K NS+ + ++ + E D L+ +E + +ER R LE ++++ +
Sbjct: 1016 EDKVNSLSKSKV--KLEQQVDD-----LEGSLEQEKKVRMDLERAKRKLEGDLKLTQE-- 1066
Query: 413 ALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSK 472
S + E + Q+E K K + +Q +D ++LALQ L + +++
Sbjct: 1067 --SIMDLENDKLQLE-----EKLKKKEFDINQQNSKIEDEQVLALQ-----LQKKLKENQ 1114
Query: 473 QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 532
IE L+E L A+ R ++E+ + L+++ ++I + EE G
Sbjct: 1115 ARIEELEEELEAER-----------TARAKVEKLRSDLSRELEEISERLEEAGGATSV-- 1161
Query: 533 DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 592
+++ +++ QK +L+E E ++L+++ AD+
Sbjct: 1162 ----QIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK----HADSV----------A 1203
Query: 593 ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDL------KEKVS-LLQGDLSEKEA 645
L E+ ++R+K++ ++++ E + E+D+ +++ + EKVS L+ +E
Sbjct: 1204 ELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRV 1263
Query: 646 SLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEM 705
L E A + + ++L+T L ++ EE + SQL + + + +M
Sbjct: 1264 KL----EEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRG-----KLSYTQQM 1314
Query: 706 SDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV 765
D + LE E + K+ + A ++L+E E+ + AEL+R + N +V
Sbjct: 1315 EDLKRQLEEE-GKAKNALAHALQSARHDCDLLREQYEEETEAK---AELQRVLSKANSEV 1370
Query: 766 ANLKHKEQVE-----------KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 814
A + K + + KKK AQ L++A + +N L+ + + + IE+L
Sbjct: 1371 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1430
Query: 815 EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 874
+ S A + + +++ EE +E ++E S+ +L + +
Sbjct: 1431 MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAY 1490
Query: 875 AEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS-------EKDANIALLELSSSKKKTQ 927
E HL + E + EE+ ++ ++ + K + LEL S+ +
Sbjct: 1491 EESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSA---LE 1547
Query: 928 EEVAALKREKDRLVQ------QLKQQTQNRMKLMADNYED---DHFKSSHSNQTN---HK 975
E A+L+ E+ ++++ Q+K + + ++ + E +H + S QT+
Sbjct: 1548 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAET 1607
Query: 976 PSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLI--LRGLTPPASYNLDDDQAAWE 1033
S +++++ +++ + +++++ + H + + + L+ L LDD A
Sbjct: 1608 RSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRA-- 1665
Query: 1034 NELQKMTRGQLQDELEKGERDN----AELQEFANAILQQ 1068
L++ + ER N AEL+E A+++Q
Sbjct: 1666 -------NDDLKENIAIVERRNNLLQAELEEL-RAVVEQ 1696
Score = 124 bits (312), Expect = 4e-28
Identities = 170/846 (20%), Positives = 354/846 (41%), Gaps = 117/846 (13%)
Query: 136 ASTVPHSLRQARDNTIMDLQTQLKEVLRENDL----LRKDVEVKESKLSSSMNSIKTFWS 191
A++V + + R+ ++ L+E +++ LRK ++L +++++
Sbjct: 1158 ATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV-K 1216
Query: 192 PELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSS 251
+L+KE++ K E +T EQ + + + T++ +E R++ + Q D +
Sbjct: 1217 QKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFT 1276
Query: 252 SRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKK 311
++ A+L EN + L + LEE E I + + + ++
Sbjct: 1277 TQR-----AKLQTENGE---------------LARQLEEKEALISQLTRGKLSYTQQMED 1316
Query: 312 LLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENA 371
L L+ +G + A LA A H LL ++ +E + + E+ R A
Sbjct: 1317 LKRQLEEEGKAKNA----------LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKA 1366
Query: 372 PDSA-------KTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMK 424
+T A+Q E++++K +R L+D EE ++ + N S+ E+ +
Sbjct: 1367 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQR-LQDAEEAVEAV--NAKCSSLEKTKHRL 1423
Query: 425 QMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA 484
Q N+I + ++ R + AL K ++ KQ E + L +
Sbjct: 1424 Q------------NEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1471
Query: 485 KEQRAAILQTEVDALRLRLEEKETML------NKKTKQ-IQDMAEEKGTQAGEIHDLKDM 537
++ A L TE+ L+ EE L NK ++ I D+ E+ G +H+L+ +
Sbjct: 1472 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKV 1531
Query: 538 LDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEK 597
E + LQ +E + L +E ++ + ++A+ +E LAEK
Sbjct: 1532 RKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAE----------IERKLAEK 1581
Query: 598 ERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSL 657
+ +E+ K R Q +D + ++ ++GDL+E E L HA+ +
Sbjct: 1582 DEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQL----SHANRM 1637
Query: 658 ASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARAS------PEMSDRIQH 711
A+ K+ L++L + + ++ ++ LK+ + A +E R + E+ ++
Sbjct: 1638 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE-NIAIVERRNNLLQAELEELRAVVEQ 1696
Query: 712 LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 771
ER + E + V L + N+K + + +L+ +V++ ++ N + K
Sbjct: 1697 TERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEK 1756
Query: 772 EQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMV 831
+ +A M EE ++ +D +S L+ + + I++L+ L E+ QI
Sbjct: 1757 AKKAITDAAMMAEELKKEQD----TSAHLERMKKNMEQTIKDLQHRLDEAEQI------- 1805
Query: 832 LAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE---- 887
A +KQ+++L + +++ ELE+ + + + + + + + E + L +
Sbjct: 1806 ------ALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEED 1859
Query: 888 -----RRKHLEEVLEMKQEAL--LAAISEKDANIALLELSSSKKKTQEEVAALKREKDRL 940
R + L + L++K +A A +E+ AN L S +K Q E+ + D
Sbjct: 1860 KKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNL----SKFRKVQHELDEAEERADIA 1915
Query: 941 VQQLKQ 946
Q+ +
Sbjct: 1916 ESQVNK 1921
Score = 116 bits (291), Expect = 1e-25
Identities = 152/724 (20%), Positives = 318/724 (43%), Gaps = 81/724 (11%)
Query: 414 LSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ 473
L + E E+EM M K + G++K+ L + + L+ K+ +L + +D +
Sbjct: 842 LKSAETEKEMATM----------KEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQL 891
Query: 474 HIEVLKESLTAKEQRA-------AILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 526
++ +++L E+R L+ +V + RLE++E M + T + + + +E
Sbjct: 892 QVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSE 951
Query: 527 QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 586
+I DL+ L E++ + + K++NL E++ ++ ++ L + K+LQ
Sbjct: 952 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDD 1011
Query: 587 LTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEAS 646
L E+ + ++ +L++Q D E ++E KK DL+ L+GDL + S
Sbjct: 1012 LQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQE----KKVRMDLERAKRKLEGDLKLTQES 1067
Query: 647 LLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLK----KAHEAALEARAS 702
++DL+ L KK+ + +E ++ L+++ +LK + E E A
Sbjct: 1068 IMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAE 1127
Query: 703 PEMSDRIQHLEREITRYKDESSKAQAEVDRLLEI------LKEVENEKNDKDKKIAELER 756
+++ L +++R +E S+ E + +E E +K +D + A L+
Sbjct: 1128 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1187
Query: 757 Q-------------VKDQNKKVANLKH-KEQVEKKKS---------AQMLEEARRREDNL 793
+ V + +++ NL+ K+++EK+KS +E+ + + NL
Sbjct: 1188 EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL 1247
Query: 794 NDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQ--VEELLM 851
S+ L+D + ++EE + +L + T ++ E AR EK+ + +L
Sbjct: 1248 EKVSRTLEDQANEYRVKLEEAQRSLNDFT--TQRAKLQTENGELARQLEEKEALISQLTR 1305
Query: 852 AMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE---RRKHLEEVLEMKQEALLAAIS 908
Q++E +K +L ++ L + R + R+ EE E K E L +S
Sbjct: 1306 GKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAE-LQRVLS 1364
Query: 909 EKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSH 968
+ ++ +A + +T+ E A++R ++ +++ K++ R++ + E + K S
Sbjct: 1365 KANSEVA-------QWRTKYETDAIQRTEE--LEEAKKKLAQRLQDAEEAVEAVNAKCSS 1415
Query: 969 SNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDD 1028
+T H+ + I+ L+ +D RS D+ + + L+
Sbjct: 1416 LEKTKHRLQNE--IEDLM-VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESS 1472
Query: 1029 Q---AAWENELQKMTRG--QLQDELEKGERDNAELQEFANAILQQIADHCPDI--LEQVV 1081
Q + EL K+ + + LE +R+N LQE + + +Q+ + ++ LE+V
Sbjct: 1473 QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVR 1532
Query: 1082 NALE 1085
LE
Sbjct: 1533 KQLE 1536
Score = 115 bits (288), Expect = 2e-25
Identities = 138/668 (20%), Positives = 287/668 (42%), Gaps = 83/668 (12%)
Query: 137 STVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKK 196
+ + H+L+ AR + ++LRE + + + ++ S NS W + +
Sbjct: 1329 NALAHALQSARHDC---------DLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYET 1379
Query: 197 ERALRKDE--------ASKITIWKEQYRVVQEENQHMQMTIQALQDELR-----IQRDLN 243
+ R +E A ++ +E V + ++ T LQ+E+ ++R
Sbjct: 1380 DAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA 1439
Query: 244 QLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLN 303
D R + +AE ++ ++ +E E KE L L +++ N
Sbjct: 1440 AAAALDKKQRNFDKILAEW-KQKYEESQSELESSQKEARSLSTELFKLK----------N 1488
Query: 304 ARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREE 363
A +ES++ L K + EE + T +L E +VH LE + +Q E E L+
Sbjct: 1489 AYEESLEHLETF---KRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSA 1545
Query: 364 MHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSN-----GALSTEE 418
+ E + + + K L+ +E K + +ER L + +EE++ K N +L T
Sbjct: 1546 LEEA-EASLEHEEGKILRAQLEFNQIK-AEIERKLAEKDEEMEQAKRNHQRVVDSLQTSL 1603
Query: 419 REEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT-------ELLALQTKLETLTNQFSDS 471
E + EV R K M+ + +++ +LS + ++ +LQ+ L+ Q D+
Sbjct: 1604 DAETRSRNEVLRVKKK-MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1662
Query: 472 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 531
+ + LKE++ E+R +LQ E++ LR +E+ E +++ + +E +
Sbjct: 1663 VRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQN 1722
Query: 532 HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE 591
L + E + LQ ++E ++ R+ E++ + + LE
Sbjct: 1723 TSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1782
Query: 592 EALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK 651
E+TI+ L+ + D E Q + KK L+ L+ +V L+G+L ++ K
Sbjct: 1783 RMKKNMEQTIKDLQHRLDEAE---QIALKGGKKQLQKLEARVRELEGELEAEQ------K 1833
Query: 652 EHASSLASSGLKK-DSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQ 710
+A S+ G++K + R+K L E+ K+ L+++ D +
Sbjct: 1834 RNAESV--KGMRKSERRIKELTYQTEEDKKNLLRLQ--------------------DLVD 1871
Query: 711 HLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKH 770
L+ ++ YK ++ +A+ + + L ++V++E ++ +++ E QV K ++
Sbjct: 1872 KLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGA 1931
Query: 771 KEQVEKKK 778
K+++ ++
Sbjct: 1932 KQKMHDEE 1939
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 139 bits (350), Expect = 1e-32
Identities = 190/891 (21%), Positives = 385/891 (43%), Gaps = 99/891 (11%)
Query: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 213
L+ + E+ R+ D L + E + ++ N +K L +E A + +K+T +
Sbjct: 943 LEDECSELKRDIDDLELTLAKVEKEKHATENKVKN-----LTEEMAGLDEIIAKLT---K 994
Query: 214 QYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAE 273
+ + +QE +Q +QA +D++ +Q G L +E R+ E
Sbjct: 995 EKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGS-----LEQEKKVRMDLE 1049
Query: 274 HERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEED---H 330
++ E L K +E + +E KQ L DE +KK + + L+A+ +E
Sbjct: 1050 RAKRKLEGDL--KLTQESIMDLENDKQQL---DERLKK--KDFELNALNARIEDEQALGS 1102
Query: 331 ERTRRLAEAEMHVHHLESLLEQK-------EKENSMLREEMHRRFENAPDSAKTKALQTV 383
+ ++L E + + LE LE + EK S L E+ E ++ ++Q
Sbjct: 1103 QLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQ-- 1160
Query: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQV 443
IEM + + ++ RDLEE ++ A ++ + + ++ + + +K K+ +
Sbjct: 1161 IEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1220
Query: 444 KQELSRKDTELLA-----------LQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAIL 492
K E + ++ + L+ TL +Q ++ + E + S+ + A L
Sbjct: 1221 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKL 1280
Query: 493 QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKI 552
QTE L +L+EKE ++++ T+ K T ++ DLK L+ + + N L +
Sbjct: 1281 QTENGELSRQLDEKEALISQLTRG-------KLTYTQQLEDLKRQLEEEVKAKNALAHAL 1333
Query: 553 EN-------LQEQLRDKEKQMSSLKERVKSLQADTTNTDT-----ALTTLEEALAEKERT 600
++ L+EQ ++ + + L+ + ++ T A+ EE K++
Sbjct: 1334 QSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1393
Query: 601 IERLKEQRDRDE--REKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLA 658
+RL+E + E K ++ K L++ E + ++ + S A+ LD K+
Sbjct: 1394 AQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL-MVDVERSNAAAAALDKKQRNFDKI 1452
Query: 659 SSGLKKDSRLKTLEIALEQKKEECLKMES-QLKKAHEAALEARASPEMSDRIQHLEREIT 717
+ K+ E+ QK+ L E +LK A+E +LE + + ++ +L+ EI+
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK--NLQEEIS 1510
Query: 718 RYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV--ANLKH---KE 772
++ + + L ++ K++E EK + + E E ++ + K+ A L+ K
Sbjct: 1511 DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1570
Query: 773 QVEKK--KSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITA---E 827
++E+K + + +E+A+R + DS LQ SL D EALR ++ E
Sbjct: 1571 EIERKLAEKDEEMEQAKRNHLRVVDS---LQTSL---DAETRSRNEALRVKKKMEGDLNE 1624
Query: 828 REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLA--EKETHLTNLR 885
E+ L+ A+KQV+ L ++ + +L+ ++++A E+ +L
Sbjct: 1625 MEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAE 1684
Query: 886 AERRKHLEEVLEMKQEALLAAISEKDANIALLE-----LSSSKKKTQEEVAALKREKDRL 940
E + + E E ++ + E + LL L + KKK +++ L+ E +
Sbjct: 1685 LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEA 1744
Query: 941 VQQLKQQTQNRMK------LMADNYEDDHFKSSHSNQTNHKPSPDQIIQPL 985
VQ+ + + K +MA+ + + S+H + K + +Q I+ L
Sbjct: 1745 VQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM--KKNMEQTIKDL 1793
Score = 124 bits (310), Expect = 6e-28
Identities = 184/939 (19%), Positives = 406/939 (43%), Gaps = 147/939 (15%)
Query: 191 SPELKKER------------ALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDEL-- 236
S E +KE AL K EA + + ++ ++QE+N +Q+ +QA QD L
Sbjct: 842 SAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKND-LQLQVQAEQDNLAD 900
Query: 237 ---RIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMEL 293
R + + Q ++ + + + E N + L A+ + E L++ ++++EL
Sbjct: 901 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAE-LTAKKRKLEDECSELKRDIDDLEL 959
Query: 294 RIETQKQTLNARDESIKKLL-EMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQ 352
+ ++ +A + +K L EM + AK T+E + A E H L+ L +
Sbjct: 960 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE------KKALQEAHQQALDDLQAE 1013
Query: 353 KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNG 412
++K N++ + ++ + E D L+ +E + +ER R LE ++++
Sbjct: 1014 EDKVNTLTKAKV--KLEQQVDD-----LEGSLEQEKKVRMDLERAKRKLEGDLKL----- 1061
Query: 413 ALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSK 472
+E + +E N Q+ + L +KD EL AL ++E D +
Sbjct: 1062 ------TQESIMDLE----------NDKQQLDERLKKKDFELNALNARIE-------DEQ 1098
Query: 473 QHIEVLKESLTAKEQRAAILQTEVDA---LRLRLEEKETMLNKKTKQIQDMAEEKGTQAG 529
L++ L + R L+ E++A R ++E+ + L+++ ++I + EE G
Sbjct: 1099 ALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1158
Query: 530 EIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTT 589
+++ +++ QK +L+E E ++L+++ AD+
Sbjct: 1159 V------QIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK----HADSV-------- 1200
Query: 590 LEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD-LKEKVSL------LQGDLSE 642
L E+ ++R+K++ ++++ E + E+D+ +++ +K K +L L+ ++E
Sbjct: 1201 --AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNE 1258
Query: 643 KEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARAS 702
+ + + + L S + ++L+T L ++ +E + SQL + + +
Sbjct: 1259 HRSKAEETQRSVNDLTS----QRAKLQTENGELSRQLDEKEALISQLTRG-----KLTYT 1309
Query: 703 PEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQN 762
++ D + LE E+ + K+ + A ++L+E E+ + AEL+R + N
Sbjct: 1310 QQLEDLKRQLEEEV-KAKNALAHALQSARHDCDLLREQYEEETEAK---AELQRVLSKAN 1365
Query: 763 KKVANLKHKEQVE-----------KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 811
+VA + K + + KKK AQ L+EA + +N L+ + + + I
Sbjct: 1366 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEI 1425
Query: 812 EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ 871
E+L + S A + + +++ EE +E ++E S+ +L +
Sbjct: 1426 EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1485
Query: 872 QSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQ---- 927
+ E HL + E + EE+ ++ ++ + + + +L + K + Q
Sbjct: 1486 NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALE 1545
Query: 928 EEVAALKREKDRLVQ------QLKQQTQNRMKLMADNYED---DHFKSSHSNQTN---HK 975
E A+L+ E+ ++++ Q+K + + ++ + E +H + S QT+
Sbjct: 1546 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET 1605
Query: 976 PSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLI--LRGLTPPASYNLDDDQAAWE 1033
S ++ ++ +++ + +++++ + H + + + L+ L LDD A
Sbjct: 1606 RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRA-- 1663
Query: 1034 NELQKMTRGQLQDELEKGERDN----AELQEFANAILQQ 1068
L++ + ER N AEL+E A+++Q
Sbjct: 1664 -------NDDLKENIAIVERRNNLLQAELEEL-RAVVEQ 1694
Score = 117 bits (294), Expect = 5e-26
Identities = 130/612 (21%), Positives = 280/612 (45%), Gaps = 81/612 (13%)
Query: 414 LSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ 473
L + ERE+EM M K + ++K+ L + + L+ K+ +L + +D +
Sbjct: 840 LKSAEREKEMASM----------KEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQL 889
Query: 474 HIEVLKESLTAKEQRA-------AILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 526
++ +++L E+R L+ +V + RLE++E M + T + + + +E
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSE 949
Query: 527 QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 586
+I DL+ L E++ + + K++NL E++ ++ ++ L + K+LQ +
Sbjct: 950 LKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ------EAH 1003
Query: 587 LTTLEEALAEKER--TIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKE 644
L++ AE+++ T+ + K + ++ + + ++ KK DL+ L+GDL +
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063
Query: 645 ASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAH----------E 694
S++DL+ L KKD L L +E ++ +++ +LK+ E
Sbjct: 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 1123
Query: 695 AALEARASPE--MSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 752
A ARA E SD + LE R ++ +++ + +E E +K +D + A
Sbjct: 1124 AERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIE--MNKKREAEFQKMRRDLEEA 1181
Query: 753 ELERQ-------------VKDQNKKVANLKH-KEQVEKKKS---------AQMLEEARRR 789
L+ + V + +++ NL+ K+++EK+KS +E+ +
Sbjct: 1182 TLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKA 1241
Query: 790 EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE-ESARTNAEKQ--V 846
+ NL + L+D + + + EE + ++ + +T++R + + E +R EK+ +
Sbjct: 1242 KANLEKMCRTLEDQMNEHRSKAEETQRSVND---LTSQRAKLQTENGELSRQLDEKEALI 1298
Query: 847 EELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE---RRKHLEEVLEMKQEAL 903
+L Q+LE +K +L ++ L + R + R+ EE E K E L
Sbjct: 1299 SQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAE-L 1357
Query: 904 LAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDH 963
+S+ ++ +A + +T+ E A++R ++ +++ K++ R++ + E +
Sbjct: 1358 QRVLSKANSEVA-------QWRTKYETDAIQRTEE--LEEAKKKLAQRLQEAEEAVEAVN 1408
Query: 964 FKSSHSNQTNHK 975
K S +T H+
Sbjct: 1409 AKCSSLEKTKHR 1420
Score = 115 bits (287), Expect = 3e-25
Identities = 177/871 (20%), Positives = 367/871 (42%), Gaps = 133/871 (15%)
Query: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 213
LQ +LKE+ + L +++E E + + +++ S EL+ E + R +EA T
Sbjct: 1104 LQKKLKELQARIEELEEELEA-ERTARAKVEKLRSDLSRELE-EISERLEEAGGAT---- 1157
Query: 214 QYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTG-----EPCVAELTEE--N 266
V E N+ + Q +++RDL + Q ++ VAEL E+ N
Sbjct: 1158 --SVQIEMNKKREAEFQ------KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1209
Query: 267 FQRLHAEHERQAKELFL--------------LRKTLEEMELRIETQKQTLNARDESIKKL 312
QR+ + E++ E L + LE+M +E Q ++ E ++
Sbjct: 1210 LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRS 1269
Query: 313 LEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLE----SLLEQKEKENSMLREEMHRR- 367
+ L S+ AK E+ E +R+L E E + L + +Q E L EE+ +
Sbjct: 1270 VNDLTSQ--RAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKN 1327
Query: 368 -FENAPDSAKTKA--LQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMK 424
+A SA+ L+ E + + ++R L E+ ++ +R EE++
Sbjct: 1328 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1387
Query: 425 QMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA 484
+ + K + ++ + ++ + + + +L+ L N+ D +E + A
Sbjct: 1388 EAK------KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA 1441
Query: 485 KEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERK 544
+++ + + + EE ++ L K+ + ++ E + LK+ +
Sbjct: 1442 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE-------LFKLKNAYEESLEH 1494
Query: 545 VNVLQKKIENLQEQLRDKEKQMSS-------LKERVKSLQADTTNTDTALTTLEEALAEK 597
+ +++ +NLQE++ D +Q+ S L++ K L+A+ +AL E +L +
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 598 ERTIER-------LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL--------------- 635
E I R +K + +R EK EE++ K++ + + +
Sbjct: 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Query: 636 ---LQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA 692
++GDL+E E L HA+ +A+ K+ L++L + + ++ ++ LK+
Sbjct: 1615 KKKMEGDLNEMEIQL----SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE- 1669
Query: 693 HEAALEARAS------PEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKND 746
+ A +E R + E+ ++ ER + E + V L + N+K
Sbjct: 1670 NIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKK 1729
Query: 747 KDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRK 806
D +++L+ +V++ ++ N + K + +A M EE ++ + D+S L+ +
Sbjct: 1730 MDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ----DTSAHLERMKKN 1785
Query: 807 KDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAK 866
+ I++L+ L E+ QI A +KQ+++L + +++ ELE+ + +
Sbjct: 1786 MEQTIKDLQHRLDEAEQI-------------ALKGGKKQLQKLEARVRELENELEAEQKR 1832
Query: 867 LSSTQQSLAEKE---THLTNLRAERRKHLEEV--------LEMKQEALLAAISEKDANIA 915
+ + + + + E LT E RK+L + L++K A +E+ AN
Sbjct: 1833 NAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTN 1892
Query: 916 LLELSSSKKKTQEEVAALKREKDRLVQQLKQ 946
L S +K Q E+ + D Q+ +
Sbjct: 1893 L----SKFRKVQHELDEAEERADIAESQVNK 1919
Score = 110 bits (275), Expect = 7e-24
Identities = 156/758 (20%), Positives = 328/758 (43%), Gaps = 90/758 (11%)
Query: 309 IKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRF 368
IK LL+ + + A EE L ++E LE + +E + L+ ++
Sbjct: 836 IKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQ 895
Query: 369 ENAPDSAKT--KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQM 426
+N D+ + + ++ I++ ++K+ M L D EE N L+ ++R+ E +
Sbjct: 896 DNLADAEERCDQLIKNKIQL-EAKVKEMNERLEDEEE------MNAELTAKKRKLEDECS 948
Query: 427 EVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVL---KESLT 483
E +K I ++ L++ + E A + K++ LT + + + I L K++L
Sbjct: 949 E--------LKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 484 AKEQRAAI-LQTEVDAL------RLRLEEK----ETMLNKKTKQIQDMAEEKGTQAGEI- 531
Q+A LQ E D + +++LE++ E L ++ K D+ K G++
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 532 -------------HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQA 578
L + L K+ ++N L +IE+ Q +K++ L+ R++ L+
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEE 1120
Query: 579 DTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEID-NYKKDLKDLKEKVSLLQ 637
+ TA +E+ ++ R +E + E+ + +I+ N K++ + K + L +
Sbjct: 1121 ELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1180
Query: 638 GDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAAL 697
L + + K+HA S+A G + D+ L+ ++ LE++K E + E +
Sbjct: 1181 ATLQHEATAAALRKKHADSVAELGEQIDN-LQRVKQKLEKEKSEFKLELDDVTSNMEQII 1239
Query: 698 EARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK-------NDKDKK 750
+A+A+ E R LE ++ ++ ++ + Q V+ L +++ E ++K+
Sbjct: 1240 KAKANLEKMCRT--LEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEAL 1297
Query: 751 IAELERQVKDQNKKVANLKHK--EQVEKKKS-AQMLEEARRREDNLNDSSQQ-------L 800
I++L R +++ +LK + E+V+ K + A L+ AR D L + ++ L
Sbjct: 1298 ISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAEL 1357
Query: 801 QDSLRKKDD---------------RIEELEEALRESVQITAEREMVLAQEESARTNAEK- 844
Q L K + R EELEEA ++ Q E E + + ++ EK
Sbjct: 1358 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417
Query: 845 ------QVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEM 898
++E+L++ +E+ ++ K + + LAE + ++E +E +
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1477
Query: 899 KQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADN 958
E + +++ L K QEE++ L + + + + + R +L A+
Sbjct: 1478 STELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEK 1537
Query: 959 YEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLK 996
E H+ +I++ LE +Q +++++
Sbjct: 1538 MELQSALEEAEASLEHEEG--KILRAQLEFNQIKAEIE 1573
Score = 62.0 bits (149), Expect = 3e-09
Identities = 94/428 (21%), Positives = 182/428 (42%), Gaps = 67/428 (15%)
Query: 151 IMDLQTQLK---EVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASK 207
I DL QL + + E + +RK +E ++ +L S++ + E E + + +
Sbjct: 1509 ISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE---EGKILRAQLEF 1565
Query: 208 ITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRT----------GEP 257
I E R + E+++ M+ QA ++ LR+ L ++ SR G+
Sbjct: 1566 NQIKAEIERKLAEKDEEME---QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDL 1622
Query: 258 CVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESI---KKLLE 314
E+ + R+ AE ++Q K L + L++ +++++ + + E+I ++
Sbjct: 1623 NEMEIQLSHANRMAAEAQKQVKSL---QSLLKDTQIQLDDAVRANDDLKENIAIVERRNN 1679
Query: 315 MLQSKGLSAKATEEDHERTRRLAEAEM-------HVHHLE--SLLEQKEKENSMLR---- 361
+LQ++ +A E ER+R+LAE E+ + H + SL+ QK+K ++ L
Sbjct: 1680 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQT 1739
Query: 362 --EEMHRRFENAPDSAK---TKALQTVIEMKDSKISS---------MERGLRDLEEEI-- 405
EE + NA + AK T A E+K + +S ME+ ++DL+ +
Sbjct: 1740 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799
Query: 406 -----------QMLKSNGALSTEEREEEMKQMEVYRSHSKFMKN--KIGQVKQELSRKDT 452
Q+ K + E E E +Q S K+ +I ++ +
Sbjct: 1800 AEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRK 1859
Query: 453 ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 512
LL LQ ++ L + K+ E +E + +Q E+D R + E+ +NK
Sbjct: 1860 NLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNK 1919
Query: 513 KTKQIQDM 520
+ +D+
Sbjct: 1920 LRAKSRDI 1927
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 139 bits (350), Expect = 1e-32
Identities = 187/961 (19%), Positives = 398/961 (41%), Gaps = 165/961 (17%)
Query: 195 KKERALRKDEASKITIWKEQYRVVQEENQ----HMQMTIQALQDELRIQRDLNQLFQQDS 250
K++R + EA+K+ I + + ++ +E + H +T L L D + + S
Sbjct: 544 KEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSS 603
Query: 251 SS----RTGEPCVAE-LTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
+ G VAE + ++N ++ ++E++ + L + L ++IE + L
Sbjct: 604 LETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVN 663
Query: 306 DESIKKLLEMLQSKGL--SAKATEEDHERTRRLAEAEMHVHHLESLLEQK-------EKE 356
+++Q + L ++ +++ + E T++ ++ + LE LE+K +
Sbjct: 664 MAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQ----LLTLEKQLEEKIVAYSSIAAK 719
Query: 357 NSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKI---------------SSMERGLRDL 401
N+ L +E+ + E K ++L+T I + KI ME+ + L
Sbjct: 720 NAELEQELMEKNE------KIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERL 773
Query: 402 EEEIQMLKSNGALSTEEREEEMKQMEVY------RSHSKFMKNKIGQVKQELSRKDTELL 455
E +++ K + +E+ M Q ++ S + + G++K+E +KD L
Sbjct: 774 EAQLE--KKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALK 831
Query: 456 ALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTK 515
ALQ ++ T + +E+ KE L ++ L E+ E L KK++
Sbjct: 832 ALQNQVSEETIKVRQLDSALEICKEELVL----------HLNQLEGNKEKFEKQLKKKSE 881
Query: 516 QIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKS 575
++ + +E + H L++ E+ V +LQ ++ Q+ L+ + + L++
Sbjct: 882 EVYCLQKELKIKN---HSLQE---TSEQNV-ILQHTLQQQQQMLQQETIRNGELEDTQTK 934
Query: 576 LQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 635
L+ + + L E+ AEK R +E E + K++++ + +K ++
Sbjct: 935 LEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQ 994
Query: 636 LQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEA 695
+ +LS+ E ++ LK G K L L++ L+Q K E K + +K+ +
Sbjct: 995 YKEELSKMEKEIMHLKR-------DGENKAMHLSQLDMILDQTKTELEKKTNAVKELEK- 1046
Query: 696 ALEARASPEMSDRIQHLE-----------------REITRYKDESSKAQAEVDR------ 732
L+ E+++ +Q E R++ +D KAQ ++
Sbjct: 1047 -LQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIK 1105
Query: 733 -LLEILKEVENEKNDKDKKIAELERQVKDQN----KKVANLKHKEQVEKKKSAQMLEEAR 787
L L+E + E DK +++ E+++ +K++N ++ A + H + ++ +M ++
Sbjct: 1106 DLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKII 1165
Query: 788 RREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVE 847
+ E L S +L++ + +IE L + L+ + + E+E ++ Q E
Sbjct: 1166 KLEGTLEKSELELKEC----NKQIESLNDKLQNAKEQLREKEFIMLQNE----------- 1210
Query: 848 ELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAI 907
QE+ +K ++ TQQ + E E+ + +E +++ QE L
Sbjct: 1211 ----------QEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTRE 1260
Query: 908 SEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSS 967
++++ L E + + Q E+ L E + + Q K+ K +
Sbjct: 1261 QVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKE------------------KDA 1302
Query: 968 HSNQTNHKPSPDQIIQPLLE--LDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNL 1025
H N + ++ + LE + KL + L H +
Sbjct: 1303 HGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHME------------MISH 1350
Query: 1026 DDDQAAWE--NELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQVVNA 1083
++ A W+ + QK + QL ++LEK + + E Q+ + + QQ+ D +++E A
Sbjct: 1351 QENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDR-NEVIEAANEA 1409
Query: 1084 L 1084
L
Sbjct: 1410 L 1410
Score = 127 bits (319), Expect = 6e-29
Identities = 159/714 (22%), Positives = 313/714 (43%), Gaps = 108/714 (15%)
Query: 157 QLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYR 216
Q KE + +L++D+ K+ L S ++ + T E+KKE ++KDEA K Q +
Sbjct: 783 QFKEQEKTMSMLQQDIICKQHHLES-LDRLLTESKGEMKKEN-MKKDEALKAL----QNQ 836
Query: 217 VVQEENQHMQM--TIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEH 274
V +E + Q+ ++ ++EL + LNQL E N ++ +
Sbjct: 837 VSEETIKVRQLDSALEICKEELVLH--LNQL------------------EGNKEKFEKQL 876
Query: 275 ERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTR 334
+++++E++ L+K L+ ++ + ++++ +MLQ + + E+ +
Sbjct: 877 KKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKL- 935
Query: 335 RLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDS----- 389
E V LE L+++ + ++ +M + E+A A K Q VIE+ +
Sbjct: 936 -----EKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKR-QKVIELTGTARQVK 989
Query: 390 -KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELS 448
++ + L +E+EI LK +G E + + Q+++ + Q K EL
Sbjct: 990 IEMDQYKEELSKMEKEIMHLKRDG----ENKAMHLSQLDMI----------LDQTKTELE 1035
Query: 449 RKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET 508
+K + L+ + + +++ Q EVL+ L ++ LR L++ +
Sbjct: 1036 KKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQL 1095
Query: 509 MLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSS 568
L +K I+D+ E ++E K+ + KK E L+ KE+
Sbjct: 1096 SLEEKYTTIKDLTAE----------------LRECKMEIEDKKQELLEMDQALKERNWE- 1138
Query: 569 LKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD 628
LK+R A T+ D T+ E E E+ I +L+ ++ E E +E K ++
Sbjct: 1139 LKQRA----AQVTHLDM---TIREHRGEMEQKIIKLEGTLEKSELELKE----CNKQIES 1187
Query: 629 LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQ 688
L +K+ + L EKE +L ++ S L + R+K +E ++++++ + +Q
Sbjct: 1188 LNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQY---IATQ 1244
Query: 689 LKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKD 748
K+A + E R + E ++Q+ E+ + + +AQ E++RL L++++ +KD
Sbjct: 1245 YKEAIDLGQELRLTRE---QVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKD 1301
Query: 749 KKIAELERQVKDQNKKVANLKHKEQVEKKK---SAQMLEEARRRE--------------- 790
L ++ + A+L+ + Q E KK + L+EA E
Sbjct: 1302 AHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISA 1361
Query: 791 DNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAER-EMVLAQEESARTNAE 843
D+ S QQL + L K +EE ++ + Q +R E++ A E+ T E
Sbjct: 1362 DSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGE 1415
Score = 120 bits (302), Expect = 5e-27
Identities = 164/871 (18%), Positives = 383/871 (43%), Gaps = 122/871 (14%)
Query: 168 LRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQM 227
L +V ++ L + N ++ ++KE++L++ + I + + ++ + +
Sbjct: 296 LEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQ 355
Query: 228 TIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKT 287
+AL + + + Q ++ + E+ E N E++R + L +
Sbjct: 356 RNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSE 415
Query: 288 LEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLE 347
LE ++ ++ K+ N E ++ + ++ E +L E+ + LE
Sbjct: 416 LEILKEKLRQLKEENNNGKEKLRIM-------------AVKNSEVMAQLTESRQSILKLE 462
Query: 348 SLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQM 407
S LE K++ +LR++ EN + A +++ +I S LR LE+ I
Sbjct: 463 SELENKDE---ILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQ 519
Query: 408 LK------------SNGALSTEEREEE---------------------MKQMEVYRSHSK 434
L S +S+ +E+ +K+ E+ + H+
Sbjct: 520 LPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHAN 579
Query: 435 FMKNKIGQ--VKQELSRKDTELLALQTKLETL-----------TNQFSDSKQHIEVLKES 481
N++ Q + S++ ++L +L+T+ L NQ + +KQ+ + +
Sbjct: 580 LTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRL 639
Query: 482 LTAKEQ-RAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV 540
+T E+ R ++Q E + L++ + +T Q Q + EE +A L+ +
Sbjct: 640 VTGIEELRTKLIQIEAENSDLKVN-----MAHRTSQFQLIQEELLEKASNSSKLESEMTK 694
Query: 541 KERKVNVLQKKIE-------NLQEQLRDKEKQMSSLKERVKSLQAD-TTNTDTALTTLEE 592
K ++ L+K++E ++ + + E+++ E+++SL+ + T + E+
Sbjct: 695 KCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEK 754
Query: 593 ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASL--LD- 649
A K+ +E+ KE + ER + +++ + K+ ++ +S+LQ D+ K+ L LD
Sbjct: 755 A---KKIHLEQHKEMEKQIER-LEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDR 810
Query: 650 -LKEHASSLASSGLKKDSRLKTLE--------------IALEQKKEECLKMESQL---KK 691
L E + +KKD LK L+ ALE KEE + +QL K+
Sbjct: 811 LLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKE 870
Query: 692 AHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLE--------ILK----- 738
E L+ + S+ + L++E+ + K+ S + +E + +L+ +L+
Sbjct: 871 KFEKQLKKK-----SEEVYCLQKEL-KIKNHSLQETSEQNVILQHTLQQQQQMLQQETIR 924
Query: 739 --EVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDS 796
E+E+ + +K++++LE++++ Q + A K + + + +A + R++ L +
Sbjct: 925 NGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGT 984
Query: 797 SQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKV 856
++Q++ + + + + ++E+ + + + M L+Q + + ++E+ A++++
Sbjct: 985 ARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKEL 1044
Query: 857 KQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL 916
++ S + +L+ Q ET L N E + L ++ E++ A +S ++ +
Sbjct: 1045 EKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTI 1104
Query: 917 LELSSSKKKTQEEVAALKREKDRLVQQLKQQ 947
+L++ ++ + E+ K+E + Q LK++
Sbjct: 1105 KDLTAELRECKMEIEDKKQELLEMDQALKER 1135
Score = 70.1 bits (170), Expect = 1e-11
Identities = 93/442 (21%), Positives = 185/442 (41%), Gaps = 36/442 (8%)
Query: 551 KIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIER------- 603
++E+ +K+ + SL V SL+ + T+ +L +L E L+ +
Sbjct: 118 EMESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPS 177
Query: 604 LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK 663
E+ D + + NY E V + G ++ + K+ + SS
Sbjct: 178 RSEKLILDVQPSHPGLLNYSP-----YENVCKISGSSTDFQ------KKPRDKMFSSSAP 226
Query: 664 KDSRLKTLEIALEQKKEE--CL-----KMESQLKKAHEAALEARASPEMSDRIQHLEREI 716
D +K+L L + +++ CL + ++ + H ++RA M + Q +
Sbjct: 227 VDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASV 286
Query: 717 TRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLK---HKEQ 773
+++ +AEV ++L+E EN+ K + E E+ +++ ++ LK ++
Sbjct: 287 PILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQT 346
Query: 774 VEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLA 833
+ K++ + EA + L+ + QQ + + +K ++++ EE L ++ E+E
Sbjct: 347 KQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNL-TNCEKENKRL 405
Query: 834 QEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLE 893
QE +E +E L + ++K+E + K KL +E LT R K LE
Sbjct: 406 QERCGLYKSE--LEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILK-LE 462
Query: 894 EVLEMKQEALLAAISEKDANIALLELSSSKKK----TQEEVAALKREKDRLVQQLKQQTQ 949
LE K E L S + N L +++ + Q+E+ + + E L + + Q
Sbjct: 463 SELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPL 522
Query: 950 NRMKLMADNYEDDHFKSSHSNQ 971
R +Y + SS SN+
Sbjct: 523 KRELFGFKSYLSKYQMSSFSNK 544
Score = 67.0 bits (162), Expect = 9e-11
Identities = 98/508 (19%), Positives = 203/508 (39%), Gaps = 67/508 (13%)
Query: 147 RDNTIMDLQTQL-KEVLRENDLLRKDVEVKESKLSSSMNSIKTF-WSPELKKERALR-KD 203
R+ + D QT+L K+V + L+K E KL ++ +LK+++ +
Sbjct: 924 RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTG 983
Query: 204 EASKITIWKEQYRV----VQEENQHMQ------------------MTIQALQDELRIQRD 241
A ++ I +QY+ +++E H++ T L+ + ++
Sbjct: 984 TARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKE 1043
Query: 242 LNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQT 301
L +L + T E+ E Q H E + ++L LR L++ +L +E + T
Sbjct: 1044 LEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTT 1103
Query: 302 LNARDESIKK-----------LLEMLQS--------KGLSAKATEEDHERTRRLAEAEMH 342
+ +++ LLEM Q+ K +A+ T D E E
Sbjct: 1104 IKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQK 1163
Query: 343 VHHLESLLEQKE---KENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLR 399
+ LE LE+ E KE + E ++ + +NA + + K + ++ + +IS +++
Sbjct: 1164 IIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREK--EFIMLQNEQEISQLKK--- 1218
Query: 400 DLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQ----VKQELSRKDTELL 455
++E Q +K E E MK+ E Y + +GQ ++++ TEL
Sbjct: 1219 EIERTQQRMK--------EMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELA 1270
Query: 456 ALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTK 515
+ + + +E +K+ K+ L E+ A ++R E + + K
Sbjct: 1271 EARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIK 1330
Query: 516 QIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKK--IENLQEQLRDKEKQMSSLKERV 573
++ E +A + + + + K++ +K ++ L EQL + ++ ++ V
Sbjct: 1331 KLSAEVESL-KEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTV 1389
Query: 574 KSLQADTTNTDTALTTLEEALAEKERTI 601
+L + + + EAL K +
Sbjct: 1390 SNLHQQVQDRNEVIEAANEALLTKGENV 1417
Score = 65.1 bits (157), Expect = 3e-10
Identities = 136/683 (19%), Positives = 271/683 (39%), Gaps = 86/683 (12%)
Query: 373 DSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLK--SNGALSTEEREEEMKQMEVYR 430
D+ + L V ++ ++ E L+ L EE+ + N + E ++V
Sbjct: 130 DNEEESLLANVASLRH-ELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQP 188
Query: 431 SHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAA 490
SH + + ++S T+ + + + + + Q I+ L+E L Q+ A
Sbjct: 189 SHPGLLNYSPYENVCKISGSSTDFQ--KKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNA 246
Query: 491 ILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQK 550
L T+ +L + E L + ++ M E QA + L++ + E +V+ K
Sbjct: 247 CLVTQNHSLMTKFESIHFELTQSRAKVS-MLESAQQQAASVPILEEQIINLEAEVSAQDK 305
Query: 551 -------KIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIER 603
K+E Q+ + +KE+ + KE L+ D L E+ + +R
Sbjct: 306 VLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVD--------------LLEQTKQGKR 351
Query: 604 LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDL-KEHASSLASSGL 662
+ QR+ +E +++ K + EK+ +Q + E +L + KE+ GL
Sbjct: 352 AERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGL 411
Query: 663 KKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARAS-PEMSDRIQHLEREITRYKD 721
K S L+ L+ L Q KEE + +L+ E A E I LE E+ KD
Sbjct: 412 YK-SELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELEN-KD 469
Query: 722 ESSKAQAEV---DRLLEILKEVENEKNDKDKKIAELER-QVKDQNKKVANLKHKEQVEKK 777
E + + + +R L++ +NE+ D ++ E R +++ K ++ L K ++
Sbjct: 470 EILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGF 529
Query: 778 KS----AQM-----------------------------LEEARRREDNLNDSSQQLQDSL 804
KS QM ++EA ++ + N ++ QL SL
Sbjct: 530 KSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSL 589
Query: 805 RKKDDRIE--ELEEALRESVQITAEREMVLAQEESART---NAEKQVEELLMAMEKVKQE 859
+D E +L E V++ + ++++ T EK+ + L+ +E+++ +
Sbjct: 590 ITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTK 649
Query: 860 LESMKAKLSSTQQSLAEKETHLTNL------RAERRKHLEEVLEMKQEALLAAISEKDAN 913
L ++A+ S + ++A + + + +A LE + K LL + +
Sbjct: 650 LIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEK 709
Query: 914 IALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTN 973
I ++K E+ K EK R ++ ++ L + + H +
Sbjct: 710 IVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLE-------Q 762
Query: 974 HKPSPDQIIQPLLELDQNRSKLK 996
HK QI + +L++ + K
Sbjct: 763 HKEMEKQIERLEAQLEKKDQQFK 785
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 138 bits (348), Expect = 2e-32
Identities = 170/826 (20%), Positives = 378/826 (45%), Gaps = 100/826 (12%)
Query: 146 ARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEA 205
A+D+ L + +++ E L+KD+E+ E + +K L+ +RA +
Sbjct: 1528 AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKES-EVLLQAKRAELEKLK 1586
Query: 206 SKITIWKEQYRVVQEENQHMQMTIQALQDEL-RIQRDLNQLFQQDSSSRTGEPC-----V 259
S++T +++ V+ + H + + LQ + + + DL + + + T E C V
Sbjct: 1587 SQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVT-EKCNHIREV 1645
Query: 260 AELTEE-NFQR--LHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEML 316
L EE +FQ+ L+ + + +L L+++ +E+ E ++ + ++ +K +L+ML
Sbjct: 1646 KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDML 1705
Query: 317 QSKGLSAKATEEDH-------ERTR-RLAEAEMHVHHLESLLEQKEKENSMLREEMHR-R 367
Q + + + H E+T+ + E ++ + +L+ + +Q++ E ++ + R +
Sbjct: 1706 QLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDK 1765
Query: 368 FENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQME 427
E +A+++ALQ+ +E + ++ E+++ K L+ E +M+Q
Sbjct: 1766 REIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKR--VLAAAEENSKMEQ-- 1821
Query: 428 VYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQ 487
S+ + ++ + +++QEL + + + L+L + + Q + ++ + L+E L +
Sbjct: 1822 ---SNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQD 1878
Query: 488 RAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNV 547
+ + + L + ++ +L+++T+ +D++E A D + + K++++ V
Sbjct: 1879 HLNLAKQD---LLHTTKHQDVLLSEQTRLQKDISE----WANRFEDCQKEEETKQQQLQV 1931
Query: 548 LQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEA--LAEKERTIERLK 605
LQ +IE + +L +E L+ K +++ + +T+ TL+E EKE T ++ K
Sbjct: 1932 LQNEIEENKLKLVQQEMMFQRLQ---KERESEESKLETSKVTLKEQQHQLEKELTDQKSK 1988
Query: 606 -----------EQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHA 654
E+R R +E++ ++ +K L K ++S + L EK LL L++ A
Sbjct: 1989 LDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEA 2048
Query: 655 SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLER 714
S ++ D L + E+KK E K + LK+A + + LE+
Sbjct: 2049 DS-----MRADFSLLRNQFLTERKKAE--KQVASLKEA------------LKIQRSQLEK 2089
Query: 715 EITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQV 774
+ K E+S Q E+ + + ++ K++ +++ + + K++AN K E
Sbjct: 2090 NLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLE-- 2147
Query: 775 EKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQ 834
RR+ ++D+ + L+ + KD+ L+ + ++ A+ E +L +
Sbjct: 2148 -------------RRQMEISDAMRTLKSEV--KDEIRTSLKNLNQFLPELPADLEAILER 2192
Query: 835 EESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEE 894
E+ E E L M + + KL+ +Q + ++ LR E+ +H E+
Sbjct: 2193 NENLEGELESLKENLPFTMNE-----GPFEEKLNFSQVHIMDEHWRGEALR-EKLRHRED 2246
Query: 895 VLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRL 940
L +A L K A + L K++T+ + +L+R+ D L
Sbjct: 2247 RL----KAQLRHCMSKQAEV----LIKGKRQTEGTLHSLRRQVDAL 2284
Score = 128 bits (321), Expect = 3e-29
Identities = 197/938 (21%), Positives = 392/938 (41%), Gaps = 159/938 (16%)
Query: 232 LQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEM 291
L++E+ D+ Q + +E+ + LH + +E L +EE+
Sbjct: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
Query: 292 ELRI---ETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLES 348
+ + QK ++ ES+ LE+ +S +E + L + + +
Sbjct: 1381 HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
Query: 349 LLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQML 408
LL + E E S +E+ E D AK LQT + ++ + + E + +L + Q L
Sbjct: 1441 LLAEAESELSCTKEKTKNAVEKFTD-AKRSLLQTESDAEELERRAQETAV-NLVKADQQL 1498
Query: 409 KSNGALSTEEREEEMKQMEVYRSHSKFM-------------KNKIGQVKQELSR------ 449
+S A + + + ++KQ E+ + +K + K K+ + Q+L +
Sbjct: 1499 RSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAE 1558
Query: 450 ----------KDTELL--ALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVD 497
K++E+L A + +LE L +Q + +Q + VL L K++ +LQ +
Sbjct: 1559 RNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMV 1618
Query: 498 ALRLRLEEK----ETMLNKK---TKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNV--- 547
+ L+E ET + +K ++++ + EE Q GE++ + + ERK +
Sbjct: 1619 QAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELN-----VQISERKTQLTLI 1673
Query: 548 ---LQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD---------------TALTT 589
++K+ ENLQ LR K + LK + LQ + T +
Sbjct: 1674 KQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAV 1733
Query: 590 LEEAL---------AEKERTIERLKEQRDRDERE----------KQEEIDNYKKDLKDLK 630
LEE L +++ IE K+ +RD+RE Q ++ K+ +DL+
Sbjct: 1734 LEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQ 1793
Query: 631 EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLK 690
EK + + L++ + L +E++ S+ K + ++ L+ L+Q + L + + +
Sbjct: 1794 EKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDIS 1853
Query: 691 KAHEAALEARAS-----PEMSDRIQHLE------REITRYKD----ESSKAQAEVDRLLE 735
+ E R + E+++ HL T+++D E ++ Q ++
Sbjct: 1854 AMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWAN 1913
Query: 736 ILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLND 795
++ + E+ K +++ L+ ++++ K+ V+++ Q L++ R E++ +
Sbjct: 1914 RFEDCQKEEETKQQQLQVLQNEIEENKLKL--------VQQEMMFQRLQKERESEESKLE 1965
Query: 796 SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEK 855
+S+ +L+++ ++E +E + ++ VLA EE RT E++ E
Sbjct: 1966 TSKV---TLKEQQHQLE--KELTDQKSKLDQVLSKVLAAEERVRTLQEEE-----RWCES 2015
Query: 856 VKQELESMKAKLSSTQQSLAEKETHLTNLRAE-----------------RRKHLEEVLEM 898
+++ L K +LS +Q L EK L L+ E RK E+ +
Sbjct: 2016 LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVAS 2075
Query: 899 KQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRM--KLMA 956
+EAL S+ + N LLE Q+E+A ++ LV Q + R+ +L
Sbjct: 2076 LKEALKIQRSQLEKN--LLEQKQENSCIQKEMATIE-----LVAQDNHERARRLMKELNQ 2128
Query: 957 DNYEDDHFKSSHSNQTNHKPSPDQIIQPLLEL-----DQNRSKLKLYIGHLTTLCHDRDP 1011
YE K +NQ + + +I + L D+ R+ LK L L D +
Sbjct: 2129 MQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEA 2188
Query: 1012 LILRGLTPPASYNLDDD-QAAWENELQKMTRGQLQDEL 1048
++ R + NL+ + ++ EN M G +++L
Sbjct: 2189 ILER------NENLEGELESLKENLPFTMNEGPFEEKL 2220
Score = 120 bits (302), Expect = 5e-27
Identities = 173/796 (21%), Positives = 349/796 (43%), Gaps = 125/796 (15%)
Query: 306 DESIKKLLEMLQSKGLSAKATEEDHER-TRRLAEAEMHV--HHLESLLEQKEKENSMLRE 362
+ + +L +++Q L +K EE R ++R +E EM H+++ LL++K+ + E
Sbjct: 1322 ENEVSRLEDIMQH--LKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEV-E 1378
Query: 363 EMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEE 422
E+HR +Q + KD ++E + +LE E S + E+
Sbjct: 1379 ELHR------------TVQKRQQQKDFIDGNVESLMTELEIE---------KSLKHHEDI 1417
Query: 423 MKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESL 482
+ ++E ++++ + + L+ ++EL + K + +F+D+K+
Sbjct: 1418 VDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKR--------- 1468
Query: 483 TAKEQRAAILQTEVDALRLRLEEKETMLN--KKTKQI-------QDMAEEKGTQAGEIHD 533
++LQTE DA L +ET +N K +Q+ +D+ + K Q + +
Sbjct: 1469 -------SLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKE 1521
Query: 534 LKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEA 593
+ ++ K+ L KK E L E+L+ +K + + ER N D L L+E+
Sbjct: 1522 INKIVAAKDSDFQCLSKKKEKLTEELQKLQKDI-EMAER---------NEDHHLQVLKES 1571
Query: 594 ---LAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDL 650
L K +E+LK Q +Q+E+ + L KE++ LLQG + + +A L +
Sbjct: 1572 EVLLQAKRAELEKLKSQ----VTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEA 1627
Query: 651 KEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQ 710
+ + +K+L L +K E L ++ +K ++ E + +Q
Sbjct: 1628 LRLGETEVTEKCNHIREVKSLLEELSFQKGE-LNVQISERKTQLTLIKQEIEKE-EENLQ 1685
Query: 711 HLEREITRYKDESSKAQAEVDRLLEILK----EVENEKNDKDKKIAELER---QVKDQNK 763
+ R+++++K E+ +L++L+ E++ K D++++ELE+ V ++
Sbjct: 1686 VVLRQMSKHK-------TELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKL 1738
Query: 764 KVANLKHKEQVEKKK---SAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRE 820
++ NL+ Q +K + Q+LE +R + + S+ LQ + E+L+E
Sbjct: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
Query: 821 SVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELE-------SMKAKLSSTQQS 873
+ A+ + VLA E + +E+L + + K++QEL+ S+ +S+ QQ
Sbjct: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
Query: 874 LAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQE---EV 930
L EK + +L+ E ++++ L + ++ LL +D + L E + +K E
Sbjct: 1859 LQEKREAVNSLQ-EELANVQDHLNLAKQDLLHTTKHQD--VLLSEQTRLQKDISEWANRF 1915
Query: 931 AALKREKDRLVQQLK----QQTQNRMKL-----MADNYEDDHFKSSHSNQTNHKPSPDQI 981
++E++ QQL+ + +N++KL M + + +T+ +Q
Sbjct: 1916 EDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQ 1975
Query: 982 IQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTR 1041
Q EL +SKL D ++ + L ++ W L+K T
Sbjct: 1976 HQLEKELTDQKSKL--------------DQVLSKVLAAEERVRTLQEEERWCESLEK-TL 2020
Query: 1042 GQLQDELEKGERDNAE 1057
Q + +L + E+ E
Sbjct: 2021 SQTKRQLSEREQQLVE 2036
Score = 110 bits (276), Expect = 6e-24
Identities = 176/823 (21%), Positives = 350/823 (42%), Gaps = 99/823 (12%)
Query: 162 LRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEE 221
LRE D L + E S+LS + K +R+L + E+ +E R QE
Sbjct: 1435 LREADRLLAEAE---SELSCTKEKTKNAVEKFTDAKRSLLQTESDA----EELERRAQET 1487
Query: 222 NQHMQMTIQALQDELRIQRDLNQ--LFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAK 279
++ Q L+ +DL Q + Q++ + A+ + +FQ L + E+ +
Sbjct: 1488 AVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAK--DSDFQCLSKKKEKLTE 1545
Query: 280 ELFLLRKTLEEMELRIETQKQTLNARDESIK-KLLEMLQSKGLSAKATEEDHERTRRLAE 338
EL L+K +E E + Q L + ++ K E+ + K +E R+L
Sbjct: 1546 ELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGH 1605
Query: 339 AEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGL 398
+ +H L+ + Q + + L+E + ++ T+ + E+K S + +
Sbjct: 1606 KKEELHLLQGSMVQAKAD---LQEALR-----LGETEVTEKCNHIREVK-SLLEELSFQK 1656
Query: 399 RDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQ 458
+L +I K+ L +E E+E + ++V K ++ + L ++ EL L+
Sbjct: 1657 GELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLK 1716
Query: 459 TKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQ 518
+ + ++ K + VL+E L + LQ + +E ++ +L + ++I+
Sbjct: 1717 LQHDQRVSELE--KTQVAVLEEKLELEN-----LQQISQQQKGEIEWQKQLLERDKREIE 1769
Query: 519 DM-AEEKGTQA------GEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE 571
M AE + Q+ E DL++ D+ E+K+ ++ + +E + ++ + L+
Sbjct: 1770 RMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLEL 1829
Query: 572 RVKSLQ--ADTTNTD-----TALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKK 624
V+ LQ D N D ++ +++ L EK + L+E+ Q+ ++ K+
Sbjct: 1830 NVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEEL----ANVQDHLNLAKQ 1885
Query: 625 DLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLK 684
DL + +L LSE+ D+ E A+ +++++ + L++ + +E LK
Sbjct: 1886 DLLHTTKHQDVL---LSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLK 1942
Query: 685 MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK 744
+ Q EM + ERE K E+SK LKE ++
Sbjct: 1943 LVQQ---------------EMMFQRLQKERESEESKLETSKV---------TLKEQQH-- 1976
Query: 745 NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEAR---RREDNLNDSSQQLQ 801
+LE+++ DQ K+ + K +++ + EE R E L+ + +QL
Sbjct: 1977 --------QLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLS 2028
Query: 802 DSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELE 861
+ ++ ++ EL +E+ + A+ ++ Q + R AEKQV L A++ + +LE
Sbjct: 2029 EREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLE 2088
Query: 862 ----SMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMK---QEALLAAISEKDANI 914
K + S Q+ +A E + R+ ++E+ +M+ E ++KD
Sbjct: 2089 KNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLER 2148
Query: 915 ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMAD 957
+E+S + + + EV KD + LK Q +L AD
Sbjct: 2149 RQMEISDAMRTLKSEV------KDEIRTSLKNLNQFLPELPAD 2185
Score = 106 bits (265), Expect = 1e-22
Identities = 143/619 (23%), Positives = 281/619 (45%), Gaps = 78/619 (12%)
Query: 380 LQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE---REEEMKQMEVYRSHSKFM 436
L T +E K+ KIS+ + L +L +EI+ + +TEE EE ++ ++ + +
Sbjct: 435 LDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLL 494
Query: 437 KNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLK---ESLTAKEQRAAILQ 493
++ Q +++ E L L+ ++E + + ++ I+ L+ +SL +K+ +
Sbjct: 495 YKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPK----H 550
Query: 494 TEVDALRLRLEEKETMLNKKTKQIQDMAEEK----GTQAGEIHDLKDMLDVKERKVNVLQ 549
+ + A + E++ ++NK+ +Q++ +E + EI DL++ L + N
Sbjct: 551 SHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEAL 610
Query: 550 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD 609
KK D E +S L+E + +++ T L + EKE ++RL E
Sbjct: 611 KK---------DLEGVISGLQEYLGTIKGQATQAQNECRKLRD---EKETLLQRLTEVE- 657
Query: 610 RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLK 669
+++++++ D ++++++++ L+ L E+ L++ L++ + ++RL
Sbjct: 658 ----QERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLN 713
Query: 670 TLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAE 729
+ Q KEE K+ ++L + ++AL+A LE+E K+ KAQ
Sbjct: 714 LRDAEANQLKEELEKV-TRLTQLEQSALQAE-----------LEKERQALKNALGKAQFS 761
Query: 730 VDRLLEILKEVEN-EKNDKDKKIAELERQVKDQNKKVAN-LKHKEQ--VEKKKSAQMLEE 785
+ KE EN E + K K + + +K Q K N L H V ++ A ++E
Sbjct: 762 EE------KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDE 815
Query: 786 ARRR------EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESAR 839
RR+ E N++ S L SL D ++ E L S ER+ +E +
Sbjct: 816 LRRKLKLGTGEMNIHSPSDVLGKSLA---DLQKQFSEILARSKW---ERDEAQVRERKLQ 869
Query: 840 TNAEKQVEELLMAMEKVKQELE-SMKAKLSSTQQS----LAEKETHLTNLRAERRKHLEE 894
Q E+L E+ +Q E +++A+++ ++ + + E + L+ E K +EE
Sbjct: 870 EEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQ-ENLKSMEE 928
Query: 895 VLEMKQEALLAAISEKDANIA-LLELSSSKK----KTQEEVAALKREKDRLVQQLKQQTQ 949
+ + L A EK+ +A L EL KK K+QE+V L +E +L + + T
Sbjct: 929 IQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAV--ATS 986
Query: 950 NRMKLMADNYEDDHFKSSH 968
+++ D KS H
Sbjct: 987 DKLATAELTIAKDQLKSLH 1005
Score = 99.0 bits (245), Expect = 2e-20
Identities = 165/771 (21%), Positives = 333/771 (43%), Gaps = 106/771 (13%)
Query: 147 RDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRK-DEA 205
++ I QT+L E L ++E E ++ + K +L++ L+K EA
Sbjct: 442 KEKKISAAQTRLSE-------LHDEIEKAEQQILRATEEFK-----QLEEAIQLKKISEA 489
Query: 206 SKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEE 265
K ++K+ +Q N+ Q +AL EL++++ ++ + + + + L +
Sbjct: 490 GKDLLYKQLSGRLQLVNKLRQ---EALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK 546
Query: 266 NFQRLHAEHERQAKE--LFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSA 323
+ + H + ++ KE L ++ K +++E R+ DE + ++ A
Sbjct: 547 DPKHSHMKAQKSGKEQQLDIMNKQYQQLESRL----------DEILSRI----------A 586
Query: 324 KATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTV 383
K TEE + +L E ++ + E+L + E S L+E + T+A
Sbjct: 587 KETEEIKDLEEQLTEGQIAAN--EALKKDLEGVISGLQEYL-----GTIKGQATQAQNEC 639
Query: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQV 443
+++D K + ++R L ++E+E L+ A+ E +E+ ++E + + Q
Sbjct: 640 RKLRDEKETLLQR-LTEVEQERDQLEIV-AMDAENMRKELAELESALQEQHEVNASLQQT 697
Query: 444 KQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRL 503
+ +LS + EL A + NQ LKE L E+ + Q E AL+ L
Sbjct: 698 QGDLSAYEAELEARLNLRDAEANQ----------LKEEL---EKVTRLTQLEQSALQAEL 744
Query: 504 EEKETMLNKKTKQIQDMAEEKGTQAGEIH----DLKDMLDVKERKVNVLQKKIENLQEQL 559
E++ L + Q +EEK + E+H L+D ++ ++++ Q + ++ + L
Sbjct: 745 EKERQALKNALGKAQ-FSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGL 803
Query: 560 RDKEKQMSSLKERVKSLQADT--TNTDTALTTLEEALAEKERTIERL--KEQRDRDEREK 615
E+ + + E + L+ T N + L ++LA+ ++ + + + +RDE +
Sbjct: 804 VRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQV 863
Query: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 675
+E + L+E+++L Q L+ + E A + K+ E +
Sbjct: 864 RE---------RKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQH-----EARI 909
Query: 676 EQKKEECLKMESQLKKAHEAA----LEARASPEMSDRIQHLEREITRYKD-ESSKAQAEV 730
+Q + E ++ LK E L+ + + E +RI RE+ + K E +K+Q +V
Sbjct: 910 QQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQV 969
Query: 731 DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRE 790
L + LK+++ DK KDQ K + K E+ A+ L+EA R
Sbjct: 970 FGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQER---AEELQEAER-- 1024
Query: 791 DNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELL 850
+ + Q L + + IE L+ LR+ E+ + ++ T A QV E+
Sbjct: 1025 --FSRKAAQAARDLTRAEAEIELLQNLLRQK----GEQFRLEMEKTGVGTGANSQVLEI- 1077
Query: 851 MAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQE 901
EK+ + +E + +++ Q L + ++ + LEE+ E+++E
Sbjct: 1078 ---EKLNETMERQRTEIARLQNVL---DLTGSDNKGGFENVLEEIAELRRE 1122
Score = 98.2 bits (243), Expect = 4e-20
Identities = 128/593 (21%), Positives = 256/593 (43%), Gaps = 56/593 (9%)
Query: 502 RLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRD 561
RLE+ L K ++ + M K E+ +L +D ++ L+ ++E L ++
Sbjct: 1327 RLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQK 1386
Query: 562 KEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKE----RTIERLKEQRDRDE--REK 615
+++Q + V+SL + + +L E+ + E E ++R E R+ D E
Sbjct: 1387 RQQQKDFIDGNVESLMTEL-EIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEA 1445
Query: 616 QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 675
+ E+ K+ K+ EK + + L + E+ +L+ A A + +K D +L++L+
Sbjct: 1446 ESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADA 1505
Query: 676 EQKKEECLKMESQLKKAHEAALEARASPE-MSDRIQHLEREITRYKDESSKAQAEVDRLL 734
+ ++ +K E LK+ ++ + + +S + + L E+ + + + A+ D L
Sbjct: 1506 KDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHL 1565
Query: 735 EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 794
++LKE E K ++ +L+ QV Q +++A L Q+ KK EE + ++
Sbjct: 1566 QVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDR--QLGHKK-----EELHLLQGSMV 1618
Query: 795 DSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAME 854
+ LQ++LR + + E +RE + E + Q+ E +
Sbjct: 1619 QAKADLQEALRLGETEVTEKCNHIREVKSLLEELSF-------QKGELNVQISERKTQLT 1671
Query: 855 KVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI 914
+KQE+E + L + +++ +T L N+ ++L+++ L + D +
Sbjct: 1672 LIKQEIEKEEENLQVVLRQMSKHKTELKNIL--------DMLQLENHELQGLKLQHDQRV 1723
Query: 915 ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNH 974
+ LE KTQ V K E + L QQ+ QQ + ++ E D K T
Sbjct: 1724 SELE------KTQVAVLEEKLELENL-QQISQQQKGEIEWQKQLLERD--KREIERMTAE 1774
Query: 975 KPSPDQIIQPLL-ELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWE 1033
+ ++ L E + + K ++ L + + A N +Q+ E
Sbjct: 1775 SRALQSCVECLSKEKEDLQEKCDIWEKKLAQT---------KRVLAAAEENSKMEQSNLE 1825
Query: 1034 NELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQVVNALEE 1086
+L+ R +LQ EL++ RD L +A+ QQ+ + + VN+L+E
Sbjct: 1826 -KLELNVR-KLQQELDQLNRDKLSLHNDISAMQQQLQEK-----REAVNSLQE 1871
Score = 83.2 bits (204), Expect = 1e-15
Identities = 147/725 (20%), Positives = 309/725 (42%), Gaps = 95/725 (13%)
Query: 391 ISSMERGLRDLEE---EIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQEL 447
+ +ER RDLE+ E + LKS EE + + K + + + K ++K +L
Sbjct: 269 LEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDL 328
Query: 448 SRKDTELLALQTKLETLTNQFSDSKQHIEVLK-----ESLTAKEQRAAILQTEVDA---- 498
+ K+ L +L + + +Q + K E L A + D
Sbjct: 329 NTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYI 388
Query: 499 ----LRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH-------DLKDMLDVKERKVNV 547
+ + E+ + + +Q E Q H L L+ KE+K++
Sbjct: 389 GKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISA 448
Query: 548 LQKKIENLQEQLRDKEKQMSSLKERVKSLQAD---TTNTDTALTTLEEALAEKERTIERL 604
Q ++ L +++ E+Q+ E K L+ ++ L + L+ + + + +L
Sbjct: 449 AQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKL 508
Query: 605 KEQR---DRDEREKQEEIDNYKKDLKDLKEKVSLLQG---DLSEKEASLLDLKEHASSLA 658
+++ + ++++EI +K++KDL+ + L S +A ++ +
Sbjct: 509 RQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMN 568
Query: 659 SSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARAS------PEMSDRIQHL 712
+ +SRL + + ++ EE +E QL + AA EA + + + +
Sbjct: 569 KQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTI 628
Query: 713 EREITRYKDESSKAQAEVDRLLEILKEVENEKNDKD----------KKIAELERQVKDQN 762
+ + T+ ++E K + E + LL+ L EVE E++ + K++AELE +++Q+
Sbjct: 629 KGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQH 688
Query: 763 KKVANLKHKEQVEKKKSAQMLE-EARRREDNLNDS-SQQLQDSLRKKDDRIEELEEALRE 820
+ A+L +Q + SA E EAR NL D+ + QL++ L +K R+ +LE++ +
Sbjct: 689 EVNASL---QQTQGDLSAYEAELEARL---NLRDAEANQLKEEL-EKVTRLTQLEQSALQ 741
Query: 821 SVQITAEREMVLAQEESARTNAEKQVE--ELLMAMEKVKQELESMKAKLSSTQQSLAEKE 878
+ ++ ER+ + A+ + EK+ E EL ++ ++ + +K +L Q L
Sbjct: 742 A-ELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHL---- 796
Query: 879 THLTNLRAERRKHLEEVLEMKQEALLAAIS---EKDANIALLELSSSKKKTQEEVAALKR 935
H+ + + V E++++ L +++ L+ +K+ E +A K
Sbjct: 797 NHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKW 856
Query: 936 EKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKL 995
E+D Q +++ Q M L + + Q + + ++ ++ + D+ + +
Sbjct: 857 ERDE-AQVRERKLQEEMALQQEKLA--------TGQEEFRQACERALEARMNFDKRQHEA 907
Query: 996 KLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDN 1055
+ I + H L ++ + E E+Q +T QLQ+ E+ ER
Sbjct: 908 R--IQQMENEIH----------------YLQENLKSME-EIQGLTDLQLQEADEEKERIL 948
Query: 1056 AELQE 1060
A+L+E
Sbjct: 949 AQLRE 953
Score = 53.1 bits (126), Expect = 1e-06
Identities = 82/344 (23%), Positives = 144/344 (41%), Gaps = 59/344 (17%)
Query: 141 HSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL 200
HS ++ DLQ Q E+L + R + +V+E K L++E AL
Sbjct: 830 HSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERK---------------LQEEMAL 874
Query: 201 RKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVA 260
+++ K+ +E++R E +M Q E RIQ+ N++ + ++ E +
Sbjct: 875 QQE---KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEE-IQ 930
Query: 261 ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKG 320
LT+ Q E ER L LR+ ++ +L ++ + D+ +KKL +
Sbjct: 931 GLTDLQLQEADEEKER---ILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKK------ 981
Query: 321 LSAKATEEDHERTRRLAEAEMHV--HHLESLLEQKEKENSMLREEMHRRFENAPDSAKTK 378
A AT + +LA AE+ + L+SL K N EE+
Sbjct: 982 --AVATSD------KLATAELTIAKDQLKSLHGTVMKINQERAEELQE------------ 1021
Query: 379 ALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKN 438
E K + R L E EI++L++ E+ EM++ V + +
Sbjct: 1022 -----AERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGV-GTGANSQVL 1075
Query: 439 KIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESL 482
+I ++ + + R+ TE+ LQ L+ LT SD+K E + E +
Sbjct: 1076 EIEKLNETMERQRTEIARLQNVLD-LTG--SDNKGGFENVLEEI 1116
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 137 bits (345), Expect = 6e-32
Identities = 175/837 (20%), Positives = 357/837 (42%), Gaps = 78/837 (9%)
Query: 151 IMDLQTQLKEVLRENDLLRKDVEVKE--SKLSSSMNSIKTFWSPELKKERALRKDEASKI 208
IM+L+ L ++E LR+ +E + + S++ ++ S + K E R D +I
Sbjct: 466 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLE-VTRTDHQREI 524
Query: 209 TIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQ 268
T KE + +E +Q + ++L + + + + ++ + V L + +
Sbjct: 525 TSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSD--VIALWKSKLE 582
Query: 269 RLHAEHERQAKELF------LLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLS 322
A H++ +EL L +T E EL+ + +K L+ + E +E LQ++ S
Sbjct: 583 TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHE-----IENLQNQQDS 637
Query: 323 AKATEEDHERTRR------LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAK 376
+A R + E E + + S L++ E ++ + E+ + + A K
Sbjct: 638 ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 697
Query: 377 T-KALQT-------VIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV 428
+ LQ VI+ S++ + E L DL+ ++ S G ++ ++++ E
Sbjct: 698 ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA-LRKASSEGKSEMKKLRQQLEAAEK 756
Query: 429 YRSHSKFMKN----KIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA 484
H + KN K + +EL ++ +L LQ L ++ ++ +++LKE
Sbjct: 757 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 816
Query: 485 KEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERK 544
+ A +Q + +L +KE N + ++ + E + + + + +
Sbjct: 817 ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 876
Query: 545 VNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERL 604
L+ I + + D Q++ + + ++ + D LT E + +++IE
Sbjct: 877 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE-- 934
Query: 605 KEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKK 664
+ + E+ +QE ++++ K+L+ K+S L+ + +LK S
Sbjct: 935 -DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS----- 988
Query: 665 DSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESS 724
+++ K EI L+ ++ L E +LK A E E S +Q LE E+ + D++
Sbjct: 989 ETKTKHEEI-LQNLQKTLLDTEDKLKGARE---------ENSGLLQELE-ELRKQADKAK 1037
Query: 725 KAQAEVDRLLEILKEVENEKND-----KDKKIAELERQVKDQNKKVANLKHKEQVEKKKS 779
AQ D ++I++++ EK + +D K + Q + K NLK+ E++ K K
Sbjct: 1038 AAQTAED-AMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKE 1096
Query: 780 A-----QMLEEARRREDNLNDSSQQLQDSLRK-KDDRIEELEEALRESVQITAEREMVLA 833
Q +EE R+ + L ++ Q L +++ ++ EE R ++T+ +++
Sbjct: 1097 LLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKL--- 1153
Query: 834 QEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLE 893
E R+ Q+ E+ K ++ + KA L Q+S++ LT AE K
Sbjct: 1154 --EEERSVLNNQLLEMKKRESKFIKDADEEKASL---QKSISITSALLTEKDAELEKLRN 1208
Query: 894 EVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQN 950
EV ++ E S K + + L S K K + +V L+ + +QL + N
Sbjct: 1209 EVTVLRGE----NASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGN 1261
Score = 109 bits (272), Expect = 2e-23
Identities = 158/782 (20%), Positives = 330/782 (42%), Gaps = 100/782 (12%)
Query: 115 SSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEV 174
S G+ ++T F E M H + ++ + KE+ L K ++
Sbjct: 600 SKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE 659
Query: 175 KESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQD 234
KE+ L A+R SK+ ++Q+ V E+ T+ LQ
Sbjct: 660 KENSL------------------EAIR----SKLDKAEDQHLVEMED------TLNKLQ- 690
Query: 235 ELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELR 294
E I+ ++ Q + +T +NF E + +L LRK E +
Sbjct: 691 EAEIKVKELEVLQAKCNEQT-------KVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 743
Query: 295 IETQKQTLNARDESIKKL-LEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQK 353
++ +Q L A ++ IK L +E ++ T E R +L + ++ + + E
Sbjct: 744 MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 803
Query: 354 EKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGA 413
EKE +L+E+ A S + ++Q ++ +K+ E L +++ L+ N A
Sbjct: 804 EKELQILKEKF------AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLA 857
Query: 414 -LSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSK 472
+ + RE++ ++ ++ ++ K ++N I ++ + ++L + +L +
Sbjct: 858 DMEAKFREKDEREEQLIKAKEK-LENDIAEIMKMSGDNSSQLTKMNDELRL-------KE 909
Query: 473 QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 532
+ +E L+ LT + A+ LQ ++ + ++ E+ + KK + EEK ++
Sbjct: 910 RDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHE------EEKKELERKLS 963
Query: 533 DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 592
DL+ ++ + L+ + E + + K +++ +++LQ +T+ L E
Sbjct: 964 DLEKKMETSHNQCQELKARYERATSETKTKHEEI------LQNLQKTLLDTEDKLKGARE 1017
Query: 593 ALAEKERTIERLKEQRDR--------DEREKQEEIDNYKKD----LKDLKEKVSLLQGDL 640
+ + +E L++Q D+ D + E++ K + L+D K+ + LQ +L
Sbjct: 1018 ENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNEL 1077
Query: 641 SE-KEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEA 699
KE +L +++E L K L T+E QK EE K LK+A AA ++
Sbjct: 1078 DTLKENNLKNVEE---------LNKSKELLTVE---NQKMEEFRKEIETLKQA--AAQKS 1123
Query: 700 RASPEMSDRIQHLEREITRYKDE-SSKAQAEVDR------LLEILKEVENEKNDKDKKIA 752
+ + + L E+ R +DE +S + E +R LLE+ K D D++ A
Sbjct: 1124 QQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKA 1183
Query: 753 ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 812
L++ + + + K E + + +L +L+ Q L+ K + +++
Sbjct: 1184 SLQKSISITSALLTE-KDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVK 1242
Query: 813 ELEEALRESV-QITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ 871
LE L+E+ Q+++ Q + E Q++ L + ++++ + +K K+
Sbjct: 1243 NLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMS 1302
Query: 872 QS 873
++
Sbjct: 1303 EA 1304
Score = 105 bits (261), Expect = 3e-22
Identities = 128/592 (21%), Positives = 264/592 (44%), Gaps = 89/592 (15%)
Query: 134 SMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPE 193
S AS++ L Q R+ + +LQ L EV + + L K++++ + K + + S E
Sbjct: 770 SKASSITREL-QGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA--------SEE 820
Query: 194 LKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLN-QLFQQDSSS 252
+ ++ +K+ +EQ+ ++ + + ++ + ++ + R + + QL +
Sbjct: 821 AVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL 880
Query: 253 RTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKL 312
+ +++ +N +L ++ EL L + +EE++L++ + + +SI+ +
Sbjct: 881 ENDIAEIMKMSGDNSSQLTKMND----ELRLKERDVEELQLKLTKANENASFLQKSIEDM 936
Query: 313 LEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAP 372
+ KA + E ++ E + + S LE+K + + +E+ R+E A
Sbjct: 937 ---------TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERAT 987
Query: 373 DSAKTK-------ALQTVIEMKDSKISSMERG---LRDLEE-EIQMLKSNGALSTEEREE 421
KTK +T+++ +D + E L++LEE Q K+ A + E+ +
Sbjct: 988 SETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQ 1047
Query: 422 EMKQM-----------EVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQ-FS 469
M+QM E + + ++N++ +K+ + K+ E L +L T+ NQ
Sbjct: 1048 IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKEN-NLKNVEELNKSKELLTVENQKME 1106
Query: 470 DSKQHIEVLKESLTAKEQRAAILQTEVDAL-------------RLRLEEKETMLN----- 511
+ ++ IE LK++ K Q+ + LQ E L +LEE+ ++LN
Sbjct: 1107 EFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLE 1166
Query: 512 ---KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSS 568
+++K I+D EEK + I +L K+ ++ +K+ N LR + S
Sbjct: 1167 MKKRESKFIKDADEEKASLQKSISITSALLTEKDAEL----EKLRNEVTVLRGENASAKS 1222
Query: 569 LKERVKSLQADTTNTDTALTTLEEALAEKERTIE----RLKEQRDRDEREKQEEID---- 620
L V++L++D + + LE L E +R + Q D DER ++ +ID
Sbjct: 1223 LHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNS 1282
Query: 621 ---NYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLK 669
+ ++ +DLK KV ++ EA+L + ++ S +K S+ K
Sbjct: 1283 VIVDLQRKNQDLKMKVEMM------SEAALNGNGDDLNNYDSDDQEKQSKKK 1328
Score = 92.4 bits (228), Expect = 2e-18
Identities = 170/788 (21%), Positives = 331/788 (42%), Gaps = 126/788 (15%)
Query: 372 PDSAKTKALQTVI-----EMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQM 426
P AK A++ V+ +K S +S + + + S L TE +++
Sbjct: 288 PAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKI 347
Query: 427 EVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKE 486
+ + +K K ++Q L+ +D E + ++ T+ + +Q + + ++ +
Sbjct: 348 SGTTALQEALKEKQQHIEQLLAERDLE----RAEVAKATSHVGEIEQELALARDG---HD 400
Query: 487 QRAAILQTEVDALRLRLE----EKETMLN------KKTKQIQDMAEEKGTQAGEIHDLKD 536
Q L+ ++D LR +E EK +LN +K + +Q EE+ G++ +
Sbjct: 401 QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDL----E 456
Query: 537 MLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE--AL 594
+ V E+ +I L++ L + ++++ L+ R++S + D +L+ L+E +L
Sbjct: 457 VATVSEKS------RIMELEKDLALRVQEVAELRRRLES-NKPAGDVDMSLSLLQEISSL 509
Query: 595 AEK--------ERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEAS 646
EK +R I LKE E Q+EI K L EK LS++ S
Sbjct: 510 QEKLEVTRTDHQREITSLKEHFGAREETHQKEI----KALYTATEK-------LSKENES 558
Query: 647 LLDLKEHASSLASSGLKK-DSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEM 705
L EHA+ S + S+L+T IA Q+ E LK+ E A A ++
Sbjct: 559 LKSKLEHANKENSDVIALWKSKLETA-IASHQQAMEELKVSFSKGLGTETAEFAELKTQI 617
Query: 706 SDRIQHLEREITRYKDESSKAQA----EVD----RLLEILKEVENEKNDKDKKIAELERQ 757
+ EI +++ +A E++ +L++++KE EN K+ + E Q
Sbjct: 618 EKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQ 677
Query: 758 VKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEA 817
+ + N K +E K K ++L+ + + D+ L+ ++++ +L+
Sbjct: 678 HLVEMEDTLN-KLQEAEIKVKELEVLQAKCNEQTKVIDN---FTSQLKATEEKLLDLDAL 733
Query: 818 LRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEK 877
+ S + +E + + Q E+A EKQ++ L ++++ ES KA SS + L +
Sbjct: 734 RKASSEGKSEMKKLRQQLEAA----EKQIKHL-----EIEKNAESSKA--SSITRELQGR 782
Query: 878 ETHLTNLRAERRK--HLEEVLEMKQEALLAAISEKDANIALLE----------------- 918
E LTNL+ + ++E LE + + L +E ++
Sbjct: 783 ELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 842
Query: 919 --LSSSKKKTQEEVAALK---REKDRLVQQL---KQQTQNR----MKLMADNYEDDHFKS 966
LSS +K +E +A ++ REKD +QL K++ +N MK+ DN
Sbjct: 843 NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDN--SSQLTK 900
Query: 967 SHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLD 1026
+ + +++ L + ++N S L+ I +T A+ +
Sbjct: 901 MNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ--------QEAAKKHE 952
Query: 1027 DDQAAWENELQKM------TRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQV 1080
+++ E +L + + Q Q+ + ER +E + ILQ + D +++
Sbjct: 953 EEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKL 1012
Query: 1081 VNALEESS 1088
A EE+S
Sbjct: 1013 KGAREENS 1020
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 137 bits (345), Expect = 6e-32
Identities = 175/837 (20%), Positives = 357/837 (42%), Gaps = 78/837 (9%)
Query: 151 IMDLQTQLKEVLRENDLLRKDVEVKE--SKLSSSMNSIKTFWSPELKKERALRKDEASKI 208
IM+L+ L ++E LR+ +E + + S++ ++ S + K E R D +I
Sbjct: 501 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLE-VTRTDHQREI 559
Query: 209 TIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQ 268
T KE + +E +Q + ++L + + + + ++ + V L + +
Sbjct: 560 TSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSD--VIALWKSKLE 617
Query: 269 RLHAEHERQAKELF------LLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLS 322
A H++ +EL L +T E EL+ + +K L+ + E +E LQ++ S
Sbjct: 618 TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHE-----IENLQNQQDS 672
Query: 323 AKATEEDHERTRR------LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAK 376
+A R + E E + + S L++ E ++ + E+ + + A K
Sbjct: 673 ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 732
Query: 377 T-KALQT-------VIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV 428
+ LQ VI+ S++ + E L DL+ ++ S G ++ ++++ E
Sbjct: 733 ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA-LRKASSEGKSEMKKLRQQLEAAEK 791
Query: 429 YRSHSKFMKN----KIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA 484
H + KN K + +EL ++ +L LQ L ++ ++ +++LKE
Sbjct: 792 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 851
Query: 485 KEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERK 544
+ A +Q + +L +KE N + ++ + E + + + + +
Sbjct: 852 ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 911
Query: 545 VNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERL 604
L+ I + + D Q++ + + ++ + D LT E + +++IE
Sbjct: 912 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE-- 969
Query: 605 KEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKK 664
+ + E+ +QE ++++ K+L+ K+S L+ + +LK S
Sbjct: 970 -DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS----- 1023
Query: 665 DSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESS 724
+++ K EI L+ ++ L E +LK A E E S +Q LE E+ + D++
Sbjct: 1024 ETKTKHEEI-LQNLQKTLLDTEDKLKGARE---------ENSGLLQELE-ELRKQADKAK 1072
Query: 725 KAQAEVDRLLEILKEVENEKND-----KDKKIAELERQVKDQNKKVANLKHKEQVEKKKS 779
AQ D ++I++++ EK + +D K + Q + K NLK+ E++ K K
Sbjct: 1073 AAQTAED-AMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKE 1131
Query: 780 A-----QMLEEARRREDNLNDSSQQLQDSLRK-KDDRIEELEEALRESVQITAEREMVLA 833
Q +EE R+ + L ++ Q L +++ ++ EE R ++T+ +++
Sbjct: 1132 LLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKL--- 1188
Query: 834 QEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLE 893
E R+ Q+ E+ K ++ + KA L Q+S++ LT AE K
Sbjct: 1189 --EEERSVLNNQLLEMKKRESKFIKDADEEKASL---QKSISITSALLTEKDAELEKLRN 1243
Query: 894 EVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQN 950
EV ++ E S K + + L S K K + +V L+ + +QL + N
Sbjct: 1244 EVTVLRGE----NASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGN 1296
Score = 128 bits (322), Expect = 3e-29
Identities = 202/872 (23%), Positives = 370/872 (42%), Gaps = 158/872 (18%)
Query: 181 SSMNSIKTFWSPELKKERALRKDE---ASKITIWKEQYRVVQEENQHMQMTIQALQDELR 237
SSM+S+ + S + L + A KI+ ++E+ QH++ +L
Sbjct: 317 SSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIE--------QLL 368
Query: 238 IQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIET 297
+RDL + ++S GE E+ H++ EL L M +
Sbjct: 369 AERDLERAEVAKATSHVGE------IEQELALARDGHDQHVLELEAKMDQLRTMVEAADR 422
Query: 298 QKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKEN 357
+K L + E K+ +E LQ + T+ D E +L A + KE E
Sbjct: 423 EKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARI-----------KELEQ 471
Query: 358 SMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTE 417
S+L E KTKA + E++D++++++ R +E L+ + AL +
Sbjct: 472 SLLFE-------------KTKADKLQRELEDTRVATVSEKSRIME-----LEKDLALRVQ 513
Query: 418 EREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEV 477
E E +++E G V LS E+ +LQ KLE +D ++ I
Sbjct: 514 EVAELRRRLE--------SNKPAGDVDMSLSLLQ-EISSLQEKLEVTR---TDHQREITS 561
Query: 478 LKESLTAKEQ----RAAILQTEVDALRLRLEEKETMLNKKTKQIQD-------------- 519
LKE A+E+ L T + L E ++ L K+ D
Sbjct: 562 LKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA 621
Query: 520 -----MAEEK-------GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKE---- 563
M E K GT+ E +LK + E+ Q +IENLQ Q +D E
Sbjct: 622 SHQQAMEELKVSFSKGLGTETAEFAELKTQI---EKMRLDYQHEIENLQNQ-QDSERAAH 677
Query: 564 ---------KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDE-- 612
K M +KE+ SL+A + D A ++ L E E T+ +L+E + +
Sbjct: 678 AKEMEALRAKLMKVIKEKENSLEAIRSKLDKA---EDQHLVEMEDTLNKLQEAEIKVKEL 734
Query: 613 -------REKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKD 665
E+ + IDN+ LK +EK LL D K +S + K L +
Sbjct: 735 EVLQAKCNEQTKVIDNFTSQLKATEEK--LLDLDALRKASS--EGKSEMKKLRQQLEAAE 790
Query: 666 SRLKTLEIA--LEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDES 723
++K LEI E K + E Q ++ L+ S E+S + LE+E+ K++
Sbjct: 791 KQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS-EVSQVKETLEKELQILKEKF 849
Query: 724 SKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQML 783
++A E + ++E N+ + K+++ L ++ + +A+++ K + + ++ Q++
Sbjct: 850 AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLI 909
Query: 784 EEARRREDNL-------NDSSQQL---QDSLRKKDDRIEELEEALRES------VQITAE 827
+ + E+++ D+S QL D LR K+ +EEL+ L ++ +Q + E
Sbjct: 910 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE 969
Query: 828 REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 887
+M + E+S + A+K EE ++++++L ++ K+ ++ E + +E
Sbjct: 970 -DMTVKAEQSQQEAAKKHEEE----KKELERKLSDLEKKMETSHNQCQELKARYERATSE 1024
Query: 888 RRKHLEEVLEMKQEALLAAISE----KDANIALLELSSSKKKTQEEVAALKREKDRLVQQ 943
+ EE+L+ Q+ LL + ++ N LL+ +K ++ A + +D + Q
Sbjct: 1025 TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAM-QI 1083
Query: 944 LKQQTQNRMKLMADNYEDDHFKSSHSNQTNHK 975
++Q T+ + + +A + ED + QTN K
Sbjct: 1084 MEQMTKEKTETLA-SLED-------TKQTNAK 1107
Score = 109 bits (272), Expect = 2e-23
Identities = 158/782 (20%), Positives = 330/782 (42%), Gaps = 100/782 (12%)
Query: 115 SSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEV 174
S G+ ++T F E M H + ++ + KE+ L K ++
Sbjct: 635 SKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE 694
Query: 175 KESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQD 234
KE+ L A+R SK+ ++Q+ V E+ T+ LQ
Sbjct: 695 KENSL------------------EAIR----SKLDKAEDQHLVEMED------TLNKLQ- 725
Query: 235 ELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELR 294
E I+ ++ Q + +T +NF E + +L LRK E +
Sbjct: 726 EAEIKVKELEVLQAKCNEQT-------KVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778
Query: 295 IETQKQTLNARDESIKKL-LEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQK 353
++ +Q L A ++ IK L +E ++ T E R +L + ++ + + E
Sbjct: 779 MKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL 838
Query: 354 EKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGA 413
EKE +L+E+ A S + ++Q ++ +K+ E L +++ L+ N A
Sbjct: 839 EKELQILKEKF------AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLA 892
Query: 414 -LSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSK 472
+ + RE++ ++ ++ ++ K ++N I ++ + ++L + +L +
Sbjct: 893 DMEAKFREKDEREEQLIKAKEK-LENDIAEIMKMSGDNSSQLTKMNDELRL-------KE 944
Query: 473 QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 532
+ +E L+ LT + A+ LQ ++ + ++ E+ + KK + EEK ++
Sbjct: 945 RDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHE------EEKKELERKLS 998
Query: 533 DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 592
DL+ ++ + L+ + E + + K +++ +++LQ +T+ L E
Sbjct: 999 DLEKKMETSHNQCQELKARYERATSETKTKHEEI------LQNLQKTLLDTEDKLKGARE 1052
Query: 593 ALAEKERTIERLKEQRDR--------DEREKQEEIDNYKKD----LKDLKEKVSLLQGDL 640
+ + +E L++Q D+ D + E++ K + L+D K+ + LQ +L
Sbjct: 1053 ENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNEL 1112
Query: 641 SE-KEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEA 699
KE +L +++E L K L T+E QK EE K LK+A AA ++
Sbjct: 1113 DTLKENNLKNVEE---------LNKSKELLTVE---NQKMEEFRKEIETLKQA--AAQKS 1158
Query: 700 RASPEMSDRIQHLEREITRYKDE-SSKAQAEVDR------LLEILKEVENEKNDKDKKIA 752
+ + + L E+ R +DE +S + E +R LLE+ K D D++ A
Sbjct: 1159 QQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKA 1218
Query: 753 ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 812
L++ + + + K E + + +L +L+ Q L+ K + +++
Sbjct: 1219 SLQKSISITSALLTE-KDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVK 1277
Query: 813 ELEEALRESV-QITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ 871
LE L+E+ Q+++ Q + E Q++ L + ++++ + +K K+
Sbjct: 1278 NLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMS 1337
Query: 872 QS 873
++
Sbjct: 1338 EA 1339
Score = 105 bits (261), Expect = 3e-22
Identities = 128/592 (21%), Positives = 264/592 (44%), Gaps = 89/592 (15%)
Query: 134 SMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPE 193
S AS++ L Q R+ + +LQ L EV + + L K++++ + K + + S E
Sbjct: 805 SKASSITREL-QGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA--------SEE 855
Query: 194 LKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLN-QLFQQDSSS 252
+ ++ +K+ +EQ+ ++ + + ++ + ++ + R + + QL +
Sbjct: 856 AVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL 915
Query: 253 RTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKL 312
+ +++ +N +L ++ EL L + +EE++L++ + + +SI+ +
Sbjct: 916 ENDIAEIMKMSGDNSSQLTKMND----ELRLKERDVEELQLKLTKANENASFLQKSIEDM 971
Query: 313 LEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAP 372
+ KA + E ++ E + + S LE+K + + +E+ R+E A
Sbjct: 972 ---------TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERAT 1022
Query: 373 DSAKTK-------ALQTVIEMKDSKISSMERG---LRDLEE-EIQMLKSNGALSTEEREE 421
KTK +T+++ +D + E L++LEE Q K+ A + E+ +
Sbjct: 1023 SETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQ 1082
Query: 422 EMKQM-----------EVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQ-FS 469
M+QM E + + ++N++ +K+ + K+ E L +L T+ NQ
Sbjct: 1083 IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKEN-NLKNVEELNKSKELLTVENQKME 1141
Query: 470 DSKQHIEVLKESLTAKEQRAAILQTEVDAL-------------RLRLEEKETMLN----- 511
+ ++ IE LK++ K Q+ + LQ E L +LEE+ ++LN
Sbjct: 1142 EFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLE 1201
Query: 512 ---KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSS 568
+++K I+D EEK + I +L K+ ++ +K+ N LR + S
Sbjct: 1202 MKKRESKFIKDADEEKASLQKSISITSALLTEKDAEL----EKLRNEVTVLRGENASAKS 1257
Query: 569 LKERVKSLQADTTNTDTALTTLEEALAEKERTIE----RLKEQRDRDEREKQEEID---- 620
L V++L++D + + LE L E +R + Q D DER ++ +ID
Sbjct: 1258 LHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNS 1317
Query: 621 ---NYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLK 669
+ ++ +DLK KV ++ EA+L + ++ S +K S+ K
Sbjct: 1318 VIVDLQRKNQDLKMKVEMM------SEAALNGNGDDLNNYDSDDQEKQSKKK 1363
Score = 95.9 bits (237), Expect = 2e-19
Identities = 167/804 (20%), Positives = 329/804 (40%), Gaps = 123/804 (15%)
Query: 372 PDSAKTKALQTVI-----EMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQM 426
P AK A++ V+ +K S +S + + + S L TE +++
Sbjct: 288 PAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKI 347
Query: 427 EVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKE 486
+ + +K K ++Q L+ +D E + ++ T+ + +Q + + ++ +
Sbjct: 348 SGTTALQEALKEKQQHIEQLLAERDLE----RAEVAKATSHVGEIEQELALARDG---HD 400
Query: 487 QRAAILQTEVDALRLRLE----EKETMLN------KKTKQIQDMAEEKGTQAGEIHDLKD 536
Q L+ ++D LR +E EK +LN +K + +Q EE+ G++
Sbjct: 401 QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTK 460
Query: 537 M--LDVKERKVNVL--QKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 592
+ +KE + ++L + K + LQ +L D S K R+ L+ D L +
Sbjct: 461 LEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKD-------LALRVQ 513
Query: 593 ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE 652
+AE R +E K D D + +++ L+EK+ + + D + + LKE
Sbjct: 514 EVAELRRRLESNKPAGDVDMSL------SLLQEISSLQEKLEVTRTD---HQREITSLKE 564
Query: 653 HASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARA--SPEMSDRIQ 710
H + + K+ +K L A E+ +E ++S+L+ A++ + A ++ I
Sbjct: 565 HFGAREETHQKE---IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA 621
Query: 711 HLEREITRYKDESSKAQA-EVDRLLEILKEVENEKNDKDKKIAELERQVKDQN----KKV 765
++ + K SK E E+ ++E + D +I L+ Q + K++
Sbjct: 622 SHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEM 681
Query: 766 ANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQ-QLQDSLRKKDD---RIEELEEALRE- 820
L+ K K+ LE R + D D +++D+L K + +++ELE +
Sbjct: 682 EALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKC 741
Query: 821 ----------SVQITAEREMVLAQEESARTNAE-----KQVEELLMAMEKVKQELESMK- 864
+ Q+ A E +L + + ++E K++ + L A EK + LE K
Sbjct: 742 NEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKN 801
Query: 865 ---AKLSSTQQSLAEKETHLTNLRAERRK--HLEEVLEMKQEALLAAISEKDANIALLE- 918
+K SS + L +E LTNL+ + ++E LE + + L +E ++
Sbjct: 802 AESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQR 861
Query: 919 ------------------LSSSKKKTQEEVAALK---REKDRLVQQL---KQQTQNR--- 951
LSS +K +E +A ++ REKD +QL K++ +N
Sbjct: 862 SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE 921
Query: 952 -MKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRD 1010
MK+ DN + + +++ L + ++N S L+ I +T
Sbjct: 922 IMKMSGDN--SSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 979
Query: 1011 PLILRGLTPPASYNLDDDQAAWENELQKM------TRGQLQDELEKGERDNAELQEFANA 1064
A+ ++++ E +L + + Q Q+ + ER +E +
Sbjct: 980 --------QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEE 1031
Query: 1065 ILQQIADHCPDILEQVVNALEESS 1088
ILQ + D +++ A EE+S
Sbjct: 1032 ILQNLQKTLLDTEDKLKGAREENS 1055
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 137 bits (344), Expect = 7e-32
Identities = 187/927 (20%), Positives = 405/927 (43%), Gaps = 115/927 (12%)
Query: 141 HSLRQARDNTIMD---LQTQLKEV---LREND-------LLRKDVEVKESKLSSSMNSIK 187
+SLR DN ++D L+T+ +E+ L+E + L RK + +E +L ++++K
Sbjct: 501 NSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLK 560
Query: 188 TFWSPELKKERALRKDEASKITIWKE---QYRVVQE--ENQHMQMTIQALQDELRIQRDL 242
+ L + +SK+ + +E Q + +QE ++Q ++ L L D
Sbjct: 561 NLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDP 620
Query: 243 NQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTL 302
Q+ Q + T VA + L +E+ +++ L T ++ME I+ + L
Sbjct: 621 KQMKQTLFDAET----VALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQL 676
Query: 303 NARDESIKKLLEMLQS--KGLSAKATEEDHERTRRLA---EAEMHVHHLESLLEQKEKEN 357
A+ + L + LQS ++ + D + + L E E + L+ L ++ +EN
Sbjct: 677 EAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEEN 736
Query: 358 SMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTE 417
LREE+ L + ++ S++ + + ++D EE+ ++ T
Sbjct: 737 EALREEV--------------ILLSELKSLPSEVERLRKEIQDKSEELHII-------TS 775
Query: 418 EREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEV 477
E+++ ++ S + + +IG+ K +L+ + + + + D +Q ++
Sbjct: 776 EKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKM 835
Query: 478 LKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDM 537
+ E Q L E L +T L+ KT+++Q+ E + E+ LK+
Sbjct: 836 VLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQ 895
Query: 538 LDVK-------ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQA----------DT 580
L+ + ER+ ++ +K++ E+++ ++ LK+ +SLQ DT
Sbjct: 896 LENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDT 955
Query: 581 TN----TDTALTTLEEALAEKERTIERLKEQRDRD-------EREKQEEIDNYKKDLKDL 629
N T L E+L + + TI LK + + E E D +++ + +
Sbjct: 956 VNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGI 1015
Query: 630 KEKVSLLQGDLSEKEASLLD--LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMES 687
+K L + A + D + E + S +K+ + LE + +K++ +++
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQ----LKT 1071
Query: 688 QLKKAHEAALEARASPE-MSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKND 746
LK+ E +E + + D ++ + + + K+ + K + E+ R + L EVE + +
Sbjct: 1072 DLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKE 1131
Query: 747 KDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRK 806
K +++ E ++Q+ + ++++ ++ K + E ++ L + L+ +
Sbjct: 1132 KSQQLQEKQQQLLNVQEEMSEMQKK-----------INEIENLKNELKNKELTLEHMETE 1180
Query: 807 KDDRIEELEEALRESVQITAEREMVLAQEESARTNAEK---QVEELLMAMEKVKQELESM 863
+ + ++L E E IT ER+++ ++S T + + E+ + K+EL+
Sbjct: 1181 RLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIA 1240
Query: 864 KAKLSSTQQ-------SLAEKETHLTNLRAERRKH--LEE---VLEMKQEAL--LAAISE 909
L Q+ S++EK + N + + H L+E VL +QE L + +SE
Sbjct: 1241 HIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSE 1300
Query: 910 KDANIALLELSSSKKKTQEEVAALKREKDRL-VQQLKQQTQNRMKLMADNYEDDHFKS-S 967
+ LEL + + T++ + E +RL + + Q++Q +K + E D+ K+
Sbjct: 1301 TQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTK--ERDNLKTIK 1358
Query: 968 HSNQTNHKPSPDQIIQPLLELDQNRSK 994
+ + H + I + L ++ +++SK
Sbjct: 1359 EALEVKHDQLKEHIRETLAKIQESQSK 1385
Score = 133 bits (335), Expect = 8e-31
Identities = 177/895 (19%), Positives = 388/895 (43%), Gaps = 133/895 (14%)
Query: 111 PNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQAR--------DNTIMDLQTQLKEVL 162
PN+ +T+ + L ++ ST S AR + + Q ++K +
Sbjct: 1293 PNVKEVSETQETM----NELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLT 1348
Query: 163 RENDLLR---KDVEVKESKLSSSMN-SIKTFWSPELKKERAL----RKDEASKITIWKEQ 214
+E D L+ + +EVK +L + ++ + K+E++L + +E +KI EQ
Sbjct: 1349 KERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ 1408
Query: 215 YRVVQEENQHMQMTIQALQDELRIQRDLNQLF----QQDSSSRTGEPCVAELTE--ENFQ 268
++ +++ +++ I+ L R+Q +++ ++D R E +E + EN +
Sbjct: 1409 FK--PKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIK 1466
Query: 269 RLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEE 328
+ A+H +EL + L+E E I + L+ ++ I + + L++ ++
Sbjct: 1467 EIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEA------INDK 1520
Query: 329 DHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKD 388
+ + + E E + ++ + E +EK N + + + HR+ AK ALQ++ +
Sbjct: 1521 LQNKIQEIYEKEEQFN-IKQISEVQEKVNELKQFKEHRK-------AKDSALQSI----E 1568
Query: 389 SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELS 448
SK+ + L++ +EEIQ++ EE + + +++ R K +I +E
Sbjct: 1569 SKMLELTNRLQESQEEIQIMIKE----KEEMKRVQEALQIERDQLKENTKEIVAKMKESQ 1624
Query: 449 RKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET 508
K+ + L + T N+ + IE LKE ++ ++TE L L E
Sbjct: 1625 EKEYQFLKM-----TAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE 1679
Query: 509 MLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSS 568
+ TK+ D+ + T E LK+ L +E L+K QE+L+ +
Sbjct: 1680 EMRSVTKERDDLRSVEETLKVERDQLKENL--RETITRDLEK-----QEELKIVHMHLKE 1732
Query: 569 LKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD 628
+E + L+ + ++ +++ L E + + LK Q + + QEE+ LK+
Sbjct: 1733 HQETIDKLRGIVSEKTNEISNMQKDL---EHSNDALKAQ----DLKIQEELRIAHMHLKE 1785
Query: 629 LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQ 688
+E + L+G +SEK L S ++KD +E+
Sbjct: 1786 QQETIDKLRGIVSEKTDKL------------SNMQKD-------------------LENS 1814
Query: 689 LKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKD 748
K E E +A+ E ++ K + ++ Q +V + ++ K+++ D+
Sbjct: 1815 NAKLQEKIQELKAN----------EHQLITLKKDVNETQKKVSEMEQLKKQIK----DQS 1860
Query: 749 KKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKD 808
+++LE +N +A H+ E K + + RR E+ L QL++SL++
Sbjct: 1861 LTLSKLE----IENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETK 1916
Query: 809 DRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLS 868
R E+++ L+ + ++ E + + +++ E + + ++++L+ K +L
Sbjct: 1917 ARDLEIQQELKTARMLSKEHKETV-------DKLREKISEKTIQISDIQKDLDKSKDELQ 1969
Query: 869 STQQSLAEKETHLTNLRAE---RRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKK 925
Q L +KE L ++ + K + E+ ++K++ +S + + +L+ +
Sbjct: 1970 KKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHE 2029
Query: 926 TQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQ 980
+ EE+ + +E+D L ++ + +K+ D + + ++ NH+ P++
Sbjct: 2030 SLEEIRIVAKERDEL-----RRIKESLKMERDQFIATLREMIARDRQNHQVKPEK 2079
Score = 122 bits (307), Expect = 1e-27
Identities = 200/949 (21%), Positives = 391/949 (41%), Gaps = 113/949 (11%)
Query: 131 PPVSMASTVPHSLRQARDNTIMDLQTQLKEV-----------------LRENDLLRKDVE 173
P V+ ST L++ R IMDL+ QL+EV L E DLL+K
Sbjct: 333 PYVNEVSTDEALLKRYRKE-IMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQK--- 388
Query: 174 VKESKLSSSMNSIKTFWSPELKKE-RALRKDEAS----KITIWKEQYRVVQEENQHMQMT 228
V+ K+ + + T S L++E +A RK + KI K + N +T
Sbjct: 389 VQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNS-NYADQFNIPTNIT 447
Query: 229 IQALQDELRIQRDLNQLFQQDS----------SSRTGEPCVAELTEENFQR----LHAEH 274
+ + + + R++++ +S S P L +EN + L A++
Sbjct: 448 TKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADY 507
Query: 275 ERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTR 334
+ + LR EEMEL+++ + N DE + LE K + E
Sbjct: 508 DNLVLDYEQLRTEKEEMELKLKEK----NDLDEF--EALERKTKKDQEMQLIHEISNLKN 561
Query: 335 RLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKI--- 391
+ AE++ LE+ L K E +E+ ++ + DS K + ++ + I
Sbjct: 562 LVKHAEVYNQDLENELSSK-VELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDP 620
Query: 392 SSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKD 451
M++ L D E K A E E ++M+ + K M+N I + +L K
Sbjct: 621 KQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKK 680
Query: 452 TELLALQTKLETLTNQFSDSKQHIE--VLKESLTAKEQRAAILQTEVDALRLRLEEKETM 509
+ L+ +L++ N+ + I+ V K+ L E I + + L +EE E +
Sbjct: 681 KMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKE-LNKEVEENEAL 739
Query: 510 LNK--KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMS 567
+ +++ + E EI D + L + + + L ++ + + +++ +++
Sbjct: 740 REEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIG 799
Query: 568 SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDERE---KQEEIDNYKK 624
K+ + + Q++ +TD + + E+ + + E+ +R +E +E +
Sbjct: 800 KTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS 859
Query: 625 DLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLK 684
L LK ++S +L EK + + L +DS L+T+E +K K
Sbjct: 860 SLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE---REKTLITEK 916
Query: 685 MESQLKKAHEAALEARASPEMSDRIQ----HLEREITRYKDESSKAQAEVDRLLEILKEV 740
++ L++ E ++ + +Q L+ +I + + Q ++ LE LK+
Sbjct: 917 LQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQH 976
Query: 741 ENEKNDKDKKIAE-------LER---QVKDQ-NKKVANLKHKEQVEKKKSAQM------- 782
+ N KI+E +E + KD+ +K+ + K+ +E K + +
Sbjct: 977 QETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDN 1036
Query: 783 -LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTN 841
+ E +R+ +L +LQ L E+L+ L+E++++T E QEE
Sbjct: 1037 EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIEN-----QEELRLLG 1091
Query: 842 AEKQVEELLMAMEK---VKQE---------LESMKAKLSSTQQSLAEKETHLTNLR---A 886
E + ++ ++A EK +K+E L ++ KL Q L EK+ L N++ +
Sbjct: 1092 DELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMS 1151
Query: 887 ERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ 946
E +K + E+ +K E ++ + LEL+ + EEV ++ +E+ L + K
Sbjct: 1152 EMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKS 1211
Query: 947 QTQNRMKLMADNYE--------DDHFKSSHSNQTNHKPSPDQIIQPLLE 987
R L E + K +H + H+ + D++ + + E
Sbjct: 1212 FETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260
Score = 81.3 bits (199), Expect = 5e-15
Identities = 146/656 (22%), Positives = 277/656 (42%), Gaps = 93/656 (14%)
Query: 475 IEVLKESLTAKEQRAAILQTEV--DALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 532
+ L+ + TAK + EV D L+ KE M KK Q+++++ E QA E
Sbjct: 317 LTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKK--QLEEVSLETRAQAMEKD 374
Query: 533 DLKDMLDVKERKVNVLQKKIEN------------LQEQLRDKEKQ-----MSSLKERVKS 575
L +L+ K+ V +KIEN LQ++L+ K K+ + + + S
Sbjct: 375 QLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNS 434
Query: 576 LQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 635
AD N T +TT L+ + R+ DE E D + L L E
Sbjct: 435 NYADQFNIPTNITTKTHKLS--------INLLREIDESVCSES-DVFSNTLDTLSE---- 481
Query: 636 LQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEA 695
++ + + K + +++ +SL + L + EQ + E +ME +LK+ ++
Sbjct: 482 IEWNPATKLLNQENIESELNSLRAD-------YDNLVLDYEQLRTEKEEMELKLKEKNDL 534
Query: 696 ALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA--- 752
D + LER+ KD+ + E+ L ++K E D + +++
Sbjct: 535 -----------DEFEALERKTK--KDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKV 581
Query: 753 ELERQVKDQNKKVANLKHKEQVEKKK-----SAQMLEEARRREDNLNDSSQQLQDSLRK- 806
EL R+ +DQ KK+ +++E K S + +E+ ++ + L D+ D+ R+
Sbjct: 582 ELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRES 641
Query: 807 ---KDDRIEELEEALRESV----QITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQE 859
+ + + EL+E ++E Q+ + ++ +Q E+ + +EL A ++ +
Sbjct: 642 AFLRSENL-ELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKL 700
Query: 860 LESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISE-KDANIALLE 918
+ K+ E E +T+L+ E K +EE +++E +L +SE K +
Sbjct: 701 TSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL--LSELKSLPSEVER 758
Query: 919 LSSSKKKTQEEVAALKREKDRLVQQL---KQQTQNRMKLMADNYED-----DHFKSSHSN 970
L + EE+ + EKD+L ++ + + Q ++ + +D ++KS+
Sbjct: 759 LRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQE 818
Query: 971 QTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQA 1030
N K Q + + ++ I +L+ D L L SY
Sbjct: 819 FQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS-SLGALKTELSYK------ 871
Query: 1031 AWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQVVNALEE 1086
ELQ+ TR ++Q+ L + E+ +L E ++ LQ + I E++ LEE
Sbjct: 872 --TQELQEKTR-EVQERLNEMEQLKEQL-ENRDSTLQTVEREKTLITEKLQQTLEE 923
Score = 77.0 bits (188), Expect = 9e-14
Identities = 165/856 (19%), Positives = 357/856 (41%), Gaps = 114/856 (13%)
Query: 142 SLRQARDNTIMDLQTQLKEV-LRENDL--LRKDVEVKESKLSSSMNSIKTFWSPELKKER 198
++++ +N+ LQ +++E+ E+ L L+KDV + K+S K L
Sbjct: 1806 NMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSL---- 1861
Query: 199 ALRKDEASKITIWKEQYRVVQEENQHMQM--TIQALQDELRIQRDLNQLFQQDSSSRTGE 256
L K E + + ++ + ++E M+ ++ +++ L+++RD + Q++ +R E
Sbjct: 1862 TLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLE 1921
Query: 257 PCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEML 316
+ + + L EH+ +L R+ + E ++I ++ L+ + ++K ++ L
Sbjct: 1922 ---IQQELKTARMLSKEHKETVDKL---REKISEKTIQISDIQKDLDKSKDELQKKIQEL 1975
Query: 317 QSKGLSAKATEED----HERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAP 372
Q K L +ED H++ + + + ++ +N L +++H E
Sbjct: 1976 QKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIR 2035
Query: 373 DSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEER------------- 419
AK + + +K+S ++ + L E I + N + E+R
Sbjct: 2036 IVAKER--DELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESL 2093
Query: 420 -------EEEMKQMEVYRSHSKFMKN------KIGQVKQELSRK---DTELLALQTK-LE 462
+E +K+ H + + K + ++ELS + + L LQTK +E
Sbjct: 2094 REKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIE 2153
Query: 463 TL--TNQFSDSKQH--IEVLKESLT-----AKEQRAAILQTEVDALRLRLEEKETMLNKK 513
L NQ + H ++ LK L+ +EQ +I + E+D + ++KE ++
Sbjct: 2154 KLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLI--- 2210
Query: 514 TKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERV 573
+IQ + ++ + E+ DLK ++ +L+ E+ ++ + +Q+ S ++ +
Sbjct: 2211 --KIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEM 2268
Query: 574 KSLQADTTNTDTALTTLEEALAEKE------------RTIERLKEQRDRDEREKQEEIDN 621
+ NT + L+ + ++ R I + E + +ER +
Sbjct: 2269 TQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKE- 2327
Query: 622 YKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI-ALEQKKE 680
+++DLK LKEK L + + SL AS + +D++ + A + E
Sbjct: 2328 WEQDLKSLKEKNEKLFKNYQTLKTSL------ASGAQVNPTTQDNKNPHVTSRATQLTTE 2381
Query: 681 ECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEV 740
+ ++E+ L +A E+A+ + +I +++E+ D +K QA+V + L++
Sbjct: 2382 KIRELENSLHEAKESAMHKES------KIIKMQKELEVTNDIIAKLQAKVHESNKCLEKT 2435
Query: 741 ENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQL 800
+ K+A + K++ + + K +EK K+A+ E +E + ++ +
Sbjct: 2436 KETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFE----KEISATKATVEY 2491
Query: 801 QDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAE-----------KQVEEL 849
Q + I L E LR S Q A+ V+++ + + + + + L
Sbjct: 2492 QKEV------IRLLRENLRRSQQ--AQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKAL 2543
Query: 850 LMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISE 909
++ E ++ E E K K + Q + E N + +K+EA E
Sbjct: 2544 ILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCE 2603
Query: 910 KDANIALLELSSSKKK 925
+ ++SKKK
Sbjct: 2604 NSPKSPKVTGTASKKK 2619
Score = 71.2 bits (173), Expect = 5e-12
Identities = 150/713 (21%), Positives = 280/713 (39%), Gaps = 113/713 (15%)
Query: 148 DNTIMDLQTQLKEVLR-ENDLLR--KDVEVKESKLSSSMNSIKTFWSPELKKERALRKDE 204
D + +LQ +++E+ + E LLR +DV + K++ K F + L + ++R D
Sbjct: 1962 DKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQ-SVRMDN 2020
Query: 205 ---ASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRD-----LNQLFQQDSSSRTGE 256
K+ E+ R+V +E ++ +++ L+++RD L ++ +D + +
Sbjct: 2021 FQLTKKLHESLEEIRIVAKERDELRR----IKESLKMERDQFIATLREMIARDRQNHQVK 2076
Query: 257 PCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIET-QKQTLNARDE-SIKKLLE 314
P L + Q L + + L K EM+ E + +L+ E +K L
Sbjct: 2077 P-EKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELS 2135
Query: 315 MLQSKGLSAKATEEDHERTRRLAE--AEMHVHHLESLLEQKEKENSMLREEMHR---RFE 369
M LS + H A M H + L+ + ++EE H +FE
Sbjct: 2136 MRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFE 2195
Query: 370 N--APDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQME 427
+ K K L I+ R LRDL+ L N L EE ++ + E
Sbjct: 2196 MDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLK-----LNQNMDLHIEEILKDFSESE 2250
Query: 428 VYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHI------------ 475
++F + + ++E+++ E L + +E L N I
Sbjct: 2251 FPSIKTEFQQ--VLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRII 2308
Query: 476 EVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLK 535
++ ES T E+R+A + E + L+EK L K + ++ G Q
Sbjct: 2309 AIMNES-TEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLAS-GAQVNPTTQDN 2366
Query: 536 DMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALA 595
V R + +KI L+ L + ++ + ++ +Q + T+ + L+ +
Sbjct: 2367 KNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVH 2426
Query: 596 EKERTIERLKEQ----RDR---DEREKQEEIDNYKKDLKDL------------------- 629
E + +E+ KE +D+ + +EEI++ K L +
Sbjct: 2427 ESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATK 2486
Query: 630 ------KEKVSLLQGDL--SEKEASLLDLKEHASSLAS---------SGLKKDSR---LK 669
KE + LL+ +L S++ + EH S SG+ ++++ LK
Sbjct: 2487 ATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILK 2546
Query: 670 TLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAE 729
+ I LE K S+LK+ +E ++ + E+ QHL E+ +K+ + K +A
Sbjct: 2547 SEHIRLE-------KEISKLKQQNEQLIKQK--NELLSNNQHLSNEVKTWKERTLKREAH 2597
Query: 730 VDRLLEILKEVENEKNDKDKKI---AELERQVKDQNKKVANLKHKEQVEKKKS 779
K+V E + K K+ A ++Q+ K NL+ E KS
Sbjct: 2598 --------KQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKS 2642
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 136 bits (342), Expect = 1e-31
Identities = 174/749 (23%), Positives = 329/749 (43%), Gaps = 132/749 (17%)
Query: 276 RQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR 335
R K+L R +E+EL + ++ L +D I + + + L +
Sbjct: 218 RLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL----------LNEK 267
Query: 336 LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSME 395
A + + LE L ++ E L E L+ ++K K S M+
Sbjct: 268 QAASPLEPKELEELRDKNESLTMRLHE----------------TLKQCQDLKTEK-SQMD 310
Query: 396 RGLRDLEEEIQMLKSNGALSTEERE--EEMKQM-----EVYRSHSKFMK---NKIGQVKQ 445
R + L EE NG LS + RE ++Q+ E+ HSK + K Q+++
Sbjct: 311 RKINQLSEE------NGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEK 364
Query: 446 ELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES--------------LTAKEQRAAI 491
ELS + L+ K E L + S ++H+ L+++ L +Q AA
Sbjct: 365 ELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAAT 424
Query: 492 LQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKK 551
L L+ R+E ET ++ +Q + E+G E L + + LQ
Sbjct: 425 LAANNTQLQARVEMLET---ERGQQEAKLLAERGHFEEEKQQLSSL-------ITDLQSS 474
Query: 552 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRD 611
I NL + + E+ + R L A + + LTTL + ++++ + LK+Q
Sbjct: 475 ISNLSQAKEELEQASQAHGAR---LTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEK 531
Query: 612 EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE--------HASSLASSGLK 663
+ + + + ++ + L+ +V L L +KE L ++ E HA LA++ +
Sbjct: 532 QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEE 591
Query: 664 KDSRLKTLEIALEQ----KKEECLKME---SQLKKAHEAALEARAS--------PEMSDR 708
+++ L+ + AL+Q +KE+ K+E QL+ A+EA A+ S E+S +
Sbjct: 592 REASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRK 651
Query: 709 IQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQ----NKK 764
++ L+ + + E +AQA+V LE+ E +K + +++A+ + Q+++Q +
Sbjct: 652 VEELQACVETARQEQHEAQAQVAE-LELQLRSEQQKATEKERVAQEKDQLQEQLQALKES 710
Query: 765 VANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQI 824
+ K + EK+++A LEE +R L ++ L + +++ +EE E A R+ ++
Sbjct: 711 LKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE-ERAGRKGLEA 769
Query: 825 ---------TAEREMV---LAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 872
AE E++ LA+ +A+ AE + E+L+ +E+ + + + +QQ
Sbjct: 770 RLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLV-------KEVAAWRERYEDSQQ 822
Query: 873 SLAEK----ETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQE 928
A+ + L L+ E K +E+ E K++ +A I EL S++ Q
Sbjct: 823 EEAQYGAMFQEQLMTLKEECEKARQELQEAKEK--VAGIESHS------ELQISRQ--QN 872
Query: 929 EVAALKREKDRLVQQLKQQTQNRMKLMAD 957
E+A L R +QQ++++ KL D
Sbjct: 873 ELAELHANLARALQQVQEKEVRAQKLADD 901
Score = 121 bits (304), Expect = 3e-27
Identities = 151/693 (21%), Positives = 316/693 (45%), Gaps = 58/693 (8%)
Query: 285 RKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVH 344
RK E + QK + E K + +L +S+K+ D E+ +AE+ V
Sbjct: 72 RKHPSSPECLVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPR-DWEQFEYKIQAELAVI 130
Query: 345 HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE 404
L+ +L+ ++ N L E++ + AP + T E +R +R LE +
Sbjct: 131 -LKFVLDHEDGLN--LNEDLENFLQKAP--VPSTCSSTFPEELSPPSHQAKREIRFLELQ 185
Query: 405 IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETL 464
++ S+ + ++ ++ M+ Q+ E S +D + +LE
Sbjct: 186 -KVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRD------ELELELA 238
Query: 465 TNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEK 524
N ++ LT K+ + A++Q +D L L L EK+ + K+++++ ++
Sbjct: 239 EN------------RKLLTEKDAQIAMMQQRIDRLAL-LNEKQAASPLEPKELEELRDKN 285
Query: 525 GTQAGEIHD-LKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNT 583
+ +H+ LK D+K K + + +KI L E+ D ++ ++ LQ
Sbjct: 286 ESLTMRLHETLKQCQDLKTEK-SQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNEL 344
Query: 584 DTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEK 643
+ + EK+ +E+ +D++ +E+ + + L L+E +S LQ + ++
Sbjct: 345 TEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQE 404
Query: 644 EASLLD-------LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAA 696
+ +L LK+ A++LA++ + +R++ LE Q++ + L ++ H
Sbjct: 405 KGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLA-----ERGHFEE 459
Query: 697 LEARASPEMSDRIQHLEREITRYKDESSKA-QAEVDRLLEILKEVENEKNDKDKKIAELE 755
+ + S ++D +Q +++ K+E +A QA RL + + +E + L
Sbjct: 460 EKQQLSSLITD-LQSSISNLSQAKEELEQASQAHGARLTAQVASLTSE-------LTTLN 511
Query: 756 RQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELE 815
++ Q++++A LK + + ++ + AQ L++ + L +QL SL++K+ +++E+
Sbjct: 512 ATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571
Query: 816 EALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVK-QELESMKAKLSSTQQSL 874
E + Q A++ A+E A + L A+EK K +LE ++ +L ++
Sbjct: 572 EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEAR 631
Query: 875 AEKETHLTNLRAERRKHLEEVLEMKQ--EALLAAISEKDANIALLEL---SSSKKKTQEE 929
+T +T + E+ + +V E++ E E A +A LEL S +K T++E
Sbjct: 632 DSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKE 691
Query: 930 VAALKREKDRLVQQLKQQTQNRMKLMADNYEDD 962
A +EKD+L +QL Q + +K+ + E++
Sbjct: 692 RVA--QEKDQLQEQL-QALKESLKVTKGSLEEE 721
Score = 116 bits (290), Expect = 1e-25
Identities = 160/805 (19%), Positives = 338/805 (41%), Gaps = 73/805 (9%)
Query: 263 TEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLS 322
T+ Q + E E+ EL LR L +E+Q Q R + +++ + Q +G
Sbjct: 963 TQAALQAMEREAEQMGNELERLRAAL------MESQGQQQEERGQQEREVARLTQERG-R 1015
Query: 323 AKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEM-HRRFENAPDSAKTKALQ 381
A+A + R AE EM L++ L ++ E + L+E + H E + L+
Sbjct: 1016 AQADLALEKAAR--AELEMR---LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLR 1070
Query: 382 TVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIG 441
+ + ++ + + ++ L+E++ + A + + E + E + ++ ++
Sbjct: 1071 GLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVS 1130
Query: 442 QVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRA-------AILQT 494
+++Q+ ++ + +L+ LE ++ +E L+ L K Q A Q
Sbjct: 1131 KLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQR 1190
Query: 495 EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIEN 554
E+ A R ++++ ++ Q+ +E + I L++ + + R+V + + +
Sbjct: 1191 ELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKE 1250
Query: 555 LQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDERE 614
L+ + + ++ L+ER++ LQA+T + AL E+ +++ E++
Sbjct: 1251 LKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASEN 1310
Query: 615 KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK-EHAS--SLASSGLKKD---SRL 668
++E+ + + ++L +++ Q +KE +L L+ EH S +L S L +L
Sbjct: 1311 LRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQL 1370
Query: 669 KTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRI-------------QHLERE 715
+ + A E++ E L+ Q A L RA E+ + I Q L E
Sbjct: 1371 QAEQAAAEKRHREELEQSKQAAGGLRAEL-LRAQRELGELIPLRQKVAEQERTAQQLRAE 1429
Query: 716 ITRYKD-------------ESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQN 762
Y + E ++ E L EVE ++ ++K + EL D
Sbjct: 1430 KASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQ-AREKYVQELAAVRADAE 1488
Query: 763 KKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESV 822
++A ++ + Q ++ M + + + + Q+ Q+ +K ++E+LE RE
Sbjct: 1489 TRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQT 1548
Query: 823 QITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLT 882
+ E LA + A +++++ + + +QE + ++A+L+ Q L++KE
Sbjct: 1549 KQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQ--- 1605
Query: 883 NLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQ 942
AE K E + +A +K N L E S ++ Q+E L+ E +RL
Sbjct: 1606 --AAEHYKLQMEKAKTHYDA------KKQQNQELQEQLRSLEQLQKENKELRAEAERLGH 1657
Query: 943 QLKQ------QTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSK-- 994
+L+Q + + + + + +H++Q Q+ L+ + ++K
Sbjct: 1658 ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQ 1717
Query: 995 LKLYIGHLTTLCHDRDPLILRGLTP 1019
L L I L C + PL + P
Sbjct: 1718 LDLSIDSLDLSCEEGTPLSITSKLP 1742
Score = 110 bits (274), Expect = 9e-24
Identities = 189/891 (21%), Positives = 372/891 (41%), Gaps = 123/891 (13%)
Query: 140 PHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERA 199
P L + RD L +L E L++ +D++ ++S++ +N + S E
Sbjct: 275 PKELEELRDKN-ESLTMRLHETLKQC----QDLKTEKSQMDRKINQL----SEENGDLSF 325
Query: 200 LRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSS-SRTGEPC 258
++ AS + ++ + EE H + T + L+ + +++++L+ Q E
Sbjct: 326 KLREFASHLQQLQDALNELTEE--HSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEIL 383
Query: 259 VAELT--EENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ---TLNARDESIKKLL 313
+L+ EE+ +L ++ E+ L ++ L++ET KQ TL A + ++ +
Sbjct: 384 QGKLSQLEEHLSQLQDNPPQEKGEV------LGDV-LQLETLKQEAATLAANNTQLQARV 436
Query: 314 EMLQSKGLSAKATEEDHERTRRLAEA---EMHVHHLESLLEQKEKENSMLREEMHRRFEN 370
EML+ TE + + LAE E L SL+ + S L + E
Sbjct: 437 EMLE--------TERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNL-SQAKEELEQ 487
Query: 371 APDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYR 430
A + + V + S+++++ ++ ++E+ LK + + ++Q E
Sbjct: 488 ASQAHGARLTAQVASLT-SELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQE--- 543
Query: 431 SHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAA 490
S+ +++++ Q+ L +K+ +L + K E + + H + L TA E+R A
Sbjct: 544 QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE------ATRQDHAQQLA---TAAEEREA 594
Query: 491 ILQTEVDALRLRLE----EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVN 546
L+ E DA +LE EK L +Q+Q E + + + + RKV
Sbjct: 595 SLR-ERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVE 653
Query: 547 VLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA----------LTTLEEALAE 596
LQ +E +++ + + Q++ L+ +++S Q T + L L+E+L
Sbjct: 654 ELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKV 713
Query: 597 KERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASS 656
+ ++E K + E+Q I K + + L E+ + +L E+ A L+
Sbjct: 714 TKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQ 773
Query: 657 LASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQH---LE 713
L + + ++ + E+A + + E + AA R + Q+ +
Sbjct: 774 LGEAH-QAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQ 832
Query: 714 REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQ 773
++ K+E KA+ E+ E + +E+ E Q+ Q ++A L
Sbjct: 833 EQLMTLKEECEKARQELQEAKEKVAGIESHS----------ELQISRQQNELAEL----H 878
Query: 774 VEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRES--VQITAEREMV 831
++ Q ++E R L D LQ+ + + LE +R++ Q TA RE+V
Sbjct: 879 ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELV 938
Query: 832 LAQEESARTNAEKQVEEL--------------LMAMEK----VKQELESMKAKLSST--- 870
+E AR ++Q E L L AME+ + ELE ++A L +
Sbjct: 939 ---KEPARA-GDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQ 994
Query: 871 -QQSLAEKETHLTNLRAER-RKHLEEVLEMKQEA-----LLAAISEKDANIALLELS--- 920
Q+ ++E + L ER R + LE A L A++E+ A L+ +
Sbjct: 995 QQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAH 1054
Query: 921 --SSKKKTQEEVAALKREKDRLVQQLKQ--QTQNRMKLMADNYEDDHFKSS 967
+ K+ +E+A L+ + +++L++ QT ++K E +H S
Sbjct: 1055 ALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGS 1105
Score = 77.0 bits (188), Expect = 9e-14
Identities = 115/609 (18%), Positives = 239/609 (39%), Gaps = 49/609 (8%)
Query: 166 DLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHM 225
+ LR +V E + + L+ ERA R + S + + Q +E H
Sbjct: 1123 EALRAEVSKLEQQCQKQQEQADSL-ERSLEAERASRAERDSALETLQGQLEEKAQELGHS 1181
Query: 226 QMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLR 285
Q + + Q EL R Q S + + +R ++ +E+ +L
Sbjct: 1182 QSALASAQRELAAFR---TKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILN 1238
Query: 286 KTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHH 345
+ + E E + K+ + A E +KL E L+ L A+ R + V
Sbjct: 1239 RQVLEKEGESKELKRLVMAESEKSQKLEERLRL--LQAETASNSARAAERSSALREEVQS 1296
Query: 346 LESLLEQKEKENSMLREEMHRRFENAPD-SAKTKALQTVIEMKDSKISSMERGLRDLEEE 404
L E++ + LR+E+ + E A + + KA Q K+ +S+++ +
Sbjct: 1297 LREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQAL 1356
Query: 405 IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETL 464
+ L L + + E+ + +R + K G ++ EL R EL
Sbjct: 1357 VSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQREL---------- 1406
Query: 465 TNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEK 524
+ L++ + +E+ A L+ E + E+ +ML K+ + E+
Sbjct: 1407 --------GELIPLRQKVAEQERTAQQLRAE----KASYAEQLSML----KKAHGLLAEE 1450
Query: 525 GTQAGEIHDL-KDMLDV-----KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQA 578
GE +L + L+V +E+ V L + + +L + +++ S ++ + A
Sbjct: 1451 NRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTA 1510
Query: 579 DTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQG 638
+ + E+ + + EQ + +RE+ ++++ K L D + + Q
Sbjct: 1511 KYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQ 1570
Query: 639 DLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALE 698
L +A + ++ A L ++L L+ L QK++ + Q++K A
Sbjct: 1571 KLKAVQAQGGESQQEAQRL-------QAQLNELQAQLSQKEQAAEHYKLQMEK---AKTH 1620
Query: 699 ARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQV 758
A + + +Q R + + + E+ + +AE +RL L++ + + ++ L QV
Sbjct: 1621 YDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQV 1680
Query: 759 KDQNKKVAN 767
+ +VA+
Sbjct: 1681 RSLEAQVAH 1689
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 135 bits (341), Expect = 2e-31
Identities = 210/903 (23%), Positives = 378/903 (41%), Gaps = 150/903 (16%)
Query: 156 TQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFW--SPELKKERA-LRKDEASKITIWK 212
+++ ++ +EN L K VE+ E+++ S++ S +L KE+A L K + +
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550
Query: 213 EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
Q +++++EN+H+ T+ +L+ +I + E V ++ +EN + LH
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQI---------------SAEARVKDIEKEN-KILHE 594
Query: 273 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
+ + +L +IE +K+ IKK LE + KG
Sbjct: 595 SIKETSSKLS-----------KIEFEKR-------QIKKELEHYKEKG------------ 624
Query: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
R E E +HHLE KEN +L++++ K IE + + S
Sbjct: 625 -ERAEELENELHHLE-------KENELLQKKI----------TNLKITCEKIEALEQENS 666
Query: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT 452
+ER R L++ + K N E E+E Q++ + + +N + L
Sbjct: 667 ELERENRKLKKTLDSFK-NLTFQLESLEKENSQLD--EENLELRRNV-----ESLKCASM 718
Query: 453 ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 512
++ LQ + + L ++ K+ +E+LK S K +R + +D RL++ NK
Sbjct: 719 KMAQLQLENKELESEKEQLKKGLELLKASFK-KTERLEVSYQGLDIENQRLQKTLENSNK 777
Query: 513 KTKQ----IQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSS 568
K +Q +QD+ E T + +LK + +++ L+K+ ++L+++ EK
Sbjct: 778 KIQQLESELQDLEMENQTLQKNLEELK----ISSKRLEQLEKENKSLEQETSQLEKDKKQ 833
Query: 569 LKERVKSLQADTTNTDTALT-------TLEEALAEKERTIERLKEQRDRDEREKQEEIDN 621
L++ K L+ DT L LE+ + I KE R + ++E +
Sbjct: 834 LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKEL 893
Query: 622 YKKDLKDLKEKVSLLQGDLSEK---EASLLDLKEHASSLASSGLKK-----------DSR 667
K+ D+K V+L + +SEK + DL++ L GL K DSR
Sbjct: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSR 953
Query: 668 LKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKD--ESSK 725
K LE K E LK ++K+ AALEAR E ++ Q L +E+ K E+ K
Sbjct: 954 YK----LLESKLESTLKKSLEIKEEKIAALEARLE-ESTNYNQQLRQELKTVKKNYEALK 1008
Query: 726 AQAEVDRLLEILKEVENEKNDKDKKIAELERQ---VKDQNKKVANLKHKEQVEKKKSAQM 782
+ + +R+++ + E N +++ E R+ VKD+ +V Q EK+
Sbjct: 1009 QRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1068
Query: 783 LEEARRREDNLNDSSQQLQD---SLRKKDDRIEELEEALR--------ESVQITAEREMV 831
L++ + +NL LQ SL++++ ++ L+ +S + + +
Sbjct: 1069 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1128
Query: 832 LAQEESARTNAEKQVEE------LLMAMEKVKQELESMKAKLSSTQQSLAEKETHL---- 881
L Q+ S E ++E L ++ K ++LE + + +S +SL K L
Sbjct: 1129 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAH 1188
Query: 882 TNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSK----KKTQEEVAA----L 933
NL E R LE + LL + + +L++ K K E VAA L
Sbjct: 1189 KNLEVEHRD-----LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKL 1243
Query: 934 KREKDRLVQQLKQQTQNRMKLMADNYE-DDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR 992
E DRL Q + L D+ +S QT + ++ + +LD
Sbjct: 1244 CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITS 1303
Query: 993 SKL 995
+KL
Sbjct: 1304 TKL 1306
Score = 130 bits (328), Expect = 5e-30
Identities = 200/903 (22%), Positives = 391/903 (43%), Gaps = 81/903 (8%)
Query: 216 RVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTE--ENFQRLHAE 273
R++ E ++H + I EL +RD F +SS PC + + E+ Q L E
Sbjct: 199 RLIDERDEHSETII-----ELSEERD-GLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE 252
Query: 274 HERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERT 333
++ LR+ LEE ++ KQ L + +K+L + + A++ +
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL 312
Query: 334 RRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISS 393
L E + V LES + + ++ + R E D+ +T++E + +
Sbjct: 313 DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 394 MERGLRDLEEE----------IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQV 443
L +LE+E ++M + EE EE +E+ + S +G
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE 432
Query: 444 KQELSRKDTELLALQTKLETLTNQFSDSK-QHIEVLKESL--TAKEQRAAILQTEVDALR 500
+++SR A Q L N+ + S+ +E+ +SL T +E R + E +A +
Sbjct: 433 LEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASK 492
Query: 501 -LRLEEKETMLNKKTKQIQ-DMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQ 558
L++E++ L+KK + ++ ++ +EK + + KD++ K + ++ EN + Q
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 559 LRDKEKQMSSLKERVKSL-QADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQE 617
++ E++ L + V SL Q + + + +E+ +I+ + + E EK++
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612
Query: 618 EIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLK-TLE--IA 674
KK+L+ KEK G+ +E+ + L E + L KK + LK T E A
Sbjct: 613 ----IKKELEHYKEK-----GERAEELENELHHLEKENELLQ---KKITNLKITCEKIEA 660
Query: 675 LEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLL 734
LEQ+ E + +LKK + + ++ +++ LE+E ++ +E+ + + V+ L
Sbjct: 661 LEQENSELERENRKLKKTLD------SFKNLTFQLESLEKENSQLDEENLELRRNVESLK 714
Query: 735 EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRE--DN 792
++ + + + +E E+ K A+ K E++E +E R ++ +N
Sbjct: 715 CASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLEN 774
Query: 793 LNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMA 852
N QQL+ L+ + + L++ L E ++I+++R L Q E + E++ +L
Sbjct: 775 SNKKIQQLESELQDLEMENQTLQKNL-EELKISSKR---LEQLEKENKSLEQETSQLEKD 830
Query: 853 MEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV------------LEMKQ 900
+++++E + ++ + +L E + NL E + +E+ LE +
Sbjct: 831 KKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
Query: 901 EALL--AAISEKDANIALLELSSSKKKTQE----------EVAALKREKDRLVQQLKQQT 948
+ L+ A I K +L S K KTQ+ E+ + K+RL+ +
Sbjct: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
Query: 949 QNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHD 1008
+R KL+ E KS + ++ + Q R +LK + L
Sbjct: 951 DSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1010
Query: 1009 RDPLILRGLTPPASYNLDDDQAAWENELQKMTRG--QLQDELEKGERDNAELQEFANAIL 1066
+D + +PP S + WE E Q+ TR +++D L + ER+NA LQ A+
Sbjct: 1011 QDEERMVQSSPPIS----GEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK 1066
Query: 1067 QQI 1069
Q+
Sbjct: 1067 TQL 1069
Score = 119 bits (298), Expect = 2e-26
Identities = 177/852 (20%), Positives = 365/852 (42%), Gaps = 114/852 (13%)
Query: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSI--KTFWSPELKKERALRKDEASKITIW 211
++ +LK + +EN L D ++++ K +L+ E + K+ I +
Sbjct: 284 MEIELKRLQQENMNLLSDAR-SARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFY 342
Query: 212 KEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLH 271
K + ++E+NQ + T L+D+L +R + EL +EN Q
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQL-------------EGTRARSDKLHELEKENLQLKA 389
Query: 272 AEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHE 331
H+ + + +K E ME + + + DES+ E+ E
Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWEL------------EQIS 437
Query: 332 RTRRLAEAEMHV--HHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKD- 388
RT L+EA H + L + +L+ EM EN + + L+T ++ +
Sbjct: 438 RTSELSEAPQKSLGHEVNELTSSR-----LLKLEM----ENQSLTKTVEELRTTVDSVEG 488
Query: 389 --SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQE 446
SKI ME+ + L +++++L++ E +E + ++ ++ SK + + Q+++
Sbjct: 489 NASKILKMEKENQRLSKKVEILEN-------EIVQEKQSLQNCQNLSKDLMKEKAQLEKT 541
Query: 447 L----SRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLR 502
+ + ++ L+ + E L S +Q ++ + E R ++ E L
Sbjct: 542 IETLRENSERQIKILEQENEHLNQTVSSLRQRSQI------SAEARVKDIEKENKILHES 595
Query: 503 LEEKETMLNK---KTKQIQDMAE---EKGTQA----GEIHDLKDMLDVKERKVNVLQ--- 549
++E + L+K + +QI+ E EKG +A E+H L+ ++ ++K+ L+
Sbjct: 596 IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITC 655
Query: 550 KKIENLQEQLRDKEKQMSSLKERV---KSLQADTTNTDTALTTLEEALAEKERTIERLK- 605
+KIE L+++ + E++ LK+ + K+L + + + L+E E R +E LK
Sbjct: 656 EKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKC 715
Query: 606 -----EQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 660
Q + +E + E + KK L+ LK S K+ L++ + +
Sbjct: 716 ASMKMAQLQLENKELESEKEQLKKGLELLK---------ASFKKTERLEVSYQGLDIENQ 766
Query: 661 GLKKDSRLKTLEIALEQKKEECLKMESQL--KKAHEAALEARASPEMSDRIQHLEREITR 718
L+K +I + + + L+ME+Q K E + ++ ++ + LE+E ++
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQ 826
Query: 719 YKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKH---KEQVE 775
+ + + + E RL + + + + + KI LE++ K +K++ K + +
Sbjct: 827 LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKEL 886
Query: 776 KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE 835
+K++ ++++ A L + L K +LE+ E +I +E +L E
Sbjct: 887 EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE 946
Query: 836 ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAER---RKHL 892
+S + K +E L + +K+ LE + K+++ + L E + LR E +K+
Sbjct: 947 QSTDDSRYKLLESKLES--TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY 1004
Query: 893 EEVLEMKQEALLAAIS-------------EKDANIALLELSSSKKKTQEEVAALKREKDR 939
E + + + E + S ++ LL++ + + A L+ EK
Sbjct: 1005 EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQA 1064
Query: 940 LVQQLKQ-QTQN 950
L QLKQ +TQN
Sbjct: 1065 LKTQLKQLETQN 1076
Score = 110 bits (275), Expect = 7e-24
Identities = 173/777 (22%), Positives = 335/777 (43%), Gaps = 135/777 (17%)
Query: 153 DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 212
+L+ +L + +EN+LL+K + + L + I+ + ER RK + + +
Sbjct: 629 ELENELHHLEKENELLQKKI----TNLKITCEKIEALEQENSELERENRKLKKTLDSFKN 684
Query: 213 EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
+++ E ++ Q+ ++ L ++R++ L + +A+L EN + L +
Sbjct: 685 LTFQLESLEKENSQLD----EENLELRRNVESL-------KCASMKMAQLQLEN-KELES 732
Query: 273 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
E E+ K L LL+ + ++ E R+E Q L+ ++ ++K LE K ++ +D E
Sbjct: 733 EKEQLKKGLELLKASFKKTE-RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 333 TRRLAEAEMHVHHLESL-LEQKEKENSMLREEMHRRFENAPDSAK-TKALQTVIEMKDS- 389
+ + + + S LEQ EKEN L +E + ++ K K L+ E+KD+
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 390 ------KISSMERGLRDLEEEIQMLKSNGALSTEEREE----------EMKQMEVYRSHS 433
KI ++E+ + L +EI + K + E +E ++K + R
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL 911
Query: 434 KFMKNKIGQVKQELSRKDTELLALQTKLETLTNQ---FSDSKQHI------EVLKESLTA 484
K K Q+ +L + EL + E L + DS+ + LK+SL
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEI 971
Query: 485 KEQRAAILQTEVDAL-----RLRLEEKETMLNKKT-KQIQD---MAEEKGTQAGEIHD-- 533
KE++ A L+ ++ +LR E K N + KQ QD M + +GE +
Sbjct: 972 KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE 1031
Query: 534 ------LKDMLDVKERKVNV------LQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT 581
+++L VK+R + V LQ + + L+ QL+ E Q ++L+ ++ +LQ T
Sbjct: 1032 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1091
Query: 582 NTDTALTTLEEALAEKERTIERLKEQRDR----------DEREKQEEIDNYKKDLKDLKE 631
+ TTL+ A+ + L Q + + E ++ K+ +DLK
Sbjct: 1092 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1151
Query: 632 KVSLLQGD------LSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIA---LEQKKEEC 682
L D L E++AS E+ S ++ G K + K LE+ LE + +
Sbjct: 1152 LYDSLIKDHEKLELLHERQAS-----EYESLISKHGTLKSAH-KNLEVEHRDLEDRYNQL 1205
Query: 683 LKMESQLK-----------------KAHEA-ALEARASPEMSDRIQH------------- 711
LK + QL+ K HE A E + +DR+ H
Sbjct: 1206 LKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ 1265
Query: 712 -----LEREITRYKDESSKAQAEVDRLLEILKEVE---NEKNDKDKKIAELERQVKDQNK 763
L+ + K E ++ +AE +L E ++++ + N++ + +++L+ ++++N+
Sbjct: 1266 TDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENR 1325
Query: 764 KVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRE 820
+L + Q ++ +LE+ +D + +Q D L + + E+LEE + +
Sbjct: 1326 ---HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1379
Score = 65.1 bits (157), Expect = 3e-10
Identities = 98/436 (22%), Positives = 196/436 (44%), Gaps = 57/436 (13%)
Query: 168 LRKDVEVKESKLSSSMNSIK--TFWSPELKKERALRKDEASKITIWKEQYRVVQ------ 219
L+K +E+KE K+++ ++ T ++ +L++E K + +++ R+VQ
Sbjct: 965 LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPIS 1024
Query: 220 -EENQHMQMTIQALQDELRIQRDL------NQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
E+N+ + + + ++ L+++ L N Q + + + E N Q
Sbjct: 1025 GEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQIL 1084
Query: 273 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
+RQ L TL+ +++ + TLN++ S+ M Q+ L + + ++E
Sbjct: 1085 ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL-----MNQNAQLLIQQSSLENEN 1139
Query: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
+ E E L+SL + K++ L E +H R +++ ++L + S
Sbjct: 1140 ESVIKERE----DLKSLYDSLIKDHEKL-ELLHER-----QASEYESLISKHGTLKSAHK 1189
Query: 393 SMERGLRDLEEEI-QMLKSNGALSTEER-----EEEM----KQMEVYRSHSKFMKNKIGQ 442
++E RDLE+ Q+LK G L E+ +E+M K E + K + + +
Sbjct: 1190 NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1249
Query: 443 VKQELSR--KDTELLALQTK-LETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVD-- 497
+ S+ K+TE+L K L++L N + +E L + Q+ I T+++
Sbjct: 1250 LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQ 1309
Query: 498 -----ALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKER----KVNVL 548
L+ LEE+ L QIQ + + T + + KD+ V++R K+N L
Sbjct: 1310 CELLSQLKGNLEEENRHL---LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1366
Query: 549 QKKIENLQEQLRDKEK 564
+++ E L+E++ D+ K
Sbjct: 1367 RRQKEKLEEKIMDQYK 1382
Score = 32.0 bits (71), Expect = 3.3
Identities = 40/206 (19%), Positives = 85/206 (41%), Gaps = 33/206 (16%)
Query: 880 HLTNLRAERRKHLEEVLEMKQE-------ALLAAISEKDANIALLELSSSKKKTQEEVAA 932
HL L ER +H E ++E+ +E ++ ++ ++ + S++ E+A
Sbjct: 196 HLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELAD 255
Query: 933 LKREKDRLVQQLKQQT-----------QNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQI 981
K + RL Q+L+++T Q ++L E+ + S + ++ D +
Sbjct: 256 AKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL 315
Query: 982 IQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTR 1041
+ + +D+ S++ Y L HD + Y ++ +N++ T+
Sbjct: 316 REKAVRVDKLESEVSRYKERL----HDIE-----------FYKARVEELKEDNQVLLETK 360
Query: 1042 GQLQDELEKGERDNAELQEFANAILQ 1067
L+D+LE + +L E LQ
Sbjct: 361 TMLEDQLEGTRARSDKLHELEKENLQ 386
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 135 bits (341), Expect = 2e-31
Identities = 206/902 (22%), Positives = 374/902 (41%), Gaps = 149/902 (16%)
Query: 156 TQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFW--SPELKKERA-LRKDEASKITIWK 212
+++ ++ +EN L K VE+ E+++ S++ S +L KE+A L K + +
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550
Query: 213 EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
Q +++++EN+H+ T+ +L+ +I + E V ++ +EN + LH
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQI---------------SAEARVKDIEKEN-KILHE 594
Query: 273 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
+ + +L +IE +K+ IKK LE + KG
Sbjct: 595 SIKETSSKLS-----------KIEFEKR-------QIKKELEHYKEKG------------ 624
Query: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
R E E +HHLE KEN +L++++ K IE + + S
Sbjct: 625 -ERAEELENELHHLE-------KENELLQKKI----------TNLKITCEKIEALEQENS 666
Query: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT 452
+ER R L++ + K N E E+E Q++ + + +N + L
Sbjct: 667 ELERENRKLKKTLDSFK-NLTFQLESLEKENSQLD--EENLELRRNV-----ESLKCASM 718
Query: 453 ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 512
++ LQ + + L ++ K+ +E+LK S K +R + +D RL++ NK
Sbjct: 719 KMAQLQLENKELESEKEQLKKGLELLKASFK-KTERLEVSYQGLDIENQRLQKTLENSNK 777
Query: 513 KTKQ----IQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSS 568
K +Q +QD+ E T + +LK + +++ L+K+ ++L+++ EK
Sbjct: 778 KIQQLESELQDLEMENQTLQKNLEELK----ISSKRLEQLEKENKSLEQETSQLEKDKKQ 833
Query: 569 LKERVKSLQADTTNTDTAL--------------TTLEEALAEKERTIERLKE-QRDRDER 613
L++ K L+ DT L TL + + + + RLKE +++ E
Sbjct: 834 LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKEL 893
Query: 614 EKQEEID-----NYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRL 668
K+ ID ++DL K K + DL + L + + L D R
Sbjct: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRY 953
Query: 669 KTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKD--ESSKA 726
K LE K E LK ++K+ AALEAR E ++ Q L +E+ K E+ K
Sbjct: 954 K----LLESKLESTLKKSLEIKEEKIAALEARLE-ESTNYNQQLRQELKTVKKNYEALKQ 1008
Query: 727 QAEVDRLLEILKEVENEKNDKDKKIAELERQ---VKDQNKKVANLKHKEQVEKKKSAQML 783
+ + +R+++ + E N +++ E R+ VKD+ +V Q EK+ L
Sbjct: 1009 RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL 1068
Query: 784 EEARRREDNLNDSSQQLQD---SLRKKDDRIEELEEALR--------ESVQITAEREMVL 832
++ + +NL LQ SL++++ ++ L+ +S + + +L
Sbjct: 1069 KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLL 1128
Query: 833 AQEESARTNAEKQVEE------LLMAMEKVKQELESMKAKLSSTQQSLAEKETHL----T 882
Q+ S E ++E L ++ K ++LE + + +S +SL K L
Sbjct: 1129 IQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHK 1188
Query: 883 NLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSK----KKTQEEVAA----LK 934
NL E R LE + LL + + +L++ K K E VAA L
Sbjct: 1189 NLEVEHRD-----LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1243
Query: 935 REKDRLVQQLKQQTQNRMKLMADNYE-DDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRS 993
E DRL Q + L D+ +S QT + ++ + +LD +
Sbjct: 1244 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1303
Query: 994 KL 995
KL
Sbjct: 1304 KL 1305
Score = 132 bits (331), Expect = 2e-30
Identities = 202/903 (22%), Positives = 393/903 (43%), Gaps = 82/903 (9%)
Query: 216 RVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTE--ENFQRLHAE 273
R++ E ++H + I EL +RD F +SS PC + + E+ Q L E
Sbjct: 199 RLIDERDEHSETII-----ELSEERD-GLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE 252
Query: 274 HERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERT 333
++ LR+ LEE ++ KQ L + +K+L + + A++ +
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL 312
Query: 334 RRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISS 393
L E + V LES + + ++ + R E D+ +T++E + +
Sbjct: 313 DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 394 MERGLRDLEEE----------IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQV 443
L +LE+E ++M + EE EE +E+ + S +G
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE 432
Query: 444 KQELSRKDTELLALQTKLETLTNQFSDSK-QHIEVLKESL--TAKEQRAAILQTEVDALR 500
+++SR A Q L N+ + S+ +E+ +SL T +E R + E +A +
Sbjct: 433 LEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASK 492
Query: 501 -LRLEEKETMLNKKTKQIQ-DMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQ 558
L++E++ L+KK + ++ ++ +EK + + KD++ K + ++ EN + Q
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 559 LRDKEKQMSSLKERVKSL-QADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQE 617
++ E++ L + V SL Q + + + +E+ +I+ + + E EK++
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612
Query: 618 EIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLK-TLE--IA 674
KK+L+ KEK G+ +E+ + L E + L KK + LK T E A
Sbjct: 613 ----IKKELEHYKEK-----GERAEELENELHHLEKENELLQ---KKITNLKITCEKIEA 660
Query: 675 LEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLL 734
LEQ+ E + +LKK + + ++ +++ LE+E ++ +E+ + + V+ L
Sbjct: 661 LEQENSELERENRKLKKTLD------SFKNLTFQLESLEKENSQLDEENLELRRNVESLK 714
Query: 735 EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRE--DN 792
++ + + + +E E+ K A+ K E++E +E R ++ +N
Sbjct: 715 CASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLEN 774
Query: 793 LNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMA 852
N QQL+ L+ + + L++ L E ++I+++R L Q E + E++ +L
Sbjct: 775 SNKKIQQLESELQDLEMENQTLQKNL-EELKISSKR---LEQLEKENKSLEQETSQLEKD 830
Query: 853 MEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV------------LEMKQ 900
+++++E + ++ + +L E + NL E + +E+ LE +
Sbjct: 831 KKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
Query: 901 EALL--AAISEKDANIALLELSSSKKKTQE----------EVAALKREKDRLVQQLKQQT 948
+ L+ A I K +L S K KTQ+ E+ + K+RL+ +Q T
Sbjct: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD-EQST 949
Query: 949 QNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHD 1008
+R KL+ E KS + ++ + Q R +LK + L
Sbjct: 950 DDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1009
Query: 1009 RDPLILRGLTPPASYNLDDDQAAWENELQKMTRG--QLQDELEKGERDNAELQEFANAIL 1066
+D + +PP S + WE E Q+ TR +++D L + ER+NA LQ A+
Sbjct: 1010 QDEERMVQSSPPIS----GEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK 1065
Query: 1067 QQI 1069
Q+
Sbjct: 1066 TQL 1068
Score = 118 bits (296), Expect = 3e-26
Identities = 213/1043 (20%), Positives = 429/1043 (41%), Gaps = 184/1043 (17%)
Query: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSI--KTFWSPELKKERALRKDEASKITIW 211
++ +LK + +EN L D ++++ K +L+ E + K+ I +
Sbjct: 284 MEIELKRLQQENMNLLSDAR-SARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFY 342
Query: 212 KEQYRVVQEENQHMQMTIQALQDEL---------------------------RIQRDLNQ 244
K + ++E+NQ + T L+D+L ++RD+++
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDR 402
Query: 245 L---------------------------FQQDSSSRTGEPCVA----------ELTEENF 267
++ + SRT E A ELT
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 462
Query: 268 QRLHAEHERQAKELFLLRKTLEEME------LRIETQKQTLNARDESIKKLLEMLQSKGL 321
+L E++ K + LR T++ +E L++E + Q L+ + E ++ E++Q K
Sbjct: 463 LKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN--EIVQEKQS 520
Query: 322 SAKATEEDHERTRRLAEAEMHVHHLESLLEQK----EKENSMLREEMHRRFENAPDSA-- 375
+ + A+ E + L E++ E+EN L + + + + SA
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 376 -------KTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV 428
+ K L I+ SK+S +E R +++E++ K G EE E E+ +E
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE-RAEELENELHHLE- 638
Query: 429 YRSHSKFMKNKIGQVK------QELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESL 482
++ ++ KI +K + L ++++EL KL+ + F + +E L++
Sbjct: 639 --KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN 696
Query: 483 TAKEQRAAILQTEVDALR--------LRLEEKETMLNKKTKQIQD-----MAEEKGTQAG 529
+ ++ L+ V++L+ L+LE KE L + +Q++ A K T+
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKE--LESEKEQLKKGLELLKASFKKTERL 754
Query: 530 EI---------HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLK---ERVKSLQ 577
E+ L+ L+ +K+ L+ ++++L+ + + +K + LK +R++ L+
Sbjct: 755 EVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLE 814
Query: 578 ADTTNTDTALTTLEEALAEKERTIERLKEQ---RDRDEREKQEEIDNYKKDLKDLKEKVS 634
+ + + + LE+ + E+ +RL++Q +D E +I N +K+ K L +++
Sbjct: 815 KENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI- 873
Query: 635 LLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHE 694
G E L +L++ L L TL L +K + +M + L+K
Sbjct: 874 ---GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 695 AALEARASPEMSDRIQHLEREI-TRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAE 753
+ + E R+ H E+ RYK SK ++ + + LEI K++KIA
Sbjct: 931 ELEKIGLNKE---RLLHDEQSTDDRYKLLESKLESTLKKSLEI----------KEEKIAA 977
Query: 754 LERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEE 813
LE ++++ L+ + + KK + + R+ E+ + SS + K + E
Sbjct: 978 LEARLEESTNYNQQLRQELKTVKKNYEAL--KQRQDEERMVQSSPPISGEDNKWE---RE 1032
Query: 814 LEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQS 873
+E RE +++ + ++ + +A AEKQ L +++++ + +++A++ + Q+
Sbjct: 1033 SQETTRELLKV--KDRLIEVERNNATLQAEKQA--LKTQLKQLETQNNNLQAQILALQRQ 1088
Query: 874 LAEKETHLTNLRAERRKHLEEVLEMKQEALLA-AISEKDANIALLELSSSKKKTQEEVAA 932
+ T L+ + K L+++ L + + S + N LL SS + E V
Sbjct: 1089 TVSLQEQNTTLQTQNAK-----LQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK 1143
Query: 933 LKREKDRLVQQLKQQTQNRMKL---MADNYED-----DHFKSSHSN-QTNHKPSPDQIIQ 983
+ + L L + + L A YE KS+H N + H+ D+ Q
Sbjct: 1144 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1203
Query: 984 PLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGL---TPPASYNLDDDQAAWENELQKMT 1040
L + Q K+ L +++ ++L T A Y + EN+ T
Sbjct: 1204 LLKQKGQLEDLEKM-------LKVEQEKMLLENKNHETVAAEYK----KLCGENDRLNHT 1252
Query: 1041 RGQLQDELEKGERDNAELQEFAN 1063
QL E E + D+ L+ N
Sbjct: 1253 YSQLLKETEVLQTDHKNLKSLLN 1275
Score = 111 bits (278), Expect = 3e-24
Identities = 173/776 (22%), Positives = 336/776 (43%), Gaps = 134/776 (17%)
Query: 153 DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 212
+L+ +L + +EN+LL+K + + L + I+ + ER RK + + +
Sbjct: 629 ELENELHHLEKENELLQKKI----TNLKITCEKIEALEQENSELERENRKLKKTLDSFKN 684
Query: 213 EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
+++ E ++ Q+ ++ L ++R++ L + +A+L EN + L +
Sbjct: 685 LTFQLESLEKENSQLD----EENLELRRNVESL-------KCASMKMAQLQLEN-KELES 732
Query: 273 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
E E+ K L LL+ + ++ E R+E Q L+ ++ ++K LE K ++ +D E
Sbjct: 733 EKEQLKKGLELLKASFKKTE-RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 333 TRRLAEAEMHVHHLESL-LEQKEKENSMLREEMHRRFENAPDSAK-TKALQTVIEMKDS- 389
+ + + + S LEQ EKEN L +E + ++ K K L+ E+KD+
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 390 ------KISSMERGLRDLEEEIQMLKSNGALSTEEREE----------EMKQMEVYRSHS 433
KI ++E+ + L +EI + K + E +E ++K + R
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL 911
Query: 434 KFMKNKIGQVKQELSRKDTELLALQTKLETLTN--QFSDSKQHI------EVLKESLTAK 485
K K Q+ +L + EL + E L + Q +D + + LK+SL K
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIK 971
Query: 486 EQRAAILQTEVDAL-----RLRLEEKETMLNKKT-KQIQD---MAEEKGTQAGEIHD--- 533
E++ A L+ ++ +LR E K N + KQ QD M + +GE +
Sbjct: 972 EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1031
Query: 534 -----LKDMLDVKERKVNV------LQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN 582
+++L VK+R + V LQ + + L+ QL+ E Q ++L+ ++ +LQ T +
Sbjct: 1032 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1091
Query: 583 TDTALTTLEEALAEKERTIERLKEQRDR----------DEREKQEEIDNYKKDLKDLKEK 632
TTL+ A+ + L Q + + E ++ K+ +DLK
Sbjct: 1092 LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSL 1151
Query: 633 VSLLQGD------LSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIA---LEQKKEECL 683
L D L E++AS E+ S ++ G K + K LE+ LE + + L
Sbjct: 1152 YDSLIKDHEKLELLHERQAS-----EYESLISKHGTLKSAH-KNLEVEHRDLEDRYNQLL 1205
Query: 684 KMESQLK-----------------KAHEA-ALEARASPEMSDRIQH-------------- 711
K + QL+ K HE A E + +DR+ H
Sbjct: 1206 KQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT 1265
Query: 712 ----LEREITRYKDESSKAQAEVDRLLEILKEVE---NEKNDKDKKIAELERQVKDQNKK 764
L+ + K E ++ +AE +L E ++++ + N++ + +++L+ ++++N+
Sbjct: 1266 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENR- 1324
Query: 765 VANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRE 820
+L + Q ++ +LE+ +D + +Q D L + + E+LEE + +
Sbjct: 1325 --HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1378
Score = 65.5 bits (158), Expect = 3e-10
Identities = 102/459 (22%), Positives = 206/459 (44%), Gaps = 63/459 (13%)
Query: 145 QARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIK--TFWSPELKKERALRK 202
Q+ D+ L+++L+ L+ K +E+KE K+++ ++ T ++ +L++E K
Sbjct: 947 QSTDDRYKLLESKLESTLK------KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVK 1000
Query: 203 DEASKITIWKEQYRVVQ-------EENQHMQMTIQALQDELRIQRDL------NQLFQQD 249
+ +++ R+VQ E+N+ + + + ++ L+++ L N Q +
Sbjct: 1001 KNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAE 1060
Query: 250 SSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESI 309
+ + E N Q +RQ L TL+ +++ + TLN++ S+
Sbjct: 1061 KQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL 1120
Query: 310 KKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFE 369
M Q+ L + + ++E + E E L+SL + K++ L E +H R
Sbjct: 1121 -----MNQNAQLLIQQSSLENENESVIKERE----DLKSLYDSLIKDHEKL-ELLHER-- 1168
Query: 370 NAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEI-QMLKSNGALSTEER-----EEEM 423
+++ ++L + S ++E RDLE+ Q+LK G L E+ +E+M
Sbjct: 1169 ---QASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM 1225
Query: 424 ----KQMEVYRSHSKFMKNKIGQVKQELSR--KDTELLALQTK-LETLTNQFSDSKQHIE 476
K E + K + + ++ S+ K+TE+L K L++L N + +E
Sbjct: 1226 LLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1285
Query: 477 VLKESLTAKEQRAAILQTEVD-------ALRLRLEEKETMLNKKTKQIQDMAEEKGTQAG 529
L + Q+ I T+++ L+ LEE+ L QIQ + + T
Sbjct: 1286 AEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHL---LDQIQTLMLQNRTLLE 1342
Query: 530 EIHDLKDMLDVKER----KVNVLQKKIENLQEQLRDKEK 564
+ + KD+ V++R K+N L+++ E L+E++ D+ K
Sbjct: 1343 QNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1381
Score = 32.0 bits (71), Expect = 3.3
Identities = 40/206 (19%), Positives = 85/206 (41%), Gaps = 33/206 (16%)
Query: 880 HLTNLRAERRKHLEEVLEMKQE-------ALLAAISEKDANIALLELSSSKKKTQEEVAA 932
HL L ER +H E ++E+ +E ++ ++ ++ + S++ E+A
Sbjct: 196 HLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELAD 255
Query: 933 LKREKDRLVQQLKQQT-----------QNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQI 981
K + RL Q+L+++T Q ++L E+ + S + ++ D +
Sbjct: 256 AKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL 315
Query: 982 IQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTR 1041
+ + +D+ S++ Y L HD + Y ++ +N++ T+
Sbjct: 316 REKAVRVDKLESEVSRYKERL----HDIE-----------FYKARVEELKEDNQVLLETK 360
Query: 1042 GQLQDELEKGERDNAELQEFANAILQ 1067
L+D+LE + +L E LQ
Sbjct: 361 TMLEDQLEGTRARSDKLHELEKENLQ 386
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 135 bits (339), Expect = 3e-31
Identities = 221/987 (22%), Positives = 426/987 (43%), Gaps = 143/987 (14%)
Query: 151 IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSP-ELKKERALRKDEA---- 205
I +LQ ++KE EN L +E ++ K+ S +N +K S L++ + + K EA
Sbjct: 1769 IHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIEL 1828
Query: 206 -SKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQ--DSSSRTGEPCVAEL 262
+ K++ + E+ ++ Q L + LN + D SSR
Sbjct: 1829 EKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSR--------- 1879
Query: 263 TEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLS 322
E+ A+ KE FL +E RI ++K ++ ++ LE++Q++ L
Sbjct: 1880 --EDIGDNVAKVNDSWKERFL---DVENELSRIRSEKASIEHEALYLEADLEVVQTEKL- 1933
Query: 323 AKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQT 382
E+D+E +++ + LE L E + LR E+ S KT AL
Sbjct: 1934 --CLEKDNENKQKV------IVCLEEELSVVTSERNQLRGELDTM------SKKTTALDQ 1979
Query: 383 VIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSH-SKFMKNKIG 441
+ E K +E + IQ+ ++ E +E+ + ++ S S+ +K+K
Sbjct: 1980 LSEKMKEKTQELESHQSECLHCIQVAEA-------EVKEKTELLQTLSSDVSELLKDKTH 2032
Query: 442 -QVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALR 500
Q K + KD++ L+L TK E L NQ + + E+L + E ++L+
Sbjct: 2033 LQEKLQSLEKDSQALSL-TKCE-LENQIAQLNKEKELLVK--------------ESESLQ 2076
Query: 501 LRLEEKETMLNKKTKQIQDMAEEKGTQA-------GEIHDLKDMLDVKERKVNVLQKKIE 553
RL E + +K ++ EKG A E+H L+ ++ ++ +KK
Sbjct: 2077 ARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQL 2136
Query: 554 NLQEQLRDKEKQMSSLKERV----KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD 609
++ E+L+++E++ SLK++V + LQ N + + E + AE +E LK Q +
Sbjct: 2137 HIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAE----VETLKTQIE 2192
Query: 610 RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLK 669
E + ++ DL L+ + L + EK+ L +L + SS S +K+
Sbjct: 2193 ----EMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQ--- 2245
Query: 670 TLEIALEQKKEECLKM-ESQLKKAHEAALEARASPEMSDRIQHL------EREITRYKDE 722
EI ++++ + ++M ++QLK+ +EA E+ + E R E
Sbjct: 2246 -AEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE 2304
Query: 723 SSKAQAEVDR-----LLEILKEVENEKNDKDKKIAELERQVKDQNK-------KVANLKH 770
+A+ E D +L+ LKE E+ + ++ LER+++ + N K
Sbjct: 2305 KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKG 2364
Query: 771 KEQVEKKKSAQMLEEARRRE---DNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAE 827
+ + K K M + R E + + L + L+K+ +RI ELE I +
Sbjct: 2365 EVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE-------IINSS 2417
Query: 828 REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 887
E +L ++E + +++ + ++ +EL A L + Q++ KE +L++
Sbjct: 2418 FENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSS---- 2473
Query: 888 RRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKRE-KDRLVQQLKQ 946
E LE+++ LL + E N +L+ S + + E K E KD + +LK
Sbjct: 2474 ----QVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKN 2529
Query: 947 QTQNRMKLMA--DNYEDDH--FKSSHSNQTNHKPSPDQIIQPLLELDQN-RSKLKLYIGH 1001
Q Q++ +L++ E +H +K + N +Q IQ L + + + L++
Sbjct: 2530 QIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSS 2589
Query: 1002 LTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMT--RGQLQDELEKGERDNAELQ 1059
L ++ + + D+ ++ ++ KMT +LQ E+ + + AELQ
Sbjct: 2590 YKNLENELELTKM-------------DKMSFVEKVNKMTAKETELQREMHEMAQKTAELQ 2636
Query: 1060 EFANAILQQIADHCPDILEQVVNALEE 1086
E + ++A +LE++ ++ ++
Sbjct: 2637 EELSGEKNRLAGELQLLLEEIKSSKDQ 2663
Score = 122 bits (306), Expect = 2e-27
Identities = 203/987 (20%), Positives = 399/987 (40%), Gaps = 158/987 (16%)
Query: 151 IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITI 210
I L+ +LK E + ++ + + L+ K F +P + SK
Sbjct: 111 IEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYY----SGSKYED 166
Query: 211 WKEQYRVVQEENQHMQMTIQALQDELRIQ---------RDLNQLFQQDSSSRTGEPCVAE 261
KE+Y EE + ++ ++ALQ + Q RD+ + S +
Sbjct: 167 LKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPS 226
Query: 262 LTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR---DESIKKLLEML-- 316
N QR + A F + + ++ K+ N+ + S LL+ L
Sbjct: 227 HLSSNSQRTPIRRDFSA-SYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKA 285
Query: 317 QSKGLSAKATE-----EDHER-----TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHR 366
Q++ L K E + HE+ + E ++ + + L +KEK + R+E+ R
Sbjct: 286 QNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVR 345
Query: 367 RFENAPDSAKTKALQTVIEMKDSKIS---------------SMERGLRDLEEEIQMLKSN 411
D A TK T +E K K++ S+E+ +++ E+E Q S
Sbjct: 346 TTAQY-DQASTK--YTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSR 402
Query: 412 GALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDS 471
S + ++E QM+ ++ QEL + LQ +L+ LT+
Sbjct: 403 QQRSFQTLDQECIQMK-------------ARLTQELQQAKNMHNVLQAELDKLTSVKQQL 449
Query: 472 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 531
+ ++E K+ L EQ Q + + LR +EE + N + A E E+
Sbjct: 450 ENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAEL 509
Query: 532 HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE--RVKSLQADTTNTDTALTT 589
++K L+ + ++ K + + LRD +++++ + ++ L+ + +
Sbjct: 510 KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC 569
Query: 590 LEEALAEKERTIERLKEQRDRDEREKQ---EEIDNYKKDLKDLKEKVSLLQGDLSEKEAS 646
++ L ++E IE+L ++ + E+E + ++ KK+ ++LKE+ +L SE E
Sbjct: 570 SQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKL 629
Query: 647 LLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMES-------QLKKAHE----- 694
L ++ +L S ++ LKT +I + E +E +++ H
Sbjct: 630 LTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSK 689
Query: 695 ---------AALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKN 745
A +E + E SD Q ++EI ++S+ +V+ L L+ + NE
Sbjct: 690 SVEVETQKLAYMELQQKAEFSD--QKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIM 747
Query: 746 DKDKKIAELERQ---VKDQNKK-----VANLKHKE------------------------- 772
DKD+ +L + ++D K V N H+
Sbjct: 748 DKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSM 807
Query: 773 -------QVEKKKSAQMLEEARRREDNLN---DSSQQLQDSLRKKDDRI----EELEEAL 818
++E +S + + R D+L +S +Q+ L+K+ + + E+EE L
Sbjct: 808 PSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENL 867
Query: 819 RESVQI-------TAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ 871
++ Q+ T++R L ++ SA N V E L A+E ++EL+ + K+ + Q
Sbjct: 868 MKAEQMHQSFVAETSQRISKLQEDTSAHQNV---VAETLSALENKEKELQLLNDKVETEQ 924
Query: 872 QSLAE--KETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEE 929
+ E K HL + + L E L ++++ + + IS I EL+ +E
Sbjct: 925 AEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIE--ELTQENGTLKEI 982
Query: 930 VAALKREKDRLVQQLK------QQTQNRMKLMADNYEDDH-FKSSHSNQTNHKPSPDQII 982
A+L +EK L+Q+ + + + + ++D Y+ + +T + + + +
Sbjct: 983 NASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGN--AYEDLS 1040
Query: 983 QPLLELDQNRSKLKLYIGHLTTLCHDR 1009
Q + SKL+ + T+LC +R
Sbjct: 1041 QKYKAAQEKNSKLECLLNECTSLCENR 1067
Score = 115 bits (289), Expect = 2e-25
Identities = 177/890 (19%), Positives = 390/890 (43%), Gaps = 123/890 (13%)
Query: 152 MDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITI- 210
++L+ + E+ +EN L + +E + ++T S L + + D++S+ I
Sbjct: 1826 IELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVET--SEGLNSDLEMHADKSSREDIG 1883
Query: 211 ---------WKEQYRVVQEENQHMQMTIQALQDE-LRIQRDLNQLFQQDSSSRTGEPCVA 260
WKE++ V+ E ++ +++ E L ++ DL + +T + C+
Sbjct: 1884 DNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVV-------QTEKLCL- 1935
Query: 261 ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKG 320
E EN Q++ E + + T E +LR E T++ + ++ +L E ++ K
Sbjct: 1936 EKDNENKQKVIVCLEEELSVV-----TSERNQLRGELD--TMSKKTTALDQLSEKMKEKT 1988
Query: 321 LSAKATEEDHERTRRLAEAEMH-----VHHLESLLEQKEKENSMLREEMHRRFENAPDSA 375
++ + + ++AEAE+ + L S + + K+ + L+E++ +++ +
Sbjct: 1989 QELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALS 2048
Query: 376 KTKA--------LQTVIEMKDSKISSMERGLRDLE-EEIQMLKSNGALSTEEREEEMK-- 424
TK L E+ + S++ L + + E++ + K+ A E+ E ++
Sbjct: 2049 LTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLS 2108
Query: 425 --QMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESL 482
Q EV++ ++ I +++ + + + L + KL+ + K +E L+ L
Sbjct: 2109 STQEEVHQ-----LRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLEREL 2163
Query: 483 TAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKE 542
E+ ++ + + + +E +T + + + ++ + T E +L + K+
Sbjct: 2164 QMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ 2223
Query: 543 RKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE 602
+++ L K + + + L +KE+ +KE K+ N L AL + ++
Sbjct: 2224 GQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMK 2283
Query: 603 RLKEQRD---RDEREKQEEIDNYKKDLK-DLKEKVSLLQGDLSEKEASLLDLKEHASSLA 658
++ D +E + + I+ + L+ D K+++ +LQ L + + HA L
Sbjct: 2284 ATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ--------QLKESEHHADLL- 2334
Query: 659 SSGLKKDSRLKTLEIALE--QKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREI 716
R++ LE LE + +E +E++ K L+A+ M+ ++ LE ++
Sbjct: 2335 ------KGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIE-GMTQSLRGLELDV 2387
Query: 717 TRYKDE----SSKAQAEVDRLLE----------ILKEVENEKNDKDKK----IAELERQV 758
+ E +++ Q E +R+ E IL+E E EK +K + L+ Q+
Sbjct: 2388 VTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQL 2447
Query: 759 KDQNKKVANL-------KHKEQ----------VEKKKSAQMLEEARRR----EDNLNDSS 797
K+ N++VA L K KEQ +EK + Q L+EA+ + ++N
Sbjct: 2448 KELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLI 2507
Query: 798 QQLQD---SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAME 854
Q+++D L KKD+ I L+ +++ Q+ ++ L+Q E ++Q EL
Sbjct: 2508 QEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSK----LSQVEGEHQLWKEQNLELRNLTV 2563
Query: 855 KVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI 914
+++Q+++ +++K +S Q +L ++ NL E + + ++ E +
Sbjct: 2564 ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQR 2623
Query: 915 ALLELSSSKKKTQEEVAALKR----EKDRLVQQLKQQTQNRMKLMADNYE 960
+ E++ + QEE++ K E L++++K +L +N E
Sbjct: 2624 EMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSE 2673
Score = 114 bits (286), Expect = 4e-25
Identities = 154/768 (20%), Positives = 331/768 (43%), Gaps = 112/768 (14%)
Query: 154 LQTQLKEVLR--------------ENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERA 199
L+TQ++E+ R E + L K ++ K+ +LS + +F S +KE+A
Sbjct: 2187 LKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQA 2246
Query: 200 ---LRKDEASKITIWKEQYRVVQE-------ENQHMQMTIQAL----QDELRIQRDLNQL 245
++++ + + + + Q + + E + + M+ T Q+L ++E +++ + +L
Sbjct: 2247 EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKL 2306
Query: 246 FQQDSSSRTGEPCVAELTEENFQR---LHAEHERQAKELFLLRKTLEEMELRIETQK--- 299
+ + + CV + +E+ L E +EL + R E L E K
Sbjct: 2307 RARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEV 2366
Query: 300 QTLNARDESIKKLLEMLQSKGLSAKATEED-----HERTRRLAEAEMHVHHLESLLEQKE 354
+TL A+ E + + L L+ ++ ++ +E+ + R++E E+ E++L++KE
Sbjct: 2367 ETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKE 2426
Query: 355 KENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGAL 414
+E ++E+ T +EM ++ L++L E + L ++
Sbjct: 2427 QEKVQMKEKS----------------STAMEM-------LQTQLKELNERVAALHNDQEA 2463
Query: 415 STEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH 474
+ + Q+E ++ + Q+ Q L + LQ+ + L + D KQ
Sbjct: 2464 CKAKEQNLSSQVEC-------LELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQK 2516
Query: 475 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDL 534
+E E E+ L+ +++++E +++K + Q++ + Q E+ +L
Sbjct: 2517 LEKKDE--------------EISRLKNQIQDQEQLVSKLS-QVEGEHQLWKEQNLELRNL 2561
Query: 535 KDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEAL 594
L E+K+ VLQ K +LQ+ L + +L+ ++ + D + + +
Sbjct: 2562 TVEL---EQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE 2618
Query: 595 AEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHA 654
E +R + + ++ + E E + +L+ L E++ + L E +LK+
Sbjct: 2619 TELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSL 2678
Query: 655 SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLER 714
+ ++K+ +++ E+ E L++ KK L+ E+ IQ
Sbjct: 2679 DCMHKDQVEKEGKVR------EEIAEYQLRLHEAEKKHQALLLDTNKQYEV--EIQTYRE 2730
Query: 715 EITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANL-KHKEQ 773
++T ++ S + E+D L +E+ N + + EL++ D K V L K E+
Sbjct: 2731 KLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENER 2790
Query: 774 VEKK-----KSAQMLEEAR---RREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQIT 825
+ K KS + LEE + ++E + ++Q+ Q + D +++EL ++E
Sbjct: 2791 AQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKEL---- 2846
Query: 826 AEREMVLAQEESARTNAEKQVEELLM--AMEKVKQELESMKAKLSSTQ 871
+E + + + A +K L+ +EK K+ LE+ A L S Q
Sbjct: 2847 --KETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQ 2892
Score = 99.8 bits (247), Expect = 1e-20
Identities = 147/725 (20%), Positives = 293/725 (40%), Gaps = 83/725 (11%)
Query: 291 MELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL 350
M +E K+ L R +++K+ E+ +G K +E +R +L E + + +
Sbjct: 1 MSWALEEWKEGLPTR--ALQKIQEL---EGQLDKLKKEKQQRQFQLDSLEAALQKQKQKV 55
Query: 351 EQKEKENSMLREEMHRRFENAPDSAKTKA-LQTVIEMKDSKISSMERGLRDLEEEIQMLK 409
E ++ E + L+ E R E KTK + +++K+S+++ E L +++I+ L+
Sbjct: 56 ENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLE 115
Query: 410 SN--GALSTEEREEEMKQM---------------------EVYRSHSKF--MKNKIGQVK 444
S ER ++ Q Y S SK+ +K K +
Sbjct: 116 QELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEV 175
Query: 445 QELSRKDTELLALQTK-----LETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDAL 499
+E R + E+ ALQ K L T D +H +E+ + L +
Sbjct: 176 EERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRT 235
Query: 500 RLRLE--------EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKK 551
+R + E+E ++ T QI + + + +LD + + L+ K
Sbjct: 236 PIRRDFSASYFSGEQEVTPSRSTLQIGK--RDANSSFFDNSSSPHLLDQLKAQNQELRNK 293
Query: 552 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRD 611
I L+ +L+ EK+M + + LQ L + L EKE+ + + +++ R
Sbjct: 294 INELELRLQGHEKEMKGQVNKFQELQLQ-------LEKAKVELIEKEKVLNKCRDELVRT 346
Query: 612 EREKQEEIDNY---KKDLKDLKEKVSLLQGDLSEKEASL-LDLKEHASSLASSGLKKDSR 667
+ + Y ++ LK L E +S + + SL +KE ++
Sbjct: 347 TAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRS 406
Query: 668 LKTLEIALEQKKEECLKMESQLKKAH---EAALEARAS--PEMSDRIQHLEREITRYKDE 722
+TL+ Q K + Q K H +A L+ S ++ + ++ ++++ R +
Sbjct: 407 FQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQA 466
Query: 723 SSKAQAEVDRLLEILKEVENEKN-------DKDKKIAELERQVKDQNKKVANLKHKEQVE 775
+Q + + L ++E++ E N K +++ LE ++K+ + + ++ +
Sbjct: 467 FQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEM 526
Query: 776 KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE 835
K K+ R ++ +N L +L K + +LE+ S + +RE + Q
Sbjct: 527 KAKNTSQETMLRDLQEKINQQENSL--TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQL 584
Query: 836 ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERR------ 889
+ EK+ + LL A+E K+E E +K + + +E E LT + +E+
Sbjct: 585 NDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKI 644
Query: 890 KHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQ 949
HLE L+ +Q I + N + L ++ E+ L D +++ Q
Sbjct: 645 NHLETCLKTQQ------IKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKL 698
Query: 950 NRMKL 954
M+L
Sbjct: 699 AYMEL 703
Score = 98.6 bits (244), Expect = 3e-20
Identities = 132/530 (24%), Positives = 236/530 (44%), Gaps = 75/530 (14%)
Query: 147 RDNTIMD-LQTQLKEVLRENDLLRKDVEV---KESKLSSSMNSIKTFWSPELKKERALRK 202
+ +T M+ LQTQLKE+ L D E KE LSS + + EL+K + L+
Sbjct: 2435 KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECL------ELEKAQLLQG 2488
Query: 203 -DEASKITIWKEQYRVVQEENQHMQMTIQALQD-ELRIQRDLNQLFQQDSSSRTGEPCVA 260
DEA K Y V+Q + IQ ++D + ++++ ++ + + + E V+
Sbjct: 2489 LDEA------KNNYIVLQSSVNGL---IQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVS 2539
Query: 261 ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKG 320
+L++ + EH+ ++ LR E+E +I Q L +++ S++ LE+LQS
Sbjct: 2540 KLSQ-----VEGEHQLWKEQNLELRNLTVELEQKI----QVLQSKNASLQDTLEVLQS-- 2588
Query: 321 LSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKAL 380
S K E + E T+ + EK N M +E + E + KT L
Sbjct: 2589 -SYKNLENELELTKM------------DKMSFVEKVNKMTAKETELQREMHEMAQKTAEL 2635
Query: 381 QTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKI 440
Q + + ++++ L+ L EEI+ K T E E K ++ K K
Sbjct: 2636 QEELSGEKNRLAGE---LQLLLEEIKSSKDQLKELTLENSELKKSLDCMH---KDQVEKE 2689
Query: 441 GQVKQELSRKDTELLALQTKLETLTNQFSDSKQH---IEVLKESLTAKEQRAAILQTEVD 497
G+V++E++ L + K + L +KQ+ I+ +E LT+KE+ + + E+D
Sbjct: 2690 GKVREEIAEYQLRLHEAEKKHQALL--LDTNKQYEVEIQTYREKLTSKEECLSSQKLEID 2747
Query: 498 ALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE 557
L+ EE L T+ ++++ + K ++ LK + + K+ +L K + L+E
Sbjct: 2748 LLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEE 2807
Query: 558 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQE 617
+ +K++S L + + Q T DT + L + E + T+E EK +
Sbjct: 2808 EKEILQKELSQL-QAAQEKQKTGTVMDTKVDELTTEIKELKETLE-----------EKTK 2855
Query: 618 EIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSR 667
E D Y L L+ + EK +L+ + + L S K+DSR
Sbjct: 2856 EADEYLDKYCSL-----LISHEKLEKAKEMLETQ--VAHLCSQQSKQDSR 2898
Score = 78.6 bits (192), Expect = 3e-14
Identities = 159/880 (18%), Positives = 338/880 (38%), Gaps = 149/880 (16%)
Query: 153 DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 212
DLQ Q +E+++ ++ ++E K S S + K L++D ++ +
Sbjct: 848 DLQKQCEELVQ----IKGEIEENLMKAEQMHQSFVAETSQRISK---LQEDTSAHQNVVA 900
Query: 213 EQYRVVQEENQHMQMT---IQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQR 269
E ++ + + +Q+ ++ Q E++ + N L + L ++
Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 960
Query: 270 LHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEED 329
+ + ++R+ +EL TL+E+ + +K L + ES ++
Sbjct: 961 IISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYID--------------- 1005
Query: 330 HERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDS 389
ER + ++E + +L Q+ +E E++ ++++ A + K L+ ++ S
Sbjct: 1006 -EREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQE--KNSKLECLLNECTS 1062
Query: 390 KISSMERGLRDLEE----EIQMLKSNGALSTEEREEEMKQMEVYRS--------HSKFMK 437
+ + L L+E E Q + A + E + M ++E + + K
Sbjct: 1063 LCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSK 1122
Query: 438 NKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLK-----ESLTAKEQRAAIL 492
++ G +KQE+ E +Q ++ L +++Q ++V+K ++L ++ R ++
Sbjct: 1123 SEAGGLKQEIMTLKEEQNKMQKEVNDL---LQENEQLMKVMKTKHECQNLESEPIRNSVK 1179
Query: 493 QTE--------------------VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 532
+ E +D+ +L + E ML K ++Q+ +EK E+
Sbjct: 1180 ERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQ 1239
Query: 533 DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 592
++ L+ + ++ ++I L++ D E++ S + + Q D + +L T
Sbjct: 1240 TIRGDLETSNLQ-DMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1298
Query: 593 ALAEKERTIERLKEQR---------DRDE-----REKQEEIDNYKKDLKDLKEKVSLLQG 638
L E E+ E L+ ++ R E R+ EE+ ++K L + LL G
Sbjct: 1299 KLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHG 1358
Query: 639 DL-----------------------------------SEKEASL---------LDLKEHA 654
+L S+KE + L L+
Sbjct: 1359 ELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEH 1418
Query: 655 SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLK-------KAHEAALEARASPEMSD 707
L + S++ L+ ++ K E L + + L+ K + LE P +S
Sbjct: 1419 KILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSS 1478
Query: 708 RIQHLEREITRYKDESS-KAQAEVDRLLEILKEVENEKNDKDKKIAEL------ERQVKD 760
++ D S +A E + +L +E + + E+ E +
Sbjct: 1479 SCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTR 1538
Query: 761 QNKKVANLKHKEQVEK-----KKSAQMLEEARRREDNL-NDSSQQLQDSLRKKDDRIEEL 814
+ A K E++E ++S + LEE + + N Q+L+ L + ++ L
Sbjct: 1539 KETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCL 1598
Query: 815 -EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQS 873
++ L E+ Q + V + ES +KQ E+L + +E + +L+ + S
Sbjct: 1599 RKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGI 1658
Query: 874 LAEKETHLTNLRAE-RRKHLEEVLEMKQEALLAAISEKDA 912
E N + ++H E E + + I +KDA
Sbjct: 1659 DTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDA 1698
Score = 75.9 bits (185), Expect = 2e-13
Identities = 187/958 (19%), Positives = 375/958 (39%), Gaps = 172/958 (17%)
Query: 119 ASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESK 178
+ D + EHH+ ++ + +A + + +L+ + E L+E L + + K
Sbjct: 570 SQDLLKKREHHIEQLNDKLSKTEKESKALLSAL-ELKKKEYEELKEEKTLFSCWKSENEK 628
Query: 179 LSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQ---DE 235
L + M S K ++ K + K + E+ R ++ + +++ + I+ L D
Sbjct: 629 LLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDS 688
Query: 236 LRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRI 295
++ + +L + + AE +++ Q+ E E + L +E++E ++
Sbjct: 689 KSVEVETQKLAYMELQQK------AEFSDQKHQK---EIENMCLKTSQLTGQVEDLEHKL 739
Query: 296 ETQKQTLNARDE-------SIKKLLEMLQSKGLSAKATEEDHERT--------------- 333
+ + +D + L ++L+SK S T EDH+R+
Sbjct: 740 QLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL-VTNEDHQRSLLAFDQQPAMHHSFA 798
Query: 334 ------------------------RRLAEAEMHVHHLESLLEQKEK-------------- 355
+ A + V LE LE +++
Sbjct: 799 NIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQ 858
Query: 356 ------ENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLK 409
EN M E+MH+ F A S + LQ + ++ L + E+E+Q+L
Sbjct: 859 IKGEIEENLMKAEQMHQSFV-AETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLL- 916
Query: 410 SNGALSTEERE-EEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLE--TLTN 466
N + TE+ E +E+K+ N + E S K+ +LL+ LE +++
Sbjct: 917 -NDKVETEQAEIQELKK-----------SNHL----LEDSLKELQLLSETLSLEKKEMSS 960
Query: 467 QFSDSKQHIEVL-KESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAE--- 522
S +K+ IE L +E+ T KE A++ Q +++ ++ + E ++++ K I ++++
Sbjct: 961 IISLNKREIEELTQENGTLKEINASLNQEKMNLIQ-KSESFANYIDEREKSISELSDQYK 1019
Query: 523 -------EKGTQAGEIH-DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER-V 573
++ + G + DL + K + L+ + +++ ++ LKE
Sbjct: 1020 QEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1079
Query: 574 KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV 633
K Q T A + + E E + L+ + ++ + E K+++ LKE+
Sbjct: 1080 KEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQ 1139
Query: 634 SLLQ---GDLSEKEASLL-------------------DLKEHASSLASSGLKKDSRLKTL 671
+ +Q DL ++ L+ +KE S K L+
Sbjct: 1140 NKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVK 1199
Query: 672 EIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD 731
EI+L+ + +++E+ L+ L+ + S + + +QH E + R E+S Q
Sbjct: 1200 EISLDSYNAQLVQLEAMLRNKE---LKLQESEKEKECLQH-ELQTIRGDLETSNLQDMQS 1255
Query: 732 RLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQV------EKKKSAQMLE- 784
+ + LK+ E D ++K ++ A+L+ Q E +K ++L+
Sbjct: 1256 QEISGLKDCE---IDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQA 1312
Query: 785 EARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEK 844
E LNDS + + RK + + +L E+ + ++S + E
Sbjct: 1313 EKYELVTELNDSRSECITATRKMAEEVGKL------------LNEVKILNDDSGLLHGE- 1359
Query: 845 QVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALL 904
+ E + E +Q E L+ +S HLT E + H E+ QE L
Sbjct: 1360 -LVEDIPGGEFGEQPNEQHPVSLAPLDES--NSYEHLTLSDKEVQMHFAEL----QEKFL 1412
Query: 905 AAISE-KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYED 961
+ SE K + ++SS + Q V +LK E L L+ + +K M E+
Sbjct: 1413 SLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEE 1470
Score = 65.5 bits (158), Expect = 3e-10
Identities = 109/576 (18%), Positives = 244/576 (42%), Gaps = 47/576 (8%)
Query: 542 ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI 601
E +++ L+K+ + Q QL E + K++V++ + + TN L E E+T
Sbjct: 24 EGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTK 83
Query: 602 ERLKEQRDRDERE---KQEEIDNYKKDLKDLKEKVSLLQGDL--SEKEASLLDL------ 650
+++ + E + ++ ++++ KK ++ L++++ + +L S++ A D+
Sbjct: 84 QKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCN 143
Query: 651 ---KEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSD 707
K + L S S+ + L+ ++ EE ++E+++K AL+A+ + +
Sbjct: 144 TPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVK-----ALQAKKASQTLP 198
Query: 708 RIQHLEREITRYKDESSKAQAEVDRLLEILKEVENE---KNDKDKKIAELERQVKDQNKK 764
+ R+I R++ SS + ++ L + D E++V
Sbjct: 199 QATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRST 258
Query: 765 VANLKHKEQ---VEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKD-------DRIEEL 814
+ K + S +L++ + + L + +L+ L+ + ++ +EL
Sbjct: 259 LQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQEL 318
Query: 815 EEALRESVQITAEREMVL--AQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 872
+ L ++ E+E VL ++E RT A Q ++ ++Q+L+ + LS +Q
Sbjct: 319 QLQLEKAKVELIEKEKVLNKCRDELVRTTA--QYDQASTKYTALEQKLKKLTEDLSCQRQ 376
Query: 873 SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA 932
+ L E+ K +E L +Q + E A L + K V
Sbjct: 377 NAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNV-- 434
Query: 933 LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR 992
L+ E D+L +KQQ +N + + ++ ++ + Q + + +++ + + E+ +
Sbjct: 435 LQAELDKLT-SVKQQLENNL----EEFKQKLCRAEQAFQAS-QIKENELRRSMEEMKKEN 488
Query: 993 SKLKLYIGH-LTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKG 1051
+ LK + +CH L S N ++ A + M R LQ+++ +
Sbjct: 489 NLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR-DLQEKINQQ 547
Query: 1052 ERD-NAELQEFANAILQQIADHCPDILEQVVNALEE 1086
E E + A A L++ D D+L++ + +E+
Sbjct: 548 ENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQ 583
Score = 42.7 bits (99), Expect = 0.002
Identities = 51/236 (21%), Positives = 103/236 (43%), Gaps = 24/236 (10%)
Query: 749 KKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKD 808
+KI ELE Q+ D+ KK E+ +++ LE A +++ ++ + +L++++
Sbjct: 18 QKIQELEGQL-DKLKK-------EKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKREN 69
Query: 809 DRIEELEEALRESVQ-ITAEREMVLAQ---EESARTNAEKQVEELLMAMEKVKQELESMK 864
R+ E+ E+L ++ Q I+ E ++ +Q +E + +KQ+ EK++QEL+ K
Sbjct: 70 QRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQI-------EKLEQELKRCK 122
Query: 865 AKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKK 924
++L +QQ+ + L ++ + + +D + +K
Sbjct: 123 SELERSQQAAQSADVSLNPCNTPQKIF---TTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179
Query: 925 KTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQ 980
+ + EV AL+ +K Q L Q T N + F +H S Q
Sbjct: 180 RLEAEVKALQAKK--ASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQ 233
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.123 0.316
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,094,934
Number of Sequences: 37866
Number of extensions: 1686757
Number of successful extensions: 41056
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 832
Number of HSP's successfully gapped in prelim test: 1599
Number of HSP's that attempted gapping in prelim test: 10996
Number of HSP's gapped (non-prelim): 11419
length of query: 1088
length of database: 18,247,518
effective HSP length: 113
effective length of query: 975
effective length of database: 13,968,660
effective search space: 13619443500
effective search space used: 13619443500
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.