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Search of human proteins with 37595548
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
(1048 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 2127 0.0
gi|19923493 pleckstrin homology domain containing, family A memb... 436 e-122
gi|219689123 pleckstrin homology domain containing, family A mem... 421 e-117
gi|239047795 pleckstrin homology domain containing, family A mem... 325 1e-88
gi|238859653 pleckstrin homology domain containing family A memb... 147 7e-35
gi|238859651 pleckstrin homology domain containing family A memb... 143 7e-34
gi|239755547 PREDICTED: similar to hCG2040524 [Homo sapiens] 112 1e-24
gi|239749985 PREDICTED: hypothetical protein XP_002347262 [Homo ... 112 1e-24
gi|239744296 PREDICTED: hypothetical protein XP_002343091 [Homo ... 112 1e-24
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 74 9e-13
gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Ho... 70 1e-11
gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [... 67 9e-11
gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [... 67 9e-11
gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H... 67 9e-11
gi|24432056 hypothetical protein LOC144717 [Homo sapiens] 66 1e-10
gi|50980301 myosin phosphatase-Rho interacting protein isoform 2... 63 1e-09
gi|50980307 myosin phosphatase-Rho interacting protein isoform 1... 63 1e-09
gi|50234893 pleckstrin homology domain containing, family A (pho... 60 8e-09
gi|31377720 pleckstrin homology domain containing, family A (pho... 60 8e-09
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 60 1e-08
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 60 1e-08
gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 60 1e-08
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 60 1e-08
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 60 1e-08
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 60 1e-08
gi|217416392 pleckstrin homology domain containing, family H (wi... 57 7e-08
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 57 7e-08
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 56 2e-07
gi|4758968 cytohesin 3 [Homo sapiens] 55 3e-07
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens] 55 5e-07
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 2127 bits (5510), Expect = 0.0
Identities = 1048/1048 (100%), Positives = 1048/1048 (100%)
Query: 1 MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPV 60
MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPV
Sbjct: 1 MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPV 60
Query: 61 TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI 120
TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
Sbjct: 61 TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI 120
Query: 121 SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD 180
SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD
Sbjct: 121 SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD 180
Query: 181 SENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLP 240
SENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLP
Sbjct: 181 SENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLP 240
Query: 241 AGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFP 300
AGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFP
Sbjct: 241 AGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFP 300
Query: 301 PRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPD 360
PRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPD
Sbjct: 301 PRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPD 360
Query: 361 DYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDA 420
DYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDA
Sbjct: 361 DYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDA 420
Query: 421 TVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSAR 480
TVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSAR
Sbjct: 421 TVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSAR 480
Query: 481 FERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQ 540
FERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQ
Sbjct: 481 FERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQ 540
Query: 541 NKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIR 600
NKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIR
Sbjct: 541 NKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIR 600
Query: 601 VELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVME 660
VELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVME
Sbjct: 601 VELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVME 660
Query: 661 GLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKP 720
GLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKP
Sbjct: 661 GLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKP 720
Query: 721 GSNEPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTD 780
GSNEPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTD
Sbjct: 721 GSNEPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTD 780
Query: 781 DEVTPSAVVRRNASGLTNGLSSQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKR 840
DEVTPSAVVRRNASGLTNGLSSQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKR
Sbjct: 781 DEVTPSAVVRRNASGLTNGLSSQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKR 840
Query: 841 RSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARL 900
RSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARL
Sbjct: 841 RSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARL 900
Query: 901 RKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAK 960
RKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAK
Sbjct: 901 RKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAK 960
Query: 961 SSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPT 1020
SSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPT
Sbjct: 961 SSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPT 1020
Query: 1021 SPASPAPPANPLSSESPRGADSSYTMRV 1048
SPASPAPPANPLSSESPRGADSSYTMRV
Sbjct: 1021 SPASPAPPANPLSSESPRGADSSYTMRV 1048
>gi|19923493 pleckstrin homology domain containing, family A member 5
isoform 1 [Homo sapiens]
Length = 1116
Score = 436 bits (1122), Expect = e-122
Identities = 346/1087 (31%), Positives = 528/1087 (48%), Gaps = 138/1087 (12%)
Query: 1 MSNKTGGKRPATTNSDIPNHNMVSE--VPPERPSVRATRTARKAVAFGKRSHSMKRNPNA 58
M+++ +RP + ++ N+N+ S+ V P P R +R ++K FGKRS+S+KRNPNA
Sbjct: 109 MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA 168
Query: 59 PVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSD 118
PV + GWL+KQ S+G+K W KRWFVL D CLFYY+DEKEE ILGSI L SF++A + D
Sbjct: 169 PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED 228
Query: 119 NISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEK 178
+I+RK+ FKA H +RTY+F ++ +E E W++AM +AA VQ P ++ +K
Sbjct: 229 HINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRV---------DK 279
Query: 179 PDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKE----PPV 234
SEN P + + P H L KPE + + + + EK E+ +K+ P
Sbjct: 280 ITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLT 339
Query: 235 KANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGG 294
K N + P S Y G P N S S D G
Sbjct: 340 KINSVKLNSLP-----SEYESGSACPAQTVHYRPIN----LSSSENKIVNVSLADLRGGN 390
Query: 295 HRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPY 354
+ P T D++ QR +SM QL+QW+ +++G E+ R + + R +P +
Sbjct: 391 RPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQI 450
Query: 355 SSQYPDDYQYYPPG--VRPESICSM--PAYDRISPPWALEDKRHAFRNGGGPAYQLREWK 410
++YP+ Y+ P RPESICS+ +D+ P A E+KR + R+ +QL EW+
Sbjct: 451 MARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGA-EEKRRSMRD--DTMWQLYEWQ 507
Query: 411 EPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRS-HSVPRSPSQGSYSRAR 469
+ Y +Q +P S SS +++ ++ HS+P SPS GS + +
Sbjct: 508 QRQFYNKQST---LPRHS----------TLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQ 554
Query: 470 IYSP-------VRSPSARFERLPPRSEDIYADPAAYVM-RRSISS----PKVPPY----- 512
YSP V SP R + R + YV RRS+ + V P
Sbjct: 555 GYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGK 614
Query: 513 ---PEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTH 569
+ R +L+ Y+ E D D L +LCEQ+KVV + +QQL EK +LE AL+
Sbjct: 615 TLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSAS 674
Query: 570 QELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHD 629
QE+EM PA + + ++D LQN L++ ELS+AT L + EY+ LE +V+ +
Sbjct: 675 QEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRN 734
Query: 630 DLWEQLN----LDTQNEVLNR-QIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSA 684
+ EQL+ + T++ + R QIQKE+WRIQDVMEGL K+ RGT G
Sbjct: 735 QMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGS----- 789
Query: 685 TYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEPKANYEQSKKDPHQTLPLDT 744
PFS V P +Y K +P T +
Sbjct: 790 --------------------KPFSTVKYKNEGP----------DYRLYKSEPELTTVAEV 819
Query: 745 PRDISLVPTRQEVEAEKQAALNK-----VGVVPPRTKSPTDDEVTPSAVVRRNASGLTNG 799
D S + E +E + ++ K VGVVPPR KSPT + T ++ V +
Sbjct: 820 --DESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMD 877
Query: 800 LSSQERPKSAV----FPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQL----PASPAP 851
L + ERP+SAV + +M+VEEQ++R+RRHQ +REK++ L + SP
Sbjct: 878 LRT-ERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQ 936
Query: 852 DPS---PRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARLRKMELEPQ 908
PS P R R E+D + E ++ + +ETP EI +L+ E EPQ
Sbjct: 937 SPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPD------HETPATEIVQLK--ETEPQ 988
Query: 909 HYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVP 968
+VD +KEL + + E + EP+ ++ E+ +K++ +++ + S
Sbjct: 989 --NVDFSKELKKTENISY-EMLFEPEPN-GVNSVEMMDKERNKDKMPEDVTFSPQDETQT 1044
Query: 969 IGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPP 1028
+++++ + EQE+ + IS E SR + ++V+ +PSP +S ASP P
Sbjct: 1045 ANHKPEEHPEENTKNSVDEQEETV-ISYESTPEVSRGNQTMAVKSLSPSPESS-ASPVPS 1102
Query: 1029 ANPLSSE 1035
P +E
Sbjct: 1103 TQPQLTE 1109
>gi|219689123 pleckstrin homology domain containing, family A member 5
isoform 2 [Homo sapiens]
Length = 1105
Score = 421 bits (1083), Expect = e-117
Identities = 355/1151 (30%), Positives = 543/1151 (47%), Gaps = 169/1151 (14%)
Query: 1 MSNKTGGKRPATTNSDIPNHNMVSE--VPPERPSVRATRTARKAVAFGKRSHSMKRNPNA 58
M+++ +RP + ++ N+N+ S+ V P P R +R ++K FGKRS+S+KRNPNA
Sbjct: 1 MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA 60
Query: 59 PVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSD 118
PV + GWL+KQ S+G+K W KRWFVL D CLFYY+DEKEE ILGSI L SF++A + D
Sbjct: 61 PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED 120
Query: 119 NISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEK 178
+I+RK+ FKA H +RTY+F ++ +E E W++AM +AA VQ P ++ +K
Sbjct: 121 HINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRV---------DK 171
Query: 179 PDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKE----PPV 234
SEN P + + P H L KPE + + + + EK E+ +K+ P
Sbjct: 172 ITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLT 231
Query: 235 KANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGG 294
K N + P S Y G P N S S D G
Sbjct: 232 KINSVKLNSLP-----SEYESGSACPAQTVHYRPIN----LSSSENKIVNVSLADLRGGN 282
Query: 295 HRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPY 354
+ P T D++ QR +SM QL+QW+ +++G E+ R + + R +P +
Sbjct: 283 RPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQI 342
Query: 355 SSQYPDDYQYYPPG--VRPESICSM--PAYDRISPPWALEDKRHAFRNGGGPAYQLREWK 410
++YP+ Y+ P RPESICS+ +D+ P A E+KR + R+ +QL EW+
Sbjct: 343 MARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGA-EEKRRSMRD--DTMWQLYEWQ 399
Query: 411 EPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRS-HSVPRSPSQGSYSRAR 469
+ Y +Q +P S SS +++ ++ HS+P SPS GS + +
Sbjct: 400 QRQFYNKQST---LPRHS----------TLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQ 446
Query: 470 IYSP-------VRSPSARFERLPPRSEDIYADPAAYVM-RRSISS----PKVPPY----- 512
YSP V SP R + R + YV RRS+ + V P
Sbjct: 447 GYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGK 506
Query: 513 ----------------------PEVFRDSL--------------------HTYKLNEQDT 530
P++++ L + Y+ E D
Sbjct: 507 TMKENEPIITMVHTMIENSALRPQLYQQFLRQKSKISLYCLSQDEGRGTLYKYRPEEVDI 566
Query: 531 DKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLRHKKD 590
D L +LCEQ+KVV + +QQL EK +LE AL+ QE+EM PA + + ++D
Sbjct: 567 DAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRD 626
Query: 591 SLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHDDLWEQLN----LDTQNEVLNR 646
LQN L++ ELS+AT L + EY+ LE +V+ + + EQL+ + T++ + R
Sbjct: 627 DLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQR 686
Query: 647 -QIQKEIWRIQDVMEGLRKNNPSRGT------DTAKH----------RGGLGPSATYSSN 689
QIQKE+WRIQDVMEGL K+ RG T K+ R L S ++
Sbjct: 687 AQIQKELWRIQDVMEGLSKHKQQRGMIGSKPFSTVKYKNEEEEVVPPRPPLPRSYDFTEQ 746
Query: 690 SPASPL----SSASLTSPLSPFSLVSGS-----QGSPTKPGSNEPKANYEQSKKDPHQTL 740
P P SS+ L P L QG P P +Y K +P T
Sbjct: 747 PPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGYPRNGSHCGP--DYRLYKSEPELTT 804
Query: 741 PLDTPRDISLVPTRQEVEAEKQAALNK-----VGVVPPRTKSPTDDEVTPSAVVRRNASG 795
+ D S + E +E + ++ K VGVVPPR KSPT + T ++ V +
Sbjct: 805 VAEV--DESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTK 862
Query: 796 LTNGLSSQERPKSAV----FPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQL----PA 847
L + ERP+SAV + +M+VEEQ++R+RRHQ +REK++ L +
Sbjct: 863 KMMDLRT-ERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQ 921
Query: 848 SPAPDPS---PRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARLRKME 904
SP PS P R R E+D + E ++ + +ETP EI +L+ E
Sbjct: 922 SPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPD------HETPATEIVQLK--E 973
Query: 905 LEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQ 964
EPQ +VD +KEL + + E + EP+ ++ E+ +K++ +++ + S
Sbjct: 974 TEPQ--NVDFSKELKKTENISY-EMLFEPEPN-GVNSVEMMDKERNKDKMPEDVTFSPQD 1029
Query: 965 NVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPAS 1024
+++++ + EQE+ + IS E SR + ++V+ +PSP +S AS
Sbjct: 1030 ETQTANHKPEEHPEENTKNSVDEQEETV-ISYESTPEVSRGNQTMAVKSLSPSPESS-AS 1087
Query: 1025 PAPPANPLSSE 1035
P P P +E
Sbjct: 1088 PVPSTQPQLTE 1098
>gi|239047795 pleckstrin homology domain containing, family A member 7
[Homo sapiens]
Length = 1121
Score = 325 bits (833), Expect = 1e-88
Identities = 292/1034 (28%), Positives = 451/1034 (43%), Gaps = 236/1034 (22%)
Query: 1 MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPV 60
MS + +RP++ S+ S + +P + +++ K +FGKR +++RNPN PV
Sbjct: 107 MSKQDRNQRPSSMVSETSTAGTASTLEA-KPGPKIIKSSSKVHSFGKRDQAIRRNPNVPV 165
Query: 61 TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI 120
GWL KQ SSG++ W +RWFVL D CLFYYKD +EE++LGSIPL S+ ++ V P D I
Sbjct: 166 VVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRI 225
Query: 121 SRKHTFKAEH-------------------AGVRTYFFSAESPEEQEAWIQAMGEAARVQI 161
SRK++FKA H +G+RTY+FSA++ E+ AW++AM +AA+V
Sbjct: 226 SRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQV-- 283
Query: 162 PPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSL--PKPEPEAKTRGEGDGRGCEKA 219
+++ EK + + VP + H + P + RG D E+
Sbjct: 284 -----LSRSSLKRDMEKVERQAVPQANHTESCHECGRVGPGHTRDCPHRGHDDIVNFERQ 338
Query: 220 ERRPERPEVKKEPPVKANGLPAGPEPASEPGSPY------------PEGPRVPGGGEQPA 267
E+ E+ +++P G S+ SPY P GPR Q A
Sbjct: 339 EQEGEQYRSQRDP-------LEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRA 391
Query: 268 QPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRG 327
+ NG P+ G P + TGG++R+FPPRTNP+K +QRKS++ Q++ W ++G
Sbjct: 392 EKNGM---LPASYG----PGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWARAQKG 444
Query: 328 VPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMP--------- 378
SR P+ + +P S +P++YQ P R S S P
Sbjct: 445 ---------DSRSLPLDQTLPRQGPGQSLSFPENYQTLPKSTRHPSGGSSPPPRNLPSDY 495
Query: 379 --AYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDE 436
A DR S ++R A R+ G +QL EW++ + T P P + D+
Sbjct: 496 KYAQDRASHLKMSSEERRAHRD--GTVWQLYEWQQRQQFRHGSPTA--PICLGSPEFTDQ 551
Query: 437 LDAASSSLRRLSLQPRSHSVPRSPSQ-GSYSRARIYSPVR--SPSARFERLPP---RSED 490
R + PRS SVP SPS R++ P R +P+ R PP RS D
Sbjct: 552 -----GRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRRPHTPAERVTVKPPDQRRSVD 606
Query: 491 I------------------YAD----PAAYVMRRSISSPKV------PPYPEVFRD---- 518
I + D P+ M ++S+P + Y ++ +D
Sbjct: 607 ISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYL 666
Query: 519 -------------SLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESAL 565
SL K+ E DTD L CEQ++V+++ + ++ L+ K+ LES L
Sbjct: 667 DLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKENKDQLESVL 726
Query: 566 MGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVS 625
H+++E + QP + EK+ +++ LQ L++IR ELS+ +T + N+ EY LE++V
Sbjct: 727 EVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLKLENDVE 786
Query: 626 ALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKN------------NPSRGTDT 673
L L EQ + QIQK++WRI+DV GL N NP R T
Sbjct: 787 QLKQTLQEQHRRAFFFQE-KSQIQKDLWRIEDVTAGLSANKENFRILVESVKNPERKTVP 845
Query: 674 AKHRGGLGPSATYSSNSPASPLSSAS-LTSPLS------------------PFSLVSGSQ 714
+ +T S P P S + +PL V+
Sbjct: 846 LFPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPL 905
Query: 715 GSPTKPGSNEPKANYEQSKKDPHQTL--PLDTPRDISLVP--------------TRQEVE 758
SPTK +PK E + P L P D P + +P RQ E
Sbjct: 906 QSPTKA---KPKVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDE 962
Query: 759 AEKQAALNK------------------------------VGVVPPRTKSPT--------- 779
++ L + +G+V P ++ T
Sbjct: 963 RKRDRELGQCVNGDSRVELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLSGS 1022
Query: 780 ------DDEVTPSAVVRRNASGLTNGLSSQERPKSA---VFPGE-GKVKMSVEEQIDRMR 829
+ P +RR + + ++ RPKSA ++ G+ + KMS EEQ++RM+
Sbjct: 1023 TSRLQQSSTIAPYVTLRRGLNA-ESSKATFPRPKSALERLYSGDHQRGKMSAEEQLERMK 1081
Query: 830 RHQSGSMREKRRSL 843
RHQ +RE++R+L
Sbjct: 1082 RHQKALVRERKRTL 1095
>gi|238859653 pleckstrin homology domain containing family A member
4 isoform 2 [Homo sapiens]
Length = 583
Score = 147 bits (370), Expect = 7e-35
Identities = 113/380 (29%), Positives = 163/380 (42%), Gaps = 64/380 (16%)
Query: 7 GKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPVTKAGWL 66
G RP ++ S + + +S + P + TR K AFGKR ++++R+PN PV GWL
Sbjct: 3 GSRPRSSLSLASSASTISSLSSLSPK-KPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWL 61
Query: 67 FKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTF 126
KQ SSG++ W +RWFVL CLFYYKD +EES+LGS+ L S+ + P R+ TF
Sbjct: 62 HKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTF 121
Query: 127 KAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPDSENVPP 186
AEH G+RTY +A++ E+ W++A+G A+R + + A E P PP
Sbjct: 122 TAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGPP 181
Query: 187 SKHHQQPPHNSLPKPEPEAKTRGEG--------------DGRGCEKAE------------ 220
+ S PE +RG G G +A
Sbjct: 182 EVSRGEEGRIS-ESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP 240
Query: 221 -------------RRPERPEVKKEPPVKAN----------GLPAGP--EPASEPGSPYPE 255
RRP P PP + + L GP + S P +P
Sbjct: 241 SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG 300
Query: 256 GPRVPGGGEQPAQPNGWQYHSPSRPG----STAFPSQDGET-----GGHRRSFPPRTNPD 306
P GGG+ P P W ++PG ST S + +T G R R +
Sbjct: 301 PPSEAGGGKPPRSPQHWSQEPRTQPGPPLESTFHQSLETDTLLTKLCGQDRLL--RRLQE 358
Query: 307 KIAQRKSSMNQLQQWVNLRR 326
+I Q++ QL+ + L R
Sbjct: 359 EIDQKQEEKEQLEAALELTR 378
Score = 72.4 bits (176), Expect = 2e-12
Identities = 73/295 (24%), Positives = 119/295 (40%), Gaps = 33/295 (11%)
Query: 450 QPRSHSVPRSPSQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPKV 509
Q ++ S P +P +G S A P RSP + PR++
Sbjct: 287 QRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQE--PRTQP------------------G 326
Query: 510 PPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTH 569
PP F SL +TD LL KLC Q++++R + Q + EKE LE+AL T
Sbjct: 327 PPLESTFHQSL--------ETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTR 378
Query: 570 QELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHD 629
Q+L + P + ++ LQ++L+++R L T Y LE E+ L +
Sbjct: 379 QQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRE 438
Query: 630 DLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGL-RKNNPSRGTDTAKHRGGLGPSATYSS 688
L L+L + + ++ Q+++W ++D + GL P T+ L +
Sbjct: 439 TLEYLLHLGSPQDRVS--AQQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSER 496
Query: 689 NSPASPLSSASLTSPLSPFSLVSGSQGSPTKP--GSNEPKANYEQSKKDPHQTLP 741
S L +S SP + + G P G P+ + S + H P
Sbjct: 497 ESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSP 551
>gi|238859651 pleckstrin homology domain containing family A member
4 isoform 1 [Homo sapiens]
Length = 779
Score = 143 bits (361), Expect = 7e-34
Identities = 103/317 (32%), Positives = 145/317 (45%), Gaps = 26/317 (8%)
Query: 7 GKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPVTKAGWL 66
G RP ++ S + + +S + P + TR K AFGKR ++++R+PN PV GWL
Sbjct: 3 GSRPRSSLSLASSASTISSLSSLSPK-KPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWL 61
Query: 67 FKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTF 126
KQ SSG++ W +RWFVL CLFYYKD +EES+LGS+ L S+ + P R+ TF
Sbjct: 62 HKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTF 121
Query: 127 KAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPDSENVPP 186
AEH G+RTY +A++ E+ W++A+G A+R + + A E P PP
Sbjct: 122 TAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGPP 181
Query: 187 SKHHQQPPHNSLPKPEPEAKTRGEGDGR------------GCE-KAERRPERPEVKKEPP 233
+ S PE +RG G R G + + R P+ PP
Sbjct: 182 EVSRGEEGRIS-ESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP 240
Query: 234 -----VKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGW--QYHSPSRPGSTAFP 286
+ PA PA + P P P P W Q + SRP T
Sbjct: 241 SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRP-PTPRR 299
Query: 287 SQDGETGGHRRSFPPRT 303
E GG + PPR+
Sbjct: 300 GPPSEAGGGK---PPRS 313
Score = 80.1 bits (196), Expect = 1e-14
Identities = 86/347 (24%), Positives = 138/347 (39%), Gaps = 37/347 (10%)
Query: 450 QPRSHSVPRSPSQGSYSRARIYSPVRSP--------------SARFERLPPRSEDIYADP 495
Q ++ S P +P +G S A P RSP S + +LPPR
Sbjct: 287 QRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGT---- 342
Query: 496 AAYVMRRSISSPKVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLR 555
R S+ PP F SL +TD LL KLC Q++++R + Q +
Sbjct: 343 -----RASMVLLPGPPLESTFHQSL--------ETDTLLTKLCGQDRLLRRLQEEIDQKQ 389
Query: 556 AEKESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTI 615
EKE LE+AL T Q+L + P + ++ LQ++L+++R L T
Sbjct: 390 EEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQERERVWD 449
Query: 616 EYEHLESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGL-RKNNPSRGTDTA 674
Y LE E+ L + L L+L + + ++ Q+++W ++D + GL P T+
Sbjct: 450 TYSGLEQELGTLRETLEYLLHLGSPQDRVS--AQQQLWMVEDTLAGLGGPQKPPPHTEPD 507
Query: 675 KHRGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKP--GSNEPKANYEQS 732
L + S L +S SP + + G P G P+ + S
Sbjct: 508 SPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLGSPRVSRASS 567
Query: 733 KKDPHQTLP-LDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTKSP 778
+ H P L T ++ + + E+ + G PR SP
Sbjct: 568 PEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSP 614
Score = 34.7 bits (78), Expect = 0.48
Identities = 60/249 (24%), Positives = 94/249 (37%), Gaps = 32/249 (12%)
Query: 799 GLSSQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPSPRPA 858
GL ++P P + EE +R +S L P SP D P
Sbjct: 493 GLGGPQKPPPHTEPDSPSPVLQGEESSERESLPES-------LELSSPRSPETDWGRPPG 545
Query: 859 --YKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETP----REEIARLRKMELEPQHYDV 912
+ H + +S RA P G +P + +AR R M + Q +
Sbjct: 546 GDKDLASPHLGLGSPRVS------RASSPEGRHLPSPQLGTKAPVARPR-MSAQEQLERM 598
Query: 913 DINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEG 972
N+E P R + L LSP +Q VE+ + ++ S Q +
Sbjct: 599 RRNQECGRPFPRPTSPRLLTL--GRTLSPAR---RQPDVEQ-RPVVGHSGAQKW--LRSS 650
Query: 973 DSVDVPQDSESQLQ----EQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPP 1028
S P+++ L +E+ + +S ALATEAS+ RM++ P P PP
Sbjct: 651 GSWSSPRNTTPYLPTSEGHRERVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPP 710
Query: 1029 ANPLSSESP 1037
++P E+P
Sbjct: 711 SDPTRQETP 719
>gi|239755547 PREDICTED: similar to hCG2040524 [Homo sapiens]
Length = 209
Score = 112 bits (281), Expect = 1e-24
Identities = 62/157 (39%), Positives = 97/157 (61%), Gaps = 1/157 (0%)
Query: 870 EVDISNLEAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPER 929
+ D+ LE ++ E+ + + + +++LEPQ YD+DI++ELS P+KV IPER
Sbjct: 31 DFDLQLLERVVQGEKKDKEENGWLKVQAMPVTELDLEPQDYDLDISRELSKPEKVSIPER 90
Query: 930 YIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQE 989
Y++L+P+ P S EEL+ + +K E+I+ ++A+SSM N+ P D V D + QLQEQE
Sbjct: 91 YVELDPEEPPSLEELQARYRKAEKIRNILARSSMCNLQPTSGQDQNSV-ADLDLQLQEQE 149
Query: 990 KRIEISCALATEASRRGRMLSVQCATPSPPTSPASPA 1026
+ I IS ALA+EAS+R + ++V P PA
Sbjct: 150 RIINISYALASEASQRSKQVAVGHPDAREPVQTTLPA 186
>gi|239749985 PREDICTED: hypothetical protein XP_002347262 [Homo
sapiens]
Length = 209
Score = 112 bits (281), Expect = 1e-24
Identities = 62/157 (39%), Positives = 97/157 (61%), Gaps = 1/157 (0%)
Query: 870 EVDISNLEAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPER 929
+ D+ LE ++ E+ + + + +++LEPQ YD+DI++ELS P+KV IPER
Sbjct: 31 DFDLQLLERVVQGEKKDKEENGWLKVQAMPVTELDLEPQDYDLDISRELSKPEKVSIPER 90
Query: 930 YIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQE 989
Y++L+P+ P S EEL+ + +K E+I+ ++A+SSM N+ P D V D + QLQEQE
Sbjct: 91 YVELDPEEPPSLEELQARYRKAEKIRNILARSSMCNLQPTSGQDQNSV-ADLDLQLQEQE 149
Query: 990 KRIEISCALATEASRRGRMLSVQCATPSPPTSPASPA 1026
+ I IS ALA+EAS+R + ++V P PA
Sbjct: 150 RIINISYALASEASQRSKQVAVGHPDAREPVQTTLPA 186
>gi|239744296 PREDICTED: hypothetical protein XP_002343091 [Homo
sapiens]
Length = 209
Score = 112 bits (281), Expect = 1e-24
Identities = 62/157 (39%), Positives = 97/157 (61%), Gaps = 1/157 (0%)
Query: 870 EVDISNLEAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPER 929
+ D+ LE ++ E+ + + + +++LEPQ YD+DI++ELS P+KV IPER
Sbjct: 31 DFDLQLLERVVQGEKKDKEENGWLKVQAMPVTELDLEPQDYDLDISRELSKPEKVSIPER 90
Query: 930 YIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQE 989
Y++L+P+ P S EEL+ + +K E+I+ ++A+SSM N+ P D V D + QLQEQE
Sbjct: 91 YVELDPEEPPSLEELQARYRKAEKIRNILARSSMCNLQPTSGQDQNSV-ADLDLQLQEQE 149
Query: 990 KRIEISCALATEASRRGRMLSVQCATPSPPTSPASPA 1026
+ I IS ALA+EAS+R + ++V P PA
Sbjct: 150 RIINISYALASEASQRSKQVAVGHPDAREPVQTTLPA 186
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 73.6 bits (179), Expect = 9e-13
Identities = 50/138 (36%), Positives = 64/138 (46%), Gaps = 16/138 (11%)
Query: 31 PSVRATRTAR-KAVAFGKRSHSMKRNPN----APVTKAGWLFKQASSGVKQWNKRWFVLV 85
P +R R AR K++ G++S S R P PV KAGWL KQ S +K W +RWFVL
Sbjct: 4 PKIRQARRARSKSLVMGEQSRSPGRMPCPHRLGPVLKAGWLKKQRSI-MKNWQQRWFVLR 62
Query: 86 DRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGV----------RT 135
LFYYKD+ E G I L +V + P KH F+ G
Sbjct: 63 GDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPGKHLFEISPGGAGEREKVPANPEA 122
Query: 136 YFFSAESPEEQEAWIQAM 153
A S + E W+QA+
Sbjct: 123 LLLMASSQRDMEDWVQAI 140
>gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Homo
sapiens]
Length = 1034
Score = 69.7 bits (169), Expect = 1e-11
Identities = 43/155 (27%), Positives = 76/155 (49%), Gaps = 15/155 (9%)
Query: 64 GWLFKQASSGV---KQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI 120
GWL+K+ + ++W K WFVL D L++Y +E++E G I L F+ + +
Sbjct: 575 GWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFK---IDRASEC 631
Query: 121 SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAM-----GEAARVQIPPAQKSVPQAVRHS 175
+K+ FKA H +++++F+AE ++ W+ + G A R +I Q ++ +
Sbjct: 632 RKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEE 691
Query: 176 HEKPDSEN----VPPSKHHQQPPHNSLPKPEPEAK 206
+ P + PP + +PP S P EAK
Sbjct: 692 ADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAK 726
>gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 67.0 bits (162), Expect = 9e-11
Identities = 34/132 (25%), Positives = 59/132 (44%), Gaps = 6/132 (4%)
Query: 64 GWLFKQASSGV---KQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI 120
GWL+K+ G +W K W +L L++Y ++ E G + L F V+ +
Sbjct: 47 GWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDF---TVERASEC 103
Query: 121 SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD 180
+KH FK H ++T++F+AE+ +E W+ +G A Q + + +
Sbjct: 104 KKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEI 163
Query: 181 SENVPPSKHHQQ 192
+ PP H Q
Sbjct: 164 AAETPPPPHASQ 175
>gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 67.0 bits (162), Expect = 9e-11
Identities = 34/132 (25%), Positives = 59/132 (44%), Gaps = 6/132 (4%)
Query: 64 GWLFKQASSGV---KQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI 120
GWL+K+ G +W K W +L L++Y ++ E G + L F V+ +
Sbjct: 47 GWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDF---TVERASEC 103
Query: 121 SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD 180
+KH FK H ++T++F+AE+ +E W+ +G A Q + + +
Sbjct: 104 KKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEI 163
Query: 181 SENVPPSKHHQQ 192
+ PP H Q
Sbjct: 164 AAETPPPPHASQ 175
>gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo
sapiens]
Length = 437
Score = 67.0 bits (162), Expect = 9e-11
Identities = 34/132 (25%), Positives = 59/132 (44%), Gaps = 6/132 (4%)
Query: 64 GWLFKQASSGV---KQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI 120
GWL+K+ G +W K W +L L++Y ++ E G + L F V+ +
Sbjct: 46 GWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDF---TVERASEC 102
Query: 121 SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD 180
+KH FK H ++T++F+AE+ +E W+ +G A Q + + +
Sbjct: 103 KKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEI 162
Query: 181 SENVPPSKHHQQ 192
+ PP H Q
Sbjct: 163 AAETPPPPHASQ 174
>gi|24432056 hypothetical protein LOC144717 [Homo sapiens]
Length = 249
Score = 66.2 bits (160), Expect = 1e-10
Identities = 62/218 (28%), Positives = 92/218 (42%), Gaps = 25/218 (11%)
Query: 47 KRSHSMKRNPNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPL 106
+RS + +APV AG+L+K+ +++RWFVL LFY++D +G I L
Sbjct: 5 ERSLAFYATCDAPVDNAGFLYKKGGRHAA-YHRRWFVLRGNMLFYFEDAASREPVGVIIL 63
Query: 107 LSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQK 166
V V+ ++ + F A RTY +AES + E W++A+ A+ + +
Sbjct: 64 EGCTVELVEAAEEFAFAVRFAGTRA--RTYVLAAESQDAMEGWVKALSRASFDYLRLVVR 121
Query: 167 SVPQ---AVRHS------HEKPDSENVPPSKHHQQPPHNSLPK--------PEPEAKTRG 209
+ Q AVR +P S +PPS P SLP P P +
Sbjct: 122 ELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSAL 181
Query: 210 EGDGRGC----EKAERRPERPEVKKEPPVKANGLPAGP 243
GC +A RP PE PP + P GP
Sbjct: 182 PPKENGCAVWSTEATFRP-GPEPPPPPPRRRASAPHGP 218
>gi|50980301 myosin phosphatase-Rho interacting protein isoform 2
[Homo sapiens]
Length = 1025
Score = 63.2 bits (152), Expect = 1e-09
Identities = 69/248 (27%), Positives = 102/248 (41%), Gaps = 29/248 (11%)
Query: 21 NMVSEVPPER-PSVRATRTA--RKAVAFGKRSHSMKRNPNAPVTKAGWLFKQASSGVKQW 77
+ +E PP P A+ + R+A + +RS P+ K GWL KQ G QW
Sbjct: 346 DFTNEAPPAPLPDASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDG--QW 403
Query: 78 NKRWFVLVDRCLFYYKD---EKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVR 134
K WFVL D+ L YY+D E+ + G I L + P + R + F+ H
Sbjct: 404 KKHWFVLADQSLRYYRDSVAEEAADLDGEIDLSACYDVTEYP---VQRNYGFQI-HTKEG 459
Query: 135 TYFFSAESPEEQEAWIQA-MGEAARVQIPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQP 193
+ SA + + WIQ M P S+P+ S ++ P K +
Sbjct: 460 EFTLSAMTSGIRRNWIQTIMKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAE- 518
Query: 194 PHNSLPKPEPEAK------TRGEGDGRGCEKAERRPERPEVKKEPPVKANGLPAGPEPAS 247
L +P+PE K R EG + + AE RP + + +E + G+ GP
Sbjct: 519 ----LGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQE---RVGGV--GPADTH 569
Query: 248 EPGSPYPE 255
EP P E
Sbjct: 570 EPLRPEAE 577
Score = 39.7 bits (91), Expect = 0.015
Identities = 35/134 (26%), Positives = 62/134 (46%), Gaps = 11/134 (8%)
Query: 539 EQNKVVREQDRLVQQLRAEKESLESALMGTHQ---ELEMFGSQPAYPEKLRHKKDSLQNQ 595
E K+ E+DRL+ + A S A+ H+ E E+ SQ + + ++L+ Q
Sbjct: 749 ELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQ 808
Query: 596 ----LINIRVELSQATTALTNSTIEYEH----LESEVSALHDDLWEQLNLDTQNEVLNRQ 647
L +++ EL + + +E H LE+E AL E L+ N+ LN +
Sbjct: 809 YLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNR 868
Query: 648 IQKEIWRIQDVMEG 661
+ EI R++ ++ G
Sbjct: 869 LAAEITRLRTLLTG 882
>gi|50980307 myosin phosphatase-Rho interacting protein isoform 1
[Homo sapiens]
Length = 1038
Score = 63.2 bits (152), Expect = 1e-09
Identities = 69/248 (27%), Positives = 102/248 (41%), Gaps = 29/248 (11%)
Query: 21 NMVSEVPPER-PSVRATRTA--RKAVAFGKRSHSMKRNPNAPVTKAGWLFKQASSGVKQW 77
+ +E PP P A+ + R+A + +RS P+ K GWL KQ G QW
Sbjct: 346 DFTNEAPPAPLPDASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDG--QW 403
Query: 78 NKRWFVLVDRCLFYYKD---EKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVR 134
K WFVL D+ L YY+D E+ + G I L + P + R + F+ H
Sbjct: 404 KKHWFVLADQSLRYYRDSVAEEAADLDGEIDLSACYDVTEYP---VQRNYGFQI-HTKEG 459
Query: 135 TYFFSAESPEEQEAWIQA-MGEAARVQIPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQP 193
+ SA + + WIQ M P S+P+ S ++ P K +
Sbjct: 460 EFTLSAMTSGIRRNWIQTIMKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAE- 518
Query: 194 PHNSLPKPEPEAK------TRGEGDGRGCEKAERRPERPEVKKEPPVKANGLPAGPEPAS 247
L +P+PE K R EG + + AE RP + + +E + G+ GP
Sbjct: 519 ----LGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQE---RVGGV--GPADTH 569
Query: 248 EPGSPYPE 255
EP P E
Sbjct: 570 EPLRPEAE 577
Score = 39.7 bits (91), Expect = 0.015
Identities = 35/134 (26%), Positives = 62/134 (46%), Gaps = 11/134 (8%)
Query: 539 EQNKVVREQDRLVQQLRAEKESLESALMGTHQ---ELEMFGSQPAYPEKLRHKKDSLQNQ 595
E K+ E+DRL+ + A S A+ H+ E E+ SQ + + ++L+ Q
Sbjct: 749 ELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQ 808
Query: 596 ----LINIRVELSQATTALTNSTIEYEH----LESEVSALHDDLWEQLNLDTQNEVLNRQ 647
L +++ EL + + +E H LE+E AL E L+ N+ LN +
Sbjct: 809 YLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNR 868
Query: 648 IQKEIWRIQDVMEG 661
+ EI R++ ++ G
Sbjct: 869 LAAEITRLRTLLTG 882
>gi|50234893 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 60.5 bits (145), Expect = 8e-09
Identities = 48/151 (31%), Positives = 73/151 (48%), Gaps = 16/151 (10%)
Query: 48 RSHSMKRNPNAP----VTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGS 103
+SH P P V KAG+ KQ + +K W +R+F L + + Y+K E E+ L
Sbjct: 176 QSHLPYFTPKPPQDSAVIKAGYCVKQGAV-MKNWKRRYFQLDENTIGYFKSELEKEPLRV 234
Query: 104 IPLLSF-RVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIP 162
IPL +V + SD + R + F+ RT++ A+SPEE +WI+A+ A Q
Sbjct: 235 IPLKEVHKVQECKQSDIMMRDNLFEIVTTS-RTFYVQADSPEEMHSWIKAVSGAIVAQRG 293
Query: 163 PAQKSVPQAVRHSHEKPDSENVPPSKHHQQP 193
P + + S E P + SKH +P
Sbjct: 294 PGRSA-------SSEHPPGPS--ESKHAFRP 315
Score = 35.8 bits (81), Expect = 0.22
Identities = 24/115 (20%), Positives = 53/115 (46%), Gaps = 8/115 (6%)
Query: 64 GWLFKQASSGVKQWNKRWFVLVDR--CLFYYKDEKEESILGSIPLLSFRVAAVQPSDNIS 121
G+L + + ++ +R+F+L R +Y D + GS + + ++ + + +
Sbjct: 12 GFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDAT 71
Query: 122 RKHTFKAE-----HAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQA 171
+ KAE +AG+R YF A ++ W+ + +A ++ +P S P +
Sbjct: 72 KLRP-KAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNS 125
>gi|31377720 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 60.5 bits (145), Expect = 8e-09
Identities = 48/151 (31%), Positives = 73/151 (48%), Gaps = 16/151 (10%)
Query: 48 RSHSMKRNPNAP----VTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGS 103
+SH P P V KAG+ KQ + +K W +R+F L + + Y+K E E+ L
Sbjct: 176 QSHLPYFTPKPPQDSAVIKAGYCVKQGAV-MKNWKRRYFQLDENTIGYFKSELEKEPLRV 234
Query: 104 IPLLSF-RVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIP 162
IPL +V + SD + R + F+ RT++ A+SPEE +WI+A+ A Q
Sbjct: 235 IPLKEVHKVQECKQSDIMMRDNLFEIVTTS-RTFYVQADSPEEMHSWIKAVSGAIVAQRG 293
Query: 163 PAQKSVPQAVRHSHEKPDSENVPPSKHHQQP 193
P + + S E P + SKH +P
Sbjct: 294 PGRSA-------SSEHPPGPS--ESKHAFRP 315
Score = 35.8 bits (81), Expect = 0.22
Identities = 24/115 (20%), Positives = 53/115 (46%), Gaps = 8/115 (6%)
Query: 64 GWLFKQASSGVKQWNKRWFVLVDR--CLFYYKDEKEESILGSIPLLSFRVAAVQPSDNIS 121
G+L + + ++ +R+F+L R +Y D + GS + + ++ + + +
Sbjct: 12 GFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDAT 71
Query: 122 RKHTFKAE-----HAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQA 171
+ KAE +AG+R YF A ++ W+ + +A ++ +P S P +
Sbjct: 72 KLRP-KAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNS 125
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 60.1 bits (144), Expect = 1e-08
Identities = 28/80 (35%), Positives = 42/80 (52%), Gaps = 1/80 (1%)
Query: 77 WNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTY 136
W K W V + CLF+YK ++ L S+PLL + + S+NI + + FK H Y
Sbjct: 949 WQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKL-HFKSHVY 1007
Query: 137 FFSAESPEEQEAWIQAMGEA 156
+F AES E W++ + A
Sbjct: 1008 YFRAESEYTFERWMEVIRSA 1027
>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
Length = 398
Score = 60.1 bits (144), Expect = 1e-08
Identities = 34/113 (30%), Positives = 53/113 (46%), Gaps = 18/113 (15%)
Query: 62 KAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPS---- 117
+ GWL K VK W +RWF+L D CL+Y++ ++ G IPL + + V+ S
Sbjct: 263 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPN 322
Query: 118 ----------DNISRKHTFKAEHAGVR----TYFFSAESPEEQEAWIQAMGEA 156
D + + +A+ V Y SA +PEE+E WI+ + A
Sbjct: 323 CFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAA 375
>gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform d [Homo sapiens]
Length = 1133
Score = 59.7 bits (143), Expect = 1e-08
Identities = 35/112 (31%), Positives = 58/112 (51%), Gaps = 11/112 (9%)
Query: 60 VTKAGWLFKQASSGV--------KQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRV 111
V+ +G+L+K AS+G +++++RW VL D L Y+++E+ + G I
Sbjct: 438 VSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVC 497
Query: 112 AAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPP 163
AV P D +HTF+ G R Y F ES E+ W++ + A+ +PP
Sbjct: 498 LAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCI---AKAFVPP 546
Score = 43.9 bits (102), Expect = 8e-04
Identities = 36/113 (31%), Positives = 50/113 (44%), Gaps = 9/113 (7%)
Query: 56 PNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQ 115
P PV KAGWL K G + KRW L L Y+ K+ S R +V
Sbjct: 79 PVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD--------AYSKRFISVA 130
Query: 116 PSDNISRKHTFKAE-HAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKS 167
+++ K E RT+ F AES E++ W+QA+ +A Q A+ S
Sbjct: 131 CISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLS 183
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform a [Homo sapiens]
Length = 1205
Score = 59.7 bits (143), Expect = 1e-08
Identities = 35/112 (31%), Positives = 58/112 (51%), Gaps = 11/112 (9%)
Query: 60 VTKAGWLFKQASSGV--------KQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRV 111
V+ +G+L+K AS+G +++++RW VL D L Y+++E+ + G I
Sbjct: 499 VSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVC 558
Query: 112 AAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPP 163
AV P D +HTF+ G R Y F ES E+ W++ + A+ +PP
Sbjct: 559 LAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCI---AKAFVPP 607
Score = 43.9 bits (102), Expect = 8e-04
Identities = 36/113 (31%), Positives = 50/113 (44%), Gaps = 9/113 (7%)
Query: 56 PNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQ 115
P PV KAGWL K G + KRW L L Y+ K+ S R +V
Sbjct: 79 PVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD--------AYSKRFISVA 130
Query: 116 PSDNISRKHTFKAE-HAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKS 167
+++ K E RT+ F AES E++ W+QA+ +A Q A+ S
Sbjct: 131 CISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLS 183
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform c [Homo sapiens]
Length = 1450
Score = 59.7 bits (143), Expect = 1e-08
Identities = 35/112 (31%), Positives = 58/112 (51%), Gaps = 11/112 (9%)
Query: 60 VTKAGWLFKQASSGV--------KQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRV 111
V+ +G+L+K AS+G +++++RW VL D L Y+++E+ + G I
Sbjct: 744 VSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVC 803
Query: 112 AAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPP 163
AV P D +HTF+ G R Y F ES E+ W++ + A+ +PP
Sbjct: 804 LAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCI---AKAFVPP 852
Score = 43.9 bits (102), Expect = 8e-04
Identities = 36/113 (31%), Positives = 50/113 (44%), Gaps = 9/113 (7%)
Query: 56 PNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQ 115
P PV KAGWL K G + KRW L L Y+ K+ S R +V
Sbjct: 324 PVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD--------AYSKRFISVA 375
Query: 116 PSDNISRKHTFKAE-HAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKS 167
+++ K E RT+ F AES E++ W+QA+ +A Q A+ S
Sbjct: 376 CISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLS 428
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 59.7 bits (143), Expect = 1e-08
Identities = 28/81 (34%), Positives = 45/81 (55%), Gaps = 1/81 (1%)
Query: 77 WNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTY 136
W K W V + CLF+YK +++ L S+PLL + V+ + +D I + + FK + Y
Sbjct: 946 WQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKS-HVY 1004
Query: 137 FFSAESPEEQEAWIQAMGEAA 157
FF AES E W++ + A+
Sbjct: 1005 FFRAESKYTFERWMEVIQGAS 1025
>gi|217416392 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 2 [Homo sapiens]
Length = 1493
Score = 57.4 bits (137), Expect = 7e-08
Identities = 50/192 (26%), Positives = 77/192 (40%), Gaps = 23/192 (11%)
Query: 3 NKTGGKRPATTNSDIPNHNMVSE----VPPERPSVRATRTARKAVAFGKRSHSMKRNPNA 58
+++G P + ++ SE +PP+ S + + S S N
Sbjct: 643 SRSGPGSPRAMKRGVSLSSVASESDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGKNE 702
Query: 59 PVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKE--ESILGSIPLLSFRVAAVQP 116
P+ K+G+L K S VK W +RWFVL L YYK + G I L + ++
Sbjct: 703 PLEKSGYLLKM-SGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSA--SCSILR 759
Query: 117 SDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQI----------PPAQK 166
DN +H TY+ +A+SP E WI+ + RVQ P K
Sbjct: 760 GDNKQTVQLTTEKH----TYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQPEGKPTMK 815
Query: 167 SVPQAVRHSHEK 178
+ V+H + K
Sbjct: 816 GLLTKVKHGYSK 827
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 57.4 bits (137), Expect = 7e-08
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 18/122 (14%)
Query: 60 VTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDN 119
V G+LFK+AS+ K WN+RWF + + L Y K K+ ++ + R+ +V+P ++
Sbjct: 269 VVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDAL---TVVVDDLRLCSVKPCED 325
Query: 120 ISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKP 179
I R+ F+ + ++ A+S + ++AW+QA+ Q S+ A R E P
Sbjct: 326 IERRFCFEV-LSPTKSCMLQADSEKLRQAWVQAV-----------QASIASAYR---ESP 370
Query: 180 DS 181
DS
Sbjct: 371 DS 372
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 55.8 bits (133), Expect = 2e-07
Identities = 34/113 (30%), Positives = 53/113 (46%), Gaps = 19/113 (16%)
Query: 62 KAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPS---- 117
+ GWL K VK W +RWF+L D CL+Y++ ++ G IPL + + V+ S
Sbjct: 263 REGWLLKLGGR-VKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPN 321
Query: 118 ----------DNISRKHTFKAEHAGVR----TYFFSAESPEEQEAWIQAMGEA 156
D + + +A+ V Y SA +PEE+E WI+ + A
Sbjct: 322 CFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAA 374
>gi|4758968 cytohesin 3 [Homo sapiens]
Length = 399
Score = 55.1 bits (131), Expect = 3e-07
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 19/110 (17%)
Query: 62 KAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNIS 121
+ GWL K VK W +RWF+L D CL+Y++ ++ G IPL + + V+ +
Sbjct: 267 REGWLLKLGGR-VKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPN 325
Query: 122 RKHTFKAEHAGV------------------RTYFFSAESPEEQEAWIQAM 153
+ H G Y SA SPEE+E W++++
Sbjct: 326 CFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSI 375
>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
Length = 400
Score = 54.7 bits (130), Expect = 5e-07
Identities = 33/116 (28%), Positives = 51/116 (43%), Gaps = 18/116 (15%)
Query: 62 KAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQ------ 115
+ GWL K VK W +RWF+L D CL+Y++ ++ G IPL + + V
Sbjct: 262 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPN 321
Query: 116 ------PSDNISRKHTFKAEHAG------VRTYFFSAESPEEQEAWIQAMGEAARV 159
P++ K E G Y SA + EE++ WI+++ A V
Sbjct: 322 CFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSV 377
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,091,136
Number of Sequences: 37866
Number of extensions: 3051218
Number of successful extensions: 23640
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 152
Number of HSP's successfully gapped in prelim test: 1185
Number of HSP's that attempted gapping in prelim test: 16856
Number of HSP's gapped (non-prelim): 7108
length of query: 1048
length of database: 18,247,518
effective HSP length: 113
effective length of query: 935
effective length of database: 13,968,660
effective search space: 13060697100
effective search space used: 13060697100
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.