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Search of human proteins with 37595545
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
(523 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 1052 0.0
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 716 0.0
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 716 0.0
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 652 0.0
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 645 0.0
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 645 0.0
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens] 373 e-103
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens] 345 4e-95
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 338 7e-93
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 333 2e-91
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 331 9e-91
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 325 6e-89
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 316 4e-86
gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens] 249 4e-66
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 241 2e-63
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 241 2e-63
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 241 2e-63
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 241 2e-63
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 241 2e-63
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 241 2e-63
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 239 6e-63
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 239 6e-63
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 236 3e-62
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 221 1e-57
gi|11496279 male germ cell-associated kinase [Homo sapiens] 220 2e-57
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 217 2e-56
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 217 2e-56
gi|27477122 intestinal cell kinase [Homo sapiens] 214 2e-55
gi|7662388 intestinal cell kinase [Homo sapiens] 214 2e-55
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 214 2e-55
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 1052 bits (2720), Expect = 0.0
Identities = 523/523 (100%), Positives = 523/523 (100%)
Query: 1 MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60
MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ
Sbjct: 1 MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60
Query: 61 YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120
YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV
Sbjct: 61 YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120
Query: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180
QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS
Sbjct: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180
Query: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240
LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS
Sbjct: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240
Query: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG
Sbjct: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL
Sbjct: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE
Sbjct: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
Query: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI
Sbjct: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
Query: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF 523
HALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF
Sbjct: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF 523
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 716 bits (1849), Expect = 0.0
Identities = 356/512 (69%), Positives = 424/512 (82%), Gaps = 30/512 (5%)
Query: 1 MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60
MKK KR+LS+TLRG + ID++ + EQ+ ++E+ G P
Sbjct: 10 MKKIKRQLSMTLRGGRGIDKT-NGAPEQIGLDESGGG-------GGSDPG---------- 51
Query: 61 YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120
+ P R + + G + P +IVHE+LKMGSDGESDQAS TSSDEV
Sbjct: 52 ------EAPTRAAPGELRSARGPLSSAP------EIVHEDLKMGSDGESDQASATSSDEV 99
Query: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180
QSP V +RN R+IS ED+NKRLSLPADIR+P+GYLEKL +NSP FD+P+SRR RR S
Sbjct: 100 QSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVS 159
Query: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240
LSEIGFGK+ETYIKL+KLGEGTYATVYKG+SKLT+NLVALKEIRLEHEEGAPCTAIREVS
Sbjct: 160 LSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVS 219
Query: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
LLKDLKHANIVTLHDI+HT+KSLTLVFEYLDKDLKQY+DDCGNI++MHNVKLFL+Q+LRG
Sbjct: 220 LLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRG 279
Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
LAYCHR+KVLHRDLKPQNLLINE+GELKLADFGLARAKS+PTKTYSNEVVTLWYRPPD+L
Sbjct: 280 LAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDIL 339
Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
LGS++YSTQIDMWGVGCIF+EMA+GRPLFPGSTVE++LH IFR+LGTP++ETWPGI SNE
Sbjct: 340 LGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNE 399
Query: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
EFK YN+PKY+ + L++HAPRLDS+G +L+TK LQ+E + R+SAE+AMKH +F SLG RI
Sbjct: 400 EFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERI 459
Query: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETG 512
H LP++ SIF+LKEIQLQK+ R+SS P++G
Sbjct: 460 HKLPDTTSIFALKEIQLQKEASLRSSSMPDSG 491
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 716 bits (1849), Expect = 0.0
Identities = 356/512 (69%), Positives = 424/512 (82%), Gaps = 30/512 (5%)
Query: 1 MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60
MKK KR+LS+TLRG + ID++ + EQ+ ++E+ G P
Sbjct: 4 MKKIKRQLSMTLRGGRGIDKT-NGAPEQIGLDESGGG-------GGSDPG---------- 45
Query: 61 YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120
+ P R + + G + P +IVHE+LKMGSDGESDQAS TSSDEV
Sbjct: 46 ------EAPTRAAPGELRSARGPLSSAP------EIVHEDLKMGSDGESDQASATSSDEV 93
Query: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180
QSP V +RN R+IS ED+NKRLSLPADIR+P+GYLEKL +NSP FD+P+SRR RR S
Sbjct: 94 QSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVS 153
Query: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240
LSEIGFGK+ETYIKL+KLGEGTYATVYKG+SKLT+NLVALKEIRLEHEEGAPCTAIREVS
Sbjct: 154 LSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVS 213
Query: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
LLKDLKHANIVTLHDI+HT+KSLTLVFEYLDKDLKQY+DDCGNI++MHNVKLFL+Q+LRG
Sbjct: 214 LLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRG 273
Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
LAYCHR+KVLHRDLKPQNLLINE+GELKLADFGLARAKS+PTKTYSNEVVTLWYRPPD+L
Sbjct: 274 LAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDIL 333
Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
LGS++YSTQIDMWGVGCIF+EMA+GRPLFPGSTVE++LH IFR+LGTP++ETWPGI SNE
Sbjct: 334 LGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNE 393
Query: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
EFK YN+PKY+ + L++HAPRLDS+G +L+TK LQ+E + R+SAE+AMKH +F SLG RI
Sbjct: 394 EFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERI 453
Query: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETG 512
H LP++ SIF+LKEIQLQK+ R+SS P++G
Sbjct: 454 HKLPDTTSIFALKEIQLQKEASLRSSSMPDSG 485
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 652 bits (1681), Expect = 0.0
Identities = 335/526 (63%), Positives = 402/526 (76%), Gaps = 33/526 (6%)
Query: 1 MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGR-PPTSHSMHSFLH 59
MK FKRR SL++ ++TI+ESL+E EQ N +N + GR PP S S
Sbjct: 6 MKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECSTFS--- 62
Query: 60 QYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDE 119
T S ++P P G +N R + +ASG +
Sbjct: 63 -PTDSGEEPGQLSP--------GVQFQRRQNQRRFSM------------EVRASGALPRQ 101
Query: 120 VQSPTGVCLRNRIHRRISME----DLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRR 175
V C +HRR + D++KRLSLP DIR+P +L+KLQ+ SP +P+SR
Sbjct: 102 VAG----CTHKGVHRRAAALQPDFDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRM 157
Query: 176 SRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTA 235
SRRASLS+IGFGK+ETY+KL+KLGEGTYATV+KGRSKLTENLVALKEIRLEHEEGAPCTA
Sbjct: 158 SRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTA 217
Query: 236 IREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLY 295
IREVSLLK+LKHANIVTLHD++HTD+SLTLVFEYLD DLKQY+D CGN+MSMHNVK+F++
Sbjct: 218 IREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMF 277
Query: 296 QILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYR 355
Q+LRGLAYCH RK+LHRDLKPQNLLINE+GELKLADFGLARAKSVPTKTYSNEVVTLWYR
Sbjct: 278 QLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYR 337
Query: 356 PPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPG 415
PPDVLLGS+EYST IDMWGVGCI +EMA+GRPLFPGSTV++ELHLIFRLLGTP++ETWPG
Sbjct: 338 PPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPG 397
Query: 416 ISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRS 475
+++ EF+ Y+FP Y PQPLINHAPRLD++GI L++ L YESK R+SAE A+ H YFRS
Sbjct: 398 VTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRS 457
Query: 476 LGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSM 521
LG R+H L ++ SIFSLKEIQLQKDPG+R ++ + G GKNRRQS+
Sbjct: 458 LGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSI 503
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 645 bits (1665), Expect = 0.0
Identities = 331/521 (63%), Positives = 396/521 (76%), Gaps = 53/521 (10%)
Query: 1 MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60
MK FKRR SL++ ++TI+ESL+E
Sbjct: 6 MKNFKRRFSLSVPRTETIEESLAE------------------------------------ 29
Query: 61 YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120
+T F + RR ++ G LG P+ S S +S + G S V
Sbjct: 30 FTEQFNQLHNRRNENLQLGPLGR--DPPQECSTF----------SPTDSGEEPGQLSPGV 77
Query: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180
Q R + RR SMED++KRLSLP DIR+P +L+KLQ+ SP +P+SR SRRAS
Sbjct: 78 QFQ-----RRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRAS 132
Query: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240
LS+IGFGK+ETY+KL+KLGEGTYATV+KGRSKLTENLVALKEIRLEHEEGAPCTAIREVS
Sbjct: 133 LSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 192
Query: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
LLK+LKHANIVTLHD++HTD+SLTLVFEYLD DLKQY+D CGN+MSMHNVK+F++Q+LRG
Sbjct: 193 LLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRG 252
Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
LAYCH RK+LHRDLKPQNLLINE+GELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL
Sbjct: 253 LAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 312
Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
LGS+EYST IDMWGVGCI +EMA+GRPLFPGSTV++ELHLIFRLLGTP++ETWPG+++
Sbjct: 313 LGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFS 372
Query: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
EF+ Y+FP Y PQPLINHAPRLD++GI L++ L YESK R+SAE A+ H YFRSLG R+
Sbjct: 373 EFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERV 432
Query: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSM 521
H L ++ SIFSLKEIQLQKDPG+R ++ + G GKNRRQS+
Sbjct: 433 HQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSI 473
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 645 bits (1665), Expect = 0.0
Identities = 331/521 (63%), Positives = 396/521 (76%), Gaps = 53/521 (10%)
Query: 1 MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60
MK FKRR SL++ ++TI+ESL+E
Sbjct: 6 MKNFKRRFSLSVPRTETIEESLAE------------------------------------ 29
Query: 61 YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120
+T F + RR ++ G LG P+ S S +S + G S V
Sbjct: 30 FTEQFNQLHNRRNENLQLGPLGR--DPPQECSTF----------SPTDSGEEPGQLSPGV 77
Query: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180
Q R + RR SMED++KRLSLP DIR+P +L+KLQ+ SP +P+SR SRRAS
Sbjct: 78 QFQ-----RRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRAS 132
Query: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240
LS+IGFGK+ETY+KL+KLGEGTYATV+KGRSKLTENLVALKEIRLEHEEGAPCTAIREVS
Sbjct: 133 LSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 192
Query: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
LLK+LKHANIVTLHD++HTD+SLTLVFEYLD DLKQY+D CGN+MSMHNVK+F++Q+LRG
Sbjct: 193 LLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRG 252
Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
LAYCH RK+LHRDLKPQNLLINE+GELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL
Sbjct: 253 LAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 312
Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
LGS+EYST IDMWGVGCI +EMA+GRPLFPGSTV++ELHLIFRLLGTP++ETWPG+++
Sbjct: 313 LGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFS 372
Query: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
EF+ Y+FP Y PQPLINHAPRLD++GI L++ L YESK R+SAE A+ H YFRSLG R+
Sbjct: 373 EFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERV 432
Query: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSM 521
H L ++ SIFSLKEIQLQKDPG+R ++ + G GKNRRQS+
Sbjct: 433 HQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSI 473
>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
Length = 451
Score = 373 bits (957), Expect = e-103
Identities = 196/339 (57%), Positives = 241/339 (71%), Gaps = 17/339 (5%)
Query: 174 RRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPC 233
R S +S + FGK ++Y KLEKLGEG+YATVYKG+SK+ LVALK IRL+ EEG P
Sbjct: 99 RHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPF 158
Query: 234 TAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLF 293
TAIRE SLLK LKHANIV LHDI+HT ++LTLVFEY+ DL QYMD + NVKLF
Sbjct: 159 TAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLF 218
Query: 294 LYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLW 353
L+Q+LRGL+Y H+R +LHRDLKPQNLLI++ GELKLADFGLARAKSVP+ TYSNEVVTLW
Sbjct: 219 LFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLW 278
Query: 354 YRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPG-STVEDELHLIFRLLGTPSQET 412
YRPPDVLLGS+EYST +DMWGVGCIF EM G FPG ++D+L IF +LGTP+++T
Sbjct: 279 YRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDT 338
Query: 413 WPGISSNEEFKNYNFPKYKPQPL---------INHAPRLDSEGIELITKFLQYESKKRVS 463
WPG+ S FK F Y + L +NHA +L +K LQ K R+S
Sbjct: 339 WPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAE-------DLASKLLQCSPKNRLS 391
Query: 464 AEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPG 502
A+ A+ H YF L PR+ L + SIF++ ++LQ + G
Sbjct: 392 AQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAG 430
>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
Length = 384
Score = 345 bits (886), Expect = 4e-95
Identities = 176/331 (53%), Positives = 236/331 (71%), Gaps = 3/331 (0%)
Query: 186 FGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDL 245
FG +Y+ LEKLGEG+YATVYKG S++ LVALK I + EEG P TAIRE SLLK L
Sbjct: 46 FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105
Query: 246 KHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCH 305
KHANIV LHDI+HT ++LT VFEY+ DL QYM + HNV+LF++Q+LRGLAY H
Sbjct: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165
Query: 306 RRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSE 365
+ VLHRDLKPQNLLI+ GELKLADFGLARAKS+P++TYS+EVVTLWYRPPD LLG++E
Sbjct: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225
Query: 366 YSTQIDMWGVGCIFFEMASGRPLFPG-STVEDELHLIFRLLGTPSQETWPGISSNEEFKN 424
YS+++D+WG GCIF EM G+PLFPG S + ++L I+ +LG P+++TWPG+S +
Sbjct: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285
Query: 425 YNFPKYKPQPLINHAPRLD--SEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRIHA 482
FP P+ L RL E +L ++ L+ + RVSA+EA+ H YF +L +++
Sbjct: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345
Query: 483 LPESVSIFSLKEIQLQKDPGFRNSSYPETGH 513
LP+ S+F++ ++L+ + +SY + H
Sbjct: 346 LPDEESLFTVSGVRLKPEMCDLLASYQKGHH 376
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 338 bits (867), Expect = 7e-93
Identities = 165/293 (56%), Positives = 215/293 (73%), Gaps = 5/293 (1%)
Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 247
M+ Y KLEK+GEGTY TV+K +++ T +VALK +RL+ + EG P +A+RE+ LLK+LKH
Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
Query: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRR 307
NIV LHD++H+DK LTLVFE+ D+DLK+Y D C + VK FL+Q+L+GL +CH R
Sbjct: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120
Query: 308 KVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYS 367
VLHRDLKPQNLLIN GELKLADFGLARA +P + YS EVVTLWYRPPDVL G+ YS
Sbjct: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180
Query: 368 TQIDMWGVGCIFFEMA-SGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYN 426
T IDMW GCIF E+A +GRPLFPG+ V+D+L IFRLLGTP++E WP ++ ++K Y
Sbjct: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY- 239
Query: 427 FPKY-KPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGP 478
P Y L+N P+L++ G +L+ L+ +R+SAEEA++H YF P
Sbjct: 240 -PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 333 bits (854), Expect = 2e-91
Identities = 162/295 (54%), Positives = 215/295 (72%), Gaps = 4/295 (1%)
Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLE-HEEGAPCTAIREVSLLKDLKH 247
ME Y K+EK+GEGTY VYKGR K T +VA+K+IRLE EEG P TAIRE+SLLK+L+H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDC--GNIMSMHNVKLFLYQILRGLAYCH 305
NIV+L D++ D L L+FE+L DLK+Y+D G M VK +LYQIL+G+ +CH
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 306 RRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSE 365
R+VLHRDLKPQNLLI++KG +KLADFGLARA +P + Y++EVVTLWYR P+VLLGS+
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180
Query: 366 YSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNY 425
YST +D+W +G IF E+A+ +PLF G + D+L IFR LGTP+ E WP + S +++KN
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239
Query: 426 NFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
FPK+KP L +H LD G++L++K L Y+ KR+S + A+ H YF L +I
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 331 bits (849), Expect = 9e-91
Identities = 160/295 (54%), Positives = 214/295 (72%), Gaps = 4/295 (1%)
Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLE-HEEGAPCTAIREVSLLKDLKH 247
ME Y K+EK+GEGTY VYKGR K T +VA+K+IRLE EEG P TAIRE+SLLK+L+H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDC--GNIMSMHNVKLFLYQILRGLAYCH 305
NIV+L D++ D L L+FE+L DLK+Y+D G M VK +LYQIL+G+ +CH
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 306 RRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSE 365
R+VLHRDLKPQNLLI++KG +KLADFGLARA +P + Y++E +TLWYR P+VLLGS+
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSAR 180
Query: 366 YSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNY 425
YST +D+W +G IF E+A+ +PLF G + D+L IFR LGTP+ E WP + S +++KN
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239
Query: 426 NFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
FPK+KP L +H LD G++L++K L Y+ KR+S + A+ H YF L +I
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 325 bits (833), Expect = 6e-89
Identities = 156/292 (53%), Positives = 220/292 (75%), Gaps = 3/292 (1%)
Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 247
M+ + K+EK+GEGTY VYK +++ T LVALK+IRL+ E EG P TAIRE+SLLK+LKH
Sbjct: 1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60
Query: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDC-GNIMSMHNVKLFLYQILRGLAYCHR 306
NIV L D+VH ++ L LVFE+L +DLK+YMD G+ + +H +K +L+Q+L+G+++CH
Sbjct: 61 PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS 120
Query: 307 RKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEY 366
+V+HRDLKPQNLLINE G +KLADFGLARA VP +TY++EVVTLWYR P++LLGS Y
Sbjct: 121 HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFY 180
Query: 367 STQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYN 426
+T +D+W +GCIF EM + + LFPG + D+L IFR+LGTPS++TWPG++ ++K +
Sbjct: 181 TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG-S 239
Query: 427 FPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGP 478
FPK+ + L P L+ EG +L+ + LQY+ +R++A+ A+ H YF S P
Sbjct: 240 FPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEP 291
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 316 bits (809), Expect = 4e-86
Identities = 155/290 (53%), Positives = 211/290 (72%), Gaps = 3/290 (1%)
Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 247
ME + K+EK+GEGTY VYK R+KLT +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNI-MSMHNVKLFLYQILRGLAYCHR 306
NIV L D++HT+ L LVFE+L +DLK++MD + + +K +L+Q+L+GLA+CH
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 307 RKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEY 366
+VLHRDLKPQNLLIN +G +KLADFGLARA VP +TY++EVVTLWYR P++LLG Y
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
Query: 367 STQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYN 426
ST +D+W +GCIF EM + R LFPG + D+L IFR LGTP + WPG++S ++K +
Sbjct: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239
Query: 427 FPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSL 476
FPK+ Q P LD +G L+++ L Y+ KR+SA+ A+ H +F+ +
Sbjct: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289
>gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]
Length = 264
Score = 249 bits (636), Expect = 4e-66
Identities = 134/290 (46%), Positives = 185/290 (63%), Gaps = 37/290 (12%)
Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 247
ME + K+EK+GEGTY VYK R+KLT +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNI-MSMHNVKLFLYQILRGLAYCHR 306
NIV L D++HT+ L LVFE+L +DLK++MD + + +K +L+Q+L+GLA+CH
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 307 RKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEY 366
+VLHRDLKPQNLLIN +G +KLADFGLARA VP +TY++EV
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV----------------- 163
Query: 367 STQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYN 426
+ R LFPG + D+L IFR LGTP + WPG++S ++K +
Sbjct: 164 -----------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 205
Query: 427 FPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSL 476
FPK+ Q P LD +G L+++ L Y+ KR+SA+ A+ H +F+ +
Sbjct: 206 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 255
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 241 bits (614), Expect = 2e-63
Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)
Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
G +E + L ++ EGTY VY+ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 407 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 466
Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
+H NIVT+ +IV + DK + +V Y++ DLK M+ VK + Q+LRG
Sbjct: 467 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 525
Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++L
Sbjct: 526 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 585
Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
LG+ EYST +DMW VGCIF E+ + +PLFPG + D+++ +F+ LGTPS++ WPG S
Sbjct: 586 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 645
Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
K F ++ L L +G +L+ KFL Y +R+SAE+ +KH YFR
Sbjct: 646 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 700
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 241 bits (614), Expect = 2e-63
Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)
Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
G +E + L ++ EGTY VY+ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 416 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 475
Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
+H NIVT+ +IV + DK + +V Y++ DLK M+ VK + Q+LRG
Sbjct: 476 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 534
Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++L
Sbjct: 535 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 594
Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
LG+ EYST +DMW VGCIF E+ + +PLFPG + D+++ +F+ LGTPS++ WPG S
Sbjct: 595 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 654
Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
K F ++ L L +G +L+ KFL Y +R+SAE+ +KH YFR
Sbjct: 655 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 709
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 241 bits (614), Expect = 2e-63
Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)
Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
G +E + L ++ EGTY VY+ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 384 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 443
Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
+H NIVT+ +IV + DK + +V Y++ DLK M+ VK + Q+LRG
Sbjct: 444 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 502
Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++L
Sbjct: 503 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 562
Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
LG+ EYST +DMW VGCIF E+ + +PLFPG + D+++ +F+ LGTPS++ WPG S
Sbjct: 563 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 622
Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
K F ++ L L +G +L+ KFL Y +R+SAE+ +KH YFR
Sbjct: 623 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 677
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 241 bits (614), Expect = 2e-63
Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)
Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
G +E + L ++ EGTY VY+ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 373 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 432
Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
+H NIVT+ +IV + DK + +V Y++ DLK M+ VK + Q+LRG
Sbjct: 433 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 491
Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++L
Sbjct: 492 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 551
Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
LG+ EYST +DMW VGCIF E+ + +PLFPG + D+++ +F+ LGTPS++ WPG S
Sbjct: 552 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 611
Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
K F ++ L L +G +L+ KFL Y +R+SAE+ +KH YFR
Sbjct: 612 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 666
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 241 bits (614), Expect = 2e-63
Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)
Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
G +E + L ++ EGTY VY+ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 162 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 221
Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
+H NIVT+ +IV + DK + +V Y++ DLK M+ VK + Q+LRG
Sbjct: 222 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 280
Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++L
Sbjct: 281 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 340
Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
LG+ EYST +DMW VGCIF E+ + +PLFPG + D+++ +F+ LGTPS++ WPG S
Sbjct: 341 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 400
Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
K F ++ L L +G +L+ KFL Y +R+SAE+ +KH YFR
Sbjct: 401 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 455
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 241 bits (614), Expect = 2e-63
Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)
Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
G +E + L ++ EGTY VY+ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 418 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 477
Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
+H NIVT+ +IV + DK + +V Y++ DLK M+ VK + Q+LRG
Sbjct: 478 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 536
Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++L
Sbjct: 537 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 596
Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
LG+ EYST +DMW VGCIF E+ + +PLFPG + D+++ +F+ LGTPS++ WPG S
Sbjct: 597 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 656
Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
K F ++ L L +G +L+ KFL Y +R+SAE+ +KH YFR
Sbjct: 657 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 711
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 239 bits (609), Expect = 6e-63
Identities = 124/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)
Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
G +E + L ++ EGTY VY+ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 406 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 465
Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
+H NIVT+ +IV + DK + +V Y++ DLK M+ VK + Q+LRG
Sbjct: 466 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 524
Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y+ VVT WYR P++L
Sbjct: 525 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELL 584
Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
LG+ EYST +DMW VGCIF E+ + +PLFPG++ D+++ +F+ LGTPS++ WPG S
Sbjct: 585 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELP 644
Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
K F ++ L L +G +L+ KFL Y +R+SAE+ +KH YFR
Sbjct: 645 VVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 699
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 239 bits (609), Expect = 6e-63
Identities = 124/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)
Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
G +E + L ++ EGTY VY+ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 416 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 475
Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
+H NIVT+ +IV + DK + +V Y++ DLK M+ VK + Q+LRG
Sbjct: 476 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 534
Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y+ VVT WYR P++L
Sbjct: 535 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELL 594
Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
LG+ EYST +DMW VGCIF E+ + +PLFPG++ D+++ +F+ LGTPS++ WPG S
Sbjct: 595 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELP 654
Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
K F ++ L L +G +L+ KFL Y +R+SAE+ +KH YFR
Sbjct: 655 VVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 709
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 236 bits (603), Expect = 3e-62
Identities = 131/334 (39%), Positives = 198/334 (59%), Gaps = 16/334 (4%)
Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 247
++ + KL ++GEGTY VY+ R T+ +VALK++R++ E +G P +++RE++LL L+H
Sbjct: 36 VKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRH 95
Query: 248 ANIVTLHDIVHTD--KSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCH 305
NIV L ++V + +S+ LV Y ++DL +++ S VK + Q+LRGL Y H
Sbjct: 96 PNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLH 155
Query: 306 RRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSE 365
R ++HRDLK NLL+ +KG +K ADFGLARA VP K + +VVTLWYR P++LLG++
Sbjct: 156 RNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTT 215
Query: 366 YSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNY 425
+T IDMW VGCI E+ + RPL PG++ ++ LI +LLGTPS+ WPG S Y
Sbjct: 216 QTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQY 275
Query: 426 NFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRIHALPE 485
+ K L + P L G+ L+ Y+ KKR +A + ++ YF+ + PE
Sbjct: 276 SLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKE--KPLPCEPE 333
Query: 486 SVSIFSLKEIQLQKDPGFRNS-SYPETGHGKNRR 518
+ F P RN + P T G+++R
Sbjct: 334 LMPTF----------PHHRNKRAAPATSEGQSKR 357
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 221 bits (564), Expect = 1e-57
Identities = 113/290 (38%), Positives = 177/290 (61%), Gaps = 6/290 (2%)
Query: 188 KMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEH----EEGAPCTAIREVSLLK 243
+ + Y KL+ LGEG +ATVYK R K T +VA+K+I+L H ++G TA+RE+ LL+
Sbjct: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67
Query: 244 DLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAY 303
+L H NI+ L D +++LVF++++ DL+ + D +++ ++K ++ L+GL Y
Sbjct: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127
Query: 304 CHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGS 363
H+ +LHRDLKP NLL++E G LKLADFGLA++ P + Y+++VVT WYR P++L G+
Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187
Query: 364 SEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFK 423
Y +DMW VGCI E+ P PG + D+L IF LGTP++E WP + S ++
Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY- 246
Query: 424 NYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYF 473
F + PL + + ++LI + R++A +A+K YF
Sbjct: 247 -VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295
>gi|11496279 male germ cell-associated kinase [Homo sapiens]
Length = 623
Score = 220 bits (561), Expect = 2e-57
Identities = 120/305 (39%), Positives = 179/305 (58%), Gaps = 6/305 (1%)
Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 248
M Y + +LG+GTY +V G+S + LVA+K ++ + C +REV LK L HA
Sbjct: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHA 60
Query: 249 NIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRK 308
N++ L +++ + L +FEY+ ++L Q M D + ++ +YQIL+GLA+ H+
Sbjct: 61 NVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120
Query: 309 VLHRDLKPQNLLINEKGELKLADFGLAR-AKSVPTKTYSNEVVTLWYRPPDVLLGSSEYS 367
HRD+KP+NLL +K+ADFGLAR +S P Y++ V T WYR P+VLL SS YS
Sbjct: 121 FFHRDMKPENLLCMGPELVKIADFGLARELRSQP--PYTDYVSTRWYRAPEVLLRSSVYS 178
Query: 368 TQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNF 427
+ ID+W VG I E+ RPLFPG++ DE+ I ++LGTP + WP N+ F
Sbjct: 179 SPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRF 238
Query: 428 PKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYF---RSLGPRIHALP 484
P+ P L P +E I+L+T+ L ++ KKR +A +A+KH YF + LGP + L
Sbjct: 239 PQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLE 298
Query: 485 ESVSI 489
S+
Sbjct: 299 SKQSL 303
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 217 bits (552), Expect = 2e-56
Identities = 130/385 (33%), Positives = 202/385 (52%), Gaps = 27/385 (7%)
Query: 118 DEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSP----PFDQPMS 173
D++ SP + + + LP +P G L P P QP
Sbjct: 640 DDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYK 699
Query: 174 RR---------SRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIR 224
+R RR + S+ G ++ + + +GEGTY VYK + K T LVALK++R
Sbjct: 700 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVR 759
Query: 225 LEHE-EGAPCTAIREVSLLKDLKHANIVTLHDIVHTDK-----------SLTLVFEYLDK 272
L++E EG P TAIRE+ +L+ L H ++V + +IV TDK + LVFEY+D
Sbjct: 760 LDNEKEGFPITAIREIKILRQLIHRSVVNMKEIV-TDKQDALDFKKDKGAFYLVFEYMDH 818
Query: 273 DLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADF 332
DL ++ S ++K F+ Q++ GL YCH++ LHRD+K N+L+N G++KLADF
Sbjct: 819 DLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADF 878
Query: 333 GLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPG 391
GLAR S ++ Y+N+V+TLWYRPP++LLG Y+ ID+W GCI E+ + +P+F
Sbjct: 879 GLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQA 938
Query: 392 STVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELIT 451
+ +L LI RL G+P WP + F K + L + S ++L+
Sbjct: 939 NLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLD 998
Query: 452 KFLQYESKKRVSAEEAMKHVYFRSL 476
L + KR +AE+ ++ + + +
Sbjct: 999 HMLTLDPSKRCTAEQTLQSDFLKDV 1023
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 217 bits (552), Expect = 2e-56
Identities = 130/385 (33%), Positives = 202/385 (52%), Gaps = 27/385 (7%)
Query: 118 DEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSP----PFDQPMS 173
D++ SP + + + LP +P G L P P QP
Sbjct: 640 DDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYK 699
Query: 174 RR---------SRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIR 224
+R RR + S+ G ++ + + +GEGTY VYK + K T LVALK++R
Sbjct: 700 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVR 759
Query: 225 LEHE-EGAPCTAIREVSLLKDLKHANIVTLHDIVHTDK-----------SLTLVFEYLDK 272
L++E EG P TAIRE+ +L+ L H ++V + +IV TDK + LVFEY+D
Sbjct: 760 LDNEKEGFPITAIREIKILRQLIHRSVVNMKEIV-TDKQDALDFKKDKGAFYLVFEYMDH 818
Query: 273 DLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADF 332
DL ++ S ++K F+ Q++ GL YCH++ LHRD+K N+L+N G++KLADF
Sbjct: 819 DLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADF 878
Query: 333 GLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPG 391
GLAR S ++ Y+N+V+TLWYRPP++LLG Y+ ID+W GCI E+ + +P+F
Sbjct: 879 GLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQA 938
Query: 392 STVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELIT 451
+ +L LI RL G+P WP + F K + L + S ++L+
Sbjct: 939 NLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLD 998
Query: 452 KFLQYESKKRVSAEEAMKHVYFRSL 476
L + KR +AE+ ++ + + +
Sbjct: 999 HMLTLDPSKRCTAEQTLQSDFLKDV 1023
>gi|27477122 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 214 bits (545), Expect = 2e-55
Identities = 111/287 (38%), Positives = 173/287 (60%), Gaps = 3/287 (1%)
Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 248
M Y + +LG+GTY +V GRS + L+A+K+++ + C +REV LK L HA
Sbjct: 1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHA 60
Query: 249 NIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRK 308
N+V L +++ + L +FEY+ ++L Q + + + ++ +YQIL+GLA+ H+
Sbjct: 61 NVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG 120
Query: 309 VLHRDLKPQNLLINEKGELKLADFGLAR-AKSVPTKTYSNEVVTLWYRPPDVLLGSSEYS 367
HRDLKP+NLL +K+ADFGLAR +S P Y++ V T WYR P+VLL S+ YS
Sbjct: 121 FFHRDLKPENLLCMGPELVKIADFGLAREIRSKP--PYTDYVSTRWYRAPEVLLRSTNYS 178
Query: 368 TQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNF 427
+ ID+W VGCI E+ + RPLFPG++ D + I ++LGTP + WP N+ +
Sbjct: 179 SPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRW 238
Query: 428 PKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
P+ P L P SE ++L+ LQ++ KKR +A +A+++ YF+
Sbjct: 239 PQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQ 285
>gi|7662388 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 214 bits (545), Expect = 2e-55
Identities = 111/287 (38%), Positives = 173/287 (60%), Gaps = 3/287 (1%)
Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 248
M Y + +LG+GTY +V GRS + L+A+K+++ + C +REV LK L HA
Sbjct: 1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHA 60
Query: 249 NIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRK 308
N+V L +++ + L +FEY+ ++L Q + + + ++ +YQIL+GLA+ H+
Sbjct: 61 NVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG 120
Query: 309 VLHRDLKPQNLLINEKGELKLADFGLAR-AKSVPTKTYSNEVVTLWYRPPDVLLGSSEYS 367
HRDLKP+NLL +K+ADFGLAR +S P Y++ V T WYR P+VLL S+ YS
Sbjct: 121 FFHRDLKPENLLCMGPELVKIADFGLAREIRSKP--PYTDYVSTRWYRAPEVLLRSTNYS 178
Query: 368 TQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNF 427
+ ID+W VGCI E+ + RPLFPG++ D + I ++LGTP + WP N+ +
Sbjct: 179 SPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRW 238
Query: 428 PKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
P+ P L P SE ++L+ LQ++ KKR +A +A+++ YF+
Sbjct: 239 PQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQ 285
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 214 bits (544), Expect = 2e-55
Identities = 113/294 (38%), Positives = 175/294 (59%), Gaps = 14/294 (4%)
Query: 198 LGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDI 256
+GEGTY VYK R K T +VALK++RL++E EG P TAIRE+ +L+ L H +I+ + +I
Sbjct: 711 IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 770
Query: 257 VHTDK-----------SLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCH 305
V TDK + LVFEY+D DL ++ + +++K F+ Q++ GL YCH
Sbjct: 771 V-TDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCH 829
Query: 306 RRKVLHRDLKPQNLLINEKGELKLADFGLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSS 364
++ LHRD+K N+L+N +G++KLADFGLAR S ++ Y+N+V+TLWYRPP++LLG
Sbjct: 830 KKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEE 889
Query: 365 EYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKN 424
Y+ ID+W GCI E+ + +P+F + +L LI R+ G+P WP + F
Sbjct: 890 RYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNT 949
Query: 425 YNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGP 478
K + L + + ++L L + KR +AE+A++ + R + P
Sbjct: 950 MKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEP 1003
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,683,227
Number of Sequences: 37866
Number of extensions: 1000851
Number of successful extensions: 4719
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 722
Number of HSP's successfully gapped in prelim test: 72
Number of HSP's that attempted gapping in prelim test: 2473
Number of HSP's gapped (non-prelim): 991
length of query: 523
length of database: 18,247,518
effective HSP length: 107
effective length of query: 416
effective length of database: 14,195,856
effective search space: 5905476096
effective search space used: 5905476096
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.