Guide to the Human Genome
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Search of human proteins with 37595545

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
         (523 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]                  1052   0.0  
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        716   0.0  
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]          716   0.0  
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]         652   0.0  
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]         645   0.0  
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]         645   0.0  
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]                    373   e-103
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]                   345   4e-95
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   338   7e-93
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             333   2e-91
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           331   9e-91
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   325   6e-89
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        316   4e-86
gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]       249   4e-66
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...   241   2e-63
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...   241   2e-63
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...   241   2e-63
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...   241   2e-63
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...   241   2e-63
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...   241   2e-63
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]    239   6e-63
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]    239   6e-63
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]      236   3e-62
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   221   1e-57
gi|11496279 male germ cell-associated kinase [Homo sapiens]           220   2e-57
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...   217   2e-56
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...   217   2e-56
gi|27477122 intestinal cell kinase [Homo sapiens]                     214   2e-55
gi|7662388 intestinal cell kinase [Homo sapiens]                      214   2e-55
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]    214   2e-55

>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
          Length = 523

 Score = 1052 bits (2720), Expect = 0.0
 Identities = 523/523 (100%), Positives = 523/523 (100%)

Query: 1   MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60
           MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ
Sbjct: 1   MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60

Query: 61  YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120
           YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV
Sbjct: 61  YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120

Query: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180
           QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS
Sbjct: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180

Query: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240
           LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS
Sbjct: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240

Query: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
           LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG
Sbjct: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300

Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
           LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL
Sbjct: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360

Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
           LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE
Sbjct: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420

Query: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
           EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI
Sbjct: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480

Query: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF 523
           HALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF
Sbjct: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF 523


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  716 bits (1849), Expect = 0.0
 Identities = 356/512 (69%), Positives = 424/512 (82%), Gaps = 30/512 (5%)

Query: 1   MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60
           MKK KR+LS+TLRG + ID++ +   EQ+ ++E+           G  P           
Sbjct: 10  MKKIKRQLSMTLRGGRGIDKT-NGAPEQIGLDESGGG-------GGSDPG---------- 51

Query: 61  YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120
                 + P R     +  + G   + P      +IVHE+LKMGSDGESDQAS TSSDEV
Sbjct: 52  ------EAPTRAAPGELRSARGPLSSAP------EIVHEDLKMGSDGESDQASATSSDEV 99

Query: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180
           QSP  V +RN   R+IS ED+NKRLSLPADIR+P+GYLEKL +NSP FD+P+SRR RR S
Sbjct: 100 QSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVS 159

Query: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240
           LSEIGFGK+ETYIKL+KLGEGTYATVYKG+SKLT+NLVALKEIRLEHEEGAPCTAIREVS
Sbjct: 160 LSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVS 219

Query: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
           LLKDLKHANIVTLHDI+HT+KSLTLVFEYLDKDLKQY+DDCGNI++MHNVKLFL+Q+LRG
Sbjct: 220 LLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRG 279

Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
           LAYCHR+KVLHRDLKPQNLLINE+GELKLADFGLARAKS+PTKTYSNEVVTLWYRPPD+L
Sbjct: 280 LAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDIL 339

Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
           LGS++YSTQIDMWGVGCIF+EMA+GRPLFPGSTVE++LH IFR+LGTP++ETWPGI SNE
Sbjct: 340 LGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNE 399

Query: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
           EFK YN+PKY+ + L++HAPRLDS+G +L+TK LQ+E + R+SAE+AMKH +F SLG RI
Sbjct: 400 EFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERI 459

Query: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETG 512
           H LP++ SIF+LKEIQLQK+   R+SS P++G
Sbjct: 460 HKLPDTTSIFALKEIQLQKEASLRSSSMPDSG 491


>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
          Length = 496

 Score =  716 bits (1849), Expect = 0.0
 Identities = 356/512 (69%), Positives = 424/512 (82%), Gaps = 30/512 (5%)

Query: 1   MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60
           MKK KR+LS+TLRG + ID++ +   EQ+ ++E+           G  P           
Sbjct: 4   MKKIKRQLSMTLRGGRGIDKT-NGAPEQIGLDESGGG-------GGSDPG---------- 45

Query: 61  YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120
                 + P R     +  + G   + P      +IVHE+LKMGSDGESDQAS TSSDEV
Sbjct: 46  ------EAPTRAAPGELRSARGPLSSAP------EIVHEDLKMGSDGESDQASATSSDEV 93

Query: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180
           QSP  V +RN   R+IS ED+NKRLSLPADIR+P+GYLEKL +NSP FD+P+SRR RR S
Sbjct: 94  QSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVS 153

Query: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240
           LSEIGFGK+ETYIKL+KLGEGTYATVYKG+SKLT+NLVALKEIRLEHEEGAPCTAIREVS
Sbjct: 154 LSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVS 213

Query: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
           LLKDLKHANIVTLHDI+HT+KSLTLVFEYLDKDLKQY+DDCGNI++MHNVKLFL+Q+LRG
Sbjct: 214 LLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRG 273

Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
           LAYCHR+KVLHRDLKPQNLLINE+GELKLADFGLARAKS+PTKTYSNEVVTLWYRPPD+L
Sbjct: 274 LAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDIL 333

Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
           LGS++YSTQIDMWGVGCIF+EMA+GRPLFPGSTVE++LH IFR+LGTP++ETWPGI SNE
Sbjct: 334 LGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNE 393

Query: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
           EFK YN+PKY+ + L++HAPRLDS+G +L+TK LQ+E + R+SAE+AMKH +F SLG RI
Sbjct: 394 EFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERI 453

Query: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETG 512
           H LP++ SIF+LKEIQLQK+   R+SS P++G
Sbjct: 454 HKLPDTTSIFALKEIQLQKEASLRSSSMPDSG 485


>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
          Length = 504

 Score =  652 bits (1681), Expect = 0.0
 Identities = 335/526 (63%), Positives = 402/526 (76%), Gaps = 33/526 (6%)

Query: 1   MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGR-PPTSHSMHSFLH 59
           MK FKRR SL++  ++TI+ESL+E  EQ     N   +N  +   GR PP   S  S   
Sbjct: 6   MKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECSTFS--- 62

Query: 60  QYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDE 119
             T S ++P    P        G      +N  R  +              +ASG    +
Sbjct: 63  -PTDSGEEPGQLSP--------GVQFQRRQNQRRFSM------------EVRASGALPRQ 101

Query: 120 VQSPTGVCLRNRIHRRISME----DLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRR 175
           V      C    +HRR +      D++KRLSLP DIR+P  +L+KLQ+ SP   +P+SR 
Sbjct: 102 VAG----CTHKGVHRRAAALQPDFDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRM 157

Query: 176 SRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTA 235
           SRRASLS+IGFGK+ETY+KL+KLGEGTYATV+KGRSKLTENLVALKEIRLEHEEGAPCTA
Sbjct: 158 SRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTA 217

Query: 236 IREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLY 295
           IREVSLLK+LKHANIVTLHD++HTD+SLTLVFEYLD DLKQY+D CGN+MSMHNVK+F++
Sbjct: 218 IREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMF 277

Query: 296 QILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYR 355
           Q+LRGLAYCH RK+LHRDLKPQNLLINE+GELKLADFGLARAKSVPTKTYSNEVVTLWYR
Sbjct: 278 QLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYR 337

Query: 356 PPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPG 415
           PPDVLLGS+EYST IDMWGVGCI +EMA+GRPLFPGSTV++ELHLIFRLLGTP++ETWPG
Sbjct: 338 PPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPG 397

Query: 416 ISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRS 475
           +++  EF+ Y+FP Y PQPLINHAPRLD++GI L++  L YESK R+SAE A+ H YFRS
Sbjct: 398 VTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRS 457

Query: 476 LGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSM 521
           LG R+H L ++ SIFSLKEIQLQKDPG+R  ++ + G GKNRRQS+
Sbjct: 458 LGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSI 503


>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
          Length = 474

 Score =  645 bits (1665), Expect = 0.0
 Identities = 331/521 (63%), Positives = 396/521 (76%), Gaps = 53/521 (10%)

Query: 1   MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60
           MK FKRR SL++  ++TI+ESL+E                                    
Sbjct: 6   MKNFKRRFSLSVPRTETIEESLAE------------------------------------ 29

Query: 61  YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120
           +T  F +   RR  ++  G LG     P+  S            S  +S +  G  S  V
Sbjct: 30  FTEQFNQLHNRRNENLQLGPLGR--DPPQECSTF----------SPTDSGEEPGQLSPGV 77

Query: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180
           Q       R +  RR SMED++KRLSLP DIR+P  +L+KLQ+ SP   +P+SR SRRAS
Sbjct: 78  QFQ-----RRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRAS 132

Query: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240
           LS+IGFGK+ETY+KL+KLGEGTYATV+KGRSKLTENLVALKEIRLEHEEGAPCTAIREVS
Sbjct: 133 LSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 192

Query: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
           LLK+LKHANIVTLHD++HTD+SLTLVFEYLD DLKQY+D CGN+MSMHNVK+F++Q+LRG
Sbjct: 193 LLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRG 252

Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
           LAYCH RK+LHRDLKPQNLLINE+GELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL
Sbjct: 253 LAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 312

Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
           LGS+EYST IDMWGVGCI +EMA+GRPLFPGSTV++ELHLIFRLLGTP++ETWPG+++  
Sbjct: 313 LGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFS 372

Query: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
           EF+ Y+FP Y PQPLINHAPRLD++GI L++  L YESK R+SAE A+ H YFRSLG R+
Sbjct: 373 EFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERV 432

Query: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSM 521
           H L ++ SIFSLKEIQLQKDPG+R  ++ + G GKNRRQS+
Sbjct: 433 HQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSI 473


>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
          Length = 474

 Score =  645 bits (1665), Expect = 0.0
 Identities = 331/521 (63%), Positives = 396/521 (76%), Gaps = 53/521 (10%)

Query: 1   MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60
           MK FKRR SL++  ++TI+ESL+E                                    
Sbjct: 6   MKNFKRRFSLSVPRTETIEESLAE------------------------------------ 29

Query: 61  YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120
           +T  F +   RR  ++  G LG     P+  S            S  +S +  G  S  V
Sbjct: 30  FTEQFNQLHNRRNENLQLGPLGR--DPPQECSTF----------SPTDSGEEPGQLSPGV 77

Query: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180
           Q       R +  RR SMED++KRLSLP DIR+P  +L+KLQ+ SP   +P+SR SRRAS
Sbjct: 78  QFQ-----RRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRAS 132

Query: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240
           LS+IGFGK+ETY+KL+KLGEGTYATV+KGRSKLTENLVALKEIRLEHEEGAPCTAIREVS
Sbjct: 133 LSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 192

Query: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
           LLK+LKHANIVTLHD++HTD+SLTLVFEYLD DLKQY+D CGN+MSMHNVK+F++Q+LRG
Sbjct: 193 LLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRG 252

Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
           LAYCH RK+LHRDLKPQNLLINE+GELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL
Sbjct: 253 LAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 312

Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
           LGS+EYST IDMWGVGCI +EMA+GRPLFPGSTV++ELHLIFRLLGTP++ETWPG+++  
Sbjct: 313 LGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFS 372

Query: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
           EF+ Y+FP Y PQPLINHAPRLD++GI L++  L YESK R+SAE A+ H YFRSLG R+
Sbjct: 373 EFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERV 432

Query: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSM 521
           H L ++ SIFSLKEIQLQKDPG+R  ++ + G GKNRRQS+
Sbjct: 433 HQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSI 473


>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
          Length = 451

 Score =  373 bits (957), Expect = e-103
 Identities = 196/339 (57%), Positives = 241/339 (71%), Gaps = 17/339 (5%)

Query: 174 RRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPC 233
           R S  +S +   FGK ++Y KLEKLGEG+YATVYKG+SK+   LVALK IRL+ EEG P 
Sbjct: 99  RHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPF 158

Query: 234 TAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLF 293
           TAIRE SLLK LKHANIV LHDI+HT ++LTLVFEY+  DL QYMD     +   NVKLF
Sbjct: 159 TAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLF 218

Query: 294 LYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLW 353
           L+Q+LRGL+Y H+R +LHRDLKPQNLLI++ GELKLADFGLARAKSVP+ TYSNEVVTLW
Sbjct: 219 LFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLW 278

Query: 354 YRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPG-STVEDELHLIFRLLGTPSQET 412
           YRPPDVLLGS+EYST +DMWGVGCIF EM  G   FPG   ++D+L  IF +LGTP+++T
Sbjct: 279 YRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDT 338

Query: 413 WPGISSNEEFKNYNFPKYKPQPL---------INHAPRLDSEGIELITKFLQYESKKRVS 463
           WPG+ S   FK   F  Y  + L         +NHA        +L +K LQ   K R+S
Sbjct: 339 WPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAE-------DLASKLLQCSPKNRLS 391

Query: 464 AEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPG 502
           A+ A+ H YF  L PR+  L +  SIF++  ++LQ + G
Sbjct: 392 AQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAG 430


>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
          Length = 384

 Score =  345 bits (886), Expect = 4e-95
 Identities = 176/331 (53%), Positives = 236/331 (71%), Gaps = 3/331 (0%)

Query: 186 FGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDL 245
           FG   +Y+ LEKLGEG+YATVYKG S++   LVALK I +  EEG P TAIRE SLLK L
Sbjct: 46  FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105

Query: 246 KHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCH 305
           KHANIV LHDI+HT ++LT VFEY+  DL QYM      +  HNV+LF++Q+LRGLAY H
Sbjct: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165

Query: 306 RRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSE 365
            + VLHRDLKPQNLLI+  GELKLADFGLARAKS+P++TYS+EVVTLWYRPPD LLG++E
Sbjct: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225

Query: 366 YSTQIDMWGVGCIFFEMASGRPLFPG-STVEDELHLIFRLLGTPSQETWPGISSNEEFKN 424
           YS+++D+WG GCIF EM  G+PLFPG S + ++L  I+ +LG P+++TWPG+S    +  
Sbjct: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285

Query: 425 YNFPKYKPQPLINHAPRLD--SEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRIHA 482
             FP   P+ L     RL    E  +L ++ L+   + RVSA+EA+ H YF +L  +++ 
Sbjct: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345

Query: 483 LPESVSIFSLKEIQLQKDPGFRNSSYPETGH 513
           LP+  S+F++  ++L+ +     +SY +  H
Sbjct: 346 LPDEESLFTVSGVRLKPEMCDLLASYQKGHH 376


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  338 bits (867), Expect = 7e-93
 Identities = 165/293 (56%), Positives = 215/293 (73%), Gaps = 5/293 (1%)

Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 247
           M+ Y KLEK+GEGTY TV+K +++ T  +VALK +RL+ + EG P +A+RE+ LLK+LKH
Sbjct: 1   MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60

Query: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRR 307
            NIV LHD++H+DK LTLVFE+ D+DLK+Y D C   +    VK FL+Q+L+GL +CH R
Sbjct: 61  KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120

Query: 308 KVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYS 367
            VLHRDLKPQNLLIN  GELKLADFGLARA  +P + YS EVVTLWYRPPDVL G+  YS
Sbjct: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180

Query: 368 TQIDMWGVGCIFFEMA-SGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYN 426
           T IDMW  GCIF E+A +GRPLFPG+ V+D+L  IFRLLGTP++E WP ++   ++K Y 
Sbjct: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY- 239

Query: 427 FPKY-KPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGP 478
            P Y     L+N  P+L++ G +L+   L+    +R+SAEEA++H YF    P
Sbjct: 240 -PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  333 bits (854), Expect = 2e-91
 Identities = 162/295 (54%), Positives = 215/295 (72%), Gaps = 4/295 (1%)

Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLE-HEEGAPCTAIREVSLLKDLKH 247
           ME Y K+EK+GEGTY  VYKGR K T  +VA+K+IRLE  EEG P TAIRE+SLLK+L+H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDC--GNIMSMHNVKLFLYQILRGLAYCH 305
            NIV+L D++  D  L L+FE+L  DLK+Y+D    G  M    VK +LYQIL+G+ +CH
Sbjct: 61  PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120

Query: 306 RRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSE 365
            R+VLHRDLKPQNLLI++KG +KLADFGLARA  +P + Y++EVVTLWYR P+VLLGS+ 
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180

Query: 366 YSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNY 425
           YST +D+W +G IF E+A+ +PLF G +  D+L  IFR LGTP+ E WP + S +++KN 
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239

Query: 426 NFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
            FPK+KP  L +H   LD  G++L++K L Y+  KR+S + A+ H YF  L  +I
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  331 bits (849), Expect = 9e-91
 Identities = 160/295 (54%), Positives = 214/295 (72%), Gaps = 4/295 (1%)

Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLE-HEEGAPCTAIREVSLLKDLKH 247
           ME Y K+EK+GEGTY  VYKGR K T  +VA+K+IRLE  EEG P TAIRE+SLLK+L+H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDC--GNIMSMHNVKLFLYQILRGLAYCH 305
            NIV+L D++  D  L L+FE+L  DLK+Y+D    G  M    VK +LYQIL+G+ +CH
Sbjct: 61  PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120

Query: 306 RRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSE 365
            R+VLHRDLKPQNLLI++KG +KLADFGLARA  +P + Y++E +TLWYR P+VLLGS+ 
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSAR 180

Query: 366 YSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNY 425
           YST +D+W +G IF E+A+ +PLF G +  D+L  IFR LGTP+ E WP + S +++KN 
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239

Query: 426 NFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
            FPK+KP  L +H   LD  G++L++K L Y+  KR+S + A+ H YF  L  +I
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  325 bits (833), Expect = 6e-89
 Identities = 156/292 (53%), Positives = 220/292 (75%), Gaps = 3/292 (1%)

Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 247
           M+ + K+EK+GEGTY  VYK +++ T  LVALK+IRL+ E EG P TAIRE+SLLK+LKH
Sbjct: 1   MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60

Query: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDC-GNIMSMHNVKLFLYQILRGLAYCHR 306
            NIV L D+VH ++ L LVFE+L +DLK+YMD   G+ + +H +K +L+Q+L+G+++CH 
Sbjct: 61  PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS 120

Query: 307 RKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEY 366
            +V+HRDLKPQNLLINE G +KLADFGLARA  VP +TY++EVVTLWYR P++LLGS  Y
Sbjct: 121 HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFY 180

Query: 367 STQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYN 426
           +T +D+W +GCIF EM + + LFPG +  D+L  IFR+LGTPS++TWPG++   ++K  +
Sbjct: 181 TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG-S 239

Query: 427 FPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGP 478
           FPK+  + L    P L+ EG +L+ + LQY+  +R++A+ A+ H YF S  P
Sbjct: 240 FPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEP 291


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  316 bits (809), Expect = 4e-86
 Identities = 155/290 (53%), Positives = 211/290 (72%), Gaps = 3/290 (1%)

Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 247
           ME + K+EK+GEGTY  VYK R+KLT  +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60

Query: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNI-MSMHNVKLFLYQILRGLAYCHR 306
            NIV L D++HT+  L LVFE+L +DLK++MD      + +  +K +L+Q+L+GLA+CH 
Sbjct: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120

Query: 307 RKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEY 366
            +VLHRDLKPQNLLIN +G +KLADFGLARA  VP +TY++EVVTLWYR P++LLG   Y
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180

Query: 367 STQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYN 426
           ST +D+W +GCIF EM + R LFPG +  D+L  IFR LGTP +  WPG++S  ++K  +
Sbjct: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239

Query: 427 FPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSL 476
           FPK+  Q      P LD +G  L+++ L Y+  KR+SA+ A+ H +F+ +
Sbjct: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289


>gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]
          Length = 264

 Score =  249 bits (636), Expect = 4e-66
 Identities = 134/290 (46%), Positives = 185/290 (63%), Gaps = 37/290 (12%)

Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 247
           ME + K+EK+GEGTY  VYK R+KLT  +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60

Query: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNI-MSMHNVKLFLYQILRGLAYCHR 306
            NIV L D++HT+  L LVFE+L +DLK++MD      + +  +K +L+Q+L+GLA+CH 
Sbjct: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120

Query: 307 RKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEY 366
            +VLHRDLKPQNLLIN +G +KLADFGLARA  VP +TY++EV                 
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV----------------- 163

Query: 367 STQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYN 426
                            + R LFPG +  D+L  IFR LGTP +  WPG++S  ++K  +
Sbjct: 164 -----------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 205

Query: 427 FPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSL 476
           FPK+  Q      P LD +G  L+++ L Y+  KR+SA+ A+ H +F+ +
Sbjct: 206 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 255


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score =  241 bits (614), Expect = 2e-63
 Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)

Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
           G   +E +  L ++ EGTY  VY+ + K T+ +VALK +++E E EG P T++RE++ + 
Sbjct: 407 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 466

Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
             +H NIVT+ +IV   + DK + +V  Y++ DLK  M+          VK  + Q+LRG
Sbjct: 467 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 525

Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
           + + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  VVTLWYR P++L
Sbjct: 526 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 585

Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
           LG+ EYST +DMW VGCIF E+ + +PLFPG +  D+++ +F+ LGTPS++ WPG S   
Sbjct: 586 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 645

Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
             K   F ++    L       L  +G +L+ KFL Y   +R+SAE+ +KH YFR
Sbjct: 646 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 700


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score =  241 bits (614), Expect = 2e-63
 Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)

Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
           G   +E +  L ++ EGTY  VY+ + K T+ +VALK +++E E EG P T++RE++ + 
Sbjct: 416 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 475

Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
             +H NIVT+ +IV   + DK + +V  Y++ DLK  M+          VK  + Q+LRG
Sbjct: 476 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 534

Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
           + + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  VVTLWYR P++L
Sbjct: 535 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 594

Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
           LG+ EYST +DMW VGCIF E+ + +PLFPG +  D+++ +F+ LGTPS++ WPG S   
Sbjct: 595 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 654

Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
             K   F ++    L       L  +G +L+ KFL Y   +R+SAE+ +KH YFR
Sbjct: 655 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 709


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score =  241 bits (614), Expect = 2e-63
 Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)

Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
           G   +E +  L ++ EGTY  VY+ + K T+ +VALK +++E E EG P T++RE++ + 
Sbjct: 384 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 443

Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
             +H NIVT+ +IV   + DK + +V  Y++ DLK  M+          VK  + Q+LRG
Sbjct: 444 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 502

Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
           + + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  VVTLWYR P++L
Sbjct: 503 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 562

Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
           LG+ EYST +DMW VGCIF E+ + +PLFPG +  D+++ +F+ LGTPS++ WPG S   
Sbjct: 563 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 622

Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
             K   F ++    L       L  +G +L+ KFL Y   +R+SAE+ +KH YFR
Sbjct: 623 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 677


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score =  241 bits (614), Expect = 2e-63
 Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)

Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
           G   +E +  L ++ EGTY  VY+ + K T+ +VALK +++E E EG P T++RE++ + 
Sbjct: 373 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 432

Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
             +H NIVT+ +IV   + DK + +V  Y++ DLK  M+          VK  + Q+LRG
Sbjct: 433 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 491

Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
           + + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  VVTLWYR P++L
Sbjct: 492 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 551

Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
           LG+ EYST +DMW VGCIF E+ + +PLFPG +  D+++ +F+ LGTPS++ WPG S   
Sbjct: 552 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 611

Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
             K   F ++    L       L  +G +L+ KFL Y   +R+SAE+ +KH YFR
Sbjct: 612 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 666


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score =  241 bits (614), Expect = 2e-63
 Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)

Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
           G   +E +  L ++ EGTY  VY+ + K T+ +VALK +++E E EG P T++RE++ + 
Sbjct: 162 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 221

Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
             +H NIVT+ +IV   + DK + +V  Y++ DLK  M+          VK  + Q+LRG
Sbjct: 222 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 280

Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
           + + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  VVTLWYR P++L
Sbjct: 281 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 340

Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
           LG+ EYST +DMW VGCIF E+ + +PLFPG +  D+++ +F+ LGTPS++ WPG S   
Sbjct: 341 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 400

Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
             K   F ++    L       L  +G +L+ KFL Y   +R+SAE+ +KH YFR
Sbjct: 401 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 455


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score =  241 bits (614), Expect = 2e-63
 Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)

Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
           G   +E +  L ++ EGTY  VY+ + K T+ +VALK +++E E EG P T++RE++ + 
Sbjct: 418 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 477

Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
             +H NIVT+ +IV   + DK + +V  Y++ DLK  M+          VK  + Q+LRG
Sbjct: 478 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 536

Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
           + + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  VVTLWYR P++L
Sbjct: 537 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 596

Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
           LG+ EYST +DMW VGCIF E+ + +PLFPG +  D+++ +F+ LGTPS++ WPG S   
Sbjct: 597 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 656

Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
             K   F ++    L       L  +G +L+ KFL Y   +R+SAE+ +KH YFR
Sbjct: 657 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 711


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score =  239 bits (609), Expect = 6e-63
 Identities = 124/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)

Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
           G   +E +  L ++ EGTY  VY+ + K T+ +VALK +++E E EG P T++RE++ + 
Sbjct: 406 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 465

Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
             +H NIVT+ +IV   + DK + +V  Y++ DLK  M+          VK  + Q+LRG
Sbjct: 466 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 524

Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
           + + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  VVT WYR P++L
Sbjct: 525 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELL 584

Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
           LG+ EYST +DMW VGCIF E+ + +PLFPG++  D+++ +F+ LGTPS++ WPG S   
Sbjct: 585 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELP 644

Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
             K   F ++    L       L  +G +L+ KFL Y   +R+SAE+ +KH YFR
Sbjct: 645 VVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 699


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score =  239 bits (609), Expect = 6e-63
 Identities = 124/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)

Query: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
           G   +E +  L ++ EGTY  VY+ + K T+ +VALK +++E E EG P T++RE++ + 
Sbjct: 416 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 475

Query: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
             +H NIVT+ +IV   + DK + +V  Y++ DLK  M+          VK  + Q+LRG
Sbjct: 476 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 534

Query: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
           + + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  VVT WYR P++L
Sbjct: 535 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELL 594

Query: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
           LG+ EYST +DMW VGCIF E+ + +PLFPG++  D+++ +F+ LGTPS++ WPG S   
Sbjct: 595 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELP 654

Query: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
             K   F ++    L       L  +G +L+ KFL Y   +R+SAE+ +KH YFR
Sbjct: 655 VVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 709


>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
          Length = 360

 Score =  236 bits (603), Expect = 3e-62
 Identities = 131/334 (39%), Positives = 198/334 (59%), Gaps = 16/334 (4%)

Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 247
           ++ + KL ++GEGTY  VY+ R   T+ +VALK++R++ E +G P +++RE++LL  L+H
Sbjct: 36  VKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRH 95

Query: 248 ANIVTLHDIVHTD--KSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCH 305
            NIV L ++V  +  +S+ LV  Y ++DL   +++     S   VK  + Q+LRGL Y H
Sbjct: 96  PNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLH 155

Query: 306 RRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSE 365
           R  ++HRDLK  NLL+ +KG +K ADFGLARA  VP K  + +VVTLWYR P++LLG++ 
Sbjct: 156 RNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTT 215

Query: 366 YSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNY 425
            +T IDMW VGCI  E+ + RPL PG++   ++ LI +LLGTPS+  WPG S       Y
Sbjct: 216 QTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQY 275

Query: 426 NFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRIHALPE 485
           +  K     L +  P L   G+ L+     Y+ KKR +A + ++  YF+     +   PE
Sbjct: 276 SLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKE--KPLPCEPE 333

Query: 486 SVSIFSLKEIQLQKDPGFRNS-SYPETGHGKNRR 518
            +  F          P  RN  + P T  G+++R
Sbjct: 334 LMPTF----------PHHRNKRAAPATSEGQSKR 357


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  221 bits (564), Expect = 1e-57
 Identities = 113/290 (38%), Positives = 177/290 (61%), Gaps = 6/290 (2%)

Query: 188 KMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEH----EEGAPCTAIREVSLLK 243
           + + Y KL+ LGEG +ATVYK R K T  +VA+K+I+L H    ++G   TA+RE+ LL+
Sbjct: 8   RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67

Query: 244 DLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAY 303
           +L H NI+ L D      +++LVF++++ DL+  + D   +++  ++K ++   L+GL Y
Sbjct: 68  ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127

Query: 304 CHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGS 363
            H+  +LHRDLKP NLL++E G LKLADFGLA++   P + Y+++VVT WYR P++L G+
Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187

Query: 364 SEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFK 423
             Y   +DMW VGCI  E+    P  PG +  D+L  IF  LGTP++E WP + S  ++ 
Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY- 246

Query: 424 NYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYF 473
              F  +   PL +       + ++LI     +    R++A +A+K  YF
Sbjct: 247 -VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295


>gi|11496279 male germ cell-associated kinase [Homo sapiens]
          Length = 623

 Score =  220 bits (561), Expect = 2e-57
 Identities = 120/305 (39%), Positives = 179/305 (58%), Gaps = 6/305 (1%)

Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 248
           M  Y  + +LG+GTY +V  G+S  +  LVA+K ++ +      C  +REV  LK L HA
Sbjct: 1   MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHA 60

Query: 249 NIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRK 308
           N++ L +++  +  L  +FEY+ ++L Q M D   +     ++  +YQIL+GLA+ H+  
Sbjct: 61  NVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120

Query: 309 VLHRDLKPQNLLINEKGELKLADFGLAR-AKSVPTKTYSNEVVTLWYRPPDVLLGSSEYS 367
             HRD+KP+NLL      +K+ADFGLAR  +S P   Y++ V T WYR P+VLL SS YS
Sbjct: 121 FFHRDMKPENLLCMGPELVKIADFGLARELRSQP--PYTDYVSTRWYRAPEVLLRSSVYS 178

Query: 368 TQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNF 427
           + ID+W VG I  E+   RPLFPG++  DE+  I ++LGTP +  WP         N+ F
Sbjct: 179 SPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRF 238

Query: 428 PKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYF---RSLGPRIHALP 484
           P+  P  L    P   +E I+L+T+ L ++ KKR +A +A+KH YF   + LGP  + L 
Sbjct: 239 PQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLE 298

Query: 485 ESVSI 489
              S+
Sbjct: 299 SKQSL 303


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score =  217 bits (552), Expect = 2e-56
 Identities = 130/385 (33%), Positives = 202/385 (52%), Gaps = 27/385 (7%)

Query: 118  DEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSP----PFDQPMS 173
            D++ SP        + +       +    LP    +P G L       P    P  QP  
Sbjct: 640  DDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYK 699

Query: 174  RR---------SRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIR 224
            +R          RR + S+ G   ++ +  +  +GEGTY  VYK + K T  LVALK++R
Sbjct: 700  KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVR 759

Query: 225  LEHE-EGAPCTAIREVSLLKDLKHANIVTLHDIVHTDK-----------SLTLVFEYLDK 272
            L++E EG P TAIRE+ +L+ L H ++V + +IV TDK           +  LVFEY+D 
Sbjct: 760  LDNEKEGFPITAIREIKILRQLIHRSVVNMKEIV-TDKQDALDFKKDKGAFYLVFEYMDH 818

Query: 273  DLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADF 332
            DL   ++      S  ++K F+ Q++ GL YCH++  LHRD+K  N+L+N  G++KLADF
Sbjct: 819  DLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADF 878

Query: 333  GLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPG 391
            GLAR   S  ++ Y+N+V+TLWYRPP++LLG   Y+  ID+W  GCI  E+ + +P+F  
Sbjct: 879  GLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQA 938

Query: 392  STVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELIT 451
            +    +L LI RL G+P    WP +     F      K   + L      + S  ++L+ 
Sbjct: 939  NLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLD 998

Query: 452  KFLQYESKKRVSAEEAMKHVYFRSL 476
              L  +  KR +AE+ ++  + + +
Sbjct: 999  HMLTLDPSKRCTAEQTLQSDFLKDV 1023


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score =  217 bits (552), Expect = 2e-56
 Identities = 130/385 (33%), Positives = 202/385 (52%), Gaps = 27/385 (7%)

Query: 118  DEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSP----PFDQPMS 173
            D++ SP        + +       +    LP    +P G L       P    P  QP  
Sbjct: 640  DDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYK 699

Query: 174  RR---------SRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIR 224
            +R          RR + S+ G   ++ +  +  +GEGTY  VYK + K T  LVALK++R
Sbjct: 700  KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVR 759

Query: 225  LEHE-EGAPCTAIREVSLLKDLKHANIVTLHDIVHTDK-----------SLTLVFEYLDK 272
            L++E EG P TAIRE+ +L+ L H ++V + +IV TDK           +  LVFEY+D 
Sbjct: 760  LDNEKEGFPITAIREIKILRQLIHRSVVNMKEIV-TDKQDALDFKKDKGAFYLVFEYMDH 818

Query: 273  DLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADF 332
            DL   ++      S  ++K F+ Q++ GL YCH++  LHRD+K  N+L+N  G++KLADF
Sbjct: 819  DLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADF 878

Query: 333  GLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPG 391
            GLAR   S  ++ Y+N+V+TLWYRPP++LLG   Y+  ID+W  GCI  E+ + +P+F  
Sbjct: 879  GLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQA 938

Query: 392  STVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELIT 451
            +    +L LI RL G+P    WP +     F      K   + L      + S  ++L+ 
Sbjct: 939  NLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLD 998

Query: 452  KFLQYESKKRVSAEEAMKHVYFRSL 476
              L  +  KR +AE+ ++  + + +
Sbjct: 999  HMLTLDPSKRCTAEQTLQSDFLKDV 1023


>gi|27477122 intestinal cell kinase [Homo sapiens]
          Length = 632

 Score =  214 bits (545), Expect = 2e-55
 Identities = 111/287 (38%), Positives = 173/287 (60%), Gaps = 3/287 (1%)

Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 248
           M  Y  + +LG+GTY +V  GRS  +  L+A+K+++ +      C  +REV  LK L HA
Sbjct: 1   MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHA 60

Query: 249 NIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRK 308
           N+V L +++  +  L  +FEY+ ++L Q + +   +     ++  +YQIL+GLA+ H+  
Sbjct: 61  NVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG 120

Query: 309 VLHRDLKPQNLLINEKGELKLADFGLAR-AKSVPTKTYSNEVVTLWYRPPDVLLGSSEYS 367
             HRDLKP+NLL      +K+ADFGLAR  +S P   Y++ V T WYR P+VLL S+ YS
Sbjct: 121 FFHRDLKPENLLCMGPELVKIADFGLAREIRSKP--PYTDYVSTRWYRAPEVLLRSTNYS 178

Query: 368 TQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNF 427
           + ID+W VGCI  E+ + RPLFPG++  D +  I ++LGTP +  WP         N+ +
Sbjct: 179 SPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRW 238

Query: 428 PKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
           P+  P  L    P   SE ++L+   LQ++ KKR +A +A+++ YF+
Sbjct: 239 PQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQ 285


>gi|7662388 intestinal cell kinase [Homo sapiens]
          Length = 632

 Score =  214 bits (545), Expect = 2e-55
 Identities = 111/287 (38%), Positives = 173/287 (60%), Gaps = 3/287 (1%)

Query: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 248
           M  Y  + +LG+GTY +V  GRS  +  L+A+K+++ +      C  +REV  LK L HA
Sbjct: 1   MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHA 60

Query: 249 NIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRK 308
           N+V L +++  +  L  +FEY+ ++L Q + +   +     ++  +YQIL+GLA+ H+  
Sbjct: 61  NVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG 120

Query: 309 VLHRDLKPQNLLINEKGELKLADFGLAR-AKSVPTKTYSNEVVTLWYRPPDVLLGSSEYS 367
             HRDLKP+NLL      +K+ADFGLAR  +S P   Y++ V T WYR P+VLL S+ YS
Sbjct: 121 FFHRDLKPENLLCMGPELVKIADFGLAREIRSKP--PYTDYVSTRWYRAPEVLLRSTNYS 178

Query: 368 TQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNF 427
           + ID+W VGCI  E+ + RPLFPG++  D +  I ++LGTP +  WP         N+ +
Sbjct: 179 SPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRW 238

Query: 428 PKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
           P+  P  L    P   SE ++L+   LQ++ KKR +A +A+++ YF+
Sbjct: 239 PQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQ 285


>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
          Length = 1512

 Score =  214 bits (544), Expect = 2e-55
 Identities = 113/294 (38%), Positives = 175/294 (59%), Gaps = 14/294 (4%)

Query: 198  LGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDI 256
            +GEGTY  VYK R K T  +VALK++RL++E EG P TAIRE+ +L+ L H +I+ + +I
Sbjct: 711  IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 770

Query: 257  VHTDK-----------SLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCH 305
            V TDK           +  LVFEY+D DL   ++      + +++K F+ Q++ GL YCH
Sbjct: 771  V-TDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCH 829

Query: 306  RRKVLHRDLKPQNLLINEKGELKLADFGLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSS 364
            ++  LHRD+K  N+L+N +G++KLADFGLAR   S  ++ Y+N+V+TLWYRPP++LLG  
Sbjct: 830  KKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEE 889

Query: 365  EYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKN 424
             Y+  ID+W  GCI  E+ + +P+F  +    +L LI R+ G+P    WP +     F  
Sbjct: 890  RYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNT 949

Query: 425  YNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGP 478
                K   + L      + +  ++L    L  +  KR +AE+A++  + R + P
Sbjct: 950  MKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEP 1003


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,683,227
Number of Sequences: 37866
Number of extensions: 1000851
Number of successful extensions: 4719
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 722
Number of HSP's successfully gapped in prelim test: 72
Number of HSP's that attempted gapping in prelim test: 2473
Number of HSP's gapped (non-prelim): 991
length of query: 523
length of database: 18,247,518
effective HSP length: 107
effective length of query: 416
effective length of database: 14,195,856
effective search space: 5905476096
effective search space used: 5905476096
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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