Search of human proteins with 35493860

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|35493860 otoferlin isoform d [Homo sapiens]
         (1230 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|35493860 otoferlin isoform d [Homo sapiens]                       2515   0.0  
gi|35493868 otoferlin isoform b [Homo sapiens]                       2482   0.0  
gi|35493853 otoferlin isoform c [Homo sapiens]                       2470   0.0  
gi|34740331 otoferlin isoform a [Homo sapiens]                       2470   0.0  
gi|119120884 fer-1-like 6 [Homo sapiens]                             1240   0.0  
gi|195976779 dysferlin isoform 1 [Homo sapiens]                       719   0.0  
gi|195976773 dysferlin isoform 5 [Homo sapiens]                       719   0.0  
gi|195976769 dysferlin isoform 6 [Homo sapiens]                       719   0.0  
gi|195976764 dysferlin isoform 14 [Homo sapiens]                      719   0.0  
gi|195976758 dysferlin isoform 11 [Homo sapiens]                      719   0.0  
gi|195976756 dysferlin isoform 10 [Homo sapiens]                      719   0.0  
gi|195976821 dysferlin isoform 2 [Homo sapiens]                       712   0.0  
gi|4503431 dysferlin isoform 8 [Homo sapiens]                         712   0.0  
gi|195976777 dysferlin isoform 3 [Homo sapiens]                       712   0.0  
gi|195976775 dysferlin isoform 4 [Homo sapiens]                       712   0.0  
gi|195976766 dysferlin isoform 7 [Homo sapiens]                       712   0.0  
gi|195976762 dysferlin isoform 13 [Homo sapiens]                      712   0.0  
gi|195976760 dysferlin isoform 12 [Homo sapiens]                      712   0.0  
gi|195976754 dysferlin isoform 9 [Homo sapiens]                       712   0.0  
gi|19718759 myoferlin isoform b [Homo sapiens]                        681   0.0  
gi|7305053 myoferlin isoform a [Homo sapiens]                         681   0.0  
gi|116642865 fer-1-like 5 isoform 1 [Homo sapiens]                    421   e-117
gi|164607133 fer-1-like 5 isoform 2 [Homo sapiens]                    414   e-115
gi|4759026 RAS protein activator like 1 [Homo sapiens]                 66   2e-10
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva...    55   5e-07
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva...    55   5e-07
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva...    55   5e-07
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva...    55   5e-07
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]      55   5e-07
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]      55   5e-07

>gi|35493860 otoferlin isoform d [Homo sapiens]
          Length = 1230

 Score = 2515 bits (6518), Expect = 0.0
 Identities = 1230/1230 (100%), Positives = 1230/1230 (100%)

Query: 1    MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 60
            MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ
Sbjct: 1    MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 60

Query: 61   QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 120
            QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS
Sbjct: 61   QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 120

Query: 121  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 180
            KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC
Sbjct: 121  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 180

Query: 181  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 240
            GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV
Sbjct: 181  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 240

Query: 241  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 300
            FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF
Sbjct: 241  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 300

Query: 301  MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 360
            MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP
Sbjct: 301  MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 360

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
            INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV
Sbjct: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR
Sbjct: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
            RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK
Sbjct: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
            KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG
Sbjct: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLH 660
            SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLH
Sbjct: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLH 660

Query: 661  TFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSN 720
            TFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSN
Sbjct: 661  TFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSN 720

Query: 721  DPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDI 780
            DPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDI
Sbjct: 721  DPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDI 780

Query: 781  EASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWR 840
            EASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWR
Sbjct: 781  EASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWR 840

Query: 841  DPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLA 900
            DPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLA
Sbjct: 841  DPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLA 900

Query: 901  LRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPR 960
            LRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPR
Sbjct: 901  LRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPR 960

Query: 961  KPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEG 1020
            KPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEG
Sbjct: 961  KPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEG 1020

Query: 1021 NFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAI 1080
            NFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAI
Sbjct: 1021 NFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAI 1080

Query: 1081 ELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKV 1140
            ELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKV
Sbjct: 1081 ELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKV 1140

Query: 1141 EAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLII 1200
            EAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLII
Sbjct: 1141 EAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLII 1200

Query: 1201 KIVLALLGLLMLGLFLYSLPGYMVKKLLGA 1230
            KIVLALLGLLMLGLFLYSLPGYMVKKLLGA
Sbjct: 1201 KIVLALLGLLMLGLFLYSLPGYMVKKLLGA 1230


>gi|35493868 otoferlin isoform b [Homo sapiens]
          Length = 1230

 Score = 2482 bits (6432), Expect = 0.0
 Identities = 1209/1230 (98%), Positives = 1222/1230 (99%)

Query: 1    MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 60
            MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ
Sbjct: 1    MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 60

Query: 61   QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 120
            QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS
Sbjct: 61   QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 120

Query: 121  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 180
            KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC
Sbjct: 121  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 180

Query: 181  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 240
            GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV
Sbjct: 181  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 240

Query: 241  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 300
            FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF
Sbjct: 241  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 300

Query: 301  MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 360
            MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP
Sbjct: 301  MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 360

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
            INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV
Sbjct: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR
Sbjct: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
            RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK
Sbjct: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
            KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG
Sbjct: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLH 660
            SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLH
Sbjct: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLH 660

Query: 661  TFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSN 720
            TFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSN
Sbjct: 661  TFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSN 720

Query: 721  DPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDI 780
            DPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDI
Sbjct: 721  DPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDI 780

Query: 781  EASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWR 840
            EASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWR
Sbjct: 781  EASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWR 840

Query: 841  DPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLA 900
            DPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLA
Sbjct: 841  DPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLA 900

Query: 901  LRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPR 960
            LRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPR
Sbjct: 901  LRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPR 960

Query: 961  KPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEG 1020
            KPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEG
Sbjct: 961  KPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEG 1020

Query: 1021 NFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAI 1080
            NFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAI
Sbjct: 1021 NFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAI 1080

Query: 1081 ELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKV 1140
            ELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKV
Sbjct: 1081 ELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKV 1140

Query: 1141 EAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLII 1200
            EAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDT+F+WFLNPLKS +Y +   Y+WL++
Sbjct: 1141 EAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLL 1200

Query: 1201 KIVLALLGLLMLGLFLYSLPGYMVKKLLGA 1230
            K++L LL LL+L LFLYS+PGY+VKK+LGA
Sbjct: 1201 KLLLLLLLLLLLALFLYSVPGYLVKKILGA 1230


>gi|35493853 otoferlin isoform c [Homo sapiens]
          Length = 1307

 Score = 2470 bits (6401), Expect = 0.0
 Identities = 1209/1250 (96%), Positives = 1222/1250 (97%), Gaps = 20/1250 (1%)

Query: 1    MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 60
            MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ
Sbjct: 58   MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 117

Query: 61   QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 120
            QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS
Sbjct: 118  QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 177

Query: 121  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 180
            KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC
Sbjct: 178  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 237

Query: 181  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 240
            GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV
Sbjct: 238  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 297

Query: 241  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 300
            FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF
Sbjct: 298  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 357

Query: 301  MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 360
            MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP
Sbjct: 358  MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 417

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
            INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV
Sbjct: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR
Sbjct: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537

Query: 481  RFIYRPPDRSAPSWNTT--------------------GEVVVTMEPEVPIKKLETMVKLD 520
            RFIYRPPDRSAPSWNTT                    GEVVVTMEPEVPIKKLETMVKLD
Sbjct: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 597

Query: 521  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 580
            ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE
Sbjct: 598  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 657

Query: 581  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 640
            PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE
Sbjct: 658  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 717

Query: 641  LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED 700
            LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED
Sbjct: 718  LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED 777

Query: 701  VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR 760
            VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR
Sbjct: 778  VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR 837

Query: 761  DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK 820
            DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK
Sbjct: 838  DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK 897

Query: 821  HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS 880
            HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS
Sbjct: 898  HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS 957

Query: 881  EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW 940
            EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW
Sbjct: 958  EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW 1017

Query: 941  VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK 1000
            VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK
Sbjct: 1018 VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK 1077

Query: 1001 GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR 1060
            GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR
Sbjct: 1078 GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR 1137

Query: 1061 LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK 1120
            LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK
Sbjct: 1138 LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK 1197

Query: 1121 GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWF 1180
            GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDT+F+WF
Sbjct: 1198 GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWF 1257

Query: 1181 LNPLKSIKYLICTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLLGA 1230
            LNPLKS +Y +   Y+WL++K++L LL LL+L LFLYS+PGY+VKK+LGA
Sbjct: 1258 LNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA 1307


>gi|34740331 otoferlin isoform a [Homo sapiens]
          Length = 1997

 Score = 2470 bits (6401), Expect = 0.0
 Identities = 1209/1250 (96%), Positives = 1222/1250 (97%), Gaps = 20/1250 (1%)

Query: 1    MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 60
            MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ
Sbjct: 748  MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 807

Query: 61   QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 120
            QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS
Sbjct: 808  QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 867

Query: 121  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 180
            KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC
Sbjct: 868  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 927

Query: 181  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 240
            GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV
Sbjct: 928  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 987

Query: 241  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 300
            FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF
Sbjct: 988  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 1047

Query: 301  MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 360
            MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP
Sbjct: 1048 MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 1107

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
            INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV
Sbjct: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR
Sbjct: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227

Query: 481  RFIYRPPDRSAPSWNTT--------------------GEVVVTMEPEVPIKKLETMVKLD 520
            RFIYRPPDRSAPSWNTT                    GEVVVTMEPEVPIKKLETMVKLD
Sbjct: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 1287

Query: 521  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 580
            ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE
Sbjct: 1288 ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 1347

Query: 581  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 640
            PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE
Sbjct: 1348 PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 1407

Query: 641  LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED 700
            LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED
Sbjct: 1408 LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED 1467

Query: 701  VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR 760
            VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR
Sbjct: 1468 VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR 1527

Query: 761  DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK 820
            DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK
Sbjct: 1528 DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK 1587

Query: 821  HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS 880
            HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS
Sbjct: 1588 HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS 1647

Query: 881  EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW 940
            EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW
Sbjct: 1648 EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW 1707

Query: 941  VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK 1000
            VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK
Sbjct: 1708 VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK 1767

Query: 1001 GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR 1060
            GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR
Sbjct: 1768 GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR 1827

Query: 1061 LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK 1120
            LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK
Sbjct: 1828 LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK 1887

Query: 1121 GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWF 1180
            GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDT+F+WF
Sbjct: 1888 GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWF 1947

Query: 1181 LNPLKSIKYLICTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLLGA 1230
            LNPLKS +Y +   Y+WL++K++L LL LL+L LFLYS+PGY+VKK+LGA
Sbjct: 1948 LNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA 1997



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 16/51 (31%), Positives = 26/51 (50%)

Query: 219 MYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNL 269
           M   +  F  ++  L DP+ +VFF  Q   T V   +  P W++ +VF +L
Sbjct: 437 MANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487


>gi|119120884 fer-1-like 6 [Homo sapiens]
          Length = 1857

 Score = 1240 bits (3208), Expect = 0.0
 Identities = 632/1285 (49%), Positives = 877/1285 (68%), Gaps = 104/1285 (8%)

Query: 1    MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 60
            +IK  +  PE +++ VL +       F+S A+K     ++T LD++RL  C +ELE M +
Sbjct: 617  LIKISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRLTLCWQELEAMCK 676

Query: 61   QAR-MLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVP 119
            +A+ +++ Q K+ +V + +   QNF++K+RFL DEPQH+IPD+FIWM+SNN+RVAYAR+ 
Sbjct: 677  EAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVFIWMLSNNRRVAYARIA 736

Query: 120  SKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFL 179
            SKDLL+S V  + GK C K+KT FLK PGKR    AGW+VQAKV++YLWLG  K     L
Sbjct: 737  SKDLLYSPVAGQMGKHCGKIKTHFLKPPGKR---PAGWSVQAKVDVYLWLGSIKHASAIL 793

Query: 180  CGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFAR 239
              LP G++   +++G G +  PP +L+Y ++  FQLRAHMYQAR L AADS+GLSDPFA+
Sbjct: 794  DNLPVGYEAEMSSKGAGTN-HPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAK 852

Query: 240  VFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKAD 299
            V F++  Q T+++++TL PTW+QML+F++L L+G+  EL + PP++V+E+YD D++GK +
Sbjct: 853  VTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPE 912

Query: 300  FMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLP 359
            ++G T A P+VK+AD+ Y PPR    L Y+ I+ GN + GDLLA FELLQ+ P+G   LP
Sbjct: 913  YLGATVAAPVVKLADQDYEPPR----LCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP 968

Query: 360  PINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKG 419
            P+  P   D   I PVP  IRPVLSKYRVEVLFWG+R++K+V L  VDRP+  IEC G+G
Sbjct: 969  PVEPP---DITQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGGQG 1025

Query: 420  VQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSL 479
            V+S +I +YK NPNF+     FEV+LPENELLHPPL+I VVD RAFGR TLVG++ ++ L
Sbjct: 1026 VKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYL 1085

Query: 480  RRFIYRPPDRSAP------------------SWNTTGEVVVTMEPE-----VPIKKLETM 516
            ++F+ +  +  AP                  +  ++G    + +P      V ++   T+
Sbjct: 1086 KQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPPTV 1145

Query: 517  VKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEE-----------------------E 553
            V   A ++  + VDV +     + +    A+EP ++                       E
Sbjct: 1146 VPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIADE 1205

Query: 554  PDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKE 613
              E+++DWWSKY+AS+                  +K +  N +G KG+ + K        
Sbjct: 1206 SAENVIDWWSKYYASLKKA---------------QKAKERNPKGKKGNTEAKPDEVVVDI 1250

Query: 614  E---KKKKTQSSGSGQGSEAPEKKKPKIDE------LKVYPKELESEFDNFEDWLHTFNL 664
            E   KKKK +            KKKPK D       L++Y  +LESEF+NFEDW+ TF L
Sbjct: 1251 EDGPKKKKDKML----------KKKPKDDGIPNLAILQIYDGDLESEFNNFEDWVKTFEL 1300

Query: 665  LRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPIN 724
             RGK+ +D+ G  + +R++G+FKGS C+YK P  +D S E        + QGIP N P+ 
Sbjct: 1301 FRGKSTEDDHG-LDGDRVIGKFKGSFCIYKSP--QDSSSEDS--GQLRIQQGIPPNHPVT 1355

Query: 725  VLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASF 784
            VL+RVY+V A +L PAD +GK+DPYI I+LGKT+I+D++ YI KQLNPVFG+SF+I+A+F
Sbjct: 1356 VLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATF 1415

Query: 785  PMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMK 844
            P ES+L++ +YD D++GTDDLIGETKIDLENRFYSKHRA CG+   Y   GYN WRD  K
Sbjct: 1416 PKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSK 1475

Query: 845  PSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEI-EDENGQRKPTDEHVALLALRH 903
            P++ILT+LCKD K+DGP+F P G++++ N+VF+G +   E++  +   + EH+AL  L  
Sbjct: 1476 PTEILTKLCKDNKLDGPYFHP-GKIQIGNQVFSGKTIFTEEDTDETVESYEHLALKVLHS 1534

Query: 904  WEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPK 963
            WEDIP  GCRLVPEH+ETRPL + DKPG+EQGRL++WVDMFP DMP PG P+DISPR+PK
Sbjct: 1535 WEDIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPK 1594

Query: 964  KYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFN 1023
             YELRV IWNT++V+LED++ FTG+KSSDI+V+GWLKG ++DKQ+TDVHY+SLTGEGNFN
Sbjct: 1595 GYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFN 1654

Query: 1024 WRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELD 1083
            WR+LFPF YL AE+++VI+K+E++FS ++ E K PA L LQ+WD +  S+DDFLG +E++
Sbjct: 1655 WRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMN 1714

Query: 1084 LNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAE 1143
            LN FPR AK+AK C +       +   +SIF+QKRV+GWWP      +   ELTGKVEAE
Sbjct: 1715 LNSFPRAAKSAKACDLAKFENASEETKISIFQQKRVRGWWPF-----SKSKELTGKVEAE 1769

Query: 1144 LHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIV 1203
             HL+TAEEAEKNPVG AR EP+PL KPNRPDT+F WF++P K + YLI   YK  II   
Sbjct: 1770 FHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAF 1829

Query: 1204 LALLGLLMLGLFLYSLPGYMVKKLL 1228
            + ++ ++ L LF+Y+LPG + ++++
Sbjct: 1830 ILIILIIFLVLFIYTLPGAISRRIV 1854



 Score = 35.4 bits (80), Expect = 0.34
 Identities = 32/130 (24%), Positives = 49/130 (37%), Gaps = 21/130 (16%)

Query: 219 MYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHEL 278
           M      F  DS  L DPF  V F  Q   T V      P W + ++F  +         
Sbjct: 263 MANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM--------- 313

Query: 279 RDDPPI---IVIEIYDQDSMGKADFMGRTFAKPLVKMA-----DEAYCPPRFPPQLEYYQ 330
              PP+   + I+++D+ SM   D    T    L K++     D+ + P   P  +  Y 
Sbjct: 314 --FPPLCRRVKIQVWDEGSMN--DVALATHFIDLKKISNEQDGDKGFLPTFGPAWINLYG 369

Query: 331 IYRGNATAGD 340
             R ++   D
Sbjct: 370 SPRNHSLMDD 379


>gi|195976779 dysferlin isoform 1 [Homo sapiens]
          Length = 2119

 Score =  719 bits (1856), Expect = 0.0
 Identities = 407/1057 (38%), Positives = 589/1057 (55%), Gaps = 128/1057 (12%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1158 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1217

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1218 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1270

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 360
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1271 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1327

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1328 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1384

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1385 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1444

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
             F+  P    +PS     + V  + P   +     ++ +D   E ++ + +A+       
Sbjct: 1445 SFLCDPYSAESPSPQGGPDDVSLLSPGEDV-----LIDID-DKEPLIPIQLADGLSSLAP 1498

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
                +   P     +E  +DWWSK+FASI        ++E  G  LE+            
Sbjct: 1499 TNTAS---PPSSPHEEEFIDWWSKFFASIG-------EREKCGSYLEKD----------- 1537

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELES--EFDNFEDW 658
                                                  D LKVY  +LE+   F+   D+
Sbjct: 1538 -------------------------------------FDTLKVYDTQLENVEAFEGLSDF 1560

Query: 659  LHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIP 718
             +TF L RGKT ++    TE+  ++G FKG   +Y  PLPED +           F  + 
Sbjct: 1561 CNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLPEDPA----IPMPPRQFHQLA 1610

Query: 719  SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
            +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  + D++NYI   L PVFGK F
Sbjct: 1611 AQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMF 1670

Query: 779  DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNI 838
            ++  + P+E  L + +YD+DL+  D+ IGET +DLENR  SK  A CG+ QTY   G N 
Sbjct: 1671 ELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQ 1730

Query: 839  WRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIED---ENGQRKPTDEH 895
            WRD ++PSQ+L   C+  +V  P +    RV   ++ ++   EIE     N    P +E 
Sbjct: 1731 WRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS-IEEIEAGRIPNPHLGPVEER 1788

Query: 896  VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPL 955
            +AL  L+           LVPEHVE+RPL +P +P IEQG+L++WVD+FP  +  PG P 
Sbjct: 1789 LALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPF 1840

Query: 956  DISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHS 1015
            +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V+GW+ G +E KQ TDVHY S
Sbjct: 1841 NITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRS 1899

Query: 1016 LTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADD 1075
            L GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE KIPAR+  QIWD D FS DD
Sbjct: 1900 LGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDD 1959

Query: 1076 FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIFKQKRVKGWWPLLARNENDEF 1134
            FLG+++LDLNR P+ AKTAK+C+++           VS+F+QK VKGWWP +A  E ++ 
Sbjct: 1960 FLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVA-EEGEKK 2018

Query: 1135 ELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLI 1191
             L GK+E  L ++   E E+ P G  R+EP+    LE P RPDT+F+WF +P K++K+++
Sbjct: 2019 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2078

Query: 1192 CTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLL 1228
              R++W II  ++  + LL L +F+Y+ P Y   KL+
Sbjct: 2079 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2115



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 62/162 (38%), Positives = 92/162 (56%), Gaps = 9/162 (5%)

Query: 18  EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 77
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L+  +    +   
Sbjct: 732 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAA 786

Query: 78  LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 136
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 787 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 846

Query: 137 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 178
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 847 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 885



 Score = 33.9 bits (76), Expect = 0.98
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 226 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 262
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 440 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 476



 Score = 30.8 bits (68), Expect = 8.3
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 747 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 805
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 449 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 506

Query: 806 IGETKIDL 813
           +  T + +
Sbjct: 507 VATTYLSM 514


>gi|195976773 dysferlin isoform 5 [Homo sapiens]
          Length = 2088

 Score =  719 bits (1856), Expect = 0.0
 Identities = 407/1057 (38%), Positives = 589/1057 (55%), Gaps = 128/1057 (12%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1127 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1186

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1187 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1239

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 360
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1240 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1296

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1297 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1353

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1354 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1413

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
             F+  P    +PS     + V  + P   +     ++ +D   E ++ + +A+       
Sbjct: 1414 SFLCDPYSAESPSPQGGPDDVSLLSPGEDV-----LIDID-DKEPLIPIQLADGLSSLAP 1467

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
                +   P     +E  +DWWSK+FASI        ++E  G  LE+            
Sbjct: 1468 TNTAS---PPSSPHEEEFIDWWSKFFASIG-------EREKCGSYLEKD----------- 1506

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELES--EFDNFEDW 658
                                                  D LKVY  +LE+   F+   D+
Sbjct: 1507 -------------------------------------FDTLKVYDTQLENVEAFEGLSDF 1529

Query: 659  LHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIP 718
             +TF L RGKT ++    TE+  ++G FKG   +Y  PLPED +           F  + 
Sbjct: 1530 CNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLPEDPA----IPMPPRQFHQLA 1579

Query: 719  SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
            +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  + D++NYI   L PVFGK F
Sbjct: 1580 AQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMF 1639

Query: 779  DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNI 838
            ++  + P+E  L + +YD+DL+  D+ IGET +DLENR  SK  A CG+ QTY   G N 
Sbjct: 1640 ELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQ 1699

Query: 839  WRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIED---ENGQRKPTDEH 895
            WRD ++PSQ+L   C+  +V  P +    RV   ++ ++   EIE     N    P +E 
Sbjct: 1700 WRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS-IEEIEAGRIPNPHLGPVEER 1757

Query: 896  VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPL 955
            +AL  L+           LVPEHVE+RPL +P +P IEQG+L++WVD+FP  +  PG P 
Sbjct: 1758 LALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPF 1809

Query: 956  DISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHS 1015
            +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V+GW+ G +E KQ TDVHY S
Sbjct: 1810 NITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRS 1868

Query: 1016 LTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADD 1075
            L GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE KIPAR+  QIWD D FS DD
Sbjct: 1869 LGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDD 1928

Query: 1076 FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIFKQKRVKGWWPLLARNENDEF 1134
            FLG+++LDLNR P+ AKTAK+C+++           VS+F+QK VKGWWP +A  E ++ 
Sbjct: 1929 FLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVA-EEGEKK 1987

Query: 1135 ELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLI 1191
             L GK+E  L ++   E E+ P G  R+EP+    LE P RPDT+F+WF +P K++K+++
Sbjct: 1988 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2047

Query: 1192 CTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLL 1228
              R++W II  ++  + LL L +F+Y+ P Y   KL+
Sbjct: 2048 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2084



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 62/162 (38%), Positives = 92/162 (56%), Gaps = 9/162 (5%)

Query: 18  EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 77
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L+  +    +   
Sbjct: 701 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAA 755

Query: 78  LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 136
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 756 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 815

Query: 137 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 178
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 816 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 854



 Score = 33.9 bits (76), Expect = 0.98
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 226 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 262
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 409 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 445



 Score = 30.8 bits (68), Expect = 8.3
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 747 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 805
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 418 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 475

Query: 806 IGETKIDL 813
           +  T + +
Sbjct: 476 VATTYLSM 483


>gi|195976769 dysferlin isoform 6 [Homo sapiens]
          Length = 2102

 Score =  719 bits (1856), Expect = 0.0
 Identities = 407/1057 (38%), Positives = 589/1057 (55%), Gaps = 128/1057 (12%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1141 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1200

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1201 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1253

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 360
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1254 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1310

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1311 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1367

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1368 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1427

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
             F+  P    +PS     + V  + P   +     ++ +D   E ++ + +A+       
Sbjct: 1428 SFLCDPYSAESPSPQGGPDDVSLLSPGEDV-----LIDID-DKEPLIPIQLADGLSSLAP 1481

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
                +   P     +E  +DWWSK+FASI        ++E  G  LE+            
Sbjct: 1482 TNTAS---PPSSPHEEEFIDWWSKFFASIG-------EREKCGSYLEKD----------- 1520

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELES--EFDNFEDW 658
                                                  D LKVY  +LE+   F+   D+
Sbjct: 1521 -------------------------------------FDTLKVYDTQLENVEAFEGLSDF 1543

Query: 659  LHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIP 718
             +TF L RGKT ++    TE+  ++G FKG   +Y  PLPED +           F  + 
Sbjct: 1544 CNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLPEDPA----IPMPPRQFHQLA 1593

Query: 719  SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
            +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  + D++NYI   L PVFGK F
Sbjct: 1594 AQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMF 1653

Query: 779  DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNI 838
            ++  + P+E  L + +YD+DL+  D+ IGET +DLENR  SK  A CG+ QTY   G N 
Sbjct: 1654 ELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQ 1713

Query: 839  WRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIED---ENGQRKPTDEH 895
            WRD ++PSQ+L   C+  +V  P +    RV   ++ ++   EIE     N    P +E 
Sbjct: 1714 WRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS-IEEIEAGRIPNPHLGPVEER 1771

Query: 896  VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPL 955
            +AL  L+           LVPEHVE+RPL +P +P IEQG+L++WVD+FP  +  PG P 
Sbjct: 1772 LALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPF 1823

Query: 956  DISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHS 1015
            +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V+GW+ G +E KQ TDVHY S
Sbjct: 1824 NITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRS 1882

Query: 1016 LTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADD 1075
            L GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE KIPAR+  QIWD D FS DD
Sbjct: 1883 LGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDD 1942

Query: 1076 FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIFKQKRVKGWWPLLARNENDEF 1134
            FLG+++LDLNR P+ AKTAK+C+++           VS+F+QK VKGWWP +A  E ++ 
Sbjct: 1943 FLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVA-EEGEKK 2001

Query: 1135 ELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLI 1191
             L GK+E  L ++   E E+ P G  R+EP+    LE P RPDT+F+WF +P K++K+++
Sbjct: 2002 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2061

Query: 1192 CTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLL 1228
              R++W II  ++  + LL L +F+Y+ P Y   KL+
Sbjct: 2062 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2098



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 62/162 (38%), Positives = 92/162 (56%), Gaps = 9/162 (5%)

Query: 18  EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 77
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L+  +    +   
Sbjct: 715 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAA 769

Query: 78  LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 136
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 770 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 829

Query: 137 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 178
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 830 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 868



 Score = 33.9 bits (76), Expect = 0.98
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 226 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 262
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 409 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 445



 Score = 30.8 bits (68), Expect = 8.3
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 747 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 805
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 418 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 475

Query: 806 IGETKIDL 813
           +  T + +
Sbjct: 476 VATTYLSM 483


>gi|195976764 dysferlin isoform 14 [Homo sapiens]
          Length = 2118

 Score =  719 bits (1856), Expect = 0.0
 Identities = 407/1057 (38%), Positives = 589/1057 (55%), Gaps = 128/1057 (12%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1157 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1216

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1217 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1269

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 360
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1270 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1326

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1327 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1383

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1384 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1443

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
             F+  P    +PS     + V  + P   +     ++ +D   E ++ + +A+       
Sbjct: 1444 SFLCDPYSAESPSPQGGPDDVSLLSPGEDV-----LIDID-DKEPLIPIQLADGLSSLAP 1497

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
                +   P     +E  +DWWSK+FASI        ++E  G  LE+            
Sbjct: 1498 TNTAS---PPSSPHEEEFIDWWSKFFASIG-------EREKCGSYLEKD----------- 1536

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELES--EFDNFEDW 658
                                                  D LKVY  +LE+   F+   D+
Sbjct: 1537 -------------------------------------FDTLKVYDTQLENVEAFEGLSDF 1559

Query: 659  LHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIP 718
             +TF L RGKT ++    TE+  ++G FKG   +Y  PLPED +           F  + 
Sbjct: 1560 CNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLPEDPA----IPMPPRQFHQLA 1609

Query: 719  SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
            +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  + D++NYI   L PVFGK F
Sbjct: 1610 AQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMF 1669

Query: 779  DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNI 838
            ++  + P+E  L + +YD+DL+  D+ IGET +DLENR  SK  A CG+ QTY   G N 
Sbjct: 1670 ELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQ 1729

Query: 839  WRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIED---ENGQRKPTDEH 895
            WRD ++PSQ+L   C+  +V  P +    RV   ++ ++   EIE     N    P +E 
Sbjct: 1730 WRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS-IEEIEAGRIPNPHLGPVEER 1787

Query: 896  VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPL 955
            +AL  L+           LVPEHVE+RPL +P +P IEQG+L++WVD+FP  +  PG P 
Sbjct: 1788 LALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPF 1839

Query: 956  DISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHS 1015
            +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V+GW+ G +E KQ TDVHY S
Sbjct: 1840 NITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRS 1898

Query: 1016 LTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADD 1075
            L GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE KIPAR+  QIWD D FS DD
Sbjct: 1899 LGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDD 1958

Query: 1076 FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIFKQKRVKGWWPLLARNENDEF 1134
            FLG+++LDLNR P+ AKTAK+C+++           VS+F+QK VKGWWP +A  E ++ 
Sbjct: 1959 FLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVA-EEGEKK 2017

Query: 1135 ELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLI 1191
             L GK+E  L ++   E E+ P G  R+EP+    LE P RPDT+F+WF +P K++K+++
Sbjct: 2018 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2077

Query: 1192 CTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLL 1228
              R++W II  ++  + LL L +F+Y+ P Y   KL+
Sbjct: 2078 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2114



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 62/162 (38%), Positives = 92/162 (56%), Gaps = 9/162 (5%)

Query: 18  EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 77
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L+  +    +   
Sbjct: 731 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAA 785

Query: 78  LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 136
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 786 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 845

Query: 137 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 178
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 846 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 884



 Score = 33.9 bits (76), Expect = 0.98
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 226 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 262
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 439 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 475



 Score = 30.8 bits (68), Expect = 8.3
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 747 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 805
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 448 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 505

Query: 806 IGETKIDL 813
           +  T + +
Sbjct: 506 VATTYLSM 513


>gi|195976758 dysferlin isoform 11 [Homo sapiens]
          Length = 2101

 Score =  719 bits (1856), Expect = 0.0
 Identities = 407/1057 (38%), Positives = 589/1057 (55%), Gaps = 128/1057 (12%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1140 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1199

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1200 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1252

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 360
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1253 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1309

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1310 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1366

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1367 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1426

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
             F+  P    +PS     + V  + P   +     ++ +D   E ++ + +A+       
Sbjct: 1427 SFLCDPYSAESPSPQGGPDDVSLLSPGEDV-----LIDID-DKEPLIPIQLADGLSSLAP 1480

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
                +   P     +E  +DWWSK+FASI        ++E  G  LE+            
Sbjct: 1481 TNTAS---PPSSPHEEEFIDWWSKFFASIG-------EREKCGSYLEKD----------- 1519

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELES--EFDNFEDW 658
                                                  D LKVY  +LE+   F+   D+
Sbjct: 1520 -------------------------------------FDTLKVYDTQLENVEAFEGLSDF 1542

Query: 659  LHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIP 718
             +TF L RGKT ++    TE+  ++G FKG   +Y  PLPED +           F  + 
Sbjct: 1543 CNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLPEDPA----IPMPPRQFHQLA 1592

Query: 719  SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
            +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  + D++NYI   L PVFGK F
Sbjct: 1593 AQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMF 1652

Query: 779  DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNI 838
            ++  + P+E  L + +YD+DL+  D+ IGET +DLENR  SK  A CG+ QTY   G N 
Sbjct: 1653 ELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQ 1712

Query: 839  WRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIED---ENGQRKPTDEH 895
            WRD ++PSQ+L   C+  +V  P +    RV   ++ ++   EIE     N    P +E 
Sbjct: 1713 WRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS-IEEIEAGRIPNPHLGPVEER 1770

Query: 896  VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPL 955
            +AL  L+           LVPEHVE+RPL +P +P IEQG+L++WVD+FP  +  PG P 
Sbjct: 1771 LALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPF 1822

Query: 956  DISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHS 1015
            +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V+GW+ G +E KQ TDVHY S
Sbjct: 1823 NITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRS 1881

Query: 1016 LTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADD 1075
            L GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE KIPAR+  QIWD D FS DD
Sbjct: 1882 LGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDD 1941

Query: 1076 FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIFKQKRVKGWWPLLARNENDEF 1134
            FLG+++LDLNR P+ AKTAK+C+++           VS+F+QK VKGWWP +A  E ++ 
Sbjct: 1942 FLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVA-EEGEKK 2000

Query: 1135 ELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLI 1191
             L GK+E  L ++   E E+ P G  R+EP+    LE P RPDT+F+WF +P K++K+++
Sbjct: 2001 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2060

Query: 1192 CTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLL 1228
              R++W II  ++  + LL L +F+Y+ P Y   KL+
Sbjct: 2061 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2097



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 62/162 (38%), Positives = 92/162 (56%), Gaps = 9/162 (5%)

Query: 18  EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 77
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L+  +    +   
Sbjct: 714 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAA 768

Query: 78  LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 136
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 769 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 828

Query: 137 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 178
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 829 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 867



 Score = 33.9 bits (76), Expect = 0.98
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 226 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 262
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 408 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 444



 Score = 30.8 bits (68), Expect = 8.3
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 747 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 805
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 417 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 474

Query: 806 IGETKIDL 813
           +  T + +
Sbjct: 475 VATTYLSM 482


>gi|195976756 dysferlin isoform 10 [Homo sapiens]
          Length = 2087

 Score =  719 bits (1856), Expect = 0.0
 Identities = 407/1057 (38%), Positives = 589/1057 (55%), Gaps = 128/1057 (12%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1126 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1185

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1186 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1238

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 360
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1239 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1295

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1296 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1352

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1353 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1412

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
             F+  P    +PS     + V  + P   +     ++ +D   E ++ + +A+       
Sbjct: 1413 SFLCDPYSAESPSPQGGPDDVSLLSPGEDV-----LIDID-DKEPLIPIQLADGLSSLAP 1466

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
                +   P     +E  +DWWSK+FASI        ++E  G  LE+            
Sbjct: 1467 TNTAS---PPSSPHEEEFIDWWSKFFASIG-------EREKCGSYLEKD----------- 1505

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELES--EFDNFEDW 658
                                                  D LKVY  +LE+   F+   D+
Sbjct: 1506 -------------------------------------FDTLKVYDTQLENVEAFEGLSDF 1528

Query: 659  LHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIP 718
             +TF L RGKT ++    TE+  ++G FKG   +Y  PLPED +           F  + 
Sbjct: 1529 CNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLPEDPA----IPMPPRQFHQLA 1578

Query: 719  SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
            +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  + D++NYI   L PVFGK F
Sbjct: 1579 AQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMF 1638

Query: 779  DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNI 838
            ++  + P+E  L + +YD+DL+  D+ IGET +DLENR  SK  A CG+ QTY   G N 
Sbjct: 1639 ELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQ 1698

Query: 839  WRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIED---ENGQRKPTDEH 895
            WRD ++PSQ+L   C+  +V  P +    RV   ++ ++   EIE     N    P +E 
Sbjct: 1699 WRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS-IEEIEAGRIPNPHLGPVEER 1756

Query: 896  VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPL 955
            +AL  L+           LVPEHVE+RPL +P +P IEQG+L++WVD+FP  +  PG P 
Sbjct: 1757 LALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPF 1808

Query: 956  DISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHS 1015
            +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V+GW+ G +E KQ TDVHY S
Sbjct: 1809 NITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRS 1867

Query: 1016 LTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADD 1075
            L GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE KIPAR+  QIWD D FS DD
Sbjct: 1868 LGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDD 1927

Query: 1076 FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIFKQKRVKGWWPLLARNENDEF 1134
            FLG+++LDLNR P+ AKTAK+C+++           VS+F+QK VKGWWP +A  E ++ 
Sbjct: 1928 FLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVA-EEGEKK 1986

Query: 1135 ELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLI 1191
             L GK+E  L ++   E E+ P G  R+EP+    LE P RPDT+F+WF +P K++K+++
Sbjct: 1987 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2046

Query: 1192 CTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLL 1228
              R++W II  ++  + LL L +F+Y+ P Y   KL+
Sbjct: 2047 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2083



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 62/162 (38%), Positives = 92/162 (56%), Gaps = 9/162 (5%)

Query: 18  EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 77
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L+  +    +   
Sbjct: 700 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAA 754

Query: 78  LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 136
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 755 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 814

Query: 137 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 178
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 815 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 853



 Score = 33.9 bits (76), Expect = 0.98
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 226 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 262
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 408 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 444



 Score = 30.8 bits (68), Expect = 8.3
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 747 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 805
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 417 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 474

Query: 806 IGETKIDL 813
           +  T + +
Sbjct: 475 VATTYLSM 482


>gi|195976821 dysferlin isoform 2 [Homo sapiens]
          Length = 2081

 Score =  712 bits (1839), Expect = 0.0
 Identities = 406/1057 (38%), Positives = 583/1057 (55%), Gaps = 149/1057 (14%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1141 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1200

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1201 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1253

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 360
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1254 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1310

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1311 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1367

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1368 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1427

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
             F+  P    +PS     + V  + P                 + ++ +D          
Sbjct: 1428 SFLCDPYSAESPSPQGGPDDVSLLSPG---------------EDVLIDID---------- 1462

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
                  +EP     +E  +DWWSK+FASI        ++E  G  LE+            
Sbjct: 1463 -----DKEPLIPIQEEEFIDWWSKFFASIG-------EREKCGSYLEKD----------- 1499

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELES--EFDNFEDW 658
                                                  D LKVY  +LE+   F+   D+
Sbjct: 1500 -------------------------------------FDTLKVYDTQLENVEAFEGLSDF 1522

Query: 659  LHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIP 718
             +TF L RGKT ++    TE+  ++G FKG   +Y  PLPED +           F  + 
Sbjct: 1523 CNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLPEDPA----IPMPPRQFHQLA 1572

Query: 719  SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
            +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  + D++NYI   L PVFGK F
Sbjct: 1573 AQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMF 1632

Query: 779  DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNI 838
            ++  + P+E  L + +YD+DL+  D+ IGET +DLENR  SK  A CG+ QTY   G N 
Sbjct: 1633 ELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQ 1692

Query: 839  WRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIED---ENGQRKPTDEH 895
            WRD ++PSQ+L   C+  +V  P +    RV   ++ ++   EIE     N    P +E 
Sbjct: 1693 WRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS-IEEIEAGRIPNPHLGPVEER 1750

Query: 896  VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPL 955
            +AL  L+           LVPEHVE+RPL +P +P IEQG+L++WVD+FP  +  PG P 
Sbjct: 1751 LALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPF 1802

Query: 956  DISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHS 1015
            +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V+GW+ G +E KQ TDVHY S
Sbjct: 1803 NITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRS 1861

Query: 1016 LTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADD 1075
            L GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE KIPAR+  QIWD D FS DD
Sbjct: 1862 LGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDD 1921

Query: 1076 FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIFKQKRVKGWWPLLARNENDEF 1134
            FLG+++LDLNR P+ AKTAK+C+++           VS+F+QK VKGWWP +A  E ++ 
Sbjct: 1922 FLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVA-EEGEKK 1980

Query: 1135 ELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLI 1191
             L GK+E  L ++   E E+ P G  R+EP+    LE P RPDT+F+WF +P K++K+++
Sbjct: 1981 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2040

Query: 1192 CTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLL 1228
              R++W II  ++  + LL L +F+Y+ P Y   KL+
Sbjct: 2041 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2077



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 62/162 (38%), Positives = 92/162 (56%), Gaps = 9/162 (5%)

Query: 18  EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 77
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L+  +    +   
Sbjct: 715 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAA 769

Query: 78  LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 136
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 770 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 829

Query: 137 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 178
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 830 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 868



 Score = 33.9 bits (76), Expect = 0.98
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 226 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 262
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 409 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 445



 Score = 30.8 bits (68), Expect = 8.3
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 747 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 805
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 418 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 475

Query: 806 IGETKIDL 813
           +  T + +
Sbjct: 476 VATTYLSM 483


>gi|4503431 dysferlin isoform 8 [Homo sapiens]
          Length = 2080

 Score =  712 bits (1839), Expect = 0.0
 Identities = 406/1057 (38%), Positives = 583/1057 (55%), Gaps = 149/1057 (14%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1140 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1199

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1200 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1252

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 360
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1253 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1309

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1310 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1366

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1367 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1426

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
             F+  P    +PS     + V  + P                 + ++ +D          
Sbjct: 1427 SFLCDPYSAESPSPQGGPDDVSLLSPG---------------EDVLIDID---------- 1461

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
                  +EP     +E  +DWWSK+FASI        ++E  G  LE+            
Sbjct: 1462 -----DKEPLIPIQEEEFIDWWSKFFASIG-------EREKCGSYLEKD----------- 1498

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELES--EFDNFEDW 658
                                                  D LKVY  +LE+   F+   D+
Sbjct: 1499 -------------------------------------FDTLKVYDTQLENVEAFEGLSDF 1521

Query: 659  LHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIP 718
             +TF L RGKT ++    TE+  ++G FKG   +Y  PLPED +           F  + 
Sbjct: 1522 CNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLPEDPA----IPMPPRQFHQLA 1571

Query: 719  SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
            +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  + D++NYI   L PVFGK F
Sbjct: 1572 AQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMF 1631

Query: 779  DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNI 838
            ++  + P+E  L + +YD+DL+  D+ IGET +DLENR  SK  A CG+ QTY   G N 
Sbjct: 1632 ELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQ 1691

Query: 839  WRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIED---ENGQRKPTDEH 895
            WRD ++PSQ+L   C+  +V  P +    RV   ++ ++   EIE     N    P +E 
Sbjct: 1692 WRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS-IEEIEAGRIPNPHLGPVEER 1749

Query: 896  VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPL 955
            +AL  L+           LVPEHVE+RPL +P +P IEQG+L++WVD+FP  +  PG P 
Sbjct: 1750 LALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPF 1801

Query: 956  DISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHS 1015
            +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V+GW+ G +E KQ TDVHY S
Sbjct: 1802 NITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRS 1860

Query: 1016 LTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADD 1075
            L GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE KIPAR+  QIWD D FS DD
Sbjct: 1861 LGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDD 1920

Query: 1076 FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIFKQKRVKGWWPLLARNENDEF 1134
            FLG+++LDLNR P+ AKTAK+C+++           VS+F+QK VKGWWP +A  E ++ 
Sbjct: 1921 FLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVA-EEGEKK 1979

Query: 1135 ELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLI 1191
             L GK+E  L ++   E E+ P G  R+EP+    LE P RPDT+F+WF +P K++K+++
Sbjct: 1980 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2039

Query: 1192 CTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLL 1228
              R++W II  ++  + LL L +F+Y+ P Y   KL+
Sbjct: 2040 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2076



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 62/162 (38%), Positives = 92/162 (56%), Gaps = 9/162 (5%)

Query: 18  EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 77
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L+  +    +   
Sbjct: 714 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAA 768

Query: 78  LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 136
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 769 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 828

Query: 137 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 178
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 829 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 867



 Score = 33.9 bits (76), Expect = 0.98
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 226 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 262
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 408 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 444



 Score = 30.8 bits (68), Expect = 8.3
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 747 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 805
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 417 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 474

Query: 806 IGETKIDL 813
           +  T + +
Sbjct: 475 VATTYLSM 482


>gi|195976777 dysferlin isoform 3 [Homo sapiens]
          Length = 2067

 Score =  712 bits (1839), Expect = 0.0
 Identities = 406/1057 (38%), Positives = 583/1057 (55%), Gaps = 149/1057 (14%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1127 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1186

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1187 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1239

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 360
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1240 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1296

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1297 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1353

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1354 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1413

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
             F+  P    +PS     + V  + P                 + ++ +D          
Sbjct: 1414 SFLCDPYSAESPSPQGGPDDVSLLSPG---------------EDVLIDID---------- 1448

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
                  +EP     +E  +DWWSK+FASI        ++E  G  LE+            
Sbjct: 1449 -----DKEPLIPIQEEEFIDWWSKFFASIG-------EREKCGSYLEKD----------- 1485

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELES--EFDNFEDW 658
                                                  D LKVY  +LE+   F+   D+
Sbjct: 1486 -------------------------------------FDTLKVYDTQLENVEAFEGLSDF 1508

Query: 659  LHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIP 718
             +TF L RGKT ++    TE+  ++G FKG   +Y  PLPED +           F  + 
Sbjct: 1509 CNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLPEDPA----IPMPPRQFHQLA 1558

Query: 719  SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
            +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  + D++NYI   L PVFGK F
Sbjct: 1559 AQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMF 1618

Query: 779  DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNI 838
            ++  + P+E  L + +YD+DL+  D+ IGET +DLENR  SK  A CG+ QTY   G N 
Sbjct: 1619 ELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQ 1678

Query: 839  WRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIED---ENGQRKPTDEH 895
            WRD ++PSQ+L   C+  +V  P +    RV   ++ ++   EIE     N    P +E 
Sbjct: 1679 WRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS-IEEIEAGRIPNPHLGPVEER 1736

Query: 896  VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPL 955
            +AL  L+           LVPEHVE+RPL +P +P IEQG+L++WVD+FP  +  PG P 
Sbjct: 1737 LALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPF 1788

Query: 956  DISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHS 1015
            +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V+GW+ G +E KQ TDVHY S
Sbjct: 1789 NITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRS 1847

Query: 1016 LTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADD 1075
            L GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE KIPAR+  QIWD D FS DD
Sbjct: 1848 LGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDD 1907

Query: 1076 FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIFKQKRVKGWWPLLARNENDEF 1134
            FLG+++LDLNR P+ AKTAK+C+++           VS+F+QK VKGWWP +A  E ++ 
Sbjct: 1908 FLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVA-EEGEKK 1966

Query: 1135 ELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLI 1191
             L GK+E  L ++   E E+ P G  R+EP+    LE P RPDT+F+WF +P K++K+++
Sbjct: 1967 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2026

Query: 1192 CTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLL 1228
              R++W II  ++  + LL L +F+Y+ P Y   KL+
Sbjct: 2027 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2063



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 62/162 (38%), Positives = 92/162 (56%), Gaps = 9/162 (5%)

Query: 18  EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 77
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L+  +    +   
Sbjct: 701 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAA 755

Query: 78  LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 136
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 756 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 815

Query: 137 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 178
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 816 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 854



 Score = 33.9 bits (76), Expect = 0.98
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 226 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 262
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 409 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 445



 Score = 30.8 bits (68), Expect = 8.3
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 747 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 805
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 418 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 475

Query: 806 IGETKIDL 813
           +  T + +
Sbjct: 476 VATTYLSM 483


>gi|195976775 dysferlin isoform 4 [Homo sapiens]
          Length = 2098

 Score =  712 bits (1839), Expect = 0.0
 Identities = 406/1057 (38%), Positives = 583/1057 (55%), Gaps = 149/1057 (14%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1158 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1217

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1218 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1270

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 360
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1271 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1327

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1328 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1384

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1385 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1444

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
             F+  P    +PS     + V  + P                 + ++ +D          
Sbjct: 1445 SFLCDPYSAESPSPQGGPDDVSLLSPG---------------EDVLIDID---------- 1479

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
                  +EP     +E  +DWWSK+FASI        ++E  G  LE+            
Sbjct: 1480 -----DKEPLIPIQEEEFIDWWSKFFASIG-------EREKCGSYLEKD----------- 1516

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELES--EFDNFEDW 658
                                                  D LKVY  +LE+   F+   D+
Sbjct: 1517 -------------------------------------FDTLKVYDTQLENVEAFEGLSDF 1539

Query: 659  LHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIP 718
             +TF L RGKT ++    TE+  ++G FKG   +Y  PLPED +           F  + 
Sbjct: 1540 CNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLPEDPA----IPMPPRQFHQLA 1589

Query: 719  SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
            +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  + D++NYI   L PVFGK F
Sbjct: 1590 AQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMF 1649

Query: 779  DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNI 838
            ++  + P+E  L + +YD+DL+  D+ IGET +DLENR  SK  A CG+ QTY   G N 
Sbjct: 1650 ELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQ 1709

Query: 839  WRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIED---ENGQRKPTDEH 895
            WRD ++PSQ+L   C+  +V  P +    RV   ++ ++   EIE     N    P +E 
Sbjct: 1710 WRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS-IEEIEAGRIPNPHLGPVEER 1767

Query: 896  VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPL 955
            +AL  L+           LVPEHVE+RPL +P +P IEQG+L++WVD+FP  +  PG P 
Sbjct: 1768 LALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPF 1819

Query: 956  DISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHS 1015
            +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V+GW+ G +E KQ TDVHY S
Sbjct: 1820 NITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRS 1878

Query: 1016 LTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADD 1075
            L GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE KIPAR+  QIWD D FS DD
Sbjct: 1879 LGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDD 1938

Query: 1076 FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIFKQKRVKGWWPLLARNENDEF 1134
            FLG+++LDLNR P+ AKTAK+C+++           VS+F+QK VKGWWP +A  E ++ 
Sbjct: 1939 FLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVA-EEGEKK 1997

Query: 1135 ELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLI 1191
             L GK+E  L ++   E E+ P G  R+EP+    LE P RPDT+F+WF +P K++K+++
Sbjct: 1998 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2057

Query: 1192 CTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLL 1228
              R++W II  ++  + LL L +F+Y+ P Y   KL+
Sbjct: 2058 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2094



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 62/162 (38%), Positives = 92/162 (56%), Gaps = 9/162 (5%)

Query: 18  EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 77
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L+  +    +   
Sbjct: 732 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAA 786

Query: 78  LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 136
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 787 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 846

Query: 137 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 178
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 847 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 885



 Score = 33.9 bits (76), Expect = 0.98
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 226 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 262
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 440 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 476



 Score = 30.8 bits (68), Expect = 8.3
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 747 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 805
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 449 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 506

Query: 806 IGETKIDL 813
           +  T + +
Sbjct: 507 VATTYLSM 514


>gi|195976766 dysferlin isoform 7 [Homo sapiens]
          Length = 2112

 Score =  712 bits (1839), Expect = 0.0
 Identities = 406/1057 (38%), Positives = 583/1057 (55%), Gaps = 149/1057 (14%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1172 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1231

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1232 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1284

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 360
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1285 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1341

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1342 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1398

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1399 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1458

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
             F+  P    +PS     + V  + P                 + ++ +D          
Sbjct: 1459 SFLCDPYSAESPSPQGGPDDVSLLSPG---------------EDVLIDID---------- 1493

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
                  +EP     +E  +DWWSK+FASI        ++E  G  LE+            
Sbjct: 1494 -----DKEPLIPIQEEEFIDWWSKFFASIG-------EREKCGSYLEKD----------- 1530

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELES--EFDNFEDW 658
                                                  D LKVY  +LE+   F+   D+
Sbjct: 1531 -------------------------------------FDTLKVYDTQLENVEAFEGLSDF 1553

Query: 659  LHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIP 718
             +TF L RGKT ++    TE+  ++G FKG   +Y  PLPED +           F  + 
Sbjct: 1554 CNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLPEDPA----IPMPPRQFHQLA 1603

Query: 719  SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
            +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  + D++NYI   L PVFGK F
Sbjct: 1604 AQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMF 1663

Query: 779  DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNI 838
            ++  + P+E  L + +YD+DL+  D+ IGET +DLENR  SK  A CG+ QTY   G N 
Sbjct: 1664 ELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQ 1723

Query: 839  WRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIED---ENGQRKPTDEH 895
            WRD ++PSQ+L   C+  +V  P +    RV   ++ ++   EIE     N    P +E 
Sbjct: 1724 WRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS-IEEIEAGRIPNPHLGPVEER 1781

Query: 896  VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPL 955
            +AL  L+           LVPEHVE+RPL +P +P IEQG+L++WVD+FP  +  PG P 
Sbjct: 1782 LALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPF 1833

Query: 956  DISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHS 1015
            +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V+GW+ G +E KQ TDVHY S
Sbjct: 1834 NITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRS 1892

Query: 1016 LTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADD 1075
            L GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE KIPAR+  QIWD D FS DD
Sbjct: 1893 LGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDD 1952

Query: 1076 FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIFKQKRVKGWWPLLARNENDEF 1134
            FLG+++LDLNR P+ AKTAK+C+++           VS+F+QK VKGWWP +A  E ++ 
Sbjct: 1953 FLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVA-EEGEKK 2011

Query: 1135 ELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLI 1191
             L GK+E  L ++   E E+ P G  R+EP+    LE P RPDT+F+WF +P K++K+++
Sbjct: 2012 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2071

Query: 1192 CTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLL 1228
              R++W II  ++  + LL L +F+Y+ P Y   KL+
Sbjct: 2072 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2108



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 62/162 (38%), Positives = 92/162 (56%), Gaps = 9/162 (5%)

Query: 18  EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 77
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L+  +    +   
Sbjct: 746 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAA 800

Query: 78  LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 136
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 801 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 860

Query: 137 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 178
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 861 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 899



 Score = 33.9 bits (76), Expect = 0.98
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 226 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 262
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 440 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 476



 Score = 30.8 bits (68), Expect = 8.3
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 747 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 805
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 449 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 506

Query: 806 IGETKIDL 813
           +  T + +
Sbjct: 507 VATTYLSM 514


>gi|195976762 dysferlin isoform 13 [Homo sapiens]
          Length = 2097

 Score =  712 bits (1839), Expect = 0.0
 Identities = 406/1057 (38%), Positives = 583/1057 (55%), Gaps = 149/1057 (14%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1157 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1216

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1217 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1269

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 360
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1270 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1326

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1327 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1383

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1384 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1443

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
             F+  P    +PS     + V  + P                 + ++ +D          
Sbjct: 1444 SFLCDPYSAESPSPQGGPDDVSLLSPG---------------EDVLIDID---------- 1478

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
                  +EP     +E  +DWWSK+FASI        ++E  G  LE+            
Sbjct: 1479 -----DKEPLIPIQEEEFIDWWSKFFASIG-------EREKCGSYLEKD----------- 1515

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELES--EFDNFEDW 658
                                                  D LKVY  +LE+   F+   D+
Sbjct: 1516 -------------------------------------FDTLKVYDTQLENVEAFEGLSDF 1538

Query: 659  LHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIP 718
             +TF L RGKT ++    TE+  ++G FKG   +Y  PLPED +           F  + 
Sbjct: 1539 CNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLPEDPA----IPMPPRQFHQLA 1588

Query: 719  SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
            +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  + D++NYI   L PVFGK F
Sbjct: 1589 AQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMF 1648

Query: 779  DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNI 838
            ++  + P+E  L + +YD+DL+  D+ IGET +DLENR  SK  A CG+ QTY   G N 
Sbjct: 1649 ELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQ 1708

Query: 839  WRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIED---ENGQRKPTDEH 895
            WRD ++PSQ+L   C+  +V  P +    RV   ++ ++   EIE     N    P +E 
Sbjct: 1709 WRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS-IEEIEAGRIPNPHLGPVEER 1766

Query: 896  VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPL 955
            +AL  L+           LVPEHVE+RPL +P +P IEQG+L++WVD+FP  +  PG P 
Sbjct: 1767 LALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPF 1818

Query: 956  DISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHS 1015
            +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V+GW+ G +E KQ TDVHY S
Sbjct: 1819 NITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRS 1877

Query: 1016 LTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADD 1075
            L GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE KIPAR+  QIWD D FS DD
Sbjct: 1878 LGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDD 1937

Query: 1076 FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIFKQKRVKGWWPLLARNENDEF 1134
            FLG+++LDLNR P+ AKTAK+C+++           VS+F+QK VKGWWP +A  E ++ 
Sbjct: 1938 FLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVA-EEGEKK 1996

Query: 1135 ELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLI 1191
             L GK+E  L ++   E E+ P G  R+EP+    LE P RPDT+F+WF +P K++K+++
Sbjct: 1997 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2056

Query: 1192 CTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLL 1228
              R++W II  ++  + LL L +F+Y+ P Y   KL+
Sbjct: 2057 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2093



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 62/162 (38%), Positives = 92/162 (56%), Gaps = 9/162 (5%)

Query: 18  EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 77
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L+  +    +   
Sbjct: 731 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAA 785

Query: 78  LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 136
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 786 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 845

Query: 137 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 178
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 846 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 884



 Score = 33.9 bits (76), Expect = 0.98
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 226 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 262
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 439 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 475



 Score = 30.8 bits (68), Expect = 8.3
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 747 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 805
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 448 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 505

Query: 806 IGETKIDL 813
           +  T + +
Sbjct: 506 VATTYLSM 513


>gi|195976760 dysferlin isoform 12 [Homo sapiens]
          Length = 2111

 Score =  712 bits (1839), Expect = 0.0
 Identities = 406/1057 (38%), Positives = 583/1057 (55%), Gaps = 149/1057 (14%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1171 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1230

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1231 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1283

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 360
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1284 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1340

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1341 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1397

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1398 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1457

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
             F+  P    +PS     + V  + P                 + ++ +D          
Sbjct: 1458 SFLCDPYSAESPSPQGGPDDVSLLSPG---------------EDVLIDID---------- 1492

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
                  +EP     +E  +DWWSK+FASI        ++E  G  LE+            
Sbjct: 1493 -----DKEPLIPIQEEEFIDWWSKFFASIG-------EREKCGSYLEKD----------- 1529

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELES--EFDNFEDW 658
                                                  D LKVY  +LE+   F+   D+
Sbjct: 1530 -------------------------------------FDTLKVYDTQLENVEAFEGLSDF 1552

Query: 659  LHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIP 718
             +TF L RGKT ++    TE+  ++G FKG   +Y  PLPED +           F  + 
Sbjct: 1553 CNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLPEDPA----IPMPPRQFHQLA 1602

Query: 719  SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
            +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  + D++NYI   L PVFGK F
Sbjct: 1603 AQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMF 1662

Query: 779  DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNI 838
            ++  + P+E  L + +YD+DL+  D+ IGET +DLENR  SK  A CG+ QTY   G N 
Sbjct: 1663 ELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQ 1722

Query: 839  WRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIED---ENGQRKPTDEH 895
            WRD ++PSQ+L   C+  +V  P +    RV   ++ ++   EIE     N    P +E 
Sbjct: 1723 WRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS-IEEIEAGRIPNPHLGPVEER 1780

Query: 896  VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPL 955
            +AL  L+           LVPEHVE+RPL +P +P IEQG+L++WVD+FP  +  PG P 
Sbjct: 1781 LALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPF 1832

Query: 956  DISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHS 1015
            +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V+GW+ G +E KQ TDVHY S
Sbjct: 1833 NITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRS 1891

Query: 1016 LTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADD 1075
            L GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE KIPAR+  QIWD D FS DD
Sbjct: 1892 LGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDD 1951

Query: 1076 FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIFKQKRVKGWWPLLARNENDEF 1134
            FLG+++LDLNR P+ AKTAK+C+++           VS+F+QK VKGWWP +A  E ++ 
Sbjct: 1952 FLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVA-EEGEKK 2010

Query: 1135 ELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLI 1191
             L GK+E  L ++   E E+ P G  R+EP+    LE P RPDT+F+WF +P K++K+++
Sbjct: 2011 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2070

Query: 1192 CTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLL 1228
              R++W II  ++  + LL L +F+Y+ P Y   KL+
Sbjct: 2071 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2107



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 62/162 (38%), Positives = 92/162 (56%), Gaps = 9/162 (5%)

Query: 18  EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 77
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L+  +    +   
Sbjct: 745 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAA 799

Query: 78  LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 136
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 800 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 859

Query: 137 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 178
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 860 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 898



 Score = 33.9 bits (76), Expect = 0.98
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 226 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 262
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 439 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 475



 Score = 30.8 bits (68), Expect = 8.3
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 747 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 805
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 448 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 505

Query: 806 IGETKIDL 813
           +  T + +
Sbjct: 506 VATTYLSM 513


>gi|195976754 dysferlin isoform 9 [Homo sapiens]
          Length = 2066

 Score =  712 bits (1839), Expect = 0.0
 Identities = 406/1057 (38%), Positives = 583/1057 (55%), Gaps = 149/1057 (14%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1126 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1185

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1186 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1238

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 360
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1239 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1295

Query: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1296 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1352

Query: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1353 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1412

Query: 481  RFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKK 540
             F+  P    +PS     + V  + P                 + ++ +D          
Sbjct: 1413 SFLCDPYSAESPSPQGGPDDVSLLSPG---------------EDVLIDID---------- 1447

Query: 541  KKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKG 600
                  +EP     +E  +DWWSK+FASI        ++E  G  LE+            
Sbjct: 1448 -----DKEPLIPIQEEEFIDWWSKFFASIG-------EREKCGSYLEKD----------- 1484

Query: 601  SMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELES--EFDNFEDW 658
                                                  D LKVY  +LE+   F+   D+
Sbjct: 1485 -------------------------------------FDTLKVYDTQLENVEAFEGLSDF 1507

Query: 659  LHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIP 718
             +TF L RGKT ++    TE+  ++G FKG   +Y  PLPED +           F  + 
Sbjct: 1508 CNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLPEDPA----IPMPPRQFHQLA 1557

Query: 719  SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
            +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  + D++NYI   L PVFGK F
Sbjct: 1558 AQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMF 1617

Query: 779  DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNI 838
            ++  + P+E  L + +YD+DL+  D+ IGET +DLENR  SK  A CG+ QTY   G N 
Sbjct: 1618 ELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQ 1677

Query: 839  WRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIED---ENGQRKPTDEH 895
            WRD ++PSQ+L   C+  +V  P +    RV   ++ ++   EIE     N    P +E 
Sbjct: 1678 WRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS-IEEIEAGRIPNPHLGPVEER 1735

Query: 896  VALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPL 955
            +AL  L+           LVPEHVE+RPL +P +P IEQG+L++WVD+FP  +  PG P 
Sbjct: 1736 LALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPF 1787

Query: 956  DISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHS 1015
            +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V+GW+ G +E KQ TDVHY S
Sbjct: 1788 NITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRS 1846

Query: 1016 LTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADD 1075
            L GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE KIPAR+  QIWD D FS DD
Sbjct: 1847 LGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDD 1906

Query: 1076 FLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIFKQKRVKGWWPLLARNENDEF 1134
            FLG+++LDLNR P+ AKTAK+C+++           VS+F+QK VKGWWP +A  E ++ 
Sbjct: 1907 FLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVA-EEGEKK 1965

Query: 1135 ELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLI 1191
             L GK+E  L ++   E E+ P G  R+EP+    LE P RPDT+F+WF +P K++K+++
Sbjct: 1966 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2025

Query: 1192 CTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLL 1228
              R++W II  ++  + LL L +F+Y+ P Y   KL+
Sbjct: 2026 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2062



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 62/162 (38%), Positives = 92/162 (56%), Gaps = 9/162 (5%)

Query: 18  EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 77
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L+  +    +   
Sbjct: 700 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAA 754

Query: 78  LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 136
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 755 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 814

Query: 137 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 178
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 815 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 853



 Score = 33.9 bits (76), Expect = 0.98
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 226 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 262
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 408 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 444



 Score = 30.8 bits (68), Expect = 8.3
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 747 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 805
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 417 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 474

Query: 806 IGETKIDL 813
           +  T + +
Sbjct: 475 VATTYLSM 482


>gi|19718759 myoferlin isoform b [Homo sapiens]
          Length = 2048

 Score =  681 bits (1756), Expect = 0.0
 Identities = 390/1039 (37%), Positives = 575/1039 (55%), Gaps = 119/1039 (11%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P VS  + +   + LR ++YQAR+L A D    SDP+A + F+++S+ TE+++ TL PTW
Sbjct: 1114 PIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTW 1173

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ ++FD +E+YGE   +  +PP +++E++D D +GK +F+GR+   P+VK+  E     
Sbjct: 1174 DQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM---- 1229

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK--ADLPPINGPVDVDRGPIMPVPMG 378
               P+L ++ +  G+   GD+L   EL+  G  G     LPP   P       +  VP G
Sbjct: 1230 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAP------NLYMVPQG 1283

Query: 379  IRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLV 438
            IRPV+    +E+L WGLR++K   +A +  P + +EC G+ V+S +I N KK PNF + V
Sbjct: 1284 IRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSV 1343

Query: 439  KWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTG 498
             + +V LP+ EL  PPL I+V+D R FGR  +VG   +  L RF                
Sbjct: 1344 LFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRF---------------- 1387

Query: 499  EVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESM 558
                  +P    + +   +K    S    + D+  E ++ K        E EEE     +
Sbjct: 1388 ----RCDPYAGKEDIVPQLKASLLSAPPCR-DIVIEMEDTKPLLASKLTEKEEE-----I 1437

Query: 559  LDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKK 618
            +DWWSK++AS         + E  G  ++               KG  K +    E +  
Sbjct: 1438 VDWWSKFYASSG-------EHEKCGQYIQ---------------KGYSKLKIYNCELENV 1475

Query: 619  TQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTE 678
             +  G                              +F D   TF L RGK+ ++ED S  
Sbjct: 1476 AEFEG----------------------------LTDFSD---TFKLYRGKSDENEDPS-- 1502

Query: 679  EERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLH 738
               +VG FKGS  +Y  PLP+D S  A        F+ +P + P    VR+Y+VR  +L 
Sbjct: 1503 ---VVGEFKGSFRIY--PLPDDPSVPA----PPRQFRELPDSVPQECTVRIYIVRGLELQ 1553

Query: 739  PADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWD 798
            P D NG  DPYI I LGK  I D+++YI   LNPVFG+ +++    P E  L ++VYD+D
Sbjct: 1554 PQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYD 1613

Query: 799  LVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKV 858
                D+ +GET IDLENRF S+  + CGI + Y   G N WRD ++P+Q+L  + +    
Sbjct: 1614 TFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGF 1673

Query: 859  DGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPE 917
              P     G R++   R ++      DE    K   +H+     R    I R    LVPE
Sbjct: 1674 PQPILSEDGSRIRYGGRDYS-----LDEFEANKILHQHLGAPEERLALHILRTQ-GLVPE 1727

Query: 918  HVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEV 977
            HVETR L +  +P I QG+L++WVD+FP  +  PG P +I+PRK KKY LRVIIWNT +V
Sbjct: 1728 HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV 1787

Query: 978  VLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEE 1037
            +L D+   TGE+ SDI+V+GW+ G +E+KQ TDVHY SL GEGNFNWR++FPFDYL AE+
Sbjct: 1788 IL-DEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQ 1846

Query: 1038 KIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQC 1097
              +++KKE  +S D+TE++IP RL +QIWD D FS DD+LG +ELDL      AK+ ++C
Sbjct: 1847 LCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKC 1906

Query: 1098 TMEM-----ATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEA 1152
             ++M     A   +     S+F+QK +KGWWP  A  +     + GKVE  L +L  +EA
Sbjct: 1907 RLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARV-MAGKVEMTLEILNEKEA 1965

Query: 1153 EKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGL 1209
            ++ P G  R+EP+    L+ PNRP+T+F+WF NP K++K+++  R+KW+II ++  L+ L
Sbjct: 1966 DERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILL 2025

Query: 1210 LMLGLFLYSLPGYMVKKLL 1228
            L + + LYSLP Y+  K++
Sbjct: 2026 LFVAVLLYSLPNYLSMKIV 2044



 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 53/145 (36%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 35  QGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADE 94
           +G ++ T LD +  K   R L  + + A  +R++     V+  L   +++L KL  L +E
Sbjct: 697 EGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEAT--DVKSTLAEIEDWLDKLMQLTEE 754

Query: 95  PQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIV-EEETGKDCAKVKTLFLKLPGKRGFG 153
           PQ+S+PDI IWM+   KR+AYAR+P+  +L+S   E  +GK C K +T+FLK P ++  G
Sbjct: 755 PQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNG 814

Query: 154 SAGWTVQAKVELYLWLGLSKQRKEF 178
                V  ++ + +WLGLS   K+F
Sbjct: 815 P---KVPVELRVNIWLGLSAVEKKF 836



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 8/78 (10%)

Query: 228 ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 287
           AD   L DPF  V F  +  CT ++ +   P W+Q++   NL++     +       I +
Sbjct: 389 ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV---NLQI-----KFPSVCEKIKL 440

Query: 288 EIYDQDSMGKADFMGRTF 305
            IYD D + K D +G T+
Sbjct: 441 TIYDWDRLTKNDVVGTTY 458



 Score = 37.7 bits (86), Expect = 0.068
 Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 3/75 (4%)

Query: 740 ADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPME-SMLTVAVYDWD 798
           AD     DP++ +      +    N I K  NP + +  +++  FP     + + +YDWD
Sbjct: 389 ADKKNLVDPFVEVSFAGKKVCT--NIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWD 446

Query: 799 LVGTDDLIGETKIDL 813
            +  +D++G T + L
Sbjct: 447 RLTKNDVVGTTYLHL 461



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 719 SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
           SN P +  +RV V+    L   +I      ++  +  +T I+   N    +L   F  + 
Sbjct: 193 SNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDEL---FFYNV 249

Query: 779 DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDL 813
           ++  S  M+ ++++ VY+   +  D L+GE KID+
Sbjct: 250 NMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV 284


>gi|7305053 myoferlin isoform a [Homo sapiens]
          Length = 2061

 Score =  681 bits (1756), Expect = 0.0
 Identities = 390/1039 (37%), Positives = 575/1039 (55%), Gaps = 119/1039 (11%)

Query: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260
            P VS  + +   + LR ++YQAR+L A D    SDP+A + F+++S+ TE+++ TL PTW
Sbjct: 1127 PIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTW 1186

Query: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320
            DQ ++FD +E+YGE   +  +PP +++E++D D +GK +F+GR+   P+VK+  E     
Sbjct: 1187 DQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM---- 1242

Query: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK--ADLPPINGPVDVDRGPIMPVPMG 378
               P+L ++ +  G+   GD+L   EL+  G  G     LPP   P       +  VP G
Sbjct: 1243 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAP------NLYMVPQG 1296

Query: 379  IRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLV 438
            IRPV+    +E+L WGLR++K   +A +  P + +EC G+ V+S +I N KK PNF + V
Sbjct: 1297 IRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSV 1356

Query: 439  KWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTG 498
             + +V LP+ EL  PPL I+V+D R FGR  +VG   +  L RF                
Sbjct: 1357 LFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRF---------------- 1400

Query: 499  EVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESM 558
                  +P    + +   +K    S    + D+  E ++ K        E EEE     +
Sbjct: 1401 ----RCDPYAGKEDIVPQLKASLLSAPPCR-DIVIEMEDTKPLLASKLTEKEEE-----I 1450

Query: 559  LDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKK 618
            +DWWSK++AS         + E  G  ++               KG  K +    E +  
Sbjct: 1451 VDWWSKFYASSG-------EHEKCGQYIQ---------------KGYSKLKIYNCELENV 1488

Query: 619  TQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTE 678
             +  G                              +F D   TF L RGK+ ++ED S  
Sbjct: 1489 AEFEG----------------------------LTDFSD---TFKLYRGKSDENEDPS-- 1515

Query: 679  EERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLH 738
               +VG FKGS  +Y  PLP+D S  A        F+ +P + P    VR+Y+VR  +L 
Sbjct: 1516 ---VVGEFKGSFRIY--PLPDDPSVPA----PPRQFRELPDSVPQECTVRIYIVRGLELQ 1566

Query: 739  PADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWD 798
            P D NG  DPYI I LGK  I D+++YI   LNPVFG+ +++    P E  L ++VYD+D
Sbjct: 1567 PQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYD 1626

Query: 799  LVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKV 858
                D+ +GET IDLENRF S+  + CGI + Y   G N WRD ++P+Q+L  + +    
Sbjct: 1627 TFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGF 1686

Query: 859  DGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPE 917
              P     G R++   R ++      DE    K   +H+     R    I R    LVPE
Sbjct: 1687 PQPILSEDGSRIRYGGRDYS-----LDEFEANKILHQHLGAPEERLALHILRTQ-GLVPE 1740

Query: 918  HVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEV 977
            HVETR L +  +P I QG+L++WVD+FP  +  PG P +I+PRK KKY LRVIIWNT +V
Sbjct: 1741 HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV 1800

Query: 978  VLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEE 1037
            +L D+   TGE+ SDI+V+GW+ G +E+KQ TDVHY SL GEGNFNWR++FPFDYL AE+
Sbjct: 1801 IL-DEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQ 1859

Query: 1038 KIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQC 1097
              +++KKE  +S D+TE++IP RL +QIWD D FS DD+LG +ELDL      AK+ ++C
Sbjct: 1860 LCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKC 1919

Query: 1098 TMEM-----ATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEA 1152
             ++M     A   +     S+F+QK +KGWWP  A  +     + GKVE  L +L  +EA
Sbjct: 1920 RLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARV-MAGKVEMTLEILNEKEA 1978

Query: 1153 EKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGL 1209
            ++ P G  R+EP+    L+ PNRP+T+F+WF NP K++K+++  R+KW+II ++  L+ L
Sbjct: 1979 DERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILL 2038

Query: 1210 LMLGLFLYSLPGYMVKKLL 1228
            L + + LYSLP Y+  K++
Sbjct: 2039 LFVAVLLYSLPNYLSMKIV 2057



 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 53/145 (36%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 35  QGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADE 94
           +G ++ T LD +  K   R L  + + A  +R++     V+  L   +++L KL  L +E
Sbjct: 710 EGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEAT--DVKSTLAEIEDWLDKLMQLTEE 767

Query: 95  PQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIV-EEETGKDCAKVKTLFLKLPGKRGFG 153
           PQ+S+PDI IWM+   KR+AYAR+P+  +L+S   E  +GK C K +T+FLK P ++  G
Sbjct: 768 PQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNG 827

Query: 154 SAGWTVQAKVELYLWLGLSKQRKEF 178
                V  ++ + +WLGLS   K+F
Sbjct: 828 P---KVPVELRVNIWLGLSAVEKKF 849



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 8/78 (10%)

Query: 228 ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 287
           AD   L DPF  V F  +  CT ++ +   P W+Q++   NL++     +       I +
Sbjct: 389 ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV---NLQI-----KFPSVCEKIKL 440

Query: 288 EIYDQDSMGKADFMGRTF 305
            IYD D + K D +G T+
Sbjct: 441 TIYDWDRLTKNDVVGTTY 458



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 25/97 (25%), Positives = 46/97 (47%), Gaps = 8/97 (8%)

Query: 740 ADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPME-SMLTVAVYDWD 798
           AD     DP++ +      +    N I K  NP + +  +++  FP     + + +YDWD
Sbjct: 389 ADKKNLVDPFVEVSFAGKKVCT--NIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWD 446

Query: 799 LVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 835
            +  +D++G T + L     SK  A+ G  + +S+ G
Sbjct: 447 RLTKNDVVGTTYLHL-----SKIAASGGEVEDFSSSG 478



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 719 SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778
           SN P +  +RV V+    L   +I      ++  +  +T I+   N    +L   F  + 
Sbjct: 193 SNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDEL---FFYNV 249

Query: 779 DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDL 813
           ++  S  M+ ++++ VY+   +  D L+GE KID+
Sbjct: 250 NMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV 284


>gi|116642865 fer-1-like 5 isoform 1 [Homo sapiens]
          Length = 802

 Score =  421 bits (1083), Expect = e-117
 Identities = 242/602 (40%), Positives = 350/602 (58%), Gaps = 45/602 (7%)

Query: 641  LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 698
            LKVY  ELE+   F   +D+  TF L + +   D         +VG FKG   +Y  P P
Sbjct: 156  LKVYECELEAVPAFQGLQDFCQTFKLYQEQPKLDSP-------VVGEFKGLFRIY--PFP 206

Query: 699  EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 758
            E+   EA       +      + P   LVRVY+VRA +L P D NG  DPY+ ++LGKT+
Sbjct: 207  ENP--EAPKPPLQFLVWPEREDFPQPCLVRVYMVRAINLQPQDYNGLCDPYVILKLGKTE 264

Query: 759  IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 818
            + +++ Y    L+P+FG  F++  + P+E  L + +YD+DL   DD IG T IDLENR  
Sbjct: 265  LGNRDMYQPNTLDPIFGMMFELTCNIPLEKDLEIQLYDFDLFSPDDKIGTTVIDLENRLL 324

Query: 819  SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 878
            S   A CG++++Y   G   WRD M PS +L R  K   +  P F P       + VF  
Sbjct: 325  SGFGAHCGLSKSYCQSGPFRWRDQMPPSYLLERYAKRKGLPPPLFSPE-----EDAVFYN 379

Query: 879  PSEIEDENGQRK--------PTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKP 930
              + + ++ + K        P  E +AL  L H +        LVPEHVETR L +  +P
Sbjct: 380  GKKFKLQSFEPKTPTVHGLGPKKERLALYLL-HTQG-------LVPEHVETRTLYSHSQP 431

Query: 931  GIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKS 990
            GI+QG++++WVD+FP  +  PG  ++I+PRKPK+YELR IIW T  V L DD+  + EK+
Sbjct: 432  GIDQGKVQMWVDIFPKKLGPPGPQVNINPRKPKRYELRCIIWKTANVDLVDDNL-SREKT 490

Query: 991  SDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSW 1050
            SDI+++GWL G ++D Q TD+HYHSLTGE +FNWR++F  DYLAAE   V S+K+ ++S 
Sbjct: 491  SDIYIKGWLYGLEKDMQKTDIHYHSLTGEADFNWRFIFTMDYLAAERTCVQSQKDYIWSL 550

Query: 1051 DETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPL 1110
            D T  K PARL +Q+WD D FS DDFLG +ELDL+  P  A+ AKQC++ M   +   P 
Sbjct: 551  DATSMKFPARLIIQVWDNDIFSPDDFLGVLELDLSDMPLPARHAKQCSIRMMDADPKWPY 610

Query: 1111 ------VSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEP 1164
                   S+FK+K V GWWP     +  ++ L+GKV+  L +L+ +EA   P G  ++EP
Sbjct: 611  FIQYKHFSLFKKKTVTGWWPCQVL-DGGKWRLSGKVKMSLEILSEKEALIKPAGRGQSEP 669

Query: 1165 D---PLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGLLMLGLFLYSLPG 1221
            +    L  P R +T+F W  +P+++  Y+   RY++ +I  ++  +  LML  F+YS P 
Sbjct: 670  NQYPTLHPPLRTNTSFTWLRSPVQNFCYIFWKRYRFKLIAFMVISIIALMLFNFIYSAPH 729

Query: 1222 YM 1223
            Y+
Sbjct: 730  YL 731



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 60/254 (23%), Positives = 101/254 (39%), Gaps = 41/254 (16%)

Query: 403 LAQVDRPRVDIECAGKGVQSSLIHNYKKNPNF--NTLVKWFEVDLPENELLHPPLNIRVV 460
           + +   P++ +E   + +++  I +++ NPNF  +  V    V +P  E    PL ++VV
Sbjct: 1   MKKASSPQLLVEFGEESLRTEPIRDFQTNPNFPESESVLVLTVLMPTEEAYALPLVVKVV 60

Query: 461 DCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLD 520
           D  AFG+ T+ G   +  L+ +   P       W         M P++P           
Sbjct: 61  DNWAFGQQTVTGQANIDFLQPYFCDP-------WAQD-----YMHPKLP----------- 97

Query: 521 ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 580
            T       D       K   K   AE+  E E     +DWWSK F + D  K  L+ + 
Sbjct: 98  -TLSEKKHQDFLGYLYRKFWFKSSKAEDEYEHE-----VDWWSKLFWATDEHK-SLKYKY 150

Query: 581 PSGIDLEEKE-EVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQG-------SEAPE 632
                L+  E E++     +G     +  +  +E+ K  +   G  +G        E PE
Sbjct: 151 KDYHTLKVYECELEAVPAFQGLQDFCQTFKLYQEQPKLDSPVVGEFKGLFRIYPFPENPE 210

Query: 633 KKKPKIDELKVYPK 646
             KP +  L V+P+
Sbjct: 211 APKPPLQFL-VWPE 223


>gi|164607133 fer-1-like 5 isoform 2 [Homo sapiens]
          Length = 2093

 Score =  414 bits (1063), Expect = e-115
 Identities = 242/611 (39%), Positives = 350/611 (57%), Gaps = 54/611 (8%)

Query: 641  LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 698
            LKVY  ELE+   F   +D+  TF L + +   D         +VG FKG   +Y  P P
Sbjct: 1438 LKVYECELEAVPAFQGLQDFCQTFKLYQEQPKLDSP-------VVGEFKGLFRIY--PFP 1488

Query: 699  EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 758
            E+   EA       +      + P   LVRVY+VRA +L P D NG  DPY+ ++LGKT+
Sbjct: 1489 ENP--EAPKPPLQFLVWPEREDFPQPCLVRVYMVRAINLQPQDYNGLCDPYVILKLGKTE 1546

Query: 759  IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 818
            + +++ Y    L+P+FG  F++  + P+E  L + +YD+DL   DD IG T IDLENR  
Sbjct: 1547 LGNRDMYQPNTLDPIFGMMFELTCNIPLEKDLEIQLYDFDLFSPDDKIGTTVIDLENRLL 1606

Query: 819  SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 878
            S   A CG++++Y   G   WRD M PS +L R  K   +  P F P       + VF  
Sbjct: 1607 SGFGAHCGLSKSYCQSGPFRWRDQMPPSYLLERYAKRKGLPPPLFSPE-----EDAVFYN 1661

Query: 879  PSEIEDENGQRK--------PTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKP 930
              + + ++ + K        P  E +AL  L H +        LVPEHVETR L +  +P
Sbjct: 1662 GKKFKLQSFEPKTPTVHGLGPKKERLALYLL-HTQG-------LVPEHVETRTLYSHSQP 1713

Query: 931  GIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKK---------YELRVIIWNTDEVVLED 981
            GI+QG++++WVD+FP  +  PG  ++I+PRKPK+         YELR IIW T  V L D
Sbjct: 1714 GIDQGKVQMWVDIFPKKLGPPGPQVNINPRKPKRKASEHSGHRYELRCIIWKTANVDLVD 1773

Query: 982  DDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVI 1041
            D+  + EK+SDI+++GWL G ++D Q TD+HYHSLTGE +FNWR++F  DYLAAE   V 
Sbjct: 1774 DNL-SREKTSDIYIKGWLYGLEKDMQKTDIHYHSLTGEADFNWRFIFTMDYLAAERTCVQ 1832

Query: 1042 SKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEM 1101
            S+K+ ++S D T  K PARL +Q+WD D FS DDFLG +ELDL+  P  A+ AKQC++ M
Sbjct: 1833 SQKDYIWSLDATSMKFPARLIIQVWDNDIFSPDDFLGVLELDLSDMPLPARHAKQCSIRM 1892

Query: 1102 ATGEVDVPL------VSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKN 1155
               +   P        S+FK+K V GWWP     +  ++ L+GKV+  L +L+ +EA   
Sbjct: 1893 MDADPKWPYFIQYKHFSLFKKKTVTGWWPCQVL-DGGKWRLSGKVKMSLEILSEKEALIK 1951

Query: 1156 PVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGLLML 1212
            P G  ++EP+    L  P R +T+F W  +P+++  Y+   RY++ +I  ++  +  LML
Sbjct: 1952 PAGRGQSEPNQYPTLHPPLRTNTSFTWLRSPVQNFCYIFWKRYRFKLIAFMVISIIALML 2011

Query: 1213 GLFLYSLPGYM 1223
              F+YS P Y+
Sbjct: 2012 FNFIYSAPHYL 2022



 Score =  148 bits (374), Expect = 3e-35
 Identities = 137/507 (27%), Positives = 227/507 (44%), Gaps = 60/507 (11%)

Query: 153  GSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQA 212
            G   W VQA ++L    G  +  K +  GL   F++ +  Q       P +   + K   
Sbjct: 1046 GRLSW-VQA-MDLKYHAGKEEDSKTWPWGLDRQFRDPQR-QDTRPPNLPFIYCTFNKPHY 1102

Query: 213  FQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELY 272
            +QL  ++YQAR+L +        PF RV F+N SQCT+ L  +  PTW Q L+F +L LY
Sbjct: 1103 YQLFCYIYQARNLVSNQILTFQGPFIRVVFLNHSQCTQTLRSSAGPTWAQTLIFQHLLLY 1162

Query: 273  GEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLV--KMADEAYCPPRFPPQLEYYQ 330
                + ++ PP++V+E++ +D  GK    GR+   P+V   + D    P R+ P ++   
Sbjct: 1163 ENPQDTKESPPLVVLELWQRDFWGKESLWGRSVWPPMVWLDLQDRILPPMRWHPLVKEL- 1221

Query: 331  IYRGNATAGDLLAAFEL-LQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVE 389
                    G++LA+ EL LQ    G+  LP ++ P    +     +P  I+P + +  +E
Sbjct: 1222 ----GKEEGEILASCELILQTEKLGEKQLPILSVPW---KNGAYTLPKSIQPTIKRMAIE 1274

Query: 390  VLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNF--NTLVKWFEVDLPE 447
            +L WGLR++K+ +      P++ +E   + +++  I +++ NPNF  +  V    V +P 
Sbjct: 1275 ILAWGLRNMKKAS-----SPQLLVEFGEESLRTEPIRDFQTNPNFPESESVLVLTVLMPT 1329

Query: 448  NELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTGEVVVTMEPE 507
             E    PL ++VVD  AFG+ T+ G   +  L+ +   P       W         M P+
Sbjct: 1330 EEAYALPLVVKVVDNWAFGQQTVTGQANIDFLQPYFCDP-------WAQD-----YMHPK 1377

Query: 508  VPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFA 567
            +P            T       D       K   K   AE+  E E     +DWWSK F 
Sbjct: 1378 LP------------TLSEKKHQDFLGYLYRKFWFKSSKAEDEYEHE-----VDWWSKLFW 1420

Query: 568  SIDTMKEQLRQQEPSGIDLEEKE-EVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQ 626
            + D  K  L+ +      L+  E E++     +G     +  +  +E+ K  +   G  +
Sbjct: 1421 ATDEHK-SLKYKYKDYHTLKVYECELEAVPAFQGLQDFCQTFKLYQEQPKLDSPVVGEFK 1479

Query: 627  G-------SEAPEKKKPKIDELKVYPK 646
            G        E PE  KP +  L V+P+
Sbjct: 1480 GLFRIYPFPENPEAPKPPLQFL-VWPE 1505



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 41/131 (31%), Positives = 73/131 (55%), Gaps = 11/131 (8%)

Query: 41  TRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIP 100
           T LDR+R +     L+ + Q+A+  +        +D +   +++L +L  +  EPQ  +P
Sbjct: 640 TSLDRKRWQLRSLLLQELAQKAKQAKP-------KDMVATAEDWLYRLNTVLPEPQMGLP 692

Query: 101 DIFIWMMSNNKRVAYARVPSKDLLFSIVEE-ETGKDCAKVKTLFLKLPGKRGFGSAGWTV 159
           D+ IW+++  +RVAYA+VP+  +LFS      +G+ C K++TLFL+ P   G       +
Sbjct: 693 DVMIWLVAKEQRVAYAQVPAHSVLFSPAGALHSGRLCGKIQTLFLQYPEGEGQKD---VL 749

Query: 160 QAKVELYLWLG 170
            A + + +WLG
Sbjct: 750 PAHLRVCMWLG 760


>gi|4759026 RAS protein activator like 1 [Homo sapiens]
          Length = 804

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 37/94 (39%), Positives = 51/94 (54%), Gaps = 9/94 (9%)

Query: 215 LRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGE 274
           LR H+  AR L   D SG SDPFARVF+ +QS  T  + +T  P WD++L         E
Sbjct: 135 LRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVL---------E 185

Query: 275 AHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKP 308
             E+   P  + +E++D D +GK DF+G     P
Sbjct: 186 LREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSP 219



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 25/81 (30%), Positives = 44/81 (54%), Gaps = 2/81 (2%)

Query: 727 VRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPM 786
           +R +V+ A DL P DI+G +DP+  +  G   +  + + I K   P + +  ++      
Sbjct: 135 LRCHVLHARDLAPRDISGTSDPFARVFWGSQSL--ETSTIKKTRFPHWDEVLELREMPGA 192

Query: 787 ESMLTVAVYDWDLVGTDDLIG 807
            S L V ++DWD+VG +D +G
Sbjct: 193 PSPLRVELWDWDMVGKNDFLG 213



 Score = 39.7 bits (91), Expect = 0.018
 Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 2/88 (2%)

Query: 727 VRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPM 786
           + V VV    L   D++G +DPY  +++   ++  +   + + L P +G+ + +      
Sbjct: 7   LNVRVVEGRALPAKDVSGSSDPYCLVKVDD-EVVARTATVWRSLGPFWGEEYTVHLPLDF 65

Query: 787 ESMLTVAVYDWDLVGTDDLIGETKIDLE 814
              L   V D D VG DD+IG+  +  E
Sbjct: 66  HQ-LAFYVLDEDTVGHDDIIGKISLSRE 92


>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 2 [Homo sapiens]
          Length = 731

 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 727 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 785
           +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 63  LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 119

Query: 786 MESMLTVAVYDWDLVGTDDLIGETKIDLE 814
               L V  +DWDLV  +D +G+  ID++
Sbjct: 120 AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 148



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 206 VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 265
           V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 54  VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 113

Query: 266 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 303
           F+  E   EA         + +E +D D + + DF+G+
Sbjct: 114 FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 142



 Score = 31.6 bits (70), Expect = 4.9
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1032 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1086
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 90   YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 149


>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 1 [Homo sapiens]
          Length = 757

 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 727 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 785
           +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 191

Query: 786 MESMLTVAVYDWDLVGTDDLIGETKIDLE 814
               L V  +DWDLV  +D +G+  ID++
Sbjct: 192 AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 220



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 206 VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 265
           V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 126 VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185

Query: 266 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 303
           F+  E   EA         + +E +D D + + DF+G+
Sbjct: 186 FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 214



 Score = 31.6 bits (70), Expect = 4.9
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1032 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1086
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 162  YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 221


>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 1 [Homo sapiens]
          Length = 731

 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 727 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 785
           +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 63  LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 119

Query: 786 MESMLTVAVYDWDLVGTDDLIGETKIDLE 814
               L V  +DWDLV  +D +G+  ID++
Sbjct: 120 AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 148



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 206 VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 265
           V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 54  VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 113

Query: 266 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 303
           F+  E   EA         + +E +D D + + DF+G+
Sbjct: 114 FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 142



 Score = 31.6 bits (70), Expect = 4.9
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1032 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1086
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 90   YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 149


>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 2 [Homo sapiens]
          Length = 757

 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 727 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 785
           +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 191

Query: 786 MESMLTVAVYDWDLVGTDDLIGETKIDLE 814
               L V  +DWDLV  +D +G+  ID++
Sbjct: 192 AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 220



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 206 VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 265
           V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 126 VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185

Query: 266 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 303
           F+  E   EA         + +E +D D + + DF+G+
Sbjct: 186 FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 214



 Score = 31.6 bits (70), Expect = 4.9
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1032 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1086
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 162  YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 221


>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
          Length = 757

 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 727 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 785
           +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 191

Query: 786 MESMLTVAVYDWDLVGTDDLIGETKIDLE 814
               L V  +DWDLV  +D +G+  ID++
Sbjct: 192 AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 220



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 206 VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 265
           V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 126 VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185

Query: 266 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 303
           F+  E   EA         + +E +D D + + DF+G+
Sbjct: 186 FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 214



 Score = 31.6 bits (70), Expect = 4.9
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1032 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1086
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 162  YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 221


>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
          Length = 803

 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 727 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 785
           +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 191

Query: 786 MESMLTVAVYDWDLVGTDDLIGETKIDLE 814
               L V  +DWDLV  +D +G+  ID++
Sbjct: 192 AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 220



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 206 VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 265
           V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 126 VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185

Query: 266 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 303
           F+  E   EA         + +E +D D + + DF+G+
Sbjct: 186 FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 214



 Score = 31.6 bits (70), Expect = 4.9
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1032 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1086
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 162  YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 221


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,396,596
Number of Sequences: 37866
Number of extensions: 2590363
Number of successful extensions: 15706
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 454
Number of HSP's that attempted gapping in prelim test: 11200
Number of HSP's gapped (non-prelim): 2977
length of query: 1230
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1116
effective length of database: 13,930,794
effective search space: 15546766104
effective search space used: 15546766104
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.