Search of human proteins with 35493853

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|35493853 otoferlin isoform c [Homo sapiens]
         (1307 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|35493853 otoferlin isoform c [Homo sapiens]                       2670   0.0  
gi|34740331 otoferlin isoform a [Homo sapiens]                       2577   0.0  
gi|35493868 otoferlin isoform b [Homo sapiens]                       2503   0.0  
gi|35493860 otoferlin isoform d [Homo sapiens]                       2470   0.0  
gi|119120884 fer-1-like 6 [Homo sapiens]                             1261   0.0  
gi|195976779 dysferlin isoform 1 [Homo sapiens]                       723   0.0  
gi|195976773 dysferlin isoform 5 [Homo sapiens]                       723   0.0  
gi|195976769 dysferlin isoform 6 [Homo sapiens]                       723   0.0  
gi|195976764 dysferlin isoform 14 [Homo sapiens]                      723   0.0  
gi|195976758 dysferlin isoform 11 [Homo sapiens]                      723   0.0  
gi|195976756 dysferlin isoform 10 [Homo sapiens]                      723   0.0  
gi|195976821 dysferlin isoform 2 [Homo sapiens]                       712   0.0  
gi|4503431 dysferlin isoform 8 [Homo sapiens]                         712   0.0  
gi|195976777 dysferlin isoform 3 [Homo sapiens]                       712   0.0  
gi|195976775 dysferlin isoform 4 [Homo sapiens]                       712   0.0  
gi|195976766 dysferlin isoform 7 [Homo sapiens]                       712   0.0  
gi|195976762 dysferlin isoform 13 [Homo sapiens]                      712   0.0  
gi|195976760 dysferlin isoform 12 [Homo sapiens]                      712   0.0  
gi|195976754 dysferlin isoform 9 [Homo sapiens]                       712   0.0  
gi|19718759 myoferlin isoform b [Homo sapiens]                        684   0.0  
gi|7305053 myoferlin isoform a [Homo sapiens]                         684   0.0  
gi|116642865 fer-1-like 5 isoform 1 [Homo sapiens]                    429   e-119
gi|164607133 fer-1-like 5 isoform 2 [Homo sapiens]                    421   e-117
gi|4759026 RAS protein activator like 1 [Homo sapiens]                 66   2e-10
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva...    55   6e-07
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva...    55   6e-07
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva...    55   6e-07
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva...    55   6e-07
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]      55   6e-07
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]      55   6e-07

>gi|35493853 otoferlin isoform c [Homo sapiens]
          Length = 1307

 Score = 2670 bits (6921), Expect = 0.0
 Identities = 1307/1307 (100%), Positives = 1307/1307 (100%)

Query: 1    MMTDTQDGPSESSQIMRSLTPLINREEAFGEAGEAGLWPSITHTPDSQEEGLNDIQEMIK 60
            MMTDTQDGPSESSQIMRSLTPLINREEAFGEAGEAGLWPSITHTPDSQEEGLNDIQEMIK
Sbjct: 1    MMTDTQDGPSESSQIMRSLTPLINREEAFGEAGEAGLWPSITHTPDSQEEGLNDIQEMIK 60

Query: 61   TEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQAR 120
            TEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQAR
Sbjct: 61   TEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQAR 120

Query: 121  MLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDL 180
            MLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDL
Sbjct: 121  MLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDL 180

Query: 181  LFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLP 240
            LFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLP
Sbjct: 181  LFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLP 240

Query: 241  CGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFI 300
            CGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFI
Sbjct: 241  CGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFI 300

Query: 301  NQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 360
            NQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR
Sbjct: 301  NQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 360

Query: 361  TFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPING 420
            TFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPING
Sbjct: 361  TFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPING 420

Query: 421  PVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSS 480
            PVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSS
Sbjct: 421  PVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSS 480

Query: 481  LIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFI 540
            LIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFI
Sbjct: 481  LIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFI 540

Query: 541  YRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATS 600
            YRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATS
Sbjct: 541  YRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATS 600

Query: 601  EAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSG 660
            EAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSG
Sbjct: 601  EAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSG 660

Query: 661  IDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKV 720
            IDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKV
Sbjct: 661  IDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKV 720

Query: 721  YPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSR 780
            YPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSR
Sbjct: 721  YPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSR 780

Query: 781  EAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKE 840
            EAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKE
Sbjct: 781  EAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKE 840

Query: 841  NYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRA 900
            NYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRA
Sbjct: 841  NYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRA 900

Query: 901  TCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIE 960
            TCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIE
Sbjct: 901  TCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIE 960

Query: 961  DENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDM 1020
            DENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDM
Sbjct: 961  DENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDM 1020

Query: 1021 FPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQ 1080
            FPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQ
Sbjct: 1021 FPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQ 1080

Query: 1081 EDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTL 1140
            EDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTL
Sbjct: 1081 EDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTL 1140

Query: 1141 QIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWW 1200
            QIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWW
Sbjct: 1141 QIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWW 1200

Query: 1201 PLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNP 1260
            PLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNP
Sbjct: 1201 PLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNP 1260

Query: 1261 LKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA 1307
            LKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA
Sbjct: 1261 LKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA 1307


>gi|34740331 otoferlin isoform a [Homo sapiens]
          Length = 1997

 Score = 2577 bits (6680), Expect = 0.0
 Identities = 1261/1265 (99%), Positives = 1261/1265 (99%)

Query: 43   HTPDSQEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDR 102
            H  D  EEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDR
Sbjct: 733  HIADKLEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDR 792

Query: 103  ERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIW 162
            ERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIW
Sbjct: 793  ERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIW 852

Query: 163  MMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVEL 222
            MMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVEL
Sbjct: 853  MMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVEL 912

Query: 223  YLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSL 282
            YLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSL
Sbjct: 913  YLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSL 972

Query: 283  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPII 342
            FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPII
Sbjct: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPII 1032

Query: 343  VIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAF 402
            VIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAF
Sbjct: 1033 VIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAF 1092

Query: 403  ELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQ 462
            ELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQ
Sbjct: 1093 ELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQ 1152

Query: 463  VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAF 522
            VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAF
Sbjct: 1153 VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAF 1212

Query: 523  GRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTME 582
            GRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTME
Sbjct: 1213 GRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTME 1272

Query: 583  PEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKY 642
            PEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKY
Sbjct: 1273 PEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKY 1332

Query: 643  FASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSG 702
            FASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSG
Sbjct: 1333 FASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSG 1392

Query: 703  QGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGR 762
            QGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGR
Sbjct: 1393 QGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGR 1452

Query: 763  FKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGK 822
            FKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGK
Sbjct: 1453 FKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGK 1512

Query: 823  ADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDL 882
            ADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDL
Sbjct: 1513 ADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDL 1572

Query: 883  IGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGP 942
            IGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGP
Sbjct: 1573 IGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGP 1632

Query: 943  PGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLL 1002
            PGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLL
Sbjct: 1633 PGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLL 1692

Query: 1003 NPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFF 1062
            NPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFF
Sbjct: 1693 NPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFF 1752

Query: 1063 TGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKE 1122
            TGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKE
Sbjct: 1753 TGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKE 1812

Query: 1123 SMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGE 1182
            SMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGE
Sbjct: 1813 SMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGE 1872

Query: 1183 VDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD 1242
            VDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD
Sbjct: 1873 VDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD 1932

Query: 1243 PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVK 1302
            PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVK
Sbjct: 1933 PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVK 1992

Query: 1303 KILGA 1307
            KILGA
Sbjct: 1993 KILGA 1997



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 16/51 (31%), Positives = 26/51 (50%)

Query: 276 MYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNL 326
           M   +  F  ++  L DP+ +VFF  Q   T V   +  P W++ +VF +L
Sbjct: 437 MANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487


>gi|35493868 otoferlin isoform b [Homo sapiens]
          Length = 1230

 Score = 2503 bits (6488), Expect = 0.0
 Identities = 1230/1250 (98%), Positives = 1230/1250 (98%), Gaps = 20/1250 (1%)

Query: 58   MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 117
            MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ
Sbjct: 1    MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 60

Query: 118  QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 177
            QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS
Sbjct: 61   QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 120

Query: 178  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 237
            KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC
Sbjct: 121  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 180

Query: 238  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 297
            GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV
Sbjct: 181  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 240

Query: 298  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 357
            FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF
Sbjct: 241  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 300

Query: 358  MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 417
            MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP
Sbjct: 301  MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 360

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
            INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV
Sbjct: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR
Sbjct: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 597
            RFIYRPPDRSAPSWNTT                    GEVVVTMEPEVPIKKLETMVKLD
Sbjct: 481  RFIYRPPDRSAPSWNTT--------------------GEVVVTMEPEVPIKKLETMVKLD 520

Query: 598  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 657
            ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE
Sbjct: 521  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 580

Query: 658  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 717
            PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE
Sbjct: 581  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 640

Query: 718  LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED 777
            LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED
Sbjct: 641  LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED 700

Query: 778  VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR 837
            VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR
Sbjct: 701  VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR 760

Query: 838  DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK 897
            DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK
Sbjct: 761  DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK 820

Query: 898  HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS 957
            HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS
Sbjct: 821  HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS 880

Query: 958  EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW 1017
            EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW
Sbjct: 881  EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW 940

Query: 1018 VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK 1077
            VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK
Sbjct: 941  VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK 1000

Query: 1078 GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR 1137
            GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR
Sbjct: 1001 GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR 1060

Query: 1138 LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK 1197
            LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK
Sbjct: 1061 LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK 1120

Query: 1198 GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWF 1257
            GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWF
Sbjct: 1121 GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWF 1180

Query: 1258 LNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA 1307
            LNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA
Sbjct: 1181 LNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA 1230


>gi|35493860 otoferlin isoform d [Homo sapiens]
          Length = 1230

 Score = 2470 bits (6401), Expect = 0.0
 Identities = 1209/1250 (96%), Positives = 1222/1250 (97%), Gaps = 20/1250 (1%)

Query: 58   MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 117
            MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ
Sbjct: 1    MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 60

Query: 118  QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 177
            QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS
Sbjct: 61   QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 120

Query: 178  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 237
            KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC
Sbjct: 121  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 180

Query: 238  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 297
            GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV
Sbjct: 181  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 240

Query: 298  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 357
            FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF
Sbjct: 241  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 300

Query: 358  MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 417
            MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP
Sbjct: 301  MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 360

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
            INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV
Sbjct: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR
Sbjct: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 597
            RFIYRPPDRSAPSWNTT                    GEVVVTMEPEVPIKKLETMVKLD
Sbjct: 481  RFIYRPPDRSAPSWNTT--------------------GEVVVTMEPEVPIKKLETMVKLD 520

Query: 598  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 657
            ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE
Sbjct: 521  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 580

Query: 658  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 717
            PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE
Sbjct: 581  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 640

Query: 718  LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED 777
            LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED
Sbjct: 641  LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED 700

Query: 778  VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR 837
            VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR
Sbjct: 701  VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR 760

Query: 838  DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK 897
            DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK
Sbjct: 761  DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK 820

Query: 898  HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS 957
            HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS
Sbjct: 821  HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS 880

Query: 958  EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW 1017
            EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW
Sbjct: 881  EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW 940

Query: 1018 VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK 1077
            VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK
Sbjct: 941  VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK 1000

Query: 1078 GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR 1137
            GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR
Sbjct: 1001 GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR 1060

Query: 1138 LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK 1197
            LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK
Sbjct: 1061 LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK 1120

Query: 1198 GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWF 1257
            GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDT+F+WF
Sbjct: 1121 GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWF 1180

Query: 1258 LNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA 1307
            LNPLKS +Y +   Y+WL++K++L LL LL+L LFLYS+PGY+VKK+LGA
Sbjct: 1181 LNPLKSIKYLICTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLLGA 1230


>gi|119120884 fer-1-like 6 [Homo sapiens]
          Length = 1857

 Score = 1261 bits (3263), Expect = 0.0
 Identities = 638/1299 (49%), Positives = 893/1299 (68%), Gaps = 88/1299 (6%)

Query: 46   DSQEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERL 105
            D  EE + +++E+IK  +  PE +++ VL +       F+S A+K     ++T LD++RL
Sbjct: 605  DFLEESIEEVRELIKISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRL 664

Query: 106  KSCMRELENMGQQAR-MLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMM 164
              C +ELE M ++A+ +++ Q K+ +V + +   QNF++K+RFL DEPQH+IPD+FIWM+
Sbjct: 665  TLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVFIWML 724

Query: 165  SNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYL 224
            SNN+RVAYAR+ SKDLL+S V  + GK C K+KT FLK PGKR    AGW+VQAKV++YL
Sbjct: 725  SNNRRVAYARIASKDLLYSPVAGQMGKHCGKIKTHFLKPPGKR---PAGWSVQAKVDVYL 781

Query: 225  WLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFA 284
            WLG  K     L  LP G++   +++G G +  PP +L+Y ++  FQLRAHMYQAR L A
Sbjct: 782  WLGSIKHASAILDNLPVGYEAEMSSKGAGTN-HPPSNLLYQEQHVFQLRAHMYQARGLIA 840

Query: 285  ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 344
            ADS+GLSDPFA+V F++  Q T+++++TL PTW+QML+F++L L+G+  EL + PP++V+
Sbjct: 841  ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900

Query: 345  EIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFEL 404
            E+YD D++GK +++G T A P+VK+AD+ Y PPR    L Y+ I+ GN + GDLLA FEL
Sbjct: 901  ELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPR----LCYHPIFCGNLSGGDLLAVFEL 956

Query: 405  LQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVD 464
            LQ+ P+G   LPP+  P   D   I PVP  IRPVLSKYRVEVLFWG+R++K+V L  VD
Sbjct: 957  LQVPPSGLQGLPPVEPP---DITQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVD 1013

Query: 465  RPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGR 524
            RP+  IEC G+GV+S +I +YK NPNF+     FEV+LPENELLHPPL+I VVD RAFGR
Sbjct: 1014 RPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGR 1073

Query: 525  YTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPE 584
             TLVG++ ++ L++F+ +  +  AP   T V   +    + +  +++ S+G    + +P 
Sbjct: 1074 STLVGTYTINYLKQFLCKLREPLAPI--TQVDGTQPGHDISDSLTATESSGAHSSSQDPP 1131

Query: 585  -----VPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEE---------- 629
                 V ++   T+V   A ++  + VDV +     + +    A+EP ++          
Sbjct: 1132 ADHIYVDVEPPPTVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPS 1191

Query: 630  -------------EPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLK 676
                         E  E+++DWWSKY+AS+                  +K +  N +G K
Sbjct: 1192 RRSTKRRKRTIADESAENVIDWWSKYYASLKKA---------------QKAKERNPKGKK 1236

Query: 677  GSMKGKEKARAAKEE---KKKKTQSSGSGQGSEAPEKKKPKIDE------LKVYPKELES 727
            G+ + K        E   KKKK +            KKKPK D       L++Y  +LES
Sbjct: 1237 GNTEAKPDEVVVDIEDGPKKKKDKML----------KKKPKDDGIPNLAILQIYDGDLES 1286

Query: 728  EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDST 787
            EF+NFEDW+ TF L RGK+ +D+ G  + +R++G+FKGS C+YK P  +D S E      
Sbjct: 1287 EFNNFEDWVKTFELFRGKSTEDDHG-LDGDRVIGKFKGSFCIYKSP--QDSSSEDS--GQ 1341

Query: 788  YGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQL 847
              + QGIP N P+ VL+RVY+V A +L PAD +GK+DPYI I+LGKT+I+D++ YI KQL
Sbjct: 1342 LRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQL 1401

Query: 848  NPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQT 907
            NPVFG+SF+I+A+FP ES+L++ +YD D++GTDDLIGETKIDLENRFYSKHRA CG+   
Sbjct: 1402 NPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQ 1461

Query: 908  YSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEI-EDENGQR 966
            Y   GYN WRD  KP++ILT+LCKD K+DGP+F P G++++ N+VF+G +   E++  + 
Sbjct: 1462 YEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHP-GKIQIGNQVFSGKTIFTEEDTDET 1520

Query: 967  KPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMP 1026
              + EH+AL  L  WEDIP  GCRLVPEH+ETRPL + DKPG+EQGRL++WVDMFP DMP
Sbjct: 1521 VESYEHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMP 1580

Query: 1027 APGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDT 1086
             PG P+DISPR+PK YELRV IWNT++V+LED++ FTG+KSSDI+V+GWLKG ++DKQ+T
Sbjct: 1581 QPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQET 1640

Query: 1087 DVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDAD 1146
            DVHY+SLTGEGNFNWR+LFPF YL AE+++VI+K+E++FS ++ E K PA L LQ+WD +
Sbjct: 1641 DVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFE 1700

Query: 1147 HFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARN 1206
              S+DDFLG +E++LN FPR AK+AK C +       +   +SIF+QKRV+GWWP     
Sbjct: 1701 RLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENASEETKISIFQQKRVRGWWPF---- 1756

Query: 1207 ENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARY 1266
             +   ELTGKVEAE HL+TAEEAEKNPVG AR EP+PL KPNRPDTSF WF++P K   Y
Sbjct: 1757 -SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFMSPFKCLYY 1815

Query: 1267 FLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1305
             +W  Y+  ++   +L++L++ L LF+Y++PG + ++I+
Sbjct: 1816 LIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIV 1854



 Score = 35.4 bits (80), Expect = 0.36
 Identities = 32/130 (24%), Positives = 49/130 (37%), Gaps = 21/130 (16%)

Query: 276 MYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHEL 335
           M      F  DS  L DPF  V F  Q   T V      P W + ++F  +         
Sbjct: 263 MANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM--------- 313

Query: 336 RDDPPI---IVIEIYDQDSMGKADFMGRTFAKPLVKMA-----DEAYCPPRFPPQLEYYQ 387
              PP+   + I+++D+ SM   D    T    L K++     D+ + P   P  +  Y 
Sbjct: 314 --FPPLCRRVKIQVWDEGSMN--DVALATHFIDLKKISNEQDGDKGFLPTFGPAWINLYG 369

Query: 388 IYRGNATAGD 397
             R ++   D
Sbjct: 370 SPRNHSLMDD 379


>gi|195976779 dysferlin isoform 1 [Homo sapiens]
          Length = 2119

 Score =  723 bits (1867), Expect = 0.0
 Identities = 418/1084 (38%), Positives = 593/1084 (54%), Gaps = 162/1084 (14%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1158 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1217

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1218 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1270

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 417
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1271 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1327

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1328 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1384

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1385 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1444

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGS---SSHSTGEVVVT----MEPEVPIKKL 590
             F+  P    +PS                GG    S  S GE V+      EP +PI+  
Sbjct: 1445 SFLCDPYSAESPS--------------PQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLA 1490

Query: 591  ETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMK 650
            + +  L  T+ A                       P     +E  +DWWSK+FASI    
Sbjct: 1491 DGLSSLAPTNTA----------------------SPPSSPHEEEFIDWWSKFFASIG--- 1525

Query: 651  EQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEK 710
                ++E  G  LE+                                             
Sbjct: 1526 ----EREKCGSYLEKD-------------------------------------------- 1537

Query: 711  KKPKIDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLC 768
                 D LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   
Sbjct: 1538 ----FDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFK 1589

Query: 769  VYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIA 828
            +Y  PLPED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI 
Sbjct: 1590 IY--PLPEDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIK 1643

Query: 829  IRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKI 888
            I +GK  + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +
Sbjct: 1644 ISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVV 1703

Query: 889  DLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKV 948
            DLENR  SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV  
Sbjct: 1704 DLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMF 1762

Query: 949  ANRVFTGPSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPD 1005
             ++ ++   EIE     N    P +E +AL  L+           LVPEHVE+RPL +P 
Sbjct: 1763 QDKEYS-IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPL 1813

Query: 1006 KPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGE 1065
            +P IEQG+L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGE
Sbjct: 1814 QPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGE 1872

Query: 1066 KSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMF 1125
            K SDI+V+GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +
Sbjct: 1873 KMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFW 1932

Query: 1126 SWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDV 1185
              D+TE KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++        
Sbjct: 1933 RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHP 1992

Query: 1186 P-LVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD-- 1242
               VS+F+QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+  
Sbjct: 1993 EWFVSLFEQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMN 2051

Query: 1243 -PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLV 1301
              LE P RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y  
Sbjct: 2052 PKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAA 2111

Query: 1302 KKIL 1305
             K++
Sbjct: 2112 MKLV 2115



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 21/211 (9%)

Query: 38  WPSITHTPDSQ----------EEGLNDIQEMIKTEKSYPE--RRLRGVLEELSCGCCRFL 85
           W  I+H  ++Q          E GL  +   +K + S  +    +  + +EL  GC +  
Sbjct: 683 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 740

Query: 86  SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 145
            L D  +  S+ T LD+   +     L  + + A  L+  +    +   L   +++L +L
Sbjct: 741 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAALEQAEDWLLRL 797

Query: 146 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 204
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 798 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 857

Query: 205 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 235
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 858 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 885



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 283 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 319
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 440 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 476



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 824 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 882
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 449 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 506

Query: 883 IGETKIDL 890
           +  T + +
Sbjct: 507 VATTYLSM 514


>gi|195976773 dysferlin isoform 5 [Homo sapiens]
          Length = 2088

 Score =  723 bits (1867), Expect = 0.0
 Identities = 418/1084 (38%), Positives = 593/1084 (54%), Gaps = 162/1084 (14%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1127 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1186

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1187 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1239

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 417
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1240 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1296

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1297 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1353

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1354 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1413

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGS---SSHSTGEVVVT----MEPEVPIKKL 590
             F+  P    +PS                GG    S  S GE V+      EP +PI+  
Sbjct: 1414 SFLCDPYSAESPS--------------PQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLA 1459

Query: 591  ETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMK 650
            + +  L  T+ A                       P     +E  +DWWSK+FASI    
Sbjct: 1460 DGLSSLAPTNTA----------------------SPPSSPHEEEFIDWWSKFFASIG--- 1494

Query: 651  EQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEK 710
                ++E  G  LE+                                             
Sbjct: 1495 ----EREKCGSYLEKD-------------------------------------------- 1506

Query: 711  KKPKIDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLC 768
                 D LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   
Sbjct: 1507 ----FDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFK 1558

Query: 769  VYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIA 828
            +Y  PLPED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI 
Sbjct: 1559 IY--PLPEDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIK 1612

Query: 829  IRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKI 888
            I +GK  + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +
Sbjct: 1613 ISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVV 1672

Query: 889  DLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKV 948
            DLENR  SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV  
Sbjct: 1673 DLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMF 1731

Query: 949  ANRVFTGPSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPD 1005
             ++ ++   EIE     N    P +E +AL  L+           LVPEHVE+RPL +P 
Sbjct: 1732 QDKEYS-IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPL 1782

Query: 1006 KPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGE 1065
            +P IEQG+L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGE
Sbjct: 1783 QPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGE 1841

Query: 1066 KSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMF 1125
            K SDI+V+GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +
Sbjct: 1842 KMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFW 1901

Query: 1126 SWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDV 1185
              D+TE KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++        
Sbjct: 1902 RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHP 1961

Query: 1186 P-LVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD-- 1242
               VS+F+QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+  
Sbjct: 1962 EWFVSLFEQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMN 2020

Query: 1243 -PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLV 1301
              LE P RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y  
Sbjct: 2021 PKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAA 2080

Query: 1302 KKIL 1305
             K++
Sbjct: 2081 MKLV 2084



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 21/211 (9%)

Query: 38  WPSITHTPDSQ----------EEGLNDIQEMIKTEKSYPE--RRLRGVLEELSCGCCRFL 85
           W  I+H  ++Q          E GL  +   +K + S  +    +  + +EL  GC +  
Sbjct: 652 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 709

Query: 86  SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 145
            L D  +  S+ T LD+   +     L  + + A  L+  +    +   L   +++L +L
Sbjct: 710 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAALEQAEDWLLRL 766

Query: 146 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 204
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 767 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 826

Query: 205 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 235
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 827 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 854



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 283 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 319
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 409 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 445



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 824 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 882
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 418 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 475

Query: 883 IGETKIDL 890
           +  T + +
Sbjct: 476 VATTYLSM 483


>gi|195976769 dysferlin isoform 6 [Homo sapiens]
          Length = 2102

 Score =  723 bits (1867), Expect = 0.0
 Identities = 418/1084 (38%), Positives = 593/1084 (54%), Gaps = 162/1084 (14%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1141 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1200

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1201 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1253

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 417
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1254 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1310

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1311 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1367

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1368 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1427

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGS---SSHSTGEVVVT----MEPEVPIKKL 590
             F+  P    +PS                GG    S  S GE V+      EP +PI+  
Sbjct: 1428 SFLCDPYSAESPS--------------PQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLA 1473

Query: 591  ETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMK 650
            + +  L  T+ A                       P     +E  +DWWSK+FASI    
Sbjct: 1474 DGLSSLAPTNTA----------------------SPPSSPHEEEFIDWWSKFFASIG--- 1508

Query: 651  EQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEK 710
                ++E  G  LE+                                             
Sbjct: 1509 ----EREKCGSYLEKD-------------------------------------------- 1520

Query: 711  KKPKIDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLC 768
                 D LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   
Sbjct: 1521 ----FDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFK 1572

Query: 769  VYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIA 828
            +Y  PLPED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI 
Sbjct: 1573 IY--PLPEDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIK 1626

Query: 829  IRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKI 888
            I +GK  + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +
Sbjct: 1627 ISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVV 1686

Query: 889  DLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKV 948
            DLENR  SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV  
Sbjct: 1687 DLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMF 1745

Query: 949  ANRVFTGPSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPD 1005
             ++ ++   EIE     N    P +E +AL  L+           LVPEHVE+RPL +P 
Sbjct: 1746 QDKEYS-IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPL 1796

Query: 1006 KPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGE 1065
            +P IEQG+L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGE
Sbjct: 1797 QPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGE 1855

Query: 1066 KSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMF 1125
            K SDI+V+GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +
Sbjct: 1856 KMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFW 1915

Query: 1126 SWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDV 1185
              D+TE KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++        
Sbjct: 1916 RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHP 1975

Query: 1186 P-LVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD-- 1242
               VS+F+QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+  
Sbjct: 1976 EWFVSLFEQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMN 2034

Query: 1243 -PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLV 1301
              LE P RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y  
Sbjct: 2035 PKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAA 2094

Query: 1302 KKIL 1305
             K++
Sbjct: 2095 MKLV 2098



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 21/211 (9%)

Query: 38  WPSITHTPDSQ----------EEGLNDIQEMIKTEKSYPE--RRLRGVLEELSCGCCRFL 85
           W  I+H  ++Q          E GL  +   +K + S  +    +  + +EL  GC +  
Sbjct: 666 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 723

Query: 86  SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 145
            L D  +  S+ T LD+   +     L  + + A  L+  +    +   L   +++L +L
Sbjct: 724 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAALEQAEDWLLRL 780

Query: 146 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 204
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 781 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 840

Query: 205 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 235
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 841 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 868



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 283 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 319
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 409 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 445



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 824 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 882
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 418 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 475

Query: 883 IGETKIDL 890
           +  T + +
Sbjct: 476 VATTYLSM 483


>gi|195976764 dysferlin isoform 14 [Homo sapiens]
          Length = 2118

 Score =  723 bits (1867), Expect = 0.0
 Identities = 418/1084 (38%), Positives = 593/1084 (54%), Gaps = 162/1084 (14%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1157 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1216

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1217 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1269

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 417
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1270 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1326

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1327 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1383

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1384 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1443

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGS---SSHSTGEVVVT----MEPEVPIKKL 590
             F+  P    +PS                GG    S  S GE V+      EP +PI+  
Sbjct: 1444 SFLCDPYSAESPS--------------PQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLA 1489

Query: 591  ETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMK 650
            + +  L  T+ A                       P     +E  +DWWSK+FASI    
Sbjct: 1490 DGLSSLAPTNTA----------------------SPPSSPHEEEFIDWWSKFFASIG--- 1524

Query: 651  EQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEK 710
                ++E  G  LE+                                             
Sbjct: 1525 ----EREKCGSYLEKD-------------------------------------------- 1536

Query: 711  KKPKIDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLC 768
                 D LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   
Sbjct: 1537 ----FDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFK 1588

Query: 769  VYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIA 828
            +Y  PLPED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI 
Sbjct: 1589 IY--PLPEDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIK 1642

Query: 829  IRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKI 888
            I +GK  + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +
Sbjct: 1643 ISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVV 1702

Query: 889  DLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKV 948
            DLENR  SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV  
Sbjct: 1703 DLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMF 1761

Query: 949  ANRVFTGPSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPD 1005
             ++ ++   EIE     N    P +E +AL  L+           LVPEHVE+RPL +P 
Sbjct: 1762 QDKEYS-IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPL 1812

Query: 1006 KPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGE 1065
            +P IEQG+L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGE
Sbjct: 1813 QPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGE 1871

Query: 1066 KSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMF 1125
            K SDI+V+GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +
Sbjct: 1872 KMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFW 1931

Query: 1126 SWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDV 1185
              D+TE KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++        
Sbjct: 1932 RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHP 1991

Query: 1186 P-LVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD-- 1242
               VS+F+QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+  
Sbjct: 1992 EWFVSLFEQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMN 2050

Query: 1243 -PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLV 1301
              LE P RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y  
Sbjct: 2051 PKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAA 2110

Query: 1302 KKIL 1305
             K++
Sbjct: 2111 MKLV 2114



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 21/211 (9%)

Query: 38  WPSITHTPDSQ----------EEGLNDIQEMIKTEKSYPE--RRLRGVLEELSCGCCRFL 85
           W  I+H  ++Q          E GL  +   +K + S  +    +  + +EL  GC +  
Sbjct: 682 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 739

Query: 86  SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 145
            L D  +  S+ T LD+   +     L  + + A  L+  +    +   L   +++L +L
Sbjct: 740 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAALEQAEDWLLRL 796

Query: 146 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 204
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 797 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 856

Query: 205 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 235
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 857 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 884



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 283 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 319
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 439 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 475



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 824 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 882
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 448 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 505

Query: 883 IGETKIDL 890
           +  T + +
Sbjct: 506 VATTYLSM 513


>gi|195976758 dysferlin isoform 11 [Homo sapiens]
          Length = 2101

 Score =  723 bits (1867), Expect = 0.0
 Identities = 418/1084 (38%), Positives = 593/1084 (54%), Gaps = 162/1084 (14%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1140 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1199

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1200 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1252

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 417
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1253 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1309

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1310 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1366

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1367 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1426

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGS---SSHSTGEVVVT----MEPEVPIKKL 590
             F+  P    +PS                GG    S  S GE V+      EP +PI+  
Sbjct: 1427 SFLCDPYSAESPS--------------PQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLA 1472

Query: 591  ETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMK 650
            + +  L  T+ A                       P     +E  +DWWSK+FASI    
Sbjct: 1473 DGLSSLAPTNTA----------------------SPPSSPHEEEFIDWWSKFFASIG--- 1507

Query: 651  EQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEK 710
                ++E  G  LE+                                             
Sbjct: 1508 ----EREKCGSYLEKD-------------------------------------------- 1519

Query: 711  KKPKIDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLC 768
                 D LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   
Sbjct: 1520 ----FDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFK 1571

Query: 769  VYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIA 828
            +Y  PLPED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI 
Sbjct: 1572 IY--PLPEDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIK 1625

Query: 829  IRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKI 888
            I +GK  + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +
Sbjct: 1626 ISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVV 1685

Query: 889  DLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKV 948
            DLENR  SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV  
Sbjct: 1686 DLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMF 1744

Query: 949  ANRVFTGPSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPD 1005
             ++ ++   EIE     N    P +E +AL  L+           LVPEHVE+RPL +P 
Sbjct: 1745 QDKEYS-IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPL 1795

Query: 1006 KPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGE 1065
            +P IEQG+L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGE
Sbjct: 1796 QPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGE 1854

Query: 1066 KSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMF 1125
            K SDI+V+GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +
Sbjct: 1855 KMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFW 1914

Query: 1126 SWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDV 1185
              D+TE KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++        
Sbjct: 1915 RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHP 1974

Query: 1186 P-LVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD-- 1242
               VS+F+QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+  
Sbjct: 1975 EWFVSLFEQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMN 2033

Query: 1243 -PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLV 1301
              LE P RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y  
Sbjct: 2034 PKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAA 2093

Query: 1302 KKIL 1305
             K++
Sbjct: 2094 MKLV 2097



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 21/211 (9%)

Query: 38  WPSITHTPDSQ----------EEGLNDIQEMIKTEKSYPE--RRLRGVLEELSCGCCRFL 85
           W  I+H  ++Q          E GL  +   +K + S  +    +  + +EL  GC +  
Sbjct: 665 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 722

Query: 86  SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 145
            L D  +  S+ T LD+   +     L  + + A  L+  +    +   L   +++L +L
Sbjct: 723 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAALEQAEDWLLRL 779

Query: 146 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 204
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 780 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 839

Query: 205 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 235
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 840 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 867



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 283 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 319
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 408 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 444



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 824 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 882
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 417 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 474

Query: 883 IGETKIDL 890
           +  T + +
Sbjct: 475 VATTYLSM 482


>gi|195976756 dysferlin isoform 10 [Homo sapiens]
          Length = 2087

 Score =  723 bits (1867), Expect = 0.0
 Identities = 418/1084 (38%), Positives = 593/1084 (54%), Gaps = 162/1084 (14%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1126 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1185

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1186 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1238

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 417
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1239 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1295

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1296 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1352

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1353 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1412

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGS---SSHSTGEVVVT----MEPEVPIKKL 590
             F+  P    +PS                GG    S  S GE V+      EP +PI+  
Sbjct: 1413 SFLCDPYSAESPS--------------PQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLA 1458

Query: 591  ETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMK 650
            + +  L  T+ A                       P     +E  +DWWSK+FASI    
Sbjct: 1459 DGLSSLAPTNTA----------------------SPPSSPHEEEFIDWWSKFFASIG--- 1493

Query: 651  EQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEK 710
                ++E  G  LE+                                             
Sbjct: 1494 ----EREKCGSYLEKD-------------------------------------------- 1505

Query: 711  KKPKIDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLC 768
                 D LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   
Sbjct: 1506 ----FDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFK 1557

Query: 769  VYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIA 828
            +Y  PLPED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI 
Sbjct: 1558 IY--PLPEDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIK 1611

Query: 829  IRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKI 888
            I +GK  + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +
Sbjct: 1612 ISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVV 1671

Query: 889  DLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKV 948
            DLENR  SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV  
Sbjct: 1672 DLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMF 1730

Query: 949  ANRVFTGPSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPD 1005
             ++ ++   EIE     N    P +E +AL  L+           LVPEHVE+RPL +P 
Sbjct: 1731 QDKEYS-IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPL 1781

Query: 1006 KPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGE 1065
            +P IEQG+L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGE
Sbjct: 1782 QPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGE 1840

Query: 1066 KSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMF 1125
            K SDI+V+GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +
Sbjct: 1841 KMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFW 1900

Query: 1126 SWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDV 1185
              D+TE KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++        
Sbjct: 1901 RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHP 1960

Query: 1186 P-LVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD-- 1242
               VS+F+QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+  
Sbjct: 1961 EWFVSLFEQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMN 2019

Query: 1243 -PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLV 1301
              LE P RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y  
Sbjct: 2020 PKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAA 2079

Query: 1302 KKIL 1305
             K++
Sbjct: 2080 MKLV 2083



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 21/211 (9%)

Query: 38  WPSITHTPDSQ----------EEGLNDIQEMIKTEKSYPE--RRLRGVLEELSCGCCRFL 85
           W  I+H  ++Q          E GL  +   +K + S  +    +  + +EL  GC +  
Sbjct: 651 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 708

Query: 86  SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 145
            L D  +  S+ T LD+   +     L  + + A  L+  +    +   L   +++L +L
Sbjct: 709 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAALEQAEDWLLRL 765

Query: 146 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 204
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 766 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 825

Query: 205 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 235
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 826 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 853



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 283 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 319
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 408 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 444



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 824 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 882
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 417 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 474

Query: 883 IGETKIDL 890
           +  T + +
Sbjct: 475 VATTYLSM 482


>gi|195976821 dysferlin isoform 2 [Homo sapiens]
          Length = 2081

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1141 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1200

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1201 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1253

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 417
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1254 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1310

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1311 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1367

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1368 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1427

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 597
             F+  P    +PS                GG    S                      L 
Sbjct: 1428 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1452

Query: 598  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 657
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1453 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1490

Query: 658  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 717
              G  LE+                                                  D 
Sbjct: 1491 KCGSYLEKD------------------------------------------------FDT 1502

Query: 718  LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 775
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1503 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1556

Query: 776  EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 835
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1557 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1612

Query: 836  IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 895
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1613 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1672

Query: 896  SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 955
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1673 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1730

Query: 956  PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1012
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1731 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1782

Query: 1013 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1072
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1783 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1841

Query: 1073 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1132
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1842 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1901

Query: 1133 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1191
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1902 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1961

Query: 1192 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1248
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1962 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2020

Query: 1249 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1305
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2021 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2077



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 21/211 (9%)

Query: 38  WPSITHTPDSQ----------EEGLNDIQEMIKTEKSYPE--RRLRGVLEELSCGCCRFL 85
           W  I+H  ++Q          E GL  +   +K + S  +    +  + +EL  GC +  
Sbjct: 666 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 723

Query: 86  SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 145
            L D  +  S+ T LD+   +     L  + + A  L+  +    +   L   +++L +L
Sbjct: 724 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAALEQAEDWLLRL 780

Query: 146 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 204
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 781 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 840

Query: 205 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 235
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 841 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 868



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 283 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 319
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 409 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 445



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 824 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 882
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 418 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 475

Query: 883 IGETKIDL 890
           +  T + +
Sbjct: 476 VATTYLSM 483


>gi|4503431 dysferlin isoform 8 [Homo sapiens]
          Length = 2080

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1140 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1199

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1200 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1252

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 417
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1253 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1309

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1310 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1366

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1367 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1426

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 597
             F+  P    +PS                GG    S                      L 
Sbjct: 1427 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1451

Query: 598  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 657
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1452 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1489

Query: 658  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 717
              G  LE+                                                  D 
Sbjct: 1490 KCGSYLEKD------------------------------------------------FDT 1501

Query: 718  LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 775
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1502 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1555

Query: 776  EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 835
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1556 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1611

Query: 836  IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 895
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1612 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1671

Query: 896  SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 955
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1672 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1729

Query: 956  PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1012
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1730 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1781

Query: 1013 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1072
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1782 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1840

Query: 1073 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1132
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1841 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1900

Query: 1133 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1191
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1901 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1960

Query: 1192 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1248
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1961 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2019

Query: 1249 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1305
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2020 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2076



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 21/211 (9%)

Query: 38  WPSITHTPDSQ----------EEGLNDIQEMIKTEKSYPE--RRLRGVLEELSCGCCRFL 85
           W  I+H  ++Q          E GL  +   +K + S  +    +  + +EL  GC +  
Sbjct: 665 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 722

Query: 86  SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 145
            L D  +  S+ T LD+   +     L  + + A  L+  +    +   L   +++L +L
Sbjct: 723 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAALEQAEDWLLRL 779

Query: 146 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 204
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 780 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 839

Query: 205 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 235
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 840 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 867



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 283 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 319
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 408 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 444



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 824 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 882
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 417 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 474

Query: 883 IGETKIDL 890
           +  T + +
Sbjct: 475 VATTYLSM 482


>gi|195976777 dysferlin isoform 3 [Homo sapiens]
          Length = 2067

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1127 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1186

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1187 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1239

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 417
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1240 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1296

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1297 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1353

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1354 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1413

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 597
             F+  P    +PS                GG    S                      L 
Sbjct: 1414 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1438

Query: 598  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 657
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1439 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1476

Query: 658  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 717
              G  LE+                                                  D 
Sbjct: 1477 KCGSYLEKD------------------------------------------------FDT 1488

Query: 718  LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 775
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1489 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1542

Query: 776  EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 835
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1543 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1598

Query: 836  IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 895
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1599 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1658

Query: 896  SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 955
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1659 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1716

Query: 956  PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1012
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1717 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1768

Query: 1013 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1072
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1769 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1827

Query: 1073 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1132
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1828 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1887

Query: 1133 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1191
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1888 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1947

Query: 1192 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1248
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1948 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2006

Query: 1249 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1305
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2007 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2063



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 21/211 (9%)

Query: 38  WPSITHTPDSQ----------EEGLNDIQEMIKTEKSYPE--RRLRGVLEELSCGCCRFL 85
           W  I+H  ++Q          E GL  +   +K + S  +    +  + +EL  GC +  
Sbjct: 652 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 709

Query: 86  SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 145
            L D  +  S+ T LD+   +     L  + + A  L+  +    +   L   +++L +L
Sbjct: 710 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAALEQAEDWLLRL 766

Query: 146 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 204
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 767 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 826

Query: 205 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 235
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 827 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 854



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 283 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 319
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 409 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 445



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 824 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 882
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 418 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 475

Query: 883 IGETKIDL 890
           +  T + +
Sbjct: 476 VATTYLSM 483


>gi|195976775 dysferlin isoform 4 [Homo sapiens]
          Length = 2098

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1158 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1217

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1218 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1270

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 417
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1271 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1327

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1328 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1384

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1385 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1444

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 597
             F+  P    +PS                GG    S                      L 
Sbjct: 1445 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1469

Query: 598  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 657
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1470 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1507

Query: 658  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 717
              G  LE+                                                  D 
Sbjct: 1508 KCGSYLEKD------------------------------------------------FDT 1519

Query: 718  LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 775
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1520 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1573

Query: 776  EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 835
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1574 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1629

Query: 836  IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 895
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1630 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1689

Query: 896  SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 955
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1690 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1747

Query: 956  PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1012
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1748 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1799

Query: 1013 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1072
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1800 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1858

Query: 1073 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1132
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1859 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1918

Query: 1133 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1191
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1919 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1978

Query: 1192 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1248
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1979 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2037

Query: 1249 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1305
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2038 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2094



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 21/211 (9%)

Query: 38  WPSITHTPDSQ----------EEGLNDIQEMIKTEKSYPE--RRLRGVLEELSCGCCRFL 85
           W  I+H  ++Q          E GL  +   +K + S  +    +  + +EL  GC +  
Sbjct: 683 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 740

Query: 86  SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 145
            L D  +  S+ T LD+   +     L  + + A  L+  +    +   L   +++L +L
Sbjct: 741 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAALEQAEDWLLRL 797

Query: 146 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 204
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 798 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 857

Query: 205 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 235
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 858 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 885



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 283 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 319
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 440 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 476



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 824 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 882
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 449 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 506

Query: 883 IGETKIDL 890
           +  T + +
Sbjct: 507 VATTYLSM 514


>gi|195976766 dysferlin isoform 7 [Homo sapiens]
          Length = 2112

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1172 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1231

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1232 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1284

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 417
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1285 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1341

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1342 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1398

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1399 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1458

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 597
             F+  P    +PS                GG    S                      L 
Sbjct: 1459 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1483

Query: 598  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 657
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1484 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1521

Query: 658  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 717
              G  LE+                                                  D 
Sbjct: 1522 KCGSYLEKD------------------------------------------------FDT 1533

Query: 718  LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 775
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1534 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1587

Query: 776  EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 835
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1588 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1643

Query: 836  IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 895
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1644 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1703

Query: 896  SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 955
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1704 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1761

Query: 956  PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1012
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1762 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1813

Query: 1013 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1072
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1814 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1872

Query: 1073 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1132
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1873 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1932

Query: 1133 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1191
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1933 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1992

Query: 1192 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1248
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1993 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2051

Query: 1249 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1305
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2052 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2108



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 21/211 (9%)

Query: 38  WPSITHTPDSQ----------EEGLNDIQEMIKTEKSYPE--RRLRGVLEELSCGCCRFL 85
           W  I+H  ++Q          E GL  +   +K + S  +    +  + +EL  GC +  
Sbjct: 697 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 754

Query: 86  SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 145
            L D  +  S+ T LD+   +     L  + + A  L+  +    +   L   +++L +L
Sbjct: 755 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAALEQAEDWLLRL 811

Query: 146 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 204
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 812 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 871

Query: 205 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 235
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 872 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 899



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 283 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 319
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 440 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 476



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 824 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 882
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 449 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 506

Query: 883 IGETKIDL 890
           +  T + +
Sbjct: 507 VATTYLSM 514


>gi|195976762 dysferlin isoform 13 [Homo sapiens]
          Length = 2097

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1157 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1216

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1217 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1269

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 417
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1270 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1326

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1327 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1383

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1384 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1443

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 597
             F+  P    +PS                GG    S                      L 
Sbjct: 1444 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1468

Query: 598  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 657
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1469 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1506

Query: 658  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 717
              G  LE+                                                  D 
Sbjct: 1507 KCGSYLEKD------------------------------------------------FDT 1518

Query: 718  LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 775
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1519 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1572

Query: 776  EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 835
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1573 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1628

Query: 836  IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 895
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1629 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1688

Query: 896  SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 955
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1689 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1746

Query: 956  PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1012
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1747 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1798

Query: 1013 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1072
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1799 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1857

Query: 1073 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1132
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1858 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1917

Query: 1133 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1191
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1918 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1977

Query: 1192 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1248
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1978 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2036

Query: 1249 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1305
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2037 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2093



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 21/211 (9%)

Query: 38  WPSITHTPDSQ----------EEGLNDIQEMIKTEKSYPE--RRLRGVLEELSCGCCRFL 85
           W  I+H  ++Q          E GL  +   +K + S  +    +  + +EL  GC +  
Sbjct: 682 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 739

Query: 86  SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 145
            L D  +  S+ T LD+   +     L  + + A  L+  +    +   L   +++L +L
Sbjct: 740 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAALEQAEDWLLRL 796

Query: 146 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 204
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 797 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 856

Query: 205 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 235
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 857 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 884



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 283 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 319
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 439 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 475



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 824 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 882
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 448 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 505

Query: 883 IGETKIDL 890
           +  T + +
Sbjct: 506 VATTYLSM 513


>gi|195976760 dysferlin isoform 12 [Homo sapiens]
          Length = 2111

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1171 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1230

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1231 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1283

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 417
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1284 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1340

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1341 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1397

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1398 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1457

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 597
             F+  P    +PS                GG    S                      L 
Sbjct: 1458 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1482

Query: 598  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 657
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1483 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1520

Query: 658  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 717
              G  LE+                                                  D 
Sbjct: 1521 KCGSYLEKD------------------------------------------------FDT 1532

Query: 718  LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 775
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1533 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1586

Query: 776  EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 835
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1587 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1642

Query: 836  IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 895
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1643 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1702

Query: 896  SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 955
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1703 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1760

Query: 956  PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1012
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1761 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1812

Query: 1013 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1072
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1813 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1871

Query: 1073 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1132
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1872 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1931

Query: 1133 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1191
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1932 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1991

Query: 1192 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1248
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1992 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2050

Query: 1249 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1305
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2051 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2107



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 21/211 (9%)

Query: 38  WPSITHTPDSQ----------EEGLNDIQEMIKTEKSYPE--RRLRGVLEELSCGCCRFL 85
           W  I+H  ++Q          E GL  +   +K + S  +    +  + +EL  GC +  
Sbjct: 696 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 753

Query: 86  SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 145
            L D  +  S+ T LD+   +     L  + + A  L+  +    +   L   +++L +L
Sbjct: 754 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAALEQAEDWLLRL 810

Query: 146 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 204
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 811 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 870

Query: 205 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 235
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 871 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 898



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 283 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 319
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 439 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 475



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 824 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 882
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 448 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 505

Query: 883 IGETKIDL 890
           +  T + +
Sbjct: 506 VATTYLSM 513


>gi|195976754 dysferlin isoform 9 [Homo sapiens]
          Length = 2066

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1126 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1185

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1186 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1238

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 417
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1239 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1295

Query: 418  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 477
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1296 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1352

Query: 478  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 537
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1353 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1412

Query: 538  RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 597
             F+  P    +PS                GG    S                      L 
Sbjct: 1413 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1437

Query: 598  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 657
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1438 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1475

Query: 658  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 717
              G  LE+                                                  D 
Sbjct: 1476 KCGSYLEKD------------------------------------------------FDT 1487

Query: 718  LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 775
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1488 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1541

Query: 776  EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 835
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1542 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1597

Query: 836  IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 895
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1598 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1657

Query: 896  SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 955
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1658 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1715

Query: 956  PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1012
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1716 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1767

Query: 1013 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1072
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1768 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1826

Query: 1073 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1132
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1827 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1886

Query: 1133 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1191
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1887 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1946

Query: 1192 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1248
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1947 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2005

Query: 1249 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1305
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2006 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2062



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 21/211 (9%)

Query: 38  WPSITHTPDSQ----------EEGLNDIQEMIKTEKSYPE--RRLRGVLEELSCGCCRFL 85
           W  I+H  ++Q          E GL  +   +K + S  +    +  + +EL  GC +  
Sbjct: 651 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 708

Query: 86  SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 145
            L D  +  S+ T LD+   +     L  + + A  L+  +    +   L   +++L +L
Sbjct: 709 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAALALK--LGHSELPAALEQAEDWLLRL 765

Query: 146 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 204
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 766 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 825

Query: 205 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 235
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 826 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 853



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 283 FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 319
           F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 408 FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 444



 Score = 30.8 bits (68), Expect = 8.9
 Identities = 15/68 (22%), Positives = 33/68 (48%), Gaps = 3/68 (4%)

Query: 824 DPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFP-MESMLTVAVYDWDLVGTDDL 882
           DP++ +      +  K   + K  NP + ++  + A FP M   + + + DWD +  +D+
Sbjct: 417 DPFVEVSFAGKMLCSK--ILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI 474

Query: 883 IGETKIDL 890
           +  T + +
Sbjct: 475 VATTYLSM 482


>gi|19718759 myoferlin isoform b [Homo sapiens]
          Length = 2048

 Score =  684 bits (1764), Expect = 0.0
 Identities = 395/1062 (37%), Positives = 580/1062 (54%), Gaps = 145/1062 (13%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P VS  + +   + LR ++YQAR+L A D    SDP+A + F+++S+ TE+++ TL PTW
Sbjct: 1114 PIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTW 1173

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ ++FD +E+YGE   +  +PP +++E++D D +GK +F+GR+   P+VK+  E     
Sbjct: 1174 DQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM---- 1229

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK--ADLPPINGPVDVDRGPIMPVPMG 435
               P+L ++ +  G+   GD+L   EL+  G  G     LPP   P       +  VP G
Sbjct: 1230 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAP------NLYMVPQG 1283

Query: 436  IRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLV 495
            IRPV+    +E+L WGLR++K   +A +  P + +EC G+ V+S +I N KK PNF + V
Sbjct: 1284 IRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSV 1343

Query: 496  KWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF---IYRPPDRSAPSWN 552
             + +V LP+ EL  PPL I+V+D R FGR  +VG   +  L RF    Y   +   P   
Sbjct: 1344 LFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLK 1403

Query: 553  TTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEE 612
             ++     CR             ++V+ ME   P+                    +A + 
Sbjct: 1404 ASLLSAPPCR-------------DIVIEMEDTKPL--------------------LASKL 1430

Query: 613  KEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNT 672
             EK                +E ++DWWSK++AS         + E  G  ++        
Sbjct: 1431 TEK----------------EEEIVDWWSKFYASSG-------EHEKCGQYIQ-------- 1459

Query: 673  EGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNF 732
                   KG  K +    E +   +  G                              +F
Sbjct: 1460 -------KGYSKLKIYNCELENVAEFEG----------------------------LTDF 1484

Query: 733  EDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQ 792
             D   TF L RGK+ ++ED S     +VG FKGS  +Y  PLP+D S  A        F+
Sbjct: 1485 SD---TFKLYRGKSDENEDPS-----VVGEFKGSFRIY--PLPDDPSVPA----PPRQFR 1530

Query: 793  GIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFG 852
             +P + P    VR+Y+VR  +L P D NG  DPYI I LGK  I D+++YI   LNPVFG
Sbjct: 1531 ELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFG 1590

Query: 853  KSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 912
            + +++    P E  L ++VYD+D    D+ +GET IDLENRF S+  + CGI + Y   G
Sbjct: 1591 RMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSG 1650

Query: 913  YNIWRDPMKPSQILTRLCKDGKVDGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDE 971
             N WRD ++P+Q+L  + +      P     G R++   R ++      DE    K   +
Sbjct: 1651 VNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYS-----LDEFEANKILHQ 1705

Query: 972  HVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTP 1031
            H+     R    I R    LVPEHVETR L +  +P I QG+L++WVD+FP  +  PG P
Sbjct: 1706 HLGAPEERLALHILRTQ-GLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPP 1764

Query: 1032 LDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYH 1091
             +I+PRK KKY LRVIIWNT +V+L D+   TGE+ SDI+V+GW+ G +E+KQ TDVHY 
Sbjct: 1765 FNITPRKAKKYYLRVIIWNTKDVIL-DEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYR 1823

Query: 1092 SLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSAD 1151
            SL GEGNFNWR++FPFDYL AE+  +++KKE  +S D+TE++IP RL +QIWD D FS D
Sbjct: 1824 SLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLD 1883

Query: 1152 DFLGAIELDLNRFPRGAKTAKQCTMEM-----ATGEVDVPLVSIFKQKRVKGWWPLLARN 1206
            D+LG +ELDL      AK+ ++C ++M     A   +     S+F+QK +KGWWP  A  
Sbjct: 1884 DYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEK 1943

Query: 1207 ENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTSFIWFLNPLKS 1263
            +     + GKVE  L +L  +EA++ P G  R+EP+    L+ PNRP+TSF+WF NP K+
Sbjct: 1944 DGARV-MAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKT 2002

Query: 1264 ARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1305
             ++ +W  ++W+++ LL LL+LLL +A+ LYS+P YL  KI+
Sbjct: 2003 MKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIV 2044



 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 53/145 (36%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 92  QGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADE 151
           +G ++ T LD +  K   R L  + + A  +R++     V+  L   +++L KL  L +E
Sbjct: 697 EGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEAT--DVKSTLAEIEDWLDKLMQLTEE 754

Query: 152 PQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIV-EEETGKDCAKVKTLFLKLPGKRGFG 210
           PQ+S+PDI IWM+   KR+AYAR+P+  +L+S   E  +GK C K +T+FLK P ++  G
Sbjct: 755 PQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNG 814

Query: 211 SAGWTVQAKVELYLWLGLSKQRKEF 235
                V  ++ + +WLGLS   K+F
Sbjct: 815 P---KVPVELRVNIWLGLSAVEKKF 836



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 8/78 (10%)

Query: 285 ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 344
           AD   L DPF  V F  +  CT ++ +   P W+Q++   NL++     +       I +
Sbjct: 389 ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV---NLQI-----KFPSVCEKIKL 440

Query: 345 EIYDQDSMGKADFMGRTF 362
            IYD D + K D +G T+
Sbjct: 441 TIYDWDRLTKNDVVGTTY 458



 Score = 37.7 bits (86), Expect = 0.073
 Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 3/75 (4%)

Query: 817 ADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPME-SMLTVAVYDWD 875
           AD     DP++ +      +    N I K  NP + +  +++  FP     + + +YDWD
Sbjct: 389 ADKKNLVDPFVEVSFAGKKVCT--NIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWD 446

Query: 876 LVGTDDLIGETKIDL 890
            +  +D++G T + L
Sbjct: 447 RLTKNDVVGTTYLHL 461



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 796 SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 855
           SN P +  +RV V+    L   +I      ++  +  +T I+   N    +L   F  + 
Sbjct: 193 SNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDEL---FFYNV 249

Query: 856 DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDL 890
           ++  S  M+ ++++ VY+   +  D L+GE KID+
Sbjct: 250 NMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV 284


>gi|7305053 myoferlin isoform a [Homo sapiens]
          Length = 2061

 Score =  684 bits (1764), Expect = 0.0
 Identities = 395/1062 (37%), Positives = 580/1062 (54%), Gaps = 145/1062 (13%)

Query: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317
            P VS  + +   + LR ++YQAR+L A D    SDP+A + F+++S+ TE+++ TL PTW
Sbjct: 1127 PIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTW 1186

Query: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377
            DQ ++FD +E+YGE   +  +PP +++E++D D +GK +F+GR+   P+VK+  E     
Sbjct: 1187 DQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM---- 1242

Query: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK--ADLPPINGPVDVDRGPIMPVPMG 435
               P+L ++ +  G+   GD+L   EL+  G  G     LPP   P       +  VP G
Sbjct: 1243 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAP------NLYMVPQG 1296

Query: 436  IRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLV 495
            IRPV+    +E+L WGLR++K   +A +  P + +EC G+ V+S +I N KK PNF + V
Sbjct: 1297 IRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSV 1356

Query: 496  KWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF---IYRPPDRSAPSWN 552
             + +V LP+ EL  PPL I+V+D R FGR  +VG   +  L RF    Y   +   P   
Sbjct: 1357 LFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLK 1416

Query: 553  TTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEE 612
             ++     CR             ++V+ ME   P+                    +A + 
Sbjct: 1417 ASLLSAPPCR-------------DIVIEMEDTKPL--------------------LASKL 1443

Query: 613  KEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNT 672
             EK                +E ++DWWSK++AS         + E  G  ++        
Sbjct: 1444 TEK----------------EEEIVDWWSKFYASSG-------EHEKCGQYIQ-------- 1472

Query: 673  EGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNF 732
                   KG  K +    E +   +  G                              +F
Sbjct: 1473 -------KGYSKLKIYNCELENVAEFEG----------------------------LTDF 1497

Query: 733  EDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQ 792
             D   TF L RGK+ ++ED S     +VG FKGS  +Y  PLP+D S  A        F+
Sbjct: 1498 SD---TFKLYRGKSDENEDPS-----VVGEFKGSFRIY--PLPDDPSVPA----PPRQFR 1543

Query: 793  GIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFG 852
             +P + P    VR+Y+VR  +L P D NG  DPYI I LGK  I D+++YI   LNPVFG
Sbjct: 1544 ELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFG 1603

Query: 853  KSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 912
            + +++    P E  L ++VYD+D    D+ +GET IDLENRF S+  + CGI + Y   G
Sbjct: 1604 RMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSG 1663

Query: 913  YNIWRDPMKPSQILTRLCKDGKVDGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDE 971
             N WRD ++P+Q+L  + +      P     G R++   R ++      DE    K   +
Sbjct: 1664 VNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYS-----LDEFEANKILHQ 1718

Query: 972  HVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTP 1031
            H+     R    I R    LVPEHVETR L +  +P I QG+L++WVD+FP  +  PG P
Sbjct: 1719 HLGAPEERLALHILRTQ-GLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPP 1777

Query: 1032 LDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYH 1091
             +I+PRK KKY LRVIIWNT +V+L D+   TGE+ SDI+V+GW+ G +E+KQ TDVHY 
Sbjct: 1778 FNITPRKAKKYYLRVIIWNTKDVIL-DEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYR 1836

Query: 1092 SLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSAD 1151
            SL GEGNFNWR++FPFDYL AE+  +++KKE  +S D+TE++IP RL +QIWD D FS D
Sbjct: 1837 SLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLD 1896

Query: 1152 DFLGAIELDLNRFPRGAKTAKQCTMEM-----ATGEVDVPLVSIFKQKRVKGWWPLLARN 1206
            D+LG +ELDL      AK+ ++C ++M     A   +     S+F+QK +KGWWP  A  
Sbjct: 1897 DYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEK 1956

Query: 1207 ENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTSFIWFLNPLKS 1263
            +     + GKVE  L +L  +EA++ P G  R+EP+    L+ PNRP+TSF+WF NP K+
Sbjct: 1957 DGARV-MAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKT 2015

Query: 1264 ARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1305
             ++ +W  ++W+++ LL LL+LLL +A+ LYS+P YL  KI+
Sbjct: 2016 MKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIV 2057



 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 53/145 (36%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 92  QGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADE 151
           +G ++ T LD +  K   R L  + + A  +R++     V+  L   +++L KL  L +E
Sbjct: 710 EGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEAT--DVKSTLAEIEDWLDKLMQLTEE 767

Query: 152 PQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIV-EEETGKDCAKVKTLFLKLPGKRGFG 210
           PQ+S+PDI IWM+   KR+AYAR+P+  +L+S   E  +GK C K +T+FLK P ++  G
Sbjct: 768 PQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNG 827

Query: 211 SAGWTVQAKVELYLWLGLSKQRKEF 235
                V  ++ + +WLGLS   K+F
Sbjct: 828 P---KVPVELRVNIWLGLSAVEKKF 849



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 8/78 (10%)

Query: 285 ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 344
           AD   L DPF  V F  +  CT ++ +   P W+Q++   NL++     +       I +
Sbjct: 389 ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV---NLQI-----KFPSVCEKIKL 440

Query: 345 EIYDQDSMGKADFMGRTF 362
            IYD D + K D +G T+
Sbjct: 441 TIYDWDRLTKNDVVGTTY 458



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 25/97 (25%), Positives = 46/97 (47%), Gaps = 8/97 (8%)

Query: 817 ADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPME-SMLTVAVYDWD 875
           AD     DP++ +      +    N I K  NP + +  +++  FP     + + +YDWD
Sbjct: 389 ADKKNLVDPFVEVSFAGKKVCT--NIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWD 446

Query: 876 LVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 912
            +  +D++G T + L     SK  A+ G  + +S+ G
Sbjct: 447 RLTKNDVVGTTYLHL-----SKIAASGGEVEDFSSSG 478



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 796 SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 855
           SN P +  +RV V+    L   +I      ++  +  +T I+   N    +L   F  + 
Sbjct: 193 SNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDEL---FFYNV 249

Query: 856 DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDL 890
           ++  S  M+ ++++ VY+   +  D L+GE KID+
Sbjct: 250 NMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV 284


>gi|116642865 fer-1-like 5 isoform 1 [Homo sapiens]
          Length = 802

 Score =  429 bits (1102), Expect = e-119
 Identities = 244/602 (40%), Positives = 351/602 (58%), Gaps = 45/602 (7%)

Query: 718  LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 775
            LKVY  ELE+   F   +D+  TF L + +   D         +VG FKG   +Y  P P
Sbjct: 156  LKVYECELEAVPAFQGLQDFCQTFKLYQEQPKLDSP-------VVGEFKGLFRIY--PFP 206

Query: 776  EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 835
            E+   EA       +      + P   LVRVY+VRA +L P D NG  DPY+ ++LGKT+
Sbjct: 207  ENP--EAPKPPLQFLVWPEREDFPQPCLVRVYMVRAINLQPQDYNGLCDPYVILKLGKTE 264

Query: 836  IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 895
            + +++ Y    L+P+FG  F++  + P+E  L + +YD+DL   DD IG T IDLENR  
Sbjct: 265  LGNRDMYQPNTLDPIFGMMFELTCNIPLEKDLEIQLYDFDLFSPDDKIGTTVIDLENRLL 324

Query: 896  SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 955
            S   A CG++++Y   G   WRD M PS +L R  K   +  P F P       + VF  
Sbjct: 325  SGFGAHCGLSKSYCQSGPFRWRDQMPPSYLLERYAKRKGLPPPLFSPE-----EDAVFYN 379

Query: 956  PSEIEDENGQRK--------PTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKP 1007
              + + ++ + K        P  E +AL  L H +        LVPEHVETR L +  +P
Sbjct: 380  GKKFKLQSFEPKTPTVHGLGPKKERLALYLL-HTQG-------LVPEHVETRTLYSHSQP 431

Query: 1008 GIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKS 1067
            GI+QG++++WVD+FP  +  PG  ++I+PRKPK+YELR IIW T  V L DD+  + EK+
Sbjct: 432  GIDQGKVQMWVDIFPKKLGPPGPQVNINPRKPKRYELRCIIWKTANVDLVDDNL-SREKT 490

Query: 1068 SDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSW 1127
            SDI+++GWL G ++D Q TD+HYHSLTGE +FNWR++F  DYLAAE   V S+K+ ++S 
Sbjct: 491  SDIYIKGWLYGLEKDMQKTDIHYHSLTGEADFNWRFIFTMDYLAAERTCVQSQKDYIWSL 550

Query: 1128 DETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPL 1187
            D T  K PARL +Q+WD D FS DDFLG +ELDL+  P  A+ AKQC++ M   +   P 
Sbjct: 551  DATSMKFPARLIIQVWDNDIFSPDDFLGVLELDLSDMPLPARHAKQCSIRMMDADPKWPY 610

Query: 1188 ------VSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEP 1241
                   S+FK+K V GWWP     +  ++ L+GKV+  L +L+ +EA   P G  ++EP
Sbjct: 611  FIQYKHFSLFKKKTVTGWWPCQVL-DGGKWRLSGKVKMSLEILSEKEALIKPAGRGQSEP 669

Query: 1242 D---PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPG 1298
            +    L  P R +TSF W  +P+++  Y  W  YR+ L+  +++ ++ L+L  F+YS P 
Sbjct: 670  NQYPTLHPPLRTNTSFTWLRSPVQNFCYIFWKRYRFKLIAFMVISIIALMLFNFIYSAPH 729

Query: 1299 YL 1300
            YL
Sbjct: 730  YL 731



 Score = 38.5 bits (88), Expect = 0.043
 Identities = 23/86 (26%), Positives = 44/86 (51%), Gaps = 2/86 (2%)

Query: 460 LAQVDRPRVDIECAGKGVQSSLIHNYKKNPNF--NTLVKWFEVDLPENELLHPPLNIRVV 517
           + +   P++ +E   + +++  I +++ NPNF  +  V    V +P  E    PL ++VV
Sbjct: 1   MKKASSPQLLVEFGEESLRTEPIRDFQTNPNFPESESVLVLTVLMPTEEAYALPLVVKVV 60

Query: 518 DCRAFGRYTLVGSHAVSSLRRFIYRP 543
           D  AFG+ T+ G   +  L+ +   P
Sbjct: 61  DNWAFGQQTVTGQANIDFLQPYFCDP 86


>gi|164607133 fer-1-like 5 isoform 2 [Homo sapiens]
          Length = 2093

 Score =  421 bits (1082), Expect = e-117
 Identities = 244/611 (39%), Positives = 351/611 (57%), Gaps = 54/611 (8%)

Query: 718  LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 775
            LKVY  ELE+   F   +D+  TF L + +   D         +VG FKG   +Y  P P
Sbjct: 1438 LKVYECELEAVPAFQGLQDFCQTFKLYQEQPKLDSP-------VVGEFKGLFRIY--PFP 1488

Query: 776  EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 835
            E+   EA       +      + P   LVRVY+VRA +L P D NG  DPY+ ++LGKT+
Sbjct: 1489 ENP--EAPKPPLQFLVWPEREDFPQPCLVRVYMVRAINLQPQDYNGLCDPYVILKLGKTE 1546

Query: 836  IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 895
            + +++ Y    L+P+FG  F++  + P+E  L + +YD+DL   DD IG T IDLENR  
Sbjct: 1547 LGNRDMYQPNTLDPIFGMMFELTCNIPLEKDLEIQLYDFDLFSPDDKIGTTVIDLENRLL 1606

Query: 896  SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 955
            S   A CG++++Y   G   WRD M PS +L R  K   +  P F P       + VF  
Sbjct: 1607 SGFGAHCGLSKSYCQSGPFRWRDQMPPSYLLERYAKRKGLPPPLFSPE-----EDAVFYN 1661

Query: 956  PSEIEDENGQRK--------PTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKP 1007
              + + ++ + K        P  E +AL  L H +        LVPEHVETR L +  +P
Sbjct: 1662 GKKFKLQSFEPKTPTVHGLGPKKERLALYLL-HTQG-------LVPEHVETRTLYSHSQP 1713

Query: 1008 GIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKK---------YELRVIIWNTDEVVLED 1058
            GI+QG++++WVD+FP  +  PG  ++I+PRKPK+         YELR IIW T  V L D
Sbjct: 1714 GIDQGKVQMWVDIFPKKLGPPGPQVNINPRKPKRKASEHSGHRYELRCIIWKTANVDLVD 1773

Query: 1059 DDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVI 1118
            D+  + EK+SDI+++GWL G ++D Q TD+HYHSLTGE +FNWR++F  DYLAAE   V 
Sbjct: 1774 DNL-SREKTSDIYIKGWLYGLEKDMQKTDIHYHSLTGEADFNWRFIFTMDYLAAERTCVQ 1832

Query: 1119 SKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEM 1178
            S+K+ ++S D T  K PARL +Q+WD D FS DDFLG +ELDL+  P  A+ AKQC++ M
Sbjct: 1833 SQKDYIWSLDATSMKFPARLIIQVWDNDIFSPDDFLGVLELDLSDMPLPARHAKQCSIRM 1892

Query: 1179 ATGEVDVPL------VSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKN 1232
               +   P        S+FK+K V GWWP     +  ++ L+GKV+  L +L+ +EA   
Sbjct: 1893 MDADPKWPYFIQYKHFSLFKKKTVTGWWPCQVL-DGGKWRLSGKVKMSLEILSEKEALIK 1951

Query: 1233 PVGLARNEPD---PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLL 1289
            P G  ++EP+    L  P R +TSF W  +P+++  Y  W  YR+ L+  +++ ++ L+L
Sbjct: 1952 PAGRGQSEPNQYPTLHPPLRTNTSFTWLRSPVQNFCYIFWKRYRFKLIAFMVISIIALML 2011

Query: 1290 ALFLYSVPGYL 1300
              F+YS P YL
Sbjct: 2012 FNFIYSAPHYL 2022



 Score =  143 bits (361), Expect = 9e-34
 Identities = 100/339 (29%), Positives = 170/339 (50%), Gaps = 21/339 (6%)

Query: 210  GSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQA 269
            G   W VQA ++L    G  +  K +  GL   F++ +  Q       P +   + K   
Sbjct: 1046 GRLSW-VQA-MDLKYHAGKEEDSKTWPWGLDRQFRDPQR-QDTRPPNLPFIYCTFNKPHY 1102

Query: 270  FQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELY 329
            +QL  ++YQAR+L +        PF RV F+N SQCT+ L  +  PTW Q L+F +L LY
Sbjct: 1103 YQLFCYIYQARNLVSNQILTFQGPFIRVVFLNHSQCTQTLRSSAGPTWAQTLIFQHLLLY 1162

Query: 330  GEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLV--KMADEAYCPPRFPPQLEYYQ 387
                + ++ PP++V+E++ +D  GK    GR+   P+V   + D    P R+ P ++   
Sbjct: 1163 ENPQDTKESPPLVVLELWQRDFWGKESLWGRSVWPPMVWLDLQDRILPPMRWHPLVKEL- 1221

Query: 388  IYRGNATAGDLLAAFEL-LQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVE 446
                    G++LA+ EL LQ    G+  LP ++ P    +     +P  I+P + +  +E
Sbjct: 1222 ----GKEEGEILASCELILQTEKLGEKQLPILSVPW---KNGAYTLPKSIQPTIKRMAIE 1274

Query: 447  VLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNF--NTLVKWFEVDLPE 504
            +L WGLR++K+ +      P++ +E   + +++  I +++ NPNF  +  V    V +P 
Sbjct: 1275 ILAWGLRNMKKAS-----SPQLLVEFGEESLRTEPIRDFQTNPNFPESESVLVLTVLMPT 1329

Query: 505  NELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRP 543
             E    PL ++VVD  AFG+ T+ G   +  L+ +   P
Sbjct: 1330 EEAYALPLVVKVVDNWAFGQQTVTGQANIDFLQPYFCDP 1368



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 41/131 (31%), Positives = 73/131 (55%), Gaps = 11/131 (8%)

Query: 98  TRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIP 157
           T LDR+R +     L+ + Q+A+  +        +D +   +++L +L  +  EPQ  +P
Sbjct: 640 TSLDRKRWQLRSLLLQELAQKAKQAKP-------KDMVATAEDWLYRLNTVLPEPQMGLP 692

Query: 158 DIFIWMMSNNKRVAYARVPSKDLLFSIVEE-ETGKDCAKVKTLFLKLPGKRGFGSAGWTV 216
           D+ IW+++  +RVAYA+VP+  +LFS      +G+ C K++TLFL+ P   G       +
Sbjct: 693 DVMIWLVAKEQRVAYAQVPAHSVLFSPAGALHSGRLCGKIQTLFLQYPEGEGQKD---VL 749

Query: 217 QAKVELYLWLG 227
            A + + +WLG
Sbjct: 750 PAHLRVCMWLG 760


>gi|4759026 RAS protein activator like 1 [Homo sapiens]
          Length = 804

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 37/94 (39%), Positives = 51/94 (54%), Gaps = 9/94 (9%)

Query: 272 LRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGE 331
           LR H+  AR L   D SG SDPFARVF+ +QS  T  + +T  P WD++L         E
Sbjct: 135 LRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVL---------E 185

Query: 332 AHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKP 365
             E+   P  + +E++D D +GK DF+G     P
Sbjct: 186 LREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSP 219



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 25/81 (30%), Positives = 44/81 (54%), Gaps = 2/81 (2%)

Query: 804 VRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPM 863
           +R +V+ A DL P DI+G +DP+  +  G   +  + + I K   P + +  ++      
Sbjct: 135 LRCHVLHARDLAPRDISGTSDPFARVFWGSQSL--ETSTIKKTRFPHWDEVLELREMPGA 192

Query: 864 ESMLTVAVYDWDLVGTDDLIG 884
            S L V ++DWD+VG +D +G
Sbjct: 193 PSPLRVELWDWDMVGKNDFLG 213



 Score = 39.7 bits (91), Expect = 0.019
 Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 2/88 (2%)

Query: 804 VRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPM 863
           + V VV    L   D++G +DPY  +++   ++  +   + + L P +G+ + +      
Sbjct: 7   LNVRVVEGRALPAKDVSGSSDPYCLVKVDD-EVVARTATVWRSLGPFWGEEYTVHLPLDF 65

Query: 864 ESMLTVAVYDWDLVGTDDLIGETKIDLE 891
              L   V D D VG DD+IG+  +  E
Sbjct: 66  HQ-LAFYVLDEDTVGHDDIIGKISLSRE 92


>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 2 [Homo sapiens]
          Length = 731

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 804 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 862
           +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 63  LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 119

Query: 863 MESMLTVAVYDWDLVGTDDLIGETKIDLE 891
               L V  +DWDLV  +D +G+  ID++
Sbjct: 120 AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 148



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 263 VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 322
           V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 54  VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 113

Query: 323 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 360
           F+  E   EA         + +E +D D + + DF+G+
Sbjct: 114 FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 142



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1109 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1163
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 90   YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 149


>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 1 [Homo sapiens]
          Length = 757

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 804 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 862
           +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 191

Query: 863 MESMLTVAVYDWDLVGTDDLIGETKIDLE 891
               L V  +DWDLV  +D +G+  ID++
Sbjct: 192 AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 220



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 263 VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 322
           V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 126 VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185

Query: 323 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 360
           F+  E   EA         + +E +D D + + DF+G+
Sbjct: 186 FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 214



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1109 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1163
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 162  YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 221


>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 1 [Homo sapiens]
          Length = 731

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 804 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 862
           +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 63  LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 119

Query: 863 MESMLTVAVYDWDLVGTDDLIGETKIDLE 891
               L V  +DWDLV  +D +G+  ID++
Sbjct: 120 AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 148



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 263 VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 322
           V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 54  VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 113

Query: 323 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 360
           F+  E   EA         + +E +D D + + DF+G+
Sbjct: 114 FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 142



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1109 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1163
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 90   YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 149


>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 2 [Homo sapiens]
          Length = 757

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 804 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 862
           +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 191

Query: 863 MESMLTVAVYDWDLVGTDDLIGETKIDLE 891
               L V  +DWDLV  +D +G+  ID++
Sbjct: 192 AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 220



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 263 VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 322
           V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 126 VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185

Query: 323 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 360
           F+  E   EA         + +E +D D + + DF+G+
Sbjct: 186 FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 214



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1109 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1163
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 162  YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 221


>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
          Length = 757

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 804 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 862
           +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 191

Query: 863 MESMLTVAVYDWDLVGTDDLIGETKIDLE 891
               L V  +DWDLV  +D +G+  ID++
Sbjct: 192 AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 220



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 263 VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 322
           V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 126 VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185

Query: 323 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 360
           F+  E   EA         + +E +D D + + DF+G+
Sbjct: 186 FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 214



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1109 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1163
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 162  YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 221


>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
          Length = 803

 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 804 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 862
           +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 191

Query: 863 MESMLTVAVYDWDLVGTDDLIGETKIDLE 891
               L V  +DWDLV  +D +G+  ID++
Sbjct: 192 AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 220



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 263 VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 322
           V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 126 VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185

Query: 323 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 360
           F+  E   EA         + +E +D D + + DF+G+
Sbjct: 186 FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 214



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1109 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1163
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 162  YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 221


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,602,489
Number of Sequences: 37866
Number of extensions: 2754846
Number of successful extensions: 16605
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 455
Number of HSP's that attempted gapping in prelim test: 12022
Number of HSP's gapped (non-prelim): 2970
length of query: 1307
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1193
effective length of database: 13,930,794
effective search space: 16619437242
effective search space used: 16619437242
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.