Search of human proteins with 34740331

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|34740331 otoferlin isoform a [Homo sapiens]
         (1997 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|34740331 otoferlin isoform a [Homo sapiens]                       4061   0.0  
gi|35493853 otoferlin isoform c [Homo sapiens]                       2577   0.0  
gi|35493868 otoferlin isoform b [Homo sapiens]                       2503   0.0  
gi|35493860 otoferlin isoform d [Homo sapiens]                       2470   0.0  
gi|119120884 fer-1-like 6 [Homo sapiens]                             1803   0.0  
gi|195976779 dysferlin isoform 1 [Homo sapiens]                       723   0.0  
gi|195976773 dysferlin isoform 5 [Homo sapiens]                       723   0.0  
gi|195976769 dysferlin isoform 6 [Homo sapiens]                       723   0.0  
gi|195976764 dysferlin isoform 14 [Homo sapiens]                      723   0.0  
gi|195976758 dysferlin isoform 11 [Homo sapiens]                      723   0.0  
gi|195976756 dysferlin isoform 10 [Homo sapiens]                      723   0.0  
gi|195976821 dysferlin isoform 2 [Homo sapiens]                       712   0.0  
gi|4503431 dysferlin isoform 8 [Homo sapiens]                         712   0.0  
gi|195976777 dysferlin isoform 3 [Homo sapiens]                       712   0.0  
gi|195976775 dysferlin isoform 4 [Homo sapiens]                       712   0.0  
gi|195976766 dysferlin isoform 7 [Homo sapiens]                       712   0.0  
gi|195976762 dysferlin isoform 13 [Homo sapiens]                      712   0.0  
gi|195976760 dysferlin isoform 12 [Homo sapiens]                      712   0.0  
gi|195976754 dysferlin isoform 9 [Homo sapiens]                       712   0.0  
gi|19718759 myoferlin isoform b [Homo sapiens]                        684   0.0  
gi|7305053 myoferlin isoform a [Homo sapiens]                         684   0.0  
gi|116642865 fer-1-like 5 isoform 1 [Homo sapiens]                    429   e-119
gi|164607133 fer-1-like 5 isoform 2 [Homo sapiens]                    421   e-117
gi|4759026 RAS protein activator like 1 [Homo sapiens]                 66   3e-10
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva...    55   9e-07
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva...    55   9e-07
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva...    55   9e-07
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva...    55   9e-07
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]      55   9e-07
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]      55   9e-07

>gi|34740331 otoferlin isoform a [Homo sapiens]
          Length = 1997

 Score = 4061 bits (10533), Expect = 0.0
 Identities = 1997/1997 (100%), Positives = 1997/1997 (100%)

Query: 1    MALLIHLKTVSELRGRGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNE 60
            MALLIHLKTVSELRGRGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNE
Sbjct: 1    MALLIHLKTVSELRGRGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNE 60

Query: 61   MLEIQVFNYSKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQA 120
            MLEIQVFNYSKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQA
Sbjct: 61   MLEIQVFNYSKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQA 120

Query: 121  TDGTVGSWDDGDFLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMK 180
            TDGTVGSWDDGDFLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMK
Sbjct: 121  TDGTVGSWDDGDFLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMK 180

Query: 181  LGKNRSHKEEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKP 240
            LGKNRSHKEEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKP
Sbjct: 181  LGKNRSHKEEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKP 240

Query: 241  DIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEY 300
            DIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEY
Sbjct: 241  DIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEY 300

Query: 301  FVFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILS 360
            FVFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILS
Sbjct: 301  FVFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILS 360

Query: 361  DPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFY 420
            DPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFY
Sbjct: 361  DPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFY 420

Query: 421  VKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNE 480
            VKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNE
Sbjct: 421  VKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNE 480

Query: 481  QVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMY 540
            QVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMY
Sbjct: 481  QVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMY 540

Query: 541  GSTRNYTLLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSNPELTSSTEVQVEQATPIS 600
            GSTRNYTLLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSNPELTSSTEVQVEQATPIS
Sbjct: 541  GSTRNYTLLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSNPELTSSTEVQVEQATPIS 600

Query: 601  ESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDGLSRPQRPRPRKEPG 660
            ESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDGLSRPQRPRPRKEPG
Sbjct: 601  ESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDGLSRPQRPRPRKEPG 660

Query: 661  DEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKPCIYIKSWWPD 720
            DEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKPCIYIKSWWPD
Sbjct: 661  DEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKPCIYIKSWWPD 720

Query: 721  QRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADK 780
            QRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADK
Sbjct: 721  QRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADK 780

Query: 781  DQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLAD 840
            DQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLAD
Sbjct: 781  DQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLAD 840

Query: 841  EPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFG 900
            EPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFG
Sbjct: 841  EPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFG 900

Query: 901  SAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAF 960
            SAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAF
Sbjct: 901  SAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAF 960

Query: 961  QLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYG 1020
            QLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYG
Sbjct: 961  QLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYG 1020

Query: 1021 EAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYR 1080
            EAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYR
Sbjct: 1021 EAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYR 1080

Query: 1081 GNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFW 1140
            GNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFW
Sbjct: 1081 GNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFW 1140

Query: 1141 GLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHP 1200
            GLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHP
Sbjct: 1141 GLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHP 1200

Query: 1201 PLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSS 1260
            PLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSS
Sbjct: 1201 PLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSS 1260

Query: 1261 SHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEE 1320
            SHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEE
Sbjct: 1261 SHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEE 1320

Query: 1321 PDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKE 1380
            PDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKE
Sbjct: 1321 PDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKE 1380

Query: 1381 EKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDE 1440
            EKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDE
Sbjct: 1381 EKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDE 1440

Query: 1441 DGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVR 1500
            DGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVR
Sbjct: 1441 DGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVR 1500

Query: 1501 ATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVA 1560
            ATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVA
Sbjct: 1501 ATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVA 1560

Query: 1561 VYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLC 1620
            VYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLC
Sbjct: 1561 VYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLC 1620

Query: 1621 KDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCR 1680
            KDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCR
Sbjct: 1621 KDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCR 1680

Query: 1681 LVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWN 1740
            LVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWN
Sbjct: 1681 LVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWN 1740

Query: 1741 TDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYL 1800
            TDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYL
Sbjct: 1741 TDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYL 1800

Query: 1801 AAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKT 1860
            AAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKT
Sbjct: 1801 AAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKT 1860

Query: 1861 AKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAE 1920
            AKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAE
Sbjct: 1861 AKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAE 1920

Query: 1921 KNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLA 1980
            KNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLA
Sbjct: 1921 KNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLA 1980

Query: 1981 LFLYSVPGYLVKKILGA 1997
            LFLYSVPGYLVKKILGA
Sbjct: 1981 LFLYSVPGYLVKKILGA 1997


>gi|35493853 otoferlin isoform c [Homo sapiens]
          Length = 1307

 Score = 2577 bits (6680), Expect = 0.0
 Identities = 1261/1265 (99%), Positives = 1261/1265 (99%)

Query: 733  HIADKLEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDR 792
            H  D  EEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDR
Sbjct: 43   HTPDSQEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDR 102

Query: 793  ERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIW 852
            ERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIW
Sbjct: 103  ERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIW 162

Query: 853  MMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVEL 912
            MMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVEL
Sbjct: 163  MMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVEL 222

Query: 913  YLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSL 972
            YLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSL
Sbjct: 223  YLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSL 282

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPII 1032
            FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPII
Sbjct: 283  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPII 342

Query: 1033 VIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAF 1092
            VIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAF
Sbjct: 343  VIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAF 402

Query: 1093 ELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQ 1152
            ELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQ
Sbjct: 403  ELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQ 462

Query: 1153 VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAF 1212
            VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAF
Sbjct: 463  VDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAF 522

Query: 1213 GRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTME 1272
            GRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTME
Sbjct: 523  GRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTME 582

Query: 1273 PEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKY 1332
            PEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKY
Sbjct: 583  PEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKY 642

Query: 1333 FASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSG 1392
            FASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSG
Sbjct: 643  FASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSG 702

Query: 1393 QGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGR 1452
            QGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGR
Sbjct: 703  QGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGR 762

Query: 1453 FKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGK 1512
            FKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGK
Sbjct: 763  FKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGK 822

Query: 1513 ADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDL 1572
            ADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDL
Sbjct: 823  ADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDL 882

Query: 1573 IGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGP 1632
            IGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGP
Sbjct: 883  IGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGP 942

Query: 1633 PGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLL 1692
            PGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLL
Sbjct: 943  PGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLL 1002

Query: 1693 NPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFF 1752
            NPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFF
Sbjct: 1003 NPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFF 1062

Query: 1753 TGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKE 1812
            TGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKE
Sbjct: 1063 TGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKE 1122

Query: 1813 SMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGE 1872
            SMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGE
Sbjct: 1123 SMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGE 1182

Query: 1873 VDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD 1932
            VDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD
Sbjct: 1183 VDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD 1242

Query: 1933 PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVK 1992
            PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVK
Sbjct: 1243 PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVK 1302

Query: 1993 KILGA 1997
            KILGA
Sbjct: 1303 KILGA 1307



 Score = 36.6 bits (83), Expect = 0.25
 Identities = 16/51 (31%), Positives = 26/51 (50%)

Query: 437 MANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
           M   +  F  ++  L DP+ +VFF  Q   T V   +  P W++ +VF +L
Sbjct: 276 MYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNL 326


>gi|35493868 otoferlin isoform b [Homo sapiens]
          Length = 1230

 Score = 2503 bits (6488), Expect = 0.0
 Identities = 1230/1250 (98%), Positives = 1230/1250 (98%), Gaps = 20/1250 (1%)

Query: 748  MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 807
            MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ
Sbjct: 1    MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 60

Query: 808  QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 867
            QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS
Sbjct: 61   QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 120

Query: 868  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 927
            KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC
Sbjct: 121  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 180

Query: 928  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 987
            GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV
Sbjct: 181  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 240

Query: 988  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 1047
            FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF
Sbjct: 241  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 300

Query: 1048 MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 1107
            MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP
Sbjct: 301  MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 360

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
            INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV
Sbjct: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR
Sbjct: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 1287
            RFIYRPPDRSAPSWNTT                    GEVVVTMEPEVPIKKLETMVKLD
Sbjct: 481  RFIYRPPDRSAPSWNTT--------------------GEVVVTMEPEVPIKKLETMVKLD 520

Query: 1288 ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 1347
            ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE
Sbjct: 521  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 580

Query: 1348 PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 1407
            PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE
Sbjct: 581  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 640

Query: 1408 LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED 1467
            LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED
Sbjct: 641  LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED 700

Query: 1468 VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR 1527
            VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR
Sbjct: 701  VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR 760

Query: 1528 DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK 1587
            DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK
Sbjct: 761  DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK 820

Query: 1588 HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS 1647
            HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS
Sbjct: 821  HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS 880

Query: 1648 EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW 1707
            EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW
Sbjct: 881  EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW 940

Query: 1708 VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK 1767
            VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK
Sbjct: 941  VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK 1000

Query: 1768 GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR 1827
            GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR
Sbjct: 1001 GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR 1060

Query: 1828 LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK 1887
            LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK
Sbjct: 1061 LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK 1120

Query: 1888 GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWF 1947
            GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWF
Sbjct: 1121 GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWF 1180

Query: 1948 LNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA 1997
            LNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA
Sbjct: 1181 LNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA 1230



 Score = 36.6 bits (83), Expect = 0.25
 Identities = 16/51 (31%), Positives = 26/51 (50%)

Query: 437 MANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
           M   +  F  ++  L DP+ +VFF  Q   T V   +  P W++ +VF +L
Sbjct: 219 MYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNL 269


>gi|35493860 otoferlin isoform d [Homo sapiens]
          Length = 1230

 Score = 2470 bits (6401), Expect = 0.0
 Identities = 1209/1250 (96%), Positives = 1222/1250 (97%), Gaps = 20/1250 (1%)

Query: 748  MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 807
            MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ
Sbjct: 1    MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 60

Query: 808  QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 867
            QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS
Sbjct: 61   QARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPS 120

Query: 868  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 927
            KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC
Sbjct: 121  KDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC 180

Query: 928  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 987
            GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV
Sbjct: 181  GLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARV 240

Query: 988  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 1047
            FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF
Sbjct: 241  FFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADF 300

Query: 1048 MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 1107
            MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP
Sbjct: 301  MGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPP 360

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
            INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV
Sbjct: 361  INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 420

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR
Sbjct: 421  QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 480

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 1287
            RFIYRPPDRSAPSWNTT                    GEVVVTMEPEVPIKKLETMVKLD
Sbjct: 481  RFIYRPPDRSAPSWNTT--------------------GEVVVTMEPEVPIKKLETMVKLD 520

Query: 1288 ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 1347
            ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE
Sbjct: 521  ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 580

Query: 1348 PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 1407
            PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE
Sbjct: 581  PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 640

Query: 1408 LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED 1467
            LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED
Sbjct: 641  LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPED 700

Query: 1468 VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR 1527
            VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR
Sbjct: 701  VSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIR 760

Query: 1528 DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK 1587
            DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK
Sbjct: 761  DKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSK 820

Query: 1588 HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS 1647
            HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS
Sbjct: 821  HRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPS 880

Query: 1648 EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW 1707
            EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW
Sbjct: 881  EIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELW 940

Query: 1708 VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK 1767
            VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK
Sbjct: 941  VDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLK 1000

Query: 1768 GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR 1827
            GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR
Sbjct: 1001 GQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPAR 1060

Query: 1828 LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK 1887
            LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK
Sbjct: 1061 LTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVK 1120

Query: 1888 GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWF 1947
            GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDT+F+WF
Sbjct: 1121 GWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWF 1180

Query: 1948 LNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA 1997
            LNPLKS +Y +   Y+WL++K++L LL LL+L LFLYS+PGY+VKK+LGA
Sbjct: 1181 LNPLKSIKYLICTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLLGA 1230



 Score = 36.6 bits (83), Expect = 0.25
 Identities = 16/51 (31%), Positives = 26/51 (50%)

Query: 437 MANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
           M   +  F  ++  L DP+ +VFF  Q   T V   +  P W++ +VF +L
Sbjct: 219 MYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNL 269


>gi|119120884 fer-1-like 6 [Homo sapiens]
          Length = 1857

 Score = 1803 bits (4670), Expect = 0.0
 Identities = 921/1857 (49%), Positives = 1279/1857 (68%), Gaps = 140/1857 (7%)

Query: 224  ASVTALTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDK 283
            AS+  + +    +RSK   K+     R  +YQ++IT+ EARQLVG N+DPVV +E+GD+K
Sbjct: 53   ASIFPVPSASPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVTIEIGDEK 112

Query: 284  KYTSMKESTNCPYYNEYFVFDFHVSPDV-MFDKIIKISVIHSKNLLRSGTLVGSFKMDVG 342
            K +++KE TN P+YNEYFVFDF + P V +FDKIIKISV H K  L    L+GSFK+D+G
Sbjct: 113  KQSTVKEGTNSPFYNEYFVFDF-IGPQVHLFDKIIKISVFHHK--LIGSVLIGSFKVDLG 169

Query: 343  TVYSQPEHQFHHKWAILSDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEG 402
            TVY+QP HQF +KWA+L+DP DI +G KGY+KCD++V+GKGD +KT  K ++T+E  IE 
Sbjct: 170  TVYNQPGHQFCNKWALLTDPGDIRTGTKGYLKCDISVMGKGDVLKTSPKTSDTEEP-IEK 228

Query: 403  NLLLPEGVPPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAG 462
            NLL+P G P ER WARFYV++Y+AEGLP+MN+S+MANV KAF+G++KDLVDP+V+V FAG
Sbjct: 229  NLLIPNGFPLERPWARFYVRLYKAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAG 288

Query: 463  QKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISN 522
            Q G+T+VQK+  +P+W+EQV+F ++FPPLC+R+K+Q+ D   +NDVA+ THFIDL+KISN
Sbjct: 289  QMGRTTVQKNCADPVWHEQVIFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISN 348

Query: 523  --DGDKGFLPTLGPAWVNMYGSTRNYTLLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDT 580
              DGDKGFLPT GPAW+N+YGS RN++L+D++Q++NEG GEGVSFR R+L+ +AVEI+  
Sbjct: 349  EQDGDKGFLPTFGPAWINLYGSPRNHSLMDDYQEMNEGFGEGVSFRGRILVEIAVEILSG 408

Query: 581  SNPEL-----------------------------------------TSSTEVQVEQATPI 599
               E                                          T+STEV+VE     
Sbjct: 409  RAQESKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVP 468

Query: 600  SESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDGLSRPQRPRPRKEP 659
             E    K EEF LFGAF EA+MIDR+ GDKPI+FEV+IGN+GN +DG S     +   E 
Sbjct: 469  PEIVPEKNEEFLLFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSH-HGSKKSAES 527

Query: 660  GDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTD--RNYFHLPYLERKPCIYIKSW 717
             +E+ + L+     D A D   +   S+T P +P VT+  RNY +LP+  +KPC+Y  S 
Sbjct: 528  AEEDLLPLLHEGQGDVAHDV-PIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISS 586

Query: 718  WPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSL 777
            W DQ  RL+ +N+++ +AD LEE + +++E+IK  +  PE +++ VL +       F+S 
Sbjct: 587  WGDQTFRLHWSNMLEKMADFLEESIEEVRELIKISQEAPEEKMKTVLSDFISRSSAFISE 646

Query: 778  ADKDQGHSSRTRLDRERLKSCMRELENMGQQAR-MLRAQVKRHTVRDKLRLCQNFLQKLR 836
            A+K     ++T LD++RL  C +ELE M ++A+ +++ Q K+ +V + +   QNF++K+R
Sbjct: 647  AEKKPKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIR 706

Query: 837  FLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGK 896
            FL DEPQH+IPD+FIWM+SNN+RVAYAR+ SKDLL+S V  + GK C K+KT FLK PGK
Sbjct: 707  FLVDEPQHTIPDVFIWMLSNNRRVAYARIASKDLLYSPVAGQMGKHCGKIKTHFLKPPGK 766

Query: 897  RGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTK 956
            R    AGW+VQAKV++YLWLG  K     L  LP G++   +++G G +  PP +L+Y +
Sbjct: 767  R---PAGWSVQAKVDVYLWLGSIKHASAILDNLPVGYEAEMSSKGAGTN-HPPSNLLYQE 822

Query: 957  KQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNL 1016
            +  FQLRAHMYQAR L AADS+GLSDPFA+V F++  Q T+++++TL PTW+QML+F++L
Sbjct: 823  QHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDL 882

Query: 1017 ELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYY 1076
             L+G+  EL + PP++V+E+YD D++GK +++G T A P+VK+AD+ Y PPR    L Y+
Sbjct: 883  VLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPR----LCYH 938

Query: 1077 QIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVE 1136
             I+ GN + GDLLA FELLQ+ P+G   LPP+  P   D   I PVP  IRPVLSKYRVE
Sbjct: 939  PIFCGNLSGGDLLAVFELLQVPPSGLQGLPPVEPP---DITQIYPVPANIRPVLSKYRVE 995

Query: 1137 VLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENE 1196
            VLFWG+R++K+V L  VDRP+  IEC G+GV+S +I +YK NPNF+     FEV+LPENE
Sbjct: 996  VLFWGVREMKKVQLLSVDRPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENE 1055

Query: 1197 LLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCN 1256
            LLHPPL+I VVD RAFGR TLVG++ ++ L++F+ +  +  AP   T V   +    + +
Sbjct: 1056 LLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKLREPLAPI--TQVDGTQPGHDISD 1113

Query: 1257 GGSSSHSTGEVVVTMEPE-----VPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKG 1311
              +++ S+G    + +P      V ++   T+V   A ++  + VDV +     + +   
Sbjct: 1114 SLTATESSGAHSSSQDPPADHIYVDVEPPPTVVPDSAQAQPAILVDVPDSSPMLEPEHTP 1173

Query: 1312 TAEEPEEE-----------------------EPDESMLDWWSKYFASIDTMKEQLRQQEP 1348
             A+EP ++                       E  E+++DWWSKY+AS+            
Sbjct: 1174 VAQEPPKDGKPKDPRKPSRRSTKRRKRTIADESAENVIDWWSKYYASLKKA--------- 1224

Query: 1349 SGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEE---KKKKTQSSGSGQGSEAPEKKKPKI 1405
                  +K +  N +G KG+ + K        E   KKKK +            KKKPK 
Sbjct: 1225 ------QKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDKML----------KKKPKD 1268

Query: 1406 DE------LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCV 1459
            D       L++Y  +LESEF+NFEDW+ TF L RGK+ +D+ G  + +R++G+FKGS C+
Sbjct: 1269 DGIPNLAILQIYDGDLESEFNNFEDWVKTFELFRGKSTEDDHG-LDGDRVIGKFKGSFCI 1327

Query: 1460 YKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAI 1519
            YK P  +D S E        + QGIP N P+ VL+RVY+V A +L PAD +GK+DPYI I
Sbjct: 1328 YKSP--QDSSSEDS--GQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVI 1383

Query: 1520 RLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKID 1579
            +LGKT+I+D++ YI KQLNPVFG+SF+I+A+FP ES+L++ +YD D++GTDDLIGETKID
Sbjct: 1384 KLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETKID 1443

Query: 1580 LENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVA 1639
            LENRFYSKHRA CG+   Y   GYN WRD  KP++ILT+LCKD K+DGP+F P G++++ 
Sbjct: 1444 LENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHP-GKIQIG 1502

Query: 1640 NRVFTGPSEI-EDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPG 1698
            N+VF+G +   E++  +   + EH+AL  L  WEDIP  GCRLVPEH+ETRPL + DKPG
Sbjct: 1503 NQVFSGKTIFTEEDTDETVESYEHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDKPG 1562

Query: 1699 IEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSS 1758
            +EQGRL++WVDMFP DMP PG P+DISPR+PK YELRV IWNT++V+LED++ FTG+KSS
Sbjct: 1563 MEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQKSS 1622

Query: 1759 DIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWD 1818
            DI+V+GWLKG ++DKQ+TDVHY+SLTGEGNFNWR+LFPF YL AE+++VI+K+E++FS +
Sbjct: 1623 DIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLE 1682

Query: 1819 ETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLV 1878
            + E K PA L LQ+WD +  S+DDFLG +E++LN FPR AK+AK C +       +   +
Sbjct: 1683 KMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENASEETKI 1742

Query: 1879 SIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPN 1938
            SIF+QKRV+GWWP      +   ELTGKVEAE HL+TAEEAEKNPVG AR EP+PL KPN
Sbjct: 1743 SIFQQKRVRGWWPF-----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPN 1797

Query: 1939 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1995
            RPDTSF WF++P K   Y +W  Y+  ++   +L++L++ L LF+Y++PG + ++I+
Sbjct: 1798 RPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIV 1854


>gi|195976779 dysferlin isoform 1 [Homo sapiens]
          Length = 2119

 Score =  723 bits (1867), Expect = 0.0
 Identities = 418/1084 (38%), Positives = 593/1084 (54%), Gaps = 162/1084 (14%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1158 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1217

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1218 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1270

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 1107
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1271 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1327

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1328 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1384

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1385 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1444

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGS---SSHSTGEVVVT----MEPEVPIKKL 1280
             F+  P    +PS                GG    S  S GE V+      EP +PI+  
Sbjct: 1445 SFLCDPYSAESPS--------------PQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLA 1490

Query: 1281 ETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMK 1340
            + +  L  T+ A                       P     +E  +DWWSK+FASI    
Sbjct: 1491 DGLSSLAPTNTA----------------------SPPSSPHEEEFIDWWSKFFASIG--- 1525

Query: 1341 EQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEK 1400
                ++E  G  LE+                                             
Sbjct: 1526 ----EREKCGSYLEKD-------------------------------------------- 1537

Query: 1401 KKPKIDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLC 1458
                 D LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   
Sbjct: 1538 ----FDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFK 1589

Query: 1459 VYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIA 1518
            +Y  PLPED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI 
Sbjct: 1590 IY--PLPEDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIK 1643

Query: 1519 IRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKI 1578
            I +GK  + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +
Sbjct: 1644 ISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVV 1703

Query: 1579 DLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKV 1638
            DLENR  SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV  
Sbjct: 1704 DLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMF 1762

Query: 1639 ANRVFTGPSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPD 1695
             ++ ++   EIE     N    P +E +AL  L+           LVPEHVE+RPL +P 
Sbjct: 1763 QDKEYS-IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPL 1813

Query: 1696 KPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGE 1755
            +P IEQG+L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGE
Sbjct: 1814 QPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGE 1872

Query: 1756 KSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMF 1815
            K SDI+V+GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +
Sbjct: 1873 KMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFW 1932

Query: 1816 SWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDV 1875
              D+TE KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++        
Sbjct: 1933 RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHP 1992

Query: 1876 P-LVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD-- 1932
               VS+F+QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+  
Sbjct: 1993 EWFVSLFEQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMN 2051

Query: 1933 -PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLV 1991
              LE P RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y  
Sbjct: 2052 PKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAA 2111

Query: 1992 KKIL 1995
             K++
Sbjct: 2112 MKLV 2115



 Score =  401 bits (1031), Expect = e-111
 Identities = 299/944 (31%), Positives = 475/944 (50%), Gaps = 112/944 (11%)

Query: 16  RGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVAS-SIDRNEMLEIQVFNYSKVFS 74
           R D +A +TFRG    ++V++N  +   ++E F W +    +D+   L + V ++  +  
Sbjct: 20  RSDPVASLTFRGVKKRTKVIKNSVNPV-WNEGFEWDLKGIPLDQGSELHVVVKDHETMGR 78

Query: 75  NKLIGTFRMVLQKVVEESHVEVTDT--LIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGD 132
           N+ +G  ++ L++V+    +  +    L+D        SL ++V Y    G V  +    
Sbjct: 79  NRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPT 138

Query: 133 FLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQ 192
            L      E      + D +  G +           R    S+ S   +    S K+ P 
Sbjct: 139 PL------EPSPTLPDLDVVAGGGQS----------RAETWSLLSDSTMDTRYSGKKWPA 182

Query: 193 RPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTT-------------NVSNKRSK 239
             D     + ED        GD  +P         A TT              +  KRS 
Sbjct: 183 PTDTGGEEDTEDQG----LTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSA 238

Query: 240 PDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNE 299
           P  +   S  +P D+Q+ + VIE RQL G+N+ PVV V      K T + +  N P +NE
Sbjct: 239 PTSRKLLS-DKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNE 296

Query: 300 YFVFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAIL 359
              F+   SP  +FD+ I I+V+ S++L R+  L+G F+MDVGT+Y +P H +  KW +L
Sbjct: 297 TLFFNLFDSPGELFDEPIFITVVDSRSL-RTDALLGEFRMDVGTIYREPRHAYLRKWLLL 355

Query: 360 SDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARF 419
           SDPDD S+G +GY+K  + V+G GD      K    D++DIE NLL P GV    + A F
Sbjct: 356 SDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGV--ALRGAHF 413

Query: 420 YVKIYRAEGLPRMNTSLMANVKKAFIGEN--KDLVDPYVQVFFAGQKGKTSVQKSSYEPL 477
            +K++RAE LP+M+ ++M NVK+ F  E+  K+LVDP+V+V FAG+   + + + +  P 
Sbjct: 414 CLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQ 473

Query: 478 WNEQVVFTDLFPPLCKRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDGDK-------GF 528
           WN+ +    +FP +C++M+++I D D++  ND+ + T ++ + KIS  G +       GF
Sbjct: 474 WNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGF 532

Query: 529 LPTLGPAWVNMYGSTRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSN---PE 584
           LPT GP ++N+YGS R +T   D + +LN G GEGV++R RLLL L  ++V+ S     +
Sbjct: 533 LPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVED 592

Query: 585 LTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEV 644
           L +   ++VE+          +  ++ LF AF  A+M+  ++ D  I FEV+IGNYGN+ 
Sbjct: 593 LPADDILRVEKYL--------RRRKYSLFAAFYSATML--QDVDDAIQFEVSIGNYGNKF 642

Query: 645 DGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLP 704
           D    P                                   S+T   R      +Y++LP
Sbjct: 643 DMTCLP---------------------------------LASTTQYSRAVFDGCHYYYLP 669

Query: 705 YLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYP--ERRLRG 762
           +   KP + + S+W D   R+   N +  IAD+LE GL  +   +K + S    +  +  
Sbjct: 670 WGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQ 729

Query: 763 VLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVR 822
           + +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L  ++    + 
Sbjct: 730 LTDELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAA--LALKLGHSELP 784

Query: 823 DKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGK 881
             L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK
Sbjct: 785 AALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGK 844

Query: 882 DCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
           +C K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 845 NCGKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 885



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 1009
            F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 440  FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 476



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 453  DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
            DPY  V F  Q  KT V K++  P W++ ++F ++
Sbjct: 1192 DPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1226


>gi|195976773 dysferlin isoform 5 [Homo sapiens]
          Length = 2088

 Score =  723 bits (1867), Expect = 0.0
 Identities = 418/1084 (38%), Positives = 593/1084 (54%), Gaps = 162/1084 (14%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1127 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1186

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1187 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1239

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 1107
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1240 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1296

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1297 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1353

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1354 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1413

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGS---SSHSTGEVVVT----MEPEVPIKKL 1280
             F+  P    +PS                GG    S  S GE V+      EP +PI+  
Sbjct: 1414 SFLCDPYSAESPS--------------PQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLA 1459

Query: 1281 ETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMK 1340
            + +  L  T+ A                       P     +E  +DWWSK+FASI    
Sbjct: 1460 DGLSSLAPTNTA----------------------SPPSSPHEEEFIDWWSKFFASIG--- 1494

Query: 1341 EQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEK 1400
                ++E  G  LE+                                             
Sbjct: 1495 ----EREKCGSYLEKD-------------------------------------------- 1506

Query: 1401 KKPKIDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLC 1458
                 D LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   
Sbjct: 1507 ----FDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFK 1558

Query: 1459 VYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIA 1518
            +Y  PLPED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI 
Sbjct: 1559 IY--PLPEDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIK 1612

Query: 1519 IRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKI 1578
            I +GK  + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +
Sbjct: 1613 ISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVV 1672

Query: 1579 DLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKV 1638
            DLENR  SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV  
Sbjct: 1673 DLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMF 1731

Query: 1639 ANRVFTGPSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPD 1695
             ++ ++   EIE     N    P +E +AL  L+           LVPEHVE+RPL +P 
Sbjct: 1732 QDKEYS-IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPL 1782

Query: 1696 KPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGE 1755
            +P IEQG+L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGE
Sbjct: 1783 QPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGE 1841

Query: 1756 KSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMF 1815
            K SDI+V+GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +
Sbjct: 1842 KMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFW 1901

Query: 1816 SWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDV 1875
              D+TE KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++        
Sbjct: 1902 RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHP 1961

Query: 1876 P-LVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD-- 1932
               VS+F+QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+  
Sbjct: 1962 EWFVSLFEQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMN 2020

Query: 1933 -PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLV 1991
              LE P RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y  
Sbjct: 2021 PKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAA 2080

Query: 1992 KKIL 1995
             K++
Sbjct: 2081 MKLV 2084



 Score =  396 bits (1018), Expect = e-109
 Identities = 293/931 (31%), Positives = 464/931 (49%), Gaps = 117/931 (12%)

Query: 16  RGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVAS-SIDRNEMLEIQVFNYSKVFS 74
           R D +A +TFRG    ++V++N  +   ++E F W +    +D+   L + V ++  +  
Sbjct: 20  RSDPVASLTFRGVKKRTKVIKNSVNPV-WNEGFEWDLKGIPLDQGSELHVVVKDHETMGR 78

Query: 75  NKLIGTFRMVLQKVVEESHVEVTDT--LIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGD 132
           N+ +G  ++ L++V+    +  +    L+D        SL ++V Y    G V  +    
Sbjct: 79  NRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPT 138

Query: 133 FLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQ 192
            L             E    LP     +   GE+     G +   A            P 
Sbjct: 139 PL-------------EPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPF---LDQSGGPG 182

Query: 193 RPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPM 252
            P  P  L      H                         +  KRS P  +   S  +P 
Sbjct: 183 APTTPRKLPSRPPPHYP----------------------GIKRKRSAPTSRKLLS-DKPQ 219

Query: 253 DYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVM 312
           D+Q+ + VIE RQL G+N+ PVV V      K T + +  N P +NE   F+   SP  +
Sbjct: 220 DFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSPGEL 278

Query: 313 FDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGY 372
           FD+ I I+V+ S++L R+  L+G F+MDVGT+Y +P H +  KW +LSDPDD S+G +GY
Sbjct: 279 FDEPIFITVVDSRSL-RTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGY 337

Query: 373 VKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEGLPRM 432
           +K  + V+G GD      K    D++DIE NLL P GV    + A F +K++RAE LP+M
Sbjct: 338 LKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGV--ALRGAHFCLKVFRAEDLPQM 395

Query: 433 NTSLMANVKKAFIGEN--KDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPP 490
           + ++M NVK+ F  E+  K+LVDP+V+V FAG+   + + + +  P WN+ +    +FP 
Sbjct: 396 DDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPS 455

Query: 491 LCKRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDGDK-------GFLPTLGPAWVNMYG 541
           +C++M+++I D D++  ND+ + T ++ + KIS  G +       GFLPT GP ++N+YG
Sbjct: 456 MCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCYINLYG 514

Query: 542 STRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSN---PELTSSTEVQVEQAT 597
           S R +T   D + +LN G GEGV++R RLLL L  ++V+ S     +L +   ++VE+  
Sbjct: 515 SPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILRVEKYL 574

Query: 598 PISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDGLSRPQRPRPRK 657
                   +  ++ LF AF  A+M+  ++ D  I FEV+IGNYGN+ D    P       
Sbjct: 575 --------RRRKYSLFAAFYSATML--QDVDDAIQFEVSIGNYGNKFDMTCLP------- 617

Query: 658 EPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKPCIYIKSW 717
                                       S+T   R      +Y++LP+   KP + + S+
Sbjct: 618 --------------------------LASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSY 651

Query: 718 WPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYP--ERRLRGVLEELSCGCCRFL 775
           W D   R+   N +  IAD+LE GL  +   +K + S    +  +  + +EL  GC +  
Sbjct: 652 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 709

Query: 776 SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 835
            L D  +  S+ T LD+   +     L  + + A  L  ++    +   L   +++L +L
Sbjct: 710 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAA--LALKLGHSELPAALEQAEDWLLRL 766

Query: 836 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 894
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 767 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 826

Query: 895 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 827 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 854



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 1009
            F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 409  FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 445



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 453  DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
            DPY  V F  Q  KT V K++  P W++ ++F ++
Sbjct: 1161 DPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1195


>gi|195976769 dysferlin isoform 6 [Homo sapiens]
          Length = 2102

 Score =  723 bits (1867), Expect = 0.0
 Identities = 418/1084 (38%), Positives = 593/1084 (54%), Gaps = 162/1084 (14%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1141 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1200

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1201 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1253

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 1107
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1254 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1310

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1311 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1367

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1368 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1427

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGS---SSHSTGEVVVT----MEPEVPIKKL 1280
             F+  P    +PS                GG    S  S GE V+      EP +PI+  
Sbjct: 1428 SFLCDPYSAESPS--------------PQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLA 1473

Query: 1281 ETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMK 1340
            + +  L  T+ A                       P     +E  +DWWSK+FASI    
Sbjct: 1474 DGLSSLAPTNTA----------------------SPPSSPHEEEFIDWWSKFFASIG--- 1508

Query: 1341 EQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEK 1400
                ++E  G  LE+                                             
Sbjct: 1509 ----EREKCGSYLEKD-------------------------------------------- 1520

Query: 1401 KKPKIDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLC 1458
                 D LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   
Sbjct: 1521 ----FDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFK 1572

Query: 1459 VYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIA 1518
            +Y  PLPED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI 
Sbjct: 1573 IY--PLPEDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIK 1626

Query: 1519 IRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKI 1578
            I +GK  + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +
Sbjct: 1627 ISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVV 1686

Query: 1579 DLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKV 1638
            DLENR  SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV  
Sbjct: 1687 DLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMF 1745

Query: 1639 ANRVFTGPSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPD 1695
             ++ ++   EIE     N    P +E +AL  L+           LVPEHVE+RPL +P 
Sbjct: 1746 QDKEYS-IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPL 1796

Query: 1696 KPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGE 1755
            +P IEQG+L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGE
Sbjct: 1797 QPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGE 1855

Query: 1756 KSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMF 1815
            K SDI+V+GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +
Sbjct: 1856 KMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFW 1915

Query: 1816 SWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDV 1875
              D+TE KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++        
Sbjct: 1916 RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHP 1975

Query: 1876 P-LVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD-- 1932
               VS+F+QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+  
Sbjct: 1976 EWFVSLFEQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMN 2034

Query: 1933 -PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLV 1991
              LE P RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y  
Sbjct: 2035 PKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAA 2094

Query: 1992 KKIL 1995
             K++
Sbjct: 2095 MKLV 2098



 Score =  391 bits (1004), Expect = e-108
 Identities = 293/945 (31%), Positives = 464/945 (49%), Gaps = 131/945 (13%)

Query: 16  RGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVAS-SIDRNEMLEIQVFNYSKVFS 74
           R D +A +TFRG    ++V++N  +   ++E F W +    +D+   L + V ++  +  
Sbjct: 20  RSDPVASLTFRGVKKRTKVIKNSVNPV-WNEGFEWDLKGIPLDQGSELHVVVKDHETMGR 78

Query: 75  NKLIGTFRMVLQKVVEESHVEVTDT--LIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGD 132
           N+ +G  ++ L++V+    +  +    L+D        SL ++V Y    G V  +    
Sbjct: 79  NRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPT 138

Query: 133 FLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQ 192
            L             E    LP     +   GE+     G +   A            P 
Sbjct: 139 PL-------------EPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPF---LDQSGGPG 182

Query: 193 RPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPM 252
            P  P  L      H                         +  KRS P  +   S  +P 
Sbjct: 183 APTTPRKLPSRPPPHYP----------------------GIKRKRSAPTSRKLLS-DKPQ 219

Query: 253 DYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVM 312
           D+Q+ + VIE RQL G+N+ PVV V      K T + +  N P +NE   F+   SP  +
Sbjct: 220 DFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSPGEL 278

Query: 313 FDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGY 372
           FD+ I I+V+ S++L R+  L+G F+MDVGT+Y +P H +  KW +LSDPDD S+G +GY
Sbjct: 279 FDEPIFITVVDSRSL-RTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGY 337

Query: 373 VKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEGLPRM 432
           +K  + V+G GD      K    D++DIE NLL P GV    + A F +K++RAE LP+M
Sbjct: 338 LKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGV--ALRGAHFCLKVFRAEDLPQM 395

Query: 433 NTSLMANVKKAFIGEN--KDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPP 490
           + ++M NVK+ F  E+  K+LVDP+V+V FAG+   + + + +  P WN+ +    +FP 
Sbjct: 396 DDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPS 455

Query: 491 LCKRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDGDK---------------------G 527
           +C++M+++I D D++  ND+ + T ++ + KIS  G +                     G
Sbjct: 456 MCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEEEPAGAVKPSKASDLDDYLG 514

Query: 528 FLPTLGPAWVNMYGSTRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSN---P 583
           FLPT GP ++N+YGS R +T   D + +LN G GEGV++R RLLL L  ++V+ S     
Sbjct: 515 FLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVE 574

Query: 584 ELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNE 643
           +L +   ++VE+          +  ++ LF AF  A+M+  ++ D  I FEV+IGNYGN+
Sbjct: 575 DLPADDILRVEKYL--------RRRKYSLFAAFYSATML--QDVDDAIQFEVSIGNYGNK 624

Query: 644 VDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHL 703
            D    P                                   S+T   R      +Y++L
Sbjct: 625 FDMTCLP---------------------------------LASTTQYSRAVFDGCHYYYL 651

Query: 704 PYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYP--ERRLR 761
           P+   KP + + S+W D   R+   N +  IAD+LE GL  +   +K + S    +  + 
Sbjct: 652 PWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVA 711

Query: 762 GVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTV 821
            + +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L  ++    +
Sbjct: 712 QLTDELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAA--LALKLGHSEL 766

Query: 822 RDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETG 880
              L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       G
Sbjct: 767 PAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCG 826

Query: 881 KDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
           K+C K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 827 KNCGKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 868



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 1009
            F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 409  FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 445



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 453  DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
            DPY  V F  Q  KT V K++  P W++ ++F ++
Sbjct: 1175 DPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1209


>gi|195976764 dysferlin isoform 14 [Homo sapiens]
          Length = 2118

 Score =  723 bits (1867), Expect = 0.0
 Identities = 418/1084 (38%), Positives = 593/1084 (54%), Gaps = 162/1084 (14%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1157 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1216

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1217 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1269

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 1107
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1270 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1326

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1327 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1383

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1384 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1443

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGS---SSHSTGEVVVT----MEPEVPIKKL 1280
             F+  P    +PS                GG    S  S GE V+      EP +PI+  
Sbjct: 1444 SFLCDPYSAESPS--------------PQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLA 1489

Query: 1281 ETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMK 1340
            + +  L  T+ A                       P     +E  +DWWSK+FASI    
Sbjct: 1490 DGLSSLAPTNTA----------------------SPPSSPHEEEFIDWWSKFFASIG--- 1524

Query: 1341 EQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEK 1400
                ++E  G  LE+                                             
Sbjct: 1525 ----EREKCGSYLEKD-------------------------------------------- 1536

Query: 1401 KKPKIDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLC 1458
                 D LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   
Sbjct: 1537 ----FDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFK 1588

Query: 1459 VYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIA 1518
            +Y  PLPED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI 
Sbjct: 1589 IY--PLPEDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIK 1642

Query: 1519 IRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKI 1578
            I +GK  + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +
Sbjct: 1643 ISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVV 1702

Query: 1579 DLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKV 1638
            DLENR  SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV  
Sbjct: 1703 DLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMF 1761

Query: 1639 ANRVFTGPSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPD 1695
             ++ ++   EIE     N    P +E +AL  L+           LVPEHVE+RPL +P 
Sbjct: 1762 QDKEYS-IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPL 1812

Query: 1696 KPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGE 1755
            +P IEQG+L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGE
Sbjct: 1813 QPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGE 1871

Query: 1756 KSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMF 1815
            K SDI+V+GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +
Sbjct: 1872 KMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFW 1931

Query: 1816 SWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDV 1875
              D+TE KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++        
Sbjct: 1932 RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHP 1991

Query: 1876 P-LVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD-- 1932
               VS+F+QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+  
Sbjct: 1992 EWFVSLFEQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMN 2050

Query: 1933 -PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLV 1991
              LE P RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y  
Sbjct: 2051 PKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAA 2110

Query: 1992 KKIL 1995
             K++
Sbjct: 2111 MKLV 2114



 Score =  392 bits (1007), Expect = e-108
 Identities = 295/942 (31%), Positives = 469/942 (49%), Gaps = 112/942 (11%)

Query: 18  DRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVAS-SIDRNEMLEIQVFNYSKVFSNK 76
           D      F G    ++V++N  +   ++E F W +    +D+   L + V ++  +  N+
Sbjct: 21  DAYCSAVFAGVKKRTKVIKNSVNPV-WNEGFEWDLKGIPLDQGSELHVVVKDHETMGRNR 79

Query: 77  LIGTFRMVLQKVVEESHVEVTDT--LIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFL 134
            +G  ++ L++V+    +  +    L+D        SL ++V Y    G V  +     L
Sbjct: 80  FLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPTPL 139

Query: 135 GDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRP 194
                 E      + D +  G +           R    S+ S   +    S K+ P   
Sbjct: 140 ------EPSPTLPDLDVVAGGGQS----------RAETWSLLSDSTMDTRYSGKKWPAPT 183

Query: 195 DEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTT-------------NVSNKRSKPD 241
           D     + ED        GD  +P         A TT              +  KRS P 
Sbjct: 184 DTGGEEDTEDQG----LTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT 239

Query: 242 IKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYF 301
            +   S  +P D+Q+ + VIE RQL G+N+ PVV V      K T + +  N P +NE  
Sbjct: 240 SRKLLS-DKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETL 297

Query: 302 VFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSD 361
            F+   SP  +FD+ I I+V+ S++L R+  L+G F+MDVGT+Y +P H +  KW +LSD
Sbjct: 298 FFNLFDSPGELFDEPIFITVVDSRSL-RTDALLGEFRMDVGTIYREPRHAYLRKWLLLSD 356

Query: 362 PDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYV 421
           PDD S+G +GY+K  + V+G GD      K    D++DIE NLL P GV    + A F +
Sbjct: 357 PDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGV--ALRGAHFCL 414

Query: 422 KIYRAEGLPRMNTSLMANVKKAFIGEN--KDLVDPYVQVFFAGQKGKTSVQKSSYEPLWN 479
           K++RAE LP+M+ ++M NVK+ F  E+  K+LVDP+V+V FAG+   + + + +  P WN
Sbjct: 415 KVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWN 474

Query: 480 EQVVFTDLFPPLCKRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDGDK-------GFLP 530
           + +    +FP +C++M+++I D D++  ND+ + T ++ + KIS  G +       GFLP
Sbjct: 475 QNITLPAMFPSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGFLP 533

Query: 531 TLGPAWVNMYGSTRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSN---PELT 586
           T GP ++N+YGS R +T   D + +LN G GEGV++R RLLL L  ++V+ S     +L 
Sbjct: 534 TFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLP 593

Query: 587 SSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDG 646
           +   ++VE+          +  ++ LF AF  A+M+  ++ D  I FEV+IGNYGN+ D 
Sbjct: 594 ADDILRVEKYL--------RRRKYSLFAAFYSATML--QDVDDAIQFEVSIGNYGNKFDM 643

Query: 647 LSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYL 706
              P                                   S+T   R      +Y++LP+ 
Sbjct: 644 TCLP---------------------------------LASTTQYSRAVFDGCHYYYLPWG 670

Query: 707 ERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYP--ERRLRGVL 764
             KP + + S+W D   R+   N +  IAD+LE GL  +   +K + S    +  +  + 
Sbjct: 671 NVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLT 730

Query: 765 EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 824
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L  ++    +   
Sbjct: 731 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAA--LALKLGHSELPAA 785

Query: 825 LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 883
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 786 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 845

Query: 884 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 846 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 884



 Score = 35.4 bits (80), Expect = 0.56
 Identities = 15/31 (48%), Positives = 19/31 (61%)

Query: 450 DLVDPYVQVFFAGQKGKTSVQKSSYEPLWNE 480
           D+ D Y    FAG K +T V K+S  P+WNE
Sbjct: 18  DISDAYCSAVFAGVKKRTKVIKNSVNPVWNE 48



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 1009
            F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 439  FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 475



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 453  DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
            DPY  V F  Q  KT V K++  P W++ ++F ++
Sbjct: 1191 DPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1225


>gi|195976758 dysferlin isoform 11 [Homo sapiens]
          Length = 2101

 Score =  723 bits (1867), Expect = 0.0
 Identities = 418/1084 (38%), Positives = 593/1084 (54%), Gaps = 162/1084 (14%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1140 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1199

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1200 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1252

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 1107
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1253 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1309

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1310 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1366

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1367 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1426

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGS---SSHSTGEVVVT----MEPEVPIKKL 1280
             F+  P    +PS                GG    S  S GE V+      EP +PI+  
Sbjct: 1427 SFLCDPYSAESPS--------------PQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLA 1472

Query: 1281 ETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMK 1340
            + +  L  T+ A                       P     +E  +DWWSK+FASI    
Sbjct: 1473 DGLSSLAPTNTA----------------------SPPSSPHEEEFIDWWSKFFASIG--- 1507

Query: 1341 EQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEK 1400
                ++E  G  LE+                                             
Sbjct: 1508 ----EREKCGSYLEKD-------------------------------------------- 1519

Query: 1401 KKPKIDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLC 1458
                 D LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   
Sbjct: 1520 ----FDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFK 1571

Query: 1459 VYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIA 1518
            +Y  PLPED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI 
Sbjct: 1572 IY--PLPEDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIK 1625

Query: 1519 IRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKI 1578
            I +GK  + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +
Sbjct: 1626 ISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVV 1685

Query: 1579 DLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKV 1638
            DLENR  SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV  
Sbjct: 1686 DLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMF 1744

Query: 1639 ANRVFTGPSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPD 1695
             ++ ++   EIE     N    P +E +AL  L+           LVPEHVE+RPL +P 
Sbjct: 1745 QDKEYS-IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPL 1795

Query: 1696 KPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGE 1755
            +P IEQG+L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGE
Sbjct: 1796 QPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGE 1854

Query: 1756 KSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMF 1815
            K SDI+V+GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +
Sbjct: 1855 KMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFW 1914

Query: 1816 SWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDV 1875
              D+TE KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++        
Sbjct: 1915 RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHP 1974

Query: 1876 P-LVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD-- 1932
               VS+F+QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+  
Sbjct: 1975 EWFVSLFEQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMN 2033

Query: 1933 -PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLV 1991
              LE P RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y  
Sbjct: 2034 PKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAA 2093

Query: 1992 KKIL 1995
             K++
Sbjct: 2094 MKLV 2097



 Score =  382 bits (980), Expect = e-105
 Identities = 289/943 (30%), Positives = 458/943 (48%), Gaps = 131/943 (13%)

Query: 18  DRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVAS-SIDRNEMLEIQVFNYSKVFSNK 76
           D      F G    ++V++N  +   ++E F W +    +D+   L + V ++  +  N+
Sbjct: 21  DAYCSAVFAGVKKRTKVIKNSVNPV-WNEGFEWDLKGIPLDQGSELHVVVKDHETMGRNR 79

Query: 77  LIGTFRMVLQKVVEESHVEVTDT--LIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFL 134
            +G  ++ L++V+    +  +    L+D        SL ++V Y    G V  +     L
Sbjct: 80  FLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPTPL 139

Query: 135 GDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRP 194
                        E    LP     +   GE+     G +   A            P  P
Sbjct: 140 -------------EPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPF---LDQSGGPGAP 183

Query: 195 DEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDY 254
             P  L      H                         +  KRS P  +   S  +P D+
Sbjct: 184 TTPRKLPSRPPPHYP----------------------GIKRKRSAPTSRKLLS-DKPQDF 220

Query: 255 QVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFD 314
           Q+ + VIE RQL G+N+ PVV V      K T + +  N P +NE   F+   SP  +FD
Sbjct: 221 QIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSPGELFD 279

Query: 315 KIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGYVK 374
           + I I+V+ S++L R+  L+G F+MDVGT+Y +P H +  KW +LSDPDD S+G +GY+K
Sbjct: 280 EPIFITVVDSRSL-RTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLK 338

Query: 375 CDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEGLPRMNT 434
             + V+G GD      K    D++DIE NLL P GV    + A F +K++RAE LP+M+ 
Sbjct: 339 TSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGV--ALRGAHFCLKVFRAEDLPQMDD 396

Query: 435 SLMANVKKAFIGEN--KDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLC 492
           ++M NVK+ F  E+  K+LVDP+V+V FAG+   + + + +  P WN+ +    +FP +C
Sbjct: 397 AVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMC 456

Query: 493 KRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDGDK---------------------GFL 529
           ++M+++I D D++  ND+ + T ++ + KIS  G +                     GFL
Sbjct: 457 EKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEEEPAGAVKPSKASDLDDYLGFL 515

Query: 530 PTLGPAWVNMYGSTRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSN---PEL 585
           PT GP ++N+YGS R +T   D + +LN G GEGV++R RLLL L  ++V+ S     +L
Sbjct: 516 PTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDL 575

Query: 586 TSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVD 645
            +   ++VE+          +  ++ LF AF  A+M+  ++ D  I FEV+IGNYGN+ D
Sbjct: 576 PADDILRVEKYL--------RRRKYSLFAAFYSATML--QDVDDAIQFEVSIGNYGNKFD 625

Query: 646 GLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPY 705
               P                                   S+T   R      +Y++LP+
Sbjct: 626 MTCLP---------------------------------LASTTQYSRAVFDGCHYYYLPW 652

Query: 706 LERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYP--ERRLRGV 763
              KP + + S+W D   R+   N +  IAD+LE GL  +   +K + S    +  +  +
Sbjct: 653 GNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQL 712

Query: 764 LEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRD 823
            +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L  ++    +  
Sbjct: 713 TDELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAA--LALKLGHSELPA 767

Query: 824 KLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKD 882
            L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+
Sbjct: 768 ALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKN 827

Query: 883 CAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
           C K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 828 CGKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 867



 Score = 35.4 bits (80), Expect = 0.56
 Identities = 15/31 (48%), Positives = 19/31 (61%)

Query: 450 DLVDPYVQVFFAGQKGKTSVQKSSYEPLWNE 480
           D+ D Y    FAG K +T V K+S  P+WNE
Sbjct: 18  DISDAYCSAVFAGVKKRTKVIKNSVNPVWNE 48



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 1009
            F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 408  FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 444



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 453  DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
            DPY  V F  Q  KT V K++  P W++ ++F ++
Sbjct: 1174 DPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1208


>gi|195976756 dysferlin isoform 10 [Homo sapiens]
          Length = 2087

 Score =  723 bits (1867), Expect = 0.0
 Identities = 418/1084 (38%), Positives = 593/1084 (54%), Gaps = 162/1084 (14%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1126 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1185

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1186 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1238

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 1107
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1239 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1295

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1296 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1352

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1353 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1412

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGS---SSHSTGEVVVT----MEPEVPIKKL 1280
             F+  P    +PS                GG    S  S GE V+      EP +PI+  
Sbjct: 1413 SFLCDPYSAESPS--------------PQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLA 1458

Query: 1281 ETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMK 1340
            + +  L  T+ A                       P     +E  +DWWSK+FASI    
Sbjct: 1459 DGLSSLAPTNTA----------------------SPPSSPHEEEFIDWWSKFFASIG--- 1493

Query: 1341 EQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEK 1400
                ++E  G  LE+                                             
Sbjct: 1494 ----EREKCGSYLEKD-------------------------------------------- 1505

Query: 1401 KKPKIDELKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLC 1458
                 D LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   
Sbjct: 1506 ----FDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFK 1557

Query: 1459 VYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIA 1518
            +Y  PLPED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI 
Sbjct: 1558 IY--PLPEDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIK 1611

Query: 1519 IRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKI 1578
            I +GK  + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +
Sbjct: 1612 ISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVV 1671

Query: 1579 DLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKV 1638
            DLENR  SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV  
Sbjct: 1672 DLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMF 1730

Query: 1639 ANRVFTGPSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPD 1695
             ++ ++   EIE     N    P +E +AL  L+           LVPEHVE+RPL +P 
Sbjct: 1731 QDKEYS-IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPL 1781

Query: 1696 KPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGE 1755
            +P IEQG+L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGE
Sbjct: 1782 QPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGE 1840

Query: 1756 KSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMF 1815
            K SDI+V+GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +
Sbjct: 1841 KMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFW 1900

Query: 1816 SWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDV 1875
              D+TE KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++        
Sbjct: 1901 RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHP 1960

Query: 1876 P-LVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD-- 1932
               VS+F+QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+  
Sbjct: 1961 EWFVSLFEQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMN 2019

Query: 1933 -PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLV 1991
              LE P RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y  
Sbjct: 2020 PKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAA 2079

Query: 1992 KKIL 1995
             K++
Sbjct: 2080 MKLV 2083



 Score =  387 bits (994), Expect = e-107
 Identities = 289/929 (31%), Positives = 458/929 (49%), Gaps = 117/929 (12%)

Query: 18  DRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVAS-SIDRNEMLEIQVFNYSKVFSNK 76
           D      F G    ++V++N  +   ++E F W +    +D+   L + V ++  +  N+
Sbjct: 21  DAYCSAVFAGVKKRTKVIKNSVNPV-WNEGFEWDLKGIPLDQGSELHVVVKDHETMGRNR 79

Query: 77  LIGTFRMVLQKVVEESHVEVTDT--LIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFL 134
            +G  ++ L++V+    +  +    L+D        SL ++V Y    G V  +     L
Sbjct: 80  FLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPTPL 139

Query: 135 GDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRP 194
                        E    LP     +   GE+     G +   A            P  P
Sbjct: 140 -------------EPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPF---LDQSGGPGAP 183

Query: 195 DEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDY 254
             P  L      H                         +  KRS P  +   S  +P D+
Sbjct: 184 TTPRKLPSRPPPHYP----------------------GIKRKRSAPTSRKLLS-DKPQDF 220

Query: 255 QVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFD 314
           Q+ + VIE RQL G+N+ PVV V      K T + +  N P +NE   F+   SP  +FD
Sbjct: 221 QIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSPGELFD 279

Query: 315 KIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGYVK 374
           + I I+V+ S++L R+  L+G F+MDVGT+Y +P H +  KW +LSDPDD S+G +GY+K
Sbjct: 280 EPIFITVVDSRSL-RTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLK 338

Query: 375 CDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEGLPRMNT 434
             + V+G GD      K    D++DIE NLL P GV    + A F +K++RAE LP+M+ 
Sbjct: 339 TSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGV--ALRGAHFCLKVFRAEDLPQMDD 396

Query: 435 SLMANVKKAFIGEN--KDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLC 492
           ++M NVK+ F  E+  K+LVDP+V+V FAG+   + + + +  P WN+ +    +FP +C
Sbjct: 397 AVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMC 456

Query: 493 KRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDGDK-------GFLPTLGPAWVNMYGST 543
           ++M+++I D D++  ND+ + T ++ + KIS  G +       GFLPT GP ++N+YGS 
Sbjct: 457 EKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCYINLYGSP 515

Query: 544 RNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSN---PELTSSTEVQVEQATPI 599
           R +T   D + +LN G GEGV++R RLLL L  ++V+ S     +L +   ++VE+    
Sbjct: 516 REFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILRVEKYL-- 573

Query: 600 SESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDGLSRPQRPRPRKEP 659
                 +  ++ LF AF  A+M+  ++ D  I FEV+IGNYGN+ D    P         
Sbjct: 574 ------RRRKYSLFAAFYSATML--QDVDDAIQFEVSIGNYGNKFDMTCLP--------- 616

Query: 660 GDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKPCIYIKSWWP 719
                                     S+T   R      +Y++LP+   KP + + S+W 
Sbjct: 617 ------------------------LASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWE 652

Query: 720 DQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYP--ERRLRGVLEELSCGCCRFLSL 777
           D   R+   N +  IAD+LE GL  +   +K + S    +  +  + +EL  GC +   L
Sbjct: 653 DISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ--PL 710

Query: 778 ADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRF 837
            D  +  S+ T LD+   +     L  + + A  L  ++    +   L   +++L +LR 
Sbjct: 711 GDIHETPSA-THLDQYLYQLRTHHLSQITEAA--LALKLGHSELPAALEQAEDWLLRLRA 767

Query: 838 LADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLPGK 896
           LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P +
Sbjct: 768 LAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPME 827

Query: 897 RGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
           +  G A   VQ +V+  LW GLS   KEF
Sbjct: 828 KVPG-ARMPVQIRVK--LWFGLSVDEKEF 853



 Score = 35.4 bits (80), Expect = 0.56
 Identities = 15/31 (48%), Positives = 19/31 (61%)

Query: 450 DLVDPYVQVFFAGQKGKTSVQKSSYEPLWNE 480
           D+ D Y    FAG K +T V K+S  P+WNE
Sbjct: 18  DISDAYCSAVFAGVKKRTKVIKNSVNPVWNE 48



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 1009
            F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 408  FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 444



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 453  DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
            DPY  V F  Q  KT V K++  P W++ ++F ++
Sbjct: 1160 DPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1194


>gi|195976821 dysferlin isoform 2 [Homo sapiens]
          Length = 2081

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1141 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1200

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1201 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1253

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 1107
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1254 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1310

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1311 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1367

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1368 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1427

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 1287
             F+  P    +PS                GG    S                      L 
Sbjct: 1428 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1452

Query: 1288 ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 1347
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1453 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1490

Query: 1348 PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 1407
              G  LE+                                                  D 
Sbjct: 1491 KCGSYLEKD------------------------------------------------FDT 1502

Query: 1408 LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 1465
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1503 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1556

Query: 1466 EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 1525
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1557 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1612

Query: 1526 IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 1585
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1613 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1672

Query: 1586 SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 1645
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1673 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1730

Query: 1646 PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1702
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1731 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1782

Query: 1703 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1762
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1783 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1841

Query: 1763 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1822
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1842 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1901

Query: 1823 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1881
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1902 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1961

Query: 1882 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1938
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1962 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2020

Query: 1939 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1995
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2021 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2077



 Score =  391 bits (1004), Expect = e-108
 Identities = 293/945 (31%), Positives = 464/945 (49%), Gaps = 131/945 (13%)

Query: 16  RGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVAS-SIDRNEMLEIQVFNYSKVFS 74
           R D +A +TFRG    ++V++N  +   ++E F W +    +D+   L + V ++  +  
Sbjct: 20  RSDPVASLTFRGVKKRTKVIKNSVNPV-WNEGFEWDLKGIPLDQGSELHVVVKDHETMGR 78

Query: 75  NKLIGTFRMVLQKVVEESHVEVTDT--LIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGD 132
           N+ +G  ++ L++V+    +  +    L+D        SL ++V Y    G V  +    
Sbjct: 79  NRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPT 138

Query: 133 FLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQ 192
            L             E    LP     +   GE+     G +   A            P 
Sbjct: 139 PL-------------EPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPF---LDQSGGPG 182

Query: 193 RPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPM 252
            P  P  L      H                         +  KRS P  +   S  +P 
Sbjct: 183 APTTPRKLPSRPPPHYP----------------------GIKRKRSAPTSRKLLS-DKPQ 219

Query: 253 DYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVM 312
           D+Q+ + VIE RQL G+N+ PVV V      K T + +  N P +NE   F+   SP  +
Sbjct: 220 DFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSPGEL 278

Query: 313 FDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGY 372
           FD+ I I+V+ S++L R+  L+G F+MDVGT+Y +P H +  KW +LSDPDD S+G +GY
Sbjct: 279 FDEPIFITVVDSRSL-RTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGY 337

Query: 373 VKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEGLPRM 432
           +K  + V+G GD      K    D++DIE NLL P GV    + A F +K++RAE LP+M
Sbjct: 338 LKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGV--ALRGAHFCLKVFRAEDLPQM 395

Query: 433 NTSLMANVKKAFIGEN--KDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPP 490
           + ++M NVK+ F  E+  K+LVDP+V+V FAG+   + + + +  P WN+ +    +FP 
Sbjct: 396 DDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPS 455

Query: 491 LCKRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDGDK---------------------G 527
           +C++M+++I D D++  ND+ + T ++ + KIS  G +                     G
Sbjct: 456 MCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEEEPAGAVKPSKASDLDDYLG 514

Query: 528 FLPTLGPAWVNMYGSTRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSN---P 583
           FLPT GP ++N+YGS R +T   D + +LN G GEGV++R RLLL L  ++V+ S     
Sbjct: 515 FLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVE 574

Query: 584 ELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNE 643
           +L +   ++VE+          +  ++ LF AF  A+M+  ++ D  I FEV+IGNYGN+
Sbjct: 575 DLPADDILRVEKYL--------RRRKYSLFAAFYSATML--QDVDDAIQFEVSIGNYGNK 624

Query: 644 VDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHL 703
            D    P                                   S+T   R      +Y++L
Sbjct: 625 FDMTCLP---------------------------------LASTTQYSRAVFDGCHYYYL 651

Query: 704 PYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYP--ERRLR 761
           P+   KP + + S+W D   R+   N +  IAD+LE GL  +   +K + S    +  + 
Sbjct: 652 PWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVA 711

Query: 762 GVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTV 821
            + +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L  ++    +
Sbjct: 712 QLTDELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAA--LALKLGHSEL 766

Query: 822 RDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETG 880
              L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       G
Sbjct: 767 PAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCG 826

Query: 881 KDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
           K+C K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 827 KNCGKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 868



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 1009
            F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 409  FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 445



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 453  DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
            DPY  V F  Q  KT V K++  P W++ ++F ++
Sbjct: 1175 DPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1209


>gi|4503431 dysferlin isoform 8 [Homo sapiens]
          Length = 2080

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1140 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1199

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1200 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1252

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 1107
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1253 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1309

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1310 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1366

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1367 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1426

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 1287
             F+  P    +PS                GG    S                      L 
Sbjct: 1427 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1451

Query: 1288 ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 1347
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1452 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1489

Query: 1348 PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 1407
              G  LE+                                                  D 
Sbjct: 1490 KCGSYLEKD------------------------------------------------FDT 1501

Query: 1408 LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 1465
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1502 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1555

Query: 1466 EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 1525
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1556 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1611

Query: 1526 IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 1585
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1612 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1671

Query: 1586 SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 1645
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1672 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1729

Query: 1646 PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1702
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1730 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1781

Query: 1703 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1762
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1782 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1840

Query: 1763 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1822
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1841 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1900

Query: 1823 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1881
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1901 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1960

Query: 1882 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1938
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1961 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2019

Query: 1939 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1995
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2020 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2076



 Score =  382 bits (980), Expect = e-105
 Identities = 289/943 (30%), Positives = 458/943 (48%), Gaps = 131/943 (13%)

Query: 18  DRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVAS-SIDRNEMLEIQVFNYSKVFSNK 76
           D      F G    ++V++N  +   ++E F W +    +D+   L + V ++  +  N+
Sbjct: 21  DAYCSAVFAGVKKRTKVIKNSVNPV-WNEGFEWDLKGIPLDQGSELHVVVKDHETMGRNR 79

Query: 77  LIGTFRMVLQKVVEESHVEVTDT--LIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFL 134
            +G  ++ L++V+    +  +    L+D        SL ++V Y    G V  +     L
Sbjct: 80  FLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPTPL 139

Query: 135 GDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRP 194
                        E    LP     +   GE+     G +   A            P  P
Sbjct: 140 -------------EPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPF---LDQSGGPGAP 183

Query: 195 DEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDY 254
             P  L      H                         +  KRS P  +   S  +P D+
Sbjct: 184 TTPRKLPSRPPPHYP----------------------GIKRKRSAPTSRKLLS-DKPQDF 220

Query: 255 QVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFD 314
           Q+ + VIE RQL G+N+ PVV V      K T + +  N P +NE   F+   SP  +FD
Sbjct: 221 QIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSPGELFD 279

Query: 315 KIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGYVK 374
           + I I+V+ S++L R+  L+G F+MDVGT+Y +P H +  KW +LSDPDD S+G +GY+K
Sbjct: 280 EPIFITVVDSRSL-RTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLK 338

Query: 375 CDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEGLPRMNT 434
             + V+G GD      K    D++DIE NLL P GV    + A F +K++RAE LP+M+ 
Sbjct: 339 TSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGV--ALRGAHFCLKVFRAEDLPQMDD 396

Query: 435 SLMANVKKAFIGEN--KDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLC 492
           ++M NVK+ F  E+  K+LVDP+V+V FAG+   + + + +  P WN+ +    +FP +C
Sbjct: 397 AVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMC 456

Query: 493 KRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDGDK---------------------GFL 529
           ++M+++I D D++  ND+ + T ++ + KIS  G +                     GFL
Sbjct: 457 EKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEEEPAGAVKPSKASDLDDYLGFL 515

Query: 530 PTLGPAWVNMYGSTRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSN---PEL 585
           PT GP ++N+YGS R +T   D + +LN G GEGV++R RLLL L  ++V+ S     +L
Sbjct: 516 PTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDL 575

Query: 586 TSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVD 645
            +   ++VE+          +  ++ LF AF  A+M+  ++ D  I FEV+IGNYGN+ D
Sbjct: 576 PADDILRVEKYL--------RRRKYSLFAAFYSATML--QDVDDAIQFEVSIGNYGNKFD 625

Query: 646 GLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPY 705
               P                                   S+T   R      +Y++LP+
Sbjct: 626 MTCLP---------------------------------LASTTQYSRAVFDGCHYYYLPW 652

Query: 706 LERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYP--ERRLRGV 763
              KP + + S+W D   R+   N +  IAD+LE GL  +   +K + S    +  +  +
Sbjct: 653 GNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQL 712

Query: 764 LEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRD 823
            +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L  ++    +  
Sbjct: 713 TDELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAA--LALKLGHSELPA 767

Query: 824 KLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKD 882
            L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+
Sbjct: 768 ALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKN 827

Query: 883 CAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
           C K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 828 CGKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 867



 Score = 35.4 bits (80), Expect = 0.56
 Identities = 15/31 (48%), Positives = 19/31 (61%)

Query: 450 DLVDPYVQVFFAGQKGKTSVQKSSYEPLWNE 480
           D+ D Y    FAG K +T V K+S  P+WNE
Sbjct: 18  DISDAYCSAVFAGVKKRTKVIKNSVNPVWNE 48



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 1009
            F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 408  FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 444



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 453  DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
            DPY  V F  Q  KT V K++  P W++ ++F ++
Sbjct: 1174 DPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1208


>gi|195976777 dysferlin isoform 3 [Homo sapiens]
          Length = 2067

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1127 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1186

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1187 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1239

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 1107
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1240 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1296

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1297 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1353

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1354 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1413

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 1287
             F+  P    +PS                GG    S                      L 
Sbjct: 1414 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1438

Query: 1288 ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 1347
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1439 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1476

Query: 1348 PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 1407
              G  LE+                                                  D 
Sbjct: 1477 KCGSYLEKD------------------------------------------------FDT 1488

Query: 1408 LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 1465
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1489 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1542

Query: 1466 EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 1525
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1543 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1598

Query: 1526 IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 1585
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1599 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1658

Query: 1586 SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 1645
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1659 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1716

Query: 1646 PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1702
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1717 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1768

Query: 1703 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1762
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1769 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1827

Query: 1763 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1822
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1828 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1887

Query: 1823 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1881
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1888 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1947

Query: 1882 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1938
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1948 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2006

Query: 1939 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1995
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2007 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2063



 Score =  396 bits (1018), Expect = e-109
 Identities = 293/931 (31%), Positives = 464/931 (49%), Gaps = 117/931 (12%)

Query: 16  RGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVAS-SIDRNEMLEIQVFNYSKVFS 74
           R D +A +TFRG    ++V++N  +   ++E F W +    +D+   L + V ++  +  
Sbjct: 20  RSDPVASLTFRGVKKRTKVIKNSVNPV-WNEGFEWDLKGIPLDQGSELHVVVKDHETMGR 78

Query: 75  NKLIGTFRMVLQKVVEESHVEVTDT--LIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGD 132
           N+ +G  ++ L++V+    +  +    L+D        SL ++V Y    G V  +    
Sbjct: 79  NRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPT 138

Query: 133 FLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQ 192
            L             E    LP     +   GE+     G +   A            P 
Sbjct: 139 PL-------------EPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPF---LDQSGGPG 182

Query: 193 RPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPM 252
            P  P  L      H                         +  KRS P  +   S  +P 
Sbjct: 183 APTTPRKLPSRPPPHYP----------------------GIKRKRSAPTSRKLLS-DKPQ 219

Query: 253 DYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVM 312
           D+Q+ + VIE RQL G+N+ PVV V      K T + +  N P +NE   F+   SP  +
Sbjct: 220 DFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSPGEL 278

Query: 313 FDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGY 372
           FD+ I I+V+ S++L R+  L+G F+MDVGT+Y +P H +  KW +LSDPDD S+G +GY
Sbjct: 279 FDEPIFITVVDSRSL-RTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGY 337

Query: 373 VKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEGLPRM 432
           +K  + V+G GD      K    D++DIE NLL P GV    + A F +K++RAE LP+M
Sbjct: 338 LKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGV--ALRGAHFCLKVFRAEDLPQM 395

Query: 433 NTSLMANVKKAFIGEN--KDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPP 490
           + ++M NVK+ F  E+  K+LVDP+V+V FAG+   + + + +  P WN+ +    +FP 
Sbjct: 396 DDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPS 455

Query: 491 LCKRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDGDK-------GFLPTLGPAWVNMYG 541
           +C++M+++I D D++  ND+ + T ++ + KIS  G +       GFLPT GP ++N+YG
Sbjct: 456 MCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCYINLYG 514

Query: 542 STRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSN---PELTSSTEVQVEQAT 597
           S R +T   D + +LN G GEGV++R RLLL L  ++V+ S     +L +   ++VE+  
Sbjct: 515 SPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILRVEKYL 574

Query: 598 PISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDGLSRPQRPRPRK 657
                   +  ++ LF AF  A+M+  ++ D  I FEV+IGNYGN+ D    P       
Sbjct: 575 --------RRRKYSLFAAFYSATML--QDVDDAIQFEVSIGNYGNKFDMTCLP------- 617

Query: 658 EPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKPCIYIKSW 717
                                       S+T   R      +Y++LP+   KP + + S+
Sbjct: 618 --------------------------LASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSY 651

Query: 718 WPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYP--ERRLRGVLEELSCGCCRFL 775
           W D   R+   N +  IAD+LE GL  +   +K + S    +  +  + +EL  GC +  
Sbjct: 652 WEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ-- 709

Query: 776 SLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKL 835
            L D  +  S+ T LD+   +     L  + + A  L  ++    +   L   +++L +L
Sbjct: 710 PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAA--LALKLGHSELPAALEQAEDWLLRL 766

Query: 836 RFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLP 894
           R LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P
Sbjct: 767 RALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYP 826

Query: 895 GKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
            ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 827 MEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 854



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 1009
            F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 409  FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 445



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 453  DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
            DPY  V F  Q  KT V K++  P W++ ++F ++
Sbjct: 1161 DPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1195


>gi|195976775 dysferlin isoform 4 [Homo sapiens]
          Length = 2098

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1158 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1217

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1218 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1270

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 1107
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1271 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1327

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1328 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1384

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1385 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1444

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 1287
             F+  P    +PS                GG    S                      L 
Sbjct: 1445 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1469

Query: 1288 ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 1347
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1470 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1507

Query: 1348 PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 1407
              G  LE+                                                  D 
Sbjct: 1508 KCGSYLEKD------------------------------------------------FDT 1519

Query: 1408 LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 1465
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1520 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1573

Query: 1466 EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 1525
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1574 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1629

Query: 1526 IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 1585
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1630 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1689

Query: 1586 SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 1645
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1690 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1747

Query: 1646 PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1702
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1748 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1799

Query: 1703 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1762
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1800 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1858

Query: 1763 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1822
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1859 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1918

Query: 1823 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1881
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1919 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1978

Query: 1882 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1938
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1979 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2037

Query: 1939 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1995
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2038 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2094



 Score =  401 bits (1031), Expect = e-111
 Identities = 299/944 (31%), Positives = 475/944 (50%), Gaps = 112/944 (11%)

Query: 16  RGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVAS-SIDRNEMLEIQVFNYSKVFS 74
           R D +A +TFRG    ++V++N  +   ++E F W +    +D+   L + V ++  +  
Sbjct: 20  RSDPVASLTFRGVKKRTKVIKNSVNPV-WNEGFEWDLKGIPLDQGSELHVVVKDHETMGR 78

Query: 75  NKLIGTFRMVLQKVVEESHVEVTDT--LIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGD 132
           N+ +G  ++ L++V+    +  +    L+D        SL ++V Y    G V  +    
Sbjct: 79  NRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPT 138

Query: 133 FLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQ 192
            L      E      + D +  G +           R    S+ S   +    S K+ P 
Sbjct: 139 PL------EPSPTLPDLDVVAGGGQS----------RAETWSLLSDSTMDTRYSGKKWPA 182

Query: 193 RPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTT-------------NVSNKRSK 239
             D     + ED        GD  +P         A TT              +  KRS 
Sbjct: 183 PTDTGGEEDTEDQG----LTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSA 238

Query: 240 PDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNE 299
           P  +   S  +P D+Q+ + VIE RQL G+N+ PVV V      K T + +  N P +NE
Sbjct: 239 PTSRKLLS-DKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNE 296

Query: 300 YFVFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAIL 359
              F+   SP  +FD+ I I+V+ S++L R+  L+G F+MDVGT+Y +P H +  KW +L
Sbjct: 297 TLFFNLFDSPGELFDEPIFITVVDSRSL-RTDALLGEFRMDVGTIYREPRHAYLRKWLLL 355

Query: 360 SDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARF 419
           SDPDD S+G +GY+K  + V+G GD      K    D++DIE NLL P GV    + A F
Sbjct: 356 SDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGV--ALRGAHF 413

Query: 420 YVKIYRAEGLPRMNTSLMANVKKAFIGEN--KDLVDPYVQVFFAGQKGKTSVQKSSYEPL 477
            +K++RAE LP+M+ ++M NVK+ F  E+  K+LVDP+V+V FAG+   + + + +  P 
Sbjct: 414 CLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQ 473

Query: 478 WNEQVVFTDLFPPLCKRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDGDK-------GF 528
           WN+ +    +FP +C++M+++I D D++  ND+ + T ++ + KIS  G +       GF
Sbjct: 474 WNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGF 532

Query: 529 LPTLGPAWVNMYGSTRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSN---PE 584
           LPT GP ++N+YGS R +T   D + +LN G GEGV++R RLLL L  ++V+ S     +
Sbjct: 533 LPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVED 592

Query: 585 LTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEV 644
           L +   ++VE+          +  ++ LF AF  A+M+  ++ D  I FEV+IGNYGN+ 
Sbjct: 593 LPADDILRVEKYL--------RRRKYSLFAAFYSATML--QDVDDAIQFEVSIGNYGNKF 642

Query: 645 DGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLP 704
           D    P                                   S+T   R      +Y++LP
Sbjct: 643 DMTCLP---------------------------------LASTTQYSRAVFDGCHYYYLP 669

Query: 705 YLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYP--ERRLRG 762
           +   KP + + S+W D   R+   N +  IAD+LE GL  +   +K + S    +  +  
Sbjct: 670 WGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQ 729

Query: 763 VLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVR 822
           + +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L  ++    + 
Sbjct: 730 LTDELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAA--LALKLGHSELP 784

Query: 823 DKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGK 881
             L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK
Sbjct: 785 AALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGK 844

Query: 882 DCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
           +C K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 845 NCGKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 885



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 1009
            F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 440  FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 476



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 453  DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
            DPY  V F  Q  KT V K++  P W++ ++F ++
Sbjct: 1192 DPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1226


>gi|195976766 dysferlin isoform 7 [Homo sapiens]
          Length = 2112

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1172 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1231

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1232 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1284

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 1107
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1285 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1341

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1342 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1398

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1399 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1458

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 1287
             F+  P    +PS                GG    S                      L 
Sbjct: 1459 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1483

Query: 1288 ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 1347
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1484 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1521

Query: 1348 PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 1407
              G  LE+                                                  D 
Sbjct: 1522 KCGSYLEKD------------------------------------------------FDT 1533

Query: 1408 LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 1465
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1534 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1587

Query: 1466 EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 1525
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1588 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1643

Query: 1526 IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 1585
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1644 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1703

Query: 1586 SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 1645
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1704 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1761

Query: 1646 PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1702
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1762 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1813

Query: 1703 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1762
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1814 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1872

Query: 1763 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1822
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1873 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1932

Query: 1823 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1881
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1933 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1992

Query: 1882 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1938
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1993 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2051

Query: 1939 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1995
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2052 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2108



 Score =  396 bits (1017), Expect = e-109
 Identities = 299/958 (31%), Positives = 475/958 (49%), Gaps = 126/958 (13%)

Query: 16  RGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVAS-SIDRNEMLEIQVFNYSKVFS 74
           R D +A +TFRG    ++V++N  +   ++E F W +    +D+   L + V ++  +  
Sbjct: 20  RSDPVASLTFRGVKKRTKVIKNSVNPV-WNEGFEWDLKGIPLDQGSELHVVVKDHETMGR 78

Query: 75  NKLIGTFRMVLQKVVEESHVEVTDT--LIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGD 132
           N+ +G  ++ L++V+    +  +    L+D        SL ++V Y    G V  +    
Sbjct: 79  NRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPT 138

Query: 133 FLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQ 192
            L      E      + D +  G +           R    S+ S   +    S K+ P 
Sbjct: 139 PL------EPSPTLPDLDVVAGGGQS----------RAETWSLLSDSTMDTRYSGKKWPA 182

Query: 193 RPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTT-------------NVSNKRSK 239
             D     + ED        GD  +P         A TT              +  KRS 
Sbjct: 183 PTDTGGEEDTEDQG----LTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSA 238

Query: 240 PDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNE 299
           P  +   S  +P D+Q+ + VIE RQL G+N+ PVV V      K T + +  N P +NE
Sbjct: 239 PTSRKLLS-DKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNE 296

Query: 300 YFVFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAIL 359
              F+   SP  +FD+ I I+V+ S++L R+  L+G F+MDVGT+Y +P H +  KW +L
Sbjct: 297 TLFFNLFDSPGELFDEPIFITVVDSRSL-RTDALLGEFRMDVGTIYREPRHAYLRKWLLL 355

Query: 360 SDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARF 419
           SDPDD S+G +GY+K  + V+G GD      K    D++DIE NLL P GV    + A F
Sbjct: 356 SDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGV--ALRGAHF 413

Query: 420 YVKIYRAEGLPRMNTSLMANVKKAFIGEN--KDLVDPYVQVFFAGQKGKTSVQKSSYEPL 477
            +K++RAE LP+M+ ++M NVK+ F  E+  K+LVDP+V+V FAG+   + + + +  P 
Sbjct: 414 CLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQ 473

Query: 478 WNEQVVFTDLFPPLCKRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDGDK--------- 526
           WN+ +    +FP +C++M+++I D D++  ND+ + T ++ + KIS  G +         
Sbjct: 474 WNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEEEPAGAV 532

Query: 527 ------------GFLPTLGPAWVNMYGSTRNYT-LLDEHQDLNEGLGEGVSFRARLLLGL 573
                       GFLPT GP ++N+YGS R +T   D + +LN G GEGV++R RLLL L
Sbjct: 533 KPSKASDLDDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSL 592

Query: 574 AVEIVDTSN---PELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKP 630
             ++V+ S     +L +   ++VE+          +  ++ LF AF  A+M+  ++ D  
Sbjct: 593 ETKLVEHSEQKVEDLPADDILRVEKYL--------RRRKYSLFAAFYSATML--QDVDDA 642

Query: 631 ITFEVTIGNYGNEVDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPP 690
           I FEV+IGNYGN+ D    P                                   S+T  
Sbjct: 643 IQFEVSIGNYGNKFDMTCLP---------------------------------LASTTQY 669

Query: 691 MRPQVTDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIK 750
            R      +Y++LP+   KP + + S+W D   R+   N +  IAD+LE GL  +   +K
Sbjct: 670 SRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALK 729

Query: 751 TEKSYP--ERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQ 808
            + S    +  +  + +EL  GC +   L D  +  S+ T LD+   +     L  + + 
Sbjct: 730 AQCSTEDVDSLVAQLTDELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEA 786

Query: 809 ARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSK 868
           A  L  ++    +   L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+ 
Sbjct: 787 A--LALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAH 844

Query: 869 DLLFS-IVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
            +LFS       GK+C K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 845 QVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 899



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 1009
            F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 440  FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 476



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 453  DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
            DPY  V F  Q  KT V K++  P W++ ++F ++
Sbjct: 1206 DPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1240


>gi|195976762 dysferlin isoform 13 [Homo sapiens]
          Length = 2097

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1157 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1216

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1217 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1269

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 1107
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1270 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1326

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1327 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1383

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1384 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1443

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 1287
             F+  P    +PS                GG    S                      L 
Sbjct: 1444 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1468

Query: 1288 ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 1347
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1469 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1506

Query: 1348 PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 1407
              G  LE+                                                  D 
Sbjct: 1507 KCGSYLEKD------------------------------------------------FDT 1518

Query: 1408 LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 1465
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1519 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1572

Query: 1466 EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 1525
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1573 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1628

Query: 1526 IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 1585
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1629 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1688

Query: 1586 SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 1645
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1689 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1746

Query: 1646 PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1702
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1747 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1798

Query: 1703 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1762
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1799 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1857

Query: 1763 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1822
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1858 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1917

Query: 1823 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1881
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1918 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1977

Query: 1882 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1938
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1978 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2036

Query: 1939 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1995
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2037 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2093



 Score =  392 bits (1007), Expect = e-108
 Identities = 295/942 (31%), Positives = 469/942 (49%), Gaps = 112/942 (11%)

Query: 18  DRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVAS-SIDRNEMLEIQVFNYSKVFSNK 76
           D      F G    ++V++N  +   ++E F W +    +D+   L + V ++  +  N+
Sbjct: 21  DAYCSAVFAGVKKRTKVIKNSVNPV-WNEGFEWDLKGIPLDQGSELHVVVKDHETMGRNR 79

Query: 77  LIGTFRMVLQKVVEESHVEVTDT--LIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFL 134
            +G  ++ L++V+    +  +    L+D        SL ++V Y    G V  +     L
Sbjct: 80  FLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPTPL 139

Query: 135 GDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRP 194
                 E      + D +  G +           R    S+ S   +    S K+ P   
Sbjct: 140 ------EPSPTLPDLDVVAGGGQS----------RAETWSLLSDSTMDTRYSGKKWPAPT 183

Query: 195 DEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTT-------------NVSNKRSKPD 241
           D     + ED        GD  +P         A TT              +  KRS P 
Sbjct: 184 DTGGEEDTEDQG----LTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT 239

Query: 242 IKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYF 301
            +   S  +P D+Q+ + VIE RQL G+N+ PVV V      K T + +  N P +NE  
Sbjct: 240 SRKLLS-DKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETL 297

Query: 302 VFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSD 361
            F+   SP  +FD+ I I+V+ S++L R+  L+G F+MDVGT+Y +P H +  KW +LSD
Sbjct: 298 FFNLFDSPGELFDEPIFITVVDSRSL-RTDALLGEFRMDVGTIYREPRHAYLRKWLLLSD 356

Query: 362 PDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYV 421
           PDD S+G +GY+K  + V+G GD      K    D++DIE NLL P GV    + A F +
Sbjct: 357 PDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGV--ALRGAHFCL 414

Query: 422 KIYRAEGLPRMNTSLMANVKKAFIGEN--KDLVDPYVQVFFAGQKGKTSVQKSSYEPLWN 479
           K++RAE LP+M+ ++M NVK+ F  E+  K+LVDP+V+V FAG+   + + + +  P WN
Sbjct: 415 KVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWN 474

Query: 480 EQVVFTDLFPPLCKRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDGDK-------GFLP 530
           + +    +FP +C++M+++I D D++  ND+ + T ++ + KIS  G +       GFLP
Sbjct: 475 QNITLPAMFPSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGFLP 533

Query: 531 TLGPAWVNMYGSTRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSN---PELT 586
           T GP ++N+YGS R +T   D + +LN G GEGV++R RLLL L  ++V+ S     +L 
Sbjct: 534 TFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLP 593

Query: 587 SSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDG 646
           +   ++VE+          +  ++ LF AF  A+M+  ++ D  I FEV+IGNYGN+ D 
Sbjct: 594 ADDILRVEKYL--------RRRKYSLFAAFYSATML--QDVDDAIQFEVSIGNYGNKFDM 643

Query: 647 LSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYL 706
              P                                   S+T   R      +Y++LP+ 
Sbjct: 644 TCLP---------------------------------LASTTQYSRAVFDGCHYYYLPWG 670

Query: 707 ERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYP--ERRLRGVL 764
             KP + + S+W D   R+   N +  IAD+LE GL  +   +K + S    +  +  + 
Sbjct: 671 NVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLT 730

Query: 765 EELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDK 824
           +EL  GC +   L D  +  S+ T LD+   +     L  + + A  L  ++    +   
Sbjct: 731 DELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAA--LALKLGHSELPAA 785

Query: 825 LRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDC 883
           L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C
Sbjct: 786 LEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNC 845

Query: 884 AKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
            K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 846 GKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 884



 Score = 35.4 bits (80), Expect = 0.56
 Identities = 15/31 (48%), Positives = 19/31 (61%)

Query: 450 DLVDPYVQVFFAGQKGKTSVQKSSYEPLWNE 480
           D+ D Y    FAG K +T V K+S  P+WNE
Sbjct: 18  DISDAYCSAVFAGVKKRTKVIKNSVNPVWNE 48



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 1009
            F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 439  FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 475



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 453  DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
            DPY  V F  Q  KT V K++  P W++ ++F ++
Sbjct: 1191 DPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1225


>gi|195976760 dysferlin isoform 12 [Homo sapiens]
          Length = 2111

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1171 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1230

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1231 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1283

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 1107
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1284 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1340

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1341 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1397

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1398 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1457

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 1287
             F+  P    +PS                GG    S                      L 
Sbjct: 1458 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1482

Query: 1288 ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 1347
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1483 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1520

Query: 1348 PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 1407
              G  LE+                                                  D 
Sbjct: 1521 KCGSYLEKD------------------------------------------------FDT 1532

Query: 1408 LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 1465
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1533 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1586

Query: 1466 EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 1525
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1587 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1642

Query: 1526 IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 1585
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1643 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1702

Query: 1586 SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 1645
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1703 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1760

Query: 1646 PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1702
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1761 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1812

Query: 1703 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1762
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1813 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1871

Query: 1763 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1822
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1872 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1931

Query: 1823 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1881
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1932 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1991

Query: 1882 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1938
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1992 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2050

Query: 1939 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1995
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2051 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2107



 Score =  387 bits (993), Expect = e-107
 Identities = 295/956 (30%), Positives = 469/956 (49%), Gaps = 126/956 (13%)

Query: 18  DRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVAS-SIDRNEMLEIQVFNYSKVFSNK 76
           D      F G    ++V++N  +   ++E F W +    +D+   L + V ++  +  N+
Sbjct: 21  DAYCSAVFAGVKKRTKVIKNSVNPV-WNEGFEWDLKGIPLDQGSELHVVVKDHETMGRNR 79

Query: 77  LIGTFRMVLQKVVEESHVEVTDT--LIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFL 134
            +G  ++ L++V+    +  +    L+D        SL ++V Y    G V  +     L
Sbjct: 80  FLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPTPL 139

Query: 135 GDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRP 194
                 E      + D +  G +           R    S+ S   +    S K+ P   
Sbjct: 140 ------EPSPTLPDLDVVAGGGQS----------RAETWSLLSDSTMDTRYSGKKWPAPT 183

Query: 195 DEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTT-------------NVSNKRSKPD 241
           D     + ED        GD  +P         A TT              +  KRS P 
Sbjct: 184 DTGGEEDTEDQG----LTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT 239

Query: 242 IKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYF 301
            +   S  +P D+Q+ + VIE RQL G+N+ PVV V      K T + +  N P +NE  
Sbjct: 240 SRKLLS-DKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETL 297

Query: 302 VFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSD 361
            F+   SP  +FD+ I I+V+ S++L R+  L+G F+MDVGT+Y +P H +  KW +LSD
Sbjct: 298 FFNLFDSPGELFDEPIFITVVDSRSL-RTDALLGEFRMDVGTIYREPRHAYLRKWLLLSD 356

Query: 362 PDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYV 421
           PDD S+G +GY+K  + V+G GD      K    D++DIE NLL P GV    + A F +
Sbjct: 357 PDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGV--ALRGAHFCL 414

Query: 422 KIYRAEGLPRMNTSLMANVKKAFIGEN--KDLVDPYVQVFFAGQKGKTSVQKSSYEPLWN 479
           K++RAE LP+M+ ++M NVK+ F  E+  K+LVDP+V+V FAG+   + + + +  P WN
Sbjct: 415 KVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWN 474

Query: 480 EQVVFTDLFPPLCKRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDGDK----------- 526
           + +    +FP +C++M+++I D D++  ND+ + T ++ + KIS  G +           
Sbjct: 475 QNITLPAMFPSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEEEPAGAVKP 533

Query: 527 ----------GFLPTLGPAWVNMYGSTRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAV 575
                     GFLPT GP ++N+YGS R +T   D + +LN G GEGV++R RLLL L  
Sbjct: 534 SKASDLDDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLET 593

Query: 576 EIVDTSN---PELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPIT 632
           ++V+ S     +L +   ++VE+          +  ++ LF AF  A+M+  ++ D  I 
Sbjct: 594 KLVEHSEQKVEDLPADDILRVEKYL--------RRRKYSLFAAFYSATML--QDVDDAIQ 643

Query: 633 FEVTIGNYGNEVDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMR 692
           FEV+IGNYGN+ D    P                                   S+T   R
Sbjct: 644 FEVSIGNYGNKFDMTCLP---------------------------------LASTTQYSR 670

Query: 693 PQVTDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTE 752
                 +Y++LP+   KP + + S+W D   R+   N +  IAD+LE GL  +   +K +
Sbjct: 671 AVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQ 730

Query: 753 KSYP--ERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQAR 810
            S    +  +  + +EL  GC +   L D  +  S+ T LD+   +     L  + + A 
Sbjct: 731 CSTEDVDSLVAQLTDELIAGCSQ--PLGDIHETPSA-THLDQYLYQLRTHHLSQITEAA- 786

Query: 811 MLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDL 870
            L  ++    +   L   +++L +LR LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +
Sbjct: 787 -LALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQV 845

Query: 871 LFS-IVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
           LFS       GK+C K++T+FLK P ++  G A   VQ +V+  LW GLS   KEF
Sbjct: 846 LFSRRGANYCGKNCGKLQTIFLKYPMEKVPG-ARMPVQIRVK--LWFGLSVDEKEF 898



 Score = 35.4 bits (80), Expect = 0.56
 Identities = 15/31 (48%), Positives = 19/31 (61%)

Query: 450 DLVDPYVQVFFAGQKGKTSVQKSSYEPLWNE 480
           D+ D Y    FAG K +T V K+S  P+WNE
Sbjct: 18  DISDAYCSAVFAGVKKRTKVIKNSVNPVWNE 48



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 1009
            F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 439  FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 475



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 453  DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
            DPY  V F  Q  KT V K++  P W++ ++F ++
Sbjct: 1205 DPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1239


>gi|195976754 dysferlin isoform 9 [Homo sapiens]
          Length = 2066

 Score =  712 bits (1839), Expect = 0.0
 Identities = 410/1077 (38%), Positives = 584/1077 (54%), Gaps = 169/1077 (15%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P +S ++     + LR +MYQAR L A D    SDP+A V F++QSQ T V+  TL PTW
Sbjct: 1126 PTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTW 1185

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ L+F  +E++GE   + + PP IV+E+YD D+ G  +FMGR   +P ++         
Sbjct: 1186 DQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERM------- 1238

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQ--------------------IGPAGKADLPP 1107
               P+L ++ + RG+  +G+LLA+FEL+Q                    +  +   DLP 
Sbjct: 1239 ---PRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPY 1295

Query: 1108 INGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGV 1167
               P       I  VP  I+P L +  +E+L WGLR++K   LA +  P + +EC G+ V
Sbjct: 1296 ---PPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTV 1352

Query: 1168 QSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLR 1227
            QS +I N +KNPNF+    + EV LP  EL  PP+ ++V+D R FGR  +VG   + SL 
Sbjct: 1353 QSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLE 1412

Query: 1228 RFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLD 1287
             F+  P    +PS                GG    S                      L 
Sbjct: 1413 SFLCDPYSAESPS--------------PQGGPDDVSL---------------------LS 1437

Query: 1288 ATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQE 1347
               + ++ +D                +EP     +E  +DWWSK+FASI        ++E
Sbjct: 1438 PGEDVLIDID---------------DKEPLIPIQEEEFIDWWSKFFASIG-------ERE 1475

Query: 1348 PSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDE 1407
              G  LE+                                                  D 
Sbjct: 1476 KCGSYLEKD------------------------------------------------FDT 1487

Query: 1408 LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 1465
            LKVY  +LE+   F+   D+ +TF L RGKT ++    TE+  ++G FKG   +Y  PLP
Sbjct: 1488 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE----TEDPSVIGEFKGLFKIY--PLP 1541

Query: 1466 EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 1525
            ED +           F  + +  P   LVR+Y+VRA  L P D NGK DPYI I +GK  
Sbjct: 1542 EDPA----IPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKS 1597

Query: 1526 IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 1585
            + D++NYI   L PVFGK F++  + P+E  L + +YD+DL+  D+ IGET +DLENR  
Sbjct: 1598 VSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL 1657

Query: 1586 SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 1645
            SK  A CG+ QTY   G N WRD ++PSQ+L   C+  +V  P +    RV   ++ ++ 
Sbjct: 1658 SKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD-RVMFQDKEYS- 1715

Query: 1646 PSEIED---ENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQG 1702
              EIE     N    P +E +AL  L+           LVPEHVE+RPL +P +P IEQG
Sbjct: 1716 IEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQPDIEQG 1767

Query: 1703 RLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFV 1762
            +L++WVD+FP  +  PG P +I+PR+ +++ LR IIWNT +V+L DD   TGEK SDI+V
Sbjct: 1768 KLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVIL-DDLSLTGEKMSDIYV 1826

Query: 1763 RGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEY 1822
            +GW+ G +E KQ TDVHY SL GEGNFNWR++FPFDYL AE+   I+KK++ +  D+TE 
Sbjct: 1827 KGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTES 1886

Query: 1823 KIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVP-LVSIF 1881
            KIPAR+  QIWD D FS DDFLG+++LDLNR P+ AKTAK+C+++           VS+F
Sbjct: 1887 KIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLF 1946

Query: 1882 KQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPN 1938
            +QK VKGWWP +A  E ++  L GK+E  L ++   E E+ P G  R+EP+    LE P 
Sbjct: 1947 EQKTVKGWWPCVA-EEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPR 2005

Query: 1939 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1995
            RPDTSF+WF +P K+ ++ LW  +RW ++  ++L +LLL LA+F+Y+ P Y   K++
Sbjct: 2006 RPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLV 2062



 Score =  387 bits (994), Expect = e-107
 Identities = 289/929 (31%), Positives = 458/929 (49%), Gaps = 117/929 (12%)

Query: 18  DRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVAS-SIDRNEMLEIQVFNYSKVFSNK 76
           D      F G    ++V++N  +   ++E F W +    +D+   L + V ++  +  N+
Sbjct: 21  DAYCSAVFAGVKKRTKVIKNSVNPV-WNEGFEWDLKGIPLDQGSELHVVVKDHETMGRNR 79

Query: 77  LIGTFRMVLQKVVEESHVEVTDT--LIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFL 134
            +G  ++ L++V+    +  +    L+D        SL ++V Y    G V  +     L
Sbjct: 80  FLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPTPL 139

Query: 135 GDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRP 194
                        E    LP     +   GE+     G +   A            P  P
Sbjct: 140 -------------EPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPF---LDQSGGPGAP 183

Query: 195 DEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDY 254
             P  L      H                         +  KRS P  +   S  +P D+
Sbjct: 184 TTPRKLPSRPPPHYP----------------------GIKRKRSAPTSRKLLS-DKPQDF 220

Query: 255 QVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFD 314
           Q+ + VIE RQL G+N+ PVV V      K T + +  N P +NE   F+   SP  +FD
Sbjct: 221 QIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSPGELFD 279

Query: 315 KIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGYVK 374
           + I I+V+ S++L R+  L+G F+MDVGT+Y +P H +  KW +LSDPDD S+G +GY+K
Sbjct: 280 EPIFITVVDSRSL-RTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLK 338

Query: 375 CDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEGLPRMNT 434
             + V+G GD      K    D++DIE NLL P GV    + A F +K++RAE LP+M+ 
Sbjct: 339 TSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGV--ALRGAHFCLKVFRAEDLPQMDD 396

Query: 435 SLMANVKKAFIGEN--KDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLC 492
           ++M NVK+ F  E+  K+LVDP+V+V FAG+   + + + +  P WN+ +    +FP +C
Sbjct: 397 AVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMC 456

Query: 493 KRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDGDK-------GFLPTLGPAWVNMYGST 543
           ++M+++I D D++  ND+ + T ++ + KIS  G +       GFLPT GP ++N+YGS 
Sbjct: 457 EKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCYINLYGSP 515

Query: 544 RNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSN---PELTSSTEVQVEQATPI 599
           R +T   D + +LN G GEGV++R RLLL L  ++V+ S     +L +   ++VE+    
Sbjct: 516 REFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILRVEKYL-- 573

Query: 600 SESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDGLSRPQRPRPRKEP 659
                 +  ++ LF AF  A+M+  ++ D  I FEV+IGNYGN+ D    P         
Sbjct: 574 ------RRRKYSLFAAFYSATML--QDVDDAIQFEVSIGNYGNKFDMTCLP--------- 616

Query: 660 GDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKPCIYIKSWWP 719
                                     S+T   R      +Y++LP+   KP + + S+W 
Sbjct: 617 ------------------------LASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWE 652

Query: 720 DQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYP--ERRLRGVLEELSCGCCRFLSL 777
           D   R+   N +  IAD+LE GL  +   +K + S    +  +  + +EL  GC +   L
Sbjct: 653 DISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQ--PL 710

Query: 778 ADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRF 837
            D  +  S+ T LD+   +     L  + + A  L  ++    +   L   +++L +LR 
Sbjct: 711 GDIHETPSA-THLDQYLYQLRTHHLSQITEAA--LALKLGHSELPAALEQAEDWLLRLRA 767

Query: 838 LADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFS-IVEEETGKDCAKVKTLFLKLPGK 896
           LA+EPQ+S+PDI IWM+  +KRVAY RVP+  +LFS       GK+C K++T+FLK P +
Sbjct: 768 LAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPME 827

Query: 897 RGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
           +  G A   VQ +V+  LW GLS   KEF
Sbjct: 828 KVPG-ARMPVQIRVK--LWFGLSVDEKEF 853



 Score = 35.4 bits (80), Expect = 0.56
 Identities = 15/31 (48%), Positives = 19/31 (61%)

Query: 450 DLVDPYVQVFFAGQKGKTSVQKSSYEPLWNE 480
           D+ D Y    FAG K +T V K+S  P+WNE
Sbjct: 18  DISDAYCSAVFAGVKKRTKVIKNSVNPVWNE 48



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 973  FAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQ 1009
            F ++   L DPF  V F  +  C+++L +T  P W+Q
Sbjct: 408  FESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 444



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 453  DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDL 487
            DPY  V F  Q  KT V K++  P W++ ++F ++
Sbjct: 1160 DPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1194


>gi|19718759 myoferlin isoform b [Homo sapiens]
          Length = 2048

 Score =  684 bits (1764), Expect = 0.0
 Identities = 395/1062 (37%), Positives = 580/1062 (54%), Gaps = 145/1062 (13%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P VS  + +   + LR ++YQAR+L A D    SDP+A + F+++S+ TE+++ TL PTW
Sbjct: 1114 PIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTW 1173

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ ++FD +E+YGE   +  +PP +++E++D D +GK +F+GR+   P+VK+  E     
Sbjct: 1174 DQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM---- 1229

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK--ADLPPINGPVDVDRGPIMPVPMG 1125
               P+L ++ +  G+   GD+L   EL+  G  G     LPP   P       +  VP G
Sbjct: 1230 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAP------NLYMVPQG 1283

Query: 1126 IRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLV 1185
            IRPV+    +E+L WGLR++K   +A +  P + +EC G+ V+S +I N KK PNF + V
Sbjct: 1284 IRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSV 1343

Query: 1186 KWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF---IYRPPDRSAPSWN 1242
             + +V LP+ EL  PPL I+V+D R FGR  +VG   +  L RF    Y   +   P   
Sbjct: 1344 LFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLK 1403

Query: 1243 TTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEE 1302
             ++     CR             ++V+ ME   P+                    +A + 
Sbjct: 1404 ASLLSAPPCR-------------DIVIEMEDTKPL--------------------LASKL 1430

Query: 1303 KEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNT 1362
             EK                +E ++DWWSK++AS         + E  G  ++        
Sbjct: 1431 TEK----------------EEEIVDWWSKFYASSG-------EHEKCGQYIQ-------- 1459

Query: 1363 EGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNF 1422
                   KG  K +    E +   +  G                              +F
Sbjct: 1460 -------KGYSKLKIYNCELENVAEFEG----------------------------LTDF 1484

Query: 1423 EDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQ 1482
             D   TF L RGK+ ++ED S     +VG FKGS  +Y  PLP+D S  A        F+
Sbjct: 1485 SD---TFKLYRGKSDENEDPS-----VVGEFKGSFRIY--PLPDDPSVPA----PPRQFR 1530

Query: 1483 GIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFG 1542
             +P + P    VR+Y+VR  +L P D NG  DPYI I LGK  I D+++YI   LNPVFG
Sbjct: 1531 ELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFG 1590

Query: 1543 KSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 1602
            + +++    P E  L ++VYD+D    D+ +GET IDLENRF S+  + CGI + Y   G
Sbjct: 1591 RMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSG 1650

Query: 1603 YNIWRDPMKPSQILTRLCKDGKVDGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDE 1661
             N WRD ++P+Q+L  + +      P     G R++   R ++      DE    K   +
Sbjct: 1651 VNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYS-----LDEFEANKILHQ 1705

Query: 1662 HVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTP 1721
            H+     R    I R    LVPEHVETR L +  +P I QG+L++WVD+FP  +  PG P
Sbjct: 1706 HLGAPEERLALHILRTQ-GLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPP 1764

Query: 1722 LDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYH 1781
             +I+PRK KKY LRVIIWNT +V+L D+   TGE+ SDI+V+GW+ G +E+KQ TDVHY 
Sbjct: 1765 FNITPRKAKKYYLRVIIWNTKDVIL-DEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYR 1823

Query: 1782 SLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSAD 1841
            SL GEGNFNWR++FPFDYL AE+  +++KKE  +S D+TE++IP RL +QIWD D FS D
Sbjct: 1824 SLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLD 1883

Query: 1842 DFLGAIELDLNRFPRGAKTAKQCTMEM-----ATGEVDVPLVSIFKQKRVKGWWPLLARN 1896
            D+LG +ELDL      AK+ ++C ++M     A   +     S+F+QK +KGWWP  A  
Sbjct: 1884 DYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEK 1943

Query: 1897 ENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTSFIWFLNPLKS 1953
            +     + GKVE  L +L  +EA++ P G  R+EP+    L+ PNRP+TSF+WF NP K+
Sbjct: 1944 DGARV-MAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKT 2002

Query: 1954 ARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1995
             ++ +W  ++W+++ LL LL+LLL +A+ LYS+P YL  KI+
Sbjct: 2003 MKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIV 2044



 Score =  365 bits (938), Expect = e-100
 Identities = 286/941 (30%), Positives = 457/941 (48%), Gaps = 152/941 (16%)

Query: 15  GRGDRIAKVTFRGQSFYSRVLEN-----CEDVADFDETFRWPVASSIDRNEMLEIQVFNY 69
           G+ D I  V F+ +   ++ ++N       ++ +FD          +D +  L I V ++
Sbjct: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLR-----GIPLDFSSSLGIIVKDF 72

Query: 70  SKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWD 129
             +  NKLIGT  + L+ +  +    +   LI                            
Sbjct: 73  ETIGQNKLIGTATVALKDLTGDQSRSLPYKLIS--------------------------- 105

Query: 130 DGDFLGDESLQEEEKDSQETDGLLPGSRPSSRP-PGEKSFRRAGRSVFSAMKLGKNRSHK 188
                    L E+ +D+  T  L+ G  P S P P + S    G SV             
Sbjct: 106 --------LLNEKGQDTGATIDLVIGYDPPSAPHPNDLS----GPSV-------PGMGGD 146

Query: 189 EEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSA 248
            E    DE      + LD+     G      +VS A +    T V N R          +
Sbjct: 147 GEEDEGDE------DRLDNAVRGPGPKGPVGTVSEAQLARRLTKVKNSRRM-------LS 193

Query: 249 GRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVS 308
            +P D+Q+ + VIE RQL G N+ PVV V V      T +K   N P+++E F ++ +++
Sbjct: 194 NKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNN-PFFDELFFYNVNMT 252

Query: 309 PDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSG 368
           P  + D+II I V +S +L R+  L+G FK+DVG VY +P H    KW +L+DP+D SSG
Sbjct: 253 PSELMDEIISIRVYNSHSL-RADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSG 311

Query: 369 LKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEG 428
            KGY+K  + V+G GD      +  + D DD+E NLLLP G+    +W  F +KIYRAE 
Sbjct: 312 SKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGI--ALRWVTFLLKIYRAED 369

Query: 429 LPRMNTSLMANVKKAFIG--ENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTD 486
           +P+M+ +    VK+ F G  + K+LVDP+V+V FAG+K  T++ + +  P WN+ V    
Sbjct: 370 IPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQI 429

Query: 487 LFPPLCKRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDG----------DKGFLPTLGP 534
            FP +C+++K+ I D D++  NDV +GT ++ L KI+  G          + GF+PT GP
Sbjct: 430 KFPSVCEKIKLTIYDWDRLTKNDV-VGTTYLHLSKIAASGGEVEVNTGETEVGFVPTFGP 488

Query: 535 AWVNMYGSTRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDT---SNPELTSSTE 590
            ++N+YGS R YT   D + +LN G GEGV++R R+L+ LA  +  T      E  S+ +
Sbjct: 489 CYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDD 548

Query: 591 VQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDGLSRP 650
           + V +          +  ++ L   F  A+M+  ++  + I FEV+IGNYGN+ D   +P
Sbjct: 549 LLVVEKYQ-------RRRKYSLSAVFHSATML--QDVGEAIQFEVSIGNYGNKFDTTCKP 599

Query: 651 QRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRN-YFHLPYLERK 709
                                             ++ST      V D N Y++LP+   K
Sbjct: 600 ----------------------------------LASTTQYSRAVFDGNYYYYLPWAHTK 625

Query: 710 PCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLR----GVLE 765
           P + + S+W D   RL   N +  +A++L+  +  ++  I  +   P  +L      +++
Sbjct: 626 PVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGI--QGKIPANQLAELWLKLID 683

Query: 766 ELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKL 825
           E+       L L    +G ++ T LD +  K   R L  + + A  +R++     V+  L
Sbjct: 684 EVIEDTRYTLPLT---EGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEAT--DVKSTL 738

Query: 826 RLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIV-EEETGKDCA 884
              +++L KL  L +EPQ+S+PDI IWM+   KR+AYAR+P+  +L+S   E  +GK C 
Sbjct: 739 AEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCG 798

Query: 885 KVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
           K +T+FLK P ++  G     V  ++ + +WLGLS   K+F
Sbjct: 799 KTQTIFLKYPQEKNNGP---KVPVELRVNIWLGLSAVEKKF 836



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 8/78 (10%)

Query: 975  ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 1034
            AD   L DPF  V F  +  CT ++ +   P W+Q++   NL++     +       I +
Sbjct: 389  ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV---NLQI-----KFPSVCEKIKL 440

Query: 1035 EIYDQDSMGKADFMGRTF 1052
             IYD D + K D +G T+
Sbjct: 441  TIYDWDRLTKNDVVGTTY 458



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 3/75 (4%)

Query: 1507 ADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPME-SMLTVAVYDWD 1565
            AD     DP++ +      +    N I K  NP + +  +++  FP     + + +YDWD
Sbjct: 389  ADKKNLVDPFVEVSFAGKKVCT--NIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWD 446

Query: 1566 LVGTDDLIGETKIDL 1580
             +  +D++G T + L
Sbjct: 447  RLTKNDVVGTTYLHL 461



 Score = 33.5 bits (75), Expect = 2.1
 Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 7/89 (7%)

Query: 438 ANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPL--CKRM 495
           +N+ K   G+     DP V V F  +K KT    +   P+WNE + F     PL     +
Sbjct: 10  SNIPKTKFGKP----DPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDFSSSL 65

Query: 496 KVQIRDSDKV-NDVAIGTHFIDLRKISND 523
            + ++D + +  +  IGT  + L+ ++ D
Sbjct: 66  GIIVKDFETIGQNKLIGTATVALKDLTGD 94



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 1486 SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 1545
            SN P +  +RV V+    L   +I      ++  +  +T I+   N    +L   F  + 
Sbjct: 193  SNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDEL---FFYNV 249

Query: 1546 DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDL 1580
            ++  S  M+ ++++ VY+   +  D L+GE KID+
Sbjct: 250  NMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV 284


>gi|7305053 myoferlin isoform a [Homo sapiens]
          Length = 2061

 Score =  684 bits (1764), Expect = 0.0
 Identities = 395/1062 (37%), Positives = 580/1062 (54%), Gaps = 145/1062 (13%)

Query: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007
            P VS  + +   + LR ++YQAR+L A D    SDP+A + F+++S+ TE+++ TL PTW
Sbjct: 1127 PIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTW 1186

Query: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067
            DQ ++FD +E+YGE   +  +PP +++E++D D +GK +F+GR+   P+VK+  E     
Sbjct: 1187 DQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM---- 1242

Query: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK--ADLPPINGPVDVDRGPIMPVPMG 1125
               P+L ++ +  G+   GD+L   EL+  G  G     LPP   P       +  VP G
Sbjct: 1243 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAP------NLYMVPQG 1296

Query: 1126 IRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLV 1185
            IRPV+    +E+L WGLR++K   +A +  P + +EC G+ V+S +I N KK PNF + V
Sbjct: 1297 IRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSV 1356

Query: 1186 KWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF---IYRPPDRSAPSWN 1242
             + +V LP+ EL  PPL I+V+D R FGR  +VG   +  L RF    Y   +   P   
Sbjct: 1357 LFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLK 1416

Query: 1243 TTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEE 1302
             ++     CR             ++V+ ME   P+                    +A + 
Sbjct: 1417 ASLLSAPPCR-------------DIVIEMEDTKPL--------------------LASKL 1443

Query: 1303 KEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNT 1362
             EK                +E ++DWWSK++AS         + E  G  ++        
Sbjct: 1444 TEK----------------EEEIVDWWSKFYASSG-------EHEKCGQYIQ-------- 1472

Query: 1363 EGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNF 1422
                   KG  K +    E +   +  G                              +F
Sbjct: 1473 -------KGYSKLKIYNCELENVAEFEG----------------------------LTDF 1497

Query: 1423 EDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQ 1482
             D   TF L RGK+ ++ED S     +VG FKGS  +Y  PLP+D S  A        F+
Sbjct: 1498 SD---TFKLYRGKSDENEDPS-----VVGEFKGSFRIY--PLPDDPSVPA----PPRQFR 1543

Query: 1483 GIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFG 1542
             +P + P    VR+Y+VR  +L P D NG  DPYI I LGK  I D+++YI   LNPVFG
Sbjct: 1544 ELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFG 1603

Query: 1543 KSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 1602
            + +++    P E  L ++VYD+D    D+ +GET IDLENRF S+  + CGI + Y   G
Sbjct: 1604 RMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSG 1663

Query: 1603 YNIWRDPMKPSQILTRLCKDGKVDGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDE 1661
             N WRD ++P+Q+L  + +      P     G R++   R ++      DE    K   +
Sbjct: 1664 VNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYS-----LDEFEANKILHQ 1718

Query: 1662 HVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTP 1721
            H+     R    I R    LVPEHVETR L +  +P I QG+L++WVD+FP  +  PG P
Sbjct: 1719 HLGAPEERLALHILRTQ-GLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPP 1777

Query: 1722 LDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYH 1781
             +I+PRK KKY LRVIIWNT +V+L D+   TGE+ SDI+V+GW+ G +E+KQ TDVHY 
Sbjct: 1778 FNITPRKAKKYYLRVIIWNTKDVIL-DEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYR 1836

Query: 1782 SLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSAD 1841
            SL GEGNFNWR++FPFDYL AE+  +++KKE  +S D+TE++IP RL +QIWD D FS D
Sbjct: 1837 SLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLD 1896

Query: 1842 DFLGAIELDLNRFPRGAKTAKQCTMEM-----ATGEVDVPLVSIFKQKRVKGWWPLLARN 1896
            D+LG +ELDL      AK+ ++C ++M     A   +     S+F+QK +KGWWP  A  
Sbjct: 1897 DYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEK 1956

Query: 1897 ENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTSFIWFLNPLKS 1953
            +     + GKVE  L +L  +EA++ P G  R+EP+    L+ PNRP+TSF+WF NP K+
Sbjct: 1957 DGARV-MAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKT 2015

Query: 1954 ARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1995
             ++ +W  ++W+++ LL LL+LLL +A+ LYS+P YL  KI+
Sbjct: 2016 MKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIV 2057



 Score =  360 bits (925), Expect = 6e-99
 Identities = 286/954 (29%), Positives = 457/954 (47%), Gaps = 165/954 (17%)

Query: 15  GRGDRIAKVTFRGQSFYSRVLEN-----CEDVADFDETFRWPVASSIDRNEMLEIQVFNY 69
           G+ D I  V F+ +   ++ ++N       ++ +FD          +D +  L I V ++
Sbjct: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLR-----GIPLDFSSSLGIIVKDF 72

Query: 70  SKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWD 129
             +  NKLIGT  + L+ +  +    +   LI                            
Sbjct: 73  ETIGQNKLIGTATVALKDLTGDQSRSLPYKLIS--------------------------- 105

Query: 130 DGDFLGDESLQEEEKDSQETDGLLPGSRPSSRP-PGEKSFRRAGRSVFSAMKLGKNRSHK 188
                    L E+ +D+  T  L+ G  P S P P + S    G SV             
Sbjct: 106 --------LLNEKGQDTGATIDLVIGYDPPSAPHPNDLS----GPSV-------PGMGGD 146

Query: 189 EEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSA 248
            E    DE      + LD+     G      +VS A +    T V N R          +
Sbjct: 147 GEEDEGDE------DRLDNAVRGPGPKGPVGTVSEAQLARRLTKVKNSRRM-------LS 193

Query: 249 GRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVS 308
            +P D+Q+ + VIE RQL G N+ PVV V V      T +K   N P+++E F ++ +++
Sbjct: 194 NKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNN-PFFDELFFYNVNMT 252

Query: 309 PDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSG 368
           P  + D+II I V +S +L R+  L+G FK+DVG VY +P H    KW +L+DP+D SSG
Sbjct: 253 PSELMDEIISIRVYNSHSL-RADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSG 311

Query: 369 LKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEG 428
            KGY+K  + V+G GD      +  + D DD+E NLLLP G+    +W  F +KIYRAE 
Sbjct: 312 SKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGI--ALRWVTFLLKIYRAED 369

Query: 429 LPRMNTSLMANVKKAFIG--ENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTD 486
           +P+M+ +    VK+ F G  + K+LVDP+V+V FAG+K  T++ + +  P WN+ V    
Sbjct: 370 IPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQI 429

Query: 487 LFPPLCKRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDG-------------------- 524
            FP +C+++K+ I D D++  NDV +GT ++ L KI+  G                    
Sbjct: 430 KFPSVCEKIKLTIYDWDRLTKNDV-VGTTYLHLSKIAASGGEVEDFSSSGTGAASYTVNT 488

Query: 525 ---DKGFLPTLGPAWVNMYGSTRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDT 580
              + GF+PT GP ++N+YGS R YT   D + +LN G GEGV++R R+L+ LA  +  T
Sbjct: 489 GETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKT 548

Query: 581 ---SNPELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTI 637
                 E  S+ ++ V +          +  ++ L   F  A+M+  ++  + I FEV+I
Sbjct: 549 PPDKKLEPISNDDLLVVEKYQ-------RRRKYSLSAVFHSATML--QDVGEAIQFEVSI 599

Query: 638 GNYGNEVDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTD 697
           GNYGN+ D   +P                                  ++ST      V D
Sbjct: 600 GNYGNKFDTTCKP----------------------------------LASTTQYSRAVFD 625

Query: 698 RN-YFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYP 756
            N Y++LP+   KP + + S+W D   RL   N +  +A++L+  +  ++  I  +   P
Sbjct: 626 GNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGI--QGKIP 683

Query: 757 ERRLR----GVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARML 812
             +L      +++E+       L L    +G ++ T LD +  K   R L  + + A  +
Sbjct: 684 ANQLAELWLKLIDEVIEDTRYTLPLT---EGKANVTVLDTQIRKLRSRSLSQIHEAAVRM 740

Query: 813 RAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLF 872
           R++     V+  L   +++L KL  L +EPQ+S+PDI IWM+   KR+AYAR+P+  +L+
Sbjct: 741 RSEAT--DVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLY 798

Query: 873 SIV-EEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925
           S   E  +GK C K +T+FLK P ++  G     V  ++ + +WLGLS   K+F
Sbjct: 799 STSGENASGKYCGKTQTIFLKYPQEKNNGP---KVPVELRVNIWLGLSAVEKKF 849



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 8/78 (10%)

Query: 975  ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 1034
            AD   L DPF  V F  +  CT ++ +   P W+Q++   NL++     +       I +
Sbjct: 389  ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV---NLQI-----KFPSVCEKIKL 440

Query: 1035 EIYDQDSMGKADFMGRTF 1052
             IYD D + K D +G T+
Sbjct: 441  TIYDWDRLTKNDVVGTTY 458



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 25/97 (25%), Positives = 46/97 (47%), Gaps = 8/97 (8%)

Query: 1507 ADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPME-SMLTVAVYDWD 1565
            AD     DP++ +      +    N I K  NP + +  +++  FP     + + +YDWD
Sbjct: 389  ADKKNLVDPFVEVSFAGKKVCT--NIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWD 446

Query: 1566 LVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 1602
             +  +D++G T + L     SK  A+ G  + +S+ G
Sbjct: 447  RLTKNDVVGTTYLHL-----SKIAASGGEVEDFSSSG 478



 Score = 33.5 bits (75), Expect = 2.1
 Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 7/89 (7%)

Query: 438 ANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPL--CKRM 495
           +N+ K   G+     DP V V F  +K KT    +   P+WNE + F     PL     +
Sbjct: 10  SNIPKTKFGKP----DPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDFSSSL 65

Query: 496 KVQIRDSDKV-NDVAIGTHFIDLRKISND 523
            + ++D + +  +  IGT  + L+ ++ D
Sbjct: 66  GIIVKDFETIGQNKLIGTATVALKDLTGD 94



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 1486 SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 1545
            SN P +  +RV V+    L   +I      ++  +  +T I+   N    +L   F  + 
Sbjct: 193  SNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDEL---FFYNV 249

Query: 1546 DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDL 1580
            ++  S  M+ ++++ VY+   +  D L+GE KID+
Sbjct: 250  NMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV 284


>gi|116642865 fer-1-like 5 isoform 1 [Homo sapiens]
          Length = 802

 Score =  429 bits (1102), Expect = e-119
 Identities = 244/602 (40%), Positives = 351/602 (58%), Gaps = 45/602 (7%)

Query: 1408 LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 1465
            LKVY  ELE+   F   +D+  TF L + +   D         +VG FKG   +Y  P P
Sbjct: 156  LKVYECELEAVPAFQGLQDFCQTFKLYQEQPKLDSP-------VVGEFKGLFRIY--PFP 206

Query: 1466 EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 1525
            E+   EA       +      + P   LVRVY+VRA +L P D NG  DPY+ ++LGKT+
Sbjct: 207  ENP--EAPKPPLQFLVWPEREDFPQPCLVRVYMVRAINLQPQDYNGLCDPYVILKLGKTE 264

Query: 1526 IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 1585
            + +++ Y    L+P+FG  F++  + P+E  L + +YD+DL   DD IG T IDLENR  
Sbjct: 265  LGNRDMYQPNTLDPIFGMMFELTCNIPLEKDLEIQLYDFDLFSPDDKIGTTVIDLENRLL 324

Query: 1586 SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 1645
            S   A CG++++Y   G   WRD M PS +L R  K   +  P F P       + VF  
Sbjct: 325  SGFGAHCGLSKSYCQSGPFRWRDQMPPSYLLERYAKRKGLPPPLFSPE-----EDAVFYN 379

Query: 1646 PSEIEDENGQRK--------PTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKP 1697
              + + ++ + K        P  E +AL  L H +        LVPEHVETR L +  +P
Sbjct: 380  GKKFKLQSFEPKTPTVHGLGPKKERLALYLL-HTQG-------LVPEHVETRTLYSHSQP 431

Query: 1698 GIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKS 1757
            GI+QG++++WVD+FP  +  PG  ++I+PRKPK+YELR IIW T  V L DD+  + EK+
Sbjct: 432  GIDQGKVQMWVDIFPKKLGPPGPQVNINPRKPKRYELRCIIWKTANVDLVDDNL-SREKT 490

Query: 1758 SDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSW 1817
            SDI+++GWL G ++D Q TD+HYHSLTGE +FNWR++F  DYLAAE   V S+K+ ++S 
Sbjct: 491  SDIYIKGWLYGLEKDMQKTDIHYHSLTGEADFNWRFIFTMDYLAAERTCVQSQKDYIWSL 550

Query: 1818 DETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPL 1877
            D T  K PARL +Q+WD D FS DDFLG +ELDL+  P  A+ AKQC++ M   +   P 
Sbjct: 551  DATSMKFPARLIIQVWDNDIFSPDDFLGVLELDLSDMPLPARHAKQCSIRMMDADPKWPY 610

Query: 1878 ------VSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEP 1931
                   S+FK+K V GWWP     +  ++ L+GKV+  L +L+ +EA   P G  ++EP
Sbjct: 611  FIQYKHFSLFKKKTVTGWWPCQVL-DGGKWRLSGKVKMSLEILSEKEALIKPAGRGQSEP 669

Query: 1932 D---PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPG 1988
            +    L  P R +TSF W  +P+++  Y  W  YR+ L+  +++ ++ L+L  F+YS P 
Sbjct: 670  NQYPTLHPPLRTNTSFTWLRSPVQNFCYIFWKRYRFKLIAFMVISIIALMLFNFIYSAPH 729

Query: 1989 YL 1990
            YL
Sbjct: 730  YL 731



 Score = 38.5 bits (88), Expect = 0.067
 Identities = 23/86 (26%), Positives = 44/86 (51%), Gaps = 2/86 (2%)

Query: 1150 LAQVDRPRVDIECAGKGVQSSLIHNYKKNPNF--NTLVKWFEVDLPENELLHPPLNIRVV 1207
            + +   P++ +E   + +++  I +++ NPNF  +  V    V +P  E    PL ++VV
Sbjct: 1    MKKASSPQLLVEFGEESLRTEPIRDFQTNPNFPESESVLVLTVLMPTEEAYALPLVVKVV 60

Query: 1208 DCRAFGRYTLVGSHAVSSLRRFIYRP 1233
            D  AFG+ T+ G   +  L+ +   P
Sbjct: 61   DNWAFGQQTVTGQANIDFLQPYFCDP 86


>gi|164607133 fer-1-like 5 isoform 2 [Homo sapiens]
          Length = 2093

 Score =  421 bits (1082), Expect = e-117
 Identities = 244/611 (39%), Positives = 351/611 (57%), Gaps = 54/611 (8%)

Query: 1408 LKVYPKELES--EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLP 1465
            LKVY  ELE+   F   +D+  TF L + +   D         +VG FKG   +Y  P P
Sbjct: 1438 LKVYECELEAVPAFQGLQDFCQTFKLYQEQPKLDSP-------VVGEFKGLFRIY--PFP 1488

Query: 1466 EDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTD 1525
            E+   EA       +      + P   LVRVY+VRA +L P D NG  DPY+ ++LGKT+
Sbjct: 1489 ENP--EAPKPPLQFLVWPEREDFPQPCLVRVYMVRAINLQPQDYNGLCDPYVILKLGKTE 1546

Query: 1526 IRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFY 1585
            + +++ Y    L+P+FG  F++  + P+E  L + +YD+DL   DD IG T IDLENR  
Sbjct: 1547 LGNRDMYQPNTLDPIFGMMFELTCNIPLEKDLEIQLYDFDLFSPDDKIGTTVIDLENRLL 1606

Query: 1586 SKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTG 1645
            S   A CG++++Y   G   WRD M PS +L R  K   +  P F P       + VF  
Sbjct: 1607 SGFGAHCGLSKSYCQSGPFRWRDQMPPSYLLERYAKRKGLPPPLFSPE-----EDAVFYN 1661

Query: 1646 PSEIEDENGQRK--------PTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKP 1697
              + + ++ + K        P  E +AL  L H +        LVPEHVETR L +  +P
Sbjct: 1662 GKKFKLQSFEPKTPTVHGLGPKKERLALYLL-HTQG-------LVPEHVETRTLYSHSQP 1713

Query: 1698 GIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKK---------YELRVIIWNTDEVVLED 1748
            GI+QG++++WVD+FP  +  PG  ++I+PRKPK+         YELR IIW T  V L D
Sbjct: 1714 GIDQGKVQMWVDIFPKKLGPPGPQVNINPRKPKRKASEHSGHRYELRCIIWKTANVDLVD 1773

Query: 1749 DDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVI 1808
            D+  + EK+SDI+++GWL G ++D Q TD+HYHSLTGE +FNWR++F  DYLAAE   V 
Sbjct: 1774 DNL-SREKTSDIYIKGWLYGLEKDMQKTDIHYHSLTGEADFNWRFIFTMDYLAAERTCVQ 1832

Query: 1809 SKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEM 1868
            S+K+ ++S D T  K PARL +Q+WD D FS DDFLG +ELDL+  P  A+ AKQC++ M
Sbjct: 1833 SQKDYIWSLDATSMKFPARLIIQVWDNDIFSPDDFLGVLELDLSDMPLPARHAKQCSIRM 1892

Query: 1869 ATGEVDVPL------VSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKN 1922
               +   P        S+FK+K V GWWP     +  ++ L+GKV+  L +L+ +EA   
Sbjct: 1893 MDADPKWPYFIQYKHFSLFKKKTVTGWWPCQVL-DGGKWRLSGKVKMSLEILSEKEALIK 1951

Query: 1923 PVGLARNEPD---PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLL 1979
            P G  ++EP+    L  P R +TSF W  +P+++  Y  W  YR+ L+  +++ ++ L+L
Sbjct: 1952 PAGRGQSEPNQYPTLHPPLRTNTSFTWLRSPVQNFCYIFWKRYRFKLIAFMVISIIALML 2011

Query: 1980 ALFLYSVPGYL 1990
              F+YS P YL
Sbjct: 2012 FNFIYSAPHYL 2022



 Score =  214 bits (545), Expect = 7e-55
 Identities = 184/693 (26%), Positives = 314/693 (45%), Gaps = 116/693 (16%)

Query: 248 AGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHV 307
           + +P  +QV + V EARQL+G N+ PVV V +   +  T +K   N P++NE F  +FH 
Sbjct: 161 SSKPQHFQVRVKVFEARQLMGNNIKPVVKVSIAGQQHQTRIKMGNN-PFFNEIFFQNFHE 219

Query: 308 SPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISS 367
            P   FD+ I I                    D+G +Y  P H    KW  L  P++  S
Sbjct: 220 VPAKFFDETILIQT------------------DIGFIYHSPGHTLLRKWLGLCQPNNPGS 261

Query: 368 GLKGYVKCDVAVVGKGDNIKTPHK-ANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRA 426
           G+ GY+K  +  +G GD      K    TD+ DI+   +    V P    A   + IY A
Sbjct: 262 GVTGYLKVTIYALGVGDQALIDQKLLYGTDDTDIQ---IFKSAVVPINM-AYLQLFIYCA 317

Query: 427 EGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTD 486
           E L         ++KK         V+P ++V   G+K +T +Q  +  P+WN+ + F  
Sbjct: 318 EDL---------HLKK------HQSVNPQLEVELIGEKLRTHMQTQTDNPIWNQILTFRI 362

Query: 487 LFPPLCKRMKVQIRDSDKVN-DVAIGTHFIDLRKISNDGDK------------------G 527
             P L   +K ++ D  K +    IGT  + L +IS+ G++                  G
Sbjct: 363 QLPCLSSYIKFRVLDCRKKDCPDEIGTASLSLNQISSTGEEIEGKQSLEPTSYTPRVYSG 422

Query: 528 FLPTLGPAWVNMYGSTR-NYTLLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSNPELT 586
           FLP  GP+++ ++G  +  + + +E   + + + +G+++R R+ L L  +I    +    
Sbjct: 423 FLPCFGPSFLTLHGGKKAPFRIQEEGACIPDSVRDGLAYRGRVFLELITQIKSYQD---- 478

Query: 587 SSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDG 646
           S+ +    + T I +      +++ L   FL  +M+   N  + I FEV+IG+YGN++D 
Sbjct: 479 STIKDLSHEVTRIEKH--QNRQKYGLCVIFLSCTMMP--NFKELIHFEVSIGHYGNKMDL 534

Query: 647 LSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFH-LPY 705
             +P                                  VSST P  P + D N +H +P+
Sbjct: 535 NYKP---------------------------------LVSST-PYSPVIYDGNIYHYVPW 560

Query: 706 LERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLRGVLE 765
              KP + + S W D   R+   N++    D+L+  L+ ++     +      +   +L 
Sbjct: 561 YNTKPVVAVTSNWEDVSFRMNCLNLLHFTRDRLKANLDTLKSTRNPKDPALLYQWEKLLR 620

Query: 766 ELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKL 825
           EL+  C R L            T LDR+R +     L+ + Q+A+  +        +D +
Sbjct: 621 ELAEDCKRPLPCMTY---QPKATSLDRKRWQLRSLLLQELAQKAKQAKP-------KDMV 670

Query: 826 RLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEE-ETGKDCA 884
              +++L +L  +  EPQ  +PD+ IW+++  +RVAYA+VP+  +LFS      +G+ C 
Sbjct: 671 ATAEDWLYRLNTVLPEPQMGLPDVMIWLVAKEQRVAYAQVPAHSVLFSPAGALHSGRLCG 730

Query: 885 KVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLG 917
           K++TLFL+ P   G       + A + + +WLG
Sbjct: 731 KIQTLFLQYPEGEGQKD---VLPAHLRVCMWLG 760



 Score =  143 bits (361), Expect = 1e-33
 Identities = 100/339 (29%), Positives = 170/339 (50%), Gaps = 21/339 (6%)

Query: 900  GSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQA 959
            G   W VQA ++L    G  +  K +  GL   F++ +  Q       P +   + K   
Sbjct: 1046 GRLSW-VQA-MDLKYHAGKEEDSKTWPWGLDRQFRDPQR-QDTRPPNLPFIYCTFNKPHY 1102

Query: 960  FQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELY 1019
            +QL  ++YQAR+L +        PF RV F+N SQCT+ L  +  PTW Q L+F +L LY
Sbjct: 1103 YQLFCYIYQARNLVSNQILTFQGPFIRVVFLNHSQCTQTLRSSAGPTWAQTLIFQHLLLY 1162

Query: 1020 GEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLV--KMADEAYCPPRFPPQLEYYQ 1077
                + ++ PP++V+E++ +D  GK    GR+   P+V   + D    P R+ P ++   
Sbjct: 1163 ENPQDTKESPPLVVLELWQRDFWGKESLWGRSVWPPMVWLDLQDRILPPMRWHPLVKEL- 1221

Query: 1078 IYRGNATAGDLLAAFEL-LQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVE 1136
                    G++LA+ EL LQ    G+  LP ++ P    +     +P  I+P + +  +E
Sbjct: 1222 ----GKEEGEILASCELILQTEKLGEKQLPILSVPW---KNGAYTLPKSIQPTIKRMAIE 1274

Query: 1137 VLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNF--NTLVKWFEVDLPE 1194
            +L WGLR++K+ +      P++ +E   + +++  I +++ NPNF  +  V    V +P 
Sbjct: 1275 ILAWGLRNMKKAS-----SPQLLVEFGEESLRTEPIRDFQTNPNFPESESVLVLTVLMPT 1329

Query: 1195 NELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRP 1233
             E    PL ++VVD  AFG+ T+ G   +  L+ +   P
Sbjct: 1330 EEAYALPLVVKVVDNWAFGQQTVTGQANIDFLQPYFCDP 1368


>gi|4759026 RAS protein activator like 1 [Homo sapiens]
          Length = 804

 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 37/94 (39%), Positives = 51/94 (54%), Gaps = 9/94 (9%)

Query: 962  LRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGE 1021
            LR H+  AR L   D SG SDPFARVF+ +QS  T  + +T  P WD++L         E
Sbjct: 135  LRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVL---------E 185

Query: 1022 AHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKP 1055
              E+   P  + +E++D D +GK DF+G     P
Sbjct: 186  LREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSP 219



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 25/81 (30%), Positives = 44/81 (54%), Gaps = 2/81 (2%)

Query: 1494 VRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPM 1553
            +R +V+ A DL P DI+G +DP+  +  G   +  + + I K   P + +  ++      
Sbjct: 135  LRCHVLHARDLAPRDISGTSDPFARVFWGSQSL--ETSTIKKTRFPHWDEVLELREMPGA 192

Query: 1554 ESMLTVAVYDWDLVGTDDLIG 1574
             S L V ++DWD+VG +D +G
Sbjct: 193  PSPLRVELWDWDMVGKNDFLG 213



 Score = 39.7 bits (91), Expect = 0.030
 Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 2/88 (2%)

Query: 1494 VRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPM 1553
            + V VV    L   D++G +DPY  +++   ++  +   + + L P +G+ + +      
Sbjct: 7    LNVRVVEGRALPAKDVSGSSDPYCLVKVDD-EVVARTATVWRSLGPFWGEEYTVHLPLDF 65

Query: 1554 ESMLTVAVYDWDLVGTDDLIGETKIDLE 1581
               L   V D D VG DD+IG+  +  E
Sbjct: 66   HQ-LAFYVLDEDTVGHDDIIGKISLSRE 92


>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
            isoform 2 [Homo sapiens]
          Length = 731

 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 1494 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 1552
            +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 63   LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 119

Query: 1553 MESMLTVAVYDWDLVGTDDLIGETKIDLE 1581
                L V  +DWDLV  +D +G+  ID++
Sbjct: 120  AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 148



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 953  VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 1012
            V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 54   VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 113

Query: 1013 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 1050
            F+  E   EA         + +E +D D + + DF+G+
Sbjct: 114  FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 142



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 24/70 (34%), Positives = 39/70 (55%), Gaps = 4/70 (5%)

Query: 453 DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKV--NDVAI 510
           DP+V+V + G+  +TS+ K S  P WNE   F +L     + + V+  D D V  ND  +
Sbjct: 83  DPFVRVRYKGRTRETSIVKKSCYPRWNETFEF-ELQEGAMEALCVEAWDWDLVSRNDF-L 140

Query: 511 GTHFIDLRKI 520
           G   ID++++
Sbjct: 141 GKVVIDVQRL 150



 Score = 31.6 bits (70), Expect = 8.1
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1799 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1853
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 90   YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 149


>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
            isoform 1 [Homo sapiens]
          Length = 757

 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 1494 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 1552
            +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 135  LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 191

Query: 1553 MESMLTVAVYDWDLVGTDDLIGETKIDLE 1581
                L V  +DWDLV  +D +G+  ID++
Sbjct: 192  AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 220



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 953  VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 1012
            V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 126  VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185

Query: 1013 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 1050
            F+  E   EA         + +E +D D + + DF+G+
Sbjct: 186  FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 214



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 24/70 (34%), Positives = 39/70 (55%), Gaps = 4/70 (5%)

Query: 453 DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKV--NDVAI 510
           DP+V+V + G+  +TS+ K S  P WNE   F +L     + + V+  D D V  ND  +
Sbjct: 155 DPFVRVRYKGRTRETSIVKKSCYPRWNETFEF-ELQEGAMEALCVEAWDWDLVSRNDF-L 212

Query: 511 GTHFIDLRKI 520
           G   ID++++
Sbjct: 213 GKVVIDVQRL 222



 Score = 31.6 bits (70), Expect = 8.1
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1799 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1853
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 162  YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 221


>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
            isoform 1 [Homo sapiens]
          Length = 731

 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 1494 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 1552
            +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 63   LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 119

Query: 1553 MESMLTVAVYDWDLVGTDDLIGETKIDLE 1581
                L V  +DWDLV  +D +G+  ID++
Sbjct: 120  AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 148



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 953  VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 1012
            V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 54   VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 113

Query: 1013 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 1050
            F+  E   EA         + +E +D D + + DF+G+
Sbjct: 114  FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 142



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 24/70 (34%), Positives = 39/70 (55%), Gaps = 4/70 (5%)

Query: 453 DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKV--NDVAI 510
           DP+V+V + G+  +TS+ K S  P WNE   F +L     + + V+  D D V  ND  +
Sbjct: 83  DPFVRVRYKGRTRETSIVKKSCYPRWNETFEF-ELQEGAMEALCVEAWDWDLVSRNDF-L 140

Query: 511 GTHFIDLRKI 520
           G   ID++++
Sbjct: 141 GKVVIDVQRL 150



 Score = 31.6 bits (70), Expect = 8.1
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1799 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1853
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 90   YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 149


>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
            isoform 2 [Homo sapiens]
          Length = 757

 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 1494 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 1552
            +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 135  LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 191

Query: 1553 MESMLTVAVYDWDLVGTDDLIGETKIDLE 1581
                L V  +DWDLV  +D +G+  ID++
Sbjct: 192  AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 220



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 953  VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 1012
            V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 126  VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185

Query: 1013 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 1050
            F+  E   EA         + +E +D D + + DF+G+
Sbjct: 186  FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 214



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 24/70 (34%), Positives = 39/70 (55%), Gaps = 4/70 (5%)

Query: 453 DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKV--NDVAI 510
           DP+V+V + G+  +TS+ K S  P WNE   F +L     + + V+  D D V  ND  +
Sbjct: 155 DPFVRVRYKGRTRETSIVKKSCYPRWNETFEF-ELQEGAMEALCVEAWDWDLVSRNDF-L 212

Query: 511 GTHFIDLRKI 520
           G   ID++++
Sbjct: 213 GKVVIDVQRL 222



 Score = 31.6 bits (70), Expect = 8.1
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1799 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1853
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 162  YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 221


>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
          Length = 757

 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 1494 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 1552
            +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 135  LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 191

Query: 1553 MESMLTVAVYDWDLVGTDDLIGETKIDLE 1581
                L V  +DWDLV  +D +G+  ID++
Sbjct: 192  AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 220



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 953  VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 1012
            V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 126  VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185

Query: 1013 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 1050
            F+  E   EA         + +E +D D + + DF+G+
Sbjct: 186  FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 214



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 24/70 (34%), Positives = 39/70 (55%), Gaps = 4/70 (5%)

Query: 453 DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKV--NDVAI 510
           DP+V+V + G+  +TS+ K S  P WNE   F +L     + + V+  D D V  ND  +
Sbjct: 155 DPFVRVRYKGRTRETSIVKKSCYPRWNETFEF-ELQEGAMEALCVEAWDWDLVSRNDF-L 212

Query: 511 GTHFIDLRKI 520
           G   ID++++
Sbjct: 213 GKVVIDVQRL 222



 Score = 31.6 bits (70), Expect = 8.1
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1799 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1853
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 162  YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 221


>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
          Length = 803

 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 29/89 (32%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 1494 VRVYVVRATDLHPADINGKADPYIAIRL-GKTDIRDKENYISKQLNPVFGKSFDIEASFP 1552
            +R  V+ A DL P D NG +DP++ +R  G+T    + + + K   P + ++F+ E    
Sbjct: 135  LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFELQEG 191

Query: 1553 MESMLTVAVYDWDLVGTDDLIGETKIDLE 1581
                L V  +DWDLV  +D +G+  ID++
Sbjct: 192  AMEALCVEAWDWDLVSRNDFLGKVVIDVQ 220



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 28/98 (28%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 953  VYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLV 1012
            V+   +A +LR  + +AR L   D +G SDPF RV +  +++ T ++ ++  P W++   
Sbjct: 126  VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185

Query: 1013 FDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR 1050
            F+  E   EA         + +E +D D + + DF+G+
Sbjct: 186  FELQEGAMEA---------LCVEAWDWDLVSRNDFLGK 214



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 24/70 (34%), Positives = 39/70 (55%), Gaps = 4/70 (5%)

Query: 453 DPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKV--NDVAI 510
           DP+V+V + G+  +TS+ K S  P WNE   F +L     + + V+  D D V  ND  +
Sbjct: 155 DPFVRVRYKGRTRETSIVKKSCYPRWNETFEF-ELQEGAMEALCVEAWDWDLVSRNDF-L 212

Query: 511 GTHFIDLRKI 520
           G   ID++++
Sbjct: 213 GKVVIDVQRL 222



 Score = 31.6 bits (70), Expect = 8.1
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 1799 YLAAEEKIVISKKESMFSWDET-EYKIPA----RLTLQIWDADHFSADDFLGAIELDLNR 1853
            Y     +  I KK     W+ET E+++       L ++ WD D  S +DFLG + +D+ R
Sbjct: 162  YKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQR 221


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,968,793
Number of Sequences: 37866
Number of extensions: 4088810
Number of successful extensions: 21328
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 404
Number of HSP's that attempted gapping in prelim test: 16520
Number of HSP's gapped (non-prelim): 3206
length of query: 1997
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1880
effective length of database: 13,817,196
effective search space: 25976328480
effective search space used: 25976328480
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.