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Search of human proteins with 34222199
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34222199 leucine rich repeat containing 8 family, member D
[Homo sapiens]
(858 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197333706 leucine rich repeat containing 8 family, member D [... 1725 0.0
gi|34222199 leucine rich repeat containing 8 family, member D [H... 1725 0.0
gi|62241040 leucine rich repeat containing 8 family, member A [H... 926 0.0
gi|187829877 leucine rich repeat containing 8 family, member A [... 926 0.0
gi|187829871 leucine rich repeat containing 8 family, member A [... 926 0.0
gi|19923729 leucine rich repeat containing 8 family, member C [H... 858 0.0
gi|40217803 leucine rich repeat containing 8 family, member E [H... 806 0.0
gi|197333692 leucine rich repeat containing 8 family, member B [... 769 0.0
gi|21245134 leucine rich repeat containing 8 family, member B [H... 769 0.0
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 120 4e-27
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 119 9e-27
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 117 6e-26
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 110 4e-24
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 110 4e-24
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 110 7e-24
gi|45827729 scribble isoform b [Homo sapiens] 110 7e-24
gi|45827731 scribble isoform a [Homo sapiens] 110 7e-24
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 109 9e-24
gi|4503743 flightless I homolog [Homo sapiens] 105 1e-22
gi|238908508 leucine-rich repeat and death domain-containing pro... 105 2e-22
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 103 5e-22
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 103 5e-22
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 95 2e-19
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 92 2e-18
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 91 5e-18
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 91 6e-18
gi|61742786 leucine rich repeat and death domain containing prot... 90 8e-18
gi|61742784 leucine rich repeat and death domain containing prot... 90 8e-18
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 88 4e-17
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 88 4e-17
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 1725 bits (4468), Expect = 0.0
Identities = 858/858 (100%), Positives = 858/858 (100%)
Query: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS
Sbjct: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
Query: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF
Sbjct: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS
Sbjct: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST
Sbjct: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED
Sbjct: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY
Sbjct: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL
Sbjct: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS
Sbjct: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR
Sbjct: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT
Sbjct: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL
Sbjct: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES
Sbjct: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL
Sbjct: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL
Sbjct: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
Query: 841 EVKEALNQDINIPFANGI 858
EVKEALNQDINIPFANGI
Sbjct: 841 EVKEALNQDINIPFANGI 858
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 1725 bits (4468), Expect = 0.0
Identities = 858/858 (100%), Positives = 858/858 (100%)
Query: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS
Sbjct: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
Query: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF
Sbjct: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS
Sbjct: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST
Sbjct: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED
Sbjct: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY
Sbjct: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL
Sbjct: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS
Sbjct: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR
Sbjct: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT
Sbjct: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL
Sbjct: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES
Sbjct: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL
Sbjct: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL
Sbjct: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
Query: 841 EVKEALNQDINIPFANGI 858
EVKEALNQDINIPFANGI
Sbjct: 841 EVKEALNQDINIPFANGI 858
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 926 bits (2392), Expect = 0.0
Identities = 460/846 (54%), Positives = 612/846 (72%), Gaps = 44/846 (5%)
Query: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
M + E+ D QP YRILKPWWDVF DY+++VMLM+A+F GT+Q+T+D+++CLP
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPC--- 57
Query: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
VT + + ND G +A P+ TYP +
Sbjct: 58 ------------KWVTKD---------------SCNDSFRGWAAPGPE----PTYPNSTI 86
Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
LP + PTG K +LD QY +++ +CY L W++KYFPYL L+HT+I + S
Sbjct: 87 -LPTPDT-----GPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACS 140
Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
NFWFK+P+T SK+EHFVSIL KCF+SPWTT+ALSET E+S+ ++ K ST
Sbjct: 141 NFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDKKSST 200
Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
S++ A+ PM+ +T K E+ +++ +LDKK+GEQAKALFEKV+KFR HVE+
Sbjct: 201 VSED--VEATVPMLQRT--KSRIEQGIVDRSETGVLDKKEGEQAKALFEKVKKFRTHVEE 256
Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
D++Y+LY+ QT+IK KFI I+CYT +V+ I F+ C +E L GY + C H +A
Sbjct: 257 GDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHPLAT 316
Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
+ K L YIS++ YG IC+YTL+W+ R LK+YSFE +REESS+SDIPDVKNDFAF+L
Sbjct: 317 LFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFML 376
Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
H++DQYD LYSKRF VFLSEVSENKLR+++LN+EWT +KLRQ +++NAQDK ELHLFMLS
Sbjct: 377 HLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLS 436
Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
G+PD VFDL +L+VLKLELIP+ IP I+Q+T L+EL L H AK+E A +FLR++LR
Sbjct: 437 GIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLR 496
Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
LH+KFTD+ EIP W+Y LK L EL+L GNL++ENN+ I ++ LREL+ LK+L +KSNL+
Sbjct: 497 ALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLS 556
Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
K+P +TDV HL KL I+N+GTKL+VLNSLKKM N+ ELEL C+LERIPH+IFSL NL
Sbjct: 557 KLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNL 616
Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
QE+DLK NN++TIEEIISFQHL RLTCLKLW+N I IP I ++ NLE LY + NK+E
Sbjct: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
+P +F +KLR LD+S+NN++ +P +IGLLQNLQ+L IT N+++ LP +LF+C KLR L
Sbjct: 677 IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736
Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
+LG N + SLP +VG+L+ LTQ+EL+GN L+ LP +LG+C +LK+SGLVVE+ LF+TLP
Sbjct: 737 HLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPP 796
Query: 841 EVKEAL 846
EVKE L
Sbjct: 797 EVKERL 802
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 926 bits (2392), Expect = 0.0
Identities = 460/846 (54%), Positives = 612/846 (72%), Gaps = 44/846 (5%)
Query: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
M + E+ D QP YRILKPWWDVF DY+++VMLM+A+F GT+Q+T+D+++CLP
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPC--- 57
Query: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
VT + + ND G +A P+ TYP +
Sbjct: 58 ------------KWVTKD---------------SCNDSFRGWAAPGPE----PTYPNSTI 86
Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
LP + PTG K +LD QY +++ +CY L W++KYFPYL L+HT+I + S
Sbjct: 87 -LPTPDT-----GPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACS 140
Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
NFWFK+P+T SK+EHFVSIL KCF+SPWTT+ALSET E+S+ ++ K ST
Sbjct: 141 NFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDKKSST 200
Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
S++ A+ PM+ +T K E+ +++ +LDKK+GEQAKALFEKV+KFR HVE+
Sbjct: 201 VSED--VEATVPMLQRT--KSRIEQGIVDRSETGVLDKKEGEQAKALFEKVKKFRTHVEE 256
Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
D++Y+LY+ QT+IK KFI I+CYT +V+ I F+ C +E L GY + C H +A
Sbjct: 257 GDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHPLAT 316
Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
+ K L YIS++ YG IC+YTL+W+ R LK+YSFE +REESS+SDIPDVKNDFAF+L
Sbjct: 317 LFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFML 376
Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
H++DQYD LYSKRF VFLSEVSENKLR+++LN+EWT +KLRQ +++NAQDK ELHLFMLS
Sbjct: 377 HLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLS 436
Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
G+PD VFDL +L+VLKLELIP+ IP I+Q+T L+EL L H AK+E A +FLR++LR
Sbjct: 437 GIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLR 496
Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
LH+KFTD+ EIP W+Y LK L EL+L GNL++ENN+ I ++ LREL+ LK+L +KSNL+
Sbjct: 497 ALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLS 556
Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
K+P +TDV HL KL I+N+GTKL+VLNSLKKM N+ ELEL C+LERIPH+IFSL NL
Sbjct: 557 KLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNL 616
Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
QE+DLK NN++TIEEIISFQHL RLTCLKLW+N I IP I ++ NLE LY + NK+E
Sbjct: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
+P +F +KLR LD+S+NN++ +P +IGLLQNLQ+L IT N+++ LP +LF+C KLR L
Sbjct: 677 IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736
Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
+LG N + SLP +VG+L+ LTQ+EL+GN L+ LP +LG+C +LK+SGLVVE+ LF+TLP
Sbjct: 737 HLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPP 796
Query: 841 EVKEAL 846
EVKE L
Sbjct: 797 EVKERL 802
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 926 bits (2392), Expect = 0.0
Identities = 460/846 (54%), Positives = 612/846 (72%), Gaps = 44/846 (5%)
Query: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
M + E+ D QP YRILKPWWDVF DY+++VMLM+A+F GT+Q+T+D+++CLP
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPC--- 57
Query: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
VT + + ND G +A P+ TYP +
Sbjct: 58 ------------KWVTKD---------------SCNDSFRGWAAPGPE----PTYPNSTI 86
Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
LP + PTG K +LD QY +++ +CY L W++KYFPYL L+HT+I + S
Sbjct: 87 -LPTPDT-----GPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACS 140
Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
NFWFK+P+T SK+EHFVSIL KCF+SPWTT+ALSET E+S+ ++ K ST
Sbjct: 141 NFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDKKSST 200
Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
S++ A+ PM+ +T K E+ +++ +LDKK+GEQAKALFEKV+KFR HVE+
Sbjct: 201 VSED--VEATVPMLQRT--KSRIEQGIVDRSETGVLDKKEGEQAKALFEKVKKFRTHVEE 256
Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
D++Y+LY+ QT+IK KFI I+CYT +V+ I F+ C +E L GY + C H +A
Sbjct: 257 GDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHPLAT 316
Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
+ K L YIS++ YG IC+YTL+W+ R LK+YSFE +REESS+SDIPDVKNDFAF+L
Sbjct: 317 LFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFML 376
Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
H++DQYD LYSKRF VFLSEVSENKLR+++LN+EWT +KLRQ +++NAQDK ELHLFMLS
Sbjct: 377 HLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLS 436
Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
G+PD VFDL +L+VLKLELIP+ IP I+Q+T L+EL L H AK+E A +FLR++LR
Sbjct: 437 GIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLR 496
Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
LH+KFTD+ EIP W+Y LK L EL+L GNL++ENN+ I ++ LREL+ LK+L +KSNL+
Sbjct: 497 ALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLS 556
Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
K+P +TDV HL KL I+N+GTKL+VLNSLKKM N+ ELEL C+LERIPH+IFSL NL
Sbjct: 557 KLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNL 616
Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
QE+DLK NN++TIEEIISFQHL RLTCLKLW+N I IP I ++ NLE LY + NK+E
Sbjct: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
+P +F +KLR LD+S+NN++ +P +IGLLQNLQ+L IT N+++ LP +LF+C KLR L
Sbjct: 677 IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736
Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
+LG N + SLP +VG+L+ LTQ+EL+GN L+ LP +LG+C +LK+SGLVVE+ LF+TLP
Sbjct: 737 HLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPP 796
Query: 841 EVKEAL 846
EVKE L
Sbjct: 797 EVKERL 802
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 858 bits (2216), Expect = 0.0
Identities = 428/849 (50%), Positives = 582/849 (68%), Gaps = 46/849 (5%)
Query: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
M + E ++ QP +R+LKPWWDVF DYL+V MLM+ +F T+Q+ +D+++CLP
Sbjct: 1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQ 60
Query: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
P Q+ + +++S ++ TP P P+
Sbjct: 61 PA---------------------------QNHSSLSNVSQAVASTTPLPP-----PKPSP 88
Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
A P K G KT+LD QQY FINQMCY AL WY+KYFPYL LIHT++ M+ S
Sbjct: 89 ANPITVEMK------GLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCS 142
Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
NFWFK+P + SK+EHF+SILGKCF+SPWTT+ALSE + EDSEE R +
Sbjct: 143 NFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMNR--SNTIQ 200
Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
S EGS ++N K EK V++ + LDKK+GEQAKALFEKV+KFR HVE+
Sbjct: 201 SGPEGS------LVNSQSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEE 254
Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
D++Y +YV QTV+K KF+ I+ Y + V+ + F C ++ + GY+ F C H MA+
Sbjct: 255 GDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAH 314
Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
+ KL Y+ + +YG CLYTL+WLF L+EYSFE VR+E+ DIPDVKNDFAF+L
Sbjct: 315 LFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGIDDIPDVKNDFAFML 374
Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
HM+DQYD LYSKRF VFLSEVSENKL++++LN+EWT +KLRQ + NA ++ EL L MLS
Sbjct: 375 HMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLS 434
Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
G+PD VF++T+L LKLE+I IPA I+Q+ NLQEL L C K+ A SFL+++L+
Sbjct: 435 GLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLK 494
Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
L VKF D+ E+P W+Y L+NL ELYL+G+L+ + ++ + LESLR+L+ LKIL +KSN++
Sbjct: 495 VLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVS 554
Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
K+P + DV+ HL K+ IHNDGTKL++LN+LKKM N+ ELEL +C+LERIPHA+FSL +L
Sbjct: 555 KIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSL 614
Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
QELDLK NN+++IEEI+SFQHL++LT LKLWHN I IP I + +LE L FS+NK+E
Sbjct: 615 QELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEV 674
Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
LP +F K+R LD+SYN+I IP EIG+LQ+LQ+ IT NKV+ LP +L+ C KL+TL
Sbjct: 675 LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTL 734
Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
+G+N ++ L K+G L L+ L++KGN + LP +LG CR LK++GLVVED LF+TLP
Sbjct: 735 KIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPS 794
Query: 841 EVKEALNQD 849
+V+E + +
Sbjct: 795 DVREQMKTE 803
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 806 bits (2082), Expect = 0.0
Identities = 411/850 (48%), Positives = 559/850 (65%), Gaps = 55/850 (6%)
Query: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
M +AE + QP +++LKPWWDV +YL V MLM+ +F T+Q+T+D+++CLP
Sbjct: 1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLP---- 56
Query: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
N E+ N+ + P + PR
Sbjct: 57 -----------NHELQENLS---------------------------EAPCQQLLPR--- 75
Query: 121 ALPNQ-EAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVS 179
+P Q A +E K G K NLD QQY FINQ+CY AL WY+KYFPYL +IHT+I MV
Sbjct: 76 GIPEQIGALQEVK---GLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVC 132
Query: 180 SNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVS 239
++FWFK+P T SK+EHF+SILGKCF+SPWTT+ALSE + E+ + A T+
Sbjct: 133 TSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENQKGPAATERAAATIVAMAG 192
Query: 240 TSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVE 299
T + ++ + EK V E P +T+LDKK+GEQAKALFEKV+KFR HVE
Sbjct: 193 TGPGKAGEGEKEKVLAEP------EKVVTEPPVVTLLDKKEGEQAKALFEKVKKFRMHVE 246
Query: 300 DSDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMA 359
+ D++Y +Y+ QTV+K KF+ IL Y +V ISF C+ + + GY F C H A
Sbjct: 247 EGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVETSEVTGYASFCCNHTKA 306
Query: 360 YMLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFL 419
++ KL YIS +C+YG C+YTL+WLF PLKEYSF VREE+ DIPDVKNDFAF+
Sbjct: 307 HLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREETGMGDIPDVKNDFAFM 366
Query: 420 LHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFML 479
LH++DQYD LYSKRF VFLSEVSE++L++++LNHEWT EKLRQ + RNA + EL L ML
Sbjct: 367 LHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNAAGRLELALCML 426
Query: 480 SGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHL 539
G+PD VF+L++++ L+LE I + P +SQ+ +LQEL L H PA++ + FLRDHL
Sbjct: 427 PGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHL 486
Query: 540 RCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNL 599
+ + VK ++ E+P WV+ L+ L EL+L G E + LESLREL+ LK+L ++SN
Sbjct: 487 KVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNA 546
Query: 600 TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSN 659
KVP+++TDVA HL +L +HNDG +L+ LNSLKK+ + ELEL C LERIPHA+FSL
Sbjct: 547 GKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGA 606
Query: 660 LQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE 719
LQELDLK N++R+IEEI+SFQH ++L L+LWHN+I +P + +++LE LY S NKLE
Sbjct: 607 LQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLE 666
Query: 720 SLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRT 779
+LP + LR LDVS+N + +P E+GLLQNLQHL ++ N ++ LP++LF C KLRT
Sbjct: 667 TLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRT 726
Query: 780 LNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
L LG N ++ L VG L L++LELKGN L+ LP +LG C LKK+GL+VED L+ LP
Sbjct: 727 LLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLP 786
Query: 840 LEVKEALNQD 849
EV++ + ++
Sbjct: 787 AEVRDKMEEE 796
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 769 bits (1986), Expect = 0.0
Identities = 393/846 (46%), Positives = 561/846 (66%), Gaps = 50/846 (5%)
Query: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
M TL E+ L D Q +Y ILKPWWDVF Y+ ++ML+VA+ AG +QLT+ +V+C LP
Sbjct: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCC--LPC 58
Query: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
V H V +I K T+ + P T
Sbjct: 59 KVEFDNH-----CAVPWDILKASMNTSSN--------------------------PGTPL 87
Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
LP + + +L QQY +I+ +CY L W++K+FPYL L+HT+I S
Sbjct: 88 PLPLRI-----------QNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACS 136
Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
NFW YP T S++EHFV+IL KCF+SPWTT+ALSET E S +++ ++ L
Sbjct: 137 NFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVR-PLKLSKSKILLSSSGC 195
Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
S+D S S P E IE P+ ++LDKK+GEQAKA+FEKV++FR HVE
Sbjct: 196 SADIDSGKQSLPYPQP-----GLESAGIESPTSSVLDKKEGEQAKAIFEKVKRFRMHVEQ 250
Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
D+IY++Y+ Q ++K F+ I+ Y F+ I+ E C V+ GY+ ++C +++A
Sbjct: 251 KDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLAE 310
Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
+ K L Y+ ++ +YG Y+L+W+ R LK+YSFE +RE+S++SDIPDVKNDFAF+L
Sbjct: 311 IFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFIL 370
Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
H+ DQYD LYSKRF +FLSEVSENKL++I+LN+EWT EKL+ + +NAQDK ELHLFML+
Sbjct: 371 HLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLN 430
Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
G+PD VF+LT+++VL LELIPE K+P+ +SQ+ NL+EL + H V+ A +FL ++L+
Sbjct: 431 GLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLK 490
Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
L +KFT++ +IP WV+ LKNL+ELYL G + E + LE ++L++L+ L++KS+L+
Sbjct: 491 ILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLS 550
Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
++P +TD+ P L KL + N+G+KL+VLN+LKKM+N+ LEL +C+LERIPH+IFSL+NL
Sbjct: 551 RIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNL 610
Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
ELDL+ NN++T+EEIISFQHL+ L+CLKLWHN I IP I + NLE L +N +E+
Sbjct: 611 HELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670
Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
LP+ +F KL LD+SYN+++ IP EI L NLQ+ +T N +++LP LF+C KL+ L
Sbjct: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCL 730
Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
LG+N + +L VG+LS LT LEL GN L+ LP +L C+ LK++ L+VE++L +TLPL
Sbjct: 731 LLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPL 790
Query: 841 EVKEAL 846
V E L
Sbjct: 791 PVTERL 796
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 769 bits (1986), Expect = 0.0
Identities = 393/846 (46%), Positives = 561/846 (66%), Gaps = 50/846 (5%)
Query: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
M TL E+ L D Q +Y ILKPWWDVF Y+ ++ML+VA+ AG +QLT+ +V+C LP
Sbjct: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCC--LPC 58
Query: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
V H V +I K T+ + P T
Sbjct: 59 KVEFDNH-----CAVPWDILKASMNTSSN--------------------------PGTPL 87
Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
LP + + +L QQY +I+ +CY L W++K+FPYL L+HT+I S
Sbjct: 88 PLPLRI-----------QNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACS 136
Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
NFW YP T S++EHFV+IL KCF+SPWTT+ALSET E S +++ ++ L
Sbjct: 137 NFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVR-PLKLSKSKILLSSSGC 195
Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
S+D S S P E IE P+ ++LDKK+GEQAKA+FEKV++FR HVE
Sbjct: 196 SADIDSGKQSLPYPQP-----GLESAGIESPTSSVLDKKEGEQAKAIFEKVKRFRMHVEQ 250
Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
D+IY++Y+ Q ++K F+ I+ Y F+ I+ E C V+ GY+ ++C +++A
Sbjct: 251 KDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLAE 310
Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
+ K L Y+ ++ +YG Y+L+W+ R LK+YSFE +RE+S++SDIPDVKNDFAF+L
Sbjct: 311 IFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFIL 370
Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
H+ DQYD LYSKRF +FLSEVSENKL++I+LN+EWT EKL+ + +NAQDK ELHLFML+
Sbjct: 371 HLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLN 430
Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
G+PD VF+LT+++VL LELIPE K+P+ +SQ+ NL+EL + H V+ A +FL ++L+
Sbjct: 431 GLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLK 490
Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
L +KFT++ +IP WV+ LKNL+ELYL G + E + LE ++L++L+ L++KS+L+
Sbjct: 491 ILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLS 550
Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
++P +TD+ P L KL + N+G+KL+VLN+LKKM+N+ LEL +C+LERIPH+IFSL+NL
Sbjct: 551 RIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNL 610
Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
ELDL+ NN++T+EEIISFQHL+ L+CLKLWHN I IP I + NLE L +N +E+
Sbjct: 611 HELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670
Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
LP+ +F KL LD+SYN+++ IP EI L NLQ+ +T N +++LP LF+C KL+ L
Sbjct: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCL 730
Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
LG+N + +L VG+LS LT LEL GN L+ LP +L C+ LK++ L+VE++L +TLPL
Sbjct: 731 LLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPL 790
Query: 841 EVKEAL 846
V E L
Sbjct: 791 PVTERL 796
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 120 bits (302), Expect = 4e-27
Identities = 99/345 (28%), Positives = 176/345 (51%), Gaps = 14/345 (4%)
Query: 482 VPDAVFDLT-DLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPA-KVEQTAFSFLRDHL 539
VP+ ++ L+ L L+ ++P + Q+ L++L L ++ +F++ L
Sbjct: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQ--L 84
Query: 540 RCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKS-N 598
L V ++ EIP + K L+ GN + ES EL++L L V +
Sbjct: 85 VELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLP-----ESFPELQNLTCLSVNDIS 139
Query: 599 LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658
L +P NI ++ +L L + + L +SL ++ + EL+L N E+ +P +I +L
Sbjct: 140 LQSLPENIGNLY-NLASLELRENLLTYLP-DSLTQLRRLEELDLGNNEIYNLPESIGALL 197
Query: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
+L++L L N + + + I +LK L CL + N++ +P I+ + +L L S N L
Sbjct: 198 HLKDLWLDGNQLSELPQEIG--NLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLL 255
Query: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLR 778
E++P + L+KL L V N ++ +P +G ++L L +T N++ LPK + K KL
Sbjct: 256 ETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLS 315
Query: 779 TLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRML 823
LN +N + SLP+++G LT ++ N L R+PA++ Q L
Sbjct: 316 NLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATEL 360
Score = 115 bits (287), Expect = 2e-25
Identities = 97/323 (30%), Positives = 157/323 (48%), Gaps = 14/323 (4%)
Query: 522 HCP-AKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIG 580
HC V + + + R L L + + E+P + L LR+L L S+N
Sbjct: 21 HCSLVYVPEEIYRYARS-LEELLLDANQLRELPEQFFQLVKLRKLGL-----SDNEIQRL 74
Query: 581 LESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAE 639
+ L L V N + ++P +I+ N T+L S ++ N+
Sbjct: 75 PPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLP--ESFPELQNLTC 132
Query: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
L + + L+ +P I +L NL L+L+ N + + + S L+RL L L +N+I +P
Sbjct: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPD--SLTQLRRLEELDLGNNEIYNLP 190
Query: 700 PSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHI 759
SI + +L+ L+ N+L LP + +L+ L CLDVS N + +P EI L +L L I
Sbjct: 191 ESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVI 250
Query: 760 TGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQ 819
+ N ++ +P + K KL L + QN +T LPE VG+ LT+L L N L LP +G
Sbjct: 251 SQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIG- 309
Query: 820 CRMLKKSGLVVEDHLFDTLPLEV 842
++ K S L + + +LP E+
Sbjct: 310 -KLKKLSNLNADRNKLVSLPKEI 331
Score = 107 bits (266), Expect = 6e-23
Identities = 107/363 (29%), Positives = 170/363 (46%), Gaps = 21/363 (5%)
Query: 462 QHISRNAQDKQELHLF--MLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELH 519
+ I R A+ +EL L L +P+ F L L L L ++P +I+ L EL
Sbjct: 29 EEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELD 88
Query: 520 LCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMI 579
+ + SF C ++ D + P L ++ EL NL + I
Sbjct: 89 VSRNEIPEIPESISF------CKALQVADFSGNPL-TRLPESFPELQ---NLTCLSVNDI 138
Query: 580 GLESLRE----LRHLKILHVKSNL-TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKM 634
L+SL E L +L L ++ NL T +P ++T + L +L + N+ L S+ +
Sbjct: 139 SLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLR-RLEELDLGNNEIYNLP-ESIGAL 196
Query: 635 MNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNK 694
+++ +L L +L +P I +L NL LD+ N + + E IS L LT L + N
Sbjct: 197 LHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEIS--GLTSLTDLVISQNL 254
Query: 695 IVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNL 754
+ TIP I +K L L N+L LP AV + L L ++ N + +P IG L+ L
Sbjct: 255 LETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKL 314
Query: 755 QHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814
+L+ NK+ LPK++ C L + N +T +P +V Q ++L L++ GN L LP
Sbjct: 315 SNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLP 374
Query: 815 AQL 817
L
Sbjct: 375 LSL 377
Score = 82.4 bits (202), Expect = 2e-15
Identities = 86/334 (25%), Positives = 156/334 (46%), Gaps = 24/334 (7%)
Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
L+ +P++ +L +L L + I +P I + NL L L + + LR
Sbjct: 117 LTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLR-R 175
Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
L L + ++ +P + L +L++L+L GN SE + IG L++L L V N
Sbjct: 176 LEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIG-----NLKNLLCLDVSEN 230
Query: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
L ++P I+ + LT LVI + + + + + K+ ++ L++ L ++P A+
Sbjct: 231 RLERLPEEISGLTS-LTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLPEAVGEC 288
Query: 658 SNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
+L EL L N + T+ + I LK+L+ L NK+V++P I +L +N+
Sbjct: 289 ESLTELVLTENQLLTLPKSIG--KLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNR 346
Query: 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDIL---------- 767
L +P V +L LDV+ N + +P+ + L+ L+ L ++ N+ L
Sbjct: 347 LTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK-LKALWLSDNQSQPLLTFQTDTDYT 405
Query: 768 -PKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800
+++ C+ L L C +LP + G L L
Sbjct: 406 TGEKILTCVLLPQLPSEPTCQENLP-RCGALENL 438
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 119 bits (299), Expect = 9e-27
Identities = 74/234 (31%), Positives = 131/234 (55%), Gaps = 10/234 (4%)
Query: 613 LTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRT 672
L+K IH ++ +S+K++ + EL L + +L+ +P + L NL L L N++ +
Sbjct: 107 LSKRSIH------ILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
Query: 673 IEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLR 732
+ + S +LK+L L L HNK+ IP + + +L +LY N++ ++ + +L KL
Sbjct: 161 LPD--SLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLS 218
Query: 733 CLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPE 792
L + N I +P EIG L NL L + N+++ LPK++ C ++ L+L N + LP+
Sbjct: 219 MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPD 278
Query: 793 KVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEAL 846
+G LS L++L L+ N L +P L +C L++ L +E++ TLP + +L
Sbjct: 279 TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEE--LNLENNNISTLPESLLSSL 330
Score = 119 bits (298), Expect = 1e-26
Identities = 99/365 (27%), Positives = 178/365 (48%), Gaps = 24/365 (6%)
Query: 488 DLTDLDVLKLELIPEAKI---PAKISQMTNLQELHLCH-----CPAKVEQTAFSFLRDHL 539
D+ +L L + I E KI PA+I ++ NL L + H P ++ +
Sbjct: 210 DIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCT------QI 263
Query: 540 RCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNL 599
L ++ ++ ++P + L +L L L N S + + S E +L+ +N+
Sbjct: 264 TNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLE----NNNI 319
Query: 600 TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSN 659
+ +P ++ L L + + +L + + + L +++ + +IP IFS +
Sbjct: 320 STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAK 379
Query: 660 -LQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
L +L++K N + ++ + F + L L N++ IP ++ + +LE L SNN L
Sbjct: 380 VLSKLNMKDNQLTSLP--LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLL 437
Query: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLR 778
+ LP + +L+KLR LD+ N + +P EI L++LQ L +T N++ LP+ + L
Sbjct: 438 KKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLT 497
Query: 779 TLNLGQNCITSLPEKVGQLSQLTQLELKGN-CLDRLPAQLGQCRMLKKSGLVVEDHLFDT 837
L LG+N +T LPE++G L L +L L N L LP +L C K S + +E+
Sbjct: 498 HLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCS--KLSIMSIENCPLSH 555
Query: 838 LPLEV 842
LP ++
Sbjct: 556 LPPQI 560
Score = 115 bits (289), Expect = 1e-25
Identities = 102/401 (25%), Positives = 190/401 (47%), Gaps = 38/401 (9%)
Query: 471 KQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQT 530
K+ +H+ +P ++ +LT L L L +PA++ + NL L L
Sbjct: 109 KRSIHI-----LPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163
Query: 531 AFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHL 590
+ L+ LR L ++ + EIP+ VY L +L LYL N + K ++ L L
Sbjct: 164 SLDNLKK-LRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEK-----DIKNLSKL 217
Query: 591 KILHVKSN-LTKVPSNITDVAPHLTKLVIHN--------------------DGTKLLVL- 628
+L ++ N + ++P+ I ++ +T V HN +LL L
Sbjct: 218 SMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP 277
Query: 629 NSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCL 688
+++ + +++ L L+ L IP ++ S L+EL+L++NNI T+ E + L +L L
Sbjct: 278 DTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESL-LSSLVKLNSL 336
Query: 689 KLWHNKIVTIP-PSITHVKNLESLYFSNNKLESLPVAVFSLQK-LRCLDVSYNNISMIPI 746
L N P + + SL +N++ +P +FS K L L++ N ++ +P+
Sbjct: 337 TLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPL 396
Query: 747 EIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELK 806
+ G ++ L++ N++ +P+ + + L L L N + LP +G L +L +L+L+
Sbjct: 397 DFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLE 456
Query: 807 GNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALN 847
N L+ LP ++ + L+K LV+ ++ TLP + N
Sbjct: 457 ENKLESLPNEIAYLKDLQK--LVLTNNQLTTLPRGIGHLTN 495
Score = 80.9 bits (198), Expect = 5e-15
Identities = 55/178 (30%), Positives = 96/178 (53%), Gaps = 5/178 (2%)
Query: 666 KSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAV 725
KS+N I+E+ + + L L I +P SI + L LY +NKL+SLP V
Sbjct: 84 KSSNAEVIKELNKCREENSMR-LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEV 142
Query: 726 FSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
L L L +S N+++ +P + L+ L+ L + NK+ +P +++ L TL L N
Sbjct: 143 GCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFN 202
Query: 786 CITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQ-CRMLKKSGLVVEDHLFDTLPLEV 842
IT++ + + LS+L+ L ++ N + +LPA++G+ C ++ L V + + LP E+
Sbjct: 203 RITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLIT---LDVAHNQLEHLPKEI 257
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 117 bits (292), Expect = 6e-26
Identities = 89/323 (27%), Positives = 161/323 (49%), Gaps = 31/323 (9%)
Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
LR L + D++ +P + L NL+EL + S+N E+++ + L I+ N
Sbjct: 71 LRKLSIPDNDLSNLPTTIASLVNLKELDI-----SKNGVQEFPENIKCCKCLTIIEASVN 125
Query: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
++K+P T + +LT+L +++ + L N +++ + LEL+ L+ +P ++ L
Sbjct: 126 PISKLPDGFTQLL-NLTQLYLNDAFLEFLPAN-FGRLVKLRILELRENHLKTLPKSMHKL 183
Query: 658 SNLQELDLKSNNIRTIEEII---------------------SFQHLKRLTCLKLWHNKIV 696
+ L+ LDL +N + E++ S LK L L + N+I
Sbjct: 184 AQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIE 243
Query: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
T+ I+ + LE L S+N L+ LP ++ L+KL L V N ++M+P IG L L+
Sbjct: 244 TVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEE 303
Query: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
+ N+++ LP + LRTL + +N + LP ++G +T + L+ N L+ LP +
Sbjct: 304 FDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEE 363
Query: 817 LGQCRMLKKSGLVVEDHLFDTLP 839
+GQ + L+ L + D+ LP
Sbjct: 364 IGQMQKLRV--LNLSDNRLKNLP 384
Score = 107 bits (266), Expect = 6e-23
Identities = 95/378 (25%), Positives = 174/378 (46%), Gaps = 42/378 (11%)
Query: 455 WTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514
+ FE+ + + +A +EL P +F+ L L + + +P I+ + N
Sbjct: 42 FNFERTLEELYLDANQIEEL--------PKQLFNCQALRKLSIPDNDLSNLPTTIASLVN 93
Query: 515 LQELHLCHCPAKVEQTAFSFLRDHLRC------LHVKFTDVAEIPAWVYLLKNLRELYL- 567
L+EL + + ++++C + ++++P L NL +LYL
Sbjct: 94 LKELD-------ISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 146
Query: 568 ----------IGNLNS-------ENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVA 610
G L EN+ +S+ +L L+ L + +N + D
Sbjct: 147 DAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQI 206
Query: 611 PHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNI 670
+L +L + N+ ++L S+ K+ + L++ +E + I L++L L SN +
Sbjct: 207 QNLRELWMDNNALQVLP-GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNML 265
Query: 671 RTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQK 730
+ + + I LK+LT LK+ N++ +P +I ++ LE S N+LESLP + L
Sbjct: 266 QQLPDSIGL--LKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHS 323
Query: 731 LRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSL 790
LR L V N + +P EIG +N+ + + NK++ LP+++ + KLR LNL N + +L
Sbjct: 324 LRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNL 383
Query: 791 PEKVGQLSQLTQLELKGN 808
P +L +L L L N
Sbjct: 384 PFSFTKLKELAALWLSDN 401
Score = 77.8 bits (190), Expect = 4e-14
Identities = 52/156 (33%), Positives = 80/156 (51%), Gaps = 3/156 (1%)
Query: 685 LTCLKLWHNKIVTIPPSITHV-KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
++ L H + +P + + + LE LY N++E LP +F+ Q LR L + N++S
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
Query: 744 IPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQL 803
+P I L NL+ L I+ N V P+ + C L + N I+ LP+ QL LTQL
Sbjct: 84 LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143
Query: 804 ELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
L L+ LPA G R++K L + ++ TLP
Sbjct: 144 YLNDAFLEFLPANFG--RLVKLRILELRENHLKTLP 177
Score = 77.8 bits (190), Expect = 4e-14
Identities = 73/291 (25%), Positives = 134/291 (46%), Gaps = 21/291 (7%)
Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQ-----ELHLCHCPAKVEQTAFS 533
+S +PD L +L L L +PA ++ L+ E HL P + + A
Sbjct: 127 ISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLA-- 184
Query: 534 FLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLE-SLRELRHLKI 592
L L + + E+P + ++NLREL++ +NN + L S+ +L+ L
Sbjct: 185 ----QLERLDLGNNEFGELPEVLDQIQNLRELWM------DNNALQVLPGSIGKLKMLVY 234
Query: 593 LHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPH 652
L + N + L L++ ++ + L +S+ + + L++ + +L +P+
Sbjct: 235 LDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLP-DSIGLLKKLTTLKVDDNQLTMLPN 293
Query: 653 AIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLY 712
I +LS L+E D N + ++ I + H L L + N + +P I KN+ +
Sbjct: 294 TIGNLSLLEEFDCSCNELESLPSTIGYLH--SLRTLAVDENFLPELPREIGSCKNVTVMS 351
Query: 713 FSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNK 763
+NKLE LP + +QKLR L++S N + +P L+ L L ++ N+
Sbjct: 352 LRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402
Score = 72.0 bits (175), Expect = 2e-12
Identities = 58/226 (25%), Positives = 101/226 (44%), Gaps = 49/226 (21%)
Query: 637 VAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV 696
++ L+ +C L+++P +F+ RT+EE L L N+I
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFE------------RTLEE------------LYLDANQIE 59
Query: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNN---------------- 740
+P + + + L L +N L +LP + SL L+ LD+S N
Sbjct: 60 ELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTI 119
Query: 741 -------ISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEK 793
IS +P L NL L++ ++ LP + +KLR L L +N + +LP+
Sbjct: 120 IEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS 179
Query: 794 VGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
+ +L+QL +L+L N LP L Q + L++ L ++++ LP
Sbjct: 180 MHKLAQLERLDLGNNEFGELPEVLDQIQNLRE--LWMDNNALQVLP 223
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 110 bits (276), Expect = 4e-24
Identities = 87/323 (26%), Positives = 153/323 (47%), Gaps = 31/323 (9%)
Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
L L + D+ +PA + L NLREL + S+N E+++ + L I+ N
Sbjct: 71 LHKLSLPDNDLTTLPASIANLINLRELDV-----SKNGIQEFPENIKNCKVLTIVEASVN 125
Query: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
++K+P + + +LT+L +++ + L N ++ + LEL+ +L+ +P + L
Sbjct: 126 PISKLPDGFSQLL-NLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRL 183
Query: 658 SNLQELDLKSNNIRTIEEIIS---------------------FQHLKRLTCLKLWHNKIV 696
+ L+ LDL SN + E++ LK+LT L + N I
Sbjct: 184 TQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIE 243
Query: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
+ I+ +NL+ L S+N L+ LP + SL+ + L + N + +P IG L +++
Sbjct: 244 MVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303
Query: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
L + N+V+ LP + + LRT N + LP ++G +T L L N L+ LP +
Sbjct: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363
Query: 817 LGQCRMLKKSGLVVEDHLFDTLP 839
+G + LK L D+ LP
Sbjct: 364 MGDMQKLKVINL--SDNRLKNLP 384
Score = 110 bits (274), Expect = 7e-24
Identities = 100/380 (26%), Positives = 175/380 (46%), Gaps = 46/380 (12%)
Query: 455 WTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514
+TFEK + + +A +EL P +F+ L L L +PA I+ + N
Sbjct: 42 FTFEKTLEELYLDANQIEEL--------PKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93
Query: 515 LQELHLC-----HCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYL-- 567
L+EL + P ++ L + ++++P L NL +LYL
Sbjct: 94 LRELDVSKNGIQEFPENIKNCKV------LTIVEASVNPISKLPDGFSQLLNLTQLYLND 147
Query: 568 ---------IGNLNS-------ENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVA 610
G L EN + +++ L L+ L + SN T+VP +V
Sbjct: 148 AFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP----EVL 203
Query: 611 PHLTKLV-IHNDGTKLLVLNS-LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSN 668
L+ L D +L + + + + L++ +E + I + NLQ+L L SN
Sbjct: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
Query: 669 NIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSL 728
+++ + E I LK +T LK+ N+++ +P SI + ++E L S N++E+LP ++ L
Sbjct: 264 SLQQLPETIG--SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321
Query: 729 QKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCIT 788
LR +N + +P EIG +N+ L + NK++ LP+++ KL+ +NL N +
Sbjct: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
Query: 789 SLPEKVGQLSQLTQLELKGN 808
+LP +L QLT + L N
Sbjct: 382 NLPFSFTKLQQLTAMWLSDN 401
Score = 89.0 bits (219), Expect = 2e-17
Identities = 74/285 (25%), Positives = 135/285 (47%), Gaps = 9/285 (3%)
Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
+S +PD L +L L L +PA ++T LQ L L K+ + L
Sbjct: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQ- 185
Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
L L + + E+P + L L+E ++ N + IG SL++L +L + K+N
Sbjct: 186 LERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG--SLKQLTYLDVS--KNN 241
Query: 599 LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658
+ V I+ +L L++ ++ + L ++ + N+ L++ +L +P +I L
Sbjct: 242 IEMVEEGIS-TCENLQDLLLSSNSLQQLP-ETIGSLKNITTLKIDENQLMYLPDSIGGLI 299
Query: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
+++ELD N + + I L L HN + +PP I KN+ L+ +NKL
Sbjct: 300 SVEELDCSFNEVEALPSSIG--QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
Query: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNK 763
E+LP + +QKL+ +++S N + +P LQ L + ++ N+
Sbjct: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
Score = 77.4 bits (189), Expect = 5e-14
Identities = 51/156 (32%), Positives = 77/156 (49%), Gaps = 3/156 (1%)
Query: 685 LTCLKLWHNKIVTIPPSI-THVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
+T L H + +P I T K LE LY N++E LP +F+ Q L L + N+++
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
Query: 744 IPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQL 803
+P I L NL+ L ++ N + P+ + C L + N I+ LP+ QL LTQL
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
Query: 804 ELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
L L+ LPA G R+ K L + ++ LP
Sbjct: 144 YLNDAFLEFLPANFG--RLTKLQILELRENQLKMLP 177
Score = 69.7 bits (169), Expect = 1e-11
Identities = 54/192 (28%), Positives = 87/192 (45%), Gaps = 24/192 (12%)
Query: 637 VAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV 696
V L+ +C LE++P IF+ +T+EE L L N+I
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFE------------KTLEE------------LYLDANQIE 59
Query: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
+P + + ++L L +N L +LP ++ +L LR LDVS N I P I + L
Sbjct: 60 ELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTI 119
Query: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
+ + N + LP + + L L L + LP G+L++L LEL+ N L LP
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
Query: 817 LGQCRMLKKSGL 828
+ + L++ L
Sbjct: 180 MNRLTQLERLDL 191
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 110 bits (276), Expect = 4e-24
Identities = 87/323 (26%), Positives = 153/323 (47%), Gaps = 31/323 (9%)
Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
L L + D+ +PA + L NLREL + S+N E+++ + L I+ N
Sbjct: 71 LHKLSLPDNDLTTLPASIANLINLRELDV-----SKNGIQEFPENIKNCKVLTIVEASVN 125
Query: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
++K+P + + +LT+L +++ + L N ++ + LEL+ +L+ +P + L
Sbjct: 126 PISKLPDGFSQLL-NLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRL 183
Query: 658 SNLQELDLKSNNIRTIEEIIS---------------------FQHLKRLTCLKLWHNKIV 696
+ L+ LDL SN + E++ LK+LT L + N I
Sbjct: 184 TQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIE 243
Query: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
+ I+ +NL+ L S+N L+ LP + SL+ + L + N + +P IG L +++
Sbjct: 244 MVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303
Query: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
L + N+V+ LP + + LRT N + LP ++G +T L L N L+ LP +
Sbjct: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363
Query: 817 LGQCRMLKKSGLVVEDHLFDTLP 839
+G + LK L D+ LP
Sbjct: 364 MGDMQKLKVINL--SDNRLKNLP 384
Score = 110 bits (274), Expect = 7e-24
Identities = 100/380 (26%), Positives = 175/380 (46%), Gaps = 46/380 (12%)
Query: 455 WTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514
+TFEK + + +A +EL P +F+ L L L +PA I+ + N
Sbjct: 42 FTFEKTLEELYLDANQIEEL--------PKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93
Query: 515 LQELHLC-----HCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYL-- 567
L+EL + P ++ L + ++++P L NL +LYL
Sbjct: 94 LRELDVSKNGIQEFPENIKNCKV------LTIVEASVNPISKLPDGFSQLLNLTQLYLND 147
Query: 568 ---------IGNLNS-------ENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVA 610
G L EN + +++ L L+ L + SN T+VP +V
Sbjct: 148 AFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP----EVL 203
Query: 611 PHLTKLV-IHNDGTKLLVLNS-LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSN 668
L+ L D +L + + + + L++ +E + I + NLQ+L L SN
Sbjct: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
Query: 669 NIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSL 728
+++ + E I LK +T LK+ N+++ +P SI + ++E L S N++E+LP ++ L
Sbjct: 264 SLQQLPETIG--SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321
Query: 729 QKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCIT 788
LR +N + +P EIG +N+ L + NK++ LP+++ KL+ +NL N +
Sbjct: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
Query: 789 SLPEKVGQLSQLTQLELKGN 808
+LP +L QLT + L N
Sbjct: 382 NLPFSFTKLQQLTAMWLSDN 401
Score = 89.0 bits (219), Expect = 2e-17
Identities = 74/285 (25%), Positives = 135/285 (47%), Gaps = 9/285 (3%)
Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
+S +PD L +L L L +PA ++T LQ L L K+ + L
Sbjct: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQ- 185
Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
L L + + E+P + L L+E ++ N + IG SL++L +L + K+N
Sbjct: 186 LERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG--SLKQLTYLDVS--KNN 241
Query: 599 LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658
+ V I+ +L L++ ++ + L ++ + N+ L++ +L +P +I L
Sbjct: 242 IEMVEEGIS-TCENLQDLLLSSNSLQQLP-ETIGSLKNITTLKIDENQLMYLPDSIGGLI 299
Query: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
+++ELD N + + I L L HN + +PP I KN+ L+ +NKL
Sbjct: 300 SVEELDCSFNEVEALPSSIG--QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
Query: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNK 763
E+LP + +QKL+ +++S N + +P LQ L + ++ N+
Sbjct: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
Score = 77.4 bits (189), Expect = 5e-14
Identities = 51/156 (32%), Positives = 77/156 (49%), Gaps = 3/156 (1%)
Query: 685 LTCLKLWHNKIVTIPPSI-THVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
+T L H + +P I T K LE LY N++E LP +F+ Q L L + N+++
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
Query: 744 IPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQL 803
+P I L NL+ L ++ N + P+ + C L + N I+ LP+ QL LTQL
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
Query: 804 ELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
L L+ LPA G R+ K L + ++ LP
Sbjct: 144 YLNDAFLEFLPANFG--RLTKLQILELRENQLKMLP 177
Score = 69.7 bits (169), Expect = 1e-11
Identities = 54/192 (28%), Positives = 87/192 (45%), Gaps = 24/192 (12%)
Query: 637 VAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV 696
V L+ +C LE++P IF+ +T+EE L L N+I
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFE------------KTLEE------------LYLDANQIE 59
Query: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
+P + + ++L L +N L +LP ++ +L LR LDVS N I P I + L
Sbjct: 60 ELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTI 119
Query: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
+ + N + LP + + L L L + LP G+L++L LEL+ N L LP
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
Query: 817 LGQCRMLKKSGL 828
+ + L++ L
Sbjct: 180 MNRLTQLERLDL 191
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 110 bits (274), Expect = 7e-24
Identities = 65/185 (35%), Positives = 101/185 (54%), Gaps = 25/185 (13%)
Query: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
N E+D+ I + ++ L +T L L HNK+ +PP+I +KNLE L F NN++
Sbjct: 16 NQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQI 75
Query: 719 ESLPVAVFSLQKLR-----------------------CLDVSYNNIS--MIPIEIGLLQN 753
E LP + SLQKL+ LD++YNN+S +P L
Sbjct: 76 EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135
Query: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRL 813
L+ L+++ N +ILP + K KL+ L+L N + SLP+++G+L+QL +L ++GN L L
Sbjct: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195
Query: 814 PAQLG 818
P +LG
Sbjct: 196 PPELG 200
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/197 (28%), Positives = 90/197 (45%), Gaps = 26/197 (13%)
Query: 576 NKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKM 634
+ M+ + L L H+ L + N LT VP NI ++ +L L N+ + L + +
Sbjct: 28 SNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELK-NLEVLNFFNNQIEELP-TQISSL 85
Query: 635 MNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNK 694
+ L L L +P SL L+ LDL NN+
Sbjct: 86 QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE---------------------- 123
Query: 695 IVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNL 754
++P + ++ L +LY S+N E LP + L KL+ L + N++ +P EIG L L
Sbjct: 124 -NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQL 182
Query: 755 QHLHITGNKVDILPKQL 771
+ LHI GN++ +LP +L
Sbjct: 183 KELHIQGNRLTVLPPEL 199
Score = 40.8 bits (94), Expect = 0.005
Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 2/108 (1%)
Query: 734 LDVSYNNISMIPIEIGL--LQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLP 791
+D+S IS + GL L ++ L ++ NK+ ++P + + L LN N I LP
Sbjct: 20 VDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELP 79
Query: 792 EKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
++ L +L L L N L+ LP G L+ L + ++LP
Sbjct: 80 TQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLP 127
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 110 bits (274), Expect = 7e-24
Identities = 98/341 (28%), Positives = 166/341 (48%), Gaps = 12/341 (3%)
Query: 479 LSGVPDAVFDLT-DLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPA-KVEQTAFSFLR 536
L VP+ ++ + L+ L L+ ++P ++ NL++L L ++ +F++
Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
Query: 537 DHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVK 596
L L V D+ EIP + K L GN S G LR L HL + V
Sbjct: 84 --LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPD--GFTQLRSLAHLALNDV- 138
Query: 597 SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 656
+L +P ++ ++A +L L + + K L SL ++ + +L+L +LE +P + +
Sbjct: 139 -SLQALPGDVGNLA-NLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTLGA 195
Query: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNN 716
L NL+EL L N + + + +L+RL CL + N++ +P + + L L S N
Sbjct: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
Query: 717 KLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIK 776
L LP + L++L L V N + + IG +NL L +T N + LP+ L K K
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
Query: 777 LRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQL 817
L LN+ +N + +LP ++G L+ L L+ N L LP +L
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPEL 354
Score = 95.5 bits (236), Expect = 2e-19
Identities = 79/287 (27%), Positives = 132/287 (45%), Gaps = 49/287 (17%)
Query: 598 NLTKVPSNITDVAPHLTKLVIHNDGTKLLVL-NSLKKMMNVAELELQNCELERIPHAIFS 656
+L VP I + L +L++ D +L L +++N+ +L L + E++R+P + +
Sbjct: 23 SLQAVPEEIYRYSRSLEELLL--DANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVAN 80
Query: 657 LSNLQELDLKSNNIRTIEEIISF------------------------------------- 679
L ELD+ N+I I E I F
Sbjct: 81 FMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSL 140
Query: 680 -------QHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLR 732
+L L L+L N + ++P S++ + LE L N LE LP + +L LR
Sbjct: 141 QALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLR 200
Query: 733 CLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPE 792
L + N +S +P E+G L+ L L ++ N+++ LP +L + L L L QN + LP+
Sbjct: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260
Query: 793 KVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
+GQL QL+ L++ N L + +G C L S L++ ++L LP
Sbjct: 261 GIGQLKQLSILKVDQNRLCEVTEAIGDCENL--SELILTENLLMALP 305
Score = 64.3 bits (155), Expect = 5e-10
Identities = 73/273 (26%), Positives = 115/273 (42%), Gaps = 32/273 (11%)
Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
LS +PD L L L L + +P + + NL L L K + SFL
Sbjct: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK- 175
Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLE-SLRELRHLKILHVKS 597
L L + D+ +P + L NLREL+L + N++ L L LR L L V
Sbjct: 176 LEQLDLGGNDLEVLPDTLGALPNLRELWL------DRNQLSALPPELGNLRRLVCLDVSE 229
Query: 598 N-LTKVPSNITDVAPHLTKLVIHN------DGTKLLVLNSLKKM---------------M 635
N L ++P+ + + L+ N DG L S+ K+
Sbjct: 230 NRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCE 289
Query: 636 NVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKI 695
N++EL L L +P ++ L+ L L++ N++ + I L+ L L N++
Sbjct: 290 NLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIG--GCVALSVLSLRDNRL 347
Query: 696 VTIPPSITHVKNLESLYFSNNKLESLPVAVFSL 728
+PP + H L L + N+L+SLP A+ L
Sbjct: 348 AVLPPELAHTTELHVLDVAGNRLQSLPFALTHL 380
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 110 bits (274), Expect = 7e-24
Identities = 98/341 (28%), Positives = 166/341 (48%), Gaps = 12/341 (3%)
Query: 479 LSGVPDAVFDLT-DLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPA-KVEQTAFSFLR 536
L VP+ ++ + L+ L L+ ++P ++ NL++L L ++ +F++
Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
Query: 537 DHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVK 596
L L V D+ EIP + K L GN S G LR L HL + V
Sbjct: 84 --LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPD--GFTQLRSLAHLALNDV- 138
Query: 597 SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 656
+L +P ++ ++A +L L + + K L SL ++ + +L+L +LE +P + +
Sbjct: 139 -SLQALPGDVGNLA-NLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTLGA 195
Query: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNN 716
L NL+EL L N + + + +L+RL CL + N++ +P + + L L S N
Sbjct: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
Query: 717 KLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIK 776
L LP + L++L L V N + + IG +NL L +T N + LP+ L K K
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
Query: 777 LRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQL 817
L LN+ +N + +LP ++G L+ L L+ N L LP +L
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPEL 354
Score = 95.5 bits (236), Expect = 2e-19
Identities = 79/287 (27%), Positives = 132/287 (45%), Gaps = 49/287 (17%)
Query: 598 NLTKVPSNITDVAPHLTKLVIHNDGTKLLVL-NSLKKMMNVAELELQNCELERIPHAIFS 656
+L VP I + L +L++ D +L L +++N+ +L L + E++R+P + +
Sbjct: 23 SLQAVPEEIYRYSRSLEELLL--DANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVAN 80
Query: 657 LSNLQELDLKSNNIRTIEEIISF------------------------------------- 679
L ELD+ N+I I E I F
Sbjct: 81 FMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSL 140
Query: 680 -------QHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLR 732
+L L L+L N + ++P S++ + LE L N LE LP + +L LR
Sbjct: 141 QALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLR 200
Query: 733 CLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPE 792
L + N +S +P E+G L+ L L ++ N+++ LP +L + L L L QN + LP+
Sbjct: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260
Query: 793 KVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
+GQL QL+ L++ N L + +G C L S L++ ++L LP
Sbjct: 261 GIGQLKQLSILKVDQNRLCEVTEAIGDCENL--SELILTENLLMALP 305
Score = 64.3 bits (155), Expect = 5e-10
Identities = 73/273 (26%), Positives = 115/273 (42%), Gaps = 32/273 (11%)
Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
LS +PD L L L L + +P + + NL L L K + SFL
Sbjct: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK- 175
Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLE-SLRELRHLKILHVKS 597
L L + D+ +P + L NLREL+L + N++ L L LR L L V
Sbjct: 176 LEQLDLGGNDLEVLPDTLGALPNLRELWL------DRNQLSALPPELGNLRRLVCLDVSE 229
Query: 598 N-LTKVPSNITDVAPHLTKLVIHN------DGTKLLVLNSLKKM---------------M 635
N L ++P+ + + L+ N DG L S+ K+
Sbjct: 230 NRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCE 289
Query: 636 NVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKI 695
N++EL L L +P ++ L+ L L++ N++ + I L+ L L N++
Sbjct: 290 NLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIG--GCVALSVLSLRDNRL 347
Query: 696 VTIPPSITHVKNLESLYFSNNKLESLPVAVFSL 728
+PP + H L L + N+L+SLP A+ L
Sbjct: 348 AVLPPELAHTTELHVLDVAGNRLQSLPFALTHL 380
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 109 bits (273), Expect = 9e-24
Identities = 108/400 (27%), Positives = 190/400 (47%), Gaps = 39/400 (9%)
Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCH------CPA------- 525
L+ +P +F T+L+ + LE +IP +I ++ N++ L+L CPA
Sbjct: 37 LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96
Query: 526 -----------KVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSE 574
SFL LR L + TD+ EIP V + KNL L L+G L
Sbjct: 97 ESLDLSYNPIFSSSLVVVSFLHA-LRELRLYQTDLKEIP--VVIFKNLHHLELLG-LTGN 152
Query: 575 NNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKL-LVLNSLKK 633
+ K + E + + + L+ +++K N +V ++ T +I D K+ + +
Sbjct: 153 HLKCLPKEIVNQTK-LREIYLKRNQFEVFPQ--ELCVLYTLEIIDLDENKIGAIPEEIGH 209
Query: 634 MMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHN 693
+ + + + + L +P ++ S L LDL N + +I + SF L+++T + L N
Sbjct: 210 LTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPK--SFAELRKMTEIGLSGN 267
Query: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
++ +P I +L LY N L L + L LR LD+S N++ P++I L+N
Sbjct: 268 RLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKN 327
Query: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLEL---KGNCL 810
L+ L + NK+ LP +L KL+ L L N S PE+V L+ L +L + +G L
Sbjct: 328 LEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKL 387
Query: 811 DRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDI 850
+P + + + LK+ L +E++ + LP+ + N ++
Sbjct: 388 TYVPEHIRKLQSLKE--LYIENNHLEYLPVSLGSMPNLEV 425
Score = 90.9 bits (224), Expect = 5e-18
Identities = 97/372 (26%), Positives = 165/372 (44%), Gaps = 32/372 (8%)
Query: 472 QELHLFM--LSGVPDAVF-DLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVE 528
+EL L+ L +P +F +L L++L L +P +I T L+E++L +V
Sbjct: 121 RELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVF 180
Query: 529 QTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN-----------------L 571
L L + + + IP + L L++ Y+ N L
Sbjct: 181 PQELCVLYT-LEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVL 239
Query: 572 NSENNKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITD-VAPHLTKLVIHNDGTKLLVL 628
+ +N + + +S ELR + + + N L KVP I + HL L + N G L
Sbjct: 240 DLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHL--LYLGNTGLHRL-R 296
Query: 629 NSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCL 688
S + ++N+ L+L L P I +L NL+ L L N I + + L +L L
Sbjct: 297 GSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELG--SLSKLKIL 354
Query: 689 KLWHNKIVTIPPSITHVKNLESLYFSNN---KLESLPVAVFSLQKLRCLDVSYNNISMIP 745
L N+ ++ P + + +LE LY + KL +P + LQ L+ L + N++ +P
Sbjct: 355 GLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLP 414
Query: 746 IEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLEL 805
+ +G + NL+ L N + LP + + L+ L L N +T LPE + L L L L
Sbjct: 415 VSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTL 474
Query: 806 KGNCLDRLPAQL 817
N ++ P ++
Sbjct: 475 MDNPMEEPPKEV 486
Score = 85.5 bits (210), Expect = 2e-16
Identities = 64/230 (27%), Positives = 113/230 (49%), Gaps = 29/230 (12%)
Query: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
++ N L IP IF+ + L+E+ L++N I I + I Q LK + L L N + ++
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEI--QRLKNIRVLYLDKNNLRSLC 87
Query: 700 PSITHVKNLESLYFSNN------------------------KLESLPVAVF-SLQKLRCL 734
P++ + +LESL S N L+ +PV +F +L L L
Sbjct: 88 PALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELL 147
Query: 735 DVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKV 794
++ N++ +P EI L+ +++ N+ ++ P++L L ++L +N I ++PE++
Sbjct: 148 GLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEI 207
Query: 795 GQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKE 844
G L+ L + + N L LPA L QC L S L + +L ++P E
Sbjct: 208 GHLTGLQKFYMASNNLPVLPASLCQCSQL--SVLDLSHNLLHSIPKSFAE 255
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 105 bits (263), Expect = 1e-22
Identities = 90/333 (27%), Positives = 152/333 (45%), Gaps = 57/333 (17%)
Query: 480 SGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHL 539
SGVPD +F L DL VL L + P ++ N+ L+L H L
Sbjct: 94 SGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDL 153
Query: 540 RCLHVKFTDVAEIPAWVYLLKNLRELYLIGN--LNSENNKMIGLESLRELRHLKILHVKS 597
L + + +P + L +L+ L L GN L+++ L L + L+ LH++S
Sbjct: 154 LYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQ------LRQLPAMTALQTLHLRS 207
Query: 598 NLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
+ SN+ SL+ + N+A+++L +L R+P +++L
Sbjct: 208 T-QRTQSNLP---------------------TSLEGLSNLADVDLSCNDLTRVPECLYTL 245
Query: 658 SNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
+L+ L+L SN I + C+ W HV E+L S N+
Sbjct: 246 PSLRRLNLSSNQITELS-----------LCIDQW-----------VHV---ETLNLSRNQ 280
Query: 718 LESLPVAVFSLQKLRCLDVSYNNISM--IPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 775
L SLP A+ L KL+ L ++ N + +P IG L NL+ N ++++P+ L +C
Sbjct: 281 LTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCP 340
Query: 776 KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGN 808
KLR L L +N + +LPE + L+++ L+++ N
Sbjct: 341 KLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373
Score = 90.9 bits (224), Expect = 5e-18
Identities = 72/274 (26%), Positives = 141/274 (51%), Gaps = 33/274 (12%)
Query: 581 LESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLL-VLNSLKKMMNVAE 639
L +L++L HL + H +NLT + ++ + P L +V + K V + + K+ +++
Sbjct: 52 LAALQKLEHLSVSH--NNLTTLHGELSSL-PSLRAIVARANSLKNSGVPDDIFKLDDLSV 108
Query: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
L+L + +L P + + N+ L+L N+I TI + F +L L L L N++ ++P
Sbjct: 109 LDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQL-FINLTDLLYLDLSENRLESLP 167
Query: 700 PSITHVKNLESLYFSNNKL--------------------------ESLPVAVFSLQKLRC 733
P + + +L++L + N L +LP ++ L L
Sbjct: 168 PQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLAD 227
Query: 734 LDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEK 793
+D+S N+++ +P + L +L+ L+++ N++ L + + + + TLNL +N +TSLP
Sbjct: 228 VDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSA 287
Query: 794 VGQLSQLTQLELKGNCL--DRLPAQLGQCRMLKK 825
+ +LS+L +L L N L D LP+ +G+ L++
Sbjct: 288 ICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEE 321
Score = 84.0 bits (206), Expect = 6e-16
Identities = 88/368 (23%), Positives = 164/368 (44%), Gaps = 48/368 (13%)
Query: 483 PDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCL 542
P+ V +T L LKL +P +++ + L+ L + H ++L L
Sbjct: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSH--------------NNLTTL 71
Query: 543 HVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN-LTK 601
H + + + + A ++ NS N + + + +L L +L + N LT+
Sbjct: 72 HGELSSLPSLRA------------IVARANSLKNSGVP-DDIFKLDDLSVLDLSHNQLTE 118
Query: 602 VPSNITDVAPHLTKLVIHNDGTKL---LVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658
P + + L + HN + L +N + ++ L+L LE +P + L
Sbjct: 119 CPRELENAKNMLVLNLSHNSIDTIPNQLFIN----LTDLLYLDLSENRLESLPPQMRRLV 174
Query: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV-----TIPPSITHVKNLESLYF 713
+LQ L L N + + + L +T L+ H + +P S+ + NL +
Sbjct: 175 HLQTLVLNGNPLLHAQ----LRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDL 230
Query: 714 SNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFK 773
S N L +P +++L LR L++S N I+ + + I +++ L+++ N++ LP + K
Sbjct: 231 SCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICK 290
Query: 774 CIKLRTLNLGQNCIT--SLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVE 831
KL+ L L N + LP +G+L+ L + N L+ +P L +C L+K LV+
Sbjct: 291 LSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRK--LVLN 348
Query: 832 DHLFDTLP 839
+ TLP
Sbjct: 349 KNHLVTLP 356
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 105 bits (262), Expect = 2e-22
Identities = 105/394 (26%), Positives = 184/394 (46%), Gaps = 48/394 (12%)
Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQEL-----HLCHCPAKVEQTAFS 533
LS +P + L +L +L + + IP +ISQ+ N+++L ++ + P+ +E
Sbjct: 200 LSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLG-- 257
Query: 534 FLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGL-ESLRELRHLKI 592
+L L + + IP + LK LR L N E N++ ++L L L
Sbjct: 258 ----NLEILSLGKNKLRHIPDTLPSLKTLRVL------NLEYNQLTTFPKALCFLPKLIS 307
Query: 593 LHVKSNL-TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIP 651
L + NL + +P I ++ T L+ HN T L V + +++ + EL+L + +LE I
Sbjct: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAV--EIFQLLKIKELQLADNKLEVIS 365
Query: 652 HAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPP----------- 700
H I + L+ L L N ++ I E IS + L CL L NK+ +P
Sbjct: 366 HKIENFRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLRKL 423
Query: 701 ------------SITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEI 748
I+H+ N+ SL FS N + +P+ + + QK+ +++SYN I P+ +
Sbjct: 424 HVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGL 483
Query: 749 GLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGN 808
L +L +L + GN + +P + +L L L +N + E L L L+L N
Sbjct: 484 CALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKN 543
Query: 809 CLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEV 842
+ ++PA + M+ L++ + F+T P E+
Sbjct: 544 QIKKIPASIS--NMISLHVLILCCNKFETFPREL 575
Score = 102 bits (253), Expect = 2e-21
Identities = 101/387 (26%), Positives = 167/387 (43%), Gaps = 47/387 (12%)
Query: 441 VSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELI 500
+S+NKL E+ + H++RN K + D + L ++ L+
Sbjct: 402 LSDNKLTELPKYIHKLNNLRKLHVNRNNMVK----------ITDCISHLNNICSLEFSGN 451
Query: 501 PEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLK 560
+P +I + ++ L + L D L L V ++EIP + K
Sbjct: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL-DSLYYLSVNGNYISEIPVDISFSK 510
Query: 561 NLRELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIH 619
L L L SEN +I E L +LK L + K+ + K+P++I++
Sbjct: 511 QLLHLEL-----SENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISN----------- 554
Query: 620 NDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISF 679
M+++ L L + E P + +L NLQ LDL N ++ I I
Sbjct: 555 --------------MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDIC- 599
Query: 680 QHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSN---NKLESLPVAVFSLQKLRCLDV 736
+LK + L N+ + P + +++LE L S KL LP + ++ +L+ LD+
Sbjct: 600 -NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDI 658
Query: 737 SYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQ 796
S N I IP IG L+NL LH N++ LP L L+ LNL N +T+LP +
Sbjct: 659 SNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYN 718
Query: 797 LSQLTQLELKGNCLDRLPAQLGQCRML 823
+ L ++ N L R P ++ + + L
Sbjct: 719 IFSLKEINFDDNPLLRPPVEICKGKQL 745
Score = 98.6 bits (244), Expect = 2e-20
Identities = 76/276 (27%), Positives = 137/276 (49%), Gaps = 9/276 (3%)
Query: 551 EIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDV 609
E P + +K ++ LYL N + G +S +L L+IL ++ N L+ +PS I +
Sbjct: 155 EFPKDILKIKYVKYLYLDKN---QIKTFQGADS-GDLLGLEILSLQENGLSSLPSEIQLL 210
Query: 610 APHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNN 669
V HN + + + ++ N+ +L N +E P + L NL+ L L N
Sbjct: 211 HNLRILNVSHNHISH--IPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNK 268
Query: 670 IRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQ 729
+R I + + LK L L L +N++ T P ++ + L SL + N + SLP + L+
Sbjct: 269 LRHIPDTLP--SLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK 326
Query: 730 KLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITS 789
L L + +N ++ + +EI L ++ L + NK++++ ++ +LR L L +N + +
Sbjct: 327 NLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKN 386
Query: 790 LPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKK 825
+PEK+ + L L L N L LP + + L+K
Sbjct: 387 IPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRK 422
Score = 93.2 bits (230), Expect = 9e-19
Identities = 99/418 (23%), Positives = 174/418 (41%), Gaps = 77/418 (18%)
Query: 478 MLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRD 537
++S +P + +L +L+ L ++ + +I Q+ ++EL L +V R+
Sbjct: 314 LISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRE 373
Query: 538 ----------------------HLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSEN 575
L CL + + E+P +++ L NLR+L++ + N
Sbjct: 374 LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV-----NRN 428
Query: 576 NKMIGLESLRELRHLKILHVKSNL-TKVPSNITDVAPHLTKLVIHN------------DG 622
N + + + L ++ L N+ T VP I + + + +N D
Sbjct: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488
Query: 623 TKLLVLNS---------LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTI 673
L +N + + LEL +L SL NL+ LDL N I+ I
Sbjct: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548
Query: 674 EEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRC 733
IS ++ L L L NK T P + ++NL+ L S N+L+ + + +L+ ++
Sbjct: 549 PASIS--NMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQK 606
Query: 734 LDVSYNNISMIPIEIGLLQNLQHLHIT---GNKVDILPKQLFKCIKLRTLNLGQNCITSL 790
L+ S N PIE+ LQ+L+ L+I+ G K+ LP +L +L+ L++ N I +
Sbjct: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666
Query: 791 PEKVGQL-----------------------SQLTQLELKGNCLDRLPAQLGQCRMLKK 825
P +G+L + L QL L GN L LP+ + LK+
Sbjct: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKE 724
Score = 76.6 bits (187), Expect = 9e-14
Identities = 99/420 (23%), Positives = 167/420 (39%), Gaps = 64/420 (15%)
Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
L +PD + L L VL LE P + + L L L S L
Sbjct: 269 LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTG-------NLISSLPKE 321
Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKM-IGLESLRELRHLKILHVKS 597
+R L T + + +L + +L I L +NK+ + + R L+IL +
Sbjct: 322 IRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDK 381
Query: 598 NLTK-VPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 656
NL K +P I+ A + + + +D + + K+ N+ +L + + +I I
Sbjct: 382 NLLKNIPEKISCCA--MLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISH 439
Query: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV-------------------- 696
L+N+ L+ N I + I ++ +++ ++L +NKI+
Sbjct: 440 LNNICSLEFSGNIITDVP--IEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497
Query: 697 ---TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
IP I+ K L L S NKL SL L+ LD+ N I IP I + +
Sbjct: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
Query: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSL----------------------- 790
L L + NK + P++L L+ L+L +N + +
Sbjct: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617
Query: 791 PEKVGQLSQLTQL---ELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALN 847
P ++ QL L QL ++KG L RLP +L LK+ L + ++ +P + E N
Sbjct: 618 PIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKE--LDISNNAIREIPRNIGELRN 675
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 103 bits (258), Expect = 5e-22
Identities = 99/356 (27%), Positives = 173/356 (48%), Gaps = 23/356 (6%)
Query: 493 DVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEI 552
D L+ P+ +PA + +++ L+L + + LR L ++ A +
Sbjct: 46 DALESPASPQLVLPANLG---DIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARL 102
Query: 553 PAWVYLLKNLRELYLIGNLNSENNKMIGL-----ESLRELRHLKILHVKSNLTKVPSNIT 607
P V L + + L+ +N++ L +LRELR L + H + L +P+ +
Sbjct: 103 PPAVAELG-----HHLTELDVSHNRLTALGAEVVSALRELRKLNLSH--NQLPALPAQLG 155
Query: 608 DVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKS 667
+A HL +L + + L +SL + + L++ + +L P + L L+ELD+ S
Sbjct: 156 ALA-HLEELDVSFNRLAHLP-DSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSS 213
Query: 668 NNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFS 727
N +R + E IS L+ L L L ++ T+P + +LESL NN L++LP
Sbjct: 214 NRLRGLPEDISA--LRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSC 271
Query: 728 LQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCI 787
LQ+L+ L++S N P + L L+ L+++ N++ +P + +L TL L N I
Sbjct: 272 LQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRI 331
Query: 788 TSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGL-VVEDHLFDTLPLEV 842
LP+ + +L+ L +L L+GN + LP GQ L + GL ++D+ P EV
Sbjct: 332 RYLPDSIVELTGLEELVLQGNQIAVLPDHFGQ---LSRVGLWKIKDNPLIQPPYEV 384
Score = 87.8 bits (216), Expect = 4e-17
Identities = 76/261 (29%), Positives = 130/261 (49%), Gaps = 15/261 (5%)
Query: 602 VPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSN-L 660
+P+N+ D+ L + N+G + + + ++ L L+ R+P A+ L + L
Sbjct: 58 LPANLGDIEA----LNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHL 113
Query: 661 QELDLKSNNIRTI-EEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE 719
ELD+ N + + E++S L+ L L L HN++ +P + + +LE L S N+L
Sbjct: 114 TELDVSHNRLTALGAEVVSA--LRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 171
Query: 720 SLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRT 779
LP ++ L +LR LDV +N ++ P ++ L L+ L ++ N++ LP+ + L+
Sbjct: 172 HLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231
Query: 780 LNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ---LGQCRMLKKSGLVVEDHLFD 836
L L + +LP +L+ L L L N L LPAQ L + +ML S + E+
Sbjct: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
Query: 837 TLPLEVKEAL----NQDINIP 853
LPL E L NQ ++P
Sbjct: 292 LLPLAGLEELYLSRNQLTSVP 312
Score = 47.8 bits (112), Expect = 4e-05
Identities = 65/295 (22%), Positives = 115/295 (38%), Gaps = 56/295 (18%)
Query: 405 SFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHI 464
S + +P + L H+ ++ D +++ + S ++LR + ++H RQ +
Sbjct: 143 SHNQLPALPAQLGALAHL-EELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLL 201
Query: 465 SRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCP 524
A ++ ++ L G+P+ + L L +L L +PA ++ +L+ L L +
Sbjct: 202 QLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNG 261
Query: 525 AKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESL 584
+ FS L+ L+ L++ E PA + L L ELYL N
Sbjct: 262 LQALPAQFSCLQ-RLKMLNLSSNLFEEFPAALLPLAGLEELYLSRN-------------- 306
Query: 585 RELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQN 644
LT VPS I+ + LT L L N
Sbjct: 307 -------------QLTSVPSLISGLGRLLT-------------------------LWLDN 328
Query: 645 CELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
+ +P +I L+ L+EL L+ N I + + F L R+ K+ N ++ P
Sbjct: 329 NRIRYLPDSIVELTGLEELVLQGNQIAVLPD--HFGQLSRVGLWKIKDNPLIQPP 381
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 103 bits (258), Expect = 5e-22
Identities = 83/279 (29%), Positives = 145/279 (51%), Gaps = 11/279 (3%)
Query: 575 NNKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLK 632
NNK+ L + LR L L +L + N LT +PS I ++ +L KL + ++ K+L +
Sbjct: 91 NNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELE-NLQKLNVSHNKLKILP-EEIT 148
Query: 633 KMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWH 692
+ N+ L LQ+ EL I LSNL++LDL +N++ T+ SF L L L L
Sbjct: 149 NLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVP--ASFSSLSSLVRLNLSS 206
Query: 693 NKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQ 752
N++ ++P I +K L+ L ++N LE++P + ++ L L + N + +P E
Sbjct: 207 NELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP-EFPSCS 265
Query: 753 NLQHLHITGNKVDILPKQLFKCI-KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLD 811
L+ LH+ N++++L + K + + L+L N + S+P+++ L L +L+L N +
Sbjct: 266 LLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDIS 325
Query: 812 RLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDI 850
LP LG L L +E + T+ E+ Q++
Sbjct: 326 SLPYSLGN---LHLKFLALEGNPLRTIRREIISKGTQEV 361
Score = 89.4 bits (220), Expect = 1e-17
Identities = 63/235 (26%), Positives = 118/235 (50%), Gaps = 29/235 (12%)
Query: 613 LTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRT 672
LTKL+I N+ + L + L+ + + L++ + +L +P AI L NLQ+L++
Sbjct: 84 LTKLIISNNKLQSLT-DDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVS------ 136
Query: 673 IEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLR 732
HNK+ +P IT+++NL+ LY +N+L + L L
Sbjct: 137 -------------------HNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLE 177
Query: 733 CLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPE 792
LD+S N+++ +P L +L L+++ N++ LP ++ + +L+ L+ N + ++P
Sbjct: 178 DLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPP 237
Query: 793 KVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALN 847
++ + L L L+ N L LP + C +LK+ L V ++ + L E + LN
Sbjct: 238 ELAGMESLELLYLRRNKLRFLP-EFPSCSLLKE--LHVGENQIEMLEAEHLKHLN 289
Score = 85.9 bits (211), Expect = 1e-16
Identities = 46/167 (27%), Positives = 92/167 (55%), Gaps = 2/167 (1%)
Query: 658 SNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
++L +L + +N ++++ + + L LT L + N++ ++P +I ++NL+ L S+NK
Sbjct: 82 TDLTKLIISNNKLQSLTDDLRL--LPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNK 139
Query: 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKL 777
L+ LP + +L+ L+CL + +N ++ I L NL+ L ++ N + +P L
Sbjct: 140 LKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSL 199
Query: 778 RTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLK 824
LNL N + SLP ++ ++ +L L+ N L+ +P +L L+
Sbjct: 200 VRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLE 246
Score = 84.3 bits (207), Expect = 4e-16
Identities = 104/456 (22%), Positives = 201/456 (44%), Gaps = 109/456 (23%)
Query: 466 RNAQDKQELHLF--MLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHC 523
R ++ Q+L++ L +P+ + +L +L L L+ I Q++NL++L L +
Sbjct: 125 RELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNN 184
Query: 524 PAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNL-NSENNKMIGLE 582
+FS L +R L++ ++ +PA + +K L+ L NL + ++ G+E
Sbjct: 185 HLTTVPASFSSLSSLVR-LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGME 243
Query: 583 SLRELRHLKILHVKSN----LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVA 638
SL ++L+++ N L + PS L +L + + ++L LK + ++
Sbjct: 244 SL------ELLYLRRNKLRFLPEFPS-----CSLLKELHVGENQIEMLEAEHLKHLNSIL 292
Query: 639 ELELQNCELERIPHAIFSLSNLQELDLKS----------------------NNIRTI--- 673
L+L++ +L+ +P I L +L+ LDL + N +RTI
Sbjct: 293 VLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRRE 352
Query: 674 ------EEIISFQHLK----------------------------RLTCLKL--WHNKIVT 697
+E++ + K + LK+ + +K T
Sbjct: 353 IISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQAT 412
Query: 698 IPPS--ITHVKN--LESLYFSNNKLESLPVAVFSLQKLRC-LDVSYNNISMIPIEIGLLQ 752
+ P VK+ + S+ FS N+L +P + L+++ +D+S+N +S I +E+ +LQ
Sbjct: 413 LIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQ 472
Query: 753 NLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPE-------------------- 792
L L + N ++ LP+++ ++L+T+NL N LPE
Sbjct: 473 KLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGS 532
Query: 793 ----KVGQLSQLTQLELKGNCLDRLPAQLGQCRMLK 824
K+ + LT L+L+ N L ++P +LG C L+
Sbjct: 533 VDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLR 568
Score = 78.2 bits (191), Expect = 3e-14
Identities = 92/409 (22%), Positives = 188/409 (45%), Gaps = 42/409 (10%)
Query: 473 ELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAF 532
++H L+ +P A+ +L +L L + +P +I+ + NL+ L+L H F
Sbjct: 111 DIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGF 170
Query: 533 SFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN----LNSENNKMIGLE------ 582
L +L L + + +PA L +L L L N L +E N+M L+
Sbjct: 171 EQL-SNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNS 229
Query: 583 --------SLRELRHLKILHVKSN----LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNS 630
L + L++L+++ N L + PS L +L + + ++L
Sbjct: 230 NLLETIPPELAGMESLELLYLRRNKLRFLPEFPS-----CSLLKELHVGENQIEMLEAEH 284
Query: 631 LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKL 690
LK + ++ L+L++ +L+ +P I L +L+ LDL +N+I ++ + HLK L L
Sbjct: 285 LKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLK---FLAL 341
Query: 691 WHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGL 750
N + TI I E L + +K++ + Q + + S + I
Sbjct: 342 EGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPS----QSESATETAMTLPSESRVNIHA 397
Query: 751 LQNLQHLHITGNKVDILPKQLFKCIK---LRTLNLGQNCITSLPEKVGQLSQL-TQLELK 806
+ L+ L + + ++P ++F +K + ++N +N + +P+++ +L ++ + ++L
Sbjct: 398 IITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLS 457
Query: 807 GNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALN-QDINIPF 854
N L + +L C + K + L + ++ ++LP E++ + Q IN+ F
Sbjct: 458 FNKLSFISLEL--CVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSF 504
Score = 60.1 bits (144), Expect = 9e-09
Identities = 85/390 (21%), Positives = 166/390 (42%), Gaps = 63/390 (16%)
Query: 441 VSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVL----- 495
+S N+L+ SL E K +H+ N+ +L +P + + L++L
Sbjct: 204 LSSNELK--SLPAEINRMKRLKHLDCNSN--------LLETIPPELAGMESLELLYLRRN 253
Query: 496 KLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAW 555
KL +PE + L+ELH+ ++ + + + L ++ + +P
Sbjct: 254 KLRFLPE------FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDE 307
Query: 556 VYLLKNLRELYLIGN--------LNSENNKMIGLES--LRELRH----------LKILH- 594
+ LL++L L L N L + + K + LE LR +R LK L
Sbjct: 308 IILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRS 367
Query: 595 -VKSNLTKVPSNITDVAPHLT-------------KLVIHNDGTKLLVLNSL---KKMMNV 637
+K + + T+ A L K++ ++D L+ + + K V
Sbjct: 368 KIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIV 427
Query: 638 AELELQNCELERIPHAIFSLSNL-QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV 696
+ +L IP + L + ++DL N + I + L++LT L L +N +
Sbjct: 428 TSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFIS--LELCVLQKLTFLDLRNNFLN 485
Query: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMI-PIEIGLLQNLQ 755
++P + + L+++ S N+ + LP ++ + L + +S N + + P ++ +++NL
Sbjct: 486 SLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLT 545
Query: 756 HLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
L + N + +P +L C+ LRTL L N
Sbjct: 546 TLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
Score = 39.3 bits (90), Expect = 0.016
Identities = 45/191 (23%), Positives = 81/191 (42%), Gaps = 27/191 (14%)
Query: 482 VPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRC 541
+PD VFD + + I N + LC P ++ + L++ +
Sbjct: 414 IPDEVFDA---------------VKSNIVTSINFSKNQLCEIPKRMVE-----LKEMVSD 453
Query: 542 LHVKFTDVAEIPAWVYLLKNLRELYLIGN-LNSENNKMIGLESLRELRHLKILHVKSNLT 600
+ + F ++ I + +L+ L L L N LNS E + L L+ +++ N
Sbjct: 454 VDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLP------EEMESLVRLQTINLSFNRF 507
Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
K+ + L ++I N+ + +K M N+ L+LQN +L +IP + + NL
Sbjct: 508 KMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNL 567
Query: 661 QELDLKSNNIR 671
+ L L N R
Sbjct: 568 RTLLLDGNPFR 578
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 95.1 bits (235), Expect = 2e-19
Identities = 94/327 (28%), Positives = 142/327 (43%), Gaps = 36/327 (11%)
Query: 515 LQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSE 574
LQ L H P + Q S L H+ + P+ L +LR L+L N +E
Sbjct: 121 LQNNQLRHVPTEALQNLRSLQSLRLDANHISYVP----PSCFSGLHSLRHLWLDDNALTE 176
Query: 575 NNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKK 633
I +++ R L L+ + + N + +P L L +HN+ L
Sbjct: 177 ----IPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDG 232
Query: 634 MMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEII---------------- 677
+ ++ L+L L+ P AI +LSNL+EL SNNIR+I E
Sbjct: 233 LHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNP 292
Query: 678 -------SFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFS-LQ 729
+FQHL L L L +T P +T NLESL + ++ SLP V + L
Sbjct: 293 IQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLP 352
Query: 730 KLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLF-KCIKLRTLNLGQNCIT 788
L+ LD+SYN + +P + Q LQ + + N++ + F + + LR+LNL N I
Sbjct: 353 NLQVLDLSYNLLEDLP-SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIA 411
Query: 789 SL-PEKVGQLSQLTQLELKGNCLDRLP 814
+ P L L +L+L N L P
Sbjct: 412 IIHPNAFSTLPSLIKLDLSSNLLSSFP 438
Score = 49.3 bits (116), Expect = 2e-05
Identities = 70/247 (28%), Positives = 105/247 (42%), Gaps = 52/247 (21%)
Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLREL-YLIGNLNSENNK-------------------M 578
L L + + ++ E P + L NL+EL + N+ S K
Sbjct: 236 LETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQF 295
Query: 579 IGLESLRELRHLKILHVK--SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMN 636
+G + + L L+ L + S +T+ P ++T A +L L + L ++ N
Sbjct: 296 VGRSAFQHLPELRTLTLNGASQITEFP-DLTGTA-NLESLTLTGAQISSLPQTVCNQLPN 353
Query: 637 VAELELQNCELERIPHAIFSL-SNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKI 695
+ L+L LE +P FS+ LQ++DL+ N I I ++ +FQ L L L L NKI
Sbjct: 354 LQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEI-KVDTFQQLLSLRSLNLAWNKI 410
Query: 696 VTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQ 755
I P N +LP SL K LD+S N +S PI L L
Sbjct: 411 AIIHP---------------NAFSTLP----SLIK---LDLSSNLLSSFPIT--GLHGLT 446
Query: 756 HLHITGN 762
HL +TGN
Sbjct: 447 HLKLTGN 453
Score = 39.3 bits (90), Expect = 0.016
Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 3/84 (3%)
Query: 734 LDVSYNNIS-MIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI-KLRTLNLGQNCITSLP 791
LD+S NNIS ++P + L+ L+ L + GN + +PK F + L+ L L N + +P
Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
Query: 792 -EKVGQLSQLTQLELKGNCLDRLP 814
E + L L L L N + +P
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVP 154
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 92.4 bits (228), Expect = 2e-18
Identities = 54/146 (36%), Positives = 83/146 (56%), Gaps = 25/146 (17%)
Query: 698 IPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLR-----------------------CL 734
+PP+I +KNLE L F NN++E LP + SLQKL+ L
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
Query: 735 DVSYNNIS--MIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPE 792
D++YNN+S +P L L+ L+++ N +ILP + K KL+ L+L N + SLP+
Sbjct: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
Query: 793 KVGQLSQLTQLELKGNCLDRLPAQLG 818
++G+L+QL +L ++GN L LP +LG
Sbjct: 122 EIGELTQLKELHIQGNRLTVLPPELG 147
Score = 79.7 bits (195), Expect = 1e-14
Identities = 48/148 (32%), Positives = 81/148 (54%), Gaps = 4/148 (2%)
Query: 626 LVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRL 685
+V ++ ++ N+ L N ++E +P I SL L+ L+L N + T+ F L L
Sbjct: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPR--GFGSLPAL 58
Query: 686 TCLKLWHNKIV--TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
L L +N + ++P + ++ L +LY S+N E LP + L KL+ L + N++
Sbjct: 59 EVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 118
Query: 744 IPIEIGLLQNLQHLHITGNKVDILPKQL 771
+P EIG L L+ LHI GN++ +LP +L
Sbjct: 119 LPKEIGELTQLKELHIQGNRLTVLPPEL 146
Score = 71.6 bits (174), Expect = 3e-12
Identities = 52/158 (32%), Positives = 83/158 (52%), Gaps = 4/158 (2%)
Query: 650 IPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLE 709
+P I L NL+ L+ +N I + IS L++L L L N++ T+P + LE
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQIS--SLQKLKHLNLGMNRLNTLPRGFGSLPALE 59
Query: 710 SLYFSNNKLE--SLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDIL 767
L + N L SLP F L LR L +S N+ ++P +IG L LQ L + N + L
Sbjct: 60 VLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISL 119
Query: 768 PKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLEL 805
PK++ + +L+ L++ N +T LP ++G L Q ++
Sbjct: 120 PKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQV 157
Score = 53.1 bits (126), Expect = 1e-06
Identities = 35/102 (34%), Positives = 54/102 (52%), Gaps = 4/102 (3%)
Query: 743 MIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQ 802
M+P I L+NL+ L+ N+++ LP Q+ KL+ LNLG N + +LP G L L
Sbjct: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
Query: 803 LELKGNCL--DRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEV 842
L+L N L + LP L+ L + D+ F+ LP ++
Sbjct: 61 LDLTYNNLSENSLPGNFFYLTTLR--ALYLSDNDFEILPPDI 100
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 90.9 bits (224), Expect = 5e-18
Identities = 66/205 (32%), Positives = 108/205 (52%), Gaps = 10/205 (4%)
Query: 629 NSLKKMMNVAELE------LQNCELERIPHAIFSLSNLQELD---LKSNNIRTIEEIISF 679
+ L K ++VA LE L L P + LQ L+ +K N++ ++ E ++
Sbjct: 3 SELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLA- 61
Query: 680 QHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYN 739
Q L L L L N IV +P +I + L+ L S+N LE + + L+ LR L ++ N
Sbjct: 62 QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANN 121
Query: 740 NISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQ 799
+ +P E+G L+ LQ L I+ N++ LP++L C+ L+ L + +N + +P + QL
Sbjct: 122 QLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPS 181
Query: 800 LTQLELKGNCLDRLPAQLGQCRMLK 824
L +L + GN L LP LG+ R L+
Sbjct: 182 LNELSMAGNRLAFLPLDLGRSRELQ 206
Score = 79.7 bits (195), Expect = 1e-14
Identities = 53/162 (32%), Positives = 87/162 (53%), Gaps = 3/162 (1%)
Query: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNN 716
L NL EL L SNNI + E I L +L CL L N + + P I ++ L L +NN
Sbjct: 64 LPNLVELYLHSNNIVVVPEAIG--SLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANN 121
Query: 717 KLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIK 776
+L+ LP V L++L+ LD+S N + +P + + +LQ+L + N++ +P+ L +
Sbjct: 122 QLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPS 181
Query: 777 LRTLNLGQNCITSLPEKVGQLSQLTQLELKGNC-LDRLPAQL 817
L L++ N + LP +G+ +L + + N L LP+ L
Sbjct: 182 LNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYL 223
Score = 77.8 bits (190), Expect = 4e-14
Identities = 61/218 (27%), Positives = 105/218 (48%), Gaps = 29/218 (13%)
Query: 571 LNSENNKMIGLESLRE--LRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLV 627
LN N LE L++ L++L+ L++K N LT +P N+ P+L +L +H++ +
Sbjct: 22 LNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV-- 79
Query: 628 LNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTC 687
+P AI SL LQ LDL N + + I L+ L
Sbjct: 80 ----------------------VPEAIGSLVKLQCLDLSDNALEIVCPEIG--RLRALRH 115
Query: 688 LKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIE 747
L+L +N++ +PP + +K L++L S N+L +LP + L+ L V N + +P
Sbjct: 116 LRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRH 175
Query: 748 IGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
+ L +L L + GN++ LP L + +L+ + + N
Sbjct: 176 LCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 90.5 bits (223), Expect = 6e-18
Identities = 77/247 (31%), Positives = 124/247 (50%), Gaps = 7/247 (2%)
Query: 581 LESLRELRH--LKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVA 638
L+ +E +H ++I + +LTK+ +T + L I + K L +SL K+ +
Sbjct: 29 LKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVI-LKIEKEEWKTLP-SSLLKLNQLQ 86
Query: 639 ELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTI 698
E +L L +IP I NL LDL N I I I L RL L L +NKI T+
Sbjct: 87 EWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGL--LTRLQELILSYNKIKTV 144
Query: 699 PPSITHVKNLESLYFSNNK-LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHL 757
P +++ +LE L + N+ + LP + +L KL LD+S N+ + IP+ + + L+ L
Sbjct: 145 PKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWL 204
Query: 758 HITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQL 817
+ NK++ LP + + L TL L +N IT LP+ + + L L L N L +P +
Sbjct: 205 DMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCM 264
Query: 818 GQCRMLK 824
+ L+
Sbjct: 265 EEMANLR 271
Score = 75.5 bits (184), Expect = 2e-13
Identities = 58/216 (26%), Positives = 105/216 (48%), Gaps = 5/216 (2%)
Query: 596 KSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIF 655
K +PS++ + L + +H G L + + + N+ L+L + IP I
Sbjct: 69 KEEWKTLPSSLLKLN-QLQEWQLHRTGL-LKIPEFIGRFQNLIVLDLSRNTISEIPPGIG 126
Query: 656 SLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNK-IVTIPPSITHVKNLESLYFS 714
L+ LQEL L N I+T+ + +S + L L+L N+ I +P ++++ L L S
Sbjct: 127 LLTRLQELILSYNKIKTVPKELS--NCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
Query: 715 NNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKC 774
N ++P+AV ++ L LD+ N + +P I +QNL L + N++ LP+ +
Sbjct: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
Query: 775 IKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCL 810
L TL L N + +P + +++ L + + N L
Sbjct: 245 KNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL 280
Score = 47.0 bits (110), Expect = 8e-05
Identities = 64/277 (23%), Positives = 106/277 (38%), Gaps = 77/277 (27%)
Query: 467 NAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAK 526
N + +LH L +P+ + +L VL L ++IP I +T LQEL L + K
Sbjct: 83 NQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIK 142
Query: 527 VEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRE 586
S + D+ ++P L +L +
Sbjct: 143 TVPKELSNCASLEKLELAVNRDICDLPQ-------------------------ELSNLLK 177
Query: 587 LRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCE 646
L HL + ++ T +P L VLN M + L++ + +
Sbjct: 178 LTHLDL--SMNDFTTIP---------------------LAVLN----MPALEWLDMGSNK 210
Query: 647 LERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVK 706
LE++P I + NL L L+ N I TCL P +I+++K
Sbjct: 211 LEQLPDTIERMQNLHTLWLQRNEI---------------TCL----------PQTISNMK 245
Query: 707 NLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
NL +L SNNKL+ +PV + + LR ++ N + +
Sbjct: 246 NLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKL 282
Score = 35.8 bits (81), Expect = 0.17
Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 11/93 (11%)
Query: 767 LPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKS 826
LP L K +L+ L + + +PE +G+ L L+L N + +P +G L++
Sbjct: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQE- 133
Query: 827 GLVVEDHLFDTLPLEVKE---------ALNQDI 850
L++ + T+P E+ A+N+DI
Sbjct: 134 -LILSYNKIKTVPKELSNCASLEKLELAVNRDI 165
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 90.1 bits (222), Expect = 8e-18
Identities = 57/181 (31%), Positives = 98/181 (54%), Gaps = 2/181 (1%)
Query: 647 LERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVK 706
L +P + L++L LDL N++ T+ + ++ L L L HN + +P ++ +
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEALGALP 171
Query: 707 NLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDI 766
L L ++N+L++LP A+ +L L+ LD+S N + +P EIG L +L L++ N++
Sbjct: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
Query: 767 LPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKS 826
LP L LR L L N + S+P + +L LT+L+L+ N L LP +L ++
Sbjct: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQ 291
Query: 827 G 827
G
Sbjct: 292 G 292
Score = 81.6 bits (200), Expect = 3e-15
Identities = 54/164 (32%), Positives = 83/164 (50%), Gaps = 2/164 (1%)
Query: 682 LKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNI 741
L L L L N + T+P + ++ L +L S+N L LP A+ +L L L V++N +
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
Query: 742 SMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLT 801
+P +G L LQ L ++ N +D LP ++ L LNL N + SLP + L L
Sbjct: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
Query: 802 QLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEA 845
L L N L +PA L + +L + L + D+ LP E+ +A
Sbjct: 244 LLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPPELLDA 285
Score = 81.3 bits (199), Expect = 4e-15
Identities = 49/148 (33%), Positives = 80/148 (54%), Gaps = 2/148 (1%)
Query: 695 IVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNL 754
+ +P ++ + +L L S N LE+LP V ++ L L +S+N +S +P +G L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 755 QHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814
L +T N++ LP L L+ L+L QN + +LP ++G L L +L L N L LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 815 AQLGQCRMLKKSGLVVEDHLFDTLPLEV 842
A L R L+ LV+ +L ++P ++
Sbjct: 234 ASLAGLRSLRL--LVLHSNLLASVPADL 259
Score = 50.1 bits (118), Expect = 9e-06
Identities = 59/250 (23%), Positives = 95/250 (38%), Gaps = 81/250 (32%)
Query: 538 HLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKS 597
HL L + F + +PA V ++ L L L N SE + +G
Sbjct: 126 HLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALG----------------- 168
Query: 598 NLTKVPSNITDVAPHLTKL-VIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 656
P LT L V HN L+ +P A+ +
Sbjct: 169 -----------ALPALTFLTVTHN-------------------------RLQTLPPALGA 192
Query: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNN 716
LS LQ LDL N + T+PP I + +L L ++N
Sbjct: 193 LSTLQRLDLSQN-------------------------LLDTLPPEIGGLGSLLELNLASN 227
Query: 717 KLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKC-- 774
+L+SLP ++ L+ LR L + N ++ +P ++ L L L + N++ LP +L
Sbjct: 228 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPF 287
Query: 775 IKLRTLNLGQ 784
++L+ LG+
Sbjct: 288 VRLQGNPLGE 297
Score = 30.8 bits (68), Expect = 5.6
Identities = 60/228 (26%), Positives = 98/228 (42%), Gaps = 29/228 (12%)
Query: 419 LLHM-VDQYDQLYSKRFGVFLSEVSENKLREISLNH-EWTFEKLRQHISRNAQDKQELHL 476
LLH+ V Q QL F + LS + +L E +L + LR + + Q + L
Sbjct: 50 LLHLCVQQPLQLLQVEF-LRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGA 108
Query: 477 FM---LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCH-CPAKVEQTAF 532
+ L+ +P + L L L L +PA + QM L L L H C +++ +
Sbjct: 109 CLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALG 168
Query: 533 SFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN-----------------LNSEN 575
+ L L V + +P + L L+ L L N LN +
Sbjct: 169 AL--PALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 226
Query: 576 NKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHND 621
N++ L SL LR L++L + SN L VP+++ + P LT+L + ++
Sbjct: 227 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARL-PLLTRLDLRDN 273
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 90.1 bits (222), Expect = 8e-18
Identities = 57/181 (31%), Positives = 98/181 (54%), Gaps = 2/181 (1%)
Query: 647 LERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVK 706
L +P + L++L LDL N++ T+ + ++ L L L HN + +P ++ +
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEALGALP 171
Query: 707 NLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDI 766
L L ++N+L++LP A+ +L L+ LD+S N + +P EIG L +L L++ N++
Sbjct: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
Query: 767 LPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKS 826
LP L LR L L N + S+P + +L LT+L+L+ N L LP +L ++
Sbjct: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQ 291
Query: 827 G 827
G
Sbjct: 292 G 292
Score = 81.6 bits (200), Expect = 3e-15
Identities = 54/164 (32%), Positives = 83/164 (50%), Gaps = 2/164 (1%)
Query: 682 LKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNI 741
L L L L N + T+P + ++ L +L S+N L LP A+ +L L L V++N +
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
Query: 742 SMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLT 801
+P +G L LQ L ++ N +D LP ++ L LNL N + SLP + L L
Sbjct: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
Query: 802 QLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEA 845
L L N L +PA L + +L + L + D+ LP E+ +A
Sbjct: 244 LLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPPELLDA 285
Score = 81.3 bits (199), Expect = 4e-15
Identities = 49/148 (33%), Positives = 80/148 (54%), Gaps = 2/148 (1%)
Query: 695 IVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNL 754
+ +P ++ + +L L S N LE+LP V ++ L L +S+N +S +P +G L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 755 QHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814
L +T N++ LP L L+ L+L QN + +LP ++G L L +L L N L LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 815 AQLGQCRMLKKSGLVVEDHLFDTLPLEV 842
A L R L+ LV+ +L ++P ++
Sbjct: 234 ASLAGLRSLRL--LVLHSNLLASVPADL 259
Score = 50.1 bits (118), Expect = 9e-06
Identities = 59/250 (23%), Positives = 95/250 (38%), Gaps = 81/250 (32%)
Query: 538 HLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKS 597
HL L + F + +PA V ++ L L L N SE + +G
Sbjct: 126 HLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALG----------------- 168
Query: 598 NLTKVPSNITDVAPHLTKL-VIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 656
P LT L V HN L+ +P A+ +
Sbjct: 169 -----------ALPALTFLTVTHN-------------------------RLQTLPPALGA 192
Query: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNN 716
LS LQ LDL N + T+PP I + +L L ++N
Sbjct: 193 LSTLQRLDLSQN-------------------------LLDTLPPEIGGLGSLLELNLASN 227
Query: 717 KLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKC-- 774
+L+SLP ++ L+ LR L + N ++ +P ++ L L L + N++ LP +L
Sbjct: 228 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPF 287
Query: 775 IKLRTLNLGQ 784
++L+ LG+
Sbjct: 288 VRLQGNPLGE 297
Score = 30.8 bits (68), Expect = 5.6
Identities = 60/228 (26%), Positives = 98/228 (42%), Gaps = 29/228 (12%)
Query: 419 LLHM-VDQYDQLYSKRFGVFLSEVSENKLREISLNH-EWTFEKLRQHISRNAQDKQELHL 476
LLH+ V Q QL F + LS + +L E +L + LR + + Q + L
Sbjct: 50 LLHLCVQQPLQLLQVEF-LRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGA 108
Query: 477 FM---LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCH-CPAKVEQTAF 532
+ L+ +P + L L L L +PA + QM L L L H C +++ +
Sbjct: 109 CLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALG 168
Query: 533 SFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN-----------------LNSEN 575
+ L L V + +P + L L+ L L N LN +
Sbjct: 169 AL--PALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 226
Query: 576 NKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHND 621
N++ L SL LR L++L + SN L VP+++ + P LT+L + ++
Sbjct: 227 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARL-PLLTRLDLRDN 273
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 87.8 bits (216), Expect = 4e-17
Identities = 60/175 (34%), Positives = 94/175 (53%), Gaps = 4/175 (2%)
Query: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
L L +L P + + L++ + DL N I + L L L+HN I TIP
Sbjct: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWL--FAPLETLNLYHNCIKTIP 150
Query: 700 PSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHI 759
+I +++ L L S N L +LP +F L L+ L VS N + IP EIG L++L L I
Sbjct: 151 EAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDI 209
Query: 760 TGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814
+ N++ +LP+Q+ K LR LN+ +N + LP+++G L L +L+ N + +P
Sbjct: 210 SCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIP 263
Score = 82.0 bits (201), Expect = 2e-15
Identities = 58/184 (31%), Positives = 98/184 (53%), Gaps = 4/184 (2%)
Query: 634 MMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHN 693
+ + + +L IP ++ + L+ L+L N I+TI E I ++L+ LT L + N
Sbjct: 110 LTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAI--KNLQMLTYLNISRN 167
Query: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
+ T+P + + L+ L SNNKL S+P + L+ L LD+S N I ++P ++G L +
Sbjct: 168 LLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHS 226
Query: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRL 813
L+ L+I N + +LP +L + L L+ N +T +P +L L + L N L
Sbjct: 227 LRELNIRRNNLHVLPDELGD-LPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVP 285
Query: 814 PAQL 817
PAQ+
Sbjct: 286 PAQI 289
Score = 70.1 bits (170), Expect = 8e-12
Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 7/172 (4%)
Query: 688 LKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIE 747
L L K+ P S + + S N+ +P V+ L L++ +N I IP
Sbjct: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
Query: 748 IGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKG 807
I LQ L +L+I+ N + LPK LF + L+ L + N + S+PE++G+L L +L++
Sbjct: 153 IKNLQMLTYLNISRNLLSTLPKYLFD-LPLKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211
Query: 808 NCLDRLPAQLGQCRMLKKSGL------VVEDHLFDTLPLEVKEALNQDINIP 853
N + LP Q+G+ L++ + V+ D L D +++ + N+ IP
Sbjct: 212 NEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIP 263
Score = 54.3 bits (129), Expect = 5e-07
Identities = 48/181 (26%), Positives = 87/181 (48%), Gaps = 8/181 (4%)
Query: 596 KSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIF 655
++ T++PS++ AP T + HN + ++K + + L + L +P +F
Sbjct: 120 RNRFTEIPSDVWLFAPLETLNLYHN--CIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLF 177
Query: 656 SLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSN 715
L L+ L + +N + +I E I LK L L + N+I +P + + +L L
Sbjct: 178 DLP-LKVLVVSNNKLVSIPEEIG--KLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRR 234
Query: 716 NKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 775
N L LP + L ++ LD S N ++ IP+ L +LQ + + N + + P Q+ C+
Sbjct: 235 NNLHVLPDELGDLPLVK-LDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI--CL 291
Query: 776 K 776
K
Sbjct: 292 K 292
Score = 50.8 bits (120), Expect = 5e-06
Identities = 43/178 (24%), Positives = 90/178 (50%), Gaps = 16/178 (8%)
Query: 551 EIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNL-TKVPSNITDV 609
EIP+ V+L L L L N K I E+++ L+ L L++ NL + +P + D+
Sbjct: 125 EIPSDVWLFAPLETLNLYHNCI----KTIP-EAIKNLQMLTYLNISRNLLSTLPKYLFDL 179
Query: 610 APHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNN 669
K+++ ++ + + + K+ ++ EL++ E++ +P + L +L+EL+++ NN
Sbjct: 180 P---LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNN 236
Query: 670 IRTIEEIISFQHLKRL--TCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAV 725
+ + + + L +L +C NK+ IP + +L+ + NN L+ P +
Sbjct: 237 LHVLPDELGDLPLVKLDFSC-----NKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 87.8 bits (216), Expect = 4e-17
Identities = 62/216 (28%), Positives = 110/216 (50%), Gaps = 9/216 (4%)
Query: 630 SLKKMMNVAELELQNCELERIPHAI---FSLSNLQELDLKSNNIRTIEEIISFQHLKRLT 686
+L++ + L L N L+ P + LS++ + DL N + E L L
Sbjct: 37 ALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAAC--QLVSLE 94
Query: 687 CLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPI 746
L L+HN + + P++ ++ L L S N+L LP + L LR L VS N + +P
Sbjct: 95 GLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPP 153
Query: 747 EIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELK 806
+IG L +L+ L ++ N++ LP +L LR LN+ +N +++LPE++G L L +L+
Sbjct: 154 DIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFS 212
Query: 807 GNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEV 842
N + R+P CR+ ++++ + + P +V
Sbjct: 213 CNRVSRIPVSF--CRLRHLQVILLDSNPLQSPPAQV 246
Score = 31.6 bits (70), Expect = 3.3
Identities = 39/146 (26%), Positives = 66/146 (45%), Gaps = 29/146 (19%)
Query: 487 FDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCH-C-----PAKVEQTAFSFL----- 535
+DL+D+ L ++P Q+ +L+ L L H C PA TA ++L
Sbjct: 65 YDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRN 124
Query: 536 ----------RDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN-LNSENNKMIGLESL 584
+ LR L V + +P + L +LR+L + N L S +++ GL SL
Sbjct: 125 QLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSL 184
Query: 585 RELRHLKILHVKSN-LTKVPSNITDV 609
R+ L+V+ N L+ +P + D+
Sbjct: 185 RD------LNVRRNQLSTLPEELGDL 204
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,755,988
Number of Sequences: 37866
Number of extensions: 1350626
Number of successful extensions: 5861
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 165
Number of HSP's that attempted gapping in prelim test: 4033
Number of HSP's gapped (non-prelim): 854
length of query: 858
length of database: 18,247,518
effective HSP length: 111
effective length of query: 747
effective length of database: 14,044,392
effective search space: 10491160824
effective search space used: 10491160824
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.