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Search of human proteins with 33946304
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform D precursor [Homo sapiens]
(921 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ... 1852 0.0
gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ... 1845 0.0
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ... 1840 0.0
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ... 1802 0.0
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),... 1324 0.0
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),... 1315 0.0
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),... 1315 0.0
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ... 1313 0.0
gi|57163987 solute carrier family 8 member 2 [Homo sapiens] 1294 0.0
gi|194354001 solute carrier family 8 (sodium/calcium exchanger),... 603 e-172
gi|33946308 solute carrier family 8 (sodium/calcium exchanger), ... 577 e-164
gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens] 80 7e-15
gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 70 7e-12
gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 70 7e-12
gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 70 7e-12
gi|9966787 solute carrier family 24 (sodium/potassium/calcium ex... 69 2e-11
gi|79749430 FRAS1-related extracellular matrix protein 2 precurs... 65 3e-10
gi|108773804 Fraser syndrome 1 [Homo sapiens] 65 3e-10
gi|31563526 solute carrier family 24 (sodium/potassium/calcium e... 65 4e-10
gi|45504369 solute carrier family 24, member 5 [Homo sapiens] 64 5e-10
gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo sa... 63 1e-09
gi|24111228 solute carrier family 24 member 4 isoform 1 precurso... 63 1e-09
gi|29788985 solute carrier family 24 member 4 isoform 2 precurso... 62 2e-09
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 61 5e-09
gi|54607027 integrin beta 4 isoform 2 precursor [Homo sapiens] 48 5e-05
gi|54607035 integrin beta 4 isoform 1 precursor [Homo sapiens] 48 5e-05
gi|54607033 integrin beta 4 isoform 3 precursor [Homo sapiens] 48 5e-05
gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens] 41 0.004
gi|119120861 formin-like 3 isoform 2 [Homo sapiens] 37 0.11
gi|119120874 formin-like 3 isoform 1 [Homo sapiens] 37 0.11
>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform D precursor [Homo sapiens]
Length = 921
Score = 1852 bits (4797), Expect = 0.0
Identities = 921/921 (100%), Positives = 921/921 (100%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL
Sbjct: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
Query: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
Sbjct: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
Query: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
Sbjct: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
Query: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
Sbjct: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
Query: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
Sbjct: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
Query: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
Sbjct: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
Query: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR
Sbjct: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
Query: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
Sbjct: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
Query: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
Sbjct: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600
VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV
Sbjct: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600
Query: 601 KIVDEEEYERQENFFIALGEPKWMERGISDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKL 660
KIVDEEEYERQENFFIALGEPKWMERGISDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKL
Sbjct: 601 KIVDEEEYERQENFFIALGEPKWMERGISDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKL 660
Query: 661 EVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPS 720
EVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPS
Sbjct: 661 EVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPS 720
Query: 721 CFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLK 780
CFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLK
Sbjct: 721 CFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLK 780
Query: 781 DSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIY 840
DSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIY
Sbjct: 781 DSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIY 840
Query: 841 WALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFV 900
WALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFV
Sbjct: 841 WALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFV 900
Query: 901 SLWLLYILFATLEAYCYIKGF 921
SLWLLYILFATLEAYCYIKGF
Sbjct: 901 SLWLLYILFATLEAYCYIKGF 921
>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform C precursor [Homo sapiens]
Length = 927
Score = 1845 bits (4780), Expect = 0.0
Identities = 921/927 (99%), Positives = 921/927 (99%), Gaps = 6/927 (0%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL
Sbjct: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
Query: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
Sbjct: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
Query: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
Sbjct: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
Query: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
Sbjct: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
Query: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
Sbjct: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
Query: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
Sbjct: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
Query: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR
Sbjct: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
Query: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
Sbjct: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
Query: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
Sbjct: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600
VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV
Sbjct: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600
Query: 601 KIVDEEEYERQENFFIALGEPKWMERGIS------DVTDRKLTMEEEEAKRIAEMGKPVL 654
KIVDEEEYERQENFFIALGEPKWMERGIS DVTDRKLTMEEEEAKRIAEMGKPVL
Sbjct: 601 KIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRKLTMEEEEAKRIAEMGKPVL 660
Query: 655 GEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG 714
GEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG
Sbjct: 661 GEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG 720
Query: 715 EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG 774
EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG
Sbjct: 721 EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG 780
Query: 775 CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAW 834
CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAW
Sbjct: 781 CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAW 840
Query: 835 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLA 894
SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLA
Sbjct: 841 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLA 900
Query: 895 TTWLFVSLWLLYILFATLEAYCYIKGF 921
TTWLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 901 TTWLFVSLWLLYILFATLEAYCYIKGF 927
>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform B precursor [Homo sapiens]
Length = 924
Score = 1840 bits (4766), Expect = 0.0
Identities = 918/924 (99%), Positives = 919/924 (99%), Gaps = 3/924 (0%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL
Sbjct: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
Query: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
Sbjct: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
Query: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
Sbjct: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
Query: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
Sbjct: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
Query: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
Sbjct: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
Query: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
Sbjct: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
Query: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR
Sbjct: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
Query: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
Sbjct: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
Query: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
Sbjct: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600
VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV
Sbjct: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600
Query: 601 KIVDEEEYERQENFFIALGEPKWMERGISDV---TDRKLTMEEEEAKRIAEMGKPVLGEH 657
KIVDEEEYERQENFFIALGEPKWMERGIS + DRKLTMEEEEAKRIAEMGKPVLGEH
Sbjct: 601 KIVDEEEYERQENFFIALGEPKWMERGISALLLSPDRKLTMEEEEAKRIAEMGKPVLGEH 660
Query: 658 PKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEER 717
PKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEER
Sbjct: 661 PKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEER 720
Query: 718 LPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTI 777
LPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTI
Sbjct: 721 LPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTI 780
Query: 778 GLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVA 837
GLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVA
Sbjct: 781 GLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVA 840
Query: 838 AIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTW 897
AIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTW
Sbjct: 841 AIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTW 900
Query: 898 LFVSLWLLYILFATLEAYCYIKGF 921
LFVSLWLLYILFATLEAYCYIKGF
Sbjct: 901 LFVSLWLLYILFATLEAYCYIKGF 924
>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform A precursor [Homo sapiens]
Length = 925
Score = 1802 bits (4668), Expect = 0.0
Identities = 896/925 (96%), Positives = 907/925 (98%), Gaps = 4/925 (0%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL
Sbjct: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
Query: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
Sbjct: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
Query: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
Sbjct: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
Query: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
Sbjct: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
Query: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
Sbjct: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
Query: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
Sbjct: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
Query: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR
Sbjct: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
Query: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
Sbjct: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
Query: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
Sbjct: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600
VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTI +
Sbjct: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHI 600
Query: 601 KIVDEEEYERQENFFIALGEPKWMERGISDV----TDRKLTMEEEEAKRIAEMGKPVLGE 656
K++D+E YE+ +N+FI + P+ ++ DRKLTMEEEEAKRIAEMGKPVLGE
Sbjct: 601 KVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLSPDRKLTMEEEEAKRIAEMGKPVLGE 660
Query: 657 HPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEE 716
HPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEE
Sbjct: 661 HPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEE 720
Query: 717 RLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCT 776
RLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCT
Sbjct: 721 RLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCT 780
Query: 777 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSV 836
IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSV
Sbjct: 781 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSV 840
Query: 837 AAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATT 896
AAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATT
Sbjct: 841 AAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATT 900
Query: 897 WLFVSLWLLYILFATLEAYCYIKGF 921
WLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 901 WLFVSLWLLYILFATLEAYCYIKGF 925
>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform D [Homo sapiens]
Length = 937
Score = 1324 bits (3426), Expect = 0.0
Identities = 674/942 (71%), Positives = 783/942 (83%), Gaps = 29/942 (3%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58
M L L P S H + +LF ++ + AE G+ TG+ C+GS CK+GV
Sbjct: 4 MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59
Query: 59 ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118
ILPIW P++PS GDKIAR VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 60 ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119
Query: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178
GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179
Query: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238
FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT
Sbjct: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239
Query: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295
FFFP+CV+ AWVAD+RLLFYKY++K+YR K RG+IIE EGD P IEMDGK++NSH
Sbjct: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299
Query: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348
FLDG LV LE E D E+RREM RILK+LKQKHP+K+++QL+E+ANY LS QQ
Sbjct: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358
Query: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407
KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+ E D +SK+FF+ +YQC
Sbjct: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418
Query: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467
LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE VG
Sbjct: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478
Query: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527
IIDDDIFEEDE+F V LSNV++ E E+G+ A S A L SP ATVTI DDD
Sbjct: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVST---LACLGSPSTATVTIFDDD 535
Query: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587
HAGIFTFE HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595
Query: 588 EFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERG------ISDVTDRK--LTME 639
EF+NDE VK I ++I D EEYE++ +F + L EPKW+ RG I+D D K LT +
Sbjct: 596 EFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITDEYDDKQPLTSK 655
Query: 640 EEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEA 699
EEE +RIAEMG+P+LGEH KLEVIIEESYEFK+TVDKLIKKTNLALVVGT+SWR+QF+EA
Sbjct: 656 EEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEA 715
Query: 700 ITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILII 759
ITVSA D+D+DE GEE+LPSCFDYVMHFLTVFWKVLFA VPPTEY +GWACF VSIL+I
Sbjct: 716 ITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMI 775
Query: 760 GMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVT 819
G+LTA IGDLASHFGCTIGLKDSVTAVVFVA GTSVPDTFASK AA QD YADASIGNVT
Sbjct: 776 GLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVT 835
Query: 820 GSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRP 879
GSNAVNVFLGIG+AWS+AAIY A G++F VS GTLAFSVTLFTIFAF+ + VLLYRRRP
Sbjct: 836 GSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRP 895
Query: 880 HLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 921
+GGELGGPR KL T+ LFV LWLLYI F++LEAYC+IKGF
Sbjct: 896 EIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 937
>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform C [Homo sapiens]
Length = 960
Score = 1315 bits (3403), Expect = 0.0
Identities = 674/965 (69%), Positives = 783/965 (81%), Gaps = 52/965 (5%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58
M L L P S H + +LF ++ + AE G+ TG+ C+GS CK+GV
Sbjct: 4 MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59
Query: 59 ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118
ILPIW P++PS GDKIAR VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 60 ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119
Query: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178
GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179
Query: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238
FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT
Sbjct: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239
Query: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295
FFFP+CV+ AWVAD+RLLFYKY++K+YR K RG+IIE EGD P IEMDGK++NSH
Sbjct: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299
Query: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348
FLDG LV LE E D E+RREM RILK+LKQKHP+K+++QL+E+ANY LS QQ
Sbjct: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358
Query: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407
KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+ E D +SK+FF+ +YQC
Sbjct: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418
Query: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467
LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE VG
Sbjct: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478
Query: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527
IIDDDIFEEDE+F V LSNV++ E E+G+ A S A L SP ATVTI DDD
Sbjct: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVST---LACLGSPSTATVTIFDDD 535
Query: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587
HAGIFTFE HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595
Query: 588 EFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERG-------------------- 627
EF+NDE VK I ++I D EEYE++ +F + L EPKW+ RG
Sbjct: 596 EFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITGQPVFRKVHARE 655
Query: 628 ---------ISDVTDRK--LTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDK 676
I+D D K LT +EEE +RIAEMG+P+LGEH KLEVIIEESYEFK+TVDK
Sbjct: 656 HPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDK 715
Query: 677 LIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVL 736
LIKKTNLALVVGT+SWR+QF+EAITVSA D+D+DE GEE+LPSCFDYVMHFLTVFWKVL
Sbjct: 716 LIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVL 775
Query: 737 FACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVP 796
FA VPPTEY +GWACF VSIL+IG+LTA IGDLASHFGCTIGLKDSVTAVVFVA GTSVP
Sbjct: 776 FAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVP 835
Query: 797 DTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLA 856
DTFASK AA QD YADASIGNVTGSNAVNVFLGIG+AWS+AAIY A G++F VS GTLA
Sbjct: 836 DTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLA 895
Query: 857 FSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYC 916
FSVTLFTIFAF+ + VLLYRRRP +GGELGGPR KL T+ LFV LWLLYI F++LEAYC
Sbjct: 896 FSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYC 955
Query: 917 YIKGF 921
+IKGF
Sbjct: 956 HIKGF 960
>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform B [Homo sapiens]
Length = 968
Score = 1315 bits (3402), Expect = 0.0
Identities = 674/973 (69%), Positives = 785/973 (80%), Gaps = 60/973 (6%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58
M L L P S H + +LF ++ + AE G+ TG+ C+GS CK+GV
Sbjct: 4 MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59
Query: 59 ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118
ILPIW P++PS GDKIAR VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 60 ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119
Query: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178
GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179
Query: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238
FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT
Sbjct: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239
Query: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295
FFFP+CV+ AWVAD+RLLFYKY++K+YR K RG+IIE EGD P IEMDGK++NSH
Sbjct: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299
Query: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348
FLDG LV LE E D E+RREM RILK+LKQKHP+K+++QL+E+ANY LS QQ
Sbjct: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358
Query: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407
KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+ E D +SK+FF+ +YQC
Sbjct: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418
Query: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467
LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE VG
Sbjct: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478
Query: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527
IIDDDIFEEDE+F V LSNV++ E E+G+ A S A L SP ATVTI DDD
Sbjct: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVS---TLACLGSPSTATVTIFDDD 535
Query: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587
HAGIFTFE HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595
Query: 588 EFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERG-------------------- 627
EF+NDE VKTI VK++D+EEYE+ + FF+ +GEP+ +E
Sbjct: 596 EFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGQPV 655
Query: 628 -----------------ISDVTDRK--LTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESY 668
I+D D K LT +EEE +RIAEMG+P+LGEH KLEVIIEESY
Sbjct: 656 FRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESY 715
Query: 669 EFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHF 728
EFK+TVDKLIKKTNLALVVGT+SWR+QF+EAITVSA D+D+DE GEE+LPSCFDYVMHF
Sbjct: 716 EFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHF 775
Query: 729 LTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVF 788
LTVFWKVLFA VPPTEY +GWACF VSIL+IG+LTA IGDLASHFGCTIGLKDSVTAVVF
Sbjct: 776 LTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVF 835
Query: 789 VAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEF 848
VA GTSVPDTFASK AA QD YADASIGNVTGSNAVNVFLGIG+AWS+AAIY A G++F
Sbjct: 836 VALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQF 895
Query: 849 HVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYIL 908
VS GTLAFSVTLFTIFAF+ + VLLYRRRP +GGELGGPR KL T+ LFV LWLLYI
Sbjct: 896 KVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIF 955
Query: 909 FATLEAYCYIKGF 921
F++LEAYC+IKGF
Sbjct: 956 FSSLEAYCHIKGF 968
>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform A [Homo sapiens]
Length = 973
Score = 1313 bits (3397), Expect = 0.0
Identities = 674/978 (68%), Positives = 785/978 (80%), Gaps = 65/978 (6%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58
M L L P S H + +LF ++ + AE G+ TG+ C+GS CK+GV
Sbjct: 4 MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59
Query: 59 ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118
ILPIW P++PS GDKIAR VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 60 ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119
Query: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178
GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179
Query: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238
FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT
Sbjct: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239
Query: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295
FFFP+CV+ AWVAD+RLLFYKY++K+YR K RG+IIE EGD P IEMDGK++NSH
Sbjct: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299
Query: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348
FLDG LV LE E D E+RREM RILK+LKQKHP+K+++QL+E+ANY LS QQ
Sbjct: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358
Query: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407
KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+ E D +SK+FF+ +YQC
Sbjct: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418
Query: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467
LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE VG
Sbjct: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478
Query: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527
IIDDDIFEEDE+F V LSNV++ E E+G+ A S A L SP ATVTI DDD
Sbjct: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVS---TLACLGSPSTATVTIFDDD 535
Query: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587
HAGIFTFE HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595
Query: 588 EFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERG-------------------- 627
EF+NDE VKTI VK++D+EEYE+ + FF+ +GEP+ +E
Sbjct: 596 EFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYL 655
Query: 628 ----------------------ISDVTDRK--LTMEEEEAKRIAEMGKPVLGEHPKLEVI 663
I+D D K LT +EEE +RIAEMG+P+LGEH KLEVI
Sbjct: 656 FGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVI 715
Query: 664 IEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFD 723
IEESYEFK+TVDKLIKKTNLALVVGT+SWR+QF+EAITVSA D+D+DE GEE+LPSCFD
Sbjct: 716 IEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFD 775
Query: 724 YVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSV 783
YVMHFLTVFWKVLFA VPPTEY +GWACF VSIL+IG+LTA IGDLASHFGCTIGLKDSV
Sbjct: 776 YVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSV 835
Query: 784 TAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWAL 843
TAVVFVA GTSVPDTFASK AA QD YADASIGNVTGSNAVNVFLGIG+AWS+AAIY A
Sbjct: 836 TAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAA 895
Query: 844 QGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLW 903
G++F VS GTLAFSVTLFTIFAF+ + VLLYRRRP +GGELGGPR KL T+ LFV LW
Sbjct: 896 NGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLW 955
Query: 904 LLYILFATLEAYCYIKGF 921
LLYI F++LEAYC+IKGF
Sbjct: 956 LLYIFFSSLEAYCHIKGF 973
>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
Length = 921
Score = 1294 bits (3348), Expect = 0.0
Identities = 635/891 (71%), Positives = 759/891 (85%), Gaps = 29/891 (3%)
Query: 48 CSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITS 107
C GS C+ GV+LP+W P++PSLGDK AR +VYFVA++YMFLGVSIIADRFMA+IEVITS
Sbjct: 43 CQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITS 102
Query: 108 QEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGP 167
+E+E+TI K NGETS T+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AG+LGP
Sbjct: 103 KEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGP 162
Query: 168 STIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPG 227
TIVGSAAFNMF++I +C+YVIP GE+RKIKHLRVFF+TA+WSIFAY+WLY+ILAVFSPG
Sbjct: 163 GTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPG 222
Query: 228 VVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEM 287
VVQVWE LLTL FFPVCV+ AW+ADKRLLFYKY++K+YRTD GIII EGD PK IE+
Sbjct: 223 VVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIEL 282
Query: 288 DGKMMNSHFLDGNL-----VPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYY 342
DG + + G L P E +E+D SRRE+I+ILKDLKQKHP+KDL+QLV +ANYY
Sbjct: 283 DGTFVGAE-APGELGGLGPGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYY 341
Query: 343 ALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDP 402
AL HQQKSRAFYRIQATR+MTGAGN+L++HAA+ +++A+ DE +D S++FF+P
Sbjct: 342 ALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDE-DDGASRIFFEP 400
Query: 403 CSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQK 462
Y CLENCG+VLL+V +GG+ + T YVDY+TEDGSA AG+DYE++EGT+V KPGETQK
Sbjct: 401 SLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQK 460
Query: 463 EFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQ----PEEGMPPAIFNSLPLPRAVLASPCV 518
E +GIIDDDIFEEDEHFFVRL N+R+ + Q P+ G P+ L +P +
Sbjct: 461 ELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGG---------GRPKGRLVAPLL 511
Query: 519 ATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGE 578
ATVTILDDDHAGIF+F+ +HVSE +G ++V+V+R+SGARGTV +P+RTV+GTA+GGG
Sbjct: 512 ATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGV 571
Query: 579 DFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISDVT------ 632
+ED GELEF +DET+KT++VKIVD+EEYE+++NFFI LG+P+W++RGIS +
Sbjct: 572 HYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDG 631
Query: 633 DRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSW 692
DRKLT EEEEA+RIAEMGKPVLGE+ +LEVIIEESY+FK TVDKLIKKTNLALV+GTHSW
Sbjct: 632 DRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSW 691
Query: 693 RDQFMEAITVSAAGDEDEDESG--EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA 750
R+QF+EAITVS AGDE+E+E G EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA
Sbjct: 692 REQFLEAITVS-AGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA 750
Query: 751 CFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVY 810
CF VSIL+IG+LTA+IGDLASHFGCT+GLKDSV AVVFVA GTS+PDTFASK AALQD
Sbjct: 751 CFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQC 810
Query: 811 ADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCI 870
ADASIGNVTGSNAVNVFLG+G+AWSVAA+YWA+QG+ F V GTLAFSVTLFT+FAFV I
Sbjct: 811 ADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGI 870
Query: 871 SVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 921
+VLLYRRRPH+GGELGGPRG KLATT LF+ LWLLYILFA+LEAYC+I+GF
Sbjct: 871 AVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF 921
>gi|194354001 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform G [Homo sapiens]
Length = 298
Score = 603 bits (1556), Expect = e-172
Identities = 298/298 (100%), Positives = 298/298 (100%)
Query: 624 MERGISDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNL 683
MERGISDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNL
Sbjct: 1 MERGISDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNL 60
Query: 684 ALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPT 743
ALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPT
Sbjct: 61 ALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPT 120
Query: 744 EYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKA 803
EYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKA
Sbjct: 121 EYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKA 180
Query: 804 AALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFT 863
AALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFT
Sbjct: 181 AALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFT 240
Query: 864 IFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 921
IFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 241 IFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 298
>gi|33946308 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform F [Homo sapiens]
Length = 284
Score = 577 bits (1487), Expect = e-164
Identities = 284/284 (100%), Positives = 284/284 (100%)
Query: 638 MEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFM 697
MEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFM
Sbjct: 1 MEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFM 60
Query: 698 EAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSIL 757
EAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSIL
Sbjct: 61 EAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSIL 120
Query: 758 IIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGN 817
IIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGN
Sbjct: 121 IIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGN 180
Query: 818 VTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRR 877
VTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRR
Sbjct: 181 VTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRR 240
Query: 878 RPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 921
RPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 241 RPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 284
>gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens]
Length = 6306
Score = 80.5 bits (197), Expect = 7e-15
Identities = 70/282 (24%), Positives = 122/282 (43%), Gaps = 35/282 (12%)
Query: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCL 408
+ ++FY Q T + G ++ ++++ V +D P + F +
Sbjct: 4230 EEKSFYEFQLTAVSEGG-------VLSESSSTANITVVASDSP---YGRFAFSHEQLRVS 4279
Query: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
E V +T++R GD + YKT G+A AG D+ G ++ + GE +K V I
Sbjct: 4280 E-AQRVNITIIRSSGDFGHVR-LWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEI 4337
Query: 469 IDDDIFEEDEHFFVRLSNVR---------IEEEQPEEGMPPAIFNSLPLPRAVLASPCVA 519
+DDD E E F + ++ V I+E + PP I N +
Sbjct: 4338 LDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQIDQPPEIGNI-----------SIV 4386
Query: 520 TVTILDDDHA-GIFTFE--CDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG 576
+ I+ +D+A GI F+ V E +G++ + V+R G G V F + +A G
Sbjct: 4387 RIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQSSSASPG 4446
Query: 577 GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
G D+ + F++ + + I + I+D+ E E +E I L
Sbjct: 4447 GVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILL 4488
Score = 71.6 bits (174), Expect = 3e-12
Identities = 53/190 (27%), Positives = 86/190 (45%), Gaps = 19/190 (10%)
Query: 437 DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
D A DY E +++K + V I+ DD+ E +E F V ++ V +
Sbjct: 3827 DNQATENEDYVLQETIIIMKENIKEAHAEVSILPDDLPELEEGFIVTITEVNLVNSDFST 3886
Query: 497 GMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECD--------TIHVSESIGVM 548
G P S+ P +A + +DD GIF F V + V+
Sbjct: 3887 GQP-----SVRRPGMEIAEIMIEE----NDDPRGIFMFHVTRGAGEVITAYEVPPPLNVL 3937
Query: 549 EVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEY 608
+V V+R +G+ G V V ++ +A G EDF+ ++G LEF + + I + I+D+ E+
Sbjct: 3938 QVPVVRLAGSFGAVNVYWKASPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEF 3995
Query: 609 ERQENFFIAL 618
E E F I+L
Sbjct: 3996 ELTETFNISL 4005
Score = 65.9 bits (159), Expect = 2e-10
Identities = 59/193 (30%), Positives = 86/193 (44%), Gaps = 24/193 (12%)
Query: 438 GSANAGADYE-FTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
G A AG+DYE T +++ G+ +V I+ DD E DE F + L V +
Sbjct: 2495 GQAVAGSDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISASL 2554
Query: 497 GMPPAIFNSLPLPRAVLASPCVATVTI-LDDDHAGIFTFECDTIHVSESIGVMEVK---- 551
P I P ++TV I L+ D G+F + + SE +EV+
Sbjct: 2555 KNQPTI-----------GQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQEQPQ 2603
Query: 552 ------VLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDE 605
+ RT G+ G V V +R V GTA G DF L F ET KT+ + I+D+
Sbjct: 2604 TLVELMIHRTGGSLGQVAVEWRVVGGTAT-EGLDFIGAGEILTFAEGETKKTVILTILDD 2662
Query: 606 EEYERQENFFIAL 618
E E E+ ++L
Sbjct: 2663 SEPEDDESIIVSL 2675
Score = 62.8 bits (151), Expect = 1e-09
Identities = 56/221 (25%), Positives = 91/221 (41%), Gaps = 28/221 (12%)
Query: 414 VLLTVVRKGGDMSKTMYVDYKTED------------GSANAGADYEFTEGTVVLKPGETQ 461
+ L+++R G M K + V Y T D A G DY G + +++
Sbjct: 1997 ITLSIIRLKGLMGKVL-VSYATLDDMEKPPYFPPNLARATQGRDYIPASGFALFGANQSE 2055
Query: 462 KEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATV 521
++ I+DDD E E F+ L N + A S +P + P V T+
Sbjct: 2056 ATIAISILDDDEPERSESVFIELLNSTL----------VAKVQSRSIPNSPRLGPKVETI 2105
Query: 522 T----ILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGG 577
I +DD G + V+E+ + V RT GA V V F+ V TA G
Sbjct: 2106 AQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADVSVKFKAVPITAI-AG 2164
Query: 578 EDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
ED+ ++ ET K + + ++++ E +E+F + L
Sbjct: 2165 EDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQL 2205
Score = 61.2 bits (147), Expect = 4e-09
Identities = 55/227 (24%), Positives = 89/227 (39%), Gaps = 31/227 (13%)
Query: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEF 464
++ E G++ L R + Y ++ A G DY FT + GE K
Sbjct: 2969 FEVNETHGSLTLVAQRSREPLGHVSLFVY-AQNLEAQVGLDYIFTPMILHFADGERYKNV 3027
Query: 465 SVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL 524
++ I+DDDI E DE F + L+N P P L +A + +L
Sbjct: 3028 NIMILDDDIPEGDEKFQLILTN--------------------PSPGLELGKNTIALIIVL 3067
Query: 525 -DDDHAGIFTF---------ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
+DD G+ +F E ++V ES+ V+ + G GTV V F E +
Sbjct: 3068 ANDDGPGVLSFNNSEHFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFIVTEVNSS 3127
Query: 575 GGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
+D + G + + K +++ + + E E E F L P
Sbjct: 3128 NESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3174
Score = 60.5 bits (145), Expect = 7e-09
Identities = 64/226 (28%), Positives = 89/226 (39%), Gaps = 32/226 (14%)
Query: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
+ L + R G + T V ED D+ T + GET + + + DDD+
Sbjct: 51 IRLIIERIGEPANVTAIVSLYGEDAG-----DFFDTYAAAFIPAGETNRTVYIAVCDDDL 105
Query: 474 FEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIF 532
E DE F L+ + P L P TVTIL +D+A GI
Sbjct: 106 PEPDETFIFHLTLQK------------------PSANVKLGWPRTVTVTILSNDNAFGII 147
Query: 533 TFE-CDTIHVSESIG---VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELE 588
+F +I VSE G M + ++R G G V+V F VEG ED G +
Sbjct: 148 SFNMLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFE-VEGGPNPPDEDLSPVKGNIT 206
Query: 589 FKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISDVTDR 634
F + ++D+E E E F I L K +E G T R
Sbjct: 207 FPPGRATVIYNLTVLDDEVPENDEIFLIQL---KSVEGGAEINTSR 249
Score = 58.2 bits (139), Expect = 4e-08
Identities = 57/224 (25%), Positives = 100/224 (44%), Gaps = 20/224 (8%)
Query: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
E G + L V+R G + + +++T +A + DY+ GT+ +PGE K + I
Sbjct: 1734 EEDGEIRLLVIRAQGLLGRVT-AEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINI 1792
Query: 469 IDDDIFEEDEHFFVRLSNV--------RIEEEQPEEGMPPAIFNSLPLPRAVLASPCVAT 520
D+ I E ++ F V L N+ R++ +G F RA L
Sbjct: 1793 TDNSIPELEKSFKVELLNLEGGVAELFRVDGSGSGDG-DMEFFLPTIHKRASLGVASQIL 1851
Query: 521 VTILDDDHA-GIFTFECDTIHVS-----ESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
VTI DHA G+F F +++ VS + + + V+R G V + + ++
Sbjct: 1852 VTIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHW-NIDSDPD 1910
Query: 575 GGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
G D T G + F+ +T I V+I+ +E+ E + F +++
Sbjct: 1911 G---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVSV 1951
Score = 57.8 bits (138), Expect = 5e-08
Identities = 58/221 (26%), Positives = 97/221 (43%), Gaps = 43/221 (19%)
Query: 414 VLLTVVRKGGDMSK-TMYVDYKTE-DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDD 471
V L V+R G +S T++ + ++ DG D FT G + + G+T +V I+ D
Sbjct: 1885 VTLNVIRHHGTLSPVTLHWNIDSDPDG------DLAFTSGNITFEIGQTSANITVEILPD 1938
Query: 472 DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAG 530
+ E D+ F V + L + L + AT+T+L DD G
Sbjct: 1939 EDPELDKAFSVSV---------------------LSVSSGSLGAHINATLTVLASDDPYG 1977
Query: 531 IFTF--ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK-----------GGG 577
IF F + + V E+ + + ++R G G V+V + T++ K G
Sbjct: 1978 IFIFSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQG 2037
Query: 578 EDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
D+ G F +++ TI + I+D++E ER E+ FI L
Sbjct: 2038 RDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIEL 2078
Score = 56.6 bits (135), Expect = 1e-07
Identities = 59/209 (28%), Positives = 92/209 (44%), Gaps = 27/209 (12%)
Query: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
EN ++ V R GG + V +K +A AG DY VVL GET K + +
Sbjct: 2131 ENHVGPIINVTRTGGAFADVS-VKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYV 2189
Query: 469 IDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDH 528
I+D E +E F V+L N E A + L AV+ + DD
Sbjct: 2190 INDIYPELEESFLVQLMN---------ETTGGARLGA--LTEAVI-------IIEASDDP 2231
Query: 529 AGIFTFECDTIHVSE----SIGVMEVKVLRTSGARGTVIVPF-RTVEGTAKGGGEDFEDT 583
G+F F+ + V E S+ V + ++R SG G V V + T+ G G D
Sbjct: 2232 YGLFGFQITKLIVEEPEFNSVKV-NLPIIRNSGTLGNVTVQWVATINGQLATG--DLRVV 2288
Query: 584 YGELEFKNDETVKTIRVKIVDEEEYERQE 612
G + F ET++T+ ++++ ++ E +E
Sbjct: 2289 SGNVTFAPGETIQTLLLEVLADDVPEIEE 2317
Score = 56.6 bits (135), Expect = 1e-07
Identities = 69/295 (23%), Positives = 134/295 (45%), Gaps = 45/295 (15%)
Query: 445 DYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFN 504
++ T G + ++ ++ + ++DDI EE + +L+ V E G+
Sbjct: 4200 EFAETSGKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVS------EGGV------ 4247
Query: 505 SLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTIHVSESIGVMEVKVLRTSGARGTVI 563
+ S A +T++ D G F F + + VSE+ V + ++R+SG G V
Sbjct: 4248 -------LSESSSTANITVVASDSPYGRFAFSHEQLRVSEAQRV-NITIIRSSGDFGHVR 4299
Query: 564 VPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKW 623
+ ++T+ GTA+ G DF GEL F+ E K++ V+I+D++ E E F + + + +
Sbjct: 4300 LWYKTMSGTAEAG-LDFVPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVEL 4358
Query: 624 MERGISDVTDRKLTMEEEEAKRIAEMG--KPVLGEHPKLEVIIEESYEFKTTVDKLIKKT 681
RG D T ++ ++ ++ I + + ++ ++ E IIE ++ K T ++ +
Sbjct: 4359 QGRGY-DFTIQENGLQIDQPPEIGNISIVRIIIMKNDNAEGIIE--FDPKYTAFEVEEDV 4415
Query: 682 NLALVV-----GTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTV 731
L ++ GT+ + V+A D P DY++H TV
Sbjct: 4416 GLIMIPVVRLHGTYGY---------VTA----DFISQSSSASPGGVDYILHGSTV 4457
Score = 56.2 bits (134), Expect = 1e-07
Identities = 65/242 (26%), Positives = 95/242 (39%), Gaps = 32/242 (13%)
Query: 399 FFDPCSYQCLENCGAVLLTVVRKGG--DMSKTMYVDYKTE-DGSANAGADYEFTEGTVVL 455
F C + E + V R G D Y + E DG D+ GT+
Sbjct: 1577 FTGACIPEIAEEGSTISCVVERTRGALDYVHVFYTISQIETDGINYLVDDFANASGTITF 1636
Query: 456 KPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLAS 515
P + + ++ ++DDDI E +E+F V L + P +G S P A +
Sbjct: 1637 LPWQRSEVLNIYVLDDDIPELNEYFRVTLVSA-----IPGDGK----LGSTPTSGASIDP 1687
Query: 516 PCVAT-VTILDDDHA-GIFTFECDT-----------------IHVSESIGVMEVKVLRTS 556
T +TI DH G+ F I V E G + + V+R
Sbjct: 1688 EKETTDITIKASDHPYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQ 1747
Query: 557 GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFI 616
G G V FRTV TA ED+++ G LEF+ E K I + I D E +++F +
Sbjct: 1748 GLLGRVTAEFRTVSLTA-FSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKV 1806
Query: 617 AL 618
L
Sbjct: 1807 EL 1808
Score = 52.4 bits (124), Expect = 2e-06
Identities = 51/210 (24%), Positives = 89/210 (42%), Gaps = 15/210 (7%)
Query: 412 GAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDD 471
GA+ +T G +S + +T A D+ G ++L+ GET ++ I++D
Sbjct: 2856 GAINVTYTTVPGMLS----LKNQTVGNLAEPEVDFVPIIGFLILEEGETAAAINITILED 2911
Query: 472 DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGI 531
D+ E +E+F V L+ V G+ A S P PR + +D G+
Sbjct: 2912 DVPELEEYFLVNLTYV---------GLTMAASTSFP-PRLDSEGLTAQVIIDANDGARGV 2961
Query: 532 FTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKN 591
++ V+E+ G + + R+ G V + F + G D+ T L F +
Sbjct: 2962 IEWQQSRFEVNETHGSLTLVAQRSREPLGHVSL-FVYAQNLEAQVGLDYIFTPMILHFAD 3020
Query: 592 DETVKTIRVKIVDEEEYERQENFFIALGEP 621
E K + + I+D++ E E F + L P
Sbjct: 3021 GERYKNVNIMILDDDIPEGDEKFQLILTNP 3050
Score = 52.0 bits (123), Expect = 3e-06
Identities = 57/205 (27%), Positives = 90/205 (43%), Gaps = 26/205 (12%)
Query: 419 VRKGGDMSKTMYVDYKTEDGSANA-GADYEFTE--GTVVLKPGETQKEFSVGIIDDDIFE 475
V + G + T V Y T+DG A A D+ E T++ + G Q+ S+ + +D I E
Sbjct: 1024 VLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFVNEDGIPE 1083
Query: 476 EDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI-LDDDHAGIFTF 534
DE F++ L N + + G VATV I +DD GIF+
Sbjct: 1084 TDEPFYIILLNSTGDTVVYQYG--------------------VATVIIEANDDPNGIFSL 1123
Query: 535 ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEG-TAKGGGEDFEDTYGELEFKNDE 593
E V E +LR G G+V V ++ + +A G++F +T G + F + E
Sbjct: 1124 EPIDKAVEEG-KTNAFWILRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNFMDGE 1182
Query: 594 TVKTIRVKIVDEEEYERQENFFIAL 618
K I + ++ E E +F+ L
Sbjct: 1183 EAKPIILHAFPDKIPEFNEFYFLKL 1207
Score = 52.0 bits (123), Expect = 3e-06
Identities = 50/208 (24%), Positives = 94/208 (45%), Gaps = 33/208 (15%)
Query: 444 ADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIF 503
+D+ + G ++ +PGE + +V I+DD + E++E F V+L N P+ G I
Sbjct: 3585 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKN-------PKGGAEIGIN 3637
Query: 504 NSLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTIHVS----ESIGVMEVKVLRTSGA 558
+S+ T+TIL +D A GI F ++++ E ++ + V R G
Sbjct: 3638 DSV-------------TITILSNDDAYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGT 3684
Query: 559 RGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
G + T+ A G D T G + F + + TI + I+ + E E + L
Sbjct: 3685 YGRI-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTILADNIPELSEVVIVTL 3739
Query: 619 GEPKWMERGISDVTDRKLTMEEEEAKRI 646
+ G+ D + + T++++ +K +
Sbjct: 3740 --TRITTEGVED-SYKGATIDQDRSKSV 3764
Score = 48.9 bits (115), Expect = 2e-05
Identities = 51/206 (24%), Positives = 90/206 (43%), Gaps = 23/206 (11%)
Query: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
V L + R GG + + V+++ G+A G D+ + GET+K + I+DD
Sbjct: 2606 VELMIHRTGGSLGQVA-VEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSE 2664
Query: 474 FEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFT 533
E+DE V L E G R + +S V + +D+ AGI +
Sbjct: 2665 PEDDESIIVSL-------VYTEGG-----------SRILPSSDTVRVNILANDNVAGIVS 2706
Query: 534 FECDTIHVSESIG-VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKND 592
F+ + V G +++ V+RT RG V V ++ + + +F + G+L F
Sbjct: 2707 FQTASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKIIGQNLE---LNFANFSGQLFFPEG 2763
Query: 593 ETVKTIRVKIVDEEEYERQENFFIAL 618
T+ V ++D+ E +E + + L
Sbjct: 2764 SLNTTLFVHLLDDNIPEEKEVYQVIL 2789
Score = 47.0 bits (110), Expect = 8e-05
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 12/151 (7%)
Query: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTE-GTVVLKPGETQKEFSVG 467
E+ + L V R G S + V Y+T GSA D+E + G + + +T+ +F +
Sbjct: 5018 EDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPLEDFEPVQNGELFFQKFQTEVDFEIT 5077
Query: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILD-D 526
II+D + E +E F++ L++V I Q F+ PR L VA +TILD D
Sbjct: 5078 IINDQLSEIEEFFYINLTSVEIRGLQK--------FDVNWSPRLNL-DFSVAVITILDND 5128
Query: 527 DHAGI-FTFECDTIHVSESIGVMEVKVLRTS 556
D AG+ +F T+ V+ ++ V+ T+
Sbjct: 5129 DLAGMDISFPETTVAVAVDTTLIPVETESTT 5159
Score = 46.2 bits (108), Expect = 1e-04
Identities = 62/254 (24%), Positives = 102/254 (40%), Gaps = 34/254 (13%)
Query: 400 FDP--CSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSAN-AGADYEFTEGTVVLK 456
FDP +++ E+ G +++ VVR G D+ ++ SA+ G DY TV +
Sbjct: 4402 FDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVT-ADFISQSSSASPGGVDYILHGSTVTFQ 4460
Query: 457 PGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASP 516
G+ ++ IIDD+ E +E + L+ AVL
Sbjct: 4461 HGQNLSFINISIIDDNESEFEEPIEILLTGA--------------------TGGAVLGRH 4500
Query: 517 CVATVTILDDDHA-GIFTF---ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGT 572
V+ + I D G+ F +I S ++ + + RT G G + V + TV
Sbjct: 4501 LVSRIIIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEIQVNWETVGPN 4560
Query: 573 AKGG----GEDFEDTYGELEF--KNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMER 626
++ D D L + + + V+TI + I EE E +E F I L K +
Sbjct: 4561 SQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKLHLVKGEAK 4620
Query: 627 GISDVTDRKLTMEE 640
S D LT++E
Sbjct: 4621 LDSRAKDVTLTIQE 4634
Score = 44.7 bits (104), Expect = 4e-04
Identities = 41/138 (29%), Positives = 60/138 (43%), Gaps = 27/138 (19%)
Query: 511 AVLASPCVATVTILDDDHAGIFTFECDTIHVSESI-----GVMEVKVLRTSGARGTVIV- 564
AV P VATVT H G F+ +++ E + EV + RT G G V +
Sbjct: 5200 AVSEKPDVATVTANVSIH-GTFSLGPSIVYIEEEMKNGTFNTAEVLIRRTGGFTGNVSIT 5258
Query: 565 ----------------PFRTVEG----TAKGGGEDFEDTYGELEFKNDETVKTIRVKIVD 604
PFR + G T EDFE+ L F + E + + V+I+D
Sbjct: 5259 VKTFGERCAQMEPNALPFRGIYGISNLTWAVEEEDFEEQTLTLIFLDGERERKVSVQILD 5318
Query: 605 EEEYERQENFFIALGEPK 622
++E E QE F++ L P+
Sbjct: 5319 DDEPEGQEFFYVFLTNPQ 5336
Score = 42.7 bits (99), Expect = 0.002
Identities = 54/222 (24%), Positives = 87/222 (39%), Gaps = 33/222 (14%)
Query: 404 SYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKE 463
+Y+ + + VVR G + V +K SA D++ + G + +
Sbjct: 3927 AYEVPPPLNVLQVPVVRLAGSFG-AVNVYWKASPDSAGL-EDFKPSHGILEFADKQVTAM 3984
Query: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
+ IIDD FE E F + L +V L V TV I
Sbjct: 3985 IEITIIDDAEFELTETFNISLISVA--------------------GGGRLGDDVVVTVVI 4024
Query: 524 LDDDHA-GIFTFECDTIHVSESI------GVMEVKVLRTSGARGTVIVPFRTVEGTAKGG 576
+D G+F FE T+ + ES+ + + V+R+ G +GTV + + T++ AK
Sbjct: 4025 PQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGGKGTVRLEW-TIDEKAK-- 4081
Query: 577 GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
+ G L F E+ KTI + + + E F I L
Sbjct: 4082 -HNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQL 4122
Score = 40.0 bits (92), Expect = 0.010
Identities = 58/256 (22%), Positives = 101/256 (39%), Gaps = 46/256 (17%)
Query: 390 EPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGA--DYE 447
EPEDF ++V + P R G D T+Y K ++ A D
Sbjct: 664 EPEDFAAEVVYIPLH---------------RDGTDGQATVYWSLKPSGFNSKAVTPDDIG 708
Query: 448 FTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLP 507
G+V+ G++ ++ I DDI E +E + L V +E + + G + S
Sbjct: 709 PFNGSVLFLSGQSDTTINITIKGDDIPEMNETVTLSLDRVNVENQVLKSG-----YTSRD 763
Query: 508 LPRAVLASPCVATVTILDDDHAGIFTFECDT-----IHVSESIGVMEVKVLRTSGARGTV 562
L + + +DD G+F F + I ES+ E+ ++R +RG++
Sbjct: 764 L------------IILENDDPGGVFEFSPASRGPYVIKEGESV---ELHIIR---SRGSL 805
Query: 563 IVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPK 622
+ F + E + +T G LEFK E I + + E E++++ L
Sbjct: 806 VKQFLHYRVEPRDSNEFYGNT-GVLEFKPGEREIVITLLARLDGIPELDEHYWVVLSSHG 864
Query: 623 WMERGISDVTDRKLTM 638
E + T +T+
Sbjct: 865 ERESKLGSATIVNITI 880
Score = 39.3 bits (90), Expect = 0.017
Identities = 56/252 (22%), Positives = 91/252 (36%), Gaps = 46/252 (18%)
Query: 389 DEPEDFISKVFFDPCSYQCLENCGAVLLTVVR----KGGDMSKTMY---VDYKTEDGSAN 441
D P F+ ++ P E +++ VVR G + Y + Y G++
Sbjct: 260 DSPVRFLQSIYLVP------EEDHILIIPVVRGKDNNGNLIGSDEYEVSISYAVTTGNST 313
Query: 442 AGADYEFT------EGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPE 495
A A TVV P + I+DD I E E F + L ++ +
Sbjct: 314 AHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKDTLQGD--- 370
Query: 496 EGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIFTFEC----DTIHVSES--IGVM 548
AVL SP V VTI +D G+ +F T+ + E
Sbjct: 371 ---------------AVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDRISRYE 415
Query: 549 EVKVLRTSGARGTVIVPFRTVEGTAKGG--GEDFEDTYGELEFKNDETVKTIRVKIVDEE 606
E+ V+R G G V + + D + G L F + + TI + +VD++
Sbjct: 416 EITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDD 475
Query: 607 EYERQENFFIAL 618
E E + + +
Sbjct: 476 LPEEAEAYLLQI 487
Score = 39.3 bits (90), Expect = 0.017
Identities = 48/187 (25%), Positives = 76/187 (40%), Gaps = 34/187 (18%)
Query: 442 AGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNV----RIEEEQPEEG 497
A +D G + + GET K F + DD+ E +E F ++L +V RI EE
Sbjct: 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEEN---- 1558
Query: 498 MPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTI-HVSESIGVMEVKVLRT 555
A +TI D+A G+F F I ++E + V RT
Sbjct: 1559 -------------------TTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERT 1599
Query: 556 SGARGTVIVPFRTVEGTAKGG----GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQ 611
GA V V F T+ G +DF + G + F + + + + ++D++ E
Sbjct: 1600 RGALDYVHV-FYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELN 1658
Query: 612 ENFFIAL 618
E F + L
Sbjct: 1659 EYFRVTL 1665
Score = 37.4 bits (85), Expect = 0.065
Identities = 31/93 (33%), Positives = 49/93 (52%), Gaps = 5/93 (5%)
Query: 530 GIFTFECDT--IHVSESIGVMEVKVLRTSGARGTVI-VPFRTVEGTAKGGGEDFEDTY-G 585
G+F F + I VSE ++ + V R G +I V ++T G+AK EDFE G
Sbjct: 5003 GVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPL-EDFEPVQNG 5061
Query: 586 ELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
EL F+ +T + I++++ E +E F+I L
Sbjct: 5062 ELFFQKFQTEVDFEITIINDQLSEIEEFFYINL 5094
Score = 35.8 bits (81), Expect = 0.19
Identities = 21/57 (36%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 445 DYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSN----VRIEEEQPEEG 497
D+E T++ GE +++ SV I+DDD E E F+V L+N +I EE+ + G
Sbjct: 5293 DFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQIVEEKDDTG 5349
Score = 35.4 bits (80), Expect = 0.25
Identities = 52/233 (22%), Positives = 94/233 (40%), Gaps = 31/233 (13%)
Query: 391 PEDFISKVFFDPCSYQCLENCGAVLLT--VVRKGGDMSKTMYVDYKTEDGSANAGADYEF 448
PE K + +P + + G +L+T V R G + M Y + D+
Sbjct: 4646 PETLSKKTYSEPLALE-----GPLLITFFVRRVKGTFGEIMV--YWELSSEFDITEDFLS 4698
Query: 449 TEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPL 508
T G + GE++ F V ++ D++ E +E + ++L +V E L L
Sbjct: 4699 TSGFFTIADGESEASFDVHLLPDEVPEIEEDYVIQLVSVEGGAE-------------LDL 4745
Query: 509 PRAVLASPCVATVTILDDDHAGIFTFECD--TIHVSES-IGVMEVKVLRTSGARGTVIVP 565
+++ A +DD G+F D +I + ++ I +++ + R +G G V V
Sbjct: 4746 EKSITWFSVYA-----NDDPHGVFALYSDRQSILIGQNLIRSIQINITRLAGTFGDVAVG 4800
Query: 566 FRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
R + K E+ +L K+ T K V I ++ NF + L
Sbjct: 4801 LR-ISSDHKEQPIVTENAERQLVVKDGATYKVDVVPIKNQVFLSLGSNFTLQL 4852
Score = 32.3 bits (72), Expect = 2.1
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 12/97 (12%)
Query: 401 DPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGET 460
DP SY V LTVVR G T+ +++ ++ A + GT+ E+
Sbjct: 4051 DPDSY--------VTLTVVRSPGGKG-TVRLEWTIDE---KAKHNLSPLNGTLHFDETES 4098
Query: 461 QKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEG 497
QK + + D + EED F ++L ++ E P +G
Sbjct: 4099 QKTIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKG 4135
Score = 32.0 bits (71), Expect = 2.7
Identities = 21/77 (27%), Positives = 34/77 (44%), Gaps = 1/77 (1%)
Query: 410 NCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGII 469
N V L ++R G + T +G G D G V PGET + + ++
Sbjct: 2250 NSVKVNLPIIRNSGTLGNVTVQWVATINGQLATG-DLRVVSGNVTFAPGETIQTLLLEVL 2308
Query: 470 DDDIFEEDEHFFVRLSN 486
DD+ E +E V+L++
Sbjct: 2309 ADDVPEIEEVIQVQLTD 2325
>gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 70.5 bits (171), Expect = 7e-12
Identities = 64/229 (27%), Positives = 105/229 (45%), Gaps = 34/229 (14%)
Query: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Y ++ L + + G + +T ++ T+D +A D+++ T + PG+T
Sbjct: 1781 YYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTAT 1840
Query: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
+ V II D+ +E E F + LS PL AVL P +ATV I
Sbjct: 1841 WRVRIIPDNEYETSETFQIILSE--------------------PL-MAVLEFPEMATVEI 1879
Query: 524 LDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG------ 576
+D D + ++ E + + E IG + + V R+ A +IV T +G+A G
Sbjct: 1880 VDPGDESTVYIPEAE-YKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL 1938
Query: 577 GEDF----EDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
D+ ED L F +ET KT +V I+D+ YE +E+F ++L P
Sbjct: 1939 FSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
Score = 36.6 bits (83), Expect = 0.11
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 3/75 (4%)
Query: 400 FDPCSYQCLENCGAVLLTVVRKGGDMSKTMYV---DYKTEDGSANAGADYEFTEGTVVLK 456
F Y E+ V + V R+G D+S+ + K+E SA AG DY +
Sbjct: 2015 FGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFA 2074
Query: 457 PGETQKEFSVGIIDD 471
PG + F V I+DD
Sbjct: 2075 PGVRMQTFQVTILDD 2089
>gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 70.5 bits (171), Expect = 7e-12
Identities = 64/229 (27%), Positives = 105/229 (45%), Gaps = 34/229 (14%)
Query: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Y ++ L + + G + +T ++ T+D +A D+++ T + PG+T
Sbjct: 1781 YYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTAT 1840
Query: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
+ V II D+ +E E F + LS PL AVL P +ATV I
Sbjct: 1841 WRVRIIPDNEYETSETFQIILSE--------------------PL-MAVLEFPEMATVEI 1879
Query: 524 LDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG------ 576
+D D + ++ E + + E IG + + V R+ A +IV T +G+A G
Sbjct: 1880 VDPGDESTVYIPEAE-YKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL 1938
Query: 577 GEDF----EDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
D+ ED L F +ET KT +V I+D+ YE +E+F ++L P
Sbjct: 1939 FSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
Score = 36.6 bits (83), Expect = 0.11
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 3/75 (4%)
Query: 400 FDPCSYQCLENCGAVLLTVVRKGGDMSKTMYV---DYKTEDGSANAGADYEFTEGTVVLK 456
F Y E+ V + V R+G D+S+ + K+E SA AG DY +
Sbjct: 2015 FGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFA 2074
Query: 457 PGETQKEFSVGIIDD 471
PG + F V I+DD
Sbjct: 2075 PGVRMQTFQVTILDD 2089
>gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 70.5 bits (171), Expect = 7e-12
Identities = 64/229 (27%), Positives = 105/229 (45%), Gaps = 34/229 (14%)
Query: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Y ++ L + + G + +T ++ T+D +A D+++ T + PG+T
Sbjct: 1781 YYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTAT 1840
Query: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
+ V II D+ +E E F + LS PL AVL P +ATV I
Sbjct: 1841 WRVRIIPDNEYETSETFQIILSE--------------------PL-MAVLEFPEMATVEI 1879
Query: 524 LDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG------ 576
+D D + ++ E + + E IG + + V R+ A +IV T +G+A G
Sbjct: 1880 VDPGDESTVYIPEAE-YKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL 1938
Query: 577 GEDF----EDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
D+ ED L F +ET KT +V I+D+ YE +E+F ++L P
Sbjct: 1939 FSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
Score = 36.6 bits (83), Expect = 0.11
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 3/75 (4%)
Query: 400 FDPCSYQCLENCGAVLLTVVRKGGDMSKTMYV---DYKTEDGSANAGADYEFTEGTVVLK 456
F Y E+ V + V R+G D+S+ + K+E SA AG DY +
Sbjct: 2015 FGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFA 2074
Query: 457 PGETQKEFSVGIIDD 471
PG + F V I+DD
Sbjct: 2075 PGVRMQTFQVTILDD 2089
>gi|9966787 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 2 [Homo sapiens]
Length = 661
Score = 68.9 bits (167), Expect = 2e-11
Identities = 50/168 (29%), Positives = 81/168 (48%), Gaps = 38/168 (22%)
Query: 77 VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
+I++ + +IYMF+ ++I+ D F + +++ ++ + V+
Sbjct: 135 IILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGIS-----------------DDVAGA 177
Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
T MA G SAPE+ SLI V FIA ++G TIVGSA FN+ +IG+C +R
Sbjct: 178 TFMAAGGSAPELFTSLIGV----FIAHSNVGIGTIVGSAVFNILFVIGMCALF-----SR 228
Query: 196 KIKHLRVFFITAAWSIFAYIWLY-----MILAVFSPGVVQVWEGLLTL 238
+I +L W +F + Y M++ F V+ WE LL L
Sbjct: 229 EILNL------TWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLL 270
Score = 53.9 bits (128), Expect = 7e-07
Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 8/178 (4%)
Query: 707 DEDEDESGEERLPSCFDYVMHFLTVF------WKVLFACVPPTEYCHGWACFAVSILIIG 760
DE+ED+ PS + FL VF W L P+ F SI I
Sbjct: 452 DEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIA 511
Query: 761 MLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTG 820
+ + ++ A G TIG+ + + + +A GTS+PD S A + + D ++ + G
Sbjct: 512 VFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGL-GDMAVSSSVG 570
Query: 821 SNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRR 878
SN ++ +G+ L W + + Q S G V LF + FV +S+ L + R
Sbjct: 571 SNIFDITVGLPLPWLLYTVIHRFQPVAVS-SNGLFCAIVLLFIMLLFVILSIALCKWR 627
Score = 35.0 bits (79), Expect = 0.32
Identities = 17/56 (30%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Query: 777 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL 832
+G+ D V F+A G S P+ F S +++ IG + GS N+ IG+
Sbjct: 168 LGISDDVAGATFMAAGGSAPELFTSLIGVF-IAHSNVGIGTIVGSAVFNILFVIGM 222
Score = 32.0 bits (71), Expect = 2.7
Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 3/51 (5%)
Query: 130 NETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
+E + LT++A G+S P+++ S+I V G GD+ S+ VGS F++ +
Sbjct: 531 SEEIMGLTILAAGTSIPDLITSVI-VARKGL--GDMAVSSSVGSNIFDITV 578
>gi|79749430 FRAS1-related extracellular matrix protein 2 precursor
[Homo sapiens]
Length = 3169
Score = 65.1 bits (157), Expect = 3e-10
Identities = 58/229 (25%), Positives = 92/229 (40%), Gaps = 33/229 (14%)
Query: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Y + L V+++ G + +T ++ T D +A D++ + V PG+T+
Sbjct: 1777 YYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRAT 1836
Query: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
+ V I+ D E+ E F V LS P + A L P VATV I
Sbjct: 1837 WRVRILSDGEHEQSETFQVVLSE-------------PVL--------AALEFPTVATVEI 1875
Query: 524 LDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKG-------G 576
+D V E +G + + + R+ ++V T +GTA G
Sbjct: 1876 VDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLS 1935
Query: 577 GEDF----EDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
D+ ED + F DE K R+ I+D+ YE +E F + L P
Sbjct: 1936 YSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMP 1984
Score = 61.2 bits (147), Expect = 4e-09
Identities = 70/287 (24%), Positives = 119/287 (41%), Gaps = 35/287 (12%)
Query: 375 EQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYK 434
E +K S+++ +D P K+ F Y E+ G ++ T++ + GD+ V
Sbjct: 2112 EPSKATVSINDSVSDLP-----KMQFKERIYTGSESDGQIV-TMIHRTGDVQYRSSVRCY 2165
Query: 435 TEDGSANAGADYEFTEGT----VVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIE 490
T GSA D+E T + PGET+K + ++DD ++EE E +R+
Sbjct: 2166 TRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEE-------LRLV 2218
Query: 491 EEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSE-----SI 545
P+ P A + + I DD + F V+E
Sbjct: 2219 LGTPQSNSPFG---------AAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGES 2269
Query: 546 GVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDE 605
V+ + V+R IV T +G+A G ED+ E+EFK ET + +++ +
Sbjct: 2270 VVIRIPVIRQGDTSKVSIVRVHTKDGSATSG-EDYHPVSEEIEFKEGETQHVVEIEVTFD 2328
Query: 606 EEYERQENFFIALGEPKWMERGISDVTDRKLTMEEEEAKRIAEMGKP 652
E +E F + L K E I+++ K + EE +A++ P
Sbjct: 2329 GVREMREAFTVHL---KPDENMIAEMQLTKAIVYIEEMSSMADVTFP 2372
Score = 57.8 bits (138), Expect = 5e-08
Identities = 73/269 (27%), Positives = 109/269 (40%), Gaps = 53/269 (19%)
Query: 389 DEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSAN------- 441
DEP VF Y E+ G + + + R+ GD+S+ + V T+ G+A
Sbjct: 1880 DEPT-----VFIPQSKYSVEEDVGELFIPI-RRSGDVSQELMVVCYTQQGTATGTVPTSV 1933
Query: 442 -AGADY----EFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
+ +DY E V E +K + IIDD ++EE+E F V L
Sbjct: 1934 LSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLL------------ 1981
Query: 497 GMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAGIFTFECDTIHVSESIGVMEVKVLRT 555
S+P+ + + A VTI+ D D IF F V ES G +EV+V RT
Sbjct: 1982 --------SMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRT 2033
Query: 556 S---GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVD---EEEYE 609
+V V R + + G D+ L+F ++ +RV I+D + E
Sbjct: 2034 GTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALE 2093
Query: 610 RQENFFI--------ALGEPKWMERGISD 630
E F + ALGEP I+D
Sbjct: 2094 GIEKFELVLRMPMNAALGEPSKATVSIND 2122
Score = 48.9 bits (115), Expect = 2e-05
Identities = 63/232 (27%), Positives = 95/232 (40%), Gaps = 27/232 (11%)
Query: 399 FFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDY---KTEDGSANAGADYEFTEGTVVL 455
+F Y E+ G V + V R G D+SK+ V KT+ SA+AG DY +
Sbjct: 2011 YFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDF 2070
Query: 456 KPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLAS 515
PG + V I+DD L +E + E + +P+ A L
Sbjct: 2071 APGVNMQPVRVVILDD------------LGQPALEGIEKFE-----LVLRMPM-NAALGE 2112
Query: 516 PCVATVTILDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
P ATV+I D F+ SES G + + RT + V T +G+A+
Sbjct: 2113 PSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQ 2172
Query: 575 GGGEDFEDTYGE----LEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPK 622
DFE+ + F ET K ++++D+ YE E + LG P+
Sbjct: 2173 -VMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQ 2223
Score = 35.4 bits (80), Expect = 0.25
Identities = 23/89 (25%), Positives = 43/89 (48%)
Query: 533 TFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKND 592
+FE + V+E ++V + R T + T + TA+ + +++F
Sbjct: 1772 SFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPG 1831
Query: 593 ETVKTIRVKIVDEEEYERQENFFIALGEP 621
+T T RV+I+ + E+E+ E F + L EP
Sbjct: 1832 QTRATWRVRILSDGEHEQSETFQVVLSEP 1860
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 65.1 bits (157), Expect = 3e-10
Identities = 65/239 (27%), Positives = 104/239 (43%), Gaps = 26/239 (10%)
Query: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGT----VVLKPGETQKEFSVGII 469
VL + + GD+S V T+ SA D+E + + G+ K +V I
Sbjct: 2935 VLHVPITRSGDLSYESSVRCYTQSHSAQVMEDFEERQNADSSRITFLKGDKVKNCTVYIH 2994
Query: 470 DDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA 529
DD +FE +E F V L G+P S A + +AT+TI +D+ A
Sbjct: 2995 DDSMFEPEEQFRVYL------------GLPLGNHWS----GARIGKNNMATITISNDEDA 3038
Query: 530 GIFTFECDTIHVSE-----SIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTY 584
FE V E +I ++ +KV+R T V T +G+A+ G D+
Sbjct: 3039 PTIEFEEAAYQVREPAGPDAIAILNIKVIRRGDQNRTSKVRCSTRDGSAQSG-VDYYPKS 3097
Query: 585 GELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISDVTDRKLTMEEEEA 643
L+F +V+I+ E+ E E+F + LG +E + DVT +T+ ++EA
Sbjct: 3098 RVLKFSPGVDHIFFKVEILSNEDREWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEA 3156
Score = 64.7 bits (156), Expect = 4e-10
Identities = 69/245 (28%), Positives = 99/245 (40%), Gaps = 42/245 (17%)
Query: 396 SKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGA---------DY 446
S + F SY E G+V +TV R G ++++ V +TE G+A++ + DY
Sbjct: 2552 SLISFKYTSYNVSEKAGSVSVTVQRTG-NLNQYAIVLCRTEQGTASSSSRVSSQPGQQDY 2610
Query: 447 EFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSL 506
G V E K ++ I DDD+FE E F V LS MP
Sbjct: 2611 VEYAGQVQFDEREDTKSCTIVINDDDVFENVESFTVELS------------MP------- 2651
Query: 507 PLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPF 566
A+L A V I D + F+ V+ES G + + R A V
Sbjct: 2652 --AYALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPIERKGDASSIVSAIC 2709
Query: 567 RTVEGTAKG-------GGEDFE----DTYGELEFKNDETVKTIRVKIVDEEEYERQENFF 615
TV +A G G DF+ + F T+ T V ++D+ EYE +E F
Sbjct: 2710 YTVPKSAMGSSLYALESGSDFKSRGMSAASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFE 2769
Query: 616 IALGE 620
IAL +
Sbjct: 2770 IALAD 2774
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/131 (26%), Positives = 62/131 (47%), Gaps = 10/131 (7%)
Query: 531 IFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKG--------GGEDFED 582
+ +F+ + +VSE G + V V RT IV RT +GTA G +D+ +
Sbjct: 2553 LISFKYTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTASSSSRVSSQPGQQDYVE 2612
Query: 583 TYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISDVTDRKLTMEEEE 642
G+++F E K+ + I D++ +E E+F + L P + G + T K+ + + E
Sbjct: 2613 YAGQVQFDEREDTKSCTIVINDDDVFENVESFTVELSMPAYALLG--EFTQAKVIINDTE 2670
Query: 643 AKRIAEMGKPV 653
+ E K +
Sbjct: 2671 DEPTLEFDKKI 2681
Score = 50.1 bits (118), Expect = 1e-05
Identities = 46/154 (29%), Positives = 65/154 (42%), Gaps = 24/154 (15%)
Query: 381 SSMSEVHTDEPEDFISKVFFDPCSYQCLENCG----AVLLTVVRKGGDMSKTMYVDYKTE 436
++M+ + ED + F+ +YQ E G A+L V + GD ++T V T
Sbjct: 3025 NNMATITISNDED-APTIEFEEAAYQVREPAGPDAIAILNIKVIRRGDQNRTSKVRCSTR 3083
Query: 437 DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
DGSA +G DY + PG F V I+ ++ E E F + L + P E
Sbjct: 3084 DGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDREWHESFSLVLG-----PDDPVE 3138
Query: 497 GMPPAIFNSLPLPRAVLASPCVATVTILDDDHAG 530
AVL ATVTILD + AG
Sbjct: 3139 --------------AVLGDVTTATVTILDQEAAG 3158
Score = 49.7 bits (117), Expect = 1e-05
Identities = 62/237 (26%), Positives = 92/237 (38%), Gaps = 33/237 (13%)
Query: 396 SKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKT---EDGSANAGADYEFTEGT 452
S V ++ E+ G V + V+R G D+S V T + SA G DY +
Sbjct: 2798 STVSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYVPSSRK 2857
Query: 453 VVLKPGETQKEFSVGIIDD---DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLP 509
V PG ++ ++ I+DD + E E F V LS+ +
Sbjct: 2858 VEFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFLSSAQ--------------------- 2896
Query: 510 RAVLASPCVATVTILDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRT 568
A L P A + I D F D + V E GV+ V + R+ V T
Sbjct: 2897 GAELTKPFQAVIAINDTFQDVPSMQFAKDLLLVKEKEGVLHVPITRSGDLSYESSVRCYT 2956
Query: 569 VEGTAKGGGEDFEDTY----GELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
+A+ EDFE+ + F + VK V I D+ +E +E F + LG P
Sbjct: 2957 QSHSAQ-VMEDFEERQNADSSRITFLKGDKVKNCTVYIHDDSMFEPEEQFRVYLGLP 3012
>gi|31563526 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 3 [Homo sapiens]
Length = 644
Score = 64.7 bits (156), Expect = 4e-10
Identities = 53/176 (30%), Positives = 83/176 (47%), Gaps = 14/176 (7%)
Query: 707 DEDEDESGEERLPSCFDYVMHFL-TVFWK-------VLFACVP----PTEYCHGWACFAV 754
+E+EDE +E + FD L TV W VL+ VP P FA
Sbjct: 423 EEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFAS 482
Query: 755 SILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADAS 814
S L I + ++ + + G T+G+ D + + F+A GTSVPD AS A Q + D +
Sbjct: 483 STLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GDMA 541
Query: 815 IGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCI 870
+ N GSN ++ +G+GL W++ + G +++ L +SV L FV +
Sbjct: 542 VSNSIGSNVFDILIGLGLPWALQTLA-VDYGSYIRLNSRGLIYSVGLLLASVFVTV 596
Score = 60.5 bits (145), Expect = 7e-09
Identities = 41/110 (37%), Positives = 58/110 (52%), Gaps = 22/110 (20%)
Query: 77 VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
V+++ + IYMF ++I+ D F P+ E + + +E V+
Sbjct: 110 VVLHVLCAIYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGA 152
Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGIC 185
T MA GSSAPE+ S+I V FI GD+G TIVGSA FN+ IIG+C
Sbjct: 153 TFMAAGSSAPELFTSVIGV----FITKGDVGVGTIVGSAVFNILCIIGVC 198
Score = 33.1 bits (74), Expect = 1.2
Identities = 22/89 (24%), Positives = 36/89 (40%), Gaps = 6/89 (6%)
Query: 779 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL-----A 833
L + V F+A G+S P+ F S + D +G + GS N+ IG+
Sbjct: 145 LSEDVAGATFMAAGSSAPELFTS-VIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAG 203
Query: 834 WSVAAIYWALQGQEFHVSAGTLAFSVTLF 862
VA W L + + +A V ++
Sbjct: 204 QVVALSSWCLLRDSIYYTLSVIALIVFIY 232
Score = 33.1 bits (74), Expect = 1.2
Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ I +G+
Sbjct: 509 DVIMGITFLAAGTSVPDCMASLI-VARQGM--GDMAVSNSIGSNVFDILIGLGL 559
>gi|45504369 solute carrier family 24, member 5 [Homo sapiens]
Length = 500
Score = 64.3 bits (155), Expect = 5e-10
Identities = 52/174 (29%), Positives = 87/174 (50%), Gaps = 32/174 (18%)
Query: 77 VIVYFVALIYMFLGVSIIADR-FMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
+I+YF+ ++YMF+ +SI+ D F+ S+E+I+ ++ V+
Sbjct: 69 IIIYFLIIVYMFMAISIVCDEYFLPSLEIISES------------------LGLSQDVAG 110
Query: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYV-IPDGE 193
T MA GSSAPE++ + + V FI GD+G STI+GSA +N ++GIC +
Sbjct: 111 TTFMAAGSSAPELVTAFLGV----FITKGDIGISTILGSAIYN---LLGICAACGLLSNT 163
Query: 194 TRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLL 247
+ +F AA++I A +L + V +EG L L + + VL+
Sbjct: 164 VSTLSCWPLFRDCAAYTISA----AAVLGIIYDNQVYWYEGALLLLIYGLYVLV 213
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 13/109 (11%)
Query: 732 FWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAF 791
FWK F F +S + I T I+ + + G T+ + D+V + +A
Sbjct: 329 FWKNYFVIT-----------FFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA 377
Query: 792 GTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIY 840
GTS+PDT AS A + D ++ N+ GSN ++ L +G+ W + +
Sbjct: 378 GTSIPDTIASVLVARKG-KGDMAMSNIVGSNVFDM-LCLGIPWFIKTAF 424
Score = 35.4 bits (80), Expect = 0.25
Identities = 21/51 (41%), Positives = 31/51 (60%), Gaps = 3/51 (5%)
Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFII 181
+TV LTL+A G+S P+ + S++ V G GD+ S IVGS F+M +
Sbjct: 367 DTVMGLTLLAAGTSIPDTIASVL-VARKG--KGDMAMSNIVGSNVFDMLCL 414
>gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo
sapiens]
Length = 558
Score = 62.8 bits (151), Expect = 1e-09
Identities = 64/261 (24%), Positives = 115/261 (44%), Gaps = 49/261 (18%)
Query: 77 VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
V+++ + +YMF ++I+ D F P+ E + + +E V+
Sbjct: 36 VLLHILGALYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGA 78
Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
T MA GSS PE+ S+I V FI GD+G TIVGSA FN+ IIG+C G+
Sbjct: 79 TFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVV 132
Query: 196 KIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRL 255
++ ++ S++ I + +++ + WEGL+ + + +L +
Sbjct: 133 RL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYIL--------I 180
Query: 256 LFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNL----VPLEG--KEV 309
+ Y + + T K + I +P E++ + F DG+ VPL G KE
Sbjct: 181 MKYNVKMQAFFTVKQKSI----ANGNPVNSELEA---GNDFYDGSYDDPSVPLLGQVKEK 233
Query: 310 DESRREMIRILKDLKQKHPEK 330
+ + + ++ ++ P K
Sbjct: 234 PQYGKNPVVMVDEIMSSSPPK 254
Score = 60.5 bits (145), Expect = 7e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 752 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 811
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 451
Query: 812 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 871
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 508
Query: 872 VL 873
VL
Sbjct: 509 VL 510
Score = 35.4 bits (80), Expect = 0.25
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 779 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 834
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 71 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 129
Query: 835 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 868
V + W + V ++ +++++ + F+
Sbjct: 130 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 157
Score = 33.5 bits (75), Expect = 0.93
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ + +G+
Sbjct: 422 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 472
>gi|24111228 solute carrier family 24 member 4 isoform 1 precursor
[Homo sapiens]
Length = 605
Score = 62.8 bits (151), Expect = 1e-09
Identities = 64/261 (24%), Positives = 115/261 (44%), Gaps = 49/261 (18%)
Query: 77 VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
V+++ + +YMF ++I+ D F P+ E + + +E V+
Sbjct: 83 VLLHILGALYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGA 125
Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
T MA GSS PE+ S+I V FI GD+G TIVGSA FN+ IIG+C G+
Sbjct: 126 TFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVV 179
Query: 196 KIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRL 255
++ ++ S++ I + +++ + WEGL+ + + +L +
Sbjct: 180 RL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYIL--------I 227
Query: 256 LFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNL----VPLEG--KEV 309
+ Y + + T K + I +P E++ + F DG+ VPL G KE
Sbjct: 228 MKYNVKMQAFFTVKQKSI----ANGNPVNSELEA---GNDFYDGSYDDPSVPLLGQVKEK 280
Query: 310 DESRREMIRILKDLKQKHPEK 330
+ + + ++ ++ P K
Sbjct: 281 PQYGKNPVVMVDEIMSSSPPK 301
Score = 60.5 bits (145), Expect = 7e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 752 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 811
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 498
Query: 812 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 871
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 555
Query: 872 VL 873
VL
Sbjct: 556 VL 557
Score = 35.4 bits (80), Expect = 0.25
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 779 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 834
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
Query: 835 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 868
V + W + V ++ +++++ + F+
Sbjct: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
Score = 33.5 bits (75), Expect = 0.93
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ + +G+
Sbjct: 469 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 519
>gi|29788985 solute carrier family 24 member 4 isoform 2 precursor
[Homo sapiens]
Length = 586
Score = 62.0 bits (149), Expect = 2e-09
Identities = 50/188 (26%), Positives = 86/188 (45%), Gaps = 28/188 (14%)
Query: 77 VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
V+++ + +YMF ++I+ D F P+ E + + +E V+
Sbjct: 83 VLLHILGALYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGA 125
Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
T MA GSS PE+ S+I V FI GD+G TIVGSA FN+ IIG+C G+
Sbjct: 126 TFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVV 179
Query: 196 KIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRL 255
++ ++ S++ I + +++ + WEGL+ + + +L+ K
Sbjct: 180 RL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQ 235
Query: 256 LFYKYMHK 263
F+ K
Sbjct: 236 AFFTVKQK 243
Score = 60.5 bits (145), Expect = 7e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 752 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 811
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 479
Query: 812 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 871
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 536
Query: 872 VL 873
VL
Sbjct: 537 VL 538
Score = 35.4 bits (80), Expect = 0.25
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 779 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 834
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
Query: 835 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 868
V + W + V ++ +++++ + F+
Sbjct: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
Score = 33.5 bits (75), Expect = 0.93
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ + +G+
Sbjct: 450 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 500
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 60.8 bits (146), Expect = 5e-09
Identities = 50/172 (29%), Positives = 83/172 (48%), Gaps = 40/172 (23%)
Query: 77 VIVYFVALIYMFLGVSIIADR-FMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
V+++ ++Y+F+ ++I+ D F+ ++ VIT + + +E V+
Sbjct: 455 VVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQI------------------SEDVAG 496
Query: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194
T MA G SAPE+ SLI V FI+ ++G TIVGSA FN+ +IG C +
Sbjct: 497 ATFMAAGGSAPELFTSLIGV----FISHSNVGIGTIVGSAVFNILFVIGTCSLF-----S 547
Query: 195 RKIKHLRVFFITAAWSIFAYIWLY-----MILAVFSPGVVQVWEGLLTLFFF 241
R+I +L W +F + Y M++ F ++ WE LL L +
Sbjct: 548 REILNL------TWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAY 593
Score = 50.4 bits (119), Expect = 7e-06
Identities = 46/178 (25%), Positives = 77/178 (43%), Gaps = 15/178 (8%)
Query: 707 DEDEDESGEERLPSCFDY--------VMHFLTVFWKVLFACVPPTEYCHGWACFAV---- 754
+E+E+E G E P D+ + FL L+ VP F
Sbjct: 885 EEEEEEKGNEE-PLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLG 943
Query: 755 SILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADAS 814
SI+ I M + ++ A G TIG+ + + + +A GTS+PD S A + + D +
Sbjct: 944 SIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGL-GDMA 1002
Query: 815 IGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISV 872
+ + GSN ++ +G+ + W + ++ LQ S G V LF + FV S+
Sbjct: 1003 VSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVS-SNGLFCAIVLLFLMLLFVISSI 1059
Score = 32.0 bits (71), Expect = 2.7
Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 3/51 (5%)
Query: 130 NETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
+E + LT++A G+S P+++ S+I V G GD+ S+ VGS F++ +
Sbjct: 969 SEEIMGLTILAAGTSIPDLITSVI-VARKGL--GDMAVSSSVGSNIFDITV 1016
>gi|54607027 integrin beta 4 isoform 2 precursor [Homo sapiens]
Length = 1805
Score = 47.8 bits (112), Expect = 5e-05
Identities = 39/143 (27%), Positives = 68/143 (47%), Gaps = 10/143 (6%)
Query: 487 VRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIG 546
+R E++ ++ + AI +P A L V +TI+ + + +FE VS
Sbjct: 950 IRPEDDDEKQLLVEAI--DVPAGTATLGRRLV-NITIIKEQARDVVSFEQPEFSVSRGDQ 1006
Query: 547 VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEE 606
V + V+R G V +RT +GTA+ G D+ GEL F+ E K ++VK+++ +
Sbjct: 1007 VARIPVIRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKELQVKLLELQ 1065
Query: 607 EYE------RQENFFIALGEPKW 623
E + + F + L PK+
Sbjct: 1066 EVDSLLRGRQVRRFHVQLSNPKF 1088
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 7/77 (9%)
Query: 416 LTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIID----D 471
+ V+R+ D K+ V Y+T+DG+A DY EG ++ +PGE KE V +++ D
Sbjct: 1010 IPVIRRVLDGGKSQ-VSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068
Query: 472 DIF--EEDEHFFVRLSN 486
+ + F V+LSN
Sbjct: 1069 SLLRGRQVRRFHVQLSN 1085
>gi|54607035 integrin beta 4 isoform 1 precursor [Homo sapiens]
Length = 1822
Score = 47.8 bits (112), Expect = 5e-05
Identities = 39/143 (27%), Positives = 68/143 (47%), Gaps = 10/143 (6%)
Query: 487 VRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIG 546
+R E++ ++ + AI +P A L V +TI+ + + +FE VS
Sbjct: 950 IRPEDDDEKQLLVEAI--DVPAGTATLGRRLV-NITIIKEQARDVVSFEQPEFSVSRGDQ 1006
Query: 547 VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEE 606
V + V+R G V +RT +GTA+ G D+ GEL F+ E K ++VK+++ +
Sbjct: 1007 VARIPVIRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKELQVKLLELQ 1065
Query: 607 EYE------RQENFFIALGEPKW 623
E + + F + L PK+
Sbjct: 1066 EVDSLLRGRQVRRFHVQLSNPKF 1088
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 7/77 (9%)
Query: 416 LTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIID----D 471
+ V+R+ D K+ V Y+T+DG+A DY EG ++ +PGE KE V +++ D
Sbjct: 1010 IPVIRRVLDGGKSQ-VSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068
Query: 472 DIF--EEDEHFFVRLSN 486
+ + F V+LSN
Sbjct: 1069 SLLRGRQVRRFHVQLSN 1085
>gi|54607033 integrin beta 4 isoform 3 precursor [Homo sapiens]
Length = 1752
Score = 47.8 bits (112), Expect = 5e-05
Identities = 39/143 (27%), Positives = 68/143 (47%), Gaps = 10/143 (6%)
Query: 487 VRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIG 546
+R E++ ++ + AI +P A L V +TI+ + + +FE VS
Sbjct: 950 IRPEDDDEKQLLVEAI--DVPAGTATLGRRLV-NITIIKEQARDVVSFEQPEFSVSRGDQ 1006
Query: 547 VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEE 606
V + V+R G V +RT +GTA+ G D+ GEL F+ E K ++VK+++ +
Sbjct: 1007 VARIPVIRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKELQVKLLELQ 1065
Query: 607 EYE------RQENFFIALGEPKW 623
E + + F + L PK+
Sbjct: 1066 EVDSLLRGRQVRRFHVQLSNPKF 1088
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 7/77 (9%)
Query: 416 LTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIID----D 471
+ V+R+ D K+ V Y+T+DG+A DY EG ++ +PGE KE V +++ D
Sbjct: 1010 IPVIRRVLDGGKSQ-VSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068
Query: 472 DIF--EEDEHFFVRLSN 486
+ + F V+LSN
Sbjct: 1069 SLLRGRQVRRFHVQLSN 1085
>gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens]
Length = 2179
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/92 (28%), Positives = 45/92 (48%), Gaps = 2/92 (2%)
Query: 396 SKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVV- 454
S + + Y+ EN G + L ++R+G M +V K SA G D+ ++
Sbjct: 1741 SHIEWSQTEYEVCENVGLLPLEIIRRGYSMDSA-FVGIKVNQVSAAVGKDFTVIPSKLIQ 1799
Query: 455 LKPGETQKEFSVGIIDDDIFEEDEHFFVRLSN 486
PG + K +++ I D + E+DE F V L++
Sbjct: 1800 FDPGMSTKMWNIAITYDGLEEDDEVFEVILNS 1831
>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
Length = 976
Score = 36.6 bits (83), Expect = 0.11
Identities = 25/76 (32%), Positives = 44/76 (57%), Gaps = 5/76 (6%)
Query: 609 ERQENFFIALGEPKWMERGISDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESY 668
E E +AL + + +E +S +T++ L +E E R+AE+ K +L +LE I+E+Y
Sbjct: 335 EDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELE-SIKETY 393
Query: 669 EFKT----TVDKLIKK 680
E + T+ +LIK+
Sbjct: 394 ENTSHQVHTLRRLIKE 409
>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
Length = 1027
Score = 36.6 bits (83), Expect = 0.11
Identities = 25/76 (32%), Positives = 44/76 (57%), Gaps = 5/76 (6%)
Query: 609 ERQENFFIALGEPKWMERGISDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESY 668
E E +AL + + +E +S +T++ L +E E R+AE+ K +L +LE I+E+Y
Sbjct: 386 EDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELE-SIKETY 444
Query: 669 EFKT----TVDKLIKK 680
E + T+ +LIK+
Sbjct: 445 ENTSHQVHTLRRLIKE 460
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,402,475
Number of Sequences: 37866
Number of extensions: 1544105
Number of successful extensions: 4489
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 4255
Number of HSP's gapped (non-prelim): 135
length of query: 921
length of database: 18,247,518
effective HSP length: 112
effective length of query: 809
effective length of database: 14,006,526
effective search space: 11331279534
effective search space used: 11331279534
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.