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Search of human proteins with 33859670
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33859670 leucine-rich repeats and calponin homology (CH)
domain containing 1 [Homo sapiens]
(728 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 1462 0.0
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 547 e-155
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 430 e-120
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 407 e-113
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 103 4e-22
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 98 2e-20
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 98 2e-20
gi|238908508 leucine-rich repeat and death domain-containing pro... 95 2e-19
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 95 3e-19
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 94 4e-19
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 94 6e-19
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 93 8e-19
gi|61742786 leucine rich repeat and death domain containing prot... 93 1e-18
gi|61742784 leucine rich repeat and death domain containing prot... 93 1e-18
gi|45827729 scribble isoform b [Homo sapiens] 90 8e-18
gi|45827731 scribble isoform a [Homo sapiens] 90 8e-18
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 89 1e-17
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 88 3e-17
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 88 3e-17
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 87 4e-17
gi|53729363 leucine rich repeat and sterile alpha motif containi... 86 9e-17
gi|53729361 leucine rich repeat and sterile alpha motif containi... 86 9e-17
gi|53729359 leucine rich repeat and sterile alpha motif containi... 86 9e-17
gi|61742782 leucine rich repeat and death domain containing prot... 86 2e-16
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 84 6e-16
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 83 8e-16
gi|4503743 flightless I homolog [Homo sapiens] 83 1e-15
gi|197333706 leucine rich repeat containing 8 family, member D [... 82 2e-15
gi|34222199 leucine rich repeat containing 8 family, member D [H... 82 2e-15
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 81 3e-15
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 1462 bits (3786), Expect = 0.0
Identities = 728/728 (100%), Positives = 728/728 (100%)
Query: 1 MATPGSEPQPFVPALSVATLHPLHHPHHHHHHHQHHGGTGAPGGAGGGGGGSGGFNLPLN 60
MATPGSEPQPFVPALSVATLHPLHHPHHHHHHHQHHGGTGAPGGAGGGGGGSGGFNLPLN
Sbjct: 1 MATPGSEPQPFVPALSVATLHPLHHPHHHHHHHQHHGGTGAPGGAGGGGGGSGGFNLPLN 60
Query: 61 RGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV 120
RGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV
Sbjct: 61 RGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV 120
Query: 121 SLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSL 180
SLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSL
Sbjct: 121 SLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSL 180
Query: 181 PEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDF 240
PEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDF
Sbjct: 181 PEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDF 240
Query: 241 SCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSL 300
SCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSL
Sbjct: 241 SCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSL 300
Query: 301 YLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQI 360
YLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQI
Sbjct: 301 YLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQI 360
Query: 361 IKEDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAED 420
IKEDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAED
Sbjct: 361 IKEDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAED 420
Query: 421 CEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNL 480
CEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNL
Sbjct: 421 CEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNL 480
Query: 481 YPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRENSPAVSPTTN 540
YPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRENSPAVSPTTN
Sbjct: 481 YPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRENSPAVSPTTN 540
Query: 541 STAPFGLKPRSVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHE 600
STAPFGLKPRSVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHE
Sbjct: 541 STAPFGLKPRSVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHE 600
Query: 601 DLGAALMDGVVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPE 660
DLGAALMDGVVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPE
Sbjct: 601 DLGAALMDGVVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPE 660
Query: 661 ADLCSPCDILQLDFRHIRKTVDTLLALGEKAPPPTSALRSRDLIGFCLVHILFIVLVYIT 720
ADLCSPCDILQLDFRHIRKTVDTLLALGEKAPPPTSALRSRDLIGFCLVHILFIVLVYIT
Sbjct: 661 ADLCSPCDILQLDFRHIRKTVDTLLALGEKAPPPTSALRSRDLIGFCLVHILFIVLVYIT 720
Query: 721 YHWNALSA 728
YHWNALSA
Sbjct: 721 YHWNALSA 728
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 547 bits (1410), Expect = e-155
Identities = 340/721 (47%), Positives = 426/721 (59%), Gaps = 102/721 (14%)
Query: 40 GAPGGAGGGGGGSGG-----------FNLPLNRG----------------LERALEEAAN 72
G GGAGGGGGG GG F P G L+RALEEA +
Sbjct: 30 GGGGGAGGGGGGGGGTLVVPIPVPTLFGQPFPNGPPWNPGSLQPQHTVRSLDRALEEAGS 89
Query: 73 SGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCI 132
SG L+LS RKL++FP + G+DL+DT QADLS+NR E+P ++ F LE LNLYHNCI
Sbjct: 90 SGILSLSGRKLRDFPGS---GYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCI 146
Query: 133 RVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLME 192
+ IPEAI NLQMLTYLN+SRN LS LP L LPLKVL+ SNNKL S+PEEIG+LK LME
Sbjct: 147 KTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVVSNNKLVSIPEEIGKLKDLME 206
Query: 193 LDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICF 252
LD+SCNEI LPQQ+G+L SLRELN+RRN L VLP EL DLPLVK DFSCNKV IP+C+
Sbjct: 207 LDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIPVCY 266
Query: 253 REMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQAC--QIKTADSLYLHTMERPHL 310
R++ LQV++L+NNPLQ PPAQIC KGKVHIFKYL+IQAC K DSL L ++ +
Sbjct: 267 RKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLSKRMP 326
Query: 311 HQHVEDGKKD--------SDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQIIK 362
Q + D +D DSG+GSDNG+KRLS TEPSD+DTVSL+ +S EQ +
Sbjct: 327 SQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPSDDDTVSLHSQVSE-SNREQTSR 385
Query: 363 EDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAEDCE 422
DS S + QE + D + E ++ + F+++ E C
Sbjct: 386 NDSHIIGSKTDSQKDQE-------VYDFVDPNTEDVAVPEQGNAHIGSFVSFFKGKEKCS 438
Query: 423 ELLRIEEDV----HWQTEGIISSSKDQDMDIAMIEQLRE-AVDLLQDPNGLSTDITERSV 477
E R E++ + E ++ ++++D D+ + LR+ A LLQ SV
Sbjct: 439 EKSRKNEELGDEKRLEKEQLL--AEEEDDDLKEVTDLRKIAAQLLQQEQKNRILNHSTSV 496
Query: 478 LNLYPMGSAEA--------------------LELQDSALNGQIQLETSPVC--------- 508
+ P + E LE Q ++ Q E+ P+
Sbjct: 497 MRNKPKQTVECEKSVSADEVNSPLSPLTWQPLENQKDQIDEQPWPESHPIIWQSEERRRS 556
Query: 509 -----------EVQSDLTLQSNGSQYSPN-EIRENSPAVSPTTNST-----APFGLKPRS 551
++ + N Q S N + SP S + T +PFGLKPRS
Sbjct: 557 KQIRKEYFKYKSMRKSSSGNENDEQDSDNANMSTQSPVSSEEYDRTDGFSHSPFGLKPRS 616
Query: 552 VFLRPQR-NLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDGV 610
F R R + DP FT+RRKME +REE+E + QLR ++E RLKV L +D+GAALMDGV
Sbjct: 617 AFSRSSRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDGV 676
Query: 611 VLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEADLCSPCDIL 670
VLCHL NHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFL+AC+KLGV + LC P IL
Sbjct: 677 VLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLCLPHHIL 736
Query: 671 Q 671
+
Sbjct: 737 E 737
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 430 bits (1105), Expect = e-120
Identities = 298/712 (41%), Positives = 389/712 (54%), Gaps = 72/712 (10%)
Query: 41 APGGAGGGGGGS-----GGFNLPLNRGLERALEEAANSGGLNLSARKLKEFPRTAAPGHD 95
AP AGG + G LP R ERALEEA +G LNLS R+LK FPR AA +D
Sbjct: 7 APLAAGGEEAAATTSVPGSPGLPGRRSAERALEEAVATGTLNLSNRRLKHFPRGAARSYD 66
Query: 96 LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQL 155
LSD QADLS+NR EVP C VSLE L+LYHNC+R + A+ NL LTYLNLSRNQL
Sbjct: 67 LSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQL 126
Query: 156 SALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRE 215
S LP +C LPL+VLI SNNKLG+LP +IG L L +LDVS NE+ +LP ++ L SLR+
Sbjct: 127 SLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRD 186
Query: 216 LNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
LNVRRN L LP+EL DLPLV+ DFSCN+V IP+ F ++ LQV+LL++NPLQSPPAQ+
Sbjct: 187 LNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQV 246
Query: 276 CTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQ----------HVEDGKKDSDSGV 325
C KGK+HIFKYLS +A Q +L RP H DG DSG
Sbjct: 247 CLKGKLHIFKYLSTEAGQ--RGSALGDLAPSRPPSFSPCPAEDLFPGHRYDG--GLDSGF 302
Query: 326 GS-DNGDKRLSATEPSDEDTVSLNVPMSNIMEE---EQIIKEDSCHRLSPVKGEFHQEFQ 381
S D+G KR S E +DE + L+ +S + E + KED PV+ +F
Sbjct: 303 HSVDSGSKRWSGNESTDEFS-ELSFRISELAREPRGPRERKEDGSADGDPVQIDFIDSHV 361
Query: 382 PEPSLLGDSTNSGEERDQ----------FTDRA-DGLHSEFMNYKARAEDCEELLRIEED 430
P G+ G +Q +RA E + R D +L + E
Sbjct: 362 P-----GEDEERGTVEEQRPPELSPGAGDRERAPSSRREEPAGEERRRPDTLQLWQERER 416
Query: 431 VHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNLYPMGSAEALE 490
Q G + + D + LR V G + ++ +++ N P SA
Sbjct: 417 RQQQQSGAWGAPR---KDSLLKPGLRAVV-------GGAAAVSTQAMHNGSPKSSAS--- 463
Query: 491 LQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRENSPAVSPTTNSTAPFGLKPR 550
Q A GQ +P Q L + + +P + S S++ G P
Sbjct: 464 -QAGAAAGQGAPAPAPAS--QEPLPIAGPATAPAPRPLGSIQRPNSFLFRSSSQSGSGPS 520
Query: 551 SVFLRPQRNLESIDPQFTIR-RKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDG 609
S P +R R+ Q+ +EK+L+ QLR+ +E RL+ L EDL AL G
Sbjct: 521 S-------------PDSVLRPRRYPQVPDEKDLMTQLRQVLESRLQRPLPEDLAEALASG 567
Query: 610 VVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEADLCSPCDI 669
V+LC L N +RPRSV IHVPSPAVPKLS K R+NVE+FLEACRK+GVPEADLCSP D+
Sbjct: 568 VILCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMGVPEADLCSPSDL 627
Query: 670 LQLDFRHIRKTVDTLLALGEKAPPPTSALRSRDLIGFCLVHILFIVLVYITY 721
LQ R +R ++ + +G KA PP L GF + +++ ++L+Y+TY
Sbjct: 628 LQGTARGLRTALEAVKRVGGKALPP--LWPPSGLGGFVVFYVVLMLLLYVTY 677
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 407 bits (1046), Expect = e-113
Identities = 282/689 (40%), Positives = 374/689 (54%), Gaps = 106/689 (15%)
Query: 42 PGGAGGGGGGSGGFNLPLNRGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQ 101
P G G G G ++ R L+RALEEAA +G L+LS RKL+EFPR AA HDL+DT +
Sbjct: 32 PSSGAGPGFGPGSWS----RSLDRALEEAAVTGVLSLSGRKLREFPRGAA-NHDLTDTTR 86
Query: 102 ADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPAC 161
ADLS+NRL E+P+E CHFVSLE LNLY NCIR IPEAI+NLQ LT+LN+SRNQLS LP
Sbjct: 87 ADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVH 146
Query: 162 LCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRN 221
LC LPLKVLIASNNKL SLPEEIG L+ LMELDVSCNEI +P QIG L++LR+LNVRRN
Sbjct: 147 LCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRN 206
Query: 222 YLKVLPQELVDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKV 281
+L LP+EL +LPL++ DFSCNK+ IP+C+R ++ LQ + L+NNPLQSPPAQIC KGKV
Sbjct: 207 HLVHLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKV 266
Query: 282 HIFKYLSIQACQIKTADSLYLHTMERP----HLHQHVEDGKKDS--DSGVGS-DNGDK-- 332
HIFKYL+IQAC K A L + RP H+ + + DSG S D+GDK
Sbjct: 267 HIFKYLNIQAC--KIAPDLPDYD-RRPLGFGSCHEELYSSRPYGALDSGFNSVDSGDKRW 323
Query: 333 -----------------------RLSATEPSDEDTVSLNVPMSNIMEE-EQIIKEDSCHR 368
RL E+ SL V + + +QI DSC
Sbjct: 324 SGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGSLVVTNGGVEHDLDQIDYIDSC-T 382
Query: 369 LSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAEDCEELLRIE 428
+ E Q P+P L + E+ + + + + + ED L +
Sbjct: 383 AEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISHEGSPVKPVAIREFQKTEDMRRYLH-Q 441
Query: 429 EDVHWQTEGIISSSKDQ------DMDI-----AMIEQLREAVDLL----QDPNGLSTDIT 473
V + ++S S D+++ ++E+ R L ++ + I
Sbjct: 442 NRVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTRREAQLAALQYEEEKIRTKQIQ 501
Query: 474 ERSVLNLYPMGSAEALELQDSALNG-----------QIQLETSPVCEVQSDLTLQS---- 518
+VL+ ++++ + Q L+G + S +C S L
Sbjct: 502 RDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQHTDDSALCMSLSGLNQVGCAAT 561
Query: 519 --NGSQYSP--NEIRENSPAVSPTTNS-------TAPFGL------KPRSVFLR------ 555
+ S ++P ++ R N+ SP T + + P + +P S R
Sbjct: 562 LPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYSFPAAIQRNQPQRPESFLFRAGVRAE 621
Query: 556 ---------PQRNLESIDPQFTIRRKMEQMREEK-ELVEQLRESIEMRLKVSLHEDLGAA 605
P + D +I + + REE+ EL++QLR+ IE RLKVSL DLGAA
Sbjct: 622 TNKGHASPLPPSAAPTTDSTDSITGQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAA 681
Query: 606 LMDGVVLCHLVNHIRPRSVASIHVPSPAV 634
L DGVVLCHL NH+RPRSV SIHVPSPAV
Sbjct: 682 LTDGVVLCHLANHVRPRSVPSIHVPSPAV 710
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 103 bits (258), Expect = 4e-22
Identities = 79/253 (31%), Positives = 117/253 (46%), Gaps = 55/253 (21%)
Query: 96 LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQL 155
LS Q LS N+L VP + +LE+LN ++N I +P I +LQ L +LNL N+L
Sbjct: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
Query: 156 SALPACLCGLP--------------------------LKVLIASNNKLGSLPEEIGQLKQ 189
+ LP LP L+ L S+N LP +IG+L +
Sbjct: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
Query: 190 LMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIP 249
L L + N++ +LP++IG+L L+EL+++ N L VLP EL +L L
Sbjct: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLT------------- 205
Query: 250 ICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPH 309
Q QV ENNP +P A G H+F+Y I++ YL+ H
Sbjct: 206 ------GQKQVFKAENNPWVTPIADQFQLGVSHVFEY-------IRSETYKYLYGR---H 249
Query: 310 LHQHVEDGKKDSD 322
+ + E KK++D
Sbjct: 250 MQANPEPPKKNND 262
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 98.2 bits (243), Expect = 2e-20
Identities = 78/205 (38%), Positives = 111/205 (54%), Gaps = 10/205 (4%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVP---MELCHFVSLEILNLYHNCI 132
LNL L+E P G L L +NR +P EL H L L++ HN +
Sbjct: 68 LNLGNNGLEEVPEGL--GSALGSLRVLVLRRNRFARLPPAVAELGHH--LTELDVSHNRL 123
Query: 133 RVIPEAIVN-LQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQL 190
+ +V+ L+ L LNLS NQL ALPA L L L+ L S N+L LP+ + L +L
Sbjct: 124 TALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRL 183
Query: 191 MELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVL-VIP 249
LDV N++TA P+Q+ QL +L EL+V N L+ LP+++ L +K + L +P
Sbjct: 184 RTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLP 243
Query: 250 ICFREMKQLQVLLLENNPLQSPPAQ 274
F E+ L+ L+L+NN LQ+ PAQ
Sbjct: 244 AGFCELASLESLMLDNNGLQALPAQ 268
Score = 81.3 bits (199), Expect = 3e-15
Identities = 63/202 (31%), Positives = 97/202 (48%), Gaps = 5/202 (2%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
LNLS +L P L+ + D+S NRL +P L L L++ HN +
Sbjct: 140 LNLSHNQLPALPAQLGA---LAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAF 196
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLMELD 194
P ++ L L L++S N+L LP + L LK+L S +LG+LP +L L L
Sbjct: 197 PRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLM 256
Query: 195 VSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLP-LVKFDFSCNKVLVIPICFR 253
+ N + ALP Q L+ L+ LN+ N + P L+ L L + S N++ +P
Sbjct: 257 LDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLIS 316
Query: 254 EMKQLQVLLLENNPLQSPPAQI 275
+ +L L L+NN ++ P I
Sbjct: 317 GLGRLLTLWLDNNRIRYLPDSI 338
Score = 79.7 bits (195), Expect = 9e-15
Identities = 59/184 (32%), Positives = 85/184 (46%), Gaps = 23/184 (12%)
Query: 104 LSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLC 163
LS L +P C SLE L L +N ++ +P LQ L LNLS N PA L
Sbjct: 234 LSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALL 293
Query: 164 GLP-LKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNY 222
L L+ L S N+L S+P I L +L+ L + N I LP I +L L EL ++ N
Sbjct: 294 PLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQ 353
Query: 223 LKVLPQELVDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVH 282
+ VLP F ++ ++ + +++NPL PP ++C KG +
Sbjct: 354 IAVLPDH----------------------FGQLSRVGLWKIKDNPLIQPPYEVCMKGIPY 391
Query: 283 IFKY 286
I Y
Sbjct: 392 IAAY 395
Score = 30.0 bits (66), Expect = 7.9
Identities = 30/116 (25%), Positives = 43/116 (37%), Gaps = 28/116 (24%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPM--------------------- 114
LNLS+ +EFP P L+ + LS+N+L VP
Sbjct: 278 LNLSSNLFEEFPAALLP---LAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYL 334
Query: 115 --ELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALP--ACLCGLP 166
+ LE L L N I V+P+ L + + N L P C+ G+P
Sbjct: 335 PDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIP 390
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 98.2 bits (243), Expect = 2e-20
Identities = 72/222 (32%), Positives = 111/222 (50%), Gaps = 28/222 (12%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
L L LK P++ H L+ + DL N E+P L +L L + +N ++V+
Sbjct: 166 LELRENHLKTLPKSM---HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVL 222
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLM--- 191
P +I L+ML YL++S+N++ + + G L+ L+ S+N L LP+ IG LK+L
Sbjct: 223 PGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLK 282
Query: 192 --------------------ELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELV 231
E D SCNE+ +LP IG L SLR L V N+L LP+E+
Sbjct: 283 VDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIG 342
Query: 232 DLPLVK-FDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPP 272
V NK+ +P +M++L+VL L +N L++ P
Sbjct: 343 SCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLP 384
Score = 85.1 bits (209), Expect = 2e-16
Identities = 75/234 (32%), Positives = 112/234 (47%), Gaps = 28/234 (11%)
Query: 64 ERALEEAANSGGLNLSARKLKEFPRT----------AAPGHDLSDTV----------QAD 103
ER LEE L L A +++E P+ + P +DLS+ + D
Sbjct: 45 ERTLEE------LYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELD 98
Query: 104 LSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLC 163
+SKN + E P + L I+ N I +P+ L LT L L+ L LPA
Sbjct: 99 ISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFG 158
Query: 164 GL-PLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNY 222
L L++L N L +LP+ + +L QL LD+ NE LP+ + Q+++LREL + N
Sbjct: 159 RLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNA 218
Query: 223 LKVLPQELVDLP-LVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
L+VLP + L LV D S N++ + + + L+ LLL +N LQ P I
Sbjct: 219 LQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSI 272
Score = 58.5 bits (140), Expect = 2e-08
Identities = 59/211 (27%), Positives = 88/211 (41%), Gaps = 50/211 (23%)
Query: 63 LERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSL 122
L L++ N L + L+ P + L V D+SKNR+ V M++ +L
Sbjct: 199 LPEVLDQIQNLRELWMDNNALQVLPGSIGK---LKMLVYLDMSKNRIETVDMDISGCEAL 255
Query: 123 EILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPA------------CLCG------ 164
E L L N ++ +P++I L+ LT L + NQL+ LP C C
Sbjct: 256 EDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLP 315
Query: 165 ---------------------LP--------LKVLIASNNKLGSLPEEIGQLKQLMELDV 195
LP + V+ +NKL LPEEIGQ+++L L++
Sbjct: 316 STIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNL 375
Query: 196 SCNEITALPQQIGQLKSLRELNVRRNYLKVL 226
S N + LP +LK L L + N K L
Sbjct: 376 SDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 95.1 bits (235), Expect = 2e-19
Identities = 61/206 (29%), Positives = 97/206 (47%), Gaps = 29/206 (14%)
Query: 103 DLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACL 162
DL KN++ ++P + + +SL +L L N P + L+ L L+LS NQL + + +
Sbjct: 539 DLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDI 598
Query: 163 CGL---------------------------PLKVLIASNNKLGSLPEEIGQLKQLMELDV 195
C L L + KL LP E+ + QL ELD+
Sbjct: 599 CNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDI 658
Query: 196 SCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVKFDFSCNKVLVIPICFRE 254
S N I +P+ IG+L++L L+ N + LP L+ L L + + S N + +P
Sbjct: 659 SNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYN 718
Query: 255 MKQLQVLLLENNPLQSPPAQICTKGK 280
+ L+ + ++NPL PP +IC KGK
Sbjct: 719 IFSLKEINFDDNPLLRPPVEIC-KGK 743
Score = 84.7 bits (208), Expect = 3e-16
Identities = 65/234 (27%), Positives = 114/234 (48%), Gaps = 12/234 (5%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
L+LS KL E P+ H L++ + +++N +V++ + H ++ L N I +
Sbjct: 400 LSLSDNKLTELPKYI---HKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDV 456
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMELD 194
P I N Q + + LS N++ P LC L L L + N + +P +I KQL+ L+
Sbjct: 457 PIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLE 516
Query: 195 VSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVKFDFSCNKVLVIPICFR 253
+S N++ + L +L+ L++ +N +K +P + ++ L CNK P
Sbjct: 517 LSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELC 576
Query: 254 EMKQLQVLLLENNPLQSPPAQICT-KG------KVHIFKYLSIQACQIKTADSL 300
++ LQVL L N LQ + IC KG + F + I+ CQ+++ + L
Sbjct: 577 TLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQL 630
Score = 81.6 bits (200), Expect = 2e-15
Identities = 61/201 (30%), Positives = 100/201 (49%), Gaps = 26/201 (12%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
LN+S + P+ + L + Q N + P +L +LEIL+L N +R I
Sbjct: 216 LNVSHNHISHIPKEIS---QLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHI 272
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMELD 194
P+ + +L+ L LNL NQL+ P LC LP L L + N + SLP+EI +LK L L
Sbjct: 273 PDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLL 332
Query: 195 VSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFRE 254
+ N++T L +I QL ++EL + N L+V+ ++
Sbjct: 333 MDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI----------------------EN 370
Query: 255 MKQLQVLLLENNPLQSPPAQI 275
++L++L+L+ N L++ P +I
Sbjct: 371 FRELRILILDKNLLKNIPEKI 391
Score = 77.0 bits (188), Expect = 6e-14
Identities = 53/155 (34%), Positives = 81/155 (52%), Gaps = 3/155 (1%)
Query: 125 LNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCG--LPLKVLIASNNKLGSLPE 182
+NL ++ P+ I+ ++ + YL L +NQ+ G L L++L N L SLP
Sbjct: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205
Query: 183 EIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVKFDFS 241
EI L L L+VS N I+ +P++I QL ++R+L NY++ P +L L L
Sbjct: 206 EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLG 265
Query: 242 CNKVLVIPICFREMKQLQVLLLENNPLQSPPAQIC 276
NK+ IP +K L+VL LE N L + P +C
Sbjct: 266 KNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC 300
Score = 75.9 bits (185), Expect = 1e-13
Identities = 59/216 (27%), Positives = 105/216 (48%), Gaps = 8/216 (3%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
LNL +L FP+ L + DL+ N + +P E+ +LE L + HN + +
Sbjct: 285 LNLEYNQLTTFPKALC---FLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFL 341
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLMELD 194
I L + L L+ N+L + + L++LI N L ++PE+I L L
Sbjct: 342 AVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLS 401
Query: 195 VSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVKFDFSCNKVLVIPICFR 253
+S N++T LP+ I +L +LR+L+V RN + + + L + +FS N + +PI +
Sbjct: 402 LSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIK 461
Query: 254 EMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSI 289
+++ + L N + P +C ++ YLS+
Sbjct: 462 NCQKIIKIELSYNKIMYFPLGLCALDSLY---YLSV 494
Score = 72.8 bits (177), Expect = 1e-12
Identities = 50/181 (27%), Positives = 93/181 (51%), Gaps = 5/181 (2%)
Query: 100 VQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALP 159
++ +LS N+++ P+ LC SL L++ N I IP I + L +L LS N+L
Sbjct: 467 IKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFS 526
Query: 160 ACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNV 218
C L LK L N++ +P I + L L + CN+ P+++ L++L+ L++
Sbjct: 527 EHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDL 586
Query: 219 RRNYLKVLPQELVDLP-LVKFDFSCNKVLVIPI--C-FREMKQLQVLLLENNPLQSPPAQ 274
N L+ + ++ +L + K +FS N+ + PI C + ++QL + ++ L P +
Sbjct: 587 SENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGE 646
Query: 275 I 275
+
Sbjct: 647 L 647
Score = 70.5 bits (171), Expect = 5e-12
Identities = 51/182 (28%), Positives = 92/182 (50%), Gaps = 2/182 (1%)
Query: 104 LSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLC 163
L KN L +P ++ LE L+L N + +P+ I L L L+++RN + + C+
Sbjct: 379 LDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCIS 438
Query: 164 GLP-LKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNY 222
L + L S N + +P EI ++++++++S N+I P + L SL L+V NY
Sbjct: 439 HLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNY 498
Query: 223 LKVLPQEL-VDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKV 281
+ +P ++ L+ + S NK+L+ F + L+ L L N ++ PA I +
Sbjct: 499 ISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISL 558
Query: 282 HI 283
H+
Sbjct: 559 HV 560
Score = 60.5 bits (145), Expect = 5e-09
Identities = 49/183 (26%), Positives = 79/183 (43%), Gaps = 16/183 (8%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
LN S+ + FP L + + +L +P EL + L+ L++ +N IR I
Sbjct: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLMELD 194
P I L+ L L+ NQ+S LP L L L+ L S N L +LP I + L E++
Sbjct: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEIN 726
Query: 195 VSCNEITALPQQIGQLKSL------------RELNVRRNYLKVLPQELVDLPLVKFDFSC 242
N + P +I + K L R+ + K++ + + F+F C
Sbjct: 727 FDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITE---TNFEFLC 783
Query: 243 NKV 245
K+
Sbjct: 784 QKL 786
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 94.7 bits (234), Expect = 3e-19
Identities = 72/237 (30%), Positives = 109/237 (45%), Gaps = 55/237 (23%)
Query: 112 VPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP----- 166
VP + +LE+LN ++N I +P I +LQ L +LNL N+L+ LP LP
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
Query: 167 ---------------------LKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQ 205
L+ L S+N LP +IG+L +L L + N++ +LP+
Sbjct: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
Query: 206 QIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLEN 265
+IG+L L+EL+++ N L VLP EL +L L Q QV EN
Sbjct: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDLT-------------------GQKQVFKAEN 162
Query: 266 NPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQHVEDGKKDSD 322
NP +P A G H+F+Y I++ YL+ H+ + E KK++D
Sbjct: 163 NPWVTPIADQFQLGVSHVFEY-------IRSETYKYLYGR---HMQANPEPPKKNND 209
Score = 33.9 bits (76), Expect = 0.55
Identities = 25/76 (32%), Positives = 38/76 (50%), Gaps = 4/76 (5%)
Query: 104 LSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLC 163
LS N +P ++ L+IL+L N + +P+ I L L L++ N+L+ LP L
Sbjct: 88 LSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELG 147
Query: 164 GLPL----KVLIASNN 175
L L +V A NN
Sbjct: 148 NLDLTGQKQVFKAENN 163
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 94.0 bits (232), Expect = 4e-19
Identities = 79/246 (32%), Positives = 118/246 (47%), Gaps = 27/246 (10%)
Query: 49 GGGSGGFNLPLNRGLERALEEAANSGGLNLSARKLKEFPRTA---------APGHDLS-- 97
GG G ++P +GL L+ A SG LNLS R L E P+ +LS
Sbjct: 19 GGRDCGTSVP--QGL---LKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFG 73
Query: 98 ---------DTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYL 148
D + +S N+L + +L +L +L+++ N + +P AI L+ L L
Sbjct: 74 ATERWWEQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKL 133
Query: 149 NLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQI 207
N+S N+L LP + L LK L +N+L + E QL L +LD+S N +T +P
Sbjct: 134 NVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASF 193
Query: 208 GQLKSLRELNVRRNYLKVLPQELVDLPLVK-FDFSCNKVLVIPICFREMKQLQVLLLENN 266
L SL LN+ N LK LP E+ + +K D + N + IP M+ L++L L N
Sbjct: 194 SSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRN 253
Query: 267 PLQSPP 272
L+ P
Sbjct: 254 KLRFLP 259
Score = 89.7 bits (221), Expect = 8e-18
Identities = 79/248 (31%), Positives = 115/248 (46%), Gaps = 25/248 (10%)
Query: 63 LERALEEAANSGGLNLSARKLKEFPRTA-------------------APGHD-LSDTVQA 102
L A+ E N LN+S KLK P + G + LS+
Sbjct: 120 LPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDL 179
Query: 103 DLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACL 162
DLS N L VP SL LNL N ++ +P I ++ L +L+ + N L +P L
Sbjct: 180 DLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPEL 239
Query: 163 CGL-PLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITAL-PQQIGQLKSLRELNVRR 220
G+ L++L NKL LP E L EL V N+I L + + L S+ L++R
Sbjct: 240 AGMESLELLYLRRNKLRFLP-EFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRD 298
Query: 221 NYLKVLPQELVDL-PLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKG 279
N LK +P E++ L L + D S N + +P + L+ L LE NPL++ +I +KG
Sbjct: 299 NKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKG 357
Query: 280 KVHIFKYL 287
+ KYL
Sbjct: 358 TQEVLKYL 365
Score = 86.7 bits (213), Expect = 7e-17
Identities = 75/269 (27%), Positives = 129/269 (47%), Gaps = 37/269 (13%)
Query: 95 DLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQ 154
+L + + ++S N+L +P E+ + +L+ L L HN + I E L L L+LS N
Sbjct: 126 ELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNH 185
Query: 155 LSALPACLCGLPLKV-LIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSL 213
L+ +PA L V L S+N+L SLP EI ++K+L LD + N + +P ++ ++SL
Sbjct: 186 LTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESL 245
Query: 214 RELNVRRNYLKVLPQ-----------------ELVDLPLVK-------FDFSCNKVLVIP 249
L +RRN L+ LP+ E+++ +K D NK+ +P
Sbjct: 246 ELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVP 305
Query: 250 ICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPH 309
++ L+ L L NN + S P + G +H+ K+L+++ L T+ R
Sbjct: 306 DEIILLRSLERLDLSNNDISSLPYSL---GNLHL-KFLALEGNP--------LRTIRREI 353
Query: 310 LHQHVEDGKKDSDSGVGSDNGDKRLSATE 338
+ + ++ K S + D + SATE
Sbjct: 354 ISKGTQEVLKYLRSKIKDDGPSQSESATE 382
Score = 73.6 bits (179), Expect = 6e-13
Identities = 47/152 (30%), Positives = 84/152 (55%), Gaps = 4/152 (2%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
+N S +L E P+ ++ V DLS N+L + +ELC L L+L +N + +
Sbjct: 430 INFSKNQLCEIPKRMVELKEMVSDV--DLSFNKLSFISLELCVLQKLTFLDLRNNFLNSL 487
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSL-PEEIGQLKQLMEL 193
PE + +L L +NLS N+ LP L + L+ ++ SNN++GS+ P+++ ++ L L
Sbjct: 488 PEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTL 547
Query: 194 DVSCNEITALPQQIGQLKSLRELNVRRNYLKV 225
D+ N++ +P ++G +LR L + N +V
Sbjct: 548 DLQNNDLLQIPPELGNCVNLRTLLLDGNPFRV 579
Score = 73.2 bits (178), Expect = 8e-13
Identities = 52/170 (30%), Positives = 86/170 (50%), Gaps = 26/170 (15%)
Query: 130 NCIRVIPEAIVNLQMLT-YLNLSRNQLSALPACLCGLPLKV------------------- 169
+C +P+ ++ + LNLS LS +P C+ + + +
Sbjct: 22 DCGTSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQ 81
Query: 170 -----LIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLK 224
LI SNNKL SL +++ L L LD+ N++T+LP I +L++L++LNV N LK
Sbjct: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
Query: 225 VLPQELVDLPLVK-FDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPA 273
+LP+E+ +L +K N++ I F ++ L+ L L NN L + PA
Sbjct: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPA 191
Score = 65.5 bits (158), Expect = 2e-10
Identities = 55/200 (27%), Positives = 93/200 (46%), Gaps = 34/200 (17%)
Query: 120 VSLEILNLYHNCIRVIPEAI---VNLQMLTYLNLSRNQLSALPACLCGLPLKVLIA---- 172
++L+IL+ +IP+ + V ++T +N S+NQL +P + + LK +++
Sbjct: 399 ITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRM--VELKEMVSDVDL 456
Query: 173 SNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVD 232
S NKL + E+ L++L LD+ N + +LP+++ L L+ +N+ N K+LP+ L
Sbjct: 457 SFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYR 516
Query: 233 L-------------------------PLVKFDFSCNKVLVIPICFREMKQLQVLLLENNP 267
+ L D N +L IP L+ LLL+ NP
Sbjct: 517 IFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNP 576
Query: 268 LQSPPAQICTKGKVHIFKYL 287
+ P A I KG I +YL
Sbjct: 577 FRVPRAAILMKGTAAILEYL 596
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 93.6 bits (231), Expect = 6e-19
Identities = 64/177 (36%), Positives = 102/177 (57%), Gaps = 4/177 (2%)
Query: 95 DLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCI-RVIPEAIVNLQMLTYLNLSRN 153
+L+ +L N L EVP E+ + SL+ L+L N I R P A LQ L LNL+ N
Sbjct: 58 NLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNN 117
Query: 154 QLSALPACLCGLPLKVLIASN-NKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKS 212
L+ LP + L ++ N N+L S+P E+ L+ L+EL ++ N++ +P++I LK
Sbjct: 118 HLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKK 177
Query: 213 LRELNVRRNYLKVLPQELVDLPLVK-FDFSCNKVLVIPICFREMKQLQVLLLENNPL 268
L++L + RN + VLP+EL DL ++ D + N + + P F+++K L+ E NPL
Sbjct: 178 LQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK-LREFYCEGNPL 233
Score = 84.7 bits (208), Expect = 3e-16
Identities = 65/225 (28%), Positives = 110/225 (48%), Gaps = 27/225 (12%)
Query: 61 RGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV 120
R L +AL N+ + L+ +K+ + P L V L N + +V ELC+
Sbjct: 4 RLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLV---LQNNLIPKVCPELCNLT 60
Query: 121 SLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLC-GLPLKVLI-ASNNKLG 178
L LNL +N + +PE + L L L+LS N++ C GL +L+ +NN L
Sbjct: 61 QLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLT 120
Query: 179 SLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKF 238
LP+E+ +LK L + ++ N++ ++P+++ L++L EL + N L +P+E +KF
Sbjct: 121 QLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEE------IKF 174
Query: 239 DFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHI 283
+K+LQ LLL N + P ++C K+ I
Sbjct: 175 ----------------LKKLQKLLLARNNIGVLPEELCDLKKLRI 203
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 93.2 bits (230), Expect = 8e-19
Identities = 65/193 (33%), Positives = 103/193 (53%), Gaps = 24/193 (12%)
Query: 100 VQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALP 159
V+ +L+ N+L ++P ++ VSLE+L L +N ++ +P + NL+ L L+L N+L +LP
Sbjct: 405 VELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLP 464
Query: 160 ACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNV 218
+ L L+ L+ +NN+L +LP IG L L L + N +T LP++IG L++L EL +
Sbjct: 465 NEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYL 524
Query: 219 RRN-YLKVLPQELVDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICT 277
N L LP EL C+K L ++ +EN PL P QI
Sbjct: 525 NDNPNLHSLPFELA---------LCSK-------------LSIMSIENCPLSHLPPQIVA 562
Query: 278 KGKVHIFKYLSIQ 290
G I ++L +Q
Sbjct: 563 GGPSFIIQFLKMQ 575
Score = 85.5 bits (210), Expect = 2e-16
Identities = 68/245 (27%), Positives = 115/245 (46%), Gaps = 30/245 (12%)
Query: 56 NLPLNRGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPME 115
N + + L + EE NS L+LS R + P + +L+ + L N+L +P E
Sbjct: 87 NAEVIKELNKCREE--NSMRLDLSKRSIHILPSSIK---ELTQLTELYLYSNKLQSLPAE 141
Query: 116 LCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGL---------- 165
+ V+L L L N + +P+++ NL+ L L+L N+L +P+ + L
Sbjct: 142 VGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRF 201
Query: 166 --------------PLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLK 211
L +L NK+ LP EIG+L L+ LDV+ N++ LP++IG
Sbjct: 202 NRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCT 261
Query: 212 SLRELNVRRNYLKVLPQELVDL-PLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQS 270
+ L+++ N L LP + +L L + N++ IP + L+ L LENN + +
Sbjct: 262 QITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIST 321
Query: 271 PPAQI 275
P +
Sbjct: 322 LPESL 326
Score = 82.8 bits (203), Expect = 1e-15
Identities = 62/196 (31%), Positives = 102/196 (52%), Gaps = 7/196 (3%)
Query: 103 DLSKNRLVEVPMELCHFVS-LEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPAC 161
++ NR+ ++P + L LN+ N + +P + LNL+ NQL+ +P
Sbjct: 361 NMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPED 420
Query: 162 LCGL-PLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRR 220
+ GL L+VLI SNN L LP +G L++L ELD+ N++ +LP +I LK L++L +
Sbjct: 421 VSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTN 480
Query: 221 NYLKVLPQELVDLP-LVKFDFSCNKVLVIPICFREMKQLQVLLLENNP-LQSPPAQICTK 278
N L LP+ + L L N + +P ++ L+ L L +NP L S P ++
Sbjct: 481 NQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALC 540
Query: 279 GKVHIFKYLSIQACQI 294
K+ I +SI+ C +
Sbjct: 541 SKLSI---MSIENCPL 553
Score = 82.0 bits (201), Expect = 2e-15
Identities = 65/202 (32%), Positives = 95/202 (47%), Gaps = 5/202 (2%)
Query: 76 LNLSARKLKEFPRTAAPGH--DLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIR 133
+NL L E T+ P +L DL N+L E+P + SL L L N I
Sbjct: 146 VNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRIT 205
Query: 134 VIPEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLME 192
+ + I NL L+ L++ N++ LPA + L L L ++N+L LP+EIG Q+
Sbjct: 206 TVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITN 265
Query: 193 LDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVKFDFSCNKVLVIP-I 250
LD+ NE+ LP IG L SL L +R N L +P+ L L + + N + +P
Sbjct: 266 LDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPES 325
Query: 251 CFREMKQLQVLLLENNPLQSPP 272
+ +L L L N Q P
Sbjct: 326 LLSSLVKLNSLTLARNCFQLYP 347
Score = 75.1 bits (183), Expect = 2e-13
Identities = 61/238 (25%), Positives = 110/238 (46%), Gaps = 31/238 (13%)
Query: 63 LERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSL 122
+E+ ++ + L++ K+K+ P +L + + D++ N+L +P E+ + +
Sbjct: 207 VEKDIKNLSKLSMLSIRENKIKQLPAEIG---ELCNLITLDVAHNQLEHLPKEIGNCTQI 263
Query: 123 EILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLP 181
L+L HN + +P+ I NL L+ L L N+LSA+P L L+ L NN + +LP
Sbjct: 264 TNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLP 323
Query: 182 EEI-------------------------GQLKQLMELDVSCNEITALPQQI-GQLKSLRE 215
E + Q + L++ N I +P I + K L +
Sbjct: 324 ESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSK 383
Query: 216 LNVRRNYLKVLPQEL-VDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPP 272
LN++ N L LP + +V+ + + N++ IP + L+VL+L NN L+ P
Sbjct: 384 LNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLP 441
Score = 70.9 bits (172), Expect = 4e-12
Identities = 55/178 (30%), Positives = 89/178 (50%), Gaps = 4/178 (2%)
Query: 105 SKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACL-C 163
S N V + C + L+L I ++P +I L LT L L N+L +LPA + C
Sbjct: 85 SSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGC 144
Query: 164 GLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYL 223
+ L L S N L SLP+ + LK+L LD+ N++ +P + +L SL L +R N +
Sbjct: 145 LVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRI 204
Query: 224 KVLPQELVDL-PLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI--CTK 278
+ +++ +L L NK+ +P E+ L L + +N L+ P +I CT+
Sbjct: 205 TTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQ 262
Score = 43.5 bits (101), Expect = 7e-04
Identities = 43/131 (32%), Positives = 58/131 (44%), Gaps = 13/131 (9%)
Query: 57 LPLNRGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMEL 116
LP G R L E L+L KL+ P A DL V L+ N+L +P +
Sbjct: 440 LPHGLGNLRKLRE------LDLEENKLESLPNEIAYLKDLQKLV---LTNNQLTTLPRGI 490
Query: 117 CHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRN-QLSALP--ACLCGLPLKVLIAS 173
H +L L L N + +PE I L+ L L L+ N L +LP LC L ++
Sbjct: 491 GHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCS-KLSIMSIE 549
Query: 174 NNKLGSLPEEI 184
N L LP +I
Sbjct: 550 NCPLSHLPPQI 560
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 92.8 bits (229), Expect = 1e-18
Identities = 63/175 (36%), Positives = 94/175 (53%), Gaps = 5/175 (2%)
Query: 96 LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQL 155
L+ DLS N L +P + L L L HNC+ +PEA+ L LT+L ++ N+L
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
Query: 156 SALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLR 214
LP L L L+ L S N L +LP EIG L L+EL+++ N + +LP + L+SLR
Sbjct: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
Query: 215 ELNVRRNYLKVLPQELVDLPLV-KFDFSCNKVLVIPICFREMKQLQVLLLENNPL 268
L + N L +P +L LPL+ + D N++ +P E+ + L+ NPL
Sbjct: 244 LLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP---PELLDAPFVRLQGNPL 295
Score = 63.9 bits (154), Expect = 5e-10
Identities = 47/142 (33%), Positives = 67/142 (47%), Gaps = 23/142 (16%)
Query: 135 IPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMEL 193
+P + L L +L+LS N L LPAC+ + L L+ S+N L LPE +G L L L
Sbjct: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
Query: 194 DVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFR 253
V+ N + LP +G L +L+ L++ +N L LP E+ L
Sbjct: 177 TVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLG------------------- 217
Query: 254 EMKQLQVLLLENNPLQSPPAQI 275
L L L +N LQS PA +
Sbjct: 218 ---SLLELNLASNRLQSLPASL 236
Score = 47.4 bits (111), Expect = 5e-05
Identities = 47/168 (27%), Positives = 74/168 (44%), Gaps = 23/168 (13%)
Query: 127 LYHNCIRVIPEAIVNLQMLTYLNLSRNQ--------LSALP---ACLCGLPLK------- 168
L H C+ + + L + +L LS ++ L+ LP +CL L LK
Sbjct: 50 LLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDT 105
Query: 169 VLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQ 228
+ L +LP + L L LD+S N + LP + Q++ L L + N L LP+
Sbjct: 106 LGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPE 165
Query: 229 ELVDLPLVKF-DFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
L LP + F + N++ +P + LQ L L N L + P +I
Sbjct: 166 ALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEI 213
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 92.8 bits (229), Expect = 1e-18
Identities = 63/175 (36%), Positives = 94/175 (53%), Gaps = 5/175 (2%)
Query: 96 LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQL 155
L+ DLS N L +P + L L L HNC+ +PEA+ L LT+L ++ N+L
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
Query: 156 SALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLR 214
LP L L L+ L S N L +LP EIG L L+EL+++ N + +LP + L+SLR
Sbjct: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
Query: 215 ELNVRRNYLKVLPQELVDLPLV-KFDFSCNKVLVIPICFREMKQLQVLLLENNPL 268
L + N L +P +L LPL+ + D N++ +P E+ + L+ NPL
Sbjct: 244 LLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP---PELLDAPFVRLQGNPL 295
Score = 63.9 bits (154), Expect = 5e-10
Identities = 47/142 (33%), Positives = 67/142 (47%), Gaps = 23/142 (16%)
Query: 135 IPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMEL 193
+P + L L +L+LS N L LPAC+ + L L+ S+N L LPE +G L L L
Sbjct: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
Query: 194 DVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFR 253
V+ N + LP +G L +L+ L++ +N L LP E+ L
Sbjct: 177 TVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLG------------------- 217
Query: 254 EMKQLQVLLLENNPLQSPPAQI 275
L L L +N LQS PA +
Sbjct: 218 ---SLLELNLASNRLQSLPASL 236
Score = 47.4 bits (111), Expect = 5e-05
Identities = 47/168 (27%), Positives = 74/168 (44%), Gaps = 23/168 (13%)
Query: 127 LYHNCIRVIPEAIVNLQMLTYLNLSRNQ--------LSALP---ACLCGLPLK------- 168
L H C+ + + L + +L LS ++ L+ LP +CL L LK
Sbjct: 50 LLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDT 105
Query: 169 VLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQ 228
+ L +LP + L L LD+S N + LP + Q++ L L + N L LP+
Sbjct: 106 LGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPE 165
Query: 229 ELVDLPLVKF-DFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
L LP + F + N++ +P + LQ L L N L + P +I
Sbjct: 166 ALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEI 213
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 89.7 bits (221), Expect = 8e-18
Identities = 74/239 (30%), Positives = 114/239 (47%), Gaps = 5/239 (2%)
Query: 61 RGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV 120
R L + N L LS +++ P A + V+ D+S+N + E+P +
Sbjct: 49 RELPKPFFRLLNLRKLGLSDNEIQRLPPEVA---NFMQLVELDVSRNDIPEIPESIKFCK 105
Query: 121 SLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGS 179
+LEI + N + +P+ L+ L +L L+ L ALP + L L L N L S
Sbjct: 106 ALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKS 165
Query: 180 LPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVKF 238
LP + L +L +LD+ N++ LP +G L +LREL + RN L LP EL +L LV
Sbjct: 166 LPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCL 225
Query: 239 DFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTA 297
D S N++ +P + L LLL N L+ P I ++ I K + C++ A
Sbjct: 226 DVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEA 284
Score = 86.3 bits (212), Expect = 9e-17
Identities = 76/234 (32%), Positives = 116/234 (49%), Gaps = 7/234 (2%)
Query: 77 NLSARKLKEFPRTAAPGH--DLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRV 134
+L+ L + A PG +L++ V +L +N L +P L V LE L+L N + V
Sbjct: 129 SLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEV 188
Query: 135 IPEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLMEL 193
+P+ + L L L L RNQLSALP L L L L S N+L LP E+G L L +L
Sbjct: 189 LPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDL 248
Query: 194 DVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLP-LVKFDFSCNKVLVIPICF 252
+S N + LP IGQLK L L V +N L + + + D L + + N ++ +P
Sbjct: 249 LLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSL 308
Query: 253 REMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTME 306
++ +L L ++ N L++ P +I G LS++ ++ HT E
Sbjct: 309 GKLTKLTNLNVDRNHLEALPPEI---GGCVALSVLSLRDNRLAVLPPELAHTTE 359
Score = 84.7 bits (208), Expect = 3e-16
Identities = 79/227 (34%), Positives = 105/227 (46%), Gaps = 28/227 (12%)
Query: 71 ANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHN 130
AN L L LK P + + L Q DL N L +P L +L L L N
Sbjct: 151 ANLVTLELRENLLKSLPASLS---FLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRN 207
Query: 131 CIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKV-LIASNNKLGSLPEEIGQLKQ 189
+ +P + NL+ L L++S N+L LPA L GL L L+ S N L LP+ IGQLKQ
Sbjct: 208 QLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQ 267
Query: 190 LMELDVSCN---EIT--------------------ALPQQIGQLKSLRELNVRRNYLKVL 226
L L V N E+T ALP+ +G+L L LNV RN+L+ L
Sbjct: 268 LSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEAL 327
Query: 227 PQELVD-LPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPP 272
P E+ + L N++ V+P +L VL + N LQS P
Sbjct: 328 PPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374
Score = 77.4 bits (189), Expect = 4e-14
Identities = 55/175 (31%), Positives = 86/175 (49%), Gaps = 4/175 (2%)
Query: 104 LSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACL- 162
L N+L E+P ++L L L N I+ +P + N L L++SRN + +P +
Sbjct: 43 LDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIK 102
Query: 163 -CGLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRN 221
C L++ S N L LP+ QL+ L L ++ + ALP +G L +L L +R N
Sbjct: 103 FC-KALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELREN 161
Query: 222 YLKVLPQELVDL-PLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
LK LP L L L + D N + V+P + L+ L L+ N L + P ++
Sbjct: 162 LLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPEL 216
Score = 60.5 bits (145), Expect = 5e-09
Identities = 53/161 (32%), Positives = 76/161 (47%), Gaps = 4/161 (2%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
L++S +L+E P L+D + LS+N L +P + L IL + N + +
Sbjct: 225 LDVSENRLEELPAELGGLVLLTDLL---LSQNLLRRLPDGIGQLKQLSILKVDQNRLCEV 281
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMELD 194
EAI + + L+ L L+ N L ALP L L L L N L +LP EIG L L
Sbjct: 282 TEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLS 341
Query: 195 VSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPL 235
+ N + LP ++ L L+V N L+ LP L L L
Sbjct: 342 LRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNL 382
Score = 57.0 bits (136), Expect = 6e-08
Identities = 51/167 (30%), Positives = 78/167 (46%), Gaps = 4/167 (2%)
Query: 112 VPMELCHFVSLEILNLYHNCIRVIPEAIVNL-QMLTYLNLSRNQLSALPACLCGL-PLKV 169
+P+ C+ +E ++ H ++ +PE I + L L L NQL LP L L+
Sbjct: 5 IPLWRCNR-HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRK 63
Query: 170 LIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQE 229
L S+N++ LP E+ QL+ELDVS N+I +P+ I K+L + N L LP
Sbjct: 64 LGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDG 123
Query: 230 LVDL-PLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
L L + + +P + L L L N L+S PA +
Sbjct: 124 FTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
Score = 45.8 bits (107), Expect = 1e-04
Identities = 31/111 (27%), Positives = 55/111 (49%), Gaps = 3/111 (2%)
Query: 66 ALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEIL 125
A+ + N L L+ L PR+ L+ ++ +N L +P E+ V+L +L
Sbjct: 284 AIGDCENLSELILTENLLMALPRSLGK---LTKLTNLNVDRNHLEALPPEIGGCVALSVL 340
Query: 126 NLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNK 176
+L N + V+P + + L L+++ N+L +LP L L LK L + N+
Sbjct: 341 SLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQ 391
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 89.7 bits (221), Expect = 8e-18
Identities = 74/239 (30%), Positives = 114/239 (47%), Gaps = 5/239 (2%)
Query: 61 RGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV 120
R L + N L LS +++ P A + V+ D+S+N + E+P +
Sbjct: 49 RELPKPFFRLLNLRKLGLSDNEIQRLPPEVA---NFMQLVELDVSRNDIPEIPESIKFCK 105
Query: 121 SLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGS 179
+LEI + N + +P+ L+ L +L L+ L ALP + L L L N L S
Sbjct: 106 ALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKS 165
Query: 180 LPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVKF 238
LP + L +L +LD+ N++ LP +G L +LREL + RN L LP EL +L LV
Sbjct: 166 LPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCL 225
Query: 239 DFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTA 297
D S N++ +P + L LLL N L+ P I ++ I K + C++ A
Sbjct: 226 DVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEA 284
Score = 86.3 bits (212), Expect = 9e-17
Identities = 76/234 (32%), Positives = 116/234 (49%), Gaps = 7/234 (2%)
Query: 77 NLSARKLKEFPRTAAPGH--DLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRV 134
+L+ L + A PG +L++ V +L +N L +P L V LE L+L N + V
Sbjct: 129 SLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEV 188
Query: 135 IPEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLMEL 193
+P+ + L L L L RNQLSALP L L L L S N+L LP E+G L L +L
Sbjct: 189 LPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDL 248
Query: 194 DVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLP-LVKFDFSCNKVLVIPICF 252
+S N + LP IGQLK L L V +N L + + + D L + + N ++ +P
Sbjct: 249 LLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSL 308
Query: 253 REMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTME 306
++ +L L ++ N L++ P +I G LS++ ++ HT E
Sbjct: 309 GKLTKLTNLNVDRNHLEALPPEI---GGCVALSVLSLRDNRLAVLPPELAHTTE 359
Score = 84.7 bits (208), Expect = 3e-16
Identities = 79/227 (34%), Positives = 105/227 (46%), Gaps = 28/227 (12%)
Query: 71 ANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHN 130
AN L L LK P + + L Q DL N L +P L +L L L N
Sbjct: 151 ANLVTLELRENLLKSLPASLS---FLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRN 207
Query: 131 CIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKV-LIASNNKLGSLPEEIGQLKQ 189
+ +P + NL+ L L++S N+L LPA L GL L L+ S N L LP+ IGQLKQ
Sbjct: 208 QLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQ 267
Query: 190 LMELDVSCN---EIT--------------------ALPQQIGQLKSLRELNVRRNYLKVL 226
L L V N E+T ALP+ +G+L L LNV RN+L+ L
Sbjct: 268 LSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEAL 327
Query: 227 PQELVD-LPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPP 272
P E+ + L N++ V+P +L VL + N LQS P
Sbjct: 328 PPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374
Score = 77.4 bits (189), Expect = 4e-14
Identities = 55/175 (31%), Positives = 86/175 (49%), Gaps = 4/175 (2%)
Query: 104 LSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACL- 162
L N+L E+P ++L L L N I+ +P + N L L++SRN + +P +
Sbjct: 43 LDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIK 102
Query: 163 -CGLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRN 221
C L++ S N L LP+ QL+ L L ++ + ALP +G L +L L +R N
Sbjct: 103 FC-KALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELREN 161
Query: 222 YLKVLPQELVDL-PLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
LK LP L L L + D N + V+P + L+ L L+ N L + P ++
Sbjct: 162 LLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPEL 216
Score = 60.5 bits (145), Expect = 5e-09
Identities = 53/161 (32%), Positives = 76/161 (47%), Gaps = 4/161 (2%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
L++S +L+E P L+D + LS+N L +P + L IL + N + +
Sbjct: 225 LDVSENRLEELPAELGGLVLLTDLL---LSQNLLRRLPDGIGQLKQLSILKVDQNRLCEV 281
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMELD 194
EAI + + L+ L L+ N L ALP L L L L N L +LP EIG L L
Sbjct: 282 TEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLS 341
Query: 195 VSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPL 235
+ N + LP ++ L L+V N L+ LP L L L
Sbjct: 342 LRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNL 382
Score = 57.0 bits (136), Expect = 6e-08
Identities = 51/167 (30%), Positives = 78/167 (46%), Gaps = 4/167 (2%)
Query: 112 VPMELCHFVSLEILNLYHNCIRVIPEAIVNL-QMLTYLNLSRNQLSALPACLCGL-PLKV 169
+P+ C+ +E ++ H ++ +PE I + L L L NQL LP L L+
Sbjct: 5 IPLWRCNR-HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRK 63
Query: 170 LIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQE 229
L S+N++ LP E+ QL+ELDVS N+I +P+ I K+L + N L LP
Sbjct: 64 LGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDG 123
Query: 230 LVDL-PLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
L L + + +P + L L L N L+S PA +
Sbjct: 124 FTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
Score = 45.8 bits (107), Expect = 1e-04
Identities = 31/111 (27%), Positives = 55/111 (49%), Gaps = 3/111 (2%)
Query: 66 ALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEIL 125
A+ + N L L+ L PR+ L+ ++ +N L +P E+ V+L +L
Sbjct: 284 AIGDCENLSELILTENLLMALPRSLGK---LTKLTNLNVDRNHLEALPPEIGGCVALSVL 340
Query: 126 NLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNK 176
+L N + V+P + + L L+++ N+L +LP L L LK L + N+
Sbjct: 341 SLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQ 391
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 89.4 bits (220), Expect = 1e-17
Identities = 65/194 (33%), Positives = 102/194 (52%), Gaps = 3/194 (1%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV-SLEILNLYHNCIRV 134
L L+ R L FP L + + +N L +P L + +L L L+ N I V
Sbjct: 20 LFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV 79
Query: 135 IPEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLMEL 193
+PEAI +L L L+LS N L + + L L+ L +NN+L LP E+G LK+L L
Sbjct: 80 VPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTL 139
Query: 194 DVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLP-LVKFDFSCNKVLVIPICF 252
D+S N + LP+++ SL+ L V RN L +P+ L LP L + + N++ +P+
Sbjct: 140 DISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDL 199
Query: 253 REMKQLQVLLLENN 266
++LQ + ++NN
Sbjct: 200 GRSRELQYVYVDNN 213
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 87.8 bits (216), Expect = 3e-17
Identities = 73/222 (32%), Positives = 107/222 (48%), Gaps = 28/222 (12%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
L L +LK P+T + L+ + DL N EVP L L+ + N + I
Sbjct: 166 LELRENQLKMLPKTM---NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFI 222
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLK------ 188
P I +L+ LTYL++S+N + + + L+ L+ S+N L LPE IG LK
Sbjct: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK 282
Query: 189 ----QLM-------------ELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELV 231
QLM ELD S NE+ ALP IGQL +LR NYL+ LP E+
Sbjct: 283 IDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIG 342
Query: 232 DLPLVKFDF-SCNKVLVIPICFREMKQLQVLLLENNPLQSPP 272
+ F NK+ +P +M++L+V+ L +N L++ P
Sbjct: 343 SWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 78.2 bits (191), Expect = 3e-14
Identities = 70/237 (29%), Positives = 107/237 (45%), Gaps = 34/237 (14%)
Query: 64 ERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLE 123
E+ LEE L L A +++E P+ L + L N L +P + + ++L
Sbjct: 45 EKTLEE------LYLDANQIEELPKQLFNCQSLH---KLSLPDNDLTTLPASIANLINLR 95
Query: 124 ILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALP----------------ACLCGLP- 166
L++ N I+ PE I N ++LT + S N +S LP A L LP
Sbjct: 96 ELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPA 155
Query: 167 -------LKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVR 219
L++L N+L LP+ + +L QL LD+ NE T +P+ + QL L+E +
Sbjct: 156 NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMD 215
Query: 220 RNYLKVLPQELVDL-PLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
N L +P + L L D S N + ++ + LQ LLL +N LQ P I
Sbjct: 216 ANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272
Score = 62.0 bits (149), Expect = 2e-09
Identities = 53/212 (25%), Positives = 98/212 (46%), Gaps = 12/212 (5%)
Query: 63 LERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSL 122
+E + N L LS+ L++ P T L + + +N+L+ +P + +S+
Sbjct: 245 VEEGISTCENLQDLLLSSNSLQQLPETIG---SLKNITTLKIDENQLMYLPDSIGGLISV 301
Query: 123 EILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLP 181
E L+ N + +P +I L L N L LP + + VL +NKL +LP
Sbjct: 302 EELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLP 361
Query: 182 EEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVK-FDF 240
EE+G +++L +++S N + LP +L+ L + + N K L +PL K D
Sbjct: 362 EEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL------IPLQKETDS 415
Query: 241 SCNKVLVIPICFREMKQLQ-VLLLENNPLQSP 271
K+++ F + + + V+ + +N +P
Sbjct: 416 ETQKMVLTNYMFPQQPRTEDVMFISDNESFNP 447
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 87.8 bits (216), Expect = 3e-17
Identities = 73/222 (32%), Positives = 107/222 (48%), Gaps = 28/222 (12%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
L L +LK P+T + L+ + DL N EVP L L+ + N + I
Sbjct: 166 LELRENQLKMLPKTM---NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFI 222
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLK------ 188
P I +L+ LTYL++S+N + + + L+ L+ S+N L LPE IG LK
Sbjct: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK 282
Query: 189 ----QLM-------------ELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELV 231
QLM ELD S NE+ ALP IGQL +LR NYL+ LP E+
Sbjct: 283 IDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIG 342
Query: 232 DLPLVKFDF-SCNKVLVIPICFREMKQLQVLLLENNPLQSPP 272
+ F NK+ +P +M++L+V+ L +N L++ P
Sbjct: 343 SWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 78.2 bits (191), Expect = 3e-14
Identities = 70/237 (29%), Positives = 107/237 (45%), Gaps = 34/237 (14%)
Query: 64 ERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLE 123
E+ LEE L L A +++E P+ L + L N L +P + + ++L
Sbjct: 45 EKTLEE------LYLDANQIEELPKQLFNCQSLH---KLSLPDNDLTTLPASIANLINLR 95
Query: 124 ILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALP----------------ACLCGLP- 166
L++ N I+ PE I N ++LT + S N +S LP A L LP
Sbjct: 96 ELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPA 155
Query: 167 -------LKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVR 219
L++L N+L LP+ + +L QL LD+ NE T +P+ + QL L+E +
Sbjct: 156 NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMD 215
Query: 220 RNYLKVLPQELVDL-PLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
N L +P + L L D S N + ++ + LQ LLL +N LQ P I
Sbjct: 216 ANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272
Score = 62.0 bits (149), Expect = 2e-09
Identities = 53/212 (25%), Positives = 98/212 (46%), Gaps = 12/212 (5%)
Query: 63 LERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSL 122
+E + N L LS+ L++ P T L + + +N+L+ +P + +S+
Sbjct: 245 VEEGISTCENLQDLLLSSNSLQQLPETIG---SLKNITTLKIDENQLMYLPDSIGGLISV 301
Query: 123 EILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLP 181
E L+ N + +P +I L L N L LP + + VL +NKL +LP
Sbjct: 302 EELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLP 361
Query: 182 EEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVK-FDF 240
EE+G +++L +++S N + LP +L+ L + + N K L +PL K D
Sbjct: 362 EEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL------IPLQKETDS 415
Query: 241 SCNKVLVIPICFREMKQLQ-VLLLENNPLQSP 271
K+++ F + + + V+ + +N +P
Sbjct: 416 ETQKMVLTNYMFPQQPRTEDVMFISDNESFNP 447
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 87.4 bits (215), Expect = 4e-17
Identities = 67/212 (31%), Positives = 110/212 (51%), Gaps = 5/212 (2%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
L LS +++ P A + V+ D+S+N + E+P + +L++ + N + +
Sbjct: 64 LGLSDNEIQRLPPEIA---NFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRL 120
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLMELD 194
PE+ LQ LT L+++ L +LP + L L L N L LP+ + QL++L ELD
Sbjct: 121 PESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELD 180
Query: 195 VSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLP-LVKFDFSCNKVLVIPICFR 253
+ NEI LP+ IG L L++L + N L LPQE+ +L L+ D S N++ +P
Sbjct: 181 LGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEIS 240
Query: 254 EMKQLQVLLLENNPLQSPPAQICTKGKVHIFK 285
+ L L++ N L++ P I K+ I K
Sbjct: 241 GLTSLTDLVISQNLLETIPDGIGKLKKLSILK 272
Score = 84.7 bits (208), Expect = 3e-16
Identities = 67/215 (31%), Positives = 108/215 (50%), Gaps = 15/215 (6%)
Query: 65 RALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEI 124
+AL+ A SG N R + FP +L + ++ L +P + + +L
Sbjct: 105 KALQVADFSG--NPLTRLPESFP-------ELQNLTCLSVNDISLQSLPENIGNLYNLAS 155
Query: 125 LNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEE 183
L L N + +P+++ L+ L L+L N++ LP + L LK L N+L LP+E
Sbjct: 156 LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQE 215
Query: 184 IGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQ---ELVDLPLVKFDF 240
IG LK L+ LDVS N + LP++I L SL +L + +N L+ +P +L L ++K D
Sbjct: 216 IGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVD- 274
Query: 241 SCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
N++ +P E + L L+L N L + P I
Sbjct: 275 -QNRLTQLPEAVGECESLTELVLTENQLLTLPKSI 308
Score = 84.3 bits (207), Expect = 4e-16
Identities = 59/174 (33%), Positives = 91/174 (52%), Gaps = 2/174 (1%)
Query: 104 LSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLC 163
L N+L E+P E+ + +L L++ N + +PE I L LT L +S+N L +P +
Sbjct: 204 LDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIG 263
Query: 164 GLP-LKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNY 222
L L +L N+L LPE +G+ + L EL ++ N++ LP+ IG+LK L LN RN
Sbjct: 264 KLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNK 323
Query: 223 LKVLPQELVD-LPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
L LP+E+ L F N++ IP + +L VL + N L P +
Sbjct: 324 LVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377
Score = 81.6 bits (200), Expect = 2e-15
Identities = 57/174 (32%), Positives = 85/174 (48%), Gaps = 2/174 (1%)
Query: 104 LSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLC 163
L N+L E+P + V L L L N I+ +P I N L L++SRN++ +P +
Sbjct: 43 LDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESIS 102
Query: 164 GL-PLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNY 222
L+V S N L LPE +L+ L L V+ + +LP+ IG L +L L +R N
Sbjct: 103 FCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENL 162
Query: 223 LKVLPQELVDL-PLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
L LP L L L + D N++ +P + L+ L L+ N L P +I
Sbjct: 163 LTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 216
Score = 73.6 bits (179), Expect = 6e-13
Identities = 58/170 (34%), Positives = 82/170 (48%), Gaps = 4/170 (2%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
L++S +L+ P + L+D V +S+N L +P + L IL + N + +
Sbjct: 225 LDVSENRLERLPEEISGLTSLTDLV---ISQNLLETIPDGIGKLKKLSILKVDQNRLTQL 281
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMELD 194
PEA+ + LT L L+ NQL LP + L L L A NKL SLP+EIG L
Sbjct: 282 PEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFC 341
Query: 195 VSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNK 244
V N +T +P ++ Q L L+V N L LP L L L S N+
Sbjct: 342 VRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLKALWLSDNQ 391
Score = 57.8 bits (138), Expect = 4e-08
Identities = 53/190 (27%), Positives = 84/190 (44%), Gaps = 27/190 (14%)
Query: 112 VPMELCHFVSLEILNLYHNCIRVIPEAIVNL-QMLTYLNLSRNQLSALPACLCGL-PLKV 169
+P+ C+ +E ++ H + +PE I + L L L NQL LP L L+
Sbjct: 5 IPLWRCNR-HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRK 63
Query: 170 LIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQE 229
L S+N++ LP EI QL+ELDVS NEI +P+ I K+L+ + N L LP+
Sbjct: 64 LGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPES 123
Query: 230 LVDLP------------------------LVKFDFSCNKVLVIPICFREMKQLQVLLLEN 265
+L L + N + +P ++++L+ L L N
Sbjct: 124 FPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGN 183
Query: 266 NPLQSPPAQI 275
N + + P I
Sbjct: 184 NEIYNLPESI 193
>gi|53729363 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 86.3 bits (212), Expect = 9e-17
Identities = 100/428 (23%), Positives = 185/428 (43%), Gaps = 42/428 (9%)
Query: 80 ARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPM---ELCHFVSLEILNLYHNCIR-VI 135
ARK E+ A D + D+SK L E+P C + ++L ++ N + ++
Sbjct: 14 ARKRLEYQMCLAKEAGADDIL--DISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLL 71
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDV 195
P++ L + T +KVL +N+L +LP+++GQL L L+V
Sbjct: 72 PKSCSLLSLAT--------------------IKVLDLHDNQLTALPDDLGQLTALQVLNV 111
Query: 196 SCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVKFDFSCNKVLVIPICFRE 254
N++ LP+ IG L L+ LNV+ N LK LP + +L L + S N++ +P
Sbjct: 112 ERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAH 171
Query: 255 MKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQHV 314
++ L++L L+ + + PP ++C G I ++L ++ S YL P L Q
Sbjct: 172 VRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYL----LPILEQDG 227
Query: 315 EDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQIIKEDSCHRLSPVKG 374
+ +DS D R S E ++ S E++ + K + RL +
Sbjct: 228 IENSRDS-----PDGPTDRFSREELEWQNRFS---DYEKRKEQKMLEKLEFERRLELGQR 279
Query: 375 EFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAEDCEELLRIEEDVHWQ 434
E Q Q S + + +E ++ H +N + R E+L + E+++ +
Sbjct: 280 EHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAE-RQRLQEQLKQTEQNISSR 338
Query: 435 TEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNLYPMGSAEALELQDS 494
+ ++ ++ Q +++ L ++ ++ + TE L + SA L +S
Sbjct: 339 IQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETES--LRRRDVASAMQQMLTES 396
Query: 495 ALNGQIQL 502
N IQ+
Sbjct: 397 CKNRLIQM 404
>gi|53729361 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 86.3 bits (212), Expect = 9e-17
Identities = 100/428 (23%), Positives = 185/428 (43%), Gaps = 42/428 (9%)
Query: 80 ARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPM---ELCHFVSLEILNLYHNCIR-VI 135
ARK E+ A D + D+SK L E+P C + ++L ++ N + ++
Sbjct: 14 ARKRLEYQMCLAKEAGADDIL--DISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLL 71
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDV 195
P++ L + T +KVL +N+L +LP+++GQL L L+V
Sbjct: 72 PKSCSLLSLAT--------------------IKVLDLHDNQLTALPDDLGQLTALQVLNV 111
Query: 196 SCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVKFDFSCNKVLVIPICFRE 254
N++ LP+ IG L L+ LNV+ N LK LP + +L L + S N++ +P
Sbjct: 112 ERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAH 171
Query: 255 MKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQHV 314
++ L++L L+ + + PP ++C G I ++L ++ S YL P L Q
Sbjct: 172 VRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYL----LPILEQDG 227
Query: 315 EDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQIIKEDSCHRLSPVKG 374
+ +DS D R S E ++ S E++ + K + RL +
Sbjct: 228 IENSRDS-----PDGPTDRFSREELEWQNRFS---DYEKRKEQKMLEKLEFERRLELGQR 279
Query: 375 EFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAEDCEELLRIEEDVHWQ 434
E Q Q S + + +E ++ H +N + R E+L + E+++ +
Sbjct: 280 EHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAE-RQRLQEQLKQTEQNISSR 338
Query: 435 TEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNLYPMGSAEALELQDS 494
+ ++ ++ Q +++ L ++ ++ + TE L + SA L +S
Sbjct: 339 IQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETES--LRRRDVASAMQQMLTES 396
Query: 495 ALNGQIQL 502
N IQ+
Sbjct: 397 CKNRLIQM 404
>gi|53729359 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 86.3 bits (212), Expect = 9e-17
Identities = 100/428 (23%), Positives = 185/428 (43%), Gaps = 42/428 (9%)
Query: 80 ARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPM---ELCHFVSLEILNLYHNCIR-VI 135
ARK E+ A D + D+SK L E+P C + ++L ++ N + ++
Sbjct: 14 ARKRLEYQMCLAKEAGADDIL--DISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLL 71
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDV 195
P++ L + T +KVL +N+L +LP+++GQL L L+V
Sbjct: 72 PKSCSLLSLAT--------------------IKVLDLHDNQLTALPDDLGQLTALQVLNV 111
Query: 196 SCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVKFDFSCNKVLVIPICFRE 254
N++ LP+ IG L L+ LNV+ N LK LP + +L L + S N++ +P
Sbjct: 112 ERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAH 171
Query: 255 MKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQHV 314
++ L++L L+ + + PP ++C G I ++L ++ S YL P L Q
Sbjct: 172 VRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYL----LPILEQDG 227
Query: 315 EDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQIIKEDSCHRLSPVKG 374
+ +DS D R S E ++ S E++ + K + RL +
Sbjct: 228 IENSRDS-----PDGPTDRFSREELEWQNRFS---DYEKRKEQKMLEKLEFERRLELGQR 279
Query: 375 EFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAEDCEELLRIEEDVHWQ 434
E Q Q S + + +E ++ H +N + R E+L + E+++ +
Sbjct: 280 EHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAE-RQRLQEQLKQTEQNISSR 338
Query: 435 TEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNLYPMGSAEALELQDS 494
+ ++ ++ Q +++ L ++ ++ + TE L + SA L +S
Sbjct: 339 IQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETES--LRRRDVASAMQQMLTES 396
Query: 495 ALNGQIQL 502
N IQ+
Sbjct: 397 CKNRLIQM 404
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 85.5 bits (210), Expect = 2e-16
Identities = 56/149 (37%), Positives = 84/149 (56%), Gaps = 5/149 (3%)
Query: 122 LEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSL 180
L L L HNC+ +PEA+ L LT+L ++ N+L LP L L L+ L S N L +L
Sbjct: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
Query: 181 PEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLV-KFD 239
P EIG L L+EL+++ N + +LP + L+SLR L + N L +P +L LPL+ + D
Sbjct: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
Query: 240 FSCNKVLVIPICFREMKQLQVLLLENNPL 268
N++ +P E+ + L+ NPL
Sbjct: 124 LRDNQLRDLP---PELLDAPFVRLQGNPL 149
Score = 64.7 bits (156), Expect = 3e-10
Identities = 45/135 (33%), Positives = 69/135 (51%), Gaps = 4/135 (2%)
Query: 74 GGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIR 133
G L LS L E P L ++ NRL +P L +L+ L+L N +
Sbjct: 5 GALLLSHNCLSELPEALGA---LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
Query: 134 VIPEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLME 192
+P I L L LNL+ N+L +LPA L GL L++L+ +N L S+P ++ +L L
Sbjct: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
Query: 193 LDVSCNEITALPQQI 207
LD+ N++ LP ++
Sbjct: 122 LDLRDNQLRDLPPEL 136
Score = 44.7 bits (104), Expect = 3e-04
Identities = 29/83 (34%), Positives = 41/83 (49%), Gaps = 2/83 (2%)
Query: 96 LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQL 155
L ++ +L+ NRL +P L SL +L L+ N + +P + L +LT L+L NQL
Sbjct: 70 LGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 129
Query: 156 SALPACLCGLPLKVLIASNNKLG 178
LP L P L N LG
Sbjct: 130 RDLPPELLDAPFVRL--QGNPLG 150
Score = 38.5 bits (88), Expect = 0.022
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 1/90 (1%)
Query: 187 LKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVKFDFSCNKV 245
++ L L +S N ++ LP+ +G L +L L V N L+ LP L L L + D S N +
Sbjct: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
Query: 246 LVIPICFREMKQLQVLLLENNPLQSPPAQI 275
+P + L L L +N LQS PA +
Sbjct: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASL 90
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 83.6 bits (205), Expect = 6e-16
Identities = 78/309 (25%), Positives = 127/309 (41%), Gaps = 100/309 (32%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
++L K+ P GH L+ + ++ N L +P LC L +L+L HN + I
Sbjct: 193 IDLDENKIGAIPEEI--GH-LTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSI 249
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLC-------------GL----------------- 165
P++ L+ +T + LS N+L +P +C GL
Sbjct: 250 PKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLD 309
Query: 166 -----------------PLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNE--------- 199
L+VL +NK+G LP E+G L +L L ++ NE
Sbjct: 310 LSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVL 369
Query: 200 -----------------ITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLP-LVKFDFS 241
+T +P+ I +L+SL+EL + N+L+ LP L +P L D
Sbjct: 370 SLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCR 429
Query: 242 CNKVLVIP--IC----FREMK-----------------QLQVLLLENNPLQSPPAQICTK 278
N + +P IC +E++ L+VL L +NP++ PP ++C +
Sbjct: 430 HNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAE 489
Query: 279 GKVHIFKYL 287
G I+KYL
Sbjct: 490 GNEAIWKYL 498
Score = 77.0 bits (188), Expect = 6e-14
Identities = 59/199 (29%), Positives = 93/199 (46%), Gaps = 26/199 (13%)
Query: 104 LSKNRLVEVPMELC-HFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACL 162
L + L E+P+ + + LE+L L N ++ +P+ IVN L + L RNQ P L
Sbjct: 125 LYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQEL 184
Query: 163 CGL-PLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRN 221
C L L+++ NK+G++PEEIG L L + ++ N + LP + Q L L++ N
Sbjct: 185 CVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHN 244
Query: 222 YLKVLPQELVDL-PLVKFDFSCNKVLVIP--IC---------------------FREMKQ 257
L +P+ +L + + S N++ +P IC FR +
Sbjct: 245 LLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVN 304
Query: 258 LQVLLLENNPLQSPPAQIC 276
L+ L L N L P QIC
Sbjct: 305 LRFLDLSQNHLHHCPLQIC 323
Score = 65.5 bits (158), Expect = 2e-10
Identities = 63/212 (29%), Positives = 91/212 (42%), Gaps = 27/212 (12%)
Query: 92 PGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLS 151
P H T D S L +P+E+ F LE ++L +N I IP+ I L+ + L L
Sbjct: 20 PQHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLD 79
Query: 152 RNQLSAL-PACLCGLPLKVLIASNNKLGS------------------------LPEEI-G 185
+N L +L PA L+ L S N + S +P I
Sbjct: 80 KNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFK 139
Query: 186 QLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVKFDFSCNK 244
L L L ++ N + LP++I LRE+ ++RN +V PQEL L L D NK
Sbjct: 140 NLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENK 199
Query: 245 VLVIPICFREMKQLQVLLLENNPLQSPPAQIC 276
+ IP + LQ + +N L PA +C
Sbjct: 200 IGAIPEEIGHLTGLQKFYMASNNLPVLPASLC 231
Score = 44.7 bits (104), Expect = 3e-04
Identities = 41/161 (25%), Positives = 71/161 (44%), Gaps = 27/161 (16%)
Query: 172 ASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELV 231
ASN L ++P EI +L E+ + N+I +PQ+I +LK++R L + +N L+ L L
Sbjct: 32 ASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALG 91
Query: 232 DL-PLVKFDFSCNKVL-------------------------VIPICFREMKQLQVLLLEN 265
L L D S N + + + F+ + L++L L
Sbjct: 92 LLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTG 151
Query: 266 NPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTME 306
N L+ P +I + K+ YL ++ + L+T+E
Sbjct: 152 NHLKCLPKEIVNQTKLREI-YLKRNQFEVFPQELCVLYTLE 191
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 83.2 bits (204), Expect = 8e-16
Identities = 67/197 (34%), Positives = 98/197 (49%), Gaps = 29/197 (14%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQA-DLSKNRLVEVPMELCHFVSLEILNLYHNC-IR 133
L+LS + E P PG L +Q LS N++ VP EL + SLE L L N I
Sbjct: 111 LDLSRNTISEIP----PGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDIC 166
Query: 134 VIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLME 192
+P+ + NL LT+L+LS N + +P + +P L+ L +NKL LP+ I +++ L
Sbjct: 167 DLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHT 226
Query: 193 LDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICF 252
L + NEIT LPQ I +K+L L + S NK+ IP+C
Sbjct: 227 LWLQRNEITCLPQTISNMKNLGTLVL----------------------SNNKLQDIPVCM 264
Query: 253 REMKQLQVLLLENNPLQ 269
EM L+ + +NPL+
Sbjct: 265 EEMANLRFVNFRDNPLK 281
Score = 73.9 bits (180), Expect = 5e-13
Identities = 56/213 (26%), Positives = 100/213 (46%), Gaps = 8/213 (3%)
Query: 104 LSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLC 163
+ K +P L L+ L+ + IPE I Q L L+LSRN +S +P +
Sbjct: 67 IEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIG 126
Query: 164 GLP-LKVLIASNNKLGSLPEEIGQLKQLMELDVSCN-EITALPQQIGQLKSLRELNVRRN 221
L L+ LI S NK+ ++P+E+ L +L+++ N +I LPQ++ L L L++ N
Sbjct: 127 LLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMN 186
Query: 222 YLKVLPQELVDLPLVKF-DFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGK 280
+P ++++P +++ D NK+ +P M+ L L L+ N + P I
Sbjct: 187 DFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKN 246
Query: 281 VHIF-----KYLSIQACQIKTADSLYLHTMERP 308
+ K I C + A+ +++ + P
Sbjct: 247 LGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNP 279
Score = 52.4 bits (124), Expect = 1e-06
Identities = 46/161 (28%), Positives = 69/161 (42%), Gaps = 26/161 (16%)
Query: 148 LNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQ 206
L + + + LP+ L L L+ L +PE IG+ + L+ LD+S N I+ +P
Sbjct: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
Query: 207 IGQLKSLRELNVRRNYLKVLPQEL-----------------VDLP--------LVKFDFS 241
IG L L+EL + N +K +P+EL DLP L D S
Sbjct: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
Query: 242 CNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVH 282
N IP+ M L+ L + +N L+ P I +H
Sbjct: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLH 225
Score = 32.7 bits (73), Expect = 1.2
Identities = 25/100 (25%), Positives = 47/100 (47%), Gaps = 1/100 (1%)
Query: 177 LGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLP-L 235
L L E++ + + L + E LP + +L L+E + R L +P+ + L
Sbjct: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
Query: 236 VKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
+ D S N + IP + +LQ L+L N +++ P ++
Sbjct: 109 IVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKEL 148
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 82.8 bits (203), Expect = 1e-15
Identities = 63/214 (29%), Positives = 97/214 (45%), Gaps = 50/214 (23%)
Query: 96 LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAI-VNLQMLTYLNLSRNQ 154
L D DLS N+L E P EL + ++ +LNL HN I IP + +NL L YL+LS N+
Sbjct: 103 LDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENR 162
Query: 155 LSALPACLCGLP-LKVLIASNNKL--------------------------GSLPEEIGQL 187
L +LP + L L+ L+ + N L +LP + L
Sbjct: 163 LESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGL 222
Query: 188 KQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLV 247
L ++D+SCN++T +P+ + L SLR LN+ S N++
Sbjct: 223 SNLADVDLSCNDLTRVPECLYTLPSLRRLNL----------------------SSNQITE 260
Query: 248 IPICFREMKQLQVLLLENNPLQSPPAQICTKGKV 281
+ +C + ++ L L N L S P+ IC K+
Sbjct: 261 LSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKL 294
Score = 77.0 bits (188), Expect = 6e-14
Identities = 52/161 (32%), Positives = 87/161 (54%), Gaps = 5/161 (3%)
Query: 113 PMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLI 171
P + SL L L + +PE + LQ L +L++S N L+ L L LP L+ ++
Sbjct: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
Query: 172 ASNNKL--GSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQE 229
A N L +P++I +L L LD+S N++T P+++ K++ LN+ N + +P +
Sbjct: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQ 145
Query: 230 L-VDL-PLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPL 268
L ++L L+ D S N++ +P R + LQ L+L NPL
Sbjct: 146 LFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPL 186
Score = 76.3 bits (186), Expect = 1e-13
Identities = 58/158 (36%), Positives = 83/158 (52%), Gaps = 4/158 (2%)
Query: 96 LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQL 155
LS+ DLS N L VP L SL LNL N I + I + LNLSRNQL
Sbjct: 222 LSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQL 281
Query: 156 SALPACLCGL-PLKVLIASNNKL--GSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKS 212
++LP+ +C L LK L ++NKL LP IG+L L E + N + +P+ + +
Sbjct: 282 TSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPK 341
Query: 213 LRELNVRRNYLKVLPQELVDLPLVK-FDFSCNKVLVIP 249
LR+L + +N+L LP+ + L ++ D N LV+P
Sbjct: 342 LRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
Score = 74.7 bits (182), Expect = 3e-13
Identities = 74/221 (33%), Positives = 106/221 (47%), Gaps = 13/221 (5%)
Query: 65 RALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLE- 123
R LE A N LNLS + P +L+D + DLS+NRL +P ++ V L+
Sbjct: 121 RELENAKNMLVLNLSHNSIDTIPNQLFI--NLTDLLYLDLSENRLESLPPQMRRLVHLQT 178
Query: 124 -ILN---LYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLG 178
+LN L H +R +P A+ LQ L + R Q S LP L GL L + S N L
Sbjct: 179 LVLNGNPLLHAQLRQLP-AMTALQTLHLRSTQRTQ-SNLPTSLEGLSNLADVDLSCNDLT 236
Query: 179 SLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDL-PLVK 237
+PE + L L L++S N+IT L I Q + LN+ RN L LP + L L K
Sbjct: 237 RVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKK 296
Query: 238 FDFSCNKVLV--IPICFREMKQLQVLLLENNPLQSPPAQIC 276
+ NK+ +P ++ L+ + NN L+ P +C
Sbjct: 297 LYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLC 337
Score = 68.6 bits (166), Expect = 2e-11
Identities = 52/173 (30%), Positives = 88/173 (50%), Gaps = 6/173 (3%)
Query: 63 LERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSL 122
L +LE +N ++LS L P + L + +LS N++ E+ + + +V +
Sbjct: 215 LPTSLEGLSNLADVDLSCNDLTRVPECL---YTLPSLRRLNLSSNQITELSLCIDQWVHV 271
Query: 123 EILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLS--ALPACLCGLP-LKVLIASNNKLGS 179
E LNL N + +P AI L L L L+ N+L LP+ + L L+ +A+NN L
Sbjct: 272 ETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLEL 331
Query: 180 LPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVD 232
+PE + + +L +L ++ N + LP+ I L + L+VR N V+P + D
Sbjct: 332 VPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384
Score = 37.0 bits (84), Expect = 0.065
Identities = 29/109 (26%), Positives = 50/109 (45%), Gaps = 3/109 (2%)
Query: 170 LIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQE 229
L ++ K G PE + + L L ++ + LP+++ L+ L L+V N L L E
Sbjct: 15 LSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGE 74
Query: 230 LVDLPLVKFDFSCNKVLV---IPICFREMKQLQVLLLENNPLQSPPAQI 275
L LP ++ + L +P ++ L VL L +N L P ++
Sbjct: 75 LSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPREL 123
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 81.6 bits (200), Expect = 2e-15
Identities = 59/184 (32%), Positives = 99/184 (53%), Gaps = 4/184 (2%)
Query: 96 LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIV--NLQMLTYLNLSRN 153
+ + + +L L +P + +L+ L+L N IR I E I +L+ LT L L N
Sbjct: 634 MMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHN 693
Query: 154 QLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKS 212
++ +P + + L+ L SNNKL SLP + L++L LDVS N I+ +P +IG L++
Sbjct: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
Query: 213 LRELNVRRNYLKVLPQELVD-LPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSP 271
L+ L++ N + +LP++L + L + N + +P ++ QL L L+ N L
Sbjct: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRL 813
Query: 272 PAQI 275
PAQ+
Sbjct: 814 PAQL 817
Score = 74.3 bits (181), Expect = 4e-13
Identities = 58/198 (29%), Positives = 92/198 (46%), Gaps = 29/198 (14%)
Query: 66 ALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKN--RLVEVPMELCHFVSLE 123
+L++ N L L +L+ P LS+ + DL N R +E + H L
Sbjct: 630 SLKKMMNVAELELQNCELERIPHAI---FSLSNLQELDLKSNNIRTIEEIISFQHLKRLT 686
Query: 124 ILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPE 182
L L+HN I IP +I +++ L L S N+L +LP + L L+ L S N + +P
Sbjct: 687 CLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPI 746
Query: 183 EIGQLKQLMELDVSCNE-----------------------ITALPQQIGQLKSLRELNVR 219
EIG L+ L L ++ N+ IT+LP+++GQL L +L ++
Sbjct: 747 EIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELK 806
Query: 220 RNYLKVLPQELVDLPLVK 237
N L LP +L ++K
Sbjct: 807 GNCLDRLPAQLGQCRMLK 824
Score = 67.4 bits (163), Expect = 4e-11
Identities = 44/129 (34%), Positives = 73/129 (56%), Gaps = 3/129 (2%)
Query: 105 SKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCG 164
S N+L +P+ + L L++ +N I +IP I LQ L +L+++ N++ LP L
Sbjct: 714 SNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFK 773
Query: 165 -LPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRE--LNVRRN 221
+ L+ L N + SLPE++GQL QL +L++ N + LP Q+GQ + L++ L V +
Sbjct: 774 CIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDH 833
Query: 222 YLKVLPQEL 230
LP E+
Sbjct: 834 LFDTLPLEV 842
Score = 44.7 bits (104), Expect = 3e-04
Identities = 40/155 (25%), Positives = 81/155 (52%), Gaps = 15/155 (9%)
Query: 137 EAIVNLQMLTYLNLSRNQLSALPACLCGLP--LKVLIASNNKLGSLPEEIGQLKQLM--- 191
E++ L+ L L++ N L+ +P+ + + L L+ N+ G+ + LK++M
Sbjct: 582 ESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHND--GTKLLVLNSLKKMMNVA 638
Query: 192 ELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSC-----NKVL 246
EL++ E+ +P I L +L+EL+++ N ++ + +E++ +K +C NK++
Sbjct: 639 ELELQNCELERIPHAIFSLSNLQELDLKSNNIRTI-EEIISFQHLK-RLTCLKLWHNKIV 696
Query: 247 VIPICFREMKQLQVLLLENNPLQSPPAQICTKGKV 281
IP +K L+ L NN L+S P + + K+
Sbjct: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKL 731
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 81.6 bits (200), Expect = 2e-15
Identities = 59/184 (32%), Positives = 99/184 (53%), Gaps = 4/184 (2%)
Query: 96 LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIV--NLQMLTYLNLSRN 153
+ + + +L L +P + +L+ L+L N IR I E I +L+ LT L L N
Sbjct: 634 MMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHN 693
Query: 154 QLSALPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKS 212
++ +P + + L+ L SNNKL SLP + L++L LDVS N I+ +P +IG L++
Sbjct: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
Query: 213 LRELNVRRNYLKVLPQELVD-LPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSP 271
L+ L++ N + +LP++L + L + N + +P ++ QL L L+ N L
Sbjct: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRL 813
Query: 272 PAQI 275
PAQ+
Sbjct: 814 PAQL 817
Score = 74.3 bits (181), Expect = 4e-13
Identities = 58/198 (29%), Positives = 92/198 (46%), Gaps = 29/198 (14%)
Query: 66 ALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKN--RLVEVPMELCHFVSLE 123
+L++ N L L +L+ P LS+ + DL N R +E + H L
Sbjct: 630 SLKKMMNVAELELQNCELERIPHAI---FSLSNLQELDLKSNNIRTIEEIISFQHLKRLT 686
Query: 124 ILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPE 182
L L+HN I IP +I +++ L L S N+L +LP + L L+ L S N + +P
Sbjct: 687 CLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPI 746
Query: 183 EIGQLKQLMELDVSCNE-----------------------ITALPQQIGQLKSLRELNVR 219
EIG L+ L L ++ N+ IT+LP+++GQL L +L ++
Sbjct: 747 EIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELK 806
Query: 220 RNYLKVLPQELVDLPLVK 237
N L LP +L ++K
Sbjct: 807 GNCLDRLPAQLGQCRMLK 824
Score = 67.4 bits (163), Expect = 4e-11
Identities = 44/129 (34%), Positives = 73/129 (56%), Gaps = 3/129 (2%)
Query: 105 SKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCG 164
S N+L +P+ + L L++ +N I +IP I LQ L +L+++ N++ LP L
Sbjct: 714 SNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFK 773
Query: 165 -LPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRE--LNVRRN 221
+ L+ L N + SLPE++GQL QL +L++ N + LP Q+GQ + L++ L V +
Sbjct: 774 CIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDH 833
Query: 222 YLKVLPQEL 230
LP E+
Sbjct: 834 LFDTLPLEV 842
Score = 44.7 bits (104), Expect = 3e-04
Identities = 40/155 (25%), Positives = 81/155 (52%), Gaps = 15/155 (9%)
Query: 137 EAIVNLQMLTYLNLSRNQLSALPACLCGLP--LKVLIASNNKLGSLPEEIGQLKQLM--- 191
E++ L+ L L++ N L+ +P+ + + L L+ N+ G+ + LK++M
Sbjct: 582 ESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHND--GTKLLVLNSLKKMMNVA 638
Query: 192 ELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSC-----NKVL 246
EL++ E+ +P I L +L+EL+++ N ++ + +E++ +K +C NK++
Sbjct: 639 ELELQNCELERIPHAIFSLSNLQELDLKSNNIRTI-EEIISFQHLK-RLTCLKLWHNKIV 696
Query: 247 VIPICFREMKQLQVLLLENNPLQSPPAQICTKGKV 281
IP +K L+ L NN L+S P + + K+
Sbjct: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKL 731
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 81.3 bits (199), Expect = 3e-15
Identities = 65/213 (30%), Positives = 97/213 (45%), Gaps = 17/213 (7%)
Query: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
LNL +LK PR + L ++ N L EVP EL LE+L+L HNC+ +
Sbjct: 99 LNLCGNRLKSLPREVSLLQCLKVLF---VNMNCLTEVPAELSLCRKLEVLSLSHNCLSQL 155
Query: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLMELD 194
P +L L LNLS N + +P C+ L L L +N+L ++ E I L L
Sbjct: 156 PACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFI 215
Query: 195 VSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFRE 254
N I + P+ + + SL LN+ N ++ LP EL C ++ I +
Sbjct: 216 AEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSEL--------HLLCR---LVRIAWNP 264
Query: 255 MKQLQVLLLENNPLQSPPAQICTKGKVHIFKYL 287
M + L + +NPL P ++ G +F YL
Sbjct: 265 MD--KGLHISHNPLSKPLPELVEGGLEMLFGYL 295
Score = 77.4 bits (189), Expect = 4e-14
Identities = 53/179 (29%), Positives = 87/179 (48%), Gaps = 2/179 (1%)
Query: 100 VQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALP 159
V L + ++P L ++ LNL HN +RV+P + L + LNL N+L +LP
Sbjct: 51 VSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLP 110
Query: 160 ACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNV 218
+ L LKVL + N L +P E+ ++L L +S N ++ LP L LR+LN+
Sbjct: 111 REVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNL 170
Query: 219 RRNYLKVLPQELVDL-PLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQIC 276
N+ +P + L L+ N++ I + + LQ+ + E N + S P +C
Sbjct: 171 SNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLC 229
Score = 70.1 bits (170), Expect = 7e-12
Identities = 55/183 (30%), Positives = 95/183 (51%), Gaps = 4/183 (2%)
Query: 96 LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQL 155
LS+ + +LS N+L +P E+ + +LNL N ++ +P + LQ L L ++ N L
Sbjct: 70 LSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCL 129
Query: 156 SALPA--CLCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSL 213
+ +PA LC L+VL S+N L LP L +L +L++S N +P + LK L
Sbjct: 130 TEVPAELSLC-RKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKEL 188
Query: 214 RELNVRRNYLKVLPQELVDLPLVK-FDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPP 272
L+V N L+ + + + L ++ F N + P + L++L L NN +Q+ P
Sbjct: 189 IFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLP 248
Query: 273 AQI 275
+++
Sbjct: 249 SEL 251
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,033,015
Number of Sequences: 37866
Number of extensions: 1519385
Number of successful extensions: 17286
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 299
Number of HSP's successfully gapped in prelim test: 184
Number of HSP's that attempted gapping in prelim test: 11287
Number of HSP's gapped (non-prelim): 3509
length of query: 728
length of database: 18,247,518
effective HSP length: 110
effective length of query: 618
effective length of database: 14,082,258
effective search space: 8702835444
effective search space used: 8702835444
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.