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Search of human proteins with 33598960
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]
(450 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens] 920 0.0
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 422 e-118
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] 405 e-113
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 212 6e-55
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 211 1e-54
gi|4503385 dopamine receptor D2 isoform long [Homo sapiens] 209 4e-54
gi|32483397 dopamine receptor D4 [Homo sapiens] 206 3e-53
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 191 9e-49
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 171 9e-43
gi|194018562 histamine receptor H3 [Homo sapiens] 170 2e-42
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 166 4e-41
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 166 4e-41
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 166 4e-41
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 166 4e-41
gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens] 161 1e-39
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 155 9e-38
gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens] 154 2e-37
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 147 2e-35
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 146 4e-35
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 145 7e-35
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 139 4e-33
gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens] 139 5e-33
gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] 136 4e-32
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] 136 4e-32
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] 136 4e-32
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] 136 4e-32
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] 136 4e-32
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] 136 4e-32
gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] 136 4e-32
gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] 136 4e-32
>gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]
Length = 450
Score = 920 bits (2378), Expect = 0.0
Identities = 450/450 (100%), Positives = 450/450 (100%)
Query: 1 MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADIL 60
MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADIL
Sbjct: 1 MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADIL 60
Query: 61 VATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEY 120
VATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEY
Sbjct: 61 VATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEY 120
Query: 121 NSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGS 180
NSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGS
Sbjct: 121 NSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGS 180
Query: 181 FFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASV 240
FFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASV
Sbjct: 181 FFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASV 240
Query: 241 ASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEE 300
ASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEE
Sbjct: 241 ASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEE 300
Query: 301 EEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRR 360
EEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRR
Sbjct: 301 EEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRR 360
Query: 361 AQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSS 420
AQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSS
Sbjct: 361 AQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSS 420
Query: 421 LNPVIYTIFNQDFRRAFRRILCRPWTQTAW 450
LNPVIYTIFNQDFRRAFRRILCRPWTQTAW
Sbjct: 421 LNPVIYTIFNQDFRRAFRRILCRPWTQTAW 450
>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
Length = 465
Score = 422 bits (1084), Expect = e-118
Identities = 242/453 (53%), Positives = 290/453 (64%), Gaps = 51/453 (11%)
Query: 6 PYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLI 65
PYS+Q T + L+L T+FGN LVI+AV TSR+L+APQNLFLVSLA+ADILVATL+
Sbjct: 42 PYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLV 101
Query: 66 IPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRT 125
IPFSLANE++GYWYF + WCE+YLALDVLFCTSSIVHLCAISLDRYW++++A+EYN KRT
Sbjct: 102 IPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRT 161
Query: 126 PRRIKCIILTVWLIAAVISLPPLI----YKGDQGPQPRGRPQCKLNQEAWYILASSIGSF 181
PRRIK II+TVW+I+AVIS PPLI G GPQP P+C++N + WY+++S IGSF
Sbjct: 162 PRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQP-AEPRCEINDQKWYVISSCIGSF 220
Query: 182 FAPCLIMILVYLRIYLIAKR-----SNRRGPRAKGGPGQGESKQPR---PDHGGALASAK 233
FAPCLIMILVY+RIY IAKR +RRGP A P G ++P P+ A+
Sbjct: 221 FAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAE 280
Query: 234 LPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASP 293
L + ++NG + GE P DT L S S
Sbjct: 281 AEPLPT-----QLNG---APGEPAPA-GPRDTDALDLEES------------------SS 313
Query: 294 EDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRG---VG 350
D AE E P+ + AS P P+ AT G G G VG
Sbjct: 314 SDHAERPPGPRRPER--GPRGKGKARASQVKPGDSLPRRGPG-ATGIGTPAAGPGEERVG 370
Query: 351 AIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQF 410
A WR R REKRFTFVLAVVIGVFV+CWFPFFF+Y+L A+ C VP LF+F
Sbjct: 371 AAKASRWRGRQ--NREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV---GCSVPRTLFKF 425
Query: 411 FFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCR 443
FFW GYCNSSLNPVIYTIFN DFRRAF++ILCR
Sbjct: 426 FFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCR 458
>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
Length = 462
Score = 405 bits (1042), Expect = e-113
Identities = 238/440 (54%), Positives = 280/440 (63%), Gaps = 34/440 (7%)
Query: 7 YSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLII 66
YS A A +AA + FLI+FT+ GN LV++AVLTSR+LRAPQNLFLVSLA+ADILVATL++
Sbjct: 46 YSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVM 105
Query: 67 PFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTP 126
PFSLANEL+ YWYF + WC VYLALDVLFCTSSIVHLCAISLDRYW+V++A+EYN KRTP
Sbjct: 106 PFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTP 165
Query: 127 RRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCL 186
RR+K I+ VWLI+AVIS PPL+ Q P PQC LN E WYIL+S IGSFFAPCL
Sbjct: 166 RRVKATIVAVWLISAVISFPPLVSLYRQ-PDGAAYPQCGLNDETWYILSSCIGSFFAPCL 224
Query: 187 IMILVYLRIYLIAKRSNR--RGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAR 244
IM LVY RIY +AK R RA GP + P ++G L + A A
Sbjct: 225 IMGLVYARIYRVAKLRTRTLSEKRAPVGP---DGASPTTENG----------LGAAAGAG 271
Query: 245 EVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEE 304
E NGH + E E + AL G+ + GA D
Sbjct: 272 E-NGH--CAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGAD--------- 319
Query: 305 EEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRG-QVLLGRGVGAIGGQWWRRRAQL 363
+ P A +A P P G A+ R + L R A R+ AQ
Sbjct: 320 --GQGAGPGAAESGALTASRSP--GPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQ- 374
Query: 364 TREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNP 423
REKRFTFVLAVV+GVFVLCWFPFFFSYSL IC + C+VP LF+FFFWIGYCNSSLNP
Sbjct: 375 AREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNP 434
Query: 424 VIYTIFNQDFRRAFRRILCR 443
VIYT+FNQDFRR+F+ IL R
Sbjct: 435 VIYTVFNQDFRRSFKHILFR 454
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 212 bits (539), Expect = 6e-55
Identities = 136/429 (31%), Positives = 224/429 (52%), Gaps = 57/429 (13%)
Query: 16 AAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELL 75
A +T LI +FGN LV +AV ++L+ N +VSLA AD+LVATL++P+ + E++
Sbjct: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
Query: 76 GYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSK-RTPRRIKCIIL 134
G W F R C++++ LDV+ CT+SI++LCAIS+DRY AV+ + YN++ + RR+ +I
Sbjct: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
Query: 135 TVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLR 194
VW+++ IS P L G + +C + A +++ SSI SF+ P ++ +LVY++
Sbjct: 158 IVWVLSFTISCPLLF-----GLNNADQNECIIANPA-FVVYSSIVSFYVPFIVTLLVYIK 211
Query: 195 IYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTG 254
IY++ +R +R + A + P + A+E+ S+
Sbjct: 212 IYIVLRRRRKR-------------VNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSS- 257
Query: 255 EKEEGETPEDTGTRALPPS--WAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEP 312
PE T +PPS LP+ G+ ++P+ A+ E+ ++
Sbjct: 258 ----TSPPERTRYSPIPPSHHQLTLPDPSH---HGL-HSTPDSPAKPEKNGHAKDH---- 305
Query: 313 QAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFV 372
P A +Q + +L+ RR+ +EK+ T +
Sbjct: 306 ------PKIAKIFEIQTMPNGKTRTSLKTMS--------------RRKLSQQKEKKATQM 345
Query: 373 LAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQD 432
LA+V+GVF++CW PFF ++ L C C +P L+ F W+GY NS++NP+IYT FN +
Sbjct: 346 LAIVLGVFIICWLPFFITHILNIHC--DCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIE 403
Query: 433 FRRAFRRIL 441
FR+AF +IL
Sbjct: 404 FRKAFLKIL 412
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 211 bits (536), Expect = 1e-54
Identities = 131/425 (30%), Positives = 213/425 (50%), Gaps = 60/425 (14%)
Query: 22 LILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFR 81
LI + GNA V+ A+ RSL+ N + SLA D++V+ L++P + ++L W
Sbjct: 46 LIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLG 105
Query: 82 RTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAA 141
+ C++++ALDVL CTSSI+HLCAI+LDRYWA++ ++Y +KRTPRR +I WLI
Sbjct: 106 QVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGF 165
Query: 142 VISLPPLIYKGDQGPQPRGRPQ-CKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIA- 199
+IS+PP++ G + P+ R P C ++++ Y + S+ G+F+ P L+M+++Y RI+ A
Sbjct: 166 LISIPPML--GWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAAR 223
Query: 200 ---KRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEK 256
+++ ++ + G S P+P + VNG S S +
Sbjct: 224 FRIRKTVKKVEKTGADTRHGASPAPQP-------------------KKSVNGESGSRNWR 264
Query: 257 EEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVP 316
E+ + AL +G ++G GA+ E +E +A P
Sbjct: 265 LGVES----------KAGGALCANG-AVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGP 313
Query: 317 VSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVV 376
+ C+P + + R +R+ L RE++ L ++
Sbjct: 314 ----TPCAPASFERKNERNAEA-------------------KRKMALARERKTVKTLGII 350
Query: 377 IGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRA 436
+G F+LCW PFF + C C +P L W+GY NS LNPVIY FN+DF+ A
Sbjct: 351 MGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNA 410
Query: 437 FRRIL 441
F++I+
Sbjct: 411 FKKII 415
>gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
Length = 443
Score = 209 bits (532), Expect = 4e-54
Identities = 141/447 (31%), Positives = 229/447 (51%), Gaps = 64/447 (14%)
Query: 16 AAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELL 75
A +T LI +FGN LV +AV ++L+ N +VSLA AD+LVATL++P+ + E++
Sbjct: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
Query: 76 GYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSK-RTPRRIKCIIL 134
G W F R C++++ LDV+ CT+SI++LCAIS+DRY AV+ + YN++ + RR+ +I
Sbjct: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
Query: 135 TVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLR 194
VW+++ IS P L G + +C + A +++ SSI SF+ P ++ +LVY++
Sbjct: 158 IVWVLSFTISCPLLF-----GLNNADQNECIIANPA-FVVYSSIVSFYVPFIVTLLVYIK 211
Query: 195 IYLI---------AKRSNRRGPRAKGGPGQGESKQPR---------PDHGGALASAKLPA 236
IY++ KRS+R P +G P +G + +
Sbjct: 212 IYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVE 271
Query: 237 LASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPS--WAALPNSGQGQKEGVCGASPE 294
A A E+ S ++ PE T +PPS LP+ G+ ++P+
Sbjct: 272 AARRAQELEMEMLSSTS-------PPERTRYSPIPPSHHQLTLPDPSH---HGL-HSTPD 320
Query: 295 DEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGG 354
A+ E+ ++ P A +Q + +L+
Sbjct: 321 SPAKPEKNGHAKDH----------PKIAKIFEIQTMPNGKTRTSLKTMS----------- 359
Query: 355 QWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWI 414
RR+ +EK+ T +LA+V+GVF++CW PFF ++ L C C +P L+ F W+
Sbjct: 360 ---RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHC--DCNIPPVLYSAFTWL 414
Query: 415 GYCNSSLNPVIYTIFNQDFRRAFRRIL 441
GY NS++NP+IYT FN +FR+AF +IL
Sbjct: 415 GYVNSAVNPIIYTTFNIEFRKAFLKIL 441
>gi|32483397 dopamine receptor D4 [Homo sapiens]
Length = 419
Score = 206 bits (524), Expect = 3e-53
Identities = 153/449 (34%), Positives = 222/449 (49%), Gaps = 83/449 (18%)
Query: 10 QATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFS 69
Q AA+ + LI + GN+LV ++V T R+L+ P N F+VSLAAAD+L+A L++P
Sbjct: 33 QGAAALVGGV-LLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLF 91
Query: 70 LANELLG-YWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRR 128
+ +E+ G W C+ +A+DV+ CT+SI +LCAIS+DR+ AV+ L YN + RR
Sbjct: 92 VYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRR 151
Query: 129 IKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQ--CKLNQEAWYILASSIGSFFAPCL 186
+I WL++A ++ P L D RGR C+L ++ Y++ SS+ SFF PC
Sbjct: 152 QLLLIGATWLLSAAVAAPVLCGLND----VRGRDPAVCRL-EDRDYVVYSSVCSFFLPCP 206
Query: 187 IMILVY------LRIYLIAKRS--NRRGPRAKGGPGQGESKQPRP----DHGGALASAKL 234
+M+L+Y L+ + +A+R+ + R PR GPG P P D G +
Sbjct: 207 LMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPA 266
Query: 235 PALASVASAREVNGHSKSTGEKEEGETPED-TGTRALPPSWAALPNSGQGQKEGVCGASP 293
P L + + S P+D G PP+ P+ CG++
Sbjct: 267 PGLPRGPCGPDCAPAAPS--------LPQDPCGPDCAPPAPGLPPDP--------CGSN- 309
Query: 294 EDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIG 353
C P P + +A PP PQ R
Sbjct: 310 ----------------CAP---PDAVRAAALPPQTPPQTRR------------------- 331
Query: 354 GQWWRRRAQLT-REKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFF 412
RRRA++T RE++ VL VV+G F+LCW PFF + A+CP C VP L
Sbjct: 332 ----RRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPA-CSVPPRLVSAVT 386
Query: 413 WIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441
W+GY NS+LNPVIYT+FN +FR FR+ L
Sbjct: 387 WLGYVNSALNPVIYTVFNAEFRNVFRKAL 415
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 191 bits (486), Expect = 9e-49
Identities = 135/433 (31%), Positives = 211/433 (48%), Gaps = 68/433 (15%)
Query: 13 AAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLAN 72
A A + LIL +FGN LV +AVL R+L+ N +VSLA AD+LVATL++P+ +
Sbjct: 30 AYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYL 89
Query: 73 ELLG-YWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEY---NSKRTPRR 128
E+ G W F R C+V++ LDV+ CT+SI++LCAIS+DRY AV + Y + + RR
Sbjct: 90 EVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRR 149
Query: 129 IKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIM 188
+ +I VW++A +S P L G G P +++ SS+ SF+ P +
Sbjct: 150 VALMITAVWVLAFAVSCPLLF-----GFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVT 204
Query: 189 ILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNG 248
+LVY RIY++ K+ R+ + + +
Sbjct: 205 VLVYARIYVVLKQRRRK---------------------------------RILTRQNSQC 231
Query: 249 HSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEE 308
+S G ++ +P D L ++ ++ G G ++ E + EE+
Sbjct: 232 NSVRPGFPQQTLSP-DPAHLELKRYYSICQDTALG------GPGFQERGGELKREEKTRN 284
Query: 309 ECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKR 368
P P S +++ R+ +L+ L RGV REK+
Sbjct: 285 SLSPTIAP-----KLSLEVRKLSNGRLSTSLKLGPLQPRGVP-------------LREKK 326
Query: 369 FTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTI 428
T ++A+V+G F++CW PFF ++ L C + C V L+ W+GY NS+LNPVIYT
Sbjct: 327 ATQMVAIVLGAFIVCWLPFFLTHVLNTHC-QTCHVSPELYSATTWLGYVNSALNPVIYTT 385
Query: 429 FNQDFRRAFRRIL 441
FN +FR+AF +IL
Sbjct: 386 FNIEFRKAFLKIL 398
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 171 bits (434), Expect = 9e-43
Identities = 85/195 (43%), Positives = 133/195 (68%), Gaps = 4/195 (2%)
Query: 12 TAAIAAAITF--LILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFS 69
T AI+ + ILF I GN LVIL+V +R LR P N F+V+LA AD+L++ ++PFS
Sbjct: 43 TRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFS 102
Query: 70 LANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRI 129
A E+LGYW R +C+++ A+DVL CT+SI+ LCAIS+DRY V +L+Y + T R+
Sbjct: 103 AALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKA 162
Query: 130 KCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMI 189
+L+VW+++ VIS+ PL+ G + P P +C + +E +Y L SS+GSF+ P +++
Sbjct: 163 ILALLSVWVLSTVISIGPLL--GWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVIL 220
Query: 190 LVYLRIYLIAKRSNR 204
++Y R+Y++AKR+ +
Sbjct: 221 VMYCRVYIVAKRTTK 235
Score = 81.6 bits (200), Expect = 1e-15
Identities = 36/80 (45%), Positives = 54/80 (67%), Gaps = 1/80 (1%)
Query: 362 QLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSL 421
+ +REK+ L +V+G+F+LCW PFF + LG++ K P +F+ FW+GY NS L
Sbjct: 285 KFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFST-LKPPDAVFKVVFWLGYFNSCL 343
Query: 422 NPVIYTIFNQDFRRAFRRIL 441
NP+IY +++F+RAF RIL
Sbjct: 344 NPIIYPCSSKEFKRAFVRIL 363
>gi|194018562 histamine receptor H3 [Homo sapiens]
Length = 445
Score = 170 bits (431), Expect = 2e-42
Identities = 129/443 (29%), Positives = 200/443 (45%), Gaps = 50/443 (11%)
Query: 7 YSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLII 66
+S TA +AA + LI+ T+ GNALV+LA + SLR N FL++LA +D LV I
Sbjct: 29 FSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCI 88
Query: 67 PFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKR-T 125
P + L G W F R C+++L +D L CTSS ++ IS DR+ +V+RA+ Y +++
Sbjct: 89 PLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGD 148
Query: 126 PRRIKCIILTVWLIAAVISLPPLI---YKGDQGPQPRGRPQCKLNQEAWYILASSIGSFF 182
RR +L VW++A ++ P ++ Y P G + ++++ +S FF
Sbjct: 149 TRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFF 208
Query: 183 APCLIMILVYLRIYLIAKRSNR---RGPRAKGGPGQGESKQPRPDHGGALASAKLPALAS 239
P L + L IYL +R R G R GP QP P P
Sbjct: 209 TPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSP-----------PPPPG 257
Query: 240 VASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEE 299
+ GH ++ G G A A L G G ASP +
Sbjct: 258 CWGCWQ-KGHGEAMPLHRYGVGEAAVGAEA---GEATLGGGGGGGSV----ASPTSSSGS 309
Query: 300 EEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRR 359
E + + P SA S L++ + Q + +
Sbjct: 310 SSRGTERPRSLKRGSKP----SASSASLEKRM-------------------KMVSQSFTQ 346
Query: 360 RAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNS 419
R +L+R+++ LAV++ +F LCW P+ + A C HC VP ++ FW+ + NS
Sbjct: 347 RFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHC-VPDYWYETSFWLLWANS 405
Query: 420 SLNPVIYTIFNQDFRRAFRRILC 442
++NPV+Y + + FRRAF ++LC
Sbjct: 406 AVNPVLYPLCHHSFRRAFTKLLC 428
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 166 bits (420), Expect = 4e-41
Identities = 97/247 (39%), Positives = 146/247 (59%), Gaps = 13/247 (5%)
Query: 4 QDPYSVQATAAIAAAITF--LILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILV 61
Q P V + AI + LILF + GN LVIL+V R L + + ++V+LA AD+L+
Sbjct: 16 QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLL 75
Query: 62 ATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYN 121
+ ++PFS E+LGYW F R +C ++ A+DVL CT+SI+ LC IS+DRY VS L Y
Sbjct: 76 TSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP 135
Query: 122 SKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSF 181
+ T RR +L VW ++ VIS+ PL G + P P C++N+E Y+L S++GSF
Sbjct: 136 TIVTQRRGLMALLCVWALSLVISIGPLF--GWRQPAPEDETICQINEEPGYVLFSALGSF 193
Query: 182 FAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQ--------PRPDHGGALASAK 233
+ P I++++Y R+Y++AKR + RG ++ + +S+Q P G +ASAK
Sbjct: 194 YLPLAIILVMYCRVYVVAKRES-RGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAK 252
Query: 234 LPALASV 240
SV
Sbjct: 253 TKTHFSV 259
Score = 78.6 bits (192), Expect = 1e-14
Identities = 34/83 (40%), Positives = 52/83 (62%), Gaps = 1/83 (1%)
Query: 359 RRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCN 418
R + +REK+ L +V+G FVLCW PFF +G+ P K +F+ FW+GY N
Sbjct: 260 RLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDF-KPSETVFKIVFWLGYLN 318
Query: 419 SSLNPVIYTIFNQDFRRAFRRIL 441
S +NP+IY +Q+F++AF+ +L
Sbjct: 319 SCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 166 bits (420), Expect = 4e-41
Identities = 97/247 (39%), Positives = 146/247 (59%), Gaps = 13/247 (5%)
Query: 4 QDPYSVQATAAIAAAITF--LILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILV 61
Q P V + AI + LILF + GN LVIL+V R L + + ++V+LA AD+L+
Sbjct: 16 QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLL 75
Query: 62 ATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYN 121
+ ++PFS E+LGYW F R +C ++ A+DVL CT+SI+ LC IS+DRY VS L Y
Sbjct: 76 TSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP 135
Query: 122 SKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSF 181
+ T RR +L VW ++ VIS+ PL G + P P C++N+E Y+L S++GSF
Sbjct: 136 TIVTQRRGLMALLCVWALSLVISIGPLF--GWRQPAPEDETICQINEEPGYVLFSALGSF 193
Query: 182 FAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQ--------PRPDHGGALASAK 233
+ P I++++Y R+Y++AKR + RG ++ + +S+Q P G +ASAK
Sbjct: 194 YLPLAIILVMYCRVYVVAKRES-RGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAK 252
Query: 234 LPALASV 240
SV
Sbjct: 253 TKTHFSV 259
Score = 78.6 bits (192), Expect = 1e-14
Identities = 34/83 (40%), Positives = 52/83 (62%), Gaps = 1/83 (1%)
Query: 359 RRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCN 418
R + +REK+ L +V+G FVLCW PFF +G+ P K +F+ FW+GY N
Sbjct: 260 RLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDF-KPSETVFKIVFWLGYLN 318
Query: 419 SSLNPVIYTIFNQDFRRAFRRIL 441
S +NP+IY +Q+F++AF+ +L
Sbjct: 319 SCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 166 bits (420), Expect = 4e-41
Identities = 97/247 (39%), Positives = 146/247 (59%), Gaps = 13/247 (5%)
Query: 4 QDPYSVQATAAIAAAITF--LILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILV 61
Q P V + AI + LILF + GN LVIL+V R L + + ++V+LA AD+L+
Sbjct: 16 QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLL 75
Query: 62 ATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYN 121
+ ++PFS E+LGYW F R +C ++ A+DVL CT+SI+ LC IS+DRY VS L Y
Sbjct: 76 TSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP 135
Query: 122 SKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSF 181
+ T RR +L VW ++ VIS+ PL G + P P C++N+E Y+L S++GSF
Sbjct: 136 TIVTQRRGLMALLCVWALSLVISIGPLF--GWRQPAPEDETICQINEEPGYVLFSALGSF 193
Query: 182 FAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQ--------PRPDHGGALASAK 233
+ P I++++Y R+Y++AKR + RG ++ + +S+Q P G +ASAK
Sbjct: 194 YLPLAIILVMYCRVYVVAKRES-RGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAK 252
Query: 234 LPALASV 240
SV
Sbjct: 253 TKTHFSV 259
Score = 78.6 bits (192), Expect = 1e-14
Identities = 34/83 (40%), Positives = 52/83 (62%), Gaps = 1/83 (1%)
Query: 359 RRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCN 418
R + +REK+ L +V+G FVLCW PFF +G+ P K +F+ FW+GY N
Sbjct: 260 RLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDF-KPSETVFKIVFWLGYLN 318
Query: 419 SSLNPVIYTIFNQDFRRAFRRIL 441
S +NP+IY +Q+F++AF+ +L
Sbjct: 319 SCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 166 bits (420), Expect = 4e-41
Identities = 97/247 (39%), Positives = 146/247 (59%), Gaps = 13/247 (5%)
Query: 4 QDPYSVQATAAIAAAITF--LILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILV 61
Q P V + AI + LILF + GN LVIL+V R L + + ++V+LA AD+L+
Sbjct: 16 QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLL 75
Query: 62 ATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYN 121
+ ++PFS E+LGYW F R +C ++ A+DVL CT+SI+ LC IS+DRY VS L Y
Sbjct: 76 TSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP 135
Query: 122 SKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSF 181
+ T RR +L VW ++ VIS+ PL G + P P C++N+E Y+L S++GSF
Sbjct: 136 TIVTQRRGLMALLCVWALSLVISIGPLF--GWRQPAPEDETICQINEEPGYVLFSALGSF 193
Query: 182 FAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQ--------PRPDHGGALASAK 233
+ P I++++Y R+Y++AKR + RG ++ + +S+Q P G +ASAK
Sbjct: 194 YLPLAIILVMYCRVYVVAKRES-RGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAK 252
Query: 234 LPALASV 240
SV
Sbjct: 253 TKTHFSV 259
Score = 78.6 bits (192), Expect = 1e-14
Identities = 34/83 (40%), Positives = 52/83 (62%), Gaps = 1/83 (1%)
Query: 359 RRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCN 418
R + +REK+ L +V+G FVLCW PFF +G+ P K +F+ FW+GY N
Sbjct: 260 RLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDF-KPSETVFKIVFWLGYLN 318
Query: 419 SSLNPVIYTIFNQDFRRAFRRIL 441
S +NP+IY +Q+F++AF+ +L
Sbjct: 319 SCINPIIYPCSSQEFKKAFQNVL 341
>gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]
Length = 460
Score = 161 bits (408), Expect = 1e-39
Identities = 119/445 (26%), Positives = 200/445 (44%), Gaps = 35/445 (7%)
Query: 13 AAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLAN 72
A I L L T+ GN LV+++ + L+ N FL+SLA AD+++ T +
Sbjct: 26 AFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTY 85
Query: 73 ELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCI 132
L+G+W C+++LALD + +S+++L IS DRY++V+R L Y +KRTPRR +
Sbjct: 86 LLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALM 145
Query: 133 ILTVWLIAAVISLPPLI---YKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMI 189
I WL++ V+ P ++ Y + G+ + + +++ +F+ P +M
Sbjct: 146 IGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMC 205
Query: 190 LVYLRIYLIAKRSNRRGPRAKGG--PGQGESKQPRPDHGGALASAKLPALASVASAREVN 247
+Y RIY + R +G PG+G GG+ +S++
Sbjct: 206 TLYWRIYRETENRARELAALQGSETPGKG---------GGSSSSSE-------------- 242
Query: 248 GHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEE 307
G + ETP R S + ++E G+ + E EE E
Sbjct: 243 --RSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV 300
Query: 308 EECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRA--QLTR 365
P P + A PP P + T +G+ G+G G + +R L +
Sbjct: 301 VIKMPMVDPEAQAPTKQPPRSSPNTVK-RPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVK 359
Query: 366 EKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVI 425
EK+ L+ ++ F+L W P+ + C K C VP L++ +W+ Y NS++NP+
Sbjct: 360 EKKAARTLSAILLAFILTWTPYNIMVLVSTFC-KDC-VPETLWELGYWLCYVNSTINPMC 417
Query: 426 YTIFNQDFRRAFRRILCRPWTQTAW 450
Y + N+ FR FR +L W + W
Sbjct: 418 YALCNKAFRDTFRLLLLCRWDKRRW 442
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 155 bits (391), Expect = 9e-38
Identities = 74/190 (38%), Positives = 123/190 (64%), Gaps = 2/190 (1%)
Query: 15 IAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANEL 74
+ + IL + GN LVIL+V +R L+ N F+V+LA AD+L++ ++PFS E+
Sbjct: 99 VGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEV 158
Query: 75 LGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIIL 134
LG+W F R +C+V+ A+DVL CT+SI+ LC IS+DRY V +L+Y + T R+ I+
Sbjct: 159 LGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILA 218
Query: 135 TVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLR 194
+W++A V+S+ PL+ G + P P C + +EA Y + SS+ SF+ P +++++Y R
Sbjct: 219 LLWVVALVVSVGPLL--GWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCR 276
Query: 195 IYLIAKRSNR 204
+Y++A+ + R
Sbjct: 277 VYVVARSTTR 286
Score = 90.5 bits (223), Expect = 3e-18
Identities = 41/83 (49%), Positives = 59/83 (71%), Gaps = 1/83 (1%)
Query: 359 RRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCN 418
R + +REK+ LA+V+GVFVLCWFPFFF LG++ P+ K G+F+ FW+GY N
Sbjct: 336 RLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQ-LKPSEGVFKVIFWLGYFN 394
Query: 419 SSLNPVIYTIFNQDFRRAFRRIL 441
S +NP+IY +++F+RAF R+L
Sbjct: 395 SCVNPLIYPCSSREFKRAFLRLL 417
>gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]
Length = 532
Score = 154 bits (388), Expect = 2e-37
Identities = 120/485 (24%), Positives = 212/485 (43%), Gaps = 57/485 (11%)
Query: 15 IAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANEL 74
IAA + L TI GN LV+++ + L+ N +L+SLA AD+++ + L
Sbjct: 33 IAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYIL 92
Query: 75 LGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIIL 134
+G W C+++LALD + +S+++L IS DRY++++R L Y +KRTP+R +I
Sbjct: 93 MGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIG 152
Query: 135 TVWLIAAVISLPPLI---YKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILV 191
WLI+ ++ P ++ Y + P Q + E ++I +F+ P +M ++
Sbjct: 153 LAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTIL 212
Query: 192 YLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSK 251
Y RIY ++ + +G ++++ +P H AL + L + RE N S
Sbjct: 213 YCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAH-RALFRSCLRCPRPTLAQRERNQASW 271
Query: 252 STGEKEEGETPEDTGTRALPPSWA---------ALPNSGQGQK-------------EGVC 289
S+ + T + + +WA + P+S K +G
Sbjct: 272 SSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKE 331
Query: 290 GASPEDEAEEEEE----EEEEEEECEPQAVPVSPASACSPPLQQ--PQGSRVLATLRGQV 343
E AEE EE E E+ + + +SPA+A P Q+ R++ G
Sbjct: 332 SPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQ 391
Query: 344 LLGRGVGAI-----------------------GGQWWRRRAQLTREKRFTFVLAVVIGVF 380
G + R+R L +E++ L+ ++ F
Sbjct: 392 ETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAF 451
Query: 381 VLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRI 440
++ W P+ + C K C VP L+ +W+ Y NS++NP+ Y + N+ FR+ F+ +
Sbjct: 452 IITWTPYNIMVLVSTFCDK-C-VPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKML 509
Query: 441 LCRPW 445
L W
Sbjct: 510 LLCRW 514
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 147 bits (371), Expect = 2e-35
Identities = 75/209 (35%), Positives = 123/209 (58%), Gaps = 4/209 (1%)
Query: 5 DPYSVQATA-AIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVAT 63
DP ++QA ++A ++ + L T+ NA V+ +L +R L P N + SLA D+LV+
Sbjct: 30 DPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSI 89
Query: 64 LIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSK 123
L++P S+A + W F + C+++L+ D+ CT+SI+HLC I+LDRYWA++ ALEY+ +
Sbjct: 90 LVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKR 149
Query: 124 RTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLN-QEAWYILASSIGSFF 182
RT +I VW I+ IS+PPL ++ Q C +N + Y + S+ G+F+
Sbjct: 150 RTAGHAATMIAIVWAISICISIPPLFWR--QAKAQEEMSDCLVNTSQISYTIYSTCGAFY 207
Query: 183 APCLIMILVYLRIYLIAKRSNRRGPRAKG 211
P +++I++Y RIY A+ P G
Sbjct: 208 IPSVLLIILYGRIYRAARNRILNPPSLYG 236
Score = 94.7 bits (234), Expect = 1e-19
Identities = 37/84 (44%), Positives = 58/84 (69%)
Query: 358 RRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYC 417
R+R RE++ T +L +++G F++CW PFF + IC C + LF FF W+GY
Sbjct: 288 RKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYL 347
Query: 418 NSSLNPVIYTIFNQDFRRAFRRIL 441
NS +NP+IYT+FN++FR+AF++I+
Sbjct: 348 NSLINPIIYTVFNEEFRQAFQKIV 371
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 146 bits (368), Expect = 4e-35
Identities = 76/213 (35%), Positives = 121/213 (56%), Gaps = 9/213 (4%)
Query: 3 HQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVA 62
+QD S+ + + + L T NA VI V +R L P N + SLA D+LV+
Sbjct: 40 YQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVS 99
Query: 63 TLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNS 122
L++P S + G W + C+ +L+ D+ CT+SI+HLC I+LDRYWA++ A+EY++
Sbjct: 100 ILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSA 159
Query: 123 KRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQE-AWYILASSIGSF 181
KRTP+R +I VW+ + ISLPP ++ Q +C +N + Y + S++G+F
Sbjct: 160 KRTPKRAAVMIALVWVFSISISLPPFFWR--QAKAEEEVSECVVNTDHILYTVYSTVGAF 217
Query: 182 FAPCLIMILVYLRIY------LIAKRSNRRGPR 208
+ P L++I +Y RIY ++ + NR G R
Sbjct: 218 YFPTLLLIALYGRIYVEARSRILKQTPNRTGKR 250
Score = 84.7 bits (208), Expect = 2e-16
Identities = 32/84 (38%), Positives = 54/84 (64%)
Query: 358 RRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYC 417
+++ RE++ T L +++G F++CW PFF + IC C +F FF W+GY
Sbjct: 301 KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYL 360
Query: 418 NSSLNPVIYTIFNQDFRRAFRRIL 441
NS +NP+IYT+ N+DF++AF +++
Sbjct: 361 NSLINPIIYTMSNEDFKQAFHKLI 384
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 145 bits (366), Expect = 7e-35
Identities = 73/196 (37%), Positives = 116/196 (59%), Gaps = 2/196 (1%)
Query: 6 PYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLI 65
P ++ I + + T N VI+A+ T++ L P N + SLA D+LVA L+
Sbjct: 16 PKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLV 75
Query: 66 IPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRT 125
+P S+ ++ W CEV+L++D+ CT SI+HLC I+LDRYWA++ A+EY KRT
Sbjct: 76 MPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRT 135
Query: 126 PRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQE-AWYILASSIGSFFAP 184
+R +ILTVW I+ IS+PPL ++ + P QC + + Y + S++G+F+ P
Sbjct: 136 AKRAALMILTVWTISIFISMPPLFWRSHRRLSP-PPSQCTIQHDHVIYTIYSTLGAFYIP 194
Query: 185 CLIMILVYLRIYLIAK 200
+++++Y RIY AK
Sbjct: 195 LTLILILYYRIYHAAK 210
Score = 69.7 bits (169), Expect = 5e-12
Identities = 32/90 (35%), Positives = 54/90 (60%), Gaps = 3/90 (3%)
Query: 358 RRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYC 417
R++ TRE++ +L +++G F+L W PFF + + V + F W+GY
Sbjct: 278 RQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGL--SIYTVSSEVADFLTWLGYV 335
Query: 418 NSSLNPVIYTIFNQDFRRAFRRIL-CRPWT 446
NS +NP++YT FN+DF+ AF++++ CR T
Sbjct: 336 NSLINPLLYTSFNEDFKLAFKKLIRCREHT 365
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 139 bits (351), Expect = 4e-33
Identities = 83/256 (32%), Positives = 137/256 (53%), Gaps = 10/256 (3%)
Query: 5 DPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATL 64
+P S Q TA + + ++L + GN LVI+A+ + L+ NLF++SLA+AD+++ L
Sbjct: 51 EPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLL 110
Query: 65 IIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKR 124
++PF + G W + +CE++ ++DVL T+SI LC I+LDRY A++ Y S
Sbjct: 111 VVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLL 170
Query: 125 TPRRIKCIILTVWLIAAVISLPPLIY-----KGDQGPQPRGRPQ-CKLNQEAWYILASSI 178
T R + ++ TVW I+A++S P++ + D+ + P+ C Y +ASS+
Sbjct: 171 TRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSV 230
Query: 179 GSFFAPCLIMILVYLRIYLIAKRSNRR----GPRAKGGPGQGESKQPRPDHGGALASAKL 234
SF+ P IM VYLR++ A++ ++ R GGP + S P P A
Sbjct: 231 VSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPP 290
Query: 235 PALASVASAREVNGHS 250
A+ A+A NG +
Sbjct: 291 RPAAAAATAPLANGRA 306
Score = 77.0 bits (188), Expect = 3e-14
Identities = 51/153 (33%), Positives = 78/153 (50%), Gaps = 19/153 (12%)
Query: 299 EEEEEEEEEEECE---------PQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGV 349
E +++ ++ + CE P + SP A +PP P+ + AT + GR
Sbjct: 250 EAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAAT--APLANGRA- 306
Query: 350 GAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQ 409
G+ R RE++ L +++GVF LCW PFF + + A + VP LF
Sbjct: 307 ----GKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRE--LVPDRLFV 360
Query: 410 FFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILC 442
FF W+GY NS+ NP+IY + DFR+AF+ +LC
Sbjct: 361 FFNWLGYANSAFNPIIY-CRSPDFRKAFQGLLC 392
>gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]
Length = 479
Score = 139 bits (350), Expect = 5e-33
Identities = 116/466 (24%), Positives = 203/466 (43%), Gaps = 55/466 (11%)
Query: 7 YSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLII 66
Y IA L L T+ GN LV+L++ +R L+ N FL SLA AD+++ +
Sbjct: 27 YETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSM 86
Query: 67 PFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTP 126
+ GYW C+++LALD + +S+++L IS DRY+ V++ L Y ++RT
Sbjct: 87 NLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTT 146
Query: 127 RRIKCIILTVWLIAAVISLPPLIY-KGDQGPQPRGRPQCKLN--QEAWYILASSIGSFFA 183
+ +I W+++ V+ P +++ + G + QC + ++I +F+
Sbjct: 147 KMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYL 206
Query: 184 PCLIMILVYLRIYLIAK----RSNRRGPRAKGGPGQGESKQP-------RPDHG------ 226
P +IM ++Y+ I L ++ + GP+ K K P +P G
Sbjct: 207 PVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREE 266
Query: 227 ---GALASAKLPAL-------ASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAA 276
G L A PAL A ++ E + S + KE T T T A P+ A
Sbjct: 267 LRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELST-TEATTPAMPA 325
Query: 277 LPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVL 336
P Q + AS + + ++ E + VP +PA
Sbjct: 326 PPL----QPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAG--------------- 366
Query: 337 ATLRGQVLLGRGVGAIGGQWWRRRAQL-TREKRFTFVLAVVIGVFVLCWFPFFFSYSLGA 395
+R + R +I R++ Q+ RE++ T + ++ F+L W P+ +
Sbjct: 367 --MRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNT 424
Query: 396 ICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441
C + C +P ++ +W+ Y NS++NP Y + N F++ FR +L
Sbjct: 425 FC-QSC-IPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLL 468
>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 136 bits (342), Expect = 4e-32
Identities = 103/454 (22%), Positives = 201/454 (44%), Gaps = 33/454 (7%)
Query: 6 PYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLI 65
PY I L L TI GN LV++++ +R L+ N FL SLA AD+++
Sbjct: 17 PYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFS 76
Query: 66 IPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRT 125
+ ++GYW C+++LALD + +S+++L IS DRY+ V++ L Y KRT
Sbjct: 77 MNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRT 136
Query: 126 PRRIKCIILTVWLIAAVISLPPLIY-KGDQGPQPRGRPQCKLN--QEAWYILASSIGSFF 182
+ +I W+++ ++ P +++ + G + +C + A ++I +F+
Sbjct: 137 TKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 183 APCLIMILVYLRIYLIAK---RSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALAS 239
P +IM ++Y I +K + +++ P A P Q R P +
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGR---------IVKPNNNN 247
Query: 240 VASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEE 299
+ S+ + H+K + G+ P D T ++ V +DE +
Sbjct: 248 MPSSDDGLEHNKI----QNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQ 303
Query: 300 EE----------EEEEEEEECEPQAVPVSPASACSP--PLQQPQGSRVLATLRGQVLLGR 347
+E ++E ++ C + +C+P + GS Q ++ R
Sbjct: 304 DENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVAR 363
Query: 348 GVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGL 407
+ + Q +++ +REK+ T + ++ F++ W P+ + C C +P+ +
Sbjct: 364 KIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAP-C-IPNTV 421
Query: 408 FQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441
+ +W+ Y NS++NP Y + N F++ F+ +L
Sbjct: 422 WTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 136 bits (342), Expect = 4e-32
Identities = 103/454 (22%), Positives = 201/454 (44%), Gaps = 33/454 (7%)
Query: 6 PYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLI 65
PY I L L TI GN LV++++ +R L+ N FL SLA AD+++
Sbjct: 17 PYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFS 76
Query: 66 IPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRT 125
+ ++GYW C+++LALD + +S+++L IS DRY+ V++ L Y KRT
Sbjct: 77 MNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRT 136
Query: 126 PRRIKCIILTVWLIAAVISLPPLIY-KGDQGPQPRGRPQCKLN--QEAWYILASSIGSFF 182
+ +I W+++ ++ P +++ + G + +C + A ++I +F+
Sbjct: 137 TKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 183 APCLIMILVYLRIYLIAK---RSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALAS 239
P +IM ++Y I +K + +++ P A P Q R P +
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGR---------IVKPNNNN 247
Query: 240 VASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEE 299
+ S+ + H+K + G+ P D T ++ V +DE +
Sbjct: 248 MPSSDDGLEHNKI----QNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQ 303
Query: 300 EE----------EEEEEEEECEPQAVPVSPASACSP--PLQQPQGSRVLATLRGQVLLGR 347
+E ++E ++ C + +C+P + GS Q ++ R
Sbjct: 304 DENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVAR 363
Query: 348 GVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGL 407
+ + Q +++ +REK+ T + ++ F++ W P+ + C C +P+ +
Sbjct: 364 KIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAP-C-IPNTV 421
Query: 408 FQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441
+ +W+ Y NS++NP Y + N F++ F+ +L
Sbjct: 422 WTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 136 bits (342), Expect = 4e-32
Identities = 103/454 (22%), Positives = 201/454 (44%), Gaps = 33/454 (7%)
Query: 6 PYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLI 65
PY I L L TI GN LV++++ +R L+ N FL SLA AD+++
Sbjct: 17 PYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFS 76
Query: 66 IPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRT 125
+ ++GYW C+++LALD + +S+++L IS DRY+ V++ L Y KRT
Sbjct: 77 MNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRT 136
Query: 126 PRRIKCIILTVWLIAAVISLPPLIY-KGDQGPQPRGRPQCKLN--QEAWYILASSIGSFF 182
+ +I W+++ ++ P +++ + G + +C + A ++I +F+
Sbjct: 137 TKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 183 APCLIMILVYLRIYLIAK---RSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALAS 239
P +IM ++Y I +K + +++ P A P Q R P +
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGR---------IVKPNNNN 247
Query: 240 VASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEE 299
+ S+ + H+K + G+ P D T ++ V +DE +
Sbjct: 248 MPSSDDGLEHNKI----QNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQ 303
Query: 300 EE----------EEEEEEEECEPQAVPVSPASACSP--PLQQPQGSRVLATLRGQVLLGR 347
+E ++E ++ C + +C+P + GS Q ++ R
Sbjct: 304 DENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVAR 363
Query: 348 GVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGL 407
+ + Q +++ +REK+ T + ++ F++ W P+ + C C +P+ +
Sbjct: 364 KIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAP-C-IPNTV 421
Query: 408 FQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441
+ +W+ Y NS++NP Y + N F++ F+ +L
Sbjct: 422 WTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 136 bits (342), Expect = 4e-32
Identities = 103/454 (22%), Positives = 201/454 (44%), Gaps = 33/454 (7%)
Query: 6 PYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLI 65
PY I L L TI GN LV++++ +R L+ N FL SLA AD+++
Sbjct: 17 PYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFS 76
Query: 66 IPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRT 125
+ ++GYW C+++LALD + +S+++L IS DRY+ V++ L Y KRT
Sbjct: 77 MNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRT 136
Query: 126 PRRIKCIILTVWLIAAVISLPPLIY-KGDQGPQPRGRPQCKLN--QEAWYILASSIGSFF 182
+ +I W+++ ++ P +++ + G + +C + A ++I +F+
Sbjct: 137 TKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 183 APCLIMILVYLRIYLIAK---RSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALAS 239
P +IM ++Y I +K + +++ P A P Q R P +
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGR---------IVKPNNNN 247
Query: 240 VASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEE 299
+ S+ + H+K + G+ P D T ++ V +DE +
Sbjct: 248 MPSSDDGLEHNKI----QNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQ 303
Query: 300 EE----------EEEEEEEECEPQAVPVSPASACSP--PLQQPQGSRVLATLRGQVLLGR 347
+E ++E ++ C + +C+P + GS Q ++ R
Sbjct: 304 DENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVAR 363
Query: 348 GVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGL 407
+ + Q +++ +REK+ T + ++ F++ W P+ + C C +P+ +
Sbjct: 364 KIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAP-C-IPNTV 421
Query: 408 FQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441
+ +W+ Y NS++NP Y + N F++ F+ +L
Sbjct: 422 WTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 136 bits (342), Expect = 4e-32
Identities = 103/454 (22%), Positives = 201/454 (44%), Gaps = 33/454 (7%)
Query: 6 PYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLI 65
PY I L L TI GN LV++++ +R L+ N FL SLA AD+++
Sbjct: 17 PYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFS 76
Query: 66 IPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRT 125
+ ++GYW C+++LALD + +S+++L IS DRY+ V++ L Y KRT
Sbjct: 77 MNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRT 136
Query: 126 PRRIKCIILTVWLIAAVISLPPLIY-KGDQGPQPRGRPQCKLN--QEAWYILASSIGSFF 182
+ +I W+++ ++ P +++ + G + +C + A ++I +F+
Sbjct: 137 TKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 183 APCLIMILVYLRIYLIAK---RSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALAS 239
P +IM ++Y I +K + +++ P A P Q R P +
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGR---------IVKPNNNN 247
Query: 240 VASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEE 299
+ S+ + H+K + G+ P D T ++ V +DE +
Sbjct: 248 MPSSDDGLEHNKI----QNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQ 303
Query: 300 EE----------EEEEEEEECEPQAVPVSPASACSP--PLQQPQGSRVLATLRGQVLLGR 347
+E ++E ++ C + +C+P + GS Q ++ R
Sbjct: 304 DENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVAR 363
Query: 348 GVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGL 407
+ + Q +++ +REK+ T + ++ F++ W P+ + C C +P+ +
Sbjct: 364 KIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAP-C-IPNTV 421
Query: 408 FQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441
+ +W+ Y NS++NP Y + N F++ F+ +L
Sbjct: 422 WTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 136 bits (342), Expect = 4e-32
Identities = 103/454 (22%), Positives = 201/454 (44%), Gaps = 33/454 (7%)
Query: 6 PYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLI 65
PY I L L TI GN LV++++ +R L+ N FL SLA AD+++
Sbjct: 17 PYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFS 76
Query: 66 IPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRT 125
+ ++GYW C+++LALD + +S+++L IS DRY+ V++ L Y KRT
Sbjct: 77 MNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRT 136
Query: 126 PRRIKCIILTVWLIAAVISLPPLIY-KGDQGPQPRGRPQCKLN--QEAWYILASSIGSFF 182
+ +I W+++ ++ P +++ + G + +C + A ++I +F+
Sbjct: 137 TKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 183 APCLIMILVYLRIYLIAK---RSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALAS 239
P +IM ++Y I +K + +++ P A P Q R P +
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGR---------IVKPNNNN 247
Query: 240 VASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEE 299
+ S+ + H+K + G+ P D T ++ V +DE +
Sbjct: 248 MPSSDDGLEHNKI----QNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQ 303
Query: 300 EE----------EEEEEEEECEPQAVPVSPASACSP--PLQQPQGSRVLATLRGQVLLGR 347
+E ++E ++ C + +C+P + GS Q ++ R
Sbjct: 304 DENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVAR 363
Query: 348 GVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGL 407
+ + Q +++ +REK+ T + ++ F++ W P+ + C C +P+ +
Sbjct: 364 KIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAP-C-IPNTV 421
Query: 408 FQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441
+ +W+ Y NS++NP Y + N F++ F+ +L
Sbjct: 422 WTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 136 bits (342), Expect = 4e-32
Identities = 103/454 (22%), Positives = 201/454 (44%), Gaps = 33/454 (7%)
Query: 6 PYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLI 65
PY I L L TI GN LV++++ +R L+ N FL SLA AD+++
Sbjct: 17 PYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFS 76
Query: 66 IPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRT 125
+ ++GYW C+++LALD + +S+++L IS DRY+ V++ L Y KRT
Sbjct: 77 MNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRT 136
Query: 126 PRRIKCIILTVWLIAAVISLPPLIY-KGDQGPQPRGRPQCKLN--QEAWYILASSIGSFF 182
+ +I W+++ ++ P +++ + G + +C + A ++I +F+
Sbjct: 137 TKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 183 APCLIMILVYLRIYLIAK---RSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALAS 239
P +IM ++Y I +K + +++ P A P Q R P +
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGR---------IVKPNNNN 247
Query: 240 VASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEE 299
+ S+ + H+K + G+ P D T ++ V +DE +
Sbjct: 248 MPSSDDGLEHNKI----QNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQ 303
Query: 300 EE----------EEEEEEEECEPQAVPVSPASACSP--PLQQPQGSRVLATLRGQVLLGR 347
+E ++E ++ C + +C+P + GS Q ++ R
Sbjct: 304 DENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVAR 363
Query: 348 GVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGL 407
+ + Q +++ +REK+ T + ++ F++ W P+ + C C +P+ +
Sbjct: 364 KIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAP-C-IPNTV 421
Query: 408 FQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441
+ +W+ Y NS++NP Y + N F++ F+ +L
Sbjct: 422 WTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 136 bits (342), Expect = 4e-32
Identities = 103/454 (22%), Positives = 201/454 (44%), Gaps = 33/454 (7%)
Query: 6 PYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLI 65
PY I L L TI GN LV++++ +R L+ N FL SLA AD+++
Sbjct: 17 PYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFS 76
Query: 66 IPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRT 125
+ ++GYW C+++LALD + +S+++L IS DRY+ V++ L Y KRT
Sbjct: 77 MNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRT 136
Query: 126 PRRIKCIILTVWLIAAVISLPPLIY-KGDQGPQPRGRPQCKLN--QEAWYILASSIGSFF 182
+ +I W+++ ++ P +++ + G + +C + A ++I +F+
Sbjct: 137 TKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
Query: 183 APCLIMILVYLRIYLIAK---RSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALAS 239
P +IM ++Y I +K + +++ P A P Q R P +
Sbjct: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGR---------IVKPNNNN 247
Query: 240 VASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEE 299
+ S+ + H+K + G+ P D T ++ V +DE +
Sbjct: 248 MPSSDDGLEHNKI----QNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQ 303
Query: 300 EE----------EEEEEEEECEPQAVPVSPASACSP--PLQQPQGSRVLATLRGQVLLGR 347
+E ++E ++ C + +C+P + GS Q ++ R
Sbjct: 304 DENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVAR 363
Query: 348 GVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGL 407
+ + Q +++ +REK+ T + ++ F++ W P+ + C C +P+ +
Sbjct: 364 KIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAP-C-IPNTV 421
Query: 408 FQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441
+ +W+ Y NS++NP Y + N F++ F+ +L
Sbjct: 422 WTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,143,421
Number of Sequences: 37866
Number of extensions: 1007596
Number of successful extensions: 22364
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 914
Number of HSP's successfully gapped in prelim test: 496
Number of HSP's that attempted gapping in prelim test: 11978
Number of HSP's gapped (non-prelim): 5620
length of query: 450
length of database: 18,247,518
effective HSP length: 106
effective length of query: 344
effective length of database: 14,233,722
effective search space: 4896400368
effective search space used: 4896400368
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.