Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 33598944
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33598944 polycystic kidney disease 2-like 1 [Homo sapiens]
(805 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33598944 polycystic kidney disease 2-like 1 [Homo sapiens] 1637 0.0
gi|4505835 polycystin 2 [Homo sapiens] 771 0.0
gi|116812588 polycystic kidney disease 2-like 2 [Homo sapiens] 566 e-161
gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens] 225 1e-58
gi|5174633 receptor for egg jelly-like protein precursor [Homo s... 128 2e-29
gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens] 110 4e-24
gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens] 110 4e-24
gi|239756622 PREDICTED: polycystic kidney disease 1-like 3 [Homo... 75 2e-13
gi|239751108 PREDICTED: polycystic kidney disease 1-like 3 [Homo... 75 2e-13
gi|239745596 PREDICTED: polycystin 1-like 3 [Homo sapiens] 75 2e-13
gi|31559825 polycystin 1-like 3 [Homo sapiens] 75 2e-13
gi|19923084 polycystin-1L1 [Homo sapiens] 74 7e-13
gi|194733735 transient receptor potential cation channel, subfam... 68 4e-11
gi|4507687 transient receptor potential cation channel, subfamil... 68 4e-11
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I... 63 1e-09
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I... 63 1e-09
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
>gi|33598944 polycystic kidney disease 2-like 1 [Homo sapiens]
Length = 805
Score = 1637 bits (4238), Expect = 0.0
Identities = 805/805 (100%), Positives = 805/805 (100%)
Query: 1 MNAVGSPEGQELQKLGSGAWDNPAYSGPPSPHGTLRVCTISSTGPLQPQPKKPEDEPQET 60
MNAVGSPEGQELQKLGSGAWDNPAYSGPPSPHGTLRVCTISSTGPLQPQPKKPEDEPQET
Sbjct: 1 MNAVGSPEGQELQKLGSGAWDNPAYSGPPSPHGTLRVCTISSTGPLQPQPKKPEDEPQET 60
Query: 61 AYRTQVSSCCLHICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYG 120
AYRTQVSSCCLHICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYG
Sbjct: 61 AYRTQVSSCCLHICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYG 120
Query: 121 MTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSL 180
MTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSL
Sbjct: 121 MTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSL 180
Query: 181 GHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPFGPF 240
GHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPFGPF
Sbjct: 181 GHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPFGPF 240
Query: 241 NGTAWTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRV 300
NGTAWTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRV
Sbjct: 241 NGTAWTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRV 300
Query: 301 VFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFC 360
VFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFC
Sbjct: 301 VFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFC 360
Query: 361 VFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQ 420
VFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQ
Sbjct: 361 VFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQ 420
Query: 421 QPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGF 480
QPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGF
Sbjct: 421 QPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGF 480
Query: 481 AVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAY 540
AVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAY
Sbjct: 481 AVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAY 540
Query: 541 FVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKE 600
FVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKE
Sbjct: 541 FVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKE 600
Query: 601 RVSDVQKVLQGGEQEIQFEDFTNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEK 660
RVSDVQKVLQGGEQEIQFEDFTNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEK
Sbjct: 601 RVSDVQKVLQGGEQEIQFEDFTNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEK 660
Query: 661 MRQDLEEERVALNTEIEKLGRSIVSSPQGKSGPEAARAGGWVSGEEFYMLTRRVLQLETV 720
MRQDLEEERVALNTEIEKLGRSIVSSPQGKSGPEAARAGGWVSGEEFYMLTRRVLQLETV
Sbjct: 661 MRQDLEEERVALNTEIEKLGRSIVSSPQGKSGPEAARAGGWVSGEEFYMLTRRVLQLETV 720
Query: 721 LEGVVSQIDAVGSKLKMLERKGWLAPSPGVKEQAIWKHPQPAPAVTPDPWGVQGGQESEV 780
LEGVVSQIDAVGSKLKMLERKGWLAPSPGVKEQAIWKHPQPAPAVTPDPWGVQGGQESEV
Sbjct: 721 LEGVVSQIDAVGSKLKMLERKGWLAPSPGVKEQAIWKHPQPAPAVTPDPWGVQGGQESEV 780
Query: 781 PYKREEEALEERRLSRGEIPTLQRS 805
PYKREEEALEERRLSRGEIPTLQRS
Sbjct: 781 PYKREEEALEERRLSRGEIPTLQRS 805
>gi|4505835 polycystin 2 [Homo sapiens]
Length = 968
Score = 771 bits (1990), Expect = 0.0
Identities = 373/685 (54%), Positives = 509/685 (74%), Gaps = 22/685 (3%)
Query: 73 ICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKV 132
+ +G+RGLWGT L E ++ NRE Y+K+ LREL+ Y++FL+ +C+LTYGM SS+ YYYT++
Sbjct: 193 LVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRM 252
Query: 133 MSELFLHTP--SDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSLGHGSHSFIYY 190
MS+LFL TP +F+ +SSM DFW F +G LLD LYW +NQ+ + SFI+Y
Sbjct: 253 MSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEAD-NRSFIFY 311
Query: 191 ENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPFGPFNGTAWTYHSQ 250
EN+LLGVPR+RQL+VRN SC + +D R++I CYDVYS E++ PFGP NGTAW Y S+
Sbjct: 312 ENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSE 371
Query: 251 DELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNA 310
+L G SHWG + +YSG GYYLDL +R+ +A + +L++ +WLDRGTR FIDFSVYNA
Sbjct: 372 KDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNA 431
Query: 311 NINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEE 370
NINLFCV+RL+VEFPATGG IPSWQ + +KLIRYV+ +DFF+ CE+IFC FIFYYVVEE
Sbjct: 432 NINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEE 491
Query: 371 ILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEF 430
ILE+ IH+L Y S WN LD+V+++LS+VA+G +I+RT V L+ + L+ NT+ +FE
Sbjct: 492 ILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLL-QFLEDQNTFPNFEH 550
Query: 431 LAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFA 490
LA+WQ Q+NN+ AV +FF WIK+FK+I+FN+TM+QLS+T++RCAKD+ GFA+MFFI+F A
Sbjct: 551 LAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLA 610
Query: 491 YAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFF 550
YAQL YL+FGTQV++FSTF +CIFTQFRIILGD ++ I+ ANR+LGP YF T+VFF+FF
Sbjct: 611 YAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFF 670
Query: 551 VLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQ 610
+LLNMFLAIINDTYSEVK +LA QK E++LSDL+++GY+K L++L+L+K V D+ + L+
Sbjct: 671 ILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLR 730
Query: 611 GGEQEIQFEDFTNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEKMRQDLEEERV 670
G ++ F++ L+ GH + E+ A FTK+D+DG++ L E E ++MR DLE+ER
Sbjct: 731 QGGGKLNFDELRQDLKGKGHTD---AEIEAIFTKYDQDGDQELTEHEHQQMRDDLEKERE 787
Query: 671 ALNTEIEKLGRSIVS------------SPQGKSGPEAARAGGWVSG---EEFYMLTRRVL 715
L+ + L R + S SG + R G SG EEF +L RRV
Sbjct: 788 DLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVD 847
Query: 716 QLETVLEGVVSQIDAVGSKLKMLER 740
++E + +VS+IDAV KL+++ER
Sbjct: 848 RMEHSIGSIVSKIDAVIVKLEIMER 872
>gi|116812588 polycystic kidney disease 2-like 2 [Homo sapiens]
Length = 613
Score = 566 bits (1458), Expect = e-161
Identities = 277/547 (50%), Positives = 379/547 (69%), Gaps = 12/547 (2%)
Query: 93 RELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHT--PSDTGVSFQA 150
+E+ I TTL+ELL+Y +FL+++C+LT+GM + YY KVMS LFL T P + +F++
Sbjct: 21 KEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFKS 80
Query: 151 ISSMADFWDFAQGPLLDSLYWTKWYNNQSLGHGSHSF-IYYENMLLGVPRLRQLKVRNDS 209
I S+ DFW F +GPLL+ LYW WYNNQ L + +S IYYEN+LLGVPR+RQLKVRN++
Sbjct: 81 IRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNT 140
Query: 210 CVVHEDFREDILSCYDVYSPDKEEQLPFGPFNGTAWTYHSQDELGGFSHWGRLTSYSGGG 269
C V+ F+ + CY Y+ E+ FG T W Y + + + HWG L Y GG
Sbjct: 141 CKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPW-HWGFLGVYRNGG 199
Query: 270 YYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGG 329
Y L S+ + L+ W+ RGTRV+FIDFS+YNAN+NLFC++RLV EFPATGG
Sbjct: 200 YIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGG 259
Query: 330 AIPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHRLRYLSSIWNIL 389
+ SWQ +VKL+RYVS +D+FI CE+ FC+F+F + +E+ ++ + Y SIWN L
Sbjct: 260 ILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWL 319
Query: 390 DLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFA 449
+L+++LL VAV F+ + +++ L+G+LL+ Y+DF FLA W YNN+ A+ +FFA
Sbjct: 320 ELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFA 379
Query: 450 WIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVENFSTF 509
WIKIFK+ISFNKTM+QLSSTL+RC KDI+GFA+MFFI+FFAYAQLG+L+FG+QV++FSTF
Sbjct: 380 WIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVDDFSTF 439
Query: 510 IKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKE 569
IF QFRI+LGDF++ I AN ILGP YF+T++FFVFFVLLNMFLAIINDTYSEVK
Sbjct: 440 QNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKA 499
Query: 570 ELA-GQKDELQLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQGGEQEIQFEDFTNTLREL 628
+ + G++ + +L ++KQ Y L + RL+K + + +K G D R
Sbjct: 500 DYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSG-------DLAEQARRE 552
Query: 629 GHAEHEI 635
G E+EI
Sbjct: 553 GFDENEI 559
>gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens]
Length = 2459
Score = 225 bits (574), Expect = 1e-58
Identities = 137/488 (28%), Positives = 241/488 (49%), Gaps = 22/488 (4%)
Query: 101 LRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDF 160
+RE+L Y+ FL + L+ YG SAY+ + + F F + +F+ +
Sbjct: 1948 IREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQHSFTR-------GFSGVLGFREFFKW 2000
Query: 161 AQGPLLDSLYWTKWYNNQSLGHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDI 220
A L+ +LY GH + L+G ++RQ++V+ SC + + + +
Sbjct: 2001 ANTTLVSNLY----------GHPPGFITDGNSKLVGSAQIRQVRVQESSCPLAQQPQAYL 2050
Query: 221 LSCYDVYSPDKEEQLPFGP-FNGTA---WTYHSQDELGGFSHWGRLTSYSGGGYYLDLPG 276
C YS D E+ +G +N T W Y SQD+ G+ WG+LT Y GGGY + L
Sbjct: 2051 NGCRAPYSLDAEDMADYGEGWNATTLSEWQYQSQDQRQGYPIWGKLTVYRGGGYVVPLGT 2110
Query: 277 SRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQI 336
RQ ++ LR L + WLD TR VF++ +VYNAN+NLFC++ L +E A G +
Sbjct: 2111 DRQSTSRILRYLFDNTWLDALTRAVFVESTVYNANVNLFCIVTLTLETSALGTFFTHAAL 2170
Query: 337 RTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILL 396
++++L + W F+V E+I+ +F+ YY+V + + Y S WN+L+L +IL
Sbjct: 2171 QSLRLYPFTDGWHPFVVAAELIYFLFLLYYMVVQGKRMSKETWGYFCSKWNLLELAIILA 2230
Query: 397 SIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKY 456
S A+ + R + R + + F A + A + + +K++
Sbjct: 2231 SWSALAVFVKRAVLAERDLQRCRNHREEGISFSETAAADAALGYIIAFLVLLSTVKLWHL 2290
Query: 457 ISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQ 516
+ N M +++ L R DI GF ++ + AY+ L+FG ++ ++ T T
Sbjct: 2291 LRLNPKMNMITAALRRAWGDISGFMIVILTMLLAYSIASNLIFGWKLRSYKTLFDAAETM 2350
Query: 517 FRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKD 576
+ LG F+Y + + + +LG + + F+ FV+LN+F+++I +SE +++ +
Sbjct: 2351 VSLQLGIFNYEEVLDYSPVLGSFLIGSCIVFMTFVVLNLFISVILVAFSE-EQKYYQLSE 2409
Query: 577 ELQLSDLL 584
E ++ DLL
Sbjct: 2410 EGEIVDLL 2417
>gi|5174633 receptor for egg jelly-like protein precursor [Homo
sapiens]
Length = 2253
Score = 128 bits (321), Expect = 2e-29
Identities = 111/488 (22%), Positives = 199/488 (40%), Gaps = 37/488 (7%)
Query: 101 LRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDF 160
L +L + +FL + +L + + +YY + + + F + ++ + D + +
Sbjct: 1711 LSYILTHFIFLALLLILIVLLRHTDCFYYNQFIRDRF-------SMDLATVTKLEDIYRW 1763
Query: 161 AQGPLLDSLYWTKWYNNQSLGHGSHSFIYYENMLLGVPRLRQLKVRNDS--CVVHEDFRE 218
LL L+ N L S + +LG+P +RQ++ ++ C+ E F +
Sbjct: 1764 LNSVLLPLLH--NDLNPTFLPESS-------SKILGLPLMRQVRAKSSEKMCLPAEKFVQ 1814
Query: 219 DILS----CYDVYSPDKEEQLPFGPF-----------NGTAWTYHSQDELGGFSHWGRLT 263
+ + C+ Y D E+ + F + +TY Q + +G L
Sbjct: 1815 NSIRREIHCHPKYGIDPEDTKNYSGFWNEVDKQAIDESTNGFTYKPQGTQWLYYSYGLLH 1874
Query: 264 SYSGGGY--YLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLV 321
+Y GGY Y R S L+ LQE WLD T V ++ + +N +INLFC + ++
Sbjct: 1875 TYGSGGYALYFFPEQQRFNSTLRLKELQESNWLDEKTWAVVLELTTFNPDINLFCSISVI 1934
Query: 322 VEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHRLRY 381
E G S + + L + I V +F YVV+E + R Y
Sbjct: 1935 FEVSQLGVVNTSISLHSFSLADFDRKASAEIY-LYVAILIFFLAYVVDEGCIIMQERASY 1993
Query: 382 LSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQYNNM 441
+ S++N+L+ + + V + + + ++ L P + F ++ +
Sbjct: 1994 VRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIRFYLSNPEDFIPFHAVSQVDHIMRII 2053
Query: 442 NAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGT 501
LF +K +Y F + + I A + + FF Y GYL+FG
Sbjct: 2054 LGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMAFVVSVYFFVYMAFGYLVFGQ 2113
Query: 502 QVENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIIN 561
N+S I T F + F N NRILG + +++ + VL+N+F A+I
Sbjct: 2114 HEWNYSNLIHSTQTVFSYCVSAFQNTEFSN-NRILGVLFLSSFMLVMICVLINLFQAVIL 2172
Query: 562 DTYSEVKE 569
Y E+K+
Sbjct: 2173 SAYEEMKQ 2180
>gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens]
Length = 4302
Score = 110 bits (276), Expect = 4e-24
Identities = 105/413 (25%), Positives = 180/413 (43%), Gaps = 37/413 (8%)
Query: 101 LRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDF 160
LR LLVY++FL+ L +YG S + Y ++ S + S +F AI+ + W +
Sbjct: 3670 LRSLLVYMLFLLVTLLASYGDASCHGHAY-RLQSAIKQELHSR---AFLAITRSEELWPW 3725
Query: 161 AQGPLLDSLYWTKWYNNQSLGHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDI 220
LL + HG+ S + LG PRLRQ++++ R
Sbjct: 3726 MAHVLLPYV------------HGNQS-----SPELGPPRLRQVRLQEALYPDPPGPRVHT 3768
Query: 221 LSCYDVYSPDKEEQLPFGPFNGTA-WTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQ 279
S +S + P NG+ W Y + D LG +S WG Y GGY +L S +
Sbjct: 3769 CSAAGGFSTSDYDVGWESPHNGSGTWAYSAPDLLGAWS-WGSCAVYDSGGYVQELGLSLE 3827
Query: 280 GSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTV 339
S + LR LQ WLD +R VF++ + Y+ + L + L +EFPA G A+ + +R
Sbjct: 3828 ESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLEFPAAGRALAALSVRPF 3887
Query: 340 KLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHRLRYLSSIWNILDL------VV 393
L R + ++ V +F ++ V E R + W +L L ++
Sbjct: 3888 ALRRLSAGLSLPLL-TSVCLLLFAVHFAVAEA------RTWHREGRWRVLRLGAWARWLL 3940
Query: 394 ILLSIVAVGFHIFRTLEVNRLMGKLLQ-QPNTYADFEFLAFWQTQYNNMNAVNLFFAWIK 452
+ L+ + + +R + ++ +P + F+ +A + + A LF +K
Sbjct: 3941 VALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARGLAASLLFLLLVK 4000
Query: 453 IFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVEN 505
+ + F + + TL R ++LG + ++ AYAQL LL + V++
Sbjct: 4001 AAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVDS 4053
>gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens]
Length = 4303
Score = 110 bits (276), Expect = 4e-24
Identities = 105/413 (25%), Positives = 180/413 (43%), Gaps = 37/413 (8%)
Query: 101 LRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDF 160
LR LLVY++FL+ L +YG S + Y ++ S + S +F AI+ + W +
Sbjct: 3671 LRSLLVYMLFLLVTLLASYGDASCHGHAY-RLQSAIKQELHSR---AFLAITRSEELWPW 3726
Query: 161 AQGPLLDSLYWTKWYNNQSLGHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDI 220
LL + HG+ S + LG PRLRQ++++ R
Sbjct: 3727 MAHVLLPYV------------HGNQS-----SPELGPPRLRQVRLQEALYPDPPGPRVHT 3769
Query: 221 LSCYDVYSPDKEEQLPFGPFNGTA-WTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQ 279
S +S + P NG+ W Y + D LG +S WG Y GGY +L S +
Sbjct: 3770 CSAAGGFSTSDYDVGWESPHNGSGTWAYSAPDLLGAWS-WGSCAVYDSGGYVQELGLSLE 3828
Query: 280 GSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTV 339
S + LR LQ WLD +R VF++ + Y+ + L + L +EFPA G A+ + +R
Sbjct: 3829 ESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLEFPAAGRALAALSVRPF 3888
Query: 340 KLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHRLRYLSSIWNILDL------VV 393
L R + ++ V +F ++ V E R + W +L L ++
Sbjct: 3889 ALRRLSAGLSLPLL-TSVCLLLFAVHFAVAEA------RTWHREGRWRVLRLGAWARWLL 3941
Query: 394 ILLSIVAVGFHIFRTLEVNRLMGKLLQ-QPNTYADFEFLAFWQTQYNNMNAVNLFFAWIK 452
+ L+ + + +R + ++ +P + F+ +A + + A LF +K
Sbjct: 3942 VALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARGLAASLLFLLLVK 4001
Query: 453 IFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVEN 505
+ + F + + TL R ++LG + ++ AYAQL LL + V++
Sbjct: 4002 AAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVDS 4054
>gi|239756622 PREDICTED: polycystic kidney disease 1-like 3 [Homo
sapiens]
Length = 1732
Score = 75.1 bits (183), Expect = 2e-13
Identities = 54/242 (22%), Positives = 112/242 (46%), Gaps = 13/242 (5%)
Query: 356 EVIFCVFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLM 415
+VI+ + + YY + +L + R+ + NILD +IL+S + +G + + M
Sbjct: 1470 QVIYYLLVCYYAFIQGCQLKQQKWRFFTGKRNILDTSIILISFILLGLDMKSISLHKKNM 1529
Query: 416 GKLLQQPNTYADFEFLAFWQTQYNNMNAVNL-----FFAWIKIFKYISFNKTMTQLSSTL 470
+ + F++F++ N A +L A ++++ + + + +S TL
Sbjct: 1530 ARYRDDQD-----RFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTL 1584
Query: 471 ARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAID 530
+R +++GF ++ I+ YA LLFG + ++ TF T +++G +
Sbjct: 1585 SRAWDEVVGFLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVF 1644
Query: 531 NANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNK 590
+ +LG +T V + V++N+F++ I + + ++ L K E L D L Q +
Sbjct: 1645 ALDPVLGTFLILTSVILMVLVVINLFVSAILMAFGKERKSL---KKEAALIDTLLQKLSN 1701
Query: 591 TL 592
L
Sbjct: 1702 LL 1703
Score = 34.7 bits (78), Expect = 0.36
Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 9/84 (10%)
Query: 87 ENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGV 146
E T + ++L+ T ++LV I+FL + Y +S+ +Y + + + F H
Sbjct: 1270 ERTLKKKKLFKLTG--DILVQILFLTLLMTAIYSAKNSNRFYLHQAIWKTFSH------- 1320
Query: 147 SFQAISSMADFWDFAQGPLLDSLY 170
F I + DF+ +A LL SLY
Sbjct: 1321 QFSEIKLLQDFYPWANHILLPSLY 1344
>gi|239751108 PREDICTED: polycystic kidney disease 1-like 3 [Homo
sapiens]
Length = 1731
Score = 75.1 bits (183), Expect = 2e-13
Identities = 54/242 (22%), Positives = 112/242 (46%), Gaps = 13/242 (5%)
Query: 356 EVIFCVFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLM 415
+VI+ + + YY + +L + R+ + NILD +IL+S + +G + + M
Sbjct: 1469 QVIYYLLVCYYAFIQGCQLKQQKWRFFTGKRNILDTSIILISFILLGLDMKSISLHKKNM 1528
Query: 416 GKLLQQPNTYADFEFLAFWQTQYNNMNAVNL-----FFAWIKIFKYISFNKTMTQLSSTL 470
+ + F++F++ N A +L A ++++ + + + +S TL
Sbjct: 1529 ARYRDDQD-----RFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTL 1583
Query: 471 ARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAID 530
+R +++GF ++ I+ YA LLFG + ++ TF T +++G +
Sbjct: 1584 SRAWDEVVGFLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVF 1643
Query: 531 NANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNK 590
+ +LG +T V + V++N+F++ I + + ++ L K E L D L Q +
Sbjct: 1644 ALDPVLGTFLILTSVILMVLVVINLFVSAILMAFGKERKSL---KKEAALIDTLLQKLSN 1700
Query: 591 TL 592
L
Sbjct: 1701 LL 1702
Score = 34.7 bits (78), Expect = 0.36
Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 9/84 (10%)
Query: 87 ENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGV 146
E T + ++L+ T ++LV I+FL + Y +S+ +Y + + + F H
Sbjct: 1269 ERTLKKKKLFKLTG--DILVQILFLTLLMTAIYSAKNSNRFYLHQAIWKTFSH------- 1319
Query: 147 SFQAISSMADFWDFAQGPLLDSLY 170
F I + DF+ +A LL SLY
Sbjct: 1320 QFSEIKLLQDFYPWANHILLPSLY 1343
>gi|239745596 PREDICTED: polycystin 1-like 3 [Homo sapiens]
Length = 1731
Score = 75.1 bits (183), Expect = 2e-13
Identities = 54/242 (22%), Positives = 112/242 (46%), Gaps = 13/242 (5%)
Query: 356 EVIFCVFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLM 415
+VI+ + + YY + +L + R+ + NILD +IL+S + +G + + M
Sbjct: 1469 QVIYYLLVCYYAFIQGCQLKQQKWRFFTGKRNILDTSIILISFILLGLDMKSISLHKKNM 1528
Query: 416 GKLLQQPNTYADFEFLAFWQTQYNNMNAVNL-----FFAWIKIFKYISFNKTMTQLSSTL 470
+ + F++F++ N A +L A ++++ + + + +S TL
Sbjct: 1529 ARYRDDQD-----RFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTL 1583
Query: 471 ARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAID 530
+R +++GF ++ I+ YA LLFG + ++ TF T +++G +
Sbjct: 1584 SRAWDEVVGFLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVF 1643
Query: 531 NANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNK 590
+ +LG +T V + V++N+F++ I + + ++ L K E L D L Q +
Sbjct: 1644 ALDPVLGTFLILTSVILMVLVVINLFVSAILMAFGKERKSL---KKEAALIDTLLQKLSN 1700
Query: 591 TL 592
L
Sbjct: 1701 LL 1702
Score = 34.7 bits (78), Expect = 0.36
Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 9/84 (10%)
Query: 87 ENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGV 146
E T + ++L+ T ++LV I+FL + Y +S+ +Y + + + F H
Sbjct: 1269 ERTLKKKKLFKLTG--DILVQILFLTLLMTAIYSAKNSNRFYLHQAIWKTFSH------- 1319
Query: 147 SFQAISSMADFWDFAQGPLLDSLY 170
F I + DF+ +A LL SLY
Sbjct: 1320 QFSEIKLLQDFYPWANHILLPSLY 1343
>gi|31559825 polycystin 1-like 3 [Homo sapiens]
Length = 1732
Score = 75.1 bits (183), Expect = 2e-13
Identities = 54/242 (22%), Positives = 112/242 (46%), Gaps = 13/242 (5%)
Query: 356 EVIFCVFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLM 415
+VI+ + + YY + +L + R+ + NILD +IL+S + +G + + M
Sbjct: 1470 QVIYYLLVCYYAFIQGCQLKQQKWRFFTGKRNILDTSIILISFILLGLDMKSISLHKKNM 1529
Query: 416 GKLLQQPNTYADFEFLAFWQTQYNNMNAVNL-----FFAWIKIFKYISFNKTMTQLSSTL 470
+ + F++F++ N A +L A ++++ + + + +S TL
Sbjct: 1530 ARYRDDQD-----RFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTL 1584
Query: 471 ARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAID 530
+R +++GF ++ I+ YA LLFG + ++ TF T +++G +
Sbjct: 1585 SRAWDEVVGFLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVF 1644
Query: 531 NANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNK 590
+ +LG +T V + V++N+F++ I + + ++ L K E L D L Q +
Sbjct: 1645 ALDPVLGTFLILTSVILMVLVVINLFVSAILMAFGKERKSL---KKEAALIDTLLQKLSN 1701
Query: 591 TL 592
L
Sbjct: 1702 LL 1703
Score = 34.7 bits (78), Expect = 0.36
Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 9/84 (10%)
Query: 87 ENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGV 146
E T + ++L+ T ++LV I+FL + Y +S+ +Y + + + F H
Sbjct: 1270 ERTLKKKKLFKLTG--DILVQILFLTLLMTAIYSAKNSNRFYLHQAIWKTFSH------- 1320
Query: 147 SFQAISSMADFWDFAQGPLLDSLY 170
F I + DF+ +A LL SLY
Sbjct: 1321 QFSEIKLLQDFYPWANHILLPSLY 1344
>gi|19923084 polycystin-1L1 [Homo sapiens]
Length = 2849
Score = 73.6 bits (179), Expect = 7e-13
Identities = 121/556 (21%), Positives = 211/556 (37%), Gaps = 52/556 (9%)
Query: 93 RELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGVSFQAIS 152
RE + LR++ + I+ L+ + + YG S Y + + + F + +
Sbjct: 2276 RESRTRAALRDISMDILMLLLLLCVIYGRFSQDEYSLNQAIRKEFTRNARNC---LGGLR 2332
Query: 153 SMADFWDFAQGPLLDSLYWTKWYNNQSLGHGSHSFIYYENMLLGVPRLRQLKV-RNDSCV 211
++AD+WD++ LLD LY + + G + + L+G +RQLKV C
Sbjct: 2333 NIADWWDWSLTTLLDGLYPGGTPSARVPG-AQPGALGGKCYLIGSSVIRQLKVFPRHLCK 2391
Query: 212 VHEDFREDILSCYDVYSPDKEEQLPFGPFNGTAWTYHSQD-ELGGFSHWGRLTSYSGGGY 270
F I SP+ GP N +Q+ L G G
Sbjct: 2392 PPRPFSALIEDSIPTCSPEVG-----GPENPYLIDPENQNVTLNGPGGCGTREDC----- 2441
Query: 271 YLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGGA 330
L L +R + AL L+ +W+DR TR V + F++YN LF + L VE TG
Sbjct: 2442 VLSLGRTRTEAHTALSRLRASMWIDRSTRAVSVHFTLYNPPTQLFTSVSLRVEILPTGSL 2501
Query: 331 IPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNIL 389
+PS + + + R S + ++ +++F ++ ++ + L Y N L
Sbjct: 2502 VPSSLVESFSIFRSDSALQYHLMLPQLVFLALSLIHLCVQLYRMMDKGVLSYWRKPRNWL 2561
Query: 390 DLVVILLSIV--AVGFHIFRTLEVNRLMGKLLQQ-----PNTYADFEFLAFWQTQYNNMN 442
+L V+ +S+ AV H+ L G + Q + D +A W + +
Sbjct: 2562 ELSVVGVSLTYYAVSGHLV------TLAGDVTNQFHRGLCRAFMDLTLMASWNQRARWLR 2615
Query: 443 AVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQ 502
+ LF +K TM SS + I ++ ++ A + L L
Sbjct: 2616 GILLFLFTLKCVYLPGIQNTMASCSSMMRHSLPSIFVAGLVGALMLAALSHLHRFLLSMW 2675
Query: 503 VENFSTFIKCIFTQFRIILGDFDYNA-------IDNANRILGPAYFVTYVFF---VFFVL 552
V TF F +L F + + +++ YF + + F +
Sbjct: 2676 VLPPGTFTDA----FPGLLFHFPRRSQKDCLLGLSKSDQRAMACYFGILLIVSATLCFGM 2731
Query: 553 LNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQGG 612
L FL + K + K ++L D+ + K L LRL ++ + + V
Sbjct: 2732 LRGFLMTLPQ-----KRKSFQSKSFVRLKDVTAYMWEKVLTFLRLETPKLEEAEMV---E 2783
Query: 613 EQEIQFEDFTNTLREL 628
++F N L EL
Sbjct: 2784 NHNYYLDEFANLLDEL 2799
>gi|194733735 transient receptor potential cation channel, subfamily
C, member 3 isoform a [Homo sapiens]
Length = 921
Score = 67.8 bits (164), Expect = 4e-11
Identities = 69/307 (22%), Positives = 133/307 (43%), Gaps = 56/307 (18%)
Query: 300 VVFIDFSVYNANINLFCVLRL----VVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGC 355
++F+ V+NA+ + L V ++P QI VK ++ W
Sbjct: 467 IIFLGLLVFNASDRFEGITTLPNITVTDYPK--------QIFRVKTTQFT--WT------ 510
Query: 356 EVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E++ V++ + E EL + R Y+ +WN+LD ++ + I A L+ +
Sbjct: 511 EMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKA 570
Query: 415 MGKL--------LQQPNTYADFEFLAFWQTQY---------NNMNAVNLFFAWIKIFKYI 457
+ L + + ++ + + ++ + A+ + ++ +I +
Sbjct: 571 QQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYIL 630
Query: 458 SFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLL------------FGTQVEN 505
N++ L +L R KDI F V+F +VFFA+ ++L F T E+
Sbjct: 631 PANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEES 690
Query: 506 FSTFIKCIF--TQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDT 563
F T IF ++ ++ +D+ I+N +L Y VT V VLLNM +A+IN +
Sbjct: 691 FKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMV----VVLLNMLIAMINSS 746
Query: 564 YSEVKEE 570
Y E++++
Sbjct: 747 YQEIEDD 753
>gi|4507687 transient receptor potential cation channel, subfamily
C, member 3 isoform b [Homo sapiens]
Length = 848
Score = 67.8 bits (164), Expect = 4e-11
Identities = 69/307 (22%), Positives = 133/307 (43%), Gaps = 56/307 (18%)
Query: 300 VVFIDFSVYNANINLFCVLRL----VVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGC 355
++F+ V+NA+ + L V ++P QI VK ++ W
Sbjct: 394 IIFLGLLVFNASDRFEGITTLPNITVTDYPK--------QIFRVKTTQFT--WT------ 437
Query: 356 EVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E++ V++ + E EL + R Y+ +WN+LD ++ + I A L+ +
Sbjct: 438 EMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKA 497
Query: 415 MGKL--------LQQPNTYADFEFLAFWQTQY---------NNMNAVNLFFAWIKIFKYI 457
+ L + + ++ + + ++ + A+ + ++ +I +
Sbjct: 498 QQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYIL 557
Query: 458 SFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLL------------FGTQVEN 505
N++ L +L R KDI F V+F +VFFA+ ++L F T E+
Sbjct: 558 PANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEES 617
Query: 506 FSTFIKCIF--TQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDT 563
F T IF ++ ++ +D+ I+N +L Y VT V VLLNM +A+IN +
Sbjct: 618 FKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMV----VVLLNMLIAMINSS 673
Query: 564 YSEVKEE 570
Y E++++
Sbjct: 674 YQEIEDD 680
>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform b [Homo sapiens]
Length = 2188
Score = 63.2 bits (152), Expect = 1e-09
Identities = 62/256 (24%), Positives = 105/256 (41%), Gaps = 58/256 (22%)
Query: 359 FCVFIF--YYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLM 415
+C ++F +V+E +L+L LR + WN LDL ++LLS++ + TLE +
Sbjct: 1486 YCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI------TLEEIEIN 1539
Query: 416 GKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAK 475
L P L ++ K + M L T+ +
Sbjct: 1540 AALPINPTIIRIMRVLRI-----------------ARVLKLLKMATGMRALLDTVVQALP 1582
Query: 476 DILGFAVMFFIVFFAYAQLGYLLFGTQVEN-------------FSTFIKCIFTQFRIILG 522
+ ++F ++FF YA LG LFG V N F F T F++ G
Sbjct: 1583 QVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTG 1642
Query: 523 D--------------FDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
D D + ++ + + P YFV++V FVL+N+ +A+ ++D+
Sbjct: 1643 DNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSN 1702
Query: 565 SEVKEELAGQKDELQL 580
E +E+ A EL+L
Sbjct: 1703 KEAQED-AEMDAELEL 1717
Score = 44.3 bits (103), Expect = 5e-04
Identities = 52/249 (20%), Positives = 101/249 (40%), Gaps = 52/249 (20%)
Query: 356 EVIFCVFIFYYVVEEILELHIHRL-RYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E IL+L L YL + +NI D +++++SI + V +
Sbjct: 638 EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEI---------VGQA 688
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 689 DGGL------------------------SVLRTFRLLRVLKLVRFMPALRRQLVVLMKTM 724
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV-------------ENFSTFIKCIFTQFRIIL 521
++ F ++ + F ++ LG +FG + +NF + + I T F+I+
Sbjct: 725 DNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILT 784
Query: 522 GDFDYNAI-DNANRILGP---AYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDE 577
+ D+N + N P YFV + F +VL N+ +AI+ + + + DE
Sbjct: 785 QE-DWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDE 843
Query: 578 LQLSDLLKQ 586
Q S +++
Sbjct: 844 DQSSSNIEE 852
Score = 32.7 bits (73), Expect = 1.4
Identities = 56/291 (19%), Positives = 100/291 (34%), Gaps = 87/291 (29%)
Query: 350 FFIVGCEVIFCVFIFYYVVEEI-LELHIHRLRYLSSIWNILDLVVILLSIVAV------- 401
F V + +F+ ++ + L L+ YL S WN+LD ++ +SI+ +
Sbjct: 1168 FLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASA 1227
Query: 402 -GFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFN 460
G I L V RL+ L + + IS
Sbjct: 1228 GGAKILGVLRVLRLLRTL---------------------------------RPLRVISRA 1254
Query: 461 KTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLF--------GTQVENFSTFIKC 512
+ + TL K I ++ F + LG LF G N + C
Sbjct: 1255 PGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDC 1314
Query: 513 IFTQFR------------------IILGDFD------YNAIDNANRILGPA--------- 539
+ +R +L D YN +D P
Sbjct: 1315 MAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLL 1374
Query: 540 YFVTYVFFVFFVLLNMFLAIINDTYSEVKE----ELAGQKDELQLSDLLKQ 586
YF++++ V F +LNMF+ ++ + + + ++ E A +++E +L L K+
Sbjct: 1375 YFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKK 1425
>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform a [Homo sapiens]
Length = 2223
Score = 63.2 bits (152), Expect = 1e-09
Identities = 62/256 (24%), Positives = 105/256 (41%), Gaps = 58/256 (22%)
Query: 359 FCVFIF--YYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLM 415
+C ++F +V+E +L+L LR + WN LDL ++LLS++ + TLE +
Sbjct: 1521 YCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI------TLEEIEIN 1574
Query: 416 GKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAK 475
L P L ++ K + M L T+ +
Sbjct: 1575 AALPINPTIIRIMRVLRI-----------------ARVLKLLKMATGMRALLDTVVQALP 1617
Query: 476 DILGFAVMFFIVFFAYAQLGYLLFGTQVEN-------------FSTFIKCIFTQFRIILG 522
+ ++F ++FF YA LG LFG V N F F T F++ G
Sbjct: 1618 QVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTG 1677
Query: 523 D--------------FDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
D D + ++ + + P YFV++V FVL+N+ +A+ ++D+
Sbjct: 1678 DNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSN 1737
Query: 565 SEVKEELAGQKDELQL 580
E +E+ A EL+L
Sbjct: 1738 KEAQED-AEMDAELEL 1752
Score = 44.3 bits (103), Expect = 5e-04
Identities = 52/249 (20%), Positives = 101/249 (40%), Gaps = 52/249 (20%)
Query: 356 EVIFCVFIFYYVVEEILELHIHRL-RYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E IL+L L YL + +NI D +++++SI + V +
Sbjct: 673 EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEI---------VGQA 723
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 724 DGGL------------------------SVLRTFRLLRVLKLVRFMPALRRQLVVLMKTM 759
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV-------------ENFSTFIKCIFTQFRIIL 521
++ F ++ + F ++ LG +FG + +NF + + I T F+I+
Sbjct: 760 DNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILT 819
Query: 522 GDFDYNAI-DNANRILGP---AYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDE 577
+ D+N + N P YFV + F +VL N+ +AI+ + + + DE
Sbjct: 820 QE-DWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDE 878
Query: 578 LQLSDLLKQ 586
Q S +++
Sbjct: 879 DQSSSNIEE 887
Score = 32.7 bits (73), Expect = 1.4
Identities = 56/291 (19%), Positives = 100/291 (34%), Gaps = 87/291 (29%)
Query: 350 FFIVGCEVIFCVFIFYYVVEEI-LELHIHRLRYLSSIWNILDLVVILLSIVAV------- 401
F V + +F+ ++ + L L+ YL S WN+LD ++ +SI+ +
Sbjct: 1203 FLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASA 1262
Query: 402 -GFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFN 460
G I L V RL+ L + + IS
Sbjct: 1263 GGAKILGVLRVLRLLRTL---------------------------------RPLRVISRA 1289
Query: 461 KTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLF--------GTQVENFSTFIKC 512
+ + TL K I ++ F + LG LF G N + C
Sbjct: 1290 PGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDC 1349
Query: 513 IFTQFR------------------IILGDFD------YNAIDNANRILGPA--------- 539
+ +R +L D YN +D P
Sbjct: 1350 MAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLL 1409
Query: 540 YFVTYVFFVFFVLLNMFLAIINDTYSEVKE----ELAGQKDELQLSDLLKQ 586
YF++++ V F +LNMF+ ++ + + + ++ E A +++E +L L K+
Sbjct: 1410 YFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKK 1460
>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
isoform 1 [Homo sapiens]
Length = 2377
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 58/266 (21%)
Query: 355 CEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNR 413
C IF V +V+E + +L R + WN LDL ++LLSI+ + TLE
Sbjct: 1646 CNYIFTVI---FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI------TLEEIE 1696
Query: 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
+ L P L ++ K + M L T+ +
Sbjct: 1697 VNASLPINPTIIRIMRVLRI-----------------ARVLKLLKMAVGMRALLDTVMQA 1739
Query: 474 AKDILGFAVMFFIVFFAYAQLGYLLFGT-------------QVENFSTFIKCIFTQFRII 520
+ ++F ++FF +A LG LFG + F F T FR+
Sbjct: 1740 LPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1799
Query: 521 LGDFDYNAIDNA------------NRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
GD ++N I N ++ P YFV++V FVL+N+ +A+ + ++
Sbjct: 1800 TGD-NWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1858
Query: 565 SEVKEELAGQKD-ELQLSDLLKQGYN 589
E KEE + + EL++ L Q ++
Sbjct: 1859 KEAKEEAELEAELELEMKTLSPQPHS 1884
Score = 40.8 bits (94), Expect = 0.005
Identities = 48/246 (19%), Positives = 102/246 (41%), Gaps = 55/246 (22%)
Query: 356 EVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E +L+L ++ Y+ + +NI D V++++S+ + V +
Sbjct: 776 EISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI---------VGQQ 826
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 827 GGGL------------------------SVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV------------ENFSTFIKCIFTQFRIILG 522
++ F ++ + F ++ LG LFG + +NF + + I T F+I+
Sbjct: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQ 922
Query: 523 DFDYNAI----DNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYS----EVKEELAGQ 574
+ D+N + + YF+ + F +VL N+ +AI+ + + +E+ +GQ
Sbjct: 923 E-DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQ 981
Query: 575 KDELQL 580
+QL
Sbjct: 982 LSCIQL 987
Score = 35.0 bits (79), Expect = 0.28
Identities = 55/265 (20%), Positives = 93/265 (35%), Gaps = 86/265 (32%)
Query: 381 YLSSIWNILDLVVILLSIVAV--------GFHIFRTLEVNRLMGKLLQQPNTYADFEFLA 432
YL S WN+LD +++L+S++ + G I L V RL+ L
Sbjct: 1341 YLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTL-------------- 1386
Query: 433 FWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA 492
+ + IS + + + TL K I V+ F +
Sbjct: 1387 -------------------RPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1427
Query: 493 QLGYLLF--------GTQVENFSTFIKCIFTQFRII--------LG-------------- 522
LG LF G N + C +R + LG
Sbjct: 1428 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1487
Query: 523 --DFDYNAIDNANRILGPA---------YFVTYVFFVFFVLLNMFLAIINDTYSEVK--- 568
D Y+ +D P YF++++ V F +LNMF+ ++ + + + +
Sbjct: 1488 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1547
Query: 569 -EELAGQKDELQLSDLLKQGYNKTL 592
EE A +++E +L L K+ N L
Sbjct: 1548 EEEEARRREEKRLRRLEKKRRNLML 1572
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 58/266 (21%)
Query: 355 CEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNR 413
C IF V +V+E + +L R + WN LDL ++LLSI+ + TLE
Sbjct: 1612 CNYIFTVI---FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI------TLEEIE 1662
Query: 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
+ L P L ++ K + M L T+ +
Sbjct: 1663 VNASLPINPTIIRIMRVLRI-----------------ARVLKLLKMAVGMRALLDTVMQA 1705
Query: 474 AKDILGFAVMFFIVFFAYAQLGYLLFGT-------------QVENFSTFIKCIFTQFRII 520
+ ++F ++FF +A LG LFG + F F T FR+
Sbjct: 1706 LPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1765
Query: 521 LGDFDYNAIDNA------------NRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
GD ++N I N ++ P YFV++V FVL+N+ +A+ + ++
Sbjct: 1766 TGD-NWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1824
Query: 565 SEVKEELAGQKD-ELQLSDLLKQGYN 589
E KEE + + EL++ L Q ++
Sbjct: 1825 KEAKEEAELEAELELEMKTLSPQPHS 1850
Score = 37.7 bits (86), Expect = 0.043
Identities = 43/222 (19%), Positives = 91/222 (40%), Gaps = 51/222 (22%)
Query: 356 EVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E +L+L ++ Y+ + +NI D V++++S+ + V +
Sbjct: 776 EISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI---------VGQQ 826
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 827 GGGL------------------------SVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV------------ENFSTFIKCIFTQFRIILG 522
++ F ++ + F ++ LG LFG + +NF + + I T F+I+
Sbjct: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQ 922
Query: 523 DFDYNAI----DNANRILGPAYFVTYVFFVFFVLLNMFLAII 560
+ D+N + + YF+ + F +VL N+ +AI+
Sbjct: 923 E-DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAIL 963
Score = 34.7 bits (78), Expect = 0.36
Identities = 54/263 (20%), Positives = 93/263 (35%), Gaps = 86/263 (32%)
Query: 381 YLSSIWNILDLVVILLSIVAV--------GFHIFRTLEVNRLMGKLLQQPNTYADFEFLA 432
YL S WN+LD +++L+S++ + G I L V RL+ L
Sbjct: 1318 YLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTL-------------- 1363
Query: 433 FWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA 492
+ + IS + + + TL K I V+ F +
Sbjct: 1364 -------------------RPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 493 QLGYLLF--------GTQVENFSTFIKCIFTQFRII--------LG-------------- 522
LG LF G N + C +R + LG
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 523 --DFDYNAIDNANRILGPA---------YFVTYVFFVFFVLLNMFLAIINDTYSEVK--- 568
D Y+ +D P YF++++ V F +LNMF+ ++ + + + +
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1524
Query: 569 -EELAGQKDELQLSDLLKQGYNK 590
EE A +++E +L L K+ +K
Sbjct: 1525 EEEEARRREEKRLRRLEKKRRSK 1547
>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
isoform 13 [Homo sapiens]
Length = 2243
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 58/266 (21%)
Query: 355 CEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNR 413
C IF V +V+E + +L R + WN LDL ++LLSI+ + TLE
Sbjct: 1605 CNYIFTVI---FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI------TLEEIE 1655
Query: 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
+ L P L ++ K + M L T+ +
Sbjct: 1656 VNASLPINPTIIRIMRVLRI-----------------ARVLKLLKMAVGMRALLDTVMQA 1698
Query: 474 AKDILGFAVMFFIVFFAYAQLGYLLFGT-------------QVENFSTFIKCIFTQFRII 520
+ ++F ++FF +A LG LFG + F F T FR+
Sbjct: 1699 LPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1758
Query: 521 LGDFDYNAIDNA------------NRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
GD ++N I N ++ P YFV++V FVL+N+ +A+ + ++
Sbjct: 1759 TGD-NWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1817
Query: 565 SEVKEELAGQKD-ELQLSDLLKQGYN 589
E KEE + + EL++ L Q ++
Sbjct: 1818 KEAKEEAELEAELELEMKTLSPQPHS 1843
Score = 37.7 bits (86), Expect = 0.043
Identities = 43/222 (19%), Positives = 91/222 (40%), Gaps = 51/222 (22%)
Query: 356 EVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E +L+L ++ Y+ + +NI D V++++S+ + V +
Sbjct: 776 EISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI---------VGQQ 826
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 827 GGGL------------------------SVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV------------ENFSTFIKCIFTQFRIILG 522
++ F ++ + F ++ LG LFG + +NF + + I T F+I+
Sbjct: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQ 922
Query: 523 DFDYNAI----DNANRILGPAYFVTYVFFVFFVLLNMFLAII 560
+ D+N + + YF+ + F +VL N+ +AI+
Sbjct: 923 E-DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAIL 963
Score = 33.9 bits (76), Expect = 0.62
Identities = 53/259 (20%), Positives = 91/259 (35%), Gaps = 86/259 (33%)
Query: 381 YLSSIWNILDLVVILLSIVAV--------GFHIFRTLEVNRLMGKLLQQPNTYADFEFLA 432
YL S WN+LD +++L+S++ + G I L V RL+ L
Sbjct: 1318 YLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTL-------------- 1363
Query: 433 FWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA 492
+ + IS + + + TL K I V+ F +
Sbjct: 1364 -------------------RPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 493 QLGYLLF--------GTQVENFSTFIKCIFTQFRII--------LG-------------- 522
LG LF G N + C +R + LG
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 523 --DFDYNAIDNANRILGPA---------YFVTYVFFVFFVLLNMFLAIINDTYSEVK--- 568
D Y+ +D P YF++++ V F +LNMF+ ++ + + + +
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1524
Query: 569 -EELAGQKDELQLSDLLKQ 586
EE A +++E +L L K+
Sbjct: 1525 EEEEARRREEKRLRRLEKK 1543
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 58/266 (21%)
Query: 355 CEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNR 413
C IF V +V+E + +L R + WN LDL ++LLSI+ + TLE
Sbjct: 1612 CNYIFTVI---FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI------TLEEIE 1662
Query: 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
+ L P L ++ K + M L T+ +
Sbjct: 1663 VNASLPINPTIIRIMRVLRI-----------------ARVLKLLKMAVGMRALLDTVMQA 1705
Query: 474 AKDILGFAVMFFIVFFAYAQLGYLLFGT-------------QVENFSTFIKCIFTQFRII 520
+ ++F ++FF +A LG LFG + F F T FR+
Sbjct: 1706 LPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1765
Query: 521 LGDFDYNAIDNA------------NRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
GD ++N I N ++ P YFV++V FVL+N+ +A+ + ++
Sbjct: 1766 TGD-NWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1824
Query: 565 SEVKEELAGQKD-ELQLSDLLKQGYN 589
E KEE + + EL++ L Q ++
Sbjct: 1825 KEAKEEAELEAELELEMKTLSPQPHS 1850
Score = 37.7 bits (86), Expect = 0.043
Identities = 43/222 (19%), Positives = 91/222 (40%), Gaps = 51/222 (22%)
Query: 356 EVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E +L+L ++ Y+ + +NI D V++++S+ + V +
Sbjct: 776 EISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI---------VGQQ 826
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 827 GGGL------------------------SVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV------------ENFSTFIKCIFTQFRIILG 522
++ F ++ + F ++ LG LFG + +NF + + I T F+I+
Sbjct: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQ 922
Query: 523 DFDYNAI----DNANRILGPAYFVTYVFFVFFVLLNMFLAII 560
+ D+N + + YF+ + F +VL N+ +AI+
Sbjct: 923 E-DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAIL 963
Score = 34.7 bits (78), Expect = 0.36
Identities = 54/263 (20%), Positives = 93/263 (35%), Gaps = 86/263 (32%)
Query: 381 YLSSIWNILDLVVILLSIVAV--------GFHIFRTLEVNRLMGKLLQQPNTYADFEFLA 432
YL S WN+LD +++L+S++ + G I L V RL+ L
Sbjct: 1318 YLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTL-------------- 1363
Query: 433 FWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA 492
+ + IS + + + TL K I V+ F +
Sbjct: 1364 -------------------RPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 493 QLGYLLF--------GTQVENFSTFIKCIFTQFRII--------LG-------------- 522
LG LF G N + C +R + LG
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 523 --DFDYNAIDNANRILGPA---------YFVTYVFFVFFVLLNMFLAIINDTYSEVK--- 568
D Y+ +D P YF++++ V F +LNMF+ ++ + + + +
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1524
Query: 569 -EELAGQKDELQLSDLLKQGYNK 590
EE A +++E +L L K+ +K
Sbjct: 1525 EEEEARRREEKRLRRLEKKRRSK 1547
>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
isoform 10 [Homo sapiens]
Length = 2266
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 58/266 (21%)
Query: 355 CEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNR 413
C IF V +V+E + +L R + WN LDL ++LLSI+ + TLE
Sbjct: 1628 CNYIFTVI---FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI------TLEEIE 1678
Query: 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
+ L P L ++ K + M L T+ +
Sbjct: 1679 VNASLPINPTIIRIMRVLRI-----------------ARVLKLLKMAVGMRALLDTVMQA 1721
Query: 474 AKDILGFAVMFFIVFFAYAQLGYLLFGT-------------QVENFSTFIKCIFTQFRII 520
+ ++F ++FF +A LG LFG + F F T FR+
Sbjct: 1722 LPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1781
Query: 521 LGDFDYNAIDNA------------NRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
GD ++N I N ++ P YFV++V FVL+N+ +A+ + ++
Sbjct: 1782 TGD-NWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1840
Query: 565 SEVKEELAGQKD-ELQLSDLLKQGYN 589
E KEE + + EL++ L Q ++
Sbjct: 1841 KEAKEEAELEAELELEMKTLSPQPHS 1866
Score = 40.8 bits (94), Expect = 0.005
Identities = 48/246 (19%), Positives = 102/246 (41%), Gaps = 55/246 (22%)
Query: 356 EVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E +L+L ++ Y+ + +NI D V++++S+ + V +
Sbjct: 776 EISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI---------VGQQ 826
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 827 GGGL------------------------SVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV------------ENFSTFIKCIFTQFRIILG 522
++ F ++ + F ++ LG LFG + +NF + + I T F+I+
Sbjct: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQ 922
Query: 523 DFDYNAI----DNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYS----EVKEELAGQ 574
+ D+N + + YF+ + F +VL N+ +AI+ + + +E+ +GQ
Sbjct: 923 E-DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQ 981
Query: 575 KDELQL 580
+QL
Sbjct: 982 LSCIQL 987
Score = 33.9 bits (76), Expect = 0.62
Identities = 53/259 (20%), Positives = 91/259 (35%), Gaps = 86/259 (33%)
Query: 381 YLSSIWNILDLVVILLSIVAV--------GFHIFRTLEVNRLMGKLLQQPNTYADFEFLA 432
YL S WN+LD +++L+S++ + G I L V RL+ L
Sbjct: 1341 YLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTL-------------- 1386
Query: 433 FWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA 492
+ + IS + + + TL K I V+ F +
Sbjct: 1387 -------------------RPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1427
Query: 493 QLGYLLF--------GTQVENFSTFIKCIFTQFRII--------LG-------------- 522
LG LF G N + C +R + LG
Sbjct: 1428 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1487
Query: 523 --DFDYNAIDNANRILGPA---------YFVTYVFFVFFVLLNMFLAIINDTYSEVK--- 568
D Y+ +D P YF++++ V F +LNMF+ ++ + + + +
Sbjct: 1488 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1547
Query: 569 -EELAGQKDELQLSDLLKQ 586
EE A +++E +L L K+
Sbjct: 1548 EEEEARRREEKRLRRLEKK 1566
>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
isoform 4 [Homo sapiens]
Length = 2332
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 58/266 (21%)
Query: 355 CEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNR 413
C IF V +V+E + +L R + WN LDL ++LLSI+ + TLE
Sbjct: 1646 CNYIFTVI---FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI------TLEEIE 1696
Query: 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
+ L P L ++ K + M L T+ +
Sbjct: 1697 VNASLPINPTIIRIMRVLRI-----------------ARVLKLLKMAVGMRALLDTVMQA 1739
Query: 474 AKDILGFAVMFFIVFFAYAQLGYLLFGT-------------QVENFSTFIKCIFTQFRII 520
+ ++F ++FF +A LG LFG + F F T FR+
Sbjct: 1740 LPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1799
Query: 521 LGDFDYNAIDNA------------NRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
GD ++N I N ++ P YFV++V FVL+N+ +A+ + ++
Sbjct: 1800 TGD-NWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1858
Query: 565 SEVKEELAGQKD-ELQLSDLLKQGYN 589
E KEE + + EL++ L Q ++
Sbjct: 1859 KEAKEEAELEAELELEMKTLSPQPHS 1884
Score = 40.8 bits (94), Expect = 0.005
Identities = 48/246 (19%), Positives = 102/246 (41%), Gaps = 55/246 (22%)
Query: 356 EVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E +L+L ++ Y+ + +NI D V++++S+ + V +
Sbjct: 776 EISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI---------VGQQ 826
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 827 GGGL------------------------SVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV------------ENFSTFIKCIFTQFRIILG 522
++ F ++ + F ++ LG LFG + +NF + + I T F+I+
Sbjct: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQ 922
Query: 523 DFDYNAI----DNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYS----EVKEELAGQ 574
+ D+N + + YF+ + F +VL N+ +AI+ + + +E+ +GQ
Sbjct: 923 E-DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQ 981
Query: 575 KDELQL 580
+QL
Sbjct: 982 LSCIQL 987
Score = 35.0 bits (79), Expect = 0.28
Identities = 55/265 (20%), Positives = 93/265 (35%), Gaps = 86/265 (32%)
Query: 381 YLSSIWNILDLVVILLSIVAV--------GFHIFRTLEVNRLMGKLLQQPNTYADFEFLA 432
YL S WN+LD +++L+S++ + G I L V RL+ L
Sbjct: 1341 YLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTL-------------- 1386
Query: 433 FWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA 492
+ + IS + + + TL K I V+ F +
Sbjct: 1387 -------------------RPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1427
Query: 493 QLGYLLF--------GTQVENFSTFIKCIFTQFRII--------LG-------------- 522
LG LF G N + C +R + LG
Sbjct: 1428 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1487
Query: 523 --DFDYNAIDNANRILGPA---------YFVTYVFFVFFVLLNMFLAIINDTYSEVK--- 568
D Y+ +D P YF++++ V F +LNMF+ ++ + + + +
Sbjct: 1488 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1547
Query: 569 -EELAGQKDELQLSDLLKQGYNKTL 592
EE A +++E +L L K+ N L
Sbjct: 1548 EEEEARRREEKRLRRLEKKRRNLML 1572
>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
isoform 8 [Homo sapiens]
Length = 2284
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 58/266 (21%)
Query: 355 CEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNR 413
C IF V +V+E + +L R + WN LDL ++LLSI+ + TLE
Sbjct: 1646 CNYIFTVI---FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI------TLEEIE 1696
Query: 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
+ L P L ++ K + M L T+ +
Sbjct: 1697 VNASLPINPTIIRIMRVLRI-----------------ARVLKLLKMAVGMRALLDTVMQA 1739
Query: 474 AKDILGFAVMFFIVFFAYAQLGYLLFGT-------------QVENFSTFIKCIFTQFRII 520
+ ++F ++FF +A LG LFG + F F T FR+
Sbjct: 1740 LPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1799
Query: 521 LGDFDYNAIDNA------------NRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
GD ++N I N ++ P YFV++V FVL+N+ +A+ + ++
Sbjct: 1800 TGD-NWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1858
Query: 565 SEVKEELAGQKD-ELQLSDLLKQGYN 589
E KEE + + EL++ L Q ++
Sbjct: 1859 KEAKEEAELEAELELEMKTLSPQPHS 1884
Score = 40.8 bits (94), Expect = 0.005
Identities = 48/246 (19%), Positives = 102/246 (41%), Gaps = 55/246 (22%)
Query: 356 EVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E +L+L ++ Y+ + +NI D V++++S+ + V +
Sbjct: 776 EISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI---------VGQQ 826
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 827 GGGL------------------------SVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV------------ENFSTFIKCIFTQFRIILG 522
++ F ++ + F ++ LG LFG + +NF + + I T F+I+
Sbjct: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQ 922
Query: 523 DFDYNAI----DNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYS----EVKEELAGQ 574
+ D+N + + YF+ + F +VL N+ +AI+ + + +E+ +GQ
Sbjct: 923 E-DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQ 981
Query: 575 KDELQL 580
+QL
Sbjct: 982 LSCIQL 987
Score = 35.0 bits (79), Expect = 0.28
Identities = 55/265 (20%), Positives = 93/265 (35%), Gaps = 86/265 (32%)
Query: 381 YLSSIWNILDLVVILLSIVAV--------GFHIFRTLEVNRLMGKLLQQPNTYADFEFLA 432
YL S WN+LD +++L+S++ + G I L V RL+ L
Sbjct: 1341 YLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTL-------------- 1386
Query: 433 FWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA 492
+ + IS + + + TL K I V+ F +
Sbjct: 1387 -------------------RPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1427
Query: 493 QLGYLLF--------GTQVENFSTFIKCIFTQFRII--------LG-------------- 522
LG LF G N + C +R + LG
Sbjct: 1428 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1487
Query: 523 --DFDYNAIDNANRILGPA---------YFVTYVFFVFFVLLNMFLAIINDTYSEVK--- 568
D Y+ +D P YF++++ V F +LNMF+ ++ + + + +
Sbjct: 1488 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1547
Query: 569 -EELAGQKDELQLSDLLKQGYNKTL 592
EE A +++E +L L K+ N L
Sbjct: 1548 EEEEARRREEKRLRRLEKKRRNLML 1572
>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
isoform 6 [Homo sapiens]
Length = 2306
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 58/266 (21%)
Query: 355 CEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNR 413
C IF V +V+E + +L R + WN LDL ++LLSI+ + TLE
Sbjct: 1623 CNYIFTVI---FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI------TLEEIE 1673
Query: 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
+ L P L ++ K + M L T+ +
Sbjct: 1674 VNASLPINPTIIRIMRVLRI-----------------ARVLKLLKMAVGMRALLDTVMQA 1716
Query: 474 AKDILGFAVMFFIVFFAYAQLGYLLFGT-------------QVENFSTFIKCIFTQFRII 520
+ ++F ++FF +A LG LFG + F F T FR+
Sbjct: 1717 LPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1776
Query: 521 LGDFDYNAIDNA------------NRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
GD ++N I N ++ P YFV++V FVL+N+ +A+ + ++
Sbjct: 1777 TGD-NWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1835
Query: 565 SEVKEELAGQKD-ELQLSDLLKQGYN 589
E KEE + + EL++ L Q ++
Sbjct: 1836 KEAKEEAELEAELELEMKTLSPQPHS 1861
Score = 37.7 bits (86), Expect = 0.043
Identities = 43/222 (19%), Positives = 91/222 (40%), Gaps = 51/222 (22%)
Query: 356 EVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E +L+L ++ Y+ + +NI D V++++S+ + V +
Sbjct: 776 EISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI---------VGQQ 826
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 827 GGGL------------------------SVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV------------ENFSTFIKCIFTQFRIILG 522
++ F ++ + F ++ LG LFG + +NF + + I T F+I+
Sbjct: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQ 922
Query: 523 DFDYNAI----DNANRILGPAYFVTYVFFVFFVLLNMFLAII 560
+ D+N + + YF+ + F +VL N+ +AI+
Sbjct: 923 E-DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAIL 963
Score = 35.0 bits (79), Expect = 0.28
Identities = 55/265 (20%), Positives = 93/265 (35%), Gaps = 86/265 (32%)
Query: 381 YLSSIWNILDLVVILLSIVAV--------GFHIFRTLEVNRLMGKLLQQPNTYADFEFLA 432
YL S WN+LD +++L+S++ + G I L V RL+ L
Sbjct: 1318 YLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTL-------------- 1363
Query: 433 FWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA 492
+ + IS + + + TL K I V+ F +
Sbjct: 1364 -------------------RPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 493 QLGYLLF--------GTQVENFSTFIKCIFTQFRII--------LG-------------- 522
LG LF G N + C +R + LG
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 523 --DFDYNAIDNANRILGPA---------YFVTYVFFVFFVLLNMFLAIINDTYSEVK--- 568
D Y+ +D P YF++++ V F +LNMF+ ++ + + + +
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1524
Query: 569 -EELAGQKDELQLSDLLKQGYNKTL 592
EE A +++E +L L K+ N L
Sbjct: 1525 EEEEARRREEKRLRRLEKKRRNLML 1549
>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
isoform 11 [Homo sapiens]
Length = 2261
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 58/266 (21%)
Query: 355 CEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNR 413
C IF V +V+E + +L R + WN LDL ++LLSI+ + TLE
Sbjct: 1623 CNYIFTVI---FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI------TLEEIE 1673
Query: 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
+ L P L ++ K + M L T+ +
Sbjct: 1674 VNASLPINPTIIRIMRVLRI-----------------ARVLKLLKMAVGMRALLDTVMQA 1716
Query: 474 AKDILGFAVMFFIVFFAYAQLGYLLFGT-------------QVENFSTFIKCIFTQFRII 520
+ ++F ++FF +A LG LFG + F F T FR+
Sbjct: 1717 LPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1776
Query: 521 LGDFDYNAIDNA------------NRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
GD ++N I N ++ P YFV++V FVL+N+ +A+ + ++
Sbjct: 1777 TGD-NWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1835
Query: 565 SEVKEELAGQKD-ELQLSDLLKQGYN 589
E KEE + + EL++ L Q ++
Sbjct: 1836 KEAKEEAELEAELELEMKTLSPQPHS 1861
Score = 37.7 bits (86), Expect = 0.043
Identities = 43/222 (19%), Positives = 91/222 (40%), Gaps = 51/222 (22%)
Query: 356 EVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E +L+L ++ Y+ + +NI D V++++S+ + V +
Sbjct: 776 EISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI---------VGQQ 826
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 827 GGGL------------------------SVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV------------ENFSTFIKCIFTQFRIILG 522
++ F ++ + F ++ LG LFG + +NF + + I T F+I+
Sbjct: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQ 922
Query: 523 DFDYNAI----DNANRILGPAYFVTYVFFVFFVLLNMFLAII 560
+ D+N + + YF+ + F +VL N+ +AI+
Sbjct: 923 E-DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAIL 963
Score = 35.0 bits (79), Expect = 0.28
Identities = 55/265 (20%), Positives = 93/265 (35%), Gaps = 86/265 (32%)
Query: 381 YLSSIWNILDLVVILLSIVAV--------GFHIFRTLEVNRLMGKLLQQPNTYADFEFLA 432
YL S WN+LD +++L+S++ + G I L V RL+ L
Sbjct: 1318 YLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTL-------------- 1363
Query: 433 FWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA 492
+ + IS + + + TL K I V+ F +
Sbjct: 1364 -------------------RPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 493 QLGYLLF--------GTQVENFSTFIKCIFTQFRII--------LG-------------- 522
LG LF G N + C +R + LG
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 523 --DFDYNAIDNANRILGPA---------YFVTYVFFVFFVLLNMFLAIINDTYSEVK--- 568
D Y+ +D P YF++++ V F +LNMF+ ++ + + + +
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1524
Query: 569 -EELAGQKDELQLSDLLKQGYNKTL 592
EE A +++E +L L K+ N L
Sbjct: 1525 EEEEARRREEKRLRRLEKKRRNLML 1549
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 58/266 (21%)
Query: 355 CEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNR 413
C IF V +V+E + +L R + WN LDL ++LLSI+ + TLE
Sbjct: 1635 CNYIFTVI---FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI------TLEEIE 1685
Query: 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
+ L P L ++ K + M L T+ +
Sbjct: 1686 VNASLPINPTIIRIMRVLRI-----------------ARVLKLLKMAVGMRALLDTVMQA 1728
Query: 474 AKDILGFAVMFFIVFFAYAQLGYLLFGT-------------QVENFSTFIKCIFTQFRII 520
+ ++F ++FF +A LG LFG + F F T FR+
Sbjct: 1729 LPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1788
Query: 521 LGDFDYNAIDNA------------NRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
GD ++N I N ++ P YFV++V FVL+N+ +A+ + ++
Sbjct: 1789 TGD-NWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1847
Query: 565 SEVKEELAGQKD-ELQLSDLLKQGYN 589
E KEE + + EL++ L Q ++
Sbjct: 1848 KEAKEEAELEAELELEMKTLSPQPHS 1873
Score = 40.8 bits (94), Expect = 0.005
Identities = 48/246 (19%), Positives = 102/246 (41%), Gaps = 55/246 (22%)
Query: 356 EVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E +L+L ++ Y+ + +NI D V++++S+ + V +
Sbjct: 776 EISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI---------VGQQ 826
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 827 GGGL------------------------SVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV------------ENFSTFIKCIFTQFRIILG 522
++ F ++ + F ++ LG LFG + +NF + + I T F+I+
Sbjct: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQ 922
Query: 523 DFDYNAI----DNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYS----EVKEELAGQ 574
+ D+N + + YF+ + F +VL N+ +AI+ + + +E+ +GQ
Sbjct: 923 E-DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQ 981
Query: 575 KDELQL 580
+QL
Sbjct: 982 LSCIQL 987
Score = 34.7 bits (78), Expect = 0.36
Identities = 54/263 (20%), Positives = 93/263 (35%), Gaps = 86/263 (32%)
Query: 381 YLSSIWNILDLVVILLSIVAV--------GFHIFRTLEVNRLMGKLLQQPNTYADFEFLA 432
YL S WN+LD +++L+S++ + G I L V RL+ L
Sbjct: 1341 YLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTL-------------- 1386
Query: 433 FWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA 492
+ + IS + + + TL K I V+ F +
Sbjct: 1387 -------------------RPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1427
Query: 493 QLGYLLF--------GTQVENFSTFIKCIFTQFRII--------LG-------------- 522
LG LF G N + C +R + LG
Sbjct: 1428 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1487
Query: 523 --DFDYNAIDNANRILGPA---------YFVTYVFFVFFVLLNMFLAIINDTYSEVK--- 568
D Y+ +D P YF++++ V F +LNMF+ ++ + + + +
Sbjct: 1488 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1547
Query: 569 -EELAGQKDELQLSDLLKQGYNK 590
EE A +++E +L L K+ +K
Sbjct: 1548 EEEEARRREEKRLRRLEKKRRSK 1570
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 58/266 (21%)
Query: 355 CEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNR 413
C IF V +V+E + +L R + WN LDL ++LLSI+ + TLE
Sbjct: 1612 CNYIFTVI---FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI------TLEEIE 1662
Query: 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
+ L P L ++ K + M L T+ +
Sbjct: 1663 VNASLPINPTIIRIMRVLRI-----------------ARVLKLLKMAVGMRALLDTVMQA 1705
Query: 474 AKDILGFAVMFFIVFFAYAQLGYLLFGT-------------QVENFSTFIKCIFTQFRII 520
+ ++F ++FF +A LG LFG + F F T FR+
Sbjct: 1706 LPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1765
Query: 521 LGDFDYNAIDNA------------NRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
GD ++N I N ++ P YFV++V FVL+N+ +A+ + ++
Sbjct: 1766 TGD-NWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1824
Query: 565 SEVKEELAGQKD-ELQLSDLLKQGYN 589
E KEE + + EL++ L Q ++
Sbjct: 1825 KEAKEEAELEAELELEMKTLSPQPHS 1850
Score = 37.7 bits (86), Expect = 0.043
Identities = 43/222 (19%), Positives = 91/222 (40%), Gaps = 51/222 (22%)
Query: 356 EVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E +L+L ++ Y+ + +NI D V++++S+ + V +
Sbjct: 776 EISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI---------VGQQ 826
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 827 GGGL------------------------SVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV------------ENFSTFIKCIFTQFRIILG 522
++ F ++ + F ++ LG LFG + +NF + + I T F+I+
Sbjct: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQ 922
Query: 523 DFDYNAI----DNANRILGPAYFVTYVFFVFFVLLNMFLAII 560
+ D+N + + YF+ + F +VL N+ +AI+
Sbjct: 923 E-DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAIL 963
Score = 34.7 bits (78), Expect = 0.36
Identities = 54/263 (20%), Positives = 93/263 (35%), Gaps = 86/263 (32%)
Query: 381 YLSSIWNILDLVVILLSIVAV--------GFHIFRTLEVNRLMGKLLQQPNTYADFEFLA 432
YL S WN+LD +++L+S++ + G I L V RL+ L
Sbjct: 1318 YLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTL-------------- 1363
Query: 433 FWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA 492
+ + IS + + + TL K I V+ F +
Sbjct: 1364 -------------------RPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 493 QLGYLLF--------GTQVENFSTFIKCIFTQFRII--------LG-------------- 522
LG LF G N + C +R + LG
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 523 --DFDYNAIDNANRILGPA---------YFVTYVFFVFFVLLNMFLAIINDTYSEVK--- 568
D Y+ +D P YF++++ V F +LNMF+ ++ + + + +
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1524
Query: 569 -EELAGQKDELQLSDLLKQGYNK 590
EE A +++E +L L K+ +K
Sbjct: 1525 EEEEARRREEKRLRRLEKKRRSK 1547
>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
isoform 9 [Homo sapiens]
Length = 2273
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 58/266 (21%)
Query: 355 CEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNR 413
C IF V +V+E + +L R + WN LDL ++LLSI+ + TLE
Sbjct: 1635 CNYIFTVI---FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI------TLEEIE 1685
Query: 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
+ L P L ++ K + M L T+ +
Sbjct: 1686 VNASLPINPTIIRIMRVLRI-----------------ARVLKLLKMAVGMRALLDTVMQA 1728
Query: 474 AKDILGFAVMFFIVFFAYAQLGYLLFGT-------------QVENFSTFIKCIFTQFRII 520
+ ++F ++FF +A LG LFG + F F T FR+
Sbjct: 1729 LPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1788
Query: 521 LGDFDYNAIDNA------------NRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
GD ++N I N ++ P YFV++V FVL+N+ +A+ + ++
Sbjct: 1789 TGD-NWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1847
Query: 565 SEVKEELAGQKD-ELQLSDLLKQGYN 589
E KEE + + EL++ L Q ++
Sbjct: 1848 KEAKEEAELEAELELEMKTLSPQPHS 1873
Score = 40.8 bits (94), Expect = 0.005
Identities = 48/246 (19%), Positives = 102/246 (41%), Gaps = 55/246 (22%)
Query: 356 EVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E +L+L ++ Y+ + +NI D V++++S+ + V +
Sbjct: 776 EISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI---------VGQQ 826
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 827 GGGL------------------------SVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV------------ENFSTFIKCIFTQFRIILG 522
++ F ++ + F ++ LG LFG + +NF + + I T F+I+
Sbjct: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQ 922
Query: 523 DFDYNAI----DNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYS----EVKEELAGQ 574
+ D+N + + YF+ + F +VL N+ +AI+ + + +E+ +GQ
Sbjct: 923 E-DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQ 981
Query: 575 KDELQL 580
+QL
Sbjct: 982 LSCIQL 987
Score = 34.7 bits (78), Expect = 0.36
Identities = 54/263 (20%), Positives = 93/263 (35%), Gaps = 86/263 (32%)
Query: 381 YLSSIWNILDLVVILLSIVAV--------GFHIFRTLEVNRLMGKLLQQPNTYADFEFLA 432
YL S WN+LD +++L+S++ + G I L V RL+ L
Sbjct: 1341 YLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTL-------------- 1386
Query: 433 FWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA 492
+ + IS + + + TL K I V+ F +
Sbjct: 1387 -------------------RPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1427
Query: 493 QLGYLLF--------GTQVENFSTFIKCIFTQFRII--------LG-------------- 522
LG LF G N + C +R + LG
Sbjct: 1428 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1487
Query: 523 --DFDYNAIDNANRILGPA---------YFVTYVFFVFFVLLNMFLAIINDTYSEVK--- 568
D Y+ +D P YF++++ V F +LNMF+ ++ + + + +
Sbjct: 1488 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1547
Query: 569 -EELAGQKDELQLSDLLKQGYNK 590
EE A +++E +L L K+ +K
Sbjct: 1548 EEEEARRREEKRLRRLEKKRRSK 1570
>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
isoform 2 [Homo sapiens]
Length = 2354
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 58/266 (21%)
Query: 355 CEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNR 413
C IF V +V+E + +L R + WN LDL ++LLSI+ + TLE
Sbjct: 1623 CNYIFTVI---FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI------TLEEIE 1673
Query: 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
+ L P L ++ K + M L T+ +
Sbjct: 1674 VNASLPINPTIIRIMRVLRI-----------------ARVLKLLKMAVGMRALLDTVMQA 1716
Query: 474 AKDILGFAVMFFIVFFAYAQLGYLLFGT-------------QVENFSTFIKCIFTQFRII 520
+ ++F ++FF +A LG LFG + F F T FR+
Sbjct: 1717 LPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1776
Query: 521 LGDFDYNAIDNA------------NRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
GD ++N I N ++ P YFV++V FVL+N+ +A+ + ++
Sbjct: 1777 TGD-NWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1835
Query: 565 SEVKEELAGQKD-ELQLSDLLKQGYN 589
E KEE + + EL++ L Q ++
Sbjct: 1836 KEAKEEAELEAELELEMKTLSPQPHS 1861
Score = 37.7 bits (86), Expect = 0.043
Identities = 43/222 (19%), Positives = 91/222 (40%), Gaps = 51/222 (22%)
Query: 356 EVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E +L+L ++ Y+ + +NI D V++++S+ + V +
Sbjct: 776 EISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI---------VGQQ 826
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 827 GGGL------------------------SVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV------------ENFSTFIKCIFTQFRIILG 522
++ F ++ + F ++ LG LFG + +NF + + I T F+I+
Sbjct: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQ 922
Query: 523 DFDYNAI----DNANRILGPAYFVTYVFFVFFVLLNMFLAII 560
+ D+N + + YF+ + F +VL N+ +AI+
Sbjct: 923 E-DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAIL 963
Score = 35.0 bits (79), Expect = 0.28
Identities = 55/265 (20%), Positives = 93/265 (35%), Gaps = 86/265 (32%)
Query: 381 YLSSIWNILDLVVILLSIVAV--------GFHIFRTLEVNRLMGKLLQQPNTYADFEFLA 432
YL S WN+LD +++L+S++ + G I L V RL+ L
Sbjct: 1318 YLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTL-------------- 1363
Query: 433 FWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA 492
+ + IS + + + TL K I V+ F +
Sbjct: 1364 -------------------RPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 493 QLGYLLF--------GTQVENFSTFIKCIFTQFRII--------LG-------------- 522
LG LF G N + C +R + LG
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 523 --DFDYNAIDNANRILGPA---------YFVTYVFFVFFVLLNMFLAIINDTYSEVK--- 568
D Y+ +D P YF++++ V F +LNMF+ ++ + + + +
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1524
Query: 569 -EELAGQKDELQLSDLLKQGYNKTL 592
EE A +++E +L L K+ N L
Sbjct: 1525 EEEEARRREEKRLRRLEKKRRNLML 1549
>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
isoform 14 [Homo sapiens]
Length = 2171
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 58/266 (21%)
Query: 355 CEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNR 413
C IF V +V+E + +L R + WN LDL ++LLSI+ + TLE
Sbjct: 1612 CNYIFTVI---FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI------TLEEIE 1662
Query: 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
+ L P L ++ K + M L T+ +
Sbjct: 1663 VNASLPINPTIIRIMRVLRI-----------------ARVLKLLKMAVGMRALLDTVMQA 1705
Query: 474 AKDILGFAVMFFIVFFAYAQLGYLLFGT-------------QVENFSTFIKCIFTQFRII 520
+ ++F ++FF +A LG LFG + F F T FR+
Sbjct: 1706 LPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVS 1765
Query: 521 LGDFDYNAIDNA------------NRILGPAYFVTYVFFVFFVLLNMFLAI----INDTY 564
GD ++N I N ++ P YFV++V FVL+N+ +A+ + ++
Sbjct: 1766 TGD-NWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1824
Query: 565 SEVKEELAGQKD-ELQLSDLLKQGYN 589
E KEE + + EL++ L Q ++
Sbjct: 1825 KEAKEEAELEAELELEMKTLSPQPHS 1850
Score = 37.7 bits (86), Expect = 0.043
Identities = 43/222 (19%), Positives = 91/222 (40%), Gaps = 51/222 (22%)
Query: 356 EVIFCVFIFYYVVEEILELHIHR-LRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414
E+ VF + +E +L+L ++ Y+ + +NI D V++++S+ + V +
Sbjct: 776 EISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI---------VGQQ 826
Query: 415 MGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA 474
G L +V F +++ K + F + + L +
Sbjct: 827 GGGL------------------------SVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
Query: 475 KDILGFAVMFFIVFFAYAQLGYLLFGTQV------------ENFSTFIKCIFTQFRIILG 522
++ F ++ + F ++ LG LFG + +NF + + I T F+I+
Sbjct: 863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQ 922
Query: 523 DFDYNAI----DNANRILGPAYFVTYVFFVFFVLLNMFLAII 560
+ D+N + + YF+ + F +VL N+ +AI+
Sbjct: 923 E-DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAIL 963
Score = 34.7 bits (78), Expect = 0.36
Identities = 54/263 (20%), Positives = 93/263 (35%), Gaps = 86/263 (32%)
Query: 381 YLSSIWNILDLVVILLSIVAV--------GFHIFRTLEVNRLMGKLLQQPNTYADFEFLA 432
YL S WN+LD +++L+S++ + G I L V RL+ L
Sbjct: 1318 YLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTL-------------- 1363
Query: 433 FWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA 492
+ + IS + + + TL K I V+ F +
Sbjct: 1364 -------------------RPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFG 1404
Query: 493 QLGYLLF--------GTQVENFSTFIKCIFTQFRII--------LG-------------- 522
LG LF G N + C +R + LG
Sbjct: 1405 ILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDG 1464
Query: 523 --DFDYNAIDNANRILGPA---------YFVTYVFFVFFVLLNMFLAIINDTYSEVK--- 568
D Y+ +D P YF++++ V F +LNMF+ ++ + + + +
Sbjct: 1465 WVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1524
Query: 569 -EELAGQKDELQLSDLLKQGYNK 590
EE A +++E +L L K+ +K
Sbjct: 1525 EEEEARRREEKRLRRLEKKRRSK 1547
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,272,264
Number of Sequences: 37866
Number of extensions: 1532141
Number of successful extensions: 6757
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 155
Number of HSP's that attempted gapping in prelim test: 5809
Number of HSP's gapped (non-prelim): 900
length of query: 805
length of database: 18,247,518
effective HSP length: 110
effective length of query: 695
effective length of database: 14,082,258
effective search space: 9787169310
effective search space used: 9787169310
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.