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Search of human proteins with 33188445
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33188445 microfilament and actin filament cross-linker
protein isoform a [Homo sapiens]
(5430 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33188445 microfilament and actin filament cross-linker protei... 1.061e+04 0.0
gi|33188443 microfilament and actin filament cross-linker protei... 7610 0.0
gi|221316622 dystonin isoform 3 [Homo sapiens] 5941 0.0
gi|221316618 dystonin isoform 2 [Homo sapiens] 5941 0.0
gi|221316624 dystonin isoform 4 [Homo sapiens] 5940 0.0
gi|34577047 dystonin isoform 1 [Homo sapiens] 5881 0.0
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 5303 0.0
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 1421 0.0
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 1382 0.0
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 1379 0.0
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 1379 0.0
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 1379 0.0
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 1378 0.0
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 1378 0.0
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 1378 0.0
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 1142 0.0
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens] 1111 0.0
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 1065 0.0
gi|58530840 desmoplakin isoform I [Homo sapiens] 557 e-157
gi|58530842 desmoplakin isoform II [Homo sapiens] 516 e-145
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 361 9e-99
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 361 1e-98
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 355 7e-97
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 354 1e-96
gi|5032281 dystrophin Dp427c isoform [Homo sapiens] 351 1e-95
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens] 351 1e-95
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens] 351 1e-95
gi|5032285 dystrophin Dp427l isoform [Homo sapiens] 351 1e-95
gi|5032283 dystrophin Dp427m isoform [Homo sapiens] 351 1e-95
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 345 7e-94
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 1.061e+04 bits (27543), Expect = 0.0
Identities = 5430/5430 (100%), Positives = 5430/5430 (100%)
Query: 1 MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDS 60
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDS
Sbjct: 1 MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDS 60
Query: 61 VLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLS 120
VLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLS
Sbjct: 61 VLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLS 120
Query: 121 GIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF 180
GIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF
Sbjct: 121 GIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF 180
Query: 181 QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDL 240
QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDL
Sbjct: 181 QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDL 240
Query: 241 VDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKV 300
VDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKV
Sbjct: 241 VDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKV 300
Query: 301 PEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK 360
PEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK
Sbjct: 301 PEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK 360
Query: 361 ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLR 420
ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLR
Sbjct: 361 ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLR 420
Query: 421 PAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQEC 480
PAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQEC
Sbjct: 421 PAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQEC 480
Query: 481 EGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP 540
EGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP
Sbjct: 481 EGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP 540
Query: 541 STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQ 600
STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQ
Sbjct: 541 STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQ 600
Query: 601 MKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGK 660
MKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGK
Sbjct: 601 MKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGK 660
Query: 661 LETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN 720
LETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN
Sbjct: 661 LETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN 720
Query: 721 YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQ 780
YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQ
Sbjct: 721 YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQ 780
Query: 781 HVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQ 840
HVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQ
Sbjct: 781 HVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQ 840
Query: 841 SKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR 900
SKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR
Sbjct: 841 SKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR 900
Query: 901 TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISW 960
TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISW
Sbjct: 901 TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISW 960
Query: 961 NYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEE 1020
NYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEE
Sbjct: 961 NYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEE 1020
Query: 1021 EVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD 1080
EVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD
Sbjct: 1021 EVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD 1080
Query: 1081 RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVE 1140
RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVE
Sbjct: 1081 RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVE 1140
Query: 1141 KMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTL 1200
KMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTL
Sbjct: 1141 KMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTL 1200
Query: 1201 RHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI 1260
RHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI
Sbjct: 1201 RHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI 1260
Query: 1261 AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQT 1320
AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQT
Sbjct: 1261 AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQT 1320
Query: 1321 ALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDA 1380
ALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDA
Sbjct: 1321 ALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDA 1380
Query: 1381 ITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST 1440
ITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST
Sbjct: 1381 ITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST 1440
Query: 1441 LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLS 1500
LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLS
Sbjct: 1441 LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLS 1500
Query: 1501 EKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLC 1560
EKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLC
Sbjct: 1501 EKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLC 1560
Query: 1561 SWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN 1620
SWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
Sbjct: 1561 SWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN 1620
Query: 1621 QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAE 1680
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAE
Sbjct: 1621 QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAE 1680
Query: 1681 NKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDK 1740
NKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDK
Sbjct: 1681 NKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDK 1740
Query: 1741 QCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL 1800
QCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL
Sbjct: 1741 QCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL 1800
Query: 1801 AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGS 1860
AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGS
Sbjct: 1801 AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGS 1860
Query: 1861 FSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKC 1920
FSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKC
Sbjct: 1861 FSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKC 1920
Query: 1921 TRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL 1980
TRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL
Sbjct: 1921 TRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL 1980
Query: 1981 QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLL 2040
QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLL
Sbjct: 1981 QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLL 2040
Query: 2041 QKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKS 2100
QKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKS
Sbjct: 2041 QKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKS 2100
Query: 2101 SLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE 2160
SLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE
Sbjct: 2101 SLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE 2160
Query: 2161 HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSS 2220
HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSS
Sbjct: 2161 HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSS 2220
Query: 2221 CGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETE 2280
CGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETE
Sbjct: 2221 CGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETE 2280
Query: 2281 GSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG 2340
GSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG
Sbjct: 2281 GSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG 2340
Query: 2341 KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRM 2400
KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRM
Sbjct: 2341 KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRM 2400
Query: 2401 EEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKV 2460
EEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKV
Sbjct: 2401 EEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKV 2460
Query: 2461 KEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAES 2520
KEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAES
Sbjct: 2461 KEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAES 2520
Query: 2521 QLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTG 2580
QLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTG
Sbjct: 2521 QLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTG 2580
Query: 2581 PGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAV 2640
PGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAV
Sbjct: 2581 PGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAV 2640
Query: 2641 GQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 2700
GQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE
Sbjct: 2641 GQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 2700
Query: 2701 LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPI 2760
LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPI
Sbjct: 2701 LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPI 2760
Query: 2761 SAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKN 2820
SAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKN
Sbjct: 2761 SAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKN 2820
Query: 2821 HWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL 2880
HWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL
Sbjct: 2821 HWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL 2880
Query: 2881 LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKT 2940
LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKT
Sbjct: 2881 LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKT 2940
Query: 2941 GSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQAL 3000
GSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQAL
Sbjct: 2941 GSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQAL 3000
Query: 3001 EPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIG 3060
EPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIG
Sbjct: 3001 EPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIG 3060
Query: 3061 QFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAE 3120
QFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAE
Sbjct: 3061 QFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAE 3120
Query: 3121 CRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND 3180
CRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND
Sbjct: 3121 CRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND 3180
Query: 3181 ATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK 3240
ATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK
Sbjct: 3181 ATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK 3240
Query: 3241 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3300
DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI
Sbjct: 3241 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3300
Query: 3301 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQL 3360
ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQL
Sbjct: 3301 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQL 3360
Query: 3361 ESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA 3420
ESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA
Sbjct: 3361 ESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA 3420
Query: 3421 KIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQ 3480
KIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQ
Sbjct: 3421 KIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQ 3480
Query: 3481 DRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA 3540
DRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA
Sbjct: 3481 DRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA 3540
Query: 3541 LNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE 3600
LNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE
Sbjct: 3541 LNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE 3600
Query: 3601 QARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLV 3660
QARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLV
Sbjct: 3601 QARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLV 3660
Query: 3661 LDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQ 3720
LDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQ
Sbjct: 3661 LDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQ 3720
Query: 3721 AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 3780
AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI
Sbjct: 3721 AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 3780
Query: 3781 FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE 3840
FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE
Sbjct: 3781 FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE 3840
Query: 3841 TRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMV 3900
TRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMV
Sbjct: 3841 TRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMV 3900
Query: 3901 EEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPP 3960
EEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPP
Sbjct: 3901 EEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPP 3960
Query: 3961 LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKL 4020
LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKL
Sbjct: 3961 LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKL 4020
Query: 4021 DQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPS 4080
DQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPS
Sbjct: 4021 DQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPS 4080
Query: 4081 IIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN 4140
IIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN
Sbjct: 4081 IIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN 4140
Query: 4141 KTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKE 4200
KTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKE
Sbjct: 4141 KTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKE 4200
Query: 4201 FKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKL 4260
FKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKL
Sbjct: 4201 FKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKL 4260
Query: 4261 EGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQA 4320
EGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQA
Sbjct: 4261 EGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQA 4320
Query: 4321 TVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFH 4380
TVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFH
Sbjct: 4321 TVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFH 4380
Query: 4381 SEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRL 4440
SEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRL
Sbjct: 4381 SEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRL 4440
Query: 4441 MLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWL 4500
MLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWL
Sbjct: 4441 MLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWL 4500
Query: 4501 TLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDV 4560
TLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDV
Sbjct: 4501 TLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDV 4560
Query: 4561 VLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSEL 4620
VLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSEL
Sbjct: 4561 VLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSEL 4620
Query: 4621 EISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEV 4680
EISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEV
Sbjct: 4621 EISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEV 4680
Query: 4681 RDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVM 4740
RDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVM
Sbjct: 4681 RDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVM 4740
Query: 4741 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 4800
NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV
Sbjct: 4741 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 4800
Query: 4801 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKK 4860
SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKK
Sbjct: 4801 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKK 4860
Query: 4861 VEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALS 4920
VEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALS
Sbjct: 4861 VEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALS 4920
Query: 4921 ELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVD 4980
ELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVD
Sbjct: 4921 ELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVD 4980
Query: 4981 RVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQ 5040
RVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQ
Sbjct: 4981 RVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQ 5040
Query: 5041 VWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQD 5100
VWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQD
Sbjct: 5041 VWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQD 5100
Query: 5101 GKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKDAYRPTTD 5160
GKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKDAYRPTTD
Sbjct: 5101 GKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKDAYRPTTD 5160
Query: 5161 ADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGGGWMAL 5220
ADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGGGWMAL
Sbjct: 5161 ADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGGGWMAL 5220
Query: 5221 DEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSA 5280
DEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSA
Sbjct: 5221 DEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSA 5280
Query: 5281 SQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGA 5340
SQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGA
Sbjct: 5281 SQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGA 5340
Query: 5341 KTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGN 5400
KTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGN
Sbjct: 5341 KTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGN 5400
Query: 5401 SRRGLNKPSKIPTMSKKTTTASPRTPGPKR 5430
SRRGLNKPSKIPTMSKKTTTASPRTPGPKR
Sbjct: 5401 SRRGLNKPSKIPTMSKKTTTASPRTPGPKR 5430
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 7610 bits (19745), Expect = 0.0
Identities = 3916/4025 (97%), Positives = 3950/4025 (98%), Gaps = 11/4025 (0%)
Query: 1415 EEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEEL 1474
E+ KV+ + Q ++++L WV K ++SE + + + + + L + +
Sbjct: 1916 EKTKVLNQHTQLE-GRLQDLRAWVGNKNLILNSKGSNSEI-DVDSLNLCLQQYEDLKQPM 1973
Query: 1475 TTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQS 1534
+K Q+ Q F+++H LS ++ +Q+ LN L +++ D+ + +A Q+ LQ
Sbjct: 1974 AERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQG 2033
Query: 1535 QLAHQTEQ---KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSD 1591
L ++ KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSD
Sbjct: 2034 HLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSD 2093
Query: 1592 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETR 1651
LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETR
Sbjct: 2094 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETR 2153
Query: 1652 VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ 1711
VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ
Sbjct: 2154 VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ 2213
Query: 1712 LSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLD 1771
LSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLD
Sbjct: 2214 LSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLD 2273
Query: 1772 QHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWL 1831
QHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWL
Sbjct: 2274 QHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWL 2333
Query: 1832 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 1891
ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE
Sbjct: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393
Query: 1892 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 1951
GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC
Sbjct: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 2453
Query: 1952 EANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPD 2011
EANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPD
Sbjct: 2454 EANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPD 2513
Query: 2012 HRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGK 2071
HRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGK
Sbjct: 2514 HRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGK 2573
Query: 2072 QVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEV 2131
QVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEV
Sbjct: 2574 QVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEV 2633
Query: 2132 SQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFF 2191
SQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFF
Sbjct: 2634 SQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFF 2693
Query: 2192 QQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKER 2251
QQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKER
Sbjct: 2694 QQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKER 2753
Query: 2252 EKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWAS 2311
EKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWAS
Sbjct: 2754 EKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWAS 2813
Query: 2312 KGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCD 2371
KGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCD
Sbjct: 2814 KGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCD 2873
Query: 2372 MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2431
MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT
Sbjct: 2874 MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2933
Query: 2432 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRW 2491
KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRW
Sbjct: 2934 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRW 2993
Query: 2492 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 2551
ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ
Sbjct: 2994 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 3053
Query: 2552 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNS 2611
QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNS
Sbjct: 3054 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNS 3113
Query: 2612 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 2671
RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL
Sbjct: 3114 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 3173
Query: 2672 EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALA 2731
EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALA
Sbjct: 3174 EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALA 3233
Query: 2732 STQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVI 2791
STQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVI
Sbjct: 3234 STQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVI 3293
Query: 2792 VAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVE 2851
VAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVE
Sbjct: 3294 VAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVE 3353
Query: 2852 DLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSS 2911
DLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSS
Sbjct: 3354 DLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSS 3413
Query: 2912 EADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL 2971
EADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL
Sbjct: 3414 EADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL 3473
Query: 2972 EIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQA 3031
EIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQA
Sbjct: 3474 EIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQA 3533
Query: 3032 EVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTD 3091
EVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTD
Sbjct: 3534 EVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTD 3593
Query: 3092 SLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLT 3151
SLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLT
Sbjct: 3594 SLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLT 3653
Query: 3152 ERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKM 3211
ERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKM
Sbjct: 3654 ERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKM 3713
Query: 3212 FQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQ 3271
FQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQ
Sbjct: 3714 FQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQ 3773
Query: 3272 LQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRK 3331
LQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRK
Sbjct: 3774 LQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRK 3833
Query: 3332 ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF 3391
ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF
Sbjct: 3834 ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF 3893
Query: 3392 HETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3451
HETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ
Sbjct: 3894 HETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3953
Query: 3452 SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL 3511
SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL
Sbjct: 3954 SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL 4013
Query: 3512 AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 3571
AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV
Sbjct: 4014 AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 4073
Query: 3572 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 3631
LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG
Sbjct: 4074 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 4133
Query: 3632 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 3691
GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN
Sbjct: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 4193
Query: 3692 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA 3751
EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA
Sbjct: 4194 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA 4253
Query: 3752 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 3811
QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS
Sbjct: 4254 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 4313
Query: 3812 ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES 3871
ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES
Sbjct: 4314 ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES 4373
Query: 3872 IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQ 3931
IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQ
Sbjct: 4374 IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQ 4433
Query: 3932 STQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFE 3991
STQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFE
Sbjct: 4434 STQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFE 4493
Query: 3992 ALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKF 4051
ALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKF
Sbjct: 4494 ALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKF 4553
Query: 4052 WYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGA 4111
WYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGA
Sbjct: 4554 WYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGA 4613
Query: 4112 DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL 4171
DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL
Sbjct: 4614 DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL 4673
Query: 4172 DNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD 4231
DNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD
Sbjct: 4674 DNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD 4733
Query: 4232 RDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQ 4291
RDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQ
Sbjct: 4734 RDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQ 4793
Query: 4292 RPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAM 4351
RPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAM
Sbjct: 4794 RPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAM 4853
Query: 4352 NQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAR 4411
NQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAR
Sbjct: 4854 NQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAR 4913
Query: 4412 EQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSK 4471
EQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSK
Sbjct: 4914 EQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSK 4973
Query: 4472 MEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA 4531
MEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA
Sbjct: 4974 MEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA 5033
Query: 4532 NEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 4591
NEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA
Sbjct: 5034 NEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 5093
Query: 4592 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYD 4651
RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYD
Sbjct: 5094 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYD 5153
Query: 4652 TTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDA 4711
TTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDA
Sbjct: 5154 TTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDA 5213
Query: 4712 LQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELI 4771
LQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELI
Sbjct: 5214 LQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELI 5273
Query: 4772 ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAE 4831
ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAE
Sbjct: 5274 ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAE 5333
Query: 4832 QTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIK 4891
QTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIK
Sbjct: 5334 QTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIK 5393
Query: 4892 HWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPI 4951
HWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPI
Sbjct: 5394 HWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPI 5453
Query: 4952 PQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLS 5011
PQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLS
Sbjct: 5454 PQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLS 5513
Query: 5012 QPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFD 5071
QPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFD
Sbjct: 5514 QPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFD 5573
Query: 5072 VWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIF 5131
VWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIF
Sbjct: 5574 VWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIF 5633
Query: 5132 DRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKY 5191
DRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKY
Sbjct: 5634 DRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKY 5693
Query: 5192 R------FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFI 5245
R FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFI
Sbjct: 5694 RFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFI 5753
Query: 5246 LPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIP 5305
LPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIP
Sbjct: 5754 LPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIP 5813
Query: 5306 SSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSR 5365
SSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSR
Sbjct: 5814 SSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSR 5873
Query: 5366 ASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGLNKPSKIPTMSKKTTTASPRT 5425
ASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGLNKPSKIPTMSKKTTTASPRT
Sbjct: 5874 ASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGLNKPSKIPTMSKKTTTASPRT 5933
Query: 5426 PGPKR 5430
PGPKR
Sbjct: 5934 PGPKR 5938
Score = 717 bits (1850), Expect = 0.0
Identities = 767/3786 (20%), Positives = 1606/3786 (42%), Gaps = 273/3786 (7%)
Query: 1217 LDEEIAKAKVVAEQMSRLTPERNLDLERYQEKG-SQLQERWHRVIAQLEIRQSELESIQE 1275
L + + +AKV+ ++ LT + +LE + SQ QE +++ LE L+
Sbjct: 1837 LQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLS 1896
Query: 1276 VLGDY---RACHGTLIKWIEETTA-QQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQT 1331
+ D R H IE+T Q G+ +D R ++ L ++ ++
Sbjct: 1897 SVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVG--NKNLILNSKGSNSEI 1954
Query: 1332 KLDQCQKFSQQYSTIVKDY-----ELQLMTY--KAFVE--SQQKSPGKRRRMLSSSDAIT 1382
+D QQY + + +L + + + F+ +Q SP + R+ML + +
Sbjct: 1955 DVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQ 2014
Query: 1383 QEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHV--EKVKELLGWVST 1440
+ F D+ + A V H L+++E+E V +KQ++ +++++L WV
Sbjct: 2015 RSFQDILEQTAAQVDALQGH-------LQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQ 2067
Query: 1441 LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLS 1500
R G + ++ + ++K + + L +++ + + +K + F+ ++ KLS
Sbjct: 2068 AERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLS 2127
Query: 1501 EKEKKQISEQLNALNKAYHDLCDGSANQLQQLQ----SQLAHQTEQKTLQKQQNTCHQQL 1556
+E + E+L+ + Y L + + ++L+ S L +TE+ K+ +++
Sbjct: 2128 PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKI 2187
Query: 1557 EDLCSWV-------GQAERALAGHQGRT-----------------TQQDLSALQKNQSDL 1592
+ L WV GQ L G + + Q L K +
Sbjct: 2188 DALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMM 2247
Query: 1593 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRV 1652
K ++ ++ +F + + F++++ L+P E L++KL + KEQY T +
Sbjct: 2248 KARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQY-----STSL 2302
Query: 1653 AQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQL 1712
AQ E E LQ E +K ++ K+ ++ W
Sbjct: 2303 AQSEAELKQVQTLQDELQK------FLQDHKEFES---W--------------------- 2332
Query: 1713 SGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ 1772
LE+ + + + G +PE L + + ++++S + + T S Q LD
Sbjct: 2333 ----LERSEKELENMHKG-GSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDM 2387
Query: 1773 HG---HNLTPEE-QQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFE 1828
P E +++ KL + E+Y+ ++ + L + +F +
Sbjct: 2388 ENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQ 2447
Query: 1829 SWLERSEKELENMHKG--GSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 1886
+W++ E +E + S P L L E++ H+ + + + ++++E
Sbjct: 2448 AWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIE 2507
Query: 1887 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 1946
EP+ V++ + +L S L + Q Q S +SL
Sbjct: 2508 G------EPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQ 2561
Query: 1947 WMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEG 2006
+ E N+E +++S GV+QE LAT +L++++A + +E +++ ME
Sbjct: 2562 SIGEVEQNLEGKQVSSLSS--GVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETAD 2619
Query: 2007 EPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQ 2066
+Q + F+ L E+ S L+K + Q++ + E L LQ E +
Sbjct: 2620 STTA--AVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAE-MFEHLSGKLQQFMENKS 2676
Query: 2067 NL--EGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2124
+ G Q + Q+ N++++ Q+ +L+ +VT +
Sbjct: 2677 RMLASGNQPDQDITHFFQQIQELNLEMED----QQENLDTLEHLVTELSSCGFALDLCQH 2732
Query: 2125 QGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPD 2184
Q ++ + + F +L +E+E Q + F L Q++++ + +
Sbjct: 2733 QDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPP-TETS 2791
Query: 2185 QDITHFFQQIQELNLEMED--------QQENL--DTLEHLVTE-------------LSSC 2221
+QI+ L ++D ++ N +LE+L+ E L S
Sbjct: 2792 MSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSV 2851
Query: 2222 GFAL----------DLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRT 2271
G ++ DL + Q + ++ + +L + ER++ + +++E K +
Sbjct: 2852 GSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANS 2911
Query: 2272 FQKWLKETEGSIPPTETSMSAKELE---KQIEHLKSLLDDWASKGTLVEEINCKGTSLEN 2328
+WL+ E + + S + E Q E K+ L + ++++ +L
Sbjct: 2912 VLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVK---EALAG 2968
Query: 2329 LIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHE 2388
L+ +T P+SQ ++ +IQ ++N ++E+ V
Sbjct: 2969 LL--VTYPNSQ---------------------EAENWKKIQ---EELNSRWERATEVTVA 3002
Query: 2389 RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2448
RQ L+ + + + + WL KE ++ + +S + AQ + + L
Sbjct: 3003 RQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLS--IDPNMLNAQKQQVQFMLK 3060
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPN--SQEAENWKKIQEELNSRWERATEVTVARQRQLE 2506
E E + +++ EA G+L T P S +K + +N +W T+ +R Q++
Sbjct: 3061 EFEARRQQHEQLNEAAQGIL-TGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQID 3119
Query: 2507 ESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ 2566
++ +Q +L L EK +G LS+ + ++ Q + V+ L+E R
Sbjct: 3120 QAIVKSTQYQ----ELLQDLSEKVRAVG--QRLSVQ-SAISTQPEAVKQQLEETSEIRSD 3172
Query: 2567 HEQLNEAAQGILTGPGDVSL------STSQVQKELQSINQKWVELTDKLNSRSSQIDQAI 2620
EQL+ + T ++S+ +++K L+++ L D R +++ A+
Sbjct: 3173 LEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAAL 3232
Query: 2621 VKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQL--DHEV 2678
+ Q+Q++ +L + + + IS + E ++ QL+E E + L Q +EV
Sbjct: 3233 ASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEV 3292
Query: 2679 KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 2738
A+ LSV GE+ K L+ +L + + L ADR +RL+ + Q++Q
Sbjct: 3293 IVAEGESLLLSVPPGEE--KRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 3350
Query: 2739 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 2798
++L W++D +++ ++ ++ +L+S L ++ + + E++ + + L
Sbjct: 3351 HVEDLVPWIEDCKAKMSE-LRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADIL 3409
Query: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858
+ S E+ ++++ + + + ++++ + L++ Q+ +++Q +++ +E
Sbjct: 3410 INSSEADED--GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVE 3467
Query: 2859 DCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSE------ 2912
K + L+ S S L ++ ++ +L+ L D L N ++
Sbjct: 3468 GAKHQ-------LEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDA 3520
Query: 2913 ---ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKH 2969
+D + + Q V + + + +E + + +F + + ++
Sbjct: 3521 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580
Query: 2970 QLEIFDALGSQACS-NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGS-DASQL 3027
+L+ A+G S +E +R + L+ ++ + ++E+ +G+ D L
Sbjct: 3581 ELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE--EGTLDLLGL 3638
Query: 3028 LHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIG 3087
+ E ++ ++ +R + +E L + F+ +++ + ++ +G
Sbjct: 3639 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3698
Query: 3088 RDTDSLQSQIEDVRLF-LNKIHVLKLDIEASEAECRHMLEEEG-TLDLLGLKRELEALNK 3145
+ + + Q+ D ++F ++ L++ ++ + +++ G D+ GL+ ++E +N
Sbjct: 3699 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3758
Query: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
+ L ++ R QL+ L F L+ L EE A Q E +++ Q
Sbjct: 3759 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQ 3818
Query: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265
+ + K+ Q+ +D + + + G + QSA + D + + +E + +RW L K
Sbjct: 3819 IQEQKLLQR-LLDDRKATVDMLQAEGGRIAQSA-ELADREKITGQLESLESRWTELLSKA 3876
Query: 3266 AQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQR 3325
A R QL++ L+ +F + EP+ +L+ TE+ +AN +P + ++ QI K L+
Sbjct: 3877 AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEE 3936
Query: 3326 LLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDIL 3385
+++ V G ++ A++ ++ +++SL++R++E+ + + L+ L
Sbjct: 3937 DIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQAL 3996
Query: 3386 VLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3445
A+ F E + ++L+ E KL++ + + +Q H AL E+I N +V Q
Sbjct: 3997 SNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQ 4056
Query: 3446 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 3505
A+K GQ+L T+ E ++ EK+D ++ RY++I + L+QA A F
Sbjct: 4057 AIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 4116
Query: 3506 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQ 3565
E+ WL EVE++L++ + + + + L +E++ + +D + +ALL+
Sbjct: 4117 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLEL 4176
Query: 3566 TTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEE 3625
+ + + +Y ++ T + + ++ A Q + +++ + W+ E +
Sbjct: 4177 VPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKR 4236
Query: 3626 ELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDK 3685
+L G +Q Q QK +++ H+ +D + + + L +
Sbjct: 4237 KLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQE 4296
Query: 3686 LVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLE 3745
+QY+ +S +R ++ A Q+ + + W+ ET+ + L ++
Sbjct: 4297 KTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAID 4356
Query: 3746 QDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEA 3805
+Q Q + + I HK +D+L ++ E+ +++EK + Y
Sbjct: 4357 HEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL-KELNPEEGEMVEEKYQKAENMYAQ 4415
Query: 3806 ISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEM 3865
I +R L+ A Q E ++++ P +E L ++L P + E+
Sbjct: 4416 IKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPL-------IPAEV 4468
Query: 3866 RQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM---------------VEEKYQKAENM 3910
++RE I+++K +L K+ P + L E+ +++K +
Sbjct: 4469 DKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFF 4528
Query: 3911 YAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 3970
+ IK +R + + + + + + ++ +++ L P + P+ I+
Sbjct: 4529 WEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPS---IIK 4585
Query: 3971 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4030
+ + ++ E + L E ++ G +LI +K E++ +D+M WE++
Sbjct: 4586 QQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEK----PEVRKSIDEMNNAWENL 4641
Query: 4031 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4090
+ER K D ++ A ++ + A+ + +T + + G D + +K Q+ +
Sbjct: 4642 NKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMK 4701
Query: 4091 TIKEETDGLHEELEFIRILGADLI-FACGETEKPEVRKSIDEMNNAWENLNKTWKERLEK 4149
K E E+E + G ++ A ET++ +R+ + E+ + WENL + R K
Sbjct: 4702 EFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHK 4761
Query: 4150 LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQ 4209
LE A+ A Q+Q L+ + WL +T L P+ D ++ +L + K +V Q
Sbjct: 4762 LEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQ 4821
Query: 4210 IEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQ 4269
+E +N G +L+ + + D +R L + WE++ +K R+ +L+ L
Sbjct: 4822 ATVETVNKAGNELLESSAGD-DASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQG 4880
Query: 4270 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATV-ETVNKA 4328
F +E+ + LT E L A +P G P+ +L H L + + A + T + ++K
Sbjct: 4881 FHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKG 4940
Query: 4329 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLL 4388
LL S + + Q W V K EER+ +L+ L A F + +++F+
Sbjct: 4941 RLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFIN 5000
Query: 4389 ELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKG-RLMLLSRDD 4447
LT E L+ + P + T Q++ H +++ A + +L G +L LS+
Sbjct: 5001 WLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQ 5060
Query: 4448 SGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSL 4507
K + ++ +W V + ER L++A A +F + ++ I+WL AE L
Sbjct: 5061 DVVLIK--NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL 5118
Query: 4508 NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS-QKQDVVLIKNL 4566
+ S + + Q+ +HK F + + +TG LK + +D + N
Sbjct: 5119 DSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF 5178
Query: 4567 LVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDP 4626
L V+ +W+ V +S+ER L++A + QF +A + L+DWL E L + + D
Sbjct: 5179 LGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL 5238
Query: 4627 DKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDT 4686
D + + HK FQK LG + R+GR L E + +D+ + L E+ +WDT
Sbjct: 5239 DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENS--RDDTTWVKGQLQELSTRWDT 5296
Query: 4687 VCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAH 4746
VC SV +Q +LE+AL + F D + L++WL + E L + D + + +L+D H
Sbjct: 5297 VCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTH 5356
Query: 4747 KVFQKELGKRTGTVQVLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSR 4805
K F K++ ++ V G ++ D T +K + + R++ V + Q R
Sbjct: 5357 KEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQR 5416
Query: 4806 LEQALKQAEVFRDTVHMLLEWLSEAEQTL--RFRGALPDDTEALQSLIDTHKEFMKKVEE 4863
LE AL + + + LL W+ AE TL R + +P + + +++LI H+ FM+++
Sbjct: 5417 LETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTR 5476
Query: 4864 KRVDVN 4869
K+ DV+
Sbjct: 5477 KQPDVD 5482
Score = 459 bits (1180), Expect = e-128
Identities = 808/4322 (18%), Positives = 1702/4322 (39%), Gaps = 485/4322 (11%)
Query: 1031 HLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALR 1090
+L K+ + D E+TV + IS ++ + + +QS+ +R+ A+R
Sbjct: 881 NLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLERE----EAVR 936
Query: 1091 IAEQEHTQ----EDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVY 1146
+ ++ + +R +D ++F H L+ NL + ++ +
Sbjct: 937 LLTKQVVDGGIIHHISGMRLSVD------NAFRHGLIGEDLAEKLKRVENLNIHQIFNPE 990
Query: 1147 GLSTVYLNKLKTVDVIV----RSIQDAELLVKGYEIKLSQEEVVLAD-----LSALEAHW 1197
+ L K +D+I R IQ+ + + +S + + LA+ L EA
Sbjct: 991 TKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVL 1050
Query: 1198 ST-LRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERW 1256
S + H + D +N E + K K+ E + +R L++ + + + ++
Sbjct: 1051 SPGMMHGIVD--PENCRIVPYSELVKKCKIDIE-----SGQRYLEVIPFSDIKDGVSDKV 1103
Query: 1257 HRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQL 1316
+ +++ + + S +VL + +A G +I TA + + A + +++ E +
Sbjct: 1104 LTLSQAIQLGKVDFASTLKVL-EAQANTGGIID-----TATGKRLTLASALEEKLVDENM 1157
Query: 1317 SQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKA--FVESQQKSPGKRRRM 1374
+ A + + FS Q T+V+ E +L++ + ++ R
Sbjct: 1158 VRIIASHQVLNGGIVDI-----FSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQ 1212
Query: 1375 LSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKEL 1434
+ + I E L+ + L + + + ++EE E++ + E Q EKVK
Sbjct: 1213 IEKQEGI--EVCALQNEFLGKDMLIACN-QTAEMSCNKVEESERLFQVENQSAQEKVKVR 1269
Query: 1435 LGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLA- 1493
+ +D E+A +++ +E K ++ ++ F++
Sbjct: 1270 V----------------------SDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISI 1307
Query: 1494 KHGHKLSEKEKKQISEQLNALNKAYHDLCD---------GSANQLQQLQSQLAHQTEQKT 1544
+ H L K Q+S L Y + CD N + Q + + E +
Sbjct: 1308 INPHNLKGKSLGQVS-----LTHPYSE-CDFKLKEVARNNMGNDTNEEQEKAVTKIEIIS 1361
Query: 1545 LQKQQNTC---HQQLEDLCSWVGQAERALAGHQGR-----TTQQDLSALQKNQSDLKD-- 1594
KQ +C + E+ + + + G+ QQ ++A K++ + ++
Sbjct: 1362 HMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNARVKSKREKREVI 1421
Query: 1595 LQDDIQNRATSF--------ATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEAL 1646
+++ I+ +F T ++D ++ K PRE+T+
Sbjct: 1422 VEESIRTCKPAFLSEEKLYQETAIRD----EHDSHIKSQPREMTS--------------- 1462
Query: 1647 QEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGG----QL 1702
E+ + A E+ ++T ++ E S + K +DAL + + + G L
Sbjct: 1463 SEKGKEADTEMGFSITFKIE---ESSSQVVPQGISVKHLDALTLFSSKQANEGKVNNLSL 1519
Query: 1703 LTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR---HQELLSQQQNF 1759
L E LS + GA ++ + + PE L Q KA+ ++ ++F
Sbjct: 1520 CLTLKPEENLS-REIACGA--QSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSF 1576
Query: 1760 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ-DELQ 1818
T+ + D + T E + + E KE+ + E + L+ +E+
Sbjct: 1577 QGTTRQETNYQDSWVTSKTKETKHQISSS-NECKEK-----SYQEVSFDPARGLKLEEIT 1630
Query: 1819 KFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTIS 1878
D KE +LE S+++ + H+G S + L LK + + E ++
Sbjct: 1631 VSRPDSKEVR-YLEFSDRK-DLHHQGSKSDDKLCGTLKSEIATQE-------------LT 1675
Query: 1879 GQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQF- 1937
G+K L+M N G E I ++V + + L K + G GQ +
Sbjct: 1676 GEKFLEMANPNVAGLEAGSIEDIVTQRGSRVLGSF--LPEKLFK-GVSQKENTGQQNAII 1732
Query: 1938 ----QNSADSLQAWMQACEA-NVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVE 1992
+++ + C A EK + + PG Q T + + + P
Sbjct: 1733 SPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFR 1792
Query: 1993 KLQKV-ARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQS-- 2049
Q V R + E + + + Q L +LAE LL +A +
Sbjct: 1793 ATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELK 1852
Query: 2050 -----VQESLESLLQSIGEVEQNLEGKQVSSLSSGV--IQEALAT-----NMKL------ 2091
V + LE + Q I Q + + + +L +Q++L++ N +L
Sbjct: 1853 DLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNA 1912
Query: 2092 ----KQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQ----- 2142
K + Q + LE + + ++ + +G +E+ LCLQQ
Sbjct: 1913 VEIEKTKVLNQHTQLEGRLQDLRAWV--GNKNLILNSKGSNSEIDVDSLNLCLQQYEDLK 1970
Query: 2143 ---QEKESSLKKLLPQAEMF--EHLSGKLQQFMENKSRMLASGNQPDQDIT--------- 2188
E+++ L L + F EH Q R+L + QDI
Sbjct: 1971 QPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDA 2030
Query: 2189 ---HFFQQIQELNLEMEDQQENL--DTLEHLVTELSSCGFAL------------------ 2225
H Q QE ++ +Q+N LE L + + AL
Sbjct: 2031 LQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKN 2090
Query: 2226 --DLCQHQDRVQNLRKDFTELQKTVKE-----------------REKDASSCQEQLDEFR 2266
DL QD +QN F + K ++ REK +EQ + +
Sbjct: 2091 QSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREK-LHQAKEQYEALQ 2149
Query: 2267 KLVRTFQKWLKE--TEGSIPPTETSMSAKELEKQIEHLKSLLDDW-----ASKGTLVEEI 2319
+ R QK L+E T TE S +AKEL + + + +LL DW +S G L+ +
Sbjct: 2150 EETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALL-DWVTSVGSSGGQLLTNL 2208
Query: 2320 ----NCKGTSLENLIMEIT--------APDSQGKTGSILPSVGSS-VGSVNGYHTCKDLT 2366
G SLE ++ T AP+ K ++ + + +
Sbjct: 2209 PGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSA 2268
Query: 2367 EIQCDMSDVNLKYE-------KLGGVLHERQESL---QAILNRMEEVHKEANSVLQ---- 2412
+ D NL E KLG + + SL +A L +++ + E LQ
Sbjct: 2269 QAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE 2328
Query: 2413 ---WLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLV 2469
WLE E+ L++M S ET+ + + +F ++ + ++ V + +L
Sbjct: 2329 FESWLERSEKELENMHKGGS--SPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLD 2386
Query: 2470 TYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLAC-------FQAAESQL 2522
+ +E + +I + + + ATE A + SHL FQ + L
Sbjct: 2387 MENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSL 2446
Query: 2523 RPWLMEKELMMGVL--GPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTG 2580
+ W+ E + L ++ DP +L Q + + +E + E+L + A+ I+
Sbjct: 2447 QAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI 2506
Query: 2581 PGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAV 2640
G+ + VQ+ SI + L+ L RSS + +AI +S QE L+ L + + V
Sbjct: 2507 EGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEV 2566
Query: 2641 GQRLSVQSAISTQPEAVKQQLEETSEIRSD-------LEQLDHEVKEAQTLCDELSVLIG 2693
Q L + S +++ L +++ D LE V D + +
Sbjct: 2567 EQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2626
Query: 2694 EQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ 2753
+ L E+ +R E + L Q ++ + L+ L + F+ + +L+ ++++K
Sbjct: 2627 QGKLA-EVSQRFEQLCLQQQ-------EKESSLKKLLPQAEMFEHLSGKLQQFMENKSRM 2678
Query: 2754 QAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQN 2813
A + Q+QE + ++ + E +V E S ++ + + +QN
Sbjct: 2679 LASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2738
Query: 2814 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP 2873
L+ + EL K +R+ C ++ +++ V W+++ + + ++
Sbjct: 2739 ----LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSA 2794
Query: 2874 VQLESSLLRSKAMLNEVEKRRSLLEILN----SAADILINSSEADEDG------------ 2917
+LE + K++L++ + +L+E +N S ++++ + D G
Sbjct: 2795 KELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSS 2854
Query: 2918 ---------------IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEK 2962
I+ + + +N + + L + SL+ + R+ E + ++ +
Sbjct: 2855 VGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQ 2914
Query: 2963 KVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALE---PQVDYLRNFTQGLVEDAP 3019
+E + L+ DA+ S + + + + L LE P++ ++ GL+ P
Sbjct: 2915 WLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYP 2974
Query: 3020 DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLE----GIGQFHCRVREMFSQLAD 3075
+ +A + Q+E +R V + +LE + F ++ L +
Sbjct: 2975 NSQEAENW----KKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME 3030
Query: 3076 LDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEG--TLDL 3133
+ + +G + D + L +Q + V+ L + + E + +L G +L
Sbjct: 3031 KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLST 3090
Query: 3134 LGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQW 3193
+++EL+++N++ +LT++ +R Q++ + + + L+ L++ A + ++Q
Sbjct: 3091 SQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQS 3150
Query: 3194 VVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEE 3253
+ T+ E + QQL + + + ++ L ++++ L L G+ L+ +E
Sbjct: 3151 AISTQPEAVKQQLEETSEIRSD-LEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 3209
Query: 3254 INARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVV 3313
+ L A RI +LQ AL +FQ + L +WL D + A P SA+ + +
Sbjct: 3210 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 3269
Query: 3314 KAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREK-ITGQLESLESRWTELLS 3372
++Q+QE + Q+ L+ + +++ AEG + S + ++ + QL L++ W EL
Sbjct: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 3329
Query: 3373 KAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKAL 3432
K A RQ +L+D + A+++ E + ++ + K++ V +++ ++R KA+
Sbjct: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELR-VTLDPVQLESSLLRSKAM 3388
Query: 3433 EEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQ 3492
++E + + L + + E G+ EK + + + K L++
Sbjct: 3389 LNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKA-GINQNMDAVTEELQAKTGSLEE 3447
Query: 3493 ALSNARLFGED------EVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIV 3546
R F E +VE E+ D L S + + L Q AL E V
Sbjct: 3448 MTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQAL-EPQV 3506
Query: 3547 NRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLA 3606
+ +N Q + + G + + + + + + ++ + +E +
Sbjct: 3507 DYLRNFTQGL-----VEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI 3561
Query: 3607 TKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELK---KEVMEHRLVLDT 3663
+F E+ L ++++EL G G Q + ++++ ++ +L ++
Sbjct: 3562 GQFHCRVREMFSQLADLDDEL---DGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEA 3618
Query: 3664 VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQ--- 3720
R +LE GL + + N+Q +++ R ++++ + R + + +
Sbjct: 3619 SEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLK 3678
Query: 3721 --------AADAE-LAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMD 3771
A +AE L WV T+ +++ +Q A ++ + +D ++ K +
Sbjct: 3679 GLNDATTAAEEAEALQWVVGTEVEII---------NQQLADFKMFQKEQVDPLQMK--LQ 3727
Query: 3772 ELFSHRSEIFGTCGEE-QKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWET 3830
++ + + G++ L+ E + ++ ++ ++R A+L+ A + +F +
Sbjct: 3728 QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDA 3787
Query: 3831 YEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL- 3889
E L W+ +T LIA P+ +++ ++ Q +E + L+ + + K +D L G ++
Sbjct: 3788 LEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIA 3847
Query: 3890 KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 3949
+ + E + + + E+ + ++ + R L++ + + Q FH+ EP+ + L
Sbjct: 3848 QSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQ---FHETAEPISDFL 3904
Query: 3950 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4009
+L + + KI++ I +K+ ++E + G+ L + A++
Sbjct: 3905 SVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQ 3964
Query: 4010 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4069
+ + +K+D + + +I+ R + L A F D +L + + +D +
Sbjct: 3965 GV----LSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL 4020
Query: 4070 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4129
+ ++ +Q + EE + ++ G L+ E +++ +
Sbjct: 4021 SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL 4080
Query: 4130 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN 4189
D + + ++ T + L LE A Q A ++Q T + + WL +L T
Sbjct: 4081 DGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGE 4140
Query: 4190 TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENL 4249
+ KE K EV + ++ ++ +N +L+ R+ + + +++ ++ +
Sbjct: 4141 QIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRA-REGLDKLVSDANEQYKLV 4199
Query: 4250 GEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHH 4309
+ I R +++ A+ Q++ A + ++W+ T+ L A PI + +L
Sbjct: 4200 SDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK 4259
Query: 4310 VLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQL 4369
D++ H+ +++ + +E+ + + + L+ + E++ Q +E++ ER +L
Sbjct: 4260 AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARL 4319
Query: 4370 ---QSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKA 4426
Q + Q + E+ ++ E + +QL + P EQL E QL+
Sbjct: 4320 ERAQVLVNQFWETYEELSPWIEETRALIAQLPS-------PAIDHEQLRQQQEEMRQLRE 4372
Query: 4427 KEETYNQLLDKGRLM--LLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALN 4484
+ +DK + L + G E+ E + + ++ +R L+EA++
Sbjct: 4373 SIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVS 4432
Query: 4485 LA---TEFQNSLQEFINWLTLAEQSLNIASPPSL--ILNTVLSQIEEHKVFANEVNAHRD 4539
+ TEF + ++ + TL S + PP + ++ + I ++K E+ +
Sbjct: 4433 QSTQITEFHDKIEPMLE--TLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQP 4490
Query: 4540 QIIELDQTGNQLKFLSQKQDVVL----IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 4595
L + G +L SQ D L I++ L + WE + R+ ER D + A
Sbjct: 4491 SFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELA 4550
Query: 4596 KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 4655
++F L+ ++D + + DP IK Q+ + ++ G +
Sbjct: 4551 EKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRI 4610
Query: 4656 TGRAL---KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDAL 4712
G L +T PE + +D E+ + W+ + ER KLE+A+ + Q+ D L
Sbjct: 4611 LGADLIFACGETEKPEVRKSID----EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTL 4666
Query: 4713 QALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIE 4772
QA+ DWL +L PV DL+ V + ++ K F+ E+ ++ ++ L G +++
Sbjct: 4667 QAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK 4726
Query: 4773 NSRDDT--TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEA 4830
+ D+T ++ L EL W+ + + +Q +LE AL F+ + L+ WL+
Sbjct: 4727 KATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHT 4786
Query: 4831 EQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTI 4890
E+ L + + D + ++ + H V + V + G +L D +++
Sbjct: 4787 EELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSL 4846
Query: 4891 KHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEP 4950
+ + + +E VL ++ +Q+L++ L + +E+ L + E+ L +P
Sbjct: 4847 RSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQL--SASKP 4904
Query: 4951 IPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSL 5010
+ + + H ++ K+ +TY + ++ + + SG
Sbjct: 4905 TGGLPETAREQLDTHMELYSQLKAKE-------ETYNQL-LDKGRLMLLSRDDSGSGSKT 4956
Query: 5011 SQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----LKEFA 5066
Q + L +W V ER+ KL +AL+ E L+EF
Sbjct: 4957 EQ-----------------SVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFI 4999
Query: 5067 NF 5068
N+
Sbjct: 5000 NW 5001
Score = 408 bits (1049), Expect = e-113
Identities = 680/3536 (19%), Positives = 1405/3536 (39%), Gaps = 339/3536 (9%)
Query: 591 ELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKE--------ARLY 642
+L SWV + ERA G+ + + L Q + +++L ++ +
Sbjct: 2060 DLCSWVGQA----ERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDI 2115
Query: 643 EGKMSQNFH-------TSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIW 695
EG M +N T+ E L + + QY L+E + + L+ V+ A +
Sbjct: 2116 EGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEA---VTSALQQ--- 2169
Query: 696 LNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAEL--LSLENHPA 753
E E+ + A + ++N I A ++ + + + +L +L SLE A
Sbjct: 2170 --ETEKSKAAKELAENKKKIDALLDWVTSVG---SSGGQLLTNLPGMEQLSGASLEKG-A 2223
Query: 754 KQTVEAYSAAVQS------QLQWMK---QLCLCVEQHVKENTAYFQFFSDAR------EL 798
T + Y Q+ Q + MK Q L +Q+ T Q F D E
Sbjct: 2224 LDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEE 2283
Query: 799 ESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQ- 857
+ L+ +K +YS S + L+ + Q DE ++ +Q S + RS+ ++
Sbjct: 2284 QQMLQQKLGELKEQYSTSLAQSEAELKQV-QTLQDELQKFLQDHKEFESWLERSEKELEN 2342
Query: 858 -----LKPRSPDHVLKNTISVKA-VCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGN 911
P + +LK S V ++ + + + VL+ + + K S GN
Sbjct: 2343 MHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGN 2402
Query: 912 EAMVPSVCFLIPPPNKDAIEM-------ASRVEQSYQKVMALWHQLHVNTKSLISWNYLR 964
L+ KDA E +R+ ++ +HQ + SL +W
Sbjct: 2403 ---------LVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 2453
Query: 965 KDLDLVQTWNLEKLRS----SAPGECH-------QIMKNLQAHY---EDFLQDSRDSVLF 1010
+ N+EKL S S PG Q+ + L H E + +RD +
Sbjct: 2454 EA-------NVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI 2506
Query: 1011 S---VADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRV 1067
D ++E ++ + FQ L S+ + ++ + I++ ++++ LE Q +
Sbjct: 2507 EGEPAPDHRHVQETTDSILSHFQSLSYSLA---ERSSLLQKAIAQSQSVQESLESLLQSI 2563
Query: 1068 VKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSS 1127
+ Q+L + + +A ++D+ + +S L+A F+ ++ S++
Sbjct: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFM-ETADSTT 2622
Query: 1128 VPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVL 1187
L+ +L + ++ + L K ++ ++ + E L + + + +L
Sbjct: 2623 AAVLQGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRML 2679
Query: 1188 ADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQE 1247
A + + + H+ +++ N E + + + ++S LDL ++Q+
Sbjct: 2680 ASGNQPD---QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFA--LDLCQHQD 2734
Query: 1248 KGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAE 1307
+ L++ + + ++ R+ + S QE L ++R T KW++ET + + +
Sbjct: 2735 RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKET--EGSIPPTETSM 2792
Query: 1308 DSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYK--AFVESQQ 1365
++ L +Q+ +L + T +++ ++ + K + + S
Sbjct: 2793 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVG 2852
Query: 1366 KSPGKRRRMLSSSD--AITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEE 1423
S G + D I + D+ +Y L + + + + L R+EE K
Sbjct: 2853 SSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSV 2912
Query: 1424 KQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSE 1483
Q +E +E+L + ++ T+ + K + KA L + E+ + K ++V E
Sbjct: 2913 LQ-WLESKEEVLKSMDAMSSPTK----TETVKAQAESNKAFLAE---LEQNSPKIQKVKE 2964
Query: 1484 AIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQK 1543
A+ L + + + K+I E+LN+ + ++ QL++ S LA
Sbjct: 2965 ALAG---LLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLA------ 3015
Query: 1544 TLQKQQNTCHQQLE-DLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNR 1602
C Q E L W+ + E + + ++ QK Q ++ + + + R
Sbjct: 3016 --------CFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQ--VQFMLKEFEAR 3065
Query: 1603 ATSFATVVKDIEGFME-ENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAV 1661
+ + +G + LS + ++++L +++ L ++ ++++A+
Sbjct: 3066 RQQHEQLNEAAQGILTGPGDVSLSTSQ---VQKELQSINQKWVELTDKLNSRSSQIDQAI 3122
Query: 1662 TSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGA 1721
KS +EL ++ L + V +VG ++LS S
Sbjct: 3123 V--------KSTQYQELLQD------LSEKVRAVG-------------QRLSVQS----- 3150
Query: 1722 LDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEE 1781
++ PE + +Q E E+ S + + AQ D+ +
Sbjct: 3151 --------AISTQPEAVKQQLE----ETSEIRSDLEQLDHEVKEAQTLCDELSVLI---G 3195
Query: 1782 QQMLQQKLGELKEQYSTSLAQSE----AELKQVQTLQDELQKFLQDHKEFESWLERSEKE 1837
+Q L+ +L + E + L E + ++Q Q+F Q E +WL+ + +
Sbjct: 3196 EQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ 3255
Query: 1838 LENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSE 1897
+ E L S L+ F + + H G + G+ +L P E
Sbjct: 3256 QAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-------LSVPPGE 3308
Query: 1898 IGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEK 1957
++++L + + L K S L + + ++Q + L W++ C+A + +
Sbjct: 3309 EKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE 3368
Query: 1958 LLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQE 2017
L V DP L+ L +K + E+ + + +E L A DI+ E D +++
Sbjct: 3369 L---RVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAA-DILINSSE--ADEDGIRD 3422
Query: 2018 TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLE-----GKQ 2072
I + +++ L ++ L++ + + QES +++ + + + LE G Q
Sbjct: 3423 EKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQ 3482
Query: 2073 VSSLSSGVIQEALATNMKLKQDIARQKSSL-EATREMVTRFMETADST----TAAVLQGK 2127
S + E L ++ Q + Q L T+ +V + +D++ A V Q +
Sbjct: 3483 ACSNKN---LEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQE 3539
Query: 2128 LAEVSQRFEQLCLQQQEKESSLKKLLPQA-EMFEHLSGKLQQFMENKSRMLASGNQPD-- 2184
EV QR C+ + K + + + EMF L+ + M A G D
Sbjct: 3540 FLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLA----DLDDELDGMGAIGRDTDSL 3595
Query: 2185 ----QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2240
+D+ F +I L L++E + H++ E + LDL + ++ L K
Sbjct: 3596 QSQIEDVRLFLNKIHVLKLDIEASEAE---CRHMLEEEGT----LDLLGLKRELEALNKQ 3648
Query: 2241 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2300
+L + K R QEQL+ V F + LK G T + A+ L+
Sbjct: 3649 CGKLTERGKAR-------QEQLELTLGRVEDFYRKLK---GLNDATTAAEEAEALQ---- 3694
Query: 2301 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2360
W GT VE IN + + E P Q K + G G +
Sbjct: 3695 --------WV-VGTEVEIINQQLADFKMFQKEQVDP-LQMKLQQV---NGLGQGLIQSAG 3741
Query: 2361 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2420
D+ ++ DM ++N ++ L + +R LQ L + +L WL EE+
Sbjct: 3742 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEEL 3801
Query: 2421 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENW 2480
+ + S+ K VKAQ + K L+ + + +A G + + E
Sbjct: 3802 IANQKPPSAEYK--VVKAQIQEQKLLQRLLDDRKATVDML-QAEGGRIAQSAELADREKI 3858
Query: 2481 KKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLS 2540
E L SRW ARQ+QLE+ F + +L E + P+
Sbjct: 3859 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3918
Query: 2541 IDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGI--LTGPGDVSLSTSQVQKELQSI 2598
+ Q + + + ++ E Q + Q + LT P + + + +++ S+
Sbjct: 3919 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGV----LSEKIDSL 3974
Query: 2599 NQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVK 2658
++ E+ D+ +++ +DQA+ + + E ++ + V +LS + + +
Sbjct: 3975 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLH 4034
Query: 2659 QQ----LEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQG 2714
+Q L EI + + +D +K Q L L GE+ L ++++L+ +
Sbjct: 4035 RQHADHLALNEEIVNRKKNVDQAIKNGQAL---LKQTTGEEVLL--IQEKLDGIKTRYAD 4089
Query: 2715 LEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQEN 2774
+ ++ + L+ A +FQ ++EL WL + + + A + S E++ Q
Sbjct: 4090 ITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQ 4149
Query: 2775 EEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQS 2834
+E +K + +H + V E LL + P + L + + ++ +S R
Sbjct: 4150 KELKKEVMEHRLVLDT-VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVD 4208
Query: 2835 RLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSEL-RVTLDPVQLESSLLRSKAM-LNEVEK 2892
+ +Q++Q+Y+ + + W+ + K K+ L + L+ Q + L KA ++ +
Sbjct: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRH 4268
Query: 2893 RRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLRE 2952
+ S+ E+ + ++I E + ++++ + Q +A++ + LE + +
Sbjct: 4269 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 4328
Query: 2953 FQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL----EKLRAQQEVLQALEPQVDYLR 3008
F E+++ + +E + + L S A ++ L E++R +E + +P +D L
Sbjct: 4329 FWETYEELSPWIEETR---ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLL 4385
Query: 3009 NFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLE---GIGQFHCR 3065
L E P+ + + +Q A+ + ++K+ V + ++ + I +FH +
Sbjct: 4386 KIGPQLKELNPEEGEMVEEKYQK--AENMYAQIKEEVRQRALALDEAVSQSTQITEFHDK 4443
Query: 3066 VREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHML 3125
+ M L +L L I + D ++ I D + ++ L+ EA + ++
Sbjct: 4444 IEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELI 4503
Query: 3126 EEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLEL----TLGRVEDFYRKLKGLNDA 3181
D +E++ Q E KAR E+ E+ L E F+ + L
Sbjct: 4504 GRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT 4563
Query: 3182 TTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKD 3241
++ G + II QQ+ + KE+ D L +L+ + LG LI + G +
Sbjct: 4564 IKDTQDIVHDLESPGIDPSIIKQQVEAAETI-KEETDGLHEELEFIRILGADLIFACG-E 4621
Query: 3242 CDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIA 3301
+ + ++E+N W LNK +R+ +L++A+ ++QD L+ + WL +T +
Sbjct: 4622 TEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC 4681
Query: 3302 NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSA-ELADREKITGQL 3360
P + VK Q+ E K + + ++ ++ L +G + + A + DR+ I L
Sbjct: 4682 TMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPL 4741
Query: 3361 ESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA 3420
L+ W L K A RQ +LE L+ QF E + +L+ TE+ L P+
Sbjct: 4742 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4801
Query: 3421 KIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQ 3480
I+ ++ +H L+ D+ H V K G L ++ + L +++++ + +
Sbjct: 4802 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4861
Query: 3481 DRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA 3540
+ + L L A+ F + + L L +E +LS+ + Q H+
Sbjct: 4862 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4921
Query: 3541 LNEEIVNRKKNVDQAIKNGQALL--------KQTTGEEVLLIQEKLDGIKTRYADITVTS 3592
L ++ +++ +Q + G+ +L T + V L+++K + ++ +
Sbjct: 4922 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEE---RK 4978
Query: 3593 SKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKK 3652
SK LE+A LAT+FQ++ +E WL E+ L + S + + K
Sbjct: 4979 SK----LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 5034
Query: 3653 EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI 3712
EV HR + +++ L L + + L+ +++ V +R +D A
Sbjct: 5035 EVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDAR 5094
Query: 3713 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 3772
+R++Q+ +A + W+ + + L + I + D+ QL K F + + D
Sbjct: 5095 KRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDT 5154
Query: 3773 LFSHRSEIFGTCGEEQKTVLQEKTESL-------IQQYEAISLLNSERYARLERAQVLVN 3825
+ ++KT+L E ++ L +++ + + ER +LE A +
Sbjct: 5155 TIRTGRAL------KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSG 5208
Query: 3826 QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKI 3885
QF + + L W+ + +A+ D + + + + ++ + + + L +
Sbjct: 5209 QFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRS 5268
Query: 3886 GPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 3945
G +L E + ++ V+ + Q+ + + + + L++A+ Q+ F D + +
Sbjct: 5269 GRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQA---EVFRDTVHML 5325
Query: 3946 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELI 4001
LE L LR +P + + ++ I +K ++E+ + + GE ++
Sbjct: 5326 LEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVIL 5381
Score = 128 bits (321), Expect = 2e-28
Identities = 310/1644 (18%), Positives = 629/1644 (38%), Gaps = 268/1644 (16%)
Query: 984 GECHQIMKNLQAHYED-----FLQDSRDSVLFSV-ADRLRLEEEVEACKARFQHLMKSME 1037
GE + N A ED F++D + VL AD L L EE+ K +K+ +
Sbjct: 4003 GEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQ 4062
Query: 1038 NEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHT 1097
K+ T ++ + + +++ + + D ALR EQ
Sbjct: 4063 ALLKQTTGEEVLL----------------IQEKLDGIKTRYADITVTSSKALRTLEQARQ 4106
Query: 1098 -----QEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRS-ELNLLVEKMDHVYGLSTV 1151
Q ++L L V + + QSP+ +P + + L E M+H L TV
Sbjct: 4107 LATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV 4166
Query: 1152 YLNKLKTVDVIV-RSIQDAELLVKG----YEI-------KLSQEEVVLADLSALEAHWST 1199
++++ R+ + + LV Y++ ++ + + + E
Sbjct: 4167 NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADA 4226
Query: 1200 LRHWLSDVKDKNSVFSV--LDEEIAKAKVVAEQMSRLTPERNLDL--ERY---------- 1245
W+++ K K L+++ A++ ++ + R+ D E +
Sbjct: 4227 ELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTC 4286
Query: 1246 -QEKGSQLQERWHRVIAQLEI-------RQSELESIQEVLGDYRACHGTLIKWIEETTA- 1296
+E+ + LQE+ +I Q E R + LE Q ++ + + L WIEET A
Sbjct: 4287 GEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRAL 4346
Query: 1297 -----------------QQEM-----------------------MKPGQAEDSRVLSEQL 1316
Q+EM +K E+ ++ E+
Sbjct: 4347 IAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKY 4406
Query: 1317 SQQTALFA----EIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSP---- 1368
+ ++A E+ + LD+ S Q + E L T + + P
Sbjct: 4407 QKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPA 4466
Query: 1369 --GKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHV------------KYISDALRRLE 1414
K R +S + + T E L+ + AL + + K I D L ++
Sbjct: 4467 EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMV 4526
Query: 1415 ---EEEKVVEEEKQEHVEKVKELLG--WVSTLARNTQGKATSS--ETKESTDIEKAILEQ 1467
E+ K EE++ V EL W A T K T ES I+ +I++Q
Sbjct: 4527 FFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQ 4586
Query: 1468 QV-LSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSA 1526
QV +E + + + + E ++ +I A E EK ++ + ++ +N A+ +L
Sbjct: 4587 QVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWK 4646
Query: 1527 NQLQQLQSQLAHQTE-QKTLQ--------------------KQQNTCHQQLEDLCS---- 1561
+L++L+ + + Q TLQ NT QL ++
Sbjct: 4647 ERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVE 4706
Query: 1562 -WVGQAERALAGHQGR------TTQQDLSALQKNQSDLKDLQDDIQNRAT---------- 1604
+ Q E HQG T + D +++ ++LK L +++ +
Sbjct: 4707 VYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGAL 4766
Query: 1605 ----SFATVVKDIEGFMEENQTKL--------SPRELTALREKLHQAKEQ---YEALQEE 1649
F ++++ ++ + L P+ + K H K ++A E
Sbjct: 4767 LALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVET 4826
Query: 1650 TRVAQKELEEAV----TSALQQETEK-----SKAAKELAENKKKIDALLDWVTSVGSSGG 1700
A EL E+ S+L+ E ++ E ++++ + L S
Sbjct: 4827 VNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE 4886
Query: 1701 QLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEM---MKAR---HQELLS 1754
L L ME AS G L T A E+LD E+ +KA+ + +LL
Sbjct: 4887 DFLLELTRMESQLSASKPTGGLPET--------AREQLDTHMELYSQLKAKEETYNQLLD 4938
Query: 1755 QQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ 1814
+ + +L+ D + T + +L+QK S+ + + +++L++ L
Sbjct: 4939 KGRLMLLSRD------DSGSGSKTEQSVALLEQKW----HVVSSKMEERKSKLEEALNLA 4988
Query: 1815 DELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRF 1874
E Q LQ EF +WL +E+ L T+ S ++ F+ +V +H+ +
Sbjct: 4989 TEFQNSLQ---EFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIE 5045
Query: 1875 VTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQY 1934
+ +G N K + ++ L+K+ L R+ + + G L+ +
Sbjct: 5046 LDQTG-------NQLKFLSQKQDV-VLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 5097
Query: 1935 HQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKL 1994
QF + L W++ E++++ L +++DP ++ QL+ K+ Q+ L Q +
Sbjct: 5098 KQFHEAWKKLIDWLEDAESHLDSELE--ISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTT 5155
Query: 1995 QKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESL 2054
+ R + E P D + + + + ++ ER L++A+ S ++L
Sbjct: 5156 IRTGRALKEKTLLP-EDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDAL 5214
Query: 2055 ESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFME 2114
++L+ + +VE L Q ++ + + ++++ ++ +++ + +E
Sbjct: 5215 QALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIE 5274
Query: 2115 TADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKS 2174
+ T V +G+L E+S R++ +C K+S L++ L QAE+F L +++
Sbjct: 5275 NSRDDTTWV-KGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAE 5333
Query: 2175 RMLA-SGNQPDQDITHFFQQIQELNLEM--EDQQENLDTLEHLVTELSSCGFALDLCQHQ 2231
+ L G PD T Q + + + E + +++ +D V + G + H
Sbjct: 5334 QTLRFRGALPDD--TEALQSLIDTHKEFMKKVEEKRVD-----VNSAVAMGEVILAVCHP 5386
Query: 2232 DRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMS 2291
D + ++ T ++ +E A Q++L+ + + L+E I ET++
Sbjct: 5387 DCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLI 5446
Query: 2292 AKELE---KQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPS 2348
++ E + I+ +K+L+ A T +EE+ K ++ + + + +
Sbjct: 5447 QRDQEPIPQNIDRVKALI---AEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEK 5503
Query: 2349 VGSSVGSVNGYHTCKDLTEIQCD------MSDVNLKYEKLGGVLHERQESLQAILNRMEE 2402
S T + + ++ ++ +++++ + ERQ L L+R+EE
Sbjct: 5504 SRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE 5563
Query: 2403 VHKEAN--------SVLQWLESKE 2418
+ + AN ++W+ K+
Sbjct: 5564 LKEFANFDFDVWRKKYMRWMNHKK 5587
Score = 39.7 bits (91), Expect = 0.082
Identities = 37/140 (26%), Positives = 63/140 (45%), Gaps = 29/140 (20%)
Query: 323 VDSLIPWIK--QHTILMSDKT-FPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYK 379
++ L+ WI+ + T++ D+ PQN +KAL ++ F E E+ K+ + R+ + YK
Sbjct: 5431 LEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME-EMTRKQPDVDRVTKTYK 5489
Query: 380 ----------LLEVWIEFGRIKLPQGYHP---------------NDVEEEWGKLIIEMLE 414
+E GR L Q P N + W ++ + LE
Sbjct: 5490 RKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALE 5549
Query: 415 REKSLRPAVERLELLLQIAN 434
R++ L A++RLE L + AN
Sbjct: 5550 RQRKLNDALDRLEELKEFAN 5569
Score = 38.9 bits (89), Expect = 0.14
Identities = 34/140 (24%), Positives = 59/140 (42%), Gaps = 12/140 (8%)
Query: 317 QEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEE 376
Q+YQ V+ L+PWI+ MS+ +PV+L E+ +L + +E+
Sbjct: 3346 QKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQL-----------ESSLLRSKAMLNEVEK 3394
Query: 377 LYKLLEVWIEFGRIKLPQGYHPND-VEEEWGKLIIEMLEREKSLRPAVERLELLLQIANK 435
LLE+ I + D + +E + M + L+ LE + Q +
Sbjct: 3395 RRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLRE 3454
Query: 436 IQNGALNCEEKLTLAKNTLQ 455
Q N E+K+ AK+ L+
Sbjct: 3455 FQESFKNIEKKVEGAKHQLE 3474
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 5941 bits (15413), Expect = 0.0
Identities = 3039/5549 (54%), Positives = 4065/5549 (73%), Gaps = 169/5549 (3%)
Query: 10 SERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQD-SVLDPAERA 68
S R S + S+ S++SGS SP P GDTLPWNLP HE+ KRK Q SVLDPAERA
Sbjct: 7 SYRCSMSSSADFSDEDDFSQKSGSASPAP-GDTLPWNLPKHERSKRKIQGGSVLDPAERA 65
Query: 69 VVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREK 128
V+R+ADERD+VQKKTFTKW+N+HLMKVRKH+NDLYEDLRDGHNLISLLEVLSG LPREK
Sbjct: 66 VLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREK 125
Query: 129 GRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYIS 188
GRMRFHRLQNVQIALD+LK+RQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI+++
Sbjct: 126 GRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVT 185
Query: 189 GESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQI 248
GES DMSAKE+LLLWTQ+ T GY GI+C NF++CW DGK+FNA+IH+YRPDL+DM V +
Sbjct: 186 GESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 245
Query: 249 QSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGIS 308
QSN NLE AF VAE++GV RLLD EDVDV SPDEKSVITYVSS+YDAFPKVPEGGEGI
Sbjct: 246 QSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIG 305
Query: 309 ATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKE 368
A +V+ +W EYQ+ V+ LI WI+ H MS++TFP NPVELKALYNQY+ FKETEI KE
Sbjct: 306 ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKE 365
Query: 369 REKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLEL 428
EK +I+ LYKLLE+WIEFGRIKL QGYHPND+E+EWGKLII MLEREK+LRP VERLE+
Sbjct: 366 TEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEM 425
Query: 429 LLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQ 488
L QIAN++Q ++ CE+KL LA N LQ+D+ LESG Q E+++ YI ECE L+RQ
Sbjct: 426 LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 485
Query: 489 VDLQILRDENYYQLEELAFRVMRLQDELVTLRLEC--------------TNLYRKGHFTS 534
+D+QIL D YYQ ++L RV +L+DE++ LR EC T L G S
Sbjct: 486 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQS 545
Query: 535 L-----ELVPPSTLT------TTHLKAEPLTKATHSSSTS-------------------- 563
L + + PS + T L + +T S TS
Sbjct: 546 LNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVP 605
Query: 564 -----------------WFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERA 606
RKP+ ++ L+ + +E+E N++FV +LL+WV+EMQ++L+R
Sbjct: 606 NFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRT 665
Query: 607 EWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYC 666
EWG+DLPSVE LE +++H ++EE SS+KEA++ E +M+ +YAE L +LE+QY
Sbjct: 666 EWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYA 725
Query: 667 KLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELT 726
KL TS + RHL +LH FVSRAT ELIWLNEKEEEE+AYDWS+ N+NI+ K++Y +EL
Sbjct: 726 KLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELM 785
Query: 727 MELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENT 786
EL++K++ +S+Q+ AE L LENHPA+ T+EAY AA+Q+Q W+ QLC CVEQH+KENT
Sbjct: 786 RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 845
Query: 787 AYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVA 846
AYF+FF+DA+E +LRNL+D+I+RKYSCD ++S+ +LEDL+Q+SM+EKE+L+Q KS++A
Sbjct: 846 AYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIA 905
Query: 847 SLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVI 906
+L+G++KTI+QLKPR+ D LK +I +KA+CDYRQIEITI K+DECVL +NS R KWKVI
Sbjct: 906 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVI 965
Query: 907 SPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKD 966
SPTGNEAMVPSVCF +PPPNK+A+++A+R+EQ YQ V+ LWH+ H+N KS++SW+YL +
Sbjct: 966 SPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINE 1025
Query: 967 LDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACK 1026
+D ++ N+ +++ PGE Q++ NLQ+ +EDFL+DS++S +FS +D +LE+EV CK
Sbjct: 1026 IDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK 1085
Query: 1027 ARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQD 1086
+Q L+KS E E++EE+V +YISE++NIRLRLE E R++++I++ +RD +
Sbjct: 1086 QYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT----PLERDDLHE 1141
Query: 1087 NALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVY 1146
+ RI EQE +++L++L+ DL ++ KC+ F Q+ +SSSVPTLRSELN++++ M+ VY
Sbjct: 1142 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1201
Query: 1147 GLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSD 1206
+S+ Y++KLKTV++++++ Q AE LVK YE KL +EE V+AD + +E STL+ W S+
Sbjct: 1202 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1261
Query: 1207 VKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIR 1266
V +K VF L++E+ KAK ++++M + ER+LD + ++EK QL ERW V Q++ R
Sbjct: 1262 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1321
Query: 1267 QSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEI 1326
+LE I + L YR + L WI++ Q ++ Q E+S+ L+ QL+QQ L +EI
Sbjct: 1322 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1381
Query: 1327 ERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFM 1386
E Q+K+D+CQK+++QYS VKDYELQ MTY+A V+SQQKSP KRRRM SS+D I QEFM
Sbjct: 1382 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441
Query: 1387 DLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQ 1446
DLRTRYTALVTL TQ++K+ D+L+RLEEEEK +EEEK+EHVEK KEL WVS +++ +
Sbjct: 1442 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1501
Query: 1447 GKATSSETKESTDIEKA----ILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEK 1502
D EKA +Q++ SEE++TKKEQ+SEA++T Q+FLAKHG K++++
Sbjct: 1502 ------------DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDE 1549
Query: 1503 EKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSW 1562
E+ ++ +Q+ L ++Y+ L S QLQ+ Q+ + E+K + ++Q ++L+ +C
Sbjct: 1550 ERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDL 1609
Query: 1563 VGQAERALAGHQGRTTQQDLSA-LQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQ 1621
+ Q E L GHQ D + L+K QS ++LQ D+Q A + A VVK+ E F++EN
Sbjct: 1610 LTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENG 1669
Query: 1622 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 1681
KLS + + +KL++AK + E L + ++KEL++ VT+A+++ETEK A K+L E+
Sbjct: 1670 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEES 1729
Query: 1682 KKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG---------------ALDT-T 1725
K KI+ LLDW+++V + T + + +G ++G L+T
Sbjct: 1730 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1789
Query: 1726 DGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQML 1785
DG +G Q E L++Q + +KA+H++++SQ Q I+ATQSAQ L++ G L+PEE++ L
Sbjct: 1790 DGQVGTTQ--ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1847
Query: 1786 QQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGG 1845
Q+ + ELK Y T+LA+SE ++K +LQ+EL+KF D+ EFE WL++SE+ELEN+ G
Sbjct: 1848 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 1907
Query: 1846 SSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE---GK-EPSEIGNL 1901
L + LKRQ SFSEDVISHKGDLR++TISG +VL+ S + GK + S
Sbjct: 1908 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHRE 1967
Query: 1902 VKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSD 1961
V+ KL AT+R+ +L+SKC LG++L L+ +Y +++++ L A +QACEA K LS+
Sbjct: 1968 VQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSE 2027
Query: 1962 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS 2021
+A DP LQ QL TK LQ +++ QV VEKL+K A +++ G P +Q+T D
Sbjct: 2028 PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDD 2087
Query: 2022 ILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVI 2081
I+ ++ LS S+ ER+ LQ + +S SVQ+ L+ +L +G VE +L+ + L+S +
Sbjct: 2088 IVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTAL 2147
Query: 2082 QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQ 2141
Q+ ++ N+ L+QDIA ++SS+ A E V +FMET D +TA+ LQ K+ ++S RF + +
Sbjct: 2148 QDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2207
Query: 2142 QQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEM 2201
+E + +++L + E+FE+LS KLQ F+E K++ L + P +D+T Q +QE E
Sbjct: 2208 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEF 2267
Query: 2202 EDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQ 2261
+ +++L+ L L+ E+SS G D ++ NL K F E++ T+KE+++ +SCQEQ
Sbjct: 2268 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQ 2327
Query: 2262 LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINC 2321
LD F+ LV++ + W+KET +P + S A++L K +E K L + W+ K ++++N
Sbjct: 2328 LDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2387
Query: 2322 KGTSLENLIMEITAPD---SQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK 2378
G SL NLI +T P + K+G + + + + + K LT I+ DM+D++
Sbjct: 2388 SGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHG 2447
Query: 2379 YEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA 2438
YE LG +L ++ L L+++++ +E+++++QWL+ + +PT TE VK
Sbjct: 2448 YEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKT 2507
Query: 2439 QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVT 2498
Q E NK+F AEL+QN K+Q++K+ L LL P++ EA WK++ E++S+W+ ++T
Sbjct: 2508 QVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLT 2567
Query: 2499 VARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLK 2558
+ RQ++LEES+++L FQ E+QL+ WL+EKELM+ VLGPLSIDPNMLN Q+QQVQ +L+
Sbjct: 2568 IDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQ 2627
Query: 2559 EFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ 2618
EF R+ Q+EQL A QGIL+ PG+ V+++L ++ QKW LT +L+ R IDQ
Sbjct: 2628 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2687
Query: 2619 AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 2678
AIVKSTQYQ LL+ LS+K+ + +LS A+ST P+A+ QQLE +++ +++Q ++
Sbjct: 2688 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI 2747
Query: 2679 KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 2738
K AQ LC++LS L+ E+YLK EL ++LE + + +E A + + LQ+A AS+ QFQQ
Sbjct: 2748 KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2807
Query: 2739 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 2798
M + + WLD K+ +Q K+ PISAKL+ L+S ++++++F K+L S YE +AEGE+L
Sbjct: 2808 MSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL 2867
Query: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858
LL G EK LQ QL +K +W+ +K+ +R+++LK+ ++KA KY+ VE L PWI+
Sbjct: 2868 LLKTQ-GSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID 2926
Query: 2859 DCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI 2918
C+ + E++ LDP + E+S+ + K++ E+++ ++E+LN+ A+ L++ E D++ +
Sbjct: 2927 KCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2986
Query: 2919 RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG 2978
DE + Q +D VTE+L +K LE MTQ+ +EFQE K +++++ AK QL+I D+LG
Sbjct: 2987 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLG 3046
Query: 2979 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3038
SQA SNK L L+ QQ+ LQAL+ QVD + Q LV +A D S +L Q E QE
Sbjct: 3047 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3106
Query: 3039 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3098
+ Q+V+ C +E KL+GIG F +REMFSQ A+ DDELD M +GRD ++LQ Q E
Sbjct: 3107 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3166
Query: 3099 DVRLFLNKIHVLKLDIEASEAECRHMLE-EEGTLDLLGLKRELEALNKQCGKLTERGKAR 3157
++ FL K+ L + + C+ ML EE + DL+G+KR+LEAL+KQC KL +R +AR
Sbjct: 3167 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3226
Query: 3158 QEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQV 3217
+EQ+E T+ R+E+FY KLK + AEE E Q VG E E INQQL FK+FQKE++
Sbjct: 3227 EEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3286
Query: 3218 DPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALL 3277
+PLQ K Q VN LGQGLIQSA K QGLEHD++++NARW TLNKKVAQR AQLQEALL
Sbjct: 3287 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 3346
Query: 3278 HCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDML 3337
HCG+FQDALE LLSW+ DTEEL+ANQKPPSAE+KVVKAQIQEQKLLQRLLDDRK+TV+++
Sbjct: 3347 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3406
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397
+ EG +IA +AE AD+ KI QL L+SRW LL+KA R +QLE I V+A+QFHET EP
Sbjct: 3407 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3466
Query: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLT 3457
++++L+ EK+L N EP+GTQ +K+++QI +HKALE+DI NH +HQAV IGQSL L+
Sbjct: 3467 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLS 3526
Query: 3458 SPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDK 3517
S ++ ++ K+D Q Y EIQ++ ++ LL QAL NA++FGEDEVE++NWL EV DK
Sbjct: 3527 SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDK 3586
Query: 3518 LSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK 3577
LS + V+D+ + L +Q ++ L E+I+ RK+NVDQA+ NG LLKQTTG+EVL+IQ+K
Sbjct: 3587 LSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDK 3646
Query: 3578 LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTG 3637
L+ IK RY DIT S+ +TLEQA QLA + ST+EEL WL +VE EL + Q G
Sbjct: 3647 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG 3706
Query: 3638 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLV 3697
E+ Q Q R KELKKE ++ +LD++NEVS ALLELVPWRAREGL+K+V++ NE+Y+LV
Sbjct: 3707 EEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLV 3766
Query: 3698 SDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK 3757
SDTI Q+V+EIDAAI RSQQ++QAADAEL+W+ ET++KLM+LG IRLEQDQT+AQLQVQK
Sbjct: 3767 SDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQK 3826
Query: 3758 AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARL 3817
F+++I+RHKD +D+L +I C EE+K +++K + +++ Y+ I +NSERY +L
Sbjct: 3827 TFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL 3886
Query: 3818 ERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKP 3877
ERAQ LVNQFWETYEEL PW+ ET+++I+QLP+PA+++E LRQQQEE RQLRE IAEHKP
Sbjct: 3887 ERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKP 3946
Query: 3878 HIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITE 3937
HIDK+ K GPQL EL+P EG ++EKY A+ +Y+QIKE+V++RA+ALDEA+SQSTQ
Sbjct: 3947 HIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ--- 4003
Query: 3938 FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRG 3997
FHDKI+ +LE+LE + RLR PP I AEV+KI+E IS+NK+ +V++EKLQP +E LK+RG
Sbjct: 4004 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRG 4063
Query: 3998 EELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAA 4057
EE+I RS G DKD++AK +QDKLDQMVF WE+I EERE K LDV+ELAEKFW D +
Sbjct: 4064 EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMS 4123
Query: 4058 LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC 4117
L+ TIKDTQD + DLE PGIDPS++KQQ EAAETI+EE DGL EEL+ + LG++LI AC
Sbjct: 4124 LIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC 4183
Query: 4118 GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIK 4177
GE +KP V+KSIDE+N+AW++LNK WK+R++KLE+AMQAAVQYQD LQA+FDW+D K
Sbjct: 4184 GEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGK 4243
Query: 4178 LCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIRE 4237
L +M P+GTDL TVK Q+ E+K+FK E YQQQIEME+LNHQ EL+LKK T+E+D+ +++
Sbjct: 4244 LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQD 4303
Query: 4238 PLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGD 4297
PL ELK +W++L E+I +RQHKLEGALLALGQFQHAL+EL++WLTHTE LL Q+P+ GD
Sbjct: 4304 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4363
Query: 4298 PKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWES 4357
PK IE+ELAKHHVL+NDVLAHQ+TVE VNKAGN+L+ESSAG++AS+L+++LE +NQ W++
Sbjct: 4364 PKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQN 4423
Query: 4358 VLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTH 4417
VL+KTE+R+QQL L+QA+GFH EIED LT E L ASKP GGLPETA+EQL+ H
Sbjct: 4424 VLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVH 4483
Query: 4418 MELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKS 4477
ME+ + +AKEETY L+ KG+ M L+R + + +Q + L++KW V +K+ ERK+
Sbjct: 4484 MEVCAAFEAKEETYKSLMQKGQQM-LARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4542
Query: 4478 KLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAH 4537
KLEEALNLA EF NSLQ+FINWLT AEQ+LN+AS PSLIL+TVL QI+EHKVFANEVN+H
Sbjct: 4543 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 4602
Query: 4538 RDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQ 4597
R+QIIELD+TG LK+ SQKQDVVLIKNLL+SVQSRWEKVVQR +ERGRSLDDARKRAKQ
Sbjct: 4603 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4662
Query: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTG 4657
FHEAW KL++WLE++E LDSELEI+NDPDKIK QL++HKEFQK+LG K VYDTT RTG
Sbjct: 4663 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4722
Query: 4658 RALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVD 4717
R+LKEKT L +D+ KLD+ L E+RDKWDT+CGKSVERQ+KLEEALLFSGQF DALQAL+D
Sbjct: 4723 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4782
Query: 4718 WLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDD 4777
WLY+VEPQLAEDQPVHGD+DLVMNL+D HK FQKELGKRT +VQ LKRS RELIE SRDD
Sbjct: 4783 WLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDD 4842
Query: 4778 TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFR 4837
++WVK Q+QELSTRW+TVC LS+SKQ+RLE AL+QAE F VH LLEWL+EAEQTLRF
Sbjct: 4843 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 4902
Query: 4838 GALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITII 4897
G LPDD +AL++LID HKEFMKK+EEKR ++N A MG+ +LA+CHPD ITTIKHWITII
Sbjct: 4903 GVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 4962
Query: 4898 RARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDR 4957
RARFEEVL WAKQHQQRL +AL+ L+A ELLE LLAW+QWAETTL +D+E IPQ I+
Sbjct: 4963 RARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEE 5022
Query: 4958 VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEP----THAPFIEKSRSGGRKSLSQP 5013
VKALIAEHQTFMEEMTRKQPDVD+VTKTYKR+ +P +H P ++K R+ GRK
Sbjct: 5023 VKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRA-GRKRFPAS 5081
Query: 5014 TPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVW 5073
+ P +Q E KNPR+N L ++WQQVWLLALER+RKLNDALDRLEEL+EFANFDFD+W
Sbjct: 5082 SLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIW 5141
Query: 5074 RKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDR 5133
RKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGIL+SKFPT++LEM+AVADIFDR
Sbjct: 5142 RKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDR 5201
Query: 5134 DGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYR- 5192
DGDGYIDYYEFVAALHPNKDAY+P TDADKIEDEVTRQVA+CKCAKRFQVEQIG+NKYR
Sbjct: 5202 DGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRF 5261
Query: 5193 -----FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILP 5247
FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRA+GRTN+ELREKFIL
Sbjct: 5262 FLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILA 5321
Query: 5248 EGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPAT----------- 5296
+GASQGM FR RGRRS+PSSR ASP RS+S +SQ+ + + P PAT
Sbjct: 5322 DGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAAS--PQVPATTTPKILHPLTR 5379
Query: 5297 ------------------------PASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNS 5332
P + P GSKL+ P + S + +G+ S
Sbjct: 5380 NYGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLR--LPGYLSGKGFHSGEDSGL 5437
Query: 5333 SSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTS-- 5390
+ A+ +T AD KK+ SRPGSRAGS+AGSRASSRRGSDASDFD+ E QS CSD
Sbjct: 5438 ITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETV 5497
Query: 5391 -ESSAAGGQGNSRRGLNKPSKIPTMSKKT 5418
++ + SR KPSKIPT +K+
Sbjct: 5498 PQTHRPTPRAGSRPSTAKPSKIPTPQRKS 5526
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 5941 bits (15413), Expect = 0.0
Identities = 3039/5549 (54%), Positives = 4065/5549 (73%), Gaps = 169/5549 (3%)
Query: 10 SERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQD-SVLDPAERA 68
S R S + S+ S++SGS SP P GDTLPWNLP HE+ KRK Q SVLDPAERA
Sbjct: 145 SYRCSMSSSADFSDEDDFSQKSGSASPAP-GDTLPWNLPKHERSKRKIQGGSVLDPAERA 203
Query: 69 VVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREK 128
V+R+ADERD+VQKKTFTKW+N+HLMKVRKH+NDLYEDLRDGHNLISLLEVLSG LPREK
Sbjct: 204 VLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREK 263
Query: 129 GRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYIS 188
GRMRFHRLQNVQIALD+LK+RQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI+++
Sbjct: 264 GRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVT 323
Query: 189 GESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQI 248
GES DMSAKE+LLLWTQ+ T GY GI+C NF++CW DGK+FNA+IH+YRPDL+DM V +
Sbjct: 324 GESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 383
Query: 249 QSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGIS 308
QSN NLE AF VAE++GV RLLD EDVDV SPDEKSVITYVSS+YDAFPKVPEGGEGI
Sbjct: 384 QSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIG 443
Query: 309 ATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKE 368
A +V+ +W EYQ+ V+ LI WI+ H MS++TFP NPVELKALYNQY+ FKETEI KE
Sbjct: 444 ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKE 503
Query: 369 REKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLEL 428
EK +I+ LYKLLE+WIEFGRIKL QGYHPND+E+EWGKLII MLEREK+LRP VERLE+
Sbjct: 504 TEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEM 563
Query: 429 LLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQ 488
L QIAN++Q ++ CE+KL LA N LQ+D+ LESG Q E+++ YI ECE L+RQ
Sbjct: 564 LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 623
Query: 489 VDLQILRDENYYQLEELAFRVMRLQDELVTLRLEC--------------TNLYRKGHFTS 534
+D+QIL D YYQ ++L RV +L+DE++ LR EC T L G S
Sbjct: 624 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQS 683
Query: 535 L-----ELVPPSTLT------TTHLKAEPLTKATHSSSTS-------------------- 563
L + + PS + T L + +T S TS
Sbjct: 684 LNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVP 743
Query: 564 -----------------WFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERA 606
RKP+ ++ L+ + +E+E N++FV +LL+WV+EMQ++L+R
Sbjct: 744 NFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRT 803
Query: 607 EWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYC 666
EWG+DLPSVE LE +++H ++EE SS+KEA++ E +M+ +YAE L +LE+QY
Sbjct: 804 EWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYA 863
Query: 667 KLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELT 726
KL TS + RHL +LH FVSRAT ELIWLNEKEEEE+AYDWS+ N+NI+ K++Y +EL
Sbjct: 864 KLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELM 923
Query: 727 MELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENT 786
EL++K++ +S+Q+ AE L LENHPA+ T+EAY AA+Q+Q W+ QLC CVEQH+KENT
Sbjct: 924 RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 983
Query: 787 AYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVA 846
AYF+FF+DA+E +LRNL+D+I+RKYSCD ++S+ +LEDL+Q+SM+EKE+L+Q KS++A
Sbjct: 984 AYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIA 1043
Query: 847 SLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVI 906
+L+G++KTI+QLKPR+ D LK +I +KA+CDYRQIEITI K+DECVL +NS R KWKVI
Sbjct: 1044 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVI 1103
Query: 907 SPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKD 966
SPTGNEAMVPSVCF +PPPNK+A+++A+R+EQ YQ V+ LWH+ H+N KS++SW+YL +
Sbjct: 1104 SPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINE 1163
Query: 967 LDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACK 1026
+D ++ N+ +++ PGE Q++ NLQ+ +EDFL+DS++S +FS +D +LE+EV CK
Sbjct: 1164 IDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK 1223
Query: 1027 ARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQD 1086
+Q L+KS E E++EE+V +YISE++NIRLRLE E R++++I++ +RD +
Sbjct: 1224 QYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT----PLERDDLHE 1279
Query: 1087 NALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVY 1146
+ RI EQE +++L++L+ DL ++ KC+ F Q+ +SSSVPTLRSELN++++ M+ VY
Sbjct: 1280 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1339
Query: 1147 GLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSD 1206
+S+ Y++KLKTV++++++ Q AE LVK YE KL +EE V+AD + +E STL+ W S+
Sbjct: 1340 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1399
Query: 1207 VKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIR 1266
V +K VF L++E+ KAK ++++M + ER+LD + ++EK QL ERW V Q++ R
Sbjct: 1400 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1459
Query: 1267 QSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEI 1326
+LE I + L YR + L WI++ Q ++ Q E+S+ L+ QL+QQ L +EI
Sbjct: 1460 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1519
Query: 1327 ERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFM 1386
E Q+K+D+CQK+++QYS VKDYELQ MTY+A V+SQQKSP KRRRM SS+D I QEFM
Sbjct: 1520 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1579
Query: 1387 DLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQ 1446
DLRTRYTALVTL TQ++K+ D+L+RLEEEEK +EEEK+EHVEK KEL WVS +++ +
Sbjct: 1580 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1639
Query: 1447 GKATSSETKESTDIEKA----ILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEK 1502
D EKA +Q++ SEE++TKKEQ+SEA++T Q+FLAKHG K++++
Sbjct: 1640 ------------DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDE 1687
Query: 1503 EKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSW 1562
E+ ++ +Q+ L ++Y+ L S QLQ+ Q+ + E+K + ++Q ++L+ +C
Sbjct: 1688 ERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDL 1747
Query: 1563 VGQAERALAGHQGRTTQQDLSA-LQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQ 1621
+ Q E L GHQ D + L+K QS ++LQ D+Q A + A VVK+ E F++EN
Sbjct: 1748 LTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENG 1807
Query: 1622 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 1681
KLS + + +KL++AK + E L + ++KEL++ VT+A+++ETEK A K+L E+
Sbjct: 1808 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEES 1867
Query: 1682 KKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG---------------ALDT-T 1725
K KI+ LLDW+++V + T + + +G ++G L+T
Sbjct: 1868 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1927
Query: 1726 DGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQML 1785
DG +G Q E L++Q + +KA+H++++SQ Q I+ATQSAQ L++ G L+PEE++ L
Sbjct: 1928 DGQVGTTQ--ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1985
Query: 1786 QQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGG 1845
Q+ + ELK Y T+LA+SE ++K +LQ+EL+KF D+ EFE WL++SE+ELEN+ G
Sbjct: 1986 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 2045
Query: 1846 SSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE---GK-EPSEIGNL 1901
L + LKRQ SFSEDVISHKGDLR++TISG +VL+ S + GK + S
Sbjct: 2046 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHRE 2105
Query: 1902 VKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSD 1961
V+ KL AT+R+ +L+SKC LG++L L+ +Y +++++ L A +QACEA K LS+
Sbjct: 2106 VQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSE 2165
Query: 1962 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS 2021
+A DP LQ QL TK LQ +++ QV VEKL+K A +++ G P +Q+T D
Sbjct: 2166 PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDD 2225
Query: 2022 ILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVI 2081
I+ ++ LS S+ ER+ LQ + +S SVQ+ L+ +L +G VE +L+ + L+S +
Sbjct: 2226 IVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTAL 2285
Query: 2082 QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQ 2141
Q+ ++ N+ L+QDIA ++SS+ A E V +FMET D +TA+ LQ K+ ++S RF + +
Sbjct: 2286 QDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2345
Query: 2142 QQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEM 2201
+E + +++L + E+FE+LS KLQ F+E K++ L + P +D+T Q +QE E
Sbjct: 2346 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEF 2405
Query: 2202 EDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQ 2261
+ +++L+ L L+ E+SS G D ++ NL K F E++ T+KE+++ +SCQEQ
Sbjct: 2406 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQ 2465
Query: 2262 LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINC 2321
LD F+ LV++ + W+KET +P + S A++L K +E K L + W+ K ++++N
Sbjct: 2466 LDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2525
Query: 2322 KGTSLENLIMEITAPD---SQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK 2378
G SL NLI +T P + K+G + + + + + K LT I+ DM+D++
Sbjct: 2526 SGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHG 2585
Query: 2379 YEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA 2438
YE LG +L ++ L L+++++ +E+++++QWL+ + +PT TE VK
Sbjct: 2586 YEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKT 2645
Query: 2439 QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVT 2498
Q E NK+F AEL+QN K+Q++K+ L LL P++ EA WK++ E++S+W+ ++T
Sbjct: 2646 QVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLT 2705
Query: 2499 VARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLK 2558
+ RQ++LEES+++L FQ E+QL+ WL+EKELM+ VLGPLSIDPNMLN Q+QQVQ +L+
Sbjct: 2706 IDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQ 2765
Query: 2559 EFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ 2618
EF R+ Q+EQL A QGIL+ PG+ V+++L ++ QKW LT +L+ R IDQ
Sbjct: 2766 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2825
Query: 2619 AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 2678
AIVKSTQYQ LL+ LS+K+ + +LS A+ST P+A+ QQLE +++ +++Q ++
Sbjct: 2826 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI 2885
Query: 2679 KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 2738
K AQ LC++LS L+ E+YLK EL ++LE + + +E A + + LQ+A AS+ QFQQ
Sbjct: 2886 KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2945
Query: 2739 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 2798
M + + WLD K+ +Q K+ PISAKL+ L+S ++++++F K+L S YE +AEGE+L
Sbjct: 2946 MSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL 3005
Query: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858
LL G EK LQ QL +K +W+ +K+ +R+++LK+ ++KA KY+ VE L PWI+
Sbjct: 3006 LLKTQ-GSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID 3064
Query: 2859 DCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI 2918
C+ + E++ LDP + E+S+ + K++ E+++ ++E+LN+ A+ L++ E D++ +
Sbjct: 3065 KCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 3124
Query: 2919 RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG 2978
DE + Q +D VTE+L +K LE MTQ+ +EFQE K +++++ AK QL+I D+LG
Sbjct: 3125 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLG 3184
Query: 2979 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3038
SQA SNK L L+ QQ+ LQAL+ QVD + Q LV +A D S +L Q E QE
Sbjct: 3185 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3244
Query: 3039 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3098
+ Q+V+ C +E KL+GIG F +REMFSQ A+ DDELD M +GRD ++LQ Q E
Sbjct: 3245 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3304
Query: 3099 DVRLFLNKIHVLKLDIEASEAECRHMLE-EEGTLDLLGLKRELEALNKQCGKLTERGKAR 3157
++ FL K+ L + + C+ ML EE + DL+G+KR+LEAL+KQC KL +R +AR
Sbjct: 3305 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3364
Query: 3158 QEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQV 3217
+EQ+E T+ R+E+FY KLK + AEE E Q VG E E INQQL FK+FQKE++
Sbjct: 3365 EEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3424
Query: 3218 DPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALL 3277
+PLQ K Q VN LGQGLIQSA K QGLEHD++++NARW TLNKKVAQR AQLQEALL
Sbjct: 3425 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 3484
Query: 3278 HCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDML 3337
HCG+FQDALE LLSW+ DTEEL+ANQKPPSAE+KVVKAQIQEQKLLQRLLDDRK+TV+++
Sbjct: 3485 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3544
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397
+ EG +IA +AE AD+ KI QL L+SRW LL+KA R +QLE I V+A+QFHET EP
Sbjct: 3545 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3604
Query: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLT 3457
++++L+ EK+L N EP+GTQ +K+++QI +HKALE+DI NH +HQAV IGQSL L+
Sbjct: 3605 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLS 3664
Query: 3458 SPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDK 3517
S ++ ++ K+D Q Y EIQ++ ++ LL QAL NA++FGEDEVE++NWL EV DK
Sbjct: 3665 SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDK 3724
Query: 3518 LSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK 3577
LS + V+D+ + L +Q ++ L E+I+ RK+NVDQA+ NG LLKQTTG+EVL+IQ+K
Sbjct: 3725 LSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDK 3784
Query: 3578 LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTG 3637
L+ IK RY DIT S+ +TLEQA QLA + ST+EEL WL +VE EL + Q G
Sbjct: 3785 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG 3844
Query: 3638 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLV 3697
E+ Q Q R KELKKE ++ +LD++NEVS ALLELVPWRAREGL+K+V++ NE+Y+LV
Sbjct: 3845 EEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLV 3904
Query: 3698 SDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK 3757
SDTI Q+V+EIDAAI RSQQ++QAADAEL+W+ ET++KLM+LG IRLEQDQT+AQLQVQK
Sbjct: 3905 SDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQK 3964
Query: 3758 AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARL 3817
F+++I+RHKD +D+L +I C EE+K +++K + +++ Y+ I +NSERY +L
Sbjct: 3965 TFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL 4024
Query: 3818 ERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKP 3877
ERAQ LVNQFWETYEEL PW+ ET+++I+QLP+PA+++E LRQQQEE RQLRE IAEHKP
Sbjct: 4025 ERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKP 4084
Query: 3878 HIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITE 3937
HIDK+ K GPQL EL+P EG ++EKY A+ +Y+QIKE+V++RA+ALDEA+SQSTQ
Sbjct: 4085 HIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ--- 4141
Query: 3938 FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRG 3997
FHDKI+ +LE+LE + RLR PP I AEV+KI+E IS+NK+ +V++EKLQP +E LK+RG
Sbjct: 4142 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRG 4201
Query: 3998 EELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAA 4057
EE+I RS G DKD++AK +QDKLDQMVF WE+I EERE K LDV+ELAEKFW D +
Sbjct: 4202 EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMS 4261
Query: 4058 LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC 4117
L+ TIKDTQD + DLE PGIDPS++KQQ EAAETI+EE DGL EEL+ + LG++LI AC
Sbjct: 4262 LIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC 4321
Query: 4118 GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIK 4177
GE +KP V+KSIDE+N+AW++LNK WK+R++KLE+AMQAAVQYQD LQA+FDW+D K
Sbjct: 4322 GEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGK 4381
Query: 4178 LCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIRE 4237
L +M P+GTDL TVK Q+ E+K+FK E YQQQIEME+LNHQ EL+LKK T+E+D+ +++
Sbjct: 4382 LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQD 4441
Query: 4238 PLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGD 4297
PL ELK +W++L E+I +RQHKLEGALLALGQFQHAL+EL++WLTHTE LL Q+P+ GD
Sbjct: 4442 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4501
Query: 4298 PKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWES 4357
PK IE+ELAKHHVL+NDVLAHQ+TVE VNKAGN+L+ESSAG++AS+L+++LE +NQ W++
Sbjct: 4502 PKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQN 4561
Query: 4358 VLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTH 4417
VL+KTE+R+QQL L+QA+GFH EIED LT E L ASKP GGLPETA+EQL+ H
Sbjct: 4562 VLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVH 4621
Query: 4418 MELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKS 4477
ME+ + +AKEETY L+ KG+ M L+R + + +Q + L++KW V +K+ ERK+
Sbjct: 4622 MEVCAAFEAKEETYKSLMQKGQQM-LARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4680
Query: 4478 KLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAH 4537
KLEEALNLA EF NSLQ+FINWLT AEQ+LN+AS PSLIL+TVL QI+EHKVFANEVN+H
Sbjct: 4681 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 4740
Query: 4538 RDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQ 4597
R+QIIELD+TG LK+ SQKQDVVLIKNLL+SVQSRWEKVVQR +ERGRSLDDARKRAKQ
Sbjct: 4741 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4800
Query: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTG 4657
FHEAW KL++WLE++E LDSELEI+NDPDKIK QL++HKEFQK+LG K VYDTT RTG
Sbjct: 4801 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4860
Query: 4658 RALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVD 4717
R+LKEKT L +D+ KLD+ L E+RDKWDT+CGKSVERQ+KLEEALLFSGQF DALQAL+D
Sbjct: 4861 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4920
Query: 4718 WLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDD 4777
WLY+VEPQLAEDQPVHGD+DLVMNL+D HK FQKELGKRT +VQ LKRS RELIE SRDD
Sbjct: 4921 WLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDD 4980
Query: 4778 TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFR 4837
++WVK Q+QELSTRW+TVC LS+SKQ+RLE AL+QAE F VH LLEWL+EAEQTLRF
Sbjct: 4981 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 5040
Query: 4838 GALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITII 4897
G LPDD +AL++LID HKEFMKK+EEKR ++N A MG+ +LA+CHPD ITTIKHWITII
Sbjct: 5041 GVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 5100
Query: 4898 RARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDR 4957
RARFEEVL WAKQHQQRL +AL+ L+A ELLE LLAW+QWAETTL +D+E IPQ I+
Sbjct: 5101 RARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEE 5160
Query: 4958 VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEP----THAPFIEKSRSGGRKSLSQP 5013
VKALIAEHQTFMEEMTRKQPDVD+VTKTYKR+ +P +H P ++K R+ GRK
Sbjct: 5161 VKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRA-GRKRFPAS 5219
Query: 5014 TPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVW 5073
+ P +Q E KNPR+N L ++WQQVWLLALER+RKLNDALDRLEEL+EFANFDFD+W
Sbjct: 5220 SLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIW 5279
Query: 5074 RKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDR 5133
RKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGIL+SKFPT++LEM+AVADIFDR
Sbjct: 5280 RKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDR 5339
Query: 5134 DGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYR- 5192
DGDGYIDYYEFVAALHPNKDAY+P TDADKIEDEVTRQVA+CKCAKRFQVEQIG+NKYR
Sbjct: 5340 DGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRF 5399
Query: 5193 -----FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILP 5247
FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRA+GRTN+ELREKFIL
Sbjct: 5400 FLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILA 5459
Query: 5248 EGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPAT----------- 5296
+GASQGM FR RGRRS+PSSR ASP RS+S +SQ+ + + P PAT
Sbjct: 5460 DGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAAS--PQVPATTTPKILHPLTR 5517
Query: 5297 ------------------------PASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNS 5332
P + P GSKL+ P + S + +G+ S
Sbjct: 5518 NYGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLR--LPGYLSGKGFHSGEDSGL 5575
Query: 5333 SSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTS-- 5390
+ A+ +T AD KK+ SRPGSRAGS+AGSRASSRRGSDASDFD+ E QS CSD
Sbjct: 5576 ITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETV 5635
Query: 5391 -ESSAAGGQGNSRRGLNKPSKIPTMSKKT 5418
++ + SR KPSKIPT +K+
Sbjct: 5636 PQTHRPTPRAGSRPSTAKPSKIPTPQRKS 5664
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 5940 bits (15411), Expect = 0.0
Identities = 3035/5531 (54%), Positives = 4059/5531 (73%), Gaps = 169/5531 (3%)
Query: 28 SERSGSLSPCPPGDTLPWNLPLHEQKKRKSQD-SVLDPAERAVVRVADERDRVQKKTFTK 86
S++SGS SP P GDTLPWNLP HE+ KRK Q SVLDPAERAV+R+ADERD+VQKKTFTK
Sbjct: 14 SQKSGSASPAP-GDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIADERDKVQKKTFTK 72
Query: 87 WVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFL 146
W+N+HLMKVRKH+NDLYEDLRDGHNLISLLEVLSG LPREKGRMRFHRLQNVQIALD+L
Sbjct: 73 WINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYL 132
Query: 147 KQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGDMSAKEKLLLWTQK 206
K+RQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI+++GES DMSAKE+LLLWTQ+
Sbjct: 133 KRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQ 192
Query: 207 VTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLG 266
T GY GI+C NF++CW DGK+FNA+IH+YRPDL+DM V +QSN NLE AF VAE++G
Sbjct: 193 ATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIG 252
Query: 267 VTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSL 326
V RLLD EDVDV SPDEKSVITYVSS+YDAFPKVPEGGEGI A +V+ +W EYQ+ V+ L
Sbjct: 253 VIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYL 312
Query: 327 IPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLEVWIE 386
I WI+ H MS++TFP NPVELKALYNQY+ FKETEI KE EK +I+ LYKLLE+WIE
Sbjct: 313 IQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIE 372
Query: 387 FGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEK 446
FGRIKL QGYHPND+E+EWGKLII MLEREK+LRP VERLE+L QIAN++Q ++ CE+K
Sbjct: 373 FGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDK 432
Query: 447 LTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELA 506
L LA N LQ+D+ LESG Q E+++ YI ECE L+RQ +D+QIL D YYQ ++L
Sbjct: 433 LILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLV 492
Query: 507 FRVMRLQDELVTLRLEC--------------TNLYRKGHFTSL-----ELVPPSTLT--- 544
RV +L+DE++ LR EC T L G SL + + PS +
Sbjct: 493 QRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLT 552
Query: 545 ---TTHLKAEPLTKATHSSSTS-------------------------------------W 564
T L + +T S TS
Sbjct: 553 QSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQ 612
Query: 565 FRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQH 624
RKP+ ++ L+ + +E+E N++FV +LL+WV+EMQ++L+R EWG+DLPSVE LE ++
Sbjct: 613 IRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKN 672
Query: 625 IHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHK 684
+H ++EE SS+KEA++ E +M+ +YAE L +LE+QY KL TS + RHL +LH
Sbjct: 673 VHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHN 732
Query: 685 FVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAE 744
FVSRAT ELIWLNEKEEEE+AYDWS+ N+NI+ K++Y +EL EL++K++ +S+Q+ AE
Sbjct: 733 FVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAE 792
Query: 745 LLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRN 804
L LENHPA+ T+EAY AA+Q+Q W+ QLC CVEQH+KENTAYF+FF+DA+E +LRN
Sbjct: 793 QLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRN 852
Query: 805 LQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPD 864
L+D+I+RKYSCD ++S+ +LEDL+Q+SM+EKE+L+Q KS++A+L+G++KTI+QLKPR+ D
Sbjct: 853 LKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSD 912
Query: 865 HVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPP 924
LK +I +KA+CDYRQIEITI K+DECVL +NS R KWKVISPTGNEAMVPSVCF +PP
Sbjct: 913 CPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPP 972
Query: 925 PNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPG 984
PNK+A+++A+R+EQ YQ V+ LWH+ H+N KS++SW+YL ++D ++ N+ +++ PG
Sbjct: 973 PNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPG 1032
Query: 985 ECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEET 1044
E Q++ NLQ+ +EDFL+DS++S +FS +D +LE+EV CK +Q L+KS E E++EE+
Sbjct: 1033 EHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEES 1092
Query: 1045 VAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQL 1104
V +YISE++NIRLRLE E R++++I++ +RD ++ RI EQE +++L++L
Sbjct: 1093 VYNLYISEVRNIRLRLENCEDRLIRQIRT----PLERDDLHESVFRITEQEKLKKELERL 1148
Query: 1105 RSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVR 1164
+ DL ++ KC+ F Q+ +SSSVPTLRSELN++++ M+ VY +S+ Y++KLKTV+++++
Sbjct: 1149 KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLK 1208
Query: 1165 SIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKA 1224
+ Q AE LVK YE KL +EE V+AD + +E STL+ W S+V +K VF L++E+ KA
Sbjct: 1209 NTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 1268
Query: 1225 KVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACH 1284
K ++++M + ER+LD + ++EK QL ERW V Q++ R +LE I + L YR +
Sbjct: 1269 KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 1328
Query: 1285 GTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYS 1344
L WI++ Q ++ Q E+S+ L+ QL+QQ L +EIE Q+K+D+CQK+++QYS
Sbjct: 1329 HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYS 1388
Query: 1345 TIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVK 1404
VKDYELQ MTY+A V+SQQKSP KRRRM SS+D I QEFMDLRTRYTALVTL TQ++K
Sbjct: 1389 ATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIK 1448
Query: 1405 YISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKA- 1463
+ D+L+RLEEEEK +EEEK+EHVEK KEL WVS +++ + D EKA
Sbjct: 1449 FAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK------------DAEKAG 1496
Query: 1464 ---ILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHD 1520
+Q++ SEE++TKKEQ+SEA++T Q+FLAKHG K++++E+ ++ +Q+ L ++Y+
Sbjct: 1497 KPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNL 1556
Query: 1521 LCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQ 1580
L S QLQ+ Q+ + E+K + ++Q ++L+ +C + Q E L GHQ
Sbjct: 1557 LFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIG 1616
Query: 1581 DLSA-LQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQA 1639
D + L+K QS ++LQ D+Q A + A VVK+ E F++EN KLS + + +KL++A
Sbjct: 1617 DGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEA 1676
Query: 1640 KEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSG 1699
K + E L + ++KEL++ VT+A+++ETEK A K+L E+K KI+ LLDW+++V
Sbjct: 1677 KIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDS 1736
Query: 1700 GQLLTNLPGMEQLSGASLEKG---------------ALDT-TDGYMGVNQAPEKLDKQCE 1743
+ T + + +G ++G L+T DG +G Q E L++Q +
Sbjct: 1737 ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ--ENLNQQYQ 1794
Query: 1744 MMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQS 1803
+KA+H++++SQ Q I+ATQSAQ L++ G L+PEE++ LQ+ + ELK Y T+LA+S
Sbjct: 1795 KVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAES 1854
Query: 1804 EAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSE 1863
E ++K +LQ+EL+KF D+ EFE WL++SE+ELEN+ G L + LKRQ SFSE
Sbjct: 1855 EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSE 1914
Query: 1864 DVISHKGDLRFVTISGQKVLDMENSFKE---GK-EPSEIGNLVKDKLKDATERYTALHSK 1919
DVISHKGDLR++TISG +VL+ S + GK + S V+ KL AT+R+ +L+SK
Sbjct: 1915 DVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSK 1974
Query: 1920 CTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQ 1979
C LG++L L+ +Y +++++ L A +QACEA K LS+ +A DP LQ QL TK
Sbjct: 1975 CNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA 2034
Query: 1980 LQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSL 2039
LQ +++ QV VEKL+K A +++ G P +Q+T D I+ ++ LS S+ ER+
Sbjct: 2035 LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK 2094
Query: 2040 LQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQK 2099
LQ + +S SVQ+ L+ +L +G VE +L+ + L+S +Q+ ++ N+ L+QDIA ++
Sbjct: 2095 LQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQ 2154
Query: 2100 SSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMF 2159
SS+ A E V +FMET D +TA+ LQ K+ ++S RF + + +E + +++L + E+F
Sbjct: 2155 SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELF 2214
Query: 2160 EHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELS 2219
E+LS KLQ F+E K++ L + P +D+T Q +QE E + +++L+ L L+ E+S
Sbjct: 2215 ENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEIS 2274
Query: 2220 SCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKET 2279
S G D ++ NL K F E++ T+KE+++ +SCQEQLD F+ LV++ + W+KET
Sbjct: 2275 SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2334
Query: 2280 EGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPD-- 2337
+P + S A++L K +E K L + W+ K ++++N G SL NLI +T P
Sbjct: 2335 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKA 2394
Query: 2338 -SQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAI 2396
+ K+G + + + + + K LT I+ DM+D++ YE LG +L ++ L
Sbjct: 2395 IAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTK 2454
Query: 2397 LNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK 2456
L+++++ +E+++++QWL+ + +PT TE VK Q E NK+F AEL+QN K
Sbjct: 2455 LSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNK 2514
Query: 2457 IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQ 2516
+Q++K+ L LL P++ EA WK++ E++S+W+ ++T+ RQ++LEES+++L FQ
Sbjct: 2515 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2574
Query: 2517 AAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQG 2576
E+QL+ WL+EKELM+ VLGPLSIDPNMLN Q+QQVQ +L+EF R+ Q+EQL A QG
Sbjct: 2575 TVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2634
Query: 2577 ILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEK 2636
IL+ PG+ V+++L ++ QKW LT +L+ R IDQAIVKSTQYQ LL+ LS+K
Sbjct: 2635 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2694
Query: 2637 VRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY 2696
+ + +LS A+ST P+A+ QQLE +++ +++Q ++K AQ LC++LS L+ E+Y
Sbjct: 2695 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2754
Query: 2697 LKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAK 2756
LK EL ++LE + + +E A + + LQ+A AS+ QFQQM + + WLD K+ +Q K
Sbjct: 2755 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2814
Query: 2757 NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLV 2816
+ PISAKL+ L+S ++++++F K+L S YE +AEGE+LLL G EK LQ QL
Sbjct: 2815 SHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQ-GSEKAALQLQLN 2873
Query: 2817 ELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQL 2876
+K +W+ +K+ +R+++LK+ ++KA KY+ VE L PWI+ C+ + E++ LDP +
Sbjct: 2874 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 2933
Query: 2877 ESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEEL 2936
E+S+ + K++ E+++ ++E+LN+ A+ L++ E D++ + DE + Q +D VTE+L
Sbjct: 2934 ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQL 2993
Query: 2937 QAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEV 2996
+K LE MTQ+ +EFQE K +++++ AK QL+I D+LGSQA SNK L L+ QQ+
Sbjct: 2994 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3053
Query: 2997 LQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKL 3056
LQAL+ QVD + Q LV +A D S +L Q E QE + Q+V+ C +E KL
Sbjct: 3054 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3113
Query: 3057 EGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEA 3116
+GIG F +REMFSQ A+ DDELD M +GRD ++LQ Q E ++ FL K+ L +
Sbjct: 3114 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3173
Query: 3117 SEAECRHMLE-EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKL 3175
+ C+ ML EE + DL+G+KR+LEAL+KQC KL +R +AR+EQ+E T+ R+E+FY KL
Sbjct: 3174 ANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3233
Query: 3176 KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLI 3235
K + AEE E Q VG E E INQQL FK+FQKE+++PLQ K Q VN LGQGLI
Sbjct: 3234 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3293
Query: 3236 QSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLAD 3295
QSA K QGLEHD++++NARW TLNKKVAQR AQLQEALLHCG+FQDALE LLSW+ D
Sbjct: 3294 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3353
Query: 3296 TEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREK 3355
TEEL+ANQKPPSAE+KVVKAQIQEQKLLQRLLDDRK+TV++++ EG +IA +AE AD+ K
Sbjct: 3354 TEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK 3413
Query: 3356 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3415
I QL L+SRW LL+KA R +QLE I V+A+QFHET EP++++L+ EK+L N EP+
Sbjct: 3414 ILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPI 3473
Query: 3416 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQAR 3475
GTQ +K+++QI +HKALE+DI NH +HQAV IGQSL L+S ++ ++ K+D Q
Sbjct: 3474 GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW 3533
Query: 3476 YSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQH 3535
Y EIQ++ ++ LL QAL NA++FGEDEVE++NWL EV DKLS + V+D+ + L +Q
Sbjct: 3534 YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQ 3593
Query: 3536 ADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKA 3595
++ L E+I+ RK+NVDQA+ NG LLKQTTG+EVL+IQ+KL+ IK RY DIT S+
Sbjct: 3594 SELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDV 3653
Query: 3596 LRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM 3655
+TLEQA QLA + ST+EEL WL +VE EL + Q GE+ Q Q R KELKKE
Sbjct: 3654 AKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAK 3713
Query: 3656 EHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS 3715
++ +LD++NEVS ALLELVPWRAREGL+K+V++ NE+Y+LVSDTI Q+V+EIDAAI RS
Sbjct: 3714 NNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3773
Query: 3716 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFS 3775
QQ++QAADAEL+W+ ET++KLM+LG IRLEQDQT+AQLQVQK F+++I+RHKD +D+L
Sbjct: 3774 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3833
Query: 3776 HRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELS 3835
+I C EE+K +++K + +++ Y+ I +NSERY +LERAQ LVNQFWETYEEL
Sbjct: 3834 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 3893
Query: 3836 PWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPE 3895
PW+ ET+++I+QLP+PA+++E LRQQQEE RQLRE IAEHKPHIDK+ K GPQL EL+P
Sbjct: 3894 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3953
Query: 3896 EGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSR 3955
EG ++EKY A+ +Y+QIKE+V++RA+ALDEA+SQSTQ FHDKI+ +LE+LE + R
Sbjct: 3954 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ---FHDKIDQILESLERIVER 4010
Query: 3956 LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE 4015
LR PP I AEV+KI+E IS+NK+ +V++EKLQP +E LK+RGEE+I RS G DKD++AK
Sbjct: 4011 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4070
Query: 4016 IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP 4075
+QDKLDQMVF WE+I EERE K LDV+ELAEKFW D +L+ TIKDTQD + DLE P
Sbjct: 4071 VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP 4130
Query: 4076 GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA 4135
GIDPS++KQQ EAAETI+EE DGL EEL+ + LG++LI ACGE +KP V+KSIDE+N+A
Sbjct: 4131 GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSA 4190
Query: 4136 WENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQL 4195
W++LNK WK+R++KLE+AMQAAVQYQD LQA+FDW+D KL +M P+GTDL TVK Q+
Sbjct: 4191 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI 4250
Query: 4196 NEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAH 4255
E+K+FK E YQQQIEME+LNHQ EL+LKK T+E+D+ +++PL ELK +W++L E+I +
Sbjct: 4251 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4310
Query: 4256 RQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDV 4315
RQHKLEGALLALGQFQHAL+EL++WLTHTE LL Q+P+ GDPK IE+ELAKHHVL+NDV
Sbjct: 4311 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4370
Query: 4316 LAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQ 4375
LAHQ+TVE VNKAGN+L+ESSAG++AS+L+++LE +NQ W++VL+KTE+R+QQL L+Q
Sbjct: 4371 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4430
Query: 4376 AQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLL 4435
A+GFH EIED LT E L ASKP GGLPETA+EQL+ HME+ + +AKEETY L+
Sbjct: 4431 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4490
Query: 4436 DKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQE 4495
KG+ M L+R + + +Q + L++KW V +K+ ERK+KLEEALNLA EF NSLQ+
Sbjct: 4491 QKGQQM-LARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQD 4549
Query: 4496 FINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS 4555
FINWLT AEQ+LN+AS PSLIL+TVL QI+EHKVFANEVN+HR+QIIELD+TG LK+ S
Sbjct: 4550 FINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFS 4609
Query: 4556 QKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESH 4615
QKQDVVLIKNLL+SVQSRWEKVVQR +ERGRSLDDARKRAKQFHEAW KL++WLE++E
Sbjct: 4610 QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKS 4669
Query: 4616 LDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDN 4675
LDSELEI+NDPDKIK QL++HKEFQK+LG K VYDTT RTGR+LKEKT L +D+ KLD+
Sbjct: 4670 LDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDD 4729
Query: 4676 FLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGD 4735
L E+RDKWDT+CGKSVERQ+KLEEALLFSGQF DALQAL+DWLY+VEPQLAEDQPVHGD
Sbjct: 4730 MLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD 4789
Query: 4736 LDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTV 4795
+DLVMNL+D HK FQKELGKRT +VQ LKRS RELIE SRDD++WVK Q+QELSTRW+TV
Sbjct: 4790 IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4849
Query: 4796 CKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHK 4855
C LS+SKQ+RLE AL+QAE F VH LLEWL+EAEQTLRF G LPDD +AL++LID HK
Sbjct: 4850 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 4909
Query: 4856 EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRL 4915
EFMKK+EEKR ++N A MG+ +LA+CHPD ITTIKHWITIIRARFEEVL WAKQHQQRL
Sbjct: 4910 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 4969
Query: 4916 ETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRK 4975
+AL+ L+A ELLE LLAW+QWAETTL +D+E IPQ I+ VKALIAEHQTFMEEMTRK
Sbjct: 4970 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 5029
Query: 4976 QPDVDRVTKTYKRKNIEP----THAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRI 5031
QPDVD+VTKTYKR+ +P +H P ++K R+ GRK + P +Q E KNPR+
Sbjct: 5030 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRA-GRKRFPASSLYPSGSQTQIETKNPRV 5088
Query: 5032 NQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDF 5091
N L ++WQQVWLLALER+RKLNDALDRLEEL+EFANFDFD+WRKKYMRWMNHKKSRVMDF
Sbjct: 5089 NLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDF 5148
Query: 5092 FRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPN 5151
FRRIDKDQDGKITRQEFIDGIL+SKFPT++LEM+AVADIFDRDGDGYIDYYEFVAALHPN
Sbjct: 5149 FRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPN 5208
Query: 5152 KDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYR------FGDSQQLRLVRIL 5205
KDAY+P TDADKIEDEVTRQVA+CKCAKRFQVEQIG+NKYR FGDSQQLRLVRIL
Sbjct: 5209 KDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRIL 5268
Query: 5206 RSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSK 5265
RSTVMVRVGGGWMALDEFLVKNDPCRA+GRTN+ELREKFIL +GASQGM FR RGRRS+
Sbjct: 5269 RSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSR 5328
Query: 5266 PSSRAASPTRSSSSASQSNHSCTSMPSSPAT----------------------------- 5296
PSSR ASP RS+S +SQ+ + + P PAT
Sbjct: 5329 PSSRGASPNRSTSVSSQAAQAAS--PQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKA 5386
Query: 5297 ------PASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKS 5350
P + P GSKL+ P + S + +G+ S + A+ +T AD KK+
Sbjct: 5387 AECSDFPVPSAEGTPIQGSKLR--LPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKT 5444
Query: 5351 ASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTS---ESSAAGGQGNSRRGLNK 5407
SRPGSRAGS+AGSRASSRRGSDASDFD+ E QS CSD ++ + SR K
Sbjct: 5445 PSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAK 5504
Query: 5408 PSKIPTMSKKT 5418
PSKIPT +K+
Sbjct: 5505 PSKIPTPQRKS 5515
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 5881 bits (15258), Expect = 0.0
Identities = 3004/5500 (54%), Positives = 4025/5500 (73%), Gaps = 167/5500 (3%)
Query: 58 QDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLE 117
+ L E + R DERD+VQKKTFTKW+N+HLMKVRKH+NDLYEDLRDGHNLISLLE
Sbjct: 15 EQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLE 74
Query: 118 VLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTII 177
VLSG LPREKGRMRFHRLQNVQIALD+LK+RQVKLVNIRNDDITDGNPKLTLGLIWTII
Sbjct: 75 VLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTII 134
Query: 178 LHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYR 237
LHFQISDI+++GES DMSAKE+LLLWTQ+ T GY GI+C NF++CW DGK+FNA+IH+YR
Sbjct: 135 LHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYR 194
Query: 238 PDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAF 297
PDL+DM V +QSN NLE AF VAE++GV RLLD EDVDV SPDEKSVITYVSS+YDAF
Sbjct: 195 PDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAF 254
Query: 298 PKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYI 357
PKVPEGGEGI A +V+ +W EYQ+ V+ LI WI+ H MS++TFP NPVELKALYNQY+
Sbjct: 255 PKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYL 314
Query: 358 HFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREK 417
FKETEI KE EK +I+ LYKLLE+WIEFGRIKL QGYHPND+E+EWGKLII MLEREK
Sbjct: 315 QFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREK 374
Query: 418 SLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYI 477
+LRP VERLE+L QIAN++Q ++ CE+KL LA N LQ+D+ LESG Q E+++ YI
Sbjct: 375 ALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYI 434
Query: 478 QECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLEC-------------- 523
ECE L+RQ +D+QIL D YYQ ++L RV +L+DE++ LR EC
Sbjct: 435 LECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQ 494
Query: 524 TNLYRKGHFTSL-----ELVPPSTLT------TTHLKAEPLTKATHSSSTS--------- 563
T L G SL + + PS + T L + +T S TS
Sbjct: 495 TKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPA 554
Query: 564 ----------------------------WFRKPMTRAELVAISSSEDEGNLRFVYELLSW 595
RKP+ ++ L+ + +E+E N++FV +LL+W
Sbjct: 555 YTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNW 614
Query: 596 VEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYA 655
V+EMQ++L+R EWG+DLPSVE LE +++H ++EE SS+KEA++ E +M+ +YA
Sbjct: 615 VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA 674
Query: 656 ETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNI 715
E L +LE+QY KL TS + RHL +LH FVSRAT ELIWLNEKEEEE+AYDWS+ N+NI
Sbjct: 675 EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 734
Query: 716 SAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLC 775
+ K++Y +EL EL++K++ +S+Q+ AE L LENHPA+ T+EAY AA+Q+Q W+ QLC
Sbjct: 735 ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLC 794
Query: 776 LCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEK 835
CVEQH+KENTAYF+FF+DA+E +LRNL+D+I+RKYSCD ++S+ +LEDL+Q+SM+EK
Sbjct: 795 QCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEK 854
Query: 836 EQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLE 895
E+L+Q KS++A+L+G++KTI+QLKPR+ D LK +I +KA+CDYRQIEITI K+DECVL
Sbjct: 855 EELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLA 914
Query: 896 DNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTK 955
+NS R KWKVISPTGNEAMVPSVCF +PPPNK+A+++A+R+EQ YQ V+ LWH+ H+N K
Sbjct: 915 NNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMK 974
Query: 956 SLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADR 1015
S++SW+YL ++D ++ N+ +++ PGE Q++ NLQ+ +EDFL+DS++S +FS +D
Sbjct: 975 SVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDI 1034
Query: 1016 LRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLA 1075
+LE+EV CK +Q L+KS E E++EE+V +YISE++NIRLRLE E R++++I++
Sbjct: 1035 TQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT-- 1092
Query: 1076 SSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSEL 1135
+RD ++ RI EQE +++L++L+ DL ++ KC+ F Q+ +SSSVPTLRSEL
Sbjct: 1093 --PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 1150
Query: 1136 NLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEA 1195
N++++ M+ VY +S+ Y++KLKTV++++++ Q AE LVK YE KL +EE V+AD + +E
Sbjct: 1151 NVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIEN 1210
Query: 1196 HWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQER 1255
STL+ W S+V +K VF L++E+ KAK ++++M + ER+LD + ++EK QL ER
Sbjct: 1211 LISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVER 1270
Query: 1256 WHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQ 1315
W V Q++ R +LE I + L YR + L WI++ Q ++ Q E+S+ L+ Q
Sbjct: 1271 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1330
Query: 1316 LSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRML 1375
L+QQ L +EIE Q+K+D+CQK+++QYS VKDYELQ MTY+A V+SQQKSP KRRRM
Sbjct: 1331 LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ 1390
Query: 1376 SSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELL 1435
SS+D I QEFMDLRTRYTALVTL TQ++K+ D+L+RLEEEEK +EEEK+EHVEK KEL
Sbjct: 1391 SSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQ 1450
Query: 1436 GWVSTLARNTQGKATSSETKESTDIEKA----ILEQQVLSEELTTKKEQVSEAIKTSQIF 1491
WVS +++ + D EKA +Q++ SEE++TKKEQ+SEA++T Q+F
Sbjct: 1451 KWVSNISKTLK------------DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLF 1498
Query: 1492 LAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNT 1551
LAKHG K++++E+ ++ +Q+ L ++Y+ L S QLQ+ Q+ + E+K + ++Q
Sbjct: 1499 LAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQE 1558
Query: 1552 CHQQLEDLCSWVGQAERALAGHQGRTTQQDLSA-LQKNQSDLKDLQDDIQNRATSFATVV 1610
++L+ +C + Q E L GHQ D + L+K QS ++LQ D+Q A + A VV
Sbjct: 1559 YKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVV 1618
Query: 1611 KDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETE 1670
K+ E F++EN KLS + + +KL++AK + E L + ++KEL++ VT+A+++ETE
Sbjct: 1619 KNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETE 1678
Query: 1671 KSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG---------- 1720
K A K+L E+K KI+ LLDW+++V + T + + +G ++G
Sbjct: 1679 KVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEED 1738
Query: 1721 -----ALDT-TDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHG 1774
L+T DG +G Q E L++Q + +KA+H++++SQ Q I+ATQSAQ L++ G
Sbjct: 1739 EVNGNLLETDVDGQVGTTQ--ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQG 1796
Query: 1775 HNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERS 1834
L+PEE++ LQ+ + ELK Y T+LA+SE ++K +LQ+EL+KF D+ EFE WL++S
Sbjct: 1797 QYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQS 1856
Query: 1835 EKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE--- 1891
E+ELEN+ G L + LKRQ SFSEDVISHKGDLR++TISG +VL+ S +
Sbjct: 1857 EQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDG 1916
Query: 1892 GK-EPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950
GK + S V+ KL AT+R+ +L+SKC LG++L L+ +Y +++++ L A +QA
Sbjct: 1917 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQA 1976
Query: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010
CEA K LS+ +A DP LQ QL TK LQ +++ QV VEKL+K A +++ G P
Sbjct: 1977 CEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLP 2036
Query: 2011 DHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG 2070
+Q+T D I+ ++ LS S+ ER+ LQ + +S SVQ+ L+ +L +G VE +L+
Sbjct: 2037 AKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKE 2096
Query: 2071 KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAE 2130
+ L+S +Q+ ++ N+ L+QDIA ++SS+ A E V +FMET D +TA+ LQ K+ +
Sbjct: 2097 QGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKD 2156
Query: 2131 VSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHF 2190
+S RF + + +E + +++L + E+FE+LS KLQ F+E K++ L + P +D+T
Sbjct: 2157 LSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2216
Query: 2191 FQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE 2250
Q +QE E + +++L+ L L+ E+SS G D ++ NL K F E++ T+KE
Sbjct: 2217 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2276
Query: 2251 REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWA 2310
+++ +SCQEQLD F+ LV++ + W+KET +P + S A++L K +E K L + W+
Sbjct: 2277 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWS 2336
Query: 2311 SKGTLVEEINCKGTSLENLIMEITAPD---SQGKTGSILPSVGSSVGSVNGYHTCKDLTE 2367
K ++++N G SL NLI +T P + K+G + + + + + K LT
Sbjct: 2337 LKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTS 2396
Query: 2368 IQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAM 2427
I+ DM+D++ YE LG +L ++ L L+++++ +E+++++QWL+ +
Sbjct: 2397 IKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQT 2456
Query: 2428 SSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL 2487
+PT TE VK Q E NK+F AEL+QN K+Q++K+ L LL P++ EA WK++ E+
Sbjct: 2457 PAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI 2516
Query: 2488 NSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLN 2547
+S+W+ ++T+ RQ++LEES+++L FQ E+QL+ WL+EKELM+ VLGPLSIDPNMLN
Sbjct: 2517 DSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN 2576
Query: 2548 AQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTD 2607
Q+QQVQ +L+EF R+ Q+EQL A QGIL+ PG+ V+++L ++ QKW LT
Sbjct: 2577 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTG 2636
Query: 2608 KLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEI 2667
+L+ R IDQAIVKSTQYQ LL+ LS+K+ + +LS A+ST P+A+ QQLE ++
Sbjct: 2637 QLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM 2696
Query: 2668 RSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQ 2727
+ +++Q ++K AQ LC++LS L+ E+YLK EL ++LE + + +E A + + LQ
Sbjct: 2697 KQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQ 2756
Query: 2728 AALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGS 2787
+A AS+ QFQQM + + WLD K+ +Q K+ PISAKL+ L+S ++++++F K+L S
Sbjct: 2757 SACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2816
Query: 2788 YEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQ 2847
YE +AEGE+LLL G EK LQ QL +K +W+ +K+ +R+++LK+ ++KA KY+
Sbjct: 2817 YEKTIAEGENLLLKTQ-GSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYK 2875
Query: 2848 WHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADIL 2907
VE L PWI+ C+ + E++ LDP + E+S+ + K++ E+++ ++E+LN+ A+ L
Sbjct: 2876 EQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSL 2935
Query: 2908 INSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGA 2967
++ E D++ + DE + Q +D VTE+L +K LE MTQ+ +EFQE K +++++ A
Sbjct: 2936 LSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCA 2995
Query: 2968 KHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQL 3027
K QL+I D+LGSQA SNK L L+ QQ+ LQAL+ QVD + Q LV +A D S +
Sbjct: 2996 KEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDV 3055
Query: 3028 LHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIG 3087
L Q E QE + Q+V+ C +E KL+GIG F +REMFSQ A+ DDELD M +G
Sbjct: 3056 LLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVG 3115
Query: 3088 RDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLE-EEGTLDLLGLKRELEALNKQ 3146
RD ++LQ Q E ++ FL K+ L + + C+ ML EE + DL+G+KR+LEAL+KQ
Sbjct: 3116 RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQ 3175
Query: 3147 CGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQL 3206
C KL +R +AR+EQ+E T+ R+E+FY KLK + AEE E Q VG E E INQQL
Sbjct: 3176 CNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQL 3235
Query: 3207 ADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVA 3266
FK+FQKE+++PLQ K Q VN LGQGLIQSA K QGLEHD++++NARW TLNKKVA
Sbjct: 3236 NMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA 3295
Query: 3267 QRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRL 3326
QR AQLQEALLHCG+FQDALE LLSW+ DTEEL+ANQKPPSAE+KVVKAQIQEQKLLQRL
Sbjct: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
Query: 3327 LDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILV 3386
LDDRK+TV++++ EG +IA +AE AD+ KI QL L+SRW LL+KA R +QLE I V
Sbjct: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISV 3415
Query: 3387 LAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQA 3446
+A+QFHET EP++++L+ EK+L N EP+GTQ +K+++QI +HKALE+DI NH +HQA
Sbjct: 3416 VAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQA 3475
Query: 3447 VKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVE 3506
V IGQSL L+S ++ ++ K+D Q Y EIQ++ ++ LL QAL NA++FGEDEVE
Sbjct: 3476 VSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVE 3535
Query: 3507 VLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQT 3566
++NWL EV DKLS + V+D+ + L +Q ++ L E+I+ RK+NVDQA+ NG LLKQT
Sbjct: 3536 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3595
Query: 3567 TGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEE 3626
TG+EVL+IQ+KL+ IK RY DIT S+ +TLEQA QLA + ST+EEL WL +VE E
Sbjct: 3596 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3655
Query: 3627 LATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKL 3686
L + Q GE+ Q Q R KELKKE ++ +LD++NEVS ALLELVPWRAREGL+K+
Sbjct: 3656 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3715
Query: 3687 VSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ 3746
V++ NE+Y+LVSDTI Q+V+EIDAAI RSQQ++QAADAEL+W+ ET++KLM+LG IRLEQ
Sbjct: 3716 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3775
Query: 3747 DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI 3806
DQT+AQLQVQK F+++I+RHKD +D+L +I C EE+K +++K + +++ Y+ I
Sbjct: 3776 DQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTI 3835
Query: 3807 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMR 3866
+NSERY +LERAQ LVNQFWETYEEL PW+ ET+++I+QLP+PA+++E LRQQQEE R
Sbjct: 3836 CQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHR 3895
Query: 3867 QLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALD 3926
QLRE IAEHKPHIDK+ K GPQL EL+P EG ++EKY A+ +Y+QIKE+V++RA+ALD
Sbjct: 3896 QLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALD 3955
Query: 3927 EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKL 3986
EA+SQSTQ FHDKI+ +LE+LE + RLR PP I AEV+KI+E IS+NK+ +V++EKL
Sbjct: 3956 EAISQSTQ---FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKL 4012
Query: 3987 QPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLE 4046
QP +E LK+RGEE+I RS G DKD++AK +QDKLDQMVF WE+I EERE K LDV+E
Sbjct: 4013 QPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVME 4072
Query: 4047 LAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFI 4106
LAEKFW D +L+ TIKDTQD + DLE PGIDPS++KQQ EAAETI+EE DGL EEL+ +
Sbjct: 4073 LAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIV 4132
Query: 4107 RILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQA 4166
LG++LI ACGE +KP V+KSIDE+N+AW++LNK WK+R++KLE+AMQAAVQYQD LQA
Sbjct: 4133 INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4192
Query: 4167 MFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKA 4226
+FDW+D KL +M P+GTDL TVK Q+ E+K+FK E YQQQIEME+LNHQ EL+LKK
Sbjct: 4193 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 4252
Query: 4227 TDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEE 4286
T+E+D+ +++PL ELK +W++L E+I +RQHKLEGALLALGQFQHAL+EL++WLTHTE
Sbjct: 4253 TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4312
Query: 4287 LLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRS 4346
LL Q+P+ GDPK IE+ELAKHHVL+NDVLAHQ+TVE VNKAGN+L+ESSAG++AS+L++
Sbjct: 4313 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4372
Query: 4347 RLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGL 4406
+LE +NQ W++VL+KTE+R+QQL L+QA+GFH EIED LT E L ASKP GGL
Sbjct: 4373 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4432
Query: 4407 PETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWH 4466
PETA+EQL+ HME+ + +AKEETY L+ KG+ M L+R + + +Q + L++KW
Sbjct: 4433 PETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM-LARCPKSAETNIDQDINNLKEKWE 4491
Query: 4467 VVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEE 4526
V +K+ ERK+KLEEALNLA EF NSLQ+FINWLT AEQ+LN+AS PSLIL+TVL QI+E
Sbjct: 4492 SVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDE 4551
Query: 4527 HKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGR 4586
HKVFANEVN+HR+QIIELD+TG LK+ SQKQDVVLIKNLL+SVQSRWEKVVQR +ERGR
Sbjct: 4552 HKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR 4611
Query: 4587 SLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGK 4646
SLDDARKRAKQFHEAW KL++WLE++E LDSELEI+NDPDKIK QL++HKEFQK+LG K
Sbjct: 4612 SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAK 4671
Query: 4647 QPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSG 4706
VYDTT RTGR+LKEKT L +D+ KLD+ L E+RDKWDT+CGKSVERQ+KLEEALLFSG
Sbjct: 4672 HSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSG 4731
Query: 4707 QFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRS 4766
QF DALQAL+DWLY+VEPQLAEDQPVHGD+DLVMNL+D HK FQKELGKRT +VQ LKRS
Sbjct: 4732 QFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4791
Query: 4767 GRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEW 4826
RELIE SRDD++WVK Q+QELSTRW+TVC LS+SKQ+RLE AL+QAE F VH LLEW
Sbjct: 4792 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4851
Query: 4827 LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDC 4886
L+EAEQTLRF G LPDD +AL++LID HKEFMKK+EEKR ++N A MG+ +LA+CHPD
Sbjct: 4852 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDS 4911
Query: 4887 ITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQR 4946
ITTIKHWITIIRARFEEVL WAKQHQQRL +AL+ L+A ELLE LLAW+QWAETTL +
Sbjct: 4912 ITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDK 4971
Query: 4947 DQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEP----THAPFIEKS 5002
D+E IPQ I+ VKALIAEHQTFMEEMTRKQPDVD+VTKTYKR+ +P +H P ++K
Sbjct: 4972 DKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKG 5031
Query: 5003 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5062
R+ GRK + P +Q E KNPR+N L ++WQQVWLLALER+RKLNDALDRLEEL
Sbjct: 5032 RA-GRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEEL 5090
Query: 5063 KEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKL 5122
+EFANFDFD+WRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGIL+SKFPT++L
Sbjct: 5091 REFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRL 5150
Query: 5123 EMTAVADIFDRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQ 5182
EM+AVADIFDRDGDGYIDYYEFVAALHPNKDAY+P TDADKIEDEVTRQVA+CKCAKRFQ
Sbjct: 5151 EMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQ 5210
Query: 5183 VEQIGENKYR------FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRT 5236
VEQIG+NKYR FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRA+GRT
Sbjct: 5211 VEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRT 5270
Query: 5237 NIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPAT 5296
N+ELREKFIL +GASQGM FR RGRRS+PSSR ASP RS+S +SQ+ + + P PAT
Sbjct: 5271 NMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAAS--PQVPAT 5328
Query: 5297 -----------------------------------PASGTKVIPSSGSKLKRPTPTFHSS 5321
P + P GSKL+ P + S
Sbjct: 5329 TTPKILHPLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLR--LPGYLSG 5386
Query: 5322 RTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLE 5381
+ +G+ S + A+ +T AD KK+ SRPGSRAGS+AGSRASSRRGSDASDFD+ E
Sbjct: 5387 KGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISE 5446
Query: 5382 TQSACSDTS---ESSAAGGQGNSRRGLNKPSKIPTMSKKT 5418
QS CSD ++ + SR KPSKIPT +K+
Sbjct: 5447 IQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKS 5486
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 5303 bits (13756), Expect = 0.0
Identities = 2726/5133 (53%), Positives = 3708/5133 (72%), Gaps = 167/5133 (3%)
Query: 425 RLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLI 484
RLE+L QIAN++Q ++ CE+KL LA N LQ+D+ LESG Q E+++ YI ECE L+
Sbjct: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
Query: 485 RQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLEC--------------TNLYRKG 530
RQ +D+QIL D YYQ ++L RV +L+DE++ LR EC T L G
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
Query: 531 HFTSL-----ELVPPSTLT------TTHLKAEPLTKATHSSSTS---------------- 563
SL + + PS + T L + +T S TS
Sbjct: 176 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
Query: 564 ---------------------WFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMK 602
RKP+ ++ L+ + +E+E N++FV +LL+WV+EMQ++
Sbjct: 236 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
Query: 603 LERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLE 662
L+R EWG+DLPSVE LE +++H ++EE SS+KEA++ E +M+ +YAE L +LE
Sbjct: 296 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
Query: 663 TQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYF 722
+QY KL TS + RHL +LH FVSRAT ELIWLNEKEEEE+AYDWS+ N+NI+ K++Y
Sbjct: 356 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
Query: 723 SELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHV 782
+EL EL++K++ +S+Q+ AE L LENHPA+ T+EAY AA+Q+Q W+ QLC CVEQH+
Sbjct: 416 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
Query: 783 KENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSK 842
KENTAYF+FF+DA+E +LRNL+D+I+RKYSCD ++S+ +LEDL+Q+SM+EKE+L+Q K
Sbjct: 476 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
Query: 843 SSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTK 902
S++A+L+G++KTI+QLKPR+ D LK +I +KA+CDYRQIEITI K+DECVL +NS R K
Sbjct: 536 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
Query: 903 WKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNY 962
WKVISPTGNEAMVPSVCF +PPPNK+A+++A+R+EQ YQ V+ LWH+ H+N KS++SW+Y
Sbjct: 596 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
Query: 963 LRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEV 1022
L ++D ++ N+ +++ PGE Q++ NLQ+ +EDFL+DS++S +FS +D +LE+EV
Sbjct: 656 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
Query: 1023 EACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRD 1082
CK +Q L+KS E E++EE+V +YISE++NIRLRLE E R++++I++ +RD
Sbjct: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT----PLERD 771
Query: 1083 AWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKM 1142
++ RI EQE +++L++L+ DL ++ KC+ F Q+ +SSSVPTLRSELN++++ M
Sbjct: 772 DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM 831
Query: 1143 DHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRH 1202
+ VY +S+ Y++KLKTV++++++ Q AE LVK YE KL +EE V+AD + +E STL+
Sbjct: 832 NQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 891
Query: 1203 WLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQ 1262
W S+V +K VF L++E+ KAK ++++M + ER+LD + ++EK QL ERW V Q
Sbjct: 892 WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 951
Query: 1263 LEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTAL 1322
++ R +LE I + L YR + L WI++ Q ++ Q E+S+ L+ QL+QQ L
Sbjct: 952 IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1011
Query: 1323 FAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAIT 1382
+EIE Q+K+D+CQK+++QYS VKDYELQ MTY+A V+SQQKSP KRRRM SS+D I
Sbjct: 1012 VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII 1071
Query: 1383 QEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLA 1442
QEFMDLRTRYTALVTL TQ++K+ D+L+RLEEEEK +EEEK+EHVEK KEL WVS ++
Sbjct: 1072 QEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS 1131
Query: 1443 RNTQGKATSSETKESTDIEKA----ILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHK 1498
+ + D EKA +Q++ SEE++TKKEQ+SEA++T Q+FLAKHG K
Sbjct: 1132 KTLK------------DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDK 1179
Query: 1499 LSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLED 1558
++++E+ ++ +Q+ L ++Y+ L S QLQ+ Q+ + E+K + ++Q ++L+
Sbjct: 1180 MTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQG 1239
Query: 1559 LCSWVGQAERALAGHQGRTTQQDLSA-LQKNQSDLKDLQDDIQNRATSFATVVKDIEGFM 1617
+C + Q E L GHQ D + L+K QS ++LQ D+Q A + A VVK+ E F+
Sbjct: 1240 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1299
Query: 1618 EENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKE 1677
+EN KLS + + +KL++AK + E L + ++KEL++ VT+A+++ETEK A K+
Sbjct: 1300 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1359
Query: 1678 LAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG---------------AL 1722
L E+K KI+ LLDW+++V + T + + +G ++G L
Sbjct: 1360 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLL 1419
Query: 1723 DT-TDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEE 1781
+T DG +G Q E L++Q + +KA+H++++SQ Q I+ATQSAQ L++ G L+PEE
Sbjct: 1420 ETDVDGQVGTTQ--ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEE 1477
Query: 1782 QQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENM 1841
++ LQ+ + ELK Y T+LA+SE ++K +LQ+EL+KF D+ EFE WL++SE+ELEN+
Sbjct: 1478 KEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENL 1537
Query: 1842 HKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE---GK-EPSE 1897
G L + LKRQ SFSEDVISHKGDLR++TISG +VL+ S + GK + S
Sbjct: 1538 EAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSA 1597
Query: 1898 IGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEK 1957
V+ KL AT+R+ +L+SKC LG++L L+ +Y +++++ L A +QACEA K
Sbjct: 1598 THREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK 1657
Query: 1958 LLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQE 2017
LS+ +A DP LQ QL TK LQ +++ QV VEKL+K A +++ G P +Q+
Sbjct: 1658 HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQK 1717
Query: 2018 TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLS 2077
T D I+ ++ LS S+ ER+ LQ + +S SVQ+ L+ +L +G VE +L+ + L+
Sbjct: 1718 TLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLN 1777
Query: 2078 SGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQ 2137
S +Q+ ++ N+ L+QDIA ++SS+ A E V +FMET D +TA+ LQ K+ ++S RF +
Sbjct: 1778 STALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSE 1837
Query: 2138 LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQEL 2197
+ +E + +++L + E+FE+LS KLQ F+E K++ L + P +D+T Q +QE
Sbjct: 1838 ASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQES 1897
Query: 2198 NLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASS 2257
E + +++L+ L L+ E+SS G D ++ NL K F E++ T+KE+++ +S
Sbjct: 1898 TSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 1957
Query: 2258 CQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVE 2317
CQEQLD F+ LV++ + W+KET +P + S A++L K +E K L + W+ K ++
Sbjct: 1958 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2017
Query: 2318 EINCKGTSLENLIMEITAPD---SQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSD 2374
++N G SL NLI +T P + K+G + + + + + K LT I+ DM+D
Sbjct: 2018 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTD 2077
Query: 2375 VNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTE 2434
++ YE LG +L ++ L L+++++ +E+++++QWL+ + +PT TE
Sbjct: 2078 ISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTE 2137
Query: 2435 TVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERA 2494
VK Q E NK+F AEL+QN K+Q++K+ L LL P++ EA WK++ E++S+W+
Sbjct: 2138 AVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQEL 2197
Query: 2495 TEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQ 2554
++T+ RQ++LEES+++L FQ E+QL+ WL+EKELM+ VLGPLSIDPNMLN Q+QQVQ
Sbjct: 2198 NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2257
Query: 2555 FMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSS 2614
+L+EF R+ Q+EQL A QGIL+ PG+ V+++L ++ QKW LT +L+ R
Sbjct: 2258 ILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCD 2317
Query: 2615 QIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQL 2674
IDQAIVKSTQYQ LL+ LS+K+ + +LS A+ST P+A+ QQLE +++ +++Q
Sbjct: 2318 WIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQE 2377
Query: 2675 DHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQ 2734
++K AQ LC++LS L+ E+YLK EL ++LE + + +E A + + LQ+A AS+
Sbjct: 2378 KKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSH 2437
Query: 2735 QFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAE 2794
QFQQM + + WLD K+ +Q K+ PISAKL+ L+S ++++++F K+L S YE +AE
Sbjct: 2438 QFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE 2497
Query: 2795 GESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLV 2854
GE+LLL G EK LQ QL +K +W+ +K+ +R+++LK+ ++KA KY+ VE L
Sbjct: 2498 GENLLLKTQ-GSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLW 2556
Query: 2855 PWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD 2914
PWI+ C+ + E++ LDP + E+S+ + K++ E+++ ++E+LN+ A+ L++ E D
Sbjct: 2557 PWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2616
Query: 2915 EDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF 2974
++ + DE + Q +D VTE+L +K LE MTQ+ +EFQE K +++++ AK QL+I
Sbjct: 2617 KEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH 2676
Query: 2975 DALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA 3034
D+LGSQA SNK L L+ QQ+ LQAL+ QVD + Q LV +A D S +L Q E
Sbjct: 2677 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETI 2736
Query: 3035 QQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQ 3094
QE + Q+V+ C +E KL+GIG F +REMFSQ A+ DDELD M +GRD ++LQ
Sbjct: 2737 AQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQ 2796
Query: 3095 SQIEDVRLFLNKIHVLKLDIEASEAECRHMLE-EEGTLDLLGLKRELEALNKQCGKLTER 3153
Q E ++ FL K+ L + + C+ ML EE + DL+G+KR+LEAL+KQC KL +R
Sbjct: 2797 KQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDR 2856
Query: 3154 GKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQ 3213
+AR+EQ+E T+ R+E+FY KLK + AEE E Q VG E E INQQL FK+FQ
Sbjct: 2857 AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQ 2916
Query: 3214 KEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQ 3273
KE+++PLQ K Q VN LGQGLIQSA K QGLEHD++++NARW TLNKKVAQR AQLQ
Sbjct: 2917 KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQ 2976
Query: 3274 EALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT 3333
EALLHCG+FQDALE LLSW+ DTEEL+ANQKPPSAE+KVVKAQIQEQKLLQRLLDDRK+T
Sbjct: 2977 EALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKST 3036
Query: 3334 VDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHE 3393
V++++ EG +IA +AE AD+ KI QL L+SRW LL+KA R +QLE I V+A+QFHE
Sbjct: 3037 VEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHE 3096
Query: 3394 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3453
T EP++++L+ EK+L N EP+GTQ +K+++QI +HKALE+DI NH +HQAV IGQSL
Sbjct: 3097 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL 3156
Query: 3454 SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAE 3513
L+S ++ ++ K+D Q Y EIQ++ ++ LL QAL NA++FGEDEVE++NWL E
Sbjct: 3157 KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNE 3216
Query: 3514 VEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLL 3573
V DKLS + V+D+ + L +Q ++ L E+I+ RK+NVDQA+ NG LLKQTTG+EVL+
Sbjct: 3217 VHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLI 3276
Query: 3574 IQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQ 3633
IQ+KL+ IK RY DIT S+ +TLEQA QLA + ST+EEL WL +VE EL + Q
Sbjct: 3277 IQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQ 3336
Query: 3634 SPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQ 3693
GE+ Q Q R KELKKE ++ +LD++NEVS ALLELVPWRAREGL+K+V++ NE+
Sbjct: 3337 VLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNER 3396
Query: 3694 YKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQL 3753
Y+LVSDTI Q+V+EIDAAI RSQQ++QAADAEL+W+ ET++KLM+LG IRLEQDQT+AQL
Sbjct: 3397 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3456
Query: 3754 QVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSER 3813
QVQK F+++I+RHKD +D+L +I C EE+K +++K + +++ Y+ I +NSER
Sbjct: 3457 QVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSER 3516
Query: 3814 YARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIA 3873
Y +LERAQ LVNQFWETYEEL PW+ ET+++I+QLP+PA+++E LRQQQEE RQLRE IA
Sbjct: 3517 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 3576
Query: 3874 EHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQST 3933
EHKPHIDK+ K GPQL EL+P EG ++EKY A+ +Y+QIKE+V++RA+ALDEA+SQST
Sbjct: 3577 EHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST 3636
Query: 3934 QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEAL 3993
Q FHDKI+ +LE+LE + RLR PP I AEV+KI+E IS+NK+ +V++EKLQP +E L
Sbjct: 3637 Q---FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 3693
Query: 3994 KRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWY 4053
K+RGEE+I RS G DKD++AK +QDKLDQMVF WE+I EERE K LDV+ELAEKFW
Sbjct: 3694 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 3753
Query: 4054 DMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADL 4113
D +L+ TIKDTQD + DLE PGIDPS++KQQ EAAETI+EE DGL EEL+ + LG++L
Sbjct: 3754 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSEL 3813
Query: 4114 IFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDN 4173
I ACGE +KP V+KSIDE+N+AW++LNK WK+R++KLE+AMQAAVQYQD LQA+FDW+D
Sbjct: 3814 IAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDI 3873
Query: 4174 TVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRD 4233
KL +M P+GTDL TVK Q+ E+K+FK E YQQQIEME+LNHQ EL+LKK T+E+D+
Sbjct: 3874 AGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKH 3933
Query: 4234 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4293
+++PL ELK +W++L E+I +RQHKLEGALLALGQFQHAL+EL++WLTHTE LL Q+P
Sbjct: 3934 TVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 3993
Query: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4353
+ GDPK IE+ELAKHHVL+NDVLAHQ+TVE VNKAGN+L+ESSAG++AS+L+++LE +NQ
Sbjct: 3994 VGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQ 4053
Query: 4354 CWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQ 4413
W++VL+KTE+R+QQL L+QA+GFH EIED LT E L ASKP GGLPETA+EQ
Sbjct: 4054 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4113
Query: 4414 LDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4473
L+ HME+ + +AKEETY L+ KG+ M L+R + + +Q + L++KW V +K+
Sbjct: 4114 LNVHMEVCAAFEAKEETYKSLMQKGQQM-LARCPKSAETNIDQDINNLKEKWESVETKLN 4172
Query: 4474 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANE 4533
ERK+KLEEALNLA EF NSLQ+FINWLT AEQ+LN+AS PSLIL+TVL QI+EHKVFANE
Sbjct: 4173 ERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANE 4232
Query: 4534 VNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARK 4593
VN+HR+QIIELD+TG LK+ SQKQDVVLIKNLL+SVQSRWEKVVQR +ERGRSLDDARK
Sbjct: 4233 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4292
Query: 4594 RAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTT 4653
RAKQFHEAW KL++WLE++E LDSELEI+NDPDKIK QL++HKEFQK+LG K VYDTT
Sbjct: 4293 RAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTT 4352
Query: 4654 IRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQ 4713
RTGR+LKEKT L +D+ KLD+ L E+RDKWDT+CGKSVERQ+KLEEALLFSGQF DALQ
Sbjct: 4353 NRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQ 4412
Query: 4714 ALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN 4773
AL+DWLY+VEPQLAEDQPVHGD+DLVMNL+D HK FQKELGKRT +VQ LKRS RELIE
Sbjct: 4413 ALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG 4472
Query: 4774 SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQT 4833
SRDD++WVK Q+QELSTRW+TVC LS+SKQ+RLE AL+QAE F VH LLEWL+EAEQT
Sbjct: 4473 SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQT 4532
Query: 4834 LRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 4893
LRF G LPDD +AL++LID HKEFMKK+EEKR ++N A MG+ +LA+CHPD ITTIKHW
Sbjct: 4533 LRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHW 4592
Query: 4894 ITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQ 4953
ITIIRARFEEVL WAKQHQQRL +AL+ L+A ELLE LLAW+QWAETTL +D+E IPQ
Sbjct: 4593 ITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQ 4652
Query: 4954 NIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEP----THAPFIEKSRSGGRKS 5009
I+ VKALIAEHQTFMEEMTRKQPDVD+VTKTYKR+ +P +H P ++K R+ GRK
Sbjct: 4653 EIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRA-GRKR 4711
Query: 5010 LSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFD 5069
+ P +Q E KNPR+N L ++WQQVWLLALER+RKLNDALDRLEEL+EFANFD
Sbjct: 4712 FPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFD 4771
Query: 5070 FDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVAD 5129
FD+WRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGIL+SKFPT++LEM+AVAD
Sbjct: 4772 FDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVAD 4831
Query: 5130 IFDRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGEN 5189
IFDRDGDGYIDYYEFVAALHPNKDAY+P TDADKIEDEVTRQVA+CKCAKRFQVEQIG+N
Sbjct: 4832 IFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDN 4891
Query: 5190 KYR------FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREK 5243
KYR FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRA+GRTN+ELREK
Sbjct: 4892 KYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREK 4951
Query: 5244 FILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPAT------- 5296
FIL +GASQGM FR RGRRS+PSSR ASP RS+S +SQ+ + + P PAT
Sbjct: 4952 FILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAAS--PQVPATTTPKILH 5009
Query: 5297 ----------------------------PASGTKVIPSSGSKLKRPTPTFHSSRTSLAGD 5328
P + P GSKL+ P + S + +G+
Sbjct: 5010 PLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLR--LPGYLSGKGFHSGE 5067
Query: 5329 TSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSD 5388
S + A+ +T AD KK+ SRPGSRAGS+AGSRASSRRGSDASDFD+ E QS CSD
Sbjct: 5068 DSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSD 5127
Query: 5389 TS---ESSAAGGQGNSRRGLNKPSKIPTMSKKT 5418
++ + SR KPSKIPT +K+
Sbjct: 5128 VETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKS 5160
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 1421 bits (3679), Expect = 0.0
Identities = 947/2837 (33%), Positives = 1513/2837 (53%), Gaps = 251/2837 (8%)
Query: 31 SGSLSPCPPGDTLPWNLPLHEQKKRK-----SQDSVLDPAERAVVRVADERDRVQKKTFT 85
+GS PGDTLPWNL ++ +R S SVLDPAERAV+R+ADERDRVQKKTFT
Sbjct: 17 NGSSGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAVIRIADERDRVQKKTFT 76
Query: 86 KWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDF 145
KWVNKHL+K ++HI+DLYEDLRDGHNLISLLEVLSG LPREKGRMRFH+LQNVQIALD+
Sbjct: 77 KWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDY 136
Query: 146 LKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGDMSAKEKLLLWTQ 205
L+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI +SG+S DM+AKEKLLLW+Q
Sbjct: 137 LRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQ 196
Query: 206 KVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAER- 264
++ GY G++C NF+S W DG++FNA+IHR++P L+DM +V Q+N ENL+QAF VAER
Sbjct: 197 RMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERD 256
Query: 265 LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVD 324
LGVTRLLD EDVDVP PDEKS+ITYVSS+YDA P+VP+ +G+ A E+ RWQEY+ V
Sbjct: 257 LGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVL 316
Query: 325 SLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLEVW 384
L+ W++ HT ++ FP + E++ L++Q++ FKE E+ AKE +K R + +Y+ LE
Sbjct: 317 LLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGA 376
Query: 385 IEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCE 444
++ G++K+P GYHP DVE+EWGKL + +LEREK LR ERLE L +I K+Q A CE
Sbjct: 377 VQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCE 436
Query: 445 EKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEE 504
E+L A LQ+D L +G+ Q +V + + + +IR L D+Q L+D + Q E+
Sbjct: 437 EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 496
Query: 505 LAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSW 564
+ RV RL + LV +R E + G A P T+ + S
Sbjct: 497 MYRRVYRLHERLVAIRTEYNLRLKAG------------------VAAPATQVAQVTLQSV 538
Query: 565 FRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQH 624
R+P EL ++ LR++ +LL+WVEE Q +++ AEWG DLPSVE QL + +
Sbjct: 539 QRRP----EL-------EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRG 587
Query: 625 IHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHK 684
+H S+EE + ++ AR EG++S +Y + LG+L+ QY KL +S R+R L+SLH
Sbjct: 588 LHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 647
Query: 685 FVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAE 744
FV+ AT EL+WLNEKEEEE+ +DWSD N+N++AK+ +S L ELE K+ + LQ+ +
Sbjct: 648 FVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGD 707
Query: 745 LLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRN 804
L E+HPA+ TVE++ AA+Q+Q WM QLC C+E H+KEN AYFQFFSD RE E L+
Sbjct: 708 RLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQK 767
Query: 805 LQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPD 864
LQ++++RKYSCD + +++RLEDLLQD+ DEKEQL + K ++ L R+K +VQLKPR P
Sbjct: 768 LQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPA 827
Query: 865 HVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPP 924
H ++ + + AVCDY+Q+E+T+ K DEC L +Q + WKV+S +G+EA VPSVCFL+PP
Sbjct: 828 HPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPP 887
Query: 925 PNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPG 984
PN++A E +R+E +Q ++ LWHQLHV+ KSL++W LR+D+ L+++W+L R+ P
Sbjct: 888 PNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPE 947
Query: 985 ECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEET 1044
E Q + +L+ HY+ FL+DS+D+ F DRL E E +C +Q L++S+E +EE+
Sbjct: 948 EQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 1007
Query: 1045 VAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQL 1104
+ ISELK+IRL+LE E R V R++ D++ ++ A RIAEQ+ Q +++ L
Sbjct: 1008 RCQRCISELKDIRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQKAQAEVEGL 1063
Query: 1105 RSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVR 1164
+ +S + + L S + PTLRSEL L + K++ V LS +YL KLKT+ +++R
Sbjct: 1064 GKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIR 1123
Query: 1165 SIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKA 1224
Q AE +++ +E +L + + V A L LEA ++L+ + + + F L +E+ A
Sbjct: 1124 GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGA 1183
Query: 1225 KVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACH 1284
+ V E++ + ER++++ER++E+ +QL ERW V+AQ ++RQ ELE + L YR
Sbjct: 1184 QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1243
Query: 1285 GTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYS 1344
L W+++ +QE ++ DS+ + EQL Q+ AL EIER+ K+++CQ+F++QY
Sbjct: 1244 DPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI 1303
Query: 1345 TIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVK 1404
+KDYELQL+TYKA +E SP K+ ++ S S+++ QE++DLRT Y+ L TLT+Q++K
Sbjct: 1304 NAIKDYELQLVTYKAQLE-PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1362
Query: 1405 YISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAI 1464
+IS+ LRR+EEEE++ E+++ E E++ E+ + L + Q ++ K + E
Sbjct: 1363 FISETLRRMEEEERLAEQQRAEERERLAEV---EAALEKQRQLAEAHAQAKAQAEREAKE 1419
Query: 1465 LEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDG 1524
L+Q+ + EE+ ++E +A +++K+ I E+L L ++
Sbjct: 1420 LQQR-MQEEVVRREEAAVDA----------------QQQKRSIQEELQQLRQSSEAEIQA 1462
Query: 1525 SANQLQQLQ-SQLAHQTEQKTLQKQQNTCHQQL----EDLCSWVGQAERALAGHQGRTTQ 1579
A Q + + S+L + E + ++ Q +Q +L + +AE A A Q R Q
Sbjct: 1463 KARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA--QKRQAQ 1520
Query: 1580 QDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQA 1639
++ L+ + +QD+ Q + + + ++ E + K R L AL E QA
Sbjct: 1521 EEAERLR------RQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQA 1572
Query: 1640 KEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSG 1699
+E E R+ Q E+E A + ET + A EL + S
Sbjct: 1573 EE------AERRLRQAEVERARQVQVALETAQRSAEAELQSKR----------ASFAEKT 1616
Query: 1700 GQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLS---QQ 1756
QL +L E ++ A L + A +A E+ +++ E + + E L Q
Sbjct: 1617 AQLERSLQ-EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1675
Query: 1757 QNFILATQSAQAFLDQHGHNL--------TPEEQQMLQQKLGELKEQYSTSLAQSEAELK 1808
+ AQA ++ EEQ + Q++L E + + LA+ A+
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1733
Query: 1809 QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISH 1868
Q + EL + + ++ E + E+EL + + E + KRQ ++
Sbjct: 1734 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-----EAAAATQKRQ-ELEAELAKV 1787
Query: 1869 KGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLN 1928
+ ++ + S + + S E K +L+ R+ L + RL +
Sbjct: 1788 RAEMEVLLASKARAEEESRSTSEKS---------KQRLEAEAGRFRELAEEAARLRA--- 1835
Query: 1929 MLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQ 1988
L + + Q A Q EA E++L++ +A+ + E + + L E +
Sbjct: 1836 --LAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAA----IGEATRLKTEAEIALKEKE 1887
Query: 1989 VPVEKLQKVARD----IMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAER-SSLLQKA 2043
E+L+++A D +E + A ++E L+ + S S ER L++
Sbjct: 1888 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKASDSELERQKGLVEDT 1943
Query: 2044 IAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLE 2103
+ Q + V+E + +L S E+ GK L G I+ ++ +++++ LE
Sbjct: 1944 LRQRRQVEEEILALKASF---EKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELE 1995
Query: 2104 ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLS 2163
A R+ AA + + E +R ++ ++E K L + E +
Sbjct: 1996 AARQ----------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2045
Query: 2164 GKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGF 2223
+ ++ E + A Q Q+ Q +E QQ+ + + L E S
Sbjct: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV--- 2102
Query: 2224 ALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI 2283
L Q + + R+ E ++ + E++A+ + Q++E +L ++ +
Sbjct: 2103 ---LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---------- 2149
Query: 2284 PPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG 2343
E + + + + E L+ + A++ E+ + + ME ++
Sbjct: 2150 ---EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE---- 2202
Query: 2344 SILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEV 2403
T + +++ +++ + L+ E+ + E LQ + E
Sbjct: 2203 ----------------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2246
Query: 2404 HKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA 2463
++ + V + L S ++ + + + + E L++ + K+++V E
Sbjct: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2306
Query: 2464 LAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLR 2523
A L V +QEA +++ EE ++ E + + Q + A+ L AE++L
Sbjct: 2307 AARLSVA---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL----KAEAELL 2359
Query: 2524 PWLMEKELMMGVLGPLSIDPNMLNAQ-KQQVQFMLKEFEARRQQHEQLNEAAQGILTGPG 2582
+KEL L D + Q ++ Q + EA RQ+ +++ A+ +
Sbjct: 2360 Q--QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417
Query: 2583 DVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQ 2642
++S + ++ +++ Q ++ E+ +KL+ R+ Q EKV V Q
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELATQ----------------EKVTLV-Q 2459
Query: 2643 RLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYL----- 2697
L +Q S ++ E +E+ + E+L E K Q +E+ + EQ L
Sbjct: 2460 TLEIQRQQSDHD--AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517
Query: 2698 --------KDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD 2749
KD L +R + LE L D + + Q Q+ QQ ++ R L
Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2577
Query: 2750 KQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKR 2809
+ + + E + ++ EE Q+ Q E++ E + L E+ +
Sbjct: 2578 SMEEARRR-----QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL------REQLQ 2626
Query: 2810 TLQNQLVELKNHWEELS 2826
L+ Q H EE++
Sbjct: 2627 LLEEQHRAALAHSEEVT 2643
Score = 131 bits (329), Expect = 2e-29
Identities = 322/1752 (18%), Positives = 693/1752 (39%), Gaps = 241/1752 (13%)
Query: 2635 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE 2694
E R QR++ Q + E + + + S + L A TL EL + +G+
Sbjct: 1041 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1100
Query: 2695 ----QYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750
+ L ++L+T++L ++G + A + + + L Q EL
Sbjct: 1101 LEQVRSLSAIYLEKLKTISLVIRGTQG-AEEVLRAHEEQLKEAQAVPATLPELEATKASL 1159
Query: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810
+ +A+ + L+ +L+ +E + L Q G +V E
Sbjct: 1160 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV----------------EVER 1203
Query: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV- 2869
+ ++ +L W+ + +T RQ L+ ++ + Y+ + L W++D + + +++
Sbjct: 1204 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1263
Query: 2870 -TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQN 2928
D + L + +A+L E+E+ +E A IN+ + E + KA + +
Sbjct: 1264 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-EP 1322
Query: 2929 MDAVTEELQAKTGSLEEMTQRLREFQESFKNIE-------KKVEGAKHQLEIFDALGSQA 2981
+ + ++ + ++GS E + Q + + + + K + ++E + L Q
Sbjct: 1323 VASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ- 1380
Query: 2982 CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV 3041
+ E+ EV ALE Q Q + A++E E+
Sbjct: 1381 ---QRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-----------------AEREAKEL 1420
Query: 3042 KQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD-ELDGMGAIGRDTDSLQSQIEDV 3100
+QR+ V E Q ++E QL + E+ + + +IE+
Sbjct: 1421 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1479
Query: 3101 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQ 3160
+I V++L +EA+E + G G + EL+AL + + + + QE+
Sbjct: 1480 -----EIRVVRLQLEATE-------RQRG-----GAEGELQALRARAEEAEAQKRQAQEE 1522
Query: 3161 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPL 3220
E +V+D ++ + + +AEA E + Q L + ++ Q +
Sbjct: 1523 AERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRL----QAEEA 1575
Query: 3221 QMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME-EINARWNTLNKKVAQRIAQLQEALLHC 3279
+ +L+Q +Q A ++ + E E+ ++ + +K AQ LQE +
Sbjct: 1576 ERRLRQAEVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1630
Query: 3280 GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT--VDML 3337
+ ++ E A+ E + AE ++ + Q++ + L+ L + +
Sbjct: 1631 AQLREEAERRAQQQAEAE-----RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397
QAE + + AE R + G+ E R EL + +Q+QL + A+Q +
Sbjct: 1686 QAEAEKQKEEAEREARRR--GKAEEQAVRQRELAEQELEKQRQLAE--GTAQQRLAAEQE 1741
Query: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKI---GQSLS 3454
+ + TE+ + + + A++Q++ +++E V +++ ++ +
Sbjct: 1742 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1801
Query: 3455 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED----------- 3503
S + +++++ R+ E+ + R AL ++A +L ED
Sbjct: 1802 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1861
Query: 3504 ----------------EVEVLNWLAEVEDKLSSVFVKD--FKQDVLHRQHADHLA-LNEE 3544
E E+ E E++ +D F++ L Q A H A + E
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1921
Query: 3545 IVNRKKNVDQAIKNGQALLKQT------TGEEVLLIQEKLDGIKTRYADITV-------T 3591
+ +K D ++ + L++ T EE+L ++ + A++ +
Sbjct: 1922 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1981
Query: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS-GGQSPTGEQIPQFQQRQKEL 3650
+ LR+ EQA A + + E RE EE + S + Q + + L
Sbjct: 1982 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2041
Query: 3651 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA 3710
K +V E R + + + S L+L A+E K + + + V + +
Sbjct: 2042 KAKVEEARRLRERAEQESARQLQL----AQEAAQKRLQAEEKAHAFA-------VQQKEQ 2090
Query: 3711 AIQRSQQYEQAADAELAWVAETKRKLMALGP---IRLEQDQTTAQLQVQKAFSIDIIRHK 3767
+Q++ Q EQ+ +L AE R+ ++ E++ ++ QV++A R K
Sbjct: 2091 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-----ERLK 2145
Query: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKT------ESLIQQYEA--ISLLNSERYAR--- 3816
S +E R++ + +K QE ++ ++Q +A + +++A
Sbjct: 2146 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205
Query: 3817 LERAQV------LVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 3870
++AQV L Q ET + + EE + L A+ A Q+ ++ +R E
Sbjct: 2206 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2265
Query: 3871 SIAEHKPHIDK-----LLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALAL 3925
+++ K I+ +L+ + EE E +++ ++A + +E R R LA
Sbjct: 2266 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA- 2324
Query: 3926 DEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEK 3985
+E ++Q + E + + E ++ + R + AE + +++ + A + +
Sbjct: 2325 EEDLAQQRALAE-----KMLKEKMQAVQEATR----LKAEAELLQQ---QKELAQEQARR 2372
Query: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045
LQ E ++ ++L +QG + L A E Q +L ++ A AE +++ ++
Sbjct: 2373 LQ---EDKEQMAQQLAEETQGFQRTLEA-ERQRQL--------EMSAEAERLKLRVAEMS 2420
Query: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105
+ D ++ + +H E +++V +T++ + + E
Sbjct: 2421 RAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEIQRQQSDHDAER 2474
Query: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER-LEKLEDAMQAAVQYQDTL 4164
+R A+L E EK ++++ + E + +E+ L++ + Q+ + +D+L
Sbjct: 2475 LREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2529
Query: 4165 QAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK 4224
+++ KL + +D++ + ++ + E +QQ +ME+ + ++
Sbjct: 2530 LQRERFIEQEKAKLEQL---------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2580
Query: 4225 KA---TDETDRDIIR--EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4279
+A E + + R E L +L+ E +A +L Q Q E+ +
Sbjct: 2581 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR------EQLQLLEEQHRA 2634
Query: 4280 WLTHTEELLDAQ 4291
L H+EE+ +Q
Sbjct: 2635 ALAHSEEVTASQ 2646
Score = 129 bits (325), Expect = 6e-29
Identities = 545/2630 (20%), Positives = 996/2630 (37%), Gaps = 398/2630 (15%)
Query: 1209 DKNSVFSVLD-EEIAKAKVVAEQ---MSRLTPERNLDLERYQEKG-----SQLQERWHRV 1259
D N V+ + E + +A VAE+ ++RL ++D+ + EK S L + RV
Sbjct: 233 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 292
Query: 1260 I-AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKPGQAEDSRVLSEQLS 1317
Q +R +EL+ + +YR L++W+ TA +E P E+ +L Q
Sbjct: 293 PDVQDGVRANELQLRWQ---EYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 349
Query: 1318 QQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSS 1377
+ + E+ + ++ + Q V+ +L++ PG
Sbjct: 350 KFKEM--ELPAKEADKNRSKGIYQSLEGAVQAGQLKV------------PPGYHP----- 390
Query: 1378 SDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGW 1437
+D+ + L + K + RLE +++V + + E +E L
Sbjct: 391 --------LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME-AGLCEEQLNQ 441
Query: 1438 VSTLARN-----TQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFL 1492
L ++ GK + D++KA ++L ++ T K+
Sbjct: 442 ADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD------------- 488
Query: 1493 AKH--GHKLSEKEKKQISEQLNALNKAYH-DLCDGSANQLQQLQSQLAHQTEQKTLQKQQ 1549
+H G ++ + + + E+L A+ Y+ L G A Q+ +Q+ Q+ Q+ + +
Sbjct: 489 GRHPQGEQMYRRVYR-LHERLVAIRTEYNLRLKAGVAAPATQV-AQVTLQSVQRRPELED 546
Query: 1550 NTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATV 1609
+T + L+DL +WV + + + G + DL +++ + L I+
Sbjct: 547 STL-RYLQDLLAWVEENQHRVDGAEWGV---DLPSVEAQLGSHRGLHQSIEEFRAKIERA 602
Query: 1610 VKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
D + +LSP A R+ L + QY L ++ + LE +
Sbjct: 603 RSD--------EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV----- 649
Query: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729
+ A KEL +K + VG TN+ ++ A + + L
Sbjct: 650 --AAATKELMWLNEKEEE------EVGFDWSDRNTNMTAKKESYSALMRELELKEKK-IK 700
Query: 1730 GVNQAPEKL---DKQCEMMKARHQELLSQQQNFIL-------ATQSAQAFLDQHGHNLTP 1779
+ A ++L D Q L Q +++L A A Q ++
Sbjct: 701 ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 760
Query: 1780 EEQQMLQQKLGE-LKEQYSTSLAQSEAELKQV-QTLQDELQKFLQDHKEFESWLERSEK- 1836
E Q+ QKL E L+ +YS + + L+ + Q QDE ++ L ++K S L + K
Sbjct: 761 AEGQL--QKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ-LNEYKGHLSGLAKRAKA 817
Query: 1837 --ELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQ----KVLDMENSFK 1890
+L+ H LP LL +V HKGD + Q KVL S
Sbjct: 818 VVQLKPRHPAHPMRGRLP-LLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-- 874
Query: 1891 EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950
E PS + LV ++A E T RL + L+ +HQ SL AW Q+
Sbjct: 875 EAAVPS-VCFLVPPPNQEAQEAVT-------RLEAQHQALVTLWHQLHVDMKSLLAW-QS 925
Query: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010
+V+ + S ++A+ T K ++ A H + + Q RD + G
Sbjct: 926 LRRDVQLIRSWSLAT--------FRTLKPEEQRQALHSLELH-YQAFLRDSQDAGGFGPE 976
Query: 2011 DHRHVQETTDSILSHFQSLSYSL---AERSSLLQKAIAQSQSVQESLESL-LQSIGEVEQ 2066
D + S H+Q L SL A+ S Q+ I++ + ++ LE+ +++ +
Sbjct: 977 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1036
Query: 2067 NLEGKQVSSLSSGVI--QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2124
L+ + + + Q+A A L + +AR L A E V E S A L
Sbjct: 1037 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR----LSAEAEKVLALPEP--SPAAPTL 1090
Query: 2125 QGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2181
+ +L + EQ L EK ++ ++ + E + ++ ++ + A+
Sbjct: 1091 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT-- 1148
Query: 2182 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---------DLCQHQD 2232
P+ + T +++L + E QQ D L + G L ++ + ++
Sbjct: 1149 LPELEATK--ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1206
Query: 2233 RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSA 2292
RV L + + + R+++ QL +R+ WL++ + A
Sbjct: 1207 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1266
Query: 2293 --KELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME-----ITAPDSQGKTGSI 2345
+ + +Q+ ++LL++ G VEE N I + +T S
Sbjct: 1267 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1326
Query: 2346 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2405
GS + DL +++ + +Y K R E + + + +
Sbjct: 1327 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1386
Query: 2406 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2465
E + ++ K+ L A + K + + + E+ + Q+ K ++
Sbjct: 1387 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446
Query: 2466 GLLVTYPNSQEAENWKKIQE----------------------------------ELNSRW 2491
L S EAE K ++ EL +
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1506
Query: 2492 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 2551
RA E A++RQ +E A L ESQ R E EL V A +
Sbjct: 1507 ARAEEAE-AQKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQA 1564
Query: 2552 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ--VQKELQSINQKWVELTDKL 2609
+ L+ EA R+ + E A+ + V+L T+Q + ELQS + E T +L
Sbjct: 1565 LEELRLQAEEAERRLRQAEVERARQV-----QVALETAQRSAEAELQSKRASFAEKTAQL 1619
Query: 2610 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRS 2669
RS Q + V L++ +E+ RA Q + ++ + E + QL+ +R
Sbjct: 1620 E-RSLQEEHVAVAQ------LREEAER-RAQQQAEAERAREEAERELERWQLKANEALRL 1671
Query: 2670 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK-RLETVALPLQGLEDLAADRINRLQA 2728
L+ EV + ++L + E+ ++ ++ + E A+ + L + ++ +L
Sbjct: 1672 RLQA--EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1729
Query: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQL----QENEEFQKSLNQH 2784
A Q+ + +R + +Q +Q + + +L RLQ + Q+ +E + L +
Sbjct: 1730 GTAQ-QRLAAEQELIRLRAETEQGEQQRQL-LEEELARLQREAAAATQKRQELEAELAKV 1787
Query: 2785 SGSYEVIVA-----EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK-----KTADRQS 2834
EV++A E ES S + K+ L+ + + EE ++ + A RQ
Sbjct: 1788 RAEMEVLLASKARAEEESRSTSE---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1844
Query: 2835 RLKD---CMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVE 2891
+L + Q+A+ + E L E + K +E + L + E+ LR A +
Sbjct: 1845 QLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQ 1903
Query: 2892 KRRSLLEILNSAADI---LINSSEADEDGIRDEKAGINQNMDA---VTEELQAKTGSLEE 2945
+RR + ADI L +A + + +K + + V EE+ A S E+
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1963
Query: 2946 MTQRLREFQESFKNIEKKVEG---AKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
E + I E +K Q E+ A Q + + + A++ V ++L
Sbjct: 1964 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2023
Query: 3003 QVDYLRNFTQGLVEDA---PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG- 3058
+ + R L E +A +L +AE L++ Q + E K
Sbjct: 2024 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2083
Query: 3059 -IGQFHCRVREMFSQLADLDDELDGMGAIGR-------------DTDSLQS--QIEDVRL 3102
+ Q +++ Q + D+L G R + ++ QS Q+E+
Sbjct: 2084 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2143
Query: 3103 FLNKIH------------VLKLDIEASEAECRHMLEEEGTL-DLLGLKRELEALNKQCGK 3149
KL EA + R E+ L E+E +K+ +
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-HKKFAE 2202
Query: 3150 LTERGKARQEQLELTLGRVE----DFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
T R KA+ EQ ELT R++ D + L AE EA + E E+ + +
Sbjct: 2203 QTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2261
Query: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265
+ Q E++ L+ +++ N + LI KD + L+ + E++ K+V
Sbjct: 2262 V------QMEELSKLKARIEAEN---RALILR-DKDNTQRFLQEEAEKM--------KQV 2303
Query: 3266 AQRIAQLQEALLHCGKFQD-ALEPLLSWLADTEELIANQKPPSAEYKVVKAQ---IQEQK 3321
A+ A+L A + + A E L A E+++ + E +KA+ +Q+QK
Sbjct: 2304 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2363
Query: 3322 LL-----QRLLDDRKATVDML--QAEGGRIAQSAELADREKITGQLESLESRWTELLSKA 3374
L +RL +D++ L + +G + AE + +++ + E L+ R E+ S+A
Sbjct: 2364 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRA 2422
Query: 3375 AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKA-- 3431
AR + ED A++F + AE I + L TE LA E V QT +IQ+Q H A
Sbjct: 2423 QARAE--ED----AQRFRKQAEEIGEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAER 2474
Query: 3432 LEE---DIENHATDVHQAVKIGQ------------SLSSLTSPAEQGVLSEKIDSLQARY 3476
L E ++E + Q K+ Q L T +Q LSEK DSL R
Sbjct: 2475 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-DSLLQRE 2533
Query: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEV------------------------------- 3505
I+ + L ++ A+ E++
Sbjct: 2534 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2593
Query: 3506 ----EVLNWLAEVEDKLSSVFVKDFKQ-----DVLHRQHADHLALNEEIVNRKKNVDQAI 3556
E L L + + + ++ ++ +L QH LA +EE+ + + +
Sbjct: 2594 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2653
Query: 3557 KNGQALLKQTTGEEVLLIQEKLDGIK-----TRYADITVTSSKALRTLEQ 3601
NG+ L E + DG++ R + + S++ L+ L Q
Sbjct: 2654 PNGRDALDGPAAEAE--PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2701
Score = 100 bits (249), Expect = 4e-20
Identities = 318/1624 (19%), Positives = 619/1624 (38%), Gaps = 261/1624 (16%)
Query: 3221 QMKLQ-QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC 3279
Q K Q +V GLG+G+ + + + V L E + TL ++ + +L++
Sbjct: 1053 QQKAQAEVEGLGKGVARLSAEAEKVLALP----EPSPAAPTLRSELELTLGKLEQVRSLS 1108
Query: 3280 GKFQDALEPLLSWLADT---EELIANQKPPSAEYKVVKAQIQEQ-------KLLQRLLDD 3329
+ + L+ + + T EE++ + E + V A + E K L+ +
Sbjct: 1109 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1168
Query: 3330 RKATVDMLQAE-------GGRIAQSAELAD------REKITGQLESLESRWTELLSKAAA 3376
++ T D L+ E G R+ Q D RE++ LE RW +L++
Sbjct: 1169 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE----RWQAVLAQTDV 1224
Query: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKALEED 3435
RQ++LE + + + E+A+P+ +L ++ + + + +++Q+ + +AL E+
Sbjct: 1225 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1284
Query: 3436 IENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495
IE H V + + A+Q + + K LQ + Q A + S
Sbjct: 1285 IERHGEKVEECQRF----------AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1334
Query: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD-Q 3554
+ ++ V++ +E+ L+S ++K + + + + LA + R++ + +
Sbjct: 1335 GSESVIQEYVDLRTHYSEL-TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1393
Query: 3555 AIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 3614
A Q L + + + + ++ R + V +A +Q + +S E
Sbjct: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK------RSIQE 1447
Query: 3615 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLD-TVNEVSRALLE 3673
EL + E E+ Q+ E + + +++E+ RL L+ T + A E
Sbjct: 1448 ELQQLRQSSEAEIQAKARQAEAAE------RSRLRIEEEIRVVRLQLEATERQRGGAEGE 1501
Query: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----QAADAELAWV 3729
L RAR +A Q + + + ++ QR +Q E AE
Sbjct: 1502 LQALRAR------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1555
Query: 3730 AETKRKLMALGPIRL---EQDQTTAQLQVQKAFSIDI---IRHKDSMDELFSHRSEIFGT 3783
E +R L AL +RL E ++ Q +V++A + + + + EL S R+
Sbjct: 1556 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF--- 1612
Query: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW-IEETR 3842
+KT E+ SL +++ A++ L E R ++ E EL W ++
Sbjct: 1613 ---AEKTAQLER--SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1667
Query: 3843 ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902
AL +L + + ++ Q E +Q E+ E + + +E + E+ E+
Sbjct: 1668 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------GKAEEQAVRQRELAEQ 1719
Query: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962
+ +K Q+ E Q+ LA ++ + + TE ++ +LE E L+ R+
Sbjct: 1720 ELEKQR----QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE--EELA---RLQREA 1770
Query: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4022
A K +E ++ E+E L S K R EE RS + + +
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLAS----KARAEE-ESRSTSEKSKQRLEAEAGRFRE 1825
Query: 4023 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4082
+ ++A AEE + + +LAE+ A + + + L + G + + +
Sbjct: 1826 LAEEAARLRALAEEAKRQ----RQLAEE-----DAARQRAEAERVLAEKLAAIG-EATRL 1875
Query: 4083 KQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT 4142
K + E A KE E E +R L D F E+ + D + L K
Sbjct: 1876 KTEAEIALKEKE------AENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKA 1928
Query: 4143 WKERLEK----LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP-PVGTDLNTVKDQLNE 4197
LE+ +ED ++ Q ++ + A+ + + +G + +D L
Sbjct: 1929 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1988
Query: 4198 MKEFKVEVYQQQ---IEMEKLNHQGELMLKK--ATDETDRDIIREPLTELKHLWENLGE- 4251
++ ++E +Q+ E E+ + E ++K A +E + L E++ L + E
Sbjct: 1989 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048
Query: 4252 -KIAHRQHKLEGALLALGQ-----------------FQHALEELMSWLTHTEELLDAQRP 4293
++ R + L L Q Q +EL L + +LD R
Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2108
Query: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN----ELLESSAGDDASSLRSRLE 4349
E E A+ + + QA E E L+ SA + A +
Sbjct: 2109 --------EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2160
Query: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE--------------DFLLELTRMES 4395
A + + Q+ R Q Q+ L+Q Q +E+E ELT +
Sbjct: 2161 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2220
Query: 4396 QLSASKPTGGL------------PETAREQLDTHMELY---------SQLKAKEETYNQL 4434
QL + L E AR++ EL+ S+LKA+ E N+
Sbjct: 2221 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2280
Query: 4435 L---DKGRLMLLSRDDSGSGSKTEQSVALLE------------------QKWHVVSSKME 4473
L DK ++++ + + A L Q+ + ++
Sbjct: 2281 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2340
Query: 4474 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI-----EEHK 4528
E+ ++EA L E + L +Q +A + L Q+ EE +
Sbjct: 2341 EKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2389
Query: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588
F + A R + +E+ +LK + + Q+R E+ QR ++ +
Sbjct: 2390 GFQRTLEAERQRQLEMSAEAERLKLRVAE---------MSRAQARAEEDAQRFRKQAEEI 2440
Query: 4589 DDARKRAKQFHEAWKKLIDWLE--------DAESHLDSELEISNDPDKIKLQ---LSKHK 4637
+ R + + L+ LE DAE ++ E+ + +K++ + L
Sbjct: 2441 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2500
Query: 4638 EFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDS-QKLDNFLGEVRDKWDTVCGKSVERQH 4696
E +T+ +Q + +T +AL++ L +DS + + F+ + + K + + V +
Sbjct: 2501 EEMQTVQQEQLLQET-----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2555
Query: 4697 KLEE 4700
+L E
Sbjct: 2556 QLRE 2559
Score = 67.0 bits (162), Expect = 5e-10
Identities = 235/1255 (18%), Positives = 480/1255 (38%), Gaps = 105/1255 (8%)
Query: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 3922
EE RQ S+ + H L+ PE+ M E +Y + Y Q+ + + Q A
Sbjct: 947 EEQRQALHSL---ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGA 1003
Query: 3923 LALDEAVSQSTQITEFHDKIEPMLETLENLS-SRLRMPPLIPAEVDKIREC---ISDNKS 3978
E I+E D I LE E + RLR +P + + REC I++ +
Sbjct: 1004 ---QEESRCQRCISELKD-IRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQK 1055
Query: 3979 ATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038
A E+E L L E+++ + + AA ++ +L+ + E +++
Sbjct: 1056 AQAEVEGLGKGVARLSAEAEKVLALPEPSP---AAPTLRSELELTLGKLEQVRS-LSAIY 1111
Query: 4039 IKFLDVLELAEKFWYDMAALLTT----IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094
++ L + L + +L +K+ Q + L + +K+ AE +
Sbjct: 1112 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1171
Query: 4095 ETDGLHEELEFIRILGADLIFACGE--TEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152
D L +EL + +G L GE E R+ + ++ W+ + R +LE
Sbjct: 1172 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231
Query: 4153 AMQAAVQYQDTLQAMFDWLDNT---VIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQ-- 4207
+ Y+++ + WL + ++ MP D V++QL + + E+ +
Sbjct: 1232 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL--ADSQAVREQLRQEQALLEEIERHG 1289
Query: 4208 ------QQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN---LGEKIAHRQH 4258
Q+ + +N + L+ T + + + P + K + + E + R H
Sbjct: 1290 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1349
Query: 4259 KLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--------LAKHHV 4310
E L Q+ + E + + E L + QR + ++ EVE LA+ H
Sbjct: 1350 YSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHA 1407
Query: 4311 LKNDVLAHQATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4368
+ A + E + E++ E +A D RS E + Q +S + + + +Q
Sbjct: 1408 -QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1466
Query: 4369 LQSTLQQAQGFHSEIEDFLLELTRMESQLSAS----KPTGGLPETAREQLDTHMELYSQL 4424
++ + EI L+L E Q + + E A Q E +L
Sbjct: 1467 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1526
Query: 4425 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA-L 4483
+ + + +Q + + L SR + + + E+ AL Q + + EE + +L +A +
Sbjct: 1527 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEV 1584
Query: 4484 NLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA---NEVNAHRDQ 4540
A + Q +L E AE AS S EEH A E Q
Sbjct: 1585 ERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1643
Query: 4541 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI---ERGRSLDDARKRAKQ 4597
E ++ + + ++ + + L + +Q+ E Q+S+ E + ++A + A++
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARR 1702
Query: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH--KEFQKTLGGKQPVYDTTIR 4655
+A ++ + E AE L+ + +++ + +L + + +T G+Q
Sbjct: 1703 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1762
Query: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
R +E + Q+L+ L +VR + + + + EE+ S + L+A
Sbjct: 1763 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAE 1819
Query: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775
++ + A + + Q++L + Q R E
Sbjct: 1820 AGRFRELAEEAAR-----------LRALAEEAKRQRQLAEEDAARQ------RAEAERVL 1862
Query: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF--RDTVHMLLEWLSEAEQT 4833
+ G+ L T + K ++ RL + L + E F R + ++ E+
Sbjct: 1863 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1921
Query: 4834 L-RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKH 4892
L + R A + E + L++ ++VEE+ + + ++ A + +
Sbjct: 1922 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1981
Query: 4893 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIP 4952
+R++ + L A+Q Q E A + + L A + A R ++
Sbjct: 1982 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA------RQRKAAL 2035
Query: 4953 QNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI---EPTHAPFIEKSRSGGRKS 5009
+ ++R+KA + E + E ++ ++ + +K + E HA +++ +++
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095
Query: 5010 LSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064
L Q + ++EA + Q A + +R++ +A +RL++ E
Sbjct: 2096 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAE 2149
Score = 39.7 bits (91), Expect = 0.082
Identities = 26/54 (48%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 5350 SASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRR 5403
S S GS AGSR GSR SR GS FD T S S T SS+ G RR
Sbjct: 4506 SVSGSGSTAGSRTGSRTGSRAGSRRGSFD--ATGSGFSMTFSSSSYSSSGYGRR 4557
Score = 34.3 bits (77), Expect = 3.5
Identities = 49/247 (19%), Positives = 98/247 (39%), Gaps = 25/247 (10%)
Query: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635
+V +S++R L+D+ R Q L+ W+E+ + +D E D ++ QL
Sbjct: 532 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 584
Query: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEK-TLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
H+ G Q + + + RA ++ L P + LG + ++ + S R
Sbjct: 585 HR------GLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 638
Query: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLM---DAHKVFQK 4751
LE F+ A + WL + E E++ D N+ +++ +
Sbjct: 639 LRSLESL----HSFVAAATKELMWLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMR 690
Query: 4752 ELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALK 4811
EL + ++ L+ +G L+ V+ L T+W + +L ++ L++
Sbjct: 691 ELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAA 750
Query: 4812 QAEVFRD 4818
+ F D
Sbjct: 751 YFQFFSD 757
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 1382 bits (3578), Expect = 0.0
Identities = 927/2811 (32%), Positives = 1492/2811 (53%), Gaps = 246/2811 (8%)
Query: 52 QKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHN 111
+K+ S+D++ RA DERDRVQKKTFTKWVNKHL+K ++HI+DLYEDLRDGHN
Sbjct: 16 RKRTSSEDNLYLAVLRASEGKKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHN 75
Query: 112 LISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLG 171
LISLLEVLSG LPREKGRMRFH+LQNVQIALD+L+ RQVKLVNIRNDDI DGNPKLTLG
Sbjct: 76 LISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLG 135
Query: 172 LIWTIILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNA 231
LIWTIILHFQISDI +SG+S DM+AKEKLLLW+Q++ GY G++C NF+S W DG++FNA
Sbjct: 136 LIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA 195
Query: 232 LIHRYRPDLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYV 290
+IHR++P L+DM +V Q+N ENL+QAF VAER LGVTRLLD EDVDVP PDEKS+ITYV
Sbjct: 196 IIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYV 255
Query: 291 SSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELK 350
SS+YDA P+VP+ +G+ A E+ RWQEY+ V L+ W++ HT ++ FP + E++
Sbjct: 256 SSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIE 315
Query: 351 ALYNQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLII 410
L++Q++ FKE E+ AKE +K R + +Y+ LE ++ G++K+P GYHP DVE+EWGKL +
Sbjct: 316 ILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV 375
Query: 411 EMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCE 470
+LEREK LR ERLE L +I K+Q A CEE+L A LQ+D L +G+ Q
Sbjct: 376 AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRA 435
Query: 471 SDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKG 530
+V + + + +IR L D+Q L+D + Q E++ RV RL + LV +R E + G
Sbjct: 436 GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG 495
Query: 531 HFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVY 590
A P T+ + S R+P EL ++ LR++
Sbjct: 496 ------------------VAAPATQVAQVTLQSVQRRP----EL-------EDSTLRYLQ 526
Query: 591 ELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNF 650
+LL+WVEE Q +++ AEWG DLPSVE QL + + +H S+EE + ++ AR EG++S
Sbjct: 527 DLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPAT 586
Query: 651 HTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSD 710
+Y + LG+L+ QY KL +S R+R L+SLH FV+ AT EL+WLNEKEEEE+ +DWSD
Sbjct: 587 RGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSD 646
Query: 711 NNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQW 770
N+N++AK+ +S L ELE K+ + LQ+ + L E+HPA+ TVE++ AA+Q+Q W
Sbjct: 647 RNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSW 706
Query: 771 MKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQD 830
M QLC C+E H+KEN AYFQFFSD RE E L+ LQ++++RKYSCD + +++RLEDLLQD
Sbjct: 707 MLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQD 766
Query: 831 SMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKND 890
+ DEKEQL + K ++ L R+K +VQLKPR P H ++ + + AVCDY+Q+E+T+ K D
Sbjct: 767 AQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGD 826
Query: 891 ECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQL 950
EC L +Q + WKV+S +G+EA VPSVCFL+PPPN++A E +R+E +Q ++ LWHQL
Sbjct: 827 ECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQL 886
Query: 951 HVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLF 1010
HV+ KSL++W LR+D+ L+++W+L R+ P E Q + +L+ HY+ FL+DS+D+ F
Sbjct: 887 HVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGF 946
Query: 1011 SVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKR 1070
DRL E E +C +Q L++S+E +EE+ + ISELK+IRL+LE E R V R
Sbjct: 947 GPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR 1006
Query: 1071 IQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPT 1130
++ D++ ++ A RIAEQ+ Q +++ L + +S + + L S + PT
Sbjct: 1007 LR----LPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT 1062
Query: 1131 LRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADL 1190
LRSEL L + K++ V LS +YL KLKT+ +++R Q AE +++ +E +L + + V A L
Sbjct: 1063 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1122
Query: 1191 SALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGS 1250
LEA ++L+ + + + F L +E+ A+ V E++ + ER++++ER++E+ +
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1182
Query: 1251 QLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSR 1310
QL ERW V+AQ ++RQ ELE + L YR L W+++ +QE ++ DS+
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 1311 VLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGK 1370
+ EQL Q+ AL EIER+ K+++CQ+F++QY +KDYELQL+TYKA +E SP K
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPAK 1301
Query: 1371 RRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEK 1430
+ ++ S S+++ QE++DLRT Y+ L TLT+Q++K+IS+ LRR+EEEE++ E+++ E E+
Sbjct: 1302 KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER 1361
Query: 1431 VKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI 1490
+ E+ + L + Q ++ K + E L+Q+ + EE+ ++E +A
Sbjct: 1362 LAEV---EAALEKQRQLAEAHAQAKAQAEREAKELQQR-MQEEVVRREEAAVDA------ 1411
Query: 1491 FLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQ-SQLAHQTEQKTLQKQQ 1549
+++K+ I E+L L ++ A Q + + S+L + E + ++ Q
Sbjct: 1412 ----------QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 1550 NTCHQQL----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATS 1605
+Q +L + +AE A A Q R Q++ L+ + +QD+ Q + +
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEA--QKRQAQEEAERLR------RQVQDESQRKRQA 1513
Query: 1606 FATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSAL 1665
+ ++ E + K R L AL E QA+E E R+ Q E+E A +
Sbjct: 1514 EVELASRVKAEAEAAREK--QRALQALEELRLQAEE------AERRLRQAEVERARQVQV 1565
Query: 1666 QQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTT 1725
ET + A EL + S QL +L E ++ A L + A
Sbjct: 1566 ALETAQRSAEAELQSKR----------ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRA 1614
Query: 1726 DGYMGVNQAPEKLDKQCEMMKARHQELLS---QQQNFILATQSAQAFLDQHGHNL----- 1777
+A E+ +++ E + + E L Q + AQA ++
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 1778 ---TPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERS 1834
EEQ + Q++L E + + LA+ A+ Q + EL + + ++ E +
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ--QRLAAEQELIRLRAETEQGEQQRQLL 1732
Query: 1835 EKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE 1894
E+EL + + E + KRQ ++ + ++ + S + + S E
Sbjct: 1733 EEELARLQR-----EAAAATQKRQ-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS- 1785
Query: 1895 PSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEAN 1954
K +L+ R+ L + RL + L + + Q A Q EA
Sbjct: 1786 --------KQRLEAEAGRFRELAEEAARLRA-----LAEEAKRQRQLAEEDAARQRAEA- 1831
Query: 1955 VEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARD----IMEIEGEPAP 2010
E++L++ +A+ + E + + L E + E+L+++A D +E + A
Sbjct: 1832 -ERVLAEKLAA----IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1886
Query: 2011 DHRHVQETTDSILSHFQSLSYSLAER-SSLLQKAIAQSQSVQESLESLLQSIGEVEQNLE 2069
++E L+ + S S ER L++ + Q + V+E + +L S E+
Sbjct: 1887 HKADIEER----LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF---EKAAA 1939
Query: 2070 GKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLA 2129
GK L G I+ ++ +++++ LEA R+ AA + +
Sbjct: 1940 GKAELELELGRIRSNAEDTLR-----SKEQAELEAARQ----------RQLAAEEERRRR 1984
Query: 2130 EVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITH 2189
E +R ++ ++E K L + E + + ++ E + A Q Q+
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 2190 FFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVK 2249
Q +E QQ+ + + L E S L Q + + R+ E ++
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSV------LDQLRGEAEAARRAAEEAEEARV 2098
Query: 2250 EREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDW 2309
+ E++A+ + Q++E +L ++ + E + + + + E L+ +
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAE-------------EQAQARAQAQAAAEKLRKEAEQE 2145
Query: 2310 ASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2369
A++ E+ + + ME ++ T + +++
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAE--------------------QTLRQKAQVE 2185
Query: 2370 CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSS 2429
+++ + L+ E+ + E LQ + E ++ + V + L S ++ + + +
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 2430 PTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNS 2489
+ E L++ + K+++V E A L V +QEA +++ EE +
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLRQLAEEDLA 2302
Query: 2490 RWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ 2549
+ E + + Q + A+ L AE++L +KEL L D + Q
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRL----KAEAELLQ--QQKELAQEQARRLQEDKEQMAQQ 2356
Query: 2550 -KQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDK 2608
++ Q + EA RQ+ +++ A+ + ++S + ++ +++ Q ++ E+ +K
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416
Query: 2609 LNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIR 2668
L+ R+ Q EKV V Q L +Q S ++ E +E+
Sbjct: 2417 LH-RTELATQ----------------EKVTLV-QTLEIQRQQSDHD--AERLREAIAELE 2456
Query: 2669 SDLEQLDHEVKEAQTLCDELSVLIGEQYL-------------KDELKKRLETVALPLQGL 2715
+ E+L E K Q +E+ + EQ L KD L +R + L
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 2716 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 2775
E L D + + Q Q+ QQ ++ R L + + + E + ++ E
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR-----QHEAEEGVRRKQE 2571
Query: 2776 EFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS 2826
E Q+ Q E++ E + L E+ + L+ Q H EE++
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRL------REQLQLLEEQHRAALAHSEEVT 2616
Score = 131 bits (329), Expect = 2e-29
Identities = 322/1752 (18%), Positives = 693/1752 (39%), Gaps = 241/1752 (13%)
Query: 2635 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE 2694
E R QR++ Q + E + + + S + L A TL EL + +G+
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073
Query: 2695 ----QYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750
+ L ++L+T++L ++G + A + + + L Q EL
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQG-AEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132
Query: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810
+ +A+ + L+ +L+ +E + L Q G +V E
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV----------------EVER 1176
Query: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV- 2869
+ ++ +L W+ + +T RQ L+ ++ + Y+ + L W++D + + +++
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236
Query: 2870 -TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQN 2928
D + L + +A+L E+E+ +E A IN+ + E + KA + +
Sbjct: 1237 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-EP 1295
Query: 2929 MDAVTEELQAKTGSLEEMTQRLREFQESFKNIE-------KKVEGAKHQLEIFDALGSQA 2981
+ + ++ + ++GS E + Q + + + + K + ++E + L Q
Sbjct: 1296 VASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ- 1353
Query: 2982 CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV 3041
+ E+ EV ALE Q Q + A++E E+
Sbjct: 1354 ---QRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-----------------AEREAKEL 1393
Query: 3042 KQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD-ELDGMGAIGRDTDSLQSQIEDV 3100
+QR+ V E Q ++E QL + E+ + + +IE+
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1452
Query: 3101 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQ 3160
+I V++L +EA+E + G G + EL+AL + + + + QE+
Sbjct: 1453 -----EIRVVRLQLEATE-------RQRG-----GAEGELQALRARAEEAEAQKRQAQEE 1495
Query: 3161 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPL 3220
E +V+D ++ + + +AEA E + Q L + ++ Q +
Sbjct: 1496 AERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRL----QAEEA 1548
Query: 3221 QMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME-EINARWNTLNKKVAQRIAQLQEALLHC 3279
+ +L+Q +Q A ++ + E E+ ++ + +K AQ LQE +
Sbjct: 1549 ERRLRQAEVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603
Query: 3280 GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT--VDML 3337
+ ++ E A+ E + AE ++ + Q++ + L+ L + +
Sbjct: 1604 AQLREEAERRAQQQAEAE-----RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397
QAE + + AE R + G+ E R EL + +Q+QL + A+Q +
Sbjct: 1659 QAEAEKQKEEAEREARRR--GKAEEQAVRQRELAEQELEKQRQLAE--GTAQQRLAAEQE 1714
Query: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKI---GQSLS 3454
+ + TE+ + + + A++Q++ +++E V +++ ++ +
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774
Query: 3455 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED----------- 3503
S + +++++ R+ E+ + R AL ++A +L ED
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 3504 ----------------EVEVLNWLAEVEDKLSSVFVKD--FKQDVLHRQHADHLA-LNEE 3544
E E+ E E++ +D F++ L Q A H A + E
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 3545 IVNRKKNVDQAIKNGQALLKQT------TGEEVLLIQEKLDGIKTRYADITV-------T 3591
+ +K D ++ + L++ T EE+L ++ + A++ +
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954
Query: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS-GGQSPTGEQIPQFQQRQKEL 3650
+ LR+ EQA A + + E RE EE + S + Q + + L
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014
Query: 3651 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA 3710
K +V E R + + + S L+L A+E K + + + V + +
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQL----AQEAAQKRLQAEEKAHAFA-------VQQKEQ 2063
Query: 3711 AIQRSQQYEQAADAELAWVAETKRKLMALGP---IRLEQDQTTAQLQVQKAFSIDIIRHK 3767
+Q++ Q EQ+ +L AE R+ ++ E++ ++ QV++A R K
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-----ERLK 2118
Query: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKT------ESLIQQYEA--ISLLNSERYAR--- 3816
S +E R++ + +K QE ++ ++Q +A + +++A
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 3817 LERAQV------LVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 3870
++AQV L Q ET + + EE + L A+ A Q+ ++ +R E
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238
Query: 3871 SIAEHKPHIDK-----LLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALAL 3925
+++ K I+ +L+ + EE E +++ ++A + +E R R LA
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA- 2297
Query: 3926 DEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEK 3985
+E ++Q + E + + E ++ + R + AE + +++ + A + +
Sbjct: 2298 EEDLAQQRALAE-----KMLKEKMQAVQEATR----LKAEAELLQQ---QKELAQEQARR 2345
Query: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045
LQ E ++ ++L +QG + L A E Q +L ++ A AE +++ ++
Sbjct: 2346 LQ---EDKEQMAQQLAEETQGFQRTLEA-ERQRQL--------EMSAEAERLKLRVAEMS 2393
Query: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105
+ D ++ + +H E +++V +T++ + + E
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEIQRQQSDHDAER 2447
Query: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER-LEKLEDAMQAAVQYQDTL 4164
+R A+L E EK ++++ + E + +E+ L++ + Q+ + +D+L
Sbjct: 2448 LREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502
Query: 4165 QAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK 4224
+++ KL + +D++ + ++ + E +QQ +ME+ + ++
Sbjct: 2503 LQRERFIEQEKAKLEQL---------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Query: 4225 KA---TDETDRDIIR--EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4279
+A E + + R E L +L+ E +A +L Q Q E+ +
Sbjct: 2554 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR------EQLQLLEEQHRA 2607
Query: 4280 WLTHTEELLDAQ 4291
L H+EE+ +Q
Sbjct: 2608 ALAHSEEVTASQ 2619
Score = 129 bits (325), Expect = 6e-29
Identities = 545/2630 (20%), Positives = 996/2630 (37%), Gaps = 398/2630 (15%)
Query: 1209 DKNSVFSVLD-EEIAKAKVVAEQ---MSRLTPERNLDLERYQEKG-----SQLQERWHRV 1259
D N V+ + E + +A VAE+ ++RL ++D+ + EK S L + RV
Sbjct: 206 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 265
Query: 1260 I-AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKPGQAEDSRVLSEQLS 1317
Q +R +EL+ + +YR L++W+ TA +E P E+ +L Q
Sbjct: 266 PDVQDGVRANELQLRWQ---EYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 322
Query: 1318 QQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSS 1377
+ + E+ + ++ + Q V+ +L++ PG
Sbjct: 323 KFKEM--ELPAKEADKNRSKGIYQSLEGAVQAGQLKV------------PPGYHP----- 363
Query: 1378 SDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGW 1437
+D+ + L + K + RLE +++V + + E +E L
Sbjct: 364 --------LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME-AGLCEEQLNQ 414
Query: 1438 VSTLARN-----TQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFL 1492
L ++ GK + D++KA ++L ++ T K+
Sbjct: 415 ADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD------------- 461
Query: 1493 AKH--GHKLSEKEKKQISEQLNALNKAYH-DLCDGSANQLQQLQSQLAHQTEQKTLQKQQ 1549
+H G ++ + + + E+L A+ Y+ L G A Q+ +Q+ Q+ Q+ + +
Sbjct: 462 GRHPQGEQMYRRVYR-LHERLVAIRTEYNLRLKAGVAAPATQV-AQVTLQSVQRRPELED 519
Query: 1550 NTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATV 1609
+T + L+DL +WV + + + G + DL +++ + L I+
Sbjct: 520 STL-RYLQDLLAWVEENQHRVDGAEWGV---DLPSVEAQLGSHRGLHQSIEEFRAKIERA 575
Query: 1610 VKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
D + +LSP A R+ L + QY L ++ + LE +
Sbjct: 576 RSD--------EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV----- 622
Query: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729
+ A KEL +K + VG TN+ ++ A + + L
Sbjct: 623 --AAATKELMWLNEKEEE------EVGFDWSDRNTNMTAKKESYSALMRELELKEKK-IK 673
Query: 1730 GVNQAPEKL---DKQCEMMKARHQELLSQQQNFIL-------ATQSAQAFLDQHGHNLTP 1779
+ A ++L D Q L Q +++L A A Q ++
Sbjct: 674 ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 733
Query: 1780 EEQQMLQQKLGE-LKEQYSTSLAQSEAELKQV-QTLQDELQKFLQDHKEFESWLERSEK- 1836
E Q+ QKL E L+ +YS + + L+ + Q QDE ++ L ++K S L + K
Sbjct: 734 AEGQL--QKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ-LNEYKGHLSGLAKRAKA 790
Query: 1837 --ELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQ----KVLDMENSFK 1890
+L+ H LP LL +V HKGD + Q KVL S
Sbjct: 791 VVQLKPRHPAHPMRGRLP-LLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-- 847
Query: 1891 EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950
E PS + LV ++A E T RL + L+ +HQ SL AW Q+
Sbjct: 848 EAAVPS-VCFLVPPPNQEAQEAVT-------RLEAQHQALVTLWHQLHVDMKSLLAW-QS 898
Query: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010
+V+ + S ++A+ T K ++ A H + + Q RD + G
Sbjct: 899 LRRDVQLIRSWSLAT--------FRTLKPEEQRQALHSLELH-YQAFLRDSQDAGGFGPE 949
Query: 2011 DHRHVQETTDSILSHFQSLSYSL---AERSSLLQKAIAQSQSVQESLESL-LQSIGEVEQ 2066
D + S H+Q L SL A+ S Q+ I++ + ++ LE+ +++ +
Sbjct: 950 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1009
Query: 2067 NLEGKQVSSLSSGVI--QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2124
L+ + + + Q+A A L + +AR L A E V E S A L
Sbjct: 1010 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR----LSAEAEKVLALPEP--SPAAPTL 1063
Query: 2125 QGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2181
+ +L + EQ L EK ++ ++ + E + ++ ++ + A+
Sbjct: 1064 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT-- 1121
Query: 2182 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---------DLCQHQD 2232
P+ + T +++L + E QQ D L + G L ++ + ++
Sbjct: 1122 LPELEATK--ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1179
Query: 2233 RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSA 2292
RV L + + + R+++ QL +R+ WL++ + A
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1239
Query: 2293 --KELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME-----ITAPDSQGKTGSI 2345
+ + +Q+ ++LL++ G VEE N I + +T S
Sbjct: 1240 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1299
Query: 2346 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2405
GS + DL +++ + +Y K R E + + + +
Sbjct: 1300 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359
Query: 2406 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2465
E + ++ K+ L A + K + + + E+ + Q+ K ++
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 2466 GLLVTYPNSQEAENWKKIQE----------------------------------ELNSRW 2491
L S EAE K ++ EL +
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 2492 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 2551
RA E A++RQ +E A L ESQ R E EL V A +
Sbjct: 1480 ARAEEAE-AQKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 2552 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ--VQKELQSINQKWVELTDKL 2609
+ L+ EA R+ + E A+ + V+L T+Q + ELQS + E T +L
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQV-----QVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 2610 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRS 2669
RS Q + V L++ +E+ RA Q + ++ + E + QL+ +R
Sbjct: 1593 E-RSLQEEHVAVAQ------LREEAER-RAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 2670 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK-RLETVALPLQGLEDLAADRINRLQA 2728
L+ EV + ++L + E+ ++ ++ + E A+ + L + ++ +L
Sbjct: 1645 RLQA--EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1702
Query: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQL----QENEEFQKSLNQH 2784
A Q+ + +R + +Q +Q + + +L RLQ + Q+ +E + L +
Sbjct: 1703 GTAQ-QRLAAEQELIRLRAETEQGEQQRQL-LEEELARLQREAAAATQKRQELEAELAKV 1760
Query: 2785 SGSYEVIVA-----EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK-----KTADRQS 2834
EV++A E ES S + K+ L+ + + EE ++ + A RQ
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSE---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Query: 2835 RLKD---CMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVE 2891
+L + Q+A+ + E L E + K +E + L + E+ LR A +
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 2892 KRRSLLEILNSAADI---LINSSEADEDGIRDEKAGINQNMDA---VTEELQAKTGSLEE 2945
+RR + ADI L +A + + +K + + V EE+ A S E+
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1936
Query: 2946 MTQRLREFQESFKNIEKKVEG---AKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
E + I E +K Q E+ A Q + + + A++ V ++L
Sbjct: 1937 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996
Query: 3003 QVDYLRNFTQGLVEDA---PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG- 3058
+ + R L E +A +L +AE L++ Q + E K
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056
Query: 3059 -IGQFHCRVREMFSQLADLDDELDGMGAIGR-------------DTDSLQS--QIEDVRL 3102
+ Q +++ Q + D+L G R + ++ QS Q+E+
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2116
Query: 3103 FLNKIH------------VLKLDIEASEAECRHMLEEEGTL-DLLGLKRELEALNKQCGK 3149
KL EA + R E+ L E+E +K+ +
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-HKKFAE 2175
Query: 3150 LTERGKARQEQLELTLGRVE----DFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
T R KA+ EQ ELT R++ D + L AE EA + E E+ + +
Sbjct: 2176 QTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265
+ Q E++ L+ +++ N + LI KD + L+ + E++ K+V
Sbjct: 2235 V------QMEELSKLKARIEAEN---RALILR-DKDNTQRFLQEEAEKM--------KQV 2276
Query: 3266 AQRIAQLQEALLHCGKFQD-ALEPLLSWLADTEELIANQKPPSAEYKVVKAQ---IQEQK 3321
A+ A+L A + + A E L A E+++ + E +KA+ +Q+QK
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Query: 3322 LL-----QRLLDDRKATVDML--QAEGGRIAQSAELADREKITGQLESLESRWTELLSKA 3374
L +RL +D++ L + +G + AE + +++ + E L+ R E+ S+A
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRA 2395
Query: 3375 AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKA-- 3431
AR + ED A++F + AE I + L TE LA E V QT +IQ+Q H A
Sbjct: 2396 QARAE--ED----AQRFRKQAEEIGEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAER 2447
Query: 3432 LEE---DIENHATDVHQAVKIGQ------------SLSSLTSPAEQGVLSEKIDSLQARY 3476
L E ++E + Q K+ Q L T +Q LSEK DSL R
Sbjct: 2448 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-DSLLQRE 2506
Query: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEV------------------------------- 3505
I+ + L ++ A+ E++
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 3506 ----EVLNWLAEVEDKLSSVFVKDFKQ-----DVLHRQHADHLALNEEIVNRKKNVDQAI 3556
E L L + + + ++ ++ +L QH LA +EE+ + + +
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2626
Query: 3557 KNGQALLKQTTGEEVLLIQEKLDGIK-----TRYADITVTSSKALRTLEQ 3601
NG+ L E + DG++ R + + S++ L+ L Q
Sbjct: 2627 PNGRDALDGPAAEAE--PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2674
Score = 100 bits (249), Expect = 4e-20
Identities = 318/1624 (19%), Positives = 619/1624 (38%), Gaps = 261/1624 (16%)
Query: 3221 QMKLQ-QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC 3279
Q K Q +V GLG+G+ + + + V L E + TL ++ + +L++
Sbjct: 1026 QQKAQAEVEGLGKGVARLSAEAEKVLALP----EPSPAAPTLRSELELTLGKLEQVRSLS 1081
Query: 3280 GKFQDALEPLLSWLADT---EELIANQKPPSAEYKVVKAQIQEQ-------KLLQRLLDD 3329
+ + L+ + + T EE++ + E + V A + E K L+ +
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141
Query: 3330 RKATVDMLQAE-------GGRIAQSAELAD------REKITGQLESLESRWTELLSKAAA 3376
++ T D L+ E G R+ Q D RE++ LE RW +L++
Sbjct: 1142 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE----RWQAVLAQTDV 1197
Query: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKALEED 3435
RQ++LE + + + E+A+P+ +L ++ + + + +++Q+ + +AL E+
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 3436 IENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495
IE H V + + A+Q + + K LQ + Q A + S
Sbjct: 1258 IERHGEKVEECQRF----------AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1307
Query: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD-Q 3554
+ ++ V++ +E+ L+S ++K + + + + LA + R++ + +
Sbjct: 1308 GSESVIQEYVDLRTHYSEL-TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366
Query: 3555 AIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 3614
A Q L + + + + ++ R + V +A +Q + +S E
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK------RSIQE 1420
Query: 3615 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLD-TVNEVSRALLE 3673
EL + E E+ Q+ E + + +++E+ RL L+ T + A E
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAE------RSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----QAADAELAWV 3729
L RAR +A Q + + + ++ QR +Q E AE
Sbjct: 1475 LQALRAR------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 3730 AETKRKLMALGPIRL---EQDQTTAQLQVQKAFSIDI---IRHKDSMDELFSHRSEIFGT 3783
E +R L AL +RL E ++ Q +V++A + + + + EL S R+
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF--- 1585
Query: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW-IEETR 3842
+KT E+ SL +++ A++ L E R ++ E EL W ++
Sbjct: 1586 ---AEKTAQLER--SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640
Query: 3843 ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902
AL +L + + ++ Q E +Q E+ E + + +E + E+ E+
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------GKAEEQAVRQRELAEQ 1692
Query: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962
+ +K Q+ E Q+ LA ++ + + TE ++ +LE E L+ R+
Sbjct: 1693 ELEKQR----QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE--EELA---RLQREA 1743
Query: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4022
A K +E ++ E+E L S K R EE RS + + +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLAS----KARAEE-ESRSTSEKSKQRLEAEAGRFRE 1798
Query: 4023 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4082
+ ++A AEE + + +LAE+ A + + + L + G + + +
Sbjct: 1799 LAEEAARLRALAEEAKRQ----RQLAEE-----DAARQRAEAERVLAEKLAAIG-EATRL 1848
Query: 4083 KQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT 4142
K + E A KE E E +R L D F E+ + D + L K
Sbjct: 1849 KTEAEIALKEKE------AENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKA 1901
Query: 4143 WKERLEK----LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP-PVGTDLNTVKDQLNE 4197
LE+ +ED ++ Q ++ + A+ + + +G + +D L
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 4198 MKEFKVEVYQQQ---IEMEKLNHQGELMLKK--ATDETDRDIIREPLTELKHLWENLGE- 4251
++ ++E +Q+ E E+ + E ++K A +E + L E++ L + E
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 4252 -KIAHRQHKLEGALLALGQ-----------------FQHALEELMSWLTHTEELLDAQRP 4293
++ R + L L Q Q +EL L + +LD R
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2081
Query: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN----ELLESSAGDDASSLRSRLE 4349
E E A+ + + QA E E L+ SA + A +
Sbjct: 2082 --------EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE--------------DFLLELTRMES 4395
A + + Q+ R Q Q+ L+Q Q +E+E ELT +
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2193
Query: 4396 QLSASKPTGGL------------PETAREQLDTHMELY---------SQLKAKEETYNQL 4434
QL + L E AR++ EL+ S+LKA+ E N+
Sbjct: 2194 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2253
Query: 4435 L---DKGRLMLLSRDDSGSGSKTEQSVALLE------------------QKWHVVSSKME 4473
L DK ++++ + + A L Q+ + ++
Sbjct: 2254 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2313
Query: 4474 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI-----EEHK 4528
E+ ++EA L E + L +Q +A + L Q+ EE +
Sbjct: 2314 EKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588
F + A R + +E+ +LK + + Q+R E+ QR ++ +
Sbjct: 2363 GFQRTLEAERQRQLEMSAEAERLKLRVAE---------MSRAQARAEEDAQRFRKQAEEI 2413
Query: 4589 DDARKRAKQFHEAWKKLIDWLE--------DAESHLDSELEISNDPDKIKLQ---LSKHK 4637
+ R + + L+ LE DAE ++ E+ + +K++ + L
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2473
Query: 4638 EFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDS-QKLDNFLGEVRDKWDTVCGKSVERQH 4696
E +T+ +Q + +T +AL++ L +DS + + F+ + + K + + V +
Sbjct: 2474 EEMQTVQQEQLLQET-----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2528
Query: 4697 KLEE 4700
+L E
Sbjct: 2529 QLRE 2532
Score = 67.0 bits (162), Expect = 5e-10
Identities = 235/1255 (18%), Positives = 480/1255 (38%), Gaps = 105/1255 (8%)
Query: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 3922
EE RQ S+ + H L+ PE+ M E +Y + Y Q+ + + Q A
Sbjct: 920 EEQRQALHSL---ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGA 976
Query: 3923 LALDEAVSQSTQITEFHDKIEPMLETLENLS-SRLRMPPLIPAEVDKIREC---ISDNKS 3978
E I+E D I LE E + RLR +P + + REC I++ +
Sbjct: 977 ---QEESRCQRCISELKD-IRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQK 1028
Query: 3979 ATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038
A E+E L L E+++ + + AA ++ +L+ + E +++
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSP---AAPTLRSELELTLGKLEQVRS-LSAIY 1084
Query: 4039 IKFLDVLELAEKFWYDMAALLTT----IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094
++ L + L + +L +K+ Q + L + +K+ AE +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1144
Query: 4095 ETDGLHEELEFIRILGADLIFACGE--TEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152
D L +EL + +G L GE E R+ + ++ W+ + R +LE
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 4153 AMQAAVQYQDTLQAMFDWLDNT---VIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQ-- 4207
+ Y+++ + WL + ++ MP D V++QL + + E+ +
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL--ADSQAVREQLRQEQALLEEIERHG 1262
Query: 4208 ------QQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN---LGEKIAHRQH 4258
Q+ + +N + L+ T + + + P + K + + E + R H
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322
Query: 4259 KLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--------LAKHHV 4310
E L Q+ + E + + E L + QR + ++ EVE LA+ H
Sbjct: 1323 YSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHA 1380
Query: 4311 LKNDVLAHQATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4368
+ A + E + E++ E +A D RS E + Q +S + + + +Q
Sbjct: 1381 -QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1439
Query: 4369 LQSTLQQAQGFHSEIEDFLLELTRMESQLSAS----KPTGGLPETAREQLDTHMELYSQL 4424
++ + EI L+L E Q + + E A Q E +L
Sbjct: 1440 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1499
Query: 4425 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA-L 4483
+ + + +Q + + L SR + + + E+ AL Q + + EE + +L +A +
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEV 1557
Query: 4484 NLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA---NEVNAHRDQ 4540
A + Q +L E AE AS S EEH A E Q
Sbjct: 1558 ERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616
Query: 4541 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI---ERGRSLDDARKRAKQ 4597
E ++ + + ++ + + L + +Q+ E Q+S+ E + ++A + A++
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARR 1675
Query: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH--KEFQKTLGGKQPVYDTTIR 4655
+A ++ + E AE L+ + +++ + +L + + +T G+Q
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735
Query: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
R +E + Q+L+ L +VR + + + + EE+ S + L+A
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAE 1792
Query: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775
++ + A + + Q++L + Q R E
Sbjct: 1793 AGRFRELAEEAAR-----------LRALAEEAKRQRQLAEEDAARQ------RAEAERVL 1835
Query: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF--RDTVHMLLEWLSEAEQT 4833
+ G+ L T + K ++ RL + L + E F R + ++ E+
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 4834 L-RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKH 4892
L + R A + E + L++ ++VEE+ + + ++ A + +
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954
Query: 4893 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIP 4952
+R++ + L A+Q Q E A + + L A + A R ++
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA------RQRKAAL 2008
Query: 4953 QNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI---EPTHAPFIEKSRSGGRKS 5009
+ ++R+KA + E + E ++ ++ + +K + E HA +++ +++
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 5010 LSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064
L Q + ++EA + Q A + +R++ +A +RL++ E
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAE 2122
Score = 39.7 bits (91), Expect = 0.082
Identities = 26/54 (48%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 5350 SASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRR 5403
S S GS AGSR GSR SR GS FD T S S T SS+ G RR
Sbjct: 4479 SVSGSGSTAGSRTGSRTGSRAGSRRGSFD--ATGSGFSMTFSSSSYSSSGYGRR 4530
Score = 34.3 bits (77), Expect = 3.5
Identities = 49/247 (19%), Positives = 98/247 (39%), Gaps = 25/247 (10%)
Query: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635
+V +S++R L+D+ R Q L+ W+E+ + +D E D ++ QL
Sbjct: 505 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 557
Query: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEK-TLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
H+ G Q + + + RA ++ L P + LG + ++ + S R
Sbjct: 558 HR------GLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 611
Query: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLM---DAHKVFQK 4751
LE F+ A + WL + E E++ D N+ +++ +
Sbjct: 612 LRSLESL----HSFVAAATKELMWLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMR 663
Query: 4752 ELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALK 4811
EL + ++ L+ +G L+ V+ L T+W + +L ++ L++
Sbjct: 664 ELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAA 723
Query: 4812 QAEVFRD 4818
+ F D
Sbjct: 724 YFQFFSD 730
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 1379 bits (3569), Expect = 0.0
Identities = 923/2791 (33%), Positives = 1483/2791 (53%), Gaps = 246/2791 (8%)
Query: 72 VADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRM 131
V DERDRVQKKTFTKWVNKHL+K ++HI+DLYEDLRDGHNLISLLEVLSG LPREKGRM
Sbjct: 4 VPDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM 63
Query: 132 RFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGES 191
RFH+LQNVQIALD+L+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI +SG+S
Sbjct: 64 RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS 123
Query: 192 GDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSN 251
DM+AKEKLLLW+Q++ GY G++C NF+S W DG++FNA+IHR++P L+DM +V Q+N
Sbjct: 124 EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTN 183
Query: 252 RENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISAT 310
ENL+QAF VAER LGVTRLLD EDVDVP PDEKS+ITYVSS+YDA P+VP+ +G+ A
Sbjct: 184 LENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRAN 243
Query: 311 EVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKERE 370
E+ RWQEY+ V L+ W++ HT ++ FP + E++ L++Q++ FKE E+ AKE +
Sbjct: 244 ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEAD 303
Query: 371 KGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLL 430
K R + +Y+ LE ++ G++K+P GYHP DVE+EWGKL + +LEREK LR ERLE L
Sbjct: 304 KNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQ 363
Query: 431 QIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVD 490
+I K+Q A CEE+L A LQ+D L +G+ Q +V + + + +IR L D
Sbjct: 364 RIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 423
Query: 491 LQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKA 550
+Q L+D + Q E++ RV RL + LV +R E + G A
Sbjct: 424 VQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG------------------VA 465
Query: 551 EPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGN 610
P T+ + S R+P EL ++ LR++ +LL+WVEE Q +++ AEWG
Sbjct: 466 APATQVAQVTLQSVQRRP----EL-------EDSTLRYLQDLLAWVEENQHRVDGAEWGV 514
Query: 611 DLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKE 670
DLPSVE QL + + +H S+EE + ++ AR EG++S +Y + LG+L+ QY KL
Sbjct: 515 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLN 574
Query: 671 TSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELE 730
+S R+R L+SLH FV+ AT EL+WLNEKEEEE+ +DWSD N+N++AK+ +S L ELE
Sbjct: 575 SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 634
Query: 731 EKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQ 790
K+ + LQ+ + L E+HPA+ TVE++ AA+Q+Q WM QLC C+E H+KEN AYFQ
Sbjct: 635 LKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQ 694
Query: 791 FFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVG 850
FFSD RE E L+ LQ++++RKYSCD + +++RLEDLLQD+ DEKEQL + K ++ L
Sbjct: 695 FFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 754
Query: 851 RSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTG 910
R+K +VQLKPR P H ++ + + AVCDY+Q+E+T+ K DEC L +Q + WKV+S +G
Sbjct: 755 RAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSG 814
Query: 911 NEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLV 970
+EA VPSVCFL+PPPN++A E +R+E +Q ++ LWHQLHV+ KSL++W LR+D+ L+
Sbjct: 815 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLI 874
Query: 971 QTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQ 1030
++W+L R+ P E Q + +L+ HY+ FL+DS+D+ F DRL E E +C +Q
Sbjct: 875 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQ 934
Query: 1031 HLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALR 1090
L++S+E +EE+ + ISELK+IRL+LE E R V R++ D++ ++ A R
Sbjct: 935 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR----LPLDKEPARECAQR 990
Query: 1091 IAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLST 1150
IAEQ+ Q +++ L + +S + + L S + PTLRSEL L + K++ V LS
Sbjct: 991 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1050
Query: 1151 VYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDK 1210
+YL KLKT+ +++R Q AE +++ +E +L + + V A L LEA ++L+ + + +
Sbjct: 1051 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ 1110
Query: 1211 NSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSEL 1270
F L +E+ A+ V E++ + ER++++ER++E+ +QL ERW V+AQ ++RQ EL
Sbjct: 1111 QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQREL 1170
Query: 1271 ESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQ 1330
E + L YR L W+++ +QE ++ DS+ + EQL Q+ AL EIER+
Sbjct: 1171 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1230
Query: 1331 TKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRT 1390
K+++CQ+F++QY +KDYELQL+TYKA +E SP K+ ++ S S+++ QE++DLRT
Sbjct: 1231 EKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPAKKPKVQSGSESVIQEYVDLRT 1289
Query: 1391 RYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKAT 1450
Y+ L TLT+Q++K+IS+ LRR+EEEE++ E+++ E E++ E+ + L + Q
Sbjct: 1290 HYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV---EAALEKQRQLAEA 1346
Query: 1451 SSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQ 1510
++ K + E L+Q+ + EE+ ++E +A +++K+ I E+
Sbjct: 1347 HAQAKAQAEREAKELQQR-MQEEVVRREEAAVDA----------------QQQKRSIQEE 1389
Query: 1511 LNALNKAYHDLCDGSANQLQQLQ-SQLAHQTEQKTLQKQQNTCHQQL----EDLCSWVGQ 1565
L L ++ A Q + + S+L + E + ++ Q +Q +L + +
Sbjct: 1390 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1449
Query: 1566 AERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLS 1625
AE A A Q R Q++ L+ + +QD+ Q + + + ++ E + K
Sbjct: 1450 AEEAEA--QKRQAQEEAERLR------RQVQDESQRKRQAEVELASRVKAEAEAAREK-- 1499
Query: 1626 PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKI 1685
R L AL E QA+E E R+ Q E+E A + ET + A EL +
Sbjct: 1500 QRALQALEELRLQAEE------AERRLRQAEVERARQVQVALETAQRSAEAELQSKR--- 1550
Query: 1686 DALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMM 1745
S QL +L E ++ A L + A +A E+ +++ E
Sbjct: 1551 -------ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1602
Query: 1746 KARHQELLS---QQQNFILATQSAQAFLDQHGHNL--------TPEEQQMLQQKLGELKE 1794
+ + E L Q + AQA ++ EEQ + Q++L E +
Sbjct: 1603 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1662
Query: 1795 QYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSL 1854
+ LA+ A+ Q + EL + + ++ E + E+EL + + E +
Sbjct: 1663 EKQRQLAEGTAQ--QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-----EAAAAT 1715
Query: 1855 LKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYT 1914
KRQ ++ + ++ + S + + S E K +L+ R+
Sbjct: 1716 QKRQ-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---------KQRLEAEAGRFR 1765
Query: 1915 ALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL 1974
L + RL + L + + Q A Q EA E++L++ +A+ + E
Sbjct: 1766 ELAEEAARLRA-----LAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAA----IGEAT 1814
Query: 1975 ATTKQLQEELAEHQVPVEKLQKVARD----IMEIEGEPAPDHRHVQETTDSILSHFQSLS 2030
+ + L E + E+L+++A D +E + A ++E L+ + S
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKAS 1870
Query: 2031 YSLAER-SSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM 2089
S ER L++ + Q + V+E + +L S E+ GK L G I+ +
Sbjct: 1871 DSELERQKGLVEDTLRQRRQVEEEILALKASF---EKAAAGKAELELELGRIRSNAEDTL 1927
Query: 2090 KLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSL 2149
+ +++++ LEA R+ AA + + E +R ++ ++E
Sbjct: 1928 R-----SKEQAELEAARQ----------RQLAAEEERRRREAEERVQKSLAAEEEAARQR 1972
Query: 2150 KKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLD 2209
K L + E + + ++ E + A Q Q+ Q +E QQ+ +
Sbjct: 1973 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2032
Query: 2210 TLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLV 2269
+ L E S L Q + + R+ E ++ + E++A+ + Q++E +L
Sbjct: 2033 LQQTLQQEQSV------LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2086
Query: 2270 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENL 2329
++ + E + + + + E L+ + A++ E+ + +
Sbjct: 2087 QSAE-------------EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2133
Query: 2330 IMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHER 2389
ME ++ T + +++ +++ + L+ E+ +
Sbjct: 2134 EMEKHKKFAE--------------------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2173
Query: 2390 QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAE 2449
E LQ + E ++ + V + L S ++ + + + + E
Sbjct: 2174 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2233
Query: 2450 LEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESA 2509
L++ + K+++V E A L V +QEA +++ EE ++ E + + Q + A
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVA---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2290
Query: 2510 SHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ-KQQVQFMLKEFEARRQQHE 2568
+ L AE++L +KEL L D + Q ++ Q + EA RQ+
Sbjct: 2291 TRL----KAEAELLQ--QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2344
Query: 2569 QLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE 2628
+++ A+ + ++S + ++ +++ Q ++ E+ +KL+ R+ Q
Sbjct: 2345 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELATQ---------- 2393
Query: 2629 LLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDEL 2688
EKV V Q L +Q S ++ E +E+ + E+L E K Q +E+
Sbjct: 2394 ------EKVTLV-QTLEIQRQQSDHD--AERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444
Query: 2689 SVLIGEQYL-------------KDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQ 2735
+ EQ L KD L +R + LE L D + + Q Q+
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2504
Query: 2736 FQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEG 2795
QQ ++ R L + + + E + ++ EE Q+ Q E++ E
Sbjct: 2505 QQQQMEQERQRLVASMEEARRR-----QHEAEEGVRRKQEELQQLEQQRRQQEELLAEEN 2559
Query: 2796 ESLLLSVPPGEEKRTLQNQLVELKNHWEELS 2826
+ L E+ + L+ Q H EE++
Sbjct: 2560 QRL------REQLQLLEEQHRAALAHSEEVT 2584
Score = 131 bits (329), Expect = 2e-29
Identities = 322/1752 (18%), Positives = 693/1752 (39%), Gaps = 241/1752 (13%)
Query: 2635 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE 2694
E R QR++ Q + E + + + S + L A TL EL + +G+
Sbjct: 982 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1041
Query: 2695 ----QYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750
+ L ++L+T++L ++G + A + + + L Q EL
Sbjct: 1042 LEQVRSLSAIYLEKLKTISLVIRGTQG-AEEVLRAHEEQLKEAQAVPATLPELEATKASL 1100
Query: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810
+ +A+ + L+ +L+ +E + L Q G +V E
Sbjct: 1101 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV----------------EVER 1144
Query: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV- 2869
+ ++ +L W+ + +T RQ L+ ++ + Y+ + L W++D + + +++
Sbjct: 1145 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1204
Query: 2870 -TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQN 2928
D + L + +A+L E+E+ +E A IN+ + E + KA + +
Sbjct: 1205 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-EP 1263
Query: 2929 MDAVTEELQAKTGSLEEMTQRLREFQESFKNIE-------KKVEGAKHQLEIFDALGSQA 2981
+ + ++ + ++GS E + Q + + + + K + ++E + L Q
Sbjct: 1264 VASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ- 1321
Query: 2982 CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV 3041
+ E+ EV ALE Q Q + A++E E+
Sbjct: 1322 ---QRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-----------------AEREAKEL 1361
Query: 3042 KQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD-ELDGMGAIGRDTDSLQSQIEDV 3100
+QR+ V E Q ++E QL + E+ + + +IE+
Sbjct: 1362 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1420
Query: 3101 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQ 3160
+I V++L +EA+E + G G + EL+AL + + + + QE+
Sbjct: 1421 -----EIRVVRLQLEATE-------RQRG-----GAEGELQALRARAEEAEAQKRQAQEE 1463
Query: 3161 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPL 3220
E +V+D ++ + + +AEA E + Q L + ++ Q +
Sbjct: 1464 AERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRL----QAEEA 1516
Query: 3221 QMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME-EINARWNTLNKKVAQRIAQLQEALLHC 3279
+ +L+Q +Q A ++ + E E+ ++ + +K AQ LQE +
Sbjct: 1517 ERRLRQAEVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1571
Query: 3280 GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT--VDML 3337
+ ++ E A+ E + AE ++ + Q++ + L+ L + +
Sbjct: 1572 AQLREEAERRAQQQAEAE-----RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1626
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397
QAE + + AE R + G+ E R EL + +Q+QL + A+Q +
Sbjct: 1627 QAEAEKQKEEAEREARRR--GKAEEQAVRQRELAEQELEKQRQLAE--GTAQQRLAAEQE 1682
Query: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKI---GQSLS 3454
+ + TE+ + + + A++Q++ +++E V +++ ++ +
Sbjct: 1683 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1742
Query: 3455 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED----------- 3503
S + +++++ R+ E+ + R AL ++A +L ED
Sbjct: 1743 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1802
Query: 3504 ----------------EVEVLNWLAEVEDKLSSVFVKD--FKQDVLHRQHADHLA-LNEE 3544
E E+ E E++ +D F++ L Q A H A + E
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1862
Query: 3545 IVNRKKNVDQAIKNGQALLKQT------TGEEVLLIQEKLDGIKTRYADITV-------T 3591
+ +K D ++ + L++ T EE+L ++ + A++ +
Sbjct: 1863 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1922
Query: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS-GGQSPTGEQIPQFQQRQKEL 3650
+ LR+ EQA A + + E RE EE + S + Q + + L
Sbjct: 1923 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1982
Query: 3651 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA 3710
K +V E R + + + S L+L A+E K + + + V + +
Sbjct: 1983 KAKVEEARRLRERAEQESARQLQL----AQEAAQKRLQAEEKAHAFA-------VQQKEQ 2031
Query: 3711 AIQRSQQYEQAADAELAWVAETKRKLMALGP---IRLEQDQTTAQLQVQKAFSIDIIRHK 3767
+Q++ Q EQ+ +L AE R+ ++ E++ ++ QV++A R K
Sbjct: 2032 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-----ERLK 2086
Query: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKT------ESLIQQYEA--ISLLNSERYAR--- 3816
S +E R++ + +K QE ++ ++Q +A + +++A
Sbjct: 2087 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146
Query: 3817 LERAQV------LVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 3870
++AQV L Q ET + + EE + L A+ A Q+ ++ +R E
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2206
Query: 3871 SIAEHKPHIDK-----LLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALAL 3925
+++ K I+ +L+ + EE E +++ ++A + +E R R LA
Sbjct: 2207 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA- 2265
Query: 3926 DEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEK 3985
+E ++Q + E + + E ++ + R + AE + +++ + A + +
Sbjct: 2266 EEDLAQQRALAE-----KMLKEKMQAVQEATR----LKAEAELLQQ---QKELAQEQARR 2313
Query: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045
LQ E ++ ++L +QG + L A E Q +L ++ A AE +++ ++
Sbjct: 2314 LQ---EDKEQMAQQLAEETQGFQRTLEA-ERQRQL--------EMSAEAERLKLRVAEMS 2361
Query: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105
+ D ++ + +H E +++V +T++ + + E
Sbjct: 2362 RAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEIQRQQSDHDAER 2415
Query: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER-LEKLEDAMQAAVQYQDTL 4164
+R A+L E EK ++++ + E + +E+ L++ + Q+ + +D+L
Sbjct: 2416 LREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2470
Query: 4165 QAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK 4224
+++ KL + +D++ + ++ + E +QQ +ME+ + ++
Sbjct: 2471 LQRERFIEQEKAKLEQL---------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2521
Query: 4225 KA---TDETDRDIIR--EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4279
+A E + + R E L +L+ E +A +L Q Q E+ +
Sbjct: 2522 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR------EQLQLLEEQHRA 2575
Query: 4280 WLTHTEELLDAQ 4291
L H+EE+ +Q
Sbjct: 2576 ALAHSEEVTASQ 2587
Score = 129 bits (325), Expect = 6e-29
Identities = 545/2630 (20%), Positives = 996/2630 (37%), Gaps = 398/2630 (15%)
Query: 1209 DKNSVFSVLD-EEIAKAKVVAEQ---MSRLTPERNLDLERYQEKG-----SQLQERWHRV 1259
D N V+ + E + +A VAE+ ++RL ++D+ + EK S L + RV
Sbjct: 174 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 233
Query: 1260 I-AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKPGQAEDSRVLSEQLS 1317
Q +R +EL+ + +YR L++W+ TA +E P E+ +L Q
Sbjct: 234 PDVQDGVRANELQLRWQ---EYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 290
Query: 1318 QQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSS 1377
+ + E+ + ++ + Q V+ +L++ PG
Sbjct: 291 KFKEM--ELPAKEADKNRSKGIYQSLEGAVQAGQLKV------------PPGYHP----- 331
Query: 1378 SDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGW 1437
+D+ + L + K + RLE +++V + + E +E L
Sbjct: 332 --------LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME-AGLCEEQLNQ 382
Query: 1438 VSTLARN-----TQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFL 1492
L ++ GK + D++KA ++L ++ T K+
Sbjct: 383 ADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD------------- 429
Query: 1493 AKH--GHKLSEKEKKQISEQLNALNKAYH-DLCDGSANQLQQLQSQLAHQTEQKTLQKQQ 1549
+H G ++ + + + E+L A+ Y+ L G A Q+ +Q+ Q+ Q+ + +
Sbjct: 430 GRHPQGEQMYRRVYR-LHERLVAIRTEYNLRLKAGVAAPATQV-AQVTLQSVQRRPELED 487
Query: 1550 NTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATV 1609
+T + L+DL +WV + + + G + DL +++ + L I+
Sbjct: 488 STL-RYLQDLLAWVEENQHRVDGAEWGV---DLPSVEAQLGSHRGLHQSIEEFRAKIERA 543
Query: 1610 VKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
D + +LSP A R+ L + QY L ++ + LE +
Sbjct: 544 RSD--------EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV----- 590
Query: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729
+ A KEL +K + VG TN+ ++ A + + L
Sbjct: 591 --AAATKELMWLNEKEEE------EVGFDWSDRNTNMTAKKESYSALMRELELKEKK-IK 641
Query: 1730 GVNQAPEKL---DKQCEMMKARHQELLSQQQNFIL-------ATQSAQAFLDQHGHNLTP 1779
+ A ++L D Q L Q +++L A A Q ++
Sbjct: 642 ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 701
Query: 1780 EEQQMLQQKLGE-LKEQYSTSLAQSEAELKQV-QTLQDELQKFLQDHKEFESWLERSEK- 1836
E Q+ QKL E L+ +YS + + L+ + Q QDE ++ L ++K S L + K
Sbjct: 702 AEGQL--QKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ-LNEYKGHLSGLAKRAKA 758
Query: 1837 --ELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQ----KVLDMENSFK 1890
+L+ H LP LL +V HKGD + Q KVL S
Sbjct: 759 VVQLKPRHPAHPMRGRLP-LLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-- 815
Query: 1891 EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950
E PS + LV ++A E T RL + L+ +HQ SL AW Q+
Sbjct: 816 EAAVPS-VCFLVPPPNQEAQEAVT-------RLEAQHQALVTLWHQLHVDMKSLLAW-QS 866
Query: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010
+V+ + S ++A+ T K ++ A H + + Q RD + G
Sbjct: 867 LRRDVQLIRSWSLAT--------FRTLKPEEQRQALHSLELH-YQAFLRDSQDAGGFGPE 917
Query: 2011 DHRHVQETTDSILSHFQSLSYSL---AERSSLLQKAIAQSQSVQESLESL-LQSIGEVEQ 2066
D + S H+Q L SL A+ S Q+ I++ + ++ LE+ +++ +
Sbjct: 918 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 977
Query: 2067 NLEGKQVSSLSSGVI--QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2124
L+ + + + Q+A A L + +AR L A E V E S A L
Sbjct: 978 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR----LSAEAEKVLALPEP--SPAAPTL 1031
Query: 2125 QGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2181
+ +L + EQ L EK ++ ++ + E + ++ ++ + A+
Sbjct: 1032 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT-- 1089
Query: 2182 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---------DLCQHQD 2232
P+ + T +++L + E QQ D L + G L ++ + ++
Sbjct: 1090 LPELEATK--ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1147
Query: 2233 RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSA 2292
RV L + + + R+++ QL +R+ WL++ + A
Sbjct: 1148 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1207
Query: 2293 --KELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME-----ITAPDSQGKTGSI 2345
+ + +Q+ ++LL++ G VEE N I + +T S
Sbjct: 1208 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1267
Query: 2346 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2405
GS + DL +++ + +Y K R E + + + +
Sbjct: 1268 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1327
Query: 2406 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2465
E + ++ K+ L A + K + + + E+ + Q+ K ++
Sbjct: 1328 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387
Query: 2466 GLLVTYPNSQEAENWKKIQE----------------------------------ELNSRW 2491
L S EAE K ++ EL +
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1447
Query: 2492 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 2551
RA E A++RQ +E A L ESQ R E EL V A +
Sbjct: 1448 ARAEEAE-AQKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQA 1505
Query: 2552 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ--VQKELQSINQKWVELTDKL 2609
+ L+ EA R+ + E A+ + V+L T+Q + ELQS + E T +L
Sbjct: 1506 LEELRLQAEEAERRLRQAEVERARQV-----QVALETAQRSAEAELQSKRASFAEKTAQL 1560
Query: 2610 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRS 2669
RS Q + V L++ +E+ RA Q + ++ + E + QL+ +R
Sbjct: 1561 E-RSLQEEHVAVAQ------LREEAER-RAQQQAEAERAREEAERELERWQLKANEALRL 1612
Query: 2670 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK-RLETVALPLQGLEDLAADRINRLQA 2728
L+ EV + ++L + E+ ++ ++ + E A+ + L + ++ +L
Sbjct: 1613 RLQA--EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1670
Query: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQL----QENEEFQKSLNQH 2784
A Q+ + +R + +Q +Q + + +L RLQ + Q+ +E + L +
Sbjct: 1671 GTAQ-QRLAAEQELIRLRAETEQGEQQRQL-LEEELARLQREAAAATQKRQELEAELAKV 1728
Query: 2785 SGSYEVIVA-----EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK-----KTADRQS 2834
EV++A E ES S + K+ L+ + + EE ++ + A RQ
Sbjct: 1729 RAEMEVLLASKARAEEESRSTSE---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1785
Query: 2835 RLKD---CMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVE 2891
+L + Q+A+ + E L E + K +E + L + E+ LR A +
Sbjct: 1786 QLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQ 1844
Query: 2892 KRRSLLEILNSAADI---LINSSEADEDGIRDEKAGINQNMDA---VTEELQAKTGSLEE 2945
+RR + ADI L +A + + +K + + V EE+ A S E+
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1904
Query: 2946 MTQRLREFQESFKNIEKKVEG---AKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
E + I E +K Q E+ A Q + + + A++ V ++L
Sbjct: 1905 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1964
Query: 3003 QVDYLRNFTQGLVEDA---PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG- 3058
+ + R L E +A +L +AE L++ Q + E K
Sbjct: 1965 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2024
Query: 3059 -IGQFHCRVREMFSQLADLDDELDGMGAIGR-------------DTDSLQS--QIEDVRL 3102
+ Q +++ Q + D+L G R + ++ QS Q+E+
Sbjct: 2025 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2084
Query: 3103 FLNKIH------------VLKLDIEASEAECRHMLEEEGTL-DLLGLKRELEALNKQCGK 3149
KL EA + R E+ L E+E +K+ +
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-HKKFAE 2143
Query: 3150 LTERGKARQEQLELTLGRVE----DFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
T R KA+ EQ ELT R++ D + L AE EA + E E+ + +
Sbjct: 2144 QTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2202
Query: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265
+ Q E++ L+ +++ N + LI KD + L+ + E++ K+V
Sbjct: 2203 V------QMEELSKLKARIEAEN---RALILR-DKDNTQRFLQEEAEKM--------KQV 2244
Query: 3266 AQRIAQLQEALLHCGKFQD-ALEPLLSWLADTEELIANQKPPSAEYKVVKAQ---IQEQK 3321
A+ A+L A + + A E L A E+++ + E +KA+ +Q+QK
Sbjct: 2245 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2304
Query: 3322 LL-----QRLLDDRKATVDML--QAEGGRIAQSAELADREKITGQLESLESRWTELLSKA 3374
L +RL +D++ L + +G + AE + +++ + E L+ R E+ S+A
Sbjct: 2305 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRA 2363
Query: 3375 AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKA-- 3431
AR + ED A++F + AE I + L TE LA E V QT +IQ+Q H A
Sbjct: 2364 QARAE--ED----AQRFRKQAEEIGEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAER 2415
Query: 3432 LEE---DIENHATDVHQAVKIGQ------------SLSSLTSPAEQGVLSEKIDSLQARY 3476
L E ++E + Q K+ Q L T +Q LSEK DSL R
Sbjct: 2416 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-DSLLQRE 2474
Query: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEV------------------------------- 3505
I+ + L ++ A+ E++
Sbjct: 2475 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2534
Query: 3506 ----EVLNWLAEVEDKLSSVFVKDFKQ-----DVLHRQHADHLALNEEIVNRKKNVDQAI 3556
E L L + + + ++ ++ +L QH LA +EE+ + + +
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2594
Query: 3557 KNGQALLKQTTGEEVLLIQEKLDGIK-----TRYADITVTSSKALRTLEQ 3601
NG+ L E + DG++ R + + S++ L+ L Q
Sbjct: 2595 PNGRDALDGPAAEAE--PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2642
Score = 100 bits (249), Expect = 4e-20
Identities = 318/1624 (19%), Positives = 619/1624 (38%), Gaps = 261/1624 (16%)
Query: 3221 QMKLQ-QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC 3279
Q K Q +V GLG+G+ + + + V L E + TL ++ + +L++
Sbjct: 994 QQKAQAEVEGLGKGVARLSAEAEKVLALP----EPSPAAPTLRSELELTLGKLEQVRSLS 1049
Query: 3280 GKFQDALEPLLSWLADT---EELIANQKPPSAEYKVVKAQIQEQ-------KLLQRLLDD 3329
+ + L+ + + T EE++ + E + V A + E K L+ +
Sbjct: 1050 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1109
Query: 3330 RKATVDMLQAE-------GGRIAQSAELAD------REKITGQLESLESRWTELLSKAAA 3376
++ T D L+ E G R+ Q D RE++ LE RW +L++
Sbjct: 1110 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE----RWQAVLAQTDV 1165
Query: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKALEED 3435
RQ++LE + + + E+A+P+ +L ++ + + + +++Q+ + +AL E+
Sbjct: 1166 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1225
Query: 3436 IENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495
IE H V + + A+Q + + K LQ + Q A + S
Sbjct: 1226 IERHGEKVEECQRF----------AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1275
Query: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD-Q 3554
+ ++ V++ +E+ L+S ++K + + + + LA + R++ + +
Sbjct: 1276 GSESVIQEYVDLRTHYSEL-TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1334
Query: 3555 AIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 3614
A Q L + + + + ++ R + V +A +Q + +S E
Sbjct: 1335 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK------RSIQE 1388
Query: 3615 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLD-TVNEVSRALLE 3673
EL + E E+ Q+ E + + +++E+ RL L+ T + A E
Sbjct: 1389 ELQQLRQSSEAEIQAKARQAEAAE------RSRLRIEEEIRVVRLQLEATERQRGGAEGE 1442
Query: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----QAADAELAWV 3729
L RAR +A Q + + + ++ QR +Q E AE
Sbjct: 1443 LQALRAR------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1496
Query: 3730 AETKRKLMALGPIRL---EQDQTTAQLQVQKAFSIDI---IRHKDSMDELFSHRSEIFGT 3783
E +R L AL +RL E ++ Q +V++A + + + + EL S R+
Sbjct: 1497 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF--- 1553
Query: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW-IEETR 3842
+KT E+ SL +++ A++ L E R ++ E EL W ++
Sbjct: 1554 ---AEKTAQLER--SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1608
Query: 3843 ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902
AL +L + + ++ Q E +Q E+ E + + +E + E+ E+
Sbjct: 1609 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------GKAEEQAVRQRELAEQ 1660
Query: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962
+ +K Q+ E Q+ LA ++ + + TE ++ +LE E L+ R+
Sbjct: 1661 ELEKQR----QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE--EELA---RLQREA 1711
Query: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4022
A K +E ++ E+E L S K R EE RS + + +
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLAS----KARAEE-ESRSTSEKSKQRLEAEAGRFRE 1766
Query: 4023 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4082
+ ++A AEE + + +LAE+ A + + + L + G + + +
Sbjct: 1767 LAEEAARLRALAEEAKRQ----RQLAEE-----DAARQRAEAERVLAEKLAAIG-EATRL 1816
Query: 4083 KQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT 4142
K + E A KE E E +R L D F E+ + D + L K
Sbjct: 1817 KTEAEIALKEKE------AENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKA 1869
Query: 4143 WKERLEK----LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP-PVGTDLNTVKDQLNE 4197
LE+ +ED ++ Q ++ + A+ + + +G + +D L
Sbjct: 1870 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1929
Query: 4198 MKEFKVEVYQQQ---IEMEKLNHQGELMLKK--ATDETDRDIIREPLTELKHLWENLGE- 4251
++ ++E +Q+ E E+ + E ++K A +E + L E++ L + E
Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989
Query: 4252 -KIAHRQHKLEGALLALGQ-----------------FQHALEELMSWLTHTEELLDAQRP 4293
++ R + L L Q Q +EL L + +LD R
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2049
Query: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN----ELLESSAGDDASSLRSRLE 4349
E E A+ + + QA E E L+ SA + A +
Sbjct: 2050 --------EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2101
Query: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE--------------DFLLELTRMES 4395
A + + Q+ R Q Q+ L+Q Q +E+E ELT +
Sbjct: 2102 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2161
Query: 4396 QLSASKPTGGL------------PETAREQLDTHMELY---------SQLKAKEETYNQL 4434
QL + L E AR++ EL+ S+LKA+ E N+
Sbjct: 2162 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2221
Query: 4435 L---DKGRLMLLSRDDSGSGSKTEQSVALLE------------------QKWHVVSSKME 4473
L DK ++++ + + A L Q+ + ++
Sbjct: 2222 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2281
Query: 4474 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI-----EEHK 4528
E+ ++EA L E + L +Q +A + L Q+ EE +
Sbjct: 2282 EKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2330
Query: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588
F + A R + +E+ +LK + + Q+R E+ QR ++ +
Sbjct: 2331 GFQRTLEAERQRQLEMSAEAERLKLRVAE---------MSRAQARAEEDAQRFRKQAEEI 2381
Query: 4589 DDARKRAKQFHEAWKKLIDWLE--------DAESHLDSELEISNDPDKIKLQ---LSKHK 4637
+ R + + L+ LE DAE ++ E+ + +K++ + L
Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2441
Query: 4638 EFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDS-QKLDNFLGEVRDKWDTVCGKSVERQH 4696
E +T+ +Q + +T +AL++ L +DS + + F+ + + K + + V +
Sbjct: 2442 EEMQTVQQEQLLQET-----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2496
Query: 4697 KLEE 4700
+L E
Sbjct: 2497 QLRE 2500
Score = 67.0 bits (162), Expect = 5e-10
Identities = 235/1255 (18%), Positives = 480/1255 (38%), Gaps = 105/1255 (8%)
Query: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 3922
EE RQ S+ + H L+ PE+ M E +Y + Y Q+ + + Q A
Sbjct: 888 EEQRQALHSL---ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGA 944
Query: 3923 LALDEAVSQSTQITEFHDKIEPMLETLENLS-SRLRMPPLIPAEVDKIREC---ISDNKS 3978
E I+E D I LE E + RLR +P + + REC I++ +
Sbjct: 945 ---QEESRCQRCISELKD-IRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQK 996
Query: 3979 ATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038
A E+E L L E+++ + + AA ++ +L+ + E +++
Sbjct: 997 AQAEVEGLGKGVARLSAEAEKVLALPEPSP---AAPTLRSELELTLGKLEQVRS-LSAIY 1052
Query: 4039 IKFLDVLELAEKFWYDMAALLTT----IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094
++ L + L + +L +K+ Q + L + +K+ AE +
Sbjct: 1053 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1112
Query: 4095 ETDGLHEELEFIRILGADLIFACGE--TEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152
D L +EL + +G L GE E R+ + ++ W+ + R +LE
Sbjct: 1113 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172
Query: 4153 AMQAAVQYQDTLQAMFDWLDNT---VIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQ-- 4207
+ Y+++ + WL + ++ MP D V++QL + + E+ +
Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL--ADSQAVREQLRQEQALLEEIERHG 1230
Query: 4208 ------QQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN---LGEKIAHRQH 4258
Q+ + +N + L+ T + + + P + K + + E + R H
Sbjct: 1231 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1290
Query: 4259 KLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--------LAKHHV 4310
E L Q+ + E + + E L + QR + ++ EVE LA+ H
Sbjct: 1291 YSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHA 1348
Query: 4311 LKNDVLAHQATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4368
+ A + E + E++ E +A D RS E + Q +S + + + +Q
Sbjct: 1349 -QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1407
Query: 4369 LQSTLQQAQGFHSEIEDFLLELTRMESQLSAS----KPTGGLPETAREQLDTHMELYSQL 4424
++ + EI L+L E Q + + E A Q E +L
Sbjct: 1408 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1467
Query: 4425 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA-L 4483
+ + + +Q + + L SR + + + E+ AL Q + + EE + +L +A +
Sbjct: 1468 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEV 1525
Query: 4484 NLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA---NEVNAHRDQ 4540
A + Q +L E AE AS S EEH A E Q
Sbjct: 1526 ERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584
Query: 4541 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI---ERGRSLDDARKRAKQ 4597
E ++ + + ++ + + L + +Q+ E Q+S+ E + ++A + A++
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARR 1643
Query: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH--KEFQKTLGGKQPVYDTTIR 4655
+A ++ + E AE L+ + +++ + +L + + +T G+Q
Sbjct: 1644 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1703
Query: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
R +E + Q+L+ L +VR + + + + EE+ S + L+A
Sbjct: 1704 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAE 1760
Query: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775
++ + A + + Q++L + Q R E
Sbjct: 1761 AGRFRELAEEAAR-----------LRALAEEAKRQRQLAEEDAARQ------RAEAERVL 1803
Query: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF--RDTVHMLLEWLSEAEQT 4833
+ G+ L T + K ++ RL + L + E F R + ++ E+
Sbjct: 1804 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1862
Query: 4834 L-RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKH 4892
L + R A + E + L++ ++VEE+ + + ++ A + +
Sbjct: 1863 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1922
Query: 4893 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIP 4952
+R++ + L A+Q Q E A + + L A + A R ++
Sbjct: 1923 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA------RQRKAAL 1976
Query: 4953 QNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI---EPTHAPFIEKSRSGGRKS 5009
+ ++R+KA + E + E ++ ++ + +K + E HA +++ +++
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2036
Query: 5010 LSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064
L Q + ++EA + Q A + +R++ +A +RL++ E
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAE 2090
Score = 39.7 bits (91), Expect = 0.082
Identities = 26/54 (48%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 5350 SASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRR 5403
S S GS AGSR GSR SR GS FD T S S T SS+ G RR
Sbjct: 4447 SVSGSGSTAGSRTGSRTGSRAGSRRGSFD--ATGSGFSMTFSSSSYSSSGYGRR 4498
Score = 34.3 bits (77), Expect = 3.5
Identities = 49/247 (19%), Positives = 98/247 (39%), Gaps = 25/247 (10%)
Query: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635
+V +S++R L+D+ R Q L+ W+E+ + +D E D ++ QL
Sbjct: 473 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 525
Query: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEK-TLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
H+ G Q + + + RA ++ L P + LG + ++ + S R
Sbjct: 526 HR------GLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 579
Query: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLM---DAHKVFQK 4751
LE F+ A + WL + E E++ D N+ +++ +
Sbjct: 580 LRSLESL----HSFVAAATKELMWLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMR 631
Query: 4752 ELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALK 4811
EL + ++ L+ +G L+ V+ L T+W + +L ++ L++
Sbjct: 632 ELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAA 691
Query: 4812 QAEVFRD 4818
+ F D
Sbjct: 692 YFQFFSD 698
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 1379 bits (3569), Expect = 0.0
Identities = 924/2804 (32%), Positives = 1489/2804 (53%), Gaps = 249/2804 (8%)
Query: 62 LDPA---ERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEV 118
+DP+ + + + DERDRVQKKTFTKWVNKHL+K ++HI+DLYEDLRDGHNLISLLEV
Sbjct: 1 MDPSRAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 60
Query: 119 LSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIIL 178
LSG LPREKGRMRFH+LQNVQIALD+L+ RQVKLVNIRNDDI DGNPKLTLGLIWTIIL
Sbjct: 61 LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 120
Query: 179 HFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRP 238
HFQISDI +SG+S DM+AKEKLLLW+Q++ GY G++C NF+S W DG++FNA+IHR++P
Sbjct: 121 HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 180
Query: 239 DLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAF 297
L+DM +V Q+N ENL+QAF VAER LGVTRLLD EDVDVP PDEKS+ITYVSS+YDA
Sbjct: 181 LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 240
Query: 298 PKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYI 357
P+VP+ +G+ A E+ RWQEY+ V L+ W++ HT ++ FP + E++ L++Q++
Sbjct: 241 PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 300
Query: 358 HFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREK 417
FKE E+ AKE +K R + +Y+ LE ++ G++K+P GYHP DVE+EWGKL + +LEREK
Sbjct: 301 KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 360
Query: 418 SLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYI 477
LR ERLE L +I K+Q A CEE+L A LQ+D L +G+ Q +V +
Sbjct: 361 QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 420
Query: 478 QECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLEL 537
+ + +IR L D+Q L+D + Q E++ RV RL + LV +R E + G
Sbjct: 421 DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG------- 473
Query: 538 VPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVE 597
A P T+ + S R+P EL ++ LR++ +LL+WVE
Sbjct: 474 -----------VAAPATQVAQVTLQSVQRRP----EL-------EDSTLRYLQDLLAWVE 511
Query: 598 EMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAET 657
E Q +++ AEWG DLPSVE QL + + +H S+EE + ++ AR EG++S +Y +
Sbjct: 512 ENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDC 571
Query: 658 LGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISA 717
LG+L+ QY KL +S R+R L+SLH FV+ AT EL+WLNEKEEEE+ +DWSD N+N++A
Sbjct: 572 LGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTA 631
Query: 718 KRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLC 777
K+ +S L ELE K+ + LQ+ + L E+HPA+ TVE++ AA+Q+Q WM QLC C
Sbjct: 632 KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCC 691
Query: 778 VEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQ 837
+E H+KEN AYFQFFSD RE E L+ LQ++++RKYSCD + +++RLEDLLQD+ DEKEQ
Sbjct: 692 IEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ 751
Query: 838 LIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDN 897
L + K ++ L R+K +VQLKPR P H ++ + + AVCDY+Q+E+T+ K DEC L
Sbjct: 752 LNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGP 811
Query: 898 SQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSL 957
+Q + WKV+S +G+EA VPSVCFL+PPPN++A E +R+E +Q ++ LWHQLHV+ KSL
Sbjct: 812 AQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSL 871
Query: 958 ISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLR 1017
++W LR+D+ L+++W+L R+ P E Q + +L+ HY+ FL+DS+D+ F DRL
Sbjct: 872 LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 931
Query: 1018 LEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASS 1077
E E +C +Q L++S+E +EE+ + ISELK+IRL+LE E R V R++
Sbjct: 932 AEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR----L 987
Query: 1078 RTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNL 1137
D++ ++ A RIAEQ+ Q +++ L + +S + + L S + PTLRSEL L
Sbjct: 988 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1047
Query: 1138 LVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHW 1197
+ K++ V LS +YL KLKT+ +++R Q AE +++ +E +L + + V A L LEA
Sbjct: 1048 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1107
Query: 1198 STLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWH 1257
++L+ + + + F L +E+ A+ V E++ + ER++++ER++E+ +QL ERW
Sbjct: 1108 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1167
Query: 1258 RVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLS 1317
V+AQ ++RQ ELE + L YR L W+++ +QE ++ DS+ + EQL
Sbjct: 1168 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1227
Query: 1318 QQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSS 1377
Q+ AL EIER+ K+++CQ+F++QY +KDYELQL+TYKA +E SP K+ ++ S
Sbjct: 1228 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPAKKPKVQSG 1286
Query: 1378 SDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGW 1437
S+++ QE++DLRT Y+ L TLT+Q++K+IS+ LRR+EEEE++ E+++ E E++ E+
Sbjct: 1287 SESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV--- 1343
Query: 1438 VSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGH 1497
+ L + Q ++ K + E L+Q+ + EE+ ++E +A
Sbjct: 1344 EAALEKQRQLAEAHAQAKAQAEREAKELQQR-MQEEVVRREEAAVDA------------- 1389
Query: 1498 KLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQ-SQLAHQTEQKTLQKQQNTCHQQL 1556
+++K+ I E+L L ++ A Q + + S+L + E + ++ Q +Q
Sbjct: 1390 ---QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1446
Query: 1557 ----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKD 1612
+L + +AE A A Q R Q++ L+ + +QD+ Q + + +
Sbjct: 1447 GGAEGELQALRARAEEAEA--QKRQAQEEAERLR------RQVQDESQRKRQAEVELASR 1498
Query: 1613 IEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKS 1672
++ E + K R L AL E QA+E E R+ Q E+E A + ET +
Sbjct: 1499 VKAEAEAAREK--QRALQALEELRLQAEE------AERRLRQAEVERARQVQVALETAQR 1550
Query: 1673 KAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVN 1732
A EL + S QL +L E ++ A L + A
Sbjct: 1551 SAEAELQSKR----------ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAE 1599
Query: 1733 QAPEKLDKQCEMMKARHQELLS---QQQNFILATQSAQAFLDQHGHNL--------TPEE 1781
+A E+ +++ E + + E L Q + AQA ++ EE
Sbjct: 1600 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1659
Query: 1782 QQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENM 1841
Q + Q++L E + + LA+ A+ Q + EL + + ++ E + E+EL +
Sbjct: 1660 QAVRQRELAEQELEKQRQLAEGTAQ--QRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1717
Query: 1842 HKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNL 1901
+ E + KRQ ++ + ++ + S + + S E
Sbjct: 1718 QR-----EAAAATQKRQ-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS-------- 1763
Query: 1902 VKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSD 1961
K +L+ R+ L + RL + L + + Q A Q EA E++L++
Sbjct: 1764 -KQRLEAEAGRFRELAEEAARLRA-----LAEEAKRQRQLAEEDAARQRAEA--ERVLAE 1815
Query: 1962 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARD----IMEIEGEPAPDHRHVQE 2017
+A+ + E + + L E + E+L+++A D +E + A ++E
Sbjct: 1816 KLAA----IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1871
Query: 2018 TTDSILSHFQSLSYSLAER-SSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSL 2076
L+ + S S ER L++ + Q + V+E + +L S E+ GK L
Sbjct: 1872 R----LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF---EKAAAGKAELEL 1924
Query: 2077 SSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFE 2136
G I+ ++ +++++ LEA R+ AA + + E +R +
Sbjct: 1925 ELGRIRSNAEDTLR-----SKEQAELEAARQ----------RQLAAEEERRRREAEERVQ 1969
Query: 2137 QLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQE 2196
+ ++E K L + E + + ++ E + A Q Q+ Q +E
Sbjct: 1970 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029
Query: 2197 LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDAS 2256
QQ+ + + L E S L Q + + R+ E ++ + E++A+
Sbjct: 2030 KAHAFAVQQKEQELQQTLQQEQSV------LDQLRGEAEAARRAAEEAEEARVQAEREAA 2083
Query: 2257 SCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLV 2316
+ Q++E +L ++ + E + + + + E L+ + A++
Sbjct: 2084 QSRRQVEEAERLKQSAE-------------EQAQARAQAQAAAEKLRKEAEQEAARRAQA 2130
Query: 2317 EEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVN 2376
E+ + + ME ++ T + +++ +++ +
Sbjct: 2131 EQAALRQKQAADAEMEKHKKFAE--------------------QTLRQKAQVEQELTTLR 2170
Query: 2377 LKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETV 2436
L+ E+ + E LQ + E ++ + V + L S ++ + + + + E
Sbjct: 2171 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2230
Query: 2437 KAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATE 2496
L++ + K+++V E A L V +QEA +++ EE ++ E
Sbjct: 2231 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLRQLAEEDLAQQRALAE 2287
Query: 2497 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ-KQQVQF 2555
+ + Q + A+ L AE++L +KEL L D + Q ++ Q
Sbjct: 2288 KMLKEKMQAVQEATRL----KAEAELLQ--QQKELAQEQARRLQEDKEQMAQQLAEETQG 2341
Query: 2556 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 2615
+ EA RQ+ +++ A+ + ++S + ++ +++ Q ++ E+ +KL+ R+
Sbjct: 2342 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTEL 2400
Query: 2616 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLD 2675
Q EKV V Q L +Q S ++ E +E+ + E+L
Sbjct: 2401 ATQ----------------EKVTLV-QTLEIQRQQSDHD--AERLREAIAELEREKEKLQ 2441
Query: 2676 HEVKEAQTLCDELSVLIGEQYL-------------KDELKKRLETVALPLQGLEDLAADR 2722
E K Q +E+ + EQ L KD L +R + LE L D
Sbjct: 2442 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2501
Query: 2723 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 2782
+ + Q Q+ QQ ++ R L + + + E + ++ EE Q+
Sbjct: 2502 VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR-----QHEAEEGVRRKQEELQQLEQ 2556
Query: 2783 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS 2826
Q E++ E + L E+ + L+ Q H EE++
Sbjct: 2557 QRRQQEELLAEENQRL------REQLQLLEEQHRAALAHSEEVT 2594
Score = 131 bits (329), Expect = 2e-29
Identities = 322/1752 (18%), Positives = 693/1752 (39%), Gaps = 241/1752 (13%)
Query: 2635 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE 2694
E R QR++ Q + E + + + S + L A TL EL + +G+
Sbjct: 992 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1051
Query: 2695 ----QYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750
+ L ++L+T++L ++G + A + + + L Q EL
Sbjct: 1052 LEQVRSLSAIYLEKLKTISLVIRGTQG-AEEVLRAHEEQLKEAQAVPATLPELEATKASL 1110
Query: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810
+ +A+ + L+ +L+ +E + L Q G +V E
Sbjct: 1111 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV----------------EVER 1154
Query: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV- 2869
+ ++ +L W+ + +T RQ L+ ++ + Y+ + L W++D + + +++
Sbjct: 1155 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1214
Query: 2870 -TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQN 2928
D + L + +A+L E+E+ +E A IN+ + E + KA + +
Sbjct: 1215 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-EP 1273
Query: 2929 MDAVTEELQAKTGSLEEMTQRLREFQESFKNIE-------KKVEGAKHQLEIFDALGSQA 2981
+ + ++ + ++GS E + Q + + + + K + ++E + L Q
Sbjct: 1274 VASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ- 1331
Query: 2982 CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV 3041
+ E+ EV ALE Q Q + A++E E+
Sbjct: 1332 ---QRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-----------------AEREAKEL 1371
Query: 3042 KQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD-ELDGMGAIGRDTDSLQSQIEDV 3100
+QR+ V E Q ++E QL + E+ + + +IE+
Sbjct: 1372 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1430
Query: 3101 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQ 3160
+I V++L +EA+E + G G + EL+AL + + + + QE+
Sbjct: 1431 -----EIRVVRLQLEATE-------RQRG-----GAEGELQALRARAEEAEAQKRQAQEE 1473
Query: 3161 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPL 3220
E +V+D ++ + + +AEA E + Q L + ++ Q +
Sbjct: 1474 AERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRL----QAEEA 1526
Query: 3221 QMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME-EINARWNTLNKKVAQRIAQLQEALLHC 3279
+ +L+Q +Q A ++ + E E+ ++ + +K AQ LQE +
Sbjct: 1527 ERRLRQAEVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1581
Query: 3280 GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT--VDML 3337
+ ++ E A+ E + AE ++ + Q++ + L+ L + +
Sbjct: 1582 AQLREEAERRAQQQAEAE-----RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397
QAE + + AE R + G+ E R EL + +Q+QL + A+Q +
Sbjct: 1637 QAEAEKQKEEAEREARRR--GKAEEQAVRQRELAEQELEKQRQLAE--GTAQQRLAAEQE 1692
Query: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKI---GQSLS 3454
+ + TE+ + + + A++Q++ +++E V +++ ++ +
Sbjct: 1693 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1752
Query: 3455 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED----------- 3503
S + +++++ R+ E+ + R AL ++A +L ED
Sbjct: 1753 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1812
Query: 3504 ----------------EVEVLNWLAEVEDKLSSVFVKD--FKQDVLHRQHADHLA-LNEE 3544
E E+ E E++ +D F++ L Q A H A + E
Sbjct: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1872
Query: 3545 IVNRKKNVDQAIKNGQALLKQT------TGEEVLLIQEKLDGIKTRYADITV-------T 3591
+ +K D ++ + L++ T EE+L ++ + A++ +
Sbjct: 1873 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1932
Query: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS-GGQSPTGEQIPQFQQRQKEL 3650
+ LR+ EQA A + + E RE EE + S + Q + + L
Sbjct: 1933 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1992
Query: 3651 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA 3710
K +V E R + + + S L+L A+E K + + + V + +
Sbjct: 1993 KAKVEEARRLRERAEQESARQLQL----AQEAAQKRLQAEEKAHAFA-------VQQKEQ 2041
Query: 3711 AIQRSQQYEQAADAELAWVAETKRKLMALGP---IRLEQDQTTAQLQVQKAFSIDIIRHK 3767
+Q++ Q EQ+ +L AE R+ ++ E++ ++ QV++A R K
Sbjct: 2042 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-----ERLK 2096
Query: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKT------ESLIQQYEA--ISLLNSERYAR--- 3816
S +E R++ + +K QE ++ ++Q +A + +++A
Sbjct: 2097 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156
Query: 3817 LERAQV------LVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 3870
++AQV L Q ET + + EE + L A+ A Q+ ++ +R E
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2216
Query: 3871 SIAEHKPHIDK-----LLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALAL 3925
+++ K I+ +L+ + EE E +++ ++A + +E R R LA
Sbjct: 2217 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA- 2275
Query: 3926 DEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEK 3985
+E ++Q + E + + E ++ + R + AE + +++ + A + +
Sbjct: 2276 EEDLAQQRALAE-----KMLKEKMQAVQEATR----LKAEAELLQQ---QKELAQEQARR 2323
Query: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045
LQ E ++ ++L +QG + L A E Q +L ++ A AE +++ ++
Sbjct: 2324 LQ---EDKEQMAQQLAEETQGFQRTLEA-ERQRQL--------EMSAEAERLKLRVAEMS 2371
Query: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105
+ D ++ + +H E +++V +T++ + + E
Sbjct: 2372 RAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEIQRQQSDHDAER 2425
Query: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER-LEKLEDAMQAAVQYQDTL 4164
+R A+L E EK ++++ + E + +E+ L++ + Q+ + +D+L
Sbjct: 2426 LREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2480
Query: 4165 QAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK 4224
+++ KL + +D++ + ++ + E +QQ +ME+ + ++
Sbjct: 2481 LQRERFIEQEKAKLEQL---------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2531
Query: 4225 KA---TDETDRDIIR--EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4279
+A E + + R E L +L+ E +A +L Q Q E+ +
Sbjct: 2532 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR------EQLQLLEEQHRA 2585
Query: 4280 WLTHTEELLDAQ 4291
L H+EE+ +Q
Sbjct: 2586 ALAHSEEVTASQ 2597
Score = 129 bits (325), Expect = 6e-29
Identities = 545/2630 (20%), Positives = 996/2630 (37%), Gaps = 398/2630 (15%)
Query: 1209 DKNSVFSVLD-EEIAKAKVVAEQ---MSRLTPERNLDLERYQEKG-----SQLQERWHRV 1259
D N V+ + E + +A VAE+ ++RL ++D+ + EK S L + RV
Sbjct: 184 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 243
Query: 1260 I-AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKPGQAEDSRVLSEQLS 1317
Q +R +EL+ + +YR L++W+ TA +E P E+ +L Q
Sbjct: 244 PDVQDGVRANELQLRWQ---EYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 300
Query: 1318 QQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSS 1377
+ + E+ + ++ + Q V+ +L++ PG
Sbjct: 301 KFKEM--ELPAKEADKNRSKGIYQSLEGAVQAGQLKV------------PPGYHP----- 341
Query: 1378 SDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGW 1437
+D+ + L + K + RLE +++V + + E +E L
Sbjct: 342 --------LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME-AGLCEEQLNQ 392
Query: 1438 VSTLARN-----TQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFL 1492
L ++ GK + D++KA ++L ++ T K+
Sbjct: 393 ADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD------------- 439
Query: 1493 AKH--GHKLSEKEKKQISEQLNALNKAYH-DLCDGSANQLQQLQSQLAHQTEQKTLQKQQ 1549
+H G ++ + + + E+L A+ Y+ L G A Q+ +Q+ Q+ Q+ + +
Sbjct: 440 GRHPQGEQMYRRVYR-LHERLVAIRTEYNLRLKAGVAAPATQV-AQVTLQSVQRRPELED 497
Query: 1550 NTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATV 1609
+T + L+DL +WV + + + G + DL +++ + L I+
Sbjct: 498 STL-RYLQDLLAWVEENQHRVDGAEWGV---DLPSVEAQLGSHRGLHQSIEEFRAKIERA 553
Query: 1610 VKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
D + +LSP A R+ L + QY L ++ + LE +
Sbjct: 554 RSD--------EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV----- 600
Query: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729
+ A KEL +K + VG TN+ ++ A + + L
Sbjct: 601 --AAATKELMWLNEKEEE------EVGFDWSDRNTNMTAKKESYSALMRELELKEKK-IK 651
Query: 1730 GVNQAPEKL---DKQCEMMKARHQELLSQQQNFIL-------ATQSAQAFLDQHGHNLTP 1779
+ A ++L D Q L Q +++L A A Q ++
Sbjct: 652 ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 711
Query: 1780 EEQQMLQQKLGE-LKEQYSTSLAQSEAELKQV-QTLQDELQKFLQDHKEFESWLERSEK- 1836
E Q+ QKL E L+ +YS + + L+ + Q QDE ++ L ++K S L + K
Sbjct: 712 AEGQL--QKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ-LNEYKGHLSGLAKRAKA 768
Query: 1837 --ELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQ----KVLDMENSFK 1890
+L+ H LP LL +V HKGD + Q KVL S
Sbjct: 769 VVQLKPRHPAHPMRGRLP-LLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-- 825
Query: 1891 EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950
E PS + LV ++A E T RL + L+ +HQ SL AW Q+
Sbjct: 826 EAAVPS-VCFLVPPPNQEAQEAVT-------RLEAQHQALVTLWHQLHVDMKSLLAW-QS 876
Query: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010
+V+ + S ++A+ T K ++ A H + + Q RD + G
Sbjct: 877 LRRDVQLIRSWSLAT--------FRTLKPEEQRQALHSLELH-YQAFLRDSQDAGGFGPE 927
Query: 2011 DHRHVQETTDSILSHFQSLSYSL---AERSSLLQKAIAQSQSVQESLESL-LQSIGEVEQ 2066
D + S H+Q L SL A+ S Q+ I++ + ++ LE+ +++ +
Sbjct: 928 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 987
Query: 2067 NLEGKQVSSLSSGVI--QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2124
L+ + + + Q+A A L + +AR L A E V E S A L
Sbjct: 988 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR----LSAEAEKVLALPEP--SPAAPTL 1041
Query: 2125 QGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2181
+ +L + EQ L EK ++ ++ + E + ++ ++ + A+
Sbjct: 1042 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT-- 1099
Query: 2182 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---------DLCQHQD 2232
P+ + T +++L + E QQ D L + G L ++ + ++
Sbjct: 1100 LPELEATK--ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1157
Query: 2233 RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSA 2292
RV L + + + R+++ QL +R+ WL++ + A
Sbjct: 1158 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1217
Query: 2293 --KELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME-----ITAPDSQGKTGSI 2345
+ + +Q+ ++LL++ G VEE N I + +T S
Sbjct: 1218 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1277
Query: 2346 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2405
GS + DL +++ + +Y K R E + + + +
Sbjct: 1278 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1337
Query: 2406 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2465
E + ++ K+ L A + K + + + E+ + Q+ K ++
Sbjct: 1338 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397
Query: 2466 GLLVTYPNSQEAENWKKIQE----------------------------------ELNSRW 2491
L S EAE K ++ EL +
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1457
Query: 2492 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 2551
RA E A++RQ +E A L ESQ R E EL V A +
Sbjct: 1458 ARAEEAE-AQKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQA 1515
Query: 2552 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ--VQKELQSINQKWVELTDKL 2609
+ L+ EA R+ + E A+ + V+L T+Q + ELQS + E T +L
Sbjct: 1516 LEELRLQAEEAERRLRQAEVERARQV-----QVALETAQRSAEAELQSKRASFAEKTAQL 1570
Query: 2610 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRS 2669
RS Q + V L++ +E+ RA Q + ++ + E + QL+ +R
Sbjct: 1571 E-RSLQEEHVAVAQ------LREEAER-RAQQQAEAERAREEAERELERWQLKANEALRL 1622
Query: 2670 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK-RLETVALPLQGLEDLAADRINRLQA 2728
L+ EV + ++L + E+ ++ ++ + E A+ + L + ++ +L
Sbjct: 1623 RLQA--EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1680
Query: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQL----QENEEFQKSLNQH 2784
A Q+ + +R + +Q +Q + + +L RLQ + Q+ +E + L +
Sbjct: 1681 GTAQ-QRLAAEQELIRLRAETEQGEQQRQL-LEEELARLQREAAAATQKRQELEAELAKV 1738
Query: 2785 SGSYEVIVA-----EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK-----KTADRQS 2834
EV++A E ES S + K+ L+ + + EE ++ + A RQ
Sbjct: 1739 RAEMEVLLASKARAEEESRSTSE---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1795
Query: 2835 RLKD---CMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVE 2891
+L + Q+A+ + E L E + K +E + L + E+ LR A +
Sbjct: 1796 QLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQ 1854
Query: 2892 KRRSLLEILNSAADI---LINSSEADEDGIRDEKAGINQNMDA---VTEELQAKTGSLEE 2945
+RR + ADI L +A + + +K + + V EE+ A S E+
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1914
Query: 2946 MTQRLREFQESFKNIEKKVEG---AKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
E + I E +K Q E+ A Q + + + A++ V ++L
Sbjct: 1915 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974
Query: 3003 QVDYLRNFTQGLVEDA---PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG- 3058
+ + R L E +A +L +AE L++ Q + E K
Sbjct: 1975 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2034
Query: 3059 -IGQFHCRVREMFSQLADLDDELDGMGAIGR-------------DTDSLQS--QIEDVRL 3102
+ Q +++ Q + D+L G R + ++ QS Q+E+
Sbjct: 2035 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2094
Query: 3103 FLNKIH------------VLKLDIEASEAECRHMLEEEGTL-DLLGLKRELEALNKQCGK 3149
KL EA + R E+ L E+E +K+ +
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-HKKFAE 2153
Query: 3150 LTERGKARQEQLELTLGRVE----DFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
T R KA+ EQ ELT R++ D + L AE EA + E E+ + +
Sbjct: 2154 QTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212
Query: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265
+ Q E++ L+ +++ N + LI KD + L+ + E++ K+V
Sbjct: 2213 V------QMEELSKLKARIEAEN---RALILR-DKDNTQRFLQEEAEKM--------KQV 2254
Query: 3266 AQRIAQLQEALLHCGKFQD-ALEPLLSWLADTEELIANQKPPSAEYKVVKAQ---IQEQK 3321
A+ A+L A + + A E L A E+++ + E +KA+ +Q+QK
Sbjct: 2255 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2314
Query: 3322 LL-----QRLLDDRKATVDML--QAEGGRIAQSAELADREKITGQLESLESRWTELLSKA 3374
L +RL +D++ L + +G + AE + +++ + E L+ R E+ S+A
Sbjct: 2315 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRA 2373
Query: 3375 AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKA-- 3431
AR + ED A++F + AE I + L TE LA E V QT +IQ+Q H A
Sbjct: 2374 QARAE--ED----AQRFRKQAEEIGEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAER 2425
Query: 3432 LEE---DIENHATDVHQAVKIGQ------------SLSSLTSPAEQGVLSEKIDSLQARY 3476
L E ++E + Q K+ Q L T +Q LSEK DSL R
Sbjct: 2426 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-DSLLQRE 2484
Query: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEV------------------------------- 3505
I+ + L ++ A+ E++
Sbjct: 2485 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2544
Query: 3506 ----EVLNWLAEVEDKLSSVFVKDFKQ-----DVLHRQHADHLALNEEIVNRKKNVDQAI 3556
E L L + + + ++ ++ +L QH LA +EE+ + + +
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2604
Query: 3557 KNGQALLKQTTGEEVLLIQEKLDGIK-----TRYADITVTSSKALRTLEQ 3601
NG+ L E + DG++ R + + S++ L+ L Q
Sbjct: 2605 PNGRDALDGPAAEAE--PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2652
Score = 100 bits (249), Expect = 4e-20
Identities = 318/1624 (19%), Positives = 619/1624 (38%), Gaps = 261/1624 (16%)
Query: 3221 QMKLQ-QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC 3279
Q K Q +V GLG+G+ + + + V L E + TL ++ + +L++
Sbjct: 1004 QQKAQAEVEGLGKGVARLSAEAEKVLALP----EPSPAAPTLRSELELTLGKLEQVRSLS 1059
Query: 3280 GKFQDALEPLLSWLADT---EELIANQKPPSAEYKVVKAQIQEQ-------KLLQRLLDD 3329
+ + L+ + + T EE++ + E + V A + E K L+ +
Sbjct: 1060 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1119
Query: 3330 RKATVDMLQAE-------GGRIAQSAELAD------REKITGQLESLESRWTELLSKAAA 3376
++ T D L+ E G R+ Q D RE++ LE RW +L++
Sbjct: 1120 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE----RWQAVLAQTDV 1175
Query: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKALEED 3435
RQ++LE + + + E+A+P+ +L ++ + + + +++Q+ + +AL E+
Sbjct: 1176 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1235
Query: 3436 IENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495
IE H V + + A+Q + + K LQ + Q A + S
Sbjct: 1236 IERHGEKVEECQRF----------AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1285
Query: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD-Q 3554
+ ++ V++ +E+ L+S ++K + + + + LA + R++ + +
Sbjct: 1286 GSESVIQEYVDLRTHYSEL-TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344
Query: 3555 AIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 3614
A Q L + + + + ++ R + V +A +Q + +S E
Sbjct: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK------RSIQE 1398
Query: 3615 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLD-TVNEVSRALLE 3673
EL + E E+ Q+ E + + +++E+ RL L+ T + A E
Sbjct: 1399 ELQQLRQSSEAEIQAKARQAEAAE------RSRLRIEEEIRVVRLQLEATERQRGGAEGE 1452
Query: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----QAADAELAWV 3729
L RAR +A Q + + + ++ QR +Q E AE
Sbjct: 1453 LQALRAR------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1506
Query: 3730 AETKRKLMALGPIRL---EQDQTTAQLQVQKAFSIDI---IRHKDSMDELFSHRSEIFGT 3783
E +R L AL +RL E ++ Q +V++A + + + + EL S R+
Sbjct: 1507 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF--- 1563
Query: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW-IEETR 3842
+KT E+ SL +++ A++ L E R ++ E EL W ++
Sbjct: 1564 ---AEKTAQLER--SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1618
Query: 3843 ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902
AL +L + + ++ Q E +Q E+ E + + +E + E+ E+
Sbjct: 1619 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------GKAEEQAVRQRELAEQ 1670
Query: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962
+ +K Q+ E Q+ LA ++ + + TE ++ +LE E L+ R+
Sbjct: 1671 ELEKQR----QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE--EELA---RLQREA 1721
Query: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4022
A K +E ++ E+E L S K R EE RS + + +
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLAS----KARAEE-ESRSTSEKSKQRLEAEAGRFRE 1776
Query: 4023 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4082
+ ++A AEE + + +LAE+ A + + + L + G + + +
Sbjct: 1777 LAEEAARLRALAEEAKRQ----RQLAEE-----DAARQRAEAERVLAEKLAAIG-EATRL 1826
Query: 4083 KQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT 4142
K + E A KE E E +R L D F E+ + D + L K
Sbjct: 1827 KTEAEIALKEKE------AENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKA 1879
Query: 4143 WKERLEK----LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP-PVGTDLNTVKDQLNE 4197
LE+ +ED ++ Q ++ + A+ + + +G + +D L
Sbjct: 1880 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1939
Query: 4198 MKEFKVEVYQQQ---IEMEKLNHQGELMLKK--ATDETDRDIIREPLTELKHLWENLGE- 4251
++ ++E +Q+ E E+ + E ++K A +E + L E++ L + E
Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999
Query: 4252 -KIAHRQHKLEGALLALGQ-----------------FQHALEELMSWLTHTEELLDAQRP 4293
++ R + L L Q Q +EL L + +LD R
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2059
Query: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN----ELLESSAGDDASSLRSRLE 4349
E E A+ + + QA E E L+ SA + A +
Sbjct: 2060 --------EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2111
Query: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE--------------DFLLELTRMES 4395
A + + Q+ R Q Q+ L+Q Q +E+E ELT +
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2171
Query: 4396 QLSASKPTGGL------------PETAREQLDTHMELY---------SQLKAKEETYNQL 4434
QL + L E AR++ EL+ S+LKA+ E N+
Sbjct: 2172 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2231
Query: 4435 L---DKGRLMLLSRDDSGSGSKTEQSVALLE------------------QKWHVVSSKME 4473
L DK ++++ + + A L Q+ + ++
Sbjct: 2232 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2291
Query: 4474 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI-----EEHK 4528
E+ ++EA L E + L +Q +A + L Q+ EE +
Sbjct: 2292 EKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340
Query: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588
F + A R + +E+ +LK + + Q+R E+ QR ++ +
Sbjct: 2341 GFQRTLEAERQRQLEMSAEAERLKLRVAE---------MSRAQARAEEDAQRFRKQAEEI 2391
Query: 4589 DDARKRAKQFHEAWKKLIDWLE--------DAESHLDSELEISNDPDKIKLQ---LSKHK 4637
+ R + + L+ LE DAE ++ E+ + +K++ + L
Sbjct: 2392 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2451
Query: 4638 EFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDS-QKLDNFLGEVRDKWDTVCGKSVERQH 4696
E +T+ +Q + +T +AL++ L +DS + + F+ + + K + + V +
Sbjct: 2452 EEMQTVQQEQLLQET-----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2506
Query: 4697 KLEE 4700
+L E
Sbjct: 2507 QLRE 2510
Score = 67.0 bits (162), Expect = 5e-10
Identities = 235/1255 (18%), Positives = 480/1255 (38%), Gaps = 105/1255 (8%)
Query: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 3922
EE RQ S+ + H L+ PE+ M E +Y + Y Q+ + + Q A
Sbjct: 898 EEQRQALHSL---ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGA 954
Query: 3923 LALDEAVSQSTQITEFHDKIEPMLETLENLS-SRLRMPPLIPAEVDKIREC---ISDNKS 3978
E I+E D I LE E + RLR +P + + REC I++ +
Sbjct: 955 ---QEESRCQRCISELKD-IRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQK 1006
Query: 3979 ATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038
A E+E L L E+++ + + AA ++ +L+ + E +++
Sbjct: 1007 AQAEVEGLGKGVARLSAEAEKVLALPEPSP---AAPTLRSELELTLGKLEQVRS-LSAIY 1062
Query: 4039 IKFLDVLELAEKFWYDMAALLTT----IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094
++ L + L + +L +K+ Q + L + +K+ AE +
Sbjct: 1063 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1122
Query: 4095 ETDGLHEELEFIRILGADLIFACGE--TEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152
D L +EL + +G L GE E R+ + ++ W+ + R +LE
Sbjct: 1123 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182
Query: 4153 AMQAAVQYQDTLQAMFDWLDNT---VIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQ-- 4207
+ Y+++ + WL + ++ MP D V++QL + + E+ +
Sbjct: 1183 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL--ADSQAVREQLRQEQALLEEIERHG 1240
Query: 4208 ------QQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN---LGEKIAHRQH 4258
Q+ + +N + L+ T + + + P + K + + E + R H
Sbjct: 1241 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1300
Query: 4259 KLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--------LAKHHV 4310
E L Q+ + E + + E L + QR + ++ EVE LA+ H
Sbjct: 1301 YSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHA 1358
Query: 4311 LKNDVLAHQATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4368
+ A + E + E++ E +A D RS E + Q +S + + + +Q
Sbjct: 1359 -QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1417
Query: 4369 LQSTLQQAQGFHSEIEDFLLELTRMESQLSAS----KPTGGLPETAREQLDTHMELYSQL 4424
++ + EI L+L E Q + + E A Q E +L
Sbjct: 1418 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1477
Query: 4425 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA-L 4483
+ + + +Q + + L SR + + + E+ AL Q + + EE + +L +A +
Sbjct: 1478 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEV 1535
Query: 4484 NLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA---NEVNAHRDQ 4540
A + Q +L E AE AS S EEH A E Q
Sbjct: 1536 ERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594
Query: 4541 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI---ERGRSLDDARKRAKQ 4597
E ++ + + ++ + + L + +Q+ E Q+S+ E + ++A + A++
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARR 1653
Query: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH--KEFQKTLGGKQPVYDTTIR 4655
+A ++ + E AE L+ + +++ + +L + + +T G+Q
Sbjct: 1654 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1713
Query: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
R +E + Q+L+ L +VR + + + + EE+ S + L+A
Sbjct: 1714 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAE 1770
Query: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775
++ + A + + Q++L + Q R E
Sbjct: 1771 AGRFRELAEEAAR-----------LRALAEEAKRQRQLAEEDAARQ------RAEAERVL 1813
Query: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF--RDTVHMLLEWLSEAEQT 4833
+ G+ L T + K ++ RL + L + E F R + ++ E+
Sbjct: 1814 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1872
Query: 4834 L-RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKH 4892
L + R A + E + L++ ++VEE+ + + ++ A + +
Sbjct: 1873 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1932
Query: 4893 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIP 4952
+R++ + L A+Q Q E A + + L A + A R ++
Sbjct: 1933 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA------RQRKAAL 1986
Query: 4953 QNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI---EPTHAPFIEKSRSGGRKS 5009
+ ++R+KA + E + E ++ ++ + +K + E HA +++ +++
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2046
Query: 5010 LSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064
L Q + ++EA + Q A + +R++ +A +RL++ E
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAE 2100
Score = 39.7 bits (91), Expect = 0.082
Identities = 26/54 (48%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 5350 SASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRR 5403
S S GS AGSR GSR SR GS FD T S S T SS+ G RR
Sbjct: 4457 SVSGSGSTAGSRTGSRTGSRAGSRRGSFD--ATGSGFSMTFSSSSYSSSGYGRR 4508
Score = 34.3 bits (77), Expect = 3.5
Identities = 49/247 (19%), Positives = 98/247 (39%), Gaps = 25/247 (10%)
Query: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635
+V +S++R L+D+ R Q L+ W+E+ + +D E D ++ QL
Sbjct: 483 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 535
Query: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEK-TLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
H+ G Q + + + RA ++ L P + LG + ++ + S R
Sbjct: 536 HR------GLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 589
Query: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLM---DAHKVFQK 4751
LE F+ A + WL + E E++ D N+ +++ +
Sbjct: 590 LRSLESL----HSFVAAATKELMWLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMR 641
Query: 4752 ELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALK 4811
EL + ++ L+ +G L+ V+ L T+W + +L ++ L++
Sbjct: 642 ELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAA 701
Query: 4812 QAEVFRD 4818
+ F D
Sbjct: 702 YFQFFSD 708
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 1379 bits (3568), Expect = 0.0
Identities = 926/2808 (32%), Positives = 1488/2808 (52%), Gaps = 250/2808 (8%)
Query: 59 DSVLDPAERAVVR----VADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLIS 114
D +PA R + DERDRVQKKTFTKWVNKHL+K ++HI+DLYEDLRDGHNLIS
Sbjct: 23 DGGCEPARRGYLYQQLCCVDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLIS 82
Query: 115 LLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIW 174
LLEVLSG LPREKGRMRFH+LQNVQIALD+L+ RQVKLVNIRNDDI DGNPKLTLGLIW
Sbjct: 83 LLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIW 142
Query: 175 TIILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH 234
TIILHFQISDI +SG+S DM+AKEKLLLW+Q++ GY G++C NF+S W DG++FNA+IH
Sbjct: 143 TIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIH 202
Query: 235 RYRPDLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSI 293
R++P L+DM +V Q+N ENL+QAF VAER LGVTRLLD EDVDVP PDEKS+ITYVSS+
Sbjct: 203 RHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSL 262
Query: 294 YDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALY 353
YDA P+VP+ +G+ A E+ RWQEY+ V L+ W++ HT ++ FP + E++ L+
Sbjct: 263 YDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILW 322
Query: 354 NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML 413
+Q++ FKE E+ AKE +K R + +Y+ LE ++ G++K+P GYHP DVE+EWGKL + +L
Sbjct: 323 SQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAIL 382
Query: 414 EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV 473
EREK LR ERLE L +I K+Q A CEE+L A LQ+D L +G+ Q +V
Sbjct: 383 EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEV 442
Query: 474 IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT 533
+ + + +IR L D+Q L+D + Q E++ RV RL + LV +R E + G
Sbjct: 443 ERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG--- 499
Query: 534 SLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELL 593
A P T+ + S R+P EL ++ LR++ +LL
Sbjct: 500 ---------------VAAPATQVAQVTLQSVQRRP----EL-------EDSTLRYLQDLL 533
Query: 594 SWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTS 653
+WVEE Q +++ AEWG DLPSVE QL + + +H S+EE + ++ AR EG++S +
Sbjct: 534 AWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGA 593
Query: 654 YAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNS 713
Y + LG+L+ QY KL +S R+R L+SLH FV+ AT EL+WLNEKEEEE+ +DWSD N+
Sbjct: 594 YRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNT 653
Query: 714 NISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQ 773
N++AK+ +S L ELE K+ + LQ+ + L E+HPA+ TVE++ AA+Q+Q WM Q
Sbjct: 654 NMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQ 713
Query: 774 LCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMD 833
LC C+E H+KEN AYFQFFSD RE E L+ LQ++++RKYSCD + +++RLEDLLQD+ D
Sbjct: 714 LCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQD 773
Query: 834 EKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECV 893
EKEQL + K ++ L R+K +VQLKPR P H ++ + + AVCDY+Q+E+T+ K DEC
Sbjct: 774 EKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQ 833
Query: 894 LEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVN 953
L +Q + WKV+S +G+EA VPSVCFL+PPPN++A E +R+E +Q ++ LWHQLHV+
Sbjct: 834 LVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 893
Query: 954 TKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVA 1013
KSL++W LR+D+ L+++W+L R+ P E Q + +L+ HY+ FL+DS+D+ F
Sbjct: 894 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 953
Query: 1014 DRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQS 1073
DRL E E +C +Q L++S+E +EE+ + ISELK+IRL+LE E R V R++
Sbjct: 954 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR- 1012
Query: 1074 LASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRS 1133
D++ ++ A RIAEQ+ Q +++ L + +S + + L S + PTLRS
Sbjct: 1013 ---LPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS 1069
Query: 1134 ELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSAL 1193
EL L + K++ V LS +YL KLKT+ +++R Q AE +++ +E +L + + V A L L
Sbjct: 1070 ELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1129
Query: 1194 EAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQ 1253
EA ++L+ + + + F L +E+ A+ V E++ + ER++++ER++E+ +QL
Sbjct: 1130 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1189
Query: 1254 ERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLS 1313
ERW V+AQ ++RQ ELE + L YR L W+++ +QE ++ DS+ +
Sbjct: 1190 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1249
Query: 1314 EQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRR 1373
EQL Q+ AL EIER+ K+++CQ+F++QY +KDYELQL+TYKA +E SP K+ +
Sbjct: 1250 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPAKKPK 1308
Query: 1374 MLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKE 1433
+ S S+++ QE++DLRT Y+ L TLT+Q++K+IS+ LRR+EEEE++ E+++ E E++ E
Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1368
Query: 1434 LLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLA 1493
+ + L + Q ++ K + E L+Q+ + EE+ ++E +A
Sbjct: 1369 V---EAALEKQRQLAEAHAQAKAQAEREAKELQQR-MQEEVVRREEAAVDA--------- 1415
Query: 1494 KHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQ-SQLAHQTEQKTLQKQQNTC 1552
+++K+ I E+L L ++ A Q + + S+L + E + ++ Q
Sbjct: 1416 -------QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1468
Query: 1553 HQQL----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFAT 1608
+Q +L + +AE A A Q R Q++ L+ + +QD+ Q + +
Sbjct: 1469 ERQRGGAEGELQALRARAEEAEA--QKRQAQEEAERLR------RQVQDESQRKRQAEVE 1520
Query: 1609 VVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQE 1668
+ ++ E + K R L AL E QA+E E R+ Q E+E A + E
Sbjct: 1521 LASRVKAEAEAAREK--QRALQALEELRLQAEE------AERRLRQAEVERARQVQVALE 1572
Query: 1669 TEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGY 1728
T + A EL + S QL +L E ++ A L + A
Sbjct: 1573 TAQRSAEAELQSKR----------ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQ 1621
Query: 1729 MGVNQAPEKLDKQCEMMKARHQELLS---QQQNFILATQSAQAFLDQHGHNL-------- 1777
+A E+ +++ E + + E L Q + AQA ++
Sbjct: 1622 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1681
Query: 1778 TPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKE 1837
EEQ + Q++L E + + LA+ A+ Q + EL + + ++ E + E+E
Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQ--QRLAAEQELIRLRAETEQGEQQRQLLEEE 1739
Query: 1838 LENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSE 1897
L + + E + KRQ ++ + ++ + S + + S E
Sbjct: 1740 LARLQR-----EAAAATQKRQ-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---- 1789
Query: 1898 IGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEK 1957
K +L+ R+ L + RL + L + + Q A Q EA E+
Sbjct: 1790 -----KQRLEAEAGRFRELAEEAARLRA-----LAEEAKRQRQLAEEDAARQRAEA--ER 1837
Query: 1958 LLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARD----IMEIEGEPAPDHR 2013
+L++ +A+ + E + + L E + E+L+++A D +E + A
Sbjct: 1838 VLAEKLAA----IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1893
Query: 2014 HVQETTDSILSHFQSLSYSLAER-SSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQ 2072
++E L+ + S S ER L++ + Q + V+E + +L S E+ GK
Sbjct: 1894 DIEER----LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF---EKAAAGKA 1946
Query: 2073 VSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVS 2132
L G I+ ++ +++++ LEA R+ AA + + E
Sbjct: 1947 ELELELGRIRSNAEDTLR-----SKEQAELEAARQ----------RQLAAEEERRRREAE 1991
Query: 2133 QRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQ 2192
+R ++ ++E K L + E + + ++ E + A Q Q+
Sbjct: 1992 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2051
Query: 2193 QIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKERE 2252
Q +E QQ+ + + L E S L Q + + R+ E ++ + E
Sbjct: 2052 QAEEKAHAFAVQQKEQELQQTLQQEQSV------LDQLRGEAEAARRAAEEAEEARVQAE 2105
Query: 2253 KDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASK 2312
++A+ + Q++E +L ++ + E + + + + E L+ + A++
Sbjct: 2106 REAAQSRRQVEEAERLKQSAE-------------EQAQARAQAQAAAEKLRKEAEQEAAR 2152
Query: 2313 GTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDM 2372
E+ + + ME ++ T + +++ ++
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAE--------------------QTLRQKAQVEQEL 2192
Query: 2373 SDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTK 2432
+ + L+ E+ + E LQ + E ++ + V + L S ++ + + + +
Sbjct: 2193 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2252
Query: 2433 TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWE 2492
E L++ + K+++V E A L V +QEA +++ EE ++
Sbjct: 2253 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLRQLAEEDLAQQR 2309
Query: 2493 RATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ-KQ 2551
E + + Q + A+ L AE++L +KEL L D + Q +
Sbjct: 2310 ALAEKMLKEKMQAVQEATRL----KAEAELLQ--QQKELAQEQARRLQEDKEQMAQQLAE 2363
Query: 2552 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNS 2611
+ Q + EA RQ+ +++ A+ + ++S + ++ +++ Q ++ E+ +KL+
Sbjct: 2364 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH- 2422
Query: 2612 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 2671
R+ Q EKV V Q L +Q S ++ E +E+ +
Sbjct: 2423 RTELATQ----------------EKVTLV-QTLEIQRQQSDHD--AERLREAIAELEREK 2463
Query: 2672 EQLDHEVKEAQTLCDELSVLIGEQYL-------------KDELKKRLETVALPLQGLEDL 2718
E+L E K Q +E+ + EQ L KD L +R + LE L
Sbjct: 2464 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2523
Query: 2719 AADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQ 2778
D + + Q Q+ QQ ++ R L + + + E + ++ EE Q
Sbjct: 2524 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR-----QHEAEEGVRRKQEELQ 2578
Query: 2779 KSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS 2826
+ Q E++ E + L E+ + L+ Q H EE++
Sbjct: 2579 QLEQQRRQQEELLAEENQRL------REQLQLLEEQHRAALAHSEEVT 2620
Score = 131 bits (329), Expect = 2e-29
Identities = 322/1752 (18%), Positives = 693/1752 (39%), Gaps = 241/1752 (13%)
Query: 2635 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE 2694
E R QR++ Q + E + + + S + L A TL EL + +G+
Sbjct: 1018 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1077
Query: 2695 ----QYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750
+ L ++L+T++L ++G + A + + + L Q EL
Sbjct: 1078 LEQVRSLSAIYLEKLKTISLVIRGTQG-AEEVLRAHEEQLKEAQAVPATLPELEATKASL 1136
Query: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810
+ +A+ + L+ +L+ +E + L Q G +V E
Sbjct: 1137 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV----------------EVER 1180
Query: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV- 2869
+ ++ +L W+ + +T RQ L+ ++ + Y+ + L W++D + + +++
Sbjct: 1181 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1240
Query: 2870 -TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQN 2928
D + L + +A+L E+E+ +E A IN+ + E + KA + +
Sbjct: 1241 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-EP 1299
Query: 2929 MDAVTEELQAKTGSLEEMTQRLREFQESFKNIE-------KKVEGAKHQLEIFDALGSQA 2981
+ + ++ + ++GS E + Q + + + + K + ++E + L Q
Sbjct: 1300 VASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ- 1357
Query: 2982 CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV 3041
+ E+ EV ALE Q Q + A++E E+
Sbjct: 1358 ---QRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-----------------AEREAKEL 1397
Query: 3042 KQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD-ELDGMGAIGRDTDSLQSQIEDV 3100
+QR+ V E Q ++E QL + E+ + + +IE+
Sbjct: 1398 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1456
Query: 3101 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQ 3160
+I V++L +EA+E + G G + EL+AL + + + + QE+
Sbjct: 1457 -----EIRVVRLQLEATE-------RQRG-----GAEGELQALRARAEEAEAQKRQAQEE 1499
Query: 3161 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPL 3220
E +V+D ++ + + +AEA E + Q L + ++ Q +
Sbjct: 1500 AERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRL----QAEEA 1552
Query: 3221 QMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME-EINARWNTLNKKVAQRIAQLQEALLHC 3279
+ +L+Q +Q A ++ + E E+ ++ + +K AQ LQE +
Sbjct: 1553 ERRLRQAEVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1607
Query: 3280 GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT--VDML 3337
+ ++ E A+ E + AE ++ + Q++ + L+ L + +
Sbjct: 1608 AQLREEAERRAQQQAEAE-----RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1662
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397
QAE + + AE R + G+ E R EL + +Q+QL + A+Q +
Sbjct: 1663 QAEAEKQKEEAEREARRR--GKAEEQAVRQRELAEQELEKQRQLAE--GTAQQRLAAEQE 1718
Query: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKI---GQSLS 3454
+ + TE+ + + + A++Q++ +++E V +++ ++ +
Sbjct: 1719 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1778
Query: 3455 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED----------- 3503
S + +++++ R+ E+ + R AL ++A +L ED
Sbjct: 1779 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1838
Query: 3504 ----------------EVEVLNWLAEVEDKLSSVFVKD--FKQDVLHRQHADHLA-LNEE 3544
E E+ E E++ +D F++ L Q A H A + E
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1898
Query: 3545 IVNRKKNVDQAIKNGQALLKQT------TGEEVLLIQEKLDGIKTRYADITV-------T 3591
+ +K D ++ + L++ T EE+L ++ + A++ +
Sbjct: 1899 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1958
Query: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS-GGQSPTGEQIPQFQQRQKEL 3650
+ LR+ EQA A + + E RE EE + S + Q + + L
Sbjct: 1959 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2018
Query: 3651 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA 3710
K +V E R + + + S L+L A+E K + + + V + +
Sbjct: 2019 KAKVEEARRLRERAEQESARQLQL----AQEAAQKRLQAEEKAHAFA-------VQQKEQ 2067
Query: 3711 AIQRSQQYEQAADAELAWVAETKRKLMALGP---IRLEQDQTTAQLQVQKAFSIDIIRHK 3767
+Q++ Q EQ+ +L AE R+ ++ E++ ++ QV++A R K
Sbjct: 2068 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-----ERLK 2122
Query: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKT------ESLIQQYEA--ISLLNSERYAR--- 3816
S +E R++ + +K QE ++ ++Q +A + +++A
Sbjct: 2123 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182
Query: 3817 LERAQV------LVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 3870
++AQV L Q ET + + EE + L A+ A Q+ ++ +R E
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2242
Query: 3871 SIAEHKPHIDK-----LLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALAL 3925
+++ K I+ +L+ + EE E +++ ++A + +E R R LA
Sbjct: 2243 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA- 2301
Query: 3926 DEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEK 3985
+E ++Q + E + + E ++ + R + AE + +++ + A + +
Sbjct: 2302 EEDLAQQRALAE-----KMLKEKMQAVQEATR----LKAEAELLQQ---QKELAQEQARR 2349
Query: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045
LQ E ++ ++L +QG + L A E Q +L ++ A AE +++ ++
Sbjct: 2350 LQ---EDKEQMAQQLAEETQGFQRTLEA-ERQRQL--------EMSAEAERLKLRVAEMS 2397
Query: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105
+ D ++ + +H E +++V +T++ + + E
Sbjct: 2398 RAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEIQRQQSDHDAER 2451
Query: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER-LEKLEDAMQAAVQYQDTL 4164
+R A+L E EK ++++ + E + +E+ L++ + Q+ + +D+L
Sbjct: 2452 LREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2506
Query: 4165 QAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK 4224
+++ KL + +D++ + ++ + E +QQ +ME+ + ++
Sbjct: 2507 LQRERFIEQEKAKLEQL---------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2557
Query: 4225 KA---TDETDRDIIR--EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4279
+A E + + R E L +L+ E +A +L Q Q E+ +
Sbjct: 2558 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR------EQLQLLEEQHRA 2611
Query: 4280 WLTHTEELLDAQ 4291
L H+EE+ +Q
Sbjct: 2612 ALAHSEEVTASQ 2623
Score = 129 bits (325), Expect = 6e-29
Identities = 545/2630 (20%), Positives = 996/2630 (37%), Gaps = 398/2630 (15%)
Query: 1209 DKNSVFSVLD-EEIAKAKVVAEQ---MSRLTPERNLDLERYQEKG-----SQLQERWHRV 1259
D N V+ + E + +A VAE+ ++RL ++D+ + EK S L + RV
Sbjct: 210 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 269
Query: 1260 I-AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKPGQAEDSRVLSEQLS 1317
Q +R +EL+ + +YR L++W+ TA +E P E+ +L Q
Sbjct: 270 PDVQDGVRANELQLRWQ---EYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 326
Query: 1318 QQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSS 1377
+ + E+ + ++ + Q V+ +L++ PG
Sbjct: 327 KFKEM--ELPAKEADKNRSKGIYQSLEGAVQAGQLKV------------PPGYHP----- 367
Query: 1378 SDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGW 1437
+D+ + L + K + RLE +++V + + E +E L
Sbjct: 368 --------LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME-AGLCEEQLNQ 418
Query: 1438 VSTLARN-----TQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFL 1492
L ++ GK + D++KA ++L ++ T K+
Sbjct: 419 ADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD------------- 465
Query: 1493 AKH--GHKLSEKEKKQISEQLNALNKAYH-DLCDGSANQLQQLQSQLAHQTEQKTLQKQQ 1549
+H G ++ + + + E+L A+ Y+ L G A Q+ +Q+ Q+ Q+ + +
Sbjct: 466 GRHPQGEQMYRRVYR-LHERLVAIRTEYNLRLKAGVAAPATQV-AQVTLQSVQRRPELED 523
Query: 1550 NTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATV 1609
+T + L+DL +WV + + + G + DL +++ + L I+
Sbjct: 524 STL-RYLQDLLAWVEENQHRVDGAEWGV---DLPSVEAQLGSHRGLHQSIEEFRAKIERA 579
Query: 1610 VKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
D + +LSP A R+ L + QY L ++ + LE +
Sbjct: 580 RSD--------EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV----- 626
Query: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729
+ A KEL +K + VG TN+ ++ A + + L
Sbjct: 627 --AAATKELMWLNEKEEE------EVGFDWSDRNTNMTAKKESYSALMRELELKEKK-IK 677
Query: 1730 GVNQAPEKL---DKQCEMMKARHQELLSQQQNFIL-------ATQSAQAFLDQHGHNLTP 1779
+ A ++L D Q L Q +++L A A Q ++
Sbjct: 678 ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 737
Query: 1780 EEQQMLQQKLGE-LKEQYSTSLAQSEAELKQV-QTLQDELQKFLQDHKEFESWLERSEK- 1836
E Q+ QKL E L+ +YS + + L+ + Q QDE ++ L ++K S L + K
Sbjct: 738 AEGQL--QKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ-LNEYKGHLSGLAKRAKA 794
Query: 1837 --ELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQ----KVLDMENSFK 1890
+L+ H LP LL +V HKGD + Q KVL S
Sbjct: 795 VVQLKPRHPAHPMRGRLP-LLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-- 851
Query: 1891 EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950
E PS + LV ++A E T RL + L+ +HQ SL AW Q+
Sbjct: 852 EAAVPS-VCFLVPPPNQEAQEAVT-------RLEAQHQALVTLWHQLHVDMKSLLAW-QS 902
Query: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010
+V+ + S ++A+ T K ++ A H + + Q RD + G
Sbjct: 903 LRRDVQLIRSWSLAT--------FRTLKPEEQRQALHSLELH-YQAFLRDSQDAGGFGPE 953
Query: 2011 DHRHVQETTDSILSHFQSLSYSL---AERSSLLQKAIAQSQSVQESLESL-LQSIGEVEQ 2066
D + S H+Q L SL A+ S Q+ I++ + ++ LE+ +++ +
Sbjct: 954 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1013
Query: 2067 NLEGKQVSSLSSGVI--QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2124
L+ + + + Q+A A L + +AR L A E V E S A L
Sbjct: 1014 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR----LSAEAEKVLALPEP--SPAAPTL 1067
Query: 2125 QGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2181
+ +L + EQ L EK ++ ++ + E + ++ ++ + A+
Sbjct: 1068 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT-- 1125
Query: 2182 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---------DLCQHQD 2232
P+ + T +++L + E QQ D L + G L ++ + ++
Sbjct: 1126 LPELEATK--ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1183
Query: 2233 RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSA 2292
RV L + + + R+++ QL +R+ WL++ + A
Sbjct: 1184 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1243
Query: 2293 --KELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME-----ITAPDSQGKTGSI 2345
+ + +Q+ ++LL++ G VEE N I + +T S
Sbjct: 1244 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1303
Query: 2346 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2405
GS + DL +++ + +Y K R E + + + +
Sbjct: 1304 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1363
Query: 2406 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2465
E + ++ K+ L A + K + + + E+ + Q+ K ++
Sbjct: 1364 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 2466 GLLVTYPNSQEAENWKKIQE----------------------------------ELNSRW 2491
L S EAE K ++ EL +
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1483
Query: 2492 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 2551
RA E A++RQ +E A L ESQ R E EL V A +
Sbjct: 1484 ARAEEAE-AQKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQA 1541
Query: 2552 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ--VQKELQSINQKWVELTDKL 2609
+ L+ EA R+ + E A+ + V+L T+Q + ELQS + E T +L
Sbjct: 1542 LEELRLQAEEAERRLRQAEVERARQV-----QVALETAQRSAEAELQSKRASFAEKTAQL 1596
Query: 2610 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRS 2669
RS Q + V L++ +E+ RA Q + ++ + E + QL+ +R
Sbjct: 1597 E-RSLQEEHVAVAQ------LREEAER-RAQQQAEAERAREEAERELERWQLKANEALRL 1648
Query: 2670 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK-RLETVALPLQGLEDLAADRINRLQA 2728
L+ EV + ++L + E+ ++ ++ + E A+ + L + ++ +L
Sbjct: 1649 RLQA--EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1706
Query: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQL----QENEEFQKSLNQH 2784
A Q+ + +R + +Q +Q + + +L RLQ + Q+ +E + L +
Sbjct: 1707 GTAQ-QRLAAEQELIRLRAETEQGEQQRQL-LEEELARLQREAAAATQKRQELEAELAKV 1764
Query: 2785 SGSYEVIVA-----EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK-----KTADRQS 2834
EV++A E ES S + K+ L+ + + EE ++ + A RQ
Sbjct: 1765 RAEMEVLLASKARAEEESRSTSE---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1821
Query: 2835 RLKD---CMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVE 2891
+L + Q+A+ + E L E + K +E + L + E+ LR A +
Sbjct: 1822 QLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQ 1880
Query: 2892 KRRSLLEILNSAADI---LINSSEADEDGIRDEKAGINQNMDA---VTEELQAKTGSLEE 2945
+RR + ADI L +A + + +K + + V EE+ A S E+
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1940
Query: 2946 MTQRLREFQESFKNIEKKVEG---AKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
E + I E +K Q E+ A Q + + + A++ V ++L
Sbjct: 1941 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2000
Query: 3003 QVDYLRNFTQGLVEDA---PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG- 3058
+ + R L E +A +L +AE L++ Q + E K
Sbjct: 2001 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2060
Query: 3059 -IGQFHCRVREMFSQLADLDDELDGMGAIGR-------------DTDSLQS--QIEDVRL 3102
+ Q +++ Q + D+L G R + ++ QS Q+E+
Sbjct: 2061 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2120
Query: 3103 FLNKIH------------VLKLDIEASEAECRHMLEEEGTL-DLLGLKRELEALNKQCGK 3149
KL EA + R E+ L E+E +K+ +
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-HKKFAE 2179
Query: 3150 LTERGKARQEQLELTLGRVE----DFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
T R KA+ EQ ELT R++ D + L AE EA + E E+ + +
Sbjct: 2180 QTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2238
Query: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265
+ Q E++ L+ +++ N + LI KD + L+ + E++ K+V
Sbjct: 2239 V------QMEELSKLKARIEAEN---RALILR-DKDNTQRFLQEEAEKM--------KQV 2280
Query: 3266 AQRIAQLQEALLHCGKFQD-ALEPLLSWLADTEELIANQKPPSAEYKVVKAQ---IQEQK 3321
A+ A+L A + + A E L A E+++ + E +KA+ +Q+QK
Sbjct: 2281 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2340
Query: 3322 LL-----QRLLDDRKATVDML--QAEGGRIAQSAELADREKITGQLESLESRWTELLSKA 3374
L +RL +D++ L + +G + AE + +++ + E L+ R E+ S+A
Sbjct: 2341 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRA 2399
Query: 3375 AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKA-- 3431
AR + ED A++F + AE I + L TE LA E V QT +IQ+Q H A
Sbjct: 2400 QARAE--ED----AQRFRKQAEEIGEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAER 2451
Query: 3432 LEE---DIENHATDVHQAVKIGQ------------SLSSLTSPAEQGVLSEKIDSLQARY 3476
L E ++E + Q K+ Q L T +Q LSEK DSL R
Sbjct: 2452 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-DSLLQRE 2510
Query: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEV------------------------------- 3505
I+ + L ++ A+ E++
Sbjct: 2511 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2570
Query: 3506 ----EVLNWLAEVEDKLSSVFVKDFKQ-----DVLHRQHADHLALNEEIVNRKKNVDQAI 3556
E L L + + + ++ ++ +L QH LA +EE+ + + +
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2630
Query: 3557 KNGQALLKQTTGEEVLLIQEKLDGIK-----TRYADITVTSSKALRTLEQ 3601
NG+ L E + DG++ R + + S++ L+ L Q
Sbjct: 2631 PNGRDALDGPAAEAE--PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2678
Score = 100 bits (249), Expect = 4e-20
Identities = 318/1624 (19%), Positives = 619/1624 (38%), Gaps = 261/1624 (16%)
Query: 3221 QMKLQ-QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC 3279
Q K Q +V GLG+G+ + + + V L E + TL ++ + +L++
Sbjct: 1030 QQKAQAEVEGLGKGVARLSAEAEKVLALP----EPSPAAPTLRSELELTLGKLEQVRSLS 1085
Query: 3280 GKFQDALEPLLSWLADT---EELIANQKPPSAEYKVVKAQIQEQ-------KLLQRLLDD 3329
+ + L+ + + T EE++ + E + V A + E K L+ +
Sbjct: 1086 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1145
Query: 3330 RKATVDMLQAE-------GGRIAQSAELAD------REKITGQLESLESRWTELLSKAAA 3376
++ T D L+ E G R+ Q D RE++ LE RW +L++
Sbjct: 1146 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE----RWQAVLAQTDV 1201
Query: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKALEED 3435
RQ++LE + + + E+A+P+ +L ++ + + + +++Q+ + +AL E+
Sbjct: 1202 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1261
Query: 3436 IENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495
IE H V + + A+Q + + K LQ + Q A + S
Sbjct: 1262 IERHGEKVEECQRF----------AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1311
Query: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD-Q 3554
+ ++ V++ +E+ L+S ++K + + + + LA + R++ + +
Sbjct: 1312 GSESVIQEYVDLRTHYSEL-TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1370
Query: 3555 AIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 3614
A Q L + + + + ++ R + V +A +Q + +S E
Sbjct: 1371 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK------RSIQE 1424
Query: 3615 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLD-TVNEVSRALLE 3673
EL + E E+ Q+ E + + +++E+ RL L+ T + A E
Sbjct: 1425 ELQQLRQSSEAEIQAKARQAEAAE------RSRLRIEEEIRVVRLQLEATERQRGGAEGE 1478
Query: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----QAADAELAWV 3729
L RAR +A Q + + + ++ QR +Q E AE
Sbjct: 1479 LQALRAR------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1532
Query: 3730 AETKRKLMALGPIRL---EQDQTTAQLQVQKAFSIDI---IRHKDSMDELFSHRSEIFGT 3783
E +R L AL +RL E ++ Q +V++A + + + + EL S R+
Sbjct: 1533 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF--- 1589
Query: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW-IEETR 3842
+KT E+ SL +++ A++ L E R ++ E EL W ++
Sbjct: 1590 ---AEKTAQLER--SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1644
Query: 3843 ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902
AL +L + + ++ Q E +Q E+ E + + +E + E+ E+
Sbjct: 1645 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------GKAEEQAVRQRELAEQ 1696
Query: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962
+ +K Q+ E Q+ LA ++ + + TE ++ +LE E L+ R+
Sbjct: 1697 ELEKQR----QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE--EELA---RLQREA 1747
Query: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4022
A K +E ++ E+E L S K R EE RS + + +
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLAS----KARAEE-ESRSTSEKSKQRLEAEAGRFRE 1802
Query: 4023 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4082
+ ++A AEE + + +LAE+ A + + + L + G + + +
Sbjct: 1803 LAEEAARLRALAEEAKRQ----RQLAEE-----DAARQRAEAERVLAEKLAAIG-EATRL 1852
Query: 4083 KQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT 4142
K + E A KE E E +R L D F E+ + D + L K
Sbjct: 1853 KTEAEIALKEKE------AENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKA 1905
Query: 4143 WKERLEK----LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP-PVGTDLNTVKDQLNE 4197
LE+ +ED ++ Q ++ + A+ + + +G + +D L
Sbjct: 1906 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1965
Query: 4198 MKEFKVEVYQQQ---IEMEKLNHQGELMLKK--ATDETDRDIIREPLTELKHLWENLGE- 4251
++ ++E +Q+ E E+ + E ++K A +E + L E++ L + E
Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025
Query: 4252 -KIAHRQHKLEGALLALGQ-----------------FQHALEELMSWLTHTEELLDAQRP 4293
++ R + L L Q Q +EL L + +LD R
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2085
Query: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN----ELLESSAGDDASSLRSRLE 4349
E E A+ + + QA E E L+ SA + A +
Sbjct: 2086 --------EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2137
Query: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE--------------DFLLELTRMES 4395
A + + Q+ R Q Q+ L+Q Q +E+E ELT +
Sbjct: 2138 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2197
Query: 4396 QLSASKPTGGL------------PETAREQLDTHMELY---------SQLKAKEETYNQL 4434
QL + L E AR++ EL+ S+LKA+ E N+
Sbjct: 2198 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2257
Query: 4435 L---DKGRLMLLSRDDSGSGSKTEQSVALLE------------------QKWHVVSSKME 4473
L DK ++++ + + A L Q+ + ++
Sbjct: 2258 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2317
Query: 4474 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI-----EEHK 4528
E+ ++EA L E + L +Q +A + L Q+ EE +
Sbjct: 2318 EKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2366
Query: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588
F + A R + +E+ +LK + + Q+R E+ QR ++ +
Sbjct: 2367 GFQRTLEAERQRQLEMSAEAERLKLRVAE---------MSRAQARAEEDAQRFRKQAEEI 2417
Query: 4589 DDARKRAKQFHEAWKKLIDWLE--------DAESHLDSELEISNDPDKIKLQ---LSKHK 4637
+ R + + L+ LE DAE ++ E+ + +K++ + L
Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2477
Query: 4638 EFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDS-QKLDNFLGEVRDKWDTVCGKSVERQH 4696
E +T+ +Q + +T +AL++ L +DS + + F+ + + K + + V +
Sbjct: 2478 EEMQTVQQEQLLQET-----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2532
Query: 4697 KLEE 4700
+L E
Sbjct: 2533 QLRE 2536
Score = 67.0 bits (162), Expect = 5e-10
Identities = 235/1255 (18%), Positives = 480/1255 (38%), Gaps = 105/1255 (8%)
Query: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 3922
EE RQ S+ + H L+ PE+ M E +Y + Y Q+ + + Q A
Sbjct: 924 EEQRQALHSL---ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGA 980
Query: 3923 LALDEAVSQSTQITEFHDKIEPMLETLENLS-SRLRMPPLIPAEVDKIREC---ISDNKS 3978
E I+E D I LE E + RLR +P + + REC I++ +
Sbjct: 981 ---QEESRCQRCISELKD-IRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQK 1032
Query: 3979 ATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038
A E+E L L E+++ + + AA ++ +L+ + E +++
Sbjct: 1033 AQAEVEGLGKGVARLSAEAEKVLALPEPSP---AAPTLRSELELTLGKLEQVRS-LSAIY 1088
Query: 4039 IKFLDVLELAEKFWYDMAALLTT----IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094
++ L + L + +L +K+ Q + L + +K+ AE +
Sbjct: 1089 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1148
Query: 4095 ETDGLHEELEFIRILGADLIFACGE--TEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152
D L +EL + +G L GE E R+ + ++ W+ + R +LE
Sbjct: 1149 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208
Query: 4153 AMQAAVQYQDTLQAMFDWLDNT---VIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQ-- 4207
+ Y+++ + WL + ++ MP D V++QL + + E+ +
Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL--ADSQAVREQLRQEQALLEEIERHG 1266
Query: 4208 ------QQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN---LGEKIAHRQH 4258
Q+ + +N + L+ T + + + P + K + + E + R H
Sbjct: 1267 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1326
Query: 4259 KLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--------LAKHHV 4310
E L Q+ + E + + E L + QR + ++ EVE LA+ H
Sbjct: 1327 YSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHA 1384
Query: 4311 LKNDVLAHQATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4368
+ A + E + E++ E +A D RS E + Q +S + + + +Q
Sbjct: 1385 -QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1443
Query: 4369 LQSTLQQAQGFHSEIEDFLLELTRMESQLSAS----KPTGGLPETAREQLDTHMELYSQL 4424
++ + EI L+L E Q + + E A Q E +L
Sbjct: 1444 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1503
Query: 4425 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA-L 4483
+ + + +Q + + L SR + + + E+ AL Q + + EE + +L +A +
Sbjct: 1504 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEV 1561
Query: 4484 NLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA---NEVNAHRDQ 4540
A + Q +L E AE AS S EEH A E Q
Sbjct: 1562 ERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620
Query: 4541 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI---ERGRSLDDARKRAKQ 4597
E ++ + + ++ + + L + +Q+ E Q+S+ E + ++A + A++
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARR 1679
Query: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH--KEFQKTLGGKQPVYDTTIR 4655
+A ++ + E AE L+ + +++ + +L + + +T G+Q
Sbjct: 1680 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1739
Query: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
R +E + Q+L+ L +VR + + + + EE+ S + L+A
Sbjct: 1740 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAE 1796
Query: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775
++ + A + + Q++L + Q R E
Sbjct: 1797 AGRFRELAEEAAR-----------LRALAEEAKRQRQLAEEDAARQ------RAEAERVL 1839
Query: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF--RDTVHMLLEWLSEAEQT 4833
+ G+ L T + K ++ RL + L + E F R + ++ E+
Sbjct: 1840 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1898
Query: 4834 L-RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKH 4892
L + R A + E + L++ ++VEE+ + + ++ A + +
Sbjct: 1899 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1958
Query: 4893 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIP 4952
+R++ + L A+Q Q E A + + L A + A R ++
Sbjct: 1959 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA------RQRKAAL 2012
Query: 4953 QNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI---EPTHAPFIEKSRSGGRKS 5009
+ ++R+KA + E + E ++ ++ + +K + E HA +++ +++
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2072
Query: 5010 LSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064
L Q + ++EA + Q A + +R++ +A +RL++ E
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAE 2126
Score = 39.7 bits (91), Expect = 0.082
Identities = 26/54 (48%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 5350 SASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRR 5403
S S GS AGSR GSR SR GS FD T S S T SS+ G RR
Sbjct: 4483 SVSGSGSTAGSRTGSRTGSRAGSRRGSFD--ATGSGFSMTFSSSSYSSSGYGRR 4534
Score = 34.3 bits (77), Expect = 3.5
Identities = 49/247 (19%), Positives = 98/247 (39%), Gaps = 25/247 (10%)
Query: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635
+V +S++R L+D+ R Q L+ W+E+ + +D E D ++ QL
Sbjct: 509 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 561
Query: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEK-TLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
H+ G Q + + + RA ++ L P + LG + ++ + S R
Sbjct: 562 HR------GLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 615
Query: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLM---DAHKVFQK 4751
LE F+ A + WL + E E++ D N+ +++ +
Sbjct: 616 LRSLESL----HSFVAAATKELMWLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMR 667
Query: 4752 ELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALK 4811
EL + ++ L+ +G L+ V+ L T+W + +L ++ L++
Sbjct: 668 ELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAA 727
Query: 4812 QAEVFRD 4818
+ F D
Sbjct: 728 YFQFFSD 734
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 1378 bits (3566), Expect = 0.0
Identities = 922/2789 (33%), Positives = 1482/2789 (53%), Gaps = 246/2789 (8%)
Query: 74 DERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRF 133
DERDRVQKKTFTKWVNKHL+K ++HI+DLYEDLRDGHNLISLLEVLSG LPREKGRMRF
Sbjct: 38 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 97
Query: 134 HRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGD 193
H+LQNVQIALD+L+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI +SG+S D
Sbjct: 98 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 157
Query: 194 MSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRE 253
M+AKEKLLLW+Q++ GY G++C NF+S W DG++FNA+IHR++P L+DM +V Q+N E
Sbjct: 158 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 217
Query: 254 NLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEV 312
NL+QAF VAER LGVTRLLD EDVDVP PDEKS+ITYVSS+YDA P+VP+ +G+ A E+
Sbjct: 218 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 277
Query: 313 DSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKG 372
RWQEY+ V L+ W++ HT ++ FP + E++ L++Q++ FKE E+ AKE +K
Sbjct: 278 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 337
Query: 373 RIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQI 432
R + +Y+ LE ++ G++K+P GYHP DVE+EWGKL + +LEREK LR ERLE L +I
Sbjct: 338 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 397
Query: 433 ANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQ 492
K+Q A CEE+L A LQ+D L +G+ Q +V + + + +IR L D+Q
Sbjct: 398 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 457
Query: 493 ILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEP 552
L+D + Q E++ RV RL + LV +R E + G A P
Sbjct: 458 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG------------------VAAP 499
Query: 553 LTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDL 612
T+ + S R+P EL ++ LR++ +LL+WVEE Q +++ AEWG DL
Sbjct: 500 ATQVAQVTLQSVQRRP----EL-------EDSTLRYLQDLLAWVEENQHRVDGAEWGVDL 548
Query: 613 PSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETS 672
PSVE QL + + +H S+EE + ++ AR EG++S +Y + LG+L+ QY KL +S
Sbjct: 549 PSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSS 608
Query: 673 SFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEK 732
R+R L+SLH FV+ AT EL+WLNEKEEEE+ +DWSD N+N++AK+ +S L ELE K
Sbjct: 609 KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 668
Query: 733 QDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFF 792
+ + LQ+ + L E+HPA+ TVE++ AA+Q+Q WM QLC C+E H+KEN AYFQFF
Sbjct: 669 EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFF 728
Query: 793 SDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRS 852
SD RE E L+ LQ++++RKYSCD + +++RLEDLLQD+ DEKEQL + K ++ L R+
Sbjct: 729 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 788
Query: 853 KTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNE 912
K +VQLKPR P H ++ + + AVCDY+Q+E+T+ K DEC L +Q + WKV+S +G+E
Sbjct: 789 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 848
Query: 913 AMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQT 972
A VPSVCFL+PPPN++A E +R+E +Q ++ LWHQLHV+ KSL++W LR+D+ L+++
Sbjct: 849 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 908
Query: 973 WNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHL 1032
W+L R+ P E Q + +L+ HY+ FL+DS+D+ F DRL E E +C +Q L
Sbjct: 909 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQL 968
Query: 1033 MKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIA 1092
++S+E +EE+ + ISELK+IRL+LE E R V R++ D++ ++ A RIA
Sbjct: 969 LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR----LPLDKEPARECAQRIA 1024
Query: 1093 EQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVY 1152
EQ+ Q +++ L + +S + + L S + PTLRSEL L + K++ V LS +Y
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1084
Query: 1153 LNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNS 1212
L KLKT+ +++R Q AE +++ +E +L + + V A L LEA ++L+ + + +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1144
Query: 1213 VFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELES 1272
F L +E+ A+ V E++ + ER++++ER++E+ +QL ERW V+AQ ++RQ ELE
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 1273 IQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTK 1332
+ L YR L W+++ +QE ++ DS+ + EQL Q+ AL EIER+ K
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264
Query: 1333 LDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRY 1392
+++CQ+F++QY +KDYELQL+TYKA +E SP K+ ++ S S+++ QE++DLRT Y
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPAKKPKVQSGSESVIQEYVDLRTHY 1323
Query: 1393 TALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS 1452
+ L TLT+Q++K+IS+ LRR+EEEE++ E+++ E E++ E+ + L + Q +
Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV---EAALEKQRQLAEAHA 1380
Query: 1453 ETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLN 1512
+ K + E L+Q+ + EE+ ++E +A +++K+ I E+L
Sbjct: 1381 QAKAQAEREAKELQQR-MQEEVVRREEAAVDA----------------QQQKRSIQEELQ 1423
Query: 1513 ALNKAYHDLCDGSANQLQQLQ-SQLAHQTEQKTLQKQQNTCHQQL----EDLCSWVGQAE 1567
L ++ A Q + + S+L + E + ++ Q +Q +L + +AE
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1483
Query: 1568 RALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPR 1627
A A Q R Q++ L+ + +QD+ Q + + + ++ E + K R
Sbjct: 1484 EAEA--QKRQAQEEAERLR------RQVQDESQRKRQAEVELASRVKAEAEAAREK--QR 1533
Query: 1628 ELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDA 1687
L AL E QA+E E R+ Q E+E A + ET + A EL +
Sbjct: 1534 ALQALEELRLQAEE------AERRLRQAEVERARQVQVALETAQRSAEAELQSKR----- 1582
Query: 1688 LLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKA 1747
S QL +L E ++ A L + A +A E+ +++ E +
Sbjct: 1583 -----ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1636
Query: 1748 RHQELLS---QQQNFILATQSAQAFLDQHGHNL--------TPEEQQMLQQKLGELKEQY 1796
+ E L Q + AQA ++ EEQ + Q++L E + +
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 1797 STSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLK 1856
LA+ A+ Q + EL + + ++ E + E+EL + + E + K
Sbjct: 1697 QRQLAEGTAQ--QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-----EAAAATQK 1749
Query: 1857 RQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTAL 1916
RQ ++ + ++ + S + + S E K +L+ R+ L
Sbjct: 1750 RQ-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---------KQRLEAEAGRFREL 1799
Query: 1917 HSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLAT 1976
+ RL + L + + Q A Q EA E++L++ +A+ + E
Sbjct: 1800 AEEAARLRA-----LAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAA----IGEATRL 1848
Query: 1977 TKQLQEELAEHQVPVEKLQKVARD----IMEIEGEPAPDHRHVQETTDSILSHFQSLSYS 2032
+ + L E + E+L+++A D +E + A ++E L+ + S S
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKASDS 1904
Query: 2033 LAER-SSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKL 2091
ER L++ + Q + V+E + +L S E+ GK L G I+ ++
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASF---EKAAAGKAELELELGRIRSNAEDTLR- 1960
Query: 2092 KQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKK 2151
+++++ LEA R+ AA + + E +R ++ ++E K
Sbjct: 1961 ----SKEQAELEAARQ----------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006
Query: 2152 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL 2211
L + E + + ++ E + A Q Q+ Q +E QQ+ +
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066
Query: 2212 EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRT 2271
+ L E S L Q + + R+ E ++ + E++A+ + Q++E +L ++
Sbjct: 2067 QTLQQEQSV------LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120
Query: 2272 FQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIM 2331
+ E + + + + E L+ + A++ E+ + + M
Sbjct: 2121 AE-------------EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2167
Query: 2332 EITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQE 2391
E ++ T + +++ +++ + L+ E+ + E
Sbjct: 2168 EKHKKFAE--------------------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 2392 SLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELE 2451
LQ + E ++ + V + L S ++ + + + + E L+
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267
Query: 2452 QNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 2511
+ + K+++V E A L V +QEA +++ EE ++ E + + Q + A+
Sbjct: 2268 EEAEKMKQVAEEAARLSVA---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 2512 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ-KQQVQFMLKEFEARRQQHEQL 2570
L AE++L +KEL L D + Q ++ Q + EA RQ+ ++
Sbjct: 2325 L----KAEAELLQ--QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 2571 NEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELL 2630
+ A+ + ++S + ++ +++ Q ++ E+ +KL+ R+ Q
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELATQ------------ 2425
Query: 2631 QDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV 2690
EKV V Q L +Q S ++ E +E+ + E+L E K Q +E+
Sbjct: 2426 ----EKVTLV-QTLEIQRQQSDHD--AERLREAIAELEREKEKLQQEAKLLQLKSEEMQT 2478
Query: 2691 LIGEQYL-------------KDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQ 2737
+ EQ L KD L +R + LE L D + + Q Q+ Q
Sbjct: 2479 VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2538
Query: 2738 QMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGES 2797
Q ++ R L + + + E + ++ EE Q+ Q E++ E +
Sbjct: 2539 QQMEQERQRLVASMEEARRR-----QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Query: 2798 LLLSVPPGEEKRTLQNQLVELKNHWEELS 2826
L E+ + L+ Q H EE++
Sbjct: 2594 L------REQLQLLEEQHRAALAHSEEVT 2616
Score = 131 bits (329), Expect = 2e-29
Identities = 322/1752 (18%), Positives = 693/1752 (39%), Gaps = 241/1752 (13%)
Query: 2635 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE 2694
E R QR++ Q + E + + + S + L A TL EL + +G+
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073
Query: 2695 ----QYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750
+ L ++L+T++L ++G + A + + + L Q EL
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQG-AEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132
Query: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810
+ +A+ + L+ +L+ +E + L Q G +V E
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV----------------EVER 1176
Query: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV- 2869
+ ++ +L W+ + +T RQ L+ ++ + Y+ + L W++D + + +++
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236
Query: 2870 -TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQN 2928
D + L + +A+L E+E+ +E A IN+ + E + KA + +
Sbjct: 1237 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-EP 1295
Query: 2929 MDAVTEELQAKTGSLEEMTQRLREFQESFKNIE-------KKVEGAKHQLEIFDALGSQA 2981
+ + ++ + ++GS E + Q + + + + K + ++E + L Q
Sbjct: 1296 VASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ- 1353
Query: 2982 CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV 3041
+ E+ EV ALE Q Q + A++E E+
Sbjct: 1354 ---QRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-----------------AEREAKEL 1393
Query: 3042 KQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD-ELDGMGAIGRDTDSLQSQIEDV 3100
+QR+ V E Q ++E QL + E+ + + +IE+
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1452
Query: 3101 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQ 3160
+I V++L +EA+E + G G + EL+AL + + + + QE+
Sbjct: 1453 -----EIRVVRLQLEATE-------RQRG-----GAEGELQALRARAEEAEAQKRQAQEE 1495
Query: 3161 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPL 3220
E +V+D ++ + + +AEA E + Q L + ++ Q +
Sbjct: 1496 AERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRL----QAEEA 1548
Query: 3221 QMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME-EINARWNTLNKKVAQRIAQLQEALLHC 3279
+ +L+Q +Q A ++ + E E+ ++ + +K AQ LQE +
Sbjct: 1549 ERRLRQAEVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603
Query: 3280 GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT--VDML 3337
+ ++ E A+ E + AE ++ + Q++ + L+ L + +
Sbjct: 1604 AQLREEAERRAQQQAEAE-----RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397
QAE + + AE R + G+ E R EL + +Q+QL + A+Q +
Sbjct: 1659 QAEAEKQKEEAEREARRR--GKAEEQAVRQRELAEQELEKQRQLAE--GTAQQRLAAEQE 1714
Query: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKI---GQSLS 3454
+ + TE+ + + + A++Q++ +++E V +++ ++ +
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774
Query: 3455 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED----------- 3503
S + +++++ R+ E+ + R AL ++A +L ED
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 3504 ----------------EVEVLNWLAEVEDKLSSVFVKD--FKQDVLHRQHADHLA-LNEE 3544
E E+ E E++ +D F++ L Q A H A + E
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 3545 IVNRKKNVDQAIKNGQALLKQT------TGEEVLLIQEKLDGIKTRYADITV-------T 3591
+ +K D ++ + L++ T EE+L ++ + A++ +
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954
Query: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS-GGQSPTGEQIPQFQQRQKEL 3650
+ LR+ EQA A + + E RE EE + S + Q + + L
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014
Query: 3651 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA 3710
K +V E R + + + S L+L A+E K + + + V + +
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQL----AQEAAQKRLQAEEKAHAFA-------VQQKEQ 2063
Query: 3711 AIQRSQQYEQAADAELAWVAETKRKLMALGP---IRLEQDQTTAQLQVQKAFSIDIIRHK 3767
+Q++ Q EQ+ +L AE R+ ++ E++ ++ QV++A R K
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-----ERLK 2118
Query: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKT------ESLIQQYEA--ISLLNSERYAR--- 3816
S +E R++ + +K QE ++ ++Q +A + +++A
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 3817 LERAQV------LVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 3870
++AQV L Q ET + + EE + L A+ A Q+ ++ +R E
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238
Query: 3871 SIAEHKPHIDK-----LLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALAL 3925
+++ K I+ +L+ + EE E +++ ++A + +E R R LA
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA- 2297
Query: 3926 DEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEK 3985
+E ++Q + E + + E ++ + R + AE + +++ + A + +
Sbjct: 2298 EEDLAQQRALAE-----KMLKEKMQAVQEATR----LKAEAELLQQ---QKELAQEQARR 2345
Query: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045
LQ E ++ ++L +QG + L A E Q +L ++ A AE +++ ++
Sbjct: 2346 LQ---EDKEQMAQQLAEETQGFQRTLEA-ERQRQL--------EMSAEAERLKLRVAEMS 2393
Query: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105
+ D ++ + +H E +++V +T++ + + E
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEIQRQQSDHDAER 2447
Query: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER-LEKLEDAMQAAVQYQDTL 4164
+R A+L E EK ++++ + E + +E+ L++ + Q+ + +D+L
Sbjct: 2448 LREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502
Query: 4165 QAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK 4224
+++ KL + +D++ + ++ + E +QQ +ME+ + ++
Sbjct: 2503 LQRERFIEQEKAKLEQL---------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Query: 4225 KA---TDETDRDIIR--EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4279
+A E + + R E L +L+ E +A +L Q Q E+ +
Sbjct: 2554 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR------EQLQLLEEQHRA 2607
Query: 4280 WLTHTEELLDAQ 4291
L H+EE+ +Q
Sbjct: 2608 ALAHSEEVTASQ 2619
Score = 129 bits (325), Expect = 6e-29
Identities = 545/2630 (20%), Positives = 996/2630 (37%), Gaps = 398/2630 (15%)
Query: 1209 DKNSVFSVLD-EEIAKAKVVAEQ---MSRLTPERNLDLERYQEKG-----SQLQERWHRV 1259
D N V+ + E + +A VAE+ ++RL ++D+ + EK S L + RV
Sbjct: 206 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 265
Query: 1260 I-AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKPGQAEDSRVLSEQLS 1317
Q +R +EL+ + +YR L++W+ TA +E P E+ +L Q
Sbjct: 266 PDVQDGVRANELQLRWQ---EYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 322
Query: 1318 QQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSS 1377
+ + E+ + ++ + Q V+ +L++ PG
Sbjct: 323 KFKEM--ELPAKEADKNRSKGIYQSLEGAVQAGQLKV------------PPGYHP----- 363
Query: 1378 SDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGW 1437
+D+ + L + K + RLE +++V + + E +E L
Sbjct: 364 --------LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME-AGLCEEQLNQ 414
Query: 1438 VSTLARN-----TQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFL 1492
L ++ GK + D++KA ++L ++ T K+
Sbjct: 415 ADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD------------- 461
Query: 1493 AKH--GHKLSEKEKKQISEQLNALNKAYH-DLCDGSANQLQQLQSQLAHQTEQKTLQKQQ 1549
+H G ++ + + + E+L A+ Y+ L G A Q+ +Q+ Q+ Q+ + +
Sbjct: 462 GRHPQGEQMYRRVYR-LHERLVAIRTEYNLRLKAGVAAPATQV-AQVTLQSVQRRPELED 519
Query: 1550 NTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATV 1609
+T + L+DL +WV + + + G + DL +++ + L I+
Sbjct: 520 STL-RYLQDLLAWVEENQHRVDGAEWGV---DLPSVEAQLGSHRGLHQSIEEFRAKIERA 575
Query: 1610 VKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
D + +LSP A R+ L + QY L ++ + LE +
Sbjct: 576 RSD--------EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV----- 622
Query: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729
+ A KEL +K + VG TN+ ++ A + + L
Sbjct: 623 --AAATKELMWLNEKEEE------EVGFDWSDRNTNMTAKKESYSALMRELELKEKK-IK 673
Query: 1730 GVNQAPEKL---DKQCEMMKARHQELLSQQQNFIL-------ATQSAQAFLDQHGHNLTP 1779
+ A ++L D Q L Q +++L A A Q ++
Sbjct: 674 ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 733
Query: 1780 EEQQMLQQKLGE-LKEQYSTSLAQSEAELKQV-QTLQDELQKFLQDHKEFESWLERSEK- 1836
E Q+ QKL E L+ +YS + + L+ + Q QDE ++ L ++K S L + K
Sbjct: 734 AEGQL--QKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ-LNEYKGHLSGLAKRAKA 790
Query: 1837 --ELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQ----KVLDMENSFK 1890
+L+ H LP LL +V HKGD + Q KVL S
Sbjct: 791 VVQLKPRHPAHPMRGRLP-LLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-- 847
Query: 1891 EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950
E PS + LV ++A E T RL + L+ +HQ SL AW Q+
Sbjct: 848 EAAVPS-VCFLVPPPNQEAQEAVT-------RLEAQHQALVTLWHQLHVDMKSLLAW-QS 898
Query: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010
+V+ + S ++A+ T K ++ A H + + Q RD + G
Sbjct: 899 LRRDVQLIRSWSLAT--------FRTLKPEEQRQALHSLELH-YQAFLRDSQDAGGFGPE 949
Query: 2011 DHRHVQETTDSILSHFQSLSYSL---AERSSLLQKAIAQSQSVQESLESL-LQSIGEVEQ 2066
D + S H+Q L SL A+ S Q+ I++ + ++ LE+ +++ +
Sbjct: 950 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1009
Query: 2067 NLEGKQVSSLSSGVI--QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2124
L+ + + + Q+A A L + +AR L A E V E S A L
Sbjct: 1010 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR----LSAEAEKVLALPEP--SPAAPTL 1063
Query: 2125 QGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2181
+ +L + EQ L EK ++ ++ + E + ++ ++ + A+
Sbjct: 1064 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT-- 1121
Query: 2182 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---------DLCQHQD 2232
P+ + T +++L + E QQ D L + G L ++ + ++
Sbjct: 1122 LPELEATK--ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1179
Query: 2233 RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSA 2292
RV L + + + R+++ QL +R+ WL++ + A
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1239
Query: 2293 --KELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME-----ITAPDSQGKTGSI 2345
+ + +Q+ ++LL++ G VEE N I + +T S
Sbjct: 1240 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1299
Query: 2346 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2405
GS + DL +++ + +Y K R E + + + +
Sbjct: 1300 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359
Query: 2406 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2465
E + ++ K+ L A + K + + + E+ + Q+ K ++
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 2466 GLLVTYPNSQEAENWKKIQE----------------------------------ELNSRW 2491
L S EAE K ++ EL +
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 2492 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 2551
RA E A++RQ +E A L ESQ R E EL V A +
Sbjct: 1480 ARAEEAE-AQKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 2552 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ--VQKELQSINQKWVELTDKL 2609
+ L+ EA R+ + E A+ + V+L T+Q + ELQS + E T +L
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQV-----QVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 2610 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRS 2669
RS Q + V L++ +E+ RA Q + ++ + E + QL+ +R
Sbjct: 1593 E-RSLQEEHVAVAQ------LREEAER-RAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 2670 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK-RLETVALPLQGLEDLAADRINRLQA 2728
L+ EV + ++L + E+ ++ ++ + E A+ + L + ++ +L
Sbjct: 1645 RLQA--EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1702
Query: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQL----QENEEFQKSLNQH 2784
A Q+ + +R + +Q +Q + + +L RLQ + Q+ +E + L +
Sbjct: 1703 GTAQ-QRLAAEQELIRLRAETEQGEQQRQL-LEEELARLQREAAAATQKRQELEAELAKV 1760
Query: 2785 SGSYEVIVA-----EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK-----KTADRQS 2834
EV++A E ES S + K+ L+ + + EE ++ + A RQ
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSE---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Query: 2835 RLKD---CMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVE 2891
+L + Q+A+ + E L E + K +E + L + E+ LR A +
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 2892 KRRSLLEILNSAADI---LINSSEADEDGIRDEKAGINQNMDA---VTEELQAKTGSLEE 2945
+RR + ADI L +A + + +K + + V EE+ A S E+
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1936
Query: 2946 MTQRLREFQESFKNIEKKVEG---AKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
E + I E +K Q E+ A Q + + + A++ V ++L
Sbjct: 1937 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996
Query: 3003 QVDYLRNFTQGLVEDA---PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG- 3058
+ + R L E +A +L +AE L++ Q + E K
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056
Query: 3059 -IGQFHCRVREMFSQLADLDDELDGMGAIGR-------------DTDSLQS--QIEDVRL 3102
+ Q +++ Q + D+L G R + ++ QS Q+E+
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2116
Query: 3103 FLNKIH------------VLKLDIEASEAECRHMLEEEGTL-DLLGLKRELEALNKQCGK 3149
KL EA + R E+ L E+E +K+ +
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-HKKFAE 2175
Query: 3150 LTERGKARQEQLELTLGRVE----DFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
T R KA+ EQ ELT R++ D + L AE EA + E E+ + +
Sbjct: 2176 QTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265
+ Q E++ L+ +++ N + LI KD + L+ + E++ K+V
Sbjct: 2235 V------QMEELSKLKARIEAEN---RALILR-DKDNTQRFLQEEAEKM--------KQV 2276
Query: 3266 AQRIAQLQEALLHCGKFQD-ALEPLLSWLADTEELIANQKPPSAEYKVVKAQ---IQEQK 3321
A+ A+L A + + A E L A E+++ + E +KA+ +Q+QK
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Query: 3322 LL-----QRLLDDRKATVDML--QAEGGRIAQSAELADREKITGQLESLESRWTELLSKA 3374
L +RL +D++ L + +G + AE + +++ + E L+ R E+ S+A
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRA 2395
Query: 3375 AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKA-- 3431
AR + ED A++F + AE I + L TE LA E V QT +IQ+Q H A
Sbjct: 2396 QARAE--ED----AQRFRKQAEEIGEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAER 2447
Query: 3432 LEE---DIENHATDVHQAVKIGQ------------SLSSLTSPAEQGVLSEKIDSLQARY 3476
L E ++E + Q K+ Q L T +Q LSEK DSL R
Sbjct: 2448 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-DSLLQRE 2506
Query: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEV------------------------------- 3505
I+ + L ++ A+ E++
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 3506 ----EVLNWLAEVEDKLSSVFVKDFKQ-----DVLHRQHADHLALNEEIVNRKKNVDQAI 3556
E L L + + + ++ ++ +L QH LA +EE+ + + +
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2626
Query: 3557 KNGQALLKQTTGEEVLLIQEKLDGIK-----TRYADITVTSSKALRTLEQ 3601
NG+ L E + DG++ R + + S++ L+ L Q
Sbjct: 2627 PNGRDALDGPAAEAE--PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2674
Score = 100 bits (249), Expect = 4e-20
Identities = 318/1624 (19%), Positives = 619/1624 (38%), Gaps = 261/1624 (16%)
Query: 3221 QMKLQ-QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC 3279
Q K Q +V GLG+G+ + + + V L E + TL ++ + +L++
Sbjct: 1026 QQKAQAEVEGLGKGVARLSAEAEKVLALP----EPSPAAPTLRSELELTLGKLEQVRSLS 1081
Query: 3280 GKFQDALEPLLSWLADT---EELIANQKPPSAEYKVVKAQIQEQ-------KLLQRLLDD 3329
+ + L+ + + T EE++ + E + V A + E K L+ +
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141
Query: 3330 RKATVDMLQAE-------GGRIAQSAELAD------REKITGQLESLESRWTELLSKAAA 3376
++ T D L+ E G R+ Q D RE++ LE RW +L++
Sbjct: 1142 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE----RWQAVLAQTDV 1197
Query: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKALEED 3435
RQ++LE + + + E+A+P+ +L ++ + + + +++Q+ + +AL E+
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 3436 IENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495
IE H V + + A+Q + + K LQ + Q A + S
Sbjct: 1258 IERHGEKVEECQRF----------AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1307
Query: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD-Q 3554
+ ++ V++ +E+ L+S ++K + + + + LA + R++ + +
Sbjct: 1308 GSESVIQEYVDLRTHYSEL-TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366
Query: 3555 AIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 3614
A Q L + + + + ++ R + V +A +Q + +S E
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK------RSIQE 1420
Query: 3615 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLD-TVNEVSRALLE 3673
EL + E E+ Q+ E + + +++E+ RL L+ T + A E
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAE------RSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----QAADAELAWV 3729
L RAR +A Q + + + ++ QR +Q E AE
Sbjct: 1475 LQALRAR------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 3730 AETKRKLMALGPIRL---EQDQTTAQLQVQKAFSIDI---IRHKDSMDELFSHRSEIFGT 3783
E +R L AL +RL E ++ Q +V++A + + + + EL S R+
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF--- 1585
Query: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW-IEETR 3842
+KT E+ SL +++ A++ L E R ++ E EL W ++
Sbjct: 1586 ---AEKTAQLER--SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640
Query: 3843 ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902
AL +L + + ++ Q E +Q E+ E + + +E + E+ E+
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------GKAEEQAVRQRELAEQ 1692
Query: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962
+ +K Q+ E Q+ LA ++ + + TE ++ +LE E L+ R+
Sbjct: 1693 ELEKQR----QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE--EELA---RLQREA 1743
Query: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4022
A K +E ++ E+E L S K R EE RS + + +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLAS----KARAEE-ESRSTSEKSKQRLEAEAGRFRE 1798
Query: 4023 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4082
+ ++A AEE + + +LAE+ A + + + L + G + + +
Sbjct: 1799 LAEEAARLRALAEEAKRQ----RQLAEE-----DAARQRAEAERVLAEKLAAIG-EATRL 1848
Query: 4083 KQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT 4142
K + E A KE E E +R L D F E+ + D + L K
Sbjct: 1849 KTEAEIALKEKE------AENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKA 1901
Query: 4143 WKERLEK----LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP-PVGTDLNTVKDQLNE 4197
LE+ +ED ++ Q ++ + A+ + + +G + +D L
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 4198 MKEFKVEVYQQQ---IEMEKLNHQGELMLKK--ATDETDRDIIREPLTELKHLWENLGE- 4251
++ ++E +Q+ E E+ + E ++K A +E + L E++ L + E
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 4252 -KIAHRQHKLEGALLALGQ-----------------FQHALEELMSWLTHTEELLDAQRP 4293
++ R + L L Q Q +EL L + +LD R
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2081
Query: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN----ELLESSAGDDASSLRSRLE 4349
E E A+ + + QA E E L+ SA + A +
Sbjct: 2082 --------EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE--------------DFLLELTRMES 4395
A + + Q+ R Q Q+ L+Q Q +E+E ELT +
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2193
Query: 4396 QLSASKPTGGL------------PETAREQLDTHMELY---------SQLKAKEETYNQL 4434
QL + L E AR++ EL+ S+LKA+ E N+
Sbjct: 2194 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2253
Query: 4435 L---DKGRLMLLSRDDSGSGSKTEQSVALLE------------------QKWHVVSSKME 4473
L DK ++++ + + A L Q+ + ++
Sbjct: 2254 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2313
Query: 4474 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI-----EEHK 4528
E+ ++EA L E + L +Q +A + L Q+ EE +
Sbjct: 2314 EKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588
F + A R + +E+ +LK + + Q+R E+ QR ++ +
Sbjct: 2363 GFQRTLEAERQRQLEMSAEAERLKLRVAE---------MSRAQARAEEDAQRFRKQAEEI 2413
Query: 4589 DDARKRAKQFHEAWKKLIDWLE--------DAESHLDSELEISNDPDKIKLQ---LSKHK 4637
+ R + + L+ LE DAE ++ E+ + +K++ + L
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2473
Query: 4638 EFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDS-QKLDNFLGEVRDKWDTVCGKSVERQH 4696
E +T+ +Q + +T +AL++ L +DS + + F+ + + K + + V +
Sbjct: 2474 EEMQTVQQEQLLQET-----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2528
Query: 4697 KLEE 4700
+L E
Sbjct: 2529 QLRE 2532
Score = 67.0 bits (162), Expect = 5e-10
Identities = 235/1255 (18%), Positives = 480/1255 (38%), Gaps = 105/1255 (8%)
Query: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 3922
EE RQ S+ + H L+ PE+ M E +Y + Y Q+ + + Q A
Sbjct: 920 EEQRQALHSL---ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGA 976
Query: 3923 LALDEAVSQSTQITEFHDKIEPMLETLENLS-SRLRMPPLIPAEVDKIREC---ISDNKS 3978
E I+E D I LE E + RLR +P + + REC I++ +
Sbjct: 977 ---QEESRCQRCISELKD-IRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQK 1028
Query: 3979 ATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038
A E+E L L E+++ + + AA ++ +L+ + E +++
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSP---AAPTLRSELELTLGKLEQVRS-LSAIY 1084
Query: 4039 IKFLDVLELAEKFWYDMAALLTT----IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094
++ L + L + +L +K+ Q + L + +K+ AE +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1144
Query: 4095 ETDGLHEELEFIRILGADLIFACGE--TEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152
D L +EL + +G L GE E R+ + ++ W+ + R +LE
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 4153 AMQAAVQYQDTLQAMFDWLDNT---VIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQ-- 4207
+ Y+++ + WL + ++ MP D V++QL + + E+ +
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL--ADSQAVREQLRQEQALLEEIERHG 1262
Query: 4208 ------QQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN---LGEKIAHRQH 4258
Q+ + +N + L+ T + + + P + K + + E + R H
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322
Query: 4259 KLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--------LAKHHV 4310
E L Q+ + E + + E L + QR + ++ EVE LA+ H
Sbjct: 1323 YSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHA 1380
Query: 4311 LKNDVLAHQATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4368
+ A + E + E++ E +A D RS E + Q +S + + + +Q
Sbjct: 1381 -QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1439
Query: 4369 LQSTLQQAQGFHSEIEDFLLELTRMESQLSAS----KPTGGLPETAREQLDTHMELYSQL 4424
++ + EI L+L E Q + + E A Q E +L
Sbjct: 1440 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1499
Query: 4425 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA-L 4483
+ + + +Q + + L SR + + + E+ AL Q + + EE + +L +A +
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEV 1557
Query: 4484 NLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA---NEVNAHRDQ 4540
A + Q +L E AE AS S EEH A E Q
Sbjct: 1558 ERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616
Query: 4541 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI---ERGRSLDDARKRAKQ 4597
E ++ + + ++ + + L + +Q+ E Q+S+ E + ++A + A++
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARR 1675
Query: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH--KEFQKTLGGKQPVYDTTIR 4655
+A ++ + E AE L+ + +++ + +L + + +T G+Q
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735
Query: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
R +E + Q+L+ L +VR + + + + EE+ S + L+A
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAE 1792
Query: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775
++ + A + + Q++L + Q R E
Sbjct: 1793 AGRFRELAEEAAR-----------LRALAEEAKRQRQLAEEDAARQ------RAEAERVL 1835
Query: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF--RDTVHMLLEWLSEAEQT 4833
+ G+ L T + K ++ RL + L + E F R + ++ E+
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 4834 L-RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKH 4892
L + R A + E + L++ ++VEE+ + + ++ A + +
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954
Query: 4893 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIP 4952
+R++ + L A+Q Q E A + + L A + A R ++
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA------RQRKAAL 2008
Query: 4953 QNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI---EPTHAPFIEKSRSGGRKS 5009
+ ++R+KA + E + E ++ ++ + +K + E HA +++ +++
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 5010 LSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064
L Q + ++EA + Q A + +R++ +A +RL++ E
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAE 2122
Score = 39.7 bits (91), Expect = 0.082
Identities = 26/54 (48%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 5350 SASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRR 5403
S S GS AGSR GSR SR GS FD T S S T SS+ G RR
Sbjct: 4479 SVSGSGSTAGSRTGSRTGSRAGSRRGSFD--ATGSGFSMTFSSSSYSSSGYGRR 4530
Score = 34.3 bits (77), Expect = 3.5
Identities = 49/247 (19%), Positives = 98/247 (39%), Gaps = 25/247 (10%)
Query: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635
+V +S++R L+D+ R Q L+ W+E+ + +D E D ++ QL
Sbjct: 505 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 557
Query: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEK-TLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
H+ G Q + + + RA ++ L P + LG + ++ + S R
Sbjct: 558 HR------GLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 611
Query: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLM---DAHKVFQK 4751
LE F+ A + WL + E E++ D N+ +++ +
Sbjct: 612 LRSLESL----HSFVAAATKELMWLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMR 663
Query: 4752 ELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALK 4811
EL + ++ L+ +G L+ V+ L T+W + +L ++ L++
Sbjct: 664 ELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAA 723
Query: 4812 QAEVFRD 4818
+ F D
Sbjct: 724 YFQFFSD 730
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 1378 bits (3566), Expect = 0.0
Identities = 922/2789 (33%), Positives = 1482/2789 (53%), Gaps = 246/2789 (8%)
Query: 74 DERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRF 133
DERDRVQKKTFTKWVNKHL+K ++HI+DLYEDLRDGHNLISLLEVLSG LPREKGRMRF
Sbjct: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234
Query: 134 HRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGD 193
H+LQNVQIALD+L+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI +SG+S D
Sbjct: 235 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294
Query: 194 MSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRE 253
M+AKEKLLLW+Q++ GY G++C NF+S W DG++FNA+IHR++P L+DM +V Q+N E
Sbjct: 295 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354
Query: 254 NLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEV 312
NL+QAF VAER LGVTRLLD EDVDVP PDEKS+ITYVSS+YDA P+VP+ +G+ A E+
Sbjct: 355 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414
Query: 313 DSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKG 372
RWQEY+ V L+ W++ HT ++ FP + E++ L++Q++ FKE E+ AKE +K
Sbjct: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474
Query: 373 RIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQI 432
R + +Y+ LE ++ G++K+P GYHP DVE+EWGKL + +LEREK LR ERLE L +I
Sbjct: 475 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534
Query: 433 ANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQ 492
K+Q A CEE+L A LQ+D L +G+ Q +V + + + +IR L D+Q
Sbjct: 535 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594
Query: 493 ILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEP 552
L+D + Q E++ RV RL + LV +R E + G A P
Sbjct: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG------------------VAAP 636
Query: 553 LTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDL 612
T+ + S R+P EL ++ LR++ +LL+WVEE Q +++ AEWG DL
Sbjct: 637 ATQVAQVTLQSVQRRP----EL-------EDSTLRYLQDLLAWVEENQHRVDGAEWGVDL 685
Query: 613 PSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETS 672
PSVE QL + + +H S+EE + ++ AR EG++S +Y + LG+L+ QY KL +S
Sbjct: 686 PSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSS 745
Query: 673 SFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEK 732
R+R L+SLH FV+ AT EL+WLNEKEEEE+ +DWSD N+N++AK+ +S L ELE K
Sbjct: 746 KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 805
Query: 733 QDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFF 792
+ + LQ+ + L E+HPA+ TVE++ AA+Q+Q WM QLC C+E H+KEN AYFQFF
Sbjct: 806 EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFF 865
Query: 793 SDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRS 852
SD RE E L+ LQ++++RKYSCD + +++RLEDLLQD+ DEKEQL + K ++ L R+
Sbjct: 866 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 925
Query: 853 KTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNE 912
K +VQLKPR P H ++ + + AVCDY+Q+E+T+ K DEC L +Q + WKV+S +G+E
Sbjct: 926 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 985
Query: 913 AMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQT 972
A VPSVCFL+PPPN++A E +R+E +Q ++ LWHQLHV+ KSL++W LR+D+ L+++
Sbjct: 986 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 1045
Query: 973 WNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHL 1032
W+L R+ P E Q + +L+ HY+ FL+DS+D+ F DRL E E +C +Q L
Sbjct: 1046 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQL 1105
Query: 1033 MKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIA 1092
++S+E +EE+ + ISELK+IRL+LE E R V R++ D++ ++ A RIA
Sbjct: 1106 LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR----LPLDKEPARECAQRIA 1161
Query: 1093 EQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVY 1152
EQ+ Q +++ L + +S + + L S + PTLRSEL L + K++ V LS +Y
Sbjct: 1162 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1221
Query: 1153 LNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNS 1212
L KLKT+ +++R Q AE +++ +E +L + + V A L LEA ++L+ + + +
Sbjct: 1222 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1281
Query: 1213 VFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELES 1272
F L +E+ A+ V E++ + ER++++ER++E+ +QL ERW V+AQ ++RQ ELE
Sbjct: 1282 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341
Query: 1273 IQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTK 1332
+ L YR L W+++ +QE ++ DS+ + EQL Q+ AL EIER+ K
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1401
Query: 1333 LDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRY 1392
+++CQ+F++QY +KDYELQL+TYKA +E SP K+ ++ S S+++ QE++DLRT Y
Sbjct: 1402 VEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPAKKPKVQSGSESVIQEYVDLRTHY 1460
Query: 1393 TALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS 1452
+ L TLT+Q++K+IS+ LRR+EEEE++ E+++ E E++ E+ + L + Q +
Sbjct: 1461 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV---EAALEKQRQLAEAHA 1517
Query: 1453 ETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLN 1512
+ K + E L+Q+ + EE+ ++E +A +++K+ I E+L
Sbjct: 1518 QAKAQAEREAKELQQR-MQEEVVRREEAAVDA----------------QQQKRSIQEELQ 1560
Query: 1513 ALNKAYHDLCDGSANQLQQLQ-SQLAHQTEQKTLQKQQNTCHQQL----EDLCSWVGQAE 1567
L ++ A Q + + S+L + E + ++ Q +Q +L + +AE
Sbjct: 1561 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1620
Query: 1568 RALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPR 1627
A A Q R Q++ L+ + +QD+ Q + + + ++ E + K R
Sbjct: 1621 EAEA--QKRQAQEEAERLR------RQVQDESQRKRQAEVELASRVKAEAEAAREK--QR 1670
Query: 1628 ELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDA 1687
L AL E QA+E E R+ Q E+E A + ET + A EL +
Sbjct: 1671 ALQALEELRLQAEE------AERRLRQAEVERARQVQVALETAQRSAEAELQSKR----- 1719
Query: 1688 LLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKA 1747
S QL +L E ++ A L + A +A E+ +++ E +
Sbjct: 1720 -----ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1773
Query: 1748 RHQELLS---QQQNFILATQSAQAFLDQHGHNL--------TPEEQQMLQQKLGELKEQY 1796
+ E L Q + AQA ++ EEQ + Q++L E + +
Sbjct: 1774 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1833
Query: 1797 STSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLK 1856
LA+ A+ Q + EL + + ++ E + E+EL + + E + K
Sbjct: 1834 QRQLAEGTAQ--QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-----EAAAATQK 1886
Query: 1857 RQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTAL 1916
RQ ++ + ++ + S + + S E K +L+ R+ L
Sbjct: 1887 RQ-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---------KQRLEAEAGRFREL 1936
Query: 1917 HSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLAT 1976
+ RL + L + + Q A Q EA E++L++ +A+ + E
Sbjct: 1937 AEEAARLRA-----LAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAA----IGEATRL 1985
Query: 1977 TKQLQEELAEHQVPVEKLQKVARD----IMEIEGEPAPDHRHVQETTDSILSHFQSLSYS 2032
+ + L E + E+L+++A D +E + A ++E L+ + S S
Sbjct: 1986 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKASDS 2041
Query: 2033 LAER-SSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKL 2091
ER L++ + Q + V+E + +L S E+ GK L G I+ ++
Sbjct: 2042 ELERQKGLVEDTLRQRRQVEEEILALKASF---EKAAAGKAELELELGRIRSNAEDTLR- 2097
Query: 2092 KQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKK 2151
+++++ LEA R+ AA + + E +R ++ ++E K
Sbjct: 2098 ----SKEQAELEAARQ----------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143
Query: 2152 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL 2211
L + E + + ++ E + A Q Q+ Q +E QQ+ +
Sbjct: 2144 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2203
Query: 2212 EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRT 2271
+ L E S L Q + + R+ E ++ + E++A+ + Q++E +L ++
Sbjct: 2204 QTLQQEQSV------LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2257
Query: 2272 FQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIM 2331
+ E + + + + E L+ + A++ E+ + + M
Sbjct: 2258 AE-------------EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2304
Query: 2332 EITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQE 2391
E ++ T + +++ +++ + L+ E+ + E
Sbjct: 2305 EKHKKFAE--------------------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2344
Query: 2392 SLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELE 2451
LQ + E ++ + V + L S ++ + + + + E L+
Sbjct: 2345 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2404
Query: 2452 QNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 2511
+ + K+++V E A L V +QEA +++ EE ++ E + + Q + A+
Sbjct: 2405 EEAEKMKQVAEEAARLSVA---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 2512 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ-KQQVQFMLKEFEARRQQHEQL 2570
L AE++L +KEL L D + Q ++ Q + EA RQ+ ++
Sbjct: 2462 L----KAEAELLQ--QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515
Query: 2571 NEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELL 2630
+ A+ + ++S + ++ +++ Q ++ E+ +KL+ R+ Q
Sbjct: 2516 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELATQ------------ 2562
Query: 2631 QDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV 2690
EKV V Q L +Q S ++ E +E+ + E+L E K Q +E+
Sbjct: 2563 ----EKVTLV-QTLEIQRQQSDHD--AERLREAIAELEREKEKLQQEAKLLQLKSEEMQT 2615
Query: 2691 LIGEQYL-------------KDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQ 2737
+ EQ L KD L +R + LE L D + + Q Q+ Q
Sbjct: 2616 VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2675
Query: 2738 QMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGES 2797
Q ++ R L + + + E + ++ EE Q+ Q E++ E +
Sbjct: 2676 QQMEQERQRLVASMEEARRR-----QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2730
Query: 2798 LLLSVPPGEEKRTLQNQLVELKNHWEELS 2826
L E+ + L+ Q H EE++
Sbjct: 2731 L------REQLQLLEEQHRAALAHSEEVT 2753
Score = 131 bits (329), Expect = 2e-29
Identities = 322/1752 (18%), Positives = 693/1752 (39%), Gaps = 241/1752 (13%)
Query: 2635 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE 2694
E R QR++ Q + E + + + S + L A TL EL + +G+
Sbjct: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1210
Query: 2695 ----QYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750
+ L ++L+T++L ++G + A + + + L Q EL
Sbjct: 1211 LEQVRSLSAIYLEKLKTISLVIRGTQG-AEEVLRAHEEQLKEAQAVPATLPELEATKASL 1269
Query: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810
+ +A+ + L+ +L+ +E + L Q G +V E
Sbjct: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV----------------EVER 1313
Query: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV- 2869
+ ++ +L W+ + +T RQ L+ ++ + Y+ + L W++D + + +++
Sbjct: 1314 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1373
Query: 2870 -TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQN 2928
D + L + +A+L E+E+ +E A IN+ + E + KA + +
Sbjct: 1374 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-EP 1432
Query: 2929 MDAVTEELQAKTGSLEEMTQRLREFQESFKNIE-------KKVEGAKHQLEIFDALGSQA 2981
+ + ++ + ++GS E + Q + + + + K + ++E + L Q
Sbjct: 1433 VASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ- 1490
Query: 2982 CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV 3041
+ E+ EV ALE Q Q + A++E E+
Sbjct: 1491 ---QRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-----------------AEREAKEL 1530
Query: 3042 KQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD-ELDGMGAIGRDTDSLQSQIEDV 3100
+QR+ V E Q ++E QL + E+ + + +IE+
Sbjct: 1531 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1589
Query: 3101 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQ 3160
+I V++L +EA+E + G G + EL+AL + + + + QE+
Sbjct: 1590 -----EIRVVRLQLEATE-------RQRG-----GAEGELQALRARAEEAEAQKRQAQEE 1632
Query: 3161 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPL 3220
E +V+D ++ + + +AEA E + Q L + ++ Q +
Sbjct: 1633 AERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRL----QAEEA 1685
Query: 3221 QMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME-EINARWNTLNKKVAQRIAQLQEALLHC 3279
+ +L+Q +Q A ++ + E E+ ++ + +K AQ LQE +
Sbjct: 1686 ERRLRQAEVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1740
Query: 3280 GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT--VDML 3337
+ ++ E A+ E + AE ++ + Q++ + L+ L + +
Sbjct: 1741 AQLREEAERRAQQQAEAE-----RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1795
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397
QAE + + AE R + G+ E R EL + +Q+QL + A+Q +
Sbjct: 1796 QAEAEKQKEEAEREARRR--GKAEEQAVRQRELAEQELEKQRQLAE--GTAQQRLAAEQE 1851
Query: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKI---GQSLS 3454
+ + TE+ + + + A++Q++ +++E V +++ ++ +
Sbjct: 1852 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1911
Query: 3455 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED----------- 3503
S + +++++ R+ E+ + R AL ++A +L ED
Sbjct: 1912 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1971
Query: 3504 ----------------EVEVLNWLAEVEDKLSSVFVKD--FKQDVLHRQHADHLA-LNEE 3544
E E+ E E++ +D F++ L Q A H A + E
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 2031
Query: 3545 IVNRKKNVDQAIKNGQALLKQT------TGEEVLLIQEKLDGIKTRYADITV-------T 3591
+ +K D ++ + L++ T EE+L ++ + A++ +
Sbjct: 2032 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 2091
Query: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS-GGQSPTGEQIPQFQQRQKEL 3650
+ LR+ EQA A + + E RE EE + S + Q + + L
Sbjct: 2092 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2151
Query: 3651 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA 3710
K +V E R + + + S L+L A+E K + + + V + +
Sbjct: 2152 KAKVEEARRLRERAEQESARQLQL----AQEAAQKRLQAEEKAHAFA-------VQQKEQ 2200
Query: 3711 AIQRSQQYEQAADAELAWVAETKRKLMALGP---IRLEQDQTTAQLQVQKAFSIDIIRHK 3767
+Q++ Q EQ+ +L AE R+ ++ E++ ++ QV++A R K
Sbjct: 2201 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-----ERLK 2255
Query: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKT------ESLIQQYEA--ISLLNSERYAR--- 3816
S +E R++ + +K QE ++ ++Q +A + +++A
Sbjct: 2256 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315
Query: 3817 LERAQV------LVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 3870
++AQV L Q ET + + EE + L A+ A Q+ ++ +R E
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2375
Query: 3871 SIAEHKPHIDK-----LLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALAL 3925
+++ K I+ +L+ + EE E +++ ++A + +E R R LA
Sbjct: 2376 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA- 2434
Query: 3926 DEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEK 3985
+E ++Q + E + + E ++ + R + AE + +++ + A + +
Sbjct: 2435 EEDLAQQRALAE-----KMLKEKMQAVQEATR----LKAEAELLQQ---QKELAQEQARR 2482
Query: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045
LQ E ++ ++L +QG + L A E Q +L ++ A AE +++ ++
Sbjct: 2483 LQ---EDKEQMAQQLAEETQGFQRTLEA-ERQRQL--------EMSAEAERLKLRVAEMS 2530
Query: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105
+ D ++ + +H E +++V +T++ + + E
Sbjct: 2531 RAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEIQRQQSDHDAER 2584
Query: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER-LEKLEDAMQAAVQYQDTL 4164
+R A+L E EK ++++ + E + +E+ L++ + Q+ + +D+L
Sbjct: 2585 LREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2639
Query: 4165 QAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK 4224
+++ KL + +D++ + ++ + E +QQ +ME+ + ++
Sbjct: 2640 LQRERFIEQEKAKLEQL---------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2690
Query: 4225 KA---TDETDRDIIR--EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4279
+A E + + R E L +L+ E +A +L Q Q E+ +
Sbjct: 2691 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR------EQLQLLEEQHRA 2744
Query: 4280 WLTHTEELLDAQ 4291
L H+EE+ +Q
Sbjct: 2745 ALAHSEEVTASQ 2756
Score = 129 bits (325), Expect = 6e-29
Identities = 545/2630 (20%), Positives = 996/2630 (37%), Gaps = 398/2630 (15%)
Query: 1209 DKNSVFSVLD-EEIAKAKVVAEQ---MSRLTPERNLDLERYQEKG-----SQLQERWHRV 1259
D N V+ + E + +A VAE+ ++RL ++D+ + EK S L + RV
Sbjct: 343 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 402
Query: 1260 I-AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKPGQAEDSRVLSEQLS 1317
Q +R +EL+ + +YR L++W+ TA +E P E+ +L Q
Sbjct: 403 PDVQDGVRANELQLRWQ---EYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 459
Query: 1318 QQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSS 1377
+ + E+ + ++ + Q V+ +L++ PG
Sbjct: 460 KFKEM--ELPAKEADKNRSKGIYQSLEGAVQAGQLKV------------PPGYHP----- 500
Query: 1378 SDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGW 1437
+D+ + L + K + RLE +++V + + E +E L
Sbjct: 501 --------LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME-AGLCEEQLNQ 551
Query: 1438 VSTLARN-----TQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFL 1492
L ++ GK + D++KA ++L ++ T K+
Sbjct: 552 ADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD------------- 598
Query: 1493 AKH--GHKLSEKEKKQISEQLNALNKAYH-DLCDGSANQLQQLQSQLAHQTEQKTLQKQQ 1549
+H G ++ + + + E+L A+ Y+ L G A Q+ +Q+ Q+ Q+ + +
Sbjct: 599 GRHPQGEQMYRRVYR-LHERLVAIRTEYNLRLKAGVAAPATQV-AQVTLQSVQRRPELED 656
Query: 1550 NTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATV 1609
+T + L+DL +WV + + + G + DL +++ + L I+
Sbjct: 657 STL-RYLQDLLAWVEENQHRVDGAEWGV---DLPSVEAQLGSHRGLHQSIEEFRAKIERA 712
Query: 1610 VKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
D + +LSP A R+ L + QY L ++ + LE +
Sbjct: 713 RSD--------EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV----- 759
Query: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729
+ A KEL +K + VG TN+ ++ A + + L
Sbjct: 760 --AAATKELMWLNEKEEE------EVGFDWSDRNTNMTAKKESYSALMRELELKEKK-IK 810
Query: 1730 GVNQAPEKL---DKQCEMMKARHQELLSQQQNFIL-------ATQSAQAFLDQHGHNLTP 1779
+ A ++L D Q L Q +++L A A Q ++
Sbjct: 811 ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 870
Query: 1780 EEQQMLQQKLGE-LKEQYSTSLAQSEAELKQV-QTLQDELQKFLQDHKEFESWLERSEK- 1836
E Q+ QKL E L+ +YS + + L+ + Q QDE ++ L ++K S L + K
Sbjct: 871 AEGQL--QKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ-LNEYKGHLSGLAKRAKA 927
Query: 1837 --ELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQ----KVLDMENSFK 1890
+L+ H LP LL +V HKGD + Q KVL S
Sbjct: 928 VVQLKPRHPAHPMRGRLP-LLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-- 984
Query: 1891 EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950
E PS + LV ++A E T RL + L+ +HQ SL AW Q+
Sbjct: 985 EAAVPS-VCFLVPPPNQEAQEAVT-------RLEAQHQALVTLWHQLHVDMKSLLAW-QS 1035
Query: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010
+V+ + S ++A+ T K ++ A H + + Q RD + G
Sbjct: 1036 LRRDVQLIRSWSLAT--------FRTLKPEEQRQALHSLELH-YQAFLRDSQDAGGFGPE 1086
Query: 2011 DHRHVQETTDSILSHFQSLSYSL---AERSSLLQKAIAQSQSVQESLESL-LQSIGEVEQ 2066
D + S H+Q L SL A+ S Q+ I++ + ++ LE+ +++ +
Sbjct: 1087 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1146
Query: 2067 NLEGKQVSSLSSGVI--QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2124
L+ + + + Q+A A L + +AR L A E V E S A L
Sbjct: 1147 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR----LSAEAEKVLALPEP--SPAAPTL 1200
Query: 2125 QGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2181
+ +L + EQ L EK ++ ++ + E + ++ ++ + A+
Sbjct: 1201 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT-- 1258
Query: 2182 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---------DLCQHQD 2232
P+ + T +++L + E QQ D L + G L ++ + ++
Sbjct: 1259 LPELEATK--ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1316
Query: 2233 RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSA 2292
RV L + + + R+++ QL +R+ WL++ + A
Sbjct: 1317 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1376
Query: 2293 --KELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME-----ITAPDSQGKTGSI 2345
+ + +Q+ ++LL++ G VEE N I + +T S
Sbjct: 1377 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1436
Query: 2346 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2405
GS + DL +++ + +Y K R E + + + +
Sbjct: 1437 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1496
Query: 2406 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2465
E + ++ K+ L A + K + + + E+ + Q+ K ++
Sbjct: 1497 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556
Query: 2466 GLLVTYPNSQEAENWKKIQE----------------------------------ELNSRW 2491
L S EAE K ++ EL +
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1616
Query: 2492 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 2551
RA E A++RQ +E A L ESQ R E EL V A +
Sbjct: 1617 ARAEEAE-AQKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQA 1674
Query: 2552 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ--VQKELQSINQKWVELTDKL 2609
+ L+ EA R+ + E A+ + V+L T+Q + ELQS + E T +L
Sbjct: 1675 LEELRLQAEEAERRLRQAEVERARQV-----QVALETAQRSAEAELQSKRASFAEKTAQL 1729
Query: 2610 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRS 2669
RS Q + V L++ +E+ RA Q + ++ + E + QL+ +R
Sbjct: 1730 E-RSLQEEHVAVAQ------LREEAER-RAQQQAEAERAREEAERELERWQLKANEALRL 1781
Query: 2670 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK-RLETVALPLQGLEDLAADRINRLQA 2728
L+ EV + ++L + E+ ++ ++ + E A+ + L + ++ +L
Sbjct: 1782 RLQA--EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1839
Query: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQL----QENEEFQKSLNQH 2784
A Q+ + +R + +Q +Q + + +L RLQ + Q+ +E + L +
Sbjct: 1840 GTAQ-QRLAAEQELIRLRAETEQGEQQRQL-LEEELARLQREAAAATQKRQELEAELAKV 1897
Query: 2785 SGSYEVIVA-----EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK-----KTADRQS 2834
EV++A E ES S + K+ L+ + + EE ++ + A RQ
Sbjct: 1898 RAEMEVLLASKARAEEESRSTSE---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1954
Query: 2835 RLKD---CMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVE 2891
+L + Q+A+ + E L E + K +E + L + E+ LR A +
Sbjct: 1955 QLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQ 2013
Query: 2892 KRRSLLEILNSAADI---LINSSEADEDGIRDEKAGINQNMDA---VTEELQAKTGSLEE 2945
+RR + ADI L +A + + +K + + V EE+ A S E+
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 2073
Query: 2946 MTQRLREFQESFKNIEKKVEG---AKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
E + I E +K Q E+ A Q + + + A++ V ++L
Sbjct: 2074 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133
Query: 3003 QVDYLRNFTQGLVEDA---PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG- 3058
+ + R L E +A +L +AE L++ Q + E K
Sbjct: 2134 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2193
Query: 3059 -IGQFHCRVREMFSQLADLDDELDGMGAIGR-------------DTDSLQS--QIEDVRL 3102
+ Q +++ Q + D+L G R + ++ QS Q+E+
Sbjct: 2194 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2253
Query: 3103 FLNKIH------------VLKLDIEASEAECRHMLEEEGTL-DLLGLKRELEALNKQCGK 3149
KL EA + R E+ L E+E +K+ +
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-HKKFAE 2312
Query: 3150 LTERGKARQEQLELTLGRVE----DFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
T R KA+ EQ ELT R++ D + L AE EA + E E+ + +
Sbjct: 2313 QTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371
Query: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265
+ Q E++ L+ +++ N + LI KD + L+ + E++ K+V
Sbjct: 2372 V------QMEELSKLKARIEAEN---RALILR-DKDNTQRFLQEEAEKM--------KQV 2413
Query: 3266 AQRIAQLQEALLHCGKFQD-ALEPLLSWLADTEELIANQKPPSAEYKVVKAQ---IQEQK 3321
A+ A+L A + + A E L A E+++ + E +KA+ +Q+QK
Sbjct: 2414 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2473
Query: 3322 LL-----QRLLDDRKATVDML--QAEGGRIAQSAELADREKITGQLESLESRWTELLSKA 3374
L +RL +D++ L + +G + AE + +++ + E L+ R E+ S+A
Sbjct: 2474 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRA 2532
Query: 3375 AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKA-- 3431
AR + ED A++F + AE I + L TE LA E V QT +IQ+Q H A
Sbjct: 2533 QARAE--ED----AQRFRKQAEEIGEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAER 2584
Query: 3432 LEE---DIENHATDVHQAVKIGQ------------SLSSLTSPAEQGVLSEKIDSLQARY 3476
L E ++E + Q K+ Q L T +Q LSEK DSL R
Sbjct: 2585 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-DSLLQRE 2643
Query: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEV------------------------------- 3505
I+ + L ++ A+ E++
Sbjct: 2644 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2703
Query: 3506 ----EVLNWLAEVEDKLSSVFVKDFKQ-----DVLHRQHADHLALNEEIVNRKKNVDQAI 3556
E L L + + + ++ ++ +L QH LA +EE+ + + +
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2763
Query: 3557 KNGQALLKQTTGEEVLLIQEKLDGIK-----TRYADITVTSSKALRTLEQ 3601
NG+ L E + DG++ R + + S++ L+ L Q
Sbjct: 2764 PNGRDALDGPAAEAE--PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2811
Score = 100 bits (249), Expect = 4e-20
Identities = 318/1624 (19%), Positives = 619/1624 (38%), Gaps = 261/1624 (16%)
Query: 3221 QMKLQ-QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC 3279
Q K Q +V GLG+G+ + + + V L E + TL ++ + +L++
Sbjct: 1163 QQKAQAEVEGLGKGVARLSAEAEKVLALP----EPSPAAPTLRSELELTLGKLEQVRSLS 1218
Query: 3280 GKFQDALEPLLSWLADT---EELIANQKPPSAEYKVVKAQIQEQ-------KLLQRLLDD 3329
+ + L+ + + T EE++ + E + V A + E K L+ +
Sbjct: 1219 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1278
Query: 3330 RKATVDMLQAE-------GGRIAQSAELAD------REKITGQLESLESRWTELLSKAAA 3376
++ T D L+ E G R+ Q D RE++ LE RW +L++
Sbjct: 1279 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE----RWQAVLAQTDV 1334
Query: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKALEED 3435
RQ++LE + + + E+A+P+ +L ++ + + + +++Q+ + +AL E+
Sbjct: 1335 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1394
Query: 3436 IENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495
IE H V + + A+Q + + K LQ + Q A + S
Sbjct: 1395 IERHGEKVEECQRF----------AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1444
Query: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD-Q 3554
+ ++ V++ +E+ L+S ++K + + + + LA + R++ + +
Sbjct: 1445 GSESVIQEYVDLRTHYSEL-TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503
Query: 3555 AIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 3614
A Q L + + + + ++ R + V +A +Q + +S E
Sbjct: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK------RSIQE 1557
Query: 3615 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLD-TVNEVSRALLE 3673
EL + E E+ Q+ E + + +++E+ RL L+ T + A E
Sbjct: 1558 ELQQLRQSSEAEIQAKARQAEAAE------RSRLRIEEEIRVVRLQLEATERQRGGAEGE 1611
Query: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----QAADAELAWV 3729
L RAR +A Q + + + ++ QR +Q E AE
Sbjct: 1612 LQALRAR------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1665
Query: 3730 AETKRKLMALGPIRL---EQDQTTAQLQVQKAFSIDI---IRHKDSMDELFSHRSEIFGT 3783
E +R L AL +RL E ++ Q +V++A + + + + EL S R+
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF--- 1722
Query: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW-IEETR 3842
+KT E+ SL +++ A++ L E R ++ E EL W ++
Sbjct: 1723 ---AEKTAQLER--SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1777
Query: 3843 ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902
AL +L + + ++ Q E +Q E+ E + + +E + E+ E+
Sbjct: 1778 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------GKAEEQAVRQRELAEQ 1829
Query: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962
+ +K Q+ E Q+ LA ++ + + TE ++ +LE E L+ R+
Sbjct: 1830 ELEKQR----QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE--EELA---RLQREA 1880
Query: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4022
A K +E ++ E+E L S K R EE RS + + +
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLAS----KARAEE-ESRSTSEKSKQRLEAEAGRFRE 1935
Query: 4023 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4082
+ ++A AEE + + +LAE+ A + + + L + G + + +
Sbjct: 1936 LAEEAARLRALAEEAKRQ----RQLAEE-----DAARQRAEAERVLAEKLAAIG-EATRL 1985
Query: 4083 KQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT 4142
K + E A KE E E +R L D F E+ + D + L K
Sbjct: 1986 KTEAEIALKEKE------AENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKA 2038
Query: 4143 WKERLEK----LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP-PVGTDLNTVKDQLNE 4197
LE+ +ED ++ Q ++ + A+ + + +G + +D L
Sbjct: 2039 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098
Query: 4198 MKEFKVEVYQQQ---IEMEKLNHQGELMLKK--ATDETDRDIIREPLTELKHLWENLGE- 4251
++ ++E +Q+ E E+ + E ++K A +E + L E++ L + E
Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158
Query: 4252 -KIAHRQHKLEGALLALGQ-----------------FQHALEELMSWLTHTEELLDAQRP 4293
++ R + L L Q Q +EL L + +LD R
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2218
Query: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN----ELLESSAGDDASSLRSRLE 4349
E E A+ + + QA E E L+ SA + A +
Sbjct: 2219 --------EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2270
Query: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE--------------DFLLELTRMES 4395
A + + Q+ R Q Q+ L+Q Q +E+E ELT +
Sbjct: 2271 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2330
Query: 4396 QLSASKPTGGL------------PETAREQLDTHMELY---------SQLKAKEETYNQL 4434
QL + L E AR++ EL+ S+LKA+ E N+
Sbjct: 2331 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2390
Query: 4435 L---DKGRLMLLSRDDSGSGSKTEQSVALLE------------------QKWHVVSSKME 4473
L DK ++++ + + A L Q+ + ++
Sbjct: 2391 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2450
Query: 4474 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI-----EEHK 4528
E+ ++EA L E + L +Q +A + L Q+ EE +
Sbjct: 2451 EKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2499
Query: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588
F + A R + +E+ +LK + + Q+R E+ QR ++ +
Sbjct: 2500 GFQRTLEAERQRQLEMSAEAERLKLRVAE---------MSRAQARAEEDAQRFRKQAEEI 2550
Query: 4589 DDARKRAKQFHEAWKKLIDWLE--------DAESHLDSELEISNDPDKIKLQ---LSKHK 4637
+ R + + L+ LE DAE ++ E+ + +K++ + L
Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2610
Query: 4638 EFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDS-QKLDNFLGEVRDKWDTVCGKSVERQH 4696
E +T+ +Q + +T +AL++ L +DS + + F+ + + K + + V +
Sbjct: 2611 EEMQTVQQEQLLQET-----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2665
Query: 4697 KLEE 4700
+L E
Sbjct: 2666 QLRE 2669
Score = 67.0 bits (162), Expect = 5e-10
Identities = 235/1255 (18%), Positives = 480/1255 (38%), Gaps = 105/1255 (8%)
Query: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 3922
EE RQ S+ + H L+ PE+ M E +Y + Y Q+ + + Q A
Sbjct: 1057 EEQRQALHSL---ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGA 1113
Query: 3923 LALDEAVSQSTQITEFHDKIEPMLETLENLS-SRLRMPPLIPAEVDKIREC---ISDNKS 3978
E I+E D I LE E + RLR +P + + REC I++ +
Sbjct: 1114 ---QEESRCQRCISELKD-IRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQK 1165
Query: 3979 ATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038
A E+E L L E+++ + + AA ++ +L+ + E +++
Sbjct: 1166 AQAEVEGLGKGVARLSAEAEKVLALPEPSP---AAPTLRSELELTLGKLEQVRS-LSAIY 1221
Query: 4039 IKFLDVLELAEKFWYDMAALLTT----IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094
++ L + L + +L +K+ Q + L + +K+ AE +
Sbjct: 1222 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1281
Query: 4095 ETDGLHEELEFIRILGADLIFACGE--TEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152
D L +EL + +G L GE E R+ + ++ W+ + R +LE
Sbjct: 1282 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341
Query: 4153 AMQAAVQYQDTLQAMFDWLDNT---VIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQ-- 4207
+ Y+++ + WL + ++ MP D V++QL + + E+ +
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL--ADSQAVREQLRQEQALLEEIERHG 1399
Query: 4208 ------QQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN---LGEKIAHRQH 4258
Q+ + +N + L+ T + + + P + K + + E + R H
Sbjct: 1400 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1459
Query: 4259 KLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--------LAKHHV 4310
E L Q+ + E + + E L + QR + ++ EVE LA+ H
Sbjct: 1460 YSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHA 1517
Query: 4311 LKNDVLAHQATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4368
+ A + E + E++ E +A D RS E + Q +S + + + +Q
Sbjct: 1518 -QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1576
Query: 4369 LQSTLQQAQGFHSEIEDFLLELTRMESQLSAS----KPTGGLPETAREQLDTHMELYSQL 4424
++ + EI L+L E Q + + E A Q E +L
Sbjct: 1577 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1636
Query: 4425 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA-L 4483
+ + + +Q + + L SR + + + E+ AL Q + + EE + +L +A +
Sbjct: 1637 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEV 1694
Query: 4484 NLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA---NEVNAHRDQ 4540
A + Q +L E AE AS S EEH A E Q
Sbjct: 1695 ERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753
Query: 4541 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI---ERGRSLDDARKRAKQ 4597
E ++ + + ++ + + L + +Q+ E Q+S+ E + ++A + A++
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARR 1812
Query: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH--KEFQKTLGGKQPVYDTTIR 4655
+A ++ + E AE L+ + +++ + +L + + +T G+Q
Sbjct: 1813 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1872
Query: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
R +E + Q+L+ L +VR + + + + EE+ S + L+A
Sbjct: 1873 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAE 1929
Query: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775
++ + A + + Q++L + Q R E
Sbjct: 1930 AGRFRELAEEAAR-----------LRALAEEAKRQRQLAEEDAARQ------RAEAERVL 1972
Query: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF--RDTVHMLLEWLSEAEQT 4833
+ G+ L T + K ++ RL + L + E F R + ++ E+
Sbjct: 1973 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 2031
Query: 4834 L-RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKH 4892
L + R A + E + L++ ++VEE+ + + ++ A + +
Sbjct: 2032 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 2091
Query: 4893 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIP 4952
+R++ + L A+Q Q E A + + L A + A R ++
Sbjct: 2092 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA------RQRKAAL 2145
Query: 4953 QNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI---EPTHAPFIEKSRSGGRKS 5009
+ ++R+KA + E + E ++ ++ + +K + E HA +++ +++
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2205
Query: 5010 LSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064
L Q + ++EA + Q A + +R++ +A +RL++ E
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAE 2259
Score = 39.7 bits (91), Expect = 0.082
Identities = 26/54 (48%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 5350 SASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRR 5403
S S GS AGSR GSR SR GS FD T S S T SS+ G RR
Sbjct: 4616 SVSGSGSTAGSRTGSRTGSRAGSRRGSFD--ATGSGFSMTFSSSSYSSSGYGRR 4667
Score = 34.3 bits (77), Expect = 3.5
Identities = 49/247 (19%), Positives = 98/247 (39%), Gaps = 25/247 (10%)
Query: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635
+V +S++R L+D+ R Q L+ W+E+ + +D E D ++ QL
Sbjct: 642 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 694
Query: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEK-TLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
H+ G Q + + + RA ++ L P + LG + ++ + S R
Sbjct: 695 HR------GLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 748
Query: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLM---DAHKVFQK 4751
LE F+ A + WL + E E++ D N+ +++ +
Sbjct: 749 LRSLESL----HSFVAAATKELMWLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMR 800
Query: 4752 ELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALK 4811
EL + ++ L+ +G L+ V+ L T+W + +L ++ L++
Sbjct: 801 ELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAA 860
Query: 4812 QAEVFRD 4818
+ F D
Sbjct: 861 YFQFFSD 867
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 1378 bits (3566), Expect = 0.0
Identities = 922/2789 (33%), Positives = 1482/2789 (53%), Gaps = 246/2789 (8%)
Query: 74 DERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRF 133
DERDRVQKKTFTKWVNKHL+K ++HI+DLYEDLRDGHNLISLLEVLSG LPREKGRMRF
Sbjct: 24 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 83
Query: 134 HRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGD 193
H+LQNVQIALD+L+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI +SG+S D
Sbjct: 84 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 143
Query: 194 MSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRE 253
M+AKEKLLLW+Q++ GY G++C NF+S W DG++FNA+IHR++P L+DM +V Q+N E
Sbjct: 144 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 203
Query: 254 NLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEV 312
NL+QAF VAER LGVTRLLD EDVDVP PDEKS+ITYVSS+YDA P+VP+ +G+ A E+
Sbjct: 204 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 263
Query: 313 DSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKG 372
RWQEY+ V L+ W++ HT ++ FP + E++ L++Q++ FKE E+ AKE +K
Sbjct: 264 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 323
Query: 373 RIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQI 432
R + +Y+ LE ++ G++K+P GYHP DVE+EWGKL + +LEREK LR ERLE L +I
Sbjct: 324 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 383
Query: 433 ANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQ 492
K+Q A CEE+L A LQ+D L +G+ Q +V + + + +IR L D+Q
Sbjct: 384 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 443
Query: 493 ILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEP 552
L+D + Q E++ RV RL + LV +R E + G A P
Sbjct: 444 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG------------------VAAP 485
Query: 553 LTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDL 612
T+ + S R+P EL ++ LR++ +LL+WVEE Q +++ AEWG DL
Sbjct: 486 ATQVAQVTLQSVQRRP----EL-------EDSTLRYLQDLLAWVEENQHRVDGAEWGVDL 534
Query: 613 PSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETS 672
PSVE QL + + +H S+EE + ++ AR EG++S +Y + LG+L+ QY KL +S
Sbjct: 535 PSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSS 594
Query: 673 SFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEK 732
R+R L+SLH FV+ AT EL+WLNEKEEEE+ +DWSD N+N++AK+ +S L ELE K
Sbjct: 595 KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 654
Query: 733 QDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFF 792
+ + LQ+ + L E+HPA+ TVE++ AA+Q+Q WM QLC C+E H+KEN AYFQFF
Sbjct: 655 EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFF 714
Query: 793 SDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRS 852
SD RE E L+ LQ++++RKYSCD + +++RLEDLLQD+ DEKEQL + K ++ L R+
Sbjct: 715 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 774
Query: 853 KTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNE 912
K +VQLKPR P H ++ + + AVCDY+Q+E+T+ K DEC L +Q + WKV+S +G+E
Sbjct: 775 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 834
Query: 913 AMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQT 972
A VPSVCFL+PPPN++A E +R+E +Q ++ LWHQLHV+ KSL++W LR+D+ L+++
Sbjct: 835 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 894
Query: 973 WNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHL 1032
W+L R+ P E Q + +L+ HY+ FL+DS+D+ F DRL E E +C +Q L
Sbjct: 895 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQL 954
Query: 1033 MKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIA 1092
++S+E +EE+ + ISELK+IRL+LE E R V R++ D++ ++ A RIA
Sbjct: 955 LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR----LPLDKEPARECAQRIA 1010
Query: 1093 EQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVY 1152
EQ+ Q +++ L + +S + + L S + PTLRSEL L + K++ V LS +Y
Sbjct: 1011 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1070
Query: 1153 LNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNS 1212
L KLKT+ +++R Q AE +++ +E +L + + V A L LEA ++L+ + + +
Sbjct: 1071 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1130
Query: 1213 VFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELES 1272
F L +E+ A+ V E++ + ER++++ER++E+ +QL ERW V+AQ ++RQ ELE
Sbjct: 1131 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190
Query: 1273 IQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTK 1332
+ L YR L W+++ +QE ++ DS+ + EQL Q+ AL EIER+ K
Sbjct: 1191 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1250
Query: 1333 LDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRY 1392
+++CQ+F++QY +KDYELQL+TYKA +E SP K+ ++ S S+++ QE++DLRT Y
Sbjct: 1251 VEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPAKKPKVQSGSESVIQEYVDLRTHY 1309
Query: 1393 TALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS 1452
+ L TLT+Q++K+IS+ LRR+EEEE++ E+++ E E++ E+ + L + Q +
Sbjct: 1310 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV---EAALEKQRQLAEAHA 1366
Query: 1453 ETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLN 1512
+ K + E L+Q+ + EE+ ++E +A +++K+ I E+L
Sbjct: 1367 QAKAQAEREAKELQQR-MQEEVVRREEAAVDA----------------QQQKRSIQEELQ 1409
Query: 1513 ALNKAYHDLCDGSANQLQQLQ-SQLAHQTEQKTLQKQQNTCHQQL----EDLCSWVGQAE 1567
L ++ A Q + + S+L + E + ++ Q +Q +L + +AE
Sbjct: 1410 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1469
Query: 1568 RALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPR 1627
A A Q R Q++ L+ + +QD+ Q + + + ++ E + K R
Sbjct: 1470 EAEA--QKRQAQEEAERLR------RQVQDESQRKRQAEVELASRVKAEAEAAREK--QR 1519
Query: 1628 ELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDA 1687
L AL E QA+E E R+ Q E+E A + ET + A EL +
Sbjct: 1520 ALQALEELRLQAEE------AERRLRQAEVERARQVQVALETAQRSAEAELQSKR----- 1568
Query: 1688 LLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKA 1747
S QL +L E ++ A L + A +A E+ +++ E +
Sbjct: 1569 -----ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1622
Query: 1748 RHQELLS---QQQNFILATQSAQAFLDQHGHNL--------TPEEQQMLQQKLGELKEQY 1796
+ E L Q + AQA ++ EEQ + Q++L E + +
Sbjct: 1623 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1682
Query: 1797 STSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLK 1856
LA+ A+ Q + EL + + ++ E + E+EL + + E + K
Sbjct: 1683 QRQLAEGTAQ--QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-----EAAAATQK 1735
Query: 1857 RQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTAL 1916
RQ ++ + ++ + S + + S E K +L+ R+ L
Sbjct: 1736 RQ-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---------KQRLEAEAGRFREL 1785
Query: 1917 HSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLAT 1976
+ RL + L + + Q A Q EA E++L++ +A+ + E
Sbjct: 1786 AEEAARLRA-----LAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAA----IGEATRL 1834
Query: 1977 TKQLQEELAEHQVPVEKLQKVARD----IMEIEGEPAPDHRHVQETTDSILSHFQSLSYS 2032
+ + L E + E+L+++A D +E + A ++E L+ + S S
Sbjct: 1835 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKASDS 1890
Query: 2033 LAER-SSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKL 2091
ER L++ + Q + V+E + +L S E+ GK L G I+ ++
Sbjct: 1891 ELERQKGLVEDTLRQRRQVEEEILALKASF---EKAAAGKAELELELGRIRSNAEDTLR- 1946
Query: 2092 KQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKK 2151
+++++ LEA R+ AA + + E +R ++ ++E K
Sbjct: 1947 ----SKEQAELEAARQ----------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1992
Query: 2152 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL 2211
L + E + + ++ E + A Q Q+ Q +E QQ+ +
Sbjct: 1993 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2052
Query: 2212 EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRT 2271
+ L E S L Q + + R+ E ++ + E++A+ + Q++E +L ++
Sbjct: 2053 QTLQQEQSV------LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2106
Query: 2272 FQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIM 2331
+ E + + + + E L+ + A++ E+ + + M
Sbjct: 2107 AE-------------EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2153
Query: 2332 EITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQE 2391
E ++ T + +++ +++ + L+ E+ + E
Sbjct: 2154 EKHKKFAE--------------------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2193
Query: 2392 SLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELE 2451
LQ + E ++ + V + L S ++ + + + + E L+
Sbjct: 2194 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2253
Query: 2452 QNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 2511
+ + K+++V E A L V +QEA +++ EE ++ E + + Q + A+
Sbjct: 2254 EEAEKMKQVAEEAARLSVA---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 2512 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ-KQQVQFMLKEFEARRQQHEQL 2570
L AE++L +KEL L D + Q ++ Q + EA RQ+ ++
Sbjct: 2311 L----KAEAELLQ--QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2364
Query: 2571 NEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELL 2630
+ A+ + ++S + ++ +++ Q ++ E+ +KL+ R+ Q
Sbjct: 2365 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELATQ------------ 2411
Query: 2631 QDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV 2690
EKV V Q L +Q S ++ E +E+ + E+L E K Q +E+
Sbjct: 2412 ----EKVTLV-QTLEIQRQQSDHD--AERLREAIAELEREKEKLQQEAKLLQLKSEEMQT 2464
Query: 2691 LIGEQYL-------------KDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQ 2737
+ EQ L KD L +R + LE L D + + Q Q+ Q
Sbjct: 2465 VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2524
Query: 2738 QMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGES 2797
Q ++ R L + + + E + ++ EE Q+ Q E++ E +
Sbjct: 2525 QQMEQERQRLVASMEEARRR-----QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2579
Query: 2798 LLLSVPPGEEKRTLQNQLVELKNHWEELS 2826
L E+ + L+ Q H EE++
Sbjct: 2580 L------REQLQLLEEQHRAALAHSEEVT 2602
Score = 131 bits (329), Expect = 2e-29
Identities = 322/1752 (18%), Positives = 693/1752 (39%), Gaps = 241/1752 (13%)
Query: 2635 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE 2694
E R QR++ Q + E + + + S + L A TL EL + +G+
Sbjct: 1000 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1059
Query: 2695 ----QYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750
+ L ++L+T++L ++G + A + + + L Q EL
Sbjct: 1060 LEQVRSLSAIYLEKLKTISLVIRGTQG-AEEVLRAHEEQLKEAQAVPATLPELEATKASL 1118
Query: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810
+ +A+ + L+ +L+ +E + L Q G +V E
Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV----------------EVER 1162
Query: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV- 2869
+ ++ +L W+ + +T RQ L+ ++ + Y+ + L W++D + + +++
Sbjct: 1163 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1222
Query: 2870 -TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQN 2928
D + L + +A+L E+E+ +E A IN+ + E + KA + +
Sbjct: 1223 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-EP 1281
Query: 2929 MDAVTEELQAKTGSLEEMTQRLREFQESFKNIE-------KKVEGAKHQLEIFDALGSQA 2981
+ + ++ + ++GS E + Q + + + + K + ++E + L Q
Sbjct: 1282 VASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ- 1339
Query: 2982 CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV 3041
+ E+ EV ALE Q Q + A++E E+
Sbjct: 1340 ---QRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-----------------AEREAKEL 1379
Query: 3042 KQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD-ELDGMGAIGRDTDSLQSQIEDV 3100
+QR+ V E Q ++E QL + E+ + + +IE+
Sbjct: 1380 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1438
Query: 3101 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQ 3160
+I V++L +EA+E + G G + EL+AL + + + + QE+
Sbjct: 1439 -----EIRVVRLQLEATE-------RQRG-----GAEGELQALRARAEEAEAQKRQAQEE 1481
Query: 3161 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPL 3220
E +V+D ++ + + +AEA E + Q L + ++ Q +
Sbjct: 1482 AERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRL----QAEEA 1534
Query: 3221 QMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME-EINARWNTLNKKVAQRIAQLQEALLHC 3279
+ +L+Q +Q A ++ + E E+ ++ + +K AQ LQE +
Sbjct: 1535 ERRLRQAEVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1589
Query: 3280 GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT--VDML 3337
+ ++ E A+ E + AE ++ + Q++ + L+ L + +
Sbjct: 1590 AQLREEAERRAQQQAEAE-----RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1644
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397
QAE + + AE R + G+ E R EL + +Q+QL + A+Q +
Sbjct: 1645 QAEAEKQKEEAEREARRR--GKAEEQAVRQRELAEQELEKQRQLAE--GTAQQRLAAEQE 1700
Query: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKI---GQSLS 3454
+ + TE+ + + + A++Q++ +++E V +++ ++ +
Sbjct: 1701 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1760
Query: 3455 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED----------- 3503
S + +++++ R+ E+ + R AL ++A +L ED
Sbjct: 1761 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1820
Query: 3504 ----------------EVEVLNWLAEVEDKLSSVFVKD--FKQDVLHRQHADHLA-LNEE 3544
E E+ E E++ +D F++ L Q A H A + E
Sbjct: 1821 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1880
Query: 3545 IVNRKKNVDQAIKNGQALLKQT------TGEEVLLIQEKLDGIKTRYADITV-------T 3591
+ +K D ++ + L++ T EE+L ++ + A++ +
Sbjct: 1881 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1940
Query: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS-GGQSPTGEQIPQFQQRQKEL 3650
+ LR+ EQA A + + E RE EE + S + Q + + L
Sbjct: 1941 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2000
Query: 3651 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA 3710
K +V E R + + + S L+L A+E K + + + V + +
Sbjct: 2001 KAKVEEARRLRERAEQESARQLQL----AQEAAQKRLQAEEKAHAFA-------VQQKEQ 2049
Query: 3711 AIQRSQQYEQAADAELAWVAETKRKLMALGP---IRLEQDQTTAQLQVQKAFSIDIIRHK 3767
+Q++ Q EQ+ +L AE R+ ++ E++ ++ QV++A R K
Sbjct: 2050 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-----ERLK 2104
Query: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKT------ESLIQQYEA--ISLLNSERYAR--- 3816
S +E R++ + +K QE ++ ++Q +A + +++A
Sbjct: 2105 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164
Query: 3817 LERAQV------LVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 3870
++AQV L Q ET + + EE + L A+ A Q+ ++ +R E
Sbjct: 2165 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2224
Query: 3871 SIAEHKPHIDK-----LLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALAL 3925
+++ K I+ +L+ + EE E +++ ++A + +E R R LA
Sbjct: 2225 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA- 2283
Query: 3926 DEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEK 3985
+E ++Q + E + + E ++ + R + AE + +++ + A + +
Sbjct: 2284 EEDLAQQRALAE-----KMLKEKMQAVQEATR----LKAEAELLQQ---QKELAQEQARR 2331
Query: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045
LQ E ++ ++L +QG + L A E Q +L ++ A AE +++ ++
Sbjct: 2332 LQ---EDKEQMAQQLAEETQGFQRTLEA-ERQRQL--------EMSAEAERLKLRVAEMS 2379
Query: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105
+ D ++ + +H E +++V +T++ + + E
Sbjct: 2380 RAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEIQRQQSDHDAER 2433
Query: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER-LEKLEDAMQAAVQYQDTL 4164
+R A+L E EK ++++ + E + +E+ L++ + Q+ + +D+L
Sbjct: 2434 LREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2488
Query: 4165 QAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK 4224
+++ KL + +D++ + ++ + E +QQ +ME+ + ++
Sbjct: 2489 LQRERFIEQEKAKLEQL---------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2539
Query: 4225 KA---TDETDRDIIR--EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4279
+A E + + R E L +L+ E +A +L Q Q E+ +
Sbjct: 2540 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR------EQLQLLEEQHRA 2593
Query: 4280 WLTHTEELLDAQ 4291
L H+EE+ +Q
Sbjct: 2594 ALAHSEEVTASQ 2605
Score = 129 bits (325), Expect = 6e-29
Identities = 545/2630 (20%), Positives = 996/2630 (37%), Gaps = 398/2630 (15%)
Query: 1209 DKNSVFSVLD-EEIAKAKVVAEQ---MSRLTPERNLDLERYQEKG-----SQLQERWHRV 1259
D N V+ + E + +A VAE+ ++RL ++D+ + EK S L + RV
Sbjct: 192 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 251
Query: 1260 I-AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKPGQAEDSRVLSEQLS 1317
Q +R +EL+ + +YR L++W+ TA +E P E+ +L Q
Sbjct: 252 PDVQDGVRANELQLRWQ---EYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 308
Query: 1318 QQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSS 1377
+ + E+ + ++ + Q V+ +L++ PG
Sbjct: 309 KFKEM--ELPAKEADKNRSKGIYQSLEGAVQAGQLKV------------PPGYHP----- 349
Query: 1378 SDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGW 1437
+D+ + L + K + RLE +++V + + E +E L
Sbjct: 350 --------LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME-AGLCEEQLNQ 400
Query: 1438 VSTLARN-----TQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFL 1492
L ++ GK + D++KA ++L ++ T K+
Sbjct: 401 ADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD------------- 447
Query: 1493 AKH--GHKLSEKEKKQISEQLNALNKAYH-DLCDGSANQLQQLQSQLAHQTEQKTLQKQQ 1549
+H G ++ + + + E+L A+ Y+ L G A Q+ +Q+ Q+ Q+ + +
Sbjct: 448 GRHPQGEQMYRRVYR-LHERLVAIRTEYNLRLKAGVAAPATQV-AQVTLQSVQRRPELED 505
Query: 1550 NTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATV 1609
+T + L+DL +WV + + + G + DL +++ + L I+
Sbjct: 506 STL-RYLQDLLAWVEENQHRVDGAEWGV---DLPSVEAQLGSHRGLHQSIEEFRAKIERA 561
Query: 1610 VKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
D + +LSP A R+ L + QY L ++ + LE +
Sbjct: 562 RSD--------EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV----- 608
Query: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729
+ A KEL +K + VG TN+ ++ A + + L
Sbjct: 609 --AAATKELMWLNEKEEE------EVGFDWSDRNTNMTAKKESYSALMRELELKEKK-IK 659
Query: 1730 GVNQAPEKL---DKQCEMMKARHQELLSQQQNFIL-------ATQSAQAFLDQHGHNLTP 1779
+ A ++L D Q L Q +++L A A Q ++
Sbjct: 660 ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 719
Query: 1780 EEQQMLQQKLGE-LKEQYSTSLAQSEAELKQV-QTLQDELQKFLQDHKEFESWLERSEK- 1836
E Q+ QKL E L+ +YS + + L+ + Q QDE ++ L ++K S L + K
Sbjct: 720 AEGQL--QKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ-LNEYKGHLSGLAKRAKA 776
Query: 1837 --ELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQ----KVLDMENSFK 1890
+L+ H LP LL +V HKGD + Q KVL S
Sbjct: 777 VVQLKPRHPAHPMRGRLP-LLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-- 833
Query: 1891 EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950
E PS + LV ++A E T RL + L+ +HQ SL AW Q+
Sbjct: 834 EAAVPS-VCFLVPPPNQEAQEAVT-------RLEAQHQALVTLWHQLHVDMKSLLAW-QS 884
Query: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010
+V+ + S ++A+ T K ++ A H + + Q RD + G
Sbjct: 885 LRRDVQLIRSWSLAT--------FRTLKPEEQRQALHSLELH-YQAFLRDSQDAGGFGPE 935
Query: 2011 DHRHVQETTDSILSHFQSLSYSL---AERSSLLQKAIAQSQSVQESLESL-LQSIGEVEQ 2066
D + S H+Q L SL A+ S Q+ I++ + ++ LE+ +++ +
Sbjct: 936 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 995
Query: 2067 NLEGKQVSSLSSGVI--QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2124
L+ + + + Q+A A L + +AR L A E V E S A L
Sbjct: 996 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR----LSAEAEKVLALPEP--SPAAPTL 1049
Query: 2125 QGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2181
+ +L + EQ L EK ++ ++ + E + ++ ++ + A+
Sbjct: 1050 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT-- 1107
Query: 2182 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---------DLCQHQD 2232
P+ + T +++L + E QQ D L + G L ++ + ++
Sbjct: 1108 LPELEATK--ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1165
Query: 2233 RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSA 2292
RV L + + + R+++ QL +R+ WL++ + A
Sbjct: 1166 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1225
Query: 2293 --KELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME-----ITAPDSQGKTGSI 2345
+ + +Q+ ++LL++ G VEE N I + +T S
Sbjct: 1226 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1285
Query: 2346 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2405
GS + DL +++ + +Y K R E + + + +
Sbjct: 1286 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1345
Query: 2406 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2465
E + ++ K+ L A + K + + + E+ + Q+ K ++
Sbjct: 1346 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1405
Query: 2466 GLLVTYPNSQEAENWKKIQE----------------------------------ELNSRW 2491
L S EAE K ++ EL +
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1465
Query: 2492 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 2551
RA E A++RQ +E A L ESQ R E EL V A +
Sbjct: 1466 ARAEEAE-AQKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQA 1523
Query: 2552 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ--VQKELQSINQKWVELTDKL 2609
+ L+ EA R+ + E A+ + V+L T+Q + ELQS + E T +L
Sbjct: 1524 LEELRLQAEEAERRLRQAEVERARQV-----QVALETAQRSAEAELQSKRASFAEKTAQL 1578
Query: 2610 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRS 2669
RS Q + V L++ +E+ RA Q + ++ + E + QL+ +R
Sbjct: 1579 E-RSLQEEHVAVAQ------LREEAER-RAQQQAEAERAREEAERELERWQLKANEALRL 1630
Query: 2670 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK-RLETVALPLQGLEDLAADRINRLQA 2728
L+ EV + ++L + E+ ++ ++ + E A+ + L + ++ +L
Sbjct: 1631 RLQA--EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1688
Query: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQL----QENEEFQKSLNQH 2784
A Q+ + +R + +Q +Q + + +L RLQ + Q+ +E + L +
Sbjct: 1689 GTAQ-QRLAAEQELIRLRAETEQGEQQRQL-LEEELARLQREAAAATQKRQELEAELAKV 1746
Query: 2785 SGSYEVIVA-----EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK-----KTADRQS 2834
EV++A E ES S + K+ L+ + + EE ++ + A RQ
Sbjct: 1747 RAEMEVLLASKARAEEESRSTSE---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1803
Query: 2835 RLKD---CMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVE 2891
+L + Q+A+ + E L E + K +E + L + E+ LR A +
Sbjct: 1804 QLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQ 1862
Query: 2892 KRRSLLEILNSAADI---LINSSEADEDGIRDEKAGINQNMDA---VTEELQAKTGSLEE 2945
+RR + ADI L +A + + +K + + V EE+ A S E+
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1922
Query: 2946 MTQRLREFQESFKNIEKKVEG---AKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
E + I E +K Q E+ A Q + + + A++ V ++L
Sbjct: 1923 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1982
Query: 3003 QVDYLRNFTQGLVEDA---PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG- 3058
+ + R L E +A +L +AE L++ Q + E K
Sbjct: 1983 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2042
Query: 3059 -IGQFHCRVREMFSQLADLDDELDGMGAIGR-------------DTDSLQS--QIEDVRL 3102
+ Q +++ Q + D+L G R + ++ QS Q+E+
Sbjct: 2043 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2102
Query: 3103 FLNKIH------------VLKLDIEASEAECRHMLEEEGTL-DLLGLKRELEALNKQCGK 3149
KL EA + R E+ L E+E +K+ +
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-HKKFAE 2161
Query: 3150 LTERGKARQEQLELTLGRVE----DFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
T R KA+ EQ ELT R++ D + L AE EA + E E+ + +
Sbjct: 2162 QTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2220
Query: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265
+ Q E++ L+ +++ N + LI KD + L+ + E++ K+V
Sbjct: 2221 V------QMEELSKLKARIEAEN---RALILR-DKDNTQRFLQEEAEKM--------KQV 2262
Query: 3266 AQRIAQLQEALLHCGKFQD-ALEPLLSWLADTEELIANQKPPSAEYKVVKAQ---IQEQK 3321
A+ A+L A + + A E L A E+++ + E +KA+ +Q+QK
Sbjct: 2263 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2322
Query: 3322 LL-----QRLLDDRKATVDML--QAEGGRIAQSAELADREKITGQLESLESRWTELLSKA 3374
L +RL +D++ L + +G + AE + +++ + E L+ R E+ S+A
Sbjct: 2323 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRA 2381
Query: 3375 AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKA-- 3431
AR + ED A++F + AE I + L TE LA E V QT +IQ+Q H A
Sbjct: 2382 QARAE--ED----AQRFRKQAEEIGEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAER 2433
Query: 3432 LEE---DIENHATDVHQAVKIGQ------------SLSSLTSPAEQGVLSEKIDSLQARY 3476
L E ++E + Q K+ Q L T +Q LSEK DSL R
Sbjct: 2434 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-DSLLQRE 2492
Query: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEV------------------------------- 3505
I+ + L ++ A+ E++
Sbjct: 2493 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2552
Query: 3506 ----EVLNWLAEVEDKLSSVFVKDFKQ-----DVLHRQHADHLALNEEIVNRKKNVDQAI 3556
E L L + + + ++ ++ +L QH LA +EE+ + + +
Sbjct: 2553 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2612
Query: 3557 KNGQALLKQTTGEEVLLIQEKLDGIK-----TRYADITVTSSKALRTLEQ 3601
NG+ L E + DG++ R + + S++ L+ L Q
Sbjct: 2613 PNGRDALDGPAAEAE--PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2660
Score = 100 bits (249), Expect = 4e-20
Identities = 318/1624 (19%), Positives = 619/1624 (38%), Gaps = 261/1624 (16%)
Query: 3221 QMKLQ-QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC 3279
Q K Q +V GLG+G+ + + + V L E + TL ++ + +L++
Sbjct: 1012 QQKAQAEVEGLGKGVARLSAEAEKVLALP----EPSPAAPTLRSELELTLGKLEQVRSLS 1067
Query: 3280 GKFQDALEPLLSWLADT---EELIANQKPPSAEYKVVKAQIQEQ-------KLLQRLLDD 3329
+ + L+ + + T EE++ + E + V A + E K L+ +
Sbjct: 1068 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1127
Query: 3330 RKATVDMLQAE-------GGRIAQSAELAD------REKITGQLESLESRWTELLSKAAA 3376
++ T D L+ E G R+ Q D RE++ LE RW +L++
Sbjct: 1128 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE----RWQAVLAQTDV 1183
Query: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKALEED 3435
RQ++LE + + + E+A+P+ +L ++ + + + +++Q+ + +AL E+
Sbjct: 1184 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1243
Query: 3436 IENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495
IE H V + + A+Q + + K LQ + Q A + S
Sbjct: 1244 IERHGEKVEECQRF----------AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1293
Query: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD-Q 3554
+ ++ V++ +E+ L+S ++K + + + + LA + R++ + +
Sbjct: 1294 GSESVIQEYVDLRTHYSEL-TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1352
Query: 3555 AIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 3614
A Q L + + + + ++ R + V +A +Q + +S E
Sbjct: 1353 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK------RSIQE 1406
Query: 3615 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLD-TVNEVSRALLE 3673
EL + E E+ Q+ E + + +++E+ RL L+ T + A E
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAE------RSRLRIEEEIRVVRLQLEATERQRGGAEGE 1460
Query: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----QAADAELAWV 3729
L RAR +A Q + + + ++ QR +Q E AE
Sbjct: 1461 LQALRAR------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1514
Query: 3730 AETKRKLMALGPIRL---EQDQTTAQLQVQKAFSIDI---IRHKDSMDELFSHRSEIFGT 3783
E +R L AL +RL E ++ Q +V++A + + + + EL S R+
Sbjct: 1515 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF--- 1571
Query: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW-IEETR 3842
+KT E+ SL +++ A++ L E R ++ E EL W ++
Sbjct: 1572 ---AEKTAQLER--SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1626
Query: 3843 ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902
AL +L + + ++ Q E +Q E+ E + + +E + E+ E+
Sbjct: 1627 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------GKAEEQAVRQRELAEQ 1678
Query: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962
+ +K Q+ E Q+ LA ++ + + TE ++ +LE E L+ R+
Sbjct: 1679 ELEKQR----QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE--EELA---RLQREA 1729
Query: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4022
A K +E ++ E+E L S K R EE RS + + +
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLAS----KARAEE-ESRSTSEKSKQRLEAEAGRFRE 1784
Query: 4023 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4082
+ ++A AEE + + +LAE+ A + + + L + G + + +
Sbjct: 1785 LAEEAARLRALAEEAKRQ----RQLAEE-----DAARQRAEAERVLAEKLAAIG-EATRL 1834
Query: 4083 KQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT 4142
K + E A KE E E +R L D F E+ + D + L K
Sbjct: 1835 KTEAEIALKEKE------AENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKA 1887
Query: 4143 WKERLEK----LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP-PVGTDLNTVKDQLNE 4197
LE+ +ED ++ Q ++ + A+ + + +G + +D L
Sbjct: 1888 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1947
Query: 4198 MKEFKVEVYQQQ---IEMEKLNHQGELMLKK--ATDETDRDIIREPLTELKHLWENLGE- 4251
++ ++E +Q+ E E+ + E ++K A +E + L E++ L + E
Sbjct: 1948 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007
Query: 4252 -KIAHRQHKLEGALLALGQ-----------------FQHALEELMSWLTHTEELLDAQRP 4293
++ R + L L Q Q +EL L + +LD R
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2067
Query: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN----ELLESSAGDDASSLRSRLE 4349
E E A+ + + QA E E L+ SA + A +
Sbjct: 2068 --------EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2119
Query: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE--------------DFLLELTRMES 4395
A + + Q+ R Q Q+ L+Q Q +E+E ELT +
Sbjct: 2120 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2179
Query: 4396 QLSASKPTGGL------------PETAREQLDTHMELY---------SQLKAKEETYNQL 4434
QL + L E AR++ EL+ S+LKA+ E N+
Sbjct: 2180 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2239
Query: 4435 L---DKGRLMLLSRDDSGSGSKTEQSVALLE------------------QKWHVVSSKME 4473
L DK ++++ + + A L Q+ + ++
Sbjct: 2240 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2299
Query: 4474 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI-----EEHK 4528
E+ ++EA L E + L +Q +A + L Q+ EE +
Sbjct: 2300 EKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2348
Query: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588
F + A R + +E+ +LK + + Q+R E+ QR ++ +
Sbjct: 2349 GFQRTLEAERQRQLEMSAEAERLKLRVAE---------MSRAQARAEEDAQRFRKQAEEI 2399
Query: 4589 DDARKRAKQFHEAWKKLIDWLE--------DAESHLDSELEISNDPDKIKLQ---LSKHK 4637
+ R + + L+ LE DAE ++ E+ + +K++ + L
Sbjct: 2400 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2459
Query: 4638 EFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDS-QKLDNFLGEVRDKWDTVCGKSVERQH 4696
E +T+ +Q + +T +AL++ L +DS + + F+ + + K + + V +
Sbjct: 2460 EEMQTVQQEQLLQET-----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2514
Query: 4697 KLEE 4700
+L E
Sbjct: 2515 QLRE 2518
Score = 67.0 bits (162), Expect = 5e-10
Identities = 235/1255 (18%), Positives = 480/1255 (38%), Gaps = 105/1255 (8%)
Query: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 3922
EE RQ S+ + H L+ PE+ M E +Y + Y Q+ + + Q A
Sbjct: 906 EEQRQALHSL---ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGA 962
Query: 3923 LALDEAVSQSTQITEFHDKIEPMLETLENLS-SRLRMPPLIPAEVDKIREC---ISDNKS 3978
E I+E D I LE E + RLR +P + + REC I++ +
Sbjct: 963 ---QEESRCQRCISELKD-IRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQK 1014
Query: 3979 ATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038
A E+E L L E+++ + + AA ++ +L+ + E +++
Sbjct: 1015 AQAEVEGLGKGVARLSAEAEKVLALPEPSP---AAPTLRSELELTLGKLEQVRS-LSAIY 1070
Query: 4039 IKFLDVLELAEKFWYDMAALLTT----IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094
++ L + L + +L +K+ Q + L + +K+ AE +
Sbjct: 1071 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1130
Query: 4095 ETDGLHEELEFIRILGADLIFACGE--TEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152
D L +EL + +G L GE E R+ + ++ W+ + R +LE
Sbjct: 1131 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190
Query: 4153 AMQAAVQYQDTLQAMFDWLDNT---VIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQ-- 4207
+ Y+++ + WL + ++ MP D V++QL + + E+ +
Sbjct: 1191 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL--ADSQAVREQLRQEQALLEEIERHG 1248
Query: 4208 ------QQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN---LGEKIAHRQH 4258
Q+ + +N + L+ T + + + P + K + + E + R H
Sbjct: 1249 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1308
Query: 4259 KLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--------LAKHHV 4310
E L Q+ + E + + E L + QR + ++ EVE LA+ H
Sbjct: 1309 YSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHA 1366
Query: 4311 LKNDVLAHQATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4368
+ A + E + E++ E +A D RS E + Q +S + + + +Q
Sbjct: 1367 -QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1425
Query: 4369 LQSTLQQAQGFHSEIEDFLLELTRMESQLSAS----KPTGGLPETAREQLDTHMELYSQL 4424
++ + EI L+L E Q + + E A Q E +L
Sbjct: 1426 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1485
Query: 4425 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA-L 4483
+ + + +Q + + L SR + + + E+ AL Q + + EE + +L +A +
Sbjct: 1486 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEV 1543
Query: 4484 NLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA---NEVNAHRDQ 4540
A + Q +L E AE AS S EEH A E Q
Sbjct: 1544 ERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1602
Query: 4541 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI---ERGRSLDDARKRAKQ 4597
E ++ + + ++ + + L + +Q+ E Q+S+ E + ++A + A++
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARR 1661
Query: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH--KEFQKTLGGKQPVYDTTIR 4655
+A ++ + E AE L+ + +++ + +L + + +T G+Q
Sbjct: 1662 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1721
Query: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
R +E + Q+L+ L +VR + + + + EE+ S + L+A
Sbjct: 1722 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAE 1778
Query: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775
++ + A + + Q++L + Q R E
Sbjct: 1779 AGRFRELAEEAAR-----------LRALAEEAKRQRQLAEEDAARQ------RAEAERVL 1821
Query: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF--RDTVHMLLEWLSEAEQT 4833
+ G+ L T + K ++ RL + L + E F R + ++ E+
Sbjct: 1822 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1880
Query: 4834 L-RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKH 4892
L + R A + E + L++ ++VEE+ + + ++ A + +
Sbjct: 1881 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1940
Query: 4893 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIP 4952
+R++ + L A+Q Q E A + + L A + A R ++
Sbjct: 1941 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA------RQRKAAL 1994
Query: 4953 QNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI---EPTHAPFIEKSRSGGRKS 5009
+ ++R+KA + E + E ++ ++ + +K + E HA +++ +++
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2054
Query: 5010 LSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064
L Q + ++EA + Q A + +R++ +A +RL++ E
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAE 2108
Score = 39.7 bits (91), Expect = 0.082
Identities = 26/54 (48%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 5350 SASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRR 5403
S S GS AGSR GSR SR GS FD T S S T SS+ G RR
Sbjct: 4465 SVSGSGSTAGSRTGSRTGSRAGSRRGSFD--ATGSGFSMTFSSSSYSSSGYGRR 4516
Score = 34.3 bits (77), Expect = 3.5
Identities = 49/247 (19%), Positives = 98/247 (39%), Gaps = 25/247 (10%)
Query: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635
+V +S++R L+D+ R Q L+ W+E+ + +D E D ++ QL
Sbjct: 491 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 543
Query: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEK-TLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
H+ G Q + + + RA ++ L P + LG + ++ + S R
Sbjct: 544 HR------GLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 597
Query: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLM---DAHKVFQK 4751
LE F+ A + WL + E E++ D N+ +++ +
Sbjct: 598 LRSLESL----HSFVAAATKELMWLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMR 649
Query: 4752 ELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALK 4811
EL + ++ L+ +G L+ V+ L T+W + +L ++ L++
Sbjct: 650 ELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAA 709
Query: 4812 QAEVFRD 4818
+ F D
Sbjct: 710 YFQFFSD 716
>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
Length = 1369
Score = 1142 bits (2954), Expect = 0.0
Identities = 586/1230 (47%), Positives = 835/1230 (67%), Gaps = 34/1230 (2%)
Query: 74 DERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRF 133
DERDRVQKKT TKWVNKHL+K ++HI+DLYEDLRDGHNLISLLEVLSG LPREKGRMRF
Sbjct: 171 DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230
Query: 134 HRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGD 193
H+LQNVQIALD+L+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI +SG+S D
Sbjct: 231 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290
Query: 194 MSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRE 253
M+AKEKLLLW+Q++ GY G++C NF+S W DG++FNA+IHR++P L+DM +V Q+N E
Sbjct: 291 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350
Query: 254 NLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEV 312
NL+QAF VAER LGVTRLLD EDVDVP PDEKS+ITYVSS+YDA P+VP+ +G+ A E+
Sbjct: 351 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
Query: 313 DSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKG 372
RWQEY+ V L+ W++ HT ++ FP + E++ L++Q++ FKE E+ AKE +K
Sbjct: 411 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
Query: 373 RIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQI 432
R + +Y+ LE ++ G++K+P GYHP DVE+EWGKL + +LEREK LR ERLE L +I
Sbjct: 471 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
Query: 433 ANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQ 492
K+Q A CEE+L A LQ+D L +G+ Q +V + + + +IR L D+Q
Sbjct: 531 VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
Query: 493 ILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEP 552
L+D + Q E++ RV RL + LV +R E + G A P
Sbjct: 591 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG------------------VAAP 632
Query: 553 LTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDL 612
T+ + S R+P EL ++ LR++ +LL+WVEE Q +++ AEWG DL
Sbjct: 633 ATQVAQVTLQSVQRRP----EL-------EDSTLRYLQDLLAWVEENQHRVDGAEWGVDL 681
Query: 613 PSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETS 672
PSVE QL + + +H S+EE + ++ AR EG++S +Y + LG+L+ QY KL +S
Sbjct: 682 PSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSS 741
Query: 673 SFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEK 732
R+R L+SLH FV+ AT EL+WLNEKEEEE+ +DWSD N+N++AK+ +S L ELE K
Sbjct: 742 KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 801
Query: 733 QDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFF 792
+ + LQ+ + L E+HPA+ TVE++ AA+Q+Q WM QLC C+E H+KEN AYFQFF
Sbjct: 802 EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFF 861
Query: 793 SDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRS 852
SD RE E L+ LQ++++RK SCD + +++RLEDLLQD+ DEKEQL + K ++ L R+
Sbjct: 862 SDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 921
Query: 853 KTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNE 912
K +VQLKPR P H ++ + + AVCDY+Q+E+T+ K DEC L +Q + WKV+S +G+E
Sbjct: 922 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 981
Query: 913 AMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQT 972
A VPSVCFL+PPPN++ E +R+E +Q ++ LWHQLHV+ KSL++W LR+D+ L+++
Sbjct: 982 AAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 1041
Query: 973 WNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHL 1032
W+L R+ P E Q + +L+ HY+ FL+DS+D+ F DRL E E +C +Q L
Sbjct: 1042 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQL 1101
Query: 1033 MKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIA 1092
++S+E +EE+ + ISELK+IRL+LE E R V R++ D++ ++ A RIA
Sbjct: 1102 LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR----LPLDKEPARECAQRIA 1157
Query: 1093 EQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVY 1152
EQ+ Q +++ L + +S + + L S + PTLRSEL L + K++ V LS +Y
Sbjct: 1158 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1217
Query: 1153 LNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNS 1212
L KLKT+ +++R Q AE +++ +E +L + + V A L LEA ++L+ + + +
Sbjct: 1218 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1277
Query: 1213 VFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELES 1272
F L +E+ A+ V E++ + ER++++ER++E+ +QL ERW V+AQ ++RQ ELE
Sbjct: 1278 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1337
Query: 1273 IQEVLGDYRACHGTLIKWIEETTAQQEMMK 1302
+ L YR L W+++ +QE ++
Sbjct: 1338 LGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
Score = 55.5 bits (132), Expect = 1e-06
Identities = 170/934 (18%), Positives = 373/934 (39%), Gaps = 140/934 (14%)
Query: 3198 EVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINAR 3257
E+EI+ Q FK + + + + + + +G +Q+ V H ++ +
Sbjct: 446 EIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAG--QLKVPPGYHPLD-VEKE 502
Query: 3258 WNTLNKKVAQRIAQLQEAL--------------LHCGKFQDALEPLLSWLADTEELIANQ 3303
W L+ + +R QL+ + G ++ L + L L+A
Sbjct: 503 WGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAG 562
Query: 3304 KPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADRE-KITGQLES 3362
K P +V + + +++ L +D + D GR Q ++ R ++ +L +
Sbjct: 563 KVPQRAGEVERDLDKADSMIRLLFNDVQTLKD------GRHPQGEQMYRRVYRLHERLVA 616
Query: 3363 LESRWT-ELLSKAAARQKQLEDILVLAKQFHETAEP-----ISDFLSVTEKKLANSEPV- 3415
+ + + L + AA Q+ + + + Q E + D L+ E+ +
Sbjct: 617 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAE 676
Query: 3416 -GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQA 3474
G ++ Q+ H+ L + IE + +A +S SPA +G + + L
Sbjct: 677 WGVDLPSVEAQLGSHRGLHQSIEEFQAKIERA----RSDEGQLSPATRGAYRDCLGRLDL 732
Query: 3475 RYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQ 3534
+Y+++ + KA L ++L + F + L WL E E++ D ++ ++
Sbjct: 733 QYAKLLNSS--KARL--RSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKK 788
Query: 3535 HADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSK 3594
+ + AL E+ ++K + + G LL++ ++ ++T+++ +
Sbjct: 789 ES-YSALMRELELKEKKIKELQNAGDRLLREDHPARPT-VESFQAALQTQWSWMLQLCCC 846
Query: 3595 ALRTLEQARQLATKFQSTYEELTGWLREVEEELA--TSGGQSPTGEQIPQFQQRQKELKK 3652
L++ +F S E G L++++E L S +S T ++ Q ++ K+
Sbjct: 847 IEAHLKE-NAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKE 905
Query: 3653 EVMEHRLVLDTVNEVSRALLELVP------WRAREGL------------------DKLVS 3688
++ E++ L + + ++A+++L P R R L +LV
Sbjct: 906 QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVG 965
Query: 3689 DANEQYKLVSDTIGQRV-------------DEIDAAIQRSQQYEQAADAELAWVAETKRK 3735
A + V + G E+ A+ R + QA + +
Sbjct: 966 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKS 1025
Query: 3736 LMALGPIRLEQDQTTAQLQVQKAFSIDIIR------HKDSMDEL------FSHRSEIFGT 3783
L+A +R + +Q+ +++S+ R + ++ L F S+ G
Sbjct: 1026 LLAWQSLRRD-------VQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 1078
Query: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE-RAQVLVNQFWETYEELSPWIEETR 3842
G E + + + + S Y+ + L + E+ A+ E R Q +++ + +L ETR
Sbjct: 1079 FGPEDRLMAEREYGSCSHHYQQL-LQSLEQGAQEESRCQRCISELKDIRLQLEAC--ETR 1135
Query: 3843 ALIAQLPSPAIDHEQLRQ----------QQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL 3892
+ +L P +D E R+ Q E+ L + +A +K+L + P+
Sbjct: 1136 T-VHRLRLP-LDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL-PEPSPA 1192
Query: 3893 NP---EEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 3949
P E E+ K ++ ++ A E+++ +L + + TQ E E L
Sbjct: 1193 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAE---------EVL 1238
Query: 3950 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALK--RRGEELIG---RS 4004
+L+ +PA + ++ + K + E QP+F+AL+ RG + +G +
Sbjct: 1239 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1298
Query: 4005 QGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038
+ ++D+ + ++++ Q++ W+ + A+ + R+
Sbjct: 1299 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1332
Score = 48.5 bits (114), Expect = 2e-04
Identities = 80/379 (21%), Positives = 144/379 (37%), Gaps = 58/379 (15%)
Query: 2192 QQIQELNLEMEDQQENLDTLEH-LVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE 2250
Q++QE +E Q + L TL H L ++ S L + VQ +R +T+K
Sbjct: 996 QEVQEAVTRLEAQHQALVTLWHQLHVDMKSL---LAWQSLRRDVQLIRSWSLATFRTLKP 1052
Query: 2251 REKDASSCQEQLDEFRKLVRTFQKWLKETE--GSIPPTETSMSAKELEKQIEHLKSLLDD 2308
+EQ L +Q +L++++ G P + M+ +E H + LL
Sbjct: 1053 --------EEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQS 1104
Query: 2309 WASKGTLVEEINCKG--TSLENLIMEITAPDSQGKTGSILP--------------SVGSS 2352
EE C+ + L+++ +++ A +++ LP +
Sbjct: 1105 LEQGAQ--EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKA 1162
Query: 2353 VGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVH-------- 2404
V G K + + + V E R E L+ L ++E+V
Sbjct: 1163 QAEVEGLG--KGVARLSAEAEKVLALPEPSPAAPTLRSE-LELTLGKLEQVRSLSAIYLE 1219
Query: 2405 --KEANSVLQWLESKEEVLKS-----MDAMSSPTKTETVKAQAESNKAFLAELEQNSPKI 2457
K + V++ + EEVL++ +A + P ++A S K A+ E P
Sbjct: 1220 KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF 1279
Query: 2458 QKVKEALAGLLVTYPNSQ--------EAENWKKIQEELNSRWERATEVTVARQRQLEESA 2509
+++ L G Q E E W++ +L RW+ T RQR+LE+
Sbjct: 1280 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLG 1339
Query: 2510 SHLACFQAAESQLRPWLME 2528
L ++ + L WL +
Sbjct: 1340 RQLRYYRESADPLGAWLQD 1358
Score = 43.5 bits (101), Expect = 0.006
Identities = 43/238 (18%), Positives = 95/238 (39%), Gaps = 21/238 (8%)
Query: 2635 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE 2694
E R QR++ Q + E + + + S + L A TL EL + +G+
Sbjct: 1147 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1206
Query: 2695 ----QYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750
+ L ++L+T++L ++G + A + + + L Q EL
Sbjct: 1207 LEQVRSLSAIYLEKLKTISLVIRGTQG-AEEVLRAHEEQLKEAQAVPATLPELEATKASL 1265
Query: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810
+ +A+ + L+ +L+ +E + L Q G +V E
Sbjct: 1266 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV----------------EVER 1309
Query: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELR 2868
+ ++ +L W+ + +T RQ L+ ++ + Y+ + L W++D + + +++
Sbjct: 1310 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
Score = 43.1 bits (100), Expect = 0.007
Identities = 68/321 (21%), Positives = 127/321 (39%), Gaps = 25/321 (7%)
Query: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 3922
EE RQ S+ + H L+ PE+ M E +Y + Y Q+ + + Q A
Sbjct: 1053 EEQRQALHSL---ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGA 1109
Query: 3923 LALDEAVSQSTQITEFHDKIEPMLETLENLS-SRLRMPPLIPAEVDKIREC---ISDNKS 3978
E I+E D I LE E + RLR +P + + REC I++ +
Sbjct: 1110 ---QEESRCQRCISELKD-IRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQK 1161
Query: 3979 ATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038
A E+E L L E+++ + + AA ++ +L+ + E +++
Sbjct: 1162 AQAEVEGLGKGVARLSAEAEKVLALPEPSP---AAPTLRSELELTLGKLEQVRS-LSAIY 1217
Query: 4039 IKFLDVLELAEKFWYDMAALLTT----IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094
++ L + L + +L +K+ Q + L + +K+ AE +
Sbjct: 1218 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1277
Query: 4095 ETDGLHEELEFIRILGADLIFACGE--TEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152
D L +EL + +G L GE E R+ + ++ W+ + R +LE
Sbjct: 1278 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1337
Query: 4153 AMQAAVQYQDTLQAMFDWLDN 4173
+ Y+++ + WL +
Sbjct: 1338 LGRQLRYYRESADPLGAWLQD 1358
Score = 37.0 bits (84), Expect = 0.53
Identities = 55/226 (24%), Positives = 104/226 (46%), Gaps = 25/226 (11%)
Query: 2796 ESLLLSVPPG-EEKRTLQNQLVELKN---HWEELSKKTADR------QSRLKDCMQKA-- 2843
+ LL S+ G +E+ Q + ELK+ E +T R + ++C Q+
Sbjct: 1099 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1158
Query: 2844 -QKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM-LNEVEKRRSL----L 2897
QK Q VE L + A+ ++ +P +L + L ++E+ RSL L
Sbjct: 1159 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYL 1218
Query: 2898 EILNSAADILINSSEADEDGIR--DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQE 2955
E L + + ++I ++ E+ +R +E+ Q + A EL+A SL+++ + Q
Sbjct: 1219 EKLKTIS-LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1277
Query: 2956 SFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALE 3001
+F + ++ GA+ E+ + L Q +++E R ++ V Q LE
Sbjct: 1278 TFDALRDELRGAQ---EVGERL-QQRHGERDVEVERWRERVAQLLE 1319
Score = 35.0 bits (79), Expect = 2.0
Identities = 47/212 (22%), Positives = 92/212 (43%), Gaps = 32/212 (15%)
Query: 3221 QMKLQ-QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC 3279
Q K Q +V GLG+G+ + + + V L E + TL ++ + +L++
Sbjct: 1159 QQKAQAEVEGLGKGVARLSAEAEKVLALP----EPSPAAPTLRSELELTLGKLEQVRSLS 1214
Query: 3280 GKFQDALEPLLSWLADT---EELIANQKPPSAEYKVVKAQIQEQ-------KLLQRLLDD 3329
+ + L+ + + T EE++ + E + V A + E K L+ +
Sbjct: 1215 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1274
Query: 3330 RKATVDMLQAE-------GGRIAQSAELAD------REKITGQLESLESRWTELLSKAAA 3376
++ T D L+ E G R+ Q D RE++ LE RW +L++
Sbjct: 1275 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE----RWQAVLAQTDV 1330
Query: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKK 3408
RQ++LE + + + E+A+P+ +L ++
Sbjct: 1331 RQRELEQLGRQLRYYRESADPLGAWLQDARRR 1362
Score = 34.7 bits (78), Expect = 2.7
Identities = 48/246 (19%), Positives = 97/246 (39%), Gaps = 23/246 (9%)
Query: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635
+V +S++R L+D+ R Q L+ W+E+ + +D E D ++ QL
Sbjct: 638 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 690
Query: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ 4695
H+ +++ + I R+ E L P + LG + ++ + S R
Sbjct: 691 HRGLHQSI----EEFQAKIERARS-DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARL 745
Query: 4696 HKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLM---DAHKVFQKE 4752
LE F+ A + WL + E E++ D N+ +++ +E
Sbjct: 746 RSLESL----HSFVAAATKELMWLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 797
Query: 4753 LGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQ 4812
L + ++ L+ +G L+ V+ L T+W + +L ++ L++
Sbjct: 798 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 857
Query: 4813 AEVFRD 4818
+ F D
Sbjct: 858 FQFFSD 863
Score = 34.7 bits (78), Expect = 2.7
Identities = 58/271 (21%), Positives = 108/271 (39%), Gaps = 35/271 (12%)
Query: 4367 QQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTG----GLPETAREQLDTHMELYS 4422
QQL +L+Q S + + EL + QL A + LP + +
Sbjct: 1099 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1158
Query: 4423 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQK--WHVVSSKMEERKSKLE 4480
Q KA+ E L KG L ++ E+ +AL E + S++E KLE
Sbjct: 1159 QQKAQAEVEG--LGKGVARL--------SAEAEKVLALPEPSPAAPTLRSELELTLGKLE 1208
Query: 4481 EALNLATEFQNSLQEF---INWLTLAEQSLNIASPP---SLILNTVLSQIEEHKVFANEV 4534
+ +L+ + L+ I AE+ L + + L ++E K ++
Sbjct: 1209 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1268
Query: 4535 NAH-----------RDQIIELDQTGNQLKFLSQKQDVVLIK--NLLVSVQSRWEKVVQRS 4581
A RD++ + G +L+ ++DV + + + + RW+ V+ ++
Sbjct: 1269 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1328
Query: 4582 IERGRSLDDARKRAKQFHEAWKKLIDWLEDA 4612
R R L+ ++ + + E+ L WL+DA
Sbjct: 1329 DVRQRELEQLGRQLRYYRESADPLGAWLQDA 1359
Score = 33.9 bits (76), Expect = 4.5
Identities = 26/105 (24%), Positives = 51/105 (48%), Gaps = 12/105 (11%)
Query: 1566 AERALAGHQGRTTQQD-----LSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN 1620
AE L H+ + + L L+ ++ LK L+ + + +F + ++ G E
Sbjct: 1234 AEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVG 1293
Query: 1621 QTKLSPR------ELTALREKLHQAKEQYEALQEETRVAQKELEE 1659
+ +L R E+ RE++ Q E+++A+ +T V Q+ELE+
Sbjct: 1294 E-RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1337
>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
Length = 3062
Score = 1111 bits (2874), Expect = 0.0
Identities = 567/1185 (47%), Positives = 825/1185 (69%), Gaps = 82/1185 (6%)
Query: 425 RLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLI 484
RLE+L QIAN++Q ++ CE+KL LA N LQ+D+ LESG Q E+++ YI ECE L+
Sbjct: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
Query: 485 RQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLEC--------------TNLYRKG 530
RQ +D+QIL D YYQ ++L RV +L+DE++ LR EC T L G
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
Query: 531 HFTSL-----ELVPPSTLT------TTHLKAEPLTKATHSSSTS---------------- 563
SL + + PS + T L + +T S TS
Sbjct: 176 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
Query: 564 ---------------------WFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMK 602
RKP+ ++ L+ + +E+E N++FV +LL+WV+EMQ++
Sbjct: 236 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
Query: 603 LERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLE 662
L+R EWG+DLPSVE LE +++H ++EE SS+KEA++ E +M+ +YAE L +LE
Sbjct: 296 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
Query: 663 TQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYF 722
+QY KL TS + RHL +LH FVSRAT ELIWLNEKEEEE+AYDWS+ N+NI+ K++Y
Sbjct: 356 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
Query: 723 SELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHV 782
+EL EL++K++ +S+Q+ AE L LENHPA+ T+EAY AA+Q+Q W+ QLC CVEQH+
Sbjct: 416 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
Query: 783 KENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSK 842
KENTAYF+FF+DA+E +LRNL+D+I+RKYSCD ++S+ +LEDL+Q+SM+EKE+L+Q K
Sbjct: 476 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
Query: 843 SSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTK 902
S++A+L+G++KTI+QLKPR+ D LK +I +KA+CDYRQIEITI K+DECVL +NS R K
Sbjct: 536 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
Query: 903 WKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNY 962
WKVISPTGNEAMVPSVCF +PPPNK+A+++A+R+EQ YQ V+ LWH+ H+N KS++SW+Y
Sbjct: 596 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
Query: 963 LRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEV 1022
L ++D ++ N+ +++ PGE Q++ NLQ+ +EDFL+DS++S +FS +D +LE+EV
Sbjct: 656 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
Query: 1023 EACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRD 1082
CK +Q L+KS E E++EE+V +YISE++NIRLRLE E R++++I+ + +RD
Sbjct: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIR----TPLERD 771
Query: 1083 AWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKM 1142
++ RI EQE +++L++L+ DL ++ KC+ F Q+ +SSSVPTLRSELN++++ M
Sbjct: 772 DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM 831
Query: 1143 DHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRH 1202
+ VY +S+ Y++KLKTV++++++ Q AE LVK YE KL +EE V+AD + +E STL+
Sbjct: 832 NQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 891
Query: 1203 WLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQ 1262
W S+V +K VF L++E+ KAK ++++M + ER+LD + ++EK QL ERW V Q
Sbjct: 892 WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 951
Query: 1263 LEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTAL 1322
++ R +LE I + L YR + L WI++ Q ++ Q E+S+ L+ QL+QQ L
Sbjct: 952 IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1011
Query: 1323 FAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAIT 1382
+EIE Q+K+D+CQK+++QYS VKDYELQ MTY+A V+SQQKSP KRRRM SS+D I
Sbjct: 1012 VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII 1071
Query: 1383 QEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLA 1442
QEFMDLRTRYTALVTL TQ++K+ D+L+RLEEEEK +EEEK+EHVEK KEL WVS ++
Sbjct: 1072 QEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS 1131
Query: 1443 RNTQGKATSSETKESTDIEKA----ILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHK 1498
+ + D EKA +Q++ SEE++TKKEQ+SEA++T Q+FLAKHG K
Sbjct: 1132 KTLK------------DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDK 1179
Query: 1499 LSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQK 1543
++++E+ ++ +Q+ L ++Y+ L S QLQ+ Q+ + E+K
Sbjct: 1180 MTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEK 1224
Score = 74.7 bits (182), Expect = 2e-12
Identities = 171/956 (17%), Positives = 380/956 (39%), Gaps = 157/956 (16%)
Query: 931 EMASRVEQSYQKVM--ALWHQLHVNT--------KSLISWNYLRKDLDLVQTWNLEKLRS 980
E R+E Y K++ + + H++T + + W +++ ++ W+
Sbjct: 349 EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 408
Query: 981 SAPGECH-QIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEE-----VEACKARFQ---- 1030
+ + H ++M+ L E+ + +A++L LE +EA +A Q
Sbjct: 409 ARKKDYHAELMRELDQKEENIKS------VQEIAEQLLLENHPARLTIEAYRAAMQTQWS 462
Query: 1031 ---HLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDN 1087
L + +E KE T + ++ K L + + ++ SS + +D
Sbjct: 463 WILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHK--LED- 519
Query: 1088 ALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYG 1147
+ E +E+L Q +S + + K + + P +S P
Sbjct: 520 --LVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCP------------------ 559
Query: 1148 LSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDV 1207
LKT + +++I D + EI + +++ + ++ A W + S
Sbjct: 560 --------LKT-SIPIKAICDYRQI----EITIYKDDECVLANNSHRAKWKVI----SPT 602
Query: 1208 KDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQE--RWHRVIAQLE- 1264
++ V SV K + +R+ + L + E ++ WH +I +++
Sbjct: 603 GNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDR 662
Query: 1265 IRQSELESIQEVL-GDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALF 1323
IR S + SI+ +L G+++ L E+ + + D L ++++ +
Sbjct: 663 IRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYY 722
Query: 1324 AEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQ 1383
E+ ++ + +Q + Y + V++ L+L + + Q ++P +R + S IT+
Sbjct: 723 QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITE 782
Query: 1384 EFM---DLRTRYTALVTLTTQHVKYISDA-----LRRLEEEEKVVEEEKQE-------HV 1428
+ +L L T+T + ++ S A + L E VV + + ++
Sbjct: 783 QEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI 842
Query: 1429 EKVKELLGWVSTLARNTQGKATSSETKEST--DIEKAILEQQVLSEELTTKKEQVSEAIK 1486
+K+K V+ + +NTQ + E+ + E I ++ + ++T K+ SE +
Sbjct: 843 DKLKT----VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDE 898
Query: 1487 TSQIFLAKHGHKLSEKEKKQISEQLNALNKA-------YHDLCDGSANQLQQLQSQLAHQ 1539
Q+F H + ++ K IS+++ K + + D + Q + Q+ ++
Sbjct: 899 KRQVF---HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
Query: 1540 TEQ-----KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKD 1594
K+L+ ++T H L+D V +R + +Q ++ + L + + + +
Sbjct: 956 LRDLEGIGKSLKYYRDTYHP-LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE 1014
Query: 1595 LQ------DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQY---EA 1645
++ D+ Q A ++ VKD E + + ++ + ++ + Q+ E
Sbjct: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
Query: 1646 LQEETR------VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSG 1699
+ TR + + ++ A S + E E+ +E E+ +K L WV+++ +
Sbjct: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKT- 1133
Query: 1700 GQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNF 1759
L E+ K K +E+ ++++
Sbjct: 1134 ------LKDAEKAGKPPFSK-------------------------QKISSEEISTKKEQL 1162
Query: 1760 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQD 1815
A Q+ Q FL +HG +T EE+ L++++ L+E Y+ ++S +L++ QT D
Sbjct: 1163 SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGD 1218
Score = 68.6 bits (166), Expect = 2e-10
Identities = 193/1020 (18%), Positives = 396/1020 (38%), Gaps = 147/1020 (14%)
Query: 3486 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 3545
K++LLDQ L+ + + ++LNW+ E++ +L + L E
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRT------------EWGSDLPSVESH 311
Query: 3546 VNRKKNVDQAIKNGQALLKQTTGEEV-------LLIQEKLDGIKTRYADITVTSSKALRT 3598
+ KNV +AI+ ++ LK+ E+ L EKL ++++YA + TS R
Sbjct: 312 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
Query: 3599 LEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR 3658
L+ ++ +T E + WL E EEE + S I + + EL +E+ +
Sbjct: 372 LDTLHNFVSR--ATNELI--WLNEKEEE-EVAYDWSERNTNIARKKDYHAELMRELDQKE 426
Query: 3659 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 3718
+ +V E++ LL L AR ++ + Q+ + +Q Q
Sbjct: 427 ENIKSVQEIAEQLL-LENHPARLTIEAYRAAMQTQWSWI--------------LQLCQCV 471
Query: 3719 EQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSI----DIIRHK-DSMDEL 3773
EQ A+ A +R +D + ++ SI D+++ + +EL
Sbjct: 472 EQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 531
Query: 3774 FSHRSEIFGTCGEEQKTVLQEK---TESLIQQYEAISLLNSERYARL-----ERAQVLVN 3825
++S I G+ KT++Q K ++ ++ I + R + + + N
Sbjct: 532 LQYKSTIANLMGKA-KTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANN 590
Query: 3826 QFWETYEELSPWIEETR--ALIAQLPSP---AID-HEQLRQQQEEMRQL-------RESI 3872
++ +SP E ++ +P P A+D ++ QQ + + L +S+
Sbjct: 591 SHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSV 650
Query: 3873 AEHKPHIDKLLKIGPQ----LKELNPEEGEMVEEKYQKAENMY---------------AQ 3913
I+++ +I +K + P E + V Q + Q
Sbjct: 651 VSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
Query: 3914 IKEEVR------QRALALDEAVSQSTQITEFH-DKIEPMLETLENLSSRLRMPPLIPAEV 3966
+++EV Q L E Q + + ++ + LEN RL P E
Sbjct: 711 LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLER 770
Query: 3967 DKIREC---ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQM 4023
D + E I++ + ELE+L+ + + EE ++ + + ++ +L+ +
Sbjct: 771 DDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVV 827
Query: 4024 VFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIK 4083
+ + + + ++D L+ + A +K + + + E+ D + I+
Sbjct: 828 LQNMNQVYSMSST----YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIE 883
Query: 4084 QQVEAAETIKEETD-------GLHEELEFIRILGADLIFACGETEKPEV--RKSIDEMNN 4134
+ + + E D L +EL+ + + ++ E + ++ D++
Sbjct: 884 NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE 943
Query: 4135 AWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL---DNTVIKLCTMPPVGTDLNTV 4191
W+N++ RL LE ++ Y+DT + DW+ + T K+ P + T+
Sbjct: 944 RWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS--KTL 1001
Query: 4192 KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE 4251
QLN+ K E+ +Q +M++ E T +D + +T + + ++ +
Sbjct: 1002 ATQLNQQKMLVSEIEMKQSKMDECQKYAE-----QYSATVKDYELQTMT-YRAMVDSQQK 1055
Query: 4252 KIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELL----DAQRPISGDPKVIEVELAK 4307
R+ A L + +F + +T + + D+ + + + K +E E K
Sbjct: 1056 SPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEE-KK 1114
Query: 4308 HHVLKNDVLAH-----QATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQ 4360
HV K L T++ KAG + + ++ S+ + +L Q + L
Sbjct: 1115 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLA 1174
Query: 4361 K-----TEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD 4415
K T+E +L+ ++ Q E + L + QL S+ +G + E+LD
Sbjct: 1175 KHGDKMTDEERNELEKQVKTLQ------ESYNLLFSESLKQLQESQTSGDV--KVEEKLD 1226
Score = 65.5 bits (158), Expect = 1e-09
Identities = 191/1028 (18%), Positives = 389/1028 (37%), Gaps = 155/1028 (15%)
Query: 1527 NQLQQLQSQLAHQTEQKTLQKQQNTCHQQL-----EDLCSWVGQAERALAGHQGRTTQQD 1581
N LQ L+ + K+ QN +++ +DL +WV + + L RT
Sbjct: 248 NSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL----DRTEWG- 302
Query: 1582 LSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTA-----LREKL 1636
SDL ++ ++N + +++ E ++E K+S ++TA EKL
Sbjct: 303 --------SDLPSVESHLENHK-NVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAEKL 351
Query: 1637 HQAKEQYEALQEETRVAQKELE---EAVTSALQQ-----ETEKSKAAKELAENKKKIDAL 1688
H+ + QY L +R ++ L+ V+ A + E E+ + A + +E I
Sbjct: 352 HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARK 411
Query: 1689 LDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG--ALDTTDGYMGVNQAPEKLDKQ-CEMM 1745
D+ + Q N+ +++++ L + A T + Y Q Q C+ +
Sbjct: 412 KDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCV 471
Query: 1746 KARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA 1805
+ +E + + F N E L+ ++ +YS + S
Sbjct: 472 EQHIKENTAYFEFF----------------NDAKEATDYLRNLKDAIQRKYSCDRSSSIH 515
Query: 1806 ELKQ-VQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSED 1864
+L+ VQ +E ++ LQ + + +++ ++ + P +K + +
Sbjct: 516 KLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQI 575
Query: 1865 VI-------------SHKGDLRFVTISGQKVLDMENSF---KEGKEPSEIGNLVKDKLKD 1908
I SH+ + ++ +G + + F KE ++ N ++ + ++
Sbjct: 576 EITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQN 635
Query: 1909 ATERYTALHSKCTRLGSHLNM-LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDP 1967
T H SH+NM + +H N D ++A + A+++ +L P
Sbjct: 636 V---LTLWHE------SHINMKSVVSWHYLINEIDRIRA---SNVASIKTML-------P 676
Query: 1968 GVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQ 2027
G Q+ L+ + E+ E + DI ++E E ++ QE S
Sbjct: 677 GEHQQVLSNLQSRFEDFLEDSQESQVFS--GSDITQLEKEVNVCKQYYQELLKS------ 728
Query: 2028 SLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALAT 2087
AER Q +SV S +++I +N E + + + + + ++ L
Sbjct: 729 ------AEREE-------QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
Query: 2088 NM-------KLKQDIARQKSSL-EATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLC 2139
++ KLK+++ R K L T + F + A S++ L+ +L V Q Q+
Sbjct: 776 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
Query: 2140 LQQQ---EKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQE 2196
+K ++ +L + E L + + + ++A N +I + +++
Sbjct: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN----NIENLISTLKQ 891
Query: 2197 LNLEMEDQQENLDTLEHLVTELSSCGFA---------LDLCQHQDRVQNLRKDFTELQKT 2247
E++++++ LE + + + LD H+++ L + + +
Sbjct: 892 WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 951
Query: 2248 VKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLD 2307
+ R +D + L +R W+++ E + K E Q E+ K+L
Sbjct: 952 IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVE--------TTQRKIQENQPENSKTLAT 1003
Query: 2308 DWASKGTLVEEINCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGS-VNGYHT 2361
+ LV EI K + ++ T D + +T + V S S V
Sbjct: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRM 1063
Query: 2362 CKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL 2421
I + D+ +Y L ++ + + L R+EE K E KE V
Sbjct: 1064 QSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE-----EKKEHVE 1118
Query: 2422 KSMDAMSSPTK-TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENW 2480
K+ + + ++T+K ++ K ++ + +S +I KE L+ L T
Sbjct: 1119 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD 1178
Query: 2481 KKIQEELN 2488
K EE N
Sbjct: 1179 KMTDEERN 1186
Score = 65.1 bits (157), Expect = 2e-09
Identities = 196/1101 (17%), Positives = 410/1101 (37%), Gaps = 213/1101 (19%)
Query: 2036 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2095
+SSLL + + + + + ++ LL + E++ L+ + S D+
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGS------------------DL 305
Query: 2096 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEK----ESSLKK 2151
+S LE + V R +E +S+ + + K++E+ Q L L EK ES K
Sbjct: 306 PSVESHLE-NHKNVHRAIEEFESS---LKEAKISEI-QMTAPLKLTYAEKLHRLESQYAK 360
Query: 2152 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL------------ 2199
LL + E L F+ + L N+ +++ + + N+
Sbjct: 361 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420
Query: 2200 EMEDQQENLDTLEHLVTEL-------------------SSCGFALDLCQHQDR------- 2233
E++ ++EN+ +++ + +L + + L LCQ ++
Sbjct: 421 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480
Query: 2234 ---VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM 2290
N K+ T+ + +K+ + SC ++ KL Q+ ++E E + T
Sbjct: 481 YFEFFNDAKEATDYLRNLKDAIQRKYSC-DRSSSIHKLEDLVQESMEEKEELLQYKSTIA 539
Query: 2291 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME----ITAPDSQGKTGSIL 2346
+ K I LK D K ++ + C +E I + + A +S ++
Sbjct: 540 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVI 599
Query: 2347 PSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKE 2406
G+ + T + D+++ ++ Q +L E H
Sbjct: 600 SPTGNEAMVPSVCFTVPPPNKEAVDLAN-------------RIEQQYQNVLTLWHESHIN 646
Query: 2407 ANSVLQW--LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL 2464
SV+ W L ++ + +++ + S T Q SN L ++ + + +
Sbjct: 647 MKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSN---LQSRFEDFLEDSQESQVF 703
Query: 2465 AGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRP 2524
+G +T + + QE L S A + + EES +L + +LR
Sbjct: 704 SGSDITQLEKEVNVCKQYYQELLKS----------AEREEQEESVYNLYISEVRNIRLRL 753
Query: 2525 WLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDV 2584
E L+ + PL D + F + E E +++ E+L + G +T +
Sbjct: 754 ENCEDRLIRQIRTPLERD------DLHESVFRITEQEKLKKELERLKDDL-GTITNKCEE 806
Query: 2585 SLSTSQVQKELQSINQKWVELTDKLNS----RSSQIDQA-----IVKSTQYQELL----- 2630
S + + ++ + + +N S+ ID+ ++K+TQ E L
Sbjct: 807 FFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYE 866
Query: 2631 QDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV 2690
L E+ + + ++++ IST +KQ E E R L+ E+++A+ + DE+
Sbjct: 867 TKLCEEEAVIADKNNIENLIST----LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
Query: 2691 LIGEQYLK-DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD 2749
E+ L D K++ + + Q + +R+ L+ S + ++ + L W+
Sbjct: 923 TYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQ- 981
Query: 2750 KQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKR 2809
++E Q ++QEN+ E +
Sbjct: 982 -------------QVETTQRKIQENQP-----------------------------ENSK 999
Query: 2810 TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV 2869
TL QL + K E+ K QS++ +C + A++Y V+D
Sbjct: 1000 TLATQLNQQKMLVSEIEMK----QSKMDECQKYAEQYSATVKD----------------- 1038
Query: 2870 TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNM 2929
E + +AM++ +K + S+AD++I + Q +
Sbjct: 1039 ------YELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI 1092
Query: 2930 DAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL-- 2987
+ L+ + + + +E E K ++K V L+ + G S + +
Sbjct: 1093 KFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS 1152
Query: 2988 EKLRAQQEVL-QALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF-------- 3038
E++ ++E L +AL+ +L + ++ + ++L Q + Q+ +
Sbjct: 1153 EEISTKKEQLSEALQTIQLFLAKHGDKMTDE-----ERNELEKQVKTLQESYNLLFSESL 1207
Query: 3039 LEVKQRVNSGCVMMENKLEGI 3059
++++ SG V +E KL+ +
Sbjct: 1208 KQLQESQTSGDVKVEEKLDKV 1228
Score = 62.8 bits (151), Expect = 9e-09
Identities = 198/1074 (18%), Positives = 398/1074 (37%), Gaps = 197/1074 (18%)
Query: 4164 LQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFK--VEVYQQQIEMEKLNHQGEL 4221
+Q + +W+D ++L G+DL +V+ L K +E ++ ++ K++
Sbjct: 282 VQDLLNWVDEMQVQL-DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 340
Query: 4222 MLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWL 4281
K T E H E+ K+ + E L L F + WL
Sbjct: 341 APLKLT-----------YAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWL 389
Query: 4282 THTEELLDAQRPISGDPKVIEVELAK----HHVLKNDVLAHQATVETVNKAGNELLESSA 4337
EE ++ D +A+ H L ++ + +++V + +LL +
Sbjct: 390 NEKEE-----EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH 444
Query: 4338 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHS--EIEDFLLELT---R 4392
++ + AM W +LQ + EQ ++ + F+ E D+L L +
Sbjct: 445 -PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 503
Query: 4393 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML-LSRDDSGSG 4451
+ S L + +E ++ EL + T L+ K + ++ L +S
Sbjct: 504 RKYSCDRSSSIHKLEDLVQESMEEKEELLQY----KSTIANLMGKAKTIIQLKPRNSDCP 559
Query: 4452 SKTEQSVALL-----------------------EQKWHVVSSKMEERKSKL--------- 4479
KT + + KW V+S E
Sbjct: 560 LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPN 619
Query: 4480 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 4539
+EA++LA + Q++ N LTL +S + + + NE++ R
Sbjct: 620 KEAVDLANRIE---QQYQNVLTLWHES-----------HINMKSVVSWHYLINEIDRIRA 665
Query: 4540 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER----GRSLDDARKRA 4595
+ +K + + ++ NL QSR+E ++ S E G + K
Sbjct: 666 SNVA------SIKTMLPGEHQQVLSNL----QSRFEDFLEDSQESQVFSGSDITQLEKEV 715
Query: 4596 ---KQFHEAWKKLIDWLEDAESHLDS--------ELEISNDPDKIKLQLSKHKEFQKTLG 4644
KQ+++ K + E ES + L + N D++ Q+ E
Sbjct: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLE------ 769
Query: 4645 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ--------- 4695
+ ++++ R + E+ L ++ ++L + LG + +K + ++
Sbjct: 770 -RDDLHESVFR----ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 824
Query: 4696 ----HKLEEALLFSGQFMDALQAL---------VDWLYKV-EPQLAEDQPVHGDLDLVMN 4741
+ + S ++D L+ + + L K+ E +L E++ V D + + N
Sbjct: 825 NVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIEN 884
Query: 4742 LMDAHKVFQKELGKRTGTVQVL-------KRSGRELIENSRD---DTTWVKGQLQELSTR 4791
L+ K ++ E+ ++ L K E+ + ++ D W K + +L R
Sbjct: 885 LISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVER 944
Query: 4792 WDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEALQSL 4850
W V ++ LE K + +RDT H L +W+ + E T R + P++++ L +
Sbjct: 945 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1004
Query: 4851 IDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQ 4910
++ K + ++E K+ ++ E A + T+ + RA +
Sbjct: 1005 LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTY-----RAMVDS------- 1052
Query: 4911 HQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME 4970
QQ+ + ++A+L+ + ++ T L+ + I D +K L E ++ E
Sbjct: 1053 -QQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1111
Query: 4971 EMTRKQPDVDRVTKTYK-RKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNP 5029
E K+ V++ + K NI T ++ + G+ PP SE +
Sbjct: 1112 E---KKEHVEKAKELQKWVSNISKT----LKDAEKAGK-------PPFSKQKISSEEIST 1157
Query: 5030 RINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVM 5089
+ QLS Q + L + K+ D EE E +K ++ + + +
Sbjct: 1158 KKEQLSEALQTIQLFLAKHGDKMTD-----EERNEL---------EKQVKTLQESYNLLF 1203
Query: 5090 -DFFRRIDKDQ-DGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDY 5141
+ +++ + Q G + +E +D ++A T E V +F G IDY
Sbjct: 1204 SESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGE---VLSVFQAVLRGLIDY 1254
Score = 60.1 bits (144), Expect = 6e-08
Identities = 192/1080 (17%), Positives = 404/1080 (37%), Gaps = 202/1080 (18%)
Query: 2612 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 2671
+SS +DQ + + + +QDL V + +L S P +V+ LE + +
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLP-SVESHLENHKNVHRAI 322
Query: 2672 EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRIN---RLQA 2728
E+ + +KEA+ I E + LK T A L LE A +N +
Sbjct: 323 EEFESSLKEAK---------ISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQER 370
Query: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 2788
L + F WL++K+ ++ S + + + + E + L+Q +
Sbjct: 371 HLDTLHNFVSRATNELIWLNEKEEEEVAY-DWSERNTNIARKKDYHAELMRELDQKEENI 429
Query: 2789 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEEL----------------------- 2825
+ + E LLL P + T++ ++ W +
Sbjct: 430 KSVQEIAEQLLLENHPA--RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFND 487
Query: 2826 SKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA 2885
+K+ D LKD +Q+ KY + +ED + E + E L
Sbjct: 488 AKEATDYLRNLKDAIQR--KYSCDRSSSIHKLEDLVQESME--------EKEELLQYKST 537
Query: 2886 MLNEVEKRRSLLEILNSAADILINSS----------EADEDGIRDEKAGINQNMDAVTEE 2935
+ N + K ++++++ +D + +S + + +D++ + N +
Sbjct: 538 IANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK 597
Query: 2936 LQAKTGSL--------------EEMTQRLREFQESFKNI----------EKKVEGAKHQL 2971
+ + TG+ +E ++ ++N+ K V + +
Sbjct: 598 VISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLI 657
Query: 2972 EIFDALGSQACSNKNLEKLRAQQEVLQALEPQV-DYLRNFTQGLVEDAPDGSDASQLLHQ 3030
D + + ++ Q+VL L+ + D+L + + V GSD +QL +
Sbjct: 658 NEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFS---GSDITQLEKE 714
Query: 3031 AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHC-RVREMFSQLADLDDELDGMGAIGRD 3089
V +Q + E+ + E + E + + VR + +L + +D L
Sbjct: 715 VNVCKQYYQELLKSAER-----EEQEESVYNLYISEVRNIRLRLENCEDRL--------- 760
Query: 3090 TDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGK 3149
I +R L + + E+ R +E+ +L LK +L + +C +
Sbjct: 761 -------IRQIRTPLERD-------DLHESVFRITEQEKLKKELERLKDDLGTITNKCEE 806
Query: 3150 LTERGKAR------QEQLELTLGRVEDFYR-------KLKGLNDATTAAEEAEALQWVVG 3196
+ A + +L + L + Y KLK +N + AEAL +
Sbjct: 807 FFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYE 866
Query: 3197 TEVEIINQQLAD---------------FKMFQKEQV-DPLQMKLQQVNGLGQGLIQS-AG 3239
T++ +AD ++ +K QV L+ +LQ+ + + ++
Sbjct: 867 TKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKE 926
Query: 3240 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLAD---T 3296
+D D + +++ RW ++ ++ R+ L+ ++D PL W+ T
Sbjct: 927 RDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETT 986
Query: 3297 EELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3356
+ I +P ++ K + Q+ +QK+L ++ +++ +D Q + SA + D E
Sbjct: 987 QRKIQENQPENS--KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQ 1042
Query: 3357 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3416
T ++ + K+ ++++++ L Q E + + + ++ + G
Sbjct: 1043 TMTYRAM----VDSQQKSPVKRRRMQSSADLIIQ--EFMDLRTRYTALVTLMTQYIKFAG 1096
Query: 3417 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQG----VLSEKIDSL 3472
+++++ K+LEE+ + H + K ++S AE+ +KI S
Sbjct: 1097 DSLKRLEEE---EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS- 1152
Query: 3473 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLH 3532
+ K L +AL +LF LA+ DK++ + ++ V
Sbjct: 1153 --------EEISTKKEQLSEALQTIQLF----------LAKHGDKMTDEERNELEKQVKT 1194
Query: 3533 RQHADHLALNEEI-----------VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 3581
Q + +L +E + V ++ +D+ I + QTTGE + + Q L G+
Sbjct: 1195 LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVI---AGTIDQTTGEVLSVFQAVLRGL 1251
Score = 48.1 bits (113), Expect = 2e-04
Identities = 178/991 (17%), Positives = 377/991 (38%), Gaps = 185/991 (18%)
Query: 1163 VRSIQDA--ELLVKGYEIKLSQEEVVLADLSALEAHWSTLRH-----------------W 1203
++S+Q+ +LL++ + +L+ E A +A++ WS + +
Sbjct: 429 IKSVQEIAEQLLLENHPARLTIE----AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEF 484
Query: 1204 LSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWH------ 1257
+D K+ L + I + K ++ S + +L E +EK LQ +
Sbjct: 485 FNDAKEATDYLRNLKDAIQR-KYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMG 543
Query: 1258 --RVIAQLEIRQSELESIQEV----LGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRV 1311
+ I QL+ R S+ + + DYR T+ K E A +
Sbjct: 544 KAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPT- 602
Query: 1312 LSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVE--------- 1362
+ + F N+ +D + QQY ++ + + K+ V
Sbjct: 603 -GNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661
Query: 1363 ---------SQQKSPGKRRRMLSSSDAITQEFM-DLRTRYTALVTLTTQHVKYISDALRR 1412
+ PG+ +++LS+ + ++F+ D + + TQ K ++ +
Sbjct: 662 RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY 721
Query: 1413 LEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETK---------ESTDIEKA 1463
+E K E E+QE E V L ++S + RN + + + E + E D+ ++
Sbjct: 722 YQELLKSAEREEQE--ESVYNL--YISEV-RNIRLRLENCEDRLIRQIRTPLERDDLHES 776
Query: 1464 IL---EQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKE-KKQISEQLNALNKAYH 1519
+ EQ+ L +EL K+ + + F ++ S + +++ L +N+ Y
Sbjct: 777 VFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY- 835
Query: 1520 DLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQ 1579
+ ++L+ + L + + L K T + E + + E ++ T +
Sbjct: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS-----TLK 890
Query: 1580 QDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQA 1639
Q S + + + L+D++Q A + D E F + L + +EK Q
Sbjct: 891 QWRSEVDEKRQVFHALEDELQK-----AKAISD-EMFKTYKERDL---DFDWHKEKADQL 941
Query: 1640 KEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSG 1699
E+++ + + ++LE K L + L DW+ V ++
Sbjct: 942 VERWQNVHVQIDNRLRDLEGI--------------GKSLKYYRDTYHPLDDWIQQVETTQ 987
Query: 1700 GQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNF 1759
++ N P + L + + ++ + K+D +C+ ++ + +++
Sbjct: 988 RKIQENQPENSKTLATQLNQQKMLVSE----IEMKQSKMD-ECQKYAEQYSATV---KDY 1039
Query: 1760 ILATQSAQAFLDQHGHNLTPEEQQMLQ-------QKLGELKEQYSTSLAQSEAELK---- 1808
L T + +A +D +P +++ +Q Q+ +L+ +Y+ + +K
Sbjct: 1040 ELQTMTYRAMVDSQ--QKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGD 1097
Query: 1809 -------QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSF 1861
+ ++L++E ++ ++ KE + W+ K L++ K G P +Q
Sbjct: 1098 SLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPP------FSKQKIS 1151
Query: 1862 SEDVISHKGDLR--------FVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERY 1913
SE++ + K L F+ G K+ D E N ++ ++K E Y
Sbjct: 1152 SEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER------------NELEKQVKTLQESY 1199
Query: 1914 TALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQ 1973
L S+ L Q + Q S D E ++K+++ T+ G E
Sbjct: 1200 NLLFSES----------LKQLQESQTSGD------VKVEEKLDKVIAGTIDQTTG---EV 1240
Query: 1974 LATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSH---FQSLS 2030
L+ + + L ++ + L+ + I G +P+ R + D+ SH + +
Sbjct: 1241 LSVFQAVLRGLIDYDTGIRLLETQ----LMISGLISPELRKCFDLKDA-KSHGLIDEQIL 1295
Query: 2031 YSLAERSSLLQKAIAQSQSVQESLESLLQSI 2061
L E S + A S + L++L QS+
Sbjct: 1296 CQLKELSKAKEIISAASPTTIPVLDALAQSM 1326
Score = 39.3 bits (90), Expect = 0.11
Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 12/191 (6%)
Query: 4802 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 4861
K S L+Q L + E+ V LL W+ E + L R D +++S ++ HK + +
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLD-RTEWGSDLPSVESHLENHKNVHRAI 322
Query: 4862 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 4921
EE + A + E+ + T + + +++ ++L ++ ++ L+T L
Sbjct: 323 EEFESSLKEA-KISEIQMTA---PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDT-LHN 377
Query: 4922 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDR 4981
V+ A L W+ E + D NI R K H M E+ +K+ ++
Sbjct: 378 FVSRA---TNELIWLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQKEENIKS 431
Query: 4982 VTKTYKRKNIE 4992
V + ++ +E
Sbjct: 432 VQEIAEQLLLE 442
Score = 37.7 bits (86), Expect = 0.31
Identities = 99/503 (19%), Positives = 204/503 (40%), Gaps = 69/503 (13%)
Query: 3417 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARY 3476
T+ K+++++ R K I N + S+ +L S E V+ + ++ + +
Sbjct: 781 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRS--ELNVVLQNMNQVYSMS 838
Query: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDK-----LSSVFVKDFKQDVL 3531
S D+ +L + L E ++ A + DK L S +K ++ +V
Sbjct: 839 STYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIST-LKQWRSEVD 897
Query: 3532 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLI---QEKLDGIKTRYADI 3588
++ H AL +E+ K D+ K T E L +EK D + R+ ++
Sbjct: 898 EKRQVFH-ALEDELQKAKAISDEMFK--------TYKERDLDFDWHKEKADQLVERWQNV 948
Query: 3589 TVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQ-QRQ 3647
V LR LE + ++ TY L W+++VE T +I + Q +
Sbjct: 949 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVE----------TTQRKIQENQPENS 998
Query: 3648 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 3707
K L ++ + ++++ + E+ ++ ++ A + S + Y+L + T VD
Sbjct: 999 KTLATQLNQQKMLVSEI-EMKQSKMDECQKYAEQ-----YSATVKDYELQTMTYRAMVDS 1052
Query: 3708 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHK 3767
+ + ++ + +AD + + + + AL T Q K F+ D ++
Sbjct: 1053 QQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL---------VTLMTQYIK-FAGDSLKRL 1102
Query: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAIS--LLNSERYAR--LERAQVL 3823
+ ++ EE+K EK + L + IS L ++E+ + + ++
Sbjct: 1103 EEEEKSL-----------EEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKIS 1151
Query: 3824 VNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLL 3883
+ E+LS ++ + +A+ D E+ + +++++ L+ES + + L
Sbjct: 1152 SEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER-NELEKQVKTLQES---YNLLFSESL 1207
Query: 3884 KIGPQLKELNPEEGEMVEEKYQK 3906
K QL+E VEEK K
Sbjct: 1208 K---QLQESQTSGDVKVEEKLDK 1227
Score = 36.2 bits (82), Expect = 0.91
Identities = 50/224 (22%), Positives = 101/224 (45%), Gaps = 16/224 (7%)
Query: 4709 MDALQALVDWLYKVEPQLAEDQPVHG-DLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSG 4767
M +Q L++W+ +++ QL D+ G DL V + ++ HK + + + +++ K S
Sbjct: 279 MKFVQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS- 335
Query: 4768 RELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWL 4827
E+ + T+ + +L L +++ + S +++ L+ V R T ++ WL
Sbjct: 336 -EIQMTAPLKLTYAE-KLHRLESQYAKLLNTSRNQERHLDTL--HNFVSRATNELI--WL 389
Query: 4828 SEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCI 4887
+E E+ +T + D H E M+++++K ++ S + E +L HP +
Sbjct: 390 NEKEEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 448
Query: 4888 TTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEE 4931
T I RA + +W Q Q +E + E A E +
Sbjct: 449 T-----IEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFND 487
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 1065 bits (2754), Expect = 0.0
Identities = 676/1955 (34%), Positives = 1074/1955 (54%), Gaps = 222/1955 (11%)
Query: 425 RLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLI 484
RLE+L QIAN++Q ++ CE+KL LA N LQ+D+ LESG Q E+++ YI ECE L+
Sbjct: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
Query: 485 RQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLEC--------------TNLYRKG 530
RQ +D+QIL D YYQ ++L RV +L+DE++ LR EC T L G
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
Query: 531 HFTSL-----ELVPPSTLT------TTHLKAEPLTKATHSSSTS---------------- 563
SL + + PS + T L + +T S TS
Sbjct: 176 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
Query: 564 ---------------------WFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMK 602
RKP+ ++ L+ + +E+E N++FV +LL+WV+EMQ++
Sbjct: 236 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
Query: 603 LERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLE 662
L+R EWG+DLPSVE LE +++H ++EE SS+KEA++ E +M+ +YAE L +LE
Sbjct: 296 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
Query: 663 TQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYF 722
+QY KL TS + RHL +LH FVSRAT ELIWLNEKEEEE+AYDWS+ N+NI+ K++Y
Sbjct: 356 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
Query: 723 SELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHV 782
+EL EL++K++ +S+Q+ AE L LENHPA+ T+EAY AA+Q+Q W+ QLC CVEQH+
Sbjct: 416 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
Query: 783 KENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSK 842
KENTAYF+FF+DA+E +LRNL+D+I+RKYSCD ++S+ +LEDL+Q+SM+EKE+L+Q K
Sbjct: 476 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
Query: 843 SSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTK 902
S++A+L+G++KTI+QLKPR+ D LK +I +KA+CDYRQIEITI K+DECVL +NS R K
Sbjct: 536 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
Query: 903 WKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNY 962
WKVISPTGNEAMVPSVCF +PPPNK+A+++A+R+EQ YQ V+ LWH+ H+N KS++SW+Y
Sbjct: 596 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
Query: 963 LRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEV 1022
L ++D ++ N+ +++ PGE Q++ NLQ+ +EDFL+DS++S +FS +D +LE+EV
Sbjct: 656 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
Query: 1023 EACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRD 1082
CK +Q L+KS E E++EE+V +YISE++NIRLRLE E R++++I+ + +RD
Sbjct: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIR----TPLERD 771
Query: 1083 AWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKM 1142
++ RI EQE +++L++L+ DL ++ KC+ F Q+ +SSSVPTLRSELN++++ M
Sbjct: 772 DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM 831
Query: 1143 DHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRH 1202
+ VY +S+ Y++KLKTV++++++ Q AE LVK YE KL +EE V+AD + +E STL+
Sbjct: 832 NQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 891
Query: 1203 WLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQ 1262
W S+V +K VF L++E+ KAK ++++M + ER+LD + ++EK QL ERW V Q
Sbjct: 892 WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 951
Query: 1263 LEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTAL 1322
++ R +LE I + L YR + L WI++ Q ++ Q E+S+ L+ QL+QQ L
Sbjct: 952 IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1011
Query: 1323 FAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAIT 1382
+EIE Q+K+D+CQK+++QYS VKDYELQ MTY+A V+SQQKSP KRRRM SS+D I
Sbjct: 1012 VSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII 1071
Query: 1383 QEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLA 1442
QEFMDLRTRYTALVTL TQ++K+ D+L+RLEEEE +E EH G S L
Sbjct: 1072 QEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEH--------GAYSDLL 1123
Query: 1443 RNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEK 1502
+ + KAT +LE L+ +++ + V+E L K ++ E+
Sbjct: 1124 Q--RQKAT-------------VLENSKLTGKISELERMVAE--------LKKQKSRVEEE 1160
Query: 1503 EKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSW 1562
K N L K ++ D S +++ ++ E +T+ +++ ++LE +
Sbjct: 1161 LPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQL 1220
Query: 1563 VGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQT 1622
+AE A + + L++N + L+D ++ + S + + MEE +
Sbjct: 1221 TIEAEAKRAAVE-ENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRR 1279
Query: 1623 KLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENK 1682
K E E L K+ + L + +VA+K+L+E L+ + ++ EN
Sbjct: 1280 KRDNEE-----ELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENA 1334
Query: 1683 KKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQC 1742
+ + + +G Q + E+L D N+ E
Sbjct: 1335 LPVCPITQATSCRAVTGLQQEHDKQKAEELK---------QQVDELTAANRKAE------ 1379
Query: 1743 EMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQ 1802
+ M+ EL + Q + + A+ D+ T + L+ +L E K+Q +Q
Sbjct: 1380 QDMRELTYELNALQLEKTSSEEKARLLKDKLDE--TNNTLRCLKLEL-ERKDQAEKGYSQ 1436
Query: 1803 SEAEL-KQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSF 1861
EL +Q+ + ++ +Q+ + + + ELE+++ + + R +
Sbjct: 1437 QLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAV 1496
Query: 1862 SEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCT 1921
+E I H + +SF++ KE + C
Sbjct: 1497 AEKNIQH-------------LNSQIHSFRDEKELERL-------------------QICQ 1524
Query: 1922 RLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQ 1981
R HL QF+ S + L ++A + N +K+ ++L
Sbjct: 1525 RKSDHLK------EQFEKSHEQLLQNIKAEKENNDKI-------------------QRLN 1559
Query: 1982 EELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQ 2041
EEL + E L++ ++ E + +Q +++I
Sbjct: 1560 EELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENI------------------- 1600
Query: 2042 KAIAQSQSVQESLESL-LQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKS 2100
+ + Q++Q+ E+L +Q+ G +Q L S E L K +QD R+
Sbjct: 1601 --VLEKQTIQQRCEALKIQADGFKDQ---------LRS--TNEHLHKQTKTEQDFQRKIK 1647
Query: 2101 SLE----ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQA 2156
LE ++ +V+ F + D ++Q EV +L ++EK +K+ Q
Sbjct: 1648 CLEEDLAKSQNLVSEFKQKCDQQN-IIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQ 1706
Query: 2157 EMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL--EHL 2214
+ L+ +L++ + + + F ++ + E+ ++ ++ L +
Sbjct: 1707 AQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKV 1766
Query: 2215 VTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKL-VRTFQ 2273
+TE G LD Q +++ + +KE E+ +EQ+ + + + +Q
Sbjct: 1767 ITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQ 1826
Query: 2274 KWLK-ETEGSIPPTETSMSAKELEKQI-EHLKSLL 2306
K K E E E +++++QI EH L+
Sbjct: 1827 KCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLV 1861
Score = 99.8 bits (247), Expect = 7e-20
Identities = 321/1712 (18%), Positives = 656/1712 (38%), Gaps = 307/1712 (17%)
Query: 1807 LKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI 1866
L Q T ++ KF+QD +W++ + +L+ G P S +
Sbjct: 268 LDQNLTEEEINMKFVQD---LLNWVDEMQVQLDRTEWGSDLP-----------SVESHLE 313
Query: 1867 SHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATE--RYTALHSKCTRLG 1924
+HK R + + E+S KE K SEI KL A + R + ++K
Sbjct: 314 NHKNVHRAIE-------EFESSLKEAKI-SEIQMTAPLKLTYAEKLHRLESQYAKLLNTS 365
Query: 1925 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTK----QL 1980
+ L H F + A + W+ E + VA D +A K +L
Sbjct: 366 RNQERHLDTLHNFVSRATNELIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAEL 418
Query: 1981 QEELAEHQVPVEKLQKVARDIMEIEGEPA----PDHRHVQETTDS-ILSHFQSLSYSLAE 2035
EL + + ++ +Q++A ++ +E PA +R +T S IL Q + + E
Sbjct: 419 MRELDQKEENIKSVQEIAEQLL-LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKE 477
Query: 2036 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2095
++ + +E+ + L +++ + SS+ +++ + +M+ K+++
Sbjct: 478 NTAYFEFF----NDAKEATDYLRNLKDAIQRKYSCDRSSSIHK--LEDLVQESMEEKEEL 531
Query: 2096 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQ 2155
+ KS T A L GK + Q L+ + + LK +P
Sbjct: 532 LQYKS-------------------TIANLMGKAKTIIQ------LKPRNSDCPLKTSIPI 566
Query: 2156 AEMFEHLSGKLQQFMENKSRML------------ASGNQPDQDITHFF-----QQIQELN 2198
+ ++ ++ + +++ + +GN+ F ++ +L
Sbjct: 567 KAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLA 626
Query: 2199 LEMEDQQENLDTLEH--------------LVTEL-----SSCGFALDLC--QHQDRVQNL 2237
+E Q +N+ TL H L+ E+ S+ + +HQ + NL
Sbjct: 627 NRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNL 686
Query: 2238 RKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEK 2297
+ F + + +E + + S QL+ K V +++ +E + + E E+
Sbjct: 687 QSRFEDFLEDSQESQVFSGSDITQLE---KEVNVCKQYYQEL----------LKSAEREE 733
Query: 2298 QIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVN 2357
Q E + +L L E NC+ + LI +I P + + SV +
Sbjct: 734 QEESVYNLYISEVRNIRLRLE-NCE----DRLIRQIRTPLERD-------DLHESVFRIT 781
Query: 2358 GYHTCK-DLTEIQCDMSDVNLKYEKL------GGVLHERQESLQAILNRMEEVHKEANSV 2410
K +L ++ D+ + K E+ + + L +L M +V+ +++
Sbjct: 782 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 841
Query: 2411 LQWLESKEEVLKSMDAMSSPTKT--------ETVKAQAESNKAFLAELEQ---------- 2452
+ L++ VLK+ A + K E V A + + ++ L+Q
Sbjct: 842 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 901
Query: 2453 ----NSPKIQKVKEALAGLLVTYPNSQEAENWKKIQ-EELNSRWERATEVTVARQRQLEE 2507
++QK K + TY +W K + ++L RW+ R R LE
Sbjct: 902 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 961
Query: 2508 SASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNM-LNAQKQQVQFMLKEFEARRQQ 2566
L ++ L W+ + E + + + L Q Q + ++ E E ++ +
Sbjct: 962 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1021
Query: 2567 HEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQY 2626
++ + A+ D L T + + S + V+ +S I + + T+Y
Sbjct: 1022 MDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY 1081
Query: 2627 QELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSE--IRSDLEQLDHE-VKEAQT 2683
L+ +++ ++ G L + E +K+ +ETSE SDL Q V E
Sbjct: 1082 TALVTLMTQYIKFAGDSLK-----RLEEEEIKR-CKETSEHGAYSDLLQRQKATVLENSK 1135
Query: 2684 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQA--------ALASTQQ 2735
L ++S L + + ELKK+ V L + + A + + + Q + + +
Sbjct: 1136 LTGKISEL---ERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESE 1192
Query: 2736 FQQMFDELRTWLDDKQSQQ--------------AKNCPISAKLERLQSQLQENEEFQKSL 2781
+Q EL T + +K++ + AK + L ++QL+EN +++L
Sbjct: 1193 AKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTL 1252
Query: 2782 NQHSGSYEVIVAE------------------GESLLLSVPPGE----------EKRTLQN 2813
H ++ + + E LL + E EK+ +
Sbjct: 1253 EDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEK 1312
Query: 2814 QLVELKNHWEELSKKTADRQSRLKDC-------------------MQKAQKYQWHVEDLV 2854
Q +EL+ + + R++ L C QKA++ + V++L
Sbjct: 1313 QKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELT 1372
Query: 2855 PWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD 2914
+ M EL L+ +QLE + KA L + L E N+ + + D
Sbjct: 1373 AANRKAEQDMRELTYELNALQLEKTSSEEKARL----LKDKLDETNNTLRCLKLELERKD 1428
Query: 2915 EDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKH----- 2969
+ + G +Q + + +L TG EE Q + ++ +N + ++E H
Sbjct: 1429 Q-----AEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKL 1483
Query: 2970 QLEIFDALGSQACSNKNLEKLRAQ---------QEVLQALEPQVDYLRNFTQGL------ 3014
Q E+ + A + KN++ L +Q E LQ + + D+L+ +
Sbjct: 1484 QREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQ 1543
Query: 3015 -VEDAPDGSDASQLLHQ--------AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR 3065
++ + +D Q L++ AE+ +Q+ E+ ++ N +MM+ +++ +
Sbjct: 1544 NIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQ-RIQAESENIVL 1602
Query: 3066 VREMFSQLAD-LDDELDGMGAIGRDT-DSLQSQIEDVRLFLNKIHVLKLDIEASE---AE 3120
++ Q + L + DG R T + L Q + + F KI L+ D+ S+ +E
Sbjct: 1603 EKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSE 1662
Query: 3121 CRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND 3180
+ +++ + + K+E+ LN + E + +++++L +V++ +LK + D
Sbjct: 1663 FKQKCDQQNII-IQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQD 1721
Query: 3181 ATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK 3240
E + ++ + ++ FK +E ++ KL + + + I
Sbjct: 1722 ELHLKTIEEQM---THRKMVLFQEESGKFKQSAEEFRKKME-KLMESKVITENDISGIRL 1777
Query: 3241 DCDVQGLEHDMEEINARWNTLN-KKVAQRIAQLQEALL--------HCGKFQDALEPLLS 3291
D E+ + NA+ N K++ +++ Q +E + H K Q + L++
Sbjct: 1778 DFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIA 1837
Query: 3292 WLADTEEL--IANQKPPSAEYKVVKAQIQEQK 3321
+ E L +Q+ E+++V Q + QK
Sbjct: 1838 QKREVENLKQKMDQQIKEHEHQLVLLQCEIQK 1869
Score = 84.7 bits (208), Expect = 2e-15
Identities = 311/1730 (17%), Positives = 673/1730 (38%), Gaps = 299/1730 (17%)
Query: 2612 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 2671
+SS +DQ + + + +QDL V + +L S P +V+ LE + +
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLP-SVESHLENHKNVHRAI 322
Query: 2672 EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRIN---RLQA 2728
E+ + +KEA+ I E + LK T A L LE A +N +
Sbjct: 323 EEFESSLKEAK---------ISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQER 370
Query: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 2788
L + F WL++K+ ++ S + + + + E + L+Q +
Sbjct: 371 HLDTLHNFVSRATNELIWLNEKEEEEVAY-DWSERNTNIARKKDYHAELMRELDQKEENI 429
Query: 2789 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEEL----------------------- 2825
+ + E LLL P + T++ ++ W +
Sbjct: 430 KSVQEIAEQLLLENHPA--RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFND 487
Query: 2826 SKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA 2885
+K+ D LKD +Q+ KY + +ED + E + E L
Sbjct: 488 AKEATDYLRNLKDAIQR--KYSCDRSSSIHKLEDLVQESME--------EKEELLQYKST 537
Query: 2886 MLNEVEKRRSLLEILNSAADILINSS----------EADEDGIRDEKAGINQNMDAVTEE 2935
+ N + K ++++++ +D + +S + + +D++ + N +
Sbjct: 538 IANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK 597
Query: 2936 LQAKTGSL--------------EEMTQRLREFQESFKNI----------EKKVEGAKHQL 2971
+ + TG+ +E ++ ++N+ K V + +
Sbjct: 598 VISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLI 657
Query: 2972 EIFDALGSQACSNKNLEKLRAQQEVLQALEPQV-DYLRNFTQGLVEDAPDGSDASQLLHQ 3030
D + + ++ Q+VL L+ + D+L + + V GSD +QL +
Sbjct: 658 NEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFS---GSDITQLEKE 714
Query: 3031 AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHC-RVREMFSQLADLDDELDGMGAIGRD 3089
V +Q + E+ + E + E + + VR + +L + +D L
Sbjct: 715 VNVCKQYYQELLKSAER-----EEQEESVYNLYISEVRNIRLRLENCEDRL--------- 760
Query: 3090 TDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGK 3149
I +R L + + E+ R +E+ +L LK +L + +C +
Sbjct: 761 -------IRQIRTPLERD-------DLHESVFRITEQEKLKKELERLKDDLGTITNKCEE 806
Query: 3150 LTERGKAR------QEQLELTLGRVEDFYR-------KLKGLNDATTAAEEAEALQWVVG 3196
+ A + +L + L + Y KLK +N + AEAL +
Sbjct: 807 FFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYE 866
Query: 3197 TEVEIINQQLAD---------------FKMFQKEQV-DPLQMKLQQVNGLGQGLIQS-AG 3239
T++ +AD ++ +K QV L+ +LQ+ + + ++
Sbjct: 867 TKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKE 926
Query: 3240 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLAD---T 3296
+D D + +++ RW ++ ++ R+ L+ ++D PL W+ T
Sbjct: 927 RDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETT 986
Query: 3297 EELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3356
+ I +P ++ K + Q+ +QK+L ++ +++ +D Q + SA + D E
Sbjct: 987 QRKIQENQPENS--KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQ 1042
Query: 3357 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3416
T ++ + K+ ++++++ L Q E + + + ++ + G
Sbjct: 1043 TMTYRAM----VDSQQKSPVKRRRMQSSADLIIQ--EFMDLRTRYTALVTLMTQYIKFAG 1096
Query: 3417 TQTAKIQQQIIRHKALEEDIENHA-TDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQAR 3475
+++++ I K +E E+ A +D+ Q K + E L+ KI L+
Sbjct: 1097 DSLKRLEEEEI--KRCKETSEHGAYSDLLQRQK--------ATVLENSKLTGKISELERM 1146
Query: 3476 YSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQH 3535
+E++ ++ + +++ L R E+E L + + + + ++ + + +Q+
Sbjct: 1147 VAELK----KQKSRVEEELPKVREAAENE------LRKQQRNVEDISLQKIRAESEAKQY 1196
Query: 3536 ADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVT---- 3591
L E IV K+ ++ ++ + L + + ++E L + + + T T
Sbjct: 1197 RREL---ETIVREKEAAERELERVRQLTIEAEAKRA-AVEENLLNFRNQLEENTFTRRTL 1252
Query: 3592 ------SSKALRTLEQAR----QLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIP 3641
+L LEQ + + + + EEL ++++E++LA +Q+
Sbjct: 1253 EDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQ-------KQVA 1305
Query: 3642 QFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTI 3701
+ Q ++K+ K E+ R + + L + P + E K ++ +
Sbjct: 1306 EKQLKEKQ-KIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEEL 1364
Query: 3702 GQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSI 3761
Q+VDE+ AA ++++Q + EL A K + RL +D+ + +
Sbjct: 1365 KQQVDELTAANRKAEQDMRELTYELN--ALQLEKTSSEEKARLLKDKLDETNNTLRCLKL 1422
Query: 3762 DIIRHKDSMDELFSHRSEIFG-----TCGEEQKTVLQEKTESLIQQYEAISL--LNSER- 3813
++ R KD ++ +S + G T G+ ++ + + I++ + L LN E+
Sbjct: 1423 ELER-KDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKG 1481
Query: 3814 -----YARLERAQVLVNQ-FWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEM-R 3866
R+ RA + + ++ + +E Q+ DH L++Q E+
Sbjct: 1482 KLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDH--LKEQFEKSHE 1539
Query: 3867 QLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQ------------------KAE 3908
QL ++I K + DK+ ++ +L++ N E EM+++K + ++E
Sbjct: 1540 QLLQNIKAEKENNDKIQRLNEELEKSN-ECAEMLKQKVEELTRQNNETKLMMQRIQAESE 1598
Query: 3909 NMYAQIKEEVRQRALALD-EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVD 3967
N+ + K+ ++QR AL +A Q+ ++ + +T ++ +++ + ++
Sbjct: 1599 NIVLE-KQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIK---CLEEDLA 1654
Query: 3968 KIRECISDNK-----------SATVELEKLQPSFEAL---KRRGEELIGRSQGADKDL-- 4011
K + +S+ K + E+ L A KRRGE+ + Q ++L
Sbjct: 1655 KSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714
Query: 4012 AAKEIQDKLD-----------QMVFFWED---IKARAEEREIKFLDVLELAEKFWYDMAA 4057
K++QD+L +MV F E+ K AEE K ++E +
Sbjct: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLME----------S 1764
Query: 4058 LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET----IKEETDGLHEELEFIRILGADL 4113
+ T D I D S + S ++ + ET ++ + E+++ + + A+
Sbjct: 1765 KVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANH 1824
Query: 4114 IFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDT 4163
C + E E+ E+ N + +++ KE +L +Q +Q + T
Sbjct: 1825 YQKCQKLE-DELIAQKREVENLKQKMDQQIKEHEHQLV-LLQCEIQKKST 1872
Score = 70.5 bits (171), Expect = 4e-11
Identities = 294/1718 (17%), Positives = 668/1718 (38%), Gaps = 256/1718 (14%)
Query: 931 EMASRVEQSYQKVM--ALWHQLHVNT--------KSLISWNYLRKDLDLVQTWNLEKLRS 980
E R+E Y K++ + + H++T + + W +++ ++ W+
Sbjct: 349 EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 408
Query: 981 SAPGECH-QIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEE-----VEACKARFQ---- 1030
+ + H ++M+ L E+ + +A++L LE +EA +A Q
Sbjct: 409 ARKKDYHAELMRELDQKEENIKS------VQEIAEQLLLENHPARLTIEAYRAAMQTQWS 462
Query: 1031 ---HLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDN 1087
L + +E KE T + ++ K L + + ++ SS + +D
Sbjct: 463 WILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHK--LED- 519
Query: 1088 ALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYG 1147
+ E +E+L Q +S + + K + + P +S P
Sbjct: 520 --LVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCP------------------ 559
Query: 1148 LSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDV 1207
LKT + +++I D + EI + +++ + ++ A W + S
Sbjct: 560 --------LKT-SIPIKAICDYRQI----EITIYKDDECVLANNSHRAKWKVI----SPT 602
Query: 1208 KDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQE--RWHRVIAQLE- 1264
++ V SV K + +R+ + L + E ++ WH +I +++
Sbjct: 603 GNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDR 662
Query: 1265 IRQSELESIQEVL-GDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALF 1323
IR S + SI+ +L G+++ L E+ + + D L ++++ +
Sbjct: 663 IRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYY 722
Query: 1324 AEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQ 1383
E+ ++ + +Q + Y + V++ L+L + + Q ++P +R + S IT+
Sbjct: 723 QELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITE 782
Query: 1384 EFM---DLRTRYTALVTLTTQHVKYISDA-----LRRLEEEEKVVEEEKQE-------HV 1428
+ +L L T+T + ++ S A + L E VV + + ++
Sbjct: 783 QEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI 842
Query: 1429 EKVKELLGWVSTLARNTQGKATSSETKEST--DIEKAILEQQVLSEELTTKKEQVSEAIK 1486
+K+K V+ + +NTQ + E+ + E I ++ + ++T K+ SE +
Sbjct: 843 DKLKT----VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDE 898
Query: 1487 TSQIFLAKHGHKLSEKEKKQISEQLNALNKA-------YHDLCDGSANQLQQLQSQLAHQ 1539
Q+F H + ++ K IS+++ K + + D + Q + Q+ ++
Sbjct: 899 KRQVF---HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
Query: 1540 TEQ-----KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKD 1594
K+L+ ++T H L+D V +R + +Q ++ + L + + + +
Sbjct: 956 LRDLEGIGKSLKYYRDTYHP-LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE 1014
Query: 1595 LQ------DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQY---EA 1645
++ D+ Q A ++ VKD E + + ++ + ++ + Q+ E
Sbjct: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
Query: 1646 LQEETR------VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSG 1699
+ TR + + ++ A S + E E+ K KE +E+ D L +V
Sbjct: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV-LEN 1133
Query: 1700 GQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQN- 1758
+L + +E++ A L+K ++ E+L K + +A EL QQ+N
Sbjct: 1134 SKLTGKISELERMV-AELKKQK----------SRVEEELPK---VREAAENELRKQQRNV 1179
Query: 1759 --FILATQSAQAFLDQHGHNLTP--EEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ 1814
L A++ Q+ L E++ +++L +++ + A+ A + + +
Sbjct: 1180 EDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFR 1239
Query: 1815 DELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRF 1874
++L++ + E L+R + L ++ + L L+R+ E+++
Sbjct: 1240 NQLEENTFTRRTLEDHLKRKDLSLNDLEQ---QKNKLMEELRRKRDNEEELL-------- 1288
Query: 1875 VTISGQKVLDMENSFKEGKEPSEIGNLVKDKLK-DATERYTALHSKCTRLGSHLNMLLGQ 1933
+ + ME K+ +E K K++ +A + T + C + +
Sbjct: 1289 -----KLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPI--- 1340
Query: 1934 YHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAE--HQVPV 1991
A S +A + + +K ++ + + E A ++ ++++ E +++
Sbjct: 1341 -----TQATSCRA-VTGLQQEHDKQKAEELKQQ---VDELTAANRKAEQDMRELTYELNA 1391
Query: 1992 EKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQ 2051
+L+K + + E A R +++ D + + L L ER +K SQ ++
Sbjct: 1392 LQLEKTSSE------EKA---RLLKDKLDETNNTLRCLKLEL-ERKDQAEKGY--SQQLR 1439
Query: 2052 ESLESLLQSIGEVEQNL-EGKQVSSLSSGVIQEALATNM---KLKQDIAR-------QKS 2100
E L Q+ G+ E+ + E + + E + N KL++++ R +
Sbjct: 1440 ELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEK 1499
Query: 2101 SLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQ-------QQEKESSLKKLL 2153
+++ + F + + + Q K + ++FE+ Q ++E +++L
Sbjct: 1500 NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLN 1559
Query: 2154 PQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEH 2213
+ E + L+Q +E +R N+ + + + + LE + Q+ + L+
Sbjct: 1560 EELEKSNECAEMLKQKVEELTRQ---NNETKLMMQRIQAESENIVLEKQTIQQRCEALK- 1615
Query: 2214 LVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQ 2273
+ + GF L + + K + Q+ +K E+D + Q + EF++
Sbjct: 1616 ----IQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQN 1671
Query: 2274 KWLKETEGSIPPTETSMSAKELEK------------QIEHLKSLL---DDWASKGTLVEE 2318
++ T+ + ++A + EK Q++ L + L D T+ E+
Sbjct: 1672 IIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQ 1731
Query: 2319 INCKGTSL---ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDV 2375
+ + L E+ + +A + + K ++ S + ++G D +Q + S
Sbjct: 1732 MTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRL--DFVSLQQENSRA 1789
Query: 2376 NLKYEKLGGVLHERQESLQAILNRMEE-VHKEANSVLQWLESKEEVL----------KSM 2424
+ + E + LQ +M++ H EAN + + ++E++ + M
Sbjct: 1790 QENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKM 1849
Query: 2425 DAMSSPTKTETVKAQAESNK-------AFLAELEQNSPKIQ---KVKEALAGLLVTYPNS 2474
D + + V Q E K F + E + Q ++ G L P S
Sbjct: 1850 DQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRS 1909
Query: 2475 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHL 2512
W + + L +W+ + ++ Q + + L
Sbjct: 1910 -PLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPL 1946
Score = 63.2 bits (152), Expect = 7e-09
Identities = 230/1166 (19%), Positives = 428/1166 (36%), Gaps = 235/1166 (20%)
Query: 3417 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARY 3476
T+ K+++++ R K I N + S+ +L S E V+ + ++ + +
Sbjct: 781 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRS--ELNVVLQNMNQVYSMS 838
Query: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDK-----LSSVFVKDFKQDVL 3531
S D+ +L + L E ++ A + DK L S +K ++ +V
Sbjct: 839 STYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIST-LKQWRSEVD 897
Query: 3532 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLI---QEKLDGIKTRYADI 3588
++ H AL +E+ K D+ K T E L +EK D + R+ ++
Sbjct: 898 EKRQVFH-ALEDELQKAKAISDEMFK--------TYKERDLDFDWHKEKADQLVERWQNV 948
Query: 3589 TVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQK 3648
V LR LE + ++ TY L W+++VE + Q+ Q
Sbjct: 949 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR-------------KIQENQP 995
Query: 3649 ELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEI 3708
E K L + N+Q LVS+ I + ++
Sbjct: 996 ENSK--------------------------------TLATQLNQQKMLVSE-IEMKQSKM 1022
Query: 3709 DAAIQRSQQYEQAA-DAELAWVAETKRKLM---ALGPIRLEQDQTTAQLQVQKAFSIDII 3764
D + ++QY D EL + T R ++ P++ + Q++A L +Q+ +
Sbjct: 1023 DECQKYAEQYSATVKDYELQTM--TYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL--- 1077
Query: 3765 RHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTE------------SLIQQYEAISLLNSE 3812
+ L + ++ G+ K + +E+ + L+Q+ +A L NS+
Sbjct: 1078 --RTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSK 1135
Query: 3813 ---RYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLR 3869
+ + LER + + EE P + E +LR+QQ +
Sbjct: 1136 LTGKISELERMVAELKKQKSRVEEELPKVREAA------------ENELRKQQRNV---- 1179
Query: 3870 ESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAV 3929
E I+ K + K + E E E E + ++ Q+ E + A++E
Sbjct: 1180 EDISLQKIRAESEAKQYRRELETIVREKEAAERELERVR----QLTIEAEAKRAAVEE-- 1233
Query: 3930 SQSTQITEFHDKIEPMLETLENLSSRLRMPPL----IPAEVDKIRECISDNKSATVELEK 3985
+ F +++E T L L+ L + + +K+ E + + EL K
Sbjct: 1234 ----NLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289
Query: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045
L +K+ ++L + Q A+K L K+ K+ +++AR + EI++
Sbjct: 1290 L------IKQMEKDLAFQKQVAEKQLKEKQ---KI--------ELEARRKITEIQYTCRE 1332
Query: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105
A + Q HD + +KQQV+ + + EL +
Sbjct: 1333 NALPVCPITQATSCRAVTGLQQ-EHDKQK----AEELKQQVDELTAANRKAEQDMRELTY 1387
Query: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQ 4165
+ L E + ++ +DE NN L +LE LE QA Y L+
Sbjct: 1388 -ELNALQLEKTSSEEKARLLKDKLDETNNTLRCL------KLE-LERKDQAEKGYSQQLR 1439
Query: 4166 AMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKK 4225
+ L+ T K ++ + E + K Q+E+E LNH+ K
Sbjct: 1440 ELGRQLNQTTGK-------------AEEAMQEASDLKKIKRNYQLELESLNHE----KGK 1482
Query: 4226 ATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE 4285
E DR I R K++ ++L +I + + E L + Q + H +
Sbjct: 1483 LQREVDR-ITRAHAVAEKNI-QHLNSQIHSFRDEKELERLQICQRKS---------DHLK 1531
Query: 4286 ELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLR 4345
E + H L ++ A + + + + E
Sbjct: 1532 EQFE----------------KSHEQLLQNIKAEKENNDKIQRLNEE-------------- 1561
Query: 4346 SRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASK-PTG 4404
LE N+C E + QK EE +Q T Q +E E+ +LE ++ + A K
Sbjct: 1562 --LEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQAD 1619
Query: 4405 GLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQK 4464
G + R T+ L+ Q K +++ + ++ L D +K++ V+ +QK
Sbjct: 1620 GFKDQLR---STNEHLHKQTKTEQDF------QRKIKCLEED----LAKSQNLVSEFKQK 1666
Query: 4465 WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI 4524
+ ++ K +E NL E S +E EQ + + LN L ++
Sbjct: 1667 CDQQNIIIQNTK---KEVRNLNAELNASKEE----KRRGEQKVQLQQAQVQELNNRLKKV 1719
Query: 4525 EE--HKVFANEVNAHRDQIIELDQTG 4548
++ H E HR ++ +++G
Sbjct: 1720 QDELHLKTIEEQMTHRKMVLFQEESG 1745
Score = 56.6 bits (135), Expect = 7e-07
Identities = 145/795 (18%), Positives = 295/795 (37%), Gaps = 150/795 (18%)
Query: 4164 LQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFK--VEVYQQQIEMEKLNHQGEL 4221
+Q + +W+D ++L G+DL +V+ L K +E ++ ++ K++
Sbjct: 282 VQDLLNWVDEMQVQL-DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 340
Query: 4222 MLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWL 4281
K T E H E+ K+ + E L L F + WL
Sbjct: 341 APLKLT-----------YAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWL 389
Query: 4282 THTEELLDAQRPISGDPKVIEVELAK----HHVLKNDVLAHQATVETVNKAGNELLESSA 4337
EE ++ D +A+ H L ++ + +++V + +LL +
Sbjct: 390 NEKEE-----EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH 444
Query: 4338 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHS--EIEDFLLELT---R 4392
++ + AM W +LQ + EQ ++ + F+ E D+L L +
Sbjct: 445 -PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 503
Query: 4393 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML-LSRDDSGSG 4451
+ S L + +E ++ EL + T L+ K + ++ L +S
Sbjct: 504 RKYSCDRSSSIHKLEDLVQESMEEKEELLQY----KSTIANLMGKAKTIIQLKPRNSDCP 559
Query: 4452 SKTEQSVALL-----------------------EQKWHVVSSKMEERKSKL--------- 4479
KT + + KW V+S E
Sbjct: 560 LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPN 619
Query: 4480 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 4539
+EA++LA + Q++ N LTL +S + + + NE++ R
Sbjct: 620 KEAVDLANRIE---QQYQNVLTLWHES-----------HINMKSVVSWHYLINEIDRIRA 665
Query: 4540 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER----GRSLDDARKRA 4595
+ +K + + ++ NL QSR+E ++ S E G + K
Sbjct: 666 SNVA------SIKTMLPGEHQQVLSNL----QSRFEDFLEDSQESQVFSGSDITQLEKEV 715
Query: 4596 ---KQFHEAWKKLIDWLEDAESHLDS--------ELEISNDPDKIKLQLSKHKEFQKTLG 4644
KQ+++ K + E ES + L + N D++ Q+ E
Sbjct: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLE------ 769
Query: 4645 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ--------- 4695
+ ++++ R + E+ L ++ ++L + LG + +K + ++
Sbjct: 770 -RDDLHESVFR----ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 824
Query: 4696 ----HKLEEALLFSGQFMDALQAL---------VDWLYKV-EPQLAEDQPVHGDLDLVMN 4741
+ + S ++D L+ + + L K+ E +L E++ V D + + N
Sbjct: 825 NVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIEN 884
Query: 4742 LMDAHKVFQKELGKRTGTVQVL-------KRSGRELIENSRD---DTTWVKGQLQELSTR 4791
L+ K ++ E+ ++ L K E+ + ++ D W K + +L R
Sbjct: 885 LISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVER 944
Query: 4792 WDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEALQSL 4850
W V ++ LE K + +RDT H L +W+ + E T R + P++++ L +
Sbjct: 945 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1004
Query: 4851 IDTHKEFMKKVEEKR 4865
++ K + ++E K+
Sbjct: 1005 LNQQKMLVSEIEMKQ 1019
Score = 47.8 bits (112), Expect = 3e-04
Identities = 122/594 (20%), Positives = 217/594 (36%), Gaps = 84/594 (14%)
Query: 4318 HQATVETVNKAGNELLESS------AGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4371
HQ + + + LE S +G D + L + Q ++ +L+ E RE+Q +S
Sbjct: 679 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE-REEQEES 737
Query: 4372 TLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY---SQLKAKE 4428
+ SE+ + L L E +L T E+ D H ++ Q K K+
Sbjct: 738 VYNL---YISEVRNIRLRLENCEDRLIRQ------IRTPLERDDLHESVFRITEQEKLKK 788
Query: 4429 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE------EA 4482
E +L D + ++ S + SV L + +VV M + S +
Sbjct: 789 E-LERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKT 847
Query: 4483 LNLATEFQNSLQEFINW--LTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 4540
+NL + + + + L E+ IA N + + I K + +EV+ R
Sbjct: 848 VNLVLKNTQAAEALVKLYETKLCEEEAVIADK-----NNIENLISTLKQWRSEVDEKRQV 902
Query: 4541 IIELDQTGNQLKFLSQKQ---------DVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 4591
L+ + K +S + D K + RW+ V + R R L+
Sbjct: 903 FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 962
Query: 4592 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIK---LQLSKHKEFQKTLGGKQP 4648
K K + + + L DW++ E+ E N P+ K QL++ K + KQ
Sbjct: 963 GKSLKYYRDTYHPLDDWIQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVSEIEMKQS 1020
Query: 4649 VYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQF 4708
D + T+ + Q + R D+ V+R+ A L +F
Sbjct: 1021 KMDECQKYAEQY-SATVKDYELQTM-----TYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
Query: 4709 MD------ALQALV--------DWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG 4754
MD AL L+ D L ++E + + + +L+ K E
Sbjct: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENS 1134
Query: 4755 KRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAE 4814
K TG + L+R EL + K +++E +L +++ + KQ
Sbjct: 1135 KLTGKISELERMVAELKKQ--------KSRVEE---------ELPKVREAAENELRKQQR 1177
Query: 4815 VFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 4868
D + SEA+Q R + + EA + ++ ++ + E KR V
Sbjct: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAV 1231
Score = 45.1 bits (105), Expect = 0.002
Identities = 157/917 (17%), Positives = 328/917 (35%), Gaps = 155/917 (16%)
Query: 651 HTSYAETLGKLET---QYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYD 707
H +Y++ L + + + KL S R + L K SR EL + E E EL
Sbjct: 1116 HGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQ 1175
Query: 708 WSDNNSNISAKR--------NYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEA 759
N +IS ++ Y EL + EK+ R L+ +L ++E + VE
Sbjct: 1176 -QRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQL-TIEAEAKRAAVEE 1233
Query: 760 YSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNT 819
++QL+ +E H+K +LE L + ++RK +
Sbjct: 1234 NLLNFRNQLEENTFTRRTLEDHLKRKDL------SLNDLEQQKNKLMEELRRKRDNEEEL 1287
Query: 820 S--LSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRS---PDHVLKNTISVK 874
+ ++E L E+ ++ K + R T +Q R P + S +
Sbjct: 1288 LKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCR 1347
Query: 875 AVCDYRQI--------------EITICKN-------------DECVLEDNSQRTKWKVIS 907
AV +Q E+T + LE S K +++
Sbjct: 1348 AVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLK 1407
Query: 908 PTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSY-QKVMALWHQLHVNTKSLISWNYLRKD 966
+E C + KD + E+ Y Q++ L QL+ T D
Sbjct: 1408 DKLDETNNTLRCLKLELERKD------QAEKGYSQQLRELGRQLNQTTGKAEEAMQEASD 1461
Query: 967 LDLVQT---WNLEKLRSSAPGECHQIMKNLQAHY--EDFLQDSRDSVLFSVADRLRLEEE 1021
L ++ LE L ++ + +AH E +Q +S + S D LE
Sbjct: 1462 LKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHL-NSQIHSFRDEKELER- 1519
Query: 1022 VEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDR 1081
++ C+ + HL + E + E+ + + + N +++ E + + +
Sbjct: 1520 LQICQRKSDHLKEQFE-KSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEE 1578
Query: 1082 DAWQDNALRI------AEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSEL 1135
Q+N ++ AE E+ + Q ++ +A+ ++ D F Q S++
Sbjct: 1579 LTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTN--------- 1629
Query: 1136 NLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEA 1195
+H++ + + + + + + ++ LV ++ K Q+ +++ +
Sbjct: 1630 -------EHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTK---- 1678
Query: 1196 HWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQER 1255
+V++ N+ + EE + + + E N L++ +Q+
Sbjct: 1679 ---------KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKK-------VQDE 1722
Query: 1256 WHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQ 1315
H + ++ ++ QE G ++ +A++ K + +S+V++E
Sbjct: 1723 LHLKTIEEQMTHRKMVLFQEESGKFKQ------------SAEEFRKKMEKLMESKVITEN 1770
Query: 1316 -LSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRM 1374
+S F +++ ++ + K + T +K+ E QL Y+ ++ Q
Sbjct: 1771 DISGIRLDFVSLQQENSRAQENAKLCE---TNIKELERQLQQYREQMQQGQH-------- 1819
Query: 1375 LSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKEL 1434
+ H + L +++ VE KQ+ +++KE
Sbjct: 1820 -----------------------MEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEH 1856
Query: 1435 LGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAK 1494
+ L Q K+T+ + D E + E Q E + + ++ + +
Sbjct: 1857 EHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQ 1916
Query: 1495 HGHKLSEKEKKQISEQL 1511
L EK + ++ EQ+
Sbjct: 1917 EPQPLEEKWQHRVVEQI 1933
Score = 39.3 bits (90), Expect = 0.11
Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 12/191 (6%)
Query: 4802 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 4861
K S L+Q L + E+ V LL W+ E + L R D +++S ++ HK + +
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLD-RTEWGSDLPSVESHLENHKNVHRAI 322
Query: 4862 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 4921
EE + A + E+ + T + + +++ ++L ++ ++ L+T L
Sbjct: 323 EEFESSLKEA-KISEIQMTA---PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDT-LHN 377
Query: 4922 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDR 4981
V+ A L W+ E + D NI R K H M E+ +K+ ++
Sbjct: 378 FVSRA---TNELIWLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQKEENIKS 431
Query: 4982 VTKTYKRKNIE 4992
V + ++ +E
Sbjct: 432 VQEIAEQLLLE 442
Score = 36.2 bits (82), Expect = 0.91
Identities = 50/224 (22%), Positives = 101/224 (45%), Gaps = 16/224 (7%)
Query: 4709 MDALQALVDWLYKVEPQLAEDQPVHG-DLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSG 4767
M +Q L++W+ +++ QL D+ G DL V + ++ HK + + + +++ K S
Sbjct: 279 MKFVQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS- 335
Query: 4768 RELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWL 4827
E+ + T+ + +L L +++ + S +++ L+ V R T ++ WL
Sbjct: 336 -EIQMTAPLKLTYAE-KLHRLESQYAKLLNTSRNQERHLDTL--HNFVSRATNELI--WL 389
Query: 4828 SEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCI 4887
+E E+ +T + D H E M+++++K ++ S + E +L HP +
Sbjct: 390 NEKEEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 448
Query: 4888 TTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEE 4931
T I RA + +W Q Q +E + E A E +
Sbjct: 449 T-----IEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFND 487
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 557 bits (1435), Expect = e-157
Identities = 451/1830 (24%), Positives = 861/1830 (47%), Gaps = 177/1830 (9%)
Query: 579 SSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKE 638
S DE E L W+ + + +++ WG DL SVE + + + IH S+ +
Sbjct: 178 SGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDY------ 231
Query: 639 ARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNE 698
R K+ + A + +LE +Y L + S RM HL+ L + + E++W+N+
Sbjct: 232 -RWQLDKIKADLREKSA--IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIND 288
Query: 699 KEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVE 758
EEEEL YDWSD N+NI+ K+ FS +LE K+ L+ ++ L L HPA +E
Sbjct: 289 CEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIE 348
Query: 759 AYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHN 818
AY +Q+Q W+ Q+ C++ H+KEN AYFQFF +A+ E++L+ LQDSI++KY CD N
Sbjct: 349 AYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKN 408
Query: 819 TSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCD 878
L L + +++ E+E++++ K V +LV +SK IVQLKPR+PD+ I ++A+CD
Sbjct: 409 MPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCD 468
Query: 879 YRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQ 938
Y+Q + + K DEC+L+DN++R+KW V P G + +VPSV +IPPPN A++++ ++EQ
Sbjct: 469 YKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQ 528
Query: 939 SYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYE 998
Y+ ++ALW+QL++N KSL+SW+Y D++ ++ + KL++ + + + +L+ HY+
Sbjct: 529 YYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQ 588
Query: 999 DFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYIS------- 1051
+F+++S+ S +F D+ +++ + + +Q L+ + + +TV I+
Sbjct: 589 EFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQD 648
Query: 1052 ----------------------ELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNAL 1089
EL+ IR ++E E R+ + LA D+ + +
Sbjct: 649 VNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLA----DQGSSHHITV 704
Query: 1090 RIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLS 1149
+I E + Q D Q + L+ + +F S L++E+ L +K++++ G++
Sbjct: 705 KINELKSVQNDSQAIAEVLNQLKDMLANFR----GSEKYCYLQNEVFGLFQKLENINGVT 760
Query: 1150 TVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKD 1209
YLN L TV ++++I E ++K YE +L++EE V DL +EA+ L+ +D+
Sbjct: 761 DGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNL 820
Query: 1210 KNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSE 1269
K S+ + + E+ KA+ + Q S+ P +LDL ++ EK +QL +RW R+ Q++ R +
Sbjct: 821 KKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWD 880
Query: 1270 LESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERN 1329
LE + L +YR + KW+ + +Q+ ++ + DS + L++Q L +EI
Sbjct: 881 LEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGK 940
Query: 1330 QTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLR 1389
+ K ++ QK ++ + +KDYELQL +Y + +E+ P KR + S S I QE D+
Sbjct: 941 RDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVH 1000
Query: 1390 TRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKA 1449
RY L+T + + +++S+ L+ LE+ + K +E ++E L LAR+ A
Sbjct: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKL-----KNTKIEVLEEEL----RLARD----A 1047
Query: 1450 TSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI--FLAKHGHKLSEKEKKQI 1507
S ++ +++ + + Q + K + E + +++ AK + K++
Sbjct: 1048 NSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKEL 1107
Query: 1508 SEQLNAL----------NKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE 1557
+E++ L K+ D D N QLQ A Q E++ L Q+ + ++
Sbjct: 1108 NEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQK--ARQCEKENLGWQKLESEKAIK 1165
Query: 1558 DLCSWVGQAERALAGHQG---RTTQQDLSALQKN-QSDLKDLQDDIQNRATSFATVVKDI 1613
+ + + R L +G R + +L+ ++ + ++ +L++ + T +K+I
Sbjct: 1166 EK-EYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEI 1224
Query: 1614 EGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSK 1673
+E+ +K +L L + K++ L + A ++ A +ALQQ+
Sbjct: 1225 -SMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKA---- 1279
Query: 1674 AAKELAENKKKIDALLDWVTSVGSSGG----QLLTNLPGMEQLSGASLEKGALDTTDGYM 1729
E+ + K+ ++ L V S Q L Q +E+ + +
Sbjct: 1280 CGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQE--- 1336
Query: 1730 GVNQAPEKLDKQCEMMKARH---QELLSQQQNF-----ILATQSAQAFL----DQHGH-- 1775
+A + + + E+ K R+ +E++S + F I T Q + D G+
Sbjct: 1337 ---EAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRA 1393
Query: 1776 ---NLTPEEQQMLQQ--KLGELKEQYSTSLAQSEAELKQ-----------VQTLQDELQK 1819
NLT E + + ++ +L Q + +L + E +++Q Q L+ EL++
Sbjct: 1394 QIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQ 1453
Query: 1820 FLQDHKE----FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFV 1875
Q E ++ L+ + K +++ +K E L L+ ++ + + + L+ V
Sbjct: 1454 VTQMRTEESVRYKQSLDDAAKTIQDKNK---EIERLKQLIDKETNDRKCLEDENARLQRV 1510
Query: 1876 TISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYH 1935
QK +E N KLK + T L R+ +
Sbjct: 1511 QYDLQKA---------NSSATETIN----KLKVQEQELTRLRIDYERVSQERTVKDQDIT 1557
Query: 1936 QFQNSADSLQAWMQACEANVEKL-------------LSDTVASDPGVLQEQLATTKQLQE 1982
+FQNS LQ Q E + +L L + + L+EQ L +
Sbjct: 1558 RFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQ 1617
Query: 1983 ELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQK 2042
+L + + ++ + R ++ + + QE + S ++L L + +++
Sbjct: 1618 QLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQ 1677
Query: 2043 AIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLK------QDIA 2096
A +++ Q+++E +S+ E +E +++ SL+ + +E L +L+ D+
Sbjct: 1678 AHLRNEHFQKAIEDKSRSLN--ESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLR 1735
Query: 2097 RQKSSLEATRE---MVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLL 2153
R +S ++ + + R + LQG + ++ + E L +QE E K+ L
Sbjct: 1736 RGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENL---RQEIEKFQKQAL 1792
Query: 2154 PQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEH 2213
+ + + Q ++ + +L +QD + ELN + +
Sbjct: 1793 EASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQR 1852
Query: 2214 LVTELSSCGFALD--LCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLV-- 2269
L E L+ Q+ + + +RK +E +K+ +E+ S + E +++
Sbjct: 1853 LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER 1912
Query: 2270 --RTFQKWLKETEGSIPPTETSMSAKELEK 2297
R + +ET+ + TE S +E++K
Sbjct: 1913 CRRKLEDSTRETQSQL-ETERSRYQREIDK 1941
Score = 70.1 bits (170), Expect = 6e-11
Identities = 282/1552 (18%), Positives = 599/1552 (38%), Gaps = 266/1552 (17%)
Query: 1948 MQACEANVEKLLSDTVASDPGVLQEQLATTKQLQE----ELAEHQVPVE----------- 1992
+Q+ + +K V PG Q Q TT ++ + H +E
Sbjct: 608 IQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETW 667
Query: 1993 ---KLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQS 2049
+LQK+ R I EG + T ++ Q S+ + + + L+ SQ+
Sbjct: 668 MLMELQKIRRQIEHCEG---------RMTLKNLPLADQGSSHHITVKINELKSVQNDSQA 718
Query: 2050 VQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMV 2109
+ E L L + + + + + G+ Q+ N + +SL R ++
Sbjct: 719 IAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYL----NSLCTVRALL 774
Query: 2110 TRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKES---SLKKLLPQAEMFEHLSGKL 2166
++T D V + +L E E +CL + E+ LKK+ + + L +
Sbjct: 775 QAILQTEDMLK--VYEARLTEE----ETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
Query: 2167 QQFMENKSRMLASGNQP----DQDITHFFQQIQELNLEMEDQQENLD----TLEHLVTEL 2218
+ ++ ++ + +Q D D+ F +++ +L + + +D LE + +L
Sbjct: 829 KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888
Query: 2219 SS--------CGFALDLCQHQDRVQ------------------NLRKDFTELQKTVKERE 2252
+ C + D + QD ++ NL + + + +E +
Sbjct: 889 RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
Query: 2253 KDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMS--------------AKELE-- 2296
K A C + ++ + ++ L ET +IP T + A+ +E
Sbjct: 949 KIAELCANSIKDYELQLASYTSGL-ETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
Query: 2297 -------KQIEHLKSLLDDWASKGTLVEEI-------------NC-KGTSLENLIMEITA 2335
+ + + L+D K T +E + NC K L+ + + A
Sbjct: 1008 TRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQA 1067
Query: 2336 PDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA 2395
SQ K ++G ++L + + ++N K +L + + + ++
Sbjct: 1068 ECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKS 1127
Query: 2396 ILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSP 2455
+ +R ++ + + + + + ++E L S + +K + + L++
Sbjct: 1128 VEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE----KAIKEKEYEIERLRVLLQEEGT 1183
Query: 2456 KIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQ------------- 2502
+ ++ + LA + Y N + + K + E+N E+++ ++
Sbjct: 1184 RKREYENELAKVRNHY-NEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRL 1242
Query: 2503 ----RQLEESASHL--ACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFM 2556
R L++ L + QA E + R E L G + + +KQ ++
Sbjct: 1243 SRENRDLKDEIVRLNDSILQATEQRRRA--EENALQQKACG------SEIMQKKQHLEIE 1294
Query: 2557 LKEFEARRQQ----HEQ-LNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNS 2611
LK+ +R + H+Q L EAA+ I ++ ++ Q+E + ++W E ++L+
Sbjct: 1295 LKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAK---RRW-EYENELSK 1350
Query: 2612 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 2671
+ D+ I+ E ++++ +T + Q+ E+TS R+
Sbjct: 1351 VRNNYDEEIISLKNQFETEINITK---------------TTIHQLTMQKEEDTSGYRA-- 1393
Query: 2672 EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALA 2731
Q+D+ +E ++L +E+ L E +R+E + + R +L+ L
Sbjct: 1394 -QIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELR 1452
Query: 2732 STQQ--------FQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQ 2783
Q ++Q D+ + DK + +ERL+ + + +K L
Sbjct: 1453 QVTQMRTEESVRYKQSLDDAAKTIQDKNKE----------IERLKQLIDKETNDRKCLED 1502
Query: 2784 HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQ-LVELKNHWEELSKKTADR-------QSR 2835
+ + + + + S K +Q Q L L+ +E +S++ + Q+
Sbjct: 1503 ENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNS 1562
Query: 2836 LKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRS 2895
LK+ + QK + + L + K +L L+ ++ +++ + K +
Sbjct: 1563 LKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMR--------RSLKEQAIKITN 1614
Query: 2896 LLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQE 2955
L + L A+ I+ SE D RD G + EEL+ + +E + ++L + QE
Sbjct: 1615 LTQQLEQAS-IVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQE 1673
Query: 2956 SFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQ----ALEPQVDYLR--- 3008
S K + E + +E D S S +E+L++ E L LE ++ LR
Sbjct: 1674 SVKQAHLRNEHFQKAIE--DKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEY 1731
Query: 3009 -NFTQGLVE-DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV 3066
+ +G E D+ + +L Q +++ LE++ +N EN + I +F +
Sbjct: 1732 DDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQA 1791
Query: 3067 REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLE 3126
E +++ + ++ + ++ +SL +I+ L +K + +L+ E + A + LE
Sbjct: 1792 LEASNRIQESKNQCT---QVVQERESLLVKIK--VLEQDKARLQRLEDELNRA--KSTLE 1844
Query: 3127 EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAE 3186
E +K+ LE +Q + K + + E + ++E + K + +
Sbjct: 1845 AE-----TRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIES--EREKSEREKNSLRS 1897
Query: 3187 EAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQ-QVNGLGQ---GLIQSAGKDC 3242
E E LQ + E ++L D + Q++ + + Q +++ L Q G + +C
Sbjct: 1898 EIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTEC 1957
Query: 3243 DVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIAN 3302
E ++ ++ L KKV QL E L + L+ LL EE+ +
Sbjct: 1958 -----EWTVDTSKLVFDGLRKKVT--AMQLYECQL---IDKTTLDKLLKGKKSVEEVASE 2007
Query: 3303 QKP--------------PSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAE 3340
+P P +Y +V+A+ ++ L ++TV +L+A+
Sbjct: 2008 IQPFLRGAGSIAGASASPKEKYSLVEAK-------RKKLISPESTVMLLEAQ 2052
Score = 63.5 bits (153), Expect = 5e-09
Identities = 239/1268 (18%), Positives = 497/1268 (39%), Gaps = 187/1268 (14%)
Query: 3241 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3300
D D+ + ++ RW ++K++ R+ L++ + ++D + WL D +
Sbjct: 850 DLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQ 909
Query: 3301 AN-QKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQ 3359
+ + + V + EQK L + ++ + +Q A S + D E Q
Sbjct: 910 DSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANS--IKDYEL---Q 964
Query: 3360 LESLESRWTELLS---KAAARQKQLEDILVLAKQFH----ETAEPISDFLSVTEKKLANS 3412
L S S LL+ K Q IL A H E D+ + L +
Sbjct: 965 LASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSL 1024
Query: 3413 EPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSL 3472
E + + KI+ LEE++ ++ + +S + + L + +
Sbjct: 1025 EDLKLKNTKIE-------VLEEEL-----------RLARDANS-ENCNKNKFLDQNLQKY 1065
Query: 3473 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLN----WLAEVEDKLSSVFVKDFKQ 3528
QA S+ + K A L++ A L G+ + L+ + E+ +K++ + + +
Sbjct: 1066 QAECSQFK----AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL-TYEIED 1120
Query: 3529 DVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADI 3588
+ R+ E+ +++KN ++ + K+ G + L E IK + +I
Sbjct: 1121 EKRRRKSV------EDRFDQQKNDYDQLQKARQCEKENLGWQKL---ESEKAIKEKEYEI 1171
Query: 3589 TVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQK 3648
+ LR L Q + T+ + EL EE++ + T I + ++
Sbjct: 1172 -----ERLRVLLQ--EEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEI 1224
Query: 3649 ELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEI 3708
++KE L R LD+L + + + + D I + D I
Sbjct: 1225 SMQKEDDSKNL--------------------RNQLDRL----SRENRDLKDEIVRLNDSI 1260
Query: 3709 DAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKD 3768
A ++ ++ E+ A + A +E +K L I L+ QV + S D RHK
Sbjct: 1261 LQATEQRRRAEENALQQKACGSEIMQKKQHL-EIELK--------QVMQQRSEDNARHKQ 1311
Query: 3769 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 3828
S++E ++ +E + + E E +++E + L+ R E L NQF
Sbjct: 1312 SLEE----AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQF- 1366
Query: 3829 ETYEELSPWIEETRALIAQLP-SPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 3887
ET I T+ I QL D R Q + + + S++E + L
Sbjct: 1367 ETE------INITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTL---- 1416
Query: 3888 QLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQST-QITEFHDKIEPML 3946
E VEE Q+ + +++ + +Q + L + T + + ++
Sbjct: 1417 ---TQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAA 1473
Query: 3947 ETLENLSSRL-RMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4005
+T+++ + + R+ LI E + R+C+ D + L+++Q + E I + +
Sbjct: 1474 KTIQDKNKEIERLKQLIDKETND-RKCLEDENA---RLQRVQYDLQKANSSATETINKLK 1529
Query: 4006 GADKDL---------AAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMA 4056
+++L ++E K + F +K +++ ++ L D
Sbjct: 1530 VQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSC 1589
Query: 4057 ALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEET-DGLHEELEFIRILGADLIF 4115
++ + + L+ I + + QQ+E A +K+ + D L ++ + +L L
Sbjct: 1590 KRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD---VLDGHL-- 1644
Query: 4116 ACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV 4175
EK ++ + +++ E L + + E ++ A +Q ++ L+ +
Sbjct: 1645 ----REKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESK 1700
Query: 4176 IKLCTMPPVGTDLN----TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATD-ET 4230
I++ + + +L ++++L ++ ++ + + E + + L L+
Sbjct: 1701 IEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISN 1760
Query: 4231 DRDIIREPL-TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLD 4289
+R + + L +L+ ENL ++I Q + AL A + Q + + + E LL
Sbjct: 1761 NRTLELQGLINDLQRERENLRQEIEKFQKQ---ALEASNRIQESKNQCTQVVQERESLL- 1816
Query: 4290 AQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLE 4349
KV+E + A+ L++++ ++T+E + + LE + L
Sbjct: 1817 ------VKIKVLEQDKARLQRLEDELNRAKSTLEAETRV-KQRLECEKQQIQNDLNQ--- 1866
Query: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQ----GFHSEIEDFLLELTRMESQLSASKPTGG 4405
W++ + EE ++++S ++++ SEIE E+ R+E
Sbjct: 1867 -----WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE----------- 1910
Query: 4406 LPETAREQL-DTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQK 4464
E R +L D+ E SQL+ + Y + +DK L + GS +T+ E +
Sbjct: 1911 --ERCRRKLEDSTRETQSQLETERSRYQREIDK-----LRQRPYGSHRETQ-----TECE 1958
Query: 4465 WHVVSSKM 4472
W V +SK+
Sbjct: 1959 WTVDTSKL 1966
Score = 62.0 bits (149), Expect = 2e-08
Identities = 216/1149 (18%), Positives = 454/1149 (39%), Gaps = 172/1149 (14%)
Query: 3794 EKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAI 3853
EK L +++ I R LE+ + + + Y+ W+ + + L S
Sbjct: 858 EKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917
Query: 3854 -DHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAEN--M 3910
D + + E + L I+ + +++ KI +L + ++ E+ Y +
Sbjct: 918 GDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIA-ELCANSIKDYELQLASYTSGLETLL 976
Query: 3911 YAQIKEEVRQR--ALALDEA-------VSQSTQITEFHDKIEPMLETLENLSSRLRMPPL 3961
IK + Q + L EA + T+ +++ + ML++LE+L + +
Sbjct: 977 NIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEV 1036
Query: 3962 IPAEVDKIRECISDN----KSATVELEKLQP----------SFEALKRRGEELIGRS--Q 4005
+ E+ R+ S+N K L+K Q S E LKR+ E L G+S Q
Sbjct: 1037 LEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAE-LDGKSAKQ 1095
Query: 4006 GADKDLAA-KEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4064
DK KE+ +K+ ++ + ED K R + E +F +K YD +
Sbjct: 1096 NLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQ-----QKNDYDQLQKARQCEK 1150
Query: 4065 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4124
++ Q++E+ + IKE+ E+E +R+L + E E E
Sbjct: 1151 E--------------NLGWQKLESEKAIKEK----EYEIERLRVLLQEEGTRKREYEN-E 1191
Query: 4125 VRKSIDEMNNAWENLNKTWKERLEKLEDAM-QAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4183
+ K + N NL ++ + + + + ++Q +D + + + LD
Sbjct: 1192 LAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDR---------- 1241
Query: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQ-----GELMLKKATDETDRDIIREP 4238
+ + +KD++ + + ++ +Q+ E+ Q E+M KK E
Sbjct: 1242 LSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEI-------- 1293
Query: 4239 LTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDP 4298
ELK + + E A + LE A + +E L + E +A+R
Sbjct: 1294 --ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKA-----EFQEEAKRRWE--- 1343
Query: 4299 KVIEVELAK-HHVLKNDVLAHQATVET---VNKAGNELLESSAGDDASSLRSRLEAMNQC 4354
E EL+K + ++++ + ET + K L +D S R++++ + +
Sbjct: 1344 --YENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRE 1401
Query: 4355 WESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQL 4414
S+ E ++L++TL Q L R+E + K TG ++QL
Sbjct: 1402 NRSL----SEEIKRLKNTLTQTTE----------NLRRVEEDIQQQKATGSEVSQRKQQL 1447
Query: 4415 DTHMELYSQLKAKEET-YNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4473
+ + +Q++ +E Y Q LD + ++ + E+ L++++ + +E
Sbjct: 1448 EVELRQVTQMRTEESVRYKQSLDDAAKTIQDKN-----KEIERLKQLIDKETN-DRKCLE 1501
Query: 4474 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSL-NIASPPSLILNTVLSQIEEHKVFAN 4532
+ ++L+ + +S E IN L + EQ L + + + ++ F N
Sbjct: 1502 DENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQN 1561
Query: 4533 EVNAHRDQIIELDQTGNQLKFLSQKQDVV-------------LIKNLLVSVQSRWEKVVQ 4579
+ + Q ++++ N+LK + + +K + + + +++ Q
Sbjct: 1562 SLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQ 1621
Query: 4580 RSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE-----ISNDPDKIKLQLS 4634
SI + RS DD R++ + + + ++ L SE+E + + + +K
Sbjct: 1622 ASIVKKRSEDDLRQQ-RDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL 1680
Query: 4635 KHKEFQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTV-CGKSV 4692
+++ FQK + K + + ++ I R L ++ L+ L +R ++D + G+S
Sbjct: 1681 RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE 1740
Query: 4693 ERQHK------LEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAH 4746
K L L S LQ L++ L + NL
Sbjct: 1741 ADSDKNATILELRSQLQISNNRTLELQGLINDLQRERE----------------NLRQEI 1784
Query: 4747 KVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV------KGQLQELSTRWDTVCKLSV 4800
+ FQK+ + + +Q K ++++ + K +LQ L + K ++
Sbjct: 1785 EKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNR-AKSTL 1843
Query: 4801 SKQSRLEQALK-QAEVFRDTVHMLLEWLSEAEQTLR----FRGALPDDTEALQSLIDTHK 4855
++R++Q L+ + + ++ ++ S E+ +R R + +L+S I+ +
Sbjct: 1844 EAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQ 1903
Query: 4856 EFMKKVEEK 4864
+K++EE+
Sbjct: 1904 AEIKRIEER 1912
Score = 49.3 bits (116), Expect = 1e-04
Identities = 201/1157 (17%), Positives = 455/1157 (39%), Gaps = 181/1157 (15%)
Query: 4307 KHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEERE 4366
K+ L+N+V +E +N + L S ++R+ L+A+ Q E +L+ E R
Sbjct: 738 KYCYLQNEVFGLFQKLENINGVTDGYLNSLC-----TVRALLQAILQT-EDMLKVYEARL 791
Query: 4367 QQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKA 4426
+ ++ ++E + L ++++ L+ K L T + +L +++SQ
Sbjct: 792 TEEETVCLDLD----KVEAYRCGLKKIKNDLNLKK---SLLATMKTELQKAQQIHSQTSQ 844
Query: 4427 KEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLA 4486
+ Y+ LD G+ G K Q L +W + +++ R LE+ +
Sbjct: 845 QYPLYD--LDLGKF----------GEKVTQ----LTDRWQRIDKQIDFRLWDLEKQIKQL 888
Query: 4487 TEFQNSLQEFINWLTLAEQSL-NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELD 4545
++++ Q F WL A++ ++ S NTV+ + E K +E++ RD+ E+
Sbjct: 889 RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
Query: 4546 QTGN---------QLKFLSQKQDVVLIKNLLVS---VQSRWEKVVQRSIERGRSLDDARK 4593
+ +L+ S + + N+ + +QS ++Q + + +
Sbjct: 949 KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
Query: 4594 RAKQFHEAWKKLIDWLEDAE------SHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQ 4647
R+ ++ +++ LED + L+ EL ++ D + +K+K + L Q
Sbjct: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDAN--SENCNKNKFLDQNLQKYQ 1066
Query: 4648 ---PVYDTTIRTGRALKEKTLLPEDS--QKLDNFLGEVRDKWDTVCGKSVE------RQH 4696
+ + + LK + L S Q LD G++++ + + + E R+
Sbjct: 1067 AECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRK 1126
Query: 4697 KLEEALLFSGQFMDALQAL-------VDWLYKVEPQLAEDQPVHGDLDLVMNLMD---AH 4746
+E+ D LQ + W K+E + A + + L + L +
Sbjct: 1127 SVEDRFDQQKNDYDQLQKARQCEKENLGW-QKLESEKAIKEKEYEIERLRVLLQEEGTRK 1185
Query: 4747 KVFQKELGKRTG---------------TVQVLKRSGRELIENSRDDTTWVKGQLQELSTR 4791
+ ++ EL K + + K + +E+ DD+ ++ QL LS
Sbjct: 1186 REYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRE 1245
Query: 4792 -----------WDTVCKLSVSKQSRLEQALKQ----AEVFRDTVHMLLE----WLSEAEQ 4832
D++ + + ++ E AL+Q +E+ + H+ +E +E
Sbjct: 1246 NRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSED 1305
Query: 4833 TLRFRGALPDDTEALQSL---IDTHKEFMKKVEEKRVDVNSAVA-----MGEVILAVCHP 4884
R + +L + + +Q I+ K ++ ++R + + ++ E I+++ +
Sbjct: 1306 NARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQ 1365
Query: 4885 -----DCITTIKHWITI--------IRARFEEVLTWAK---QHQQRLETALSELVANAEL 4928
+ T H +T+ RA+ + + + + +RL+ L++ N
Sbjct: 1366 FETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRR 1425
Query: 4929 LEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKR 4988
+EE + + + + QR Q+ + + +V Q EE R + +D KT +
Sbjct: 1426 VEEDIQQQKATGSEVSQRKQQ-LEVELRQVT------QMRTEESVRYKQSLDDAAKTIQD 1478
Query: 4989 KNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKN----PRINQLSARWQQVWLL 5044
KN E + + RK L + + N IN+L + Q++ L
Sbjct: 1479 KNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRL 1538
Query: 5045 ALERQRKLNDALDRLEELKEFANF--DFDVWRKKYMRWMNH-KKSRVMDFFRRIDKDQDG 5101
++ +R + + +++ F N + + ++K +N K++ D +R +++
Sbjct: 1539 RIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEEL 1598
Query: 5102 KITRQEFIDGILASKFPTTKLEMTAVADIFDRDG--------DGYIDYYEFVAALHPNKD 5153
+ R+ + + T +LE ++ D DG++ + ++
Sbjct: 1599 EGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQ-----RTQEE 1653
Query: 5154 AYRPTTDADKIEDEVTRQVAQCKCA--KRFQVEQIGENKYRFGDSQQLRLVRILRSTVMV 5211
R +++ + + ++ ++ K A + ++ E+K R + ++ + R+ ++
Sbjct: 1654 LRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERL--QSLTE 1711
Query: 5212 RVGGGWMALDEFL----VKNDPCRARGR---------TNIELREKFILPEGAS---QGMT 5255
+ + L+E L ++ D R RGR T +ELR + + + QG+
Sbjct: 1712 NLTKEHLMLEEELRNLRLEYDDLR-RGRSEADSDKNATILELRSQLQISNNRTLELQGLI 1770
Query: 5256 PFRSRGR---RSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLK 5312
R R R + +S+ +S + CT + + KV+ ++L+
Sbjct: 1771 NDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQ 1830
Query: 5313 RPTPTFHSSRTSLAGDT 5329
R + ++++L +T
Sbjct: 1831 RLEDELNRAKSTLEAET 1847
Score = 42.7 bits (99), Expect = 0.010
Identities = 170/883 (19%), Positives = 316/883 (35%), Gaps = 175/883 (19%)
Query: 4171 LDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDET 4230
LD C + + DLN K L MK E+ + Q + + Q L +
Sbjct: 801 LDKVEAYRCGLKKIKNDLNLKKSLLATMK---TELQKAQQIHSQTSQQYPLY------DL 851
Query: 4231 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA 4290
D E +T+L W+ + ++I R LE + L ++ + WL + D+
Sbjct: 852 DLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDS 911
Query: 4291 QRPIS-GDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLE 4349
+ GD + L + L +++ + E V K EL +S D L S
Sbjct: 912 LESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIA-ELCANSIKDYELQLASYTS 970
Query: 4350 AMNQCWESVLQKTEEREQQLQS----TLQQAQGFHSEIEDFLL---ELTRMESQLSASKP 4402
+ +++T +QS LQ+A H+ + L + R S++ S
Sbjct: 971 GLETLLNIPIKRT-----MIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLE 1025
Query: 4403 TGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLE 4462
L T E L+ + L ++ N+ LD+
Sbjct: 1026 DLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNL----------------------- 1062
Query: 4463 QKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLS 4522
QK+ S+ + + + LEE A S A+Q+L+ LN ++
Sbjct: 1063 QKYQAECSQFKAKLASLEELKRQAELDGKS----------AKQNLDKCYGQIKELNEKIT 1112
Query: 4523 QIEEHKVFANEVNAHRDQIIE--LDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQR 4580
++ + E R + +E DQ N L QK +NL W+K+
Sbjct: 1113 RL----TYEIEDEKRRRKSVEDRFDQQKNDYDQL-QKARQCEKENL------GWQKLESE 1161
Query: 4581 SIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQ 4640
+ + + R R E +K E N+ K++ +
Sbjct: 1162 KAIKEKEYEIERLRVLLQEEGTRK---------------REYENELAKVR------NHYN 1200
Query: 4641 KTLGGKQPVYDTTIR-TGRALKEKTLLPEDSQK-----LDNFLGEVRDKWDTVCG----- 4689
+ + + Y+T I T +KE ++ ED K LD E RD D +
Sbjct: 1201 EEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSI 1260
Query: 4690 -KSVERQHKLEEALL----FSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMD 4744
++ E++ + EE L + M Q L L +V Q +ED H +L +
Sbjct: 1261 LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARH-----KQSLEE 1315
Query: 4745 AHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQS 4804
A K Q + ++ LK +E E RW+ +LS + +
Sbjct: 1316 AAKTIQ----DKNKEIERLKAEFQE-----------------EAKRRWEYENELSKVRNN 1354
Query: 4805 RLEQALK-------QAEVFRDTVHMLLEWLSEAEQTLRFRG----------ALPDDTEAL 4847
E+ + + + + T+H L + + E T +R +L ++ + L
Sbjct: 1355 YDEEIISLKNQFETEINITKTTIHQLT--MQKEEDTSGYRAQIDNLTRENRSLSEEIKRL 1412
Query: 4848 QSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIR----ARFEE 4903
++ + E +++VEE D+ A G + + +T +R R+++
Sbjct: 1413 KNTLTQTTENLRRVEE---DIQQQKATGSEVSQ--RKQQLEVELRQVTQMRTEESVRYKQ 1467
Query: 4904 VLTWA-------KQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNID 4956
L A + +RL+ + + + + LE+ A +Q + L Q+ + I+
Sbjct: 1468 SLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDL-QKANSSATETIN 1526
Query: 4957 RVKA-------LIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIE 4992
++K L +++ +E T K D+ R + K ++
Sbjct: 1527 KLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQ 1569
Score = 39.7 bits (91), Expect = 0.082
Identities = 28/68 (41%), Positives = 36/68 (52%), Gaps = 4/68 (5%)
Query: 5330 SNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDT 5389
S SS + + A +S SR GSR+GSR+GSR+ SRRGS FD S
Sbjct: 2807 SVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGS----FDATGNSSYSYSY 2862
Query: 5390 SESSAAGG 5397
S SS++ G
Sbjct: 2863 SFSSSSIG 2870
>gi|58530842 desmoplakin isoform II [Homo sapiens]
Length = 2272
Score = 516 bits (1328), Expect = e-145
Identities = 365/1351 (27%), Positives = 673/1351 (49%), Gaps = 120/1351 (8%)
Query: 579 SSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKE 638
S DE E L W+ + + +++ WG DL SVE + + + IH S+ +
Sbjct: 178 SGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDY------ 231
Query: 639 ARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNE 698
R K+ + A + +LE +Y L + S RM HL+ L + + E++W+N+
Sbjct: 232 -RWQLDKIKADLREKSA--IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIND 288
Query: 699 KEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVE 758
EEEEL YDWSD N+NI+ K+ FS +LE K+ L+ ++ L L HPA +E
Sbjct: 289 CEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIE 348
Query: 759 AYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHN 818
AY +Q+Q W+ Q+ C++ H+KEN AYFQFF +A+ E++L+ LQDSI++KY CD N
Sbjct: 349 AYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKN 408
Query: 819 TSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCD 878
L L + +++ E+E++++ K V +LV +SK IVQLKPR+PD+ I ++A+CD
Sbjct: 409 MPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCD 468
Query: 879 YRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQ 938
Y+Q + + K DEC+L+DN++R+KW V P G + +VPSV +IPPPN A++++ ++EQ
Sbjct: 469 YKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQ 528
Query: 939 SYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYE 998
Y+ ++ALW+QL++N KSL+SW+Y D++ ++ + KL++ + + + +L+ HY+
Sbjct: 529 YYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQ 588
Query: 999 DFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYIS------- 1051
+F+++S+ S +F D+ +++ + + +Q L+ + + +TV I+
Sbjct: 589 EFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQD 648
Query: 1052 ----------------------ELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNAL 1089
EL+ IR ++E E R+ + LA D+ + +
Sbjct: 649 VNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLA----DQGSSHHITV 704
Query: 1090 RIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLS 1149
+I E + Q D Q + L+ + +F S L++E+ L +K++++ G++
Sbjct: 705 KINELKSVQNDSQAIAEVLNQLKDMLANFR----GSEKYCYLQNEVFGLFQKLENINGVT 760
Query: 1150 TVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKD 1209
YLN L TV ++++I E ++K YE +L++EE V DL +EA+ L+ +D+
Sbjct: 761 DGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNL 820
Query: 1210 KNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSE 1269
K S+ + + E+ KA+ + Q S+ P +LDL ++ EK +QL +RW R+ Q++ R +
Sbjct: 821 KKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWD 880
Query: 1270 LESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERN 1329
LE + L +YR + KW+ + +Q+ ++ + DS + L++Q L +EI
Sbjct: 881 LEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGK 940
Query: 1330 QTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLR 1389
+ K ++ QK ++ + +KDYELQL +Y + +E+ P KR + S S I QE D+
Sbjct: 941 RDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVH 1000
Query: 1390 TRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKA 1449
RY L+T + + +++S+ L+ LE+ + K +E ++E L LAR+ A
Sbjct: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKL-----KNTKIEVLEEEL----RLARD----A 1047
Query: 1450 TSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI--FLAKHGHKLSEKEKKQI 1507
S ++ +++ + + Q + K + E + +++ AK + K++
Sbjct: 1048 NSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKEL 1107
Query: 1508 SEQLNAL----------NKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE 1557
+E++ L K+ D D N QLQ A Q E++ L Q+ + ++
Sbjct: 1108 NEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQK--ARQCEKENLGWQKLESEKAIK 1165
Query: 1558 DLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFM 1617
+ + + L Q++ + ++ +++L + IQ VV++ E +
Sbjct: 1166 EKEYEIERLRVLL--------QEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLL 1217
Query: 1618 EENQT-KLSPRELTALREKLHQAKEQYEALQEETRVAQK------ELEEAVTSALQQETE 1670
+ + + L L ++L++AK EA ETRV Q+ +++ + Q +
Sbjct: 1218 VKIKVLEQDKARLQRLEDELNRAKSTLEA---ETRVKQRLECEKQQIQNDLNQWKTQYSR 1274
Query: 1671 KSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMG 1730
K +A +++ ++K + + S+ S +L + +E+ LE +T
Sbjct: 1275 KEEAIRKIESEREKSEREKN---SLRSEIERLQAEIKRIEERCRRKLEDSTRETQS---- 1327
Query: 1731 VNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLG 1790
E+ Q E+ K R + S ++ + +D +++ +L
Sbjct: 1328 -QLETERSRYQREIDKLRQRPYGSHRE----TQTECEWTVDTSKLVFDGLRKKVTAMQLY 1382
Query: 1791 ELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ----------DHKEFESWLERSEKELEN 1840
E + T+L + K V+ + E+Q FL+ KE S +E K+L
Sbjct: 1383 ECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKL-- 1440
Query: 1841 MHKGGSSPETLPSLLKRQGSFSEDVISHKGD 1871
SPE+ LL+ Q + + H+ +
Sbjct: 1441 -----ISPESTVMLLEAQAATGGIIDPHRNE 1466
Score = 53.9 bits (128), Expect = 4e-06
Identities = 186/967 (19%), Positives = 376/967 (38%), Gaps = 155/967 (16%)
Query: 1807 LKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDV- 1865
L+Q++ L+ E +K L+ ++ ++ + +S+K ++ + P +L+ + +D
Sbjct: 415 LEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQK 474
Query: 1866 ISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK-LKDATERYTALHSKCTRLG 1924
I HKGD + + ++ + G P + LV L A+ C ++
Sbjct: 475 IVHKGDECILKDNNER----SKWYVTG--PGGVDMLVPSVGLIIPPPNPLAVDLSC-KIE 527
Query: 1925 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 1984
+ +L ++Q + SL +W C ++EK+ + T+A + QE T +
Sbjct: 528 QYYEAILALWNQLYINMKSLVSW-HYCMIDIEKIRAMTIAKLKTMRQEDYMKT------I 580
Query: 1985 AEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA---ERSSLLQ 2041
A+ ++ Q+ R+ E D R +Q H+Q+L L + ++
Sbjct: 581 ADLEL---HYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTT 637
Query: 2042 KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQ-EALATNMKLKQ-DIARQK 2099
I + Q+ + + E + L Q E M LK +A Q
Sbjct: 638 TEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQG 697
Query: 2100 SSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRF---EQLCLQQQEKESSLKKLLPQA 2156
SS T ++ DS A + +L ++ F E+ C Q E +KL
Sbjct: 698 SSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKL---- 753
Query: 2157 EMFEHLSGKLQQFMENKS--RMLASGNQPDQDITHFFQ--------------QIQELNLE 2200
E+++G ++ + R L +D+ ++ +++
Sbjct: 754 ---ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCG 810
Query: 2201 MEDQQENLDTLEHLV----TELSSCG------------FALDLCQHQDRVQNLRKDFTEL 2244
++ + +L+ + L+ TEL + LDL + ++V L + +
Sbjct: 811 LKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRI 870
Query: 2245 QKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM--SAKELEKQIEHL 2302
K + R D +QL +R + F KWL + + E+ + + + +
Sbjct: 871 DKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQ 930
Query: 2303 KSLLDDWASKGTLVEEIN-----CKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVN 2357
K+L + + K EE+ C S+++ +++ + S +T +P + + S +
Sbjct: 931 KNLHSEISGKRDKSEEVQKIAELC-ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPS 989
Query: 2358 GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2417
G I + +DV+ +Y +L + L +L +E++ K N+ ++ LE
Sbjct: 990 GV--------ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDL-KLKNTKIEVLE-- 1038
Query: 2418 EEVLKSMDAMSS--------PTKTETVKAQAESNKAFLAELE--------------QNSP 2455
EE+ + DA S + +A+ KA LA LE QN
Sbjct: 1039 EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLD 1098
Query: 2456 K----IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 2511
K I+++ E + L TY E K +++ + + ++ ARQ + E
Sbjct: 1099 KCYGQIKELNEKITRL--TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLG-- 1154
Query: 2512 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLN 2571
+Q ES+ + EKE + ++++ +L+E R++++E N
Sbjct: 1155 ---WQKLESEKA--IKEKEYEI-----------------ERLRVLLQEEGTRKREYE--N 1190
Query: 2572 EAAQGILTGPGDVSLSTSQVQ---------KELQSINQKWVELTDKLNSRSSQID-QAIV 2621
E A+ + T VQ K L+ + L D+LN S ++ + V
Sbjct: 1191 ELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRV 1250
Query: 2622 KST---QYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 2678
K + Q++ DL++ ++ I ++ E ++ E + +RS++E+L E+
Sbjct: 1251 KQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSER---EKNSLRSEIERLQAEI 1307
Query: 2679 KEAQTLC 2685
K + C
Sbjct: 1308 KRIEERC 1314
Score = 48.1 bits (113), Expect = 2e-04
Identities = 136/744 (18%), Positives = 278/744 (37%), Gaps = 124/744 (16%)
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEES 2508
EL+ Q + E L L N + +E + +Q E+ +++ + L
Sbjct: 708 ELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
Query: 2509 ASHLACFQA---AESQLRPW---LMEKELMMGVLGP-------LSIDPNMLNAQKQQVQF 2555
+ A QA E L+ + L E+E + L L N LN +K +
Sbjct: 768 CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
Query: 2556 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 2615
M E + +Q H Q ++ L + +++ + +W + +++ R
Sbjct: 828 MKTELQKAQQIHSQTSQQYPLY-------DLDLGKFGEKVTQLTDRWQRIDKQIDFRLWD 880
Query: 2616 IDQAIVKSTQYQELLQDLSEKVRAVGQRL-SVQSAISTQPEAVKQQLEETSEIRSDLEQL 2674
+++ I + Y++ Q + + +R S++S V + L E + S++
Sbjct: 881 LEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGK 940
Query: 2675 DHEVKEAQTLCDELSVLIGEQYLK-DELKKRLET----------VALPLQGLEDLAADRI 2723
+ +E Q + + + I + L+ LET + P + AAD
Sbjct: 941 RDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVH 1000
Query: 2724 NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQ 2783
R L + + + E+ L+D + + K + +L + EN K L+Q
Sbjct: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
Query: 2784 HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA 2843
+ Y+ ++ ++ L S L ELK EL K+A +
Sbjct: 1061 NLQKYQAECSQFKAKLAS-------------LEELKRQ-AELDGKSAKQN---------- 1096
Query: 2844 QKYQWHVEDLVPWIEDCKAKMSEL--RVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILN 2901
++ C ++ EL ++T ++E R K++ + +++++ + L
Sbjct: 1097 -------------LDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQ 1143
Query: 2902 SAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIE 2961
A + +++ + +K + + E++ L+E R RE++
Sbjct: 1144 KAR-------QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKAS 1196
Query: 2962 KKVEGAKHQL-EIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD 3020
+++ +K+Q ++ S K LE+ +A+ LQ LE +
Sbjct: 1197 NRIQESKNQCTQVVQERESLLVKIKVLEQDKAR---LQRLEDE----------------- 1236
Query: 3021 GSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDEL 3080
L++A+ + VKQR+ ++N L + R E ++ ++
Sbjct: 1237 -------LNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKS 1289
Query: 3081 DGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKREL 3140
+ R+ +SL+S+IE L+ +I+ E CR LE+ L+ E
Sbjct: 1290 E------REKNSLRSEIER----------LQAEIKRIEERCRRKLEDSTRETQSQLETER 1333
Query: 3141 EALNKQCGKLTER--GKARQEQLE 3162
++ KL +R G R+ Q E
Sbjct: 1334 SRYQREIDKLRQRPYGSHRETQTE 1357
Score = 48.1 bits (113), Expect = 2e-04
Identities = 113/609 (18%), Positives = 251/609 (41%), Gaps = 84/609 (13%)
Query: 4307 KHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEERE 4366
K+ L+N+V +E +N + L S ++R+ L+A+ Q E +L+ E R
Sbjct: 738 KYCYLQNEVFGLFQKLENINGVTDGYLNSLC-----TVRALLQAILQT-EDMLKVYEARL 791
Query: 4367 QQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKA 4426
+ ++ ++E + L ++++ L+ K L T + +L +++SQ
Sbjct: 792 TEEETVCLDLD----KVEAYRCGLKKIKNDLNLKK---SLLATMKTELQKAQQIHSQTSQ 844
Query: 4427 KEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLA 4486
+ Y+ LD G+ G K Q L +W + +++ R LE+ +
Sbjct: 845 QYPLYD--LDLGKF----------GEKVTQ----LTDRWQRIDKQIDFRLWDLEKQIKQL 888
Query: 4487 TEFQNSLQEFINWLTLAEQSL-NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELD 4545
++++ Q F WL A++ ++ S NTV+ + E K +E++ RD+ E+
Sbjct: 889 RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
Query: 4546 QTGN---------QLKFLSQKQDVVLIKNLLVS---VQSRWEKVVQRSIERGRSLDDARK 4593
+ +L+ S + + N+ + +QS ++Q + + +
Sbjct: 949 KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
Query: 4594 RAKQFHEAWKKLIDWLEDAE------SHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQ 4647
R+ ++ +++ LED + L+ EL ++ D + +K+K + L Q
Sbjct: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDAN--SENCNKNKFLDQNLQKYQ 1066
Query: 4648 ---PVYDTTIRTGRALKEKTLLPEDS--QKLDNFLGEVRDKWDTVCGKSVE------RQH 4696
+ + + LK + L S Q LD G++++ + + + E R+
Sbjct: 1067 AECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRK 1126
Query: 4697 KLEEALLFSGQFMDALQAL-------VDWLYKVEPQLAEDQPVHGDLDLVMNLMD---AH 4746
+E+ D LQ + W K+E + A + + L + L +
Sbjct: 1127 SVEDRFDQQKNDYDQLQKARQCEKENLGW-QKLESEKAIKEKEYEIERLRVLLQEEGTRK 1185
Query: 4747 KVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV------KGQLQELSTRWDTVCKLSV 4800
+ ++ EL K + +Q K ++++ + K +LQ L + K ++
Sbjct: 1186 REYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNR-AKSTL 1244
Query: 4801 SKQSRLEQALK-QAEVFRDTVHMLLEWLSEAEQTLR----FRGALPDDTEALQSLIDTHK 4855
++R++Q L+ + + ++ ++ S E+ +R R + +L+S I+ +
Sbjct: 1245 EAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQ 1304
Query: 4856 EFMKKVEEK 4864
+K++EE+
Sbjct: 1305 AEIKRIEER 1313
Score = 47.0 bits (110), Expect = 5e-04
Identities = 106/513 (20%), Positives = 197/513 (38%), Gaps = 81/513 (15%)
Query: 4171 LDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDET 4230
LD C + + DLN K L MK E+ + Q + + Q L +
Sbjct: 801 LDKVEAYRCGLKKIKNDLNLKKSLLATMK---TELQKAQQIHSQTSQQYPLY------DL 851
Query: 4231 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA 4290
D E +T+L W+ + ++I R LE + L ++ + WL + D+
Sbjct: 852 DLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDS 911
Query: 4291 QRPIS-GDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLE 4349
+ GD + L + L +++ + E V K EL +S D L S
Sbjct: 912 LESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIA-ELCANSIKDYELQLASYTS 970
Query: 4350 AMNQCWESVLQKTEEREQQLQS----TLQQAQGFHS---------------------EIE 4384
+ +++T +QS LQ+A H+ +E
Sbjct: 971 GLETLLNIPIKRT-----MIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLE 1025
Query: 4385 DFLLELTR---MESQLSASKPTGGLPETAREQLDTHMELY----SQLKAKEETYNQLLDK 4437
D L+ T+ +E +L ++ + LD +++ Y SQ KAK + +L K
Sbjct: 1026 DLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEEL--K 1083
Query: 4438 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK-------SKLEEALNLATEFQ 4490
+ L + + K + L +K ++ ++E+ K + ++ N + Q
Sbjct: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQ 1143
Query: 4491 NSLQ---EFINWLTLAEQSLNIASPPSLILNTVLSQIE--EHKVFANEVNAHRDQIIELD 4545
+ Q E + W L + + VL Q E + + NE+ ++I
Sbjct: 1144 KARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI---Q 1200
Query: 4546 QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKL 4605
++ NQ + Q+++ +L+K KV+++ R + L+D RAK EA ++
Sbjct: 1201 ESKNQCTQVVQERESLLVK----------IKVLEQDKARLQRLEDELNRAKSTLEAETRV 1250
Query: 4606 IDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 4638
LE + +I ND ++ K Q S+ +E
Sbjct: 1251 KQRLECEKQ------QIQNDLNQWKTQYSRKEE 1277
Score = 47.0 bits (110), Expect = 5e-04
Identities = 116/579 (20%), Positives = 238/579 (41%), Gaps = 51/579 (8%)
Query: 4127 KSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG- 4185
+ + ++ + W+ ++K RL LE ++ Y+D QA WL + + ++ +
Sbjct: 858 EKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917
Query: 4186 TDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHL 4245
D NTV LNE K E+ ++ + E++ EL A D ++ T
Sbjct: 918 GDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC---ANSIKDYELQLASYTSGLET 974
Query: 4246 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVEL 4305
N+ K Q G +L HA + LT + + + + ++++
Sbjct: 975 LLNIPIKRTMIQSP-SGVILQEAADVHA--RYIELLTRSGDYYRFLSEMLKSLEDLKLKN 1031
Query: 4306 AKHHVLKNDV-LAHQATVETVNKAGNELLESSAGD---DASSLRSRLEAMNQC------- 4354
K VL+ ++ LA A E NK N+ L+ + + S +++L ++ +
Sbjct: 1032 TKIEVLEEELRLARDANSENCNK--NKFLDQNLQKYQAECSQFKAKLASLEELKRQAELD 1089
Query: 4355 WESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQL 4414
+S Q ++ Q++ ++ EIED +E + K + AR+
Sbjct: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCE 1149
Query: 4415 DTHM---ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA----LLEQKWHV 4467
++ +L S+ KE+ Y + RL +L +++ + E +A +++ +
Sbjct: 1150 KENLGWQKLESEKAIKEKEY----EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQ 1205
Query: 4468 VSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEH 4527
+ ++ER+S L + + + + + LQ + L A+ +L + L QI+
Sbjct: 1206 CTQVVQERESLLVK-IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQ-- 1262
Query: 4528 KVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER-GR 4586
N++N + Q ++ +++ S+++ KN L S R + ++R ER R
Sbjct: 1263 ----NDLNQWKTQYSRKEEAIRKIE--SEREKSEREKNSLRSEIERLQAEIKRIEERCRR 1316
Query: 4587 SLDDARKRAKQFHEA----WKKLIDWLED----AESHLDSELEISNDPDKIKLQLSKHKE 4638
L+D+ + + E +++ ID L + +E E + D K+ + K
Sbjct: 1317 KLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
Query: 4639 FQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFL 4677
L Q + TT+ + LK K + E + ++ FL
Sbjct: 1377 TAMQLYECQLIDKTTL--DKLLKGKKSVEEVASEIQPFL 1413
Score = 44.7 bits (104), Expect = 0.003
Identities = 113/627 (18%), Positives = 238/627 (37%), Gaps = 78/627 (12%)
Query: 3241 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3300
D D+ + ++ RW ++K++ R+ L++ + ++D + WL D +
Sbjct: 850 DLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQ 909
Query: 3301 AN-QKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS-----AELADRE 3354
+ + + V + EQK L + ++ + +Q A S +LA
Sbjct: 910 DSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYT 969
Query: 3355 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP 3414
L ++ + T + S + ++ D+ + + FLS K L + +
Sbjct: 970 SGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKL 1029
Query: 3415 VGTQTAKIQQQI-----------IRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-- 3461
T+ +++++ ++K L+++++ + + Q SL L AE
Sbjct: 1030 KNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELD 1089
Query: 3462 -----------QGVLSEKIDSLQARYSEIQDRCCRKAALLDQ---------ALSNARLFG 3501
G + E + + EI+D R+ ++ D+ L AR
Sbjct: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR--- 1146
Query: 3502 EDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQA 3561
+ E E L W +K ++ K+++ + L + E N I+ +
Sbjct: 1147 QCEKENLGWQKLESEK--AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
Query: 3562 LLKQTTGE-EVLLIQEK-LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW 3619
Q E E LL++ K L+ K R + ++A TLE ++ + + +++
Sbjct: 1205 QCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQND 1264
Query: 3620 LREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRA 3679
L + + + S E I + + +++ ++E R +E+ R E+ R
Sbjct: 1265 LNQWKTQ------YSRKEEAIRKIESEREKSEREKNSLR------SEIERLQAEIK--RI 1310
Query: 3680 REGLDKLVSDANEQYKLVSDTIGQRVD-EIDAAIQRSQQYEQAADAELAWVAETKRKLMA 3738
E + + D+ + + +T R EID QR + E W +T KL+
Sbjct: 1311 EERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTS-KLVF 1369
Query: 3739 LGPIRLEQDQTTAQLQ----VQKAFSIDIIRHKDSMDELFSHRSEIFGTCG--------- 3785
G L + T QL + K +++ K S++E+ S G
Sbjct: 1370 DG---LRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASP 1426
Query: 3786 EEQKTVLQEKTESLIQQYEAISLLNSE 3812
+E+ ++++ K + LI + LL ++
Sbjct: 1427 KEKYSLVEAKRKKLISPESTVMLLEAQ 1453
Score = 43.5 bits (101), Expect = 0.006
Identities = 96/522 (18%), Positives = 195/522 (37%), Gaps = 93/522 (17%)
Query: 2814 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTL-- 2871
++ +L + W+ + K+ R L+ +++ + Y+ + + W+ D K + L
Sbjct: 859 KVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFG 918
Query: 2872 DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGIN----- 2926
D + L K + +E+ +R E + A++ NS + E + +G+
Sbjct: 919 DSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNI 978
Query: 2927 ------------------QNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 2968
++ A EL ++G + + E K K+E +
Sbjct: 979 PIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLE 1038
Query: 2969 HQLEIFDALGSQACS-----NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSD 3023
+L + S+ C+ ++NL+K +A+ +A ++ L+ + DG
Sbjct: 1039 EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKR------QAELDGKS 1092
Query: 3024 ASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGM 3083
A Q L + + ++K+ +N + ++E + V + F Q +
Sbjct: 1093 AKQNLDKC------YGQIKE-LNEKITRLTYEIEDEKRRRKSVEDRFDQQKN-------- 1137
Query: 3084 GAIGRDTDSLQS--QIEDVRLFLNKIHVLKLDIEASEAE---CRHMLEEEGTL------D 3132
D D LQ Q E L K+ K I+ E E R +L+EEGT +
Sbjct: 1138 -----DYDQLQKARQCEKENLGWQKLESEKA-IKEKEYEIERLRVLLQEEGTRKREYENE 1191
Query: 3133 LLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQ 3192
L ++ QC ++ + +E L + + +E +L+ L D A+ +
Sbjct: 1192 LAKASNRIQESKNQCTQVVQ----ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE 1247
Query: 3193 WVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME 3252
V +E QQ+ N L Q Q + K+ ++ +E + E
Sbjct: 1248 TRVKQRLECEKQQIQ--------------------NDLNQWKTQYSRKEEAIRKIESERE 1287
Query: 3253 EINARWNTLNKKVAQRIAQLQEALLHC-GKFQDALEPLLSWL 3293
+ N+L ++ + A+++ C K +D+ S L
Sbjct: 1288 KSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQL 1329
Score = 42.0 bits (97), Expect = 0.017
Identities = 171/973 (17%), Positives = 350/973 (35%), Gaps = 175/973 (17%)
Query: 1341 QQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDA--ITQEFMDLRTRYTALVTL 1398
+ Y + D EL Y+ F+ + Q S M D I +F D + Y LV
Sbjct: 574 EDYMKTIADLELH---YQEFIRNSQGS-----EMFGDDDKRKIQSQFTDAQKHYQTLVIQ 625
Query: 1399 TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKEST 1458
+ ++ + + + + +E T + ET
Sbjct: 626 LPGYPQHQTVTTTEITHHGTCQDVNHNKVIE---------------TNRENDKQETWMLM 670
Query: 1459 DIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAY 1518
+++K + + +T K +++ + I + + K + + + I+E LN L
Sbjct: 671 ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDML 730
Query: 1519 HDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSW------VGQAERALAG 1572
+ + + LQ+++ ++ L+ L LC+ + Q E L
Sbjct: 731 ANF--RGSEKYCYLQNEVFGLFQK--LENINGVTDGYLNSLCTVRALLQAILQTEDMLKV 786
Query: 1573 HQGRTTQQ-----DLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFME-----ENQT 1622
++ R T++ DL ++ + LK +++D+ + + AT+ +++ + Q
Sbjct: 787 YEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQY 846
Query: 1623 KLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENK 1682
L +L EK+ Q ++++ + ++ +LE+ + K L + K
Sbjct: 847 PLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAK 906
Query: 1683 KKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQC 1742
++ D+L ++ + L EQ + S G D ++ + + K
Sbjct: 907 RRQDSLESMKFGDSNTVMRFLN-----EQKNLHSEISGKRDKSEEVQKIAELCANSIKDY 961
Query: 1743 EMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQ 1802
E+ A + L N + Q+ ++ Q+ ++ +Y L +
Sbjct: 962 ELQLASYTSGLETLLNIPIKRTMIQS------------PSGVILQEAADVHARYIELLTR 1009
Query: 1803 SEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL--------ENMHKGGSSPETLPSL 1854
S + + E+ K L+D K + +E E+EL EN +K + L
Sbjct: 1010 SGDYYRFLS----EMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKY 1065
Query: 1855 LKRQGSFSEDVISHKGDLRFVTISGQKVL-DMENSFKEGKEPSEIGNLVKDKLKDATERY 1913
F + S + R + G+ +++ + + KE +E + +++D R
Sbjct: 1066 QAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRR 1125
Query: 1914 TALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQ 1973
++ + + Q +N D LQ Q CE +E
Sbjct: 1126 KSVEDR--------------FDQQKNDYDQLQKARQ-CE------------------KEN 1152
Query: 1974 LATTK-QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYS 2032
L K + ++ + E + +E+L R +++ EG ++ +
Sbjct: 1153 LGWQKLESEKAIKEKEYEIERL----RVLLQEEGTRKREYEN-----------------E 1191
Query: 2033 LAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLK 2092
LA+ S+ +Q++ Q V + ESLL I +EQ+ A +L+
Sbjct: 1192 LAKASNRIQESKNQCTQVVQERESLLVKIKVLEQD-----------------KARLQRLE 1234
Query: 2093 QDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKL 2152
++ R KS+LEA + R +E L + S++ E + + E+E S ++
Sbjct: 1235 DELNRAKSTLEAETRVKQR-LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREK 1293
Query: 2153 LPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL- 2211
E L ++++ E R L + Q +L E Q +D L
Sbjct: 1294 NSLRSEIERLQAEIKRIEERCRRKLEDSTRETQ---------SQLETERSRYQREIDKLR 1344
Query: 2212 -----EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQ---------KTVKEREKDASS 2257
H T+ + C + +D + LRK T +Q T+ + K S
Sbjct: 1345 QRPYGSHRETQ-TECEWTVDTSKLV--FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKS 1401
Query: 2258 CQEQLDEFRKLVR 2270
+E E + +R
Sbjct: 1402 VEEVASEIQPFLR 1414
Score = 39.7 bits (91), Expect = 0.082
Identities = 28/68 (41%), Positives = 36/68 (52%), Gaps = 4/68 (5%)
Query: 5330 SNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDT 5389
S SS + + A +S SR GSR+GSR+GSR+ SRRGS FD S
Sbjct: 2208 SVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGS----FDATGNSSYSYSY 2263
Query: 5390 SESSAAGG 5397
S SS++ G
Sbjct: 2264 SFSSSSIG 2271
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 361 bits (927), Expect = 9e-99
Identities = 417/1703 (24%), Positives = 728/1703 (42%), Gaps = 260/1703 (15%)
Query: 66 ERAVVR-VADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKL 124
ER+ ++ +ADER+ VQKKTFTKWVN HL +V I DLY DLRDG LI LLEVLSG +L
Sbjct: 41 ERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERL 100
Query: 125 PRE-KGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS 183
P+ KGRMR H L+NV AL FLK+++V L N+ + DI DGN +LTLGLIWTIIL FQI
Sbjct: 101 PKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQ 160
Query: 184 DIYISGESG--DMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLV 241
DI + E SAK+ LLLW Q TAGY + NF++ W DG FNALIH++RPDL+
Sbjct: 161 DISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLI 220
Query: 242 DMERVQIQSNRENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKV 300
D ++++ + NL+ AF +AE+ LG+T+LLD ED+ V PDEKS+ITYV + Y F K+
Sbjct: 221 DFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKM 280
Query: 301 PE---GGEGI-----SATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKAL 352
G+ I +A E + ++Y+S L+ WI+Q I+++++ F + V ++
Sbjct: 281 KALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQ 340
Query: 353 YNQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKL---PQGYHPNDVEEEWGKLI 409
+ ++ E K EKG +E L ++ + K+ +G +D+ + W +L
Sbjct: 341 LQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLE 400
Query: 410 IEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQAD-------AAHLE 462
ERE +LR + R E L Q+A + A E L+ + + D A
Sbjct: 401 KAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAA 460
Query: 463 SGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFR---VMRLQDELVTL 519
+ + E+D+ Y + + ++ + L ENY+ ++ + R V+RL + L+ L
Sbjct: 461 TKKHEAIETDIAAYEERVQAVVAVARE----LEAENYHDIKRITARKDNVIRLWEYLLEL 516
Query: 520 ------RLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAE 573
RLE NL + F + + W E
Sbjct: 517 LRARRQRLE-MNLGLQKIFQEMLYI-----------------------MDWM------DE 546
Query: 574 LVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELG 633
+ + S+D G + L VE++ K E + +Q E + ++ S ++
Sbjct: 547 MKVLVLSQDYG------KHLLGVEDLLQKHTLVE-----ADIGIQAERVRGVNASAQKFA 595
Query: 634 SSVKEARLYEGKMSQNFHTSYAETLGKLETQY---CKLKETSSFRMRHLQSLHKFVSRAT 690
+ + + + ++ + + + +E Y C+L R+ + L KF
Sbjct: 596 TDGEGYKPCDPQVIR-------DRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMA 648
Query: 691 AELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLEN 750
E W+ EKE+ + D+ + +++ + E+ + F E + E
Sbjct: 649 EEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEE 708
Query: 751 HPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK 810
H + + ++ Q ++QL ++ ++E + QF +DA +++++ + D +K
Sbjct: 709 HFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAW---MLDILK 765
Query: 811 RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPD------ 864
S D + L++ D E++ + ++ +L ++ + Q SPD
Sbjct: 766 IVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLS 825
Query: 865 -------HVLKNT-ISVKAVCDYRQIEITICKNDECVL--EDNSQRTKWKVISPTGNEAM 914
V + T + +A+ D + + D C L ++ Q I +
Sbjct: 826 GIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 885
Query: 915 VPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSL--------ISWNYLRKD 966
V F P + ASRV Q L H H + K + W+ R+
Sbjct: 886 VIQHRFESLEPEMN--NQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL 943
Query: 967 LDLVQTWNLEKLR-SSAPGECHQIMKNLQAHYE--DFLQDSRDSVLFSVADRLRL---EE 1020
+D + L L + EC++ ++ + + QD + + +A + +L E
Sbjct: 944 VDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMER 1003
Query: 1021 EVEACKARFQHLMKSMEN-EDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSR- 1078
++ A +A+ L K E E + A+ +S L I EE + + R SL +
Sbjct: 1004 DLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASK 1063
Query: 1079 --------TDRDAW---QDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF--------- 1118
D +W A+ + +T + ++L + + + + D++
Sbjct: 1064 LQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRD 1123
Query: 1119 ----LHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVK 1174
+ Q + + LR L L + ++ + N L + ++D K
Sbjct: 1124 MGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRD----TK 1179
Query: 1175 GYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRL 1234
E L+ +E VLA +TL + +K + + +D K V E RL
Sbjct: 1180 QAEAFLNNQEYVLAHTEMP----TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRL 1235
Query: 1235 TPERNLDLERYQEKGSQLQERWHR----VIAQLEIRQSELESIQEVLGDYRACHGTLIKW 1290
+ N++ +R QEK + +R HR ++L +R + +Q+ L D + L W
Sbjct: 1236 VSDGNINSDRIQEKVDSIDDR-HRKNRETASELLMRLKDNRDLQKFLQDCQ----ELSLW 1290
Query: 1291 IEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY 1350
I E + M +++R L + + A AE+ N+ LD+ +K
Sbjct: 1291 INEKMLTAQDM---SYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEG---------- 1337
Query: 1351 ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDAL 1410
+QL++ K E+ + ++ L + L + T + + DA
Sbjct: 1338 -MQLISEKPETEA----------------VVKEKLTGLHKMWEVLESTTQTKAQRLFDA- 1379
Query: 1411 RRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVL 1470
+ + + +L W+ L Q + K+ T + + +QQ+L
Sbjct: 1380 -----------NKAELFTQSCADLDKWLHGLESQIQ---SDDYGKDLTSVNILLKKQQML 1425
Query: 1471 SEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQIS------EQLNALNKAYHDLCDG 1524
++ +K+++ E +Q L++ G E + K+++ E L LN+ H+L
Sbjct: 1426 ENQMEVRKKEIEELQSQAQA-LSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNL--- 1481
Query: 1525 SANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQ-AERALAGHQGRTTQQDLS 1583
L S+ HQ ++ +ED WVG+ A + G Q
Sbjct: 1482 -------LASKEIHQ------------FNRDVEDEILWVGERMPLATSTDHGHNLQTVQL 1522
Query: 1584 ALQKNQSDLKDLQ------DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLH 1637
++KNQ+ K++Q DDI R+ + T + + LS A+R++L
Sbjct: 1523 LIKKNQTLQKEIQGHQPRIDDIFERSQNIVT-----------DSSSLSAE---AIRQRLA 1568
Query: 1638 QAKEQYEALQEETRVAQKELEEA 1660
K+ + L EET + LEEA
Sbjct: 1569 DLKQLWGLLIEETEKRHRRLEEA 1591
Score = 201 bits (511), Expect = 2e-50
Identities = 326/1644 (19%), Positives = 687/1644 (41%), Gaps = 106/1644 (6%)
Query: 3249 HDMEEINAR-------WNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIA 3301
HD++ I AR W L + + R +L+ L FQ+ L ++ W+ + + L+
Sbjct: 494 HDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVL 552
Query: 3302 NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAE---LADREKITG 3358
+Q V+ +Q+ L++ + + V + A + A E D + I
Sbjct: 553 SQDY-GKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRD 611
Query: 3359 QLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQ 3418
++ +E + EL AA R+ +LE+ L K F E AE + ++K+ +S+ G
Sbjct: 612 RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAE--EEGWIREKEKILSSDDYGKD 669
Query: 3419 TAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDS----LQA 3474
+ + + +H+A E+++ + QA+K G+ + AE+ SEKI ++
Sbjct: 670 LTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMI-----AEEHFGSEKIRERIIYIRE 724
Query: 3475 RYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFV--KDFKQDVLH 3532
+++ ++ + L++A S F D ++ W+ ++ +SS V ++ L
Sbjct: 725 QWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLV 783
Query: 3533 RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTS 3592
++H D + EEI N + +D + AL ++ E ++ +L GI+ RY ++ +
Sbjct: 784 KKHKD---VAEEIANYRPTLDTLHEQASALPQEHA--ESPDVRGRLSGIEERYKEVAELT 838
Query: 3593 SKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTG-EQIPQFQQRQKELK 3651
+ L+ L F S + W+ E E+ L + Q P E + Q R + L+
Sbjct: 839 RLRKQALQDTLALYKMF-SEADACELWIDEKEQWL--NNMQIPEKLEDLEVIQHRFESLE 895
Query: 3652 KEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAA 3711
E+ + VN+++R L+ +E + N ++ + + ++ D + +A
Sbjct: 896 PEMNNQASRVAVVNQIARQLMHSGHPSEKE-IKAQQDKLNTRWSQFRELVDRKKDALLSA 954
Query: 3712 IQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMD 3771
+ Q Y + +W+ E + + + + + A + D++ + +
Sbjct: 955 LS-IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLS 1013
Query: 3772 ELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 3831
+L ++ ++ + +L E + +E + R A L A L QF
Sbjct: 1014 DLQKEAEKLESEHPDQAQAILSRLAE-ISDVWEEMKTTLKNREASLGEASKL-QQFLRDL 1071
Query: 3832 EELSPWIEETRALIAQ--LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL 3889
++ W+ T+ IA +P+ + E+L Q E ++ I ++ K+ +G +
Sbjct: 1072 DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHEN---IKNEIDNYEEDYQKMRDMGEMV 1128
Query: 3890 KELNPEEGEM-VEEKYQKAENMYAQIKE--EVRQRALALDEAVSQSTQITEFHDKIEPML 3946
+ + M + ++ Q + + ++ + E RQ L+ A Q + T+ + E L
Sbjct: 1129 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTK---QAEAFL 1185
Query: 3947 ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4006
E + + MP + + I + ++ + A+ G L+
Sbjct: 1186 NNQEYVLAHTEMPTTL----EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLV----- 1236
Query: 4007 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD-- 4064
+D ++ + IQ+K+D + + A E ++ D +L +KF D L I +
Sbjct: 1237 SDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWINEKM 1295
Query: 4065 --TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEK 4122
QD+ +D E+ + +K Q AE + E L+ I G LI ETE
Sbjct: 1296 LTAQDMSYD-EARNLHSKWLKHQAFMAELASNK-----EWLDKIEKEGMQLISEKPETEA 1349
Query: 4123 PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP 4182
V++ + ++ WE L T + + ++L DA +A + + + + WL ++ +
Sbjct: 1350 V-VKEKLTGLHKMWEVLESTTQTKAQRLFDANKAEL-FTQSCADLDKWLHGLESQIQS-D 1406
Query: 4183 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK--KATDETDRDIIREPLT 4240
G DL +V L + + + ++ ++ E+E+L Q + + + K+TDE D + T
Sbjct: 1407 DYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQ-T 1465
Query: 4241 ELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKV 4300
+ L E L E R+H L A + QF +E+ + W+ L + + +
Sbjct: 1466 KFMELLEPLNE----RKHNLL-ASKEIHQFNRDVEDEILWVGERMPLATSTDH-GHNLQT 1519
Query: 4301 IEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQ 4360
+++ + K+ L+ ++ HQ ++ + + ++ S+ A ++R RL + Q W +++
Sbjct: 1520 VQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIE 1579
Query: 4361 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMEL 4420
+TE+R ++L+ +AQ ++ + + ++ E + + + ++A L H L
Sbjct: 1580 ETEKRHRRLEEA-HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-EQSAVSMLKKHQIL 1637
Query: 4421 YSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4480
++ ET +QL R ++ D + + +++ + + EER+ KL+
Sbjct: 1638 EQAVEDYAETVHQLSKTSRALV--ADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLD 1695
Query: 4481 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEV-NAHRD 4539
E L + + + W+ E + + Q E + FA + N ++
Sbjct: 1696 ERHRL-FQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQ-ERFREFARDTGNIGQE 1753
Query: 4540 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFH 4599
++ ++ ++L S D I + W +++ R + L + + K +H
Sbjct: 1754 RVDTVNHLADEL-INSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYH 1812
Query: 4600 EAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQ---KTLGGK-QPVYDTTIR 4655
+A K++ ++D L EL D + ++ H F+ + LG + + + + R
Sbjct: 1813 DA-KEIFGRIQDKHKKLPEEL--GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAAR 1869
Query: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
A +D QK +N EV + W ++ R+ +L + +F ++ L
Sbjct: 1870 LQAAYAGDK--ADDIQKREN---EVLEAWKSLLDACESRRVRLVDT-GDKFRFFSMVRDL 1923
Query: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775
+ W+ V Q+ E Q D+ V LM+ H+ + E+ R + G+ L+
Sbjct: 1924 MLWMEDVIRQI-EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKH 1982
Query: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 4835
+ +K +L +L+ + + + L L+ + RD + WL E L
Sbjct: 1983 YASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRD-ASVAEAWLLGQEPYLS 2041
Query: 4836 FRGALPDDTEALQSLIDTHKEFMK 4859
R + + ++ LI H+ F K
Sbjct: 2042 SR-EIGQSVDEVEKLIKRHEAFEK 2064
Score = 171 bits (434), Expect = 1e-41
Identities = 326/1760 (18%), Positives = 699/1760 (39%), Gaps = 173/1760 (9%)
Query: 3281 KFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATV------ 3334
K++ LL W+ T ++ N+K ++ V + Q+Q + + K T
Sbjct: 306 KYESLASDLLEWIEQTIIILNNRKFANSLVGV-QQQLQAFNTYRTVEKPPKFTEKGNLEV 364
Query: 3335 ------DMLQAEGGRIAQSAE---LADREKITGQLESLESRWTELLSKAAARQKQLEDIL 3385
++A ++ E ++D K +LE E L RQ++LE
Sbjct: 365 LLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQ-- 422
Query: 3386 VLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3445
LA++F A +LS ++ L + + G ++ +H+A+E DI + V
Sbjct: 423 -LARRFDRKAAMRETWLSENQR-LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQA 480
Query: 3446 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 3505
V + + L + + + + K D++ + + + + L+ L ++F ++ +
Sbjct: 481 VVAVARELEAENYHDIKRITARK-DNVIRLWEYLLELLRARRQRLEMNLGLQKIF-QEML 538
Query: 3506 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK-------- 3557
+++W+ E+ K VL + + HL E+++ + V+ I
Sbjct: 539 YIMDWMDEM------------KVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRG 586
Query: 3558 -NGQALLKQTTGE-----EVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQS 3611
N A T GE + +I++++ ++ Y ++ +++ LE++R+L F
Sbjct: 587 VNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWE 646
Query: 3612 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL 3671
EE GW+RE E+ L++ + + + + + +HR D ++ S
Sbjct: 647 MAEE-EGWIREKEKILSSD-----------DYGKDLTSVMRLLSKHRAFEDEMSGRSGHF 694
Query: 3672 LELVPWRAREGLDKLVSD-------------ANEQYKLVSDTIGQRVDEIDAAIQRSQQY 3718
+ + +EG D + + EQ+ + R ++ A Q+
Sbjct: 695 EQAI----KEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA-SLLHQF 749
Query: 3719 EQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRS 3778
+ AD AW+ + L + + D+ + Q V+K HKD +E+ ++R
Sbjct: 750 QADADDIDAWMLDI---LKIVSSSDVGHDEYSTQSLVKK--------HKDVAEEIANYRP 798
Query: 3779 EIFGTCGEEQKTVLQEKTES---------LIQQYEAISLLNSERYARLERAQVLVNQFWE 3829
+ T E+ + QE ES + ++Y+ ++ L R L+ L F E
Sbjct: 799 TL-DTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 857
Query: 3830 TYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL 3889
+ WI+E + + P E L Q L + + + +I QL
Sbjct: 858 A-DACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQL 915
Query: 3890 KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 3949
+ ++ + K ++Q +E V ++ AL A+S E ++ + E
Sbjct: 916 MHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKT 975
Query: 3950 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4009
+ + S + + + R+ + +L ++ L++ E+L S+ D+
Sbjct: 976 KVIESTQDLGNDLAGVMALQRKLTGMER----DLVAIEAKLSDLQKEAEKL--ESEHPDQ 1029
Query: 4010 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4069
A+ I +L ++ WE++K + RE + +L ++F D+ + + TQ +
Sbjct: 1030 ---AQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQTAI 1085
Query: 4070 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4129
+ P K + E IK E D E+ + +R +G + + + +R+ +
Sbjct: 1086 ASEDMPNTLTEAEKLLTQH-ENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRL 1144
Query: 4130 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNT--VIKLCTMPPVGTD 4187
++ W L+K W+ R L + +DT QA +L+N V+ MP T
Sbjct: 1145 QALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEA-FLNNQEYVLAHTEMP---TT 1200
Query: 4188 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4247
L + + + ++F + + ++ + G ++ +DR I+E + +
Sbjct: 1201 LEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDR--IQEKVDSIDDRHR 1258
Query: 4248 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAK 4307
E + +L+ L +F +EL W+ E++L AQ + + + + K
Sbjct: 1259 KNRETASELLMRLKDNR-DLQKFLQDCQELSLWIN--EKMLTAQDMSYDEARNLHSKWLK 1315
Query: 4308 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQ 4367
H ++ +++ ++ + K G +L+ +A ++ +L +++ WE VL+ T + +
Sbjct: 1316 HQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV-VKEKLTGLHKMWE-VLESTTQTKA 1373
Query: 4368 QLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAK 4427
Q +A+ F D L +ESQ+ S G + L L +Q++ +
Sbjct: 1374 QRLFDANKAELFTQSCADLDKWLHGLESQIQ-SDDYGKDLTSVNILLKKQQMLENQMEVR 1432
Query: 4428 EETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLAT 4487
++ +L + + + + S + + ++ K+ + + ERK L + +
Sbjct: 1433 KKEIEELQSQAQAL---SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIH- 1488
Query: 4488 EFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQT 4547
+F +++ I W+ L ++ L TV I++++ E+ H+ +I ++ +
Sbjct: 1489 QFNRDVEDEILWVG-ERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFER 1547
Query: 4548 GNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLID 4607
+ S I+ L ++ W +++ + +R R L++A RA+Q++ +
Sbjct: 1548 SQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAH-RAQQYYFDAAEAEA 1606
Query: 4608 WLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL-----KE 4662
W+ + E ++ SE + ++ + + L KH+ ++ + +T RAL E
Sbjct: 1607 WMSEQELYMMSEEKAKDEQSAVSM-LKKHQILEQAVEDYAETVHQLSKTSRALVADSHPE 1665
Query: 4663 KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKV 4722
+ K+D ++D + GK ER H+L Q + L W+ +
Sbjct: 1666 SERISMRQSKVDKLYAGLKDLAEERRGKLDER-HRLF-------QLNREVDDLEQWIAER 1717
Query: 4723 EPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG----KRTGTVQVLKRSGRELIENSRDDT 4778
E +A + D + V L + + F ++ G +R TV L ELI + D
Sbjct: 1718 EV-VAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHL---ADELINSGHSDA 1773
Query: 4779 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 4838
+ L+ W + +L ++ L + + + + D + + ++ G
Sbjct: 1774 ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELG 1833
Query: 4839 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIR 4898
+ E LQ + T + ++ + + + A + A D I +
Sbjct: 1834 RDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDI----------Q 1883
Query: 4899 ARFEEVLTWAKQHQQRLETALSELVANAE------LLEELLAWIQWAETTLIQRDQEPIP 4952
R EVL K E+ LV + ++ +L+ W+ E + Q + + P
Sbjct: 1884 KRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWM---EDVIRQIEAQEKP 1940
Query: 4953 QNIDRVKALIAEHQTFMEEM 4972
+++ V+ L+ HQ E+
Sbjct: 1941 RDVSSVELLMNNHQGIKAEI 1960
Score = 162 bits (409), Expect = 1e-38
Identities = 282/1473 (19%), Positives = 612/1473 (41%), Gaps = 97/1473 (6%)
Query: 3254 INARWNTLNKKVAQRIAQLQEA-LLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV 3312
I +W L + A R +L+EA LLH +FQ + + +W+ D +++++ EY
Sbjct: 722 IREQWANLEQLSAIRKKRLEEASLLH--QFQADADDIDAWMLDILKIVSSSDVGHDEYST 779
Query: 3313 VKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLS 3372
++ +++ K + + + + T+D L + + Q E A+ + G+L +E R+ E+
Sbjct: 780 -QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ--EHAESPDVRGRLSGIEERYKEVAE 836
Query: 3373 KAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSE-PVGTQTAKIQQQIIRHKA 3431
R++ L+D L L K F E A+ ++ E+ L N + P + ++ Q R ++
Sbjct: 837 LTRLRKQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQH--RFES 893
Query: 3432 LEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLD 3491
LE ++ N A+ V +I + L P+E+ + +++ D L R+S+ ++ RK L
Sbjct: 894 LEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ-DKLNTRWSQFRELVDRKKDALL 952
Query: 3492 QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDV---------LHRQHADHLALN 3542
ALS E E +W+ E + S +D D+ L D +A+
Sbjct: 953 SALSIQNYHLECN-ETKSWIREKTKVIEST--QDLGNDLAGVMALQRKLTGMERDLVAIE 1009
Query: 3543 EEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQA 3602
++ + +K ++ L+ ++ I +L I + ++ T +L +A
Sbjct: 1010 AKLSDLQKEAEK--------LESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEA 1061
Query: 3603 RQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQ---IPQFQQRQKELKKEVMEHRL 3659
+L +F ++ WL + +A+ + E + Q + + E+ +++
Sbjct: 1062 SKLQ-QFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQK 1120
Query: 3660 VLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE 3719
+ D V++ + R+ L L + NE +K+ + Q + A Q+ +
Sbjct: 1121 MRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENR--QNLLSQSHAYQQFLRDT 1178
Query: 3720 QAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSE 3779
+ A+A L + ++A + + A ++ Q+ F + +++ ++ +
Sbjct: 1179 KQAEAFL----NNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRR 1234
Query: 3780 IFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIE 3839
+ G +QEK +S+ ++ SE RL+ + L +F + +ELS WI
Sbjct: 1235 LVSD-GNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWIN 1292
Query: 3840 ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM 3899
E + L AQ S + L + + + +A +K +DK+ K G QL PE +
Sbjct: 1293 E-KMLTAQDMSYD-EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV 1350
Query: 3900 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 3959
V+EK M+ ++ + +A L +A +++ T+ ++ L LE+
Sbjct: 1351 VKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDKWLHGLES-------- 1401
Query: 3960 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD-LAAKEIQD 4018
+ D + ++ + + L+ E K+ EEL ++Q ++ + E+
Sbjct: 1402 ---QIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDS 1458
Query: 4019 KLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGID 4078
K + + ++ ER+ L E+ +F D+ + + + + + G +
Sbjct: 1459 KRLTVQTKFMELLEPLNERKHNLLASKEI-HQFNRDVEDEILWVGERMPLATSTDH-GHN 1516
Query: 4079 PSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWEN 4138
++ ++ +T+++E G ++ I +++ +R+ + ++ W
Sbjct: 1517 LQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL 1576
Query: 4139 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKD-QLNE 4197
L + ++R +LE+A +A Y D +A W+ + + + + + V + ++
Sbjct: 1577 LIEETEKRHRRLEEAHRAQQYYFDAAEAEA-WMSEQELYMMSEEKAKDEQSAVSMLKKHQ 1635
Query: 4198 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4257
+ E VE Y + + +L+ ++ + E++R +R+ +++ L+ L + R+
Sbjct: 1636 ILEQAVEDYAETVH--QLSKTSRALVADSHPESERISMRQ--SKVDKLYAGLKDLAEERR 1691
Query: 4258 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA 4317
KL+ L Q +++L W+ E + + V ++ ++
Sbjct: 1692 GKLDERH-RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI 1750
Query: 4318 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4377
Q V+TVN +EL+ +S DA+++ + +N+ W +L+ + R Q L ++ + +
Sbjct: 1751 GQERVDTVNHLADELI-NSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHK 1809
Query: 4378 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT-HMELYSQLKAKEETYNQLL- 4435
+H E F R++ + G + E L H ++A QL
Sbjct: 1810 FYHDAKEIF----GRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQE 1865
Query: 4436 DKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQE 4495
D RL D + ++ L + W + E R+ +L + + F + +++
Sbjct: 1866 DAARLQAAYAGDKADDIQKRENEVL--EAWKSLLDACESRRVRLVDTGD-KFRFFSMVRD 1922
Query: 4496 FINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS 4555
+ W+ + + P + + L + H+ E++A D + G L L+
Sbjct: 1923 LMLWMEDVIRQIEAQEKPRDVSSVELL-MNNHQGIKAEIDARNDSFTTCIELGKSL--LA 1979
Query: 4556 QKQDVVL-IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAES 4614
+K IK L+ + + ++++ + +R L + QF WL E
Sbjct: 1980 RKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILE-VHQFSRDASVAEAWLLGQEP 2038
Query: 4615 HLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYD-----TTI--------RTGRALK 4661
+L S EI D+++ + +H+ F+K+ + TT+ + K
Sbjct: 2039 YLSSR-EIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERK 2097
Query: 4662 EKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
+ PE S K+ E + +WDT G+ V +
Sbjct: 2098 RRPPSPEPSTKVSE-EAESQQQWDTSKGEQVSQ 2129
Score = 154 bits (389), Expect = 2e-36
Identities = 310/1641 (18%), Positives = 660/1641 (40%), Gaps = 214/1641 (13%)
Query: 1596 QDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQK 1655
Q+ ++ A F E ++ ENQ +S + A +++EA++ + ++
Sbjct: 417 QEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEE 476
Query: 1656 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 1715
++ V A + E E K + K + L +++ + + Q L G++++
Sbjct: 477 RVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQE 536
Query: 1716 SL-------EKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQA 1768
L E L + Y E L ++ +++A ++ Q + SAQ
Sbjct: 537 MLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEA---DIGIQAERVRGVNASAQK 593
Query: 1769 FLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFE 1828
F G P + Q+++ ++ ++ Y L Q AE + L KF + E E
Sbjct: 594 FATD-GEGYKPCDPQVIRDRVAHMEFCYQ-ELCQLAAERRARLEESRRLWKFFWEMAEEE 651
Query: 1829 SWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENS 1888
W+ EK L + G ++ LL + +F +++ G E +
Sbjct: 652 GWIREKEKILSS-DDYGKDLTSVMRLLSKHRAFEDEMSGRSG-------------HFEQA 697
Query: 1889 FKEGKEPSEIGNLVKDKLKDA----------TERYTALHSKCTRLGSHLNMLLGQYHQFQ 1938
KEG++ + +K+++ E+ +A+ K S L HQFQ
Sbjct: 698 IKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLL-------HQFQ 750
Query: 1939 NSADSLQAWMQACEANVEKLLSDT-VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKV 1997
AD + AWM ++ K++S + V D Q + K + EE+A ++ ++ L +
Sbjct: 751 ADADDIDAWM----LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQ 806
Query: 1998 ARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESL 2057
A + + E +PD V+ I ++ ++ R LQ +A + E+ ++
Sbjct: 807 ASALPQEHAE-SPD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEA-DAC 861
Query: 2058 LQSIGEVEQNLEGKQVSSLSSG--VIQEALATNMKLKQDIARQKSSLEATREMVTRFMET 2115
I E EQ L Q+ VIQ + L+ ++ Q S + ++ + M +
Sbjct: 862 ELWIDEKEQWLNNMQIPEKLEDLEVIQHRFES---LEPEMNNQASRVAVVNQIARQLMHS 918
Query: 2116 ADSTTAAV--LQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENK 2173
+ + Q KL +F +L ++K++ L L Q E + + ++ K
Sbjct: 919 GHPSEKEIKAQQDKLNTRWSQFRELV--DRKKDALLSALSIQNYHLE--CNETKSWIREK 974
Query: 2174 SRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDR 2233
++++ S QD+ + + L ++ + +L +E +++L L+ +H D+
Sbjct: 975 TKVIES----TQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLE-SEHPDQ 1029
Query: 2234 VQ-------NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT 2286
Q + + E++ T+K RE +L +F + + FQ WL T+ +I
Sbjct: 1030 AQAILSRLAEISDVWEEMKTTLKNREASLGEA-SKLQQFLRDLDDFQSWLSRTQTAIASE 1088
Query: 2287 ETSMSAKELEK---QIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG 2343
+ + E EK Q E++K+ +D++ EE K + ++ +QG+T
Sbjct: 1089 DMPNTLTEAEKLLTQHENIKNEIDNY-------EEDYQKMRDMGEMV-------TQGQTD 1134
Query: 2344 SILPSVGSSVGSVN-GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEE 2402
+ + + +++ G++ + E + ++ + Y++ L + +++ +A LN E
Sbjct: 1135 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQF---LRDTKQA-EAFLNNQEY 1190
Query: 2403 V--HKEANSVLQWLES----KEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK 2456
V H E + L+ E+ +E+ + +MDA E + A E+ + +++ NS +
Sbjct: 1191 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDA-----NEEKINAVVETGRRLVSDGNINSDR 1245
Query: 2457 IQ-----------KVKEALAGLLVTYPNSQEAENWKKIQEEL----NSRWERATEVTVAR 2501
IQ K +E + LL+ ++++ + + + +EL N + A +++
Sbjct: 1246 IQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDE 1305
Query: 2502 QRQLEESASHLACFQAAESQLRPWL--MEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKE 2559
R L F A + + WL +EKE M L ++K + + ++KE
Sbjct: 1306 ARNLHSKWLKHQAFMAELASNKEWLDKIEKEGM------------QLISEKPETEAVVKE 1353
Query: 2560 -FEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ 2618
+ E L Q D + + + Q +L L+ SQI
Sbjct: 1354 KLTGLHKMWEVLESTTQTKAQRLFDAN--------KAELFTQSCADLDKWLHGLESQIQS 1405
Query: 2619 AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 2678
D + + +V L Q + Q E K+++E E++S + L E
Sbjct: 1406 ------------DDYGKDLTSVNILLKKQQMLENQMEVRKKEIE---ELQSQAQALSQEG 1450
Query: 2679 KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 2738
K DE+ KRL ++ LE L + N L A QF +
Sbjct: 1451 KST----DEVD------------SKRLTVQTKFMELLEPLNERKHNLL--ASKEIHQFNR 1492
Query: 2739 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 2798
++ W+ ++ A + L+ +Q +++N+ QK + H + I +++
Sbjct: 1493 DVEDEILWVGERM-PLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNI 1551
Query: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858
+ ++ +L +LK W L ++T R RL++ +AQ+Y + + W+
Sbjct: 1552 VTD-SSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA-HRAQQYYFDAAEAEAWMS 1609
Query: 2859 DCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI 2918
+ + M D S L + + + VE + L+ + L+ S + + I
Sbjct: 1610 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
Query: 2919 RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG 2978
++ +++ + + + + G L+E R R FQ + ++V+ + + + +
Sbjct: 1670 SMRQSKVDKLYAGLKDLAEERRGKLDE---RHRLFQ-----LNREVDDLEQWIAEREVVA 1721
Query: 2979 SQACSNKNLEKLRAQQEVLQAL--------EPQVDYLRNFTQGLVEDAPDGSDASQLLHQ 3030
++ E + QE + + +VD + + L+ SDA+ +
Sbjct: 1722 GSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSG--HSDAATIAEW 1779
Query: 3031 AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT 3090
+ + + ++ + +++ ++ E + +F+ +E+F ++ D +L +GRD
Sbjct: 1780 KDGLNEAWADLLELIDTRTQILAASYE-LHKFYHDAKEIFGRIQDKHKKLP--EELGRDQ 1836
Query: 3091 DSLQSQIEDVRLFLNKIH-VLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGK 3149
+++++ L ++H + DI+A + R + E+ L + + + K+ +
Sbjct: 1837 NTVET--------LQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENE 1888
Query: 3150 LTERGKARQEQLELTLGRVED 3170
+ E K+ + E R+ D
Sbjct: 1889 VLEAWKSLLDACESRRVRLVD 1909
Score = 147 bits (371), Expect = 3e-34
Identities = 312/1712 (18%), Positives = 703/1712 (41%), Gaps = 146/1712 (8%)
Query: 2372 MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2431
+SD+N +E+L HER+ +L+ L R E++ + A + +E L + S
Sbjct: 389 ISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQD 448
Query: 2432 K----TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKI---- 2483
V+A + ++A ++ ++Q V V EAEN+ I
Sbjct: 449 NFGFDLPAVEAATKKHEAIETDIAAYEERVQAV--------VAVARELEAENYHDIKRIT 500
Query: 2484 --QEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 2541
++ + WE E+ AR+++LE + FQ + W+ E ++++ LS
Sbjct: 501 ARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEM-LYIMDWMDEMKVLV-----LSQ 554
Query: 2542 D--PNMLNAQKQQVQFMLKEFE--ARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQ 2596
D ++L + + L E + + ++ +N +AQ T G G ++ +
Sbjct: 555 DYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVA 614
Query: 2597 SINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSA------I 2650
+ + EL R +++++ S + + +++E+ + ++ + S+ +
Sbjct: 615 HMEFCYQELCQLAAERRARLEE----SRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDL 670
Query: 2651 STQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVAL 2710
++ + + E+ + +KE + + E E + +++++R+ +
Sbjct: 671 TSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAE------EHFGSEKIRERIIYIRE 724
Query: 2711 PLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 2770
LE L+A R RL+ A + QFQ D++ W+ D + + + QS
Sbjct: 725 QWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLD-ILKIVSSSDVGHDEYSTQSL 782
Query: 2771 LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGE--EKRTLQNQLVELKNHWEELSKK 2828
++++++ + + + + + + + +L P E E ++ +L ++ ++E+++
Sbjct: 783 VKKHKDVAEEIANYRPTLDTLHEQASAL-----PQEHAESPDVRGRLSGIEERYKEVAEL 837
Query: 2829 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 2888
T R+ L+D + + + + WI++ + ++ +++ LE R +++
Sbjct: 838 TRLRKQALQDTLALYKMFS-EADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEP 896
Query: 2889 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQ 2948
E+ + S + ++N A L++S E I+ ++ +N E + K +L
Sbjct: 897 EMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALS 956
Query: 2949 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE-KLRAQQEVLQALEPQVDYL 3007
++ + + + +E LG+ L+ KL + L A+E ++ L
Sbjct: 957 -IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL 1015
Query: 3008 RNFTQGLVEDAPDGSDA--SQLLHQAEVAQQEFLEVKQRVNS--GCVMMENKLEGIGQFH 3063
+ + L + PD + A S+L ++V ++ +K R S ++ L + F
Sbjct: 1016 QKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQ 1075
Query: 3064 CRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRH 3123
+ + +A D M + + L +Q E+++ N+I + D +
Sbjct: 1076 SWLSRTQTAIASED-----MPNTLTEAEKLLTQHENIK---NEIDNYEEDYQKMRDMGEM 1127
Query: 3124 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG----LN 3179
+ + + + L++ L+AL+ +L + + RQ L + + F R K LN
Sbjct: 1128 VTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQS-HAYQQFLRDTKQAEAFLN 1186
Query: 3180 DATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAG 3239
+ E + G E I Q+ DF +D + K+ V G+ L+
Sbjct: 1187 NQEYVLAHTEMPTTLEGAEAAIKKQE--DF----MTTMDANEEKINAVVETGRRLVSDGN 1240
Query: 3240 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEEL 3299
+ D ++ ++ I+ R + N++ A + + KF + L W+ E++
Sbjct: 1241 INSD--RIQEKVDSIDDR-HRKNRETASELLMRLKDNRDLQKFLQDCQELSLWI--NEKM 1295
Query: 3300 IANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQ---SAELADREKI 3356
+ Q E + + ++ + + L K +D ++ EG ++ E +EK+
Sbjct: 1296 LTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKL 1355
Query: 3357 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3416
TG L W L S + ++L D A+ F ++ + +L E ++ S+ G
Sbjct: 1356 TG----LHKMWEVLESTTQTKAQRLFD-ANKAELFTQSCADLDKWLHGLESQI-QSDDYG 1409
Query: 3417 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDS----L 3472
+ + + + LE +E ++ + Q+LS ++G ++++DS +
Sbjct: 1410 KDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALS------QEGKSTDEVDSKRLTV 1463
Query: 3473 QARYSEIQDRCC-RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVL 3531
Q ++ E+ + RK LL A F D + + W+ E L++ +
Sbjct: 1464 QTKFMELLEPLNERKHNLL--ASKEIHQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTV 1520
Query: 3532 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVT 3591
+ L +EI + +D + Q ++ ++ I+++L +K + +
Sbjct: 1521 QLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEE 1580
Query: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELK 3651
+ K R LE+A + A ++ E W+ E+EL + EQ ++ ++
Sbjct: 1581 TEKRHRRLEEAHR-AQQYYFDAAEAEAWMS--EQELYMMSEEKAKDEQSAVSMLKKHQIL 1637
Query: 3652 KEVMEHRLVLDTVNEVSRALLELV--PWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 3709
++ +E +TV+++S+ LV E + S ++ Y + D +R ++D
Sbjct: 1638 EQAVED--YAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLD 1695
Query: 3710 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQD-QTTAQLQVQ-KAFSIDIIRHK 3767
+ Q + D E W+AE R+++A G L QD + LQ + + F+ D
Sbjct: 1696 ERHRLFQLNREVDDLE-QWIAE--REVVA-GSHELGQDYEHVTMLQERFREFARDTGNIG 1751
Query: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQF 3827
+ +H ++ G + E + L + + + L R ++ A +++F
Sbjct: 1752 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR-TQILAASYELHKF 1810
Query: 3828 WETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 3887
+ +E+ I++ +LP E+L + Q + L+ H + +G
Sbjct: 1811 YHDAKEIFGRIQDKH---KKLP------EELGRDQNTVETLQRM---HTTFEHDIQALGT 1858
Query: 3888 QLKELNPEEGEMVEEKY--QKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDK---- 3941
Q+++L E+ ++ Y KA+++ + E + LD S+ ++ + DK
Sbjct: 1859 QVRQLQ-EDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFF 1917
Query: 3942 --IEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEE 3999
+ ++ +E++ ++ P +V + +++++ E++ SF G+
Sbjct: 1918 SMVRDLMLWMEDVIRQIEAQEK-PRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKS 1976
Query: 4000 LIGRSQGADKDLAAKEIQ--DKLDQMVFFWED 4029
L+ R A +++ K +Q +K +M+ WED
Sbjct: 1977 LLARKHYASEEIKEKLLQLTEKRKEMIDKWED 2008
Score = 139 bits (350), Expect = 8e-32
Identities = 255/1435 (17%), Positives = 560/1435 (39%), Gaps = 152/1435 (10%)
Query: 3702 GQRVDEI-DAAIQRS---QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK 3757
G+R+ ++ D AI+ ++YE A L W+ +T ++ L + Q Q+Q
Sbjct: 287 GKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQT---IIILNNRKFANSLVGVQQQLQA 343
Query: 3758 AFSIDIIRHKDSMDE-------LFSHRSEIFGTCGEEQKTVLQEKTE---SLIQQYEAIS 3807
+ + E LF+ +S++ QK + + + + + +E +
Sbjct: 344 FNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRAN---NQKVYMPREGKLISDINKAWERLE 400
Query: 3808 LLNSER-------YARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQ 3860
ER R E+ + L +F W+ E + L++Q + D +
Sbjct: 401 KAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQ-DNFGFDLPAVEA 459
Query: 3861 QQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 3920
++ + IA ++ + ++ + +L+ N + + + + ++ + E +R
Sbjct: 460 ATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRA 519
Query: 3921 RA------LALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECIS 3974
R L L + + I ++ D+++ ++ + + L + L+
Sbjct: 520 RRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLL------------ 567
Query: 3975 DNKSATVELEKLQPSFEALKRRGEELIGRSQGAD----KDLAAKEIQDKLDQMVFFWEDI 4030
K VE + +A + RG + D K + I+D++ M F ++++
Sbjct: 568 -QKHTLVEADI---GIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQEL 623
Query: 4031 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4090
A ER + + L + FW +MA I++ + I+ + G D + + + +
Sbjct: 624 CQLAAERRARLEESRRLWKFFW-EMAEEEGWIREKEKILSS-DDYGKDLTSVMRLLSKHR 681
Query: 4091 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4150
++E G E G D+I A ++R+ I + W NL + R ++L
Sbjct: 682 AFEDEMSGRSGHFEQAIKEGEDMI-AEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRL 740
Query: 4151 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQI 4210
E+A Q+Q + W+ + ++K+ + VG D + + + + K+ E+ +
Sbjct: 741 EEA-SLLHQFQADADDIDAWMLD-ILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 798
Query: 4211 EMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270
++ L+ Q + ++ + D +R L+ ++ ++ + E R+ L+ L F
Sbjct: 799 TLDTLHEQASALPQEHAESPD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMF 855
Query: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHV--LKNDVLAHQATVETVNKA 4328
A + W+ E+ L+ + K+ ++E+ +H L+ ++ + V VN+
Sbjct: 856 SEA-DACELWIDEKEQWLNNMQI---PEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQI 911
Query: 4329 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFH---SEIED 4385
+L+ S + ++++ + +N W + + ++ L S L Q +H +E +
Sbjct: 912 ARQLMHSGHPSE-KEIKAQQDKLNTRWSQFRELVDRKKDALLSALS-IQNYHLECNETKS 969
Query: 4386 FLLELTRM-ESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLS 4444
++ E T++ ES G+ R+ +L + ++AK + +K L
Sbjct: 970 WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVA-IEAKLSDLQKEAEK-----LE 1023
Query: 4445 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 4504
+ +A + W + + ++ R++ L EA L +F L +F +WL+ +
Sbjct: 1024 SEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ-QFLRDLDDFQSWLSRTQ 1082
Query: 4505 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIK 4564
++ P+ L + +H+ NE++ + + ++ G + + ++
Sbjct: 1083 TAIASEDMPNT-LTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1141
Query: 4565 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 4624
L ++ + W ++ + E ++L +QF K+ +L + E L + E+
Sbjct: 1142 QRLQALDTGWNEL-HKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-AHTEMPT 1199
Query: 4625 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKW 4684
+ + + K ++F T+ + + + TGR L + D +++K
Sbjct: 1200 TLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSD---------RIQEKV 1250
Query: 4685 DTVCGKSVERQHKLEEALLFSGQFMDALQALVDW----LYKVEPQLAEDQPVHGDLDLVM 4740
D++ + + + E L+ D + L D L+ E L + + +
Sbjct: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1310
Query: 4741 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 4800
+ H+ F EL + +++ G +LI + VK +L L W+ + +
Sbjct: 1311 SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ 1370
Query: 4801 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEA-----LQSLIDTHK 4855
+K RL A K AE+F + L +WL E ++ D T Q +++
Sbjct: 1371 TKAQRLFDANK-AELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQM 1429
Query: 4856 EFMKK-VEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQR 4914
E KK +EE + + G+ + ++ +F E+L + +
Sbjct: 1430 EVRKKEIEELQSQAQALSQEGK---------STDEVDSKRLTVQTKFMELLEPLNERKHN 1480
Query: 4915 LETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTR 4974
L + N ++ +E+L W + N+ V+ LI ++QT +E+
Sbjct: 1481 LLASKEIHQFNRDVEDEIL----WVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQG 1536
Query: 4975 KQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQL 5034
QP +D + + + +NI + S I Q
Sbjct: 1537 HQPRIDDIFE--RSQNI----------------------------VTDSSSLSAEAIRQR 1566
Query: 5035 SARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVM 5089
A +Q+W L +E K + RLEE + FD + WM+ ++ +M
Sbjct: 1567 LADLKQLWGLLIEETEKRH---RRLEEAHRAQQYYFDAAEAE--AWMSEQELYMM 1616
Score = 94.7 bits (234), Expect = 2e-18
Identities = 285/1533 (18%), Positives = 577/1533 (37%), Gaps = 215/1533 (14%)
Query: 592 LLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE-ELGSSVKEARLYEGKMSQNF 650
++ W++EM++ + ++G L VE L+ HT VE ++G + R +Q F
Sbjct: 540 IMDWMDEMKVLVLSQDYGKHLLGVEDLLQK----HTLVEADIGIQAERVRGVNAS-AQKF 594
Query: 651 HTS-----------YAETLGKLETQY---CKLKETSSFRMRHLQSLHKFVSRATAELIWL 696
T + + +E Y C+L R+ + L KF E W+
Sbjct: 595 ATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWI 654
Query: 697 NEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQT 756
EKE+ + D+ + +++ + E+ + F E + E H +
Sbjct: 655 REKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK 714
Query: 757 VEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCD 816
+ ++ Q ++QL ++ ++E + QF +DA ++++++ D +K S D
Sbjct: 715 IRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWML---DILKIVSSSD 771
Query: 817 HNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPD------------ 864
+ L++ D E++ + ++ +L ++ + Q SPD
Sbjct: 772 VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERY 831
Query: 865 -HVLKNT-ISVKAVCDYRQIEITICKNDECVL--EDNSQRTKWKVISPTGNEAMVPSVCF 920
V + T + +A+ D + + D C L ++ Q I + V F
Sbjct: 832 KEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF 891
Query: 921 LIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLIS--------WNYLRKDLDLVQT 972
P + ASRV Q L H H + K + + W+ R+ +D +
Sbjct: 892 ESLEPEMN--NQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKD 949
Query: 973 WNLEKLR-SSAPGECHQIMKNLQAHYE--DFLQDSRDSVLFSVADRLRL---EEEVEACK 1026
L L + EC++ ++ + + QD + + +A + +L E ++ A +
Sbjct: 950 ALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIE 1009
Query: 1027 ARFQHLMKSMEN-EDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRT------ 1079
A+ L K E E + A+ +S L I EE + + R SL +
Sbjct: 1010 AKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLR 1069
Query: 1080 ---DRDAW---QDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF-------------LH 1120
D +W A+ + +T + ++L + + + + D++ +
Sbjct: 1070 DLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVT 1129
Query: 1121 QSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKL 1180
Q + + LR L L + ++ + N L + ++D K E L
Sbjct: 1130 QGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDT----KQAEAFL 1185
Query: 1181 SQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNL 1240
+ +E VLA +TL + +K + + +D K V E RL + N+
Sbjct: 1186 NNQEYVLAHTEMP----TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNI 1241
Query: 1241 DLERYQEKGSQLQERWHR---VIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ 1297
+ +R QEK + +R + ++L +R + +Q+ L D + L WI E
Sbjct: 1242 NSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQE----LSLWINEKMLT 1297
Query: 1298 QEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQY-------STIVKDY 1350
+ M +++R L + + A AE+ N+ LD+ +K Q +VK+
Sbjct: 1298 AQDMS---YDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEK 1354
Query: 1351 ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISD-- 1408
L +ES ++ +R + ++ TQ DL L + Q Y D
Sbjct: 1355 LTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLES-QIQSDDYGKDLT 1413
Query: 1409 ALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQ- 1467
++ L ++++++E + + ++++EL L++ +GK+T + ++ +E
Sbjct: 1414 SVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQ--EGKSTDEVDSKRLTVQTKFMELL 1471
Query: 1468 QVLSEE---LTTKKE--QVSEAIKTSQIFLAK---------HGHKLSE-----KEKKQIS 1508
+ L+E L KE Q + ++ +++ + HGH L K+ + +
Sbjct: 1472 EPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQ 1531
Query: 1509 EQLNALNKAYHDLCDGSAN------------------QLQQLQSQLAHQTEQKTLQKQQN 1550
+++ D+ + S N L+QL L +TE++ + ++
Sbjct: 1532 KEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA 1591
Query: 1551 TCHQQL----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSF 1606
QQ + +W+ + E + + +Q ++ K L+ +D
Sbjct: 1592 HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQL 1651
Query: 1607 ATVVKDIEGFMEENQTKLSPRELTALREKLHQ-----AKEQYEALQEETRVAQKELEEAV 1661
+ + + ++S R+ +KL+ A+E+ L E R+ Q E
Sbjct: 1652 SKTSRALVADSHPESERISMRQSKV--DKLYAGLKDLAEERRGKLDERHRLFQLNREVDD 1709
Query: 1662 TSALQQETEKSKAAKELAENKKKIDALLD----WVTSVGSSGGQLLTNLPGMEQLSGASL 1717
E E + EL ++ + + L + + G+ G + + + + S
Sbjct: 1710 LEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSG 1769
Query: 1718 EKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAF-LDQHGHN 1776
A + G+N+A L E++ R Q L + + + + F Q H
Sbjct: 1770 HSDAATIAEWKDGLNEAWADL---LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHK 1826
Query: 1777 LTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ---------------DELQKFL 1821
PEE Q + L+ ++T +A QV+ LQ D++QK
Sbjct: 1827 KLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQK-- 1884
Query: 1822 QDHKEFESW---LERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI------------ 1866
++++ E+W L+ E + G S+++ + EDVI
Sbjct: 1885 RENEVLEAWKSLLDACESRRVRLVDTGDKFRFF-SMVRDLMLWMEDVIRQIEAQEKPRDV 1943
Query: 1867 --------SHKG---DLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTA 1915
+H+G ++ S +++ S K + +K+KL TE+
Sbjct: 1944 SSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYAS--EEIKEKLLQLTEKRKE 2001
Query: 1916 LHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWM 1948
+ K L ++L + HQF A +AW+
Sbjct: 2002 MIDKWEDRWEWLRLIL-EVHQFSRDASVAEAWL 2033
Score = 53.9 bits (128), Expect = 4e-06
Identities = 74/402 (18%), Positives = 166/402 (41%), Gaps = 49/402 (12%)
Query: 472 DVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTL--------RLEC 523
D+ ++Q+C+ L + + +D +Y + L + ++ Q + L ++E
Sbjct: 1276 DLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEK 1335
Query: 524 TNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDE 583
+ E V LT H E L T + + F +AEL S ++
Sbjct: 1336 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLF--DANKAELFTQSCAD-- 1391
Query: 584 GNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYE 643
L W+ ++ +++ ++G DL SV + L+ QQ + +E ++E +
Sbjct: 1392 --------LDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA 1443
Query: 644 GKMSQNFHTSYAETLGKL--ETQYCKLKETSSFRMRHL---QSLHKFVSRATAELIWLNE 698
+SQ ++ +L +T++ +L E + R +L + +H+F E++W+ E
Sbjct: 1444 QALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGE 1503
Query: 699 KEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQ----DVFRSLQDTAELLSLENHPAK 754
+ + D N + L E++ Q D+F Q+
Sbjct: 1504 RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNI----------VT 1553
Query: 755 QTVEAYSAAVQSQLQWMKQLC-LCVEQ------HVKENTAYFQFFSDARELESFLRNLQ- 806
+ + A++ +L +KQL L +E+ ++E Q++ DA E E+++ +
Sbjct: 1554 DSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQEL 1613
Query: 807 DSIKRKYSCDHNTSLSRLE--DLLQDSMDEKEQLIQSKSSVA 846
+ + + D +++S L+ +L+ ++++ + + S +
Sbjct: 1614 YMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTS 1655
Score = 43.9 bits (102), Expect = 0.004
Identities = 48/248 (19%), Positives = 101/248 (40%), Gaps = 17/248 (6%)
Query: 567 KPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIH 626
+P+ + ++S E R V + + WV E + G++L +V+L ++ Q +
Sbjct: 1472 EPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQ 1531
Query: 627 TSVEELGSSVKEARLYEGKMSQNFHTSYA--------ETLGKLETQYCKLKETSSFRMRH 678
++ G + ++E SQN T + + L L+ + L E + R R
Sbjct: 1532 KEIQ--GHQPRIDDIFE--RSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRR 1587
Query: 679 LQSLHK----FVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQD 734
L+ H+ + A AE W++E+E ++ + + + + + L +E+ +
Sbjct: 1588 LEEAHRAQQYYFDAAEAEA-WMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAE 1646
Query: 735 VFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSD 794
L T+ L ++HP + + + V +K L + E FQ +
Sbjct: 1647 TVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNRE 1706
Query: 795 ARELESFL 802
+LE ++
Sbjct: 1707 VDDLEQWI 1714
Score = 33.5 bits (75), Expect = 5.9
Identities = 50/249 (20%), Positives = 93/249 (37%), Gaps = 34/249 (13%)
Query: 549 KAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRF---VYELLSWVEEMQMKLER 605
KA+ + K + +W + + E + + RF V +L+ W+E++ ++E
Sbjct: 1878 KADDIQKRENEVLEAW-KSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEA 1936
Query: 606 AEWGNDLPSVELQLETQQHIHTSVE----------ELGSSVKEARLYEGKMSQNFHTSYA 655
E D+ SVEL + Q I ++ ELG S+ + Y S+
Sbjct: 1937 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHY---ASEEIKEKLL 1993
Query: 656 ETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKE----EEELAYDWSDN 711
+ K + K ++ + +R + +H+F A+ WL +E E+ D
Sbjct: 1994 QLTEKRKEMIDKWEDRWEW-LRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQS-VDE 2051
Query: 712 NSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENH----------PAKQTVEAYS 761
+ + F + +E+ L T ELL + P+ + S
Sbjct: 2052 VEKLIKRHEAFEKSAATWDERFSALERL-TTLELLEVRRQQEEEERKRRPPSPEPSTKVS 2110
Query: 762 AAVQSQLQW 770
+SQ QW
Sbjct: 2111 EEAESQQQW 2119
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 361 bits (926), Expect = 1e-98
Identities = 425/1740 (24%), Positives = 737/1740 (42%), Gaps = 275/1740 (15%)
Query: 28 SERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKW 87
S SG LSP G +P+N E + ++ QD ER+ VQKKTFTKW
Sbjct: 7 SSISGPLSPAYTGQ-VPYNYNQLEGRFKQLQD---------------EREAVQKKTFTKW 50
Query: 88 VNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPRE-KGRMRFHRLQNVQIALDFL 146
VN HL +V I DLY DLRDG LI LLEVLSG +LP+ KGRMR H L+NV AL FL
Sbjct: 51 VNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFL 110
Query: 147 KQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESG--DMSAKEKLLLWT 204
K+++V L N+ + DI DGN +LTLGLIWTIIL FQI DI + E SAK+ LLLW
Sbjct: 111 KEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWC 170
Query: 205 QKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAER 264
Q TAGY + NF++ W DG FNALIH++RPDL+D ++++ + NL+ AF +AE+
Sbjct: 171 QMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQ 230
Query: 265 -LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPE---GGEGI-----SATEVDSR 315
LG+T+LLD ED+ V PDEKS+ITYV + Y F K+ G+ I +A E +
Sbjct: 231 HLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKM 290
Query: 316 WQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIE 375
++Y+S L+ WI+Q I+++++ F + V ++ + ++ E K EKG +E
Sbjct: 291 IEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLE 350
Query: 376 ELYKLLEVWIEFGRIKL---PQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQI 432
L ++ + K+ +G +D+ + W +L ERE +LR + R E L Q+
Sbjct: 351 VLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQL 410
Query: 433 ANKIQNGALNCEEKLTLAKNTLQAD-------AAHLESGQPVQCESDVIMYIQECEGLIR 485
A + A E L+ + + D A + + E+D+ Y + + ++
Sbjct: 411 ARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVA 470
Query: 486 QLQVDLQILRDENYYQLEELAFR---VMRLQDELVTL------RLECTNLYRKGHFTSLE 536
+ L ENY+ ++ + R V+RL + L+ L RLE NL + F +
Sbjct: 471 VARE----LEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLE-MNLGLQKIFQEML 525
Query: 537 LVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWV 596
+ W E+ + S+D G + L V
Sbjct: 526 YI-----------------------MDWM------DEMKVLVLSQDYG------KHLLGV 550
Query: 597 EEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAE 656
E++ K E + +Q E + ++ S ++ + + + + ++ + +
Sbjct: 551 EDLLQKHTLVE-----ADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIR-------D 598
Query: 657 TLGKLETQY---CKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNS 713
+ +E Y C+L R+ + L KF E W+ EKE+ + D+ + +
Sbjct: 599 RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLT 658
Query: 714 NISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQ 773
++ + E+ + F E + E H + + ++ Q ++Q
Sbjct: 659 SVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQ 718
Query: 774 LCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMD 833
L ++ ++E + QF +DA +++++ + D +K S D + L++ D
Sbjct: 719 LSAIRKKRLEEASLLHQFQADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKD 775
Query: 834 EKEQLIQSKSSVASLVGRSKTIVQLKPRSPD-------------HVLKNT-ISVKAVCDY 879
E++ + ++ +L ++ + Q SPD V + T + +A+ D
Sbjct: 776 VAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDT 835
Query: 880 RQIEITICKNDECVL--EDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVE 937
+ + D C L ++ Q I + V F P + ASRV
Sbjct: 836 LALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMN--NQASRVA 893
Query: 938 QSYQKVMALWHQLHVNTKSL--------ISWNYLRKDLDLVQTWNLEKLR-SSAPGECHQ 988
Q L H H + K + W+ R+ +D + L L + EC++
Sbjct: 894 VVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNE 953
Query: 989 IMKNLQAHYE--DFLQDSRDSVLFSVADRLRL---EEEVEACKARFQHLMKSMEN-EDKE 1042
++ + + QD + + +A + +L E ++ A +A+ L K E E +
Sbjct: 954 TKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEH 1013
Query: 1043 ETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSR---------TDRDAW---QDNALR 1090
A+ +S L I EE + + R SL + D +W A+
Sbjct: 1014 PDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA 1073
Query: 1091 IAEQEHTQEDLQQLRSDLDAVSMKCDSF-------------LHQSPSSSSVPTLRSELNL 1137
+ +T + ++L + + + + D++ + Q + + LR L
Sbjct: 1074 SEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQA 1133
Query: 1138 LVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHW 1197
L + ++ + N L + ++D K E L+ +E VLA
Sbjct: 1134 LDTGWNELHKMWENRQNLLSQSHAYQQFLRD----TKQAEAFLNNQEYVLAHTEMP---- 1185
Query: 1198 STLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWH 1257
+TL + +K + + +D K V E RL + N++ +R QEK + +R H
Sbjct: 1186 TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDR-H 1244
Query: 1258 R----VIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLS 1313
R ++L +R + +Q+ L D + L WI E + M +++R L
Sbjct: 1245 RKNRETASELLMRLKDNRDLQKFLQDCQ----ELSLWINEKMLTAQDM---SYDEARNLH 1297
Query: 1314 EQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRR 1373
+ + A AE+ N+ LD+ +K +QL++ K E+
Sbjct: 1298 SKWLKHQAFMAELASNKEWLDKIEKEG-----------MQLISEKPETEA---------- 1336
Query: 1374 MLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKE 1433
+ ++ L + L + T + + DA + + + +
Sbjct: 1337 ------VVKEKLTGLHKMWEVLESTTQTKAQRLFDA------------NKAELFTQSCAD 1378
Query: 1434 LLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLA 1493
L W+ L Q + K+ T + + +QQ+L ++ +K+++ E +Q L+
Sbjct: 1379 LDKWLHGLESQIQ---SDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQA-LS 1434
Query: 1494 KHGHKLSEKEKKQIS------EQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQK 1547
+ G E + K+++ E L LN+ H+L L S+ HQ
Sbjct: 1435 QEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNL----------LASKEIHQ-------- 1476
Query: 1548 QQNTCHQQLEDLCSWVGQ-AERALAGHQGRTTQQDLSALQKNQSDLKDLQ------DDIQ 1600
++ +ED WVG+ A + G Q ++KNQ+ K++Q DDI
Sbjct: 1477 ----FNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIF 1532
Query: 1601 NRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEA 1660
R+ + T + + LS A+R++L K+ + L EET + LEEA
Sbjct: 1533 ERSQNIVT-----------DSSSLSAE---AIRQRLADLKQLWGLLIEETEKRHRRLEEA 1578
Score = 201 bits (511), Expect = 2e-50
Identities = 326/1644 (19%), Positives = 687/1644 (41%), Gaps = 106/1644 (6%)
Query: 3249 HDMEEINAR-------WNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIA 3301
HD++ I AR W L + + R +L+ L FQ+ L ++ W+ + + L+
Sbjct: 481 HDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVL 539
Query: 3302 NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAE---LADREKITG 3358
+Q V+ +Q+ L++ + + V + A + A E D + I
Sbjct: 540 SQDY-GKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRD 598
Query: 3359 QLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQ 3418
++ +E + EL AA R+ +LE+ L K F E AE + ++K+ +S+ G
Sbjct: 599 RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAE--EEGWIREKEKILSSDDYGKD 656
Query: 3419 TAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDS----LQA 3474
+ + + +H+A E+++ + QA+K G+ + AE+ SEKI ++
Sbjct: 657 LTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMI-----AEEHFGSEKIRERIIYIRE 711
Query: 3475 RYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFV--KDFKQDVLH 3532
+++ ++ + L++A S F D ++ W+ ++ +SS V ++ L
Sbjct: 712 QWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLV 770
Query: 3533 RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTS 3592
++H D + EEI N + +D + AL ++ E ++ +L GI+ RY ++ +
Sbjct: 771 KKHKD---VAEEIANYRPTLDTLHEQASALPQEHA--ESPDVRGRLSGIEERYKEVAELT 825
Query: 3593 SKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTG-EQIPQFQQRQKELK 3651
+ L+ L F S + W+ E E+ L + Q P E + Q R + L+
Sbjct: 826 RLRKQALQDTLALYKMF-SEADACELWIDEKEQWL--NNMQIPEKLEDLEVIQHRFESLE 882
Query: 3652 KEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAA 3711
E+ + VN+++R L+ +E + N ++ + + ++ D + +A
Sbjct: 883 PEMNNQASRVAVVNQIARQLMHSGHPSEKE-IKAQQDKLNTRWSQFRELVDRKKDALLSA 941
Query: 3712 IQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMD 3771
+ Q Y + +W+ E + + + + + A + D++ + +
Sbjct: 942 LS-IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLS 1000
Query: 3772 ELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 3831
+L ++ ++ + +L E + +E + R A L A L QF
Sbjct: 1001 DLQKEAEKLESEHPDQAQAILSRLAE-ISDVWEEMKTTLKNREASLGEASKL-QQFLRDL 1058
Query: 3832 EELSPWIEETRALIAQ--LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL 3889
++ W+ T+ IA +P+ + E+L Q E ++ I ++ K+ +G +
Sbjct: 1059 DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHEN---IKNEIDNYEEDYQKMRDMGEMV 1115
Query: 3890 KELNPEEGEM-VEEKYQKAENMYAQIKE--EVRQRALALDEAVSQSTQITEFHDKIEPML 3946
+ + M + ++ Q + + ++ + E RQ L+ A Q + T+ + E L
Sbjct: 1116 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTK---QAEAFL 1172
Query: 3947 ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4006
E + + MP + + I + ++ + A+ G L+
Sbjct: 1173 NNQEYVLAHTEMPTTL----EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLV----- 1223
Query: 4007 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD-- 4064
+D ++ + IQ+K+D + + A E ++ D +L +KF D L I +
Sbjct: 1224 SDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWINEKM 1282
Query: 4065 --TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEK 4122
QD+ +D E+ + +K Q AE + E L+ I G LI ETE
Sbjct: 1283 LTAQDMSYD-EARNLHSKWLKHQAFMAELASNK-----EWLDKIEKEGMQLISEKPETEA 1336
Query: 4123 PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP 4182
V++ + ++ WE L T + + ++L DA +A + + + + WL ++ +
Sbjct: 1337 V-VKEKLTGLHKMWEVLESTTQTKAQRLFDANKAEL-FTQSCADLDKWLHGLESQIQS-D 1393
Query: 4183 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK--KATDETDRDIIREPLT 4240
G DL +V L + + + ++ ++ E+E+L Q + + + K+TDE D + T
Sbjct: 1394 DYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQ-T 1452
Query: 4241 ELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKV 4300
+ L E L E R+H L A + QF +E+ + W+ L + + +
Sbjct: 1453 KFMELLEPLNE----RKHNLL-ASKEIHQFNRDVEDEILWVGERMPLATSTDH-GHNLQT 1506
Query: 4301 IEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQ 4360
+++ + K+ L+ ++ HQ ++ + + ++ S+ A ++R RL + Q W +++
Sbjct: 1507 VQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIE 1566
Query: 4361 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMEL 4420
+TE+R ++L+ +AQ ++ + + ++ E + + + ++A L H L
Sbjct: 1567 ETEKRHRRLEEA-HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-EQSAVSMLKKHQIL 1624
Query: 4421 YSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4480
++ ET +QL R ++ D + + +++ + + EER+ KL+
Sbjct: 1625 EQAVEDYAETVHQLSKTSRALV--ADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLD 1682
Query: 4481 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEV-NAHRD 4539
E L + + + W+ E + + Q E + FA + N ++
Sbjct: 1683 ERHRL-FQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQ-ERFREFARDTGNIGQE 1740
Query: 4540 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFH 4599
++ ++ ++L S D I + W +++ R + L + + K +H
Sbjct: 1741 RVDTVNHLADEL-INSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYH 1799
Query: 4600 EAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQ---KTLGGK-QPVYDTTIR 4655
+A K++ ++D L EL D + ++ H F+ + LG + + + + R
Sbjct: 1800 DA-KEIFGRIQDKHKKLPEEL--GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAAR 1856
Query: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
A +D QK +N EV + W ++ R+ +L + +F ++ L
Sbjct: 1857 LQAAYAGDK--ADDIQKREN---EVLEAWKSLLDACESRRVRLVDT-GDKFRFFSMVRDL 1910
Query: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775
+ W+ V Q+ E Q D+ V LM+ H+ + E+ R + G+ L+
Sbjct: 1911 MLWMEDVIRQI-EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKH 1969
Query: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 4835
+ +K +L +L+ + + + L L+ + RD + WL E L
Sbjct: 1970 YASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRD-ASVAEAWLLGQEPYLS 2028
Query: 4836 FRGALPDDTEALQSLIDTHKEFMK 4859
R + + ++ LI H+ F K
Sbjct: 2029 SR-EIGQSVDEVEKLIKRHEAFEK 2051
Score = 171 bits (434), Expect = 1e-41
Identities = 326/1760 (18%), Positives = 699/1760 (39%), Gaps = 173/1760 (9%)
Query: 3281 KFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATV------ 3334
K++ LL W+ T ++ N+K ++ V + Q+Q + + K T
Sbjct: 293 KYESLASDLLEWIEQTIIILNNRKFANSLVGV-QQQLQAFNTYRTVEKPPKFTEKGNLEV 351
Query: 3335 ------DMLQAEGGRIAQSAE---LADREKITGQLESLESRWTELLSKAAARQKQLEDIL 3385
++A ++ E ++D K +LE E L RQ++LE
Sbjct: 352 LLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQ-- 409
Query: 3386 VLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3445
LA++F A +LS ++ L + + G ++ +H+A+E DI + V
Sbjct: 410 -LARRFDRKAAMRETWLSENQR-LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQA 467
Query: 3446 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 3505
V + + L + + + + K D++ + + + + L+ L ++F ++ +
Sbjct: 468 VVAVARELEAENYHDIKRITARK-DNVIRLWEYLLELLRARRQRLEMNLGLQKIF-QEML 525
Query: 3506 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK-------- 3557
+++W+ E+ K VL + + HL E+++ + V+ I
Sbjct: 526 YIMDWMDEM------------KVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRG 573
Query: 3558 -NGQALLKQTTGE-----EVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQS 3611
N A T GE + +I++++ ++ Y ++ +++ LE++R+L F
Sbjct: 574 VNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWE 633
Query: 3612 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL 3671
EE GW+RE E+ L++ + + + + + +HR D ++ S
Sbjct: 634 MAEE-EGWIREKEKILSSD-----------DYGKDLTSVMRLLSKHRAFEDEMSGRSGHF 681
Query: 3672 LELVPWRAREGLDKLVSD-------------ANEQYKLVSDTIGQRVDEIDAAIQRSQQY 3718
+ + +EG D + + EQ+ + R ++ A Q+
Sbjct: 682 EQAI----KEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA-SLLHQF 736
Query: 3719 EQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRS 3778
+ AD AW+ + L + + D+ + Q V+K HKD +E+ ++R
Sbjct: 737 QADADDIDAWMLDI---LKIVSSSDVGHDEYSTQSLVKK--------HKDVAEEIANYRP 785
Query: 3779 EIFGTCGEEQKTVLQEKTES---------LIQQYEAISLLNSERYARLERAQVLVNQFWE 3829
+ T E+ + QE ES + ++Y+ ++ L R L+ L F E
Sbjct: 786 TL-DTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 844
Query: 3830 TYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL 3889
+ WI+E + + P E L Q L + + + +I QL
Sbjct: 845 A-DACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQL 902
Query: 3890 KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 3949
+ ++ + K ++Q +E V ++ AL A+S E ++ + E
Sbjct: 903 MHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKT 962
Query: 3950 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4009
+ + S + + + R+ + +L ++ L++ E+L S+ D+
Sbjct: 963 KVIESTQDLGNDLAGVMALQRKLTGMER----DLVAIEAKLSDLQKEAEKL--ESEHPDQ 1016
Query: 4010 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4069
A+ I +L ++ WE++K + RE + +L ++F D+ + + TQ +
Sbjct: 1017 ---AQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQTAI 1072
Query: 4070 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4129
+ P K + E IK E D E+ + +R +G + + + +R+ +
Sbjct: 1073 ASEDMPNTLTEAEKLLTQH-ENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRL 1131
Query: 4130 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNT--VIKLCTMPPVGTD 4187
++ W L+K W+ R L + +DT QA +L+N V+ MP T
Sbjct: 1132 QALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEA-FLNNQEYVLAHTEMP---TT 1187
Query: 4188 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4247
L + + + ++F + + ++ + G ++ +DR I+E + +
Sbjct: 1188 LEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDR--IQEKVDSIDDRHR 1245
Query: 4248 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAK 4307
E + +L+ L +F +EL W+ E++L AQ + + + + K
Sbjct: 1246 KNRETASELLMRLKDNR-DLQKFLQDCQELSLWIN--EKMLTAQDMSYDEARNLHSKWLK 1302
Query: 4308 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQ 4367
H ++ +++ ++ + K G +L+ +A ++ +L +++ WE VL+ T + +
Sbjct: 1303 HQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV-VKEKLTGLHKMWE-VLESTTQTKA 1360
Query: 4368 QLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAK 4427
Q +A+ F D L +ESQ+ S G + L L +Q++ +
Sbjct: 1361 QRLFDANKAELFTQSCADLDKWLHGLESQIQ-SDDYGKDLTSVNILLKKQQMLENQMEVR 1419
Query: 4428 EETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLAT 4487
++ +L + + + + S + + ++ K+ + + ERK L + +
Sbjct: 1420 KKEIEELQSQAQAL---SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIH- 1475
Query: 4488 EFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQT 4547
+F +++ I W+ L ++ L TV I++++ E+ H+ +I ++ +
Sbjct: 1476 QFNRDVEDEILWVG-ERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFER 1534
Query: 4548 GNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLID 4607
+ S I+ L ++ W +++ + +R R L++A RA+Q++ +
Sbjct: 1535 SQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAH-RAQQYYFDAAEAEA 1593
Query: 4608 WLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL-----KE 4662
W+ + E ++ SE + ++ + + L KH+ ++ + +T RAL E
Sbjct: 1594 WMSEQELYMMSEEKAKDEQSAVSM-LKKHQILEQAVEDYAETVHQLSKTSRALVADSHPE 1652
Query: 4663 KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKV 4722
+ K+D ++D + GK ER H+L Q + L W+ +
Sbjct: 1653 SERISMRQSKVDKLYAGLKDLAEERRGKLDER-HRLF-------QLNREVDDLEQWIAER 1704
Query: 4723 EPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG----KRTGTVQVLKRSGRELIENSRDDT 4778
E +A + D + V L + + F ++ G +R TV L ELI + D
Sbjct: 1705 EV-VAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHL---ADELINSGHSDA 1760
Query: 4779 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 4838
+ L+ W + +L ++ L + + + + D + + ++ G
Sbjct: 1761 ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELG 1820
Query: 4839 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIR 4898
+ E LQ + T + ++ + + + A + A D I +
Sbjct: 1821 RDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDI----------Q 1870
Query: 4899 ARFEEVLTWAKQHQQRLETALSELVANAE------LLEELLAWIQWAETTLIQRDQEPIP 4952
R EVL K E+ LV + ++ +L+ W+ E + Q + + P
Sbjct: 1871 KRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWM---EDVIRQIEAQEKP 1927
Query: 4953 QNIDRVKALIAEHQTFMEEM 4972
+++ V+ L+ HQ E+
Sbjct: 1928 RDVSSVELLMNNHQGIKAEI 1947
Score = 162 bits (409), Expect = 1e-38
Identities = 282/1473 (19%), Positives = 612/1473 (41%), Gaps = 97/1473 (6%)
Query: 3254 INARWNTLNKKVAQRIAQLQEA-LLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV 3312
I +W L + A R +L+EA LLH +FQ + + +W+ D +++++ EY
Sbjct: 709 IREQWANLEQLSAIRKKRLEEASLLH--QFQADADDIDAWMLDILKIVSSSDVGHDEYST 766
Query: 3313 VKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLS 3372
++ +++ K + + + + T+D L + + Q E A+ + G+L +E R+ E+
Sbjct: 767 -QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ--EHAESPDVRGRLSGIEERYKEVAE 823
Query: 3373 KAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSE-PVGTQTAKIQQQIIRHKA 3431
R++ L+D L L K F E A+ ++ E+ L N + P + ++ Q R ++
Sbjct: 824 LTRLRKQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQH--RFES 880
Query: 3432 LEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLD 3491
LE ++ N A+ V +I + L P+E+ + +++ D L R+S+ ++ RK L
Sbjct: 881 LEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ-DKLNTRWSQFRELVDRKKDALL 939
Query: 3492 QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDV---------LHRQHADHLALN 3542
ALS E E +W+ E + S +D D+ L D +A+
Sbjct: 940 SALSIQNYHLECN-ETKSWIREKTKVIEST--QDLGNDLAGVMALQRKLTGMERDLVAIE 996
Query: 3543 EEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQA 3602
++ + +K ++ L+ ++ I +L I + ++ T +L +A
Sbjct: 997 AKLSDLQKEAEK--------LESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEA 1048
Query: 3603 RQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQ---IPQFQQRQKELKKEVMEHRL 3659
+L +F ++ WL + +A+ + E + Q + + E+ +++
Sbjct: 1049 SKLQ-QFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQK 1107
Query: 3660 VLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE 3719
+ D V++ + R+ L L + NE +K+ + Q + A Q+ +
Sbjct: 1108 MRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENR--QNLLSQSHAYQQFLRDT 1165
Query: 3720 QAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSE 3779
+ A+A L + ++A + + A ++ Q+ F + +++ ++ +
Sbjct: 1166 KQAEAFL----NNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRR 1221
Query: 3780 IFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIE 3839
+ G +QEK +S+ ++ SE RL+ + L +F + +ELS WI
Sbjct: 1222 LVSD-GNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWIN 1279
Query: 3840 ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM 3899
E + L AQ S + L + + + +A +K +DK+ K G QL PE +
Sbjct: 1280 E-KMLTAQDMSYD-EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV 1337
Query: 3900 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 3959
V+EK M+ ++ + +A L +A +++ T+ ++ L LE+
Sbjct: 1338 VKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDKWLHGLES-------- 1388
Query: 3960 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD-LAAKEIQD 4018
+ D + ++ + + L+ E K+ EEL ++Q ++ + E+
Sbjct: 1389 ---QIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDS 1445
Query: 4019 KLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGID 4078
K + + ++ ER+ L E+ +F D+ + + + + + G +
Sbjct: 1446 KRLTVQTKFMELLEPLNERKHNLLASKEI-HQFNRDVEDEILWVGERMPLATSTDH-GHN 1503
Query: 4079 PSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWEN 4138
++ ++ +T+++E G ++ I +++ +R+ + ++ W
Sbjct: 1504 LQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL 1563
Query: 4139 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKD-QLNE 4197
L + ++R +LE+A +A Y D +A W+ + + + + + V + ++
Sbjct: 1564 LIEETEKRHRRLEEAHRAQQYYFDAAEAEA-WMSEQELYMMSEEKAKDEQSAVSMLKKHQ 1622
Query: 4198 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4257
+ E VE Y + + +L+ ++ + E++R +R+ +++ L+ L + R+
Sbjct: 1623 ILEQAVEDYAETVH--QLSKTSRALVADSHPESERISMRQ--SKVDKLYAGLKDLAEERR 1678
Query: 4258 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA 4317
KL+ L Q +++L W+ E + + V ++ ++
Sbjct: 1679 GKLDERH-RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI 1737
Query: 4318 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4377
Q V+TVN +EL+ +S DA+++ + +N+ W +L+ + R Q L ++ + +
Sbjct: 1738 GQERVDTVNHLADELI-NSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHK 1796
Query: 4378 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT-HMELYSQLKAKEETYNQLL- 4435
+H E F R++ + G + E L H ++A QL
Sbjct: 1797 FYHDAKEIF----GRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQE 1852
Query: 4436 DKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQE 4495
D RL D + ++ L + W + E R+ +L + + F + +++
Sbjct: 1853 DAARLQAAYAGDKADDIQKRENEVL--EAWKSLLDACESRRVRLVDTGD-KFRFFSMVRD 1909
Query: 4496 FINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS 4555
+ W+ + + P + + L + H+ E++A D + G L L+
Sbjct: 1910 LMLWMEDVIRQIEAQEKPRDVSSVELL-MNNHQGIKAEIDARNDSFTTCIELGKSL--LA 1966
Query: 4556 QKQDVVL-IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAES 4614
+K IK L+ + + ++++ + +R L + QF WL E
Sbjct: 1967 RKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILE-VHQFSRDASVAEAWLLGQEP 2025
Query: 4615 HLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYD-----TTI--------RTGRALK 4661
+L S EI D+++ + +H+ F+K+ + TT+ + K
Sbjct: 2026 YLSSR-EIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERK 2084
Query: 4662 EKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
+ PE S K+ E + +WDT G+ V +
Sbjct: 2085 RRPPSPEPSTKVSE-EAESQQQWDTSKGEQVSQ 2116
Score = 154 bits (389), Expect = 2e-36
Identities = 310/1641 (18%), Positives = 660/1641 (40%), Gaps = 214/1641 (13%)
Query: 1596 QDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQK 1655
Q+ ++ A F E ++ ENQ +S + A +++EA++ + ++
Sbjct: 404 QEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEE 463
Query: 1656 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 1715
++ V A + E E K + K + L +++ + + Q L G++++
Sbjct: 464 RVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQE 523
Query: 1716 SL-------EKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQA 1768
L E L + Y E L ++ +++A ++ Q + SAQ
Sbjct: 524 MLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEA---DIGIQAERVRGVNASAQK 580
Query: 1769 FLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFE 1828
F G P + Q+++ ++ ++ Y L Q AE + L KF + E E
Sbjct: 581 FATD-GEGYKPCDPQVIRDRVAHMEFCYQ-ELCQLAAERRARLEESRRLWKFFWEMAEEE 638
Query: 1829 SWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENS 1888
W+ EK L + G ++ LL + +F +++ G E +
Sbjct: 639 GWIREKEKILSS-DDYGKDLTSVMRLLSKHRAFEDEMSGRSG-------------HFEQA 684
Query: 1889 FKEGKEPSEIGNLVKDKLKDA----------TERYTALHSKCTRLGSHLNMLLGQYHQFQ 1938
KEG++ + +K+++ E+ +A+ K S L HQFQ
Sbjct: 685 IKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLL-------HQFQ 737
Query: 1939 NSADSLQAWMQACEANVEKLLSDT-VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKV 1997
AD + AWM ++ K++S + V D Q + K + EE+A ++ ++ L +
Sbjct: 738 ADADDIDAWM----LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQ 793
Query: 1998 ARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESL 2057
A + + E +PD V+ I ++ ++ R LQ +A + E+ ++
Sbjct: 794 ASALPQEHAE-SPD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEA-DAC 848
Query: 2058 LQSIGEVEQNLEGKQVSSLSSG--VIQEALATNMKLKQDIARQKSSLEATREMVTRFMET 2115
I E EQ L Q+ VIQ + L+ ++ Q S + ++ + M +
Sbjct: 849 ELWIDEKEQWLNNMQIPEKLEDLEVIQHRFES---LEPEMNNQASRVAVVNQIARQLMHS 905
Query: 2116 ADSTTAAV--LQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENK 2173
+ + Q KL +F +L ++K++ L L Q E + + ++ K
Sbjct: 906 GHPSEKEIKAQQDKLNTRWSQFRELV--DRKKDALLSALSIQNYHLE--CNETKSWIREK 961
Query: 2174 SRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDR 2233
++++ S QD+ + + L ++ + +L +E +++L L+ +H D+
Sbjct: 962 TKVIES----TQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLE-SEHPDQ 1016
Query: 2234 VQ-------NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT 2286
Q + + E++ T+K RE +L +F + + FQ WL T+ +I
Sbjct: 1017 AQAILSRLAEISDVWEEMKTTLKNREASLGEA-SKLQQFLRDLDDFQSWLSRTQTAIASE 1075
Query: 2287 ETSMSAKELEK---QIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG 2343
+ + E EK Q E++K+ +D++ EE K + ++ +QG+T
Sbjct: 1076 DMPNTLTEAEKLLTQHENIKNEIDNY-------EEDYQKMRDMGEMV-------TQGQTD 1121
Query: 2344 SILPSVGSSVGSVN-GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEE 2402
+ + + +++ G++ + E + ++ + Y++ L + +++ +A LN E
Sbjct: 1122 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQF---LRDTKQA-EAFLNNQEY 1177
Query: 2403 V--HKEANSVLQWLES----KEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK 2456
V H E + L+ E+ +E+ + +MDA E + A E+ + +++ NS +
Sbjct: 1178 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDA-----NEEKINAVVETGRRLVSDGNINSDR 1232
Query: 2457 IQ-----------KVKEALAGLLVTYPNSQEAENWKKIQEEL----NSRWERATEVTVAR 2501
IQ K +E + LL+ ++++ + + + +EL N + A +++
Sbjct: 1233 IQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDE 1292
Query: 2502 QRQLEESASHLACFQAAESQLRPWL--MEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKE 2559
R L F A + + WL +EKE M L ++K + + ++KE
Sbjct: 1293 ARNLHSKWLKHQAFMAELASNKEWLDKIEKEGM------------QLISEKPETEAVVKE 1340
Query: 2560 -FEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ 2618
+ E L Q D + + + Q +L L+ SQI
Sbjct: 1341 KLTGLHKMWEVLESTTQTKAQRLFDAN--------KAELFTQSCADLDKWLHGLESQIQS 1392
Query: 2619 AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 2678
D + + +V L Q + Q E K+++E E++S + L E
Sbjct: 1393 ------------DDYGKDLTSVNILLKKQQMLENQMEVRKKEIE---ELQSQAQALSQEG 1437
Query: 2679 KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 2738
K DE+ KRL ++ LE L + N L A QF +
Sbjct: 1438 KST----DEVD------------SKRLTVQTKFMELLEPLNERKHNLL--ASKEIHQFNR 1479
Query: 2739 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 2798
++ W+ ++ A + L+ +Q +++N+ QK + H + I +++
Sbjct: 1480 DVEDEILWVGERM-PLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNI 1538
Query: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858
+ ++ +L +LK W L ++T R RL++ +AQ+Y + + W+
Sbjct: 1539 VTD-SSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA-HRAQQYYFDAAEAEAWMS 1596
Query: 2859 DCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI 2918
+ + M D S L + + + VE + L+ + L+ S + + I
Sbjct: 1597 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1656
Query: 2919 RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG 2978
++ +++ + + + + G L+E R R FQ + ++V+ + + + +
Sbjct: 1657 SMRQSKVDKLYAGLKDLAEERRGKLDE---RHRLFQ-----LNREVDDLEQWIAEREVVA 1708
Query: 2979 SQACSNKNLEKLRAQQEVLQAL--------EPQVDYLRNFTQGLVEDAPDGSDASQLLHQ 3030
++ E + QE + + +VD + + L+ SDA+ +
Sbjct: 1709 GSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSG--HSDAATIAEW 1766
Query: 3031 AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT 3090
+ + + ++ + +++ ++ E + +F+ +E+F ++ D +L +GRD
Sbjct: 1767 KDGLNEAWADLLELIDTRTQILAASYE-LHKFYHDAKEIFGRIQDKHKKLP--EELGRDQ 1823
Query: 3091 DSLQSQIEDVRLFLNKIH-VLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGK 3149
+++++ L ++H + DI+A + R + E+ L + + + K+ +
Sbjct: 1824 NTVET--------LQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENE 1875
Query: 3150 LTERGKARQEQLELTLGRVED 3170
+ E K+ + E R+ D
Sbjct: 1876 VLEAWKSLLDACESRRVRLVD 1896
Score = 147 bits (371), Expect = 3e-34
Identities = 312/1712 (18%), Positives = 703/1712 (41%), Gaps = 146/1712 (8%)
Query: 2372 MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2431
+SD+N +E+L HER+ +L+ L R E++ + A + +E L + S
Sbjct: 376 ISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQD 435
Query: 2432 K----TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKI---- 2483
V+A + ++A ++ ++Q V V EAEN+ I
Sbjct: 436 NFGFDLPAVEAATKKHEAIETDIAAYEERVQAV--------VAVARELEAENYHDIKRIT 487
Query: 2484 --QEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 2541
++ + WE E+ AR+++LE + FQ + W+ E ++++ LS
Sbjct: 488 ARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEM-LYIMDWMDEMKVLV-----LSQ 541
Query: 2542 D--PNMLNAQKQQVQFMLKEFE--ARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQ 2596
D ++L + + L E + + ++ +N +AQ T G G ++ +
Sbjct: 542 DYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVA 601
Query: 2597 SINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSA------I 2650
+ + EL R +++++ S + + +++E+ + ++ + S+ +
Sbjct: 602 HMEFCYQELCQLAAERRARLEE----SRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDL 657
Query: 2651 STQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVAL 2710
++ + + E+ + +KE + + E E + +++++R+ +
Sbjct: 658 TSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAE------EHFGSEKIRERIIYIRE 711
Query: 2711 PLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 2770
LE L+A R RL+ A + QFQ D++ W+ D + + + QS
Sbjct: 712 QWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLD-ILKIVSSSDVGHDEYSTQSL 769
Query: 2771 LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGE--EKRTLQNQLVELKNHWEELSKK 2828
++++++ + + + + + + + +L P E E ++ +L ++ ++E+++
Sbjct: 770 VKKHKDVAEEIANYRPTLDTLHEQASAL-----PQEHAESPDVRGRLSGIEERYKEVAEL 824
Query: 2829 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 2888
T R+ L+D + + + + WI++ + ++ +++ LE R +++
Sbjct: 825 TRLRKQALQDTLALYKMFS-EADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEP 883
Query: 2889 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQ 2948
E+ + S + ++N A L++S E I+ ++ +N E + K +L
Sbjct: 884 EMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALS 943
Query: 2949 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE-KLRAQQEVLQALEPQVDYL 3007
++ + + + +E LG+ L+ KL + L A+E ++ L
Sbjct: 944 -IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL 1002
Query: 3008 RNFTQGLVEDAPDGSDA--SQLLHQAEVAQQEFLEVKQRVNS--GCVMMENKLEGIGQFH 3063
+ + L + PD + A S+L ++V ++ +K R S ++ L + F
Sbjct: 1003 QKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQ 1062
Query: 3064 CRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRH 3123
+ + +A D M + + L +Q E+++ N+I + D +
Sbjct: 1063 SWLSRTQTAIASED-----MPNTLTEAEKLLTQHENIK---NEIDNYEEDYQKMRDMGEM 1114
Query: 3124 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG----LN 3179
+ + + + L++ L+AL+ +L + + RQ L + + F R K LN
Sbjct: 1115 VTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQS-HAYQQFLRDTKQAEAFLN 1173
Query: 3180 DATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAG 3239
+ E + G E I Q+ DF +D + K+ V G+ L+
Sbjct: 1174 NQEYVLAHTEMPTTLEGAEAAIKKQE--DF----MTTMDANEEKINAVVETGRRLVSDGN 1227
Query: 3240 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEEL 3299
+ D ++ ++ I+ R + N++ A + + KF + L W+ E++
Sbjct: 1228 INSD--RIQEKVDSIDDR-HRKNRETASELLMRLKDNRDLQKFLQDCQELSLWI--NEKM 1282
Query: 3300 IANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQ---SAELADREKI 3356
+ Q E + + ++ + + L K +D ++ EG ++ E +EK+
Sbjct: 1283 LTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKL 1342
Query: 3357 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3416
TG L W L S + ++L D A+ F ++ + +L E ++ S+ G
Sbjct: 1343 TG----LHKMWEVLESTTQTKAQRLFD-ANKAELFTQSCADLDKWLHGLESQI-QSDDYG 1396
Query: 3417 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDS----L 3472
+ + + + LE +E ++ + Q+LS ++G ++++DS +
Sbjct: 1397 KDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALS------QEGKSTDEVDSKRLTV 1450
Query: 3473 QARYSEIQDRCC-RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVL 3531
Q ++ E+ + RK LL A F D + + W+ E L++ +
Sbjct: 1451 QTKFMELLEPLNERKHNLL--ASKEIHQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTV 1507
Query: 3532 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVT 3591
+ L +EI + +D + Q ++ ++ I+++L +K + +
Sbjct: 1508 QLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEE 1567
Query: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELK 3651
+ K R LE+A + A ++ E W+ E+EL + EQ ++ ++
Sbjct: 1568 TEKRHRRLEEAHR-AQQYYFDAAEAEAWMS--EQELYMMSEEKAKDEQSAVSMLKKHQIL 1624
Query: 3652 KEVMEHRLVLDTVNEVSRALLELV--PWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 3709
++ +E +TV+++S+ LV E + S ++ Y + D +R ++D
Sbjct: 1625 EQAVED--YAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLD 1682
Query: 3710 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQD-QTTAQLQVQ-KAFSIDIIRHK 3767
+ Q + D E W+AE R+++A G L QD + LQ + + F+ D
Sbjct: 1683 ERHRLFQLNREVDDLE-QWIAE--REVVA-GSHELGQDYEHVTMLQERFREFARDTGNIG 1738
Query: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQF 3827
+ +H ++ G + E + L + + + L R ++ A +++F
Sbjct: 1739 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR-TQILAASYELHKF 1797
Query: 3828 WETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 3887
+ +E+ I++ +LP E+L + Q + L+ H + +G
Sbjct: 1798 YHDAKEIFGRIQDKH---KKLP------EELGRDQNTVETLQRM---HTTFEHDIQALGT 1845
Query: 3888 QLKELNPEEGEMVEEKY--QKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDK---- 3941
Q+++L E+ ++ Y KA+++ + E + LD S+ ++ + DK
Sbjct: 1846 QVRQLQ-EDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFF 1904
Query: 3942 --IEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEE 3999
+ ++ +E++ ++ P +V + +++++ E++ SF G+
Sbjct: 1905 SMVRDLMLWMEDVIRQIEAQEK-PRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKS 1963
Query: 4000 LIGRSQGADKDLAAKEIQ--DKLDQMVFFWED 4029
L+ R A +++ K +Q +K +M+ WED
Sbjct: 1964 LLARKHYASEEIKEKLLQLTEKRKEMIDKWED 1995
Score = 139 bits (350), Expect = 8e-32
Identities = 255/1435 (17%), Positives = 560/1435 (39%), Gaps = 152/1435 (10%)
Query: 3702 GQRVDEI-DAAIQRS---QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK 3757
G+R+ ++ D AI+ ++YE A L W+ +T ++ L + Q Q+Q
Sbjct: 274 GKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQT---IIILNNRKFANSLVGVQQQLQA 330
Query: 3758 AFSIDIIRHKDSMDE-------LFSHRSEIFGTCGEEQKTVLQEKTE---SLIQQYEAIS 3807
+ + E LF+ +S++ QK + + + + + +E +
Sbjct: 331 FNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRAN---NQKVYMPREGKLISDINKAWERLE 387
Query: 3808 LLNSER-------YARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQ 3860
ER R E+ + L +F W+ E + L++Q + D +
Sbjct: 388 KAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQ-DNFGFDLPAVEA 446
Query: 3861 QQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 3920
++ + IA ++ + ++ + +L+ N + + + + ++ + E +R
Sbjct: 447 ATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRA 506
Query: 3921 RA------LALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECIS 3974
R L L + + I ++ D+++ ++ + + L + L+
Sbjct: 507 RRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLL------------ 554
Query: 3975 DNKSATVELEKLQPSFEALKRRGEELIGRSQGAD----KDLAAKEIQDKLDQMVFFWEDI 4030
K VE + +A + RG + D K + I+D++ M F ++++
Sbjct: 555 -QKHTLVEADI---GIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQEL 610
Query: 4031 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4090
A ER + + L + FW +MA I++ + I+ + G D + + + +
Sbjct: 611 CQLAAERRARLEESRRLWKFFW-EMAEEEGWIREKEKILSS-DDYGKDLTSVMRLLSKHR 668
Query: 4091 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4150
++E G E G D+I A ++R+ I + W NL + R ++L
Sbjct: 669 AFEDEMSGRSGHFEQAIKEGEDMI-AEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRL 727
Query: 4151 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQI 4210
E+A Q+Q + W+ + ++K+ + VG D + + + + K+ E+ +
Sbjct: 728 EEA-SLLHQFQADADDIDAWMLD-ILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 785
Query: 4211 EMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270
++ L+ Q + ++ + D +R L+ ++ ++ + E R+ L+ L F
Sbjct: 786 TLDTLHEQASALPQEHAESPD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMF 842
Query: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHV--LKNDVLAHQATVETVNKA 4328
A + W+ E+ L+ + K+ ++E+ +H L+ ++ + V VN+
Sbjct: 843 SEA-DACELWIDEKEQWLNNMQI---PEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQI 898
Query: 4329 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFH---SEIED 4385
+L+ S + ++++ + +N W + + ++ L S L Q +H +E +
Sbjct: 899 ARQLMHSGHPSE-KEIKAQQDKLNTRWSQFRELVDRKKDALLSALS-IQNYHLECNETKS 956
Query: 4386 FLLELTRM-ESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLS 4444
++ E T++ ES G+ R+ +L + ++AK + +K L
Sbjct: 957 WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVA-IEAKLSDLQKEAEK-----LE 1010
Query: 4445 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 4504
+ +A + W + + ++ R++ L EA L +F L +F +WL+ +
Sbjct: 1011 SEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ-QFLRDLDDFQSWLSRTQ 1069
Query: 4505 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIK 4564
++ P+ L + +H+ NE++ + + ++ G + + ++
Sbjct: 1070 TAIASEDMPNT-LTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1128
Query: 4565 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 4624
L ++ + W ++ + E ++L +QF K+ +L + E L + E+
Sbjct: 1129 QRLQALDTGWNEL-HKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-AHTEMPT 1186
Query: 4625 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKW 4684
+ + + K ++F T+ + + + TGR L + D +++K
Sbjct: 1187 TLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSD---------RIQEKV 1237
Query: 4685 DTVCGKSVERQHKLEEALLFSGQFMDALQALVDW----LYKVEPQLAEDQPVHGDLDLVM 4740
D++ + + + E L+ D + L D L+ E L + + +
Sbjct: 1238 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1297
Query: 4741 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 4800
+ H+ F EL + +++ G +LI + VK +L L W+ + +
Sbjct: 1298 SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ 1357
Query: 4801 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEA-----LQSLIDTHK 4855
+K RL A K AE+F + L +WL E ++ D T Q +++
Sbjct: 1358 TKAQRLFDANK-AELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQM 1416
Query: 4856 EFMKK-VEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQR 4914
E KK +EE + + G+ + ++ +F E+L + +
Sbjct: 1417 EVRKKEIEELQSQAQALSQEGK---------STDEVDSKRLTVQTKFMELLEPLNERKHN 1467
Query: 4915 LETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTR 4974
L + N ++ +E+L W + N+ V+ LI ++QT +E+
Sbjct: 1468 LLASKEIHQFNRDVEDEIL----WVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQG 1523
Query: 4975 KQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQL 5034
QP +D + + + +NI + S I Q
Sbjct: 1524 HQPRIDDIFE--RSQNI----------------------------VTDSSSLSAEAIRQR 1553
Query: 5035 SARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVM 5089
A +Q+W L +E K + RLEE + FD + WM+ ++ +M
Sbjct: 1554 LADLKQLWGLLIEETEKRH---RRLEEAHRAQQYYFDAAEAE--AWMSEQELYMM 1603
Score = 94.7 bits (234), Expect = 2e-18
Identities = 285/1533 (18%), Positives = 577/1533 (37%), Gaps = 215/1533 (14%)
Query: 592 LLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE-ELGSSVKEARLYEGKMSQNF 650
++ W++EM++ + ++G L VE L+ HT VE ++G + R +Q F
Sbjct: 527 IMDWMDEMKVLVLSQDYGKHLLGVEDLLQK----HTLVEADIGIQAERVRGVNAS-AQKF 581
Query: 651 HTS-----------YAETLGKLETQY---CKLKETSSFRMRHLQSLHKFVSRATAELIWL 696
T + + +E Y C+L R+ + L KF E W+
Sbjct: 582 ATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWI 641
Query: 697 NEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQT 756
EKE+ + D+ + +++ + E+ + F E + E H +
Sbjct: 642 REKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK 701
Query: 757 VEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCD 816
+ ++ Q ++QL ++ ++E + QF +DA ++++++ D +K S D
Sbjct: 702 IRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWML---DILKIVSSSD 758
Query: 817 HNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPD------------ 864
+ L++ D E++ + ++ +L ++ + Q SPD
Sbjct: 759 VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERY 818
Query: 865 -HVLKNT-ISVKAVCDYRQIEITICKNDECVL--EDNSQRTKWKVISPTGNEAMVPSVCF 920
V + T + +A+ D + + D C L ++ Q I + V F
Sbjct: 819 KEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF 878
Query: 921 LIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLIS--------WNYLRKDLDLVQT 972
P + ASRV Q L H H + K + + W+ R+ +D +
Sbjct: 879 ESLEPEMN--NQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKD 936
Query: 973 WNLEKLR-SSAPGECHQIMKNLQAHYE--DFLQDSRDSVLFSVADRLRL---EEEVEACK 1026
L L + EC++ ++ + + QD + + +A + +L E ++ A +
Sbjct: 937 ALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIE 996
Query: 1027 ARFQHLMKSMEN-EDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRT------ 1079
A+ L K E E + A+ +S L I EE + + R SL +
Sbjct: 997 AKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLR 1056
Query: 1080 ---DRDAW---QDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF-------------LH 1120
D +W A+ + +T + ++L + + + + D++ +
Sbjct: 1057 DLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVT 1116
Query: 1121 QSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKL 1180
Q + + LR L L + ++ + N L + ++D K E L
Sbjct: 1117 QGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDT----KQAEAFL 1172
Query: 1181 SQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNL 1240
+ +E VLA +TL + +K + + +D K V E RL + N+
Sbjct: 1173 NNQEYVLAHTEMP----TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNI 1228
Query: 1241 DLERYQEKGSQLQERWHR---VIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ 1297
+ +R QEK + +R + ++L +R + +Q+ L D + L WI E
Sbjct: 1229 NSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQE----LSLWINEKMLT 1284
Query: 1298 QEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQY-------STIVKDY 1350
+ M +++R L + + A AE+ N+ LD+ +K Q +VK+
Sbjct: 1285 AQDMS---YDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEK 1341
Query: 1351 ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISD-- 1408
L +ES ++ +R + ++ TQ DL L + Q Y D
Sbjct: 1342 LTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLES-QIQSDDYGKDLT 1400
Query: 1409 ALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQ- 1467
++ L ++++++E + + ++++EL L++ +GK+T + ++ +E
Sbjct: 1401 SVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQ--EGKSTDEVDSKRLTVQTKFMELL 1458
Query: 1468 QVLSEE---LTTKKE--QVSEAIKTSQIFLAK---------HGHKLSE-----KEKKQIS 1508
+ L+E L KE Q + ++ +++ + HGH L K+ + +
Sbjct: 1459 EPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQ 1518
Query: 1509 EQLNALNKAYHDLCDGSAN------------------QLQQLQSQLAHQTEQKTLQKQQN 1550
+++ D+ + S N L+QL L +TE++ + ++
Sbjct: 1519 KEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA 1578
Query: 1551 TCHQQL----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSF 1606
QQ + +W+ + E + + +Q ++ K L+ +D
Sbjct: 1579 HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQL 1638
Query: 1607 ATVVKDIEGFMEENQTKLSPRELTALREKLHQ-----AKEQYEALQEETRVAQKELEEAV 1661
+ + + ++S R+ +KL+ A+E+ L E R+ Q E
Sbjct: 1639 SKTSRALVADSHPESERISMRQSKV--DKLYAGLKDLAEERRGKLDERHRLFQLNREVDD 1696
Query: 1662 TSALQQETEKSKAAKELAENKKKIDALLD----WVTSVGSSGGQLLTNLPGMEQLSGASL 1717
E E + EL ++ + + L + + G+ G + + + + S
Sbjct: 1697 LEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSG 1756
Query: 1718 EKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAF-LDQHGHN 1776
A + G+N+A L E++ R Q L + + + + F Q H
Sbjct: 1757 HSDAATIAEWKDGLNEAWADL---LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHK 1813
Query: 1777 LTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ---------------DELQKFL 1821
PEE Q + L+ ++T +A QV+ LQ D++QK
Sbjct: 1814 KLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQK-- 1871
Query: 1822 QDHKEFESW---LERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI------------ 1866
++++ E+W L+ E + G S+++ + EDVI
Sbjct: 1872 RENEVLEAWKSLLDACESRRVRLVDTGDKFRFF-SMVRDLMLWMEDVIRQIEAQEKPRDV 1930
Query: 1867 --------SHKG---DLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTA 1915
+H+G ++ S +++ S K + +K+KL TE+
Sbjct: 1931 SSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYAS--EEIKEKLLQLTEKRKE 1988
Query: 1916 LHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWM 1948
+ K L ++L + HQF A +AW+
Sbjct: 1989 MIDKWEDRWEWLRLIL-EVHQFSRDASVAEAWL 2020
Score = 53.9 bits (128), Expect = 4e-06
Identities = 74/402 (18%), Positives = 166/402 (41%), Gaps = 49/402 (12%)
Query: 472 DVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTL--------RLEC 523
D+ ++Q+C+ L + + +D +Y + L + ++ Q + L ++E
Sbjct: 1263 DLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEK 1322
Query: 524 TNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDE 583
+ E V LT H E L T + + F +AEL S ++
Sbjct: 1323 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLF--DANKAELFTQSCAD-- 1378
Query: 584 GNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYE 643
L W+ ++ +++ ++G DL SV + L+ QQ + +E ++E +
Sbjct: 1379 --------LDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA 1430
Query: 644 GKMSQNFHTSYAETLGKL--ETQYCKLKETSSFRMRHL---QSLHKFVSRATAELIWLNE 698
+SQ ++ +L +T++ +L E + R +L + +H+F E++W+ E
Sbjct: 1431 QALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGE 1490
Query: 699 KEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQ----DVFRSLQDTAELLSLENHPAK 754
+ + D N + L E++ Q D+F Q+
Sbjct: 1491 RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNI----------VT 1540
Query: 755 QTVEAYSAAVQSQLQWMKQLC-LCVEQ------HVKENTAYFQFFSDARELESFLRNLQ- 806
+ + A++ +L +KQL L +E+ ++E Q++ DA E E+++ +
Sbjct: 1541 DSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQEL 1600
Query: 807 DSIKRKYSCDHNTSLSRLE--DLLQDSMDEKEQLIQSKSSVA 846
+ + + D +++S L+ +L+ ++++ + + S +
Sbjct: 1601 YMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTS 1642
Score = 43.9 bits (102), Expect = 0.004
Identities = 48/248 (19%), Positives = 101/248 (40%), Gaps = 17/248 (6%)
Query: 567 KPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIH 626
+P+ + ++S E R V + + WV E + G++L +V+L ++ Q +
Sbjct: 1459 EPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQ 1518
Query: 627 TSVEELGSSVKEARLYEGKMSQNFHTSYA--------ETLGKLETQYCKLKETSSFRMRH 678
++ G + ++E SQN T + + L L+ + L E + R R
Sbjct: 1519 KEIQ--GHQPRIDDIFE--RSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRR 1574
Query: 679 LQSLHK----FVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQD 734
L+ H+ + A AE W++E+E ++ + + + + + L +E+ +
Sbjct: 1575 LEEAHRAQQYYFDAAEAEA-WMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAE 1633
Query: 735 VFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSD 794
L T+ L ++HP + + + V +K L + E FQ +
Sbjct: 1634 TVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNRE 1693
Query: 795 ARELESFL 802
+LE ++
Sbjct: 1694 VDDLEQWI 1701
Score = 33.5 bits (75), Expect = 5.9
Identities = 50/249 (20%), Positives = 93/249 (37%), Gaps = 34/249 (13%)
Query: 549 KAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRF---VYELLSWVEEMQMKLER 605
KA+ + K + +W + + E + + RF V +L+ W+E++ ++E
Sbjct: 1865 KADDIQKRENEVLEAW-KSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEA 1923
Query: 606 AEWGNDLPSVELQLETQQHIHTSVE----------ELGSSVKEARLYEGKMSQNFHTSYA 655
E D+ SVEL + Q I ++ ELG S+ + Y S+
Sbjct: 1924 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHY---ASEEIKEKLL 1980
Query: 656 ETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKE----EEELAYDWSDN 711
+ K + K ++ + +R + +H+F A+ WL +E E+ D
Sbjct: 1981 QLTEKRKEMIDKWEDRWEW-LRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQS-VDE 2038
Query: 712 NSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENH----------PAKQTVEAYS 761
+ + F + +E+ L T ELL + P+ + S
Sbjct: 2039 VEKLIKRHEAFEKSAATWDERFSALERL-TTLELLEVRRQQEEEERKRRPPSPEPSTKVS 2097
Query: 762 AAVQSQLQW 770
+SQ QW
Sbjct: 2098 EEAESQQQW 2106
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
[Homo sapiens]
Length = 8749
Score = 355 bits (911), Expect = 7e-97
Identities = 786/4227 (18%), Positives = 1654/4227 (39%), Gaps = 578/4227 (13%)
Query: 1022 VEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDR 1081
+E K + Q +++ + +DKE + K S L+ +LE+ +R +
Sbjct: 4221 IEDLKDQKQKMIEHLNLDDKE--LVKEQTSHLEQRWFQLEDLIKRKI------------- 4265
Query: 1082 DAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEK 1141
Q + + E Q Q+L + L QSP NLL
Sbjct: 4266 ---QVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQ------NLL--- 4313
Query: 1142 MDHVYGLSTVYLNKLKTVDVIVRS-IQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTL 1200
MDH+ ++L+ ++++S I+DA+ ++ ++ L++ +V+ LS ++H + L
Sbjct: 4314 MDHL-----AICSELEAKQMLLKSLIKDADRVMA--DLGLNERQVIQKALSDAQSHVNCL 4366
Query: 1201 RHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTP-ERNLDLERYQEKGSQLQERWHRV 1259
+ + + + L E+ V + S++ ER + ++E L + +
Sbjct: 4367 SDLVG--QRRKYLNKALSEKTQFLMAVFQATSQIQQHERKI---MFREHICLLPDDVSKQ 4421
Query: 1260 IAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQ 1319
+ + Q+ L++ Q + A L+K E T Q++ G+ ++ + + + + Q+
Sbjct: 4422 VKTCKSAQASLKTYQNEVTGLWAQGRELMK---EVTEQEKSEVLGKLQELQSVYDSVLQK 4478
Query: 1320 TA-LFAEIERN-------QTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKR 1371
+ E+E+N + D+ + +Q + IV E+ LM + + +Q K
Sbjct: 4479 CSHRLQELEKNLVSRKHFKEDFDKACHWLKQ-ADIVTFPEINLMNESSELHTQL---AKY 4534
Query: 1372 RRMLSSSDAITQEFMDL-RTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEK 1430
+ +L S + L RT T L +L Y+S+ L L + V+ ++ K
Sbjct: 4535 QNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYK 4594
Query: 1431 VKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKE-QVSEAIKTSQ 1489
V+E + LAR T+ +++E L + +L ++ + + +
Sbjct: 4595 VQEAI-----LARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAIL 4649
Query: 1490 IFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQK-TLQKQ 1548
+A G + E +K+ E + + + L L +L QTEQ+ +L +
Sbjct: 4650 DEVAGLGEAVDELNQKK--EGFRSTGQPWQP---DKMLHLVTLYHRLKRQTEQRVSLLED 4704
Query: 1549 QNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFAT 1608
+ +Q+ E +C + + +++ Q + ++ L A +K + + +
Sbjct: 4705 TTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQDSGI 4759
Query: 1609 VVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQE 1668
V+K + +E+ L P R ++ + + + L E E + ++ +
Sbjct: 4760 VLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4819
Query: 1669 TEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSG-ASLEKGALDTTDG 1727
TE S++ LDW+ V + +LSG L+ D +
Sbjct: 4820 TEMSRS--------------LDWLRRVKA-------------ELSGPVYLDLNLQDIQEE 4852
Query: 1728 YMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQ 1787
+ E++ +M A + +++ F A + A L+ H+L
Sbjct: 4853 IRKIQIHQEEVQSSLRIMNALSHK---EKEKFTKAKELISADLE---HSLA--------- 4897
Query: 1788 KLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSS 1847
+L EL +L +A L ++ + + Q++ Q + WLE +++ L+ G
Sbjct: 4898 ELSELDGDIQEALRTRQATLTEIYS---QCQRYYQVFQAANDWLEDAQELLQLAGNGLDV 4954
Query: 1848 PETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLK 1907
+L FS + H L+ +S +P L+K K
Sbjct: 4955 ESAEENLKSHMEFFSTEDQFHSN------------LEELHSLVATLDP-----LIKPTGK 4997
Query: 1908 -DATERYTALHSKCTRL----GSHLNML---LGQYHQFQNSADSLQAWMQACEANVEKLL 1959
D ++ +L + R+ G+ +++L Q+H +Q + + V +L+
Sbjct: 4998 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREE-----------VIELM 5046
Query: 1960 SDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETT 2019
+DT + +++ + +E+L+EH+ V + I+ +E + + + + +
Sbjct: 5047 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDAS 5106
Query: 2020 DSILSHFQSLSYS--------LAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGK 2071
+ LS + + ++ +L+ A+ + ++ + I +++ L G
Sbjct: 5107 KATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGS 5166
Query: 2072 QVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEV 2131
S + L + ++ +Q+S+L R+ ++ + T + E+
Sbjct: 5167 SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEI 5226
Query: 2132 SQRFEQLCLQQQEKESSLKKLLPQA----EMFEHLSGKLQQFMENKSRMLASGNQPDQDI 2187
+ + CL QEK + KL+ Q EM E ++ +++ L + P +I
Sbjct: 5227 TA-MQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN---PTIEI 5282
Query: 2188 THFFQQIQELNLEMEDQQENLDTLEH------------LVTELSS--CGFALDLCQHQDR 2233
+++Q L E + ++N++ + L +ELS ALDL
Sbjct: 5283 DAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDL------ 5336
Query: 2234 VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAK 2293
K ++Q +KE E+ ++ QE + +KL + L + + T+ + AK
Sbjct: 5337 -----KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK---TDNVVQAK 5388
Query: 2294 ELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSV 2353
+K + G ++ N K L+ + + + G+ G L +
Sbjct: 5389 TDQKVL-------------GEELDGCNSKLMELDAAVQKFL--EQNGQLGKPL---AKKI 5430
Query: 2354 GSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQW 2413
G + H + + + + +S +N + L E E L+ IL +E+ A+ + W
Sbjct: 5431 GKLTELHQ-QTIRQAENRLSKLN----QAASHLEEYNEMLELILKWIEKAKVLAHGTIAW 5485
Query: 2414 ----------------LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKI 2457
LE +E+ ++AM+ + T E +AEL + + ++
Sbjct: 5486 NSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEEL 5545
Query: 2458 -QKVKEALAGLLVTYPNSQEAE-NWKKIQEELNSRWERATEVTVARQRQLEESASHLACF 2515
Q +K L L + ++ E KK+Q L T V R L+E SH
Sbjct: 5546 RQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRL-SLKEQLSHRQHL 5604
Query: 2516 QAAESQLRPWLMEKELMMG-------VLGPLSIDPNMLNAQKQQ-------------VQF 2555
+ L+P + +L V+ L + L Q++ +Q
Sbjct: 5605 LSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQA 5664
Query: 2556 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 2615
+ ++E Q+ + L + +G D ++TS +Q ELQ+ + EL K+
Sbjct: 5665 AVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQ-ELQAQISRHEELAQKIKG---- 5719
Query: 2616 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL---- 2671
YQE + L+ K + + + + + T E V+ E T ++ +L
Sbjct: 5720 ----------YQEQIASLNSKCKMLTMKAKHATMLLTVTE-VEGLAEGTEDLDGELLPTP 5768
Query: 2672 ----EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLE------------TVALPLQGL 2715
+ TL ++ GE+ E+ +V +
Sbjct: 5769 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYY 5828
Query: 2716 EDLAADRIN----RLQAALASTQQFQQ----------MFDELRTW--------------- 2746
+ L+A+R+ ++ + +++Q+F + + D R+W
Sbjct: 5829 QALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLY 5888
Query: 2747 --LDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAE---------- 2794
L+ +Q Q IS K+E ++ +L E+ E +S ++ ++ E
Sbjct: 5889 EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINE 5948
Query: 2795 -----GESLLLSVPPGE--EKRTLQNQLVELKNHWEELSKKTADRQSRLKDCM------- 2840
E L+ + E+ LQ+ L L + K + ++ L++ +
Sbjct: 5949 LQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQ 6008
Query: 2841 ---QKAQKYQWHVEDLVPWIEDCKAKM-SELRVTLDPVQLESSLLRSKAMLNEVEKRRSL 2896
Q Q+Y+ ++L W+ KA + + L +P+ +E+ L+ + ML E+E++
Sbjct: 6009 RQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVA 6068
Query: 2897 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 2956
L L S +E+ + + KA + + +L+ GSL E+ + L + Q +
Sbjct: 6069 LSEL----------SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLN 6118
Query: 2957 FKNIEKKVEGAKHQLEIFDALGSQ--------ACSNKNLEKLRAQQEVLQALEPQVDYLR 3008
+ ++ E + L + G Q + + L+ Q+E+ Q L Q LR
Sbjct: 6119 MQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLR 6178
Query: 3009 NFTQGLVE------DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3062
+ E A DA + + +V QE L ++ +S M K E + Q
Sbjct: 6179 SVASRGEEILIQHSAAETSGDAGE---KPDVLSQE-LGMEGEKSSAEDQMRMKWESLHQE 6234
Query: 3063 HCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECR 3122
+++ + + + E Q L+ + + K D+ +
Sbjct: 6235 FSTKQKLLQNVLEQEQE--------------QVLYSRPNRLLSGVPLYKGDVPTQDKSAV 6280
Query: 3123 HMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDAT 3182
L L GL + E ++ Q G A+++ + L + L+D
Sbjct: 6281 TSL-------LDGLNQAFEEVSSQSGG------AKRQSIHLEQKLYDGVSATSTWLDDVE 6327
Query: 3183 TAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDC 3242
A AL TE + NQ++ + + + ++ + L G +
Sbjct: 6328 ERLFVATALL-PEETETCLFNQEIL------AKDIKEMSEEMDKNKNLFSQAFPENGDNR 6380
Query: 3243 DVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIAN 3302
DV +E + + R + L+ V QR Q++E L FQ+ L+ L + LAD + +I
Sbjct: 6381 DV--IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIIL- 6437
Query: 3303 QKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLES 3362
QK + + V QI+ + + L + A + L+ G + L + +L
Sbjct: 6438 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDK------LQVEQPSMQELSK 6491
Query: 3363 LESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAK- 3421
L+ + EL+ +R+ L L L Q+ + ++D L ++K+A + + + +
Sbjct: 6492 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6551
Query: 3422 IQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQD 3481
IQQ + +HK + +E+H + + S E +E L A+ S +
Sbjct: 6552 IQQLLDKHKEYFQGLESHMILTETLFR---KIISFAVQKETQFHTE----LMAQASAVLK 6604
Query: 3482 RCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLAL 3541
R ++ L+ L ED+ E+ L VE + SV + + +D L + + L
Sbjct: 6605 RAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHL 6664
Query: 3542 NEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQ 3601
+ + + Q + +G+ LL + + ++ +L+ + + T SK L LE
Sbjct: 6665 KSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHRLET 6721
Query: 3602 ARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQ--------IPQFQQRQKELKKE 3653
+ T++QS +L WL+ ++ L QS T Q + F + KE+ +
Sbjct: 6722 ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQ 6781
Query: 3654 VMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS---DANEQYKLVSDTIGQ-RVDEID 3709
VL T N++ R L ++ R L ++ S D V + + Q ++D++
Sbjct: 6782 SSLKSSVLSTGNQLLR-LKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 6840
Query: 3710 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ---------LQVQKAFS 3760
+ A ++W++ + I+ ++D LQ K F
Sbjct: 6841 S--------RHAISEVMSWIS------LMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFK 6886
Query: 3761 IDIIRHKDSMDELFSHRSEIFGTCGEEQ---KTVLQEKTESLIQQYEAISLLNSERYARL 3817
IDI + ++D + +I E + KT E+ ++ + ++ + L +E+ L
Sbjct: 6887 IDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLL 6946
Query: 3818 ERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKP 3877
E +++ + L W E + Q D ++ ++ + L + I +
Sbjct: 6947 EGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKAKEK 7005
Query: 3878 HIDKLLKIGPQLKELNPEE-GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQIT 3936
++K+ + G L + E+ +V ++ +A + V Q + L + Q +
Sbjct: 7006 EVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHK 7065
Query: 3937 EFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRR 3996
DKI L SR R L+ ++ ++ + + ++ +LEK + S +
Sbjct: 7066 VAFDKINSYLMEARYSLSRFR---LLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSI 7122
Query: 3997 GEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMA 4056
+L+ + + + L ++ W ++ E+ +L+L +++
Sbjct: 7123 TNQLLKECHPP----VTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSK 7178
Query: 4057 ALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLH------EELEFIRILG 4110
+T++ +D ++L + I +V A I++ D L + L F+ LG
Sbjct: 7179 QCASTVQQQEDRTNELLKAATNKDIADDEV--ATWIQDCNDLLKGLGTVKDSLFFLHELG 7236
Query: 4111 ADL---IFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAM 4167
L + A + + S+ + A E + L K + ++QA V +T
Sbjct: 7237 EQLKQQVDASAASAIQSDQLSLSQHLCALE-------QALCKQQTSLQAGVLDYETFAKS 7289
Query: 4168 FDWLDNTVIKLCTM-----PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELM 4222
+ L+ +++ + P +DL+T+++++ E+K ++ ++++LN G +
Sbjct: 7290 LEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL 7349
Query: 4223 LKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLT 4282
D++I R + L W + + R KL+ LL F E M +L
Sbjct: 7350 -----PLNDKEIKR--MQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7402
Query: 4283 HTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDAS 4342
TE+ L + ISG+ + + + H + + ++ + Q + ++ G LLE DD
Sbjct: 7403 QTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD 7460
Query: 4343 SLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHS---EIEDFLLELTRMESQLSA 4399
+L ++ W+ V+++ ++R + S ++Q Q + ++ +L+E++ +
Sbjct: 7461 EFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLG 7520
Query: 4400 SKPTGGLPETAREQLDTHMELYSQLKAKEE-TYNQLLDKGRLMLLSRDDSGSGSKTEQSV 4458
S P +P L ++ ++ +++ +Y ++ G+ +LLS D SG+ + + +
Sbjct: 7521 SVP---IPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD-SGAEAALQAEL 7576
Query: 4459 ALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN 4518
A +++KW S ++EE+K KL L + + + + + L ++ L+ + P
Sbjct: 7577 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHH--E 7634
Query: 4519 TVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVV 4578
+ ++ K N V + D + +L + L D+ ++ + +Q +WE++
Sbjct: 7635 ELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC 7694
Query: 4579 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 4638
+ R + + + F E K+L +WL ES + +I + KL+ +E
Sbjct: 7695 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEE 7754
Query: 4639 FQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKL 4698
K + R +A E + +++ LG+V D+W + R KL
Sbjct: 7755 IAIAQENKIQLQQMGERLAKASHESK-----ASEIEYKLGKVNDRWQHLLDLIAARVKKL 7809
Query: 4699 EEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL---DLVMNLMDAHKVFQKELGK 4755
+E L+ Q + +L WL +E +LA+ P+ D + + ++ + Q+++ K
Sbjct: 7810 KETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEK 7867
Query: 4756 R-TGTVQVLKRSGRELIENSRD------DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQ 4808
TG VL E++ + D + ++ + L RW +C +S+ ++ ++E+
Sbjct: 7868 HSTGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7925
Query: 4809 ALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 4868
+ + F D +WL +E+T A P + + ++ KE +KK E + V
Sbjct: 7926 TWRLWQKFLDDYSRFEDWLKSSERT----AAFPSSSGVIYTVA---KEELKKFEAFQRQV 7978
Query: 4869 NSAVAMGEVI-------LAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 4921
+ + E+I D ++K + R++ + +RL+ + +
Sbjct: 7979 HECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQ 8038
Query: 4922 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDR-----VKALIAEHQTFMEEMTRKQ 4976
+ +L W+ + L NI+ V+A I + + F +E++
Sbjct: 8039 REEFETARDSILVWLTEMDLQL---------TNIEHFSECDVQAKIKQLKAFQQEISLNH 8089
Query: 4977 PDVDRVTKTYKR--KNIEPTHAPFIEK 5001
++++ ++ + EP A IE+
Sbjct: 8090 NKIEQIIAQGEQLIEKSEPLDAAIIEE 8116
Score = 328 bits (840), Expect = 1e-88
Identities = 871/4902 (17%), Positives = 1888/4902 (38%), Gaps = 672/4902 (13%)
Query: 547 HLKAEPLTKATHSSSTSWFRKPM--TRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLE 604
HL +E K HSS S + M T + + +S +E R L W + + + E
Sbjct: 2158 HLLSE--LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDE 2215
Query: 605 RAEWGND---------------LPSVELQLETQQHIHTS---VEELGSSVKEARLYEGKM 646
W N+ L + EL E + + +EEL S V + + ++
Sbjct: 2216 IEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLK----EL 2271
Query: 647 SQNFHTS------YAETLGKLETQYCKLKETSSFRMRHLQS----LHKFVSRATAELIWL 696
++N T A+ + KLE ++ E + ++ + + KF++ T W
Sbjct: 2272 TKNLETPPDLQFIEADLMQKLEHAK-EITEVAKGTLKDFTAQSTQVEKFINDITT---WF 2327
Query: 697 NEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQT 756
+ EE + + + N + + K+ ++ EL+ +Q S Q+ L + H A+
Sbjct: 2328 TKVEESLM--NCAQNETCEALKK--VKDIQKELQSQQSNISSTQENLNSLCRKYHSAE-- 2381
Query: 757 VEAYSAAVQSQL---QWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKY 813
+E+ A+ + + + QLC + ++E+ F +E + + + + K
Sbjct: 2382 LESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK-HFSESMQEFQEWFLGAKAAAKE-- 2438
Query: 814 SCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTIS- 872
S D LE L D + + + +S + ++ +T+ H+ K +S
Sbjct: 2439 SSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYA-------HLSKQIVSS 2491
Query: 873 ----VKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKD 928
+ + Q + C D+ L+D + S G+ L ++
Sbjct: 2492 IQEQITKANEEFQAFLKQCLKDKQALQDCA--------SELGSFEDQHRKLNLWIHEMEE 2543
Query: 929 AIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLD-LVQTWNLEKLRSSAPGECH 987
+ +S Q + +++H L R+ LD L Q L G+
Sbjct: 2544 RFN-TENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEG 2602
Query: 988 QIMKNLQAHYEDFLQDSRD---SVLFSVADRLRLEEEVEAC----KARFQHLMKSMENED 1040
++ L +++ L+ +++ S ++ + LEE +++ KA L +
Sbjct: 2603 RLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLG 2662
Query: 1041 KEETVAKMYISELKNIRLRLEEYEQRVVKRI----QSLASSRTD------------RDAW 1084
++T+ K +S++++I L E E ++ I Q+L SS + ++ W
Sbjct: 2663 SKDTLEKR-LSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVW 2721
Query: 1085 QDNALRIAEQEHTQEDL-----------QQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRS 1133
D + T E + QL +++V K + L P L
Sbjct: 2722 ADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLD 2781
Query: 1134 EL-NLLVEKMDHVYGLSTVYLNKL----KTVDVIVRSIQDAELLVKGYEIKL-------S 1181
L ++L E DH L + KT D + EL + +I
Sbjct: 2782 HLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRK 2841
Query: 1182 QEEVVLADLSALEA-----HW-----STLRHWLSDVKDKNSV----FSVLDEEIAKAKVV 1227
EE+V L L+A W L W SD+ +S S + E I ++
Sbjct: 2842 VEEIVKDHLMYLDAVHEFTDWLHSAKEELHRW-SDMSGDSSATQKKLSKIKELIDSREIG 2900
Query: 1228 AEQMSR---LTPE-------------------RNLDLERYQEKGSQLQERWHRVIAQLEI 1265
A ++SR L PE D +++++ Q Q +++Q+ +
Sbjct: 2901 ASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMAL 2960
Query: 1266 RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFA- 1324
+ E L L+K T AQQ + G+ D ++ Q L A
Sbjct: 2961 SEQEFSGQVAQLEQALEQFSALLK----TWAQQLTLLEGKNTDEEIVECWHKGQEILDAL 3016
Query: 1325 -----EIERNQTKLDQCQKFSQQYST-------IVKDYELQLMTYKAFVESQQKSPGKRR 1372
E +++L++ +FS+ ST ++K+Y + +A Q K ++
Sbjct: 3017 QKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNC--LCLQASKGCQNKEQILQQ 3074
Query: 1373 RMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEE--EEKVVEEEKQEHVEK 1430
R + Q ++ + TA Q++ +S +L++++E E + K +
Sbjct: 3075 RFRKAFRDFQQWLVNAKIT-TAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLS 3133
Query: 1431 VKELLGWVSTL--ARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTS 1488
ELL + T A+ Q K T+++ ++ + + +++ E L + + + +
Sbjct: 3134 KGELLSTLLTKEKAKGIQAKVTAAK-EDWKNFHSNLHQKESALENLKIQMKDFEVSAEPI 3192
Query: 1489 QIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQ 1548
Q +L+K +K + E N L +DL + Q+LQS L E + Q
Sbjct: 3193 QDWLSK--------TEKMVHESSNRL----YDL-PAKRREQQKLQSVLE---EIHCYEPQ 3236
Query: 1549 QNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFAT 1608
N ++ + L W GQA H+ AL + D I F+
Sbjct: 3237 LNRLKEKAQQL--WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSL 3294
Query: 1609 VVKDIEGFMEENQTKL-SPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQ 1667
+K+++ +M + L S T+ + L + EAL + +KE++ + +
Sbjct: 3295 GIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQ--EKEIQMKMIVTRGE 3352
Query: 1668 ETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGM-----EQLSGASLEKGAL 1722
++ + + + ++++ ++ D S+ S+G + + L G G G +
Sbjct: 3353 SVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWM 3412
Query: 1723 DTTDGYMGVN--QAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE 1780
D+ + + + Q E DK + KA+ LL+++ +L+ S ++ G +T
Sbjct: 3413 DSMEANLNESERQHAELRDKTTMLGKAK---LLNEE---VLSYSSLLETIEVKGAGMT-- 3464
Query: 1781 EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELEN 1840
E + Q +L +L+E+Y +++ + + + L Q++ +D K FE WL + +++L+
Sbjct: 3465 EHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQ 3524
Query: 1841 MHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGN 1900
S+L+ E + +L+ GQ +L+ +E PS I
Sbjct: 3525 Y-----------SVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQ 3573
Query: 1901 LVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLS 1960
L+ + + A + + + N ++ + + + W++ E
Sbjct: 3574 AEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE------- 3626
Query: 1961 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET-- 2018
K+ EE+ ++ VE++ A++I+ D HV
Sbjct: 3627 -----------------KKWHEEVTAYRDEVEEVGARAQEIL--------DESHVNSRMG 3661
Query: 2019 --TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG--KQVS 2074
+ S +Q+L + E+ L++ I + + SL S G +N + ++
Sbjct: 3662 CQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKID 3721
Query: 2075 SLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQR 2134
+ + ++ + L T L +D+ + S L++ RE R ++ + A L+ ++ + ++
Sbjct: 3722 KVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQ 3781
Query: 2135 FEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHF---- 2190
++L +++ +L+K L A+ F L Q++ +L +P ++
Sbjct: 3782 LKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQL 3841
Query: 2191 --FQQIQELNLEMEDQ--------------------QENLDTLEHLVTELSSCGFAL--D 2226
++ +Q+ L E ++ +D L+ +L S G A+ +
Sbjct: 3842 SKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEE 3901
Query: 2227 LCQHQDRVQNLRKD--------FTELQKTVKER-------EKDASS--CQEQLDEFRKLV 2269
+ +DR+ NL+ LQ +K+ KD+ S C ++ L
Sbjct: 3902 IAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLE 3961
Query: 2270 RTFQK-------------WLKETEGSIPPT-ETSMSAKELEKQIEHLKSLLDDWASKGTL 2315
QK WL + + P+ + +S E KQ++H ++L + +
Sbjct: 3962 HELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQE----QART 4017
Query: 2316 VEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL-TEIQCDMSD 2374
++ C L N ++ TA D Q +I + + G+ K L +E+ + D
Sbjct: 4018 YLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQD 4077
Query: 2375 ----------------VNLKYEKLGGV------LHERQESLQAILNRMEEV--------H 2404
+N+ + V L +Q S+ I+ ++ ++ H
Sbjct: 4078 ADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEH 4137
Query: 2405 KEANSVL-QWLE-----------SKEEVLKSMDAMSSPTKTET------------VKAQA 2440
KE N + QWL+ +E++ ++ D E ++ A
Sbjct: 4138 KEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDA 4197
Query: 2441 ESNKAFLAELEQNSPKIQKVKEALAGL------LVTYPNSQEAENWKKIQEELNSRWERA 2494
ES L L++ + +Q+ K A+ L ++ + N + E K+ L RW +
Sbjct: 4198 ESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQL 4257
Query: 2495 TEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQ 2554
++ + + + L Q+ +L W E++ + S P+M
Sbjct: 4258 EDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHL 4317
Query: 2555 FMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE-LTDKLNSRS 2613
+ E EA++ + L + A ++ D+ L+ QV ++ S Q V L+D + R
Sbjct: 4318 AICSELEAKQMLLKSLIKDADRVMA---DLGLNERQVIQKALSDAQSHVNCLSDLVGQRR 4374
Query: 2614 SQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQ 2673
+++A+ + TQ+ + + +++ +++ + I P+ V +Q++ ++ L+
Sbjct: 4375 KYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKT 4434
Query: 2674 LDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALAST 2733
+EV EL + EQ K E+ +L+ + + + R+ L+ L S
Sbjct: 4435 YQNEVTGLWAQGRELMKEVTEQE-KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR 4493
Query: 2734 QQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVA 2793
+ F++ FD+ WL + + L +QL + + + ++ +
Sbjct: 4494 KHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQR 4553
Query: 2794 EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDL 2853
G+++L S+ + L +L L + + D+ ++++ + ++Y +E
Sbjct: 4554 TGQTILPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELT 4612
Query: 2854 VPWIEDCKAKMSELRVTLDPVQLESSLLRS---KAMLNEVEKRRSLLEILNSAADILINS 2910
+ + +A+ + + +E +L +A+L+EV ++ LN + ++
Sbjct: 4613 TQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRST 4672
Query: 2911 SEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ 2970
+ + + + TE+ + LE+ T +E ++ + +E++++ K +
Sbjct: 4673 GQPWQPDKMLHLVTLYHRLKRQTEQ---RVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE 4729
Query: 2971 LEIFDALGSQACSNKNL----EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAP--DGSDA 3024
Q+ N+ EKL+ + +L+ L+ T L + AP D
Sbjct: 4730 ---------QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAY 4780
Query: 3025 SQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMG 3084
+ HQ + Q E + + E+++ F + L + EL G
Sbjct: 4781 EKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPV 4840
Query: 3085 AIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALN 3144
+ + +Q +I +++ ++ + A + + + L L+ L L+
Sbjct: 4841 YLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELS 4900
Query: 3145 KQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQ 3204
+ G + E + RQ L + + +Y+ + ND A+E L G +VE +
Sbjct: 4901 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN-GLDVESAEE 4959
Query: 3205 QLADFKMFQKEQVDPLQMKLQQVNGLG---QGLIQSAGKDCDVQGLEHDMEEINARWNTL 3261
L F + D L++++ L LI+ GK+ LE + + R +
Sbjct: 4960 NLKSHMEFFSTE-DQFHSNLEELHSLVATLDPLIKPTGKE----DLEQKVASLELRSQRM 5014
Query: 3262 NKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIAN-QKPPSAEYKVVKAQIQEQ 3320
++ ++ LQ +Q A E ++ + DTE+ ++ ++ + ++ E
Sbjct: 5015 SRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEH 5074
Query: 3321 KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQ 3380
K L +++ + L+ + ++ ++ A + ++ + ++ RWT L + A ++K
Sbjct: 5075 KALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5134
Query: 3381 LEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHA 3440
LED + F+ + ++ + + KL S A++ + H ++E
Sbjct: 5135 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5194
Query: 3441 TDVHQAVKIGQSLSSLT-----SPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495
+ + + Q+LS L +P E+ L ++I ++Q R +Q++ L+ Q L
Sbjct: 5195 SALGMLRQ--QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELK 5252
Query: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQA 3555
+ + V W+ E ++ L + ++ + Q + L E N ++N++
Sbjct: 5253 DREMVETQINSVKCWVQETKEYLGNPTIE------IDAQLEELQILLTEATNHRQNIE-- 5304
Query: 3556 IKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEE 3615
K + ++ G +L E + + A++ + K ++ + + ++T +E
Sbjct: 5305 -KMAEEQKEKYLGLYTILPSE----LSLQLAEVAL-DLKIRDQIQDKIKEVEQSKATSQE 5358
Query: 3616 LTGWLREVEEELATSGGQ-SPTGEQIPQFQQRQKELKKEVMEHRLVLDTVN----EVSRA 3670
L+ ++++ ++L T + + + Q + QK L +E LD N E+ A
Sbjct: 5359 LSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEE-------LDGCNSKLMELDAA 5411
Query: 3671 LLELVPWRAREG--LDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAW 3728
+ + + + G L K + E ++ R+ +++ A ++Y + + L W
Sbjct: 5412 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5471
Query: 3729 VAETKRKLMALGPI------RLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFG 3782
+ K K++A G I +L + Q ++++ ID ++M E + + ++
Sbjct: 5472 IE--KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEID--SELEAMTEKLQYLTSVY- 5526
Query: 3783 TCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETR 3842
C E+ + ++ L ++ E + + R L+ A + +F ++L +E+ +
Sbjct: 5527 -CTEK----MSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQ 5581
Query: 3843 ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM-VE 3901
A L SP + L++Q + L + KP + + L+ + +
Sbjct: 5582 AT---LTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLC 5638
Query: 3902 EKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPL 3961
+ + ++++ Q+ + AV Q Q + +++ + + +E + P+
Sbjct: 5639 HAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQ---YEQEMKHLQQLIEGAHREIEDKPV 5695
Query: 3962 IPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLD 4021
+ + +++ IS ++ +++ Q +L + + L +++ A L E++ +
Sbjct: 5696 ATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE 5755
Query: 4022 QMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP------ 4075
ED+ V+ + + + + +T + ++ SP
Sbjct: 5756 GT----EDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSP 5811
Query: 4076 --------GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRK 4127
++ I Q +AE ++ + +H + + G +P
Sbjct: 5812 SPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS-----ASQEFYEPGL--EPSATA 5864
Query: 4128 SIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTD 4187
+ ++ +WE L E+ L +A++ +YQD+LQ++ ++ +KL P G
Sbjct: 5865 KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG-- 5922
Query: 4188 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQ-GELMLKKA--TDETDRDIIREPLTELKH 4244
+ + Q+ E + E+ Q E+ +L E ++ ++ D ++ ++ LT L
Sbjct: 5923 -RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 5981
Query: 4245 LWENLGEKIAHRQHKLEGAL----------LALGQFQHALEELMSWLTHTEELLDAQRPI 4294
+ K + ++ LE L AL +++ +EL SWL T+ LD
Sbjct: 5982 RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP 6041
Query: 4295 SGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG----NELLESSA--GDDASSLRSRL 4348
+P +E +L +N ++ + V +++ N LLE A D+A L +L
Sbjct: 6042 PKEPMDMEAQLMD---CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKL 6098
Query: 4349 EAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPE 4408
+ + + +++ +Q T Q+ + S+++ + ++ L+ ++ T +
Sbjct: 6099 RRLKGSLLELQRALHDKQLNMQGTAQEKE--ESDVDLTATQSPGVQEWLAQARTT--WTQ 6154
Query: 4409 TAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVV 4468
+ L EL +L ++ + +G +L+ + + + +L Q+
Sbjct: 6155 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE---- 6210
Query: 4469 SSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHK 4528
ME KS E+ + + ++++ QEF S +L VL Q +E
Sbjct: 6211 -LGMEGEKSSAEDQMRM--KWESLHQEF--------------STKQKLLQNVLEQEQEQV 6253
Query: 4529 VFANEVNAHRDQIIELDQTGNQL-KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRS 4587
+++ ++++ +G L K QD + +LL + +E+V S + G +
Sbjct: 6254 LYSRP-----NRLL----SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV---SSQSGGA 6301
Query: 4588 LDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQ 4647
+ ++ ++ WL+D E L + P++ + L + K +
Sbjct: 6302 KRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALL--PEETETCLFNQEILAKDIKEMS 6359
Query: 4648 PVYDTTIRTGRALKEKTL----LPEDSQKLD-------NFLGEVRDKWDTVCGKSVERQH 4696
D K K L PE+ D LG + V + + +
Sbjct: 6360 EEMD---------KNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKE 6410
Query: 4697 KLEEALLFSGQFMDALQALVDWLYKVEPQLAE--DQPVHGDLDLVMNLMDAHKVFQKELG 4754
+L++ L F +L D Y + +LA +QPV ++ + D K F
Sbjct: 6411 RLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFD---- 6466
Query: 4755 KRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAE 4814
G +++ +R + +E +L +L +D + + S++S L Q L
Sbjct: 6467 --AGIIELKRRGDKLQVEQPS------MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKS 6518
Query: 4815 VFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVA 4873
+ + L + L ++ + + + E +Q L+D HKE+ + +E +
Sbjct: 6519 QYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI------- 6571
Query: 4874 MGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETAL----SELVANAELL 4929
+ F +++++A Q + + T L S ++ A
Sbjct: 6572 ----------------------LTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR 6609
Query: 4930 EELLAWI--QWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK 4987
L +I W+ + DQ+ + + ++ V++ I E R +DR+T
Sbjct: 6610 GVELEYILETWSH---LDEDQQELSRQLEVVESSIPSVGLVEENEDRL---IDRITLYQH 6663
Query: 4988 RKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALE 5047
K+ + P + + G++ L +S S+ ++ ++NQL W L
Sbjct: 6664 LKSSLNEYQPKLYQVLDDGKRLLIS--------ISCSDLES-QLNQLGECW-------LS 6707
Query: 5048 RQRKLNDALDRLEE-LKEFANFDFDVWRKKYMRWMNHKKSRV 5088
K++ L RLE LK + + + + W+ K R+
Sbjct: 6708 NTNKMSKELHRLETILKHWTRYQSE--SADLIHWLQSAKDRL 6747
Score = 315 bits (808), Expect = 6e-85
Identities = 750/3948 (18%), Positives = 1533/3948 (38%), Gaps = 515/3948 (13%)
Query: 1019 EEEVEACKARFQHLMKSMENEDKEETVAKM------YISELKNIRLRLEEYEQRVVKRIQ 1072
+ EV A+ + LMK + ++K E + K+ Y S L+ RL+E E+ +V R
Sbjct: 4436 QNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR-- 4493
Query: 1073 SLASSRTDRDA---WQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSV- 1128
+ D D W A + E +L S+L K + L QSP ++
Sbjct: 4494 --KHFKEDFDKACHWLKQADIVTFPEI---NLMNESSELHTQLAKYQNILEQSPEYENLL 4548
Query: 1129 -------PTLRSELNLLVEKMDHVYGLSTVYLNKL-KTVDVIVR-------SIQDAELLV 1173
T+ LN ++DH Y + LN L + +VIV +Q+A L
Sbjct: 4549 LTLQRTGQTILPSLN----EVDHSY--LSEKLNALPRQFNVIVALAKDKFYKVQEAILAR 4602
Query: 1174 KGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVF------SVLDEEIAKAKVV 1227
K Y S E+ LS LEA + + +D+ + ++ ++LDE + V
Sbjct: 4603 KEYA---SLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAV 4659
Query: 1228 AEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTL 1287
E + R+ +K L +HR+ Q E R S LE ++ L
Sbjct: 4660 DELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL 4719
Query: 1288 IKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIV 1347
+ ++ +Q + E++ E+L +L ++ + L + + +
Sbjct: 4720 ERQLKSVKEEQSKVN----EETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAP-- 4773
Query: 1348 KDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYIS 1407
L + Y+ Q G+ + + S AI + + +R + T+ + +
Sbjct: 4774 ---HLDPLAYEKARHQIQSWQGELKLLTS---AIGETVTECESRMVQSIDFQTEMSRSL- 4826
Query: 1408 DALRRLEEE-----------EKVVEEEK--QEHVEKVKELLGWVSTLARNTQGKATSSET 1454
D LRR++ E + + EE + Q H E+V+ L ++ L+ + K T ++
Sbjct: 4827 DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKE 4886
Query: 1455 KESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNAL 1514
S D+E ++ E L + + EA++T Q L E ++ +
Sbjct: 4887 LISADLEHSLAELSELDGD-------IQEALRTRQATLT---------EIYSQCQRYYQV 4930
Query: 1515 NKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQ------QNTCHQQLEDLCSWVGQAER 1568
+A +D + + LQ + L ++ ++ L+ ++ H LE+L S V +
Sbjct: 4931 FQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDP 4990
Query: 1569 ALAGHQGRTTQQDLSALQ-KNQSDLKD--LQDDIQNRATS----FATVVKDIEGFMEENQ 1621
+ +Q +++L+ ++Q +D Q D+ R T+ + +++ M + +
Sbjct: 4991 LIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTE 5050
Query: 1622 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 1681
KLS L K + E E L E +A+ S + EK A +E A
Sbjct: 5051 KKLSEFSLL----KTSSSHEAEEKLSEH---------KALVSVVNSFHEKIVALEEKASQ 5097
Query: 1682 KKKI--DALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLD 1739
+K DA ++ ++ Q T L + Q LE + T V +A E +D
Sbjct: 5098 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5157
Query: 1740 KQCEMM---------KARHQELLSQQQNFILATQSAQAFLD----------QHGHNLTPE 1780
+ + + KA LL F+L + Q+ L Q G TP
Sbjct: 5158 QLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPG 5217
Query: 1781 EQQMLQQKLG-------ELKEQYSTSLAQSEAELKQ---VQTLQDELQKFLQDHKEF--- 1827
E+ L Q++ ++E+ T+ + ELK V+T + ++ ++Q+ KE+
Sbjct: 5218 EEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN 5277
Query: 1828 ------------ESWLERSEKELENMHKGGSSPET--------LPSLLKRQGSFSEDVIS 1867
+ L + +N+ K + LPS L Q +E +
Sbjct: 5278 PTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQ--LAEVAL- 5334
Query: 1868 HKGDLRFVTISGQKVLDMENSFKEGKEPS-EIGNLVKD------KLKDATERYTALHSKC 1920
DL+ K+ ++E S +E S +I L KD KLK T+ +
Sbjct: 5335 ---DLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQ 5391
Query: 1921 TRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL 1980
LG L D + + +A V+K L + ++ T+
Sbjct: 5392 KVLGEEL--------------DGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELH 5437
Query: 1981 QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSH----FQSLSYSLAER 2036
Q+ + + + + KL + A + E + +++ +L+H + S S L E+
Sbjct: 5438 QQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA--KVLAHGTIAWNSAS-QLREQ 5494
Query: 2037 SSLLQKAIAQSQSVQESLESLLQSIGEVEQ----NLEGKQVSSLSSGV--IQEALATNMK 2090
L Q + +S+ + LE++ + + + +QV+ L +++ + ++
Sbjct: 5495 YILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQ 5554
Query: 2091 LKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLK 2150
QD A+ EA + + +E A +T + G+L+ ++ +Q S ++
Sbjct: 5555 NLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS-----LKEQLSHRQHLLSEME 5609
Query: 2151 KLLPQAEMFEHLSGKLQ----------------QFMENKSRM--------------LASG 2180
L P+ + + L+ + E SR+ +
Sbjct: 5610 SLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY 5669
Query: 2181 NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2240
Q +Q++ H Q I+ + E+ED+ ++ L ++S +H++ Q +
Sbjct: 5670 EQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS---------RHEELAQKI--- 5717
Query: 2241 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2300
K +E+ +S + L K T + E EG TE + + L
Sbjct: 5718 -----KGYQEQIASLNSKCKMLTMKAKHA-TMLLTVTEVEGLAEGTE-DLDGELLPTPSA 5770
Query: 2301 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2360
H ++ TL+ + + + E EI++P + ++ S + + +SV Y+
Sbjct: 5771 HPSVVMMTAGRCHTLLSPVT-EESGEEGTNSEISSPPAC-RSPSPVANTDASVNQDIAYY 5828
Query: 2361 TCKDLTEIQCD--------------------------MSDVNLKYEKLGGVLHERQESLQ 2394
+Q D + D+ +E L V+ E+Q +L
Sbjct: 5829 QALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLY 5888
Query: 2395 AILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNS 2454
L R ++ S+ +E+ E L SP + ++Q ++A + E+
Sbjct: 5889 EALERQQKYQDSLQSISTKMEAIELKLSE-----SPEPGRSPESQMAEHQALMDEILMLQ 5943
Query: 2455 PKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR----------- 2503
+I +++ +LA LV+ + +Q L ER + + +
Sbjct: 5944 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6003
Query: 2504 QLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFE 2561
QLEE A ++ +L WL+ + + +P + AQ Q ML E E
Sbjct: 6004 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIE 6063
Query: 2562 ARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAI 2620
+ +L+ + +L G Q+ +L+ + +EL L+ + Q
Sbjct: 6064 QKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDK-----QLN 6118
Query: 2621 VKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKE 2680
++ T ++ D+ Q VQ ++ QQ + + + + +LEQ E+ E
Sbjct: 6119 MQGTAQEKEESDVD---LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQ---ELAE 6172
Query: 2681 AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMF 2740
++L ++ GE+ L ++ A G A ++ + L L +
Sbjct: 6173 QKSLLRSVASR-GEEIL-------IQHSAAETSGD---AGEKPDVLSQELGMEGEKSSAE 6221
Query: 2741 DELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLL 2800
D++R + + S K + LQ+ L++ +E +V+ + LL
Sbjct: 6222 DQMRMKWESLHQE------FSTKQKLLQNVLEQEQE------------QVLYSRPNRLLS 6263
Query: 2801 SVP------PGEEKRTLQNQLVELKNHWEELSKKT--ADRQSRLKDCMQKAQKYQWHVED 2852
VP P ++K + + L L +EE+S ++ A RQS + QK V
Sbjct: 6264 GVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS-----IHLEQKLYDGVSA 6318
Query: 2853 LVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSE 2912
W++D + ++ + L P + E+ L + + ++++ ++ + +
Sbjct: 6319 TSTWLDDVEERLF-VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENG 6377
Query: 2913 ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLE 2972
+ D I D + + + + + ++E Q++ FQ K + + K+ +
Sbjct: 6378 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII- 6436
Query: 2973 IFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAE 3032
Q +N + + Q E +Q E D L+ F G++E G L +
Sbjct: 6437 ------LQKLANVFEQPVAEQIEAIQQAE---DGLKEFDAGIIELKRRGDK----LQVEQ 6483
Query: 3033 VAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELD-GMGAIGRDTD 3091
+ QE +++ + +++ ++ G+ Q + L DL D L+ G + D
Sbjct: 6484 PSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQK 6543
Query: 3092 SLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLL---GLKRELE---ALNK 3145
+ S E+++ L+K +E+ HM+ E + +++E + L
Sbjct: 6544 IIVSSKEEIQQLLDKHKEYFQGLES------HMILTETLFRKIISFAVQKETQFHTELMA 6597
Query: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
Q + +R R +LE L E + + + + E E+ VG E ++
Sbjct: 6598 QASAVLKRAHKRGVELEYIL---ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRL 6654
Query: 3206 LADFKMFQ--KEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNK 3263
+ ++Q K ++ Q KL QV G+ L+ S LE + ++ W +
Sbjct: 6655 IDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTN 6710
Query: 3264 KVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVVKAQIQE 3319
K+++ + +L+ L H ++Q L+ WL ++ + S E ++V+ +
Sbjct: 6711 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNA 6770
Query: 3320 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379
+ +D + + + + G ++ + ++ D + +L ++S+WT+LL+ A Q+
Sbjct: 6771 FLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-DTATLRSELSRIDSQWTDLLTNIPAVQE 6829
Query: 3380 QLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP-----VGTQTAKIQQQIIRHKALEE 3434
+L + + + ++S+ E + E +G + I + + ++K +
Sbjct: 6830 KLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQKYKGFKI 6887
Query: 3435 DIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID------SLQARYSEIQDRCCRKAA 3488
DI V + QS+ ++S + S+K D ++ + +Q K
Sbjct: 6888 DINCKQLTVDF---VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 6944
Query: 3489 LLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNR 3548
LL+ L + + E+ V+ L E ++K + Q + D L + I +
Sbjct: 6945 LLEGLLESWSEY-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAK 7003
Query: 3549 KKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK 3608
+K V++ +NG AL++ + ++ L + +A++ + L+ +
Sbjct: 7004 EKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSS 7063
Query: 3609 FQSTYEELTGWLREVEEELAT----SGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV 3664
+ ++++ +L E L+ +G Q+ Q Q +L+K+ L
Sbjct: 7064 HKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKF 7119
Query: 3665 NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----Q 3720
++ LL+ E L + + N ++ + + I +++ A +Q Q+Y+ Q
Sbjct: 7120 GSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQ 7179
Query: 3721 AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 3780
A T L A + D+ +Q + KDS+ L ++
Sbjct: 7180 CASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQL 7239
Query: 3781 FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE 3840
+ +Q SL Q A+ ++ L+ + F ++ E L WI E
Sbjct: 7240 KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVE 7299
Query: 3841 TRALI-AQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM 3899
++ Q PS + D ++++ EE++ + P +D+L ++G +L LN +E
Sbjct: 7300 AEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP-LNDKE--- 7355
Query: 3900 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 3959
++ Q ++ I + +R L + Q F +K E +E L +L +
Sbjct: 7356 -IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQT---FLEKCETWMEFLVQTEQKLAVE 7411
Query: 3960 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4019
I + E ++ E+ Q ++ G+ L+ + Q D+D E K
Sbjct: 7412 --ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD----EFNLK 7465
Query: 4020 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4079
L + W+ + RA++R +++ + W + ++ V L G+
Sbjct: 7466 LTLLSNQWQGVIRRAQQRR----GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7521
Query: 4080 SIIKQQVEAAETIKEETDGLHEELEFIRILGA---------DLIFACGETEKPEVRKSID 4130
I Q A T+ +E +E F+R G+ L+ + + ++ +
Sbjct: 7522 VPIPLQ--QARTLFDEVQ--FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELA 7577
Query: 4131 EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNT 4190
E+ W++ + +E+ +KL ++ ++ + + D L+ L T
Sbjct: 7578 EIQEKWKSASMRLEEQKKKLAFLLK---DWEKCEKGIADSLEK--------------LRT 7620
Query: 4191 VKDQLNE-MKEFKVEVYQQQIEMEKLNHQ--------GELMLKKAT-----DETDRDIIR 4236
K +L++ + + E++ +Q+ ++L + +L L K T D I+
Sbjct: 7621 FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN 7680
Query: 4237 EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG 4296
E + L+ WE L +++ R+ ++ L F +EL WLT E + +G
Sbjct: 7681 ERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ----NG 7736
Query: 4297 DPKVIE-VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW 4355
D + E +E K + +A + ++ + + G L ++S AS + +L +N W
Sbjct: 7737 DILIEEMIEKLKKDYQEEIAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVNDRW 7795
Query: 4356 ESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT---GGLPETARE 4412
+ +L R ++L+ TL Q + L +ES+L+ KP E +
Sbjct: 7796 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQR 7853
Query: 4413 QLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE---QSVALLEQKWHVVS 4469
+L+ EL ++ +L+ ++L D + ++ + Q+ L+++W +
Sbjct: 7854 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7913
Query: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV 4529
+ ER+ K+EE L +F + F +WL +E++ S +I ++++ +
Sbjct: 7914 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 7973
Query: 4530 FANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLD 4589
F +V+ Q+ +++ +L ++ +K ++ RW+ + +R R L
Sbjct: 7974 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8033
Query: 4590 DARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPV 4649
+ ++F A ++ WL + + L + +E ++ D ++ ++ + K FQ+ +
Sbjct: 8034 HFIGQREEFETARDSILVWLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNK 8091
Query: 4650 YDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 4697
+ I G L EK+ P D+ ++ L E+R V G+ VER HK
Sbjct: 8092 IEQIIAQGEQLIEKS-EPLDAAIIEEELDELRRYCQEVFGR-VERYHK 8137
Score = 311 bits (797), Expect = 1e-83
Identities = 838/4723 (17%), Positives = 1813/4723 (38%), Gaps = 670/4723 (14%)
Query: 648 QNFHTSYAETLGKLETQYCKLKETSSFRMRHLQS--LHKFVSRATAELIWLNEKEEEELA 705
+N T ETL L+++ L E SS Q L K S A + L+E E+ +
Sbjct: 1178 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEK--ML 1235
Query: 706 YDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDT-----AELLSLENHPAKQTVEAY 760
++ D +N EL +E Q+ + DT A+ L L + + + A
Sbjct: 1236 SNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAK 1295
Query: 761 SAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTS 820
VQ Q+ +Q E + + R+LES L L+ S +R+
Sbjct: 1296 KRDVQQQIAQAQQ---------GEGGLPDRGHEELRKLESTLDGLERSRERQ-------- 1338
Query: 821 LSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYR 880
E +Q ++ + E+ +K +V + ++ + S + L + S++++
Sbjct: 1339 ----ERRIQVTLRKWERFETNKETVVRYLFQTGS-------SHERFLSFS-SLESLSSEL 1386
Query: 881 QIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSY 940
+ K E + K P G P NK ++ ++ +
Sbjct: 1387 EQTKEFSKRTESIAVQAENLVKEASEIPLG-------------PQNKQLLQQQAKSIKEQ 1433
Query: 941 QKVMALWHQLHVNTKSLIS--WNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYE 998
K + + + T ++ W++ + + + W EK + E ++Q
Sbjct: 1434 VKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQI 1493
Query: 999 DFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRL 1058
+S L S+ LEEE ++ F + + E+ K +++++
Sbjct: 1494 KVTIQEIESKLSSIVG---LEEEAQS----FAQFVTTGESAR-----IKAKLTQIRRYGE 1541
Query: 1059 RLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF 1118
L E+ Q + I +++Q+ +E+L++++ + K
Sbjct: 1542 ELREHAQCLEGTILG----------------HLSQQQKFEENLRKIQQSVSEFEDKLAVP 1585
Query: 1119 LHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEI 1178
+ S++ + E L + ++ + T + + V +Q+A L + YE
Sbjct: 1586 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYED 1645
Query: 1179 KLSQEEVVLADLSALEAHWSTLRHWLSD-------------------------VKDKNSV 1213
L + + L L AHW L LS V+ + +
Sbjct: 1646 ILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQL 1705
Query: 1214 FSVLDEEIAK-----AKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQS 1268
L E+ +K++ + S + D++ + QL ERW + +I
Sbjct: 1706 IQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLP---QIINK 1762
Query: 1269 ELESIQEVLGDYRACHGTLIK---WIE------ETTAQQEMMK-----------PGQAED 1308
+ +Q V+ +++ L+ WI+ +TT++ +M + E
Sbjct: 1763 RINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1822
Query: 1309 SRVLSEQLSQQTALFAEIERN------QTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVE 1362
+ + L A + R Q K + C + ++ S +V+ +L L F++
Sbjct: 1823 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQ 1882
Query: 1363 SQQKSPGKRRRMLSS-----------SDAITQEFMDLRTRYTALVTLTTQHVKYISDALR 1411
S G R++ + SD I ++ D AL + +S A
Sbjct: 1883 SHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQY 1942
Query: 1412 RLE----EEE---KVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAI 1464
L+ E+ + ++ VE+++ LLG + ++ A + K D ++ +
Sbjct: 1943 HLKIGSSEQRTSCRATADQLCGEVERIQNLLG-----TKQSEADALAVLKKAFQDQKEEL 1997
Query: 1465 LEQQVLSEELTTK---KEQVSEAIKTS-QIF------LAKHGHKL---SEKEKK------ 1505
L+ EE T K KE +A++ ++F L H H+L +K K+
Sbjct: 1998 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDV 2057
Query: 1506 ----QISEQLNALNKAYHDL----------CDGSAN---QLQQLQSQLAHQTEQKTLQKQ 1548
++ ++N L + D C G + + Q L+S ++ E +
Sbjct: 2058 AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIV 2117
Query: 1549 QNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL-----------SALQK-NQSDLKDLQ 1596
T + EDL W ++ A ++ Q+DL S L+K + SD ++
Sbjct: 2118 TRTTIKDQEDL-KWAF-SKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2175
Query: 1597 DDIQNRATSFATVVKDIEGFMEENQTKLSP-RELTALREKLH--------QAKEQYEALQ 1647
D+++ + V + +E M+ + LS ++ + R+++ Q E L
Sbjct: 2176 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2235
Query: 1648 EETRVAQ--KELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTN 1705
R + KE E V + + E +L E K ++ D + + + Q L +
Sbjct: 2236 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD-LQFIEADLMQKLEH 2294
Query: 1706 LPGMEQLSGASLEKGALDTTDGYMGVN-------QAPEKL-----DKQCEMMKAR---HQ 1750
+ +++ +L+ +T +N + E L ++ CE +K +
Sbjct: 2295 AKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2354
Query: 1751 ELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQV 1810
EL SQQ N I +TQ L + H+ E + + + G +K+ + S S+ +
Sbjct: 2355 ELQSQQSN-ISSTQENLNSLCRKYHSA--ELESLGRAMTGLIKKHEAVSQLCSKTQA--- 2408
Query: 1811 QTLQDELQK-FLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHK 1869
+LQ+ L+K F + +EF+ W ++ + + L + L + + V +
Sbjct: 2409 -SLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2467
Query: 1870 GDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNM 1929
L VT GQ + +I + +++++ A E + A +C + L
Sbjct: 2468 SKLDAVTQEGQTLY--------AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQD 2519
Query: 1930 LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQV 1989
+ F++ L W+ E E+ ++ + + E+ +++ L E
Sbjct: 2520 CASELGSFEDQHRKLNLWIHEME---ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLA 2576
Query: 1990 PVEKLQKVAR--DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQS 2047
E L K+++ ++ EG A + +L+ Q+L E+ Q A+ +
Sbjct: 2577 ARESLDKLSQRGQLLSEEGHGAGQEGRL---CSQLLTSHQNLLRMTKEKLRSCQVALQEH 2633
Query: 2048 QSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATRE 2107
++++E+L+S+ + ++ L + S+L S ++ L + QDI K E
Sbjct: 2634 EALEEALQSMWFWVKAIQDRLACAE-STLGS---KDTLEKRLSQIQDILLMKGEGEVKLN 2689
Query: 2108 MVT----RFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLS 2163
M + + +++ V+Q +L + + + + +S+L+ ++ Q +
Sbjct: 2690 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749
Query: 2164 GKLQQF------------------------MENKSRMLASGNQPDQDITHFFQQIQELNL 2199
+L+Q+ +++ +L+ + + + +EL
Sbjct: 2750 NQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE 2809
Query: 2200 EMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD----------FTELQKTVK 2249
+ ED+ E L T+ + + +V+ + KD FT+ + K
Sbjct: 2810 KTEDESFKDTAQEELKTQFNDIMTVAK--EKMRKVEEIVKDHLMYLDAVHEFTDWLHSAK 2867
Query: 2250 ER-------EKDASSCQEQLDEFRKLVRTFQ---KWLKETEGSIPPTETSMSAKELEKQI 2299
E D+S+ Q++L + ++L+ + + L E P + + +A E
Sbjct: 2868 EELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMH 2927
Query: 2300 EHLKSLLDDWAS-KGTLVEEINCKGTSLENLIMEITAPDSQ------------GKTGSIL 2346
+++L DW + ++ + +C LENL+ ++ + + + ++L
Sbjct: 2928 TEMQALRADWKQWEDSVFQTQSC----LENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2983
Query: 2347 PSVGSSVGSVNGYHTCKDLTE-------IQCDMSDVNLKYEKLGGVLHER---QESLQAI 2396
+ + + G +T +++ E I + + E L L+E L
Sbjct: 2984 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3043
Query: 2397 LNRMEEVHKEANSVL----QWLESKEEVLK--------------------SMDAMSSPTK 2432
++ + KE N + + ++KE++L+ + P
Sbjct: 3044 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3103
Query: 2433 TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWE 2492
V + + FL+E E K+ + LL T ++A+ + W+
Sbjct: 3104 ISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLTKEKAKGIQAKVTAAKEDWK 3162
Query: 2493 RATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQ 2552
++ LE + F+ + ++ WL + E M+ D ++Q+
Sbjct: 3163 NFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK 3222
Query: 2553 VQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSR 2612
+Q +L+E Q +L E AQ + G ++ + + ++ +++ L++ +
Sbjct: 3223 LQSVLEEIHCYEPQLNRLKEKAQQLWEGQA----ASKSFRHRVSQLSSQYLALSNLTKEK 3278
Query: 2613 SSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLE 2672
S++D+ + + Q+ +++L + + L P + K L+ + LE
Sbjct: 3279 VSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC----HPTSDKSVLDSRT---LKLE 3331
Query: 2673 QLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRIN-------R 2725
L VK+ + + ++ V GE L++ + + T+ LQ ++D+ A ++ +
Sbjct: 3332 AL-LSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQ 3390
Query: 2726 LQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHS 2785
L+ AL+ +Q + W+D ++ ++ A+L + L + + + + +S
Sbjct: 3391 LEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYS 3450
Query: 2786 GSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQK 2845
E I +G + E Q +L +L+ + + ++ + ++ + ++ Q+
Sbjct: 3451 SLLETIEVKGAGMT-------EHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQE 3503
Query: 2846 YQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS--KAMLNEVEKRRSLLEILNSA 2903
YQ ++ W+ + K+ + V + LR + ++ E + L +L++
Sbjct: 3504 YQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTR 3563
Query: 2904 ADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIE-- 2961
D++ + ED + + Q+ A L + +LR ++ F+ ++
Sbjct: 3564 EDVIPSGIPQAEDRALES---LRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEW 3620
Query: 2962 -KKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD 3020
K E K E+ +++ + V + Q L + Q L+
Sbjct: 3621 LKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL----- 3675
Query: 3021 GSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDEL 3080
Q+L Q + ++E +++ E+ L ++ + F +A D++
Sbjct: 3676 ----LQVLEQIKFLEEEIQSLEES--------ESSLSSYSDWYGSTHKNFKNVATKIDKV 3723
Query: 3081 DGMGAIGRDTDSLQSQIEDVRLFLNKIH-VLKLDIEASEAECRHMLEEEGTLDLLGLKRE 3139
D + +G+ +L+ ++D + K H +LK E E +++ EEG + L ++E
Sbjct: 3724 DTV-MMGKKLKTLEVLLKD----MEKGHSLLKSAREKGERAVKYL--EEGEAERL--RKE 3774
Query: 3140 LEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV 3199
+ +Q +LT + LE L ++F K K L AE E L ++
Sbjct: 3775 IHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQ--WIAEYQEILHVPEEPKM 3832
Query: 3200 EIINQ--QLADFKMFQ-----------------------------KEQVDPLQMKLQQVN 3228
E+ + QL+ +K Q K+++D LQ Q +
Sbjct: 3833 ELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLC 3892
Query: 3229 GLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKK------------------------ 3264
+G+ +++ ++ G E + + + +TL +
Sbjct: 3893 SIGKAMME------EIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 3946
Query: 3265 -----VAQRIAQ-LQEALLHCGKFQDALEPLLSWLADTE-ELIANQKPPSAEYKVVKAQI 3317
AQR+ Q L+ L QD L+ +WL+ + +L + +PP + + +K Q+
Sbjct: 3947 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIK-QV 4005
Query: 3318 QEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAAR 3377
+ + LQ + + +D+L + D + + + + + TE
Sbjct: 4006 KHFRALQ---EQARTYLDLL----------CSMCDLSNASVKTTAKDIQQTE-------- 4044
Query: 3378 QKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI- 3436
+ +E LV A+ + E I S L +++ ++Q RH LE +I
Sbjct: 4045 -QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQ------QLQNMKRRHSELELNIA 4097
Query: 3437 ENHATDVHQAVKIGQSLSSLTSPAEQGV--LSEKIDSLQAR-YSEIQDR---CCRKAALL 3490
+N + V VK QS + + + V L++K +S + + + + D+ CR++ L
Sbjct: 4098 QNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNL 4157
Query: 3491 ----DQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIV 3546
++ L R + + V +L + + ++ D + +H + LAL +
Sbjct: 4158 CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLAL--ALQ 4215
Query: 3547 NRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLA 3606
RK ++ Q +++ ++ L++E+ ++ R+ + + ++ +
Sbjct: 4216 ERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEEL 4275
Query: 3607 TKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNE 3666
QS ++EL W E + +A + QSP + + E+ +++L ++ +
Sbjct: 4276 NVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIK 4335
Query: 3667 VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAEL 3726
+ ++ + R+ + K +SDA +SD +GQR ++ A+ Q+ A
Sbjct: 4336 DADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQAT 4395
Query: 3727 AWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGE 3786
+ + + +RK+M I L D + Q++ K+ + +++ + L++ E+ E
Sbjct: 4396 SQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTE 4455
Query: 3787 EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIA 3846
++K+ + K + L Y+++ S R LE+ V F E +++ W+++ A I
Sbjct: 4456 QEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQ--ADIV 4513
Query: 3847 QLPSPAIDHE--QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ-LKELNPEEGEMVEEK 3903
P + +E +L Q + + + E E++ + L + G L LN + + EK
Sbjct: 4514 TFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEK 4573
Query: 3904 YQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIP 3963
+ I + + + EA+ E+ IE ++L L ++ +P
Sbjct: 4574 LNALPRQFNVIVALAKDKFYKVQEAILAR---KEYASLIELTTQSLSELEAQFLRMSKVP 4630
Query: 3964 AEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIG-RSQGADKDLAAKEIQDKLDQ 4022
++ + E +S L+++ EA+ ++ G RS G DK+
Sbjct: 4631 TDL-AVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ------PDKMLH 4683
Query: 4023 MVFFWEDIKARAEEREIKFLD---VLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4079
+V + +K + E+R D + EK + L ++K+ Q V++ P
Sbjct: 4684 LVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPA--- 4740
Query: 4080 SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENL 4139
+++++ ++ L+ + I DL + R I + L
Sbjct: 4741 ---EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLL 4797
Query: 4140 NKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMK 4199
E + + E M ++ +Q + DWL +K PV DLN ++D E++
Sbjct: 4798 TSAIGETVTECESRMVQSIDFQTEMSRSLDWLRR--VKAELSGPVYLDLN-LQDIQEEIR 4854
Query: 4200 EFKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIA 4254
K++++Q++++ M L+H+ + KA + D + L EL L ++ E +
Sbjct: 4855 --KIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISAD-LEHSLAELSELDGDIQEALR 4911
Query: 4255 HRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG---DPKVIEVELAKH--- 4308
RQ L ++ + WL +ELL ++G D + E L H
Sbjct: 4912 TRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQ----LAGNGLDVESAEENLKSHMEF 4967
Query: 4309 -------HVLKNDVLAHQATVETVNK-AGNELLESSAGDDASSLRS-RLEAMNQCWESVL 4359
H ++ + AT++ + K G E LE + LRS R+ + +L
Sbjct: 4968 FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVA--SLELRSQRMSRDSGAQVDLL 5025
Query: 4360 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4419
Q+ + Q ++ ++ E L E + +++ S A E+L H
Sbjct: 5026 QRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS---------HEAEEKLSEHKA 5076
Query: 4420 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKL 4479
L S + + E L +K + + +D+ S + +S+ + Q+W + + ++++ L
Sbjct: 5077 LVSVVNSFHEKIVALEEKASQLEKTGNDA-SKATLSRSMTTVWQRWTRLRAVAQDQEKIL 5135
Query: 4480 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 4539
E+A++ T F N +++ + + L +S +L+ +E H F
Sbjct: 5136 EDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTF--------- 5186
Query: 4540 QIIELDQTGNQLKFLSQKQDVVL-------------IKNLLVSVQSRWEKVVQRSIERGR 4586
++EL+Q + L L Q+ +L + + ++Q R + ++ G+
Sbjct: 5187 -VLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGK 5245
Query: 4587 SLDDARKRAKQFHEAWKKLIDWLEDAESHL-DSELEISNDPDKIKLQLSKHKEFQKTLGG 4645
+ K + + W+++ + +L + +EI +++++ L++ ++ +
Sbjct: 5246 LVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIE- 5304
Query: 4646 KQPVYDTTIRTGRALKEK-----TLLPED-SQKLDNFLGEVRDKWDTVCGKSVERQHKLE 4699
+ KEK T+LP + S +L +++ + D + K E +
Sbjct: 5305 ---------KMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIR-DQIQDKIKEVEQSKA 5354
Query: 4700 EALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGT 4759
+ S Q + L L K++ + D V+ KV +EL
Sbjct: 5355 TSQELSRQIQKLAKDLTTILTKLKAK----------TDNVVQAKTDQKVLGEELDGCNSK 5404
Query: 4760 VQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDT 4819
+ L + ++ +E + + ++ +L+ + + ++ S+L QA E + +
Sbjct: 5405 LMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEM 5464
Query: 4820 VHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVIL 4879
+ ++L+W+ +A + L + L+ H+ ++ E K +D + AM E +
Sbjct: 5465 LELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLE--ESKEID-SELEAMTEKLQ 5520
Query: 4880 AVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWA 4939
+ C + + + EE+ K Q L+ A ++ L++L A ++ A
Sbjct: 5521 YLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQA 5580
Query: 4940 ETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 4982
+ TL + + +K ++ Q + EM +P V V
Sbjct: 5581 QATLTSPEVGRL-----SLKEQLSHRQHLLSEMESLKPKVQAV 5618
Score = 303 bits (777), Expect = 2e-81
Identities = 850/4993 (17%), Positives = 1907/4993 (38%), Gaps = 680/4993 (13%)
Query: 311 EVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYI---HFKETEILAK 367
E +W++Y SR WI N +LK + + I + E + +
Sbjct: 1128 EDPDKWKDYTSRFSEFSSWIS------------TNETQLKGIKGEAIDTANHGEVKRAVE 1175
Query: 368 EREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLE 427
E G + L W++ L + N+ +++ +L L + + L
Sbjct: 1176 EIRNGVTKRGETL--SWLKSRLKVLTEVSSENEAQKQGDEL--------AKLSSSFKALV 1225
Query: 428 LLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQL 487
LL K+ + +C + + KN+L+ + + VQ +++ I+ + E L
Sbjct: 1226 TLLSEVEKMLSNFGDCVQYKEIVKNSLE---ELISGSKEVQEQAEKIL---DTENLFEAQ 1279
Query: 488 QVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTH 547
Q+ L + + + ++ + +Q ++ + L +GH +L STL
Sbjct: 1280 QLLL-----HHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKL--ESTLDGLE 1332
Query: 548 LKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERA- 606
E + + W R + +V + RF+ S +E + +LE+
Sbjct: 1333 RSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFL--SFSSLESLSSELEQTK 1390
Query: 607 EWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLE---T 663
E+ S+ +Q E S LG K+ + K S E + KLE
Sbjct: 1391 EFSKRTESIAVQAENLVK-EASEIPLGPQNKQLLQQQAK-------SIKEQVKKLEDTLE 1442
Query: 664 QYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFS 723
+ K E + H S + +S +W+ EKE+E A + S +S + + +
Sbjct: 1443 EDIKTMEMVKTKWDHFGSNFETLS------VWITEKEKELNALETS--SSAMDMQISQIK 1494
Query: 724 ELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVK 783
E+E K L++ A+ A+ SA ++++L +++ + +H +
Sbjct: 1495 VTIQEIESKLSSIVGLEEEAQSF------AQFVTTGESARIKAKLTQIRRYGEELREHAQ 1548
Query: 784 --ENTAYFQFFSDARELESFLRNLQDSI-----KRKYSCDHNTSLSRLEDLLQDSMDEKE 836
E T S ++ E LR +Q S+ K +S + +LQ+ MD +
Sbjct: 1549 CLEGT-ILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQ 1607
Query: 837 QLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLED 896
L S++ + ++ +V D CV E
Sbjct: 1608 ALESLSSAITAFSASARKVV-------------------------------NRDSCVQEA 1636
Query: 897 NSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKS 956
+ + ++ +D + A + + + ++A W +L S
Sbjct: 1637 AALQQQY-----------------------EDILRRAKERQTALENLLAHWQRLEKELSS 1673
Query: 957 LISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRL 1016
++W LE+ + A I ADR+
Sbjct: 1674 FLTW--------------LERGEAKASSPEMDIS----------------------ADRV 1697
Query: 1017 RLEEEVEACKARFQHLMK-----SMENEDKEETVAKMYISELKNIRLRLEEYEQR----- 1066
++E E++ +A ++ S + KE + ++K ++L LE+ ++R
Sbjct: 1698 KVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLP 1757
Query: 1067 --VVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPS 1124
+ KRI L S + + + L + Q S++ + + H+
Sbjct: 1758 QIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKD-H 1816
Query: 1125 SSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEE 1184
++ V + + EL L H+ L + L + + + ++ +D L + + + +
Sbjct: 1817 AAEVESKKGELQSL---QGHLAKLGS--LGRAEDLHLLQGKAEDCFQLFEEASQVVERRQ 1871
Query: 1185 VVLADLSA-LEAHWS---TLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNL 1240
+ L+ L+ L++H S LR V+ NS+ + I K A Q ++ +
Sbjct: 1872 LALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAV 1931
Query: 1241 DLERYQEKGSQLQERWHRVIAQLEIRQS----------ELESIQEVLGDYRACHGTL--- 1287
L+ G + ++H I E R S E+E IQ +LG ++ L
Sbjct: 1932 SLD-----GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVL 1986
Query: 1288 --------------IKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKL 1333
I+ IEE T ++ + +P + + L ++L L E+ ++ +L
Sbjct: 1987 KKAFQDQKEELLKSIEDIEERTDKERLKEPTR----QALQQRLRVFNQLEDELNSHEHEL 2042
Query: 1334 ----DQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLR 1389
D+ ++ +Q+ + + ++ + + ++ + + + +E+ +L+
Sbjct: 2043 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2102
Query: 1390 TRY--------TALVTLTT----QHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELL-- 1435
+ + +VT TT + +K+ + + +++ K K LL
Sbjct: 2103 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2162
Query: 1436 ---------GWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKE------- 1479
V T +T K K ++++ + + + L+T+ E
Sbjct: 2163 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2222
Query: 1480 ---QVSEAIKTSQIFL-AKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSAN-----QLQ 1530
Q++E I L A+ K E E K + +L L+ +DL + + N LQ
Sbjct: 2223 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQ 2282
Query: 1531 QLQSQLAHQTEQ------------KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTT 1578
+++ L + E K Q + + D+ +W + E +L
Sbjct: 2283 FIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL---MNCAQ 2339
Query: 1579 QQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEE---NQTKLSPRELTALREK 1635
+ AL+K +KD+Q ++Q++ ++ ++ +++ + + + R +T L +K
Sbjct: 2340 NETCEALKK----VKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2395
Query: 1636 LHQAKEQ---------YEALQEETRVAQKELEE---AVTSALQQETEKSKAAKELAENKK 1683
H+A Q E+L++ + +E +E +A ++ ++++ +K L
Sbjct: 2396 -HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2454
Query: 1684 KIDALLDWVT-------SVGSSGGQLLTNLPG------MEQLSGASLE-----------K 1719
+ +LD V+ +V G L +L EQ++ A+ E K
Sbjct: 2455 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2514
Query: 1720 GALDTTDGYMG-VNQAPEKLDKQCEMMKAR-HQELLSQQQNFI----------------- 1760
AL +G KL+ M+ R + E L + + I
Sbjct: 2515 QALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGEL 2574
Query: 1761 LATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTS----LAQSEAELKQVQTLQDE 1816
LA + + L Q G L+ E Q+ G L Q TS L ++ +L+ Q E
Sbjct: 2575 LAARESLDKLSQRGQLLSEEGHGAGQE--GRLCSQLLTSHQNLLRMTKEKLRSCQVALQE 2632
Query: 1817 LQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGD----L 1872
+ + + W++ + L S +TL L S +D++ KG+ L
Sbjct: 2633 HEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRL----SQIQDILLMKGEGEVKL 2688
Query: 1873 RFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLG 1932
G++ L N KEG+ +++ +L+ E + + S S L ++
Sbjct: 2689 NMAIGKGEQALRSSN--KEGQ------RVIQTQLETLKEVWADIMSSSVHAQSTLESVIS 2740
Query: 1933 QYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVE 1992
Q++ + + L+ WM++ + +E L PG L+E+ LQ L+E +
Sbjct: 2741 QWNDYVERKNQLEQWMESVDQKIEHPLQ----PQPG-LKEKFVLLDHLQSILSEAEDHTR 2795
Query: 1993 KLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQE 2052
L ++ E+ E D + + + F + E+ +++ + +
Sbjct: 2796 ALHRLIAKSRELY-EKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLD 2854
Query: 2053 SLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRF 2112
++ + ++ L S S Q+ L+ K+K+ I ++ + +
Sbjct: 2855 AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS---KIKELIDSREIGASRLSRVESLA 2911
Query: 2113 METADSTTAA-------VLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGK 2165
E +TTA+ +Q A+ Q + + Q E+ + ++ + F +
Sbjct: 2912 PEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQ 2971
Query: 2166 LQQFMENKSRMLAS---------GNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVT 2216
L+Q +E S +L + G D++I + + QE+ ++ + + L+ +
Sbjct: 2972 LEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLN 3031
Query: 2217 ELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL 2276
EL C F+ DL + +V L K++ L + ++ +Q FRK R FQ+WL
Sbjct: 3032 EL--CRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQ--RFRKAFRDFQQWL 3087
Query: 2277 KETEGSIPPT-ETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITA 2335
+ + + + E+ ++ ++ L + + + + KG L L +T
Sbjct: 3088 VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTL---LTK 3144
Query: 2336 PDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA 2395
++G IQ ++ ++ LH+++ +L+
Sbjct: 3145 EKAKG---------------------------IQAKVTAAKEDWKNFHSNLHQKESALEN 3177
Query: 2396 ILNRMEEVHKEANSVLQWLESKEEVL--KSMDAMSSPTKTETVKAQAESNKAFLAELEQN 2453
+ +M++ A + WL E+++ S P K + + + ++ L E+
Sbjct: 3178 LKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAK----RREQQKLQSVLEEIHCY 3233
Query: 2454 SPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLA 2513
P++ ++KE L + +++++ +L+S++ + +T + +L+ +
Sbjct: 3234 EPQLNRLKEKAQQL---WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHN 3290
Query: 2514 CFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEA 2573
F +L+ W+ + M+ + D ++L+++ +++ +L + + Q + +
Sbjct: 3291 QFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTR 3350
Query: 2574 AQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDL 2633
+ +L + T +Q++LQS+ W L SQ++ A+ K T YQ+ ++
Sbjct: 3351 GESVLQNTSPEGIPT--IQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQF 3408
Query: 2634 SEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVL-- 2691
S + ++ L+ + E +L + + + + L+ EV +L + + V
Sbjct: 3409 SGWMDSMEANLN-------ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGA 3461
Query: 2692 -IGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750
+ E Y+ + L+ + + +++ A + + + + + Q++Q+ WL +
Sbjct: 3462 GMTEHYV---TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQE 3518
Query: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810
Q + + + ++ L++ +E Q + ++ E ++ S P E R
Sbjct: 3519 QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRA 3578
Query: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 2870
L++ L+ W+ + ++ +++ + + K + + + + W++ + K VT
Sbjct: 3579 LES----LRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVT 3634
Query: 2871 LDPVQLESSLLRSKAMLNE--VEKRRS-------------LLEILNSAADI-----LINS 2910
++E R++ +L+E V R LL++L + +
Sbjct: 3635 AYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEE 3694
Query: 2911 SEADEDGIRDEKAGINQNMDAVTEELQ--------AKTGSLEEMTQRLREFQESFKNIEK 2962
SE+ D ++N V ++ K +LE + + + + K+ +
Sbjct: 3695 SESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSARE 3754
Query: 2963 KVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQ----ALEPQVDYLRNFTQGLVEDA 3018
K E A LE +A + + ++E+L+ ++ LE + + F+
Sbjct: 3755 KGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3814
Query: 3019 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLAD--- 3075
++ ++LH E + E E K +++ + + L VRE L +
Sbjct: 3815 QWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVK-SVREKGEALLELVQ 3873
Query: 3076 ---LDDELDGMGAIGRDTDSL-QSQIEDVRLFLNKIHVLKLDIEASEAEC----RHMLEE 3127
L D++D + + +D S+ ++ +E++ F ++++ L++ + +C + L++
Sbjct: 3874 DVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQ 3933
Query: 3128 EGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEE 3187
L G K A+ C ++ + +L+ + R + + L + +
Sbjct: 3934 NVHAHLQGTKDSYSAI---CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWL---SAVQPD 3987
Query: 3188 AEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGL 3247
E + E I +Q+ F+ Q++ L + L + L +++ K D+Q
Sbjct: 3988 LEPSPQPPLSRAEAI-KQVKHFRALQEQARTYLDL-LCSMCDLSNASVKTTAK--DIQQT 4043
Query: 3248 EHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPS 3307
E +E Q++ Q Q + + L +L D ++ + N K
Sbjct: 4044 EQTIE--------------QKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRH 4089
Query: 3308 AEYKVVKAQ--IQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLES 3365
+E ++ AQ + + K + L ++A+V+ + + ++ + E + ++I L
Sbjct: 4090 SELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEI----NHLND 4145
Query: 3366 RWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQ 3425
+W +L ++ Q E+ L + +H+ + FL + N ++ + +
Sbjct: 4146 QWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLE 4205
Query: 3426 IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3485
++ AL +A + + K Q + + ++ ++ E+ L+ R+ +++D R
Sbjct: 4206 ALKKLALALQERKYAIEDLKDQK--QKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR 4263
Query: 3486 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 3545
K + L + E++ W E + ++ + D+ DHLA+ E+
Sbjct: 4264 KIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSEL 4323
Query: 3546 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 3605
++ + IK+ ++ E +IQ+ L ++ ++ + + L +A
Sbjct: 4324 EAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSE 4383
Query: 3606 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVN 3665
T+F + T +++ E ++ + + + + K + + ++ + +
Sbjct: 4384 KTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLW 4443
Query: 3666 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAE 3725
R L++ V + + + + + Y V R+ E++ + + +++ D
Sbjct: 4444 AQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
Query: 3726 LAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSI--DIIRHKDSMDELFSHRSEIFGT 3783
W+ + ++ I L + + Q+ K +I +++ + L I +
Sbjct: 4504 CHWLKQA--DIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPS 4561
Query: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 3843
E + L EK +L +Q+ I L +++ +++ A + ++ E + + E A
Sbjct: 4562 LNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEA 4621
Query: 3844 LIAQLPSPAID--HEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVE 3901
++ D E+ Q+ R + + +A +D+L Q KE G+ +
Sbjct: 4622 QFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDEL----NQKKEGFRSTGQPWQ 4677
Query: 3902 -EKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPP 3960
+K +Y ++K + QR L++ S + + ++E L++++ S++
Sbjct: 4678 PDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEET 4737
Query: 3961 LIPAEVDKIRECISDN--------KSATVELEKLQPSFEALK-RRGEELIGRSQGADKDL 4011
L E K+ ++ + K T+ LE L P + L + I QG K L
Sbjct: 4738 LPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLL 4797
Query: 4012 AA------KEIQDKLDQMVFFWEDIKARAE-EREIKFLDVLELAEKFWYDMAALLTTIKD 4064
+ E + ++ Q + F ++ + R +K EL+ + D+ ++D
Sbjct: 4798 TSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVK----AELSGPVYLDL-----NLQD 4848
Query: 4065 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4124
Q+ + ++ I +++V+++ I H+E E +LI A +
Sbjct: 4849 IQEEIRKIQ-------IHQEEVQSSLRIMNALS--HKEKEKF-TKAKELISA-------D 4891
Query: 4125 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4184
+ S+ E++ ++ + + R L + +Y QA DWL++ +L +
Sbjct: 4892 LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGN 4950
Query: 4185 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4244
G D+ + ++ L EF Q +E+L H L T ++ + + + L+
Sbjct: 4951 GLDVESAEENLKSHMEFFSTEDQFHSNLEEL-HSLVATLDPLIKPTGKEDLEQKVASLEL 5009
Query: 4245 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPI-SGDPKVIEV 4303
+ + + L+ +Q A EE++ + TE+ L + + E
Sbjct: 5010 RSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEE 5069
Query: 4304 ELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDAS--SLRSRLEAMNQCWESVLQK 4361
+L++H L + V + + + + ++L G+DAS +L + + Q W +
Sbjct: 5070 KLSEHKALVSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRSMTTVWQRWTRLRAV 5127
Query: 4362 TEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY 4421
+++E+ L+ + + GF+++++ + T M QL P + ++ +L T +E +
Sbjct: 5128 AQDQEKILEDAVDEWTGFNNKVK----KATEMIDQLQDKLPGSSAEKASKAELLTLLEYH 5183
Query: 4422 SQLKAKEETYNQLLDKGRLMLLSRDDSGSG------SKTEQSVALLEQKWHVVSSKMEER 4475
+ E L R LS G+ Q + ++ + + K++
Sbjct: 5184 DTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTN 5243
Query: 4476 KSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVN 4535
+++ L + + W+ +++ P++ ++ +Q+EE ++ E
Sbjct: 5244 GKLVKQELKDREMVETQINSVKCWV---QETKEYLGNPTIEID---AQLEELQILLTEAT 5297
Query: 4536 AHRDQIIELDQTGNQLKFLS-----------QKQDVVLIKNLLVSVQSRWEKVVQRSIER 4584
HR I ++ + + K+L Q +V L + +Q + ++V Q
Sbjct: 5298 NHRQNIEKMAEEQKE-KYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQ----- 5351
Query: 4585 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 4644
S +++ ++Q + K L L ++ D+ ++ D QK LG
Sbjct: 5352 --SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD--------------QKVLG 5395
Query: 4645 GKQPVYDTTIRTGRALKEKTLLPED--SQKLDNFLGEVRDKWDTVCGKSVERQHKLEEAL 4702
+ ++ + A +K L + L +G++ + ++ R KL +A
Sbjct: 5396 EELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAA 5455
Query: 4703 LFSGQFMDALQALVDWLYKVE------------PQLAEDQPVHGDLDLVMNLMDAHKVFQ 4750
++ + L+ ++ W+ K + QL E +H L++ K
Sbjct: 5456 SHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILH------QTLLEESKEID 5509
Query: 4751 KELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQAL 4810
EL T +Q L S T + Q+ EL + + ++ + L+ A
Sbjct: 5510 SELEAMTEKLQYL---------TSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAA 5560
Query: 4811 KQAEVFRDTVHMLLEWLSEAEQTLRF----RGALPDDTEALQSLIDTHKEFMKKVEEKRV 4866
K + F + L L +A+ TL R +L + Q L+ + KV+ ++
Sbjct: 5561 KDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQL 5620
Query: 4867 DVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANA 4926
SA+ + E ++A P C ++ ++ + A Q ++ A+ +
Sbjct: 5621 -CQSALRIPEDVVASL-PLCHAALR-----LQEEASRLQHTAIQQCNIMQAAVVQYEQYE 5673
Query: 4927 ELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTY 4986
+ ++ L I+ A + D+ NI ++A I+ H+ +++ Q + +
Sbjct: 5674 QEMKHLQQLIEGAHREI--EDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKC 5731
Query: 4987 KRKNIEPTHAPFI 4999
K ++ HA +
Sbjct: 5732 KMLTMKAKHATML 5744
Score = 281 bits (719), Expect = 1e-74
Identities = 692/3836 (18%), Positives = 1483/3836 (38%), Gaps = 428/3836 (11%)
Query: 1204 LSDVKDKNSVFSVLDEEIAKAKVVAEQMS-----RLTPERNLDLERYQEKGSQLQERWHR 1258
L D++++ + EE+ + + +S + T + L + ++L E
Sbjct: 4846 LQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGD 4905
Query: 1259 VIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQ 1318
+ L RQ+ L I Y W+E+ AQ+ + G D E L
Sbjct: 4906 IQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED--AQELLQLAGNGLDVESAEENLKS 4963
Query: 1319 QTALFAEIERNQTKLDQCQKFSQQYSTIVK-----DYELQLMTYKAFVESQQKSPGKRRR 1373
F+ ++ + L++ ++K D E ++ + + + + G +
Sbjct: 4964 HMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVD 5023
Query: 1374 MLSSSDAITQEFMDLRTRYTALVTLTTQHVKYIS--------DALRRLEEEEKVVEEEKQ 1425
+L A ++ R L+ T + + S +A +L E + +V
Sbjct: 5024 LLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNS 5083
Query: 1426 EHVEKVKELLGWVSTLAR--NTQGKATSSETKES-----TDIEKAILEQQVLSEELTTKK 1478
H EK+ L S L + N KAT S + + T + +Q+ + E+ +
Sbjct: 5084 FH-EKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEW 5142
Query: 1479 EQVSEAIKTSQIFLAKHGHKL--SEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQL 1536
+ +K + + + KL S EK +E L L YHD Q Q L
Sbjct: 5143 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLE--YHDTFVLELEQQQSALGML 5200
Query: 1537 AHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQ-----GRTTQQDLSALQKNQSD 1591
QT T ++ + +R L + G+ +Q+L + ++
Sbjct: 5201 RQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQ 5260
Query: 1592 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQ--------Y 1643
+ ++ +Q +I+ +EE Q L+ E T R+ + + E+ Y
Sbjct: 5261 INSVKCWVQETKEYLGNPTIEIDAQLEELQILLT--EATNHRQNIEKMAEEQKEKYLGLY 5318
Query: 1644 EALQEET--RVAQKELEEAVTSALQ---QETEKSKA-----AKELAENKKKIDALLDWVT 1693
L E ++A+ L+ + +Q +E E+SKA ++++ + K + +L +
Sbjct: 5319 TILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLK 5378
Query: 1694 SVGSSGGQLLTNLPGM-EQLSGASLEKGALDTT-DGYMGVN-QAPEKLDKQCEMMKARHQ 1750
+ + Q T+ + E+L G + + LD ++ N Q + L K+ + HQ
Sbjct: 5379 AKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQ 5438
Query: 1751 ELLSQQQNFILATQSAQAFLDQ-------------------HG----------------H 1775
+ + Q +N + A + L++ HG H
Sbjct: 5439 QTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILH 5498
Query: 1776 NLTPEEQQMLQQKLGELKE--QYSTSLAQSEAELKQVQTLQDE--------------LQK 1819
EE + + +L + E QY TS+ +E +QV L E LQ
Sbjct: 5499 QTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQD 5558
Query: 1820 FLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISG 1879
+D K+FE+ L++ + LE +SPE LK Q S + ++S L+
Sbjct: 5559 AAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV--- 5615
Query: 1880 QKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN 1939
Q V +++ + ++ L L+ E H+ + + + QY Q++
Sbjct: 5616 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI-MQAAVVQYEQYEQ 5674
Query: 1940 SADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 1999
LQ ++ +E S+ LQ Q++ ++L +++ +Q + L +
Sbjct: 5675 EMKHLQQLIEGAHREIED--KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCK 5732
Query: 2000 DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLES-LL 2058
++ ++ + A V E + + + L L S + + +L S +
Sbjct: 5733 -MLTMKAKHATMLLTVTEV-EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5790
Query: 2059 QSIGEVEQNLE---------GKQVSSLSSGVIQE-----ALATNMKLKQDIARQKSSLEA 2104
+ GE N E V++ + V Q+ AL+ +L+ D A+ S A
Sbjct: 5791 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAE-RLQTDAAKIHPSTSA 5849
Query: 2105 TREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH--- 2161
++E +E S TA KL ++ + +E L EK+ +L + L + + ++
Sbjct: 5850 SQEFYEPGLEP--SATA-----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQ 5902
Query: 2162 -LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL-EHLVTELS 2219
+S K++ S G P+ + + E+ + ++ E +L E LV+E
Sbjct: 5903 SISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESC 5962
Query: 2220 SCGFALDLCQHQ------DRVQNLRKDFTELQKTVKEREKDASSCQEQ---LDEFRKLVR 2270
A L +R+ +R + ++ ++E+ D Q Q L +R
Sbjct: 5963 EADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEAD 6022
Query: 2271 TFQKWLKETEGSI-----PPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTS 2325
WL T+ ++ PP E ++E Q+ +++L + K + E++
Sbjct: 6023 ELDSWLLSTKATLDTALSPPKEPM----DMEAQLMDCQNMLVEIEQKVVALSELSVHN-- 6076
Query: 2326 LENLIME---ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL----TEIQCDMSDVNLK 2378
ENL++E T +++ G + GS + H K L T + + SDV+L
Sbjct: 6077 -ENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD-KQLNMQGTAQEKEESDVDLT 6134
Query: 2379 YEKLGGV-----------LHERQESLQAILNRMEEVHKEANSVLQWLESK-EEVLKSMDA 2426
+ GV +RQ SLQ +E+ E S+L+ + S+ EE+L A
Sbjct: 6135 ATQSPGVQEWLAQARTTWTQQRQSSLQQ-QKELEQELAEQKSLLRSVASRGEEILIQHSA 6193
Query: 2427 MSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEE 2486
ET E EL K + Q W+ + +E
Sbjct: 6194 ------AETSGDAGEKPDVLSQELGMEGEK-------------SSAEDQMRMKWESLHQE 6234
Query: 2487 LNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLS-----I 2541
+++ + V Q Q+ S + + +K + +L L+ +
Sbjct: 6235 FSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV 6294
Query: 2542 DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQK 2601
A++Q + K ++ L++ + + + T + + +
Sbjct: 6295 SSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKD 6354
Query: 2602 WVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQL 2661
E++++++ + QA ++ +++++D + +G+ + S ++ + +K++L
Sbjct: 6355 IKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL--LGRLSLLDSVVNQRCHQMKERL 6412
Query: 2662 EETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAA- 2720
++ ++DL+ L + + + + + + EQ + +++ E + GL++ A
Sbjct: 6413 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI----EAIQQAEDGLKEFDAG 6468
Query: 2721 --------DRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQ 2772
D++ Q ++ + Q M+DEL + ++S +N + ++ ER L
Sbjct: 6469 IIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLA 6528
Query: 2773 ENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEE-----------KRTLQNQLV----- 2816
+ E + + +G ++IV+ E + + +E TL +++
Sbjct: 6529 DLLETGQE--KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQ 6586
Query: 2817 -ELKNHWEELSKKTA----------------DRQSRLKDCMQKAQKYQWHVEDLVPWIED 2859
E + H E +++ +A + S L + Q+ + VE +P +
Sbjct: 6587 KETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGL 6646
Query: 2860 CKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIR 2919
+ L +D + L L K+ LNE + + L ++L+ +LI+ S +D +
Sbjct: 6647 VEENEDRL---IDRITLYQHL---KSSLNEYQPK--LYQVLDDGKRLLISISCSD---LE 6695
Query: 2920 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGS 2979
+ + + + T ++ + LE + + +Q ++ ++ AK +LE +
Sbjct: 6696 SQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ--Q 6753
Query: 2980 QACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL 3039
+ LE +R +VD + ++ S +QLL +V
Sbjct: 6754 SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVL------STGNQLLRLKKVDTATLR 6807
Query: 3040 EVKQRVNS-------GCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDS 3092
R++S ++ KL + R S++ ++ + I +D D+
Sbjct: 6808 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV--IQKDEDN 6865
Query: 3093 LQSQI--EDVRLFLNKIHVLKLDIEASEAECRHMLE----------EEGTLDLLGLKREL 3140
+++ I + + +L K K+DI + + + E D +L
Sbjct: 6866 IKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQL 6925
Query: 3141 EALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVE 3200
A+NK L + + LE L ++ ++ L E+ Q +G +
Sbjct: 6926 GAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQAS 6985
Query: 3201 IIN-----QQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEIN 3255
+ N Q L D ++++V+ ++ NGL LIQ+ +D + + E+
Sbjct: 6986 VQNALKDCQDLEDLIKAKEKEVEKIEQ-----NGLA--LIQNKKEDVSSIVMS-TLRELG 7037
Query: 3256 ARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKA 3315
W L+ V Q L+ L + A + + S+L + ++ + + + V+
Sbjct: 7038 QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQV 7097
Query: 3316 QIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAA 3375
Q+ + LQ L+ ++ ++ + ++ + E +T L+ + RW LL + A
Sbjct: 7098 QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIA 7157
Query: 3376 ARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEED 3435
+ + + +L L +++ + ++ + + E + T ++ D
Sbjct: 7158 EQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND 7217
Query: 3436 IENHATDVHQAV----KIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLD 3491
+ V ++ ++G+ L + + SL ++ C++ L
Sbjct: 7218 LLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQ 7277
Query: 3492 QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKN 3551
+ + F + + W+ E E+ L QD H +D + E + K
Sbjct: 7278 AGVLDYETFAKSLEALEAWIVEAEEILQG-------QDPSHS--SDLSTIQERMEELKGQ 7328
Query: 3552 VDQAIKNGQALLK-QTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQ 3610
+ + L + G + L +++ ++ ++ SS+ + + + Q
Sbjct: 7329 MLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQ 7388
Query: 3611 STYEELTGWLR---EVEEELAT--SGGQSPTGEQIPQFQQRQKEL-KKEVMEHRLVLDTV 3664
+ E+ W+ + E++LA SG EQ QR EL + E+ + +L ++
Sbjct: 7389 TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ-----QRAHELFQAEMFSRQQILHSI 7443
Query: 3665 NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADA 3724
+ LLE R+ + ++ + Q++ V QR ID+ I++ Q+Y + A+
Sbjct: 7444 IIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEK 7503
Query: 3725 ELAWVAETKRKLMA-LG--PIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIF 3781
W+ E M+ LG PI L+Q +T +VQ + +R + S ++
Sbjct: 7504 LRKWLVEVSYLPMSGLGSVPIPLQQARTLFD-EVQFKEKV-FLRQQGSYILTVEAGKQLL 7561
Query: 3782 GTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE-LSPWIEE 3840
+ + LQ + + +++++ S+ E+ +L + + WE E+ ++ +E+
Sbjct: 7562 LSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL----AFLLKDWEKCEKGIADSLEK 7617
Query: 3841 TRALIAQLPSPAIDH-EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE-LNPEEGE 3898
R +L DH E+L +Q ++L ++ + +L + L ++ ++
Sbjct: 7618 LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDIS 7677
Query: 3899 MVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRM 3958
++ E+ + + + ++ ++ R + E +++ F +K + + E L + S++
Sbjct: 7678 ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV---FSEKNKELCEWLTQMESKVSQ 7734
Query: 3959 PP--LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEI 4016
LI ++K+++ + + A + K+Q L++ GE L S + A EI
Sbjct: 7735 NGDILIEEMIEKLKKDYQE-EIAIAQENKIQ-----LQQMGERLAKASH----ESKASEI 7784
Query: 4017 QDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQD-----IVHD 4071
+ KL ++ W+ + R K + L ++ +M++L T + + IV+D
Sbjct: 7785 EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 7844
Query: 4072 LESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDE 4131
+ + +Q E I++ + G+ L +L D + E ++++
Sbjct: 7845 SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 7904
Query: 4132 MNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTV 4191
++ W N+ ER K+E+ + ++ D DWL ++ G
Sbjct: 7905 LDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 7964
Query: 4192 KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDI-IREPLTELKHLWENLG 4250
K++L + + F+ +V++ ++E +N Q + ++ + TD +++ + E W+NL
Sbjct: 7965 KEELKKFEAFQRQVHECLTQLELINKQYRRLARE--NRTDSACSLKQMVHEGNQRWDNLQ 8022
Query: 4251 EKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE-ELLDAQRPISGDPKVIEVELAKHH 4309
+++ +L+ + +F+ A + ++ WLT + +L + + D ++ ++ +
Sbjct: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD---VQAKIKQLK 8079
Query: 4310 VLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQL 4369
+ ++ + +E + G +L+E S DA+ + L+ + + + V + E ++L
Sbjct: 8080 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 8139
Query: 4370 QSTLQQAQGFHSEIEDFLLEL------------TRMESQLSASKPTGGLP-------ETA 4410
L H ++ D LEL R L + +P+ L +
Sbjct: 8140 -IRLPLPDDEH-DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 8197
Query: 4411 REQLDTHMELYSQLKAKEETYNQLLDKGRLM---LLSRDDSGSGSKTEQSVALLEQKWHV 4467
R DT + S + Y+ D M L S D+ G K + +
Sbjct: 8198 RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM 8257
Query: 4468 VSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLA--------EQSLNIASPPSLILNT 4519
+ E E A+ + ++L+ I L A +Q+ NI +
Sbjct: 8258 IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 8317
Query: 4520 VLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL------LVSVQSR 4573
+ + + + E ++ D + L+ K +++ + NL V R
Sbjct: 8318 LDTSYKGYMKLLGECSSSIDSVKRLEH-----KLKEEEESLPGFVNLHSTETQTAGVIDR 8372
Query: 4574 WEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD--SELEISNDPDKIKL 4631
WE + +++ + + ++ +QF+ + WL D E L+ LE+S D I+L
Sbjct: 8373 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8432
Query: 4632 QLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKS 4691
Q+ K KE QK + ++ + + + ++S+ L + L ++ +WD VC
Sbjct: 8433 QIKKLKELQKAVDHRKAIILSINLCSPEFTQAD--SKESRDLQDRLSQMNGRWDRVCSLL 8490
Query: 4692 VERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHK 4747
E + L++AL+ F + L+ L ++ + E P+ +LD + L D HK
Sbjct: 8491 EEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI-LQDHHK 8545
Score = 275 bits (702), Expect = 1e-72
Identities = 788/4143 (19%), Positives = 1625/4143 (39%), Gaps = 506/4143 (12%)
Query: 675 RMRHLQSLHKFVSRATAELIWLNE------KEEEELAYDWSDNNSNISAKRNYFSELTME 728
+M HL +L+ + R T + + L E +E E++ ++ +++ +E T+
Sbjct: 4680 KMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLP 4739
Query: 729 LEEKQDVFRSL----QD--------TAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCL 776
EEK ++ SL QD T L L H E +QS +K L
Sbjct: 4740 AEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTS 4799
Query: 777 CVEQHVKENTAYF----QFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSM 832
+ + V E + F ++ +LR ++ + D N L +++ ++
Sbjct: 4800 AIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLN--LQDIQEEIRKIQ 4857
Query: 833 DEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDEC 892
+E++ S + +L + K L+++++ + D I+ +
Sbjct: 4858 IHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD-GDIQEALRTRQAT 4916
Query: 893 VLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHV 952
+ E SQ ++ + N+ + + L N +E A +S+ + + Q H
Sbjct: 4917 LTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHS 4976
Query: 953 NTKSLISWNYLRKDL-------DLVQTWNLEKLRSSA----PGECHQIMKNLQAHYEDFL 1001
N + L S L DL Q +LRS G +++ A + D+
Sbjct: 4977 NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY- 5035
Query: 1002 QDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLE 1061
Q +R+ V+ + D + E K H E + E ++ + LE
Sbjct: 5036 QKAREEVIELMNDTEKKLSEFSLLKTSSSH---EAEEKLSEHKALVSVVNSFHEKIVALE 5092
Query: 1062 EYEQRVVKRIQSLAS---SRTDRDAWQD-NALRIAEQEHTQ------EDLQQLRSDLDAV 1111
E ++ K + SR+ WQ LR Q+ + ++ + +
Sbjct: 5093 EKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKA 5152
Query: 1112 SMKCDSFLHQSPSSSSVPTLRSELNLLVEKMD-HVYGL----STVYLNKLKTVDVIVRSI 1166
+ D + P SS+ ++EL L+E D V L S + + + +T+ ++
Sbjct: 5153 TEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSML---- 5208
Query: 1167 QDAELLVKGYEIKLSQEEVVLAD--LSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKA 1224
QD G E L QE + D L+ E + + ++KD+ V + ++
Sbjct: 5209 QDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWV 5268
Query: 1225 KVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACH 1284
+ E + T E + LE Q ++ + E E ++ LG Y
Sbjct: 5269 QETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAE------EQKEKYLGLYTILP 5322
Query: 1285 GTLIKWIEETTAQQEMM-----KPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKF 1339
L + E ++ K + E S+ S++LS+Q QK
Sbjct: 5323 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQI----------------QKL 5366
Query: 1340 SQQYSTIVKDYELQLMTYKAF-VESQQKSPGKR----RRMLSSSDAITQEFMD------- 1387
++ +TI+ +L+ T ++ QK G+ L DA Q+F++
Sbjct: 5367 AKDLTTILT--KLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGK 5424
Query: 1388 -LRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVS---TLAR 1443
L + L L Q ++ + L +L + +EE + E ++ +L W+ LA
Sbjct: 5425 PLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE----YNEMLELILKWIEKAKVLAH 5480
Query: 1444 NTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIK--TSQIFLAKHGHKLSE 1501
T ++S+ +E + + +LE+ S+E+ ++ E ++E ++ TS K +++E
Sbjct: 5481 GTIAWNSASQLREQYILHQTLLEE---SKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5537
Query: 1502 KEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCS 1561
++ +E+L + K +A +++ +++L + Q L++ Q T S
Sbjct: 5538 LGRE--TEELRQMIKIRLQNLQDAAKDMKKFEAEL--KKLQAALEQAQATLTSPEVGRLS 5593
Query: 1562 WVGQ-AERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN 1620
Q + R + + + + A+Q QS L+ +D + + A + E ++
Sbjct: 5594 LKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQH 5653
Query: 1621 QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEE--AVTSALQQETEKSKAAKEL 1678
+ A + Q +++ + LQ+ A +E+E+ TS +Q+ + +EL
Sbjct: 5654 TAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEEL 5713
Query: 1679 AENKK-------KIDALLDWVTSVGSSGGQLLTNLP------GMEQLSGASLEKGALDTT 1725
A+ K +++ +T LLT G E L G L + +
Sbjct: 5714 AQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPS 5773
Query: 1726 -------------------DGYMGVN---------QAPEKL---DKQCEMMKARHQELLS 1754
G G N ++P + D A +Q L +
Sbjct: 5774 VVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSA 5833
Query: 1755 QQQNFILA-----TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ 1809
++ A T ++Q F + P + KLG+L+ + T + +
Sbjct: 5834 ERLQTDAAKIHPSTSASQEFYE-------PGLEPSATAKLGDLQRSWETLKNVISEKQRT 5886
Query: 1810 VQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHK 1869
+ + QK+ + + +E E +L + G SPE S + + ++++ +
Sbjct: 5887 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILMLQ 5943
Query: 1870 GDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTR----LGS 1925
++ + S + L E+ + E + + L ER + + K + L
Sbjct: 5944 DEINELQSSLAEELVSESCEADPAEQLAL----QSTLTVLAERMSTIRMKASGKRQLLEE 5999
Query: 1926 HLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQ 1979
LN L + Q ++ AD L +W+ + +A ++ LS +P ++ QL +
Sbjct: 6000 KLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQN 6057
Query: 1980 LQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE-RSS 2038
+ E+ + V + +L V + + +EG+ H ++ + + + L SL E + +
Sbjct: 6058 MLVEIEQKVVALSELS-VHNENLLLEGKA-----HTKDEAEQLAGKLRRLKGSLLELQRA 6111
Query: 2039 LLQKAIAQSQSVQESLES-----LLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQ 2093
L K + + QE ES QS G E + + + Q +L +L+Q
Sbjct: 6112 LHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQR---QSSLQQQKELEQ 6168
Query: 2094 DIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLL 2153
++A QKS L R + +R E +AA G E Q + EK S+ ++
Sbjct: 6169 ELAEQKSLL---RSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6225
Query: 2154 PQAE-MFEHLSGK---LQQFMENKSRM--------------LASGNQPDQDITHFFQQIQ 2195
+ E + + S K LQ +E + L G+ P QD + +
Sbjct: 6226 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLD 6285
Query: 2196 ELNLEMED--------QQENLDTLEHLVTELSSCGFALDLCQHQDRVQN-LRKDFTELQK 2246
LN E+ +++++ + L +S+ LD + + V L + TE
Sbjct: 6286 GLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCL 6345
Query: 2247 TVKE-REKDASSCQEQLDEFRKLVRTF-------QKWLKETEG------SIPPTETSMSA 2292
+E KD E++D+ + L + +++T G S+ + +
Sbjct: 6346 FNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRC 6405
Query: 2293 KELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSLENLIMEITAPDSQGKTGSILP 2347
+++++++ + + +D T + + + E + E Q + G
Sbjct: 6406 HQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEF 6465
Query: 2348 SVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2407
G G + +Q ++S + Y++L ++ R+ L L + +
Sbjct: 6466 DAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERAL 6524
Query: 2408 NSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL 2467
+ LE+ +E + + +K E ++ + +K + LE + + E L
Sbjct: 6525 QDLADLLETGQEKMAGDQKIIVSSKEE-IQQLLDKHKEYFQGLESH----MILTETLFRK 6579
Query: 2468 LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 2527
++++ +E + ++ + ++ +RA + V + LE + SHL + +L L
Sbjct: 6580 IISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE-TWSHL---DEDQQELSRQLE 6635
Query: 2528 EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 2587
E + +G + + + L + Q + + + Q+ + + +L +S+S
Sbjct: 6636 VVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLL-----ISIS 6690
Query: 2588 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 2647
S ++ +L + + W+ T+K++ +++ + T+YQ DL +++ RL
Sbjct: 6691 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6750
Query: 2648 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 2707
+ Q V Q+LE + + + EV +AQ+ + G Q L+ K+++T
Sbjct: 6751 TQ---QSVTVPQELEMVRDHLNAFLEFSKEV-DAQSSLKSSVLSTGNQLLR---LKKVDT 6803
Query: 2708 VAL--PLQGLEDLAADRINRLQAALASTQQFQQ-------MFDELRTWLDDKQSQQAK-- 2756
L L ++ D + + A Q Q E+ +W+ ++ K
Sbjct: 6804 ATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDE 6863
Query: 2757 -NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-LSVPPGEEKRT---- 2810
N S + + LQ+ + F+ +N + + + +S+L +S E KR+
Sbjct: 6864 DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFV---NQSVLQISSQDVESKRSDKTD 6920
Query: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 2870
QL + W+ L ++ L+ ++ +Y+ +V+ L W E + ++ +
Sbjct: 6921 FAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRI 6980
Query: 2871 LDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMD 2930
D ++++L + + + ++ + +E + LI + + D I +
Sbjct: 6981 GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI----------VM 7030
Query: 2931 AVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNK-NLEK 2989
+ EL +L+ M +L+ +S + + + H++ FD + S + +L +
Sbjct: 7031 STLRELGQTWANLDHMVGQLKILLKSVLD-----QWSSHKVA-FDKINSYLMEARYSLSR 7084
Query: 2990 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVAQQEFL-----E 3040
R L+A++ QVD L+N L + GS +QLL + E L E
Sbjct: 7085 FRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKE 7144
Query: 3041 VKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDV 3100
V R N+ ++E E + Q + +++ + D + S Q ED
Sbjct: 7145 VNMRWNN---LLEEIAEQL-QSSKALLQLWQRYKDYS----------KQCASTVQQQEDR 7190
Query: 3101 RLFLNKIHVLKLDIEASEA-----ECRHMLEEEGTL-DLLGLKRELEALNKQCGKLTERG 3154
L K K DI E +C +L+ GT+ D L EL KQ +
Sbjct: 7191 TNELLKAATNK-DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7249
Query: 3155 KARQEQLELT--LGRVEDFYRKLK-----GLNDATTAAEEAEALQ-WVVGTEVEIINQQ- 3205
+ +QL L+ L +E K + G+ D T A+ EAL+ W+V E EI+ Q
Sbjct: 7250 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE-EILQGQD 7308
Query: 3206 ---LADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDVQGLE-HDMEEINARWN 3259
+D Q E+++ L+ ++ + + + L + G + E M+ +N W+
Sbjct: 7309 PSHSSDLSTIQ-ERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWS 7367
Query: 3260 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQE 3319
++ + +R ++LQ LL F + E + +L TE+ +A + S Y+ + Q +
Sbjct: 7368 LISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SGNYQHLLEQQRA 7425
Query: 3320 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379
+L Q + R+ + + +G R+ + ++ DR++ +L L ++W ++ +A R+
Sbjct: 7426 HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRG 7485
Query: 3380 QLEDILVLAKQFHETAEPISDFL---SVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3436
++ + +++ E AE + +L S S P+ Q A+ ++ K E+
Sbjct: 7486 IIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFK--EKVF 7543
Query: 3437 ENHATDVHQAVKIG-QSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495
V+ G Q L S S AE +LQA +EIQ++ + L++
Sbjct: 7544 LRQQGSYILTVEAGKQLLLSADSGAEA--------ALQAELAEIQEKWKSASMRLEEQKK 7595
Query: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQA 3555
+D + +A+ +KL + FK+ + H L+ E + R K ++ A
Sbjct: 7596 KLAFLLKDWEKCEKGIADSLEKL-----RTFKKKLSQSLPDHHEELHAEQM-RCKELENA 7649
Query: 3556 IKNGQ------ALLKQT-----TGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ 3604
+ + +LLK T + +++ ++ E+++ ++ ++ ++ S + + +
Sbjct: 7650 VGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLN 7709
Query: 3605 LATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV 3664
F +EL WL ++E +++ +G E I + ++ +E E+++ L +
Sbjct: 7710 EWAVFSEKNKELCEWLTQMESKVSQNG-DILIEEMIEKLKKDYQEEIAIAQENKIQLQQM 7768
Query: 3665 NE-VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 3723
E +++A E +A E ++ + N++++ + D I RV ++ + QQ ++
Sbjct: 7769 GERLAKASHES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMS 7824
Query: 3724 AELAWVAETKRKLMALGPIRLEQ---DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 3780
+ W+A + +L PI + ++ +L Q+ DI +H + + + +
Sbjct: 7825 SLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVL 7882
Query: 3781 FGTCG----EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 3836
C + + +Q+ T +L +++ I ++ ER ++E L +F + Y
Sbjct: 7883 LHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFED 7942
Query: 3837 WIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 3896
W++ + A S + + +++ ++ + + E ++ + K +L N +
Sbjct: 7943 WLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 8002
Query: 3897 G-----EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLEN 3951
+MV E Q+ +N+ ++ +R+ L + Q + D I L ++
Sbjct: 8003 SACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARDSILVWLTEMD- 8057
Query: 3952 LSSRLRMPPLIPAEVDKIREC-----ISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4006
L ++ EC I K+ E+ E + +GE+LI +S+
Sbjct: 8058 ---------LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEP 8108
Query: 4007 ADKDLAAKEIQDKLDQMVFFWEDIKARAE-------------------EREIKFLDVLEL 4047
D A I+++LD++ + +++ R E +RE++ D L
Sbjct: 8109 LD----AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL 8164
Query: 4048 AEKFWYDMAA-LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETD---GLHEEL 4103
++ W+D +A L + + + ++ L P + + ++I E D L +L
Sbjct: 8165 SDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDL 8224
Query: 4104 EFIRILGADLIFACGETEKPEVRKS--------IDEMNNAW----ENLNKTWKERLEKLE 4151
E G+ +K + I E A+ EN K LE
Sbjct: 8225 ESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALE 8284
Query: 4152 DAMQAAVQYQDTLQAMFDWLDNTV-IKLCTMPPVGTDLNTVKDQLNEMKEF--KVEVYQQ 4208
++ + D + +N + K T P + T L E V+ +
Sbjct: 8285 SQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEH 8344
Query: 4209 QIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALG 4268
+++ E+ + G + L +T I R WE L + ++ +++ L
Sbjct: 8345 KLKEEEESLPGFVNLHSTETQTAGVIDR---------WELLQAQALSKELRMKQNLQKWQ 8395
Query: 4269 QFQHALEELMSWLTHTEELLDAQR--PISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326
QF L + +WL TEE L+ + +S D + IE+++ K L+ V +A + ++N
Sbjct: 8396 QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSIN 8455
Query: 4327 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4386
E ++ + ++ L+ RL MN W+ V EE LQ L Q QGFH
Sbjct: 8456 LCSPEFTQADS-KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGL 8514
Query: 4387 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4446
LL L ++ + + P E L H + Q+K ++LL+ + +D
Sbjct: 8515 LLMLENIDRRKNEIVPIDS--NLDAEILQDHHKQLMQIK------HELLESQLRVASLQD 8566
Query: 4447 DSGSGSKTEQSVALLE--QKWHVVSSKME---ERKSKLEEALNLATEFQNSLQEFINWLT 4501
S + LE +K HV+ ++++ + S+ + L + +S Q+ +W +
Sbjct: 8567 MSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSS 8626
Query: 4502 LAE 4504
E
Sbjct: 8627 ADE 8629
Score = 274 bits (700), Expect = 2e-72
Identities = 766/4278 (17%), Positives = 1655/4278 (38%), Gaps = 582/4278 (13%)
Query: 974 NLEKLRSSAPGECH-----QIMKNLQAHYEDFLQDSRDS--VLFSVADRL--RLEEEVEA 1024
NL+ + G+C ++ +N+ AH LQ ++DS + S A R+ LE E++
Sbjct: 3911 NLQMKGDTLIGQCADHLQAKLKQNVHAH----LQGTKDSYSAICSTAQRMYQSLEHELQK 3966
Query: 1025 ----------CKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSL 1074
C+A + +E + I ++K+ R L+E + + + S+
Sbjct: 3967 HVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRA-LQEQARTYLDLLCSM 4025
Query: 1075 -----ASSRTDRDAWQDNALRIAE-----QEHTQ--EDLQQLRSDLDAVSMKCDSFLHQS 1122
AS +T Q I + Q TQ E+++ L+S+L D L
Sbjct: 4026 CDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM 4085
Query: 1123 PSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQ 1182
S L N++ + D V L + K +V+ I+ + ++ +
Sbjct: 4086 KRRHSELELNIAQNMVSQVKDFVKKLQS----KQASVNTIIEKVN---------KLTKKE 4132
Query: 1183 EEVVLADLSALEAHWSTL-----------RHWLSDVKDKNSVFSVLDEEIAKAKVVAEQM 1231
E +++ L W L L +D + +V++ + K + +
Sbjct: 4133 ESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNL 4192
Query: 1232 SRLTPERN-LDLERYQEKGSQLQERWHRVIAQLEIRQSELESI----QEVLGDYRACHGT 1286
+R E + LE ++ LQER + + + +Q +E + +E++ + +
Sbjct: 4193 ARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQ 4252
Query: 1287 LIKWIEETTAQQEMMKPGQAEDSRV-------LSEQLSQQTALFAEIERNQTKLDQCQKF 1339
+E+ ++ + E+ V L E +Q AE + D Q
Sbjct: 4253 RWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNL 4312
Query: 1340 SQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLT 1399
+ I + E + M K+ ++ + L+ I + D ++ L L
Sbjct: 4313 LMDHLAICSELEAKQMLLKSLIKDADRVMADLG--LNERQVIQKALSDAQSHVNCLSDLV 4370
Query: 1400 TQHVKYISDALRRLEEEEKVVEE---EKQEHVEKVKELLGWVSTLARNTQGKATSSETKE 1456
Q KY++ AL + V + + Q+H K+ + R +K+
Sbjct: 4371 GQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQ 4421
Query: 1457 STDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNK 1516
+ A + E+T Q E +K +++E+EK ++ +L L
Sbjct: 4422 VKTCKSAQASLKTYQNEVTGLWAQGRELMK-----------EVTEQEKSEVLGKLQELQS 4470
Query: 1517 AYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERAL------ 1570
Y + +++LQ+L+ L + K + + C W+ QA+
Sbjct: 4471 VYDSVLQKCSHRLQELEKNLVSRKHFK----------EDFDKACHWLKQADIVTFPEINL 4520
Query: 1571 --AGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRE 1628
+ T + + + ++L +Q + + +++ + PR+
Sbjct: 4521 MNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQ 4580
Query: 1629 LTAL----REKLHQ------AKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKEL 1678
+ ++K ++ A+++Y +L E T + ELE + T+ A +E
Sbjct: 4581 FNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDL--AVEEA 4638
Query: 1679 AENKKKIDALLDWVTSVGSSGGQLLTNLPGME-------------------QLSGASLEK 1719
+ A+LD V +G + +L G +L + ++
Sbjct: 4639 LSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQR 4698
Query: 1720 GAL--DTTDGYMGVNQAPEKLDKQCEMMKAR----HQELLSQQQNFILATQSAQAFLDQ- 1772
+L DTT Y + ++L++Q + +K ++E L ++ + A + D
Sbjct: 4699 VSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSG 4758
Query: 1773 --------HGHNLTP--------EEQQMLQQKLGELKEQYST---SLAQSEAELKQVQTL 1813
H +L P + + +Q GELK S ++ + E+ + Q
Sbjct: 4759 IVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDF 4818
Query: 1814 QDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDV-------- 1865
Q E+ + L WL R + EL + + + +++ E+V
Sbjct: 4819 QTEMSRSLD-------WLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMN 4871
Query: 1866 -ISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLG 1924
+SHK +F D+E+S E SE+ +++ L+ T ++S+C R
Sbjct: 4872 ALSHKEKEKFTKAKELISADLEHSLAE---LSELDGDIQEALRTRQATLTEIYSQCQRY- 4927
Query: 1925 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 1984
Y FQ + D L+ + + L ++ + E +T Q L
Sbjct: 4928 ---------YQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNL 4978
Query: 1985 AEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI 2044
E V L + + + + +++ S+ Q +S + LLQ+
Sbjct: 4979 EELHSLVATLDPLIKPTGKED---------LEQKVASLELRSQRMSRDSGAQVDLLQRCT 5029
Query: 2045 AQSQSVQESLESLLQSIGEVEQNL-EGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLE 2103
AQ Q++ E +++ + + E+ L E + + SS +E L+ + L + +
Sbjct: 5030 AQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIV 5089
Query: 2104 ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLS 2163
A E ++ +T + + A L + V QR+ +L Q++E L+ + + F +
Sbjct: 5090 ALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKV 5149
Query: 2164 GKLQQFMENKSRMLASGNQPDQ---DITHFFQQIQELNLEMEDQQENLDTLEHLVTELSS 2220
K + ++ L + ++ + LE+E QQ L L +
Sbjct: 5150 KKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ 5209
Query: 2221 CGFA----------LDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVR 2270
G A ++ QDR N+++ K VK+ KD + Q++ +
Sbjct: 5210 DGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKC--- 5266
Query: 2271 TFQKWLKETEGSIP-PTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENL 2329
W++ET+ + PT E++ Q+E L+ LL + T+
Sbjct: 5267 ----WVQETKEYLGNPTI------EIDAQLEELQILLTE--------------ATNHRQN 5302
Query: 2330 IMEITAPDSQGKTG--SILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLH 2387
I ++ + G +ILPS S L E+ D+ + +K+ V
Sbjct: 5303 IEKMAEEQKEKYLGLYTILPSELSL-----------QLAEVALDLKIRDQIQDKIKEVEQ 5351
Query: 2388 ERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFL 2447
+ S Q + +++++ K+ ++L L++K T+ V K
Sbjct: 5352 SKATS-QELSRQIQKLAKDLTTILTKLKAK---------------TDNVVQAKTDQKVLG 5395
Query: 2448 AELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEE 2507
EL+ + K+ ++ A+ L N Q + K +L ++ R +L +
Sbjct: 5396 EELDGCNSKLMELDAAVQKFLEQ--NGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQ 5453
Query: 2508 SASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQV---QFMLKEFEARR 2564
+ASHL + + W+ + + VL +I N + ++Q Q +L+E +
Sbjct: 5454 AASHLEEYNEMLELILKWIEKAK----VLAHGTIAWNSASQLREQYILHQTLLEESKEID 5509
Query: 2565 QQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKST 2624
+ E + E Q + + T ++ +++ + ++ EL + R + A
Sbjct: 5510 SELEAMTEKLQYLTS-----VYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMK 5564
Query: 2625 QYQELLQDLSEKVRAVGQRLSVQSAISTQPE----AVKQQLEETSEIRSDLEQLDHEVKE 2680
+++ L+ L L A T PE ++K+QL + S++E L +V+
Sbjct: 5565 KFEAELKKLQAA-------LEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5617
Query: 2681 AQTLCDELSVLIGEQYLKDELKKRLETVALPLQG----LEDLAADRINRLQAALASTQQF 2736
Q LC ++ I E + L AL LQ L+ A + N +QAA+ +Q+
Sbjct: 5618 VQ-LCQS-ALRIPEDVVAS---LPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQY 5672
Query: 2737 QQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEE-------FQKSLNQHSGSYE 2789
+Q L+ ++ + ++ ++ LQ+Q+ +EE +Q+ + + +
Sbjct: 5673 EQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCK 5732
Query: 2790 VIV--AEGESLLLSVPP----GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA 2843
++ A+ ++LL+V E L +L+ + + TA R L
Sbjct: 5733 MLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTL------- 5785
Query: 2844 QKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QLESSLLRSKAMLNE---VEKRRSLLEI 2899
L P E+ + + ++ P + S + + A +N+ + S +
Sbjct: 5786 ---------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERL 5836
Query: 2900 LNSAADILINSS---EADEDGIRDEKAG----INQNMDAVTEELQAKTGSLEEMTQRLRE 2952
AA I ++S E E G+ + ++ + + + K +L E +R ++
Sbjct: 5837 QTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQK 5896
Query: 2953 FQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLR-NFT 3011
+Q+S ++I K+E +L++ ++ + + +A + + L+ +++ L+ +
Sbjct: 5897 YQDSLQSISTKMEAI--ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLA 5954
Query: 3012 QGLVEDAPDGSDASQLLHQA--EVAQQEFLEVKQRVNSGCVMMENKL----------EGI 3059
+ LV ++ + A QL Q+ V + ++ + + ++E KL + +
Sbjct: 5955 EELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQAL 6014
Query: 3060 GQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA 3119
++ C E+ S L LD + ++ +++Q+ D + L ++IE
Sbjct: 6015 QRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNML-------VEIEQKVV 6067
Query: 3120 ECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLN 3179
+ L L G + + GKL R K +L+ L K LN
Sbjct: 6068 ALSELSVHNENLLLEGKAHTKDEAEQLAGKL-RRLKGSLLELQRALHD--------KQLN 6118
Query: 3180 DATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAG 3239
TA E+ E+ + T+ + + LA + +Q Q LQQ
Sbjct: 6119 MQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQ---RQSSLQQ------------- 6162
Query: 3240 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQL------QEALLHCGKFQDALEPLLSWL 3293
+ ++E+ A +L + VA R ++ E G+ D L L
Sbjct: 6163 --------QKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELG-- 6212
Query: 3294 ADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAEL--- 3350
+ E+ A + + + +QKLLQ +L+ + V L + R+ L
Sbjct: 6213 MEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV--LYSRPNRLLSGVPLYKG 6270
Query: 3351 ----ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE 3406
D+ +T L+ L + E+ S++ ++Q + L ++ ++ S +L E
Sbjct: 6271 DVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVE 6327
Query: 3407 KKLANSE---PVGTQTAKIQQQIIRH--KALEEDIENHATDVHQAVKIGQSLSSLTSPAE 3461
++L + P T+T Q+I+ K + E+++ + QA +
Sbjct: 6328 ERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFP--------ENGDN 6379
Query: 3462 QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAE----VEDK 3517
+ V+ + + L R S + ++ + + L F D + LA+ + K
Sbjct: 6380 RDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6439
Query: 3518 LSSVFVKDFKQDVLHRQHADH--LALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQ 3575
L++VF + + + Q A+ + I+ K+ D + ++Q + +E+ +Q
Sbjct: 6440 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGD------KLQVEQPSMQELSKLQ 6493
Query: 3576 EKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQS- 3634
+ Y ++ + L Q L ++++ ++L L +E++A G Q
Sbjct: 6494 D-------MYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMA--GDQKI 6544
Query: 3635 --PTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANE 3692
+ E+I Q + KE + + H ++ +T + R ++ + + +L++ A+
Sbjct: 6545 IVSSKEEIQQLLDKHKEYFQGLESHMILTET---LFRKIISFAVQKETQFHTELMAQASA 6601
Query: 3693 QYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ 3752
K +R E++ ++ ++ + + + ++G + +D+ +
Sbjct: 6602 VLKRAH----KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDR 6657
Query: 3753 LQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQ---EKTESLIQQYEAISLL 3809
+ + + K S++E ++ +++ + ++ ++ ES + Q L
Sbjct: 6658 ITLYQHL-------KSSLNE---YQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLS 6707
Query: 3810 NSERYAR-LERAQVLVNQFWETYE----ELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 3864
N+ + ++ L R + ++ + W Y+ +L W++ + + ++ + Q+ E
Sbjct: 6708 NTNKMSKELHRLETIL-KHWTRYQSESADLIHWLQSAKDRLEFWTQQSV---TVPQELEM 6763
Query: 3865 MRQLRESIAEHKPHID-------KLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEE 3917
+R + E +D +L G QL L + + + + ++ + +
Sbjct: 6764 VRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTN 6823
Query: 3918 VRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNK 3977
+ A+ E + Q DK+ E +S M +I + D I+ I K
Sbjct: 6824 IP----AVQEKLHQLQM-----DKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG-YK 6873
Query: 3978 SATVELEKLQPSFEA---LKRRGEELIGRS--QGADKDLAAK-----EIQDKLDQMVFFW 4027
+ L+K + F+ K+ + + +S Q + +D+ +K + ++L M W
Sbjct: 6874 AIHEYLQKYK-GFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSW 6932
Query: 4028 EDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVE 4087
+ ++ E+ +LE ++ ++ L T + + + G D + ++ ++
Sbjct: 6933 QILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALK 6991
Query: 4088 AAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERL 4147
+ +++ +E+E I G LI E V ++ E+ W NL+ +
Sbjct: 6992 DCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLD----HMV 7047
Query: 4148 EKLEDAMQAAVQYQDTLQAMFDWLDNTVIK----LCTMPPVGTDLNTVKDQLNEMKEFKV 4203
+L+ +++ + + + FD +++ +++ L + L V+ Q++ ++ +
Sbjct: 7048 GQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQD 7107
Query: 4204 EVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGA 4263
++ +Q+ ++K +LK+ + + L E+ W NL E+IA + +
Sbjct: 7108 DLEKQERSLQKFGSITNQLLKECHPPV-TETLTNTLKEVNMRWNNLLEEIAEQLQSSKAL 7166
Query: 4264 LLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVE 4323
L +++ ++ S + E+ + + + + + E+A ND+L TV+
Sbjct: 7167 LQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVK 7226
Query: 4324 T----VNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGF 4379
+++ G +L + AS+++S +++Q ++ Q +++ LQ+ + + F
Sbjct: 7227 DSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETF 7286
Query: 4380 HSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLL-DKG 4438
+E + E L P+ L T E +LK + ++ + D
Sbjct: 7287 AKSLEALEAWIVEAEEILQGQDPSHS------SDLSTIQERMEELKGQMLKFSSMAPDLD 7340
Query: 4439 RLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFIN 4498
RL L K + + L + W ++SS+ ER SKL+ L F + ++
Sbjct: 7341 RLNELGY-RLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWME 7399
Query: 4499 WLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQ 4558
+L EQ L + + +L Q H++F E+ + + + + G +L Q
Sbjct: 7400 FLVQTEQKLAVEISGN--YQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVD 7457
Query: 4559 DVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDS 4618
D L + ++W+ V++R+ +R +D ++ +++ E +KL WL + S
Sbjct: 7458 DRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMS 7517
Query: 4619 ELEISNDPDKIKLQLSKHKEF-QKTLGGKQPVYDTTIRTGRALKEKTLLPEDS---QKLD 4674
L P + L +F +K +Q Y T+ G+ L LL DS L
Sbjct: 7518 GLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQL----LLSADSGAEAALQ 7573
Query: 4675 NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHG 4734
L E+++KW + + E++ KL L + + ++ L + +L++ P H
Sbjct: 7574 AELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHH 7633
Query: 4735 DLDLVMNLMDAHKVFQKELGKRTGT-------VQVLKRSGRELIENSRDDTTWVKGQLQE 4787
+ + A ++ KEL G+ + +LK + I S DD + + +++
Sbjct: 7634 E------ELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYI--SADDISILNERVEL 7685
Query: 4788 LSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEAL 4847
L +W+ +C ++ ++ + L + VF + L EWL++ E + G + + E +
Sbjct: 7686 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIE-EMI 7744
Query: 4848 QSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTW 4907
+ L ++E + +E ++ + MGE + H + I++ + + R++ +L
Sbjct: 7745 EKLKKDYQEEIAIAQENKIQLQQ---MGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 7801
Query: 4908 AKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQ---NIDRVKALIAE 4964
++L+ L + + + L W+ E+ L +PI N + ++ + E
Sbjct: 7802 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL----AKPIVYDSCNSEEIQRKLNE 7857
Query: 4965 HQTFMEEMTRKQPDVDRV 4982
Q ++ + V V
Sbjct: 7858 QQELQRDIEKHSTGVASV 7875
Score = 273 bits (698), Expect = 3e-72
Identities = 834/4518 (18%), Positives = 1723/4518 (38%), Gaps = 713/4518 (15%)
Query: 975 LEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMK 1034
+EK+ S+ G+C Q + ++ E+ + S++ V L E EA + H K
Sbjct: 1231 VEKMLSNF-GDCVQYKEIVKNSLEELISGSKE-VQEQAEKILDTENLFEAQQLLLHHQQK 1288
Query: 1035 ----SMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALR 1090
S + D ++ +A+ E + R E +++ + L SR ++ LR
Sbjct: 1289 TKRISAKKRDVQQQIAQAQQGE-GGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLR 1347
Query: 1091 IAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLST 1150
E+ T ++ + L + FL S SS+ +L SEL E ++
Sbjct: 1348 KWERFETNKET--VVRYLFQTGSSHERFL----SFSSLESLSSELEQTKEFSKRTESIAV 1401
Query: 1151 VYLNKLKTVDVIVRSIQDAELL----------VKGYEIKLSQE----EVVLADLSALEAH 1196
N +K I Q+ +LL VK E L ++ E+V ++
Sbjct: 1402 QAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSN 1461
Query: 1197 WSTLRHWLSDV-KDKNSV---FSVLDEEIAKAKVVAEQM-SRLTPERNLDLERYQEKGSQ 1251
+ TL W+++ K+ N++ S +D +I++ KV +++ S+L+ L+ +E S
Sbjct: 1462 FETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLE----EEAQSF 1517
Query: 1252 LQERWHRVIAQLEIRQSELESIQEVLGDYRAC-HGTLIKWIEETTAQQEMMKPGQAEDSR 1310
Q A+++ + +++ E L ++ C GT++ + +QQ+ + E+ R
Sbjct: 1518 AQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHL----SQQQKFE----ENLR 1569
Query: 1311 VLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGK 1370
+ + +S+ A + + + K Q++ + + E AF S +K
Sbjct: 1570 KIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARK---- 1625
Query: 1371 RRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEK 1430
+ + D+ QE L+ +Y D LRR +E + +E
Sbjct: 1626 ----VVNRDSCVQEAAALQQQY--------------EDILRRAKERQTALENLLAHWQRL 1667
Query: 1431 VKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI 1490
KEL +++ L R + KA+S E S D K E Q++ + E VS+A S++
Sbjct: 1668 EKELSSFLTWLERG-EAKASSPEMDISADRVKVEGELQLIQ---ALQNEVVSQASFYSKL 1723
Query: 1491 FLAKHG--HKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA-HQTEQKTLQK 1547
K S+ + K + L L++ + DL ++ LQS +A HQ + L
Sbjct: 1724 LQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLS 1783
Query: 1548 QQNTCHQQLEDLCSWVGQAERALAGHQ-GRTTQQDLSA-LQKNQSDLKDLQDDI------ 1599
L +L + +E ++ HQ T +D +A ++ + +L+ LQ +
Sbjct: 1784 FSVWIKLFLSELQT---TSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSL 1840
Query: 1600 ---------QNRATSFATVVKDIEGFMEENQTKLSP-----RELTALREKLHQAKEQYEA 1645
Q +A + ++ +E Q LS + +L L Q ++ EA
Sbjct: 1841 GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEA 1900
Query: 1646 LQEETRVAQKELEEAVTSALQQETEKSKAAKEL------AENKKKIDALLDWVTSVGSSG 1699
+ +E+ + ALQ AA L A+ KI + + TS ++
Sbjct: 1901 TNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSS-EQRTSCRATA 1959
Query: 1700 GQLLTNLPGMEQLSG---------ASLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARH 1749
QL + ++ L G A L+K D + + + E+ DK E +K
Sbjct: 1960 DQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK--ERLKEPT 2017
Query: 1750 QELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ 1809
++ L Q+ + + L+ H H L L+ K ++ ++ + + E+ +
Sbjct: 2018 RQALQQR---LRVFNQLEDELNSHEHELC-----WLKDKAKQIAQKDVAFAPEVDREINR 2069
Query: 1810 VQTLQDELQKFLQDH-----------KEFESWLERSEKELENMHKGGSSPETLPSLLKRQ 1858
++ D+ ++ + ++ +E+++ K LEN + T+ +
Sbjct: 2070 LEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLK 2129
Query: 1859 GSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE--------PSEIGNLVKDKLKDAT 1910
+FS+ + K + + K D++N +GK S +LVK ++
Sbjct: 2130 WAFSKHETA-KNKMNY------KQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTV 2182
Query: 1911 ERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLS--DTVASDPG 1968
+++ + K L + L + ++ D ++ W C + + +S D
Sbjct: 2183 DKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEE 2242
Query: 1969 VLQEQLATTKQLQEELAEHQVPVEKLQKVAR------DIMEIEGEPAPDHRHVQETTD-- 2020
+L+E + K L E V L+++ + D+ IE + H +E T+
Sbjct: 2243 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVA 2302
Query: 2021 -SILSHFQSLSYSLAE------------RSSLLQ-------KAIAQSQSVQESLESLLQS 2060
L F + S + + SL+ +A+ + + +Q+ L+S +
Sbjct: 2303 KGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSN 2362
Query: 2061 IGEVEQNL----------EGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLE-----AT 2105
I ++NL E + + +G+I++ A + + A + SLE +
Sbjct: 2363 ISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESM 2422
Query: 2106 REMVTRFM-------ETADST-TAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAE 2157
+E F+ E++D T + VL+ KL ++ + + + +S L + + +
Sbjct: 2423 QEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSV----SDGQSKLDAVTQEGQ 2478
Query: 2158 -MFEHLSGKLQQFMENKSRMLASGNQPDQ------------------DITHFFQQIQELN 2198
++ HLS +Q + + + N+ Q ++ F Q ++LN
Sbjct: 2479 TLYAHLS---KQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLN 2535
Query: 2199 LEMEDQQENLDT-------------------LEHLVTELSSCGFALDLCQHQDRVQN--- 2236
L + + +E +T +E + EL + +LD + ++ +
Sbjct: 2536 LWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEG 2595
Query: 2237 ---------LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQK---WLKETEGSIP 2284
+ T Q ++ ++ SCQ L E L Q W+K + +
Sbjct: 2596 HGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLA 2655
Query: 2285 PTETSMSAKE-LEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG 2343
E+++ +K+ LEK++ ++ +L KG L M I GK
Sbjct: 2656 CAESTLGSKDTLEKRLSQIQDIL-------------LMKGEGEVKLNMAI------GKGE 2696
Query: 2344 SILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEV 2403
L S + G + L E+ D+ ++ Q +L++++++ +
Sbjct: 2697 QALRS-SNKEGQRVIQTQLETLKEVWADIMSSSV----------HAQSTLESVISQWNDY 2745
Query: 2404 HKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA 2463
+ N + QW+ES ++ ++ K + V + ++ L+E E ++ + ++
Sbjct: 2746 VERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLL--DHLQSILSEAEDHTRALHRL--- 2800
Query: 2464 LAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLR 2523
+A Y +++ QEEL +++ V + R++EE + A +
Sbjct: 2801 IAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFT 2860
Query: 2524 PWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTG 2580
WL + + +S D + + +++ ++ E +R + E L + T
Sbjct: 2861 DWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTA 2920
Query: 2581 PGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKST-----------QYQEL 2629
G + T E+Q++ W + D + S ++ + + Q ++
Sbjct: 2921 SGCELMHT-----EMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQA 2975
Query: 2630 LQDLSEKVRAVGQRLSVQSAISTQPEAVK------------QQLE-ETSEIRSDLEQLDH 2676
L+ S ++ Q+L++ +T E V+ Q+ E T +++S L +L
Sbjct: 2976 LEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCR 3035
Query: 2677 EVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQF 2736
++ T ++S LI E L LQ + N+ Q Q+F
Sbjct: 3036 FSRDLSTYSGKVSGLIKEYN------------CLCLQASKGCQ----NKEQIL---QQRF 3076
Query: 2737 QQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGE 2796
++ F + + WL + + AK I + + + LQ+ +EF +++++GE
Sbjct: 3077 RKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGE 3136
Query: 2797 SLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPW 2856
LL ++ E+ + +Q ++ K W+ ++S L++ + + ++ E + W
Sbjct: 3137 -LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDW 3195
Query: 2857 IEDCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADE 2915
+ + + E L D + +++L E+ L L A L A +
Sbjct: 3196 LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASK 3255
Query: 2916 DGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF- 2974
R + ++ A++ + K L+ + +F K ++ + A H L+ +
Sbjct: 3256 S-FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3314
Query: 2975 DALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVED-APDGSDASQLLHQAEV 3033
++ + KL A V Q E Q+ + + ++++ +P+G
Sbjct: 3315 HPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEG---------IPT 3365
Query: 3034 AQQEFLEVKQR---VNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT 3090
QQ+ VK + S + +++LEG ++ Q + +D M A ++
Sbjct: 3366 IQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGW---MDSMEANLNES 3422
Query: 3091 DSLQSQIEDVRLFLNKIHVLKLDI-------EASEAECRHMLEEEGT-LDLLGLKRELEA 3142
+ +++ D L K +L ++ E E + M E T L+L L+ A
Sbjct: 3423 ERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRA 3482
Query: 3143 LNKQCG-------KLTERGKARQEQL---ELTLGRVE---DFYRKLKGLNDATT------ 3183
+ ++ KL + Q L E+ LG+ + D Y L+G DA T
Sbjct: 3483 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEG--DAHTHETTLR 3540
Query: 3184 --------AAEEAEALQWVVGTEVEIINQQLA------------DFKMFQ---------- 3213
AE L V+ T ++I + D++ +Q
Sbjct: 3541 DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3600
Query: 3214 KEQVDPLQMKLQQVNGLGQGLIQSAGKDC--DVQGLEHDMEEINAR-------------- 3257
V+ L++ Q+ + + L + K +V ++EE+ AR
Sbjct: 3601 NNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRM 3660
Query: 3258 ----------WNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPS 3307
+ L +V ++I L+E + + + +L W T + N K +
Sbjct: 3661 GCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHK---NFKNVA 3717
Query: 3308 AEYKVVKAQIQEQKL--LQRLLDDRKATVDMLQA---EGGRIAQSAELADREKITGQLES 3362
+ V + +KL L+ LL D + +L++ +G R + E + E++ ++
Sbjct: 3718 TKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHD 3777
Query: 3363 LESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKI 3422
+ EL S LE L LAK+F + + ++ +++ ++ L E + +
Sbjct: 3778 HMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEK 3837
Query: 3423 QQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDR 3482
+ Q+ ++K+L++ + +H V + G++L L L +KID LQ+ Y QD
Sbjct: 3838 KAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV---TLKDKIDQLQSDY---QDL 3891
Query: 3483 CCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALN 3542
C A++++ +A ED+L+++ K D L Q ADHL
Sbjct: 3892 CSIGKAMMEE------------------IAGFEDRLNNL---QMKGDTLIGQCADHL--- 3927
Query: 3543 EEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQA 3602
QA LKQ + L G K Y+ I T+ + ++LE
Sbjct: 3928 -----------------QAKLKQN-------VHAHLQGTKDSYSAICSTAQRMYQSLEHE 3963
Query: 3603 RQLATKFQSTYEELTGWLREVEEELATSGGQSPTG-----EQIPQFQQRQKELKKEVMEH 3657
Q Q T ++ WL V+ +L S Q P +Q+ F+ Q++ + +
Sbjct: 3964 LQKHVSRQDTLQQCQAWLSAVQPDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDLL 4022
Query: 3658 RLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN-----EQYKLVSDTIGQRVDEIDAAI 3712
+ D N + + + + KLV N E+ K + + + + D +
Sbjct: 4023 CSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQL 4082
Query: 3713 QRSQQYEQAADAELA--WVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSM 3770
Q ++ + +A V++ K + +L+ Q + ++K +
Sbjct: 4083 QNMKRRHSELELNIAQNMVSQVKDFVK-----KLQSKQASVNTIIEKVNKLTKKEESPEH 4137
Query: 3771 DELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWET 3830
E+ + C + LQ + E L + + +N +V + +F
Sbjct: 4138 KEINHLNDQWLDLCRQSNNLCLQRE-EDLQRTRDYHDCMNV--------VEVFLEKFTTE 4188
Query: 3831 YEELSPWIEETRAL-IAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL 3889
++ L+ E+ A+ + L A+ ++ + E+++ ++ + EH
Sbjct: 4189 WDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEH-------------- 4234
Query: 3890 KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 3949
LN ++ E+V+E+ E + Q+++ ++++ + +V+ ++ + + ++E
Sbjct: 4235 --LNLDDKELVKEQTSHLEQRWFQLEDLIKRK---IQVSVTNLEELNVVQSRFQELMEWA 4289
Query: 3950 E----NLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4005
E N++ L+ P D + + D+ + ELE Q ++L + + ++
Sbjct: 4290 EEQQPNIAEALKQSP----PPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLG 4345
Query: 4006 GADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT--IK 4063
++ + K + D + + + R K+L+ L+EK + MA T I+
Sbjct: 4346 LNERQVIQKALSDAQSHVNCLSDLVGQRR-----KYLNKA-LSEKTQFLMAVFQATSQIQ 4399
Query: 4064 DTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKP 4123
+ + E + P + +QV+ ++ + E+ + G +L+ E EK
Sbjct: 4400 QHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKS 4459
Query: 4124 EVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4183
EV + E+ + ++++ + RL++LE + + +++ WL I T P
Sbjct: 4460 EVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI--VTFPE 4517
Query: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKL----NHQGELMLKKATDETDRDIIREPL 4239
+ +N + ++ +++ + +Q E E L G+ +L + +E D + E L
Sbjct: 4518 INL-MNESSELHTQLAKYQ-NILEQSPEYENLLLTLQRTGQTILP-SLNEVDHSYLSEKL 4574
Query: 4240 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4299
L + + + +K++ A+LA ++ +E LT T+ L +
Sbjct: 4575 NALPRQFNVIVALAKDKFYKVQEAILARKEYASLIE-----LT-TQSLSE---------- 4618
Query: 4300 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-----DDASSLRSRLEAMNQC 4354
+E + + + D+ +A ++ +L+ AG D+ + + + Q
Sbjct: 4619 -LEAQFLRMSKVPTDLAVEEAL--SLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQP 4675
Query: 4355 WE--------SVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGL 4406
W+ ++ + + + +Q S L+ + E E +L R QL + K
Sbjct: 4676 WQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLER---QLKSVKEEQSK 4732
Query: 4407 PETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML---LSRDDSGSGSKTEQSVALLEQ 4463
+ +++Y L + +L + + L D + K + +
Sbjct: 4733 VNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQG 4792
Query: 4464 KWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQ 4523
+ +++S + E ++ E + + +FQ + ++WL + L+ L L + +
Sbjct: 4793 ELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEE 4852
Query: 4524 IEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIE 4583
I + ++ EV + + L + KF K+ + ++ S + +Q ++
Sbjct: 4853 IRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELISADLEHSLAELSELDGDIQEALR 4911
Query: 4584 -RGRSLDDARKRAKQFHEAWKKLIDWLEDA----------------ESHLDSELEISNDP 4626
R +L + + +++++ ++ DWLEDA E +L S +E +
Sbjct: 4912 TRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTE 4971
Query: 4627 DKIKLQLSKHKEFQKTLG------GK----QPVYDTTIRTGRALKEK----------TLL 4666
D+ L + TL GK Q V +R+ R ++ T
Sbjct: 4972 DQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQ 5031
Query: 4667 PEDSQK----LDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKV 4722
D QK + + + K H+ EE L + + + + + +
Sbjct: 5032 WHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL 5091
Query: 4723 EPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVK 4782
E + ++ + D V+Q R ++ + + +++E++ D+ T
Sbjct: 5092 EEKASQLEKTGNDASKATLSRSMTTVWQ-----RWTRLRAVAQDQEKILEDAVDEWTGFN 5146
Query: 4783 GQLQELSTRWDTVC-KLSVSKQSRLEQA-LKQAEVFRDTVHMLLEWLSEA-----EQTLR 4835
++++ + D + KL S + +A L + DT + LE A +QTL
Sbjct: 5147 NKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLS 5206
Query: 4836 FR--GALPDDTEA--LQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIK 4891
GA P E L I ++ ++EK V N + E+ I ++K
Sbjct: 5207 MLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEK-VKTNGKLVKQELKDREMVETQINSVK 5265
Query: 4892 HWI----------TI-IRARFEEV---LTWAKQHQQRLETALSELVANAELLEELLAW-- 4935
W+ TI I A+ EE+ LT A H+Q +E E L +L
Sbjct: 5266 CWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSEL 5325
Query: 4936 -IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPT 4994
+Q AE L + ++ I I V+ A Q ++ + D+ + K K
Sbjct: 5326 SLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVV 5385
Query: 4995 HAPFIEK----SRSGGRKSLSQPTPPPMPILSQS----EAKNPRINQLSARWQQVWLLAL 5046
A +K G L + L Q+ + +I +L+ QQ A
Sbjct: 5386 QAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAE 5445
Query: 5047 ERQRKLNDALDRLEELKE 5064
R KLN A LEE E
Sbjct: 5446 NRLSKLNQAASHLEEYNE 5463
Score = 256 bits (655), Expect = 3e-67
Identities = 754/4224 (17%), Positives = 1580/4224 (37%), Gaps = 545/4224 (12%)
Query: 929 AIEMASRVEQSYQKVMALWHQLHVNTKSLIS--------WNYLRKDLDLVQTW--NLEKL 978
++E A V + + A W L V +S+ S W+ + +Q W + EK+
Sbjct: 583 SVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKM 642
Query: 979 RSSAPGECHQIMKNLQAHYEDFL-QDSRDSVLFSVADRL---RLEEEVEACKARFQHLMK 1034
+ + +NL + + + L D + L++++ R++ L
Sbjct: 643 LNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFM 702
Query: 1035 S---------MENEDKEETVAKMYISEL-----KNIRLRLEEYEQRVVKRIQSLASSRTD 1080
M+ KE T + +S K + LE V IQ L
Sbjct: 703 EVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQR 762
Query: 1081 RDAWQDNALRIAEQEH--TQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLL 1138
I + H T+E Q+ ++ A K L + S P L LL
Sbjct: 763 VPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS-PLLYESQQLL 821
Query: 1139 VEKMDHVYGLSTVY--LNKL-KTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEA 1195
+ + +++ Y L K+ + + V+ R Q + L + ++ L+ +E L+ +E
Sbjct: 822 IPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEK 881
Query: 1196 HWSTLRHW--LSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQ 1253
+++ + LS+V K+ + L +IA V + M + T D +++ E S+L
Sbjct: 882 GSQSVQKFVTLSNVL-KHFDQTRLQRQIADIHVAFQSMVKKTG----DWKKHVETNSRLM 936
Query: 1254 ERWHRVIAQLE----IRQSELESI---QEVLG---------DYRACHGTLIKWIEETTAQ 1297
+++ A+LE I Q LE +E+L D R + L E T
Sbjct: 937 KKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDIL 996
Query: 1298 QEMMKPGQAEDSRVLSEQLS-----------------QQTALFAEIERNQTKLDQCQKFS 1340
E + G E R L +Q ++ A +E +T+LD+ K
Sbjct: 997 PEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLM 1056
Query: 1341 QQYST--IVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMD--LRTRYTALV 1396
Q + I+K++ + F + ++R L + D T T V
Sbjct: 1057 PQEGSEKIIKEHRV------FFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHV 1110
Query: 1397 TLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQG-KATSSETK 1455
TL S + +E+ +K +++ + E W+ST +G K + +T
Sbjct: 1111 TLKELRAAIDSTYRKLMEDPDKW-----KDYTSRFSEFSSWISTNETQLKGIKGEAIDTA 1165
Query: 1456 ESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALN 1515
++++A+ E + TK+ + +K+ L + SE E ++ ++L L+
Sbjct: 1166 NHGEVKRAVEEIR----NGVTKRGETLSWLKSRLKVLTEVS---SENEAQKQGDELAKLS 1218
Query: 1516 KAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQG 1575
++ L ++++++ S + K + K N+ + + QAE+ L
Sbjct: 1219 SSFKALVT-LLSEVEKMLSNFGDCVQYKEIVK--NSLEELISGSKEVQEQAEKILDTENL 1275
Query: 1576 RTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREK 1635
QQ L Q+ + + D+Q + A + G + +L R+L + +
Sbjct: 1276 FEAQQLLLHHQQKTKRISAKKRDVQQQ---IAQAQQGEGGLPDRGHEEL--RKLESTLDG 1330
Query: 1636 LHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSV 1695
L +++E+ E + ++ + + ET K + L +
Sbjct: 1331 LERSRERQE----------RRIQVTLRKWERFETNKETVVRYLFQT-------------- 1366
Query: 1696 GSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQ 1755
GSS + L+ +E LS +L++ E K R + + Q
Sbjct: 1367 GSSHERFLS-FSSLESLSS----------------------ELEQTKEFSK-RTESIAVQ 1402
Query: 1756 QQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQD 1815
+N + L P+ +Q+LQQ+ +KEQ E ++K ++ ++
Sbjct: 1403 AENLVKEASEIP---------LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKT 1453
Query: 1816 ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFV 1875
+ F + + W+ EKEL + S+ + S +K V + + +
Sbjct: 1454 KWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK--------VTIQEIESKLS 1505
Query: 1876 TISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTAL--HSKCTRLGSHLNMLLGQ 1933
+I G + + SF + E +K KL L H++C +LG
Sbjct: 1506 SIVGLE--EEAQSFAQFVTTGESAR-IKAKLTQIRRYGEELREHAQCLE-----GTILGH 1557
Query: 1934 YHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEK 1993
Q Q ++L+ Q+ D +A + T K LQE + Q +E
Sbjct: 1558 LSQQQKFEENLRKIQQSVSE-----FEDKLAVPIKICSSATETYKVLQEHMDLCQA-LES 1611
Query: 1994 LQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES 2053
L + VQE ++ ++ + ER + L+ +A Q +++
Sbjct: 1612 LSSAITAFSASARKVVNRDSCVQEAA-ALQQQYEDILRRAKERQTALENLLAHWQRLEKE 1670
Query: 2054 LESLLQSIGEVEQNLEGKQVSSLSSGV-IQEALATNMKLKQDIARQKSSLEATREMVTRF 2112
L S L + E ++ + V ++ L L+ ++ Q S ++
Sbjct: 1671 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1730
Query: 2113 METADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMEN 2172
A +++ L ++ +R+ L ++ + L+ ++ + + F+ L ++
Sbjct: 1731 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI-- 1788
Query: 2173 KSRMLASGNQPDQDITHFFQQI-----QELNLEMEDQQENLDTLEHLVTELSSCGFALDL 2227
++ S Q +I+ Q+ ++ E+E ++ L +L+ + +L S G A DL
Sbjct: 1789 --KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDL 1846
Query: 2228 CQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLK--ETEGSIPP 2285
Q + ++ + F E + V+ R+ S E L L ++ + E S+
Sbjct: 1847 HLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1906
Query: 2286 TETSMSAKELEKQIEHLKSL------LDDWASKGTLVEEINCKGTSLENLIMEITAPDSQ 2339
E+ + K+L +++ K+L LD SK +I G+S + TA
Sbjct: 1907 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKI---GSSEQRTSCRATADQLC 1963
Query: 2340 GKTGSILPSVGSSVGSVNGYHTCK-----DLTEIQCDMSDVNLKYEKLGGVLHERQESLQ 2394
G+ I +G+ + K E+ + D+ + +K + +++LQ
Sbjct: 1964 GEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQ 2022
Query: 2395 AILNRMEEVHKEANS---VLQWLESKEEVLKSMDAMSSP---TKTETVKAQAESNKAFLA 2448
L ++ E NS L WL+ K + + D +P + ++ + K +
Sbjct: 2023 QRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIH 2082
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEES 2508
E + L L+ Y N + A + K+ E +S T T+ Q L+
Sbjct: 2083 ENQGQCC-------GLIDLMREYQNLKSAVS--KVLENASS--VIVTRTTIKDQEDLK-- 2129
Query: 2509 ASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHE 2568
W K K ++ + K+ + + +
Sbjct: 2130 ----------------WAFSKH----------------ETAKNKMNYKQKDLDNFTSKGK 2157
Query: 2569 QLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE 2628
L + I + D SL V+ +++S KW+++++KL +D+ V + + +
Sbjct: 2158 HLLSELKKIHS--SDFSL----VKTDMESTVDKWLDVSEKL---EENMDRLRVSLSIWDD 2208
Query: 2629 LLQDLSE----KVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSD---LEQLDHEVKEA 2681
+L E V Q S + A + E SE+++ LE+L +V +
Sbjct: 2209 VLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDL 2268
Query: 2682 QTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFD 2741
+ L L Q+++ +L ++LE +++ L+ A + Q ++ +
Sbjct: 2269 KELTKNLETPPDLQFIEADLMQKLEHA-------KEITEVAKGTLKDFTAQSTQVEKFIN 2321
Query: 2742 ELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS 2801
++ TW K + NC + E L+ +E Q + S + E + + L
Sbjct: 2322 DITTWF-TKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENL-----NSLCR 2375
Query: 2802 VPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCK 2861
E +L + L E +S+ + Q+ L++ ++K + +++ W K
Sbjct: 2376 KYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFLGAK 2433
Query: 2862 AKMSELR-VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADIL-INSSEADEDGIR 2919
A E T D LE+ L + +L+ V +S L+ + L + S+ I+
Sbjct: 2434 AAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQ 2493
Query: 2920 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG- 2978
++ N+ A ++ +L++ L F++ + + + + + + LG
Sbjct: 2494 EQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT-ENLGE 2552
Query: 2979 -SQACSNKNLEKLRAQQ---EVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA 3034
Q K E + + E+L A E +D L Q L E+ +L Q +
Sbjct: 2553 SKQHIPEKKNEVHKVEMFLGELLAARE-SLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS 2611
Query: 3035 QQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQ 3094
Q L + + C + + E + + ++ M+ + + D L + D+L+
Sbjct: 2612 HQNLLRMTKEKLRSCQVALQEHEALEE---ALQSMWFWVKAIQDRLACAESTLGSKDTLE 2668
Query: 3095 ---SQIEDVRLFLNKIHV-LKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL 3150
SQI+D+ L + V L + I E R +E + ++ +LE L + +
Sbjct: 2669 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRV----IQTQLETLKEVWADI 2724
Query: 3151 TERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFK 3210
Q LE + + D+ + L QW+ + +I +
Sbjct: 2725 MSSSVHAQSTLESVISQWNDYVERKNQLE------------QWMESVDQKIEHPLQPQPG 2772
Query: 3211 MFQK-EQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHD-------MEEINARWNTLN 3262
+ +K +D LQ L + + L + K ++ D EE+ ++N +
Sbjct: 2773 LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIM 2832
Query: 3263 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3322
+++ +++E + + DA+ WL +E + S + + ++ +
Sbjct: 2833 TVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSK--- 2889
Query: 3323 LQRLLDDRK---ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379
++ L+D R+ + + +++ + Q+ + E + ++++L + W + Q
Sbjct: 2890 IKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQS 2949
Query: 3380 QLEDI---LVLAK--------QFHETAEPISDFLSVTEKKLANSEPVGTQTA------KI 3422
LE++ + L++ Q + E S L ++L E T K
Sbjct: 2950 CLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKG 3009
Query: 3423 QQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDR 3482
Q+ + + E E+ + +++ + + LS+ + G +S I +
Sbjct: 3010 QEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS-----GKVSGLIKEYNCLCLQASKG 3064
Query: 3483 CCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALN 3542
C K +L Q A + WL V K+++ D Q++ + + L
Sbjct: 3065 CQNKEQILQQRFRKAFR------DFQQWL--VNAKITTAKCFDIPQNI--SEVSTSLQKI 3114
Query: 3543 EEIVNRKKN----VDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRT 3598
+E ++ +N ++ + G+ L T E+ IQ K+ K + + +
Sbjct: 3115 QEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESA 3174
Query: 3599 LEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR 3658
LE + F+ + E + WL + E+ + S + + QQ+ + + +E+ +
Sbjct: 3175 LENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYE 3234
Query: 3659 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 3718
L+ + E ++ L E A + VS + QY +S+ ++V +D + Q+
Sbjct: 3235 PQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQF 3292
Query: 3719 EQAADAELAWVAETKRKLMA-LGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHR 3777
W+ + L + P + + L+++ S+ + K+ ++ R
Sbjct: 3293 SLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK--QEKEIQMKMIVTR 3350
Query: 3778 SE-IFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 3836
E + E +Q++ +S+ + ++ ++LE A + + + S
Sbjct: 3351 GESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG 3410
Query: 3837 WIEETRALIAQLPSPAIDHEQLRQQQE---EMRQLRESIAEHKPHIDKLLKIGPQLKELN 3893
W++ ++ A L H +LR + + + L E + + ++ + ++K
Sbjct: 3411 WMD---SMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETI-----EVKGAG 3462
Query: 3894 PEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE--- 3950
E + + + Q + Y I+E + EAV++S ++ H + + L+ E
Sbjct: 3463 MTEHYVTQLELQDLQERYRAIQERAK-------EAVTKSEKLVRLHQEYQRDLKAFEVWL 3515
Query: 3951 -NLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4009
+L ++ + + D + V + Q ++ E++I +
Sbjct: 3516 GQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3575
Query: 4010 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDV---LELAEKFWYDMAALLTTIKDTQ 4066
D A + ++ W+ + R E +F +V L L E+ + + L T ++
Sbjct: 3576 DRALESLRQD-------WQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE-- 3626
Query: 4067 DIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVR 4126
+ EE +E+E + +++ + +
Sbjct: 3627 -----------------------KKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ 3663
Query: 4127 KSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGT 4186
+ ++ + ++ L E+++ LE+ +Q+ + + +L + DW +T V T
Sbjct: 3664 AT--QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGST---HKNFKNVAT 3718
Query: 4187 DLNTVKDQLNEMKEFKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRDIIREPLTE 4241
++ V + K +EV + +E ++ +GE + K +E + + +R+ + +
Sbjct: 3719 KIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAV-KYLEEGEAERLRKEIHD 3777
Query: 4242 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVI 4301
+ L + LE L +F + L W+ +E+L +
Sbjct: 3778 HMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEK 3837
Query: 4302 EVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQK 4361
+ +L+K+ L+ VL+H+ +V++V + G LLE + V K
Sbjct: 3838 KAQLSKYKSLQQTVLSHEPSVKSVREKGEALLE-------------------LVQDVTLK 3878
Query: 4362 TEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY 4421
++ QLQS Q + + E+ E +L+ + G +T Q H+
Sbjct: 3879 --DKIDQLQSDYQDLCSIGKAMME---EIAGFEDRLNNLQMKG---DTLIGQCADHL--- 3927
Query: 4422 SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4481
Q K K+ + L G+K S + S + LE
Sbjct: 3928 -QAKLKQNVHAHL---------------QGTKDSYS---------AICSTAQRMYQSLEH 3962
Query: 4482 ALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQI 4541
L Q++LQ+ WL+ + L + P L + Q++ + + + D +
Sbjct: 3963 ELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLL 4022
Query: 4542 IELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 4601
+ N +K +Q + E+ +++ + + ++L + K
Sbjct: 4023 CSMCDLSN-----------ASVKTTAKDIQ-QTEQTIEQKLVQAQNLTQGWEEIKHLK-- 4068
Query: 4602 WKKLIDWLEDAESHLD------SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 4655
+L +L+DA+ L SELE++ + + S+ K+F K L KQ +T I
Sbjct: 4069 -SELWIYLQDADQQLQNMKRRHSELELNIAQNMV----SQVKDFVKKLQSKQASVNTIIE 4123
Query: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
L +K PE + + + D+W +C +S + EE L + + D + +
Sbjct: 4124 KVNKLTKKEESPEHKE-----INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4178
Query: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-S 4774
+L K + D D + ++A K L +R ++ LK +++IE+ +
Sbjct: 4179 EVFLEKFTTEW--DNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLN 4236
Query: 4775 RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTL 4834
DD VK Q L RW + L K L++ V + L+EW E + +
Sbjct: 4237 LDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNI 4296
Query: 4835 RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWI 4894
+ Q+L+ H ++E K++ + S + + ++A + I+ +
Sbjct: 4297 AEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKAL 4356
Query: 4895 TIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQ-----E 4949
+ ++ + Q ++ L ALSE + + + IQ E ++ R+ +
Sbjct: 4357 SDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPD 4416
Query: 4950 PIPQNIDRVKALIAEHQTFMEEMT 4973
+ + + K+ A +T+ E+T
Sbjct: 4417 DVSKQVKTCKSAQASLKTYQNEVT 4440
Score = 212 bits (539), Expect = 9e-54
Identities = 504/2757 (18%), Positives = 1054/2757 (38%), Gaps = 332/2757 (12%)
Query: 2411 LQWLESKEEVLKSMDAMSSPTKT--------ETVKAQAESNKAFLAE---LEQNSPKIQK 2459
+++LE K +L + S K+ E+V+ ++ +F+ EQ Q
Sbjct: 510 MEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQI 569
Query: 2460 VKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAE 2519
+K+ + + +EAEN K E ++W + + + LEE S+ +
Sbjct: 570 LKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTV 629
Query: 2520 SQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT 2579
+ L+ WL + E MLN + + + QQH +N+A ++
Sbjct: 630 ASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIE 676
Query: 2580 GPGDVSLSTSQVQKELQSINQKWVEL--------------------TDKLNSRSSQIDQA 2619
+ + + ++++L +N +W EL TD + + S+ +A
Sbjct: 677 TCDE--MVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEA 734
Query: 2620 IVKSTQYQEL-----------LQDLSEKVRAVGQRLSV--QSAISTQPEAVKQQLEETSE 2666
K ++ E+ L+D+ ++V + + + ++A E+ +++ +E
Sbjct: 735 HKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFA 794
Query: 2667 IRSDLEQLDHEVKEAQT--LCDELSVLIGEQYLKDE-----------------LKKRLET 2707
S L++ +VKE + L + +LI + L+ + L++ ++
Sbjct: 795 TMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQS 854
Query: 2708 VALPLQGLEDLAADRIN-------------------------------RLQAALASTQ-Q 2735
AL Q ++L A + N RLQ +A
Sbjct: 855 SALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVA 914
Query: 2736 FQQMFDELRTWLD--DKQSQQAKNCPIS-AKLERL----QSQLQENEEFQKSLNQHSGSY 2788
FQ M + W + S+ K S A+LE++ Q L+E + ++ L +H+ +
Sbjct: 915 FQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFF 974
Query: 2789 EVI-------VAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQ 2841
+ + L + P +E++ LQ + +L W++L + LK ++
Sbjct: 975 SQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVE 1034
Query: 2842 KAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNE------VEKRRS 2895
K + + +E+C+ ++ + E + + ++ EKR
Sbjct: 1035 KNR--------FLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQ 1086
Query: 2896 LLEILNSAADILINSSEADEDG-----IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRL 2950
L+E L + + D G +++ +A I D+ +L ++ T R
Sbjct: 1087 LIEEL--CVKLPVRDPVRDTPGTCHVTLKELRAAI----DSTYRKLMEDPDKWKDYTSRF 1140
Query: 2951 REFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQ---VDYL 3007
EF E +++G K G + + E RA +E+ + + + +L
Sbjct: 1141 SEFSSWISTNETQLKGIK---------GEAIDTANHGEVKRAVEEIRNGVTKRGETLSWL 1191
Query: 3008 RNFTQGLVEDAPD------GSDASQLLHQAEVAQQEFLEVKQRVNS--GCV----MMENK 3055
++ + L E + + G + ++L + EV++ +++ CV +++N
Sbjct: 1192 KSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNS 1251
Query: 3056 LEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIE 3115
LE + V+E ++ D ++ + + L Q + R+ K V + +
Sbjct: 1252 LEELISGSKEVQEQAEKILDTENLFEAQQLL------LHHQQKTKRISAKKRDVQQQIAQ 1305
Query: 3116 ASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQ-LELTLGRVEDFYRK 3174
A + E L + G +L L+ L+ L ER + RQE+ +++TL + E F
Sbjct: 1306 AQQGEGG--LPDRGHEELRKLESTLDGL--------ERSRERQERRIQVTLRKWERFETN 1355
Query: 3175 LKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL 3234
+ + + +++ + +E ++ +L K F K + + + + L
Sbjct: 1356 KETVVRYLFQTGSSHE-RFLSFSSLESLSSELEQTKEFSK--------RTESIAVQAENL 1406
Query: 3235 IQSAGK----DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLL 3290
++ A + + Q L+ + I + L + + I ++ F E L
Sbjct: 1407 VKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLS 1466
Query: 3291 SWLADTE-ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAE 3349
W+ + E EL A + SA + QI + K+ + ++ + +++ L+ E AQ
Sbjct: 1467 VWITEKEKELNALETSSSA----MDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVT 1522
Query: 3350 LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKL 3409
+ +I +L + EL A + + L ++F E I +S E KL
Sbjct: 1523 TGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKL 1582
Query: 3410 ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKI 3469
A + + + + + H L + +E+ ++ + + + + S ++
Sbjct: 1583 AVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAA----- 1637
Query: 3470 DSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD 3529
+LQ +Y +I R + L+ L++ + ++ L WL E K SS + D D
Sbjct: 1638 -ALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEM-DISAD 1695
Query: 3530 VLHRQHADHL--ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYAD 3587
+ + L AL E+V++ + ++ ++L + ++V +++ L+ + R+ D
Sbjct: 1696 RVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRD 1755
Query: 3588 ITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQ 3647
+ +K + L+ +F + W++ EL T+ S Q+ R
Sbjct: 1756 LPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVA--LTRH 1813
Query: 3648 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 3707
K+ EV + + + L +L E L L A + ++L + Q V+
Sbjct: 1814 KDHAAEVESKK---GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA-SQVVER 1869
Query: 3708 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR------LEQDQTTAQLQVQKAFSI 3761
A+ ++ Q+ + + + ++ + A + +E+D A LQ KA
Sbjct: 1870 RQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDA-LQNAKALES 1928
Query: 3762 DIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQ 3821
+ S+D + S EQ+T + + L + E I L + + +
Sbjct: 1929 AAV----SLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALA 1984
Query: 3822 VLVNQFWETYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHI 3879
VL F + EEL IE E R +L P + L+Q+ QL + + H+ +
Sbjct: 1985 VLKKAFQDQKEELLKSIEDIEERTDKERLKEPT--RQALQQRLRVFNQLEDELNSHEHEL 2042
Query: 3880 DKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFH 3939
L Q+ + + V+ + + E + K + + + + E+
Sbjct: 2043 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQ---GQCCGLIDLMREYQ 2099
Query: 3940 DKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEE 3999
+ + + LEN SS + I + D ++ S +++A ++ Q + +G+
Sbjct: 2100 NLKSAVSKVLENASSVIVTRTTIKDQED-LKWAFSKHETAKNKMNYKQKDLDNFTSKGKH 2158
Query: 4000 LIG---RSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMA 4056
L+ + +D L +++ +D+ W D+ + EE +D L ++ W D+
Sbjct: 2159 LLSELKKIHSSDFSLVKTDMESTVDK----WLDVSEKLEEN----MDRLRVSLSIWDDVL 2210
Query: 4057 ALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE---ETDGLHEELEFIRILGADL 4113
+ I+ + + I S + + A E +KE E LE + DL
Sbjct: 2211 STRDEIEGWSNNCVPQMAENI--SNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDL 2268
Query: 4114 IFACGETEKPEVRKSID-EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD 4172
E P + I+ ++ E+ + + L+D + Q + + + W
Sbjct: 2269 KELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFT 2328
Query: 4173 NTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDR 4232
L + N + L ++K+ + E+ QQ + + +K +
Sbjct: 2329 KVEESL-----MNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRK-YHSAEL 2382
Query: 4233 DIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQR 4292
+ + +T L E + + + Q L+ +L F +++E W +
Sbjct: 2383 ESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFLGAKAAAKESS 2440
Query: 4293 PISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMN 4352
+GD KV+E +L + + V Q+ ++ V + G L + SS++ ++ N
Sbjct: 2441 DRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKAN 2500
Query: 4353 QCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSA---SKPTGGLPET 4409
+ +++ L++ + +Q LQ + F + L + ME + + + +PE
Sbjct: 2501 EEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK 2560
Query: 4410 AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVS 4469
E M L +L A E+ ++L +G+ LLS + G+G + LL +++
Sbjct: 2561 KNEVHKVEMFL-GELLAARESLDKLSQRGQ--LLSEEGHGAGQEGRLCSQLLTSHQNLLR 2617
Query: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTV---LSQIEE 4526
E+ +S + AL + +LQ W+ + L A +T+ LSQI++
Sbjct: 2618 MTKEKLRS-CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQD 2676
Query: 4527 HKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGR 4586
+ E + I G Q S K+ +I+ L +++ W ++ S+
Sbjct: 2677 ILLMKGEGEVKLNMAI---GKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQS 2733
Query: 4587 SLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGK 4646
+L+ + + E +L W+E + ++ L+ + + L +
Sbjct: 2734 TLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDH 2793
Query: 4647 QPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSG 4706
I R L EKT ED D E++ +++ + + E+ K+EE +
Sbjct: 2794 TRALHRLIAKSRELYEKT---EDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHL 2850
Query: 4707 QFMDALQALVDWLYKVEPQLAEDQPVHGD-------LDLVMNLMDAHKVFQKELGKRTGT 4759
++DA+ DWL+ + +L + GD L + L+D+ ++ L +
Sbjct: 2851 MYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESL 2910
Query: 4760 VQVLKR----SGRELIENS-----RDDTTWVKGQLQELSTRWDTVCKLSVSKQ------S 4804
+K+ SG EL+ D W Q S + V ++++S+Q +
Sbjct: 2911 APEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVA 2970
Query: 4805 RLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDT-----EALQSLIDTHKEFMK 4859
+LEQAL+Q +L W A+Q G D+ Q ++D ++
Sbjct: 2971 QLEQALEQFSA------LLKTW---AQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEP 3021
Query: 4860 KVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETAL 4919
+ E+ + +N ++T ++ + + + A + Q E L
Sbjct: 3022 RTEDLKSQLNELCRFSR---------DLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQIL 3072
Query: 4920 SELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQ 4976
+ A + W+ A+ T + IPQNI V + + Q F+ E Q
Sbjct: 3073 QQRFRKA--FRDFQQWLVNAKITTAKCFD--IPQNISEVSTSLQKIQEFLSESENGQ 3125
Score = 211 bits (538), Expect = 1e-53
Identities = 155/457 (33%), Positives = 233/457 (50%), Gaps = 77/457 (16%)
Query: 71 RVADERDRVQKKTFTKWVNKHLMKVRKH--INDLYEDLRDGHNLISLLEVLSGIKLPREK 128
R+ DE++ VQK+TFTKW+N HL K + ++DL+ED++DG L++LLEVLSG KLP E+
Sbjct: 20 RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
Query: 129 GRM--RFHRLQNVQIALDFLKQRQ-------VKLVNIRNDDITDGNPKLTLGLIWTIILH 179
GR R H + N+ AL FL+ R+ +KLVNI + DI DG P + LGL+WTIIL+
Sbjct: 80 GRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILY 139
Query: 180 FQISDI-------------------YISGESGDMSAKEK------------LLLWTQKVT 208
FQI ++ +S E+ +K K LL W Q
Sbjct: 140 FQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTA 199
Query: 209 AGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAE-RLGV 267
TGI+ +F W G F+++IH RP+LVD+E V+ +SNRENLE AF +AE LG+
Sbjct: 200 GKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGI 259
Query: 268 TRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGG-EGISATEVDSRWQEYQSRVDS- 325
RLLD EDVDV PDEKS++TYV+ +P + +G E+ + + + V +
Sbjct: 260 PRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF 319
Query: 326 ----------LIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIE 375
+ WI+Q ++ ++ ++ K Y + HF+ + E ++ +IE
Sbjct: 320 KREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDK--YQSFKHFR----VQYEMKRKQIE 373
Query: 376 ELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPA--------VERLE 427
L + L G++ L Q + +L ++ +KSL PA + R E
Sbjct: 374 HLIQPLH---RDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSL-PAPLGTIGAWLYRAE 429
Query: 428 LLLQIANKIQ----NGALNCEEKLTLAKNTLQADAAH 460
+ L+ +Q A + KL K+ LQ AH
Sbjct: 430 VALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAH 466
Score = 159 bits (401), Expect = 9e-38
Identities = 465/2549 (18%), Positives = 965/2549 (37%), Gaps = 373/2549 (14%)
Query: 1124 SSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQE 1183
SS S R ++L + D V ST +L+ DV R LL + E L +
Sbjct: 6295 SSQSGGAKRQSIHLEQKLYDGVSATST-WLD-----DVEERLFVATALLPEETETCLFNQ 6348
Query: 1184 EVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLE 1243
E++ D+ + K+KN E V+ + + L +L
Sbjct: 6349 EILAKDIKEMSEEMD---------KNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDS 6399
Query: 1244 RYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKP 1303
++ Q++ER +++ Q++L+ + L D + + + E +++
Sbjct: 6400 VVNQRCHQMKERLQQILNF----QNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAI 6455
Query: 1304 GQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYS------------------- 1344
QAED L + A E++R KL Q Q+ S
Sbjct: 6456 QQAEDG------LKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSG 6509
Query: 1345 -----TIVKDYELQLMTYKAFVES-QQKSPGKRRRMLSSSDAITQEFMDLRTRY-----T 1393
T+ YE L +E+ Q+K G ++ ++SS + I Q+ +D Y +
Sbjct: 6510 LNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEI-QQLLDKHKEYFQGLES 6568
Query: 1394 ALVTLTTQHVKYISDALRR--------LEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT 1445
++ T K IS A+++ + + V++ + VE L W S L +
Sbjct: 6569 HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETW-SHLDEDQ 6627
Query: 1446 QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKK 1505
Q + E ES+ ++E+ +E+ + + + +K+S +++ + K+
Sbjct: 6628 QELSRQLEVVESSIPSVGLVEE---NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 6684
Query: 1506 --------QISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE 1557
+ QLN L + + + + +L +L++ L H T ++ +
Sbjct: 6685 LLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS----------ESA 6734
Query: 1558 DLCSWVGQAERALA--GHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEG 1615
DL W+ A+ L Q T Q+L ++ + + + ++ +++ ++V+
Sbjct: 6735 DLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQ 6794
Query: 1616 FMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAA 1675
+ +L + LR +L + Q+ L Q++L + LQ + S+ A
Sbjct: 6795 LL-----RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ-----LQMDKLPSRHA 6844
Query: 1676 KELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAP 1735
I ++ W++ L+ N+ ++ + + GY +++
Sbjct: 6845 ---------ISEVMSWIS--------LMENV--------IQKDEDNIKNSIGYKAIHEYL 6879
Query: 1736 EK-----LDKQCEMMKAR--HQELLSQQQNFILATQSAQA-FLDQHG---------HNLT 1778
+K +D C+ + +Q +L + + +S + F +Q G L
Sbjct: 6880 QKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV 6939
Query: 1779 PEEQQMLQQKLGELKEQYS------TSLAQSEAELKQVQTLQDE--LQKFLQDHKEFESW 1830
E+ Q+L+ L E + T E LKQ + D+ +Q L+D ++ E
Sbjct: 6940 TEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDL 6999
Query: 1831 LERSEKELENMHKGGSS---------PETLPSLLKRQG------------------SFSE 1863
++ EKE+E + + G + + S L+ G S +
Sbjct: 7000 IKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLD 7059
Query: 1864 DVISHK------------------------GDLRFVTISGQKVLDMENSF-KEGKEPSEI 1898
SHK G L V + + ++++ K+ + +
Sbjct: 7060 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKF 7119
Query: 1899 GNLVKDKLKDATERYT-ALHSKCTRLGSHLNMLLGQY-HQFQNSADSLQAWMQ------A 1950
G++ LK+ T L + + N LL + Q Q+S LQ W +
Sbjct: 7120 GSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQ 7179
Query: 1951 CEANVEKLLSDT-----VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI- 2004
C + V++ T A++ + +++AT Q +L + V+ ++ E
Sbjct: 7180 CASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQL 7239
Query: 2005 -EGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2063
+ A +Q S+ H +L +L ++ + LQ + ++ +SLE+L I E
Sbjct: 7240 KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVE 7299
Query: 2064 VEQNLEGKQVSSLSS-GVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAA 2122
E+ L+G+ S S IQE + + L+ E+ R
Sbjct: 7300 AEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIK-- 7357
Query: 2123 VLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLA---S 2179
++ +++ + + Q E+ S L+ L Q + F +F+ + LA S
Sbjct: 7358 ----RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEIS 7413
Query: 2180 GNQPDQDITHFFQQIQELNL---EMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2236
GN H +Q + L EM +Q+ L ++ L G D + ++
Sbjct: 7414 GNYQ-----HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTL 7468
Query: 2237 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETE-------GSIPPTETS 2289
L + + + ++R S Q +R++ +KWL E GS+P
Sbjct: 7469 LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIP--- 7525
Query: 2290 MSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSV 2349
++ ++L D+ K E++ + L +E GK +L S
Sbjct: 7526 ---------LQQARTLFDEVQFK----EKVFLRQQGSYILTVEA------GK--QLLLSA 7564
Query: 2350 GSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANS 2409
S + +Q +++++ K++ L E+++ L +L E+ K
Sbjct: 7565 DSGAEAA-----------LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD 7613
Query: 2410 VLQWLES-KEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLL 2468
L+ L + K+++ +S+ E ++ + N + + ++ +K+ L+
Sbjct: 7614 SLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENA--VGSWTDDLTQLSLLKDTLSA-- 7669
Query: 2469 VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME 2528
Y ++ + + E L +WE R++Q+ E + A F +L WL +
Sbjct: 7670 --YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQ 7727
Query: 2529 KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLST 2588
E + G + I+ M+ K+ Q + + + Q +Q+ E
Sbjct: 7728 MESKVSQNGDILIE-EMIEKLKKDYQEEIAIAQENKIQLQQMGERL-----AKASHESKA 7781
Query: 2589 SQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQS 2648
S+++ +L +N +W L D + +R ++ + +V Q + + L + + L+
Sbjct: 7782 SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPI 7841
Query: 2649 AI-STQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDEL---SVLIGEQYLKDELKKR 2704
S E ++++L E E++ D+E+ V LC+ L D +++
Sbjct: 7842 VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA 7901
Query: 2705 LETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKL 2764
+ + + ++ +R +++ Q+F + WL K S++ P S+ +
Sbjct: 7902 TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL--KSSERTAAFPSSSGV 7959
Query: 2765 --ERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT-----LQNQLVE 2817
+ +L++ E FQ+ +++ E+I + L E RT L+ + E
Sbjct: 7960 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL------ARENRTDSACSLKQMVHE 8013
Query: 2818 LKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLE 2877
W+ L K+ RLK + + ++++ + ++ W+ + +++ + ++
Sbjct: 8014 GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE-HFSECDVQ 8072
Query: 2878 SSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQ 2937
+ + + KA E+ + +E + + + LI SE + I I + +D + Q
Sbjct: 8073 AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAI------IEEELDELRRYCQ 8126
Query: 2938 AKTGSLEEMTQRL-------REFQESFKNIEKKVEGAKHQLEIFDA-----LGSQACSNK 2985
G +E ++L E S + +E + A L D L Q SN
Sbjct: 8127 EVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 8186
Query: 2986 NL---EKLRAQQEVLQA--------LEPQVDYLRN------FTQGLVEDAPDGSDASQLL 3028
+L + LR+++ LE DY + ++ L + +G D
Sbjct: 8187 SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 8246
Query: 3029 HQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGR 3088
+ V + + + + + + EN ++ H + QL D D I +
Sbjct: 8247 LRGAVGLSDVM-IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD--DSRFQIQQ 8303
Query: 3089 DTDSLQSQIED-VRLFLNKIHVLKLDIEASEA-----ECRHMLEEE-----GTLDLLGLK 3137
+ ++S+ L + +KL E S + H L+EE G ++L +
Sbjct: 8304 TENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTE 8363
Query: 3138 RELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG----LNDATTAAEEAEALQW 3193
+ + + L + +++ +++ L + + F L L D E+ + L+
Sbjct: 8364 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE- 8422
Query: 3194 VVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEE 3253
+ T+++ I Q+ K QK VD + + +N Q+ K+ + L+ + +
Sbjct: 8423 -LSTDIQTIELQIKKLKELQKA-VDHRKAIILSINLCSPEFTQADSKES--RDLQDRLSQ 8478
Query: 3254 INARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVV 3313
+N RW+ + + + LQ+AL+ C F + LL L + + P +
Sbjct: 8479 MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAE 8538
Query: 3314 KAQIQEQKLLQ--RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELL 3371
Q ++L+Q L + + V LQ ++ +AE D + ++ + +R LL
Sbjct: 8539 ILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLL 8598
Query: 3372 SKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANS-EPVGTQTAKIQQQIIRHK 3430
+ + K+LE +L ++ + + +S + S E + S P ++ +Q+ R K
Sbjct: 8599 KEVSRHIKELEKLLDVS----SSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGK 8654
Query: 3431 ALEEDIENHATDVHQAVKIGQSLSSLTSP 3459
+ H G S SSL+ P
Sbjct: 8655 CSLSQPGPSVSSPHSRSTKGGSDSSLSEP 8683
Score = 154 bits (389), Expect = 2e-36
Identities = 445/2581 (17%), Positives = 976/2581 (37%), Gaps = 297/2581 (11%)
Query: 2546 LNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVEL 2605
L + Q + ++E +R+Q E L + L G +SL + V+ Q W +
Sbjct: 351 LQDKYQSFKHFRVQYEMKRKQIEHLIQP----LHRDGKLSLDQALVK-------QSWDRV 399
Query: 2606 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 2665
T +L Q+D+++ + L A+ + ++VQ ++++LE+
Sbjct: 400 TSRLFDWHIQLDKSL--PAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHK 457
Query: 2666 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKR---LETVALPLQGLEDLAADR 2722
++ + + E + + L+D ++ T L L +E L
Sbjct: 458 DLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKY 517
Query: 2723 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 2782
RL + L + +L++W+ +++ +E+L E K
Sbjct: 518 --RLLSLLVLAES------KLKSWIIKYGRRES--------VEQLLQNYVSFIENSKFFE 561
Query: 2783 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQK 2842
Q+ +Y+++ E + + EE + + E W LS + +S L++ +
Sbjct: 562 QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISN 621
Query: 2843 AQKYQWHVEDLVPWIEDCK--------AKMSELRVTLDPVQLESSLLRSKAMLNEV---- 2890
+Y V L W+ED + AK R +Q +++ + L E
Sbjct: 622 WDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEM 681
Query: 2891 ---EKRRSLLEILNSAADILI---NSSEADE-DGIRDEKAGINQNMDAVTEELQAKTG-- 2941
+ ++ LL + ++ + ++ADE D ++ E + A E K
Sbjct: 682 VSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEP 741
Query: 2942 -------------SLEEMTQRLREFQESFKNIEKKV---------EGAKHQLEIFDALGS 2979
LE++ QR+ +K I K E K L
Sbjct: 742 LEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKE 801
Query: 2980 QACSNKNLEK--LRAQQEVLQALEPQVDYLRNFTQGL------VEDAPDGSDASQLLHQA 3031
Q K L Q++L LE + +F L + + +S L Q
Sbjct: 802 QLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQ- 860
Query: 3032 EVAQQEFLEVKQRVNSGCVMMENKLEGIGQF--------HCRVREMFSQLADLDDELDGM 3083
QE L ++ ++E + + +F H + Q+AD+ M
Sbjct: 861 --KHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSM 918
Query: 3084 GAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLK------ 3137
+ T + +E + K + ++E + LEE+G + L +
Sbjct: 919 ---VKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 975
Query: 3138 ----RELEALNKQCGKLTE-RGKARQEQLELTLGRVEDFYRKLKG-----LNDATTAAEE 3187
R L A K C +LT+ + Q+ L+ + ++ ++ L+G L E+
Sbjct: 976 QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEK 1035
Query: 3188 AEALQWVVGTEVEI-----INQQLADFKMFQKEQV-----DPLQMKLQQVNGLGQGLIQS 3237
L V E+ + Q K+ ++ +V P + +++ + + ++
Sbjct: 1036 NRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKL 1095
Query: 3238 AGKD--CDVQGLEH-DMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3294
+D D G H ++E+ A ++ +K+ + + ++ +F SW++
Sbjct: 1096 PVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFS-------SWIS 1148
Query: 3295 DTE---ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA 3351
E + I + +A + VK ++E ++ + R T+ L++ + + +
Sbjct: 1149 TNETQLKGIKGEAIDTANHGEVKRAVEE---IRNGVTKRGETLSWLKSRLKVLTEVSSEN 1205
Query: 3352 DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLAN 3411
+ +K +L L S + L++ + +K L + F + + + E+ ++
Sbjct: 1206 EAQKQGDELAKLSSSFKALVTLLSEVEKMLSN-------FGDCVQYKEIVKNSLEELISG 1258
Query: 3412 SEPVGTQTAKI---------QQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQ 3462
S+ V Q KI QQ ++ H+ + I DV Q +I Q+ ++
Sbjct: 1259 SKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQ--QIAQAQQGEGGLPDR 1316
Query: 3463 GVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEV----EDKL 3518
G E++ L++ ++ R+ + L F ++ V+ +L + E L
Sbjct: 1317 G--HEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFL 1374
Query: 3519 SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL 3578
S ++ ++ Q + E I + +N+ +K + ++ L+Q++
Sbjct: 1375 SFSSLESLSSEL--EQTKEFSKRTESIAVQAENL---VKEASEIPLGPQNKQ--LLQQQA 1427
Query: 3579 DGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL-ATSGGQSPTG 3637
IK + + T + ++T+E + F S +E L+ W+ E E+EL A S
Sbjct: 1428 KSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMD 1487
Query: 3638 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLV 3697
QI Q + +E++ ++ + + E +++ + V G + Q +
Sbjct: 1488 MQISQIKVTIQEIESKLSS----IVGLEEEAQSFAQFV----TTGESARIKAKLTQIRRY 1539
Query: 3698 SDTIGQRVDEIDAAI----QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQL 3753
+ + + ++ I + Q++E+ V+E + KL PI++ T
Sbjct: 1540 GEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAV--PIKICSSATETYK 1597
Query: 3754 QVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQ----EKTESLIQQYEAISLL 3809
+Q+ H D L S S I +K V + ++ +L QQYE I
Sbjct: 1598 VLQE--------HMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRR 1649
Query: 3810 NSERYARLERAQVLVNQFWETYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQ 3867
ER LE + + W+E E +A ++ A D ++ + + ++
Sbjct: 1650 AKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISA-DRVKVEGELQLIQA 1708
Query: 3868 LRESIAEHKPHIDKLLKIGPQLKEL-NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALD 3926
L+ + KLL++ L + + ++ +M++ ++ + + + + + +R L
Sbjct: 1709 LQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1768
Query: 3927 EAVSQSTQITE----FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVE 3982
V++ Q E F I+ L L+ S M + ++ +K E
Sbjct: 1769 SVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV---------ALTRHKDHAAE 1819
Query: 3983 LEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFL 4042
+E + ++L+ +L + D L +Q K + +E+ E R++
Sbjct: 1820 VESKKGELQSLQGHLAKLGSLGRAEDLHL----LQGKAEDCFQLFEEASQVVERRQLALS 1875
Query: 4043 DVLELAEKFWYDMAALLTTIKDTQDIVHDL---ESPGIDPSI--IKQQVEAAETIKEETD 4097
+ E + ++ +L ++ T + + + ES I+ + Q +A E+ D
Sbjct: 1876 HLAEFLQSH-ASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1934
Query: 4098 GLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAA 4157
G+ + ++ +G+ ++ R + D++ ER++ L Q+
Sbjct: 1935 GILSKAQYHLKIGS-------SEQRTSCRATADQLCGE--------VERIQNLLGTKQSE 1979
Query: 4158 VQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNH 4217
L+ F ++K TD +K+ + + ++ V+ Q+E E +H
Sbjct: 1980 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVF-NQLEDELNSH 2038
Query: 4218 QGEL--MLKKATDETDRDIIREP-----LTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270
+ EL + KA +D+ P + L+ W++ I Q + G + + ++
Sbjct: 2039 EHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREY 2098
Query: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4330
Q+ + L + ++ + I D + ++ +KH KN + Q ++ G
Sbjct: 2099 QNLKSAVSKVLENASSVIVTRTTIK-DQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGK 2157
Query: 4331 EL---LESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQ----------STLQQAQ 4377
L L+ D S +++ +E+ W V +K EE +L+ ST + +
Sbjct: 2158 HLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIE 2217
Query: 4378 GFHSEIEDFLLE-LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLD 4436
G+ + + E ++ +++ L A + + + EL+S++ +E L
Sbjct: 2218 GWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLET 2277
Query: 4437 KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4496
L + D L QK E K L++ +T+ + + +
Sbjct: 2278 PPDLQFIEAD--------------LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDI 2323
Query: 4497 INWLTLAEQSL-NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS 4555
W T E+SL N A N +++ K E+ + + I + N L
Sbjct: 2324 TTWFTKVEESLMNCAQ------NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2377
Query: 4556 QKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESH 4615
++ + + + + E V Q + SL ++ + K F E+ ++ +W A++
Sbjct: 2378 HSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWFLGAKAA 2435
Query: 4616 LDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDN 4675
+ + D ++ +L + ++ Q D + G+ L L + +
Sbjct: 2436 AKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAH-LSKQIVSSIQE 2494
Query: 4676 FLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGD 4735
+ + +++ + ++ + L++ G F D + L W++++E + +
Sbjct: 2495 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2554
Query: 4736 LDLVMNLMDAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL-QELSTRW 4792
+ + HKV F EL ++ L + G+ L E +G+L +L T
Sbjct: 2555 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHG--AGQEGRLCSQLLTSH 2612
Query: 4793 DTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLID 4852
+ +++ K + AL++ E + + + W+ + L + + L+ +
Sbjct: 2613 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLS 2672
Query: 4853 THKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQ 4912
++ + E V +N A+ GE L + + I+ + ++ + ++++ + Q
Sbjct: 2673 QIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQ 2732
Query: 4913 QRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPI-PQNIDRVKALIAEH-QTFME 4970
LE+ +S+ E +L W++ ++ Q+ + P+ PQ + K ++ +H Q+ +
Sbjct: 2733 STLESVISQWNDYVERKNQLEQWME----SVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2788
Query: 4971 E 4971
E
Sbjct: 2789 E 2789
Score = 143 bits (361), Expect = 4e-33
Identities = 377/2142 (17%), Positives = 819/2142 (38%), Gaps = 260/2142 (12%)
Query: 3008 RNFTQGLVEDAPDGSDASQLLHQAEVAQQ---EFLEVKQRVNSGCVMMENKLEGIGQFHC 3064
R + L+++ + S+ Q EV Q + E+ + + EN ++ + +
Sbjct: 540 RESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTA 599
Query: 3065 RVR----EMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAE 3120
+ R E+ S + L++ + G SLQ+ +ED LN+ K D +
Sbjct: 600 QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRN--- 656
Query: 3121 CRHMLEEEGTLDLLG--------------LKRELEALNKQCGKLTERGK--ARQEQLELT 3164
H +++ ++ G LK++L LN + +L K A+ ++++
Sbjct: 657 LPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRM 716
Query: 3165 LGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKL 3224
D L AT A ++ V V+++ Q L D + Q+ V Q K+
Sbjct: 717 KKEYTDCVVTLSAF--ATEAHKKLSEPLEVSFMNVKLLIQDLEDIE--QRVPVMDAQYKI 772
Query: 3225 --QQVNGLGQGLIQSAGKD--CDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCG 3280
+ + + + Q GK+ + L+ + ++ ++ L + Q + L+E
Sbjct: 773 ITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMT 832
Query: 3281 KFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAE 3340
F D+L + + ++ + SA +K Q+ + L ++ K T+ +++
Sbjct: 833 SFYDSLGKINEIIT----VLEREAQSSALFK------QKHQELLACQENCKKTLTLIEKG 882
Query: 3341 GGRIAQSAELA------DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHET 3394
+ + L+ D+ ++ Q+ + + ++ K +K +E L K+F E+
Sbjct: 883 SQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEES 942
Query: 3395 AEPISDFLSVTEKKLANS----EPVGTQT---AKIQQQIIRH--KALEE--DI--ENHAT 3441
+ L + ++ L E + T +++ Q+++ KA +E DI E
Sbjct: 943 RAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQ 1002
Query: 3442 DVHQAV-KIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC----RKAALLDQA--- 3493
+ +AV K+ + L A +L KID + R+ + C R+ L+ Q
Sbjct: 1003 GLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSE 1062
Query: 3494 --LSNARLFGEDE------------VEVLNWLAEVEDKLSS------VFVKDFKQ--DVL 3531
+ R+F D+ +E L V D + V +K+ + D
Sbjct: 1063 KIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDST 1122
Query: 3532 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQ---------------- 3575
+R+ + ++ +R I + LK GE +
Sbjct: 1123 YRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVT 1182
Query: 3576 ---EKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGG 3632
E L +K+R +T SS+ +Q +LA K S+++ L L EVE+ L+ G
Sbjct: 1183 KRGETLSWLKSRLKVLTEVSSEN-EAQKQGDELA-KLSSSFKALVTLLSEVEKMLSNFGD 1240
Query: 3633 QSPTGEQIPQFQQRQKELKKEVMEH-RLVLDTVN--EVSRALL----------------E 3673
E + + KEV E +LDT N E + LL +
Sbjct: 1241 CVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQ 1300
Query: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIG-------QRVDEIDAAIQRSQQYEQAADAEL 3726
+A++G L +E+ + + T+ ++ I +++ +++E + +
Sbjct: 1301 QQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVV 1360
Query: 3727 AWVAET---KRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT 3783
++ +T + ++ + + +++L+ K FS + L SEI
Sbjct: 1361 RYLFQTGSSHERFLSFSSL----ESLSSELEQTKEFSKRTESIAVQAENLVKEASEI--P 1414
Query: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 3843
G + K +LQ++ +S+ +Q + + E +E + + F +E LS WI E
Sbjct: 1415 LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEK 1474
Query: 3844 LIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEK 3903
+ L + + + ++ Q++ +I E + + ++ + + + +
Sbjct: 1475 ELNALETSSSAMDM------QISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR 1528
Query: 3904 YQKAENMYAQIKEEVRQRALALDEAV-SQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962
+ + EE+R+ A L+ + +Q +F + + + +++ +L +P I
Sbjct: 1529 IKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKI 1588
Query: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4022
+ + + + ++ LE L + A +++ R + A ++
Sbjct: 1589 CSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQ------ 1642
Query: 4023 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4082
+EDI RA+ER+ ++L ++ ++++ LT ++ + SP +D S
Sbjct: 1643 ----YEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEA---KASSPEMDISAD 1695
Query: 4083 KQQVEAA----ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWEN 4138
+ +VE + ++ E + L L + + ++ +++++ W +
Sbjct: 1696 RVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRD 1755
Query: 4139 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG-----TDLNTVKD 4193
L + +R+ L+ + Q+ + L + W+ + +L T + L KD
Sbjct: 1756 LPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKD 1815
Query: 4194 QLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKI 4253
E++ K E+ Q + KL G D +++ + L+E + +
Sbjct: 1816 HAAEVESKKGELQSLQGHLAKLGSLGRA--------EDLHLLQGKAEDCFQLFEEASQVV 1867
Query: 4254 AHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPIS-GDPKVIEVELAKHHVLK 4312
RQ AL L +F + L L + ++A ++ + +IE +L
Sbjct: 1868 ERRQL----ALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDL------- 1916
Query: 4313 NDVLAHQATVETVNKAGNELLESSA-----GDDASSLRSRLEAMNQCWE----SVLQKTE 4363
ND L + +E+ + + +L + G R A C E L T+
Sbjct: 1917 NDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTK 1976
Query: 4364 EREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQ 4423
+ E + L++A F + E+ L + +E + + L E R+ L + +++Q
Sbjct: 1977 QSEADALAVLKKA--FQDQKEELLKSIEDIEERTDKER----LKEPTRQALQQRLRVFNQ 2030
Query: 4424 LKAKEETYNQLLD--KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4481
L+ + ++ L K + +++ D + ++ + LE W + E + +
Sbjct: 2031 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCG 2090
Query: 4482 ALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQ------IEEHKVFANEVN 4535
++L E+QN + + L AS + T+ Q +H+ N++N
Sbjct: 2091 LIDLMREYQNLK-------SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMN 2143
Query: 4536 AHRDQIIELDQTGNQLKFLSQK---QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDAR 4592
+ + G L +K D L+K + S +W V ++ L++
Sbjct: 2144 YKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEK-------LEENM 2196
Query: 4593 KRAKQFHEAWKKLIDWLEDAESHLDSEL-----EISNDPDKIKLQLSKHKEFQKTLGGKQ 4647
R + W ++ ++ E ++ + ISN + ++ + KEF+ + K
Sbjct: 2197 DRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAE-ELLKEFESEVKNKA 2255
Query: 4648 PVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQ 4707
+ LKE T E L ++ K + + + L++ S Q
Sbjct: 2256 LRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQ 2315
Query: 4708 FMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVL---- 4763
+ + W KVE L + + + + D K Q + + T + L
Sbjct: 2316 VEKFINDITTWFTKVEESLMNCAQ-NETCEALKKVKDIQKELQSQQSNISSTQENLNSLC 2374
Query: 4764 -KRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHM 4822
K EL R T +K + + V +L Q+ L+++L++ F +++
Sbjct: 2375 RKYHSAELESLGRAMTGLIK--------KHEAVSQLCSKTQASLQESLEKH--FSESMQE 2424
Query: 4823 LLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVC 4882
EW A+ + D++ L++ + + + V + + +++ G+ + A
Sbjct: 2425 FQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHL 2484
Query: 4883 HPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETT 4942
+++I+ IT F+ L + +Q L+ SEL + + +L WI E
Sbjct: 2485 SKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER 2544
Query: 4943 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTK 4984
+ Q+I K + + + F+ E+ + +D++++
Sbjct: 2545 FNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQ 2586
Score = 128 bits (322), Expect = 1e-28
Identities = 348/1922 (18%), Positives = 743/1922 (38%), Gaps = 191/1922 (9%)
Query: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGT-EVEIINQ 3204
Q + ER EL L ++E K + L+ A E++ W++ E + Q
Sbjct: 488 QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLA--ESKLKSWIIKYGRRESVEQ 545
Query: 3205 QLADFKMFQKEQ--VDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3262
L ++ F + + ++ Q + + +++ G + + + M E A+W L+
Sbjct: 546 LLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLS 605
Query: 3263 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3322
+V + L+E + + ++ + + L +WL D E+++ + ++ +
Sbjct: 606 VEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDF---------FRN 656
Query: 3323 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3382
L + A D G + ++ + + QL L RW EL + + Q +
Sbjct: 657 LPHWIQQHTAMND----AGNFLIETCDEMVSRDLKQQLLLLNGRWRELFME-VKQYAQAD 711
Query: 3383 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3442
++ + K++ + +S F + KKL+ V K+ Q + EDIE
Sbjct: 712 EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDL------EDIEQRVPV 765
Query: 3443 VHQAVKIGQSLSSL---TSPAEQG-VLSEKIDSLQARYSEIQDRCCRKAALLD--QALSN 3496
+ KI + L SP E+G + + L+ + +++++ C L + Q L
Sbjct: 766 MDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKE--CYSPLLYESQQLLIP 823
Query: 3497 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQ-HADHLALNEEIVNRKKNVDQA 3555
+ + L ++ +++ +V ++ + L +Q H + LA E N KK +
Sbjct: 824 LEELEKQMTSFYDSLGKI-NEIITVLEREAQSSALFKQKHQELLACQE---NCKKTLTLI 879
Query: 3556 IKNGQALLKQTTGEEVL------LIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKF 3609
K Q++ K T VL +Q ++ I + + + + +E +L KF
Sbjct: 880 EKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKF 939
Query: 3610 QSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR 3669
+ + EL LR +E L G + +R E ++ + VL+ +
Sbjct: 940 EESRAELEKVLRIAQEGLEEKGDPE-------ELLRRHTEFFSQLDQR--VLNAFLKACD 990
Query: 3670 ALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV 3729
L +++P + ++GL + V ++Q+K D G+ + L
Sbjct: 991 ELTDILPEQEQQGLQEAVRKLHKQWK---DLQGEAPYHL---------------LHLKID 1032
Query: 3730 AETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQK 3789
E R L ++ R E D+ T +L Q+ I H+ + H C E++
Sbjct: 1033 VEKNRFLASVEECRTELDRET-KLMPQEGSEKIIKEHRVFFSDKGPHH-----LC-EKRL 1085
Query: 3790 TVLQEKTESL--------------IQQYEAISLLNSERYARLERAQVLVNQFWETYEELS 3835
+++E L + E + ++S Y +L + + E S
Sbjct: 1086 QLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDS-TYRKLMEDPDKWKDYTSRFSEFS 1144
Query: 3836 PWIEETRALIAQLPSPAID---HEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL 3892
WI + + AID H ++++ EE+R E + LK+ ++
Sbjct: 1145 SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS- 1203
Query: 3893 NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL 3952
E + QK + A++ + L E + + E + +LE L
Sbjct: 1204 --------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1255
Query: 3953 SSRLRMPPLIPAEVDKI--RECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4010
S + + + +KI E + + + + ++ A KR ++ I ++Q +
Sbjct: 1256 ISGSKE---VQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1312
Query: 4011 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4070
L + ++L ++ + ++ E +E + L E+F T K+T +V
Sbjct: 1313 LPDRG-HEELRKLESTLDGLERSRERQERRIQVTLRKWERF--------ETNKET--VVR 1361
Query: 4071 DLESPGI--DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKS 4128
L G + + +E+ + E+T + E I + +L+ E K
Sbjct: 1362 YLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQ 1421
Query: 4129 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT-------- 4180
+ + K+ KE+++KLED ++ ++ + ++ +D + L
Sbjct: 1422 L------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKE 1475
Query: 4181 MPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK-KATDETDRDIIREPL 4239
+ + T + + Q++++K E+ + + L + + + T E+ R I+ L
Sbjct: 1476 LNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKL 1533
Query: 4240 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4299
T+++ E L E + + G L +F+ L ++ ++ E+ L I
Sbjct: 1534 TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1593
Query: 4300 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4359
L +H L + + + + + + +++ + S A+ Q +E +L
Sbjct: 1594 ETYKVLQEHMDLCQALESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYEDIL 1647
Query: 4360 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETARE-QLDTHM 4418
++ +ER+ L++ L Q E+ FL L R E++ S+ + E +L
Sbjct: 1648 RRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQ 1707
Query: 4419 ELYSQLKAKEETYNQLLD--KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4476
L +++ ++ Y++LL + + S+DD + + L+++W + + +R
Sbjct: 1708 ALQNEVVSQASFYSKLLQLKESLFSVASKDDV---KMMKLHLEQLDERWRDLPQIINKRI 1764
Query: 4477 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 4536
+ L+ + +F L F W+ L L S S++ + V + HK A EV +
Sbjct: 1765 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV--ALTRHKDHAAEVES 1822
Query: 4537 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 4596
+ ++ L +L L + +D+ L++ +E+ Q +ER R L A
Sbjct: 1823 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ-VVER-RQL--ALSHLA 1878
Query: 4597 QFHEAWKKLIDWLEDAESHLDSELEIS-NDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 4655
+F ++ L L +++ ++ N+ D I+ L+ + K L D +
Sbjct: 1879 EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILS 1938
Query: 4656 TGR-ALKEKTLLPEDSQK--LDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDAL 4712
+ LK + S + D GEV ++ + G +Q + + + F D
Sbjct: 1939 KAQYHLKIGSSEQRTSCRATADQLCGEV-ERIQNLLG---TKQSEADALAVLKKAFQDQK 1994
Query: 4713 QALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIE 4772
+ L+ + +E + +++ + + + EL + LK +++ +
Sbjct: 1995 EELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ 2054
Query: 4773 NSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQ 4832
V ++ L WD +L Q + + +++ + + L A
Sbjct: 2055 KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2114
Query: 4833 TLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILA---VCHPDCITT 4889
+ R + D E L+ H+ K+ K+ D+++ + G+ +L+ H +
Sbjct: 2115 VIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSL 2173
Query: 4890 IKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQE 4949
+K + ++ +V +++ RL +LS +E+ W + + E
Sbjct: 2174 VKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGW----SNNCVPQMAE 2229
Query: 4950 PIPQNID---RVKALIAEHQT-------FMEEMTRKQPDVDRVTKTYKRKNIE-PTHAPF 4998
I N+D R + L+ E ++ +EE+ K D+ +T KN+E P F
Sbjct: 2230 NI-SNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELT-----KNLETPPDLQF 2283
Query: 4999 IE 5000
IE
Sbjct: 2284 IE 2285
Score = 93.2 bits (230), Expect = 6e-18
Identities = 304/1779 (17%), Positives = 664/1779 (37%), Gaps = 335/1779 (18%)
Query: 612 LPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLG----KLETQYCK 667
L +V++Q++ Q++ +E+ S+++ ++ + H ETL ++ ++
Sbjct: 7092 LEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNN 7151
Query: 668 LKET------SSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNY 721
L E SS + L +K S+ A + E EL + N +I+
Sbjct: 7152 LLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLK--AATNKDIAD---- 7205
Query: 722 FSELTMELEEKQDVFRSL---QDTAELLSLENHPAKQTVEAYSA-AVQS-QLQWMKQLCL 776
E+ +++ D+ + L +D+ L KQ V+A +A A+QS QL + LC
Sbjct: 7206 -DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 7264
Query: 777 CVEQHVKENTA-------YFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQ 829
+ K+ T+ Y F LE+++ ++ ++ + H++ LS + Q
Sbjct: 7265 LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ-DPSHSSDLSTI----Q 7319
Query: 830 DSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKN 889
+ M+E + + SS+A + R + +L R P N
Sbjct: 7320 ERMEELKGQMLKFSSMAPDLDR---LNELGYRLP------------------------LN 7352
Query: 890 DECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQ 949
D+ + + W +IS E FL+ Q++ + W +
Sbjct: 7353 DKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQ-------------HQTFLEKCETWME 7399
Query: 950 LHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVL 1009
V T+ ++ + +Y+ L+ R L
Sbjct: 7400 FLVQTEQ-------------------------------KLAVEISGNYQHLLEQQRAHEL 7428
Query: 1010 FSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYI--SELKNIRLRLEEYEQRV 1067
F A+ ++ + + Q L++ + +D++E K+ + ++ + + R ++ +
Sbjct: 7429 FQ-AEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 7487
Query: 1068 VKRIQSLASSRTDRDA---W--QDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQ- 1121
+I+ R + W + + L ++ LQQ R+ D V K FL Q
Sbjct: 7488 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 7547
Query: 1122 ---------------SPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKL----KTVDVI 1162
S S + L++EL + EK KL K +
Sbjct: 7548 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKC 7607
Query: 1163 VRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIA 1222
+ I D+ ++ ++ KLSQ +L H L K+ + +++
Sbjct: 7608 EKGIADSLEKLRTFKKKLSQ---------SLPDHHEELHAEQMRCKELENAVGSWTDDLT 7658
Query: 1223 KAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRA 1282
+ ++ + +S ++ + E+ LQ +W + QL +R+ ++ +
Sbjct: 7659 QLSLLKDTLSAYISADDISI--LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSE 7716
Query: 1283 CHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQ 1342
+ L +W+ + M+ +++ +L E++ +++ +K Q+
Sbjct: 7717 KNKELCEWLTQ-------MESKVSQNGDILIEEM----------------IEKLKKDYQE 7753
Query: 1343 YSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQH 1402
I ++ ++QL Q + S + I + + R+ L+ L
Sbjct: 7754 EIAIAQENKIQLQ--------QMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 7805
Query: 1403 VKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEK 1462
VK + + L +++ +K + L W++ + + K ++ S +I++
Sbjct: 7806 VKKLKETLVAVQQLDK-----------NMSSLRTWLAHI-ESELAKPIVYDSCNSEEIQR 7853
Query: 1463 AILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLC 1522
+ EQQ L ++ V+ + ++ L ++ E I + L++ + ++C
Sbjct: 7854 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7913
Query: 1523 DGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL 1582
S + +L+ + + QK L + + ED W+ +ER A +
Sbjct: 7914 AMSMER--RLKIEETWRLWQKFLDD-----YSRFED---WLKSSERTAAFPSSSGVIYTV 7963
Query: 1583 SALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQ 1642
+ ++ + Q + T + K EN+T + +L++ +H+ ++
Sbjct: 7964 A--KEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA----CSLKQMVHEGNQR 8017
Query: 1643 YEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQL 1702
++ LQ+ + L+ + + ET + D++L W+T +
Sbjct: 8018 WDNLQKRVTSILRRLKHFIGQREEFETAR--------------DSILVWLTEMDLQ---- 8059
Query: 1703 LTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILA 1762
LTN+ + + + + +KA QE+
Sbjct: 8060 LTNIEHFSECD------------------------VQAKIKQLKAFQQEISLNHNKIEQI 8095
Query: 1763 TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQV--QTLQDELQKF 1820
+ +++ P + +++++L EL+ + E K++ L D+
Sbjct: 8096 IAQGEQLIEKS----EPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDL 8151
Query: 1821 LQDHKEFES--------WLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVIS----- 1867
E E W +RS L + + +L L+ + S + S
Sbjct: 8152 SDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIP 8211
Query: 1868 ----HKGDL---------RFVTISGQKVLDMENSFKEG----------KEPSEIGNLVKD 1904
H DL R + ++ D ++ + G + P L ++
Sbjct: 8212 LEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTEN 8271
Query: 1905 KLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVE---KLLSD 1961
+K+ + ++AL S+ +LG L+ Q Q +N S + + + KLL +
Sbjct: 8272 AIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8331
Query: 1962 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET-TD 2020
+S + + K+L+ +L E + E P + H ET T
Sbjct: 8332 CSSS--------IDSVKRLEHKLKEEE----------------ESLPGFVNLHSTETQTA 8367
Query: 2021 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2080
++ ++ L + +++ + + Q L S+ +G+ E+ LE Q LS+ +
Sbjct: 8368 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 8427
Query: 2081 --IQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQL 2138
I+ + +L++ + +K+ + + F + ADS + LQ +L++++ R++++
Sbjct: 8428 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQ-ADSKESRDLQDRLSQMNGRWDRV 8486
Query: 2139 CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMEN----KSRMLASGNQPDQDITH-FFQQ 2193
C +E L+ L Q + F +S L +EN K+ ++ + D +I +Q
Sbjct: 8487 CSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQ 8546
Query: 2194 IQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRV----QNLRKDFTELQKTVK 2249
+ ++ E+ + Q + +L+ + +L D + +++V L+ E+ + +K
Sbjct: 8547 LMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK 8606
Query: 2250 EREK--DASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT 2286
E EK D SS Q+ L + +T GS+ PT
Sbjct: 8607 ELEKLLDVSSSQQDLSSWSSADEL------DTSGSVSPT 8639
Score = 34.3 bits (77), Expect = 3.5
Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 12/227 (5%)
Query: 585 NLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARL--- 641
+L ++ L EE +L+R E D+ ++ELQ++ + + +V+ + + L
Sbjct: 8400 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8459
Query: 642 ----YEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLN 697
+ K S++ ++ G+ + L+E L F + L+ L
Sbjct: 8460 EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE 8519
Query: 698 EKEEEELAYDWSDNNSNISAKRNYFSELTM---ELEEKQDVFRSLQDTAELLSLENHPAK 754
+ + D+N + +++ +L EL E Q SLQD + L L N
Sbjct: 8520 NIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL-LVNAEGT 8578
Query: 755 QTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESF 801
+EA V +K L V +H+KE S ++L S+
Sbjct: 8579 DCLEA-KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSW 8624
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
[Homo sapiens]
Length = 8797
Score = 354 bits (909), Expect = 1e-96
Identities = 725/4074 (17%), Positives = 1609/4074 (39%), Gaps = 457/4074 (11%)
Query: 1087 NALRIAEQEHTQEDLQ---QLRSDLDAVSMKCDSFLHQSP------SSSSVPTLRSELNL 1137
N++ E + ++DL Q L++ ++ D L ++ SS + R+ +
Sbjct: 1895 NSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQ 1954
Query: 1138 LVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDA--ELL--VKGYEIKLSQEEVVLADLSAL 1193
L +++ + L ++ + V+ ++ QD ELL ++ E + +E + AL
Sbjct: 1955 LCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQAL 2014
Query: 1194 EAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQ 1253
+ ++ L + KAK +A++ PE + ++ R L+
Sbjct: 2015 QQRLRVFNQLEDELNSHEHELCWLKD---KAKQIAQKDVAFAPEVDREINR-------LE 2064
Query: 1254 ERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEE---------TTAQQEMMKPG 1304
W + Q + + +++ +Y+ + K +E T QE +K
Sbjct: 2065 VTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWA 2124
Query: 1305 QAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKF-SQQYSTIVKDYELQLMTYKAFVES 1363
++ ++ +Q L + + L + +K S +S + D E + + E
Sbjct: 2125 FSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEK 2184
Query: 1364 QQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEE 1423
+++ + R LS D + ++ V +++ + + LR EE K E E
Sbjct: 2185 LEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRA-EELLKEFESE 2243
Query: 1424 KQEHVEKVKELLGWVSTLARNTQGKATSSE--------------TKESTDIEKAILEQ-- 1467
+ +++EL V+ L T+ T + KE T++ K L+
Sbjct: 2244 VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFT 2303
Query: 1468 ------QVLSEELTTKKEQVSEAIKT-------SQIFLAKHGHKLSEKEKKQIS---EQL 1511
+ ++TT +V E++ + K K + ++ IS E L
Sbjct: 2304 AQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENL 2363
Query: 1512 NALNKAYHDLCDGSANQLQ-------QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVG 1564
N+L + YH S + + SQL +T+ + + + +++ W
Sbjct: 2364 NSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFL 2423
Query: 1565 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQT-- 1622
A+ A RT D L+ DL+++ D + + + V +E QT
Sbjct: 2424 GAKAAAKESSDRTG--DSKVLEAKLHDLQNILDSVSDGQSKLDAVT-------QEGQTLY 2474
Query: 1623 -KLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKA------- 1674
LS + +++++E++ +A E+++A ++ ++ L++ + E + K
Sbjct: 2475 AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEM 2534
Query: 1675 -----AKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729
+ L E+K+ I + V V G+LL +++LS ++G L + +G+
Sbjct: 2535 EERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLS----QRGQLLSEEGH- 2589
Query: 1730 GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKL 1789
G Q + C + HQ LL + + +S Q L +H E + Q +
Sbjct: 2590 GAGQE----GRLCSQLLTSHQNLLRMTKEKL---RSCQVALQEH------EALEEALQSM 2636
Query: 1790 GELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPE 1849
+ LA +E+ L TL+ L + +QD
Sbjct: 2637 WFWVKAIQDRLACAESTLGSKDTLEKRLSQ-IQDIL------------------------ 2671
Query: 1850 TLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDA 1909
L+K +G ++ KG+ + +S KEG+ +++ +L+
Sbjct: 2672 ----LMKGEGEVKLNMAIGKGEQA-----------LRSSNKEGQR------VIQTQLETL 2710
Query: 1910 TERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGV 1969
E + + S S L ++ Q++ + + L+ WM++ + +E L PG
Sbjct: 2711 KEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP----QPG- 2765
Query: 1970 LQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSL 2029
L+E+ LQ L+E + L ++ E+ E D + + + F +
Sbjct: 2766 LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY-EKTEDESFKDTAQEELKTQFNDI 2824
Query: 2030 SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM 2089
E+ +++ + +++ + ++ L S S Q+ L+
Sbjct: 2825 MTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS--- 2881
Query: 2090 KLKQDIARQKSSLEATREMVTRFMETADSTTAA-------VLQGKLAEVSQRFEQLCLQQ 2142
K+K+ I ++ + + E +TTA+ +Q A+ Q + + Q
Sbjct: 2882 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2941
Query: 2143 QEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS---------GNQPDQDITHFFQQ 2193
E+ + ++ + F +L+Q +E S +L + G D++I + +
Sbjct: 2942 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3001
Query: 2194 IQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK 2253
QE+ ++ + + L+ + EL C F+ DL + +V L K++ L + +
Sbjct: 3002 GQEILDALQKAEPRTEDLKSQLNEL--CRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQ 3059
Query: 2254 DASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT-ETSMSAKELEKQIEHLKSLLDDWASK 2312
+ +Q FRK R FQ+WL + + + + E+ ++ ++ L + +
Sbjct: 3060 NKEQILQQ--RFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENG 3117
Query: 2313 GTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDM 2372
+ + KG L L+ + A Q K V ++ +H+
Sbjct: 3118 QHKLNMMLSKGELLSTLLTKEKAKGIQAK-------VTAAKEDWKNFHSN---------- 3160
Query: 2373 SDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL--KSMDAMSSP 2430
LH+++ +L+ + +M++ A + WL E+++ S P
Sbjct: 3161 -------------LHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLP 3207
Query: 2431 TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSR 2490
K + + + ++ L E+ P++ ++KE L + +++++ +L+S+
Sbjct: 3208 AK----RREQQKLQSVLEEIHCYEPQLNRLKEKAQQL---WEGQAASKSFRHRVSQLSSQ 3260
Query: 2491 WERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQK 2550
+ + +T + +L+ + F +L+ W+ + M+ + D ++L+++
Sbjct: 3261 YLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRT 3320
Query: 2551 QQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLN 2610
+++ +L + + Q + + + +L + T +Q++LQS+ W L
Sbjct: 3321 LKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT--IQQQLQSVKDMWASLLSAGI 3378
Query: 2611 SRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSD 2670
SQ++ A+ K T YQ+ ++ S + ++ L+ + E +L + + +
Sbjct: 3379 RCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN-------ESERQHAELRDKTTMLGK 3431
Query: 2671 LEQLDHEVKEAQTLCDELSVL---IGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQ 2727
+ L+ EV +L + + V + E Y+ + L+ + + +++ A + + + +
Sbjct: 3432 AKLLNEEVLSYSSLLETIEVKGAGMTEHYVT---QLELQDLQERYRAIQERAKEAVTKSE 3488
Query: 2728 AALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGS 2787
+ Q++Q+ WL +Q + + + ++ L++ +E Q +
Sbjct: 3489 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQAL 3548
Query: 2788 YEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQ 2847
++ E ++ S P E R L++ L+ W+ + ++ +++ + + K + +
Sbjct: 3549 LNSVLHTREDVIPSGIPQAEDRALES----LRQDWQAYQHRLSETRTQFNNVVNKLRLME 3604
Query: 2848 WHVEDLVPWIEDCKAKMS-ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADI 2906
+ + W++ + K+S R + E L + K EV R +E + + A
Sbjct: 3605 QKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQE 3664
Query: 2907 LINSSEADEDGIRDEKAGINQNMDAVTEE-------LQAKTGSLEEMTQRLREFQESFKN 2959
+++ S + + + + A+ + L+ + SLEE L + + + +
Sbjct: 3665 ILDESHVNSR-MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGS 3723
Query: 2960 IEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAP 3019
K + +++ D + K L+ L + ++ + R + V+
Sbjct: 3724 THKNFKNVATKIDKVDTV----MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLE 3779
Query: 3020 DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDE 3079
+G +A +L + ++ E+ V + +E L +F + + + +A+ +
Sbjct: 3780 EG-EAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEI 3838
Query: 3080 LDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE-EGTLDLLG--- 3135
L + + ++ + + L+K L+ + + E + + E+ E L+L+
Sbjct: 3839 L-------HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVT 3891
Query: 3136 LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND-ATTAAEEAEALQWV 3194
LK +++ L L GK LE + ED+ +L+ + + A +
Sbjct: 3892 LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLL 3951
Query: 3195 VGTEVEIINQQLADFKMFQKE------QVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE 3248
+ +E I QQLA K +E +++ LQMK + G +Q+ K L+
Sbjct: 3952 ETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQ 4011
Query: 3249 HDMEEINARWNTLNKKVAQRIAQ-LQEALLHCGKFQDALEPLLSWLADTE-ELIANQKPP 3306
+ +A +T AQR+ Q L+ L QD L+ +WL+ + +L + +PP
Sbjct: 4012 GTKDSYSAICST-----AQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPP 4066
Query: 3307 SAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESR 3366
+ + +K Q++ + LQ + + +D+L + D + + + + +
Sbjct: 4067 LSRAEAIK-QVKHFRALQ---EQARTYLDLL----------CSMCDLSNASVKTTAKDIQ 4112
Query: 3367 WTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI 3426
TE + +E LV A+ + E I S L +++ ++Q
Sbjct: 4113 QTE---------QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQ------QLQNMK 4157
Query: 3427 IRHKALEEDI-ENHATDVHQAVKIGQSLSSLTSPAEQGV--LSEKIDSLQAR-YSEIQDR 3482
RH LE +I +N + V VK QS + + + V L++K +S + + + + D+
Sbjct: 4158 RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQ 4217
Query: 3483 ---CCRKAALL----DQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQH 3535
CR++ L ++ L R + + V +L + + ++ D + +H +
Sbjct: 4218 WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEA 4277
Query: 3536 ADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKA 3595
LAL + RK ++ Q +++ ++ L++E+ ++ R+ + +
Sbjct: 4278 LKKLAL--ALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRK 4335
Query: 3596 LRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM 3655
++ + QS ++EL W E + +A + QSP + + E+
Sbjct: 4336 IQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELE 4395
Query: 3656 EHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS 3715
+++L ++ + + ++ + R+ + K +SDA +SD +GQR ++ A+
Sbjct: 4396 AKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEK 4455
Query: 3716 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFS 3775
Q+ A + + + +RK+M I L D + Q++ K+ + +++ + L++
Sbjct: 4456 TQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWA 4515
Query: 3776 HRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELS 3835
E+ E++K+ + K + L Y+++ S R LE+ V F E +++
Sbjct: 4516 QGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKAC 4575
Query: 3836 PWIEETRALIAQLPSPAIDHE--QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ-LKEL 3892
W+++ A I P + +E +L Q + + + E E++ + L + G L L
Sbjct: 4576 HWLKQ--ADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4633
Query: 3893 NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL 3952
N + + EK + I + + + EA+ E+ IE ++L L
Sbjct: 4634 NEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILAR---KEYASLIELTTQSLSEL 4690
Query: 3953 SSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIG-RSQGADKDL 4011
++ +P ++ + E +S L+++ EA+ ++ G RS G
Sbjct: 4691 EAQFLRMSKVPTDL-AVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ- 4748
Query: 4012 AAKEIQDKLDQMVFFWEDIKARAEEREIKFLD---VLELAEKFWYDMAALLTTIKDTQDI 4068
DK+ +V + +K + E+R D + EK + L ++K+ Q
Sbjct: 4749 -----PDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSK 4803
Query: 4069 VHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKS 4128
V++ P +++++ ++ L+ + I DL + R
Sbjct: 4804 VNEETLPA------EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQ 4857
Query: 4129 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDL 4188
I + L E + + E M ++ +Q + DWL +K PV DL
Sbjct: 4858 IQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRR--VKAELSGPVYLDL 4915
Query: 4189 NTVKDQLNEMKEFKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRDIIREPLTELK 4243
N ++D E++ K++++Q++++ M L+H+ + KA + D + L EL
Sbjct: 4916 N-LQDIQEEIR--KIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISAD-LEHSLAELS 4971
Query: 4244 HLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG---DPKV 4300
L ++ E + RQ L ++ + WL +ELL ++G D +
Sbjct: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQ----LAGNGLDVES 5027
Query: 4301 IEVELAKH----------HVLKNDVLAHQATVETVNK-AGNELLESSAGDDASSLRS-RL 4348
E L H H ++ + AT++ + K G E LE + LRS R+
Sbjct: 5028 AEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVA--SLELRSQRM 5085
Query: 4349 EAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPE 4408
+ +LQ+ + Q ++ ++ E L E + +++ S
Sbjct: 5086 SRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS---------H 5136
Query: 4409 TAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVV 4468
A E+L H L S + + E L +K + + +D+ S + +S+ + Q+W +
Sbjct: 5137 EAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDA-SKATLSRSMTTVWQRWTRL 5195
Query: 4469 SSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHK 4528
+ ++++ LE+A++ T F N +++ + + L +S +L+ +E H
Sbjct: 5196 RAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHD 5255
Query: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL-------------IKNLLVSVQSRWE 4575
F ++EL+Q + L L Q+ +L + + ++Q R
Sbjct: 5256 TF----------VLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCL 5305
Query: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL-DSELEISNDPDKIKLQLS 4634
+ ++ G+ + K + + W+++ + +L + +EI +++++ L+
Sbjct: 5306 NMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLT 5365
Query: 4635 KHKEFQKTLGGKQPVYDTTIRTGRALKEK-----TLLPED-SQKLDNFLGEVRDKWDTVC 4688
+ ++ + + KEK T+LP + S +L +++ + D +
Sbjct: 5366 EATNHRQNIE----------KMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIR-DQIQ 5414
Query: 4689 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 4748
K E + + S Q + L L K++ + D V+ KV
Sbjct: 5415 DKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK----------TDNVVQAKTDQKV 5464
Query: 4749 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQ 4808
+EL + L + ++ +E + + ++ +L+ + + ++ S+L Q
Sbjct: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQ 5524
Query: 4809 ALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 4868
A E + + + ++L+W+ +A + L + L+ H+ ++ E K +D
Sbjct: 5525 AASHLEEYNEMLELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLE--ESKEID- 5580
Query: 4869 NSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAEL 4928
+ AM E + + C + + + EE+ K Q L+ A ++
Sbjct: 5581 SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE 5640
Query: 4929 LEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 4982
L++L A ++ A+ TL + + +K ++ Q + EM +P V V
Sbjct: 5641 LKKLQAALEQAQATLTSPEVGRL-----SLKEQLSHRQHLLSEMESLKPKVQAV 5689
Score = 325 bits (834), Expect = 6e-88
Identities = 865/4930 (17%), Positives = 1893/4930 (38%), Gaps = 650/4930 (13%)
Query: 547 HLKAEPLTKATHSSSTSWFRKPM--TRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLE 604
HL +E K HSS S + M T + + +S +E R L W + + + E
Sbjct: 2151 HLLSE--LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDE 2208
Query: 605 RAEWGND---------------LPSVELQLETQQHIHTS---VEELGSSVKEARLYEGKM 646
W N+ L + EL E + + +EEL S V + + ++
Sbjct: 2209 IEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLK----EL 2264
Query: 647 SQNFHTS------YAETLGKLETQYCKLKETSSFRMRHLQS----LHKFVSRATAELIWL 696
++N T A+ + KLE ++ E + ++ + + KF++ T W
Sbjct: 2265 TKNLETPPDLQFIEADLMQKLEHAK-EITEVAKGTLKDFTAQSTQVEKFINDITT---WF 2320
Query: 697 NEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQT 756
+ EE + + + N + + K+ ++ EL+ +Q S Q+ L + H A+
Sbjct: 2321 TKVEESLM--NCAQNETCEALKK--VKDIQKELQSQQSNISSTQENLNSLCRKYHSAE-- 2374
Query: 757 VEAYSAAVQSQL---QWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKY 813
+E+ A+ + + + QLC + ++E+ F +E + + + + K
Sbjct: 2375 LESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK-HFSESMQEFQEWFLGAKAAAKE-- 2431
Query: 814 SCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTIS- 872
S D LE L D + + + +S + ++ +T+ H+ K +S
Sbjct: 2432 SSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYA-------HLSKQIVSS 2484
Query: 873 ----VKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKD 928
+ + Q + C D+ L+D + S G+ L ++
Sbjct: 2485 IQEQITKANEEFQAFLKQCLKDKQALQDCA--------SELGSFEDQHRKLNLWIHEMEE 2536
Query: 929 AIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLD-LVQTWNLEKLRSSAPGECH 987
+ +S Q + +++H L R+ LD L Q L G+
Sbjct: 2537 RFN-TENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEG 2595
Query: 988 QIMKNLQAHYEDFLQDSRD---SVLFSVADRLRLEEEVEAC----KARFQHLMKSMENED 1040
++ L +++ L+ +++ S ++ + LEE +++ KA L +
Sbjct: 2596 RLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLG 2655
Query: 1041 KEETVAKMYISELKNIRLRLEEYEQRVVKRI----QSLASSRTD------------RDAW 1084
++T+ K +S++++I L E E ++ I Q+L SS + ++ W
Sbjct: 2656 SKDTLEKR-LSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVW 2714
Query: 1085 QDNALRIAEQEHTQEDL-----------QQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRS 1133
D + T E + QL +++V K + L P L
Sbjct: 2715 ADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLD 2774
Query: 1134 EL-NLLVEKMDHVYGLSTVYLNKL----KTVDVIVRSIQDAELLVKGYEIKL-------S 1181
L ++L E DH L + KT D + EL + +I
Sbjct: 2775 HLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRK 2834
Query: 1182 QEEVVLADLSALEA-----HW-----STLRHWLSDVKDKNSV----FSVLDEEIAKAKVV 1227
EE+V L L+A W L W SD+ +S S + E I ++
Sbjct: 2835 VEEIVKDHLMYLDAVHEFTDWLHSAKEELHRW-SDMSGDSSATQKKLSKIKELIDSREIG 2893
Query: 1228 AEQMSR---LTPE-------------------RNLDLERYQEKGSQLQERWHRVIAQLEI 1265
A ++SR L PE D +++++ Q Q +++Q+ +
Sbjct: 2894 ASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMAL 2953
Query: 1266 RQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFA- 1324
+ E L L+K T AQQ + G+ D ++ Q L A
Sbjct: 2954 SEQEFSGQVAQLEQALEQFSALLK----TWAQQLTLLEGKNTDEEIVECWHKGQEILDAL 3009
Query: 1325 -----EIERNQTKLDQCQKFSQQYST-------IVKDYELQLMTYKAFVESQQKSPGKRR 1372
E +++L++ +FS+ ST ++K+Y + +A Q K ++
Sbjct: 3010 QKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNC--LCLQASKGCQNKEQILQQ 3067
Query: 1373 RMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEE--EEKVVEEEKQEHVEK 1430
R + Q ++ + TA Q++ +S +L++++E E + K +
Sbjct: 3068 RFRKAFRDFQQWLVNAKIT-TAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLS 3126
Query: 1431 VKELLGWVSTL--ARNTQGKATSSETKEST------DIEKAILEQQVLSEELTTKKEQVS 1482
ELL + T A+ Q K T+++ E A+ ++ ++ E +
Sbjct: 3127 KGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQ 3186
Query: 1483 EAIKTSQIFLAKHGHKL-------SEKEKKQ--------ISEQLNALNKAYHDLCDGSA- 1526
+ + ++ + + ++L E++K Q QLN L + L +G A
Sbjct: 3187 DWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAA 3246
Query: 1527 -----NQLQQLQSQ---LAHQTEQKT-----LQKQQNTCHQQLEDLCSWVGQAERALAGH 1573
+++ QL SQ L++ T++K + + N +++L W+ A L +
Sbjct: 3247 SKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY 3306
Query: 1574 QGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALR 1633
T+ D S L L+ L Q + +V E ++ SP + ++
Sbjct: 3307 CHPTS--DKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNT----SPEGIPTIQ 3360
Query: 1634 EKLHQAKEQYEALQEETRVAQKELEEAVTS-------ALQQETEKSKAAKELAENKKKID 1686
++L K+ + +L + +LE A++ Q L E++++
Sbjct: 3361 QQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHA 3420
Query: 1687 ALLDWVTSVGSS---GGQLLTNLPGME--QLSGASLEKGAL------DTTDGYMGVNQAP 1735
L D T +G + ++L+ +E ++ GA + + + D + Y + +
Sbjct: 3421 ELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERA 3480
Query: 1736 EKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ--------HGHNLTPEEQQMLQQ 1787
++ + E + HQE + F + Q LDQ H H T + Q LQ
Sbjct: 3481 KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQV 3540
Query: 1788 KLGELKEQYSTSLAQSE---------AELKQVQTLQDELQKFL----------------- 1821
E + ++ L E AE + +++L+ + Q +
Sbjct: 3541 HCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKL 3600
Query: 1822 ----QDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTI 1877
Q ++ + WL+ +E+++ + S+ T L + + E+V +++ ++ V
Sbjct: 3601 RLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGA 3660
Query: 1878 SGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQF 1937
Q++LD S + + + + T RY AL + L + +
Sbjct: 3661 RAQEILD----------ESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEES 3710
Query: 1938 QNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAE-HQVPVEKLQK 1996
++S S W + N + + + D ++ ++L T + L +++ + H + +K
Sbjct: 3711 ESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREK 3770
Query: 1997 VARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLES 2056
R + +E A +++ + + L+ ++ + L+K + ++ + ++
Sbjct: 3771 GERAVKYLEEGEA---ERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKA 3827
Query: 2057 LLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETA 2116
L Q I E ++ L + + + L+ L+Q + + S+++ RE +E
Sbjct: 3828 LTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV 3887
Query: 2117 DSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKS-R 2175
T L+ K+ ++ ++ LC +E SL+ + E + ++++++ S R
Sbjct: 3888 QDVT---LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGR 3944
Query: 2176 MLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLV----TELSSCGFALDLCQHQ 2231
++A + QQ+ ME+ D L +L T + C L Q
Sbjct: 3945 LVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQ 4004
Query: 2232 D---RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT-E 2287
+ +Q + ++ + T + + ++ + ++ Q WL + + P+ +
Sbjct: 4005 NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 4064
Query: 2288 TSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILP 2347
+S E KQ++H ++L + + ++ C L N ++ TA D Q +I
Sbjct: 4065 PPLSRAEAIKQVKHFRALQE----QARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQ 4120
Query: 2348 SVGSSVGSVNGYHTCKDL-TEIQCDMSD----------------VNLKYEKLGGV----- 2385
+ + G+ K L +E+ + D +N+ + V
Sbjct: 4121 KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVK 4180
Query: 2386 -LHERQESLQAILNRMEEV--------HKEANSVL-QWLE-----------SKEEVLKSM 2424
L +Q S+ I+ ++ ++ HKE N + QWL+ +E++ ++
Sbjct: 4181 KLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTR 4240
Query: 2425 DAMSSPTKTET------------VKAQAESNKAFLAELEQNSPKIQKVKEALAGL----- 2467
D E ++ AES L L++ + +Q+ K A+ L
Sbjct: 4241 DYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ 4300
Query: 2468 -LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL 2526
++ + N + E K+ L RW + ++ + + + L Q+ +L W
Sbjct: 4301 KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWA 4360
Query: 2527 MEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSL 2586
E++ + S P+M + E EA++ + L + A ++ D+ L
Sbjct: 4361 EEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMA---DLGL 4417
Query: 2587 STSQVQKELQSINQKWVE-LTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLS 2645
+ QV ++ S Q V L+D + R +++A+ + TQ+ + + +++ +++
Sbjct: 4418 NERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIM 4477
Query: 2646 VQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRL 2705
+ I P+ V +Q++ ++ L+ +EV EL + EQ K E+ +L
Sbjct: 4478 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQE-KSEVLGKL 4536
Query: 2706 ETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLE 2765
+ + + + R+ L+ L S + F++ FD+ WL + +
Sbjct: 4537 QELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESS 4596
Query: 2766 RLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEEL 2825
L +QL + + + ++ + G+++L S+ + L +L L + +
Sbjct: 4597 ELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSY-LSEKLNALPRQFNVI 4655
Query: 2826 SKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-- 2883
D+ ++++ + ++Y +E + + +A+ + + +E +L
Sbjct: 4656 VALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDG 4715
Query: 2884 -KAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS 2942
+A+L+EV ++ LN + ++ + + + + TE+ +
Sbjct: 4716 CRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQ---RVSL 4772
Query: 2943 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL----EKLRAQQEVLQ 2998
LE+ T +E ++ + +E++++ K + Q+ N+ EKL+ +
Sbjct: 4773 LEDTTSAYQEHEKMCQQLERQLKSVKEE---------QSKVNEETLPAEEKLKMYHSLAG 4823
Query: 2999 ALEPQVDYLRNFTQGLVEDAP--DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKL 3056
+L+ L+ T L + AP D + HQ + Q E + + E+++
Sbjct: 4824 SLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRM 4883
Query: 3057 EGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEA 3116
F + L + EL G + + +Q +I +++ ++ + A
Sbjct: 4884 VQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNA 4943
Query: 3117 SEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLK 3176
+ + + L L+ L L++ G + E + RQ L + + +Y+ +
Sbjct: 4944 LSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQ 5003
Query: 3177 GLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLG---QG 3233
ND A+E L G +VE + L F + D L++++ L
Sbjct: 5004 AANDWLEDAQELLQLAGN-GLDVESAEENLKSHMEFFSTE-DQFHSNLEELHSLVATLDP 5061
Query: 3234 LIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWL 3293
LI+ GK+ LE + + R +++ ++ LQ +Q A E ++ +
Sbjct: 5062 LIKPTGKE----DLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELM 5117
Query: 3294 ADTEELIAN-QKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELAD 3352
DTE+ ++ ++ + ++ E K L +++ + L+ + ++ ++ A
Sbjct: 5118 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDAS 5177
Query: 3353 REKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANS 3412
+ ++ + ++ RWT L + A ++K LED + F+ + ++ + + KL S
Sbjct: 5178 KATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGS 5237
Query: 3413 EPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLT-----SPAEQGVLSE 3467
A++ + H ++E + + + Q+LS L +P E+ L +
Sbjct: 5238 SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ--QTLSMLQDGAAPTPGEEPPLMQ 5295
Query: 3468 KIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFK 3527
+I ++Q R +Q++ L+ Q L + + V W+ E ++ L + ++
Sbjct: 5296 EITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIE--- 5352
Query: 3528 QDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYAD 3587
+ Q + L E N ++N++ K + ++ G +L E + + A+
Sbjct: 5353 ---IDAQLEELQILLTEATNHRQNIE---KMAEEQKEKYLGLYTILPSE----LSLQLAE 5402
Query: 3588 ITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQ-SPTGEQIPQFQQR 3646
+ + K ++ + + ++T +EL+ ++++ ++L T + + + Q +
Sbjct: 5403 VAL-DLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5461
Query: 3647 QKELKKEVMEHRLVLDTVN----EVSRALLELVPWRAREG--LDKLVSDANEQYKLVSDT 3700
QK L +E LD N E+ A+ + + + G L K + E ++
Sbjct: 5462 QKVLGEE-------LDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQ 5514
Query: 3701 IGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPI------RLEQDQTTAQLQ 3754
R+ +++ A ++Y + + L W+ K K++A G I +L + Q
Sbjct: 5515 AENRLSKLNQAASHLEEYNEMLELILKWIE--KAKVLAHGTIAWNSASQLREQYILHQTL 5572
Query: 3755 VQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERY 3814
++++ ID ++M E + + ++ C E+ + ++ L ++ E + + R
Sbjct: 5573 LEESKEID--SELEAMTEKLQYLTSVY--CTEK----MSQQVAELGRETEELRQMIKIRL 5624
Query: 3815 ARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAE 3874
L+ A + +F ++L +E+ +A L SP + L++Q + L +
Sbjct: 5625 QNLQDAAKDMKKFEAELKKLQAALEQAQAT---LTSPEVGRLSLKEQLSHRQHLLSEMES 5681
Query: 3875 HKPHIDKLLKIGPQLKELNPEEGEM-VEEKYQKAENMYAQIKEEVRQRALALDEAVSQST 3933
KP + + L+ + + + + ++++ Q+ + AV Q
Sbjct: 5682 LKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYE 5741
Query: 3934 QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEAL 3993
Q + +++ + + +E + P+ + + +++ IS ++ +++ Q +L
Sbjct: 5742 Q---YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASL 5798
Query: 3994 KRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWY 4053
+ + L +++ A L E++ + ED+ V+ + +
Sbjct: 5799 NSKCKMLTMKAKHATMLLTVTEVEGLAEGT----EDLDGELLPTPSAHPSVVMMTAGRCH 5854
Query: 4054 DMAALLTTIKDTQDIVHDLESP--------------GIDPSIIKQQVEAAETIKEETDGL 4099
+ + +T + ++ SP ++ I Q +AE ++ + +
Sbjct: 5855 TLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKI 5914
Query: 4100 HEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQ 4159
H + + G +P + ++ +WE L E+ L +A++ +
Sbjct: 5915 HPSTS-----ASQEFYEPGL--EPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQK 5967
Query: 4160 YQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQ- 4218
YQD+LQ++ ++ +KL P G + + Q+ E + E+ Q E+ +L
Sbjct: 5968 YQDSLQSISTKMEAIELKLSESPEPG---RSPESQMAEHQALMDEILMLQDEINELQSSL 6024
Query: 4219 GELMLKKA--TDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGAL----------LA 4266
E ++ ++ D ++ ++ LT L + K + ++ LE L A
Sbjct: 6025 AEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQA 6084
Query: 4267 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326
L +++ +EL SWL T+ LD +P +E +L +N ++ + V ++
Sbjct: 6085 LQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMD---CQNMLVEIEQKVVALS 6141
Query: 4327 KAG----NELLESSA--GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFH 4380
+ N LLE A D+A L +L + + + +++ +Q T Q+ +
Sbjct: 6142 ELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKE--E 6199
Query: 4381 SEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRL 4440
S+++ + ++ L+ ++ T + + L EL +L ++ + +G
Sbjct: 6200 SDVDLTATQSPGVQEWLAQARTT--WTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEE 6257
Query: 4441 MLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWL 4500
+L+ + + + +L Q+ ME KS E+ + + ++++ QEF
Sbjct: 6258 ILIQHSAAETSGDAGEKPDVLSQE-----LGMEGEKSSAEDQMRM--KWESLHQEF---- 6306
Query: 4501 TLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQL-KFLSQKQD 4559
S +L VL Q +E +++ ++++ +G L K QD
Sbjct: 6307 ----------STKQKLLQNVLEQEQEQVLYSRP-----NRLL----SGVPLYKGDVPTQD 6347
Query: 4560 VVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSE 4619
+ +LL + +E+V S + G + + ++ ++ WL+D E L
Sbjct: 6348 KSAVTSLLDGLNQAFEEV---SSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVA 6404
Query: 4620 LEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTL----LPEDSQKLD- 4674
+ P++ + L + K + D K K L PE+ D
Sbjct: 6405 TALL--PEETETCLFNQEILAKDIKEMSEEMD---------KNKNLFSQAFPENGDNRDV 6453
Query: 4675 ------NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAE 4728
LG + V + + + +L++ L F +L D Y + +LA
Sbjct: 6454 IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLAN 6513
Query: 4729 --DQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQ 4786
+QPV ++ + D K F G +++ +R + +E +L
Sbjct: 6514 VFEQPVAEQIEAIQQAEDGLKEFD------AGIIELKRRGDKLQVEQPS------MQELS 6561
Query: 4787 ELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTE 4845
+L +D + + S++S L Q L + + L + L ++ + + + E
Sbjct: 6562 KLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE 6621
Query: 4846 ALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVL 4905
+Q L+D HKE+ + +E + + F +++
Sbjct: 6622 EIQQLLDKHKEYFQGLESHMI-----------------------------LTETLFRKII 6652
Query: 4906 TWAKQHQQRLETAL----SELVANAELLEELLAWI--QWAETTLIQRDQEPIPQNIDRVK 4959
++A Q + + T L S ++ A L +I W+ + DQ+ + + ++ V+
Sbjct: 6653 SFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSH---LDEDQQELSRQLEVVE 6709
Query: 4960 ALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMP 5019
+ I E R +DR+T K+ + P + + G++ L
Sbjct: 6710 SSIPSVGLVEENEDRL---IDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLIS------- 6759
Query: 5020 ILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE-LKEFANFDFDVWRKKYM 5078
+S S+ ++ ++NQL W L K++ L RLE LK + + + +
Sbjct: 6760 -ISCSDLES-QLNQLGECW-------LSNTNKMSKELHRLETILKHWTRYQSE--SADLI 6808
Query: 5079 RWMNHKKSRV 5088
W+ K R+
Sbjct: 6809 HWLQSAKDRL 6818
Score = 318 bits (815), Expect = 9e-86
Identities = 822/4346 (18%), Positives = 1674/4346 (38%), Gaps = 589/4346 (13%)
Query: 1019 EEEVEACKARFQHLMKSMENEDKEETVAKM------YISELKNIRLRLEEYEQRVVKRIQ 1072
+ EV A+ + LMK + ++K E + K+ Y S L+ RL+E E+ +V R
Sbjct: 4507 QNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR-- 4564
Query: 1073 SLASSRTDRDA---WQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSV- 1128
+ D D W A + E +L S+L K + L QSP ++
Sbjct: 4565 --KHFKEDFDKACHWLKQADIVTFPEI---NLMNESSELHTQLAKYQNILEQSPEYENLL 4619
Query: 1129 -------PTLRSELNLLVEKMDHVYGLSTVYLNKL-KTVDVIVR-------SIQDAELLV 1173
T+ LN ++DH Y + LN L + +VIV +Q+A L
Sbjct: 4620 LTLQRTGQTILPSLN----EVDHSY--LSEKLNALPRQFNVIVALAKDKFYKVQEAILAR 4673
Query: 1174 KGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVF------SVLDEEIAKAKVV 1227
K Y S E+ LS LEA + + +D+ + ++ ++LDE + V
Sbjct: 4674 KEYA---SLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAV 4730
Query: 1228 AEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTL 1287
E + R+ +K L +HR+ Q E R S LE ++ L
Sbjct: 4731 DELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL 4790
Query: 1288 IKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIV 1347
+ ++ +Q + E++ E+L +L ++ + L + + +
Sbjct: 4791 ERQLKSVKEEQSKVN----EETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAP-- 4844
Query: 1348 KDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYIS 1407
L + Y+ Q G+ + + S AI + + +R + T+ + +
Sbjct: 4845 ---HLDPLAYEKARHQIQSWQGELKLLTS---AIGETVTECESRMVQSIDFQTEMSRSL- 4897
Query: 1408 DALRRLEEE-----------EKVVEEEK--QEHVEKVKELLGWVSTLARNTQGKATSSET 1454
D LRR++ E + + EE + Q H E+V+ L ++ L+ + K T ++
Sbjct: 4898 DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKE 4957
Query: 1455 KESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNAL 1514
S D+E ++ E L + + EA++T Q L E ++ +
Sbjct: 4958 LISADLEHSLAELSELDGD-------IQEALRTRQATLT---------EIYSQCQRYYQV 5001
Query: 1515 NKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQ------QNTCHQQLEDLCSWVGQAER 1568
+A +D + + LQ + L ++ ++ L+ ++ H LE+L S V +
Sbjct: 5002 FQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDP 5061
Query: 1569 ALAGHQGRTTQQDLSALQ-KNQSDLKD--LQDDIQNRATS----FATVVKDIEGFMEENQ 1621
+ +Q +++L+ ++Q +D Q D+ R T+ + +++ M + +
Sbjct: 5062 LIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTE 5121
Query: 1622 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 1681
KLS L K + E E L E +A+ S + EK A +E A
Sbjct: 5122 KKLSEFSLL----KTSSSHEAEEKLSEH---------KALVSVVNSFHEKIVALEEKASQ 5168
Query: 1682 KKKI--DALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLD 1739
+K DA ++ ++ Q T L + Q LE + T V +A E +D
Sbjct: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
Query: 1740 KQCEMM---------KARHQELLSQQQNFILATQSAQAFLD----------QHGHNLTPE 1780
+ + + KA LL F+L + Q+ L Q G TP
Sbjct: 5229 QLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPG 5288
Query: 1781 EQQMLQQKLG-------ELKEQYSTSLAQSEAELKQ---VQTLQDELQKFLQDHKEF--- 1827
E+ L Q++ ++E+ T+ + ELK V+T + ++ ++Q+ KE+
Sbjct: 5289 EEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN 5348
Query: 1828 ------------ESWLERSEKELENMHKGGSSPET--------LPSLLKRQGSFSEDVIS 1867
+ L + +N+ K + LPS L Q +E +
Sbjct: 5349 PTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQ--LAEVAL- 5405
Query: 1868 HKGDLRFVTISGQKVLDMENSFKEGKEPS-EIGNLVKD------KLKDATERYTALHSKC 1920
DL+ K+ ++E S +E S +I L KD KLK T+ +
Sbjct: 5406 ---DLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQ 5462
Query: 1921 TRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL 1980
LG L D + + +A V+K L + ++ T+
Sbjct: 5463 KVLGEEL--------------DGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELH 5508
Query: 1981 QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSH----FQSLSYSLAER 2036
Q+ + + + + KL + A + E + +++ +L+H + S S L E+
Sbjct: 5509 QQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA--KVLAHGTIAWNSAS-QLREQ 5565
Query: 2037 SSLLQKAIAQSQSVQESLESLLQSIGEVEQ----NLEGKQVSSLSSGV--IQEALATNMK 2090
L Q + +S+ + LE++ + + + +QV+ L +++ + ++
Sbjct: 5566 YILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQ 5625
Query: 2091 LKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLK 2150
QD A+ EA + + +E A +T + G+L+ ++ +Q S ++
Sbjct: 5626 NLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS-----LKEQLSHRQHLLSEME 5680
Query: 2151 KLLPQAEMFEHLSGKLQ----------------QFMENKSRM--------------LASG 2180
L P+ + + L+ + E SR+ +
Sbjct: 5681 SLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY 5740
Query: 2181 NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2240
Q +Q++ H Q I+ + E+ED+ ++ L ++S +H++ Q +
Sbjct: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS---------RHEELAQKI--- 5788
Query: 2241 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2300
K +E+ +S + L K T + E EG TE + + L
Sbjct: 5789 -----KGYQEQIASLNSKCKMLTMKAKHA-TMLLTVTEVEGLAEGTE-DLDGELLPTPSA 5841
Query: 2301 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2360
H ++ TL+ + + + E EI++P + ++ S + + +SV Y+
Sbjct: 5842 HPSVVMMTAGRCHTLLSPVT-EESGEEGTNSEISSPPAC-RSPSPVANTDASVNQDIAYY 5899
Query: 2361 TCKDLTEIQCD--------------------------MSDVNLKYEKLGGVLHERQESLQ 2394
+Q D + D+ +E L V+ E+Q +L
Sbjct: 5900 QALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLY 5959
Query: 2395 AILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNS 2454
L R ++ S+ +E+ E L SP + ++Q ++A + E+
Sbjct: 5960 EALERQQKYQDSLQSISTKMEAIELKLSE-----SPEPGRSPESQMAEHQALMDEILMLQ 6014
Query: 2455 PKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR----------- 2503
+I +++ +LA LV+ + +Q L ER + + +
Sbjct: 6015 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6074
Query: 2504 QLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFE 2561
QLEE A ++ +L WL+ + + +P + AQ Q ML E E
Sbjct: 6075 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIE 6134
Query: 2562 ARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAI 2620
+ +L+ + +L G Q+ +L+ + +EL L+ + Q
Sbjct: 6135 QKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDK-----QLN 6189
Query: 2621 VKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKE 2680
++ T ++ D+ Q VQ ++ QQ + + + + +LEQ E+ E
Sbjct: 6190 MQGTAQEKEESDVD---LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQ---ELAE 6243
Query: 2681 AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMF 2740
++L ++ GE+ L ++ A G A ++ + L L +
Sbjct: 6244 QKSLLRSVASR-GEEIL-------IQHSAAETSGD---AGEKPDVLSQELGMEGEKSSAE 6292
Query: 2741 DELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLL 2800
D++R + + S K + LQ+ L++ +E +V+ + LL
Sbjct: 6293 DQMRMKWESLHQE------FSTKQKLLQNVLEQEQE------------QVLYSRPNRLLS 6334
Query: 2801 SVP------PGEEKRTLQNQLVELKNHWEELSKKT--ADRQSRLKDCMQKAQKYQWHVED 2852
VP P ++K + + L L +EE+S ++ A RQS + QK V
Sbjct: 6335 GVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS-----IHLEQKLYDGVSA 6389
Query: 2853 LVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSE 2912
W++D + ++ + L P + E+ L + + ++++ ++ + +
Sbjct: 6390 TSTWLDDVEERLF-VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENG 6448
Query: 2913 ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLE 2972
+ D I D + + + + + ++E Q++ FQ K + + K+ +
Sbjct: 6449 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII- 6507
Query: 2973 IFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAE 3032
Q +N + + Q E +Q E D L+ F G++E G L +
Sbjct: 6508 ------LQKLANVFEQPVAEQIEAIQQAE---DGLKEFDAGIIELKRRGDK----LQVEQ 6554
Query: 3033 VAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELD-GMGAIGRDTD 3091
+ QE +++ + +++ ++ G+ Q + L DL D L+ G + D
Sbjct: 6555 PSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQK 6614
Query: 3092 SLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLL---GLKRELE---ALNK 3145
+ S E+++ L+K +E+ HM+ E + +++E + L
Sbjct: 6615 IIVSSKEEIQQLLDKHKEYFQGLES------HMILTETLFRKIISFAVQKETQFHTELMA 6668
Query: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
Q + +R R +LE L E + + + + E E+ VG E ++
Sbjct: 6669 QASAVLKRAHKRGVELEYIL---ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRL 6725
Query: 3206 LADFKMFQ--KEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNK 3263
+ ++Q K ++ Q KL QV G+ L+ S LE + ++ W +
Sbjct: 6726 IDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTN 6781
Query: 3264 KVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVVKAQIQE 3319
K+++ + +L+ L H ++Q L+ WL ++ + S E ++V+ +
Sbjct: 6782 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNA 6841
Query: 3320 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379
+ +D + + + + G ++ + ++ D + +L ++S+WT+LL+ A Q+
Sbjct: 6842 FLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-DTATLRSELSRIDSQWTDLLTNIPAVQE 6900
Query: 3380 QLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP-----VGTQTAKIQQQIIRHKALEE 3434
+L + + + ++S+ E + E +G + I + + ++K +
Sbjct: 6901 KLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQKYKGFKI 6958
Query: 3435 DIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID------SLQARYSEIQDRCCRKAA 3488
DI V + QS+ ++S + S+K D ++ + +Q K
Sbjct: 6959 DINCKQLTVDF---VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 7015
Query: 3489 LLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNR 3548
LL+ L + + E+ V+ L E ++K + Q + D L + I +
Sbjct: 7016 LLEGLLESWSEY-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAK 7074
Query: 3549 KKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK 3608
+K V++ +NG AL++ + ++ L + +A++ + L+ +
Sbjct: 7075 EKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSS 7134
Query: 3609 FQSTYEELTGWLREVEEELAT----SGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV 3664
+ ++++ +L E L+ +G Q+ Q Q +L+K+ L
Sbjct: 7135 HKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKF 7190
Query: 3665 NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----Q 3720
++ LL+ E L + + N ++ + + I +++ A +Q Q+Y+ Q
Sbjct: 7191 GSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQ 7250
Query: 3721 AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 3780
A T L A + D+ +Q + KDS+ L ++
Sbjct: 7251 CASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQL 7310
Query: 3781 FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE 3840
+ +Q SL Q A+ ++ L+ + F ++ E L WI E
Sbjct: 7311 KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVE 7370
Query: 3841 TRALI-AQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM 3899
++ Q PS + D ++++ EE++ + P +D+L ++G +L LN +E
Sbjct: 7371 AEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP-LNDKE--- 7426
Query: 3900 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 3959
++ Q ++ I + +R L + Q F +K E +E L +L +
Sbjct: 7427 -IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQT---FLEKCETWMEFLVQTEQKLAVE 7482
Query: 3960 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4019
I + E ++ E+ Q ++ G+ L+ + Q D+D E K
Sbjct: 7483 --ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD----EFNLK 7536
Query: 4020 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4079
L + W+ + RA++R +++ + W + ++ V L G+
Sbjct: 7537 LTLLSNQWQGVIRRAQQRR----GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7592
Query: 4080 SIIKQQVEAAETIKEETDGLHEELEFIRILGA---------DLIFACGETEKPEVRKSID 4130
I Q A T+ +E +E F+R G+ L+ + + ++ +
Sbjct: 7593 VPIPLQ--QARTLFDEVQ--FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELA 7648
Query: 4131 EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNT 4190
E+ W++ + +E+ +KL ++ ++ + + D L+ L T
Sbjct: 7649 EIQEKWKSASMRLEEQKKKLAFLLK---DWEKCEKGIADSLEK--------------LRT 7691
Query: 4191 VKDQLNE-MKEFKVEVYQQQIEMEKLNHQ--------GELMLKKAT-----DETDRDIIR 4236
K +L++ + + E++ +Q+ ++L + +L L K T D I+
Sbjct: 7692 FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN 7751
Query: 4237 EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG 4296
E + L+ WE L +++ R+ ++ L F +EL WLT E + +G
Sbjct: 7752 ERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ----NG 7807
Query: 4297 DPKVIE-VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW 4355
D + E +E K + +A + ++ + + G L ++S AS + +L +N W
Sbjct: 7808 DILIEEMIEKLKKDYQEEIAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
Query: 4356 ESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT---GGLPETARE 4412
+ +L R ++L+ TL Q + L +ES+L+ KP E +
Sbjct: 7867 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQR 7924
Query: 4413 QLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE---QSVALLEQKWHVVS 4469
+L+ EL ++ +L+ ++L D + ++ + Q+ L+++W +
Sbjct: 7925 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7984
Query: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV 4529
+ ER+ K+EE L +F + F +WL +E++ S +I ++++ +
Sbjct: 7985 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
Query: 4530 FANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLD 4589
F +V+ Q+ +++ +L ++ +K ++ RW+ + +R R L
Sbjct: 8045 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8104
Query: 4590 DARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPV 4649
+ ++F A ++ WL + + L + +E ++ D ++ ++ + K FQ+ +
Sbjct: 8105 HFIGQREEFETARDSILVWLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNK 8162
Query: 4650 YDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFM 4709
+ I G L EK+ P D+ ++ L E+R V G+ VER HK L
Sbjct: 8163 IEQIIAQGEQLIEKS-EPLDAAIIEEELDELRRYCQEVFGR-VERYHKKLIRLPLPDDEH 8220
Query: 4710 DALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLK--RSG 4767
D ++ ED DL D+ Q Q L+ RSG
Sbjct: 8221 DLSDRELE---------LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSG 8271
Query: 4768 RELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWL 4827
R+ + + WD LS +S + +AL + E
Sbjct: 8272 RD-----------TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE---------EGQ 8311
Query: 4828 SEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVIL---AVCHP 4884
+ + LR L D AL+S I ++ K +++ R + E I+ P
Sbjct: 8312 DDKDFYLRGAVGLSGDHSALESQI---RQLGKALDDSRFQIQQT----ENIIRSKTPTGP 8364
Query: 4885 DCITTIKHWITIIR---------ARFEEVLTWAKQHQQRL---------ETALSELVANA 4926
+ T+ K ++ ++ R E L K+ ++ L ET + ++
Sbjct: 8365 ELDTSYKGYMKLLGECSSSIDSVKRLEHKL---KEEEESLPGFVNLHSTETQTAGVIDRW 8421
Query: 4927 ELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTY 4986
ELL+ + +Q+ Q+ +++ + A + + + +E++ R + D T
Sbjct: 8422 ELLQAQALSKELRMKQNLQKWQQ-FNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8480
Query: 4987 KRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAK-----NPRINQLSARWQQV 5041
+ K ++ + RK++ P +Q+++K R++Q++ RW +V
Sbjct: 8481 QIKKLKEL------QKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRV 8534
Query: 5042 WLLALERQRKLNDALDRLEELKEFAN 5067
L E + L DAL + + E ++
Sbjct: 8535 CSLLEEWRGLLQDALMQCQGFHEMSH 8560
Score = 293 bits (749), Expect = 4e-78
Identities = 761/4237 (17%), Positives = 1608/4237 (37%), Gaps = 493/4237 (11%)
Query: 929 AIEMASRVEQSYQKVMALWHQLHVNTKSLIS--------WNYLRKDLDLVQTW--NLEKL 978
++E A V + + A W L V +S+ S W+ + +Q W + EK+
Sbjct: 576 SVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKM 635
Query: 979 RSSAPGECHQIMKNLQAHYEDFL-QDSRDSVLFSVADRL---RLEEEVEACKARFQHLMK 1034
+ + +NL + + + L D + L++++ R++ L
Sbjct: 636 LNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFM 695
Query: 1035 S---------MENEDKEETVAKMYISEL-----KNIRLRLEEYEQRVVKRIQSLASSRTD 1080
M+ KE T + +S K + LE V IQ L
Sbjct: 696 EVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQR 755
Query: 1081 RDAWQDNALRIAEQEH--TQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLL 1138
I + H T+E Q+ ++ A K L + S P L LL
Sbjct: 756 VPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS-PLLYESQQLL 814
Query: 1139 VEKMDHVYGLSTVY--LNKL-KTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEA 1195
+ + +++ Y L K+ + + V+ R Q + L + ++ L+ +E L+ +E
Sbjct: 815 IPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEK 874
Query: 1196 HWSTLRHW--LSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQ 1253
+++ + LS+V K+ + L +IA V + M + T D +++ E S+L
Sbjct: 875 GSQSVQKFVTLSNVL-KHFDQTRLQRQIADIHVAFQSMVKKTG----DWKKHVETNSRLM 929
Query: 1254 ERWHRVIAQLE----IRQSELESI---QEVLG---------DYRACHGTLIKWIEETTAQ 1297
+++ A+LE I Q LE +E+L D R + L E T
Sbjct: 930 KKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDIL 989
Query: 1298 QEMMKPGQAEDSRVLSEQLS-----------------QQTALFAEIERNQTKLDQCQKFS 1340
E + G E R L +Q ++ A +E +T+LD+ K
Sbjct: 990 PEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLM 1049
Query: 1341 QQYST--IVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMD--LRTRYTALV 1396
Q + I+K++ + F + ++R L + D T T V
Sbjct: 1050 PQEGSEKIIKEHRV------FFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHV 1103
Query: 1397 TLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQG-KATSSETK 1455
TL S + +E+ +K +++ + E W+ST +G K + +T
Sbjct: 1104 TLKELRAAIDSTYRKLMEDPDKW-----KDYTSRFSEFSSWISTNETQLKGIKGEAIDTA 1158
Query: 1456 ESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALN 1515
++++A+ E + TK+ + +K+ L + SE E ++ ++L L+
Sbjct: 1159 NHGEVKRAVEEIR----NGVTKRGETLSWLKSRLKVLTEVS---SENEAQKQGDELAKLS 1211
Query: 1516 KAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQG 1575
++ L ++++++ S + K + K N+ + + QAE+ L
Sbjct: 1212 SSFKALVT-LLSEVEKMLSNFGDCVQYKEIVK--NSLEELISGSKEVQEQAEKILDTENL 1268
Query: 1576 RTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREK 1635
QQ L Q+ + + D+Q + A + G + +L R+L + +
Sbjct: 1269 FEAQQLLLHHQQKTKRISAKKRDVQQQ---IAQAQQGEGGLPDRGHEEL--RKLESTLDG 1323
Query: 1636 LHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSV 1695
L +++E+ E + ++ + + ET K + L +
Sbjct: 1324 LERSRERQE----------RRIQVTLRKWERFETNKETVVRYLFQT-------------- 1359
Query: 1696 GSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQ 1755
GSS + L+ +E LS +L++ E K R + + Q
Sbjct: 1360 GSSHERFLS-FSSLESLSS----------------------ELEQTKEFSK-RTESIAVQ 1395
Query: 1756 QQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQD 1815
+N + L P+ +Q+LQQ+ +KEQ E ++K ++ ++
Sbjct: 1396 AENLVKEASEIP---------LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKT 1446
Query: 1816 ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFV 1875
+ F + + W+ EKEL + S+ + S +K V + + +
Sbjct: 1447 KWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK--------VTIQEIESKLS 1498
Query: 1876 TISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTAL--HSKCTRLGSHLNMLLGQ 1933
+I G + + SF + E +K KL L H++C +LG
Sbjct: 1499 SIVGLE--EEAQSFAQFVTTGESAR-IKAKLTQIRRYGEELREHAQCLE-----GTILGH 1550
Query: 1934 YHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEK 1993
Q Q ++L+ Q+ D +A + T K LQE + Q +E
Sbjct: 1551 LSQQQKFEENLRKIQQSVSE-----FEDKLAVPIKICSSATETYKVLQEHMDLCQA-LES 1604
Query: 1994 LQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES 2053
L + VQE ++ ++ + ER + L+ +A Q +++
Sbjct: 1605 LSSAITAFSASARKVVNRDSCVQEAA-ALQQQYEDILRRAKERQTALENLLAHWQRLEKE 1663
Query: 2054 LESLLQSIGEVEQNLEGKQVSSLSSGV-IQEALATNMKLKQDIARQKSSLEATREMVTRF 2112
L S L + E ++ + V ++ L L+ ++ Q S ++
Sbjct: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723
Query: 2113 METADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMEN 2172
A +++ L ++ +R+ L ++ + L+ ++ + + F+ L ++
Sbjct: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI-- 1781
Query: 2173 KSRMLASGNQPDQDITHFFQQI-----QELNLEMEDQQENLDTLEHLVTELSSCGFALDL 2227
++ S Q +I+ Q+ ++ E+E ++ L +L+ + +L S G A DL
Sbjct: 1782 --KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDL 1839
Query: 2228 CQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLK--ETEGSIPP 2285
Q + ++ + F E + V+ R+ S E L L ++ + E S+
Sbjct: 1840 HLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
Query: 2286 TETSMSAKELEKQIEHLKSL------LDDWASKGTLVEEINCKGTSLENLIMEITAPDSQ 2339
E+ + K+L +++ K+L LD SK +I G+S + TA
Sbjct: 1900 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKI---GSSEQRTSCRATADQLC 1956
Query: 2340 GKTGSILPSVGSSVGSVNGYHTCK-----DLTEIQCDMSDVNLKYEKLGGVLHERQESLQ 2394
G+ I +G+ + K E+ + D+ + +K + +++LQ
Sbjct: 1957 GEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQ 2015
Query: 2395 AILNRMEEVHKEANS---VLQWLESKEEVLKSMDAMSSP---TKTETVKAQAESNKAFLA 2448
L ++ E NS L WL+ K + + D +P + ++ + K +
Sbjct: 2016 QRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIH 2075
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEES 2508
E + L L+ Y N + A + K+ E +S T T+ Q L+
Sbjct: 2076 ENQGQCC-------GLIDLMREYQNLKSAVS--KVLENASS--VIVTRTTIKDQEDLK-- 2122
Query: 2509 ASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHE 2568
W K K ++ + K+ + + +
Sbjct: 2123 ----------------WAFSKH----------------ETAKNKMNYKQKDLDNFTSKGK 2150
Query: 2569 QLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE 2628
L + I + D SL V+ +++S KW+++++KL +D+ V + + +
Sbjct: 2151 HLLSELKKIHS--SDFSL----VKTDMESTVDKWLDVSEKL---EENMDRLRVSLSIWDD 2201
Query: 2629 LLQDLSE----KVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSD---LEQLDHEVKEA 2681
+L E V Q S + A + E SE+++ LE+L +V +
Sbjct: 2202 VLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDL 2261
Query: 2682 QTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFD 2741
+ L L Q+++ +L ++LE +++ L+ A + Q ++ +
Sbjct: 2262 KELTKNLETPPDLQFIEADLMQKLEHA-------KEITEVAKGTLKDFTAQSTQVEKFIN 2314
Query: 2742 ELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS 2801
++ TW K + NC + E L+ +E Q + S + E + + L
Sbjct: 2315 DITTWF-TKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENL-----NSLCR 2368
Query: 2802 VPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCK 2861
E +L + L E +S+ + Q+ L++ ++K + +++ W K
Sbjct: 2369 KYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFLGAK 2426
Query: 2862 AKMSELR-VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADIL-INSSEADEDGIR 2919
A E T D LE+ L + +L+ V +S L+ + L + S+ I+
Sbjct: 2427 AAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQ 2486
Query: 2920 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG- 2978
++ N+ A ++ +L++ L F++ + + + + + + LG
Sbjct: 2487 EQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT-ENLGE 2545
Query: 2979 -SQACSNKNLEKLRAQQ---EVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA 3034
Q K E + + E+L A E +D L Q L E+ +L Q +
Sbjct: 2546 SKQHIPEKKNEVHKVEMFLGELLAARE-SLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS 2604
Query: 3035 QQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQ 3094
Q L + + C + + E + + ++ M+ + + D L + D+L+
Sbjct: 2605 HQNLLRMTKEKLRSCQVALQEHEALEE---ALQSMWFWVKAIQDRLACAESTLGSKDTLE 2661
Query: 3095 ---SQIEDVRLFLNKIHV-LKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL 3150
SQI+D+ L + V L + I E R +E + ++ +LE L + +
Sbjct: 2662 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRV----IQTQLETLKEVWADI 2717
Query: 3151 TERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFK 3210
Q LE + + D+ + L QW+ + +I +
Sbjct: 2718 MSSSVHAQSTLESVISQWNDYVERKNQLE------------QWMESVDQKIEHPLQPQPG 2765
Query: 3211 MFQK-EQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHD-------MEEINARWNTLN 3262
+ +K +D LQ L + + L + K ++ D EE+ ++N +
Sbjct: 2766 LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIM 2825
Query: 3263 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3322
+++ +++E + + DA+ WL +E + S + + ++ +
Sbjct: 2826 TVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSK--- 2882
Query: 3323 LQRLLDDRK---ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379
++ L+D R+ + + +++ + Q+ + E + ++++L + W + Q
Sbjct: 2883 IKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQS 2942
Query: 3380 QLEDI---LVLAK--------QFHETAEPISDFLSVTEKKLANSEPVGTQTA------KI 3422
LE++ + L++ Q + E S L ++L E T K
Sbjct: 2943 CLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKG 3002
Query: 3423 QQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDR 3482
Q+ + + E E+ + +++ + + LS+ + G +S I +
Sbjct: 3003 QEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS-----GKVSGLIKEYNCLCLQASKG 3057
Query: 3483 CCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALN 3542
C K +L Q A + WL V K+++ D Q++ + + L
Sbjct: 3058 CQNKEQILQQRFRKAFR------DFQQWL--VNAKITTAKCFDIPQNI--SEVSTSLQKI 3107
Query: 3543 EEIVNRKKN----VDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRT 3598
+E ++ +N ++ + G+ L T E+ IQ K+ K + + +
Sbjct: 3108 QEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESA 3167
Query: 3599 LEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR 3658
LE + F+ + E + WL + E+ + S + + QQ+ + + +E+ +
Sbjct: 3168 LENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYE 3227
Query: 3659 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 3718
L+ + E ++ L E A + VS + QY +S+ ++V +D + Q+
Sbjct: 3228 PQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQF 3285
Query: 3719 EQAADAELAWVAETKRKLMA-LGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHR 3777
W+ + L + P + + L+++ S+ + K+ ++ R
Sbjct: 3286 SLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK--QEKEIQMKMIVTR 3343
Query: 3778 SE-IFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 3836
E + E +Q++ +S+ + ++ ++LE A + + + S
Sbjct: 3344 GESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG 3403
Query: 3837 WIEETRALIAQLPSPAIDHEQLRQQQE---EMRQLRESIAEHKPHIDKLLKIGPQLKELN 3893
W++ ++ A L H +LR + + + L E + + ++ + ++K
Sbjct: 3404 WMD---SMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETI-----EVKGAG 3455
Query: 3894 PEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE--- 3950
E + + + Q + Y I+E + EAV++S ++ H + + L+ E
Sbjct: 3456 MTEHYVTQLELQDLQERYRAIQERAK-------EAVTKSEKLVRLHQEYQRDLKAFEVWL 3508
Query: 3951 -NLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4009
+L ++ + + D + V + Q ++ E++I +
Sbjct: 3509 GQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
Query: 4010 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDV---LELAEKFWYDMAALLTTIKDTQ 4066
D A + ++ W+ + R E +F +V L L E+ + + L T ++
Sbjct: 3569 DRALESLRQD-------WQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK- 3620
Query: 4067 DIVHDLESPGIDPSIIKQQVEAAETIK--------EETDGLHEELEFIRILGADLIFACG 4118
+ P +Q A + I+ EE +E+E + +++
Sbjct: 3621 ----------VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESH 3670
Query: 4119 ETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKL 4178
+ + + ++ + ++ L E+++ LE+ +Q+ + + +L + DW +T
Sbjct: 3671 VNSRMGCQAT--QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGST---H 3725
Query: 4179 CTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRD 4233
V T ++ V + K +EV + +E ++ +GE + K +E + +
Sbjct: 3726 KNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAV-KYLEEGEAE 3784
Query: 4234 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4293
+R+ + + + L + LE L +F + L W+ +E+L
Sbjct: 3785 RLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
Query: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4353
+ + +L+K+ L+ VL+H+ +V++V + G LLE +L+ +++ +
Sbjct: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV---QDVTLKDKIDQLQS 3901
Query: 4354 CWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASK--PTGGLPETAR 4411
++ + +E L++ ++ + ++SE+++ L +M +L A T L ET
Sbjct: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSL-ETIT 3960
Query: 4412 EQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLE---QKWHVV 4468
+QL H + ++ E+ N L KG ++ D + A L+ + +
Sbjct: 3961 QQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 4020
Query: 4469 SSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHK 4528
S + LE L Q++LQ+ WL+ + L + P L + Q++ +
Sbjct: 4021 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR 4080
Query: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588
+ + D + + N +K +Q + E+ +++ + + ++L
Sbjct: 4081 ALQEQARTYLDLLCSMCDLSN-----------ASVKTTAKDIQ-QTEQTIEQKLVQAQNL 4128
Query: 4589 DDARKRAKQFHEAWKKLIDWLEDAESHLD------SELEISNDPDKIKLQLSKHKEFQKT 4642
+ K +L +L+DA+ L SELE++ + + S+ K+F K
Sbjct: 4129 TQGWEEIKHLK---SELWIYLQDADQQLQNMKRRHSELELNIAQNMV----SQVKDFVKK 4181
Query: 4643 LGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEAL 4702
L KQ +T I L +K PE + + + D+W +C +S + EE L
Sbjct: 4182 LQSKQASVNTIIEKVNKLTKKEESPEHKE-----INHLNDQWLDLCRQSNNLCLQREEDL 4236
Query: 4703 LFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQV 4762
+ + D + + +L K + D D + ++A K L +R ++
Sbjct: 4237 QRTRDYHDCMNVVEVFLEKFTTEW--DNLARSDAESTAVHLEALKKLALALQERKYAIED 4294
Query: 4763 LKRSGRELIEN-SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVH 4821
LK +++IE+ + DD VK Q L RW + L K L++ V +
Sbjct: 4295 LKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQ 4354
Query: 4822 MLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAV 4881
L+EW E + + + Q+L+ H ++E K++ + S + + ++A
Sbjct: 4355 ELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMAD 4414
Query: 4882 CHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAET 4941
+ I+ ++ ++ + Q ++ L ALSE + + + IQ E
Sbjct: 4415 LGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHER 4474
Query: 4942 TLIQRDQ-----EPIPQNIDRVKALIAEHQTFMEEMT 4973
++ R+ + + + + K+ A +T+ E+T
Sbjct: 4475 KIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVT 4511
Score = 282 bits (722), Expect = 6e-75
Identities = 753/3999 (18%), Positives = 1550/3999 (38%), Gaps = 510/3999 (12%)
Query: 1204 LSDVKDKNSVFSVLDEEIAKAKVVAEQMS-----RLTPERNLDLERYQEKGSQLQERWHR 1258
L D++++ + EE+ + + +S + T + L + ++L E
Sbjct: 4917 LQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGD 4976
Query: 1259 VIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQ 1318
+ L RQ+ L I Y W+E+ AQ+ + G D E L
Sbjct: 4977 IQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED--AQELLQLAGNGLDVESAEENLKS 5034
Query: 1319 QTALFAEIERNQTKLDQCQKFSQQYSTIVK-----DYELQLMTYKAFVESQQKSPGKRRR 1373
F+ ++ + L++ ++K D E ++ + + + + G +
Sbjct: 5035 HMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVD 5094
Query: 1374 MLSSSDAITQEFMDLRTRYTALVTLTTQHVKYIS--------DALRRLEEEEKVVEEEKQ 1425
+L A ++ R L+ T + + S +A +L E + +V
Sbjct: 5095 LLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNS 5154
Query: 1426 EHVEKVKELLGWVSTLAR--NTQGKATSSETKES-----TDIEKAILEQQVLSEELTTKK 1478
H EK+ L S L + N KAT S + + T + +Q+ + E+ +
Sbjct: 5155 FH-EKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEW 5213
Query: 1479 EQVSEAIKTSQIFLAKHGHKL--SEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQL 1536
+ +K + + + KL S EK +E L L YHD Q Q L
Sbjct: 5214 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLE--YHDTFVLELEQQQSALGML 5271
Query: 1537 AHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQ-----GRTTQQDLSALQKNQSD 1591
QT T ++ + +R L + G+ +Q+L + ++
Sbjct: 5272 RQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQ 5331
Query: 1592 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQ--------Y 1643
+ ++ +Q +I+ +EE Q L+ E T R+ + + E+ Y
Sbjct: 5332 INSVKCWVQETKEYLGNPTIEIDAQLEELQILLT--EATNHRQNIEKMAEEQKEKYLGLY 5389
Query: 1644 EALQEET--RVAQKELEEAVTSALQ---QETEKSKA-----AKELAENKKKIDALLDWVT 1693
L E ++A+ L+ + +Q +E E+SKA ++++ + K + +L +
Sbjct: 5390 TILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLK 5449
Query: 1694 SVGSSGGQLLTNLPGM-EQLSGASLEKGALDTT-DGYMGVN-QAPEKLDKQCEMMKARHQ 1750
+ + Q T+ + E+L G + + LD ++ N Q + L K+ + HQ
Sbjct: 5450 AKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQ 5509
Query: 1751 ELLSQQQNFILATQSAQAFLDQ-------------------HG----------------H 1775
+ + Q +N + A + L++ HG H
Sbjct: 5510 QTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILH 5569
Query: 1776 NLTPEEQQMLQQKLGELKE--QYSTSLAQSEAELKQVQTLQDE--------------LQK 1819
EE + + +L + E QY TS+ +E +QV L E LQ
Sbjct: 5570 QTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQD 5629
Query: 1820 FLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISG 1879
+D K+FE+ L++ + LE +SPE LK Q S + ++S L+
Sbjct: 5630 AAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV--- 5686
Query: 1880 QKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN 1939
Q V +++ + ++ L L+ E H+ + + + QY Q++
Sbjct: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI-MQAAVVQYEQYEQ 5745
Query: 1940 SADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 1999
LQ ++ +E S+ LQ Q++ ++L +++ +Q + L +
Sbjct: 5746 EMKHLQQLIEGAHREIED--KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCK 5803
Query: 2000 DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLES-LL 2058
++ ++ + A V E + + + L L S + + +L S +
Sbjct: 5804 -MLTMKAKHATMLLTVTEV-EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
Query: 2059 QSIGEVEQNLE---------GKQVSSLSSGVIQE-----ALATNMKLKQDIARQKSSLEA 2104
+ GE N E V++ + V Q+ AL+ +L+ D A+ S A
Sbjct: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAE-RLQTDAAKIHPSTSA 5920
Query: 2105 TREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH--- 2161
++E +E S TA KL ++ + +E L EK+ +L + L + + ++
Sbjct: 5921 SQEFYEPGLEP--SATA-----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQ 5973
Query: 2162 -LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL-EHLVTELS 2219
+S K++ S G P+ + + E+ + ++ E +L E LV+E
Sbjct: 5974 SISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESC 6033
Query: 2220 SCGFALDLCQHQ------DRVQNLRKDFTELQKTVKEREKDASSCQEQ---LDEFRKLVR 2270
A L +R+ +R + ++ ++E+ D Q Q L +R
Sbjct: 6034 EADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEAD 6093
Query: 2271 TFQKWLKETEGSI-----PPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTS 2325
WL T+ ++ PP E ++E Q+ +++L + K + E++
Sbjct: 6094 ELDSWLLSTKATLDTALSPPKEPM----DMEAQLMDCQNMLVEIEQKVVALSELSVHN-- 6147
Query: 2326 LENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGV 2385
ENL++E GK HT + ++ + + +L
Sbjct: 6148 -ENLLLE-------GKA-----------------HTKDEAEQLAGKLRRLKGSLLELQRA 6182
Query: 2386 LHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKA 2445
LH++Q ++Q + KEE + A SP E + AQA +
Sbjct: 6183 LHDKQLNMQGTA-----------------QEKEESDVDLTATQSPGVQEWL-AQARTTWT 6224
Query: 2446 FLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQL 2505
+Q +Q+ KE QE K + + SR E
Sbjct: 6225 -----QQRQSSLQQQKEL----------EQELAEQKSLLRSVASRGE------------- 6256
Query: 2506 EESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEF---EA 2562
E H A + ++ +P ++ +EL M + D + + +F K+
Sbjct: 6257 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 6316
Query: 2563 RRQQHEQL-----NEAAQGILTGPGDV-SLSTSQVQKELQSINQKWVELTDKLNSRSSQI 2616
Q+ EQ+ N G+ GDV + S V L +NQ + E+ SSQ
Sbjct: 6317 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV-------SSQS 6369
Query: 2617 DQAIVKSTQYQELLQD----LSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLE 2672
A +S ++ L D S + V +RL V +A+ PE + L + D++
Sbjct: 6370 GGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALL--PEETETCLFNQEILAKDIK 6427
Query: 2673 QLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALAS 2732
++ E+ + + L + G+ +D ++ L + L L+ + R ++++ L
Sbjct: 6428 EMSEEMDKNKNLFSQAFPENGDN--RDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQ 6485
Query: 2733 TQQFQQMFDELRTWLDDKQS---QQAKNC---PISAKLERLQSQLQENEEFQKSLNQHSG 2786
FQ L T L D + Q+ N P++ ++E +Q +EF + +
Sbjct: 6486 ILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE--- 6542
Query: 2787 SYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKY 2846
+ G+ L + P +E L +L++ ++EL R+S L + +Y
Sbjct: 6543 ----LKRRGDKLQVEQPSMQE-------LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQY 6591
Query: 2847 QWHVEDLVPWIEDCKAKMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAA 2904
+ ++DL +E + KM+ + + +++ L + K +E L E L
Sbjct: 6592 ERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRK- 6650
Query: 2905 DILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKV 2964
+I+ + E E + AV + + LE + E++ ++++
Sbjct: 6651 --IISFAVQKETQFHTE---LMAQASAVLKRAHKRGVELEYIL-------ETWSHLDEDQ 6698
Query: 2965 EGAKHQLEIFDA-LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGS- 3022
+ QLE+ ++ + S +N ++L + + Q L+ L + L + DG
Sbjct: 6699 QELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS---LNEYQPKLYQVLDDGKR 6755
Query: 3023 -----DASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD 3077
S L Q + +L +++ +E L+ ++ ++ L
Sbjct: 6756 LLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAK 6815
Query: 3078 DELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTL------ 3131
D L+ + + ++ ++E VR LN +++A + +L L
Sbjct: 6816 DRLEFWT---QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV 6872
Query: 3132 DLLGLKRELEALNKQCGKLTERGKARQEQL-ELTLGRVEDFYRKLKGLNDATTAAEEAEA 3190
D L+ EL ++ Q L A QE+L +L + ++ + + ++ + +
Sbjct: 6873 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQK 6932
Query: 3191 LQWVVGTEV--EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDC-----D 3243
+ + + + I++ L +K F+ + + K V+ + Q ++Q + +D D
Sbjct: 6933 DEDNIKNSIGYKAIHEYLQKYKGFKID----INCKQLTVDFVNQSVLQISSQDVESKRSD 6988
Query: 3244 VQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQ 3303
+ +N W L V ++I L+ L ++++ ++ L +W +T+E Q
Sbjct: 6989 KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF-ETQEKRLKQ 7047
Query: 3304 KPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESL 3363
+ + V+ +++ + L+ L+ ++ V+ ++ G + Q+ + + L L
Sbjct: 7048 QHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLREL 7107
Query: 3364 ESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQ 3423
W L + L+ +L + I+ +L L+ + +Q
Sbjct: 7108 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 7167
Query: 3424 QQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC 3483
Q+ + L++D+E + + I L P L+ + + R++ + +
Sbjct: 7168 VQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 7227
Query: 3484 CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNE 3543
+ L + + + + + + + ED+ + + +D+ + A +
Sbjct: 7228 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCN 7287
Query: 3544 EIVNRKKNVDQAI----KNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTL 3599
+++ V ++ + G+ L +Q IQ + + K +L
Sbjct: 7288 DLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSL 7347
Query: 3600 EQARQLATKFQSTYEELTGWLREVEEELATSGGQSPT-GEQIPQFQQRQKELKKEVMEHR 3658
+ F + E L W+ E EE L GQ P+ + Q+R +ELK ++++
Sbjct: 7348 QAGVLDYETFAKSLEALEAWIVEAEEILQ---GQDPSHSSDLSTIQERMEELKGQMLKFS 7404
Query: 3659 LV---LDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS 3715
+ LD +NE+ L P +E K + + N + L+S +R ++ + + +
Sbjct: 7405 SMAPDLDRLNELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQH 7458
Query: 3716 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFS 3775
Q + + + + ++ +T++KL + + + L+ Q+A H+ E+FS
Sbjct: 7459 QTFLEKCETWMEFLVQTEQKLA----VEISGNYQHL-LEQQRA-------HELFQAEMFS 7506
Query: 3776 HRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQ----VLVNQF--WE 3829
+ + + Q+ + Q + + + ++LL+++ + RAQ ++ +Q W+
Sbjct: 7507 RQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQ 7566
Query: 3830 TY----EELSPWIEETRAL-IAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLK 3884
Y E+L W+ E L ++ L S I +Q R +E++ + + ++
Sbjct: 7567 RYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE 7626
Query: 3885 IGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEP 3944
G QL L+ + G E +AE A+I+E+ + ++ L+E + + + +K E
Sbjct: 7627 AGKQLL-LSADSGA---EAALQAE--LAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEK 7680
Query: 3945 -MLETLENLSS-RLRMPPLIP-------AEVDKIREC----------------ISDNKSA 3979
+ ++LE L + + ++ +P AE + +E + D SA
Sbjct: 7681 GIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA 7740
Query: 3980 TV---ELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEE 4036
+ ++ L E L+R+ EEL + L ++I ++L++ F E K
Sbjct: 7741 YISADDISILNERVELLQRQWEELCHQLS-----LRRQQIGERLNEWAVFSEKNK----- 7790
Query: 4037 REIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEET 4096
EL E W + + + + DI +I++ +E + +E
Sbjct: 7791 ---------ELCE--W--LTQMESKVSQNGDI------------LIEEMIEKLKKDYQEE 7825
Query: 4097 DGLHEELEF-IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQ 4155
+ +E + ++ +G L A E++ E+ + ++N+ W++L R++KL++ +
Sbjct: 7826 IAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLV 7885
Query: 4156 AAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNT--VKDQLNEMKEFKVEVYQQQIEME 4213
A Q + ++ WL + +L P V N+ ++ +LNE +E + ++ + +
Sbjct: 7886 AVQQLDKNMSSLRTWLAHIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVA 7944
Query: 4214 KLNHQGELMLKK----ATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQ 4269
+ + E++L ATD + D I++ L W N+ R+ K+E +
Sbjct: 7945 SVLNLCEVLLHDCDACATD-AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQK 8003
Query: 4270 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG 4329
F WL +E V + EL K + V +E +NK
Sbjct: 8004 FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQY 8063
Query: 4330 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4389
L + D A SL+ + NQ W+++ ++ ++L+ + Q + F + + L+
Sbjct: 8064 RRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVW 8123
Query: 4390 LTRMESQLSASKPTGGLPETAR-EQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDS 4448
LT M+ QL+ + A+ +QL + ++ Q++ +G L+ + +
Sbjct: 8124 LTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ---EISLNHNKIEQIIAQGE-QLIEKSEP 8179
Query: 4449 GSGSKTEQSVALLEQKWHVVSSKMEERKSKL--------EEALN---LATEFQNSLQEFI 4497
+ E+ + L + V ++E KL E L+ L E +L + +
Sbjct: 8180 LDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSD-L 8238
Query: 4498 NWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQK 4557
+W + SL ++ PS L+ L+Q + + A D I L
Sbjct: 8239 HWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIP-----------LEWD 8286
Query: 4558 QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA----KQFHEAWKKLIDWLEDAE 4613
D L ++L +S + + E G+ D R H A + I L A
Sbjct: 8287 HDYDLSRDL----ESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKAL 8342
Query: 4614 SHLDSELEISNDPDKIKLQL-------SKHKEFQKTLGGKQPVYDTTIRTGRALKEKT-L 4665
DS +I + I+ + + +K + K LG D+ R LKE+
Sbjct: 8343 D--DSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES 8400
Query: 4666 LPE--DSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 4723
LP + + V D+W+ + +++ ++ ++++ L QF L ++ WL E
Sbjct: 8401 LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 8460
Query: 4724 PQLAEDQPVHGDLDLVMNLMDAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 4781
+L + Q + D+ + K+ QK + R + + E + ++ +
Sbjct: 8461 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 8520
Query: 4782 KGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALP 4841
+ +L +++ RWD VC L + L+ AL Q + F + H LL L ++ R +P
Sbjct: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVP 8578
Query: 4842 DDTEA-LQSLIDTHKEFMK---KVEEKRVDVNSAVAMG-EVILAVCHPDCITTIKHWITI 4896
D+ + L D HK+ M+ ++ E ++ V S M ++++ DC+ K + +
Sbjct: 8579 IDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHV 8637
Query: 4897 IRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAW 4935
I R + +L +H + LE L V++++ ++L +W
Sbjct: 8638 IGNRLKLLLKEVSRHIKELEKLLD--VSSSQ--QDLSSW 8672
Score = 277 bits (708), Expect = 2e-73
Identities = 782/4130 (18%), Positives = 1624/4130 (39%), Gaps = 503/4130 (12%)
Query: 675 RMRHLQSLHKFVSRATAELIWLNE------KEEEELAYDWSDNNSNISAKRNYFSELTME 728
+M HL +L+ + R T + + L E +E E++ ++ +++ +E T+
Sbjct: 4751 KMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLP 4810
Query: 729 LEEKQDVFRSL----QD--------TAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCL 776
EEK ++ SL QD T L L H E +QS +K L
Sbjct: 4811 AEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTS 4870
Query: 777 CVEQHVKENTAYF----QFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSM 832
+ + V E + F ++ +LR ++ + D N L +++ ++
Sbjct: 4871 AIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLN--LQDIQEEIRKIQ 4928
Query: 833 DEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDEC 892
+E++ S + +L + K L+++++ + D I+ +
Sbjct: 4929 IHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD-GDIQEALRTRQAT 4987
Query: 893 VLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHV 952
+ E SQ ++ + N+ + + L N +E A +S+ + + Q H
Sbjct: 4988 LTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHS 5047
Query: 953 NTKSLISWNYLRKDL-------DLVQTWNLEKLRSSA----PGECHQIMKNLQAHYEDFL 1001
N + L S L DL Q +LRS G +++ A + D+
Sbjct: 5048 NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY- 5106
Query: 1002 QDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLE 1061
Q +R+ V+ + D + E K H E + E ++ + LE
Sbjct: 5107 QKAREEVIELMNDTEKKLSEFSLLKTSSSH---EAEEKLSEHKALVSVVNSFHEKIVALE 5163
Query: 1062 EYEQRVVKRIQSLAS---SRTDRDAWQD-NALRIAEQEHTQ------EDLQQLRSDLDAV 1111
E ++ K + SR+ WQ LR Q+ + ++ + +
Sbjct: 5164 EKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKA 5223
Query: 1112 SMKCDSFLHQSPSSSSVPTLRSELNLLVEKMD-HVYGL----STVYLNKLKTVDVIVRSI 1166
+ D + P SS+ ++EL L+E D V L S + + + +T+ ++
Sbjct: 5224 TEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSML---- 5279
Query: 1167 QDAELLVKGYEIKLSQEEVVLAD--LSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKA 1224
QD G E L QE + D L+ E + + ++KD+ V + ++
Sbjct: 5280 QDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWV 5339
Query: 1225 KVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACH 1284
+ E + T E + LE Q ++ + E E ++ LG Y
Sbjct: 5340 QETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAE------EQKEKYLGLYTILP 5393
Query: 1285 GTLIKWIEETTAQQEMM-----KPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKF 1339
L + E ++ K + E S+ S++LS+Q QK
Sbjct: 5394 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQI----------------QKL 5437
Query: 1340 SQQYSTIVKDYELQLMTYKAF-VESQQKSPGKR----RRMLSSSDAITQEFMD------- 1387
++ +TI+ +L+ T ++ QK G+ L DA Q+F++
Sbjct: 5438 AKDLTTILT--KLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGK 5495
Query: 1388 -LRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVS---TLAR 1443
L + L L Q ++ + L +L + +EE + E ++ +L W+ LA
Sbjct: 5496 PLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE----YNEMLELILKWIEKAKVLAH 5551
Query: 1444 NTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIK--TSQIFLAKHGHKLSE 1501
T ++S+ +E + + +LE+ S+E+ ++ E ++E ++ TS K +++E
Sbjct: 5552 GTIAWNSASQLREQYILHQTLLEE---SKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5608
Query: 1502 KEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCS 1561
++ +E+L + K +A +++ +++L + Q L++ Q T S
Sbjct: 5609 LGRE--TEELRQMIKIRLQNLQDAAKDMKKFEAEL--KKLQAALEQAQATLTSPEVGRLS 5664
Query: 1562 WVGQ-AERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN 1620
Q + R + + + + A+Q QS L+ +D + + A + E ++
Sbjct: 5665 LKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQH 5724
Query: 1621 QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEE--AVTSALQQETEKSKAAKEL 1678
+ A + Q +++ + LQ+ A +E+E+ TS +Q+ + +EL
Sbjct: 5725 TAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEEL 5784
Query: 1679 AENKK-------KIDALLDWVTSVGSSGGQLLTNLP------GMEQLSGASLEKGALDTT 1725
A+ K +++ +T LLT G E L G L + +
Sbjct: 5785 AQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPS 5844
Query: 1726 -------------------DGYMGVN---------QAPEKL---DKQCEMMKARHQELLS 1754
G G N ++P + D A +Q L +
Sbjct: 5845 VVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSA 5904
Query: 1755 QQQNFILA-----TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ 1809
++ A T ++Q F + P + KLG+L+ + T + +
Sbjct: 5905 ERLQTDAAKIHPSTSASQEFYE-------PGLEPSATAKLGDLQRSWETLKNVISEKQRT 5957
Query: 1810 VQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHK 1869
+ + QK+ + + +E E +L + G SPE S + + ++++ +
Sbjct: 5958 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILMLQ 6014
Query: 1870 GDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTR----LGS 1925
++ + S + L E+ + E + + L ER + + K + L
Sbjct: 6015 DEINELQSSLAEELVSESCEADPAEQLAL----QSTLTVLAERMSTIRMKASGKRQLLEE 6070
Query: 1926 HLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQ 1979
LN L + Q ++ AD L +W+ + +A ++ LS +P ++ QL +
Sbjct: 6071 KLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQN 6128
Query: 1980 LQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE-RSS 2038
+ E+ + V + +L V + + +EG+ H ++ + + + L SL E + +
Sbjct: 6129 MLVEIEQKVVALSELS-VHNENLLLEGKA-----HTKDEAEQLAGKLRRLKGSLLELQRA 6182
Query: 2039 LLQKAIAQSQSVQESLES-----LLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQ 2093
L K + + QE ES QS G E + + + Q +L +L+Q
Sbjct: 6183 LHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQR---QSSLQQQKELEQ 6239
Query: 2094 DIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLL 2153
++A QKS L R + +R E +AA G E Q + EK S+ ++
Sbjct: 6240 ELAEQKSLL---RSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
Query: 2154 PQAE-MFEHLSGK---LQQFMENKSRM--------------LASGNQPDQDITHFFQQIQ 2195
+ E + + S K LQ +E + L G+ P QD + +
Sbjct: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLD 6356
Query: 2196 ELNLEMED--------QQENLDTLEHLVTELSSCGFALDLCQHQDRVQN-LRKDFTELQK 2246
LN E+ +++++ + L +S+ LD + + V L + TE
Sbjct: 6357 GLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCL 6416
Query: 2247 TVKE-REKDASSCQEQLDEFRKLVRTF-------QKWLKETEG------SIPPTETSMSA 2292
+E KD E++D+ + L + +++T G S+ + +
Sbjct: 6417 FNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRC 6476
Query: 2293 KELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSLENLIMEITAPDSQGKTGSILP 2347
+++++++ + + +D T + + + E + E Q + G
Sbjct: 6477 HQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEF 6536
Query: 2348 SVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2407
G G + +Q ++S + Y++L ++ R+ L L + +
Sbjct: 6537 DAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERAL 6595
Query: 2408 NSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL 2467
+ LE+ +E + + +K E ++ + +K + LE + + E L
Sbjct: 6596 QDLADLLETGQEKMAGDQKIIVSSKEE-IQQLLDKHKEYFQGLESH----MILTETLFRK 6650
Query: 2468 LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 2527
++++ +E + ++ + ++ +RA + V + LE + SHL + +L L
Sbjct: 6651 IISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE-TWSHL---DEDQQELSRQLE 6706
Query: 2528 EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 2587
E + +G + + + L + Q + + + Q+ + + +L +S+S
Sbjct: 6707 VVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLL-----ISIS 6761
Query: 2588 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 2647
S ++ +L + + W+ T+K++ +++ + T+YQ DL +++ RL
Sbjct: 6762 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6821
Query: 2648 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 2707
+ Q V Q+LE + + + EV +AQ+ + G Q L+ K+++T
Sbjct: 6822 TQ---QSVTVPQELEMVRDHLNAFLEFSKEV-DAQSSLKSSVLSTGNQLLR---LKKVDT 6874
Query: 2708 VAL--PLQGLEDLAADRINRLQAALASTQQFQQ-------MFDELRTWLDDKQSQQAK-- 2756
L L ++ D + + A Q Q E+ +W+ ++ K
Sbjct: 6875 ATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDE 6934
Query: 2757 -NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-LSVPPGEEKRT---- 2810
N S + + LQ+ + F+ +N + + + +S+L +S E KR+
Sbjct: 6935 DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFV---NQSVLQISSQDVESKRSDKTD 6991
Query: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 2870
QL + W+ L ++ L+ ++ +Y+ +V+ L W E + ++ +
Sbjct: 6992 FAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRI 7051
Query: 2871 LDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMD 2930
D ++++L + + + ++ + +E + LI + + D I +
Sbjct: 7052 GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI----------VM 7101
Query: 2931 AVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNK-NLEK 2989
+ EL +L+ M +L+ +S + + + H++ FD + S + +L +
Sbjct: 7102 STLRELGQTWANLDHMVGQLKILLKSVLD-----QWSSHKVA-FDKINSYLMEARYSLSR 7155
Query: 2990 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVAQQEFL-----E 3040
R L+A++ QVD L+N L + GS +QLL + E L E
Sbjct: 7156 FRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKE 7215
Query: 3041 VKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDV 3100
V R N+ ++E E + Q + +++ + D + S Q ED
Sbjct: 7216 VNMRWNN---LLEEIAEQL-QSSKALLQLWQRYKDYS----------KQCASTVQQQEDR 7261
Query: 3101 RLFLNKIHVLKLDIEASEA-----ECRHMLEEEGTL-DLLGLKRELEALNKQCGKLTERG 3154
L K K DI E +C +L+ GT+ D L EL KQ +
Sbjct: 7262 TNELLKAATNK-DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
Query: 3155 KARQEQLELT--LGRVEDFYRKLK-----GLNDATTAAEEAEALQ-WVVGTEVEIINQQ- 3205
+ +QL L+ L +E K + G+ D T A+ EAL+ W+V E EI+ Q
Sbjct: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE-EILQGQD 7379
Query: 3206 ---LADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDVQGLE-HDMEEINARWN 3259
+D Q E+++ L+ ++ + + + L + G + E M+ +N W+
Sbjct: 7380 PSHSSDLSTIQ-ERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWS 7438
Query: 3260 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQE 3319
++ + +R ++LQ LL F + E + +L TE+ +A + S Y+ + Q +
Sbjct: 7439 LISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SGNYQHLLEQQRA 7496
Query: 3320 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379
+L Q + R+ + + +G R+ + ++ DR++ +L L ++W ++ +A R+
Sbjct: 7497 HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRG 7556
Query: 3380 QLEDILVLAKQFHETAEPISDFL---SVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3436
++ + +++ E AE + +L S S P+ Q A+ ++ K E+
Sbjct: 7557 IIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFK--EKVF 7614
Query: 3437 ENHATDVHQAVKIG-QSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495
V+ G Q L S S AE +LQA +EIQ++ + L++
Sbjct: 7615 LRQQGSYILTVEAGKQLLLSADSGAEA--------ALQAELAEIQEKWKSASMRLEEQKK 7666
Query: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQA 3555
+D + +A+ +KL + FK+ + H L+ E + R K ++ A
Sbjct: 7667 KLAFLLKDWEKCEKGIADSLEKL-----RTFKKKLSQSLPDHHEELHAEQM-RCKELENA 7720
Query: 3556 IKNGQ------ALLKQT-----TGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ 3604
+ + +LLK T + +++ ++ E+++ ++ ++ ++ S + + +
Sbjct: 7721 VGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLN 7780
Query: 3605 LATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV 3664
F +EL WL ++E +++ +G E I + ++ +E E+++ L +
Sbjct: 7781 EWAVFSEKNKELCEWLTQMESKVSQNG-DILIEEMIEKLKKDYQEEIAIAQENKIQLQQM 7839
Query: 3665 NE-VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 3723
E +++A E +A E ++ + N++++ + D I RV ++ + QQ ++
Sbjct: 7840 GERLAKASHES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMS 7895
Query: 3724 AELAWVAETKRKLMALGPIRLEQ---DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 3780
+ W+A + +L PI + ++ +L Q+ DI +H + + + +
Sbjct: 7896 SLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVL 7953
Query: 3781 FGTCG----EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 3836
C + + +Q+ T +L +++ I ++ ER ++E L +F + Y
Sbjct: 7954 LHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFED 8013
Query: 3837 WIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 3896
W++ + A S + + +++ ++ + + E ++ + K +L N +
Sbjct: 8014 WLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 8073
Query: 3897 G-----EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLEN 3951
+MV E Q+ +N+ ++ +R+ L + Q + D I L ++
Sbjct: 8074 SACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARDSILVWLTEMD- 8128
Query: 3952 LSSRLRMPPLIPAEVDKIREC-----ISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4006
L ++ EC I K+ E+ E + +GE+LI +S+
Sbjct: 8129 ---------LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEP 8179
Query: 4007 ADKDLAAKEIQDKLDQMVFFWEDIKARAE-------------------EREIKFLDVLEL 4047
D A I+++LD++ + +++ R E +RE++ D L
Sbjct: 8180 LD----AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL 8235
Query: 4048 AEKFWYDMAA-LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETD---GLHEEL 4103
++ W+D +A L + + + ++ L P + + ++I E D L +L
Sbjct: 8236 SDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDL 8295
Query: 4104 EFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDT 4163
E G+ +K + ++ L ++ + L+D+ Q ++
Sbjct: 8296 ESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENI 8355
Query: 4164 LQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF--KVEVYQQQIEMEKLNHQGEL 4221
+++ K T P + T L E V+ + +++ E+ + G +
Sbjct: 8356 IRS----------KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV 8405
Query: 4222 MLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWL 4281
L +T I R WE L + ++ +++ L QF L + +WL
Sbjct: 8406 NLHSTETQTAGVIDR---------WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 8456
Query: 4282 THTEELLDAQR--PISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGD 4339
TEE L+ + +S D + IE+++ K L+ V +A + ++N E ++ +
Sbjct: 8457 GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-K 8515
Query: 4340 DASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSA 4399
++ L+ RL MN W+ V EE LQ L Q QGFH LL L ++ + +
Sbjct: 8516 ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNE 8575
Query: 4400 SKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA 4459
P E L H + Q+K ++LL+ + +D S +
Sbjct: 8576 IVPIDS--NLDAEILQDHHKQLMQIK------HELLESQLRVASLQDMSCQLLVNAEGTD 8627
Query: 4460 LLE--QKWHVVSSKME---ERKSKLEEALNLATEFQNSLQEFINWLTLAE 4504
LE +K HV+ ++++ + S+ + L + +S Q+ +W + E
Sbjct: 8628 CLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 8677
Score = 276 bits (706), Expect = 4e-73
Identities = 828/4619 (17%), Positives = 1775/4619 (38%), Gaps = 642/4619 (13%)
Query: 628 SVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLK-ETSSFRMRHLQSLHKFV 686
S+EE SS+ + G +NF + A + K++T K +T ++ ++ H +
Sbjct: 3706 SLEESESSLSSYSDWYGSTHKNFK-NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLL 3764
Query: 687 SRATAE----LIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDT 742
A + + +L E E E L + D+ + + + M LE+ + + D
Sbjct: 3765 KSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDK 3824
Query: 743 --------AELLSLENHPAKQTVEAYSAAVQ-SQLQWMKQLCLCVEQHVK----ENTAYF 789
AE + + P + +E Y Q S+ + ++Q L E VK + A
Sbjct: 3825 CKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALL 3884
Query: 790 QFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLV 849
+ D L+ + LQ + S S LE ++D D +L + + + +
Sbjct: 3885 ELVQDVT-LKDKIDQLQSDYQDLCSIGKEHVFS-LEAKVKDHEDYNSELQEVEKWLLQMS 3942
Query: 850 GRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPT 909
GR L+ S + + + KA+ + + ED + K +
Sbjct: 3943 GRLVAPDLLETSSLETITQQLAHHKAMME-----------EIAGFEDRLNNLQMKGDTLI 3991
Query: 910 GN-----EAMVPSVCFLIPPPNKDAIE-MASRVEQSYQKVMALWHQL--HVNTKSLI--- 958
G +A + KD+ + S ++ YQ +L H+L HV+ + +
Sbjct: 3992 GQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQ---SLEHELQKHVSRQDTLQQC 4048
Query: 959 -SW-NYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRD----SVLFSV 1012
+W + ++ DL+ L + + + + ++ Y D L D SV +
Sbjct: 4049 QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTA 4108
Query: 1013 ADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISE----LKNIRLRLEEYE---- 1064
D + E+ +E + Q+L + E ++ +Y+ + L+N++ R E E
Sbjct: 4109 KDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIA 4168
Query: 1065 QRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPS 1124
Q +V +++ + A + + + +E+ + + ++ D +L
Sbjct: 4169 QNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE----INHLNDQWLDLCRQ 4224
Query: 1125 SSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTV-DVIVRSIQDAELLVKGYEIKLSQE 1183
S+++ R E + V+L K T D + RS DAE
Sbjct: 4225 SNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARS--DAE-----------ST 4271
Query: 1184 EVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLD-L 1242
V L L L ++ + D+KD Q ++ NLD
Sbjct: 4272 AVHLEALKKLALALQERKYAIEDLKD--------------------QKQKMIEHLNLDDK 4311
Query: 1243 ERYQEKGSQLQERWHR----VIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQ 1298
E +E+ S L++RW + + ++++ + LE + V ++ L++W EE
Sbjct: 4312 ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQE----LMEWAEE----- 4362
Query: 1299 EMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYK 1358
Q AE + D Q + I + E + M K
Sbjct: 4363 --------------------QQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLK 4402
Query: 1359 AFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEK 1418
+ ++ + L+ I + D ++ L L Q KY++ AL +
Sbjct: 4403 SLIKDADRVMADLG--LNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLM 4460
Query: 1419 VVEE---EKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELT 1475
V + + Q+H K+ + R +K+ + A + E+T
Sbjct: 4461 AVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVT 4511
Query: 1476 TKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ 1535
Q E +K +++E+EK ++ +L L Y + +++LQ+L+
Sbjct: 4512 GLWAQGRELMK-----------EVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4560
Query: 1536 LAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERAL--------AGHQGRTTQQDLSALQK 1587
L + K + + C W+ QA+ + T + +
Sbjct: 4561 LVSRKHFK----------EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILE 4610
Query: 1588 NQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTAL----REKLHQ----- 1638
+ ++L +Q + + +++ + PR+ + ++K ++
Sbjct: 4611 QSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAI 4670
Query: 1639 -AKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGS 1697
A+++Y +L E T + ELE + T+ A +E + A+LD V +G
Sbjct: 4671 LARKEYASLIELTTQSLSELEAQFLRMSKVPTDL--AVEEALSLQDGCRAILDEVAGLGE 4728
Query: 1698 SGGQLLTNLPGME-------------------QLSGASLEKGAL--DTTDGYMGVNQAPE 1736
+ +L G +L + ++ +L DTT Y + +
Sbjct: 4729 AVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQ 4788
Query: 1737 KLDKQCEMMKAR----HQELLSQQQNFILATQSAQAFLDQ---------HGHNLTP---- 1779
+L++Q + +K ++E L ++ + A + D H +L P
Sbjct: 4789 QLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDP 4848
Query: 1780 ----EEQQMLQQKLGELKEQYST---SLAQSEAELKQVQTLQDELQKFLQDHKEFESWLE 1832
+ + +Q GELK S ++ + E+ + Q Q E+ + L WL
Sbjct: 4849 LAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLD-------WLR 4901
Query: 1833 RSEKELENMHKGGSSPETLPSLLKRQGSFSEDV---------ISHKGDLRFVTISGQKVL 1883
R + EL + + + +++ E+V +SHK +F
Sbjct: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISA 4961
Query: 1884 DMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADS 1943
D+E+S E SE+ +++ L+ T ++S+C R Y FQ + D
Sbjct: 4962 DLEHSLAE---LSELDGDIQEALRTRQATLTEIYSQCQRY----------YQVFQAANDW 5008
Query: 1944 LQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIME 2003
L+ + + L ++ + E +T Q L E V L + + +
Sbjct: 5009 LEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGK 5068
Query: 2004 IEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2063
+ +++ S+ Q +S + LLQ+ AQ Q++ E +++ + +
Sbjct: 5069 ED---------LEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMND 5119
Query: 2064 VEQNL-EGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAA 2122
E+ L E + + SS +E L+ + L + + A E ++ +T + + A
Sbjct: 5120 TEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKA 5179
Query: 2123 VLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQ 2182
L + V QR+ +L Q++E L+ + + F + K + ++ L +
Sbjct: 5180 TLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSA 5239
Query: 2183 PDQ---DITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFA----------LDLCQ 2229
++ + LE+E QQ L L + G A ++
Sbjct: 5240 EKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITA 5299
Query: 2230 HQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIP-PTET 2288
QDR N+++ K VK+ KD + Q++ + W++ET+ + PT
Sbjct: 5300 MQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKC-------WVQETKEYLGNPTI- 5351
Query: 2289 SMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG--SIL 2346
E++ Q+E L+ LL + T+ I ++ + G +IL
Sbjct: 5352 -----EIDAQLEELQILLTE--------------ATNHRQNIEKMAEEQKEKYLGLYTIL 5392
Query: 2347 PSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKE 2406
PS S L E+ D+ + +K+ V + S Q + +++++ K+
Sbjct: 5393 PSELSL-----------QLAEVALDLKIRDQIQDKIKEVEQSKATS-QELSRQIQKLAKD 5440
Query: 2407 ANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAG 2466
++L L++K T+ V K EL+ + K+ ++ A+
Sbjct: 5441 LTTILTKLKAK---------------TDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQK 5485
Query: 2467 LLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL 2526
L N Q + K +L ++ R +L ++ASHL + + W+
Sbjct: 5486 FLEQ--NGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI 5543
Query: 2527 MEKELMMGVLGPLSIDPNMLNAQKQQV---QFMLKEFEARRQQHEQLNEAAQGILTGPGD 2583
+ + VL +I N + ++Q Q +L+E + + E + E Q + +
Sbjct: 5544 EKAK----VLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTS---- 5595
Query: 2584 VSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQR 2643
T ++ +++ + ++ EL + R + A +++ L+ L
Sbjct: 5596 -VYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAA------- 5647
Query: 2644 LSVQSAISTQPE----AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD 2699
L A T PE ++K+QL + S++E L +V+ Q LC ++ I E +
Sbjct: 5648 LEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQ-LCQS-ALRIPEDVVAS 5705
Query: 2700 ELKKRLETVALPLQG----LEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQA 2755
L AL LQ L+ A + N +QAA+ +Q++Q L+ ++ +
Sbjct: 5706 ---LPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIE 5762
Query: 2756 KNCPISAKLERLQSQLQENEE-------FQKSLNQHSGSYEVIV--AEGESLLLSVPP-- 2804
++ ++ LQ+Q+ +EE +Q+ + + +++ A+ ++LL+V
Sbjct: 5763 DKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVE 5822
Query: 2805 --GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKA 2862
E L +L+ + + TA R L L P E+
Sbjct: 5823 GLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTL----------------LSPVTEESGE 5866
Query: 2863 KMSELRVTLDPV-QLESSLLRSKAMLNE---VEKRRSLLEILNSAADILINSS---EADE 2915
+ + ++ P + S + + A +N+ + S + AA I ++S E E
Sbjct: 5867 EGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYE 5926
Query: 2916 DGIRDEKAG----INQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL 2971
G+ + ++ + + + K +L E +R +++Q+S ++I K+E +L
Sbjct: 5927 PGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAI--EL 5984
Query: 2972 EIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLR-NFTQGLVEDAPDGSDASQLLHQ 3030
++ ++ + + +A + + L+ +++ L+ + + LV ++ + A QL Q
Sbjct: 5985 KLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQ 6044
Query: 3031 A--EVAQQEFLEVKQRVNSGCVMMENKL----------EGIGQFHCRVREMFSQLADLDD 3078
+ V + ++ + + ++E KL + + ++ C E+ S L
Sbjct: 6045 STLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKA 6104
Query: 3079 ELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKR 3138
LD + ++ +++Q+ D + L ++IE + L L G
Sbjct: 6105 TLDTALSPPKEPMDMEAQLMDCQNML-------VEIEQKVVALSELSVHNENLLLEGKAH 6157
Query: 3139 ELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTE 3198
+ + GKL R K +L+ L K LN TA E+ E+ + T+
Sbjct: 6158 TKDEAEQLAGKL-RRLKGSLLELQRALHD--------KQLNMQGTAQEKEESDVDLTATQ 6208
Query: 3199 VEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARW 3258
+ + LA + +Q Q LQQ + ++E+ A
Sbjct: 6209 SPGVQEWLAQARTTWTQQ---RQSSLQQ---------------------QKELEQELAEQ 6244
Query: 3259 NTLNKKVAQRIAQL------QEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV 3312
+L + VA R ++ E G+ D L L + E+ A + +
Sbjct: 6245 KSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELG--MEGEKSSAEDQMRMKWESL 6302
Query: 3313 VKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAEL-------ADREKITGQLESLES 3365
+ +QKLLQ +L+ + V L + R+ L D+ +T L+ L
Sbjct: 6303 HQEFSTKQKLLQNVLEQEQEQV--LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQ 6360
Query: 3366 RWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSE---PVGTQTAKI 3422
+ E+ S++ ++Q + L ++ ++ S +L E++L + P T+T
Sbjct: 6361 AFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLF 6417
Query: 3423 QQQIIRH--KALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQ 3480
Q+I+ K + E+++ + QA + + V+ + + L R S +
Sbjct: 6418 NQEILAKDIKEMSEEMDKNKNLFSQAFP--------ENGDNRDVIEDTLGCLLGRLSLLD 6469
Query: 3481 DRCCRKAALLDQALSNARLFGEDEVEVLNWLAE----VEDKLSSVFVKDFKQDVLHRQHA 3536
++ + + L F D + LA+ + KL++VF + + + Q A
Sbjct: 6470 SVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQA 6529
Query: 3537 DH--LALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSK 3594
+ + I+ K+ D + ++Q + +E+ +Q+ Y ++ +
Sbjct: 6530 EDGLKEFDAGIIELKRRGD------KLQVEQPSMQELSKLQD-------MYDELMMIIGS 6576
Query: 3595 ALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQS---PTGEQIPQFQQRQKELK 3651
L Q L ++++ ++L L +E++A G Q + E+I Q + KE
Sbjct: 6577 RRSGLNQNLTLKSQYERALQDLADLLETGQEKMA--GDQKIIVSSKEEIQQLLDKHKEYF 6634
Query: 3652 KEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAA 3711
+ + H ++ +T + R ++ + + +L++ A+ K +R E++
Sbjct: 6635 QGLESHMILTET---LFRKIISFAVQKETQFHTELMAQASAVLKRAH----KRGVELEYI 6687
Query: 3712 IQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMD 3771
++ ++ + + + ++G + +D+ ++ + + K S++
Sbjct: 6688 LETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHL-------KSSLN 6740
Query: 3772 ELFSHRSEIFGTCGEEQKTVLQ---EKTESLIQQYEAISLLNSERYAR-LERAQVLVNQF 3827
E ++ +++ + ++ ++ ES + Q L N+ + ++ L R + ++ +
Sbjct: 6741 E---YQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETIL-KH 6796
Query: 3828 WETYE----ELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHID--- 3880
W Y+ +L W++ + + ++ + Q+ E +R + E +D
Sbjct: 6797 WTRYQSESADLIHWLQSAKDRLEFWTQQSV---TVPQELEMVRDHLNAFLEFSKEVDAQS 6853
Query: 3881 ----KLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQIT 3936
+L G QL L + + + + ++ + + + A+ E + Q
Sbjct: 6854 SLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIP----AVQEKLHQLQM-- 6907
Query: 3937 EFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEA---L 3993
DK+ E +S M +I + D I+ I K+ L+K + F+
Sbjct: 6908 ---DKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG-YKAIHEYLQKYK-GFKIDINC 6962
Query: 3994 KRRGEELIGRS--QGADKDLAAK-----EIQDKLDQMVFFWEDIKARAEEREIKFLDVLE 4046
K+ + + +S Q + +D+ +K + ++L M W+ ++ E+ +LE
Sbjct: 6963 KQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 7022
Query: 4047 LAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFI 4106
++ ++ L T + + + G D + ++ ++ + +++ +E+E I
Sbjct: 7023 SWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKAKEKEVEKI 7081
Query: 4107 RILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQA 4166
G LI E V ++ E+ W NL+ + +L+ +++ + + +
Sbjct: 7082 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLD----HMVGQLKILLKSVLDQWSSHKV 7137
Query: 4167 MFDWLDNTVIK----LCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELM 4222
FD +++ +++ L + L V+ Q++ ++ + ++ +Q+ ++K +
Sbjct: 7138 AFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQL 7197
Query: 4223 LKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLT 4282
LK+ + + L E+ W NL E+IA + + L +++ ++ S +
Sbjct: 7198 LKECHPPV-TETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQ 7256
Query: 4283 HTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVET----VNKAGNELLESSAG 4338
E+ + + + + + E+A ND+L TV+ +++ G +L +
Sbjct: 7257 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 7316
Query: 4339 DDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS 4398
AS+++S +++Q ++ Q +++ LQ+ + + F +E + E L
Sbjct: 7317 SAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQ 7376
Query: 4399 ASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLL-DKGRLMLLSRDDSGSGSKTEQS 4457
P+ L T E +LK + ++ + D RL L K +
Sbjct: 7377 GQDPSHS------SDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGY-RLPLNDKEIKR 7429
Query: 4458 VALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLIL 4517
+ L + W ++SS+ ER SKL+ L F + ++ +L EQ L + +
Sbjct: 7430 MQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGN--Y 7487
Query: 4518 NTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKV 4577
+L Q H++F E+ + + + + G +L Q D L + ++W+ V
Sbjct: 7488 QHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGV 7547
Query: 4578 VQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHK 4637
++R+ +R +D ++ +++ E +KL WL + S L P + L
Sbjct: 7548 IRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEV 7607
Query: 4638 EF-QKTLGGKQPVYDTTIRTGRALKEKTLLPEDS---QKLDNFLGEVRDKWDTVCGKSVE 4693
+F +K +Q Y T+ G+ L LL DS L L E+++KW + + E
Sbjct: 7608 QFKEKVFLRQQGSYILTVEAGKQL----LLSADSGAEAALQAELAEIQEKWKSASMRLEE 7663
Query: 4694 RQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKEL 4753
++ KL L + + ++ L + +L++ P H + + A ++ KEL
Sbjct: 7664 QKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE------ELHAEQMRCKEL 7717
Query: 4754 GKRTGT-------VQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRL 4806
G+ + +LK + I S DD + + +++ L +W+ +C ++ ++
Sbjct: 7718 ENAVGSWTDDLTQLSLLKDTLSAYI--SADDISILNERVELLQRQWEELCHQLSLRRQQI 7775
Query: 4807 EQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRV 4866
+ L + VF + L EWL++ E + G + + E ++ L ++E + +E ++
Sbjct: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIE-EMIEKLKKDYQEEIAIAQENKI 7834
Query: 4867 DVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANA 4926
+ MGE + H + I++ + + R++ +L ++L+ L +
Sbjct: 7835 QLQQ---MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD 7891
Query: 4927 ELLEELLAWIQWAETTLIQRDQEPIPQ---NIDRVKALIAEHQTFMEEMTRKQPDVDRV 4982
+ + L W+ E+ L +PI N + ++ + E Q ++ + V V
Sbjct: 7892 KNMSSLRTWLAHIESEL----AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASV 7946
Score = 266 bits (679), Expect = 5e-70
Identities = 796/4583 (17%), Positives = 1745/4583 (38%), Gaps = 596/4583 (13%)
Query: 400 DVEEEWGKLII-EMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADA 458
D E W + +M E +L + ELL + ++++N AL EE L N L+
Sbjct: 2207 DEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEE-LHSKVNDLKELT 2265
Query: 459 AHLESGQPVQ-CESDVIMYIQECEGLIRQLQVDLQILRDENYYQ---LEELAFRVMRLQD 514
+LE+ +Q E+D++ ++ + + + L+ ++ + ++ ++++
Sbjct: 2266 KNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE 2325
Query: 515 ELVTL-RLECTNLYRKGHFTSLELVPP-STLTTTHLKAEPLTKATHSSSTSWFRKPMT-- 570
L+ + E +K EL S +++T L + HS+ + MT
Sbjct: 2326 SLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGL 2385
Query: 571 --RAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEW--------------GNDLPS 614
+ E V+ S+ + +L+ E + E MQ E EW D
Sbjct: 2386 IKKHEAVSQLCSKTQASLQESLEK-HFSESMQ---EFQEWFLGAKAAAKESSDRTGDSKV 2441
Query: 615 VELQLETQQHIHTSVEELGSSVKEARLYEGK-----MSQNFHTSYAETLGKLETQYCKLK 669
+E +L Q+I SV + G S +A EG+ +S+ +S E + K ++
Sbjct: 2442 LEAKLHDLQNILDSVSD-GQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFL 2500
Query: 670 ETSSFRMRHLQS----LHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSEL 725
+ + LQ L F + +W++E EE + ++ +I K+N ++
Sbjct: 2501 KQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKV 2560
Query: 726 TM---ELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAV---QSQLQWMKQLCLCVE 779
M EL ++ L +LLS E H A Q S + Q+ L+ K+ +
Sbjct: 2561 EMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ 2620
Query: 780 QHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLI 839
++E+ A LE L+++ +K +QD + E +
Sbjct: 2621 VALQEHEA----------LEEALQSMWFWVK----------------AIQDRLACAESTL 2654
Query: 840 QSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQ 899
SK ++ + + + I+ ++K VK + + I K ++ + N +
Sbjct: 2655 GSKDTLEKRLSQIQDIL---------LMKGEGEVK-------LNMAIGKGEQALRSSNKE 2698
Query: 900 RTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLIS 959
+ ++ + + D + + + + + V++ W+ L
Sbjct: 2699 -----------GQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQ 2747
Query: 960 WNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSV-----LFSVAD 1014
W + +D +E PG + + L H + L ++ D L + +
Sbjct: 2748 W---MESVD----QKIEHPLQPQPGLKEKFV--LLDHLQSILSEAEDHTRALHRLIAKSR 2798
Query: 1015 RLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSL 1074
L + E E+ K Q +K+ N+ TVAK + +++ I Y V + L
Sbjct: 2799 ELYEKTEDESFKDTAQEELKTQFNDIM--TVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2856
Query: 1075 ASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF---------LHQSPSS 1125
S++ + W D + + TQ+ L +++ +D+ + + Q+ ++
Sbjct: 2857 HSAKEELHRWSDMS---GDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTA 2913
Query: 1126 SSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEV 1185
S + +E+ L + D +V+ +T + + L + + +++Q E
Sbjct: 2914 SGCELMHTEMQAL--RADWKQWEDSVF----QTQSCLENLVSQMALSEQEFSGQVAQLEQ 2967
Query: 1186 VLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERY 1245
L SAL W+ L+ ++ KN+ DEEI +
Sbjct: 2968 ALEQFSALLKTWA---QQLTLLEGKNT-----DEEIVEC--------------------- 2998
Query: 1246 QEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQ 1305
KG ++ + + + E +S+L + D G + I+E G
Sbjct: 2999 WHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGC 3058
Query: 1306 AEDSRVLSEQLSQQTALFAE-IERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQ 1364
++L ++ + F + + + +C Q S + L + F+
Sbjct: 3059 QNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEV----STSLQKIQEFLSES 3114
Query: 1365 QKSPGKRRRMLSSSDAITQEFMDLRTR-YTALVTLTTQHVKYISDALRRLE---EEEKVV 1420
+ K MLS + ++ + + A VT + K L + E E K+
Sbjct: 3115 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ 3174
Query: 1421 EEEKQEHVEKVKELLGWVSTLARNTQGKA--TSSETKESTDIEKAILEQQVLSEELTTKK 1478
++ + E +++ L + + + ++ +E ++ + E +L K
Sbjct: 3175 MKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLK 3234
Query: 1479 EQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAH 1538
E K Q++ + K Q+S Q AL+ +L ++L ++ +
Sbjct: 3235 E------KAQQLWEGQAASKSFRHRVSQLSSQYLALS----NLTKEKVSRLDRIVA---- 3280
Query: 1539 QTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDD 1598
+ N +++L W+ A L + T+ D S L L+ L
Sbjct: 3281 ---------EHNQFSLGIKELQDWMTDAIHMLDSYCHPTS--DKSVLDSRTLKLEALLSV 3329
Query: 1599 IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE 1658
Q + +V E ++ SP + ++++L K+ + +L + +LE
Sbjct: 3330 KQEKEIQMKMIVTRGESVLQNT----SPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLE 3385
Query: 1659 EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE 1718
AL + T ++ + W+ S+ + NL E+
Sbjct: 3386 ----GALSKWTSYQDGVRQFS----------GWMDSMEA-------NLNESER------- 3417
Query: 1719 KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLT 1778
Q E DK + KA+ LL+++ +L+ S ++ G +T
Sbjct: 3418 --------------QHAELRDKTTMLGKAK---LLNEE---VLSYSSLLETIEVKGAGMT 3457
Query: 1779 PEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL 1838
E + Q +L +L+E+Y +++ + + + L Q++ +D K FE WL + +++L
Sbjct: 3458 --EHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKL 3515
Query: 1839 ENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI 1898
+ S+L+ E + +L+ GQ +L+ +E PS I
Sbjct: 3516 DQY-----------SVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGI 3564
Query: 1899 GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKL 1958
L+ + + A + + + N ++ + + + W++ E V
Sbjct: 3565 PQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP- 3623
Query: 1959 LSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQE- 2017
S+ + QL K+ EE+ ++ VE++ A++I+ D HV
Sbjct: 3624 -RTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL--------DESHVNSR 3674
Query: 2018 ---TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLE--GKQ 2072
+ S +Q+L + E+ L++ I + + SL S G +N + +
Sbjct: 3675 MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATK 3734
Query: 2073 VSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVS 2132
+ + + ++ + L T L +D+ + S L++ RE R ++ + A L+ ++ +
Sbjct: 3735 IDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHM 3794
Query: 2133 QRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQ 2192
++ ++L +++ +L+K L A+ F L Q++ +L +P ++
Sbjct: 3795 EQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKA 3854
Query: 2193 QIQELNLEMEDQQENLDTLEHLVTELSSCGFA-LDLCQH---QDRVQNLRKDFTELQKTV 2248
Q+ + + Q+ + + E V + G A L+L Q +D++ L+ D+ +L
Sbjct: 3855 QLS----KYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIG 3910
Query: 2249 KEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI--PPTETSMSAKELEKQIEHLKSLL 2306
KE + + +++ ++ +KWL + G + P + S + + +Q+ H K+++
Sbjct: 3911 KEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMM 3970
Query: 2307 DDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLT 2366
++ A + + KG +L + + + L S ++
Sbjct: 3971 EEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI---------- 4020
Query: 2367 EIQCDMSDVNLKYEKLGGVLHE---RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKS 2423
S Y+ L L + RQ++LQ + V + Q S+ E +K
Sbjct: 4021 -----CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQ 4075
Query: 2424 MD---AMSSPTKT--ETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAE 2478
+ A+ +T + + + + + A ++ + IQ+ ++ + LV N +
Sbjct: 4076 VKHFRALQEQARTYLDLLCSMCDLSN---ASVKTTAKDIQQTEQTIEQKLVQAQNL--TQ 4130
Query: 2479 NWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGP 2538
W++I+ + W L+++ L + S+L
Sbjct: 4131 GWEEIKHLKSELW-----------IYLQDADQQLQNMKRRHSELE--------------- 4164
Query: 2539 LSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSI 2598
L+I NM++ QV+ +K+ ++++ + E + S KE+ +
Sbjct: 4165 LNIAQNMVS----QVKDFVKKLQSKQASVNTIIEKVNKL------TKKEESPEHKEINHL 4214
Query: 2599 NQKWVELTDKLNSRSSQIDQAIVKSTQYQE---LLQDLSEKVRAVGQRLSVQSAISTQPE 2655
N +W++L + N+ Q ++ + ++ Y + +++ EK L+ A E
Sbjct: 4215 NDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDA-----E 4269
Query: 2656 AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQ-- 2713
+ LE ++ L++ + +++ L D+ +I L D+ + +T L +
Sbjct: 4270 STAVHLEALKKLALALQERKYAIED---LKDQKQKMIEHLNLDDKELVKEQTSHLEQRWF 4326
Query: 2714 GLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQE 2773
LEDL +I L Q F EL W +++Q A+ S + Q+ L +
Sbjct: 4327 QLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMD 4386
Query: 2774 NEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQ 2833
+ L + ++ + + ++ + E++ +Q L + ++H LS R+
Sbjct: 4387 HLAICSELEAKQMLLKSLIKDADRVMADLGL-NERQVIQKALSDAQSHVNCLSDLVGQRR 4445
Query: 2834 SRLKDCMQKAQKYQWHVEDLVPWIEDCKAK-MSELRVTLDPVQLESSLLRSKAMLNEVEK 2892
L + + ++ V I+ + K M + L P + + K+
Sbjct: 4446 KYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKS------A 4499
Query: 2893 RRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS-LEEMTQRLR 2951
+ SL N + E ++ EK+ + + +ELQ+ S L++ + RL+
Sbjct: 4500 QASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKL----QELQSVYDSVLQKCSHRLQ 4555
Query: 2952 EFQESFKNIEKKVEGAKHQLEIFDALGSQACS-NKNLEKLRAQQEVLQALEPQVDYLRNF 3010
E +EK + KH E FD +AC K + + + L ++
Sbjct: 4556 E-------LEKNLVSRKHFKEDFD----KACHWLKQADIVTFPEINLMNESSELHTQLAK 4604
Query: 3011 TQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI-GQFHCRV--- 3066
Q ++E +P + LL + Q L V+ + KL + QF+ V
Sbjct: 4605 YQNILEQSP---EYENLLLTLQRTGQTILPSLNEVDHS--YLSEKLNALPRQFNVIVALA 4659
Query: 3067 REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA-----EC 3121
++ F ++ + ++ T S++E L ++K+ D+ EA C
Sbjct: 4660 KDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKV---PTDLAVEEALSLQDGC 4716
Query: 3122 RHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG---- 3177
R +L+E + GL ++ LN++ G+ Q L L Y +LK
Sbjct: 4717 RAILDE-----VAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHL---VTLYHRLKRQTEQ 4768
Query: 3178 ----LNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQG 3233
L D T+A +E E + + +++ + ++ + E+ P + KL+ + L G
Sbjct: 4769 RVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV----NEETLPAEEKLKMYHSLA-G 4823
Query: 3234 LIQSAG-----------------KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEAL 3276
+Q +G + H ++ L + + + + + +
Sbjct: 4824 SLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRM 4883
Query: 3277 LHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDM 3336
+ FQ + L WL + ++ + ++ +I++ ++ Q + ++
Sbjct: 4884 VQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNA 4943
Query: 3337 L-QAEGGRIAQSAEL--ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHE 3393
L E + ++ EL AD E +L L+ E L RQ L +I +++++
Sbjct: 4944 LSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL---RTRQATLTEIYSQCQRYYQ 5000
Query: 3394 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHK---ALEEDIENHATDVHQAVKIG 3450
+ +D+L ++L G ++ + H + E+ ++ ++H V
Sbjct: 5001 VFQAANDWLE-DAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLV--- 5056
Query: 3451 QSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNW 3510
+L L P + L +K+ SL+ R + + LL + + + + EV+
Sbjct: 5057 ATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIEL 5116
Query: 3511 LAEVEDKLSSV-FVKDFKQDVLHRQHADHLAL-------NEEIVNRKKNVDQAIKNGQAL 3562
+ + E KLS +K + ++H AL +E+IV ++ Q K G
Sbjct: 5117 MNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDA 5176
Query: 3563 LKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLRE 3622
K T + + + R+ + + + LE A T F + ++ T + +
Sbjct: 5177 SKATLSRSMTTVWQ-------RWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQ 5229
Query: 3623 VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLE--LVPWRAR 3680
++++L S + + ++ + E+ + + L + + + ++L+ P
Sbjct: 5230 LQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGE 5289
Query: 3681 E-GLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 3739
E L + ++ ++ + + + + ++ + E ++ WV ETK L
Sbjct: 5290 EPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKE---YL 5346
Query: 3740 GPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESL 3799
G +E D AQL+ + + H+ +++++ + E + T+L +
Sbjct: 5347 GNPTIEID---AQLEELQILLTEATNHRQNIEKMAEEQKEKY----LGLYTILPSELSLQ 5399
Query: 3800 IQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE-TRALIAQLPSPAIDHEQL 3858
+ + + + +++ V Q T +ELS I++ + L L + +
Sbjct: 5400 LAEVALDLKIRDQIQDKIKE----VEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNV 5455
Query: 3859 RQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEV 3918
Q + + + L E + + +L + E N + G+ + +K K ++ Q +
Sbjct: 5456 VQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQA 5515
Query: 3919 RQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKS 3978
R L++A S + E+++ +E +L+ +E + L + ++RE +++
Sbjct: 5516 ENRLSKLNQAAS---HLEEYNEMLELILKWIEK-AKVLAHGTIAWNSASQLREQYILHQT 5571
Query: 3979 ATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038
E +++ EA+ + + L +++ ++ ++ E+++ + R
Sbjct: 5572 LLEESKEIDSELEAMTEKLQYL-------TSVYCTEKMSQQVAELGRETEELRQMIKIRL 5624
Query: 4039 IKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDG 4098
D + +KF ++ L ++ Q L SP + +K+Q+ + + E +
Sbjct: 5625 QNLQDAAKDMKKFEAELKKLQAALEQAQ---ATLTSPEVGRLSLKEQLSHRQHLLSEMES 5681
Query: 4099 LHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAV 4158
L +++ +++ + L + + + L T ++ ++ A+
Sbjct: 5682 LKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYE 5741
Query: 4159 QYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF--KVEVYQQQIEMEKLN 4216
QY+ ++ + ++ ++ P +++ ++ Q++ +E K++ YQ+QI LN
Sbjct: 5742 QYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQI--ASLN 5799
Query: 4217 HQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEE 4276
+ +++ KA T + +TE+ E +A L+G LL ++
Sbjct: 5800 SKCKMLTMKAKHAT----MLLTVTEV--------EGLAEGTEDLDGELLPTPSAHPSVVM 5847
Query: 4277 LMSWLTHT----------EELLDAQ----------RPISGDPKVIEVELAKHHVLKNDVL 4316
+ + HT EE +++ P++ + ++A + L + L
Sbjct: 5848 MTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERL 5907
Query: 4317 -AHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQ 4375
A + A E E A+ ++L + + WE++ E+++ L L++
Sbjct: 5908 QTDAAKIHPSTSASQEFYEPGLEPSAT---AKLGDLQRSWETLKNVISEKQRTLYEALER 5964
Query: 4376 AQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLL 4435
Q + ++ ++ +E +LS S G PE+ Q+ H L ++ ++ N+L
Sbjct: 5965 QQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMDEILMLQDEINELQ 6021
Query: 4436 DKGRLMLLSRD---DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS 4492
L+S D + ++ +L ++ + K ++ LEE LN E Q
Sbjct: 6022 SSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQ 6081
Query: 4493 LQ----------EFINWLTLAEQSLNIA-SPPS---------LILNTVLSQIEEHKVFAN 4532
Q E +WL + +L+ A SPP + +L +IE+ V +
Sbjct: 6082 EQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALS 6141
Query: 4533 EVNAHRDQII---------ELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIE 4583
E++ H + ++ E +Q +L+ L K ++ ++ L Q + Q E
Sbjct: 6142 ELSVHNENLLLEGKAHTKDEAEQLAGKLRRL--KGSLLELQRALHDKQLNMQGTAQEKEE 6199
Query: 4584 RGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL----DSELEISNDPDKIKLQLSKHKEF 4639
L + Q A + W + +S L + E E++ ++ S+ +E
Sbjct: 6200 SDVDLTATQSPGVQEWLAQAR-TTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEI 6258
Query: 4640 QKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLE 4699
+ D + +E + E S D ++R KW+++ + +Q L+
Sbjct: 6259 LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED----QMRMKWESLHQEFSTKQKLLQ 6314
Query: 4700 EALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDA-HKVFQKELGKRTG 4758
L + L + + L P D P D V +L+D ++ F++ + G
Sbjct: 6315 NVL--EQEQEQVLYSRPNRLLSGVPLYKGDVPTQ-DKSAVTSLLDGLNQAFEEVSSQSGG 6371
Query: 4759 TVQVLKRSGRELIENSRDDTTWV 4781
+ ++L + +TW+
Sbjct: 6372 AKRQSIHLEQKLYDGVSATSTWL 6394
Score = 261 bits (667), Expect = 1e-68
Identities = 849/4732 (17%), Positives = 1780/4732 (37%), Gaps = 683/4732 (14%)
Query: 648 QNFHTSYAETLGKLETQYCKLKETSSFRMRHLQS--LHKFVSRATAELIWLNEKEEEELA 705
+N T ETL L+++ L E SS Q L K S A + L+E E+ +
Sbjct: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEK--ML 1228
Query: 706 YDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDT-----AELLSLENHPAKQTVEAY 760
++ D +N EL +E Q+ + DT A+ L L + + + A
Sbjct: 1229 SNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAK 1288
Query: 761 SAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTS 820
VQ Q+ +Q E + + R+LES L L+ S +R+
Sbjct: 1289 KRDVQQQIAQAQQ---------GEGGLPDRGHEELRKLESTLDGLERSRERQ-------- 1331
Query: 821 LSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYR 880
E +Q ++ + E+ +K +V + ++ + S + L + S++++
Sbjct: 1332 ----ERRIQVTLRKWERFETNKETVVRYLFQTGS-------SHERFLSFS-SLESLSSEL 1379
Query: 881 QIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSY 940
+ K E + K P G P NK ++ ++ +
Sbjct: 1380 EQTKEFSKRTESIAVQAENLVKEASEIPLG-------------PQNKQLLQQQAKSIKEQ 1426
Query: 941 QKVMALWHQLHVNTKSLIS--WNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYE 998
K + + + T ++ W++ + + + W EK + E ++Q
Sbjct: 1427 VKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQI 1486
Query: 999 DFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRL 1058
+S L S+ LEEE ++ F + + E+ K +++++
Sbjct: 1487 KVTIQEIESKLSSIVG---LEEEAQS----FAQFVTTGESAR-----IKAKLTQIRRYGE 1534
Query: 1059 RLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF 1118
L E+ Q + I +++Q+ +E+L++++ + K
Sbjct: 1535 ELREHAQCLEGTILG----------------HLSQQQKFEENLRKIQQSVSEFEDKLAVP 1578
Query: 1119 LHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEI 1178
+ S++ + E L + ++ + T + + V +Q+A L + YE
Sbjct: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYED 1638
Query: 1179 KLSQEEVVLADLSALEAHWSTLRHWLSD-------------------------VKDKNSV 1213
L + + L L AHW L LS V+ + +
Sbjct: 1639 ILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQL 1698
Query: 1214 FSVLDEEIAK-----AKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQS 1268
L E+ +K++ + S + D++ + QL ERW + +I
Sbjct: 1699 IQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLP---QIINK 1755
Query: 1269 ELESIQEVLGDYRACHGTLIK---WIE------ETTAQQEMMK-----------PGQAED 1308
+ +Q V+ +++ L+ WI+ +TT++ +M + E
Sbjct: 1756 RINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1815
Query: 1309 SRVLSEQLSQQTALFAEIERN------QTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVE 1362
+ + L A + R Q K + C + ++ S +V+ +L L F++
Sbjct: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQ 1875
Query: 1363 SQQKSPGKRRRMLSS-----------SDAITQEFMDLRTRYTALVTLTTQHVKYISDALR 1411
S G R++ + SD I ++ D AL + +S A
Sbjct: 1876 SHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQY 1935
Query: 1412 RLE----EEE---KVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAI 1464
L+ E+ + ++ VE+++ LLG + ++ A + K D ++ +
Sbjct: 1936 HLKIGSSEQRTSCRATADQLCGEVERIQNLLG-----TKQSEADALAVLKKAFQDQKEEL 1990
Query: 1465 LEQQVLSEELTTK---KEQVSEAIKTS-QIF------LAKHGHKL---SEKEKK------ 1505
L+ EE T K KE +A++ ++F L H H+L +K K+
Sbjct: 1991 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDV 2050
Query: 1506 ----QISEQLNALNKAYHDL----------CDGSAN---QLQQLQSQLAHQTEQKTLQKQ 1548
++ ++N L + D C G + + Q L+S ++ E +
Sbjct: 2051 AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIV 2110
Query: 1549 QNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL-----------SALQK-NQSDLKDLQ 1596
T + EDL W ++ A ++ Q+DL S L+K + SD ++
Sbjct: 2111 TRTTIKDQEDL-KWAF-SKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2168
Query: 1597 DDIQNRATSFATVVKDIEGFMEENQTKLSP-RELTALREKLH--------QAKEQYEALQ 1647
D+++ + V + +E M+ + LS ++ + R+++ Q E L
Sbjct: 2169 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2228
Query: 1648 EETRVAQ--KELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTN 1705
R + KE E V + + E +L E K ++ D + + + Q L +
Sbjct: 2229 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD-LQFIEADLMQKLEH 2287
Query: 1706 LPGMEQLSGASLEKGALDTTDGYMGVN-------QAPEKL-----DKQCEMMKAR---HQ 1750
+ +++ +L+ +T +N + E L ++ CE +K +
Sbjct: 2288 AKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2347
Query: 1751 ELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQV 1810
EL SQQ N I +TQ L + H+ E + + + G +K+ + S S+ +
Sbjct: 2348 ELQSQQSN-ISSTQENLNSLCRKYHSA--ELESLGRAMTGLIKKHEAVSQLCSKTQA--- 2401
Query: 1811 QTLQDELQK-FLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHK 1869
+LQ+ L+K F + +EF+ W ++ + + L + L + + V +
Sbjct: 2402 -SLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2460
Query: 1870 GDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNM 1929
L VT GQ + +I + +++++ A E + A +C + L
Sbjct: 2461 SKLDAVTQEGQTLY--------AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQD 2512
Query: 1930 LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQV 1989
+ F++ L W+ E E+ ++ + + E+ +++ L E
Sbjct: 2513 CASELGSFEDQHRKLNLWIHEME---ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLA 2569
Query: 1990 PVEKLQKVAR--DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQS 2047
E L K+++ ++ EG A + +L+ Q+L E+ Q A+ +
Sbjct: 2570 ARESLDKLSQRGQLLSEEGHGAGQEGRL---CSQLLTSHQNLLRMTKEKLRSCQVALQEH 2626
Query: 2048 QSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATRE 2107
++++E+L+S+ + ++ L + S+L S ++ L + QDI K E
Sbjct: 2627 EALEEALQSMWFWVKAIQDRLACAE-STLGS---KDTLEKRLSQIQDILLMKGEGEVKLN 2682
Query: 2108 MVT----RFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLS 2163
M + + +++ V+Q +L + + + + +S+L+ ++ Q +
Sbjct: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
Query: 2164 GKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGF 2223
+L+Q+ME+ DQ I H Q L +E L+HL + LS
Sbjct: 2743 NQLEQWMESV----------DQKIEHPLQPQPGL-------KEKFVLLDHLQSILSEAE- 2784
Query: 2224 ALDLCQHQDRVQNLRKDFTEL-QKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGS 2282
H + L EL +KT E KD + +E +F ++ ++ +++ E
Sbjct: 2785 -----DHTRALHRLIAKSRELYEKTEDESFKDTAQ-EELKTQFNDIMTVAKEKMRKVEEI 2838
Query: 2283 IPPTETSMSA-KELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGK 2341
+ + A E + K L W+ K + ++ LI DS+
Sbjct: 2839 VKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELI------DSREI 2892
Query: 2342 TGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRME 2401
S L V S V ++ T C++ +H ++L+A
Sbjct: 2893 GASRLSRVESLAPEVK-----QNTTASGCEL-------------MHTEMQALRA------ 2928
Query: 2402 EVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVK 2461
W + ++ V ++ + + V A S + F ++ Q +++
Sbjct: 2929 ----------DWKQWEDSVFQTQSCLEN-----LVSQMALSEQEFSGQVAQ----LEQAL 2969
Query: 2462 EALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR---QLEESASHLACFQAA 2518
E + LL T+ K EE+ W + E+ A Q+ + E+ S L
Sbjct: 2970 EQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQL------ 3023
Query: 2519 ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ-----KQQVQFMLKEFEARRQQHEQLNEA 2573
++L + + G + L + N L Q + + Q + + F + +Q
Sbjct: 3024 -NELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVN 3082
Query: 2574 AQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDL 2633
A+ D+ + S+V LQ I E + + +++ + K ELL L
Sbjct: 3083 AKITTAKCFDIPQNISEVSTSLQKIQ----EFLSESENGQHKLNMMLSKG----ELLSTL 3134
Query: 2634 SEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIG 2693
K +A G +Q+ ++ E K + S LE L ++K+ + +
Sbjct: 3135 LTKEKAKG----IQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFE---------VS 3181
Query: 2694 EQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ 2753
+ ++D L K + V L DL A R + Q+ Q + +E+ +
Sbjct: 3182 AEPIQDWLSKTEKMVHESSNRLYDLPAKRREQ--------QKLQSVLEEIHCY------- 3226
Query: 2754 QAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQN 2813
+L RL+ + Q+ E Q + ++ ++
Sbjct: 3227 -------EPQLNRLKEKAQQLWEGQAA---------------------------SKSFRH 3252
Query: 2814 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM-SELRVTLD 2872
++ +L + + LS T ++ SRL + + ++ +++L W+ D + S T D
Sbjct: 3253 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3312
Query: 2873 PVQLESSLLRSKAMLN-EVEKRRSLLEILNSAADILINSS-------EADEDGIRDEKAG 2924
L+S L+ +A+L+ + EK + I+ +L N+S + ++D A
Sbjct: 3313 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWAS 3372
Query: 2925 INQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKV-EGAKHQLEIFDALGSQACS 2983
+ +L+ +R+F ++E + E + E+ D +
Sbjct: 3373 LLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKA 3432
Query: 2984 NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQ 3043
E++ + +L+ +E + G+ E + L Q+ + +++
Sbjct: 3433 KLLNEEVLSYSSLLETIEVK-------GAGMTEHYVTQLELQDL-------QERYRAIQE 3478
Query: 3044 RVNSGCVMMENKLEGIGQFHCRVREMFSQ-LADLDDELDGMGAIGRDTDSLQSQIEDVRL 3102
R E KL + Q + R + F L ++LD + D + ++ + D++
Sbjct: 3479 RAKEAVTKSE-KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQ- 3536
Query: 3103 FLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLK----RELEALNKQCGKLTERGKARQ 3158
L++ +A +L + G+ R LE+L + R +
Sbjct: 3537 ------ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
Query: 3159 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3218
Q + ++ +K + +++ AEE + + + QL K + E+V
Sbjct: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWH-EEVT 3649
Query: 3219 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3278
+ ++++V Q ++ + + + ++ +R+ L +V ++I L+E +
Sbjct: 3650 AYRDEVEEVGARAQEILDESHVN---SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQS 3706
Query: 3279 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL--LQRLLDDRKATVDM 3336
+ + +L W T + N K + + V + +KL L+ LL D + +
Sbjct: 3707 LEESESSLSSYSDWYGSTHK---NFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSL 3763
Query: 3337 LQA---EGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHE 3393
L++ +G R + E + E++ ++ + EL S LE L LAK+F +
Sbjct: 3764 LKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSD 3823
Query: 3394 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3453
+ ++ +++ ++ L E + + + Q+ ++K+L++ + +H V + G++L
Sbjct: 3824 KCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEAL 3883
Query: 3454 SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAE 3513
L L +KID LQ+ Y ++ L+ + + + + EV WL +
Sbjct: 3884 LELVQDV---TLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
Query: 3514 VEDKLSSV-FVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVL 3572
+ +L + ++ + + +Q A H A+ EEI + ++ G L+ Q
Sbjct: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA 4000
Query: 3573 LIQEK----LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA 3628
+++ L G K Y+ I T+ + ++LE Q Q T ++ WL V+ +L
Sbjct: 4001 KLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLE 4060
Query: 3629 TSGGQSPTG-----EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 3683
S Q P +Q+ F+ Q++ + + + D N + + + +
Sbjct: 4061 PSP-QPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIE 4119
Query: 3684 DKLVSDAN-----EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA--WVAETKRKL 3736
KLV N E+ K + + + + D +Q ++ + +A V++ K +
Sbjct: 4120 QKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFV 4179
Query: 3737 MALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKT 3796
+L+ Q + ++K + E+ + C + LQ +
Sbjct: 4180 K-----KLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQRE- 4233
Query: 3797 ESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRAL-IAQLPSPAIDH 3855
E L + + +N +V + +F ++ L+ E+ A+ + L A+
Sbjct: 4234 EDLQRTRDYHDCMNV--------VEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALAL 4285
Query: 3856 EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK 3915
++ + E+++ ++ + EH LN ++ E+V+E+ E + Q++
Sbjct: 4286 QERKYAIEDLKDQKQKMIEH----------------LNLDDKELVKEQTSHLEQRWFQLE 4329
Query: 3916 EEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE----NLSSRLRMPPLIPAEVDKIRE 3971
+ ++++ + +V+ ++ + + ++E E N++ L+ P D +
Sbjct: 4330 DLIKRK---IQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSP----PPDMAQN 4382
Query: 3972 CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIK 4031
+ D+ + ELE Q ++L + + ++ ++ + K + D + + +
Sbjct: 4383 LLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVG 4442
Query: 4032 ARAEEREIKFLDVLELAEKFWYDMAALLTT--IKDTQDIVHDLESPGIDPSIIKQQVEAA 4089
R K+L+ L+EK + MA T I+ + + E + P + +QV+
Sbjct: 4443 QRR-----KYLNKA-LSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC 4496
Query: 4090 ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEK 4149
++ + E+ + G +L+ E EK EV + E+ + ++++ + RL++
Sbjct: 4497 KSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQE 4556
Query: 4150 LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQ 4209
LE + + +++ WL I T P + +N + ++ +++ + +Q
Sbjct: 4557 LEKNLVSRKHFKEDFDKACHWLKQADI--VTFPEINL-MNESSELHTQLAKYQ-NILEQS 4612
Query: 4210 IEMEKL----NHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL 4265
E E L G+ +L + +E D + E L L + + + +K++ A+L
Sbjct: 4613 PEYENLLLTLQRTGQTILP-SLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAIL 4671
Query: 4266 ALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETV 4325
A ++ +E LT T+ L + +E + + + D+ +A ++
Sbjct: 4672 ARKEYASLIE-----LT-TQSLSE-----------LEAQFLRMSKVPTDLAVEEAL--SL 4712
Query: 4326 NKAGNELLESSAG-----DDASSLRSRLEAMNQCWE--------SVLQKTEEREQQLQST 4372
+L+ AG D+ + + + Q W+ ++ + + + +Q S
Sbjct: 4713 QDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSL 4772
Query: 4373 LQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYN 4432
L+ + E E +L R QL + K + +++Y L +
Sbjct: 4773 LEDTTSAYQEHEKMCQQLER---QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSG 4829
Query: 4433 QLLDKGRLML---LSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEF 4489
+L + + L D + K + + + +++S + E ++ E + + +F
Sbjct: 4830 IVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDF 4889
Query: 4490 QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 4549
Q + ++WL + L+ L L + +I + ++ EV + + L
Sbjct: 4890 QTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEK 4949
Query: 4550 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIE-RGRSLDDARKRAKQFHEAWKKLIDW 4608
+ KF K+ + ++ S + +Q ++ R +L + + +++++ ++ DW
Sbjct: 4950 E-KFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDW 5008
Query: 4609 LEDA----------------ESHLDSELEISNDPDKIKLQLSKHKEFQKTLG------GK 4646
LEDA E +L S +E + D+ L + TL GK
Sbjct: 5009 LEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGK 5068
Query: 4647 ----QPVYDTTIRTGRALKEK----------TLLPEDSQK----LDNFLGEVRDKWDTVC 4688
Q V +R+ R ++ T D QK + + + K
Sbjct: 5069 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFS 5128
Query: 4689 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 4748
H+ EE L + + + + + +E + ++ + D V
Sbjct: 5129 LLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTV 5188
Query: 4749 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVC-KLSVSKQSRLE 4807
+Q R ++ + + +++E++ D+ T ++++ + D + KL S +
Sbjct: 5189 WQ-----RWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5243
Query: 4808 QA-LKQAEVFRDTVHMLLEWLSEA-----EQTLRFR--GALPDDTEA--LQSLIDTHKEF 4857
+A L + DT + LE A +QTL GA P E L I ++
Sbjct: 5244 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5303
Query: 4858 MKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWI----------TI-IRARFEEV-- 4904
++EK V N + E+ I ++K W+ TI I A+ EE+
Sbjct: 5304 CLNMQEK-VKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQI 5362
Query: 4905 -LTWAKQHQQRLETALSELVANAELLEELLAW---IQWAETTLIQRDQEPIPQNIDRVKA 4960
LT A H+Q +E E L +L +Q AE L + ++ I I V+
Sbjct: 5363 LLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQ 5422
Query: 4961 LIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEK----SRSGGRKSLSQPTPP 5016
A Q ++ + D+ + K K A +K G L +
Sbjct: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
Query: 5017 PMPILSQS----EAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064
L Q+ + +I +L+ QQ A R KLN A LEE E
Sbjct: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNE 5534
Score = 235 bits (599), Expect = 1e-60
Identities = 570/3191 (17%), Positives = 1235/3191 (38%), Gaps = 398/3191 (12%)
Query: 2041 QKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVI----QEALATNMKLKQDIA 2096
Q+ + + +++ + S S+G++ + + + + SS + QE LA K+ +
Sbjct: 811 QQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLT 870
Query: 2097 RQKSSLEATREMVT--RFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP 2154
+ ++ ++ VT ++ D T LQ ++A++ F+ + + + + ++
Sbjct: 871 LIEKGSQSVQKFVTLSNVLKHFDQTR---LQRQIADIHVAFQSMVKKTGDWKKHVETNSR 927
Query: 2155 QAEMFEHLSGKLQQFMENKSRMLASGNQPDQDI---THFFQQIQELNLEMEDQQENLDTL 2211
+ FE +L++ + L P++ + T FF Q+ + L + D L
Sbjct: 928 LMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAF--LKACDEL 985
Query: 2212 EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQ----------KTVKEREKDASS---C 2258
++ E G Q+ V+ L K + +LQ K E+ + +S C
Sbjct: 986 TDILPEQEQQGL-------QEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEEC 1038
Query: 2259 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2318
+ +LD KL+ P E S EK I+ + D +
Sbjct: 1039 RTELDRETKLM---------------PQEGS------EKIIKEHRVFFSDKGPHHLCEKR 1077
Query: 2319 INCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK 2378
+ L + D+ G L + +++ S T + L E D +
Sbjct: 1078 LQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDS-----TYRKLMEDPDKWKDYTSR 1132
Query: 2379 YEKLGGVLHERQESLQAILNR-------------MEEVHK---EANSVLQWLESKEEVLK 2422
+ + + + L+ I +EE+ + L WL+S+ +VL
Sbjct: 1133 FSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLT 1192
Query: 2423 SMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKK 2482
+ + + K A+ S+ L L + +V++ L+ N + +K+
Sbjct: 1193 EVSSENEAQKQGDELAKLSSSFKALVTL------LSEVEKMLS-------NFGDCVQYKE 1239
Query: 2483 IQEELNSRWERATEVTVARQRQLEESASHLA----CFQAAESQLRPWLMEKELMMGVLGP 2538
I + + E ++ ++++E A + F+A + L K
Sbjct: 1240 IVKN-------SLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKR-------- 1284
Query: 2539 LSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSI 2598
I + Q+Q Q E + HE+L + + L G + S + ++ +Q
Sbjct: 1285 --ISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKL-ESTLDG---LERSRERQERRIQVT 1338
Query: 2599 NQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVK 2658
+KW K T + L Q S R + S ++S++ E K
Sbjct: 1339 LRKWERFETN-------------KETVVRYLFQTGSSHERFLS--FSSLESLSSELEQTK 1383
Query: 2659 QQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDL 2718
+ + T I E L VKEA + +G Q K L+++ +++ ++ LED
Sbjct: 1384 EFSKRTESIAVQAENL---VKEAS------EIPLGPQN-KQLLQQQAKSIKEQVKKLEDT 1433
Query: 2719 AADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQEN-EEF 2777
+ I ++ F F+ L W+ +K+ + S+ ++ SQ++ +E
Sbjct: 1434 LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI 1493
Query: 2778 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 2837
+ L+ G E E +S V GE R ++ +L +++ + EEL + + +
Sbjct: 1494 ESKLSSIVGLEE----EAQSFAQFVTTGESAR-IKAKLTQIRRYGEELREHAQCLEGTIL 1548
Query: 2838 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLL 2897
+ + QK++ ++ + + + + K++ P+++ SS + +L E L
Sbjct: 1549 GHLSQQQKFEENLRKIQQSVSEFEDKLAV------PIKICSSATETYKVLQEHMDLCQAL 1602
Query: 2898 EILNSAADILINSSE--ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQE 2955
E L+SA S+ + D E A + Q + + + + +LE +
Sbjct: 1603 ESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAH------ 1656
Query: 2956 SFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEV--LQALEPQVDYLRNFTQG 3013
++ +EK++ LE +A S + + ++++ + E+ +QAL+ +V +F
Sbjct: 1657 -WQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSK 1715
Query: 3014 LVE------DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVR 3067
L++ D + E + + ++ Q +N +++ + QF +
Sbjct: 1716 LLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLL 1775
Query: 3068 EMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE 3127
+ EL + T + V L +K H ++E+ + E + +
Sbjct: 1776 SFSVWIKLFLSEL-------QTTSEISIMDHQVALTRHKDHAA--EVESKKGELQSLQGH 1826
Query: 3128 EGTLDLLGLKRELEALN---KQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTA 3184
L LG +L L + C +L E E+ +L L + +F + L+
Sbjct: 1827 LAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQ 1886
Query: 3185 AEEA-EALQWVVGTEVEIINQQLADFKMFQKE------QVDPLQMKLQQVNGLGQGLIQS 3237
+ EA + E ++I + L D K +D + K Q +G ++
Sbjct: 1887 LRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRT 1946
Query: 3238 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3297
+ + Q L ++E I T + A +A L++A FQD E LL + D E
Sbjct: 1947 SCRATADQ-LCGEVERIQNLLGTKQSE-ADALAVLKKA------FQDQKEELLKSIEDIE 1998
Query: 3298 ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKIT 3357
E ++ + ++ +++ L+ L+ + + L+ + +IAQ ++A ++
Sbjct: 1999 ERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK-DVAFAPEVD 2057
Query: 3358 GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLS------VTEKKLAN 3411
++ LE W + Q Q ++ L +++ +S L VT + +
Sbjct: 2058 REINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKD 2117
Query: 3412 SEPVGTQTAKIQQQIIRHKALEEDIENHATD----VHQAVKIGQSLSSLTSPAEQGVLSE 3467
E + +K + + ++D++N + + + KI S SL + + +
Sbjct: 2118 QEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDK 2177
Query: 3468 KIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVL--NWLAEVEDKLSSV---- 3521
+D + + E DR ++ D LS DE+E N + ++ + +S++
Sbjct: 2178 WLD-VSEKLEENMDRLRVSLSIWDDVLST-----RDEIEGWSNNCVPQMAENISNLDNHL 2231
Query: 3522 ----FVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK 3577
+K+F+ +V ++ L L EE+ ++ ++ + KN + T ++ I+
Sbjct: 2232 RAEELLKEFESEVKNKA----LRL-EELHSKVNDLKELTKNLE------TPPDLQFIEAD 2280
Query: 3578 LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTG 3637
L +IT A TL+ +T+ + ++T W +VEE L Q+ T
Sbjct: 2281 LMQKLEHAKEITEV---AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCA-QNETC 2336
Query: 3638 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLV 3697
E + + + QKEL+ + + +N + R E L + ++ ++++ V
Sbjct: 2337 EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSA----ELESLGRAMTGLIKKHEAV 2392
Query: 3698 SDTIGQRVDEIDAAIQRS--QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQV 3755
S Q + A++Q S + + ++ W K E T +V
Sbjct: 2393 S----QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK-------ESSDRTGDSKV 2441
Query: 3756 QKAFSIDIIRHKDSMDE--------------LFSHRSEIFGTCGEEQKTVLQEKTESLIQ 3801
+A D+ DS+ + L++H S+ + +EQ T E+ ++ ++
Sbjct: 2442 LEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLK 2501
Query: 3802 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQ 3861
Q ++ A + A L F + + +L+ WI E + + + ++
Sbjct: 2502 Q------CLKDKQALQDCASEL-GSFEDQHRKLNLWIHEMEERF-NTENLGESKQHIPEK 2553
Query: 3862 QEEMRQLRESIAE---HKPHIDKLLKIGPQLKELNP---EEGEMVEEKYQKAENMYAQIK 3915
+ E+ ++ + E + +DKL + G L E +EG + + +N+ K
Sbjct: 2554 KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTK 2613
Query: 3916 EEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISD 3975
E++R +AL E + + ++ + + L S L + + +I++ +
Sbjct: 2614 EKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLM 2673
Query: 3976 NKSATVELEK-LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARA 4034
V+L + +AL+ +E + IQ +L+ + W DI + +
Sbjct: 2674 KGEGEVKLNMAIGKGEQALRSSNKE------------GQRVIQTQLETLKEVWADIMSSS 2721
Query: 4035 EEREIKFLDVLELAEKFWYDMAALLTTIKD-----TQDIVHDLE-SPGIDPSIIKQQVEA 4088
+ LE W D ++ Q I H L+ PG+ + ++
Sbjct: 2722 VHAQ----STLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVL--LDH 2775
Query: 4089 AETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI-DEMNNAWENLNKTWKERL 4147
++I E + L + +L +TE + + +E+ + ++ KE++
Sbjct: 2776 LQSILSEAEDHTRALHRLIAKSRELY---EKTEDESFKDTAQEELKTQFNDIMTVAKEKM 2832
Query: 4148 EKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQ 4207
K+E+ ++ + Y D + DWL + +L + D + + +L+++KE +
Sbjct: 2833 RKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKEL---IDS 2889
Query: 4208 QQIEMEKLNHQGELM--LKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL 4265
++I +L+ L +K+ T + +++ + L+ W+ + + Q LE +
Sbjct: 2890 REIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVS 2949
Query: 4266 ALG-----------QFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKND 4314
+ Q + ALE+ + L + L + D +++E +L
Sbjct: 2950 QMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDAL 3009
Query: 4315 VLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQ 4374
A T E + NEL S D S+ ++ + + + + + + Q + LQ
Sbjct: 3010 QKAEPRT-EDLKSQLNELCRFSR--DLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ 3066
Query: 4375 QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETARE---QLDTHMELYSQLKAKEETY 4431
Q F DF L + ++++ +K +P+ E L E S+ + +
Sbjct: 3067 QR--FRKAFRDFQQWL--VNAKITTAK-CFDIPQNISEVSTSLQKIQEFLSESENGQHKL 3121
Query: 4432 NQLLDKGRLM--LLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEF 4489
N +L KG L+ LL+++ + + V ++ W S + +++S LE +F
Sbjct: 3122 NMMLSKGELLSTLLTKEKAKG---IQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDF 3178
Query: 4490 QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 4549
+ S + +WL+ E+ ++ +S L + ++ + E++ + Q+ L +
Sbjct: 3179 EVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQ 3238
Query: 4550 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWL 4609
QL + ++ + + S++ + + E+ LD QF K+L DW+
Sbjct: 3239 QL--WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWM 3296
Query: 4610 EDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPED 4669
DA LDS ++D + + K + K+ + G ++ + T PE
Sbjct: 3297 TDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS-PEG 3355
Query: 4670 SQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAED 4729
+ L V+D W ++ + + +LE AL + D ++ W+ +E L E
Sbjct: 3356 IPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNES 3415
Query: 4730 QPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELS 4789
+ H +L ++ K+ +E+ + ++ ++ G + E+ +LQ+L
Sbjct: 3416 ERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQL-----ELQDLQ 3470
Query: 4790 TRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQS 4849
R+ + + + ++ E+ ++ + ++ + WL + ++ L D L+
Sbjct: 3471 ERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKL-------DQYSVLEG 3523
Query: 4850 LIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAK 4909
TH+ ++ ++E +V A G+ +L +++ R + + +
Sbjct: 3524 DAHTHETTLRDLQELQVHC----AEGQALLN--------------SVLHTREDVIPSGIP 3565
Query: 4910 QHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFM 4969
Q + R AL L + + + L+ + ++ + + Q +V + + +
Sbjct: 3566 QAEDR---ALESLRQDWQAYQHRLSETRTQFNNVVNK-LRLMEQKFQQVDEWLKTAEEKV 3621
Query: 4970 EEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNP 5029
TR+Q + R TK + ++ H + + R + + IL +S +
Sbjct: 3622 SPRTRRQSN--RATKEIQLHQMKKWH-----EEVTAYRDEVEEVGARAQEILDESHVNSR 3674
Query: 5030 ---RINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKS 5086
+ QL++R+Q + L LE+ + L + + LEE + + Y W
Sbjct: 3675 MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLS--------SYSDWYGSTHK 3726
Query: 5087 RVMDFFRRIDK 5097
+ +IDK
Sbjct: 3727 NFKNVATKIDK 3737
Score = 223 bits (568), Expect = 4e-57
Identities = 733/3955 (18%), Positives = 1495/3955 (37%), Gaps = 630/3955 (15%)
Query: 400 DVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAA 459
D++EE K+ I E + SLR I N + + +EK T AK + AD
Sbjct: 4919 DIQEEIRKIQIHQEEVQSSLR-----------IMNALSHKE---KEKFTKAKELISADLE 4964
Query: 460 HLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTL 519
H + + + D+ ++ + + ++ Q YYQ+ + A + EL+ L
Sbjct: 4965 H-SLAELSELDGDIQEALRTRQATLTEIYSQCQ-----RYYQVFQAANDWLEDAQELLQL 5018
Query: 520 R-----LECTNLYRKGH--FTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRA 572
+E K H F S E S L H L + + +
Sbjct: 5019 AGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASL 5078
Query: 573 ELVAISSSEDEGNLRFVYELLS--WVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE 630
EL + S D G + + + W + + + E E ND E +L + TS
Sbjct: 5079 ELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMND---TEKKLSEFSLLKTS-- 5133
Query: 631 ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSS----------------- 673
S E +L E K + S+ E + LE + +L++T +
Sbjct: 5134 --SSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQR 5191
Query: 674 -FRMRHL-QSLHKFVSRATAELIWLNEKEEE--ELAYDWSDNNSNISAKR---------- 719
R+R + Q K + A E N K ++ E+ D SA++
Sbjct: 5192 WTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLL 5251
Query: 720 NYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVE 779
Y +ELE++Q L+ + LS+ A T +Q ++ M+ CL ++
Sbjct: 5252 EYHDTFVLELEQQQSALGMLRQ--QTLSMLQDGAAPTPGEEPPLMQ-EITAMQDRCLNMQ 5308
Query: 780 QHVKENTAYF-QFFSDARELESFLRNLQDSIK--RKY----SCDHNTSLSRLEDLLQDSM 832
+ VK N Q D +E+ + +++ ++ ++Y + + + L L+ LL ++
Sbjct: 5309 EKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEAT 5368
Query: 833 DEKEQLI----QSKSSVASL-------------------------------VGRSKTIVQ 857
+ ++ + + K L V +SK Q
Sbjct: 5369 NHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQ 5428
Query: 858 LKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVIS-PTGNEAMVP 916
R + K+ ++ + + K D+ VL + K++ + +
Sbjct: 5429 ELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLE 5488
Query: 917 SVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLE 976
L P K ++ +Q+ ++ +L+ L +N + L+L+ W +E
Sbjct: 5489 QNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEM---LELILKW-IE 5544
Query: 977 KLRSSAPG-----ECHQIMKNLQAHYEDFLQDSR--DSVLFSVADRLRLEEEVEACKARF 1029
K + A G Q+ + H + L++S+ DS L ++ ++L+ V +
Sbjct: 5545 KAKVLAHGTIAWNSASQLREQYILH-QTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMS 5603
Query: 1030 QHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNAL 1089
Q + + ++ + K+ + L++ ++++E + K +L ++ + + L
Sbjct: 5604 QQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRL 5663
Query: 1090 RIAEQ----EHTQEDLQQLRSDLDAVSMKCDSFLH------------------QSPSSSS 1127
+ EQ +H +++ L+ + AV + C S L Q +S
Sbjct: 5664 SLKEQLSHRQHLLSEMESLKPKVQAVQL-CQSALRIPEDVVASLPLCHAALRLQEEASRL 5722
Query: 1128 VPTLRSELNLLV----------EKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYE 1177
T + N++ ++M H+ L +++ V +IQ+ + + +E
Sbjct: 5723 QHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHE 5782
Query: 1178 -----IKLSQEEVVLAD----LSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVA 1228
IK QE++ + + ++A +T+ +++V+ LD E+
Sbjct: 5783 ELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAH 5842
Query: 1229 EQMSRLTPERNLDL-----ERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRAC 1283
+ +T R L E E+G+ + + S+ + + Y+A
Sbjct: 5843 PSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQAL 5902
Query: 1284 HGTLI-----KWIEETTAQQEMMKPGQAEDS---------------RVLSEQLSQQTALF 1323
+ K T+A QE +PG + V+SE+ Q L+
Sbjct: 5903 SAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEK---QRTLY 5959
Query: 1324 AEIERNQTKLDQCQKFSQQYSTIV----------KDYELQLMTYKAFVE---------SQ 1364
+ER Q D Q S + I + E Q+ ++A ++ ++
Sbjct: 5960 EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINE 6019
Query: 1365 QKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEE------EEK 1418
+S + S +A E + L++ T L + S + LEE EE+
Sbjct: 6020 LQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQ 6079
Query: 1419 VVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKK 1478
E+ Q + + EL W+ L+ S KE D+E +++ Q + E+ K
Sbjct: 6080 RQEQALQRYRCEADELDSWL--LSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKV 6137
Query: 1479 EQVSE-AIKTSQIFLAKHGHKLSEKEK-----KQISEQLNALNKAYHDL----------- 1521
+SE ++ + L H E E+ +++ L L +A HD
Sbjct: 6138 VALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK 6197
Query: 1522 ----CDGSANQLQQLQSQLAH------QTEQKTLQKQQNTCHQQLED----LCSWVGQAE 1567
D +A Q +Q LA Q Q +LQ QQ Q+L + L S + E
Sbjct: 6198 EESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQ-QQKELEQELAEQKSLLRSVASRGE 6256
Query: 1568 RALAGHQGRTTQQD-------LSALQKNQSDLKDLQDDIQNRATS----FATVVKDIEGF 1616
L H T D LS + + +D ++ + S F+T K ++
Sbjct: 6257 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 6316
Query: 1617 MEENQTKL---SPREL-------------------TALREKLHQAKEQYE-----ALQEE 1649
+E+ Q ++ P L T+L + L+QA E+ A ++
Sbjct: 6317 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 6376
Query: 1650 TRVAQK-------------ELEEAV---TSALQQETE-----KSKAAKELAENKKKIDAL 1688
+ QK ++EE + T+ L +ETE + AK++ E +++D
Sbjct: 6377 IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 6436
Query: 1689 LDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR 1748
+ + G N +E G L G L D VNQ +C MK R
Sbjct: 6437 KNLFSQAFPENGD---NRDVIEDTLGCLL--GRLSLLDSV--VNQ-------RCHQMKER 6482
Query: 1749 HQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKE---QYSTSLAQSEA 1805
Q++L+ Q + + S L + + + + + +Q + E E Q L + +A
Sbjct: 6483 LQQILNFQNDLKVLFTS----LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
Query: 1806 ELKQVQTLQDELQ---KFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFS 1862
+ +++ D+LQ +Q+ + + + + + G + TL S +R
Sbjct: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDL 6598
Query: 1863 EDVISH-----KGDLRFVTISG---QKVLDMENSFKEGKEPSEI--GNLVKDKLKDATER 1912
D++ GD + + S Q++LD + +G E I L + + A ++
Sbjct: 6599 ADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQK 6658
Query: 1913 YTALHS-----------KCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSD 1961
T H+ + + G L +L + L ++ E+++ +
Sbjct: 6659 ETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV--G 6716
Query: 1962 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS 2021
V + L +++ + L+ L E+Q + ++ + ++ I + + + +
Sbjct: 6717 LVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLL-ISISCSDLESQLNQLGEC 6775
Query: 2022 ILSHFQSLSYSLAERSSLLQK----------AIAQSQSVQESLESLLQSIGEVEQNLEGK 2071
LS+ +S L ++L+ I QS ++ LE Q V Q LE
Sbjct: 6776 WLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE-- 6833
Query: 2072 QVSSLSSGVIQEALATNMKLKQDIARQ---KSSLEATREMVTRFMETADSTTAAVLQG-- 2126
++++ L ++ +++ Q KSS+ +T + R + +T + L
Sbjct: 6834 --------MVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRID 6885
Query: 2127 --------KLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLA 2178
+ V ++ QL + + ++ +++ + E++ K + ++N A
Sbjct: 6886 SQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA 6945
Query: 2179 SGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNL- 2237
I + Q+ + +++ +Q +D + V ++SS D + L
Sbjct: 6946 --------IHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
Query: 2238 --RKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL 2295
K + LQ V E+ + E E+ V+ + W + E + +
Sbjct: 6998 AMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASV 7057
Query: 2296 EKQIEHLKSLLDDWASKGTLVEEINCKGTSL--------ENLIMEITAPDSQ-------- 2339
+ ++ + L D +K VE+I G +L +++M Q
Sbjct: 7058 QNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHM 7117
Query: 2340 -GKTGSILPSVGSSVGS-------VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQE 2391
G+ +L SV S +N Y L E + +S ++ L G L Q
Sbjct: 7118 VGQLKILLKSVLDQWSSHKVAFDKINSY-----LMEARYSLS----RFRLLTGSLEAVQV 7168
Query: 2392 SLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELE 2451
+ + N +++ K+ S+ ++ ++LK + T T T+K E N + LE
Sbjct: 7169 QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK---EVNMRWNNLLE 7225
Query: 2452 QNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 2511
+ + ++Q K L Q + +K ++ S ++ + R +L ++A++
Sbjct: 7226 EIAEQLQSSKALL----------QLWQRYKDYSKQCASTVQQQED----RTNELLKAATN 7271
Query: 2512 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLN 2571
A+ ++ W+ + ++ LG + K + F+ + E +QQ +
Sbjct: 7272 K---DIADDEVATWIQDCNDLLKGLGTV----------KDSLFFLHELGEQLKQQVD--- 7315
Query: 2572 EAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ 2631
+ + S +Q + S++Q L L + + + ++ + + L+
Sbjct: 7316 -------------ASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLE 7362
Query: 2632 DLSEKVRAVGQRLSVQ--------SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 2683
L + + L Q S I + E +K Q+ + S + DL++L+
Sbjct: 7363 ALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN-------- 7414
Query: 2684 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDEL 2743
EL + L D+ KR++ + + +R ++LQ+ L Q F ++
Sbjct: 7415 ---ELGYRLP---LNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF---LEKC 7465
Query: 2744 RTWLDDK-QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 2802
TW++ Q++Q IS + L Q + +E FQ + I+ +G+ LL
Sbjct: 7466 ETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLL-EQ 7524
Query: 2803 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPW-IEDCK 2861
+++ +L L N W+ + ++ R+ + +++ Q+Y+ E L W +E
Sbjct: 7525 GQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSY 7584
Query: 2862 AKMSELRVTLDPVQLESSLLRSKAMLNEVEKRR--SLLEILNSAADILINSSEADEDGIR 2919
MS L P+Q +L +V R+ S + + + +L+++ E ++
Sbjct: 7585 LPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
Query: 2920 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGS 2979
E A I E+ ++ + LEE ++L + ++ EK + + +L F S
Sbjct: 7645 AELAEIQ-------EKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS 7697
Query: 2980 QACSNKNLEKLRAQQEVLQALEPQV-DYLRNFTQ-GLVEDAPDG----SDASQLLHQAEV 3033
Q+ + + E+L A+Q + LE V + + TQ L++D D S L + E+
Sbjct: 7698 QSLPDHH-EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 7756
Query: 3034 AQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSL 3093
Q+++ E+ +++ + +L F + +E+ L ++ ++ G I
Sbjct: 7757 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI------- 7809
Query: 3094 QSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTER 3153
L I LK D + A + +E K +L+ + ++ K +
Sbjct: 7810 --------LIEEMIEKLKKDYQEEIA-----IAQEN-------KIQLQQMGERLAKASHE 7849
Query: 3154 GKARQEQLELTLGRVEDFYRKL--------KGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
KA ++E LG+V D ++ L K L + A ++ + + T + I +
Sbjct: 7850 SKA--SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESE 7907
Query: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ-SAG------------KDCDVQGLEHDME 3252
LA ++ + +Q KL + L + + + S G DCD + + +
Sbjct: 7908 LAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD 7967
Query: 3253 EI-------NARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKP 3305
I + RW + +R +++E KF D WL +E A
Sbjct: 7968 SIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSS 8027
Query: 3306 PSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLES 3365
Y V K ++++ + QR + + ++++ + R+A+ + +
Sbjct: 8028 SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQ 8087
Query: 3366 RWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQ 3425
RW L + + ++L+ + ++F + I +L+ + +L N E +Q +
Sbjct: 8088 RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE--CDVQAK 8145
Query: 3426 IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3485
I + KA +++I + + Q + G+ L + P + ++ E++D L+ E+ R R
Sbjct: 8146 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 8205
Query: 3486 KAALLDQALSNARL-FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE 3544
L RL +DE ++ + E+ED S + D H + AD L +
Sbjct: 8206 YHKKL------IRLPLPDDEHDLSDRELELED---SAALSDLHW---HDRSADSLLSPQP 8253
Query: 3545 IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ 3604
N ++ Q +++ ++ + T V I + D D+ S+AL + ++ Q
Sbjct: 8254 SSNLSLSLAQPLRSERS--GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ 8311
Query: 3605 LATKF--------QSTYEELTGWLREVEEELATSGGQSPTGEQI--------PQFQQRQK 3648
F + L +R++ + L S Q E I P+ K
Sbjct: 8312 DDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYK 8371
Query: 3649 ELKKEVMEHRLVLDTVNEVSRALLE----LVPWRAREGLDKLVSDANEQYKLVSDTIGQR 3704
K + E +D+V + L E L + + + ++++L+ +
Sbjct: 8372 GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 8431
Query: 3705 VDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSID-I 3763
+ +Q+ QQ+ ++ AW+ +T+ +L L + L D T +LQ++K +
Sbjct: 8432 ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKA 8491
Query: 3764 IRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVL 3823
+ H+ ++ + S F ++ LQ++ + +++ + L E L+ A +
Sbjct: 8492 VDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQ 8551
Query: 3824 VNQFWETYEELSPWIE---ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHID 3880
F E L +E + I + S +D E L+ +++ Q++ + E + +
Sbjct: 8552 CQGFHEMSHGLLLMLENIDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRVA 8610
Query: 3881 KLLKIGPQLKELNPEEGEMVE--EKYQKAENMYAQIKEEVRQRALALDEAVSQST 3933
L + QL +N E + +E EK N + +EV + L++ + S+
Sbjct: 8611 SLQDMSCQLL-VNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSS 8664
Score = 218 bits (556), Expect = 1e-55
Identities = 155/450 (34%), Positives = 233/450 (51%), Gaps = 70/450 (15%)
Query: 71 RVADERDRVQKKTFTKWVNKHLMKVRKH--INDLYEDLRDGHNLISLLEVLSGIKLPREK 128
R+ DE++ VQK+TFTKW+N HL K + ++DL+ED++DG L++LLEVLSG KLP E+
Sbjct: 20 RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
Query: 129 GRM--RFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI- 185
GR R H + N+ AL FL+ R++KLVNI + DI DG P + LGL+WTIIL+FQI ++
Sbjct: 80 GRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELT 139
Query: 186 ------------------YISGESGDMSAKEK------------LLLWTQKVTAGYTGIK 215
+S E+ +K K LL W Q TGI+
Sbjct: 140 SNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIE 199
Query: 216 CTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAE-RLGVTRLLDAE 274
+F W G F+++IH RP+LVD+E V+ +SNRENLE AF +AE LG+ RLLD E
Sbjct: 200 VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPE 259
Query: 275 DVDVPSPDEKSVITYVSSIYDAFPKVPEGG-EGISATEVDSRWQEYQSRVDS-------- 325
DVDV PDEKS++TYV+ +P + +G E+ + + + V +
Sbjct: 260 DVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVI 319
Query: 326 ---LIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLE 382
+ WI+Q ++ ++ ++ K Y + HF+ + E ++ +IE L + L
Sbjct: 320 FKEMKVWIEQFERDLTRAQMVESNLQDK--YQSFKHFR----VQYEMKRKQIEHLIQPLH 373
Query: 383 VWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPA--------VERLELLLQIAN 434
G++ L Q + +L ++ +KSL PA + R E+ L+
Sbjct: 374 ---RDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSL-PAPLGTIGAWLYRAEVALREEI 429
Query: 435 KIQ----NGALNCEEKLTLAKNTLQADAAH 460
+Q A + KL K+ LQ AH
Sbjct: 430 TVQQVHEETANTIQRKLEQHKDLLQNTDAH 459
Score = 199 bits (505), Expect = 8e-50
Identities = 435/2542 (17%), Positives = 998/2542 (39%), Gaps = 243/2542 (9%)
Query: 2411 LQWLESKEEVLKSMDAMSSPTKT--------ETVKAQAESNKAFLAE---LEQNSPKIQK 2459
+++LE K +L + S K+ E+V+ ++ +F+ EQ Q
Sbjct: 503 MEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQI 562
Query: 2460 VKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAE 2519
+K+ + + +EAEN K E ++W + + + LEE S+ +
Sbjct: 563 LKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTV 622
Query: 2520 SQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT 2579
+ L+ WL + E MLN + + + QQH +N+A ++
Sbjct: 623 ASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIE 669
Query: 2580 GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRA 2639
+ + + ++++L +N +W EL ++ + +Q D+ +Y + + LS
Sbjct: 670 TCDE--MVSRDLKQQLLLLNGRWRELFMEV-KQYAQADEMDRMKKEYTDCVVTLSAFATE 726
Query: 2640 VGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD 2699
++LS +S VK +++ +I + +D + K + + + LI ++ ++
Sbjct: 727 AHKKLSEPLEVSFM--NVKLLIQDLEDIEQRVPVMDAQYK----IITKTAHLITKESPQE 780
Query: 2700 ELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCP 2759
E K+ T + L++ L +QQ +EL + K
Sbjct: 781 EGKEMFAT----MSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINE 836
Query: 2760 ISAKLER-LQSQLQENEEFQKSL--NQHSGSYEVIVAEGES------LLLSVPPGEEKRT 2810
I LER QS ++ Q+ L ++ ++ +G L +V ++
Sbjct: 837 IITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTR 896
Query: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 2870
LQ Q+ ++ ++ + KKT D + ++ + +K++ +L + + + E
Sbjct: 897 LQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKG-- 954
Query: 2871 LDPVQLESSLLRSKAMLNEVEKR--RSLLEILNSAADILINSSEADEDGIRDEKAGINQN 2928
DP +L L R +++++R + L+ + DIL E ++ G+++ +++
Sbjct: 955 -DPEEL---LRRHTEFFSQLDQRVLNAFLKACDELTDIL---PEQEQQGLQEAVRKLHKQ 1007
Query: 2929 MDAVTEELQAKTGSLE---EMTQRLREFQESFKNIEKKV-----EGA----KHQLEIFDA 2976
+ E L+ E + L +E ++++ EG+ K F
Sbjct: 1008 WKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSD 1067
Query: 2977 LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQ 3036
G K L+ + L +P V D P
Sbjct: 1068 KGPHHLCEKRLQLIEELCVKLPVRDP------------VRDTPG------------TCHV 1103
Query: 3037 EFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT---DSL 3093
E++ ++S + + + R E S ++ + +L G+ DT +
Sbjct: 1104 TLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV 1163
Query: 3094 QSQIEDVR---------LFLNKIHVLKLDIEASEAECRHMLEEEGTLD-----LLGLKRE 3139
+ +E++R L K + L +SE E + +E L L+ L E
Sbjct: 1164 KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSE 1223
Query: 3140 LEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV 3199
+E + G + + + LE + ++ + + + D E + L
Sbjct: 1224 VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLL-------- 1275
Query: 3200 EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWN 3259
+ +QQ +K V + QQ G+G + G + ++ ++ + +
Sbjct: 1276 -LHHQQKTKRISAKKRDVQQQIAQAQQ----GEGGLPDRGHE--------ELRKLESTLD 1322
Query: 3260 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPS-AEYKVVKAQIQ 3318
L + ++ ++Q L +F+ E ++ +L T ++++ S + + + ++++
Sbjct: 1323 GLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSELE 1380
Query: 3319 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3378
+ K + + + L E I + +++ + Q +S++ + +L
Sbjct: 1381 QTKEFSKRTESIAVQAENLVKEASEIPLGPQ--NKQLLQQQAKSIKEQVKKLEDTLEEDI 1438
Query: 3379 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3438
K +E + F E +S +++ EK+L E T ++ + QI + K ++IE+
Sbjct: 1439 KTMEMVKTKWDHFGSNFETLSVWITEKEKELNALE---TSSSAMDMQISQIKVTIQEIES 1495
Query: 3439 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC-CRKAALLDQALSNA 3497
+ + + QS + + E + K+ ++ E+++ C + +L LS
Sbjct: 1496 KLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGH-LSQQ 1554
Query: 3498 RLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK 3557
+ F E+ ++ ++E EDKL+ ++ +H+ L + + +++ AI
Sbjct: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQAL----ESLSSAIT 1610
Query: 3558 NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELT 3617
A ++ + + ++ ++ +Y DI + + LE L +Q +EL+
Sbjct: 1611 AFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALE---NLLAHWQRLEKELS 1665
Query: 3618 GWLREVE--EELATSGGQSPTGEQIPQFQQRQ--KELKKEVMEHRLVLDTVNEVSRALLE 3673
+L +E E A+S + +++ + Q + L+ EV+ + ++ +L
Sbjct: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
Query: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETK 3733
+ + + + +E+++ + I +R++ + + + QQ+++ + W+
Sbjct: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---- 1781
Query: 3734 RKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI---------FGTC 3784
+ L + QTT+++ + + + RHKD E+ S + E+ G+
Sbjct: 1782 -------KLFLSELQTTSEISIMD-HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSL 1833
Query: 3785 GE-EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 3843
G E +LQ K E Q +E S + R L + +F +++ LS + + R
Sbjct: 1834 GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH----LAEFLQSHASLSGILRQLRQ 1889
Query: 3844 LIAQLPSPAIDHEQLRQQQ-EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902
+ S + L ++ + Q +++ +D +L L E
Sbjct: 1890 TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQY--HLKIGSSEQRTS 1947
Query: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962
A+ + +++ EA + + F D+ E +L+++E++ R L
Sbjct: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
Query: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLA-AKEIQDKLD 4021
+++ + EL + LK + +++ A KD+A A E+ +++
Sbjct: 2008 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREIN 2061
Query: 4022 QMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSI 4081
++ W+D K E + + +++L ++ +A+ +++ ++ + D
Sbjct: 2062 RLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI-VTRTTIKDQED 2120
Query: 4082 IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE---VRKSIDEMNNAWEN 4138
+K ET K + + ++L+ G L+ + + V+ ++ + W +
Sbjct: 2121 LKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLD 2180
Query: 4139 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE- 4197
+++ +E +++L ++ T + W +N V P + +++ + + L
Sbjct: 2181 VSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCV------PQMAENISNLDNHLRAE 2234
Query: 4198 --MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAH 4255
+KEF+ EV + + +E+L+ K D + E +L+ + +L +K+ H
Sbjct: 2235 ELLKEFESEVKNKALRLEELH-------SKVNDLKELTKNLETPPDLQFIEADLMQKLEH 2287
Query: 4256 RQHKLEGALLALGQF-------QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4308
+ E A L F + + ++ +W T EE L ++ L K
Sbjct: 2288 AKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL-----MNCAQNETCEALKKV 2342
Query: 4309 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4368
++ ++ + Q+ + + + N L + SL + + + E+V Q + +
Sbjct: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
Query: 4369 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4428
LQ +L+ + F +++F ++ S G + +L + + +
Sbjct: 2403 LQESLE--KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2460
Query: 4429 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATE 4488
+ + +G+ L + S ++ + +++ + + K L++ +
Sbjct: 2461 SKLDAVTQEGQ-TLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGS 2519
Query: 4489 FQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV--FANEVNAHRDQIIELDQ 4546
F++ ++ W+ E+ N + + + E HKV F E+ A R+ + +L Q
Sbjct: 2520 FEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQ 2579
Query: 4547 TGNQLKFLSQK-----QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 4601
G + LS++ Q+ L LL S Q+ +++ + E+ RS A + + EA
Sbjct: 2580 RG---QLLSEEGHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEA 2632
Query: 4602 WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTG-RAL 4660
+ + W++ + L D ++ +LS+ ++ G + + I G +AL
Sbjct: 2633 LQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL 2692
Query: 4661 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 4720
+ E + + L +++ W + SV Q LE + +++ L W+
Sbjct: 2693 RSSN--KEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWME 2750
Query: 4721 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTW 4780
V+ ++ L L+D + E T + L REL E + D++
Sbjct: 2751 SVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFK 2810
Query: 4781 VKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL 4840
Q +EL T+++ + ++ K ++E+ +K ++ D VH +WL A++ L +
Sbjct: 2811 DTAQ-EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDM 2869
Query: 4841 PDDTEALQSLIDTHKEFMKKVE 4862
D+ A Q + KE + E
Sbjct: 2870 SGDSSATQKKLSKIKELIDSRE 2891
Score = 154 bits (389), Expect = 2e-36
Identities = 445/2581 (17%), Positives = 976/2581 (37%), Gaps = 297/2581 (11%)
Query: 2546 LNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVEL 2605
L + Q + ++E +R+Q E L + L G +SL + V+ Q W +
Sbjct: 344 LQDKYQSFKHFRVQYEMKRKQIEHLIQP----LHRDGKLSLDQALVK-------QSWDRV 392
Query: 2606 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 2665
T +L Q+D+++ + L A+ + ++VQ ++++LE+
Sbjct: 393 TSRLFDWHIQLDKSL--PAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHK 450
Query: 2666 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKR---LETVALPLQGLEDLAADR 2722
++ + + E + + L+D ++ T L L +E L
Sbjct: 451 DLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKY 510
Query: 2723 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 2782
RL + L + +L++W+ +++ +E+L E K
Sbjct: 511 --RLLSLLVLAES------KLKSWIIKYGRRES--------VEQLLQNYVSFIENSKFFE 554
Query: 2783 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQK 2842
Q+ +Y+++ E + + EE + + E W LS + +S L++ +
Sbjct: 555 QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISN 614
Query: 2843 AQKYQWHVEDLVPWIEDCK--------AKMSELRVTLDPVQLESSLLRSKAMLNEV---- 2890
+Y V L W+ED + AK R +Q +++ + L E
Sbjct: 615 WDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEM 674
Query: 2891 ---EKRRSLLEILNSAADILI---NSSEADE-DGIRDEKAGINQNMDAVTEELQAKTG-- 2941
+ ++ LL + ++ + ++ADE D ++ E + A E K
Sbjct: 675 VSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEP 734
Query: 2942 -------------SLEEMTQRLREFQESFKNIEKKV---------EGAKHQLEIFDALGS 2979
LE++ QR+ +K I K E K L
Sbjct: 735 LEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKE 794
Query: 2980 QACSNKNLEK--LRAQQEVLQALEPQVDYLRNFTQGL------VEDAPDGSDASQLLHQA 3031
Q K L Q++L LE + +F L + + +S L Q
Sbjct: 795 QLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQ- 853
Query: 3032 EVAQQEFLEVKQRVNSGCVMMENKLEGIGQF--------HCRVREMFSQLADLDDELDGM 3083
QE L ++ ++E + + +F H + Q+AD+ M
Sbjct: 854 --KHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSM 911
Query: 3084 GAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLK------ 3137
+ T + +E + K + ++E + LEE+G + L +
Sbjct: 912 ---VKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 968
Query: 3138 ----RELEALNKQCGKLTE-RGKARQEQLELTLGRVEDFYRKLKG-----LNDATTAAEE 3187
R L A K C +LT+ + Q+ L+ + ++ ++ L+G L E+
Sbjct: 969 QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEK 1028
Query: 3188 AEALQWVVGTEVEI-----INQQLADFKMFQKEQV-----DPLQMKLQQVNGLGQGLIQS 3237
L V E+ + Q K+ ++ +V P + +++ + + ++
Sbjct: 1029 NRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKL 1088
Query: 3238 AGKD--CDVQGLEH-DMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3294
+D D G H ++E+ A ++ +K+ + + ++ +F SW++
Sbjct: 1089 PVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFS-------SWIS 1141
Query: 3295 DTE---ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA 3351
E + I + +A + VK ++E ++ + R T+ L++ + + +
Sbjct: 1142 TNETQLKGIKGEAIDTANHGEVKRAVEE---IRNGVTKRGETLSWLKSRLKVLTEVSSEN 1198
Query: 3352 DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLAN 3411
+ +K +L L S + L++ + +K L + F + + + E+ ++
Sbjct: 1199 EAQKQGDELAKLSSSFKALVTLLSEVEKMLSN-------FGDCVQYKEIVKNSLEELISG 1251
Query: 3412 SEPVGTQTAKI---------QQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQ 3462
S+ V Q KI QQ ++ H+ + I DV Q +I Q+ ++
Sbjct: 1252 SKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQ--QIAQAQQGEGGLPDR 1309
Query: 3463 GVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEV----EDKL 3518
G E++ L++ ++ R+ + L F ++ V+ +L + E L
Sbjct: 1310 G--HEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFL 1367
Query: 3519 SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL 3578
S ++ ++ Q + E I + +N+ +K + ++ L+Q++
Sbjct: 1368 SFSSLESLSSEL--EQTKEFSKRTESIAVQAENL---VKEASEIPLGPQNKQ--LLQQQA 1420
Query: 3579 DGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL-ATSGGQSPTG 3637
IK + + T + ++T+E + F S +E L+ W+ E E+EL A S
Sbjct: 1421 KSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMD 1480
Query: 3638 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLV 3697
QI Q + +E++ ++ + + E +++ + V G + Q +
Sbjct: 1481 MQISQIKVTIQEIESKLSS----IVGLEEEAQSFAQFV----TTGESARIKAKLTQIRRY 1532
Query: 3698 SDTIGQRVDEIDAAI----QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQL 3753
+ + + ++ I + Q++E+ V+E + KL PI++ T
Sbjct: 1533 GEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAV--PIKICSSATETYK 1590
Query: 3754 QVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQ----EKTESLIQQYEAISLL 3809
+Q+ H D L S S I +K V + ++ +L QQYE I
Sbjct: 1591 VLQE--------HMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRR 1642
Query: 3810 NSERYARLERAQVLVNQFWETYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQ 3867
ER LE + + W+E E +A ++ A D ++ + + ++
Sbjct: 1643 AKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISA-DRVKVEGELQLIQA 1701
Query: 3868 LRESIAEHKPHIDKLLKIGPQLKEL-NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALD 3926
L+ + KLL++ L + + ++ +M++ ++ + + + + + +R L
Sbjct: 1702 LQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1761
Query: 3927 EAVSQSTQITE----FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVE 3982
V++ Q E F I+ L L+ S M + ++ +K E
Sbjct: 1762 SVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV---------ALTRHKDHAAE 1812
Query: 3983 LEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFL 4042
+E + ++L+ +L + D L +Q K + +E+ E R++
Sbjct: 1813 VESKKGELQSLQGHLAKLGSLGRAEDLHL----LQGKAEDCFQLFEEASQVVERRQLALS 1868
Query: 4043 DVLELAEKFWYDMAALLTTIKDTQDIVHDL---ESPGIDPSI--IKQQVEAAETIKEETD 4097
+ E + ++ +L ++ T + + + ES I+ + Q +A E+ D
Sbjct: 1869 HLAEFLQSH-ASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1927
Query: 4098 GLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAA 4157
G+ + ++ +G+ ++ R + D++ ER++ L Q+
Sbjct: 1928 GILSKAQYHLKIGS-------SEQRTSCRATADQLCGE--------VERIQNLLGTKQSE 1972
Query: 4158 VQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNH 4217
L+ F ++K TD +K+ + + ++ V+ Q+E E +H
Sbjct: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVF-NQLEDELNSH 2031
Query: 4218 QGEL--MLKKATDETDRDIIREP-----LTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270
+ EL + KA +D+ P + L+ W++ I Q + G + + ++
Sbjct: 2032 EHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREY 2091
Query: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4330
Q+ + L + ++ + I D + ++ +KH KN + Q ++ G
Sbjct: 2092 QNLKSAVSKVLENASSVIVTRTTIK-DQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGK 2150
Query: 4331 EL---LESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQ----------STLQQAQ 4377
L L+ D S +++ +E+ W V +K EE +L+ ST + +
Sbjct: 2151 HLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIE 2210
Query: 4378 GFHSEIEDFLLE-LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLD 4436
G+ + + E ++ +++ L A + + + EL+S++ +E L
Sbjct: 2211 GWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLET 2270
Query: 4437 KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4496
L + D L QK E K L++ +T+ + + +
Sbjct: 2271 PPDLQFIEAD--------------LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDI 2316
Query: 4497 INWLTLAEQSL-NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS 4555
W T E+SL N A N +++ K E+ + + I + N L
Sbjct: 2317 TTWFTKVEESLMNCAQ------NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2370
Query: 4556 QKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESH 4615
++ + + + + E V Q + SL ++ + K F E+ ++ +W A++
Sbjct: 2371 HSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWFLGAKAA 2428
Query: 4616 LDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDN 4675
+ + D ++ +L + ++ Q D + G+ L L + +
Sbjct: 2429 AKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAH-LSKQIVSSIQE 2487
Query: 4676 FLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGD 4735
+ + +++ + ++ + L++ G F D + L W++++E + +
Sbjct: 2488 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2547
Query: 4736 LDLVMNLMDAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL-QELSTRW 4792
+ + HKV F EL ++ L + G+ L E +G+L +L T
Sbjct: 2548 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHG--AGQEGRLCSQLLTSH 2605
Query: 4793 DTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLID 4852
+ +++ K + AL++ E + + + W+ + L + + L+ +
Sbjct: 2606 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLS 2665
Query: 4853 THKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQ 4912
++ + E V +N A+ GE L + + I+ + ++ + ++++ + Q
Sbjct: 2666 QIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQ 2725
Query: 4913 QRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPI-PQNIDRVKALIAEH-QTFME 4970
LE+ +S+ E +L W++ ++ Q+ + P+ PQ + K ++ +H Q+ +
Sbjct: 2726 STLESVISQWNDYVERKNQLEQWME----SVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2781
Query: 4971 E 4971
E
Sbjct: 2782 E 2782
Score = 128 bits (322), Expect = 1e-28
Identities = 348/1922 (18%), Positives = 743/1922 (38%), Gaps = 191/1922 (9%)
Query: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGT-EVEIINQ 3204
Q + ER EL L ++E K + L+ A E++ W++ E + Q
Sbjct: 481 QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLA--ESKLKSWIIKYGRRESVEQ 538
Query: 3205 QLADFKMFQKEQ--VDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3262
L ++ F + + ++ Q + + +++ G + + + M E A+W L+
Sbjct: 539 LLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLS 598
Query: 3263 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3322
+V + L+E + + ++ + + L +WL D E+++ + ++ +
Sbjct: 599 VEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDF---------FRN 649
Query: 3323 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3382
L + A D G + ++ + + QL L RW EL + + Q +
Sbjct: 650 LPHWIQQHTAMND----AGNFLIETCDEMVSRDLKQQLLLLNGRWRELFME-VKQYAQAD 704
Query: 3383 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3442
++ + K++ + +S F + KKL+ V K+ Q + EDIE
Sbjct: 705 EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDL------EDIEQRVPV 758
Query: 3443 VHQAVKIGQSLSSL---TSPAEQG-VLSEKIDSLQARYSEIQDRCCRKAALLD--QALSN 3496
+ KI + L SP E+G + + L+ + +++++ C L + Q L
Sbjct: 759 MDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKE--CYSPLLYESQQLLIP 816
Query: 3497 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQ-HADHLALNEEIVNRKKNVDQA 3555
+ + L ++ +++ +V ++ + L +Q H + LA E N KK +
Sbjct: 817 LEELEKQMTSFYDSLGKI-NEIITVLEREAQSSALFKQKHQELLACQE---NCKKTLTLI 872
Query: 3556 IKNGQALLKQTTGEEVL------LIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKF 3609
K Q++ K T VL +Q ++ I + + + + +E +L KF
Sbjct: 873 EKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKF 932
Query: 3610 QSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR 3669
+ + EL LR +E L G + +R E ++ + VL+ +
Sbjct: 933 EESRAELEKVLRIAQEGLEEKGDPE-------ELLRRHTEFFSQLDQR--VLNAFLKACD 983
Query: 3670 ALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV 3729
L +++P + ++GL + V ++Q+K D G+ + L
Sbjct: 984 ELTDILPEQEQQGLQEAVRKLHKQWK---DLQGEAPYHL---------------LHLKID 1025
Query: 3730 AETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQK 3789
E R L ++ R E D+ T +L Q+ I H+ + H C E++
Sbjct: 1026 VEKNRFLASVEECRTELDRET-KLMPQEGSEKIIKEHRVFFSDKGPHH-----LC-EKRL 1078
Query: 3790 TVLQEKTESL--------------IQQYEAISLLNSERYARLERAQVLVNQFWETYEELS 3835
+++E L + E + ++S Y +L + + E S
Sbjct: 1079 QLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDS-TYRKLMEDPDKWKDYTSRFSEFS 1137
Query: 3836 PWIEETRALIAQLPSPAID---HEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL 3892
WI + + AID H ++++ EE+R E + LK+ ++
Sbjct: 1138 SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS- 1196
Query: 3893 NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL 3952
E + QK + A++ + L E + + E + +LE L
Sbjct: 1197 --------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1248
Query: 3953 SSRLRMPPLIPAEVDKI--RECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4010
S + + + +KI E + + + + ++ A KR ++ I ++Q +
Sbjct: 1249 ISGSKE---VQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
Query: 4011 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4070
L + ++L ++ + ++ E +E + L E+F T K+T +V
Sbjct: 1306 LPDRG-HEELRKLESTLDGLERSRERQERRIQVTLRKWERF--------ETNKET--VVR 1354
Query: 4071 DLESPGI--DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKS 4128
L G + + +E+ + E+T + E I + +L+ E K
Sbjct: 1355 YLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQ 1414
Query: 4129 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT-------- 4180
+ + K+ KE+++KLED ++ ++ + ++ +D + L
Sbjct: 1415 L------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKE 1468
Query: 4181 MPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK-KATDETDRDIIREPL 4239
+ + T + + Q++++K E+ + + L + + + T E+ R I+ L
Sbjct: 1469 LNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKL 1526
Query: 4240 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4299
T+++ E L E + + G L +F+ L ++ ++ E+ L I
Sbjct: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1586
Query: 4300 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4359
L +H L + + + + + + +++ + S A+ Q +E +L
Sbjct: 1587 ETYKVLQEHMDLCQALESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYEDIL 1640
Query: 4360 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETARE-QLDTHM 4418
++ +ER+ L++ L Q E+ FL L R E++ S+ + E +L
Sbjct: 1641 RRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQ 1700
Query: 4419 ELYSQLKAKEETYNQLLD--KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4476
L +++ ++ Y++LL + + S+DD + + L+++W + + +R
Sbjct: 1701 ALQNEVVSQASFYSKLLQLKESLFSVASKDDV---KMMKLHLEQLDERWRDLPQIINKRI 1757
Query: 4477 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 4536
+ L+ + +F L F W+ L L S S++ + V + HK A EV +
Sbjct: 1758 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV--ALTRHKDHAAEVES 1815
Query: 4537 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 4596
+ ++ L +L L + +D+ L++ +E+ Q +ER R L A
Sbjct: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ-VVER-RQL--ALSHLA 1871
Query: 4597 QFHEAWKKLIDWLEDAESHLDSELEIS-NDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 4655
+F ++ L L +++ ++ N+ D I+ L+ + K L D +
Sbjct: 1872 EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILS 1931
Query: 4656 TGR-ALKEKTLLPEDSQK--LDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDAL 4712
+ LK + S + D GEV ++ + G +Q + + + F D
Sbjct: 1932 KAQYHLKIGSSEQRTSCRATADQLCGEV-ERIQNLLG---TKQSEADALAVLKKAFQDQK 1987
Query: 4713 QALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIE 4772
+ L+ + +E + +++ + + + EL + LK +++ +
Sbjct: 1988 EELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ 2047
Query: 4773 NSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQ 4832
V ++ L WD +L Q + + +++ + + L A
Sbjct: 2048 KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
Query: 4833 TLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILA---VCHPDCITT 4889
+ R + D E L+ H+ K+ K+ D+++ + G+ +L+ H +
Sbjct: 2108 VIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSL 2166
Query: 4890 IKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQE 4949
+K + ++ +V +++ RL +LS +E+ W + + E
Sbjct: 2167 VKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGW----SNNCVPQMAE 2222
Query: 4950 PIPQNID---RVKALIAEHQT-------FMEEMTRKQPDVDRVTKTYKRKNIE-PTHAPF 4998
I N+D R + L+ E ++ +EE+ K D+ +T KN+E P F
Sbjct: 2223 NI-SNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELT-----KNLETPPDLQF 2276
Query: 4999 IE 5000
IE
Sbjct: 2277 IE 2278
Score = 123 bits (309), Expect = 4e-27
Identities = 393/2123 (18%), Positives = 819/2123 (38%), Gaps = 331/2123 (15%)
Query: 1193 LEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNL------DLERYQ 1246
LE T H D ++ + V++ I +V E RL L L YQ
Sbjct: 6684 LEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQ 6743
Query: 1247 EKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQA 1306
K Q+ + R++ + I S+LES LG+ W+ T + + +
Sbjct: 6744 PKLYQVLDDGKRLL--ISISCSDLESQLNQLGEC---------WLSNTNKMSKELHRLET 6792
Query: 1307 EDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQK 1366
+L Q+ I Q+ D+ + ++QQ T+ ++ E+ AF+E ++
Sbjct: 6793 ----ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKE 6848
Query: 1367 SPGK---RRRMLSSSDAITQ-EFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEE 1422
+ + +LS+ + + + + +D T + L + +Q +++ + ++E+ ++
Sbjct: 6849 VDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTN-IPAVQEKLHQLQM 6907
Query: 1423 EKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILE--QQVLSEELTTKKEQ 1480
+K + E++ W+S + Q + +++ KAI E Q+ ++ +Q
Sbjct: 6908 DKLPSRHAISEVMSWISLMENVIQ---KDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQ 6964
Query: 1481 VS-EAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAH- 1538
++ + + S + ++ + +K +EQL A+NK++ L ++Q L+ L
Sbjct: 6965 LTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESW 7024
Query: 1539 --------------QTEQKTLQKQ-----QNTCHQQLEDLCSWVGQAERALAGHQGRTTQ 1579
+T++K L++Q Q + L+D C + +A + Q
Sbjct: 7025 SEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKD-CQDLEDLIKAKEKEVEKIEQ 7083
Query: 1580 QDLSALQKNQSD-------------------------LKDLQDDIQNRATSFATVVKDIE 1614
L+ +Q + D LK L + ++ +S I
Sbjct: 7084 NGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKIN 7143
Query: 1615 GFMEENQTKLSP-RELTALREKLHQAKEQYEALQEETRVAQKELEE--AVTSALQQETEK 1671
++ E + LS R LT E + + + LQ++ ++ L++ ++T+ L +E
Sbjct: 7144 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP 7203
Query: 1672 SKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGV 1731
+ L + + V LL + Q S A L+ +
Sbjct: 7204 PVT-----------ETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQ------------L 7240
Query: 1732 NQAPEKLDKQC----EMMKARHQELLSQQQNFILATQSAQAFLDQHGHNL----TPEEQQ 1783
Q + KQC + + R ELL N +A ++ L T ++
Sbjct: 7241 WQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSL 7300
Query: 1784 MLQQKLGE-LKEQYSTSLAQS----------------EAELKQVQTLQD---ELQKFLQD 1823
+LGE LK+Q S A + +A KQ +LQ + + F +
Sbjct: 7301 FFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKS 7360
Query: 1824 HKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVL 1883
+ E+W+ +E+ L+ SS L ++ +R + L+F +++
Sbjct: 7361 LEALEAWIVEAEEILQGQDPSHSSD--LSTIQERMEELKGQM------LKFSSMAPDLDR 7412
Query: 1884 DMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADS 1943
E ++ EI ++++ ++ + S+ T S L L Q+ F +
Sbjct: 7413 LNELGYRLPLNDKEI-----KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF---LEK 7464
Query: 1944 LQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIME 2003
+ WM+ +KL + + +L++Q A E + Q+ L + D
Sbjct: 7465 CETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQI----LHSIIIDGQR 7520
Query: 2004 IEGEPAPDHRHVQETTDSILSH-FQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIG 2062
+ + D R ++LS+ +Q + +R ++ I Q Q +E E L + +
Sbjct: 7521 LLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV 7580
Query: 2063 EVEQNLEGKQVSSLSSGVI--QEA--LATNMKLKQDI-ARQKSSLEATREMVTRFMETAD 2117
EV +S L S I Q+A L ++ K+ + RQ+ S T E + + +AD
Sbjct: 7581 EVSY----LPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7636
Query: 2118 STTAAVLQGKLAEVSQRFEQ--LCLQQQEK---------ESSLKKLLPQAEMFEHLSGKL 2166
S A LQ +LAE+ ++++ + L++Q+K E K + E KL
Sbjct: 7637 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL 7696
Query: 2167 QQFMENKSRML------------ASGNQPDQDITHFF------------QQIQELNLEME 2202
Q + + L A G+ D D+T I LN +E
Sbjct: 7697 SQSLPDHHEELHAEQMRCKELENAVGSWTD-DLTQLSLLKDTLSAYISADDISILNERVE 7755
Query: 2203 DQQENLDTLEH-LVTELSSCGFAL-----------DLCQH----------------QDRV 2234
Q + L H L G L +LC+ ++ +
Sbjct: 7756 LLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMI 7815
Query: 2235 QNLRKDFTELQKTVKEREKDASSCQEQLDEFR----------KLVRTFQKW--------- 2275
+ L+KD+ E +E + E+L + KL + +W
Sbjct: 7816 EKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAA 7875
Query: 2276 ----LKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLE-NLI 2330
LKET ++ + +MS+ L + H++S L +K + + N + + N
Sbjct: 7876 RVKKLKETLVAVQQLDKNMSS--LRTWLAHIESEL----AKPIVYDSCNSEEIQRKLNEQ 7929
Query: 2331 MEITAPDSQGKTG--SILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHE 2388
E+ + TG S+L + + T + IQ +++ ++ + + E
Sbjct: 7930 QELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSME 7989
Query: 2389 RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2448
R+ ++ ++ + + WL+S E + SS K + + +AF
Sbjct: 7990 RRLKIEETWRLWQKFLDDYSRFEDWLKSSERT--AAFPSSSGVIYTVAKEELKKFEAFQR 8047
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEES 2508
++ + +++ + + L + A + K++ E N RW+ + + R+L+
Sbjct: 8048 QVHECLTQLELINKQYRRL-ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHF 8106
Query: 2509 ASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ-- 2566
F+ A + WL E +L + N+ + + VQ +K+ +A +Q+
Sbjct: 8107 IGQREEFETARDSILVWLTEMDLQL---------TNIEHFSECDVQAKIKQLKAFQQEIS 8157
Query: 2567 --HEQLNEA-AQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKS 2623
H ++ + AQG L + +++EL + + E+ ++ ++ + +
Sbjct: 8158 LNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPD 8217
Query: 2624 TQYQELLQDLSEKVRAVGQRL-----SVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 2678
++ ++L + A L S S +S QP + L +RS+
Sbjct: 8218 DEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS-NLSLSLAQPLRSE-----RSG 8271
Query: 2679 KEAQTLCDELSVLIGEQYLKDELKKRLETV---ALPLQGLEDLAADRINRLQAALASTQQ 2735
++ D + + Y +L + LE+ ALP + E+ D+ L+ A+ +
Sbjct: 8272 RDTPASVDSIPLEWDHDY---DLSRDLESAMSRALPSED-EEGQDDKDFYLRGAVGLSGD 8327
Query: 2736 FQQMFDELRTW---LDDK--QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEV 2790
+ ++R LDD Q QQ +N I +K + + K L + S S +
Sbjct: 8328 HSALESQIRQLGKALDDSRFQIQQTENI-IRSKTPTGPELDTSYKGYMKLLGECSSSIDS 8386
Query: 2791 IVAEGESLLL---SVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQ 2847
+ L S+P + + Q + + WE L + ++ R+K +QK Q++
Sbjct: 8387 VKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFN 8446
Query: 2848 WHVEDLVPWIEDCKAKMSELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAA 2904
+ + W+ D + ++ +L+ ++ D +E + + K + V+ R++++ +N +
Sbjct: 8447 SDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCS 8506
Query: 2905 DILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNI---E 2961
+ + ++D + +N D V L+ G L++ + + F E +
Sbjct: 8507 PEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 8566
Query: 2962 KKVEGAKHQLEIFDA-LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD 3020
+ ++ K+++ D+ L ++ + + + ++ + E+L++ + +V L++ + L+ +A +
Sbjct: 8567 ENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLES-QLRVASLQDMSCQLLVNA-E 8624
Query: 3021 GSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD--- 3077
G+D + + V + + V+ +E L ++ S DL
Sbjct: 8625 GTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL-----------DVSSSQQDLSSWS 8673
Query: 3078 --DELDGMGAI----GRDTDSLQ 3094
DELD G++ GR T + Q
Sbjct: 8674 SADELDTSGSVSPTSGRSTPNRQ 8696
Score = 49.7 bits (117), Expect = 8e-05
Identities = 113/608 (18%), Positives = 233/608 (38%), Gaps = 90/608 (14%)
Query: 4480 EEALNLATEFQNSLQEFIN-----------WLTLAEQSLNIASPPSLILNTVLSQIEEHK 4528
+E L F NS+Q F W+ E+ L A ++ + + + + K
Sbjct: 296 DEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQ---MVESNLQDKYQSFK 352
Query: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588
F + R QI L Q ++ LS Q +V + W++V R + L
Sbjct: 353 HFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALV---------KQSWDRVTSRLFDWHIQL 403
Query: 4589 DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK----IKLQLSKHKEFQKTLG 4644
D K + WL AE L E+ + ++ I+ +L +HK+ +
Sbjct: 404 D------KSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTD 457
Query: 4645 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLF 4704
+ + RT R++ + P+ L ++ +++ V S E L
Sbjct: 458 AHKRAFHEIYRT-RSVNGIPVPPDQ-------LEDMAERFHFVSSTS--------ELHLM 501
Query: 4705 SGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVF---QKELGKRTGTVQ 4761
+F++ L+ L E +L +G + V L+ + F K + T Q
Sbjct: 502 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 561
Query: 4762 VLKRSGRELI--ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDT 4819
+LK++ + + S ++ V + E + +W + S +S LE+ + + + +T
Sbjct: 562 ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 621
Query: 4820 VHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVE---EKRVDVNSAVAMGE 4876
V L WL +AE+ L + +E + K+F + + ++ +N A G
Sbjct: 622 VASLQAWLEDAEKML-------NQSE------NAKKDFFRNLPHWIQQHTAMNDA---GN 665
Query: 4877 VILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWI 4936
++ C +K + ++ R+ E+ KQ+ Q E+ + + + +
Sbjct: 666 FLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-----ADEMDRMKKEYTDCVVTL 720
Query: 4937 QWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHA 4996
T ++ EP+ + VK LI + +E++ ++ P +D K + H
Sbjct: 721 SAFATEAHKKLSEPLEVSFMNVKLLIQD----LEDIEQRVPVMDAQYKIITK----TAHL 772
Query: 4997 PFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDAL 5056
E + G++ + + + E +P + + QQ+ + E ++++
Sbjct: 773 ITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYES----QQLLIPLEELEKQMTSFY 828
Query: 5057 DRLEELKE 5064
D L ++ E
Sbjct: 829 DSLGKINE 836
Score = 34.3 bits (77), Expect = 3.5
Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 12/227 (5%)
Query: 585 NLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARL--- 641
+L ++ L EE +L+R E D+ ++ELQ++ + + +V+ + + L
Sbjct: 8448 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8507
Query: 642 ----YEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLN 697
+ K S++ ++ G+ + L+E L F + L+ L
Sbjct: 8508 EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE 8567
Query: 698 EKEEEELAYDWSDNNSNISAKRNYFSELTM---ELEEKQDVFRSLQDTAELLSLENHPAK 754
+ + D+N + +++ +L EL E Q SLQD + L L N
Sbjct: 8568 NIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL-LVNAEGT 8626
Query: 755 QTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESF 801
+EA V +K L V +H+KE S ++L S+
Sbjct: 8627 DCLEA-KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSW 8672
>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
Length = 3677
Score = 351 bits (900), Expect = 1e-95
Identities = 526/2787 (18%), Positives = 1138/2787 (40%), Gaps = 333/2787 (11%)
Query: 2222 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2281
G+ +DL HQ RV N+ + ++L T K E + + QEQ++ + E +
Sbjct: 376 GYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQS 435
Query: 2282 SIPPTETSMSAKELEKQIEHLKSLLDDWASKG---TLVEEINCKGTSLENL--------I 2330
++ + ++L++ L+DW +K T E G LE+L +
Sbjct: 436 NLHRVLMDLQNQKLKE--------LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 487
Query: 2331 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2390
++ Q + S+ V V +G H L E + D ++ + +R
Sbjct: 488 LQEDLEQEQVRVNSLTHMV-VVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRW 543
Query: 2391 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN--KAFLA 2448
LQ IL + + + +E WL KE+ + + + E + + + KA L
Sbjct: 544 VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 603
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENW-------------------KKIQEELNS 2489
+ +Q+ K+ +K+ L L +Q+ E W +I + + +
Sbjct: 604 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 663
Query: 2490 RWERATEVTVA---------------------------RQRQLEESASHLACFQAAESQL 2522
T+ TV ++RQ+ + ++L
Sbjct: 664 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 723
Query: 2523 RPWLMEKE-LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 2581
W+ E ++ + + K++V + +E + ++ + + +AQ ++
Sbjct: 724 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 783
Query: 2582 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 2641
+ ++ +++ + +N +W+E L+ R + ++ Y +L Q L +
Sbjct: 784 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQL-QQLEQMTTTAE 842
Query: 2642 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC-DELSVLIGEQYLKDE 2700
L +Q ++P A+K QL+ +C DE++ L G Q +
Sbjct: 843 NWLKIQPTTPSEPTAIKSQLK---------------------ICKDEVNRLSGLQPQIER 881
Query: 2701 LKKRLETVALPLQGLEDLAADR-----INRLQAALASTQ----------------QFQQM 2739
LK ++++AL +G + D N + + Q ++Q+
Sbjct: 882 LK--IQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQET 939
Query: 2740 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN-QHSGSYEVIVAEGESL 2798
+RTW+ +++ + E ++ +L E + Q SL Q SG Y + E
Sbjct: 940 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE-- 997
Query: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858
+ P E R Q++ E++ W++LS + + +L++ M K +K Q H++ L W+
Sbjct: 998 MSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMA 1057
Query: 2859 DCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-ED 2916
+ + E L D L+ L + + ++++++ + L +N + N +E +
Sbjct: 1058 EVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS 1117
Query: 2917 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFD 2975
+ E +N D + +++ A+ +L+ ++ Q+ + + + A+ + LE
Sbjct: 1118 RLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDF 1177
Query: 2976 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3035
+ K +E+++ +E Q E +V L ++ AP + + L + E
Sbjct: 1178 EYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA-LKKELETLT 1236
Query: 3036 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3095
+ + R+N C +E E +H E+ S L + L+ + + T+++
Sbjct: 1237 TNYQWLCTRLNGKCKTLE---EVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPG 1289
Query: 3096 QIEDVRLFLNKIHVLKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTE 3152
E++ L+ + L E + + R + L + G +D L + ELE N + +L E
Sbjct: 1290 GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL-INEELETFNSRWRELHE 1348
Query: 3153 RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMF 3212
RQ+ LE ++ +A+E E ++ + I++QLA +
Sbjct: 1349 EAVRRQKLLEQSI-----------------QSAQETEKSLHLIQESLTFIDKQLA---AY 1388
Query: 3213 QKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA-- 3270
++VD QM + IQS D+ E +EE+ + K+ AQR+
Sbjct: 1389 IADKVDAAQMPQEAQK------IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQ 1435
Query: 3271 ------QLQEALLHC------GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3318
+LQ+ + F+ L+ L + + + + S E +VV++Q+
Sbjct: 1436 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1495
Query: 3319 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3378
L + L + K+ V+M+ G +I Q + + +++ ++ +L+ + EL +K R+
Sbjct: 1496 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1555
Query: 3379 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3438
+QLE L L+++ + ++++L+ T+ +L V + + ++ KA +++IE
Sbjct: 1556 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1615
Query: 3439 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 3498
+ ++G++L ++ E ++ +K+ L + + + R LL + +
Sbjct: 1616 QKVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME 1674
Query: 3499 LFGEDEVEVLNWLAEVEDKLSSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 3556
F ++ + W+ + + L K K+DVL R L E+ + + VD
Sbjct: 1675 TFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTR 1727
Query: 3557 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYE 3614
L+ L++ ++ + R+A I+ + + KA L++ Q + Q E
Sbjct: 1728 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1787
Query: 3615 ELTGWLRE---VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVN 3665
L +++ ++EE + + QR L++ + + R + +
Sbjct: 1788 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1847
Query: 3666 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQ 3720
AL +L R ++ L+ +S QYK +D + + +D+I+ + R ++ +
Sbjct: 1848 TKHNALKDLRSQRRKKALE--ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK 1905
Query: 3721 AADAELAWVAETKRKLMALGPIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHR 3777
D EL ++K L +R + + + A + V+ I + + ++ F+
Sbjct: 1906 EIDREL------QKKKEELNAVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ- 1957
Query: 3778 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 3837
F Q ++E+T ++ + + + + + + +S
Sbjct: 1958 ---FRRLNFAQIHTVREETMMVMTEDMPLEI------------SYVPSTYLTEITHVSQA 2002
Query: 3838 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEE 3896
+ E L+ A D E L +Q+E ++ +++S+ + ID + K L+ P E
Sbjct: 2003 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 2062
Query: 3897 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 3956
++E + + + ++ + + R D +V + + FH I+ + L L
Sbjct: 2063 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFL 2119
Query: 3957 RMPPLIPA--EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4014
R IP E K + + + + + + Q L GEE+I +S D +
Sbjct: 2120 RKTQ-IPENWEHAKYKWYLKELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI--- 2172
Query: 4015 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4074
+Q+KL + W+++ + +R+ + + + +F D+ + +++ +I
Sbjct: 2173 -LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE 2231
Query: 4075 PGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEM 4132
PG + + K+++E + + EE L+ + G ++ + E+ ++ + +
Sbjct: 2232 PGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2290
Query: 4133 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4192
N W +++ E+ ++E ++ Q + L+ + + L++ ++ L P+ L
Sbjct: 2291 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYN 2347
Query: 4193 DQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKK--ATDETDRDI---------IRE 4237
E ++E ++ V +Q ++E++ +G+ + K+ AT R + +
Sbjct: 2348 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNR 2407
Query: 4238 PLTELKHLWENLG-----------------------EKIAHRQHKLEGALL----ALGQF 4270
L EL+ +L ++ A + ++ +L+ AL F
Sbjct: 2408 LLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADF 2467
Query: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4330
A EL WL+ ++++ +QR + GD + I + K D+ + +E + A
Sbjct: 2468 NRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 2527
Query: 4331 ELLESSAGDDASS-LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4389
L ++ +A + + R+E + W+ V + + R QQL L+ + + E+
Sbjct: 2528 NLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQV 2587
Query: 4390 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4449
L + ++L + K + ++++ +L L+ + +T + + L LL +
Sbjct: 2588 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSAD 2646
Query: 4450 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 4509
K + W + ++ ER++ LEE L +F L++F+ WLT AE + N+
Sbjct: 2647 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV 2706
Query: 4510 ---ASPPSLILNT---VLSQIEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVL 4562
A+ +L V +++ + E+ AH D LD+ + L+ L D VL
Sbjct: 2707 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 2766
Query: 4563 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 4622
++ L ++ +W ++ ++S+ L+ + + K+ H + ++L+ WL+ + L + I
Sbjct: 2767 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPI 2826
Query: 4623 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--------------KEKTLLPE 4668
D ++ Q H+ F++ L K+PV +T+ T R + + L PE
Sbjct: 2827 GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE 2886
Query: 4669 D-SQKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 4723
+ +Q + L EV +W+ + S + Q K++E L + +A L L + E
Sbjct: 2887 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2946
Query: 4724 PQLAEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 4781
QPV GDL D + + ++ K + E+ V + R+L + +
Sbjct: 2947 VIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 3005
Query: 4782 KGQLQELSTRWDTVCKLSVSKQSRLEQ 4808
L++L+TRW L V+ + R+ Q
Sbjct: 3006 LSTLEDLNTRWKL---LQVAVEDRVRQ 3029
Score = 325 bits (833), Expect = 8e-88
Identities = 518/2775 (18%), Positives = 1115/2775 (40%), Gaps = 293/2775 (10%)
Query: 2270 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL---VEEINCKGTSL 2326
++F L E+E ++ +T+ LE+ + L S D ++G + VE + + +
Sbjct: 320 KSFGSSLMESEVNLDRYQTA-----LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 374
Query: 2327 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2386
E +M++TA QG+ G+IL +G+ G + + TE+Q M+ +N ++E L
Sbjct: 375 EGYMMDLTA--HQGRVGNILQLGSKLIGT--GKLSEDEETEVQEQMNLLNSRWECLRVAS 430
Query: 2387 HERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2446
E+Q +L +L M+ +++ + WL EE + M+ E +K Q + +K
Sbjct: 431 MEKQSNLHRVL--MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVL 488
Query: 2447 LAELEQNSPKIQK------VKEALAGLLVTYPNSQE----AENWKKIQEELNSRWERATE 2496
+LEQ ++ V + +G T ++ + W I RW +
Sbjct: 489 QEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 548
Query: 2497 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQF 2555
+ + QR EE C +A WL EKE + + D N + + Q++
Sbjct: 549 ILLKWQRLTEEQ-----CLFSA------WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV 597
Query: 2556 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 2615
+ + E ++Q +L Q +L+ + S+ T + + L + + W L KL ++Q
Sbjct: 598 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSV-TQKTEAWLDNFARCWDNLVQKLEKSTAQ 656
Query: 2616 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSV-----QSAISTQPEAVKQQLEETSEIRS- 2669
I QA+ +TQ + E V V R + Q + P K+Q+ SEIR
Sbjct: 657 ISQAVT-TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 715
Query: 2670 ---DLEQLDHEVKEAQTLCD--ELSVLIGEQYLKD-------------ELKKRLETVALP 2711
D+ +L + ++ + E ++ E D E ++L+ +
Sbjct: 716 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 775
Query: 2712 LQGL------EDLAADRINRLQAALASTQ-QFQQMFDELRTWLDDK--------QSQQAK 2756
Q L E + AD I + L S +F Q+ E WL+ + Q QQ +
Sbjct: 776 AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 835
Query: 2757 NCPISA----KLE--------RLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 2804
+A K++ ++SQL+ ++ +N+ SG I +
Sbjct: 836 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---EVNRLSGLQPQIERLKIQSIALKEK 892
Query: 2805 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA--QKYQWHVEDLVPWIEDCKA 2862
G+ L V NH++++ R+ L+ +YQ + + W++ +
Sbjct: 893 GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 952
Query: 2863 KMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-EDGIR 2919
K+S +L VT D +E L +A+ + +++++S L L++ + + ++ +
Sbjct: 953 KLSIPQLSVT-DYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1011
Query: 2920 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL-EIFDALG 2978
E I ++ +L LEE +LR+ Q + ++K + L E + ALG
Sbjct: 1012 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1071
Query: 2979 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3038
K L++ R +Q ++P ++ + Q + +A + AS+L + + ++
Sbjct: 1072 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQW 1130
Query: 3039 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3098
+ Q+V + ++ LE + EM + ++E + D LQ +E
Sbjct: 1131 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1190
Query: 3099 DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ 3158
+++ + + ++ ++ + + LK+ELE L L R +
Sbjct: 1191 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1250
Query: 3159 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3218
+ LE + L+ N E + E I++ L + + D
Sbjct: 1251 KTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSED 1310
Query: 3219 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3278
Q+ L Q L D + + ++E N+RW L+++ +R L++++
Sbjct: 1311 ----NPNQIRILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI-- 1361
Query: 3279 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQI-QEQKLLQRLLDDRKATVDML 3337
+ E L + ++ I Q KV AQ+ QE + +Q L + +++ +
Sbjct: 1362 --QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM 1419
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA-- 3395
+ Q E A R +LS+ QK+L+D+ + + F + A
Sbjct: 1420 KKHN----QGKEAAQR----------------VLSQIDVAQKKLQDVSMKFRLFQKPANF 1459
Query: 3396 ----EPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3451
+ L + L E + +Q Q+ L + + ++V +K G+
Sbjct: 1460 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1519
Query: 3452 SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL 3511
+ L E++ +L+ Y+E+ + + L++ L +R ++ + WL
Sbjct: 1520 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1579
Query: 3512 AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 3571
A + +L+ + L + A A +EI +K ++ + G+AL K G++
Sbjct: 1580 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKE 1638
Query: 3572 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 3631
L+++KL + + + +T + + L L + ++ F + +T W+ + + L S
Sbjct: 1639 TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE 1698
Query: 3632 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 3691
+ P Q + K LK E+ + R +D+ + + L+ R+ ++ +S+ N
Sbjct: 1699 KKKPQ-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 1753
Query: 3692 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA 3751
++ +S I + + ++ +Q+ ++++ + E + G E+D
Sbjct: 1754 HRFAAISHRI--KTGKASIPLKELEQF----NSDIQKLLEPLEAEIQQGVNLKEEDFNKD 1807
Query: 3752 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 3811
+ + ++++ D++ + + E ++ ++ K + L ++ A+ L S
Sbjct: 1808 MNEDNEGTVKELLQRGDNLQQRITD---------ERKREEIKIKQQLLQTKHNALKDLRS 1858
Query: 3812 ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES 3871
+R + Q+ ++L +++ +A LP P D ++++ E+++ +E
Sbjct: 1859 QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEE 1917
Query: 3872 IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQ-----------IKEE--- 3917
+ + + L + G + + P + ++ +++++ E+ +AQ ++EE
Sbjct: 1918 LNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKRWREIESKFAQFRRLNFAQIHTVREETMM 1975
Query: 3918 VRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNK 3977
V + L+ + ST +TE + +LE + L++ P L + + + + K
Sbjct: 1976 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA----PDLCAKDFEDLFKQEESLK 2031
Query: 3978 SATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEER 4037
+ L++ + + + + + ++ ++Q+ L Q+ F WE + ++R
Sbjct: 2032 NIKDSLQQSSGRIDIIHSKKTAALQSATPVER----VKLQEALSQLDFQWEKVNKMYKDR 2087
Query: 4038 EIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET---IKE 4094
+ +F +E +F YD+ + + + + + P + E A+ +KE
Sbjct: 2088 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKE 2139
Query: 4095 ETDGLHEELEFIRIL---GADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE 4151
DG+ + +R L G ++I +T+ +++ + +N W+ + K +R ++LE
Sbjct: 2140 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 2199
Query: 4152 DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE 4211
+ ++Q L WL+ + ++P +K++L ++K E+ +Q
Sbjct: 2200 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 2258
Query: 4212 MEKLNHQGELMLKKAT-DETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270
+++LN G +L A ++D + L + W + + +Q ++E + LGQ
Sbjct: 2259 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2318
Query: 4271 QHALEEL-------MSWLTHTEELLDA--QRPISGDPKVIEVELAKHHVLKNDVLAHQAT 4321
+ LE+L + WL+ L+ Q G V E E+A V A Q
Sbjct: 2319 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPD 2370
Query: 4322 VETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV---LQKTEEREQQLQSTLQQAQG 4378
VE + G L + ++ +LE ++ W++V LQ+ ++ L L
Sbjct: 2371 VEEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 2428
Query: 4379 FHSEI----------EDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4428
++ ++ + M S L P A +L + L Q+ +
Sbjct: 2429 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2488
Query: 4429 -------ETYNQLLDKGRLML-------------------LSRDDSGSGSKT--EQSVAL 4460
E N+++ K + + L S ++T +
Sbjct: 2489 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 2548
Query: 4461 LEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTV 4520
++ +W V ++ R+ +L E L +T++ + +E L A L ++ +
Sbjct: 2549 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 2608
Query: 4521 LSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQR 4580
+I E K A ++ + + + +L D + + ++ + W + +R
Sbjct: 2609 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 2668
Query: 4581 SIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD------SELEISNDPDKIKLQLS 4634
ER +L++ + +QF +K + WL +AE+ + + + D +K +
Sbjct: 2669 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2728
Query: 4635 KHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
+ ++ Q + VY + + +D+ L L + KW + KS+
Sbjct: 2729 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2788
Query: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG 4754
+ LE + + +LQ L+ WL + +L+ P+ GD V D H+ F++EL
Sbjct: 2789 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 2848
Query: 4755 KRTGTV-------------------QVLKRSGRELI--ENSRDDTTWVKGQLQELSTRWD 4793
+ + + L + REL E +++ T ++ Q +E++T W+
Sbjct: 2849 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 2908
Query: 4794 TVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDT 4853
+ S Q ++++ L++ + ++ L L +AE + D LID+
Sbjct: 2909 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDS 2962
Query: 4854 HKEFMKKVEEKRVDV 4868
++ ++KV+ R ++
Sbjct: 2963 LQDHLEKVKALRGEI 2977
Score = 322 bits (826), Expect = 5e-87
Identities = 541/2849 (18%), Positives = 1142/2849 (40%), Gaps = 300/2849 (10%)
Query: 2332 EITAPDSQG--KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEK-LGGVLHE 2388
+IT +QG +T S P S + Y T D T + +K G L E
Sbjct: 269 QITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLME 328
Query: 2389 RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2448
+ +L +EEV L WL S E+ L++ +S+ E VK Q +++ ++
Sbjct: 329 SEVNLDRYQTALEEV-------LSWLLSAEDTLQAQGEISNDV--EVVKDQFHTHEGYMM 379
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEE---LNSRWERATEVTVARQRQL 2505
+L + ++ + + + L+ T S++ E ++QE+ LNSRWE ++ +Q L
Sbjct: 380 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWECLRVASMEKQSNL 437
Query: 2506 EESASHLACFQAAESQLRPWLMEKELMMGVLG--PLSIDPNMLNAQKQQVQFMLKEFEAR 2563
L + E L WL + E + PL D L Q QQ + + ++ E
Sbjct: 438 HRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQE 495
Query: 2564 RQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKS 2623
+ + L + GD + T+ ++++L+ + +W + R
Sbjct: 496 QVRVNSLTHMVVVVDESSGDHA--TAALEEQLKVLGDRWANICRWTEDR----------- 542
Query: 2624 TQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 2683
LLQD+ K + + + + SA ++ E ++ T K+
Sbjct: 543 ---WVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTG------------FKDQNE 587
Query: 2684 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDEL 2743
+ L L LK +L+K+ +++ +DL + N+ + TQ+ + D
Sbjct: 588 MLSSLQKLA---VLKADLEKKKQSMGKLYSLKQDLLSTLKNK-----SVTQKTEAWLDNF 639
Query: 2744 -RTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 2802
R W + Q + IS + Q L + + ++ + +++V + L
Sbjct: 640 ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVME-TVTTVTTREQILVKHAQEEL-PP 697
Query: 2803 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKA 2862
PP ++KR + T D + R ++ + +L WI +A
Sbjct: 698 PPPQKKRQI-----------------TVDSEIR--------KRLDVDITELHSWITRSEA 732
Query: 2863 KMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL--LEILNSAADILIN---SSEADEDG 2917
+ + + S L+ K E EK L+ + +A L+ + + D
Sbjct: 733 VLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADS 792
Query: 2918 IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDAL 2977
I+ +N + L + LE + F + +E+ A++ L+I
Sbjct: 793 IKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQLEQMTTTAENWLKIQPTT 851
Query: 2978 GSQACSNKNLEKLRAQQEV--LQALEPQVDYLRNFTQGLVE--DAPDGSDASQLLHQAEV 3033
S+ + K+ K+ + EV L L+PQ++ L+ + L E P DA +
Sbjct: 852 PSEPTAIKSQLKI-CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHF 910
Query: 3034 AQQEFLEVKQRVNSGCVMMENKLEGIGQF--HCRVREMFSQLADLDDELDGMGAIGR--- 3088
+Q F +V+ R E +L+ I R +E S + + + +I +
Sbjct: 911 -KQVFSDVQAR--------EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSV 961
Query: 3089 -DTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQC 3147
D + ++ ++ +++ + + + + + M ++ + + E E + +
Sbjct: 962 TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRW 1021
Query: 3148 GKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3207
KL+ + ++LE + ++ ++ L + +W + EI+ +QL
Sbjct: 1022 KKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLK 1081
Query: 3208 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3267
++ + + +Q L VN GQ + A + LE +++E+N +W+ + ++V
Sbjct: 1082 QCRLLVSD-IQTIQPSLNSVNEGGQKIKNEAEPEF-ASRLETELKELNTQWDHMCQQVYA 1139
Query: 3268 RIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV---VKAQIQEQKLLQ 3324
R L+ L Q L + W+ EE + EYK ++ ++E K +
Sbjct: 1140 RKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLER---DFEYKTPDELQKAVEEMKRAK 1196
Query: 3325 RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDI 3384
++A V +L + A +E + +LE+L + + L ++ + K LE++
Sbjct: 1197 EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV 1256
Query: 3385 LVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3444
+ E + +L+ E KL +E + +I + + +LE + + + +
Sbjct: 1257 WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL---DSLENLMRHSEDNPN 1313
Query: 3445 QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDE 3504
Q + Q+L+ +++E++++ +R+ E+ + R+ LL+Q++ +A+ E
Sbjct: 1314 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQET-EKS 1370
Query: 3505 VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL-L 3563
+ ++ DK + ++ D Q A + ++ + + ++++ K+ Q
Sbjct: 1371 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI--QSDLTSHEISLEEMKKHNQGKEA 1428
Query: 3564 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 3623
Q ++ + Q+KL + ++ + Q F+ +E L EV
Sbjct: 1429 AQRVLSQIDVAQKKLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEV 1473
Query: 3624 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 3683
+ L +S E + L K + E + ++ V + R +++ + L
Sbjct: 1474 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1533
Query: 3684 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 3743
D+ V+ Y + + +R +++ ++ S++ + + W+A T +L +
Sbjct: 1534 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1593
Query: 3744 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 3803
+++ KA +I + K + + +E+ GE KTVL +K E+L++
Sbjct: 1594 GMPSNLDSEVAWGKATQKEIEKQKVHLKSI----TEV----GEALKTVLGKK-ETLVE-- 1642
Query: 3804 EAISLLNSERYARLERAQVLVNQFWETYEELSPW---IEETRALIAQLPSPAIDHEQLRQ 3860
+ +SLLNS A RA+ +N E + + + ++ I Q + + E+ +
Sbjct: 1643 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1702
Query: 3861 QQEE--MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGE----MVEEKYQKAENMYAQI 3914
QQ+E +++L+ + + +P +D Q L G+ +VE + + + +A I
Sbjct: 1703 QQKEDVLKRLKAELNDIRPKVDSTRD---QAANLMANRGDHCRKLVEPQISELNHRFAAI 1759
Query: 3915 KEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE-NLSSRLRMPPLIPAEVDKIRECI 3973
++ +A ++ +F+ I+ +LE LE + + + E D ++
Sbjct: 1760 SHRIKT-----GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK-----EEDFNKDMN 1809
Query: 3974 SDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKAR 4033
DN+ EL +RG+ L Q + +EI+ K + +K
Sbjct: 1810 EDNEGTVKEL----------LQRGDNL---QQRITDERKREEIKIKQQLLQTKHNALKDL 1856
Query: 4034 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIK 4093
+R K L++ ++ LL + D + + L P D IK+ + K
Sbjct: 1857 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKK 1915
Query: 4094 EETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN-----KTWKERLE 4148
EE + + + E + GA + + + + + I+ + LN +E +
Sbjct: 1916 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1975
Query: 4149 KLEDAMQAAVQYQDTL---------QAMFDWLDNTVIKLCTMPPV-GTDLNTVKDQLNEM 4198
+ + M + Y + QA+ + V +L P + D + Q +
Sbjct: 1976 VMTEDMPLEISYVPSTYLTEITHVSQALLE-----VEQLLNAPDLCAKDFEDLFKQEESL 2030
Query: 4199 KEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQH 4258
K K + Q ++ ++ + L+ AT +R ++E L++L WE + + RQ
Sbjct: 2031 KNIKDSLQQSSGRIDIIHSKKTAALQSATP-VERVKLQEALSQLDFQWEKVNKMYKDRQG 2089
Query: 4259 KLEGALLALGQFQHALEELMSWLTHTEELL-DAQRPISGDPKVIEVELAKHHVLKNDVLA 4317
+ + ++ +F + ++ WLT E+ L Q P + + + L + L++ +
Sbjct: 2090 RFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQ 2146
Query: 4318 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4377
Q V T+N G E+++ S+ DAS L+ +L ++N W+ V ++ +R+++L+
Sbjct: 2147 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2206
Query: 4378 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4437
F ++ +F+L L ++ +++ G + +E+L+ L +L ++ QL +
Sbjct: 2207 EFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNET 2265
Query: 4438 GRLMLLSRDDSGSGS-KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4496
G +L+S S K E + +W VS + E++ ++E + + + L++
Sbjct: 2266 GGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2325
Query: 4497 -------INWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 4549
+ WL+ L I + P+ ++E ++ V A + + E+ G
Sbjct: 2326 EEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQ 2379
Query: 4550 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQ------------------------------ 4579
L +K +K L + S W+ V +
Sbjct: 2380 HL--YKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2437
Query: 4580 -----------RSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 4628
+E SL F+ AW +L DWL + + S+ + D +
Sbjct: 2438 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2497
Query: 4629 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 4688
I + K K + L ++P + I + LK KT E + + + ++++WD V
Sbjct: 2498 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2557
Query: 4689 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 4748
R+ +L E L S Q+++A + L + +L + +D + + K
Sbjct: 2558 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2617
Query: 4749 FQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLE 4807
K+L + V V +L+ + S DDT V + ++ W ++ K +++ LE
Sbjct: 2618 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2677
Query: 4808 QALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTH--KEFMKKVEEKR 4865
+ + + F + L WL+EAE T L D T + L D+ KE MK+ ++ +
Sbjct: 2678 ETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2734
Query: 4866 VDVNSAVAM--------GEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 4917
++ + + +++ ++ D ++ + + ++ E+ + + LE
Sbjct: 2735 GEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA 2794
Query: 4918 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 4977
+ + L+ELL W+Q + L + Q PI + V+ H+ F E+ K+P
Sbjct: 2795 SSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEP 2852
Query: 4978 DVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP--TPPPMPILSQSEAKNPRINQLS 5035
+ +E E+ G K +P PP + + + +++
Sbjct: 2853 VI--------MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVN 2904
Query: 5036 ARWQQVWLLALERQRKLNDALDRLEELKE 5064
W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 2905 TEWEKLNLHSADWQRKIDETLERLQELQE 2933
Score = 296 bits (757), Expect = 5e-79
Identities = 510/2885 (17%), Positives = 1162/2885 (40%), Gaps = 305/2885 (10%)
Query: 1936 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 1995
++Q + + + +W+ + E ++ +++D V+++Q T + +L HQ V +
Sbjct: 335 RYQTALEEVLSWLLSAEDTLQA--QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 392
Query: 1996 KVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLE 2055
++ ++ + VQE + + S ++ L + E+ S L + + Q+ + L+
Sbjct: 393 QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN--QKLK 450
Query: 2056 SLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFM 2113
L + + E+ + L + ++ + + L++D+ +++ + + MV
Sbjct: 451 ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVD 510
Query: 2114 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQF 2169
E++ A L+ +L + R+ +C +++ L+ +L + + S L +
Sbjct: 511 ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 570
Query: 2170 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2229
+ +++ +G + ++ Q++ L ++E +++++ L L +L S + Q
Sbjct: 571 EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 630
Query: 2230 HQDR------------VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL- 2276
+ VQ L K ++ + V + S Q + E V T ++ L
Sbjct: 631 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQP--SLTQTTVMETVTTVTTREQILV 688
Query: 2277 KETEGSIPPTETSMSAK-----ELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSL 2326
K + +PP + E+ K+++ + L W ++ V + I K +
Sbjct: 689 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 748
Query: 2327 ENLIMEITAPDS---------QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNL 2377
+L ++ A + Q + S V V + K +E +N
Sbjct: 749 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE------QLNS 802
Query: 2378 KYEKLGGVLHER------QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2431
++ + +L ER Q ++ A N+++++ + + WL+ + ++P+
Sbjct: 803 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP---------TTPS 853
Query: 2432 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL---N 2488
+ +K+Q + K + L P+I+++K L ++ + + +
Sbjct: 854 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL------KEKGQGPMFLDADFVAFT 907
Query: 2489 SRWERATEVTVARQRQLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNML 2546
+ +++ AR+++L+ L +Q S +R W+ + E + + D ++
Sbjct: 908 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 967
Query: 2547 NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVEL 2605
+ ++Q + + ++ L+ + + P ++S + Q E + I +W +L
Sbjct: 968 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS---RKYQSEFEEIEGRWKKL 1024
Query: 2606 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 2665
+ +L ++++ + K + Q +Q L + + V L + E +K+QL++
Sbjct: 1025 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1084
Query: 2666 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELK----KRLETVALPLQGLEDLAAD 2721
+ SD++ + + SV G Q +K+E + RLET L D
Sbjct: 1085 LLVSDIQTIQPSLN---------SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1135
Query: 2722 RI----NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEF 2777
++ L+ L T Q+ E+ W+ + + + + LQ ++E +
Sbjct: 1136 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1195
Query: 2778 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 2837
++ Q +++ S++ PP ++ L+ +L L +++ L + + L+
Sbjct: 1196 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQE-ALKKELETLTTNYQWLCTRLNGKCKTLE 1254
Query: 2838 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-KAMLNEVEKRRSL 2896
+ + ++E W+ + + K+ + S +L S + ++ E +
Sbjct: 1255 EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQ 1314
Query: 2897 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 2956
+ IL A L + DE I +E N + EE + LE+ Q +E ++S
Sbjct: 1315 IRIL---AQTLTDGGVMDEL-INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1370
Query: 2957 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3016
I++ + QL + + + + + ++ + Q L + E ++ ++ QG
Sbjct: 1371 LHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-- 1426
Query: 3017 DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADL 3076
A ++L Q +VAQ++ +V + + F R++E L ++
Sbjct: 1427 -----EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANFEQRLQESKMILDEV 1473
Query: 3077 DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3136
L + + + +QSQ+ + +K ++E R +++++ T + L
Sbjct: 1474 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1533
Query: 3137 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3196
+ AL +L + R++QLE L +++ L + A + + V
Sbjct: 1534 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1593
Query: 3197 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3256
++ ++A K QKE ++ ++ L+ + +G+ L GK + +E + +N+
Sbjct: 1594 GMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKETL--VEDKLSLLNS 1650
Query: 3257 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI--ANQKPPSAEYKVVK 3314
W + + + + L E H F ++ + W+ + L+ + +K P + V+K
Sbjct: 1651 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLK 1710
Query: 3315 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL---- 3370
L+ L+D + VD + + + + R+ + Q+ L R+ +
Sbjct: 1711 R-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1763
Query: 3371 -LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI-IR 3428
KA+ K+LE F S +K L EP+ A+IQQ + ++
Sbjct: 1764 KTGKASIPLKELEQ-----------------FNSDIQKLL---EPL---EAEIQQGVNLK 1800
Query: 3429 HKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3486
+ +D+ E++ V + ++ G +L +T ++ + K LQ +++ ++D ++
Sbjct: 1801 EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQR 1860
Query: 3487 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKDFKQDVLHRQHADHL 3539
+ + ++L L ++E KL+S+ +K+ +++ ++
Sbjct: 1861 RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK----- 1915
Query: 3540 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-----KTRYADITVTSSK 3594
EE+ ++ + ++G A+ + T ++ +++ + +A I +
Sbjct: 1916 ---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1972
Query: 3595 ALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE 3649
+ + + L + STY ++ L EVE+ L + E + + ++ K
Sbjct: 1973 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 2032
Query: 3650 LKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 3709
+K + + +D ++ A L+ R L + +S + Q++ V+ R D
Sbjct: 2033 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2092
Query: 3710 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ-VQKAFSIDIIRHKD 3768
++++ +++ W+ E ++ L ++ ++ A+ + K I + +
Sbjct: 2093 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKWYLKELQDGIGQRQT 2149
Query: 3769 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 3828
+ L + EI + ++LQEK SL +++ + S+R RLE + ++++F
Sbjct: 2150 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2209
Query: 3829 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 3888
E W+EE IA +P +QL+++ E+++ L E + + + +L + G
Sbjct: 2210 RDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGP 2268
Query: 3889 L---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 3945
+ ++PEE + +E K ++ + ++ + ++ E +Q + + K+E +
Sbjct: 2269 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQIKDLGQLEKKLEDL 2325
Query: 3946 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4005
E L +L L + P+ +++ N+ ++++ + + +A + EE++ + Q
Sbjct: 2326 EEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2379
Query: 4006 GADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4064
K+ A + ++ KL+ + W+ + +E K D+A LTTI
Sbjct: 2380 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK-----------QPDLAPGLTTIG- 2427
Query: 4065 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4124
SP +++ Q V ET K E
Sbjct: 2428 --------ASPTQTVTLVTQPVVTKETA---------------------------ISKLE 2452
Query: 4125 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4184
+ S+ A + N+ W E + DWL + + +
Sbjct: 2453 MPSSLMLEVPALADFNRAWTE---------------------LTDWLSLLDQVIKSQRVM 2491
Query: 4185 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4244
DL + + + + K ++ Q++ ++E+L + + K +++ R II + + +++
Sbjct: 2492 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2551
Query: 4245 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4304
W+ + E + +R+ +L L Q+ A EE L L++ + I+ +
Sbjct: 2552 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2611
Query: 4305 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4364
+ + L D+ Q V+ N +LL + DD + E +N W S+ ++ E
Sbjct: 2612 ITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE 2671
Query: 4365 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQLDTHM 4418
RE L+ T + Q F ++E FL LT E+ + A++ L ++ +E +
Sbjct: 2672 REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQ 2731
Query: 4419 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4478
+L +++A + Y+ L + + +L S + S ++ + + KW + K +S
Sbjct: 2732 DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSH 2791
Query: 4479 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 4538
LE + + SLQE + WL L + L+ +P V Q + H+ F E+
Sbjct: 2792 LEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2851
Query: 4539 DQII-------------------ELDQTGNQLKFLSQKQDVV-LIKNLLVSVQSRWEKVV 4578
I+ +L Q +L + Q+V L++ V + WEK+
Sbjct: 2852 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2911
Query: 4579 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 4638
S + R +D+ +R ++ EA +L L AE S + D + L H E
Sbjct: 2912 LHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG---DLLIDSLQDHLE 2968
Query: 4639 FQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRDKWDTVCGKSVERQH 4696
K L G+ P+ + ++ T L + + L ++ +W + +R
Sbjct: 2969 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVR 3028
Query: 4697 KLEEA 4701
+L EA
Sbjct: 3029 QLHEA 3033
Score = 241 bits (614), Expect = 2e-62
Identities = 570/2964 (19%), Positives = 1185/2964 (39%), Gaps = 456/2964 (15%)
Query: 549 KAEPLTKATHSSSTSWFRKPMTRAELVA-------ISSSEDEGNL----RFVYELLSWVE 597
K+ T+A + +++ R P L A S E E NL + E+LSW+
Sbjct: 289 KSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLL 348
Query: 598 EMQMKLE-RAEWGNDLPSVELQLETQQHIHT----------SVEELGSSVKEARLYEGKM 646
+ L+ + E ND+ V+ Q T + ++ +LGS + + GK+
Sbjct: 349 SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKL----IGTGKL 404
Query: 647 SQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELI-----WLNEKEE 701
S++ T E + L +++ L+ S M +LH+ + + + WL + EE
Sbjct: 405 SEDEETEVQEQMNLLNSRWECLRVAS---MEKQSNLHRVLMDLQNQKLKELNDWLTKTEE 461
Query: 702 -------EELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAK 754
E L D D + + L +LE++Q SL ++ +
Sbjct: 462 RTRKMEEEPLGPDLEDLKRQVQQHK----VLQEDLEQEQVRVNSLTHMVVVVD------E 511
Query: 755 QTVEAYSAAVQSQLQWM----KQLCLCVEQH---VKENTAYFQFFSDARELES-FLRNLQ 806
+ + +AA++ QL+ + +C E +++ +Q ++ + L S +L +
Sbjct: 512 SSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKE 571
Query: 807 DSIKRKYSC---DHNTSLSRLEDL--LQDSMDEKEQ----LIQSKSSVASLVGRSKTIVQ 857
D++ + ++ D N LS L+ L L+ +++K+Q L K + S + ++K++ Q
Sbjct: 572 DAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL-KNKSVTQ 630
Query: 858 LKPRSPDHVL-----------KNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVI 906
D+ K+T + Q +T E V + T+ +++
Sbjct: 631 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETV---TTVTTREQIL 687
Query: 907 SPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKD 966
E + P PP K I + S + + +L V+ L SW + +
Sbjct: 688 VKHAQEELPPP-----PPQKKRQITVDSEIRK----------RLDVDITELHSW--ITRS 730
Query: 967 LDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLR-LEEEVEAC 1025
++Q+ R + ++ D L++ +++ A++ R L++ +
Sbjct: 731 EAVLQSPEFAIFRK-------------EGNFSD-LKEKVNAIEREKAEKFRKLQDASRSA 776
Query: 1026 KARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ 1085
+A + ++ N D +I+ E+ R ++ Q L S R + +Q
Sbjct: 777 QALVEQMVNEGVNAD--------------SIKQASEQLNSRWIEFCQ-LLSERLNWLEYQ 821
Query: 1086 DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPT-LRSELNLLVEKMDH 1144
+N + Q LQQL + ++ +++L P++ S PT ++S+L + ++++
Sbjct: 822 NNIIAFYNQ------LQQL----EQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNR 871
Query: 1145 VYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQE-EVVLADLSALEAHWSTL--- 1200
+ GL + +LK + ++ + + + + + V +D+ A E T+
Sbjct: 872 LSGLQP-QIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDT 930
Query: 1201 -------------RHWLSDVKDKNSV--FSVLDEEIAKAKV------------------- 1226
R W+ + K S+ SV D EI + ++
Sbjct: 931 LPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYY 990
Query: 1227 ---VAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRAC 1283
++MS+ P +YQ + +++ RW ++ +QL +LE L +
Sbjct: 991 LSTTVKEMSKKAPSEIS--RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1048
Query: 1284 HGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQY 1343
TL KW+ E + P DS +L +QL Q L ++I+ Q L+ + Q+
Sbjct: 1049 IQTLKKWMAEVDVFLKEEWPALG-DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1107
Query: 1344 STIVK-DYELQLMTYKAFVESQ-----QKSPGKRRRMLSSSDAITQEFMDLRTRYTALVT 1397
+ ++ +L T + +Q Q+ ++ + + DL + +
Sbjct: 1108 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1167
Query: 1398 LTTQHVK-----YISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS 1452
++++ D L++ EE K +EE Q+ KVK L V+++ A +
Sbjct: 1168 AEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1227
Query: 1453 ETKESTDIEKAILEQQVLSEELTTKKEQVSEA----------IKTSQIFLAKHGHKLSEK 1502
KE +E Q L L K + + E ++ + +L + KL
Sbjct: 1228 LKKE---LETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTT 1284
Query: 1503 EK-----KQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE 1557
E ++ISE L++L + + NQ++ L L T+ + + N ++LE
Sbjct: 1285 ENIPGGAEEISEVLDSLENLMRH-SEDNPNQIRILAQTL---TDGGVMDELIN---EELE 1337
Query: 1558 DLCS-WVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKD---- 1612
S W E A+ + + +Q + + Q+ + L +Q+ + A + D
Sbjct: 1338 TFNSRWRELHEEAV--RRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1395
Query: 1613 --IEGFMEENQTKLSPRELTALREKLH-QAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
+ ++ Q+ L+ E++ K H Q KE + + + VAQK+L++ V+ +
Sbjct: 1396 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQD-VSMKFRLFQ 1454
Query: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGY- 1728
+ + + L E+K +D ++ +LP +E S+E+ + + +
Sbjct: 1455 KPANFEQRLQESKMILD--------------EVKMHLPALET---KSVEQEVVQSQLNHC 1497
Query: 1729 MGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQK 1788
+ + ++ ++ + EM+ ++++ ++Q E + L ++
Sbjct: 1498 VNLYKSLSEVKSEVEMVIKTGRQIVQKKQT---------------------ENPKELDER 1536
Query: 1789 LGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSP 1848
+ LK Y+ A+ +Q++ +K ++ WL ++ EL P
Sbjct: 1537 VTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMP 1596
Query: 1849 ETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKD 1908
L S + + +++ K L+ +T G+ + + GK+ + LV+DKL
Sbjct: 1597 SNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV-----LGKKET----LVEDKLSL 1647
Query: 1909 ATERYTALHSKCTRLGSHLNMLLG-QYHQ--FQNSADSLQAWMQACEANVEKLLSDTVAS 1965
+ A+ S R LN+LL Q H F + D + W+ + LL ++
Sbjct: 1648 LNSNWIAVTS---RAEEWLNLLLEYQKHMETFDQNVDHITKWI----IQADTLLDESEKK 1700
Query: 1966 DPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDH-RHVQETTDSILS 2024
P Q++ K+L+ EL + + V+ + A ++M G DH R + E S L+
Sbjct: 1701 KP---QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELN 1753
Query: 2025 H-FQSLSYSL-AERSSLLQKAIAQ----SQSVQESLESLLQSIGEVEQNLEGKQVSSLSS 2078
H F ++S+ + ++S+ K + Q Q + E LE+ +Q +++ K ++ +
Sbjct: 1754 HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1813
Query: 2079 GVIQEALATNMKLKQDIARQKSSLE-ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQ 2137
G ++E L L+Q I ++ E ++ + + A + + K E+S ++ Q
Sbjct: 1814 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1873
Query: 2138 LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQEL 2197
++ + L + +++ + LAS +P + ++I+E+
Sbjct: 1874 ---------------------YKRQADDLLKCLDDIEKKLASLPEPRDE-----RKIKEI 1907
Query: 2198 NLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASS 2257
+ E++ ++E L+ + LS G A+ + + T++Q + + RE ++
Sbjct: 1908 DRELQKKKEELNAVRRQAEGLSEDGAAMAV------------EPTQIQLSKRWREIESKF 1955
Query: 2258 CQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLL---------DD 2308
Q + F + + T ++ P E S +I H+ L D
Sbjct: 1956 AQFRRLNFAQ-IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPD 2014
Query: 2309 WASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEI 2368
+K E++ + SL+N+ DS ++ + + S + T + ++
Sbjct: 2015 LCAKD--FEDLFKQEESLKNI------KDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 2066
Query: 2369 QCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMS 2428
Q +S ++ ++EK+ + +RQ + + H + QWL E+ L+
Sbjct: 2067 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI-- 2124
Query: 2429 SPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL---LVTYPNSQEAENWKKIQE 2485
P E K K +L EL+ + Q V L ++ + +A ++
Sbjct: 2125 -PENWEHAK-----YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2178
Query: 2486 ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPN 2544
LN RW+ + R+++LEE + L+ FQ ++ WL E + + + PL
Sbjct: 2179 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEPGKEQ 2236
Query: 2545 MLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE 2604
L + +QV+ +++E R+ +QLNE +L +++ +L+ N +W++
Sbjct: 2237 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIK 2296
Query: 2605 LTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV---QSAISTQPE------ 2655
++ L + +I+ I Q ++ L+DL E++ + LS Q I QP
Sbjct: 2297 VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD 2356
Query: 2656 ------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRL---- 2705
AV+ + + EI S + L E Q + +L L E + L + L
Sbjct: 2357 VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQ 2416
Query: 2706 ---------------ETVALPLQGL--EDLAADRI---NRLQAALASTQQFQQMFDELRT 2745
+TV L Q + ++ A ++ + L + + F + + EL
Sbjct: 2417 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2476
Query: 2746 WLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPG 2805
WL + LE + + + + + L Q E ++ ++L
Sbjct: 2477 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2536
Query: 2806 EEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMS 2865
E + + +++ ++N W+E+ + +R+ +L + ++ + ++ E+ + +AK+
Sbjct: 2537 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 2596
Query: 2866 ELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED-GIRDE 2921
+ T+D +Q + +K + ++ + ++ +++ N A L+ AD+ +
Sbjct: 2597 SWKEGPYTVDAIQ--KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 2654
Query: 2922 KAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ---ESFKNIEKKVEGAKHQLEIFDALG 2978
IN + ++ + + + +LEE + L++F E F + E + L+
Sbjct: 2655 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2714
Query: 2979 SQACSNKNLEKLRAQQEVLQA-LEPQVDYLRNF---TQGLVEDAPDGSDASQLLHQAEVA 3034
+K +++L Q + LQ +E D N +Q ++ DA L + +
Sbjct: 2715 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2774
Query: 3035 QQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQ 3094
++ E++++ + +E + + H ++E+ L DDEL IG D ++Q
Sbjct: 2775 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ 2834
Query: 3095 SQ---------------------IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDL 3133
Q +E VR+FL + + L E E R + EE ++
Sbjct: 2835 KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL--EKLYQEPRELPPEERAQNV 2892
Query: 3134 LG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQ 3192
L+++ E +N + KL Q +++ TL R+++ L+ AE +
Sbjct: 2893 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2952
Query: 3193 WVVG-TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3251
VG ++ + L K + E + PL+ + VN L + L + G L +
Sbjct: 2953 QPVGDLLIDSLQDHLEKVKALRGE-IAPLKENVSHVNDLARQL-TTLGIQLSPYNLS-TL 3009
Query: 3252 EEINARWNTLNKKVAQRIAQLQEA 3275
E++N RW L V R+ QL EA
Sbjct: 3010 EDLNTRWKLLQVAVEDRVRQLHEA 3033
Score = 238 bits (606), Expect = 2e-61
Identities = 494/2777 (17%), Positives = 1066/2777 (38%), Gaps = 367/2777 (13%)
Query: 1431 VKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI 1490
++E+L W+ + Q + S E + E ++ +LT + +V ++
Sbjct: 340 LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMM--DLTAHQGRVGNILQLGSK 397
Query: 1491 FLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQN 1550
+ KLSE E+ ++ EQ+N LN + L S + L + L QN
Sbjct: 398 LIGTG--KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL---------HRVLMDLQN 446
Query: 1551 TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRAT 1604
Q+L++L W+ + E + DL L++ K LQ+D++ N T
Sbjct: 447 ---QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 503
Query: 1605 SFATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVA 1653
VV + G +EE L R R L +++ L EE +
Sbjct: 504 HMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLF 563
Query: 1654 QKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLS 1713
L E + + T K E+ + +K+ L + S G+L + + L
Sbjct: 564 SAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL---KQDLL 620
Query: 1714 GASLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ 1772
K T+ ++ + + L ++ E A+ + ++ Q + T +
Sbjct: 621 STLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT-- 678
Query: 1773 HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ-DHKEFESWL 1831
+T EQ +++ E L + K+ T+ E++K L D E SW+
Sbjct: 679 ---TVTTREQILVKHAQEE--------LPPPPPQKKRQITVDSEIRKRLDVDITELHSWI 727
Query: 1832 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 1891
RSE L+ SPE ++ +++G+FS+ R +K+ D S +
Sbjct: 728 TRSEAVLQ-------SPEF--AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 778
Query: 1892 GKEPSEIGNLVKDKLKDATERYTALHSK-CTRLGSHLNMLLGQYH--QFQNSADSLQAWM 1948
E + D +K A+E+ + + C L LN L Q + F N L+
Sbjct: 779 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMT 838
Query: 1949 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2008
E ++ + T S+P ++ QL K L+ Q +E+L K+ ++ +G+
Sbjct: 839 TTAENWLK--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERL-KIQSIALKEKGQ- 894
Query: 2009 APDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI--AQSQSVQESLESLLQSIGEVEQ 2066
+ + +HF+ + + R LQ QE++ ++ + + E
Sbjct: 895 --GPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 952
Query: 2067 NLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQG 2126
L Q+S ++++ L L+ + Q+S L V + A S + Q
Sbjct: 953 KLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQS 1012
Query: 2127 KLAEVSQRFEQL-------CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS 2179
+ E+ R+++L C + +E+ + L+K+ + + ++ F++ + L
Sbjct: 1013 EFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD 1072
Query: 2180 GNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRK 2239
+ + +Q + L +++ Q +L+++ ++ + + + ++ L
Sbjct: 1073 ----SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNT 1128
Query: 2240 DFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQ 2298
+ + + V R++ E+ +K + +W+ + E + + EL+K
Sbjct: 1129 QWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA 1188
Query: 2299 IEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNG 2358
+E +K ++ K V+ + T N ++ P +Q
Sbjct: 1189 VEEMKRAKEEAQQKEAKVKLL----TESVNSVIAQAPPVAQ------------------- 1225
Query: 2359 YHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKE 2418
++ ++ + Y+ L L+ + ++L+ + E+ +WL E
Sbjct: 1226 -------EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE 1278
Query: 2419 EVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQE 2476
LK+ + + P E + +S + + E N +I+ + + L G++ N +
Sbjct: 1279 FKLKTTE--NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEE- 1335
Query: 2477 AENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVL 2536
E NSRW E V RQ+ LE+S + + ++ L + +
Sbjct: 1336 -------LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1388
Query: 2537 GPLSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQK 2593
+D + + Q++Q L E ++H Q EAAQ +L+ QK
Sbjct: 1389 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLS-------QIDVAQK 1441
Query: 2594 ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQ 2653
+LQ ++ K+ + K +++ LQ+ + V L S +
Sbjct: 1442 KLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE 1486
Query: 2654 PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK-------DELKKRLE 2706
E V+ QL + L ++ EV E+ + G Q ++ EL +R+
Sbjct: 1487 QEVVQSQLNHCVNLYKSLSEVKSEV--------EMVIKTGRQIVQKKQTENPKELDERVT 1538
Query: 2707 TVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER 2766
+ L L +R +L+ L +++ ++ + L WL + K +
Sbjct: 1539 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1598
Query: 2767 LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS 2826
L S++ + QK + + + I GE+L + G+++ ++++L L ++W ++
Sbjct: 1599 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL--GKKETLVEDKLSLLNSNWIAVT 1656
Query: 2827 KKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM 2886
+ + + L + + + + +V+ + WI + E P Q E L R KA
Sbjct: 1657 SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAE 1715
Query: 2887 LNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS--LE 2944
LN++ R + + AA+++ N + + + + +N A++ ++ S L+
Sbjct: 1716 LNDI--RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLK 1773
Query: 2945 EMTQRLREFQESFKNIEKKVE--------------------GAKHQLEIFDALGSQACSN 2984
E+ Q + Q+ + +E +++ K L+ D L +
Sbjct: 1774 ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDE 1833
Query: 2985 KNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQR 3044
+ E+++ +Q++LQ + LR+ + A ++ HQ +++ ++ +
Sbjct: 1834 RKREEIKIKQQLLQTKHNALKDLRSQRR---------KKALEISHQWYQYKRQADDLLKC 1884
Query: 3045 VNSGCVMMENKLEGIGQ--FHCRVREMFSQLADLDDELDGM--GAIGRDTDSLQSQIEDV 3100
++ +E KL + + +++E+ +L +EL+ + A G D +E
Sbjct: 1885 LDD----IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPT 1940
Query: 3101 RLFLNK-------------------IHVLK----------LDIEASE------AECRH-- 3123
++ L+K IH ++ + +E S E H
Sbjct: 1941 QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVS 2000
Query: 3124 --MLEEEGTLDLLGL-KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND 3180
+LE E L+ L ++ E L KQ E K ++ L+ + GR++ + K
Sbjct: 2001 QALLEVEQLLNAPDLCAKDFEDLFKQ----EESLKNIKDSLQQSSGRIDIIHSKKTAALQ 2056
Query: 3181 ATTAAEEA---EAL-----QWV----------------------VGTEVEIINQQLADFK 3210
+ T E EAL QW +++I NQ L + +
Sbjct: 2057 SATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE 2116
Query: 3211 MFQKEQVDP---------------------LQMKLQQVNGLGQGLIQSAGKDCDVQGLEH 3249
F ++ P Q ++ +N G+ +IQ + K D L+
Sbjct: 2117 QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK-TDASILQE 2175
Query: 3250 DMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAE 3309
+ +N RW + K+++ R +L+E +FQ L + WL + + + + P E
Sbjct: 2176 KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE 2235
Query: 3310 YKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA--DREKITGQLESLESRW 3367
+ +K ++++ KLL L R+ + L GG + SA ++ +++K+ +L+ +W
Sbjct: 2236 QQ-LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQW 2294
Query: 3368 TE----LLSKAAARQKQLEDILVLAKQFHETAEPISDFL----SVTEKKLANSEPVGTQT 3419
+ L K + Q++D+ L K+ + E ++ L + + ++P
Sbjct: 2295 IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP 2354
Query: 3420 AKIQQQIIRHKALEEDIENHATDVHQAVK-------IGQSLSSLTSP------------A 3460
+Q+ I +A + D+E + K + + L L+S A
Sbjct: 2355 FDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRA 2414
Query: 3461 EQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL-------------FGEDEVEV 3507
+Q L+ + ++ A ++ + + A+S + F E+
Sbjct: 2415 KQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTEL 2474
Query: 3508 LNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTT 3567
+WL+ ++ + S V + ++ A +++ R+ +++ I Q L +T+
Sbjct: 2475 TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTS 2534
Query: 3568 GEEV-LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEE 3626
+E +I ++++ I+ ++ ++ + L + + +T++ EE L + +
Sbjct: 2535 NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAK 2594
Query: 3627 LATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKL 3686
L + T + I + K+L K++ + + +D N+++ LL + +
Sbjct: 2595 LESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 2654
Query: 3687 VSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR--- 3743
+ N ++ + + +R ++ + QQ+ + LAW+ E + L
Sbjct: 2655 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2714
Query: 3744 --LEQDQTTAQLQVQ-KAFSIDIIRHKDSMDELFSHRSEIFGTC-GEEQKTVLQEKTESL 3799
LE + +L Q + +I H D L + +I + G + +LQ + +++
Sbjct: 2715 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2774
Query: 3800 IQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLR 3859
++ + + + LE + + + +EL W++ +++ D ++
Sbjct: 2775 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ 2834
Query: 3860 QQQEEMRQLRESIAEHKPHIDKLLKIG---------PQLKELNPEEGEM-VEEKYQKAEN 3909
+Q + R + + +P I L+ L++L E E+ EE+ Q
Sbjct: 2835 KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTR 2894
Query: 3910 MYAQIKEEVRQRALALD-EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK 3968
+ + EEV L+ + +I E ++++ + E + L +LR +I
Sbjct: 2895 LLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQP 2954
Query: 3969 IRECISDNKSATVELEK 3985
+ + + D+ +E K
Sbjct: 2955 VGDLLIDSLQDHLEKVK 2971
Score = 211 bits (536), Expect = 2e-53
Identities = 114/231 (49%), Positives = 150/231 (64%), Gaps = 5/231 (2%)
Query: 74 DERDRVQKKTFTKWVNKHLMKVRK-HINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMR 132
DER+ VQKKTFTKWVN K K HI +L+ DL+DG L+ LLE L+G KLP+EKG R
Sbjct: 3 DEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTR 62
Query: 133 FHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESG 192
H L NV AL L+ V LVNI + DI DGN KLTLGLIW IILH+Q+ ++ + +G
Sbjct: 63 VHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAG 122
Query: 193 -DMSAKEKLLL-WTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQI-Q 249
+ EK+LL W ++ T Y + NF++ WSDG NALIH +RPDL D V Q
Sbjct: 123 LQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQ 182
Query: 250 SNRENLEQAFEVAE-RLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPK 299
S + LE AF +A +LG+ +LLD EDVD PD+KS++ Y++S++ P+
Sbjct: 183 SATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 233
Score = 196 bits (498), Expect = 5e-49
Identities = 481/2824 (17%), Positives = 1126/2824 (39%), Gaps = 356/2824 (12%)
Query: 1246 QEKGSQLQERWHRV-IAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKP 1303
QE+ + L RW + +A +E +QS L + L + + L W+ +T + ++M +
Sbjct: 413 QEQMNLLNSRWECLRVASME-KQSNLHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEE 469
Query: 1304 GQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVES 1363
D L Q+ Q L ++E+ Q +++ S + +V D
Sbjct: 470 PLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN-----SLTHMVVVVD-------------- 510
Query: 1364 QQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDAL---RRLEEEEKVV 1420
+S G ++ A+ ++ L R+ + T + D L +RL EE+ +
Sbjct: 511 --ESSGDH-----ATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLF 563
Query: 1421 E---EEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTK 1477
EK++ V K+ +T G K+ ++ ++ + VL +L K
Sbjct: 564 SAWLSEKEDAVNKI------------HTTG------FKDQNEMLSSLQKLAVLKADLEKK 605
Query: 1478 KEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA 1537
K+ + + Q L S + K ++++ A + D N +Q+L+ A
Sbjct: 606 KQSMGKLYSLKQDLL-------STLKNKSVTQKTEAWLDNFARCWD---NLVQKLEKSTA 655
Query: 1538 HQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQD 1597
Q Q Q + + + + V E+ L H Q++L + +
Sbjct: 656 -QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKH----AQEELPPPPPQKKRQITVDS 710
Query: 1598 DIQNRA----TSFATVVKDIEGFMEENQTKLSPRE--LTALREKLH----QAKEQYEALQ 1647
+I+ R T + + E ++ + + +E + L+EK++ + E++ LQ
Sbjct: 711 EIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQ 770
Query: 1648 EETRVAQKELEEAVTSALQQETEKSKAAKEL----AENKKKIDALLDWVTSVGSSGGQLL 1703
+ +R AQ +E+ V + ++ K +A+++L E + + L+W+ +
Sbjct: 771 DASRSAQALVEQMVNEGVNADSIK-QASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FY 828
Query: 1704 TNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILAT 1763
L +EQ++ + + T P + Q ++ K L Q I
Sbjct: 829 NQLQQLEQMTTTAENWLKIQPT-----TPSEPTAIKSQLKICKDEVNRLSGLQPQ-IERL 882
Query: 1764 QSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFL 1821
+ L + G L + + +A K++QT+ D L ++
Sbjct: 883 KIQSIALKEKGQG-----PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQ 937
Query: 1822 QDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQK 1881
+ +W+++SE +L + E + L + + + L +++ + ++
Sbjct: 938 ETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE 997
Query: 1882 VLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSA 1941
+ K PSEI + + ++ R+ L S+ L + + + QN
Sbjct: 998 M--------SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHI 1049
Query: 1942 DSLQAWMQACEANVEKLLSDT--VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 1999
+L+ WM A V+ L + D +L++QL KQ + +++ Q L V
Sbjct: 1050 QTLKKWM----AEVDVFLKEEWPALGDSEILKKQL---KQCRLLVSDIQTIQPSLNSVNE 1102
Query: 2000 DIMEIEGEPAPDHRHVQETT-DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2058
+I+ E P+ ET + + + + + R L+ + ++ S+Q+ L +
Sbjct: 1103 GGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMH 1162
Query: 2059 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2118
+ + + E+ + + +Q+A+ + K++ ++++ ++ E V + A
Sbjct: 1163 EWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP 1222
Query: 2119 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQFMENKSRML 2177
L+ +L ++ ++ LC + K +L+++ E+ +L + E + ++
Sbjct: 1223 VAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLK 1282
Query: 2178 ASGNQPD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQ 2235
+ N P ++I+ ++ L ED + L +T+ G +D +++ ++
Sbjct: 1283 TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD----GGVMDELINEE-LE 1337
Query: 2236 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL 2295
+ EL + R+K L+ + +ETE S+ + S++ +
Sbjct: 1338 TFNSRWRELHEEAVRRQK--------------LLEQSIQSAQETEKSLHLIQESLTF--I 1381
Query: 2296 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2355
+KQ+ + D A ++I TS E + +E +QGK +
Sbjct: 1382 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHE-ISLEEMKKHNQGKEAA----------- 1429
Query: 2356 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2415
+ Q + DV++K+ L ++ + + L + + E L LE
Sbjct: 1430 ---QRVLSQIDVAQKKLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPALE 1481
Query: 2416 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2475
+K + E V++Q L + +++ V + ++ +
Sbjct: 1482 TKS------------VEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV----QKK 1525
Query: 2476 EAENWKKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELM 2532
+ EN K++ E + + E+ R++QLE+ + + L WL ++
Sbjct: 1526 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1585
Query: 2533 MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ 2592
+ + P+ L+++ + KE E ++ + + E + + T G + V+
Sbjct: 1586 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK---KETLVE 1642
Query: 2593 KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAIST 2652
+L +N W+ +T S+ ++ + +YQ+ ++ + V + + + +
Sbjct: 1643 DKLSLLNSNWIAVT-------SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1695
Query: 2653 QPEAVKQQLEET--SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVAL 2710
+ E K Q +E ++++L + +V + L G D +K +E
Sbjct: 1696 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-----DHCRKLVEPQIS 1750
Query: 2711 PLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 2770
L + RI +A++ ++ +Q +++ L+ P+ A+++ Q
Sbjct: 1751 ELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLE----------PLEAEIQ--QGV 1797
Query: 2771 LQENEEFQKSLNQ-HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKT 2829
+ E+F K +N+ + G+ + ++ G++L + ++ ++ + L+ L
Sbjct: 1798 NLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLR 1857
Query: 2830 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAM 2886
+ R+ + + + +Y+ +DL+ ++D + K++ L D +++ L + K
Sbjct: 1858 SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEE 1917
Query: 2887 LNEVEKRRSLLEILNSAADILINSSEADEDG--IRDEKAGINQNMDAVTEELQAKTGSL- 2943
LN V ++ L +A + + + I + A + A ++ +T +
Sbjct: 1918 LNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVM 1977
Query: 2944 -EEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
E+M + ++ V A LE+ L + K+ E L Q+E L+ ++
Sbjct: 1978 TEDMPLEISYVPSTYLTEITHVSQAL--LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 2035
Query: 3003 -------QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--EVKQRVNSGCVMME 3053
++D + + ++ A + ++ Q ++Q +F +V + +
Sbjct: 2036 SLQQSSGRIDIIHSKKTAALQSA---TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2092
Query: 3054 NKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ--IEDVRLFLNKIHVLK 3111
+E +FH ++ +F+Q ++ I + + + + +++++ + + +
Sbjct: 2093 RSVEKWRRFHYDIK-IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVV 2151
Query: 3112 LDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQ----CGKLTERGKARQEQLELTLGR 3167
+ A+ E ++++ D L+ +L +LN + C +L++R K +EQ +
Sbjct: 2152 RTLNATGEE---IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI---- 2204
Query: 3168 VEDFYRKLKGLNDATTAAEEAEALQWVV---GTEVEIINQQLADFKMFQKEQVDPLQMK- 3223
+ +F R L N+ EEA+ + + G E ++ ++L K+ +E PL+
Sbjct: 2205 LSEFQRDL---NEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL--PLRQGI 2258
Query: 3224 LQQVNGLGQGLIQSAGKDCDVQG-LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF 3282
L+Q+N G ++ SA + Q LE+ +++ N +W +++ + ++ +++ + G+
Sbjct: 2259 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2318
Query: 3283 QDALEPL-------LSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVD 3335
+ LE L L WL+ + P+ E +QE ++ + ++ V+
Sbjct: 2319 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF---DVQETEIA---VQAKQPDVE 2372
Query: 3336 MLQAEGGRIAQSAELADREKITGQLESLESRW---TELLSKAAARQKQLEDIL------- 3385
+ ++G + + E + + +LE L S W LL + A+Q L L
Sbjct: 2373 EILSKGQHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 2430
Query: 3386 ----------VLAKQ---------------------FHETAEPISDFLSVTEKKLANSEP 3414
V+ K+ F+ ++D+LS+ ++ + +
Sbjct: 2431 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2490
Query: 3415 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQ 3473
+ I + II+ KA +D+E + + + Q+L + TS E + +++++I+ +Q
Sbjct: 2491 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2550
Query: 3474 ARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHR 3533
++ E+Q+ + L++ L ++ + E + E L + KL S + D + +
Sbjct: 2551 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2610
Query: 3534 QHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSS 3593
+ + L +++ + NVD A LL+ + ++ + + I + I S
Sbjct: 2611 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2670
Query: 3594 KALRTLEQARQLATKFQSTYEELTGWLREVE------EELATSGGQSPTGEQIPQFQQRQ 3647
+ LE+ +L +F E+ WL E E ++ + + + ++
Sbjct: 2671 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 2730
Query: 3648 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLV------SDANEQYKLVSDTI 3701
++L+ E+ H V ++E S+ +L R+ EG D V + N ++ +
Sbjct: 2731 QDLQGEIEAHTDVYHNLDENSQKIL-----RSLEGSDDAVLLQRRLDNMNFKWSELRKKS 2785
Query: 3702 GQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF-- 3759
++A+ + ++ + L W+ +L PI + Q V +AF
Sbjct: 2786 LNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKR 2845
Query: 3760 -----------SIDIIR------HKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQ 3801
+++ +R + +++L+ E+ + T +L+++ E +
Sbjct: 2846 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNT 2905
Query: 3802 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQ 3860
++E ++L +++ +++ + + E +EL + + + P + + L+
Sbjct: 2906 EWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQD 2965
Query: 3861 QQEEMRQLRESIAEHKPHIDKLLKIGPQLK----ELNPEEGEMVEEKYQKAENMYAQIKE 3916
E+++ LR IA K ++ + + QL +L+P +E+ + + + +++
Sbjct: 2966 HLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVED 3025
Query: 3917 EVRQ 3920
VRQ
Sbjct: 3026 RVRQ 3029
Score = 184 bits (467), Expect = 2e-45
Identities = 361/1991 (18%), Positives = 773/1991 (38%), Gaps = 283/1991 (14%)
Query: 3270 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDD 3329
+ L E+ ++ ++Q ALE +LSWL E+ + Q S + +VVK Q + L
Sbjct: 324 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 383
Query: 3330 RKATVDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTELLSKAAARQKQLEDILVL 3387
+ V + G ++ + +L++ E+ + Q+ L SRW L + A+ +KQ VL
Sbjct: 384 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL--RVASMEKQSNLHRVL 441
Query: 3388 AKQFHETAEPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3445
++ + ++D+L+ TE++ EP+G +++Q+ +HK L+ED+E V+
Sbjct: 442 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 501
Query: 3446 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 3505
+ + + L E++ L R++ I + LL L + E++
Sbjct: 502 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQC 561
Query: 3506 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA-LNEEIVNRKKNVDQAIKNGQALLK 3564
WL+E ED ++ + FK LA L ++ +K+++ + Q LL
Sbjct: 562 LFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLS 621
Query: 3565 QTTGEEVLLIQEKL--------DGIKTRYADITVTSSKALRTLEQARQLATKFQS----- 3611
+ V E D + + T S+A+ T + + T ++
Sbjct: 622 TLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 681
Query: 3612 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVME-HRLVLDTVNEVSRA 3670
T E++ ++ +EEL Q QI + +K L ++ E H + T +E
Sbjct: 682 TREQIL--VKHAQEELPPPPPQKK--RQITVDSEIRKRLDVDITELHSWI--TRSEAVLQ 735
Query: 3671 LLELVPWRAREGLDKLVSDAN-------EQYKLVSDT-------IGQRVDE---IDAAIQ 3713
E +R L N E+++ + D + Q V+E D+ Q
Sbjct: 736 SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQ 795
Query: 3714 RSQQYE-------QAADAELAWVAETKRKLMALGPIR-LEQDQTTAQ--LQVQK------ 3757
S+Q Q L W+ + ++ LEQ TTA+ L++Q
Sbjct: 796 ASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP 855
Query: 3758 -AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES-LIQQYEAISLLN----- 3810
A + KD ++ L + +I + Q L+EK + + + ++ N
Sbjct: 856 TAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQV 913
Query: 3811 -SERYARLERAQVLVN-----QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 3864
S+ AR + Q + + ++ ET + W++++ ++ D+E + Q+ E
Sbjct: 914 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 973
Query: 3865 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALA 3924
++ L+ S+ E + L + +KE++ + + KYQ EE+ R
Sbjct: 974 LQALQSSLQEQQ---SGLYYLSTTVKEMSKKAPSEISRKYQSEF-------EEIEGRWKK 1023
Query: 3925 LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK--------------IR 3970
L S+Q+ E K+E + L + + ++ AEVD ++
Sbjct: 1024 L------SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 1077
Query: 3971 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4030
+ + + +++ +QPS ++ G+++ A+ + A++ ++ +L ++ W+ +
Sbjct: 1078 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKI---KNEAEPEFASR-LETELKELNTQWDHM 1133
Query: 4031 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4090
+ R+ LE D++ + + ++ + + P +++ VE +
Sbjct: 1134 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1193
Query: 4091 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4150
KEE +++ + +I + ++K ++ + ++ L + + L
Sbjct: 1194 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1253
Query: 4151 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MPPVGTDLNTVKDQL-NEMKEFKVEVY 4206
E+ + L+ WL+ KL T +P +++ V D L N M+ +
Sbjct: 1254 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1313
Query: 4207 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4266
Q +I + L G + ++I E L W L E+ RQ LE ++ +
Sbjct: 1314 QIRILAQTLTDGGVM----------DELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1363
Query: 4267 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326
+ + +L + LT ++ L A D + E K +++D+ +H+ ++E +
Sbjct: 1364 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMK 1420
Query: 4327 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4386
K + + A + S+++ + + V K Q+ F +++
Sbjct: 1421 K------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQKPANFEQRLQES 1466
Query: 4387 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4446
+ L ++ L A + E + QL+ + LY L + ++ GR ++ +
Sbjct: 1467 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR-QIVQKK 1525
Query: 4447 DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQS 4506
+ + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + + + WL +
Sbjct: 1526 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1585
Query: 4507 LNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 4566
L S + + + S++ K E+ + + + + G LK + K++ L+++
Sbjct: 1586 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-LVEDK 1644
Query: 4567 LVSVQSRWEKVVQRS----------------------------IERGRSLDDA-RKRAKQ 4597
L + S W V R+ I+ LD++ +K+ +Q
Sbjct: 1645 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1704
Query: 4598 FHEAWKKLIDWLEDAESHLDSELE-----ISNDPD------------------------- 4627
+ K+L L D +DS + ++N D
Sbjct: 1705 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1764
Query: 4628 --KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 4685
K + L + ++F + + I+ G LKE+ + ++ + + E+ + D
Sbjct: 1765 TGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGD 1824
Query: 4686 TVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLYKVEPQLAEDQP 4731
+ + + + + E + L S + AL+ W Y+ + Q +
Sbjct: 1825 NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-YQYKRQADDLLK 1883
Query: 4732 VHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 4785
D++ + + D K+ +EL K+ + ++R L E+ V+
Sbjct: 1884 CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--AMAVEPTQ 1941
Query: 4786 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTE 4845
+LS RW + + ++ RL A Q R+ M++ E + L + T
Sbjct: 1942 IQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 1998
Query: 4846 ALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 4893
Q+L++ + E + K EE ++ ++ + + H ++
Sbjct: 1999 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2058
Query: 4894 ITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEELLAWIQWAETT 4942
+ R + +E L+ W K Q R + ++ + ++ W+ AE
Sbjct: 2059 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2118
Query: 4943 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKS 5002
L + IP+N + K ++ +++E+ V +T
Sbjct: 2119 LRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN--------------- 2155
Query: 5003 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5062
+ G + + Q + IL + ++ L+ RWQ+V +R+++L + + L E
Sbjct: 2156 -ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEF 2208
Query: 5063 KEFANFDFDVW 5073
+ N +F +W
Sbjct: 2209 QRDLN-EFVLW 2218
Score = 91.3 bits (225), Expect = 2e-17
Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 31/555 (5%)
Query: 4585 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 4644
G SL ++ ++ A ++++ WL AE L ++ EISND + +K Q H+ + L
Sbjct: 323 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 382
Query: 4645 GKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 4703
Q ++ G L L ED + ++ + + +W+ + S+E+Q L L+
Sbjct: 383 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 442
Query: 4704 FSGQFMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 4761
L+ L DWL K E + E++P+ DL+ + + HKV Q++L + V
Sbjct: 443 DLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 500
Query: 4762 VLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 4820
L + E+S D T ++ QL+ L RW +C+ + + L+ L + + +
Sbjct: 501 SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 560
Query: 4821 HMLLEWLSEAEQTLR--FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVI 4878
+ WLSE E + D E L SL +E+K+ + ++ + +
Sbjct: 561 CLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL-QKLAVLKADLEKKKQSMGKLYSLKQDL 619
Query: 4879 LAVCHPDCIT-TIKHWITIIRARFEEVLTWAKQHQQRLETAL--SELVANAELLEELLAW 4935
L+ +T + W+ ++ ++ ++ ++ A+ ++ + E +
Sbjct: 620 LSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 679
Query: 4936 IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIE 4992
+ E L++ QE +P + K Q ++ RK+ DVD +T+ + R
Sbjct: 680 VTTREQILVKHAQEELPPPPPQKK-----RQITVDSEIRKRLDVD-ITELHSWITRSEAV 733
Query: 4993 PTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKL 5052
F + G L + + + + +A+ R Q ++R Q + + +
Sbjct: 734 LQSPEFAIFRKEGNFSDLKE----KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 789
Query: 5053 NDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5112
D++ + E +F + + W+ + ++ ++ F+ ++ + + T + ++
Sbjct: 790 ADSIKQASEQLNSRWIEFCQLLSERLNWLEY-QNNIIAFYNQLQQLEQMTTTAENWL--- 845
Query: 5113 LASKFPTTKLEMTAV 5127
PTT E TA+
Sbjct: 846 --KIQPTTPSEPTAI 858
>gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]
Length = 3562
Score = 351 bits (900), Expect = 1e-95
Identities = 526/2787 (18%), Positives = 1138/2787 (40%), Gaps = 333/2787 (11%)
Query: 2222 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2281
G+ +DL HQ RV N+ + ++L T K E + + QEQ++ + E +
Sbjct: 261 GYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQS 320
Query: 2282 SIPPTETSMSAKELEKQIEHLKSLLDDWASKG---TLVEEINCKGTSLENL--------I 2330
++ + ++L++ L+DW +K T E G LE+L +
Sbjct: 321 NLHRVLMDLQNQKLKE--------LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 372
Query: 2331 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2390
++ Q + S+ V V +G H L E + D ++ + +R
Sbjct: 373 LQEDLEQEQVRVNSLTHMV-VVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRW 428
Query: 2391 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN--KAFLA 2448
LQ IL + + + +E WL KE+ + + + E + + + KA L
Sbjct: 429 VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 488
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENW-------------------KKIQEELNS 2489
+ +Q+ K+ +K+ L L +Q+ E W +I + + +
Sbjct: 489 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 548
Query: 2490 RWERATEVTVA---------------------------RQRQLEESASHLACFQAAESQL 2522
T+ TV ++RQ+ + ++L
Sbjct: 549 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 608
Query: 2523 RPWLMEKE-LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 2581
W+ E ++ + + K++V + +E + ++ + + +AQ ++
Sbjct: 609 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 668
Query: 2582 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 2641
+ ++ +++ + +N +W+E L+ R + ++ Y +L Q L +
Sbjct: 669 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQL-QQLEQMTTTAE 727
Query: 2642 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC-DELSVLIGEQYLKDE 2700
L +Q ++P A+K QL+ +C DE++ L G Q +
Sbjct: 728 NWLKIQPTTPSEPTAIKSQLK---------------------ICKDEVNRLSGLQPQIER 766
Query: 2701 LKKRLETVALPLQGLEDLAADR-----INRLQAALASTQ----------------QFQQM 2739
LK ++++AL +G + D N + + Q ++Q+
Sbjct: 767 LK--IQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQET 824
Query: 2740 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN-QHSGSYEVIVAEGESL 2798
+RTW+ +++ + E ++ +L E + Q SL Q SG Y + E
Sbjct: 825 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE-- 882
Query: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858
+ P E R Q++ E++ W++LS + + +L++ M K +K Q H++ L W+
Sbjct: 883 MSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMA 942
Query: 2859 DCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-ED 2916
+ + E L D L+ L + + ++++++ + L +N + N +E +
Sbjct: 943 EVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS 1002
Query: 2917 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFD 2975
+ E +N D + +++ A+ +L+ ++ Q+ + + + A+ + LE
Sbjct: 1003 RLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDF 1062
Query: 2976 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3035
+ K +E+++ +E Q E +V L ++ AP + + L + E
Sbjct: 1063 EYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA-LKKELETLT 1121
Query: 3036 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3095
+ + R+N C +E E +H E+ S L + L+ + + T+++
Sbjct: 1122 TNYQWLCTRLNGKCKTLE---EVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPG 1174
Query: 3096 QIEDVRLFLNKIHVLKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTE 3152
E++ L+ + L E + + R + L + G +D L + ELE N + +L E
Sbjct: 1175 GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL-INEELETFNSRWRELHE 1233
Query: 3153 RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMF 3212
RQ+ LE ++ +A+E E ++ + I++QLA +
Sbjct: 1234 EAVRRQKLLEQSI-----------------QSAQETEKSLHLIQESLTFIDKQLA---AY 1273
Query: 3213 QKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA-- 3270
++VD QM + IQS D+ E +EE+ + K+ AQR+
Sbjct: 1274 IADKVDAAQMPQEAQK------IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQ 1320
Query: 3271 ------QLQEALLHC------GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3318
+LQ+ + F+ L+ L + + + + S E +VV++Q+
Sbjct: 1321 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1380
Query: 3319 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3378
L + L + K+ V+M+ G +I Q + + +++ ++ +L+ + EL +K R+
Sbjct: 1381 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1440
Query: 3379 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3438
+QLE L L+++ + ++++L+ T+ +L V + + ++ KA +++IE
Sbjct: 1441 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1500
Query: 3439 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 3498
+ ++G++L ++ E ++ +K+ L + + + R LL + +
Sbjct: 1501 QKVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME 1559
Query: 3499 LFGEDEVEVLNWLAEVEDKLSSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 3556
F ++ + W+ + + L K K+DVL R L E+ + + VD
Sbjct: 1560 TFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTR 1612
Query: 3557 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYE 3614
L+ L++ ++ + R+A I+ + + KA L++ Q + Q E
Sbjct: 1613 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1672
Query: 3615 ELTGWLRE---VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVN 3665
L +++ ++EE + + QR L++ + + R + +
Sbjct: 1673 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1732
Query: 3666 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQ 3720
AL +L R ++ L+ +S QYK +D + + +D+I+ + R ++ +
Sbjct: 1733 TKHNALKDLRSQRRKKALE--ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK 1790
Query: 3721 AADAELAWVAETKRKLMALGPIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHR 3777
D EL ++K L +R + + + A + V+ I + + ++ F+
Sbjct: 1791 EIDREL------QKKKEELNAVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ- 1842
Query: 3778 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 3837
F Q ++E+T ++ + + + + + + +S
Sbjct: 1843 ---FRRLNFAQIHTVREETMMVMTEDMPLEI------------SYVPSTYLTEITHVSQA 1887
Query: 3838 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEE 3896
+ E L+ A D E L +Q+E ++ +++S+ + ID + K L+ P E
Sbjct: 1888 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 1947
Query: 3897 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 3956
++E + + + ++ + + R D +V + + FH I+ + L L
Sbjct: 1948 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFL 2004
Query: 3957 RMPPLIPA--EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4014
R IP E K + + + + + + Q L GEE+I +S D +
Sbjct: 2005 RKTQ-IPENWEHAKYKWYLKELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI--- 2057
Query: 4015 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4074
+Q+KL + W+++ + +R+ + + + +F D+ + +++ +I
Sbjct: 2058 -LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE 2116
Query: 4075 PGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEM 4132
PG + + K+++E + + EE L+ + G ++ + E+ ++ + +
Sbjct: 2117 PGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2175
Query: 4133 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4192
N W +++ E+ ++E ++ Q + L+ + + L++ ++ L P+ L
Sbjct: 2176 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYN 2232
Query: 4193 DQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKK--ATDETDRDI---------IRE 4237
E ++E ++ V +Q ++E++ +G+ + K+ AT R + +
Sbjct: 2233 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNR 2292
Query: 4238 PLTELKHLWENLG-----------------------EKIAHRQHKLEGALL----ALGQF 4270
L EL+ +L ++ A + ++ +L+ AL F
Sbjct: 2293 LLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADF 2352
Query: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4330
A EL WL+ ++++ +QR + GD + I + K D+ + +E + A
Sbjct: 2353 NRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 2412
Query: 4331 ELLESSAGDDASS-LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4389
L ++ +A + + R+E + W+ V + + R QQL L+ + + E+
Sbjct: 2413 NLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQV 2472
Query: 4390 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4449
L + ++L + K + ++++ +L L+ + +T + + L LL +
Sbjct: 2473 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSAD 2531
Query: 4450 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 4509
K + W + ++ ER++ LEE L +F L++F+ WLT AE + N+
Sbjct: 2532 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV 2591
Query: 4510 ---ASPPSLILNT---VLSQIEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVL 4562
A+ +L V +++ + E+ AH D LD+ + L+ L D VL
Sbjct: 2592 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 2651
Query: 4563 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 4622
++ L ++ +W ++ ++S+ L+ + + K+ H + ++L+ WL+ + L + I
Sbjct: 2652 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPI 2711
Query: 4623 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--------------KEKTLLPE 4668
D ++ Q H+ F++ L K+PV +T+ T R + + L PE
Sbjct: 2712 GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE 2771
Query: 4669 D-SQKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 4723
+ +Q + L EV +W+ + S + Q K++E L + +A L L + E
Sbjct: 2772 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2831
Query: 4724 PQLAEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 4781
QPV GDL D + + ++ K + E+ V + R+L + +
Sbjct: 2832 VIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 2890
Query: 4782 KGQLQELSTRWDTVCKLSVSKQSRLEQ 4808
L++L+TRW L V+ + R+ Q
Sbjct: 2891 LSTLEDLNTRWKL---LQVAVEDRVRQ 2914
Score = 325 bits (833), Expect = 8e-88
Identities = 518/2775 (18%), Positives = 1115/2775 (40%), Gaps = 293/2775 (10%)
Query: 2270 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL---VEEINCKGTSL 2326
++F L E+E ++ +T+ LE+ + L S D ++G + VE + + +
Sbjct: 205 KSFGSSLMESEVNLDRYQTA-----LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 259
Query: 2327 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2386
E +M++TA QG+ G+IL +G+ G + + TE+Q M+ +N ++E L
Sbjct: 260 EGYMMDLTA--HQGRVGNILQLGSKLIGT--GKLSEDEETEVQEQMNLLNSRWECLRVAS 315
Query: 2387 HERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2446
E+Q +L +L M+ +++ + WL EE + M+ E +K Q + +K
Sbjct: 316 MEKQSNLHRVL--MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVL 373
Query: 2447 LAELEQNSPKIQK------VKEALAGLLVTYPNSQE----AENWKKIQEELNSRWERATE 2496
+LEQ ++ V + +G T ++ + W I RW +
Sbjct: 374 QEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 433
Query: 2497 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQF 2555
+ + QR EE C +A WL EKE + + D N + + Q++
Sbjct: 434 ILLKWQRLTEEQ-----CLFSA------WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV 482
Query: 2556 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 2615
+ + E ++Q +L Q +L+ + S+ T + + L + + W L KL ++Q
Sbjct: 483 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSV-TQKTEAWLDNFARCWDNLVQKLEKSTAQ 541
Query: 2616 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSV-----QSAISTQPEAVKQQLEETSEIRS- 2669
I QA+ +TQ + E V V R + Q + P K+Q+ SEIR
Sbjct: 542 ISQAVT-TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 600
Query: 2670 ---DLEQLDHEVKEAQTLCD--ELSVLIGEQYLKD-------------ELKKRLETVALP 2711
D+ +L + ++ + E ++ E D E ++L+ +
Sbjct: 601 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 660
Query: 2712 LQGL------EDLAADRINRLQAALASTQ-QFQQMFDELRTWLDDK--------QSQQAK 2756
Q L E + AD I + L S +F Q+ E WL+ + Q QQ +
Sbjct: 661 AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 720
Query: 2757 NCPISA----KLE--------RLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 2804
+A K++ ++SQL+ ++ +N+ SG I +
Sbjct: 721 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---EVNRLSGLQPQIERLKIQSIALKEK 777
Query: 2805 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA--QKYQWHVEDLVPWIEDCKA 2862
G+ L V NH++++ R+ L+ +YQ + + W++ +
Sbjct: 778 GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 837
Query: 2863 KMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-EDGIR 2919
K+S +L VT D +E L +A+ + +++++S L L++ + + ++ +
Sbjct: 838 KLSIPQLSVT-DYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 896
Query: 2920 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL-EIFDALG 2978
E I ++ +L LEE +LR+ Q + ++K + L E + ALG
Sbjct: 897 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 956
Query: 2979 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3038
K L++ R +Q ++P ++ + Q + +A + AS+L + + ++
Sbjct: 957 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQW 1015
Query: 3039 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3098
+ Q+V + ++ LE + EM + ++E + D LQ +E
Sbjct: 1016 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1075
Query: 3099 DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ 3158
+++ + + ++ ++ + + LK+ELE L L R +
Sbjct: 1076 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1135
Query: 3159 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3218
+ LE + L+ N E + E I++ L + + D
Sbjct: 1136 KTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSED 1195
Query: 3219 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3278
Q+ L Q L D + + ++E N+RW L+++ +R L++++
Sbjct: 1196 ----NPNQIRILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI-- 1246
Query: 3279 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQI-QEQKLLQRLLDDRKATVDML 3337
+ E L + ++ I Q KV AQ+ QE + +Q L + +++ +
Sbjct: 1247 --QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM 1304
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA-- 3395
+ Q E A R +LS+ QK+L+D+ + + F + A
Sbjct: 1305 KKHN----QGKEAAQR----------------VLSQIDVAQKKLQDVSMKFRLFQKPANF 1344
Query: 3396 ----EPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3451
+ L + L E + +Q Q+ L + + ++V +K G+
Sbjct: 1345 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1404
Query: 3452 SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL 3511
+ L E++ +L+ Y+E+ + + L++ L +R ++ + WL
Sbjct: 1405 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1464
Query: 3512 AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 3571
A + +L+ + L + A A +EI +K ++ + G+AL K G++
Sbjct: 1465 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKE 1523
Query: 3572 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 3631
L+++KL + + + +T + + L L + ++ F + +T W+ + + L S
Sbjct: 1524 TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE 1583
Query: 3632 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 3691
+ P Q + K LK E+ + R +D+ + + L+ R+ ++ +S+ N
Sbjct: 1584 KKKPQ-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 1638
Query: 3692 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA 3751
++ +S I + + ++ +Q+ ++++ + E + G E+D
Sbjct: 1639 HRFAAISHRI--KTGKASIPLKELEQF----NSDIQKLLEPLEAEIQQGVNLKEEDFNKD 1692
Query: 3752 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 3811
+ + ++++ D++ + + E ++ ++ K + L ++ A+ L S
Sbjct: 1693 MNEDNEGTVKELLQRGDNLQQRITD---------ERKREEIKIKQQLLQTKHNALKDLRS 1743
Query: 3812 ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES 3871
+R + Q+ ++L +++ +A LP P D ++++ E+++ +E
Sbjct: 1744 QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEE 1802
Query: 3872 IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQ-----------IKEE--- 3917
+ + + L + G + + P + ++ +++++ E+ +AQ ++EE
Sbjct: 1803 LNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKRWREIESKFAQFRRLNFAQIHTVREETMM 1860
Query: 3918 VRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNK 3977
V + L+ + ST +TE + +LE + L++ P L + + + + K
Sbjct: 1861 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA----PDLCAKDFEDLFKQEESLK 1916
Query: 3978 SATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEER 4037
+ L++ + + + + + ++ ++Q+ L Q+ F WE + ++R
Sbjct: 1917 NIKDSLQQSSGRIDIIHSKKTAALQSATPVER----VKLQEALSQLDFQWEKVNKMYKDR 1972
Query: 4038 EIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET---IKE 4094
+ +F +E +F YD+ + + + + + P + E A+ +KE
Sbjct: 1973 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKE 2024
Query: 4095 ETDGLHEELEFIRIL---GADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE 4151
DG+ + +R L G ++I +T+ +++ + +N W+ + K +R ++LE
Sbjct: 2025 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 2084
Query: 4152 DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE 4211
+ ++Q L WL+ + ++P +K++L ++K E+ +Q
Sbjct: 2085 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 2143
Query: 4212 MEKLNHQGELMLKKAT-DETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270
+++LN G +L A ++D + L + W + + +Q ++E + LGQ
Sbjct: 2144 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2203
Query: 4271 QHALEEL-------MSWLTHTEELLDA--QRPISGDPKVIEVELAKHHVLKNDVLAHQAT 4321
+ LE+L + WL+ L+ Q G V E E+A V A Q
Sbjct: 2204 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPD 2255
Query: 4322 VETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV---LQKTEEREQQLQSTLQQAQG 4378
VE + G L + ++ +LE ++ W++V LQ+ ++ L L
Sbjct: 2256 VEEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 2313
Query: 4379 FHSEI----------EDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4428
++ ++ + M S L P A +L + L Q+ +
Sbjct: 2314 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2373
Query: 4429 -------ETYNQLLDKGRLML-------------------LSRDDSGSGSKT--EQSVAL 4460
E N+++ K + + L S ++T +
Sbjct: 2374 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 2433
Query: 4461 LEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTV 4520
++ +W V ++ R+ +L E L +T++ + +E L A L ++ +
Sbjct: 2434 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 2493
Query: 4521 LSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQR 4580
+I E K A ++ + + + +L D + + ++ + W + +R
Sbjct: 2494 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 2553
Query: 4581 SIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD------SELEISNDPDKIKLQLS 4634
ER +L++ + +QF +K + WL +AE+ + + + D +K +
Sbjct: 2554 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2613
Query: 4635 KHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
+ ++ Q + VY + + +D+ L L + KW + KS+
Sbjct: 2614 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2673
Query: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG 4754
+ LE + + +LQ L+ WL + +L+ P+ GD V D H+ F++EL
Sbjct: 2674 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 2733
Query: 4755 KRTGTV-------------------QVLKRSGRELI--ENSRDDTTWVKGQLQELSTRWD 4793
+ + + L + REL E +++ T ++ Q +E++T W+
Sbjct: 2734 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 2793
Query: 4794 TVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDT 4853
+ S Q ++++ L++ + ++ L L +AE + D LID+
Sbjct: 2794 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDS 2847
Query: 4854 HKEFMKKVEEKRVDV 4868
++ ++KV+ R ++
Sbjct: 2848 LQDHLEKVKALRGEI 2862
Score = 322 bits (826), Expect = 5e-87
Identities = 541/2849 (18%), Positives = 1142/2849 (40%), Gaps = 300/2849 (10%)
Query: 2332 EITAPDSQG--KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEK-LGGVLHE 2388
+IT +QG +T S P S + Y T D T + +K G L E
Sbjct: 154 QITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLME 213
Query: 2389 RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2448
+ +L +EEV L WL S E+ L++ +S+ E VK Q +++ ++
Sbjct: 214 SEVNLDRYQTALEEV-------LSWLLSAEDTLQAQGEISNDV--EVVKDQFHTHEGYMM 264
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEE---LNSRWERATEVTVARQRQL 2505
+L + ++ + + + L+ T S++ E ++QE+ LNSRWE ++ +Q L
Sbjct: 265 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWECLRVASMEKQSNL 322
Query: 2506 EESASHLACFQAAESQLRPWLMEKELMMGVLG--PLSIDPNMLNAQKQQVQFMLKEFEAR 2563
L + E L WL + E + PL D L Q QQ + + ++ E
Sbjct: 323 HRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQE 380
Query: 2564 RQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKS 2623
+ + L + GD + T+ ++++L+ + +W + R
Sbjct: 381 QVRVNSLTHMVVVVDESSGDHA--TAALEEQLKVLGDRWANICRWTEDR----------- 427
Query: 2624 TQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 2683
LLQD+ K + + + + SA ++ E ++ T K+
Sbjct: 428 ---WVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTG------------FKDQNE 472
Query: 2684 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDEL 2743
+ L L LK +L+K+ +++ +DL + N+ + TQ+ + D
Sbjct: 473 MLSSLQKLA---VLKADLEKKKQSMGKLYSLKQDLLSTLKNK-----SVTQKTEAWLDNF 524
Query: 2744 -RTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 2802
R W + Q + IS + Q L + + ++ + +++V + L
Sbjct: 525 ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVME-TVTTVTTREQILVKHAQEEL-PP 582
Query: 2803 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKA 2862
PP ++KR + T D + R ++ + +L WI +A
Sbjct: 583 PPPQKKRQI-----------------TVDSEIR--------KRLDVDITELHSWITRSEA 617
Query: 2863 KMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL--LEILNSAADILIN---SSEADEDG 2917
+ + + S L+ K E EK L+ + +A L+ + + D
Sbjct: 618 VLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADS 677
Query: 2918 IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDAL 2977
I+ +N + L + LE + F + +E+ A++ L+I
Sbjct: 678 IKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQLEQMTTTAENWLKIQPTT 736
Query: 2978 GSQACSNKNLEKLRAQQEV--LQALEPQVDYLRNFTQGLVE--DAPDGSDASQLLHQAEV 3033
S+ + K+ K+ + EV L L+PQ++ L+ + L E P DA +
Sbjct: 737 PSEPTAIKSQLKI-CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHF 795
Query: 3034 AQQEFLEVKQRVNSGCVMMENKLEGIGQF--HCRVREMFSQLADLDDELDGMGAIGR--- 3088
+Q F +V+ R E +L+ I R +E S + + + +I +
Sbjct: 796 -KQVFSDVQAR--------EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSV 846
Query: 3089 -DTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQC 3147
D + ++ ++ +++ + + + + + M ++ + + E E + +
Sbjct: 847 TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRW 906
Query: 3148 GKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3207
KL+ + ++LE + ++ ++ L + +W + EI+ +QL
Sbjct: 907 KKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLK 966
Query: 3208 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3267
++ + + +Q L VN GQ + A + LE +++E+N +W+ + ++V
Sbjct: 967 QCRLLVSD-IQTIQPSLNSVNEGGQKIKNEAEPEF-ASRLETELKELNTQWDHMCQQVYA 1024
Query: 3268 RIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV---VKAQIQEQKLLQ 3324
R L+ L Q L + W+ EE + EYK ++ ++E K +
Sbjct: 1025 RKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLER---DFEYKTPDELQKAVEEMKRAK 1081
Query: 3325 RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDI 3384
++A V +L + A +E + +LE+L + + L ++ + K LE++
Sbjct: 1082 EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV 1141
Query: 3385 LVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3444
+ E + +L+ E KL +E + +I + + +LE + + + +
Sbjct: 1142 WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL---DSLENLMRHSEDNPN 1198
Query: 3445 QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDE 3504
Q + Q+L+ +++E++++ +R+ E+ + R+ LL+Q++ +A+ E
Sbjct: 1199 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQET-EKS 1255
Query: 3505 VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL-L 3563
+ ++ DK + ++ D Q A + ++ + + ++++ K+ Q
Sbjct: 1256 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI--QSDLTSHEISLEEMKKHNQGKEA 1313
Query: 3564 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 3623
Q ++ + Q+KL + ++ + Q F+ +E L EV
Sbjct: 1314 AQRVLSQIDVAQKKLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEV 1358
Query: 3624 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 3683
+ L +S E + L K + E + ++ V + R +++ + L
Sbjct: 1359 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1418
Query: 3684 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 3743
D+ V+ Y + + +R +++ ++ S++ + + W+A T +L +
Sbjct: 1419 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1478
Query: 3744 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 3803
+++ KA +I + K + + +E+ GE KTVL +K E+L++
Sbjct: 1479 GMPSNLDSEVAWGKATQKEIEKQKVHLKSI----TEV----GEALKTVLGKK-ETLVE-- 1527
Query: 3804 EAISLLNSERYARLERAQVLVNQFWETYEELSPW---IEETRALIAQLPSPAIDHEQLRQ 3860
+ +SLLNS A RA+ +N E + + + ++ I Q + + E+ +
Sbjct: 1528 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1587
Query: 3861 QQEE--MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGE----MVEEKYQKAENMYAQI 3914
QQ+E +++L+ + + +P +D Q L G+ +VE + + + +A I
Sbjct: 1588 QQKEDVLKRLKAELNDIRPKVDSTRD---QAANLMANRGDHCRKLVEPQISELNHRFAAI 1644
Query: 3915 KEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE-NLSSRLRMPPLIPAEVDKIRECI 3973
++ +A ++ +F+ I+ +LE LE + + + E D ++
Sbjct: 1645 SHRIKT-----GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK-----EEDFNKDMN 1694
Query: 3974 SDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKAR 4033
DN+ EL +RG+ L Q + +EI+ K + +K
Sbjct: 1695 EDNEGTVKEL----------LQRGDNL---QQRITDERKREEIKIKQQLLQTKHNALKDL 1741
Query: 4034 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIK 4093
+R K L++ ++ LL + D + + L P D IK+ + K
Sbjct: 1742 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKK 1800
Query: 4094 EETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN-----KTWKERLE 4148
EE + + + E + GA + + + + + I+ + LN +E +
Sbjct: 1801 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1860
Query: 4149 KLEDAMQAAVQYQDTL---------QAMFDWLDNTVIKLCTMPPV-GTDLNTVKDQLNEM 4198
+ + M + Y + QA+ + V +L P + D + Q +
Sbjct: 1861 VMTEDMPLEISYVPSTYLTEITHVSQALLE-----VEQLLNAPDLCAKDFEDLFKQEESL 1915
Query: 4199 KEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQH 4258
K K + Q ++ ++ + L+ AT +R ++E L++L WE + + RQ
Sbjct: 1916 KNIKDSLQQSSGRIDIIHSKKTAALQSATP-VERVKLQEALSQLDFQWEKVNKMYKDRQG 1974
Query: 4259 KLEGALLALGQFQHALEELMSWLTHTEELL-DAQRPISGDPKVIEVELAKHHVLKNDVLA 4317
+ + ++ +F + ++ WLT E+ L Q P + + + L + L++ +
Sbjct: 1975 RFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQ 2031
Query: 4318 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4377
Q V T+N G E+++ S+ DAS L+ +L ++N W+ V ++ +R+++L+
Sbjct: 2032 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2091
Query: 4378 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4437
F ++ +F+L L ++ +++ G + +E+L+ L +L ++ QL +
Sbjct: 2092 EFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNET 2150
Query: 4438 GRLMLLSRDDSGSGS-KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4496
G +L+S S K E + +W VS + E++ ++E + + + L++
Sbjct: 2151 GGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2210
Query: 4497 -------INWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 4549
+ WL+ L I + P+ ++E ++ V A + + E+ G
Sbjct: 2211 EEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQ 2264
Query: 4550 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQ------------------------------ 4579
L +K +K L + S W+ V +
Sbjct: 2265 HL--YKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2322
Query: 4580 -----------RSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 4628
+E SL F+ AW +L DWL + + S+ + D +
Sbjct: 2323 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2382
Query: 4629 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 4688
I + K K + L ++P + I + LK KT E + + + ++++WD V
Sbjct: 2383 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2442
Query: 4689 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 4748
R+ +L E L S Q+++A + L + +L + +D + + K
Sbjct: 2443 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2502
Query: 4749 FQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLE 4807
K+L + V V +L+ + S DDT V + ++ W ++ K +++ LE
Sbjct: 2503 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2562
Query: 4808 QALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTH--KEFMKKVEEKR 4865
+ + + F + L WL+EAE T L D T + L D+ KE MK+ ++ +
Sbjct: 2563 ETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2619
Query: 4866 VDVNSAVAM--------GEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 4917
++ + + +++ ++ D ++ + + ++ E+ + + LE
Sbjct: 2620 GEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA 2679
Query: 4918 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 4977
+ + L+ELL W+Q + L + Q PI + V+ H+ F E+ K+P
Sbjct: 2680 SSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEP 2737
Query: 4978 DVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP--TPPPMPILSQSEAKNPRINQLS 5035
+ +E E+ G K +P PP + + + +++
Sbjct: 2738 VI--------MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVN 2789
Query: 5036 ARWQQVWLLALERQRKLNDALDRLEELKE 5064
W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 2790 TEWEKLNLHSADWQRKIDETLERLQELQE 2818
Score = 296 bits (757), Expect = 5e-79
Identities = 510/2885 (17%), Positives = 1162/2885 (40%), Gaps = 305/2885 (10%)
Query: 1936 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 1995
++Q + + + +W+ + E ++ +++D V+++Q T + +L HQ V +
Sbjct: 220 RYQTALEEVLSWLLSAEDTLQA--QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 277
Query: 1996 KVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLE 2055
++ ++ + VQE + + S ++ L + E+ S L + + Q+ + L+
Sbjct: 278 QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN--QKLK 335
Query: 2056 SLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFM 2113
L + + E+ + L + ++ + + L++D+ +++ + + MV
Sbjct: 336 ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVD 395
Query: 2114 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQF 2169
E++ A L+ +L + R+ +C +++ L+ +L + + S L +
Sbjct: 396 ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 455
Query: 2170 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2229
+ +++ +G + ++ Q++ L ++E +++++ L L +L S + Q
Sbjct: 456 EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 515
Query: 2230 HQDR------------VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL- 2276
+ VQ L K ++ + V + S Q + E V T ++ L
Sbjct: 516 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQP--SLTQTTVMETVTTVTTREQILV 573
Query: 2277 KETEGSIPPTETSMSAK-----ELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSL 2326
K + +PP + E+ K+++ + L W ++ V + I K +
Sbjct: 574 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 633
Query: 2327 ENLIMEITAPDS---------QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNL 2377
+L ++ A + Q + S V V + K +E +N
Sbjct: 634 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE------QLNS 687
Query: 2378 KYEKLGGVLHER------QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2431
++ + +L ER Q ++ A N+++++ + + WL+ + ++P+
Sbjct: 688 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP---------TTPS 738
Query: 2432 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL---N 2488
+ +K+Q + K + L P+I+++K L ++ + + +
Sbjct: 739 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL------KEKGQGPMFLDADFVAFT 792
Query: 2489 SRWERATEVTVARQRQLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNML 2546
+ +++ AR+++L+ L +Q S +R W+ + E + + D ++
Sbjct: 793 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 852
Query: 2547 NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVEL 2605
+ ++Q + + ++ L+ + + P ++S + Q E + I +W +L
Sbjct: 853 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS---RKYQSEFEEIEGRWKKL 909
Query: 2606 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 2665
+ +L ++++ + K + Q +Q L + + V L + E +K+QL++
Sbjct: 910 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 969
Query: 2666 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELK----KRLETVALPLQGLEDLAAD 2721
+ SD++ + + SV G Q +K+E + RLET L D
Sbjct: 970 LLVSDIQTIQPSLN---------SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1020
Query: 2722 RI----NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEF 2777
++ L+ L T Q+ E+ W+ + + + + LQ ++E +
Sbjct: 1021 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1080
Query: 2778 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 2837
++ Q +++ S++ PP ++ L+ +L L +++ L + + L+
Sbjct: 1081 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQE-ALKKELETLTTNYQWLCTRLNGKCKTLE 1139
Query: 2838 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-KAMLNEVEKRRSL 2896
+ + ++E W+ + + K+ + S +L S + ++ E +
Sbjct: 1140 EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQ 1199
Query: 2897 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 2956
+ IL A L + DE I +E N + EE + LE+ Q +E ++S
Sbjct: 1200 IRIL---AQTLTDGGVMDEL-INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1255
Query: 2957 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3016
I++ + QL + + + + + ++ + Q L + E ++ ++ QG
Sbjct: 1256 LHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-- 1311
Query: 3017 DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADL 3076
A ++L Q +VAQ++ +V + + F R++E L ++
Sbjct: 1312 -----EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANFEQRLQESKMILDEV 1358
Query: 3077 DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3136
L + + + +QSQ+ + +K ++E R +++++ T + L
Sbjct: 1359 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1418
Query: 3137 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3196
+ AL +L + R++QLE L +++ L + A + + V
Sbjct: 1419 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1478
Query: 3197 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3256
++ ++A K QKE ++ ++ L+ + +G+ L GK + +E + +N+
Sbjct: 1479 GMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKETL--VEDKLSLLNS 1535
Query: 3257 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI--ANQKPPSAEYKVVK 3314
W + + + + L E H F ++ + W+ + L+ + +K P + V+K
Sbjct: 1536 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLK 1595
Query: 3315 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL---- 3370
L+ L+D + VD + + + + R+ + Q+ L R+ +
Sbjct: 1596 R-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1648
Query: 3371 -LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI-IR 3428
KA+ K+LE F S +K L EP+ A+IQQ + ++
Sbjct: 1649 KTGKASIPLKELEQ-----------------FNSDIQKLL---EPL---EAEIQQGVNLK 1685
Query: 3429 HKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3486
+ +D+ E++ V + ++ G +L +T ++ + K LQ +++ ++D ++
Sbjct: 1686 EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQR 1745
Query: 3487 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKDFKQDVLHRQHADHL 3539
+ + ++L L ++E KL+S+ +K+ +++ ++
Sbjct: 1746 RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK----- 1800
Query: 3540 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-----KTRYADITVTSSK 3594
EE+ ++ + ++G A+ + T ++ +++ + +A I +
Sbjct: 1801 ---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1857
Query: 3595 ALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE 3649
+ + + L + STY ++ L EVE+ L + E + + ++ K
Sbjct: 1858 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 1917
Query: 3650 LKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 3709
+K + + +D ++ A L+ R L + +S + Q++ V+ R D
Sbjct: 1918 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 1977
Query: 3710 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ-VQKAFSIDIIRHKD 3768
++++ +++ W+ E ++ L ++ ++ A+ + K I + +
Sbjct: 1978 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKWYLKELQDGIGQRQT 2034
Query: 3769 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 3828
+ L + EI + ++LQEK SL +++ + S+R RLE + ++++F
Sbjct: 2035 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2094
Query: 3829 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 3888
E W+EE IA +P +QL+++ E+++ L E + + + +L + G
Sbjct: 2095 RDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGP 2153
Query: 3889 L---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 3945
+ ++PEE + +E K ++ + ++ + ++ E +Q + + K+E +
Sbjct: 2154 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQIKDLGQLEKKLEDL 2210
Query: 3946 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4005
E L +L L + P+ +++ N+ ++++ + + +A + EE++ + Q
Sbjct: 2211 EEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2264
Query: 4006 GADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4064
K+ A + ++ KL+ + W+ + +E K D+A LTTI
Sbjct: 2265 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK-----------QPDLAPGLTTIG- 2312
Query: 4065 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4124
SP +++ Q V ET K E
Sbjct: 2313 --------ASPTQTVTLVTQPVVTKETA---------------------------ISKLE 2337
Query: 4125 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4184
+ S+ A + N+ W E + DWL + + +
Sbjct: 2338 MPSSLMLEVPALADFNRAWTE---------------------LTDWLSLLDQVIKSQRVM 2376
Query: 4185 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4244
DL + + + + K ++ Q++ ++E+L + + K +++ R II + + +++
Sbjct: 2377 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2436
Query: 4245 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4304
W+ + E + +R+ +L L Q+ A EE L L++ + I+ +
Sbjct: 2437 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2496
Query: 4305 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4364
+ + L D+ Q V+ N +LL + DD + E +N W S+ ++ E
Sbjct: 2497 ITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE 2556
Query: 4365 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQLDTHM 4418
RE L+ T + Q F ++E FL LT E+ + A++ L ++ +E +
Sbjct: 2557 REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQ 2616
Query: 4419 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4478
+L +++A + Y+ L + + +L S + S ++ + + KW + K +S
Sbjct: 2617 DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSH 2676
Query: 4479 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 4538
LE + + SLQE + WL L + L+ +P V Q + H+ F E+
Sbjct: 2677 LEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2736
Query: 4539 DQII-------------------ELDQTGNQLKFLSQKQDVV-LIKNLLVSVQSRWEKVV 4578
I+ +L Q +L + Q+V L++ V + WEK+
Sbjct: 2737 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2796
Query: 4579 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 4638
S + R +D+ +R ++ EA +L L AE S + D + L H E
Sbjct: 2797 LHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG---DLLIDSLQDHLE 2853
Query: 4639 FQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRDKWDTVCGKSVERQH 4696
K L G+ P+ + ++ T L + + L ++ +W + +R
Sbjct: 2854 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVR 2913
Query: 4697 KLEEA 4701
+L EA
Sbjct: 2914 QLHEA 2918
Score = 241 bits (614), Expect = 2e-62
Identities = 570/2964 (19%), Positives = 1185/2964 (39%), Gaps = 456/2964 (15%)
Query: 549 KAEPLTKATHSSSTSWFRKPMTRAELVA-------ISSSEDEGNL----RFVYELLSWVE 597
K+ T+A + +++ R P L A S E E NL + E+LSW+
Sbjct: 174 KSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLL 233
Query: 598 EMQMKLE-RAEWGNDLPSVELQLETQQHIHT----------SVEELGSSVKEARLYEGKM 646
+ L+ + E ND+ V+ Q T + ++ +LGS + + GK+
Sbjct: 234 SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKL----IGTGKL 289
Query: 647 SQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELI-----WLNEKEE 701
S++ T E + L +++ L+ S M +LH+ + + + WL + EE
Sbjct: 290 SEDEETEVQEQMNLLNSRWECLRVAS---MEKQSNLHRVLMDLQNQKLKELNDWLTKTEE 346
Query: 702 -------EELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAK 754
E L D D + + L +LE++Q SL ++ +
Sbjct: 347 RTRKMEEEPLGPDLEDLKRQVQQHK----VLQEDLEQEQVRVNSLTHMVVVVD------E 396
Query: 755 QTVEAYSAAVQSQLQWM----KQLCLCVEQH---VKENTAYFQFFSDARELES-FLRNLQ 806
+ + +AA++ QL+ + +C E +++ +Q ++ + L S +L +
Sbjct: 397 SSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKE 456
Query: 807 DSIKRKYSC---DHNTSLSRLEDL--LQDSMDEKEQ----LIQSKSSVASLVGRSKTIVQ 857
D++ + ++ D N LS L+ L L+ +++K+Q L K + S + ++K++ Q
Sbjct: 457 DAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL-KNKSVTQ 515
Query: 858 LKPRSPDHVL-----------KNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVI 906
D+ K+T + Q +T E V + T+ +++
Sbjct: 516 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETV---TTVTTREQIL 572
Query: 907 SPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKD 966
E + P PP K I + S + + +L V+ L SW + +
Sbjct: 573 VKHAQEELPPP-----PPQKKRQITVDSEIRK----------RLDVDITELHSW--ITRS 615
Query: 967 LDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLR-LEEEVEAC 1025
++Q+ R + ++ D L++ +++ A++ R L++ +
Sbjct: 616 EAVLQSPEFAIFRK-------------EGNFSD-LKEKVNAIEREKAEKFRKLQDASRSA 661
Query: 1026 KARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ 1085
+A + ++ N D +I+ E+ R ++ Q L S R + +Q
Sbjct: 662 QALVEQMVNEGVNAD--------------SIKQASEQLNSRWIEFCQ-LLSERLNWLEYQ 706
Query: 1086 DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPT-LRSELNLLVEKMDH 1144
+N + Q LQQL + ++ +++L P++ S PT ++S+L + ++++
Sbjct: 707 NNIIAFYNQ------LQQL----EQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNR 756
Query: 1145 VYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQE-EVVLADLSALEAHWSTL--- 1200
+ GL + +LK + ++ + + + + + V +D+ A E T+
Sbjct: 757 LSGLQP-QIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDT 815
Query: 1201 -------------RHWLSDVKDKNSV--FSVLDEEIAKAKV------------------- 1226
R W+ + K S+ SV D EI + ++
Sbjct: 816 LPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYY 875
Query: 1227 ---VAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRAC 1283
++MS+ P +YQ + +++ RW ++ +QL +LE L +
Sbjct: 876 LSTTVKEMSKKAPSEIS--RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 933
Query: 1284 HGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQY 1343
TL KW+ E + P DS +L +QL Q L ++I+ Q L+ + Q+
Sbjct: 934 IQTLKKWMAEVDVFLKEEWPALG-DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 992
Query: 1344 STIVK-DYELQLMTYKAFVESQ-----QKSPGKRRRMLSSSDAITQEFMDLRTRYTALVT 1397
+ ++ +L T + +Q Q+ ++ + + DL + +
Sbjct: 993 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1052
Query: 1398 LTTQHVK-----YISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS 1452
++++ D L++ EE K +EE Q+ KVK L V+++ A +
Sbjct: 1053 AEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1112
Query: 1453 ETKESTDIEKAILEQQVLSEELTTKKEQVSEA----------IKTSQIFLAKHGHKLSEK 1502
KE +E Q L L K + + E ++ + +L + KL
Sbjct: 1113 LKKE---LETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTT 1169
Query: 1503 EK-----KQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE 1557
E ++ISE L++L + + NQ++ L L T+ + + N ++LE
Sbjct: 1170 ENIPGGAEEISEVLDSLENLMRH-SEDNPNQIRILAQTL---TDGGVMDELIN---EELE 1222
Query: 1558 DLCS-WVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKD---- 1612
S W E A+ + + +Q + + Q+ + L +Q+ + A + D
Sbjct: 1223 TFNSRWRELHEEAV--RRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1280
Query: 1613 --IEGFMEENQTKLSPRELTALREKLH-QAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
+ ++ Q+ L+ E++ K H Q KE + + + VAQK+L++ V+ +
Sbjct: 1281 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQD-VSMKFRLFQ 1339
Query: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGY- 1728
+ + + L E+K +D ++ +LP +E S+E+ + + +
Sbjct: 1340 KPANFEQRLQESKMILD--------------EVKMHLPALET---KSVEQEVVQSQLNHC 1382
Query: 1729 MGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQK 1788
+ + ++ ++ + EM+ ++++ ++Q E + L ++
Sbjct: 1383 VNLYKSLSEVKSEVEMVIKTGRQIVQKKQT---------------------ENPKELDER 1421
Query: 1789 LGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSP 1848
+ LK Y+ A+ +Q++ +K ++ WL ++ EL P
Sbjct: 1422 VTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMP 1481
Query: 1849 ETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKD 1908
L S + + +++ K L+ +T G+ + + GK+ + LV+DKL
Sbjct: 1482 SNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV-----LGKKET----LVEDKLSL 1532
Query: 1909 ATERYTALHSKCTRLGSHLNMLLG-QYHQ--FQNSADSLQAWMQACEANVEKLLSDTVAS 1965
+ A+ S R LN+LL Q H F + D + W+ + LL ++
Sbjct: 1533 LNSNWIAVTS---RAEEWLNLLLEYQKHMETFDQNVDHITKWI----IQADTLLDESEKK 1585
Query: 1966 DPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDH-RHVQETTDSILS 2024
P Q++ K+L+ EL + + V+ + A ++M G DH R + E S L+
Sbjct: 1586 KP---QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELN 1638
Query: 2025 H-FQSLSYSL-AERSSLLQKAIAQ----SQSVQESLESLLQSIGEVEQNLEGKQVSSLSS 2078
H F ++S+ + ++S+ K + Q Q + E LE+ +Q +++ K ++ +
Sbjct: 1639 HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1698
Query: 2079 GVIQEALATNMKLKQDIARQKSSLE-ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQ 2137
G ++E L L+Q I ++ E ++ + + A + + K E+S ++ Q
Sbjct: 1699 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1758
Query: 2138 LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQEL 2197
++ + L + +++ + LAS +P + ++I+E+
Sbjct: 1759 ---------------------YKRQADDLLKCLDDIEKKLASLPEPRDE-----RKIKEI 1792
Query: 2198 NLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASS 2257
+ E++ ++E L+ + LS G A+ + + T++Q + + RE ++
Sbjct: 1793 DRELQKKKEELNAVRRQAEGLSEDGAAMAV------------EPTQIQLSKRWREIESKF 1840
Query: 2258 CQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLL---------DD 2308
Q + F + + T ++ P E S +I H+ L D
Sbjct: 1841 AQFRRLNFAQ-IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPD 1899
Query: 2309 WASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEI 2368
+K E++ + SL+N+ DS ++ + + S + T + ++
Sbjct: 1900 LCAKD--FEDLFKQEESLKNI------KDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 1951
Query: 2369 QCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMS 2428
Q +S ++ ++EK+ + +RQ + + H + QWL E+ L+
Sbjct: 1952 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI-- 2009
Query: 2429 SPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL---LVTYPNSQEAENWKKIQE 2485
P E K K +L EL+ + Q V L ++ + +A ++
Sbjct: 2010 -PENWEHAK-----YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2063
Query: 2486 ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPN 2544
LN RW+ + R+++LEE + L+ FQ ++ WL E + + + PL
Sbjct: 2064 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEPGKEQ 2121
Query: 2545 MLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE 2604
L + +QV+ +++E R+ +QLNE +L +++ +L+ N +W++
Sbjct: 2122 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIK 2181
Query: 2605 LTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV---QSAISTQPE------ 2655
++ L + +I+ I Q ++ L+DL E++ + LS Q I QP
Sbjct: 2182 VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD 2241
Query: 2656 ------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRL---- 2705
AV+ + + EI S + L E Q + +L L E + L + L
Sbjct: 2242 VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQ 2301
Query: 2706 ---------------ETVALPLQGL--EDLAADRI---NRLQAALASTQQFQQMFDELRT 2745
+TV L Q + ++ A ++ + L + + F + + EL
Sbjct: 2302 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2361
Query: 2746 WLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPG 2805
WL + LE + + + + + L Q E ++ ++L
Sbjct: 2362 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2421
Query: 2806 EEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMS 2865
E + + +++ ++N W+E+ + +R+ +L + ++ + ++ E+ + +AK+
Sbjct: 2422 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 2481
Query: 2866 ELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED-GIRDE 2921
+ T+D +Q + +K + ++ + ++ +++ N A L+ AD+ +
Sbjct: 2482 SWKEGPYTVDAIQ--KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 2539
Query: 2922 KAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ---ESFKNIEKKVEGAKHQLEIFDALG 2978
IN + ++ + + + +LEE + L++F E F + E + L+
Sbjct: 2540 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2599
Query: 2979 SQACSNKNLEKLRAQQEVLQA-LEPQVDYLRNF---TQGLVEDAPDGSDASQLLHQAEVA 3034
+K +++L Q + LQ +E D N +Q ++ DA L + +
Sbjct: 2600 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2659
Query: 3035 QQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQ 3094
++ E++++ + +E + + H ++E+ L DDEL IG D ++Q
Sbjct: 2660 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ 2719
Query: 3095 SQ---------------------IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDL 3133
Q +E VR+FL + + L E E R + EE ++
Sbjct: 2720 KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL--EKLYQEPRELPPEERAQNV 2777
Query: 3134 LG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQ 3192
L+++ E +N + KL Q +++ TL R+++ L+ AE +
Sbjct: 2778 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2837
Query: 3193 WVVG-TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3251
VG ++ + L K + E + PL+ + VN L + L + G L +
Sbjct: 2838 QPVGDLLIDSLQDHLEKVKALRGE-IAPLKENVSHVNDLARQL-TTLGIQLSPYNLS-TL 2894
Query: 3252 EEINARWNTLNKKVAQRIAQLQEA 3275
E++N RW L V R+ QL EA
Sbjct: 2895 EDLNTRWKLLQVAVEDRVRQLHEA 2918
Score = 238 bits (606), Expect = 2e-61
Identities = 494/2777 (17%), Positives = 1066/2777 (38%), Gaps = 367/2777 (13%)
Query: 1431 VKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI 1490
++E+L W+ + Q + S E + E ++ +LT + +V ++
Sbjct: 225 LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMM--DLTAHQGRVGNILQLGSK 282
Query: 1491 FLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQN 1550
+ KLSE E+ ++ EQ+N LN + L S + L + L QN
Sbjct: 283 LIGTG--KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL---------HRVLMDLQN 331
Query: 1551 TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRAT 1604
Q+L++L W+ + E + DL L++ K LQ+D++ N T
Sbjct: 332 ---QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 388
Query: 1605 SFATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVA 1653
VV + G +EE L R R L +++ L EE +
Sbjct: 389 HMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLF 448
Query: 1654 QKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLS 1713
L E + + T K E+ + +K+ L + S G+L + + L
Sbjct: 449 SAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL---KQDLL 505
Query: 1714 GASLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ 1772
K T+ ++ + + L ++ E A+ + ++ Q + T +
Sbjct: 506 STLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT-- 563
Query: 1773 HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ-DHKEFESWL 1831
+T EQ +++ E L + K+ T+ E++K L D E SW+
Sbjct: 564 ---TVTTREQILVKHAQEE--------LPPPPPQKKRQITVDSEIRKRLDVDITELHSWI 612
Query: 1832 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 1891
RSE L+ SPE ++ +++G+FS+ R +K+ D S +
Sbjct: 613 TRSEAVLQ-------SPEF--AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 663
Query: 1892 GKEPSEIGNLVKDKLKDATERYTALHSK-CTRLGSHLNMLLGQYH--QFQNSADSLQAWM 1948
E + D +K A+E+ + + C L LN L Q + F N L+
Sbjct: 664 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMT 723
Query: 1949 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2008
E ++ + T S+P ++ QL K L+ Q +E+L K+ ++ +G+
Sbjct: 724 TTAENWLK--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERL-KIQSIALKEKGQ- 779
Query: 2009 APDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI--AQSQSVQESLESLLQSIGEVEQ 2066
+ + +HF+ + + R LQ QE++ ++ + + E
Sbjct: 780 --GPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 837
Query: 2067 NLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQG 2126
L Q+S ++++ L L+ + Q+S L V + A S + Q
Sbjct: 838 KLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQS 897
Query: 2127 KLAEVSQRFEQL-------CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS 2179
+ E+ R+++L C + +E+ + L+K+ + + ++ F++ + L
Sbjct: 898 EFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD 957
Query: 2180 GNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRK 2239
+ + +Q + L +++ Q +L+++ ++ + + + ++ L
Sbjct: 958 ----SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNT 1013
Query: 2240 DFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQ 2298
+ + + V R++ E+ +K + +W+ + E + + EL+K
Sbjct: 1014 QWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA 1073
Query: 2299 IEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNG 2358
+E +K ++ K V+ + T N ++ P +Q
Sbjct: 1074 VEEMKRAKEEAQQKEAKVKLL----TESVNSVIAQAPPVAQ------------------- 1110
Query: 2359 YHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKE 2418
++ ++ + Y+ L L+ + ++L+ + E+ +WL E
Sbjct: 1111 -------EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE 1163
Query: 2419 EVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQE 2476
LK+ + + P E + +S + + E N +I+ + + L G++ N +
Sbjct: 1164 FKLKTTE--NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEE- 1220
Query: 2477 AENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVL 2536
E NSRW E V RQ+ LE+S + + ++ L + +
Sbjct: 1221 -------LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1273
Query: 2537 GPLSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQK 2593
+D + + Q++Q L E ++H Q EAAQ +L+ QK
Sbjct: 1274 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLS-------QIDVAQK 1326
Query: 2594 ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQ 2653
+LQ ++ K+ + K +++ LQ+ + V L S +
Sbjct: 1327 KLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE 1371
Query: 2654 PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK-------DELKKRLE 2706
E V+ QL + L ++ EV E+ + G Q ++ EL +R+
Sbjct: 1372 QEVVQSQLNHCVNLYKSLSEVKSEV--------EMVIKTGRQIVQKKQTENPKELDERVT 1423
Query: 2707 TVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER 2766
+ L L +R +L+ L +++ ++ + L WL + K +
Sbjct: 1424 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1483
Query: 2767 LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS 2826
L S++ + QK + + + I GE+L + G+++ ++++L L ++W ++
Sbjct: 1484 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL--GKKETLVEDKLSLLNSNWIAVT 1541
Query: 2827 KKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM 2886
+ + + L + + + + +V+ + WI + E P Q E L R KA
Sbjct: 1542 SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAE 1600
Query: 2887 LNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS--LE 2944
LN++ R + + AA+++ N + + + + +N A++ ++ S L+
Sbjct: 1601 LNDI--RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLK 1658
Query: 2945 EMTQRLREFQESFKNIEKKVE--------------------GAKHQLEIFDALGSQACSN 2984
E+ Q + Q+ + +E +++ K L+ D L +
Sbjct: 1659 ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDE 1718
Query: 2985 KNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQR 3044
+ E+++ +Q++LQ + LR+ + A ++ HQ +++ ++ +
Sbjct: 1719 RKREEIKIKQQLLQTKHNALKDLRSQRR---------KKALEISHQWYQYKRQADDLLKC 1769
Query: 3045 VNSGCVMMENKLEGIGQ--FHCRVREMFSQLADLDDELDGM--GAIGRDTDSLQSQIEDV 3100
++ +E KL + + +++E+ +L +EL+ + A G D +E
Sbjct: 1770 LDD----IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPT 1825
Query: 3101 RLFLNK-------------------IHVLK----------LDIEASE------AECRH-- 3123
++ L+K IH ++ + +E S E H
Sbjct: 1826 QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVS 1885
Query: 3124 --MLEEEGTLDLLGL-KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND 3180
+LE E L+ L ++ E L KQ E K ++ L+ + GR++ + K
Sbjct: 1886 QALLEVEQLLNAPDLCAKDFEDLFKQ----EESLKNIKDSLQQSSGRIDIIHSKKTAALQ 1941
Query: 3181 ATTAAEEA---EAL-----QWV----------------------VGTEVEIINQQLADFK 3210
+ T E EAL QW +++I NQ L + +
Sbjct: 1942 SATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE 2001
Query: 3211 MFQKEQVDP---------------------LQMKLQQVNGLGQGLIQSAGKDCDVQGLEH 3249
F ++ P Q ++ +N G+ +IQ + K D L+
Sbjct: 2002 QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK-TDASILQE 2060
Query: 3250 DMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAE 3309
+ +N RW + K+++ R +L+E +FQ L + WL + + + + P E
Sbjct: 2061 KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE 2120
Query: 3310 YKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA--DREKITGQLESLESRW 3367
+ +K ++++ KLL L R+ + L GG + SA ++ +++K+ +L+ +W
Sbjct: 2121 QQ-LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQW 2179
Query: 3368 TE----LLSKAAARQKQLEDILVLAKQFHETAEPISDFL----SVTEKKLANSEPVGTQT 3419
+ L K + Q++D+ L K+ + E ++ L + + ++P
Sbjct: 2180 IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP 2239
Query: 3420 AKIQQQIIRHKALEEDIENHATDVHQAVK-------IGQSLSSLTSP------------A 3460
+Q+ I +A + D+E + K + + L L+S A
Sbjct: 2240 FDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRA 2299
Query: 3461 EQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL-------------FGEDEVEV 3507
+Q L+ + ++ A ++ + + A+S + F E+
Sbjct: 2300 KQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTEL 2359
Query: 3508 LNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTT 3567
+WL+ ++ + S V + ++ A +++ R+ +++ I Q L +T+
Sbjct: 2360 TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTS 2419
Query: 3568 GEEV-LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEE 3626
+E +I ++++ I+ ++ ++ + L + + +T++ EE L + +
Sbjct: 2420 NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAK 2479
Query: 3627 LATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKL 3686
L + T + I + K+L K++ + + +D N+++ LL + +
Sbjct: 2480 LESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 2539
Query: 3687 VSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR--- 3743
+ N ++ + + +R ++ + QQ+ + LAW+ E + L
Sbjct: 2540 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2599
Query: 3744 --LEQDQTTAQLQVQ-KAFSIDIIRHKDSMDELFSHRSEIFGTC-GEEQKTVLQEKTESL 3799
LE + +L Q + +I H D L + +I + G + +LQ + +++
Sbjct: 2600 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2659
Query: 3800 IQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLR 3859
++ + + + LE + + + +EL W++ +++ D ++
Sbjct: 2660 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ 2719
Query: 3860 QQQEEMRQLRESIAEHKPHIDKLLKIG---------PQLKELNPEEGEM-VEEKYQKAEN 3909
+Q + R + + +P I L+ L++L E E+ EE+ Q
Sbjct: 2720 KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTR 2779
Query: 3910 MYAQIKEEVRQRALALD-EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK 3968
+ + EEV L+ + +I E ++++ + E + L +LR +I
Sbjct: 2780 LLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQP 2839
Query: 3969 IRECISDNKSATVELEK 3985
+ + + D+ +E K
Sbjct: 2840 VGDLLIDSLQDHLEKVK 2856
Score = 196 bits (498), Expect = 5e-49
Identities = 481/2824 (17%), Positives = 1126/2824 (39%), Gaps = 356/2824 (12%)
Query: 1246 QEKGSQLQERWHRV-IAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKP 1303
QE+ + L RW + +A +E +QS L + L + + L W+ +T + ++M +
Sbjct: 298 QEQMNLLNSRWECLRVASME-KQSNLHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEE 354
Query: 1304 GQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVES 1363
D L Q+ Q L ++E+ Q +++ S + +V D
Sbjct: 355 PLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN-----SLTHMVVVVD-------------- 395
Query: 1364 QQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDAL---RRLEEEEKVV 1420
+S G ++ A+ ++ L R+ + T + D L +RL EE+ +
Sbjct: 396 --ESSGDH-----ATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLF 448
Query: 1421 E---EEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTK 1477
EK++ V K+ +T G K+ ++ ++ + VL +L K
Sbjct: 449 SAWLSEKEDAVNKI------------HTTG------FKDQNEMLSSLQKLAVLKADLEKK 490
Query: 1478 KEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA 1537
K+ + + Q L S + K ++++ A + D N +Q+L+ A
Sbjct: 491 KQSMGKLYSLKQDLL-------STLKNKSVTQKTEAWLDNFARCWD---NLVQKLEKSTA 540
Query: 1538 HQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQD 1597
Q Q Q + + + + V E+ L H Q++L + +
Sbjct: 541 -QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKH----AQEELPPPPPQKKRQITVDS 595
Query: 1598 DIQNRA----TSFATVVKDIEGFMEENQTKLSPRE--LTALREKLH----QAKEQYEALQ 1647
+I+ R T + + E ++ + + +E + L+EK++ + E++ LQ
Sbjct: 596 EIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQ 655
Query: 1648 EETRVAQKELEEAVTSALQQETEKSKAAKEL----AENKKKIDALLDWVTSVGSSGGQLL 1703
+ +R AQ +E+ V + ++ K +A+++L E + + L+W+ +
Sbjct: 656 DASRSAQALVEQMVNEGVNADSIK-QASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FY 713
Query: 1704 TNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILAT 1763
L +EQ++ + + T P + Q ++ K L Q I
Sbjct: 714 NQLQQLEQMTTTAENWLKIQPT-----TPSEPTAIKSQLKICKDEVNRLSGLQPQ-IERL 767
Query: 1764 QSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFL 1821
+ L + G L + + +A K++QT+ D L ++
Sbjct: 768 KIQSIALKEKGQG-----PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQ 822
Query: 1822 QDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQK 1881
+ +W+++SE +L + E + L + + + L +++ + ++
Sbjct: 823 ETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE 882
Query: 1882 VLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSA 1941
+ K PSEI + + ++ R+ L S+ L + + + QN
Sbjct: 883 M--------SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHI 934
Query: 1942 DSLQAWMQACEANVEKLLSDT--VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 1999
+L+ WM A V+ L + D +L++QL KQ + +++ Q L V
Sbjct: 935 QTLKKWM----AEVDVFLKEEWPALGDSEILKKQL---KQCRLLVSDIQTIQPSLNSVNE 987
Query: 2000 DIMEIEGEPAPDHRHVQETT-DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2058
+I+ E P+ ET + + + + + R L+ + ++ S+Q+ L +
Sbjct: 988 GGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMH 1047
Query: 2059 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2118
+ + + E+ + + +Q+A+ + K++ ++++ ++ E V + A
Sbjct: 1048 EWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP 1107
Query: 2119 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQFMENKSRML 2177
L+ +L ++ ++ LC + K +L+++ E+ +L + E + ++
Sbjct: 1108 VAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLK 1167
Query: 2178 ASGNQPD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQ 2235
+ N P ++I+ ++ L ED + L +T+ G +D +++ ++
Sbjct: 1168 TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD----GGVMDELINEE-LE 1222
Query: 2236 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL 2295
+ EL + R+K L+ + +ETE S+ + S++ +
Sbjct: 1223 TFNSRWRELHEEAVRRQK--------------LLEQSIQSAQETEKSLHLIQESLTF--I 1266
Query: 2296 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2355
+KQ+ + D A ++I TS E + +E +QGK +
Sbjct: 1267 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHE-ISLEEMKKHNQGKEAA----------- 1314
Query: 2356 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2415
+ Q + DV++K+ L ++ + + L + + E L LE
Sbjct: 1315 ---QRVLSQIDVAQKKLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPALE 1366
Query: 2416 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2475
+K + E V++Q L + +++ V + ++ +
Sbjct: 1367 TKS------------VEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV----QKK 1410
Query: 2476 EAENWKKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELM 2532
+ EN K++ E + + E+ R++QLE+ + + L WL ++
Sbjct: 1411 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1470
Query: 2533 MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ 2592
+ + P+ L+++ + KE E ++ + + E + + T G + V+
Sbjct: 1471 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK---KETLVE 1527
Query: 2593 KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAIST 2652
+L +N W+ +T S+ ++ + +YQ+ ++ + V + + + +
Sbjct: 1528 DKLSLLNSNWIAVT-------SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1580
Query: 2653 QPEAVKQQLEET--SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVAL 2710
+ E K Q +E ++++L + +V + L G D +K +E
Sbjct: 1581 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-----DHCRKLVEPQIS 1635
Query: 2711 PLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 2770
L + RI +A++ ++ +Q +++ L+ P+ A+++ Q
Sbjct: 1636 ELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLE----------PLEAEIQ--QGV 1682
Query: 2771 LQENEEFQKSLNQ-HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKT 2829
+ E+F K +N+ + G+ + ++ G++L + ++ ++ + L+ L
Sbjct: 1683 NLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLR 1742
Query: 2830 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAM 2886
+ R+ + + + +Y+ +DL+ ++D + K++ L D +++ L + K
Sbjct: 1743 SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEE 1802
Query: 2887 LNEVEKRRSLLEILNSAADILINSSEADEDG--IRDEKAGINQNMDAVTEELQAKTGSL- 2943
LN V ++ L +A + + + I + A + A ++ +T +
Sbjct: 1803 LNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVM 1862
Query: 2944 -EEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
E+M + ++ V A LE+ L + K+ E L Q+E L+ ++
Sbjct: 1863 TEDMPLEISYVPSTYLTEITHVSQAL--LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 1920
Query: 3003 -------QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--EVKQRVNSGCVMME 3053
++D + + ++ A + ++ Q ++Q +F +V + +
Sbjct: 1921 SLQQSSGRIDIIHSKKTAALQSA---TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 1977
Query: 3054 NKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ--IEDVRLFLNKIHVLK 3111
+E +FH ++ +F+Q ++ I + + + + +++++ + + +
Sbjct: 1978 RSVEKWRRFHYDIK-IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVV 2036
Query: 3112 LDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQ----CGKLTERGKARQEQLELTLGR 3167
+ A+ E ++++ D L+ +L +LN + C +L++R K +EQ +
Sbjct: 2037 RTLNATGEE---IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI---- 2089
Query: 3168 VEDFYRKLKGLNDATTAAEEAEALQWVV---GTEVEIINQQLADFKMFQKEQVDPLQMK- 3223
+ +F R L N+ EEA+ + + G E ++ ++L K+ +E PL+
Sbjct: 2090 LSEFQRDL---NEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL--PLRQGI 2143
Query: 3224 LQQVNGLGQGLIQSAGKDCDVQG-LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF 3282
L+Q+N G ++ SA + Q LE+ +++ N +W +++ + ++ +++ + G+
Sbjct: 2144 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2203
Query: 3283 QDALEPL-------LSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVD 3335
+ LE L L WL+ + P+ E +QE ++ + ++ V+
Sbjct: 2204 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF---DVQETEIA---VQAKQPDVE 2257
Query: 3336 MLQAEGGRIAQSAELADREKITGQLESLESRW---TELLSKAAARQKQLEDIL------- 3385
+ ++G + + E + + +LE L S W LL + A+Q L L
Sbjct: 2258 EILSKGQHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 2315
Query: 3386 ----------VLAKQ---------------------FHETAEPISDFLSVTEKKLANSEP 3414
V+ K+ F+ ++D+LS+ ++ + +
Sbjct: 2316 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2375
Query: 3415 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQ 3473
+ I + II+ KA +D+E + + + Q+L + TS E + +++++I+ +Q
Sbjct: 2376 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2435
Query: 3474 ARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHR 3533
++ E+Q+ + L++ L ++ + E + E L + KL S + D + +
Sbjct: 2436 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2495
Query: 3534 QHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSS 3593
+ + L +++ + NVD A LL+ + ++ + + I + I S
Sbjct: 2496 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2555
Query: 3594 KALRTLEQARQLATKFQSTYEELTGWLREVE------EELATSGGQSPTGEQIPQFQQRQ 3647
+ LE+ +L +F E+ WL E E ++ + + + ++
Sbjct: 2556 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 2615
Query: 3648 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLV------SDANEQYKLVSDTI 3701
++L+ E+ H V ++E S+ +L R+ EG D V + N ++ +
Sbjct: 2616 QDLQGEIEAHTDVYHNLDENSQKIL-----RSLEGSDDAVLLQRRLDNMNFKWSELRKKS 2670
Query: 3702 GQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF-- 3759
++A+ + ++ + L W+ +L PI + Q V +AF
Sbjct: 2671 LNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKR 2730
Query: 3760 -----------SIDIIR------HKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQ 3801
+++ +R + +++L+ E+ + T +L+++ E +
Sbjct: 2731 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNT 2790
Query: 3802 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQ 3860
++E ++L +++ +++ + + E +EL + + + P + + L+
Sbjct: 2791 EWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQD 2850
Query: 3861 QQEEMRQLRESIAEHKPHIDKLLKIGPQLK----ELNPEEGEMVEEKYQKAENMYAQIKE 3916
E+++ LR IA K ++ + + QL +L+P +E+ + + + +++
Sbjct: 2851 HLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVED 2910
Query: 3917 EVRQ 3920
VRQ
Sbjct: 2911 RVRQ 2914
Score = 184 bits (467), Expect = 2e-45
Identities = 361/1991 (18%), Positives = 773/1991 (38%), Gaps = 283/1991 (14%)
Query: 3270 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDD 3329
+ L E+ ++ ++Q ALE +LSWL E+ + Q S + +VVK Q + L
Sbjct: 209 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 268
Query: 3330 RKATVDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTELLSKAAARQKQLEDILVL 3387
+ V + G ++ + +L++ E+ + Q+ L SRW L + A+ +KQ VL
Sbjct: 269 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL--RVASMEKQSNLHRVL 326
Query: 3388 AKQFHETAEPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3445
++ + ++D+L+ TE++ EP+G +++Q+ +HK L+ED+E V+
Sbjct: 327 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 386
Query: 3446 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 3505
+ + + L E++ L R++ I + LL L + E++
Sbjct: 387 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQC 446
Query: 3506 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA-LNEEIVNRKKNVDQAIKNGQALLK 3564
WL+E ED ++ + FK LA L ++ +K+++ + Q LL
Sbjct: 447 LFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLS 506
Query: 3565 QTTGEEVLLIQEKL--------DGIKTRYADITVTSSKALRTLEQARQLATKFQS----- 3611
+ V E D + + T S+A+ T + + T ++
Sbjct: 507 TLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 566
Query: 3612 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVME-HRLVLDTVNEVSRA 3670
T E++ ++ +EEL Q QI + +K L ++ E H + T +E
Sbjct: 567 TREQIL--VKHAQEELPPPPPQKK--RQITVDSEIRKRLDVDITELHSWI--TRSEAVLQ 620
Query: 3671 LLELVPWRAREGLDKLVSDAN-------EQYKLVSDT-------IGQRVDE---IDAAIQ 3713
E +R L N E+++ + D + Q V+E D+ Q
Sbjct: 621 SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQ 680
Query: 3714 RSQQYE-------QAADAELAWVAETKRKLMALGPIR-LEQDQTTAQ--LQVQK------ 3757
S+Q Q L W+ + ++ LEQ TTA+ L++Q
Sbjct: 681 ASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP 740
Query: 3758 -AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES-LIQQYEAISLLN----- 3810
A + KD ++ L + +I + Q L+EK + + + ++ N
Sbjct: 741 TAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQV 798
Query: 3811 -SERYARLERAQVLVN-----QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 3864
S+ AR + Q + + ++ ET + W++++ ++ D+E + Q+ E
Sbjct: 799 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 858
Query: 3865 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALA 3924
++ L+ S+ E + L + +KE++ + + KYQ EE+ R
Sbjct: 859 LQALQSSLQEQQ---SGLYYLSTTVKEMSKKAPSEISRKYQSEF-------EEIEGRWKK 908
Query: 3925 LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK--------------IR 3970
L S+Q+ E K+E + L + + ++ AEVD ++
Sbjct: 909 L------SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 962
Query: 3971 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4030
+ + + +++ +QPS ++ G+++ A+ + A++ ++ +L ++ W+ +
Sbjct: 963 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKI---KNEAEPEFASR-LETELKELNTQWDHM 1018
Query: 4031 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4090
+ R+ LE D++ + + ++ + + P +++ VE +
Sbjct: 1019 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1078
Query: 4091 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4150
KEE +++ + +I + ++K ++ + ++ L + + L
Sbjct: 1079 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1138
Query: 4151 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MPPVGTDLNTVKDQL-NEMKEFKVEVY 4206
E+ + L+ WL+ KL T +P +++ V D L N M+ +
Sbjct: 1139 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1198
Query: 4207 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4266
Q +I + L G + ++I E L W L E+ RQ LE ++ +
Sbjct: 1199 QIRILAQTLTDGGVM----------DELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1248
Query: 4267 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326
+ + +L + LT ++ L A D + E K +++D+ +H+ ++E +
Sbjct: 1249 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMK 1305
Query: 4327 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4386
K + + A + S+++ + + V K Q+ F +++
Sbjct: 1306 K------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQKPANFEQRLQES 1351
Query: 4387 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4446
+ L ++ L A + E + QL+ + LY L + ++ GR ++ +
Sbjct: 1352 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR-QIVQKK 1410
Query: 4447 DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQS 4506
+ + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + + + WL +
Sbjct: 1411 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1470
Query: 4507 LNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 4566
L S + + + S++ K E+ + + + + G LK + K++ L+++
Sbjct: 1471 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-LVEDK 1529
Query: 4567 LVSVQSRWEKVVQRS----------------------------IERGRSLDDA-RKRAKQ 4597
L + S W V R+ I+ LD++ +K+ +Q
Sbjct: 1530 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1589
Query: 4598 FHEAWKKLIDWLEDAESHLDSELE-----ISNDPD------------------------- 4627
+ K+L L D +DS + ++N D
Sbjct: 1590 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1649
Query: 4628 --KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 4685
K + L + ++F + + I+ G LKE+ + ++ + + E+ + D
Sbjct: 1650 TGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGD 1709
Query: 4686 TVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLYKVEPQLAEDQP 4731
+ + + + + E + L S + AL+ W Y+ + Q +
Sbjct: 1710 NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-YQYKRQADDLLK 1768
Query: 4732 VHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 4785
D++ + + D K+ +EL K+ + ++R L E+ V+
Sbjct: 1769 CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--AMAVEPTQ 1826
Query: 4786 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTE 4845
+LS RW + + ++ RL A Q R+ M++ E + L + T
Sbjct: 1827 IQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 1883
Query: 4846 ALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 4893
Q+L++ + E + K EE ++ ++ + + H ++
Sbjct: 1884 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 1943
Query: 4894 ITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEELLAWIQWAETT 4942
+ R + +E L+ W K Q R + ++ + ++ W+ AE
Sbjct: 1944 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2003
Query: 4943 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKS 5002
L + IP+N + K ++ +++E+ V +T
Sbjct: 2004 LRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN--------------- 2040
Query: 5003 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5062
+ G + + Q + IL + ++ L+ RWQ+V +R+++L + + L E
Sbjct: 2041 -ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEF 2093
Query: 5063 KEFANFDFDVW 5073
+ N +F +W
Sbjct: 2094 QRDLN-EFVLW 2103
Score = 92.8 bits (229), Expect = 8e-18
Identities = 47/105 (44%), Positives = 67/105 (63%), Gaps = 3/105 (2%)
Query: 198 EKLLL-WTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQI-QSNRENL 255
EK+LL W ++ T Y + NF++ WSDG NALIH +RPDL D V QS + L
Sbjct: 14 EKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRL 73
Query: 256 EQAFEVAE-RLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPK 299
E AF +A +LG+ +LLD EDVD PD+KS++ Y++S++ P+
Sbjct: 74 EHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 118
Score = 91.3 bits (225), Expect = 2e-17
Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 31/555 (5%)
Query: 4585 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 4644
G SL ++ ++ A ++++ WL AE L ++ EISND + +K Q H+ + L
Sbjct: 208 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 267
Query: 4645 GKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 4703
Q ++ G L L ED + ++ + + +W+ + S+E+Q L L+
Sbjct: 268 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 327
Query: 4704 FSGQFMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 4761
L+ L DWL K E + E++P+ DL+ + + HKV Q++L + V
Sbjct: 328 DLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 385
Query: 4762 VLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 4820
L + E+S D T ++ QL+ L RW +C+ + + L+ L + + +
Sbjct: 386 SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 445
Query: 4821 HMLLEWLSEAEQTLR--FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVI 4878
+ WLSE E + D E L SL +E+K+ + ++ + +
Sbjct: 446 CLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL-QKLAVLKADLEKKKQSMGKLYSLKQDL 504
Query: 4879 LAVCHPDCIT-TIKHWITIIRARFEEVLTWAKQHQQRLETAL--SELVANAELLEELLAW 4935
L+ +T + W+ ++ ++ ++ ++ A+ ++ + E +
Sbjct: 505 LSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 564
Query: 4936 IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIE 4992
+ E L++ QE +P + K Q ++ RK+ DVD +T+ + R
Sbjct: 565 VTTREQILVKHAQEELPPPPPQKK-----RQITVDSEIRKRLDVD-ITELHSWITRSEAV 618
Query: 4993 PTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKL 5052
F + G L + + + + +A+ R Q ++R Q + + +
Sbjct: 619 LQSPEFAIFRKEGNFSDLKE----KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 674
Query: 5053 NDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5112
D++ + E +F + + W+ + ++ ++ F+ ++ + + T + ++
Sbjct: 675 ADSIKQASEQLNSRWIEFCQLLSERLNWLEY-QNNIIAFYNQLQQLEQMTTTAENWL--- 730
Query: 5113 LASKFPTTKLEMTAV 5127
PTT E TA+
Sbjct: 731 --KIQPTTPSEPTAI 743
>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
Length = 3681
Score = 351 bits (900), Expect = 1e-95
Identities = 526/2787 (18%), Positives = 1138/2787 (40%), Gaps = 333/2787 (11%)
Query: 2222 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2281
G+ +DL HQ RV N+ + ++L T K E + + QEQ++ + E +
Sbjct: 380 GYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQS 439
Query: 2282 SIPPTETSMSAKELEKQIEHLKSLLDDWASKG---TLVEEINCKGTSLENL--------I 2330
++ + ++L++ L+DW +K T E G LE+L +
Sbjct: 440 NLHRVLMDLQNQKLKE--------LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 491
Query: 2331 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2390
++ Q + S+ V V +G H L E + D ++ + +R
Sbjct: 492 LQEDLEQEQVRVNSLTHMV-VVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRW 547
Query: 2391 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN--KAFLA 2448
LQ IL + + + +E WL KE+ + + + E + + + KA L
Sbjct: 548 VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 607
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENW-------------------KKIQEELNS 2489
+ +Q+ K+ +K+ L L +Q+ E W +I + + +
Sbjct: 608 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 667
Query: 2490 RWERATEVTVA---------------------------RQRQLEESASHLACFQAAESQL 2522
T+ TV ++RQ+ + ++L
Sbjct: 668 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 727
Query: 2523 RPWLMEKE-LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 2581
W+ E ++ + + K++V + +E + ++ + + +AQ ++
Sbjct: 728 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 787
Query: 2582 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 2641
+ ++ +++ + +N +W+E L+ R + ++ Y +L Q L +
Sbjct: 788 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQL-QQLEQMTTTAE 846
Query: 2642 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC-DELSVLIGEQYLKDE 2700
L +Q ++P A+K QL+ +C DE++ L G Q +
Sbjct: 847 NWLKIQPTTPSEPTAIKSQLK---------------------ICKDEVNRLSGLQPQIER 885
Query: 2701 LKKRLETVALPLQGLEDLAADR-----INRLQAALASTQ----------------QFQQM 2739
LK ++++AL +G + D N + + Q ++Q+
Sbjct: 886 LK--IQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQET 943
Query: 2740 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN-QHSGSYEVIVAEGESL 2798
+RTW+ +++ + E ++ +L E + Q SL Q SG Y + E
Sbjct: 944 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE-- 1001
Query: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858
+ P E R Q++ E++ W++LS + + +L++ M K +K Q H++ L W+
Sbjct: 1002 MSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMA 1061
Query: 2859 DCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-ED 2916
+ + E L D L+ L + + ++++++ + L +N + N +E +
Sbjct: 1062 EVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS 1121
Query: 2917 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFD 2975
+ E +N D + +++ A+ +L+ ++ Q+ + + + A+ + LE
Sbjct: 1122 RLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDF 1181
Query: 2976 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3035
+ K +E+++ +E Q E +V L ++ AP + + L + E
Sbjct: 1182 EYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA-LKKELETLT 1240
Query: 3036 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3095
+ + R+N C +E E +H E+ S L + L+ + + T+++
Sbjct: 1241 TNYQWLCTRLNGKCKTLE---EVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPG 1293
Query: 3096 QIEDVRLFLNKIHVLKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTE 3152
E++ L+ + L E + + R + L + G +D L + ELE N + +L E
Sbjct: 1294 GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL-INEELETFNSRWRELHE 1352
Query: 3153 RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMF 3212
RQ+ LE ++ +A+E E ++ + I++QLA +
Sbjct: 1353 EAVRRQKLLEQSI-----------------QSAQETEKSLHLIQESLTFIDKQLA---AY 1392
Query: 3213 QKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA-- 3270
++VD QM + IQS D+ E +EE+ + K+ AQR+
Sbjct: 1393 IADKVDAAQMPQEAQK------IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQ 1439
Query: 3271 ------QLQEALLHC------GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3318
+LQ+ + F+ L+ L + + + + S E +VV++Q+
Sbjct: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1499
Query: 3319 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3378
L + L + K+ V+M+ G +I Q + + +++ ++ +L+ + EL +K R+
Sbjct: 1500 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1559
Query: 3379 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3438
+QLE L L+++ + ++++L+ T+ +L V + + ++ KA +++IE
Sbjct: 1560 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1619
Query: 3439 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 3498
+ ++G++L ++ E ++ +K+ L + + + R LL + +
Sbjct: 1620 QKVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME 1678
Query: 3499 LFGEDEVEVLNWLAEVEDKLSSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 3556
F ++ + W+ + + L K K+DVL R L E+ + + VD
Sbjct: 1679 TFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTR 1731
Query: 3557 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYE 3614
L+ L++ ++ + R+A I+ + + KA L++ Q + Q E
Sbjct: 1732 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1791
Query: 3615 ELTGWLRE---VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVN 3665
L +++ ++EE + + QR L++ + + R + +
Sbjct: 1792 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1851
Query: 3666 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQ 3720
AL +L R ++ L+ +S QYK +D + + +D+I+ + R ++ +
Sbjct: 1852 TKHNALKDLRSQRRKKALE--ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK 1909
Query: 3721 AADAELAWVAETKRKLMALGPIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHR 3777
D EL ++K L +R + + + A + V+ I + + ++ F+
Sbjct: 1910 EIDREL------QKKKEELNAVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ- 1961
Query: 3778 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 3837
F Q ++E+T ++ + + + + + + +S
Sbjct: 1962 ---FRRLNFAQIHTVREETMMVMTEDMPLEI------------SYVPSTYLTEITHVSQA 2006
Query: 3838 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEE 3896
+ E L+ A D E L +Q+E ++ +++S+ + ID + K L+ P E
Sbjct: 2007 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 2066
Query: 3897 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 3956
++E + + + ++ + + R D +V + + FH I+ + L L
Sbjct: 2067 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFL 2123
Query: 3957 RMPPLIPA--EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4014
R IP E K + + + + + + Q L GEE+I +S D +
Sbjct: 2124 RKTQ-IPENWEHAKYKWYLKELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI--- 2176
Query: 4015 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4074
+Q+KL + W+++ + +R+ + + + +F D+ + +++ +I
Sbjct: 2177 -LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE 2235
Query: 4075 PGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEM 4132
PG + + K+++E + + EE L+ + G ++ + E+ ++ + +
Sbjct: 2236 PGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2294
Query: 4133 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4192
N W +++ E+ ++E ++ Q + L+ + + L++ ++ L P+ L
Sbjct: 2295 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYN 2351
Query: 4193 DQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKK--ATDETDRDI---------IRE 4237
E ++E ++ V +Q ++E++ +G+ + K+ AT R + +
Sbjct: 2352 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNR 2411
Query: 4238 PLTELKHLWENLG-----------------------EKIAHRQHKLEGALL----ALGQF 4270
L EL+ +L ++ A + ++ +L+ AL F
Sbjct: 2412 LLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADF 2471
Query: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4330
A EL WL+ ++++ +QR + GD + I + K D+ + +E + A
Sbjct: 2472 NRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 2531
Query: 4331 ELLESSAGDDASS-LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4389
L ++ +A + + R+E + W+ V + + R QQL L+ + + E+
Sbjct: 2532 NLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQV 2591
Query: 4390 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4449
L + ++L + K + ++++ +L L+ + +T + + L LL +
Sbjct: 2592 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSAD 2650
Query: 4450 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 4509
K + W + ++ ER++ LEE L +F L++F+ WLT AE + N+
Sbjct: 2651 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV 2710
Query: 4510 ---ASPPSLILNT---VLSQIEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVL 4562
A+ +L V +++ + E+ AH D LD+ + L+ L D VL
Sbjct: 2711 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 2770
Query: 4563 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 4622
++ L ++ +W ++ ++S+ L+ + + K+ H + ++L+ WL+ + L + I
Sbjct: 2771 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPI 2830
Query: 4623 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--------------KEKTLLPE 4668
D ++ Q H+ F++ L K+PV +T+ T R + + L PE
Sbjct: 2831 GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE 2890
Query: 4669 D-SQKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 4723
+ +Q + L EV +W+ + S + Q K++E L + +A L L + E
Sbjct: 2891 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2950
Query: 4724 PQLAEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 4781
QPV GDL D + + ++ K + E+ V + R+L + +
Sbjct: 2951 VIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 3009
Query: 4782 KGQLQELSTRWDTVCKLSVSKQSRLEQ 4808
L++L+TRW L V+ + R+ Q
Sbjct: 3010 LSTLEDLNTRWKL---LQVAVEDRVRQ 3033
Score = 325 bits (833), Expect = 8e-88
Identities = 518/2775 (18%), Positives = 1115/2775 (40%), Gaps = 293/2775 (10%)
Query: 2270 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL---VEEINCKGTSL 2326
++F L E+E ++ +T+ LE+ + L S D ++G + VE + + +
Sbjct: 324 KSFGSSLMESEVNLDRYQTA-----LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 378
Query: 2327 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2386
E +M++TA QG+ G+IL +G+ G + + TE+Q M+ +N ++E L
Sbjct: 379 EGYMMDLTA--HQGRVGNILQLGSKLIGT--GKLSEDEETEVQEQMNLLNSRWECLRVAS 434
Query: 2387 HERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2446
E+Q +L +L M+ +++ + WL EE + M+ E +K Q + +K
Sbjct: 435 MEKQSNLHRVL--MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVL 492
Query: 2447 LAELEQNSPKIQK------VKEALAGLLVTYPNSQE----AENWKKIQEELNSRWERATE 2496
+LEQ ++ V + +G T ++ + W I RW +
Sbjct: 493 QEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 552
Query: 2497 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQF 2555
+ + QR EE C +A WL EKE + + D N + + Q++
Sbjct: 553 ILLKWQRLTEEQ-----CLFSA------WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV 601
Query: 2556 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 2615
+ + E ++Q +L Q +L+ + S+ T + + L + + W L KL ++Q
Sbjct: 602 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSV-TQKTEAWLDNFARCWDNLVQKLEKSTAQ 660
Query: 2616 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSV-----QSAISTQPEAVKQQLEETSEIRS- 2669
I QA+ +TQ + E V V R + Q + P K+Q+ SEIR
Sbjct: 661 ISQAVT-TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 719
Query: 2670 ---DLEQLDHEVKEAQTLCD--ELSVLIGEQYLKD-------------ELKKRLETVALP 2711
D+ +L + ++ + E ++ E D E ++L+ +
Sbjct: 720 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 779
Query: 2712 LQGL------EDLAADRINRLQAALASTQ-QFQQMFDELRTWLDDK--------QSQQAK 2756
Q L E + AD I + L S +F Q+ E WL+ + Q QQ +
Sbjct: 780 AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 839
Query: 2757 NCPISA----KLE--------RLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 2804
+A K++ ++SQL+ ++ +N+ SG I +
Sbjct: 840 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---EVNRLSGLQPQIERLKIQSIALKEK 896
Query: 2805 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA--QKYQWHVEDLVPWIEDCKA 2862
G+ L V NH++++ R+ L+ +YQ + + W++ +
Sbjct: 897 GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 956
Query: 2863 KMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-EDGIR 2919
K+S +L VT D +E L +A+ + +++++S L L++ + + ++ +
Sbjct: 957 KLSIPQLSVT-DYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1015
Query: 2920 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL-EIFDALG 2978
E I ++ +L LEE +LR+ Q + ++K + L E + ALG
Sbjct: 1016 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1075
Query: 2979 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3038
K L++ R +Q ++P ++ + Q + +A + AS+L + + ++
Sbjct: 1076 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQW 1134
Query: 3039 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3098
+ Q+V + ++ LE + EM + ++E + D LQ +E
Sbjct: 1135 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1194
Query: 3099 DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ 3158
+++ + + ++ ++ + + LK+ELE L L R +
Sbjct: 1195 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1254
Query: 3159 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3218
+ LE + L+ N E + E I++ L + + D
Sbjct: 1255 KTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSED 1314
Query: 3219 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3278
Q+ L Q L D + + ++E N+RW L+++ +R L++++
Sbjct: 1315 ----NPNQIRILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI-- 1365
Query: 3279 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQI-QEQKLLQRLLDDRKATVDML 3337
+ E L + ++ I Q KV AQ+ QE + +Q L + +++ +
Sbjct: 1366 --QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM 1423
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA-- 3395
+ Q E A R +LS+ QK+L+D+ + + F + A
Sbjct: 1424 KKHN----QGKEAAQR----------------VLSQIDVAQKKLQDVSMKFRLFQKPANF 1463
Query: 3396 ----EPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3451
+ L + L E + +Q Q+ L + + ++V +K G+
Sbjct: 1464 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1523
Query: 3452 SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL 3511
+ L E++ +L+ Y+E+ + + L++ L +R ++ + WL
Sbjct: 1524 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1583
Query: 3512 AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 3571
A + +L+ + L + A A +EI +K ++ + G+AL K G++
Sbjct: 1584 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKE 1642
Query: 3572 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 3631
L+++KL + + + +T + + L L + ++ F + +T W+ + + L S
Sbjct: 1643 TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE 1702
Query: 3632 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 3691
+ P Q + K LK E+ + R +D+ + + L+ R+ ++ +S+ N
Sbjct: 1703 KKKPQ-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 1757
Query: 3692 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA 3751
++ +S I + + ++ +Q+ ++++ + E + G E+D
Sbjct: 1758 HRFAAISHRI--KTGKASIPLKELEQF----NSDIQKLLEPLEAEIQQGVNLKEEDFNKD 1811
Query: 3752 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 3811
+ + ++++ D++ + + E ++ ++ K + L ++ A+ L S
Sbjct: 1812 MNEDNEGTVKELLQRGDNLQQRITD---------ERKREEIKIKQQLLQTKHNALKDLRS 1862
Query: 3812 ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES 3871
+R + Q+ ++L +++ +A LP P D ++++ E+++ +E
Sbjct: 1863 QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEE 1921
Query: 3872 IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQ-----------IKEE--- 3917
+ + + L + G + + P + ++ +++++ E+ +AQ ++EE
Sbjct: 1922 LNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKRWREIESKFAQFRRLNFAQIHTVREETMM 1979
Query: 3918 VRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNK 3977
V + L+ + ST +TE + +LE + L++ P L + + + + K
Sbjct: 1980 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA----PDLCAKDFEDLFKQEESLK 2035
Query: 3978 SATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEER 4037
+ L++ + + + + + ++ ++Q+ L Q+ F WE + ++R
Sbjct: 2036 NIKDSLQQSSGRIDIIHSKKTAALQSATPVER----VKLQEALSQLDFQWEKVNKMYKDR 2091
Query: 4038 EIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET---IKE 4094
+ +F +E +F YD+ + + + + + P + E A+ +KE
Sbjct: 2092 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKE 2143
Query: 4095 ETDGLHEELEFIRIL---GADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE 4151
DG+ + +R L G ++I +T+ +++ + +N W+ + K +R ++LE
Sbjct: 2144 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 2203
Query: 4152 DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE 4211
+ ++Q L WL+ + ++P +K++L ++K E+ +Q
Sbjct: 2204 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 2262
Query: 4212 MEKLNHQGELMLKKAT-DETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270
+++LN G +L A ++D + L + W + + +Q ++E + LGQ
Sbjct: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2322
Query: 4271 QHALEEL-------MSWLTHTEELLDA--QRPISGDPKVIEVELAKHHVLKNDVLAHQAT 4321
+ LE+L + WL+ L+ Q G V E E+A V A Q
Sbjct: 2323 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPD 2374
Query: 4322 VETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV---LQKTEEREQQLQSTLQQAQG 4378
VE + G L + ++ +LE ++ W++V LQ+ ++ L L
Sbjct: 2375 VEEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 2432
Query: 4379 FHSEI----------EDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4428
++ ++ + M S L P A +L + L Q+ +
Sbjct: 2433 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2492
Query: 4429 -------ETYNQLLDKGRLML-------------------LSRDDSGSGSKT--EQSVAL 4460
E N+++ K + + L S ++T +
Sbjct: 2493 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 2552
Query: 4461 LEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTV 4520
++ +W V ++ R+ +L E L +T++ + +E L A L ++ +
Sbjct: 2553 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 2612
Query: 4521 LSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQR 4580
+I E K A ++ + + + +L D + + ++ + W + +R
Sbjct: 2613 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 2672
Query: 4581 SIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD------SELEISNDPDKIKLQLS 4634
ER +L++ + +QF +K + WL +AE+ + + + D +K +
Sbjct: 2673 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2732
Query: 4635 KHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
+ ++ Q + VY + + +D+ L L + KW + KS+
Sbjct: 2733 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2792
Query: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG 4754
+ LE + + +LQ L+ WL + +L+ P+ GD V D H+ F++EL
Sbjct: 2793 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 2852
Query: 4755 KRTGTV-------------------QVLKRSGRELI--ENSRDDTTWVKGQLQELSTRWD 4793
+ + + L + REL E +++ T ++ Q +E++T W+
Sbjct: 2853 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 2912
Query: 4794 TVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDT 4853
+ S Q ++++ L++ + ++ L L +AE + D LID+
Sbjct: 2913 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDS 2966
Query: 4854 HKEFMKKVEEKRVDV 4868
++ ++KV+ R ++
Sbjct: 2967 LQDHLEKVKALRGEI 2981
Score = 322 bits (826), Expect = 5e-87
Identities = 541/2849 (18%), Positives = 1142/2849 (40%), Gaps = 300/2849 (10%)
Query: 2332 EITAPDSQG--KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEK-LGGVLHE 2388
+IT +QG +T S P S + Y T D T + +K G L E
Sbjct: 273 QITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLME 332
Query: 2389 RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2448
+ +L +EEV L WL S E+ L++ +S+ E VK Q +++ ++
Sbjct: 333 SEVNLDRYQTALEEV-------LSWLLSAEDTLQAQGEISNDV--EVVKDQFHTHEGYMM 383
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEE---LNSRWERATEVTVARQRQL 2505
+L + ++ + + + L+ T S++ E ++QE+ LNSRWE ++ +Q L
Sbjct: 384 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWECLRVASMEKQSNL 441
Query: 2506 EESASHLACFQAAESQLRPWLMEKELMMGVLG--PLSIDPNMLNAQKQQVQFMLKEFEAR 2563
L + E L WL + E + PL D L Q QQ + + ++ E
Sbjct: 442 HRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQE 499
Query: 2564 RQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKS 2623
+ + L + GD + T+ ++++L+ + +W + R
Sbjct: 500 QVRVNSLTHMVVVVDESSGDHA--TAALEEQLKVLGDRWANICRWTEDR----------- 546
Query: 2624 TQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 2683
LLQD+ K + + + + SA ++ E ++ T K+
Sbjct: 547 ---WVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTG------------FKDQNE 591
Query: 2684 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDEL 2743
+ L L LK +L+K+ +++ +DL + N+ + TQ+ + D
Sbjct: 592 MLSSLQKLA---VLKADLEKKKQSMGKLYSLKQDLLSTLKNK-----SVTQKTEAWLDNF 643
Query: 2744 -RTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 2802
R W + Q + IS + Q L + + ++ + +++V + L
Sbjct: 644 ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVME-TVTTVTTREQILVKHAQEEL-PP 701
Query: 2803 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKA 2862
PP ++KR + T D + R ++ + +L WI +A
Sbjct: 702 PPPQKKRQI-----------------TVDSEIR--------KRLDVDITELHSWITRSEA 736
Query: 2863 KMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL--LEILNSAADILIN---SSEADEDG 2917
+ + + S L+ K E EK L+ + +A L+ + + D
Sbjct: 737 VLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADS 796
Query: 2918 IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDAL 2977
I+ +N + L + LE + F + +E+ A++ L+I
Sbjct: 797 IKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQLEQMTTTAENWLKIQPTT 855
Query: 2978 GSQACSNKNLEKLRAQQEV--LQALEPQVDYLRNFTQGLVE--DAPDGSDASQLLHQAEV 3033
S+ + K+ K+ + EV L L+PQ++ L+ + L E P DA +
Sbjct: 856 PSEPTAIKSQLKI-CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHF 914
Query: 3034 AQQEFLEVKQRVNSGCVMMENKLEGIGQF--HCRVREMFSQLADLDDELDGMGAIGR--- 3088
+Q F +V+ R E +L+ I R +E S + + + +I +
Sbjct: 915 -KQVFSDVQAR--------EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSV 965
Query: 3089 -DTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQC 3147
D + ++ ++ +++ + + + + + M ++ + + E E + +
Sbjct: 966 TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRW 1025
Query: 3148 GKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3207
KL+ + ++LE + ++ ++ L + +W + EI+ +QL
Sbjct: 1026 KKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLK 1085
Query: 3208 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3267
++ + + +Q L VN GQ + A + LE +++E+N +W+ + ++V
Sbjct: 1086 QCRLLVSD-IQTIQPSLNSVNEGGQKIKNEAEPEF-ASRLETELKELNTQWDHMCQQVYA 1143
Query: 3268 RIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV---VKAQIQEQKLLQ 3324
R L+ L Q L + W+ EE + EYK ++ ++E K +
Sbjct: 1144 RKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLER---DFEYKTPDELQKAVEEMKRAK 1200
Query: 3325 RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDI 3384
++A V +L + A +E + +LE+L + + L ++ + K LE++
Sbjct: 1201 EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV 1260
Query: 3385 LVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3444
+ E + +L+ E KL +E + +I + + +LE + + + +
Sbjct: 1261 WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL---DSLENLMRHSEDNPN 1317
Query: 3445 QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDE 3504
Q + Q+L+ +++E++++ +R+ E+ + R+ LL+Q++ +A+ E
Sbjct: 1318 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQET-EKS 1374
Query: 3505 VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL-L 3563
+ ++ DK + ++ D Q A + ++ + + ++++ K+ Q
Sbjct: 1375 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI--QSDLTSHEISLEEMKKHNQGKEA 1432
Query: 3564 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 3623
Q ++ + Q+KL + ++ + Q F+ +E L EV
Sbjct: 1433 AQRVLSQIDVAQKKLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEV 1477
Query: 3624 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 3683
+ L +S E + L K + E + ++ V + R +++ + L
Sbjct: 1478 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1537
Query: 3684 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 3743
D+ V+ Y + + +R +++ ++ S++ + + W+A T +L +
Sbjct: 1538 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1597
Query: 3744 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 3803
+++ KA +I + K + + +E+ GE KTVL +K E+L++
Sbjct: 1598 GMPSNLDSEVAWGKATQKEIEKQKVHLKSI----TEV----GEALKTVLGKK-ETLVE-- 1646
Query: 3804 EAISLLNSERYARLERAQVLVNQFWETYEELSPW---IEETRALIAQLPSPAIDHEQLRQ 3860
+ +SLLNS A RA+ +N E + + + ++ I Q + + E+ +
Sbjct: 1647 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1706
Query: 3861 QQEE--MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGE----MVEEKYQKAENMYAQI 3914
QQ+E +++L+ + + +P +D Q L G+ +VE + + + +A I
Sbjct: 1707 QQKEDVLKRLKAELNDIRPKVDSTRD---QAANLMANRGDHCRKLVEPQISELNHRFAAI 1763
Query: 3915 KEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE-NLSSRLRMPPLIPAEVDKIRECI 3973
++ +A ++ +F+ I+ +LE LE + + + E D ++
Sbjct: 1764 SHRIKT-----GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK-----EEDFNKDMN 1813
Query: 3974 SDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKAR 4033
DN+ EL +RG+ L Q + +EI+ K + +K
Sbjct: 1814 EDNEGTVKEL----------LQRGDNL---QQRITDERKREEIKIKQQLLQTKHNALKDL 1860
Query: 4034 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIK 4093
+R K L++ ++ LL + D + + L P D IK+ + K
Sbjct: 1861 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKK 1919
Query: 4094 EETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN-----KTWKERLE 4148
EE + + + E + GA + + + + + I+ + LN +E +
Sbjct: 1920 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1979
Query: 4149 KLEDAMQAAVQYQDTL---------QAMFDWLDNTVIKLCTMPPV-GTDLNTVKDQLNEM 4198
+ + M + Y + QA+ + V +L P + D + Q +
Sbjct: 1980 VMTEDMPLEISYVPSTYLTEITHVSQALLE-----VEQLLNAPDLCAKDFEDLFKQEESL 2034
Query: 4199 KEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQH 4258
K K + Q ++ ++ + L+ AT +R ++E L++L WE + + RQ
Sbjct: 2035 KNIKDSLQQSSGRIDIIHSKKTAALQSATP-VERVKLQEALSQLDFQWEKVNKMYKDRQG 2093
Query: 4259 KLEGALLALGQFQHALEELMSWLTHTEELL-DAQRPISGDPKVIEVELAKHHVLKNDVLA 4317
+ + ++ +F + ++ WLT E+ L Q P + + + L + L++ +
Sbjct: 2094 RFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQ 2150
Query: 4318 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4377
Q V T+N G E+++ S+ DAS L+ +L ++N W+ V ++ +R+++L+
Sbjct: 2151 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2210
Query: 4378 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4437
F ++ +F+L L ++ +++ G + +E+L+ L +L ++ QL +
Sbjct: 2211 EFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNET 2269
Query: 4438 GRLMLLSRDDSGSGS-KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4496
G +L+S S K E + +W VS + E++ ++E + + + L++
Sbjct: 2270 GGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2329
Query: 4497 -------INWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 4549
+ WL+ L I + P+ ++E ++ V A + + E+ G
Sbjct: 2330 EEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQ 2383
Query: 4550 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQ------------------------------ 4579
L +K +K L + S W+ V +
Sbjct: 2384 HL--YKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2441
Query: 4580 -----------RSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 4628
+E SL F+ AW +L DWL + + S+ + D +
Sbjct: 2442 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2501
Query: 4629 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 4688
I + K K + L ++P + I + LK KT E + + + ++++WD V
Sbjct: 2502 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2561
Query: 4689 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 4748
R+ +L E L S Q+++A + L + +L + +D + + K
Sbjct: 2562 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2621
Query: 4749 FQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLE 4807
K+L + V V +L+ + S DDT V + ++ W ++ K +++ LE
Sbjct: 2622 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2681
Query: 4808 QALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTH--KEFMKKVEEKR 4865
+ + + F + L WL+EAE T L D T + L D+ KE MK+ ++ +
Sbjct: 2682 ETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2738
Query: 4866 VDVNSAVAM--------GEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 4917
++ + + +++ ++ D ++ + + ++ E+ + + LE
Sbjct: 2739 GEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA 2798
Query: 4918 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 4977
+ + L+ELL W+Q + L + Q PI + V+ H+ F E+ K+P
Sbjct: 2799 SSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEP 2856
Query: 4978 DVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP--TPPPMPILSQSEAKNPRINQLS 5035
+ +E E+ G K +P PP + + + +++
Sbjct: 2857 VI--------MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVN 2908
Query: 5036 ARWQQVWLLALERQRKLNDALDRLEELKE 5064
W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 2909 TEWEKLNLHSADWQRKIDETLERLQELQE 2937
Score = 296 bits (757), Expect = 5e-79
Identities = 510/2885 (17%), Positives = 1162/2885 (40%), Gaps = 305/2885 (10%)
Query: 1936 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 1995
++Q + + + +W+ + E ++ +++D V+++Q T + +L HQ V +
Sbjct: 339 RYQTALEEVLSWLLSAEDTLQA--QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 396
Query: 1996 KVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLE 2055
++ ++ + VQE + + S ++ L + E+ S L + + Q+ + L+
Sbjct: 397 QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN--QKLK 454
Query: 2056 SLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFM 2113
L + + E+ + L + ++ + + L++D+ +++ + + MV
Sbjct: 455 ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVD 514
Query: 2114 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQF 2169
E++ A L+ +L + R+ +C +++ L+ +L + + S L +
Sbjct: 515 ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 574
Query: 2170 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2229
+ +++ +G + ++ Q++ L ++E +++++ L L +L S + Q
Sbjct: 575 EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 634
Query: 2230 HQDR------------VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL- 2276
+ VQ L K ++ + V + S Q + E V T ++ L
Sbjct: 635 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQP--SLTQTTVMETVTTVTTREQILV 692
Query: 2277 KETEGSIPPTETSMSAK-----ELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSL 2326
K + +PP + E+ K+++ + L W ++ V + I K +
Sbjct: 693 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 752
Query: 2327 ENLIMEITAPDS---------QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNL 2377
+L ++ A + Q + S V V + K +E +N
Sbjct: 753 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE------QLNS 806
Query: 2378 KYEKLGGVLHER------QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2431
++ + +L ER Q ++ A N+++++ + + WL+ + ++P+
Sbjct: 807 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP---------TTPS 857
Query: 2432 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL---N 2488
+ +K+Q + K + L P+I+++K L ++ + + +
Sbjct: 858 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL------KEKGQGPMFLDADFVAFT 911
Query: 2489 SRWERATEVTVARQRQLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNML 2546
+ +++ AR+++L+ L +Q S +R W+ + E + + D ++
Sbjct: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
Query: 2547 NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVEL 2605
+ ++Q + + ++ L+ + + P ++S + Q E + I +W +L
Sbjct: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS---RKYQSEFEEIEGRWKKL 1028
Query: 2606 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 2665
+ +L ++++ + K + Q +Q L + + V L + E +K+QL++
Sbjct: 1029 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1088
Query: 2666 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELK----KRLETVALPLQGLEDLAAD 2721
+ SD++ + + SV G Q +K+E + RLET L D
Sbjct: 1089 LLVSDIQTIQPSLN---------SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1139
Query: 2722 RI----NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEF 2777
++ L+ L T Q+ E+ W+ + + + + LQ ++E +
Sbjct: 1140 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1199
Query: 2778 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 2837
++ Q +++ S++ PP ++ L+ +L L +++ L + + L+
Sbjct: 1200 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQE-ALKKELETLTTNYQWLCTRLNGKCKTLE 1258
Query: 2838 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-KAMLNEVEKRRSL 2896
+ + ++E W+ + + K+ + S +L S + ++ E +
Sbjct: 1259 EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQ 1318
Query: 2897 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 2956
+ IL A L + DE I +E N + EE + LE+ Q +E ++S
Sbjct: 1319 IRIL---AQTLTDGGVMDEL-INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1374
Query: 2957 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3016
I++ + QL + + + + + ++ + Q L + E ++ ++ QG
Sbjct: 1375 LHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-- 1430
Query: 3017 DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADL 3076
A ++L Q +VAQ++ +V + + F R++E L ++
Sbjct: 1431 -----EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANFEQRLQESKMILDEV 1477
Query: 3077 DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3136
L + + + +QSQ+ + +K ++E R +++++ T + L
Sbjct: 1478 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1537
Query: 3137 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3196
+ AL +L + R++QLE L +++ L + A + + V
Sbjct: 1538 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1597
Query: 3197 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3256
++ ++A K QKE ++ ++ L+ + +G+ L GK + +E + +N+
Sbjct: 1598 GMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKETL--VEDKLSLLNS 1654
Query: 3257 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI--ANQKPPSAEYKVVK 3314
W + + + + L E H F ++ + W+ + L+ + +K P + V+K
Sbjct: 1655 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLK 1714
Query: 3315 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL---- 3370
L+ L+D + VD + + + + R+ + Q+ L R+ +
Sbjct: 1715 R-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1767
Query: 3371 -LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI-IR 3428
KA+ K+LE F S +K L EP+ A+IQQ + ++
Sbjct: 1768 KTGKASIPLKELEQ-----------------FNSDIQKLL---EPL---EAEIQQGVNLK 1804
Query: 3429 HKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3486
+ +D+ E++ V + ++ G +L +T ++ + K LQ +++ ++D ++
Sbjct: 1805 EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQR 1864
Query: 3487 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKDFKQDVLHRQHADHL 3539
+ + ++L L ++E KL+S+ +K+ +++ ++
Sbjct: 1865 RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK----- 1919
Query: 3540 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-----KTRYADITVTSSK 3594
EE+ ++ + ++G A+ + T ++ +++ + +A I +
Sbjct: 1920 ---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1976
Query: 3595 ALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE 3649
+ + + L + STY ++ L EVE+ L + E + + ++ K
Sbjct: 1977 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 2036
Query: 3650 LKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 3709
+K + + +D ++ A L+ R L + +S + Q++ V+ R D
Sbjct: 2037 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2096
Query: 3710 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ-VQKAFSIDIIRHKD 3768
++++ +++ W+ E ++ L ++ ++ A+ + K I + +
Sbjct: 2097 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKWYLKELQDGIGQRQT 2153
Query: 3769 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 3828
+ L + EI + ++LQEK SL +++ + S+R RLE + ++++F
Sbjct: 2154 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2213
Query: 3829 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 3888
E W+EE IA +P +QL+++ E+++ L E + + + +L + G
Sbjct: 2214 RDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGP 2272
Query: 3889 L---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 3945
+ ++PEE + +E K ++ + ++ + ++ E +Q + + K+E +
Sbjct: 2273 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQIKDLGQLEKKLEDL 2329
Query: 3946 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4005
E L +L L + P+ +++ N+ ++++ + + +A + EE++ + Q
Sbjct: 2330 EEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2383
Query: 4006 GADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4064
K+ A + ++ KL+ + W+ + +E K D+A LTTI
Sbjct: 2384 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK-----------QPDLAPGLTTIG- 2431
Query: 4065 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4124
SP +++ Q V ET K E
Sbjct: 2432 --------ASPTQTVTLVTQPVVTKETA---------------------------ISKLE 2456
Query: 4125 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4184
+ S+ A + N+ W E + DWL + + +
Sbjct: 2457 MPSSLMLEVPALADFNRAWTE---------------------LTDWLSLLDQVIKSQRVM 2495
Query: 4185 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4244
DL + + + + K ++ Q++ ++E+L + + K +++ R II + + +++
Sbjct: 2496 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2555
Query: 4245 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4304
W+ + E + +R+ +L L Q+ A EE L L++ + I+ +
Sbjct: 2556 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2615
Query: 4305 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4364
+ + L D+ Q V+ N +LL + DD + E +N W S+ ++ E
Sbjct: 2616 ITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE 2675
Query: 4365 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQLDTHM 4418
RE L+ T + Q F ++E FL LT E+ + A++ L ++ +E +
Sbjct: 2676 REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQ 2735
Query: 4419 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4478
+L +++A + Y+ L + + +L S + S ++ + + KW + K +S
Sbjct: 2736 DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSH 2795
Query: 4479 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 4538
LE + + SLQE + WL L + L+ +P V Q + H+ F E+
Sbjct: 2796 LEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2855
Query: 4539 DQII-------------------ELDQTGNQLKFLSQKQDVV-LIKNLLVSVQSRWEKVV 4578
I+ +L Q +L + Q+V L++ V + WEK+
Sbjct: 2856 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2915
Query: 4579 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 4638
S + R +D+ +R ++ EA +L L AE S + D + L H E
Sbjct: 2916 LHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG---DLLIDSLQDHLE 2972
Query: 4639 FQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRDKWDTVCGKSVERQH 4696
K L G+ P+ + ++ T L + + L ++ +W + +R
Sbjct: 2973 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVR 3032
Query: 4697 KLEEA 4701
+L EA
Sbjct: 3033 QLHEA 3037
Score = 241 bits (614), Expect = 2e-62
Identities = 570/2964 (19%), Positives = 1185/2964 (39%), Gaps = 456/2964 (15%)
Query: 549 KAEPLTKATHSSSTSWFRKPMTRAELVA-------ISSSEDEGNL----RFVYELLSWVE 597
K+ T+A + +++ R P L A S E E NL + E+LSW+
Sbjct: 293 KSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLL 352
Query: 598 EMQMKLE-RAEWGNDLPSVELQLETQQHIHT----------SVEELGSSVKEARLYEGKM 646
+ L+ + E ND+ V+ Q T + ++ +LGS + + GK+
Sbjct: 353 SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKL----IGTGKL 408
Query: 647 SQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELI-----WLNEKEE 701
S++ T E + L +++ L+ S M +LH+ + + + WL + EE
Sbjct: 409 SEDEETEVQEQMNLLNSRWECLRVAS---MEKQSNLHRVLMDLQNQKLKELNDWLTKTEE 465
Query: 702 -------EELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAK 754
E L D D + + L +LE++Q SL ++ +
Sbjct: 466 RTRKMEEEPLGPDLEDLKRQVQQHK----VLQEDLEQEQVRVNSLTHMVVVVD------E 515
Query: 755 QTVEAYSAAVQSQLQWM----KQLCLCVEQH---VKENTAYFQFFSDARELES-FLRNLQ 806
+ + +AA++ QL+ + +C E +++ +Q ++ + L S +L +
Sbjct: 516 SSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKE 575
Query: 807 DSIKRKYSC---DHNTSLSRLEDL--LQDSMDEKEQ----LIQSKSSVASLVGRSKTIVQ 857
D++ + ++ D N LS L+ L L+ +++K+Q L K + S + ++K++ Q
Sbjct: 576 DAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL-KNKSVTQ 634
Query: 858 LKPRSPDHVL-----------KNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVI 906
D+ K+T + Q +T E V + T+ +++
Sbjct: 635 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETV---TTVTTREQIL 691
Query: 907 SPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKD 966
E + P PP K I + S + + +L V+ L SW + +
Sbjct: 692 VKHAQEELPPP-----PPQKKRQITVDSEIRK----------RLDVDITELHSW--ITRS 734
Query: 967 LDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLR-LEEEVEAC 1025
++Q+ R + ++ D L++ +++ A++ R L++ +
Sbjct: 735 EAVLQSPEFAIFRK-------------EGNFSD-LKEKVNAIEREKAEKFRKLQDASRSA 780
Query: 1026 KARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ 1085
+A + ++ N D +I+ E+ R ++ Q L S R + +Q
Sbjct: 781 QALVEQMVNEGVNAD--------------SIKQASEQLNSRWIEFCQ-LLSERLNWLEYQ 825
Query: 1086 DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPT-LRSELNLLVEKMDH 1144
+N + Q LQQL + ++ +++L P++ S PT ++S+L + ++++
Sbjct: 826 NNIIAFYNQ------LQQL----EQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNR 875
Query: 1145 VYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQE-EVVLADLSALEAHWSTL--- 1200
+ GL + +LK + ++ + + + + + V +D+ A E T+
Sbjct: 876 LSGLQP-QIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDT 934
Query: 1201 -------------RHWLSDVKDKNSV--FSVLDEEIAKAKV------------------- 1226
R W+ + K S+ SV D EI + ++
Sbjct: 935 LPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYY 994
Query: 1227 ---VAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRAC 1283
++MS+ P +YQ + +++ RW ++ +QL +LE L +
Sbjct: 995 LSTTVKEMSKKAPSEIS--RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1052
Query: 1284 HGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQY 1343
TL KW+ E + P DS +L +QL Q L ++I+ Q L+ + Q+
Sbjct: 1053 IQTLKKWMAEVDVFLKEEWPALG-DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1111
Query: 1344 STIVK-DYELQLMTYKAFVESQ-----QKSPGKRRRMLSSSDAITQEFMDLRTRYTALVT 1397
+ ++ +L T + +Q Q+ ++ + + DL + +
Sbjct: 1112 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
Query: 1398 LTTQHVK-----YISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS 1452
++++ D L++ EE K +EE Q+ KVK L V+++ A +
Sbjct: 1172 AEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1231
Query: 1453 ETKESTDIEKAILEQQVLSEELTTKKEQVSEA----------IKTSQIFLAKHGHKLSEK 1502
KE +E Q L L K + + E ++ + +L + KL
Sbjct: 1232 LKKE---LETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTT 1288
Query: 1503 EK-----KQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE 1557
E ++ISE L++L + + NQ++ L L T+ + + N ++LE
Sbjct: 1289 ENIPGGAEEISEVLDSLENLMRH-SEDNPNQIRILAQTL---TDGGVMDELIN---EELE 1341
Query: 1558 DLCS-WVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKD---- 1612
S W E A+ + + +Q + + Q+ + L +Q+ + A + D
Sbjct: 1342 TFNSRWRELHEEAV--RRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1399
Query: 1613 --IEGFMEENQTKLSPRELTALREKLH-QAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
+ ++ Q+ L+ E++ K H Q KE + + + VAQK+L++ V+ +
Sbjct: 1400 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQD-VSMKFRLFQ 1458
Query: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGY- 1728
+ + + L E+K +D ++ +LP +E S+E+ + + +
Sbjct: 1459 KPANFEQRLQESKMILD--------------EVKMHLPALET---KSVEQEVVQSQLNHC 1501
Query: 1729 MGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQK 1788
+ + ++ ++ + EM+ ++++ ++Q E + L ++
Sbjct: 1502 VNLYKSLSEVKSEVEMVIKTGRQIVQKKQT---------------------ENPKELDER 1540
Query: 1789 LGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSP 1848
+ LK Y+ A+ +Q++ +K ++ WL ++ EL P
Sbjct: 1541 VTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMP 1600
Query: 1849 ETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKD 1908
L S + + +++ K L+ +T G+ + + GK+ + LV+DKL
Sbjct: 1601 SNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV-----LGKKET----LVEDKLSL 1651
Query: 1909 ATERYTALHSKCTRLGSHLNMLLG-QYHQ--FQNSADSLQAWMQACEANVEKLLSDTVAS 1965
+ A+ S R LN+LL Q H F + D + W+ + LL ++
Sbjct: 1652 LNSNWIAVTS---RAEEWLNLLLEYQKHMETFDQNVDHITKWI----IQADTLLDESEKK 1704
Query: 1966 DPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDH-RHVQETTDSILS 2024
P Q++ K+L+ EL + + V+ + A ++M G DH R + E S L+
Sbjct: 1705 KP---QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELN 1757
Query: 2025 H-FQSLSYSL-AERSSLLQKAIAQ----SQSVQESLESLLQSIGEVEQNLEGKQVSSLSS 2078
H F ++S+ + ++S+ K + Q Q + E LE+ +Q +++ K ++ +
Sbjct: 1758 HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1817
Query: 2079 GVIQEALATNMKLKQDIARQKSSLE-ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQ 2137
G ++E L L+Q I ++ E ++ + + A + + K E+S ++ Q
Sbjct: 1818 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1877
Query: 2138 LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQEL 2197
++ + L + +++ + LAS +P + ++I+E+
Sbjct: 1878 ---------------------YKRQADDLLKCLDDIEKKLASLPEPRDE-----RKIKEI 1911
Query: 2198 NLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASS 2257
+ E++ ++E L+ + LS G A+ + + T++Q + + RE ++
Sbjct: 1912 DRELQKKKEELNAVRRQAEGLSEDGAAMAV------------EPTQIQLSKRWREIESKF 1959
Query: 2258 CQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLL---------DD 2308
Q + F + + T ++ P E S +I H+ L D
Sbjct: 1960 AQFRRLNFAQ-IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPD 2018
Query: 2309 WASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEI 2368
+K E++ + SL+N+ DS ++ + + S + T + ++
Sbjct: 2019 LCAKD--FEDLFKQEESLKNI------KDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 2070
Query: 2369 QCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMS 2428
Q +S ++ ++EK+ + +RQ + + H + QWL E+ L+
Sbjct: 2071 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI-- 2128
Query: 2429 SPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL---LVTYPNSQEAENWKKIQE 2485
P E K K +L EL+ + Q V L ++ + +A ++
Sbjct: 2129 -PENWEHAK-----YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2182
Query: 2486 ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPN 2544
LN RW+ + R+++LEE + L+ FQ ++ WL E + + + PL
Sbjct: 2183 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEPGKEQ 2240
Query: 2545 MLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE 2604
L + +QV+ +++E R+ +QLNE +L +++ +L+ N +W++
Sbjct: 2241 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIK 2300
Query: 2605 LTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV---QSAISTQPE------ 2655
++ L + +I+ I Q ++ L+DL E++ + LS Q I QP
Sbjct: 2301 VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD 2360
Query: 2656 ------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRL---- 2705
AV+ + + EI S + L E Q + +L L E + L + L
Sbjct: 2361 VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQ 2420
Query: 2706 ---------------ETVALPLQGL--EDLAADRI---NRLQAALASTQQFQQMFDELRT 2745
+TV L Q + ++ A ++ + L + + F + + EL
Sbjct: 2421 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2480
Query: 2746 WLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPG 2805
WL + LE + + + + + L Q E ++ ++L
Sbjct: 2481 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2540
Query: 2806 EEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMS 2865
E + + +++ ++N W+E+ + +R+ +L + ++ + ++ E+ + +AK+
Sbjct: 2541 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 2600
Query: 2866 ELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED-GIRDE 2921
+ T+D +Q + +K + ++ + ++ +++ N A L+ AD+ +
Sbjct: 2601 SWKEGPYTVDAIQ--KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 2658
Query: 2922 KAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ---ESFKNIEKKVEGAKHQLEIFDALG 2978
IN + ++ + + + +LEE + L++F E F + E + L+
Sbjct: 2659 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2718
Query: 2979 SQACSNKNLEKLRAQQEVLQA-LEPQVDYLRNF---TQGLVEDAPDGSDASQLLHQAEVA 3034
+K +++L Q + LQ +E D N +Q ++ DA L + +
Sbjct: 2719 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2778
Query: 3035 QQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQ 3094
++ E++++ + +E + + H ++E+ L DDEL IG D ++Q
Sbjct: 2779 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ 2838
Query: 3095 SQ---------------------IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDL 3133
Q +E VR+FL + + L E E R + EE ++
Sbjct: 2839 KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL--EKLYQEPRELPPEERAQNV 2896
Query: 3134 LG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQ 3192
L+++ E +N + KL Q +++ TL R+++ L+ AE +
Sbjct: 2897 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2956
Query: 3193 WVVG-TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3251
VG ++ + L K + E + PL+ + VN L + L + G L +
Sbjct: 2957 QPVGDLLIDSLQDHLEKVKALRGE-IAPLKENVSHVNDLARQL-TTLGIQLSPYNLS-TL 3013
Query: 3252 EEINARWNTLNKKVAQRIAQLQEA 3275
E++N RW L V R+ QL EA
Sbjct: 3014 EDLNTRWKLLQVAVEDRVRQLHEA 3037
Score = 238 bits (606), Expect = 2e-61
Identities = 494/2777 (17%), Positives = 1066/2777 (38%), Gaps = 367/2777 (13%)
Query: 1431 VKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI 1490
++E+L W+ + Q + S E + E ++ +LT + +V ++
Sbjct: 344 LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMM--DLTAHQGRVGNILQLGSK 401
Query: 1491 FLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQN 1550
+ KLSE E+ ++ EQ+N LN + L S + L + L QN
Sbjct: 402 LIGTG--KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL---------HRVLMDLQN 450
Query: 1551 TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRAT 1604
Q+L++L W+ + E + DL L++ K LQ+D++ N T
Sbjct: 451 ---QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 507
Query: 1605 SFATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVA 1653
VV + G +EE L R R L +++ L EE +
Sbjct: 508 HMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLF 567
Query: 1654 QKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLS 1713
L E + + T K E+ + +K+ L + S G+L + + L
Sbjct: 568 SAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL---KQDLL 624
Query: 1714 GASLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ 1772
K T+ ++ + + L ++ E A+ + ++ Q + T +
Sbjct: 625 STLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT-- 682
Query: 1773 HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ-DHKEFESWL 1831
+T EQ +++ E L + K+ T+ E++K L D E SW+
Sbjct: 683 ---TVTTREQILVKHAQEE--------LPPPPPQKKRQITVDSEIRKRLDVDITELHSWI 731
Query: 1832 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 1891
RSE L+ SPE ++ +++G+FS+ R +K+ D S +
Sbjct: 732 TRSEAVLQ-------SPEF--AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 782
Query: 1892 GKEPSEIGNLVKDKLKDATERYTALHSK-CTRLGSHLNMLLGQYH--QFQNSADSLQAWM 1948
E + D +K A+E+ + + C L LN L Q + F N L+
Sbjct: 783 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMT 842
Query: 1949 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2008
E ++ + T S+P ++ QL K L+ Q +E+L K+ ++ +G+
Sbjct: 843 TTAENWLK--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERL-KIQSIALKEKGQ- 898
Query: 2009 APDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI--AQSQSVQESLESLLQSIGEVEQ 2066
+ + +HF+ + + R LQ QE++ ++ + + E
Sbjct: 899 --GPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 956
Query: 2067 NLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQG 2126
L Q+S ++++ L L+ + Q+S L V + A S + Q
Sbjct: 957 KLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQS 1016
Query: 2127 KLAEVSQRFEQL-------CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS 2179
+ E+ R+++L C + +E+ + L+K+ + + ++ F++ + L
Sbjct: 1017 EFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD 1076
Query: 2180 GNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRK 2239
+ + +Q + L +++ Q +L+++ ++ + + + ++ L
Sbjct: 1077 ----SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNT 1132
Query: 2240 DFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQ 2298
+ + + V R++ E+ +K + +W+ + E + + EL+K
Sbjct: 1133 QWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA 1192
Query: 2299 IEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNG 2358
+E +K ++ K V+ + T N ++ P +Q
Sbjct: 1193 VEEMKRAKEEAQQKEAKVKLL----TESVNSVIAQAPPVAQ------------------- 1229
Query: 2359 YHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKE 2418
++ ++ + Y+ L L+ + ++L+ + E+ +WL E
Sbjct: 1230 -------EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE 1282
Query: 2419 EVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQE 2476
LK+ + + P E + +S + + E N +I+ + + L G++ N +
Sbjct: 1283 FKLKTTE--NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEE- 1339
Query: 2477 AENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVL 2536
E NSRW E V RQ+ LE+S + + ++ L + +
Sbjct: 1340 -------LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1392
Query: 2537 GPLSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQK 2593
+D + + Q++Q L E ++H Q EAAQ +L+ QK
Sbjct: 1393 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLS-------QIDVAQK 1445
Query: 2594 ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQ 2653
+LQ ++ K+ + K +++ LQ+ + V L S +
Sbjct: 1446 KLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE 1490
Query: 2654 PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK-------DELKKRLE 2706
E V+ QL + L ++ EV E+ + G Q ++ EL +R+
Sbjct: 1491 QEVVQSQLNHCVNLYKSLSEVKSEV--------EMVIKTGRQIVQKKQTENPKELDERVT 1542
Query: 2707 TVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER 2766
+ L L +R +L+ L +++ ++ + L WL + K +
Sbjct: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602
Query: 2767 LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS 2826
L S++ + QK + + + I GE+L + G+++ ++++L L ++W ++
Sbjct: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL--GKKETLVEDKLSLLNSNWIAVT 1660
Query: 2827 KKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM 2886
+ + + L + + + + +V+ + WI + E P Q E L R KA
Sbjct: 1661 SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAE 1719
Query: 2887 LNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS--LE 2944
LN++ R + + AA+++ N + + + + +N A++ ++ S L+
Sbjct: 1720 LNDI--RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLK 1777
Query: 2945 EMTQRLREFQESFKNIEKKVE--------------------GAKHQLEIFDALGSQACSN 2984
E+ Q + Q+ + +E +++ K L+ D L +
Sbjct: 1778 ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDE 1837
Query: 2985 KNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQR 3044
+ E+++ +Q++LQ + LR+ + A ++ HQ +++ ++ +
Sbjct: 1838 RKREEIKIKQQLLQTKHNALKDLRSQRR---------KKALEISHQWYQYKRQADDLLKC 1888
Query: 3045 VNSGCVMMENKLEGIGQ--FHCRVREMFSQLADLDDELDGM--GAIGRDTDSLQSQIEDV 3100
++ +E KL + + +++E+ +L +EL+ + A G D +E
Sbjct: 1889 LDD----IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPT 1944
Query: 3101 RLFLNK-------------------IHVLK----------LDIEASE------AECRH-- 3123
++ L+K IH ++ + +E S E H
Sbjct: 1945 QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVS 2004
Query: 3124 --MLEEEGTLDLLGL-KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND 3180
+LE E L+ L ++ E L KQ E K ++ L+ + GR++ + K
Sbjct: 2005 QALLEVEQLLNAPDLCAKDFEDLFKQ----EESLKNIKDSLQQSSGRIDIIHSKKTAALQ 2060
Query: 3181 ATTAAEEA---EAL-----QWV----------------------VGTEVEIINQQLADFK 3210
+ T E EAL QW +++I NQ L + +
Sbjct: 2061 SATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE 2120
Query: 3211 MFQKEQVDP---------------------LQMKLQQVNGLGQGLIQSAGKDCDVQGLEH 3249
F ++ P Q ++ +N G+ +IQ + K D L+
Sbjct: 2121 QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK-TDASILQE 2179
Query: 3250 DMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAE 3309
+ +N RW + K+++ R +L+E +FQ L + WL + + + + P E
Sbjct: 2180 KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE 2239
Query: 3310 YKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA--DREKITGQLESLESRW 3367
+ +K ++++ KLL L R+ + L GG + SA ++ +++K+ +L+ +W
Sbjct: 2240 QQ-LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQW 2298
Query: 3368 TE----LLSKAAARQKQLEDILVLAKQFHETAEPISDFL----SVTEKKLANSEPVGTQT 3419
+ L K + Q++D+ L K+ + E ++ L + + ++P
Sbjct: 2299 IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP 2358
Query: 3420 AKIQQQIIRHKALEEDIENHATDVHQAVK-------IGQSLSSLTSP------------A 3460
+Q+ I +A + D+E + K + + L L+S A
Sbjct: 2359 FDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRA 2418
Query: 3461 EQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL-------------FGEDEVEV 3507
+Q L+ + ++ A ++ + + A+S + F E+
Sbjct: 2419 KQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTEL 2478
Query: 3508 LNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTT 3567
+WL+ ++ + S V + ++ A +++ R+ +++ I Q L +T+
Sbjct: 2479 TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTS 2538
Query: 3568 GEEV-LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEE 3626
+E +I ++++ I+ ++ ++ + L + + +T++ EE L + +
Sbjct: 2539 NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAK 2598
Query: 3627 LATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKL 3686
L + T + I + K+L K++ + + +D N+++ LL + +
Sbjct: 2599 LESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 2658
Query: 3687 VSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR--- 3743
+ N ++ + + +R ++ + QQ+ + LAW+ E + L
Sbjct: 2659 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2718
Query: 3744 --LEQDQTTAQLQVQ-KAFSIDIIRHKDSMDELFSHRSEIFGTC-GEEQKTVLQEKTESL 3799
LE + +L Q + +I H D L + +I + G + +LQ + +++
Sbjct: 2719 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2778
Query: 3800 IQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLR 3859
++ + + + LE + + + +EL W++ +++ D ++
Sbjct: 2779 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ 2838
Query: 3860 QQQEEMRQLRESIAEHKPHIDKLLKIG---------PQLKELNPEEGEM-VEEKYQKAEN 3909
+Q + R + + +P I L+ L++L E E+ EE+ Q
Sbjct: 2839 KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTR 2898
Query: 3910 MYAQIKEEVRQRALALD-EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK 3968
+ + EEV L+ + +I E ++++ + E + L +LR +I
Sbjct: 2899 LLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQP 2958
Query: 3969 IRECISDNKSATVELEK 3985
+ + + D+ +E K
Sbjct: 2959 VGDLLIDSLQDHLEKVK 2975
Score = 211 bits (537), Expect = 2e-53
Identities = 114/232 (49%), Positives = 151/232 (65%), Gaps = 5/232 (2%)
Query: 73 ADERDRVQKKTFTKWVNKHLMKVRK-HINDLYEDLRDGHNLISLLEVLSGIKLPREKGRM 131
+DER+ VQKKTFTKWVN K K HI +L+ DL+DG L+ LLE L+G KLP+EKG
Sbjct: 6 SDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST 65
Query: 132 RFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGES 191
R H L NV AL L+ V LVNI + DI DGN KLTLGLIW IILH+Q+ ++ + +
Sbjct: 66 RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMA 125
Query: 192 G-DMSAKEKLLL-WTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQI- 248
G + EK+LL W ++ T Y + NF++ WSDG NALIH +RPDL D V
Sbjct: 126 GLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQ 185
Query: 249 QSNRENLEQAFEVAE-RLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPK 299
QS + LE AF +A +LG+ +LLD EDVD PD+KS++ Y++S++ P+
Sbjct: 186 QSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 237
Score = 196 bits (498), Expect = 5e-49
Identities = 481/2824 (17%), Positives = 1126/2824 (39%), Gaps = 356/2824 (12%)
Query: 1246 QEKGSQLQERWHRV-IAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKP 1303
QE+ + L RW + +A +E +QS L + L + + L W+ +T + ++M +
Sbjct: 417 QEQMNLLNSRWECLRVASME-KQSNLHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEE 473
Query: 1304 GQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVES 1363
D L Q+ Q L ++E+ Q +++ S + +V D
Sbjct: 474 PLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN-----SLTHMVVVVD-------------- 514
Query: 1364 QQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDAL---RRLEEEEKVV 1420
+S G ++ A+ ++ L R+ + T + D L +RL EE+ +
Sbjct: 515 --ESSGDH-----ATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLF 567
Query: 1421 E---EEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTK 1477
EK++ V K+ +T G K+ ++ ++ + VL +L K
Sbjct: 568 SAWLSEKEDAVNKI------------HTTG------FKDQNEMLSSLQKLAVLKADLEKK 609
Query: 1478 KEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA 1537
K+ + + Q L S + K ++++ A + D N +Q+L+ A
Sbjct: 610 KQSMGKLYSLKQDLL-------STLKNKSVTQKTEAWLDNFARCWD---NLVQKLEKSTA 659
Query: 1538 HQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQD 1597
Q Q Q + + + + V E+ L H Q++L + +
Sbjct: 660 -QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKH----AQEELPPPPPQKKRQITVDS 714
Query: 1598 DIQNRA----TSFATVVKDIEGFMEENQTKLSPRE--LTALREKLH----QAKEQYEALQ 1647
+I+ R T + + E ++ + + +E + L+EK++ + E++ LQ
Sbjct: 715 EIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQ 774
Query: 1648 EETRVAQKELEEAVTSALQQETEKSKAAKEL----AENKKKIDALLDWVTSVGSSGGQLL 1703
+ +R AQ +E+ V + ++ K +A+++L E + + L+W+ +
Sbjct: 775 DASRSAQALVEQMVNEGVNADSIK-QASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FY 832
Query: 1704 TNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILAT 1763
L +EQ++ + + T P + Q ++ K L Q I
Sbjct: 833 NQLQQLEQMTTTAENWLKIQPT-----TPSEPTAIKSQLKICKDEVNRLSGLQPQ-IERL 886
Query: 1764 QSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFL 1821
+ L + G L + + +A K++QT+ D L ++
Sbjct: 887 KIQSIALKEKGQG-----PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQ 941
Query: 1822 QDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQK 1881
+ +W+++SE +L + E + L + + + L +++ + ++
Sbjct: 942 ETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE 1001
Query: 1882 VLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSA 1941
+ K PSEI + + ++ R+ L S+ L + + + QN
Sbjct: 1002 M--------SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHI 1053
Query: 1942 DSLQAWMQACEANVEKLLSDT--VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 1999
+L+ WM A V+ L + D +L++QL KQ + +++ Q L V
Sbjct: 1054 QTLKKWM----AEVDVFLKEEWPALGDSEILKKQL---KQCRLLVSDIQTIQPSLNSVNE 1106
Query: 2000 DIMEIEGEPAPDHRHVQETT-DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2058
+I+ E P+ ET + + + + + R L+ + ++ S+Q+ L +
Sbjct: 1107 GGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMH 1166
Query: 2059 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2118
+ + + E+ + + +Q+A+ + K++ ++++ ++ E V + A
Sbjct: 1167 EWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP 1226
Query: 2119 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQFMENKSRML 2177
L+ +L ++ ++ LC + K +L+++ E+ +L + E + ++
Sbjct: 1227 VAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLK 1286
Query: 2178 ASGNQPD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQ 2235
+ N P ++I+ ++ L ED + L +T+ G +D +++ ++
Sbjct: 1287 TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD----GGVMDELINEE-LE 1341
Query: 2236 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL 2295
+ EL + R+K L+ + +ETE S+ + S++ +
Sbjct: 1342 TFNSRWRELHEEAVRRQK--------------LLEQSIQSAQETEKSLHLIQESLTF--I 1385
Query: 2296 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2355
+KQ+ + D A ++I TS E + +E +QGK +
Sbjct: 1386 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHE-ISLEEMKKHNQGKEAA----------- 1433
Query: 2356 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2415
+ Q + DV++K+ L ++ + + L + + E L LE
Sbjct: 1434 ---QRVLSQIDVAQKKLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPALE 1485
Query: 2416 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2475
+K + E V++Q L + +++ V + ++ +
Sbjct: 1486 TKS------------VEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV----QKK 1529
Query: 2476 EAENWKKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELM 2532
+ EN K++ E + + E+ R++QLE+ + + L WL ++
Sbjct: 1530 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1589
Query: 2533 MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ 2592
+ + P+ L+++ + KE E ++ + + E + + T G + V+
Sbjct: 1590 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK---KETLVE 1646
Query: 2593 KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAIST 2652
+L +N W+ +T S+ ++ + +YQ+ ++ + V + + + +
Sbjct: 1647 DKLSLLNSNWIAVT-------SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1699
Query: 2653 QPEAVKQQLEET--SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVAL 2710
+ E K Q +E ++++L + +V + L G D +K +E
Sbjct: 1700 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-----DHCRKLVEPQIS 1754
Query: 2711 PLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 2770
L + RI +A++ ++ +Q +++ L+ P+ A+++ Q
Sbjct: 1755 ELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLE----------PLEAEIQ--QGV 1801
Query: 2771 LQENEEFQKSLNQ-HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKT 2829
+ E+F K +N+ + G+ + ++ G++L + ++ ++ + L+ L
Sbjct: 1802 NLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLR 1861
Query: 2830 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAM 2886
+ R+ + + + +Y+ +DL+ ++D + K++ L D +++ L + K
Sbjct: 1862 SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEE 1921
Query: 2887 LNEVEKRRSLLEILNSAADILINSSEADEDG--IRDEKAGINQNMDAVTEELQAKTGSL- 2943
LN V ++ L +A + + + I + A + A ++ +T +
Sbjct: 1922 LNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVM 1981
Query: 2944 -EEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
E+M + ++ V A LE+ L + K+ E L Q+E L+ ++
Sbjct: 1982 TEDMPLEISYVPSTYLTEITHVSQAL--LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 2039
Query: 3003 -------QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--EVKQRVNSGCVMME 3053
++D + + ++ A + ++ Q ++Q +F +V + +
Sbjct: 2040 SLQQSSGRIDIIHSKKTAALQSA---TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2096
Query: 3054 NKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ--IEDVRLFLNKIHVLK 3111
+E +FH ++ +F+Q ++ I + + + + +++++ + + +
Sbjct: 2097 RSVEKWRRFHYDIK-IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVV 2155
Query: 3112 LDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQ----CGKLTERGKARQEQLELTLGR 3167
+ A+ E ++++ D L+ +L +LN + C +L++R K +EQ +
Sbjct: 2156 RTLNATGEE---IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI---- 2208
Query: 3168 VEDFYRKLKGLNDATTAAEEAEALQWVV---GTEVEIINQQLADFKMFQKEQVDPLQMK- 3223
+ +F R L N+ EEA+ + + G E ++ ++L K+ +E PL+
Sbjct: 2209 LSEFQRDL---NEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL--PLRQGI 2262
Query: 3224 LQQVNGLGQGLIQSAGKDCDVQG-LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF 3282
L+Q+N G ++ SA + Q LE+ +++ N +W +++ + ++ +++ + G+
Sbjct: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2322
Query: 3283 QDALEPL-------LSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVD 3335
+ LE L L WL+ + P+ E +QE ++ + ++ V+
Sbjct: 2323 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF---DVQETEIA---VQAKQPDVE 2376
Query: 3336 MLQAEGGRIAQSAELADREKITGQLESLESRW---TELLSKAAARQKQLEDIL------- 3385
+ ++G + + E + + +LE L S W LL + A+Q L L
Sbjct: 2377 EILSKGQHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 2434
Query: 3386 ----------VLAKQ---------------------FHETAEPISDFLSVTEKKLANSEP 3414
V+ K+ F+ ++D+LS+ ++ + +
Sbjct: 2435 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2494
Query: 3415 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQ 3473
+ I + II+ KA +D+E + + + Q+L + TS E + +++++I+ +Q
Sbjct: 2495 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2554
Query: 3474 ARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHR 3533
++ E+Q+ + L++ L ++ + E + E L + KL S + D + +
Sbjct: 2555 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2614
Query: 3534 QHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSS 3593
+ + L +++ + NVD A LL+ + ++ + + I + I S
Sbjct: 2615 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2674
Query: 3594 KALRTLEQARQLATKFQSTYEELTGWLREVE------EELATSGGQSPTGEQIPQFQQRQ 3647
+ LE+ +L +F E+ WL E E ++ + + + ++
Sbjct: 2675 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 2734
Query: 3648 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLV------SDANEQYKLVSDTI 3701
++L+ E+ H V ++E S+ +L R+ EG D V + N ++ +
Sbjct: 2735 QDLQGEIEAHTDVYHNLDENSQKIL-----RSLEGSDDAVLLQRRLDNMNFKWSELRKKS 2789
Query: 3702 GQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF-- 3759
++A+ + ++ + L W+ +L PI + Q V +AF
Sbjct: 2790 LNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKR 2849
Query: 3760 -----------SIDIIR------HKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQ 3801
+++ +R + +++L+ E+ + T +L+++ E +
Sbjct: 2850 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNT 2909
Query: 3802 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQ 3860
++E ++L +++ +++ + + E +EL + + + P + + L+
Sbjct: 2910 EWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQD 2969
Query: 3861 QQEEMRQLRESIAEHKPHIDKLLKIGPQLK----ELNPEEGEMVEEKYQKAENMYAQIKE 3916
E+++ LR IA K ++ + + QL +L+P +E+ + + + +++
Sbjct: 2970 HLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVED 3029
Query: 3917 EVRQ 3920
VRQ
Sbjct: 3030 RVRQ 3033
Score = 184 bits (467), Expect = 2e-45
Identities = 361/1991 (18%), Positives = 773/1991 (38%), Gaps = 283/1991 (14%)
Query: 3270 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDD 3329
+ L E+ ++ ++Q ALE +LSWL E+ + Q S + +VVK Q + L
Sbjct: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
Query: 3330 RKATVDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTELLSKAAARQKQLEDILVL 3387
+ V + G ++ + +L++ E+ + Q+ L SRW L + A+ +KQ VL
Sbjct: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL--RVASMEKQSNLHRVL 445
Query: 3388 AKQFHETAEPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3445
++ + ++D+L+ TE++ EP+G +++Q+ +HK L+ED+E V+
Sbjct: 446 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 505
Query: 3446 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 3505
+ + + L E++ L R++ I + LL L + E++
Sbjct: 506 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQC 565
Query: 3506 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA-LNEEIVNRKKNVDQAIKNGQALLK 3564
WL+E ED ++ + FK LA L ++ +K+++ + Q LL
Sbjct: 566 LFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLS 625
Query: 3565 QTTGEEVLLIQEKL--------DGIKTRYADITVTSSKALRTLEQARQLATKFQS----- 3611
+ V E D + + T S+A+ T + + T ++
Sbjct: 626 TLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 685
Query: 3612 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVME-HRLVLDTVNEVSRA 3670
T E++ ++ +EEL Q QI + +K L ++ E H + T +E
Sbjct: 686 TREQIL--VKHAQEELPPPPPQKK--RQITVDSEIRKRLDVDITELHSWI--TRSEAVLQ 739
Query: 3671 LLELVPWRAREGLDKLVSDAN-------EQYKLVSDT-------IGQRVDE---IDAAIQ 3713
E +R L N E+++ + D + Q V+E D+ Q
Sbjct: 740 SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQ 799
Query: 3714 RSQQYE-------QAADAELAWVAETKRKLMALGPIR-LEQDQTTAQ--LQVQK------ 3757
S+Q Q L W+ + ++ LEQ TTA+ L++Q
Sbjct: 800 ASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP 859
Query: 3758 -AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES-LIQQYEAISLLN----- 3810
A + KD ++ L + +I + Q L+EK + + + ++ N
Sbjct: 860 TAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQV 917
Query: 3811 -SERYARLERAQVLVN-----QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 3864
S+ AR + Q + + ++ ET + W++++ ++ D+E + Q+ E
Sbjct: 918 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 977
Query: 3865 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALA 3924
++ L+ S+ E + L + +KE++ + + KYQ EE+ R
Sbjct: 978 LQALQSSLQEQQ---SGLYYLSTTVKEMSKKAPSEISRKYQSEF-------EEIEGRWKK 1027
Query: 3925 LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK--------------IR 3970
L S+Q+ E K+E + L + + ++ AEVD ++
Sbjct: 1028 L------SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 1081
Query: 3971 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4030
+ + + +++ +QPS ++ G+++ A+ + A++ ++ +L ++ W+ +
Sbjct: 1082 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKI---KNEAEPEFASR-LETELKELNTQWDHM 1137
Query: 4031 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4090
+ R+ LE D++ + + ++ + + P +++ VE +
Sbjct: 1138 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1197
Query: 4091 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4150
KEE +++ + +I + ++K ++ + ++ L + + L
Sbjct: 1198 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1257
Query: 4151 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MPPVGTDLNTVKDQL-NEMKEFKVEVY 4206
E+ + L+ WL+ KL T +P +++ V D L N M+ +
Sbjct: 1258 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1317
Query: 4207 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4266
Q +I + L G + ++I E L W L E+ RQ LE ++ +
Sbjct: 1318 QIRILAQTLTDGGVM----------DELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1367
Query: 4267 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326
+ + +L + LT ++ L A D + E K +++D+ +H+ ++E +
Sbjct: 1368 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMK 1424
Query: 4327 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4386
K + + A + S+++ + + V K Q+ F +++
Sbjct: 1425 K------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQKPANFEQRLQES 1470
Query: 4387 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4446
+ L ++ L A + E + QL+ + LY L + ++ GR ++ +
Sbjct: 1471 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR-QIVQKK 1529
Query: 4447 DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQS 4506
+ + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + + + WL +
Sbjct: 1530 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1589
Query: 4507 LNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 4566
L S + + + S++ K E+ + + + + G LK + K++ L+++
Sbjct: 1590 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-LVEDK 1648
Query: 4567 LVSVQSRWEKVVQRS----------------------------IERGRSLDDA-RKRAKQ 4597
L + S W V R+ I+ LD++ +K+ +Q
Sbjct: 1649 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1708
Query: 4598 FHEAWKKLIDWLEDAESHLDSELE-----ISNDPD------------------------- 4627
+ K+L L D +DS + ++N D
Sbjct: 1709 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1768
Query: 4628 --KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 4685
K + L + ++F + + I+ G LKE+ + ++ + + E+ + D
Sbjct: 1769 TGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGD 1828
Query: 4686 TVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLYKVEPQLAEDQP 4731
+ + + + + E + L S + AL+ W Y+ + Q +
Sbjct: 1829 NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-YQYKRQADDLLK 1887
Query: 4732 VHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 4785
D++ + + D K+ +EL K+ + ++R L E+ V+
Sbjct: 1888 CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--AMAVEPTQ 1945
Query: 4786 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTE 4845
+LS RW + + ++ RL A Q R+ M++ E + L + T
Sbjct: 1946 IQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 2002
Query: 4846 ALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 4893
Q+L++ + E + K EE ++ ++ + + H ++
Sbjct: 2003 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2062
Query: 4894 ITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEELLAWIQWAETT 4942
+ R + +E L+ W K Q R + ++ + ++ W+ AE
Sbjct: 2063 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2122
Query: 4943 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKS 5002
L + IP+N + K ++ +++E+ V +T
Sbjct: 2123 LRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN--------------- 2159
Query: 5003 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5062
+ G + + Q + IL + ++ L+ RWQ+V +R+++L + + L E
Sbjct: 2160 -ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEF 2212
Query: 5063 KEFANFDFDVW 5073
+ N +F +W
Sbjct: 2213 QRDLN-EFVLW 2222
Score = 91.3 bits (225), Expect = 2e-17
Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 31/555 (5%)
Query: 4585 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 4644
G SL ++ ++ A ++++ WL AE L ++ EISND + +K Q H+ + L
Sbjct: 327 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 386
Query: 4645 GKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 4703
Q ++ G L L ED + ++ + + +W+ + S+E+Q L L+
Sbjct: 387 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
Query: 4704 FSGQFMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 4761
L+ L DWL K E + E++P+ DL+ + + HKV Q++L + V
Sbjct: 447 DLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 504
Query: 4762 VLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 4820
L + E+S D T ++ QL+ L RW +C+ + + L+ L + + +
Sbjct: 505 SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 564
Query: 4821 HMLLEWLSEAEQTLR--FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVI 4878
+ WLSE E + D E L SL +E+K+ + ++ + +
Sbjct: 565 CLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL-QKLAVLKADLEKKKQSMGKLYSLKQDL 623
Query: 4879 LAVCHPDCIT-TIKHWITIIRARFEEVLTWAKQHQQRLETAL--SELVANAELLEELLAW 4935
L+ +T + W+ ++ ++ ++ ++ A+ ++ + E +
Sbjct: 624 LSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 683
Query: 4936 IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIE 4992
+ E L++ QE +P + K Q ++ RK+ DVD +T+ + R
Sbjct: 684 VTTREQILVKHAQEELPPPPPQKK-----RQITVDSEIRKRLDVD-ITELHSWITRSEAV 737
Query: 4993 PTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKL 5052
F + G L + + + + +A+ R Q ++R Q + + +
Sbjct: 738 LQSPEFAIFRKEGNFSDLKE----KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 793
Query: 5053 NDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5112
D++ + E +F + + W+ + ++ ++ F+ ++ + + T + ++
Sbjct: 794 ADSIKQASEQLNSRWIEFCQLLSERLNWLEY-QNNIIAFYNQLQQLEQMTTTAENWL--- 849
Query: 5113 LASKFPTTKLEMTAV 5127
PTT E TA+
Sbjct: 850 --KIQPTTPSEPTAI 862
>gi|5032285 dystrophin Dp427l isoform [Homo sapiens]
Length = 3562
Score = 351 bits (900), Expect = 1e-95
Identities = 526/2787 (18%), Positives = 1138/2787 (40%), Gaps = 333/2787 (11%)
Query: 2222 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2281
G+ +DL HQ RV N+ + ++L T K E + + QEQ++ + E +
Sbjct: 261 GYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQS 320
Query: 2282 SIPPTETSMSAKELEKQIEHLKSLLDDWASKG---TLVEEINCKGTSLENL--------I 2330
++ + ++L++ L+DW +K T E G LE+L +
Sbjct: 321 NLHRVLMDLQNQKLKE--------LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 372
Query: 2331 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2390
++ Q + S+ V V +G H L E + D ++ + +R
Sbjct: 373 LQEDLEQEQVRVNSLTHMV-VVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRW 428
Query: 2391 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN--KAFLA 2448
LQ IL + + + +E WL KE+ + + + E + + + KA L
Sbjct: 429 VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 488
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENW-------------------KKIQEELNS 2489
+ +Q+ K+ +K+ L L +Q+ E W +I + + +
Sbjct: 489 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 548
Query: 2490 RWERATEVTVA---------------------------RQRQLEESASHLACFQAAESQL 2522
T+ TV ++RQ+ + ++L
Sbjct: 549 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 608
Query: 2523 RPWLMEKE-LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 2581
W+ E ++ + + K++V + +E + ++ + + +AQ ++
Sbjct: 609 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 668
Query: 2582 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 2641
+ ++ +++ + +N +W+E L+ R + ++ Y +L Q L +
Sbjct: 669 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQL-QQLEQMTTTAE 727
Query: 2642 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC-DELSVLIGEQYLKDE 2700
L +Q ++P A+K QL+ +C DE++ L G Q +
Sbjct: 728 NWLKIQPTTPSEPTAIKSQLK---------------------ICKDEVNRLSGLQPQIER 766
Query: 2701 LKKRLETVALPLQGLEDLAADR-----INRLQAALASTQ----------------QFQQM 2739
LK ++++AL +G + D N + + Q ++Q+
Sbjct: 767 LK--IQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQET 824
Query: 2740 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN-QHSGSYEVIVAEGESL 2798
+RTW+ +++ + E ++ +L E + Q SL Q SG Y + E
Sbjct: 825 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE-- 882
Query: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858
+ P E R Q++ E++ W++LS + + +L++ M K +K Q H++ L W+
Sbjct: 883 MSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMA 942
Query: 2859 DCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-ED 2916
+ + E L D L+ L + + ++++++ + L +N + N +E +
Sbjct: 943 EVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS 1002
Query: 2917 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFD 2975
+ E +N D + +++ A+ +L+ ++ Q+ + + + A+ + LE
Sbjct: 1003 RLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDF 1062
Query: 2976 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3035
+ K +E+++ +E Q E +V L ++ AP + + L + E
Sbjct: 1063 EYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA-LKKELETLT 1121
Query: 3036 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3095
+ + R+N C +E E +H E+ S L + L+ + + T+++
Sbjct: 1122 TNYQWLCTRLNGKCKTLE---EVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPG 1174
Query: 3096 QIEDVRLFLNKIHVLKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTE 3152
E++ L+ + L E + + R + L + G +D L + ELE N + +L E
Sbjct: 1175 GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL-INEELETFNSRWRELHE 1233
Query: 3153 RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMF 3212
RQ+ LE ++ +A+E E ++ + I++QLA +
Sbjct: 1234 EAVRRQKLLEQSI-----------------QSAQETEKSLHLIQESLTFIDKQLA---AY 1273
Query: 3213 QKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA-- 3270
++VD QM + IQS D+ E +EE+ + K+ AQR+
Sbjct: 1274 IADKVDAAQMPQEAQK------IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQ 1320
Query: 3271 ------QLQEALLHC------GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3318
+LQ+ + F+ L+ L + + + + S E +VV++Q+
Sbjct: 1321 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1380
Query: 3319 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3378
L + L + K+ V+M+ G +I Q + + +++ ++ +L+ + EL +K R+
Sbjct: 1381 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1440
Query: 3379 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3438
+QLE L L+++ + ++++L+ T+ +L V + + ++ KA +++IE
Sbjct: 1441 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1500
Query: 3439 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 3498
+ ++G++L ++ E ++ +K+ L + + + R LL + +
Sbjct: 1501 QKVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME 1559
Query: 3499 LFGEDEVEVLNWLAEVEDKLSSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 3556
F ++ + W+ + + L K K+DVL R L E+ + + VD
Sbjct: 1560 TFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTR 1612
Query: 3557 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYE 3614
L+ L++ ++ + R+A I+ + + KA L++ Q + Q E
Sbjct: 1613 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1672
Query: 3615 ELTGWLRE---VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVN 3665
L +++ ++EE + + QR L++ + + R + +
Sbjct: 1673 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1732
Query: 3666 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQ 3720
AL +L R ++ L+ +S QYK +D + + +D+I+ + R ++ +
Sbjct: 1733 TKHNALKDLRSQRRKKALE--ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK 1790
Query: 3721 AADAELAWVAETKRKLMALGPIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHR 3777
D EL ++K L +R + + + A + V+ I + + ++ F+
Sbjct: 1791 EIDREL------QKKKEELNAVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ- 1842
Query: 3778 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 3837
F Q ++E+T ++ + + + + + + +S
Sbjct: 1843 ---FRRLNFAQIHTVREETMMVMTEDMPLEI------------SYVPSTYLTEITHVSQA 1887
Query: 3838 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEE 3896
+ E L+ A D E L +Q+E ++ +++S+ + ID + K L+ P E
Sbjct: 1888 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 1947
Query: 3897 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 3956
++E + + + ++ + + R D +V + + FH I+ + L L
Sbjct: 1948 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFL 2004
Query: 3957 RMPPLIPA--EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4014
R IP E K + + + + + + Q L GEE+I +S D +
Sbjct: 2005 RKTQ-IPENWEHAKYKWYLKELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI--- 2057
Query: 4015 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4074
+Q+KL + W+++ + +R+ + + + +F D+ + +++ +I
Sbjct: 2058 -LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE 2116
Query: 4075 PGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEM 4132
PG + + K+++E + + EE L+ + G ++ + E+ ++ + +
Sbjct: 2117 PGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2175
Query: 4133 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4192
N W +++ E+ ++E ++ Q + L+ + + L++ ++ L P+ L
Sbjct: 2176 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYN 2232
Query: 4193 DQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKK--ATDETDRDI---------IRE 4237
E ++E ++ V +Q ++E++ +G+ + K+ AT R + +
Sbjct: 2233 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNR 2292
Query: 4238 PLTELKHLWENLG-----------------------EKIAHRQHKLEGALL----ALGQF 4270
L EL+ +L ++ A + ++ +L+ AL F
Sbjct: 2293 LLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADF 2352
Query: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4330
A EL WL+ ++++ +QR + GD + I + K D+ + +E + A
Sbjct: 2353 NRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 2412
Query: 4331 ELLESSAGDDASS-LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4389
L ++ +A + + R+E + W+ V + + R QQL L+ + + E+
Sbjct: 2413 NLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQV 2472
Query: 4390 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4449
L + ++L + K + ++++ +L L+ + +T + + L LL +
Sbjct: 2473 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSAD 2531
Query: 4450 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 4509
K + W + ++ ER++ LEE L +F L++F+ WLT AE + N+
Sbjct: 2532 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV 2591
Query: 4510 ---ASPPSLILNT---VLSQIEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVL 4562
A+ +L V +++ + E+ AH D LD+ + L+ L D VL
Sbjct: 2592 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 2651
Query: 4563 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 4622
++ L ++ +W ++ ++S+ L+ + + K+ H + ++L+ WL+ + L + I
Sbjct: 2652 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPI 2711
Query: 4623 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--------------KEKTLLPE 4668
D ++ Q H+ F++ L K+PV +T+ T R + + L PE
Sbjct: 2712 GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE 2771
Query: 4669 D-SQKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 4723
+ +Q + L EV +W+ + S + Q K++E L + +A L L + E
Sbjct: 2772 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2831
Query: 4724 PQLAEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 4781
QPV GDL D + + ++ K + E+ V + R+L + +
Sbjct: 2832 VIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 2890
Query: 4782 KGQLQELSTRWDTVCKLSVSKQSRLEQ 4808
L++L+TRW L V+ + R+ Q
Sbjct: 2891 LSTLEDLNTRWKL---LQVAVEDRVRQ 2914
Score = 325 bits (833), Expect = 8e-88
Identities = 518/2775 (18%), Positives = 1115/2775 (40%), Gaps = 293/2775 (10%)
Query: 2270 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL---VEEINCKGTSL 2326
++F L E+E ++ +T+ LE+ + L S D ++G + VE + + +
Sbjct: 205 KSFGSSLMESEVNLDRYQTA-----LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 259
Query: 2327 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2386
E +M++TA QG+ G+IL +G+ G + + TE+Q M+ +N ++E L
Sbjct: 260 EGYMMDLTA--HQGRVGNILQLGSKLIGT--GKLSEDEETEVQEQMNLLNSRWECLRVAS 315
Query: 2387 HERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2446
E+Q +L +L M+ +++ + WL EE + M+ E +K Q + +K
Sbjct: 316 MEKQSNLHRVL--MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVL 373
Query: 2447 LAELEQNSPKIQK------VKEALAGLLVTYPNSQE----AENWKKIQEELNSRWERATE 2496
+LEQ ++ V + +G T ++ + W I RW +
Sbjct: 374 QEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 433
Query: 2497 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQF 2555
+ + QR EE C +A WL EKE + + D N + + Q++
Sbjct: 434 ILLKWQRLTEEQ-----CLFSA------WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV 482
Query: 2556 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 2615
+ + E ++Q +L Q +L+ + S+ T + + L + + W L KL ++Q
Sbjct: 483 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSV-TQKTEAWLDNFARCWDNLVQKLEKSTAQ 541
Query: 2616 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSV-----QSAISTQPEAVKQQLEETSEIRS- 2669
I QA+ +TQ + E V V R + Q + P K+Q+ SEIR
Sbjct: 542 ISQAVT-TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 600
Query: 2670 ---DLEQLDHEVKEAQTLCD--ELSVLIGEQYLKD-------------ELKKRLETVALP 2711
D+ +L + ++ + E ++ E D E ++L+ +
Sbjct: 601 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 660
Query: 2712 LQGL------EDLAADRINRLQAALASTQ-QFQQMFDELRTWLDDK--------QSQQAK 2756
Q L E + AD I + L S +F Q+ E WL+ + Q QQ +
Sbjct: 661 AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 720
Query: 2757 NCPISA----KLE--------RLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 2804
+A K++ ++SQL+ ++ +N+ SG I +
Sbjct: 721 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---EVNRLSGLQPQIERLKIQSIALKEK 777
Query: 2805 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA--QKYQWHVEDLVPWIEDCKA 2862
G+ L V NH++++ R+ L+ +YQ + + W++ +
Sbjct: 778 GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 837
Query: 2863 KMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-EDGIR 2919
K+S +L VT D +E L +A+ + +++++S L L++ + + ++ +
Sbjct: 838 KLSIPQLSVT-DYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 896
Query: 2920 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL-EIFDALG 2978
E I ++ +L LEE +LR+ Q + ++K + L E + ALG
Sbjct: 897 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 956
Query: 2979 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3038
K L++ R +Q ++P ++ + Q + +A + AS+L + + ++
Sbjct: 957 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQW 1015
Query: 3039 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3098
+ Q+V + ++ LE + EM + ++E + D LQ +E
Sbjct: 1016 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1075
Query: 3099 DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ 3158
+++ + + ++ ++ + + LK+ELE L L R +
Sbjct: 1076 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1135
Query: 3159 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3218
+ LE + L+ N E + E I++ L + + D
Sbjct: 1136 KTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSED 1195
Query: 3219 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3278
Q+ L Q L D + + ++E N+RW L+++ +R L++++
Sbjct: 1196 ----NPNQIRILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI-- 1246
Query: 3279 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQI-QEQKLLQRLLDDRKATVDML 3337
+ E L + ++ I Q KV AQ+ QE + +Q L + +++ +
Sbjct: 1247 --QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM 1304
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA-- 3395
+ Q E A R +LS+ QK+L+D+ + + F + A
Sbjct: 1305 KKHN----QGKEAAQR----------------VLSQIDVAQKKLQDVSMKFRLFQKPANF 1344
Query: 3396 ----EPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3451
+ L + L E + +Q Q+ L + + ++V +K G+
Sbjct: 1345 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1404
Query: 3452 SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL 3511
+ L E++ +L+ Y+E+ + + L++ L +R ++ + WL
Sbjct: 1405 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1464
Query: 3512 AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 3571
A + +L+ + L + A A +EI +K ++ + G+AL K G++
Sbjct: 1465 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKE 1523
Query: 3572 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 3631
L+++KL + + + +T + + L L + ++ F + +T W+ + + L S
Sbjct: 1524 TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE 1583
Query: 3632 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 3691
+ P Q + K LK E+ + R +D+ + + L+ R+ ++ +S+ N
Sbjct: 1584 KKKPQ-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 1638
Query: 3692 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA 3751
++ +S I + + ++ +Q+ ++++ + E + G E+D
Sbjct: 1639 HRFAAISHRI--KTGKASIPLKELEQF----NSDIQKLLEPLEAEIQQGVNLKEEDFNKD 1692
Query: 3752 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 3811
+ + ++++ D++ + + E ++ ++ K + L ++ A+ L S
Sbjct: 1693 MNEDNEGTVKELLQRGDNLQQRITD---------ERKREEIKIKQQLLQTKHNALKDLRS 1743
Query: 3812 ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES 3871
+R + Q+ ++L +++ +A LP P D ++++ E+++ +E
Sbjct: 1744 QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEE 1802
Query: 3872 IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQ-----------IKEE--- 3917
+ + + L + G + + P + ++ +++++ E+ +AQ ++EE
Sbjct: 1803 LNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKRWREIESKFAQFRRLNFAQIHTVREETMM 1860
Query: 3918 VRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNK 3977
V + L+ + ST +TE + +LE + L++ P L + + + + K
Sbjct: 1861 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA----PDLCAKDFEDLFKQEESLK 1916
Query: 3978 SATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEER 4037
+ L++ + + + + + ++ ++Q+ L Q+ F WE + ++R
Sbjct: 1917 NIKDSLQQSSGRIDIIHSKKTAALQSATPVER----VKLQEALSQLDFQWEKVNKMYKDR 1972
Query: 4038 EIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET---IKE 4094
+ +F +E +F YD+ + + + + + P + E A+ +KE
Sbjct: 1973 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKE 2024
Query: 4095 ETDGLHEELEFIRIL---GADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE 4151
DG+ + +R L G ++I +T+ +++ + +N W+ + K +R ++LE
Sbjct: 2025 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 2084
Query: 4152 DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE 4211
+ ++Q L WL+ + ++P +K++L ++K E+ +Q
Sbjct: 2085 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 2143
Query: 4212 MEKLNHQGELMLKKAT-DETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270
+++LN G +L A ++D + L + W + + +Q ++E + LGQ
Sbjct: 2144 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2203
Query: 4271 QHALEEL-------MSWLTHTEELLDA--QRPISGDPKVIEVELAKHHVLKNDVLAHQAT 4321
+ LE+L + WL+ L+ Q G V E E+A V A Q
Sbjct: 2204 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPD 2255
Query: 4322 VETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV---LQKTEEREQQLQSTLQQAQG 4378
VE + G L + ++ +LE ++ W++V LQ+ ++ L L
Sbjct: 2256 VEEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 2313
Query: 4379 FHSEI----------EDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4428
++ ++ + M S L P A +L + L Q+ +
Sbjct: 2314 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2373
Query: 4429 -------ETYNQLLDKGRLML-------------------LSRDDSGSGSKT--EQSVAL 4460
E N+++ K + + L S ++T +
Sbjct: 2374 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 2433
Query: 4461 LEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTV 4520
++ +W V ++ R+ +L E L +T++ + +E L A L ++ +
Sbjct: 2434 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 2493
Query: 4521 LSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQR 4580
+I E K A ++ + + + +L D + + ++ + W + +R
Sbjct: 2494 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 2553
Query: 4581 SIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD------SELEISNDPDKIKLQLS 4634
ER +L++ + +QF +K + WL +AE+ + + + D +K +
Sbjct: 2554 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2613
Query: 4635 KHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
+ ++ Q + VY + + +D+ L L + KW + KS+
Sbjct: 2614 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2673
Query: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG 4754
+ LE + + +LQ L+ WL + +L+ P+ GD V D H+ F++EL
Sbjct: 2674 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 2733
Query: 4755 KRTGTV-------------------QVLKRSGRELI--ENSRDDTTWVKGQLQELSTRWD 4793
+ + + L + REL E +++ T ++ Q +E++T W+
Sbjct: 2734 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 2793
Query: 4794 TVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDT 4853
+ S Q ++++ L++ + ++ L L +AE + D LID+
Sbjct: 2794 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDS 2847
Query: 4854 HKEFMKKVEEKRVDV 4868
++ ++KV+ R ++
Sbjct: 2848 LQDHLEKVKALRGEI 2862
Score = 322 bits (826), Expect = 5e-87
Identities = 541/2849 (18%), Positives = 1142/2849 (40%), Gaps = 300/2849 (10%)
Query: 2332 EITAPDSQG--KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEK-LGGVLHE 2388
+IT +QG +T S P S + Y T D T + +K G L E
Sbjct: 154 QITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLME 213
Query: 2389 RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2448
+ +L +EEV L WL S E+ L++ +S+ E VK Q +++ ++
Sbjct: 214 SEVNLDRYQTALEEV-------LSWLLSAEDTLQAQGEISNDV--EVVKDQFHTHEGYMM 264
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEE---LNSRWERATEVTVARQRQL 2505
+L + ++ + + + L+ T S++ E ++QE+ LNSRWE ++ +Q L
Sbjct: 265 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWECLRVASMEKQSNL 322
Query: 2506 EESASHLACFQAAESQLRPWLMEKELMMGVLG--PLSIDPNMLNAQKQQVQFMLKEFEAR 2563
L + E L WL + E + PL D L Q QQ + + ++ E
Sbjct: 323 HRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQE 380
Query: 2564 RQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKS 2623
+ + L + GD + T+ ++++L+ + +W + R
Sbjct: 381 QVRVNSLTHMVVVVDESSGDHA--TAALEEQLKVLGDRWANICRWTEDR----------- 427
Query: 2624 TQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 2683
LLQD+ K + + + + SA ++ E ++ T K+
Sbjct: 428 ---WVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTG------------FKDQNE 472
Query: 2684 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDEL 2743
+ L L LK +L+K+ +++ +DL + N+ + TQ+ + D
Sbjct: 473 MLSSLQKLA---VLKADLEKKKQSMGKLYSLKQDLLSTLKNK-----SVTQKTEAWLDNF 524
Query: 2744 -RTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 2802
R W + Q + IS + Q L + + ++ + +++V + L
Sbjct: 525 ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVME-TVTTVTTREQILVKHAQEEL-PP 582
Query: 2803 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKA 2862
PP ++KR + T D + R ++ + +L WI +A
Sbjct: 583 PPPQKKRQI-----------------TVDSEIR--------KRLDVDITELHSWITRSEA 617
Query: 2863 KMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL--LEILNSAADILIN---SSEADEDG 2917
+ + + S L+ K E EK L+ + +A L+ + + D
Sbjct: 618 VLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADS 677
Query: 2918 IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDAL 2977
I+ +N + L + LE + F + +E+ A++ L+I
Sbjct: 678 IKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQLEQMTTTAENWLKIQPTT 736
Query: 2978 GSQACSNKNLEKLRAQQEV--LQALEPQVDYLRNFTQGLVE--DAPDGSDASQLLHQAEV 3033
S+ + K+ K+ + EV L L+PQ++ L+ + L E P DA +
Sbjct: 737 PSEPTAIKSQLKI-CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHF 795
Query: 3034 AQQEFLEVKQRVNSGCVMMENKLEGIGQF--HCRVREMFSQLADLDDELDGMGAIGR--- 3088
+Q F +V+ R E +L+ I R +E S + + + +I +
Sbjct: 796 -KQVFSDVQAR--------EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSV 846
Query: 3089 -DTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQC 3147
D + ++ ++ +++ + + + + + M ++ + + E E + +
Sbjct: 847 TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRW 906
Query: 3148 GKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3207
KL+ + ++LE + ++ ++ L + +W + EI+ +QL
Sbjct: 907 KKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLK 966
Query: 3208 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3267
++ + + +Q L VN GQ + A + LE +++E+N +W+ + ++V
Sbjct: 967 QCRLLVSD-IQTIQPSLNSVNEGGQKIKNEAEPEF-ASRLETELKELNTQWDHMCQQVYA 1024
Query: 3268 RIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV---VKAQIQEQKLLQ 3324
R L+ L Q L + W+ EE + EYK ++ ++E K +
Sbjct: 1025 RKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLER---DFEYKTPDELQKAVEEMKRAK 1081
Query: 3325 RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDI 3384
++A V +L + A +E + +LE+L + + L ++ + K LE++
Sbjct: 1082 EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV 1141
Query: 3385 LVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3444
+ E + +L+ E KL +E + +I + + +LE + + + +
Sbjct: 1142 WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL---DSLENLMRHSEDNPN 1198
Query: 3445 QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDE 3504
Q + Q+L+ +++E++++ +R+ E+ + R+ LL+Q++ +A+ E
Sbjct: 1199 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQET-EKS 1255
Query: 3505 VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL-L 3563
+ ++ DK + ++ D Q A + ++ + + ++++ K+ Q
Sbjct: 1256 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI--QSDLTSHEISLEEMKKHNQGKEA 1313
Query: 3564 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 3623
Q ++ + Q+KL + ++ + Q F+ +E L EV
Sbjct: 1314 AQRVLSQIDVAQKKLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEV 1358
Query: 3624 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 3683
+ L +S E + L K + E + ++ V + R +++ + L
Sbjct: 1359 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1418
Query: 3684 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 3743
D+ V+ Y + + +R +++ ++ S++ + + W+A T +L +
Sbjct: 1419 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1478
Query: 3744 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 3803
+++ KA +I + K + + +E+ GE KTVL +K E+L++
Sbjct: 1479 GMPSNLDSEVAWGKATQKEIEKQKVHLKSI----TEV----GEALKTVLGKK-ETLVE-- 1527
Query: 3804 EAISLLNSERYARLERAQVLVNQFWETYEELSPW---IEETRALIAQLPSPAIDHEQLRQ 3860
+ +SLLNS A RA+ +N E + + + ++ I Q + + E+ +
Sbjct: 1528 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1587
Query: 3861 QQEE--MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGE----MVEEKYQKAENMYAQI 3914
QQ+E +++L+ + + +P +D Q L G+ +VE + + + +A I
Sbjct: 1588 QQKEDVLKRLKAELNDIRPKVDSTRD---QAANLMANRGDHCRKLVEPQISELNHRFAAI 1644
Query: 3915 KEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE-NLSSRLRMPPLIPAEVDKIRECI 3973
++ +A ++ +F+ I+ +LE LE + + + E D ++
Sbjct: 1645 SHRIKT-----GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK-----EEDFNKDMN 1694
Query: 3974 SDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKAR 4033
DN+ EL +RG+ L Q + +EI+ K + +K
Sbjct: 1695 EDNEGTVKEL----------LQRGDNL---QQRITDERKREEIKIKQQLLQTKHNALKDL 1741
Query: 4034 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIK 4093
+R K L++ ++ LL + D + + L P D IK+ + K
Sbjct: 1742 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKK 1800
Query: 4094 EETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN-----KTWKERLE 4148
EE + + + E + GA + + + + + I+ + LN +E +
Sbjct: 1801 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1860
Query: 4149 KLEDAMQAAVQYQDTL---------QAMFDWLDNTVIKLCTMPPV-GTDLNTVKDQLNEM 4198
+ + M + Y + QA+ + V +L P + D + Q +
Sbjct: 1861 VMTEDMPLEISYVPSTYLTEITHVSQALLE-----VEQLLNAPDLCAKDFEDLFKQEESL 1915
Query: 4199 KEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQH 4258
K K + Q ++ ++ + L+ AT +R ++E L++L WE + + RQ
Sbjct: 1916 KNIKDSLQQSSGRIDIIHSKKTAALQSATP-VERVKLQEALSQLDFQWEKVNKMYKDRQG 1974
Query: 4259 KLEGALLALGQFQHALEELMSWLTHTEELL-DAQRPISGDPKVIEVELAKHHVLKNDVLA 4317
+ + ++ +F + ++ WLT E+ L Q P + + + L + L++ +
Sbjct: 1975 RFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQ 2031
Query: 4318 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4377
Q V T+N G E+++ S+ DAS L+ +L ++N W+ V ++ +R+++L+
Sbjct: 2032 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2091
Query: 4378 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4437
F ++ +F+L L ++ +++ G + +E+L+ L +L ++ QL +
Sbjct: 2092 EFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNET 2150
Query: 4438 GRLMLLSRDDSGSGS-KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4496
G +L+S S K E + +W VS + E++ ++E + + + L++
Sbjct: 2151 GGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2210
Query: 4497 -------INWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 4549
+ WL+ L I + P+ ++E ++ V A + + E+ G
Sbjct: 2211 EEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQ 2264
Query: 4550 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQ------------------------------ 4579
L +K +K L + S W+ V +
Sbjct: 2265 HL--YKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2322
Query: 4580 -----------RSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 4628
+E SL F+ AW +L DWL + + S+ + D +
Sbjct: 2323 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2382
Query: 4629 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 4688
I + K K + L ++P + I + LK KT E + + + ++++WD V
Sbjct: 2383 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2442
Query: 4689 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 4748
R+ +L E L S Q+++A + L + +L + +D + + K
Sbjct: 2443 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2502
Query: 4749 FQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLE 4807
K+L + V V +L+ + S DDT V + ++ W ++ K +++ LE
Sbjct: 2503 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2562
Query: 4808 QALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTH--KEFMKKVEEKR 4865
+ + + F + L WL+EAE T L D T + L D+ KE MK+ ++ +
Sbjct: 2563 ETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2619
Query: 4866 VDVNSAVAM--------GEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 4917
++ + + +++ ++ D ++ + + ++ E+ + + LE
Sbjct: 2620 GEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA 2679
Query: 4918 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 4977
+ + L+ELL W+Q + L + Q PI + V+ H+ F E+ K+P
Sbjct: 2680 SSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEP 2737
Query: 4978 DVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP--TPPPMPILSQSEAKNPRINQLS 5035
+ +E E+ G K +P PP + + + +++
Sbjct: 2738 VI--------MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVN 2789
Query: 5036 ARWQQVWLLALERQRKLNDALDRLEELKE 5064
W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 2790 TEWEKLNLHSADWQRKIDETLERLQELQE 2818
Score = 296 bits (757), Expect = 5e-79
Identities = 510/2885 (17%), Positives = 1162/2885 (40%), Gaps = 305/2885 (10%)
Query: 1936 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 1995
++Q + + + +W+ + E ++ +++D V+++Q T + +L HQ V +
Sbjct: 220 RYQTALEEVLSWLLSAEDTLQA--QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 277
Query: 1996 KVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLE 2055
++ ++ + VQE + + S ++ L + E+ S L + + Q+ + L+
Sbjct: 278 QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN--QKLK 335
Query: 2056 SLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFM 2113
L + + E+ + L + ++ + + L++D+ +++ + + MV
Sbjct: 336 ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVD 395
Query: 2114 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQF 2169
E++ A L+ +L + R+ +C +++ L+ +L + + S L +
Sbjct: 396 ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 455
Query: 2170 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2229
+ +++ +G + ++ Q++ L ++E +++++ L L +L S + Q
Sbjct: 456 EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 515
Query: 2230 HQDR------------VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL- 2276
+ VQ L K ++ + V + S Q + E V T ++ L
Sbjct: 516 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQP--SLTQTTVMETVTTVTTREQILV 573
Query: 2277 KETEGSIPPTETSMSAK-----ELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSL 2326
K + +PP + E+ K+++ + L W ++ V + I K +
Sbjct: 574 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 633
Query: 2327 ENLIMEITAPDS---------QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNL 2377
+L ++ A + Q + S V V + K +E +N
Sbjct: 634 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE------QLNS 687
Query: 2378 KYEKLGGVLHER------QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2431
++ + +L ER Q ++ A N+++++ + + WL+ + ++P+
Sbjct: 688 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP---------TTPS 738
Query: 2432 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL---N 2488
+ +K+Q + K + L P+I+++K L ++ + + +
Sbjct: 739 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL------KEKGQGPMFLDADFVAFT 792
Query: 2489 SRWERATEVTVARQRQLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNML 2546
+ +++ AR+++L+ L +Q S +R W+ + E + + D ++
Sbjct: 793 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 852
Query: 2547 NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVEL 2605
+ ++Q + + ++ L+ + + P ++S + Q E + I +W +L
Sbjct: 853 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS---RKYQSEFEEIEGRWKKL 909
Query: 2606 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 2665
+ +L ++++ + K + Q +Q L + + V L + E +K+QL++
Sbjct: 910 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 969
Query: 2666 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELK----KRLETVALPLQGLEDLAAD 2721
+ SD++ + + SV G Q +K+E + RLET L D
Sbjct: 970 LLVSDIQTIQPSLN---------SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1020
Query: 2722 RI----NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEF 2777
++ L+ L T Q+ E+ W+ + + + + LQ ++E +
Sbjct: 1021 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1080
Query: 2778 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 2837
++ Q +++ S++ PP ++ L+ +L L +++ L + + L+
Sbjct: 1081 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQE-ALKKELETLTTNYQWLCTRLNGKCKTLE 1139
Query: 2838 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-KAMLNEVEKRRSL 2896
+ + ++E W+ + + K+ + S +L S + ++ E +
Sbjct: 1140 EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQ 1199
Query: 2897 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 2956
+ IL A L + DE I +E N + EE + LE+ Q +E ++S
Sbjct: 1200 IRIL---AQTLTDGGVMDEL-INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1255
Query: 2957 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3016
I++ + QL + + + + + ++ + Q L + E ++ ++ QG
Sbjct: 1256 LHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-- 1311
Query: 3017 DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADL 3076
A ++L Q +VAQ++ +V + + F R++E L ++
Sbjct: 1312 -----EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANFEQRLQESKMILDEV 1358
Query: 3077 DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3136
L + + + +QSQ+ + +K ++E R +++++ T + L
Sbjct: 1359 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1418
Query: 3137 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3196
+ AL +L + R++QLE L +++ L + A + + V
Sbjct: 1419 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1478
Query: 3197 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3256
++ ++A K QKE ++ ++ L+ + +G+ L GK + +E + +N+
Sbjct: 1479 GMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKETL--VEDKLSLLNS 1535
Query: 3257 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI--ANQKPPSAEYKVVK 3314
W + + + + L E H F ++ + W+ + L+ + +K P + V+K
Sbjct: 1536 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLK 1595
Query: 3315 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL---- 3370
L+ L+D + VD + + + + R+ + Q+ L R+ +
Sbjct: 1596 R-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1648
Query: 3371 -LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI-IR 3428
KA+ K+LE F S +K L EP+ A+IQQ + ++
Sbjct: 1649 KTGKASIPLKELEQ-----------------FNSDIQKLL---EPL---EAEIQQGVNLK 1685
Query: 3429 HKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3486
+ +D+ E++ V + ++ G +L +T ++ + K LQ +++ ++D ++
Sbjct: 1686 EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQR 1745
Query: 3487 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKDFKQDVLHRQHADHL 3539
+ + ++L L ++E KL+S+ +K+ +++ ++
Sbjct: 1746 RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK----- 1800
Query: 3540 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-----KTRYADITVTSSK 3594
EE+ ++ + ++G A+ + T ++ +++ + +A I +
Sbjct: 1801 ---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1857
Query: 3595 ALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE 3649
+ + + L + STY ++ L EVE+ L + E + + ++ K
Sbjct: 1858 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 1917
Query: 3650 LKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 3709
+K + + +D ++ A L+ R L + +S + Q++ V+ R D
Sbjct: 1918 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 1977
Query: 3710 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ-VQKAFSIDIIRHKD 3768
++++ +++ W+ E ++ L ++ ++ A+ + K I + +
Sbjct: 1978 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKWYLKELQDGIGQRQT 2034
Query: 3769 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 3828
+ L + EI + ++LQEK SL +++ + S+R RLE + ++++F
Sbjct: 2035 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2094
Query: 3829 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 3888
E W+EE IA +P +QL+++ E+++ L E + + + +L + G
Sbjct: 2095 RDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGP 2153
Query: 3889 L---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 3945
+ ++PEE + +E K ++ + ++ + ++ E +Q + + K+E +
Sbjct: 2154 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQIKDLGQLEKKLEDL 2210
Query: 3946 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4005
E L +L L + P+ +++ N+ ++++ + + +A + EE++ + Q
Sbjct: 2211 EEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2264
Query: 4006 GADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4064
K+ A + ++ KL+ + W+ + +E K D+A LTTI
Sbjct: 2265 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK-----------QPDLAPGLTTIG- 2312
Query: 4065 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4124
SP +++ Q V ET K E
Sbjct: 2313 --------ASPTQTVTLVTQPVVTKETA---------------------------ISKLE 2337
Query: 4125 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4184
+ S+ A + N+ W E + DWL + + +
Sbjct: 2338 MPSSLMLEVPALADFNRAWTE---------------------LTDWLSLLDQVIKSQRVM 2376
Query: 4185 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4244
DL + + + + K ++ Q++ ++E+L + + K +++ R II + + +++
Sbjct: 2377 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2436
Query: 4245 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4304
W+ + E + +R+ +L L Q+ A EE L L++ + I+ +
Sbjct: 2437 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2496
Query: 4305 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4364
+ + L D+ Q V+ N +LL + DD + E +N W S+ ++ E
Sbjct: 2497 ITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE 2556
Query: 4365 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQLDTHM 4418
RE L+ T + Q F ++E FL LT E+ + A++ L ++ +E +
Sbjct: 2557 REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQ 2616
Query: 4419 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4478
+L +++A + Y+ L + + +L S + S ++ + + KW + K +S
Sbjct: 2617 DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSH 2676
Query: 4479 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 4538
LE + + SLQE + WL L + L+ +P V Q + H+ F E+
Sbjct: 2677 LEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2736
Query: 4539 DQII-------------------ELDQTGNQLKFLSQKQDVV-LIKNLLVSVQSRWEKVV 4578
I+ +L Q +L + Q+V L++ V + WEK+
Sbjct: 2737 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2796
Query: 4579 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 4638
S + R +D+ +R ++ EA +L L AE S + D + L H E
Sbjct: 2797 LHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG---DLLIDSLQDHLE 2853
Query: 4639 FQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRDKWDTVCGKSVERQH 4696
K L G+ P+ + ++ T L + + L ++ +W + +R
Sbjct: 2854 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVR 2913
Query: 4697 KLEEA 4701
+L EA
Sbjct: 2914 QLHEA 2918
Score = 241 bits (614), Expect = 2e-62
Identities = 570/2964 (19%), Positives = 1185/2964 (39%), Gaps = 456/2964 (15%)
Query: 549 KAEPLTKATHSSSTSWFRKPMTRAELVA-------ISSSEDEGNL----RFVYELLSWVE 597
K+ T+A + +++ R P L A S E E NL + E+LSW+
Sbjct: 174 KSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLL 233
Query: 598 EMQMKLE-RAEWGNDLPSVELQLETQQHIHT----------SVEELGSSVKEARLYEGKM 646
+ L+ + E ND+ V+ Q T + ++ +LGS + + GK+
Sbjct: 234 SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKL----IGTGKL 289
Query: 647 SQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELI-----WLNEKEE 701
S++ T E + L +++ L+ S M +LH+ + + + WL + EE
Sbjct: 290 SEDEETEVQEQMNLLNSRWECLRVAS---MEKQSNLHRVLMDLQNQKLKELNDWLTKTEE 346
Query: 702 -------EELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAK 754
E L D D + + L +LE++Q SL ++ +
Sbjct: 347 RTRKMEEEPLGPDLEDLKRQVQQHK----VLQEDLEQEQVRVNSLTHMVVVVD------E 396
Query: 755 QTVEAYSAAVQSQLQWM----KQLCLCVEQH---VKENTAYFQFFSDARELES-FLRNLQ 806
+ + +AA++ QL+ + +C E +++ +Q ++ + L S +L +
Sbjct: 397 SSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKE 456
Query: 807 DSIKRKYSC---DHNTSLSRLEDL--LQDSMDEKEQ----LIQSKSSVASLVGRSKTIVQ 857
D++ + ++ D N LS L+ L L+ +++K+Q L K + S + ++K++ Q
Sbjct: 457 DAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL-KNKSVTQ 515
Query: 858 LKPRSPDHVL-----------KNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVI 906
D+ K+T + Q +T E V + T+ +++
Sbjct: 516 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETV---TTVTTREQIL 572
Query: 907 SPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKD 966
E + P PP K I + S + + +L V+ L SW + +
Sbjct: 573 VKHAQEELPPP-----PPQKKRQITVDSEIRK----------RLDVDITELHSW--ITRS 615
Query: 967 LDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLR-LEEEVEAC 1025
++Q+ R + ++ D L++ +++ A++ R L++ +
Sbjct: 616 EAVLQSPEFAIFRK-------------EGNFSD-LKEKVNAIEREKAEKFRKLQDASRSA 661
Query: 1026 KARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ 1085
+A + ++ N D +I+ E+ R ++ Q L S R + +Q
Sbjct: 662 QALVEQMVNEGVNAD--------------SIKQASEQLNSRWIEFCQ-LLSERLNWLEYQ 706
Query: 1086 DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPT-LRSELNLLVEKMDH 1144
+N + Q LQQL + ++ +++L P++ S PT ++S+L + ++++
Sbjct: 707 NNIIAFYNQ------LQQL----EQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNR 756
Query: 1145 VYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQE-EVVLADLSALEAHWSTL--- 1200
+ GL + +LK + ++ + + + + + V +D+ A E T+
Sbjct: 757 LSGLQP-QIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDT 815
Query: 1201 -------------RHWLSDVKDKNSV--FSVLDEEIAKAKV------------------- 1226
R W+ + K S+ SV D EI + ++
Sbjct: 816 LPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYY 875
Query: 1227 ---VAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRAC 1283
++MS+ P +YQ + +++ RW ++ +QL +LE L +
Sbjct: 876 LSTTVKEMSKKAPSEIS--RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 933
Query: 1284 HGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQY 1343
TL KW+ E + P DS +L +QL Q L ++I+ Q L+ + Q+
Sbjct: 934 IQTLKKWMAEVDVFLKEEWPALG-DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 992
Query: 1344 STIVK-DYELQLMTYKAFVESQ-----QKSPGKRRRMLSSSDAITQEFMDLRTRYTALVT 1397
+ ++ +L T + +Q Q+ ++ + + DL + +
Sbjct: 993 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1052
Query: 1398 LTTQHVK-----YISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS 1452
++++ D L++ EE K +EE Q+ KVK L V+++ A +
Sbjct: 1053 AEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1112
Query: 1453 ETKESTDIEKAILEQQVLSEELTTKKEQVSEA----------IKTSQIFLAKHGHKLSEK 1502
KE +E Q L L K + + E ++ + +L + KL
Sbjct: 1113 LKKE---LETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTT 1169
Query: 1503 EK-----KQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE 1557
E ++ISE L++L + + NQ++ L L T+ + + N ++LE
Sbjct: 1170 ENIPGGAEEISEVLDSLENLMRH-SEDNPNQIRILAQTL---TDGGVMDELIN---EELE 1222
Query: 1558 DLCS-WVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKD---- 1612
S W E A+ + + +Q + + Q+ + L +Q+ + A + D
Sbjct: 1223 TFNSRWRELHEEAV--RRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1280
Query: 1613 --IEGFMEENQTKLSPRELTALREKLH-QAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
+ ++ Q+ L+ E++ K H Q KE + + + VAQK+L++ V+ +
Sbjct: 1281 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQD-VSMKFRLFQ 1339
Query: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGY- 1728
+ + + L E+K +D ++ +LP +E S+E+ + + +
Sbjct: 1340 KPANFEQRLQESKMILD--------------EVKMHLPALET---KSVEQEVVQSQLNHC 1382
Query: 1729 MGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQK 1788
+ + ++ ++ + EM+ ++++ ++Q E + L ++
Sbjct: 1383 VNLYKSLSEVKSEVEMVIKTGRQIVQKKQT---------------------ENPKELDER 1421
Query: 1789 LGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSP 1848
+ LK Y+ A+ +Q++ +K ++ WL ++ EL P
Sbjct: 1422 VTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMP 1481
Query: 1849 ETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKD 1908
L S + + +++ K L+ +T G+ + + GK+ + LV+DKL
Sbjct: 1482 SNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV-----LGKKET----LVEDKLSL 1532
Query: 1909 ATERYTALHSKCTRLGSHLNMLLG-QYHQ--FQNSADSLQAWMQACEANVEKLLSDTVAS 1965
+ A+ S R LN+LL Q H F + D + W+ + LL ++
Sbjct: 1533 LNSNWIAVTS---RAEEWLNLLLEYQKHMETFDQNVDHITKWI----IQADTLLDESEKK 1585
Query: 1966 DPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDH-RHVQETTDSILS 2024
P Q++ K+L+ EL + + V+ + A ++M G DH R + E S L+
Sbjct: 1586 KP---QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELN 1638
Query: 2025 H-FQSLSYSL-AERSSLLQKAIAQ----SQSVQESLESLLQSIGEVEQNLEGKQVSSLSS 2078
H F ++S+ + ++S+ K + Q Q + E LE+ +Q +++ K ++ +
Sbjct: 1639 HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1698
Query: 2079 GVIQEALATNMKLKQDIARQKSSLE-ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQ 2137
G ++E L L+Q I ++ E ++ + + A + + K E+S ++ Q
Sbjct: 1699 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1758
Query: 2138 LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQEL 2197
++ + L + +++ + LAS +P + ++I+E+
Sbjct: 1759 ---------------------YKRQADDLLKCLDDIEKKLASLPEPRDE-----RKIKEI 1792
Query: 2198 NLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASS 2257
+ E++ ++E L+ + LS G A+ + + T++Q + + RE ++
Sbjct: 1793 DRELQKKKEELNAVRRQAEGLSEDGAAMAV------------EPTQIQLSKRWREIESKF 1840
Query: 2258 CQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLL---------DD 2308
Q + F + + T ++ P E S +I H+ L D
Sbjct: 1841 AQFRRLNFAQ-IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPD 1899
Query: 2309 WASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEI 2368
+K E++ + SL+N+ DS ++ + + S + T + ++
Sbjct: 1900 LCAKD--FEDLFKQEESLKNI------KDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 1951
Query: 2369 QCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMS 2428
Q +S ++ ++EK+ + +RQ + + H + QWL E+ L+
Sbjct: 1952 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI-- 2009
Query: 2429 SPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL---LVTYPNSQEAENWKKIQE 2485
P E K K +L EL+ + Q V L ++ + +A ++
Sbjct: 2010 -PENWEHAK-----YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2063
Query: 2486 ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPN 2544
LN RW+ + R+++LEE + L+ FQ ++ WL E + + + PL
Sbjct: 2064 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEPGKEQ 2121
Query: 2545 MLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE 2604
L + +QV+ +++E R+ +QLNE +L +++ +L+ N +W++
Sbjct: 2122 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIK 2181
Query: 2605 LTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV---QSAISTQPE------ 2655
++ L + +I+ I Q ++ L+DL E++ + LS Q I QP
Sbjct: 2182 VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD 2241
Query: 2656 ------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRL---- 2705
AV+ + + EI S + L E Q + +L L E + L + L
Sbjct: 2242 VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQ 2301
Query: 2706 ---------------ETVALPLQGL--EDLAADRI---NRLQAALASTQQFQQMFDELRT 2745
+TV L Q + ++ A ++ + L + + F + + EL
Sbjct: 2302 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2361
Query: 2746 WLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPG 2805
WL + LE + + + + + L Q E ++ ++L
Sbjct: 2362 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2421
Query: 2806 EEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMS 2865
E + + +++ ++N W+E+ + +R+ +L + ++ + ++ E+ + +AK+
Sbjct: 2422 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 2481
Query: 2866 ELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED-GIRDE 2921
+ T+D +Q + +K + ++ + ++ +++ N A L+ AD+ +
Sbjct: 2482 SWKEGPYTVDAIQ--KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 2539
Query: 2922 KAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ---ESFKNIEKKVEGAKHQLEIFDALG 2978
IN + ++ + + + +LEE + L++F E F + E + L+
Sbjct: 2540 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2599
Query: 2979 SQACSNKNLEKLRAQQEVLQA-LEPQVDYLRNF---TQGLVEDAPDGSDASQLLHQAEVA 3034
+K +++L Q + LQ +E D N +Q ++ DA L + +
Sbjct: 2600 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2659
Query: 3035 QQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQ 3094
++ E++++ + +E + + H ++E+ L DDEL IG D ++Q
Sbjct: 2660 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ 2719
Query: 3095 SQ---------------------IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDL 3133
Q +E VR+FL + + L E E R + EE ++
Sbjct: 2720 KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL--EKLYQEPRELPPEERAQNV 2777
Query: 3134 LG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQ 3192
L+++ E +N + KL Q +++ TL R+++ L+ AE +
Sbjct: 2778 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2837
Query: 3193 WVVG-TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3251
VG ++ + L K + E + PL+ + VN L + L + G L +
Sbjct: 2838 QPVGDLLIDSLQDHLEKVKALRGE-IAPLKENVSHVNDLARQL-TTLGIQLSPYNLS-TL 2894
Query: 3252 EEINARWNTLNKKVAQRIAQLQEA 3275
E++N RW L V R+ QL EA
Sbjct: 2895 EDLNTRWKLLQVAVEDRVRQLHEA 2918
Score = 238 bits (606), Expect = 2e-61
Identities = 494/2777 (17%), Positives = 1066/2777 (38%), Gaps = 367/2777 (13%)
Query: 1431 VKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI 1490
++E+L W+ + Q + S E + E ++ +LT + +V ++
Sbjct: 225 LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMM--DLTAHQGRVGNILQLGSK 282
Query: 1491 FLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQN 1550
+ KLSE E+ ++ EQ+N LN + L S + L + L QN
Sbjct: 283 LIGTG--KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL---------HRVLMDLQN 331
Query: 1551 TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRAT 1604
Q+L++L W+ + E + DL L++ K LQ+D++ N T
Sbjct: 332 ---QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 388
Query: 1605 SFATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVA 1653
VV + G +EE L R R L +++ L EE +
Sbjct: 389 HMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLF 448
Query: 1654 QKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLS 1713
L E + + T K E+ + +K+ L + S G+L + + L
Sbjct: 449 SAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL---KQDLL 505
Query: 1714 GASLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ 1772
K T+ ++ + + L ++ E A+ + ++ Q + T +
Sbjct: 506 STLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT-- 563
Query: 1773 HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ-DHKEFESWL 1831
+T EQ +++ E L + K+ T+ E++K L D E SW+
Sbjct: 564 ---TVTTREQILVKHAQEE--------LPPPPPQKKRQITVDSEIRKRLDVDITELHSWI 612
Query: 1832 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 1891
RSE L+ SPE ++ +++G+FS+ R +K+ D S +
Sbjct: 613 TRSEAVLQ-------SPEF--AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 663
Query: 1892 GKEPSEIGNLVKDKLKDATERYTALHSK-CTRLGSHLNMLLGQYH--QFQNSADSLQAWM 1948
E + D +K A+E+ + + C L LN L Q + F N L+
Sbjct: 664 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMT 723
Query: 1949 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2008
E ++ + T S+P ++ QL K L+ Q +E+L K+ ++ +G+
Sbjct: 724 TTAENWLK--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERL-KIQSIALKEKGQ- 779
Query: 2009 APDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI--AQSQSVQESLESLLQSIGEVEQ 2066
+ + +HF+ + + R LQ QE++ ++ + + E
Sbjct: 780 --GPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 837
Query: 2067 NLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQG 2126
L Q+S ++++ L L+ + Q+S L V + A S + Q
Sbjct: 838 KLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQS 897
Query: 2127 KLAEVSQRFEQL-------CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS 2179
+ E+ R+++L C + +E+ + L+K+ + + ++ F++ + L
Sbjct: 898 EFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD 957
Query: 2180 GNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRK 2239
+ + +Q + L +++ Q +L+++ ++ + + + ++ L
Sbjct: 958 ----SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNT 1013
Query: 2240 DFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQ 2298
+ + + V R++ E+ +K + +W+ + E + + EL+K
Sbjct: 1014 QWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA 1073
Query: 2299 IEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNG 2358
+E +K ++ K V+ + T N ++ P +Q
Sbjct: 1074 VEEMKRAKEEAQQKEAKVKLL----TESVNSVIAQAPPVAQ------------------- 1110
Query: 2359 YHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKE 2418
++ ++ + Y+ L L+ + ++L+ + E+ +WL E
Sbjct: 1111 -------EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE 1163
Query: 2419 EVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQE 2476
LK+ + + P E + +S + + E N +I+ + + L G++ N +
Sbjct: 1164 FKLKTTE--NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEE- 1220
Query: 2477 AENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVL 2536
E NSRW E V RQ+ LE+S + + ++ L + +
Sbjct: 1221 -------LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1273
Query: 2537 GPLSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQK 2593
+D + + Q++Q L E ++H Q EAAQ +L+ QK
Sbjct: 1274 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLS-------QIDVAQK 1326
Query: 2594 ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQ 2653
+LQ ++ K+ + K +++ LQ+ + V L S +
Sbjct: 1327 KLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE 1371
Query: 2654 PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK-------DELKKRLE 2706
E V+ QL + L ++ EV E+ + G Q ++ EL +R+
Sbjct: 1372 QEVVQSQLNHCVNLYKSLSEVKSEV--------EMVIKTGRQIVQKKQTENPKELDERVT 1423
Query: 2707 TVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER 2766
+ L L +R +L+ L +++ ++ + L WL + K +
Sbjct: 1424 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1483
Query: 2767 LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS 2826
L S++ + QK + + + I GE+L + G+++ ++++L L ++W ++
Sbjct: 1484 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL--GKKETLVEDKLSLLNSNWIAVT 1541
Query: 2827 KKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM 2886
+ + + L + + + + +V+ + WI + E P Q E L R KA
Sbjct: 1542 SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAE 1600
Query: 2887 LNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS--LE 2944
LN++ R + + AA+++ N + + + + +N A++ ++ S L+
Sbjct: 1601 LNDI--RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLK 1658
Query: 2945 EMTQRLREFQESFKNIEKKVE--------------------GAKHQLEIFDALGSQACSN 2984
E+ Q + Q+ + +E +++ K L+ D L +
Sbjct: 1659 ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDE 1718
Query: 2985 KNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQR 3044
+ E+++ +Q++LQ + LR+ + A ++ HQ +++ ++ +
Sbjct: 1719 RKREEIKIKQQLLQTKHNALKDLRSQRR---------KKALEISHQWYQYKRQADDLLKC 1769
Query: 3045 VNSGCVMMENKLEGIGQ--FHCRVREMFSQLADLDDELDGM--GAIGRDTDSLQSQIEDV 3100
++ +E KL + + +++E+ +L +EL+ + A G D +E
Sbjct: 1770 LDD----IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPT 1825
Query: 3101 RLFLNK-------------------IHVLK----------LDIEASE------AECRH-- 3123
++ L+K IH ++ + +E S E H
Sbjct: 1826 QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVS 1885
Query: 3124 --MLEEEGTLDLLGL-KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND 3180
+LE E L+ L ++ E L KQ E K ++ L+ + GR++ + K
Sbjct: 1886 QALLEVEQLLNAPDLCAKDFEDLFKQ----EESLKNIKDSLQQSSGRIDIIHSKKTAALQ 1941
Query: 3181 ATTAAEEA---EAL-----QWV----------------------VGTEVEIINQQLADFK 3210
+ T E EAL QW +++I NQ L + +
Sbjct: 1942 SATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE 2001
Query: 3211 MFQKEQVDP---------------------LQMKLQQVNGLGQGLIQSAGKDCDVQGLEH 3249
F ++ P Q ++ +N G+ +IQ + K D L+
Sbjct: 2002 QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK-TDASILQE 2060
Query: 3250 DMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAE 3309
+ +N RW + K+++ R +L+E +FQ L + WL + + + + P E
Sbjct: 2061 KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE 2120
Query: 3310 YKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA--DREKITGQLESLESRW 3367
+ +K ++++ KLL L R+ + L GG + SA ++ +++K+ +L+ +W
Sbjct: 2121 QQ-LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQW 2179
Query: 3368 TE----LLSKAAARQKQLEDILVLAKQFHETAEPISDFL----SVTEKKLANSEPVGTQT 3419
+ L K + Q++D+ L K+ + E ++ L + + ++P
Sbjct: 2180 IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP 2239
Query: 3420 AKIQQQIIRHKALEEDIENHATDVHQAVK-------IGQSLSSLTSP------------A 3460
+Q+ I +A + D+E + K + + L L+S A
Sbjct: 2240 FDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRA 2299
Query: 3461 EQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL-------------FGEDEVEV 3507
+Q L+ + ++ A ++ + + A+S + F E+
Sbjct: 2300 KQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTEL 2359
Query: 3508 LNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTT 3567
+WL+ ++ + S V + ++ A +++ R+ +++ I Q L +T+
Sbjct: 2360 TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTS 2419
Query: 3568 GEEV-LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEE 3626
+E +I ++++ I+ ++ ++ + L + + +T++ EE L + +
Sbjct: 2420 NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAK 2479
Query: 3627 LATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKL 3686
L + T + I + K+L K++ + + +D N+++ LL + +
Sbjct: 2480 LESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 2539
Query: 3687 VSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR--- 3743
+ N ++ + + +R ++ + QQ+ + LAW+ E + L
Sbjct: 2540 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2599
Query: 3744 --LEQDQTTAQLQVQ-KAFSIDIIRHKDSMDELFSHRSEIFGTC-GEEQKTVLQEKTESL 3799
LE + +L Q + +I H D L + +I + G + +LQ + +++
Sbjct: 2600 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2659
Query: 3800 IQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLR 3859
++ + + + LE + + + +EL W++ +++ D ++
Sbjct: 2660 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ 2719
Query: 3860 QQQEEMRQLRESIAEHKPHIDKLLKIG---------PQLKELNPEEGEM-VEEKYQKAEN 3909
+Q + R + + +P I L+ L++L E E+ EE+ Q
Sbjct: 2720 KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTR 2779
Query: 3910 MYAQIKEEVRQRALALD-EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK 3968
+ + EEV L+ + +I E ++++ + E + L +LR +I
Sbjct: 2780 LLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQP 2839
Query: 3969 IRECISDNKSATVELEK 3985
+ + + D+ +E K
Sbjct: 2840 VGDLLIDSLQDHLEKVK 2856
Score = 196 bits (498), Expect = 5e-49
Identities = 481/2824 (17%), Positives = 1126/2824 (39%), Gaps = 356/2824 (12%)
Query: 1246 QEKGSQLQERWHRV-IAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKP 1303
QE+ + L RW + +A +E +QS L + L + + L W+ +T + ++M +
Sbjct: 298 QEQMNLLNSRWECLRVASME-KQSNLHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEE 354
Query: 1304 GQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVES 1363
D L Q+ Q L ++E+ Q +++ S + +V D
Sbjct: 355 PLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN-----SLTHMVVVVD-------------- 395
Query: 1364 QQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDAL---RRLEEEEKVV 1420
+S G ++ A+ ++ L R+ + T + D L +RL EE+ +
Sbjct: 396 --ESSGDH-----ATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLF 448
Query: 1421 E---EEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTK 1477
EK++ V K+ +T G K+ ++ ++ + VL +L K
Sbjct: 449 SAWLSEKEDAVNKI------------HTTG------FKDQNEMLSSLQKLAVLKADLEKK 490
Query: 1478 KEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA 1537
K+ + + Q L S + K ++++ A + D N +Q+L+ A
Sbjct: 491 KQSMGKLYSLKQDLL-------STLKNKSVTQKTEAWLDNFARCWD---NLVQKLEKSTA 540
Query: 1538 HQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQD 1597
Q Q Q + + + + V E+ L H Q++L + +
Sbjct: 541 -QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKH----AQEELPPPPPQKKRQITVDS 595
Query: 1598 DIQNRA----TSFATVVKDIEGFMEENQTKLSPRE--LTALREKLH----QAKEQYEALQ 1647
+I+ R T + + E ++ + + +E + L+EK++ + E++ LQ
Sbjct: 596 EIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQ 655
Query: 1648 EETRVAQKELEEAVTSALQQETEKSKAAKEL----AENKKKIDALLDWVTSVGSSGGQLL 1703
+ +R AQ +E+ V + ++ K +A+++L E + + L+W+ +
Sbjct: 656 DASRSAQALVEQMVNEGVNADSIK-QASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FY 713
Query: 1704 TNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILAT 1763
L +EQ++ + + T P + Q ++ K L Q I
Sbjct: 714 NQLQQLEQMTTTAENWLKIQPT-----TPSEPTAIKSQLKICKDEVNRLSGLQPQ-IERL 767
Query: 1764 QSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFL 1821
+ L + G L + + +A K++QT+ D L ++
Sbjct: 768 KIQSIALKEKGQG-----PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQ 822
Query: 1822 QDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQK 1881
+ +W+++SE +L + E + L + + + L +++ + ++
Sbjct: 823 ETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE 882
Query: 1882 VLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSA 1941
+ K PSEI + + ++ R+ L S+ L + + + QN
Sbjct: 883 M--------SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHI 934
Query: 1942 DSLQAWMQACEANVEKLLSDT--VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 1999
+L+ WM A V+ L + D +L++QL KQ + +++ Q L V
Sbjct: 935 QTLKKWM----AEVDVFLKEEWPALGDSEILKKQL---KQCRLLVSDIQTIQPSLNSVNE 987
Query: 2000 DIMEIEGEPAPDHRHVQETT-DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2058
+I+ E P+ ET + + + + + R L+ + ++ S+Q+ L +
Sbjct: 988 GGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMH 1047
Query: 2059 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2118
+ + + E+ + + +Q+A+ + K++ ++++ ++ E V + A
Sbjct: 1048 EWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP 1107
Query: 2119 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQFMENKSRML 2177
L+ +L ++ ++ LC + K +L+++ E+ +L + E + ++
Sbjct: 1108 VAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLK 1167
Query: 2178 ASGNQPD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQ 2235
+ N P ++I+ ++ L ED + L +T+ G +D +++ ++
Sbjct: 1168 TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD----GGVMDELINEE-LE 1222
Query: 2236 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL 2295
+ EL + R+K L+ + +ETE S+ + S++ +
Sbjct: 1223 TFNSRWRELHEEAVRRQK--------------LLEQSIQSAQETEKSLHLIQESLTF--I 1266
Query: 2296 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2355
+KQ+ + D A ++I TS E + +E +QGK +
Sbjct: 1267 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHE-ISLEEMKKHNQGKEAA----------- 1314
Query: 2356 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2415
+ Q + DV++K+ L ++ + + L + + E L LE
Sbjct: 1315 ---QRVLSQIDVAQKKLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPALE 1366
Query: 2416 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2475
+K + E V++Q L + +++ V + ++ +
Sbjct: 1367 TKS------------VEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV----QKK 1410
Query: 2476 EAENWKKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELM 2532
+ EN K++ E + + E+ R++QLE+ + + L WL ++
Sbjct: 1411 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1470
Query: 2533 MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ 2592
+ + P+ L+++ + KE E ++ + + E + + T G + V+
Sbjct: 1471 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK---KETLVE 1527
Query: 2593 KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAIST 2652
+L +N W+ +T S+ ++ + +YQ+ ++ + V + + + +
Sbjct: 1528 DKLSLLNSNWIAVT-------SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1580
Query: 2653 QPEAVKQQLEET--SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVAL 2710
+ E K Q +E ++++L + +V + L G D +K +E
Sbjct: 1581 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-----DHCRKLVEPQIS 1635
Query: 2711 PLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 2770
L + RI +A++ ++ +Q +++ L+ P+ A+++ Q
Sbjct: 1636 ELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLE----------PLEAEIQ--QGV 1682
Query: 2771 LQENEEFQKSLNQ-HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKT 2829
+ E+F K +N+ + G+ + ++ G++L + ++ ++ + L+ L
Sbjct: 1683 NLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLR 1742
Query: 2830 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAM 2886
+ R+ + + + +Y+ +DL+ ++D + K++ L D +++ L + K
Sbjct: 1743 SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEE 1802
Query: 2887 LNEVEKRRSLLEILNSAADILINSSEADEDG--IRDEKAGINQNMDAVTEELQAKTGSL- 2943
LN V ++ L +A + + + I + A + A ++ +T +
Sbjct: 1803 LNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVM 1862
Query: 2944 -EEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
E+M + ++ V A LE+ L + K+ E L Q+E L+ ++
Sbjct: 1863 TEDMPLEISYVPSTYLTEITHVSQAL--LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 1920
Query: 3003 -------QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--EVKQRVNSGCVMME 3053
++D + + ++ A + ++ Q ++Q +F +V + +
Sbjct: 1921 SLQQSSGRIDIIHSKKTAALQSA---TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 1977
Query: 3054 NKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ--IEDVRLFLNKIHVLK 3111
+E +FH ++ +F+Q ++ I + + + + +++++ + + +
Sbjct: 1978 RSVEKWRRFHYDIK-IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVV 2036
Query: 3112 LDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQ----CGKLTERGKARQEQLELTLGR 3167
+ A+ E ++++ D L+ +L +LN + C +L++R K +EQ +
Sbjct: 2037 RTLNATGEE---IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI---- 2089
Query: 3168 VEDFYRKLKGLNDATTAAEEAEALQWVV---GTEVEIINQQLADFKMFQKEQVDPLQMK- 3223
+ +F R L N+ EEA+ + + G E ++ ++L K+ +E PL+
Sbjct: 2090 LSEFQRDL---NEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL--PLRQGI 2143
Query: 3224 LQQVNGLGQGLIQSAGKDCDVQG-LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF 3282
L+Q+N G ++ SA + Q LE+ +++ N +W +++ + ++ +++ + G+
Sbjct: 2144 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2203
Query: 3283 QDALEPL-------LSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVD 3335
+ LE L L WL+ + P+ E +QE ++ + ++ V+
Sbjct: 2204 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF---DVQETEIA---VQAKQPDVE 2257
Query: 3336 MLQAEGGRIAQSAELADREKITGQLESLESRW---TELLSKAAARQKQLEDIL------- 3385
+ ++G + + E + + +LE L S W LL + A+Q L L
Sbjct: 2258 EILSKGQHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 2315
Query: 3386 ----------VLAKQ---------------------FHETAEPISDFLSVTEKKLANSEP 3414
V+ K+ F+ ++D+LS+ ++ + +
Sbjct: 2316 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2375
Query: 3415 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQ 3473
+ I + II+ KA +D+E + + + Q+L + TS E + +++++I+ +Q
Sbjct: 2376 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2435
Query: 3474 ARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHR 3533
++ E+Q+ + L++ L ++ + E + E L + KL S + D + +
Sbjct: 2436 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2495
Query: 3534 QHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSS 3593
+ + L +++ + NVD A LL+ + ++ + + I + I S
Sbjct: 2496 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2555
Query: 3594 KALRTLEQARQLATKFQSTYEELTGWLREVE------EELATSGGQSPTGEQIPQFQQRQ 3647
+ LE+ +L +F E+ WL E E ++ + + + ++
Sbjct: 2556 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 2615
Query: 3648 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLV------SDANEQYKLVSDTI 3701
++L+ E+ H V ++E S+ +L R+ EG D V + N ++ +
Sbjct: 2616 QDLQGEIEAHTDVYHNLDENSQKIL-----RSLEGSDDAVLLQRRLDNMNFKWSELRKKS 2670
Query: 3702 GQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF-- 3759
++A+ + ++ + L W+ +L PI + Q V +AF
Sbjct: 2671 LNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKR 2730
Query: 3760 -----------SIDIIR------HKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQ 3801
+++ +R + +++L+ E+ + T +L+++ E +
Sbjct: 2731 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNT 2790
Query: 3802 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQ 3860
++E ++L +++ +++ + + E +EL + + + P + + L+
Sbjct: 2791 EWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQD 2850
Query: 3861 QQEEMRQLRESIAEHKPHIDKLLKIGPQLK----ELNPEEGEMVEEKYQKAENMYAQIKE 3916
E+++ LR IA K ++ + + QL +L+P +E+ + + + +++
Sbjct: 2851 HLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVED 2910
Query: 3917 EVRQ 3920
VRQ
Sbjct: 2911 RVRQ 2914
Score = 184 bits (467), Expect = 2e-45
Identities = 361/1991 (18%), Positives = 773/1991 (38%), Gaps = 283/1991 (14%)
Query: 3270 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDD 3329
+ L E+ ++ ++Q ALE +LSWL E+ + Q S + +VVK Q + L
Sbjct: 209 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 268
Query: 3330 RKATVDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTELLSKAAARQKQLEDILVL 3387
+ V + G ++ + +L++ E+ + Q+ L SRW L + A+ +KQ VL
Sbjct: 269 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL--RVASMEKQSNLHRVL 326
Query: 3388 AKQFHETAEPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3445
++ + ++D+L+ TE++ EP+G +++Q+ +HK L+ED+E V+
Sbjct: 327 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 386
Query: 3446 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 3505
+ + + L E++ L R++ I + LL L + E++
Sbjct: 387 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQC 446
Query: 3506 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA-LNEEIVNRKKNVDQAIKNGQALLK 3564
WL+E ED ++ + FK LA L ++ +K+++ + Q LL
Sbjct: 447 LFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLS 506
Query: 3565 QTTGEEVLLIQEKL--------DGIKTRYADITVTSSKALRTLEQARQLATKFQS----- 3611
+ V E D + + T S+A+ T + + T ++
Sbjct: 507 TLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 566
Query: 3612 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVME-HRLVLDTVNEVSRA 3670
T E++ ++ +EEL Q QI + +K L ++ E H + T +E
Sbjct: 567 TREQIL--VKHAQEELPPPPPQKK--RQITVDSEIRKRLDVDITELHSWI--TRSEAVLQ 620
Query: 3671 LLELVPWRAREGLDKLVSDAN-------EQYKLVSDT-------IGQRVDE---IDAAIQ 3713
E +R L N E+++ + D + Q V+E D+ Q
Sbjct: 621 SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQ 680
Query: 3714 RSQQYE-------QAADAELAWVAETKRKLMALGPIR-LEQDQTTAQ--LQVQK------ 3757
S+Q Q L W+ + ++ LEQ TTA+ L++Q
Sbjct: 681 ASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP 740
Query: 3758 -AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES-LIQQYEAISLLN----- 3810
A + KD ++ L + +I + Q L+EK + + + ++ N
Sbjct: 741 TAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQV 798
Query: 3811 -SERYARLERAQVLVN-----QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 3864
S+ AR + Q + + ++ ET + W++++ ++ D+E + Q+ E
Sbjct: 799 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 858
Query: 3865 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALA 3924
++ L+ S+ E + L + +KE++ + + KYQ EE+ R
Sbjct: 859 LQALQSSLQEQQ---SGLYYLSTTVKEMSKKAPSEISRKYQSEF-------EEIEGRWKK 908
Query: 3925 LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK--------------IR 3970
L S+Q+ E K+E + L + + ++ AEVD ++
Sbjct: 909 L------SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 962
Query: 3971 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4030
+ + + +++ +QPS ++ G+++ A+ + A++ ++ +L ++ W+ +
Sbjct: 963 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKI---KNEAEPEFASR-LETELKELNTQWDHM 1018
Query: 4031 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4090
+ R+ LE D++ + + ++ + + P +++ VE +
Sbjct: 1019 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1078
Query: 4091 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4150
KEE +++ + +I + ++K ++ + ++ L + + L
Sbjct: 1079 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1138
Query: 4151 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MPPVGTDLNTVKDQL-NEMKEFKVEVY 4206
E+ + L+ WL+ KL T +P +++ V D L N M+ +
Sbjct: 1139 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1198
Query: 4207 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4266
Q +I + L G + ++I E L W L E+ RQ LE ++ +
Sbjct: 1199 QIRILAQTLTDGGVM----------DELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1248
Query: 4267 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326
+ + +L + LT ++ L A D + E K +++D+ +H+ ++E +
Sbjct: 1249 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMK 1305
Query: 4327 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4386
K + + A + S+++ + + V K Q+ F +++
Sbjct: 1306 K------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQKPANFEQRLQES 1351
Query: 4387 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4446
+ L ++ L A + E + QL+ + LY L + ++ GR ++ +
Sbjct: 1352 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR-QIVQKK 1410
Query: 4447 DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQS 4506
+ + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + + + WL +
Sbjct: 1411 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1470
Query: 4507 LNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 4566
L S + + + S++ K E+ + + + + G LK + K++ L+++
Sbjct: 1471 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-LVEDK 1529
Query: 4567 LVSVQSRWEKVVQRS----------------------------IERGRSLDDA-RKRAKQ 4597
L + S W V R+ I+ LD++ +K+ +Q
Sbjct: 1530 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1589
Query: 4598 FHEAWKKLIDWLEDAESHLDSELE-----ISNDPD------------------------- 4627
+ K+L L D +DS + ++N D
Sbjct: 1590 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1649
Query: 4628 --KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 4685
K + L + ++F + + I+ G LKE+ + ++ + + E+ + D
Sbjct: 1650 TGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGD 1709
Query: 4686 TVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLYKVEPQLAEDQP 4731
+ + + + + E + L S + AL+ W Y+ + Q +
Sbjct: 1710 NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-YQYKRQADDLLK 1768
Query: 4732 VHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 4785
D++ + + D K+ +EL K+ + ++R L E+ V+
Sbjct: 1769 CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--AMAVEPTQ 1826
Query: 4786 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTE 4845
+LS RW + + ++ RL A Q R+ M++ E + L + T
Sbjct: 1827 IQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 1883
Query: 4846 ALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 4893
Q+L++ + E + K EE ++ ++ + + H ++
Sbjct: 1884 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 1943
Query: 4894 ITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEELLAWIQWAETT 4942
+ R + +E L+ W K Q R + ++ + ++ W+ AE
Sbjct: 1944 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2003
Query: 4943 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKS 5002
L + IP+N + K ++ +++E+ V +T
Sbjct: 2004 LRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN--------------- 2040
Query: 5003 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5062
+ G + + Q + IL + ++ L+ RWQ+V +R+++L + + L E
Sbjct: 2041 -ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEF 2093
Query: 5063 KEFANFDFDVW 5073
+ N +F +W
Sbjct: 2094 QRDLN-EFVLW 2103
Score = 92.8 bits (229), Expect = 8e-18
Identities = 47/105 (44%), Positives = 67/105 (63%), Gaps = 3/105 (2%)
Query: 198 EKLLL-WTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQI-QSNRENL 255
EK+LL W ++ T Y + NF++ WSDG NALIH +RPDL D V QS + L
Sbjct: 14 EKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRL 73
Query: 256 EQAFEVAE-RLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPK 299
E AF +A +LG+ +LLD EDVD PD+KS++ Y++S++ P+
Sbjct: 74 EHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 118
Score = 91.3 bits (225), Expect = 2e-17
Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 31/555 (5%)
Query: 4585 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 4644
G SL ++ ++ A ++++ WL AE L ++ EISND + +K Q H+ + L
Sbjct: 208 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 267
Query: 4645 GKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 4703
Q ++ G L L ED + ++ + + +W+ + S+E+Q L L+
Sbjct: 268 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 327
Query: 4704 FSGQFMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 4761
L+ L DWL K E + E++P+ DL+ + + HKV Q++L + V
Sbjct: 328 DLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 385
Query: 4762 VLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 4820
L + E+S D T ++ QL+ L RW +C+ + + L+ L + + +
Sbjct: 386 SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 445
Query: 4821 HMLLEWLSEAEQTLR--FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVI 4878
+ WLSE E + D E L SL +E+K+ + ++ + +
Sbjct: 446 CLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL-QKLAVLKADLEKKKQSMGKLYSLKQDL 504
Query: 4879 LAVCHPDCIT-TIKHWITIIRARFEEVLTWAKQHQQRLETAL--SELVANAELLEELLAW 4935
L+ +T + W+ ++ ++ ++ ++ A+ ++ + E +
Sbjct: 505 LSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 564
Query: 4936 IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIE 4992
+ E L++ QE +P + K Q ++ RK+ DVD +T+ + R
Sbjct: 565 VTTREQILVKHAQEELPPPPPQKK-----RQITVDSEIRKRLDVD-ITELHSWITRSEAV 618
Query: 4993 PTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKL 5052
F + G L + + + + +A+ R Q ++R Q + + +
Sbjct: 619 LQSPEFAIFRKEGNFSDLKE----KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 674
Query: 5053 NDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5112
D++ + E +F + + W+ + ++ ++ F+ ++ + + T + ++
Sbjct: 675 ADSIKQASEQLNSRWIEFCQLLSERLNWLEY-QNNIIAFYNQLQQLEQMTTTAENWL--- 730
Query: 5113 LASKFPTTKLEMTAV 5127
PTT E TA+
Sbjct: 731 --KIQPTTPSEPTAI 743
>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
Length = 3685
Score = 351 bits (900), Expect = 1e-95
Identities = 526/2787 (18%), Positives = 1138/2787 (40%), Gaps = 333/2787 (11%)
Query: 2222 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2281
G+ +DL HQ RV N+ + ++L T K E + + QEQ++ + E +
Sbjct: 384 GYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQS 443
Query: 2282 SIPPTETSMSAKELEKQIEHLKSLLDDWASKG---TLVEEINCKGTSLENL--------I 2330
++ + ++L++ L+DW +K T E G LE+L +
Sbjct: 444 NLHRVLMDLQNQKLKE--------LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 495
Query: 2331 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2390
++ Q + S+ V V +G H L E + D ++ + +R
Sbjct: 496 LQEDLEQEQVRVNSLTHMV-VVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRW 551
Query: 2391 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN--KAFLA 2448
LQ IL + + + +E WL KE+ + + + E + + + KA L
Sbjct: 552 VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 611
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENW-------------------KKIQEELNS 2489
+ +Q+ K+ +K+ L L +Q+ E W +I + + +
Sbjct: 612 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 671
Query: 2490 RWERATEVTVA---------------------------RQRQLEESASHLACFQAAESQL 2522
T+ TV ++RQ+ + ++L
Sbjct: 672 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 731
Query: 2523 RPWLMEKE-LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 2581
W+ E ++ + + K++V + +E + ++ + + +AQ ++
Sbjct: 732 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 791
Query: 2582 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 2641
+ ++ +++ + +N +W+E L+ R + ++ Y +L Q L +
Sbjct: 792 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQL-QQLEQMTTTAE 850
Query: 2642 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC-DELSVLIGEQYLKDE 2700
L +Q ++P A+K QL+ +C DE++ L G Q +
Sbjct: 851 NWLKIQPTTPSEPTAIKSQLK---------------------ICKDEVNRLSGLQPQIER 889
Query: 2701 LKKRLETVALPLQGLEDLAADR-----INRLQAALASTQ----------------QFQQM 2739
LK ++++AL +G + D N + + Q ++Q+
Sbjct: 890 LK--IQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQET 947
Query: 2740 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN-QHSGSYEVIVAEGESL 2798
+RTW+ +++ + E ++ +L E + Q SL Q SG Y + E
Sbjct: 948 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE-- 1005
Query: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858
+ P E R Q++ E++ W++LS + + +L++ M K +K Q H++ L W+
Sbjct: 1006 MSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMA 1065
Query: 2859 DCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-ED 2916
+ + E L D L+ L + + ++++++ + L +N + N +E +
Sbjct: 1066 EVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS 1125
Query: 2917 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFD 2975
+ E +N D + +++ A+ +L+ ++ Q+ + + + A+ + LE
Sbjct: 1126 RLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDF 1185
Query: 2976 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3035
+ K +E+++ +E Q E +V L ++ AP + + L + E
Sbjct: 1186 EYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA-LKKELETLT 1244
Query: 3036 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3095
+ + R+N C +E E +H E+ S L + L+ + + T+++
Sbjct: 1245 TNYQWLCTRLNGKCKTLE---EVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPG 1297
Query: 3096 QIEDVRLFLNKIHVLKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTE 3152
E++ L+ + L E + + R + L + G +D L + ELE N + +L E
Sbjct: 1298 GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL-INEELETFNSRWRELHE 1356
Query: 3153 RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMF 3212
RQ+ LE ++ +A+E E ++ + I++QLA +
Sbjct: 1357 EAVRRQKLLEQSI-----------------QSAQETEKSLHLIQESLTFIDKQLA---AY 1396
Query: 3213 QKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA-- 3270
++VD QM + IQS D+ E +EE+ + K+ AQR+
Sbjct: 1397 IADKVDAAQMPQEAQK------IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQ 1443
Query: 3271 ------QLQEALLHC------GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3318
+LQ+ + F+ L+ L + + + + S E +VV++Q+
Sbjct: 1444 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1503
Query: 3319 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3378
L + L + K+ V+M+ G +I Q + + +++ ++ +L+ + EL +K R+
Sbjct: 1504 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1563
Query: 3379 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3438
+QLE L L+++ + ++++L+ T+ +L V + + ++ KA +++IE
Sbjct: 1564 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1623
Query: 3439 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 3498
+ ++G++L ++ E ++ +K+ L + + + R LL + +
Sbjct: 1624 QKVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME 1682
Query: 3499 LFGEDEVEVLNWLAEVEDKLSSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 3556
F ++ + W+ + + L K K+DVL R L E+ + + VD
Sbjct: 1683 TFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTR 1735
Query: 3557 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYE 3614
L+ L++ ++ + R+A I+ + + KA L++ Q + Q E
Sbjct: 1736 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1795
Query: 3615 ELTGWLRE---VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVN 3665
L +++ ++EE + + QR L++ + + R + +
Sbjct: 1796 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1855
Query: 3666 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQ 3720
AL +L R ++ L+ +S QYK +D + + +D+I+ + R ++ +
Sbjct: 1856 TKHNALKDLRSQRRKKALE--ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK 1913
Query: 3721 AADAELAWVAETKRKLMALGPIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHR 3777
D EL ++K L +R + + + A + V+ I + + ++ F+
Sbjct: 1914 EIDREL------QKKKEELNAVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ- 1965
Query: 3778 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 3837
F Q ++E+T ++ + + + + + + +S
Sbjct: 1966 ---FRRLNFAQIHTVREETMMVMTEDMPLEI------------SYVPSTYLTEITHVSQA 2010
Query: 3838 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEE 3896
+ E L+ A D E L +Q+E ++ +++S+ + ID + K L+ P E
Sbjct: 2011 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 2070
Query: 3897 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 3956
++E + + + ++ + + R D +V + + FH I+ + L L
Sbjct: 2071 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFL 2127
Query: 3957 RMPPLIPA--EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4014
R IP E K + + + + + + Q L GEE+I +S D +
Sbjct: 2128 RKTQ-IPENWEHAKYKWYLKELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI--- 2180
Query: 4015 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4074
+Q+KL + W+++ + +R+ + + + +F D+ + +++ +I
Sbjct: 2181 -LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE 2239
Query: 4075 PGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEM 4132
PG + + K+++E + + EE L+ + G ++ + E+ ++ + +
Sbjct: 2240 PGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2298
Query: 4133 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4192
N W +++ E+ ++E ++ Q + L+ + + L++ ++ L P+ L
Sbjct: 2299 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYN 2355
Query: 4193 DQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKK--ATDETDRDI---------IRE 4237
E ++E ++ V +Q ++E++ +G+ + K+ AT R + +
Sbjct: 2356 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNR 2415
Query: 4238 PLTELKHLWENLG-----------------------EKIAHRQHKLEGALL----ALGQF 4270
L EL+ +L ++ A + ++ +L+ AL F
Sbjct: 2416 LLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADF 2475
Query: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4330
A EL WL+ ++++ +QR + GD + I + K D+ + +E + A
Sbjct: 2476 NRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 2535
Query: 4331 ELLESSAGDDASS-LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4389
L ++ +A + + R+E + W+ V + + R QQL L+ + + E+
Sbjct: 2536 NLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQV 2595
Query: 4390 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4449
L + ++L + K + ++++ +L L+ + +T + + L LL +
Sbjct: 2596 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSAD 2654
Query: 4450 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 4509
K + W + ++ ER++ LEE L +F L++F+ WLT AE + N+
Sbjct: 2655 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV 2714
Query: 4510 ---ASPPSLILNT---VLSQIEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVL 4562
A+ +L V +++ + E+ AH D LD+ + L+ L D VL
Sbjct: 2715 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 2774
Query: 4563 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 4622
++ L ++ +W ++ ++S+ L+ + + K+ H + ++L+ WL+ + L + I
Sbjct: 2775 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPI 2834
Query: 4623 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--------------KEKTLLPE 4668
D ++ Q H+ F++ L K+PV +T+ T R + + L PE
Sbjct: 2835 GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE 2894
Query: 4669 D-SQKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 4723
+ +Q + L EV +W+ + S + Q K++E L + +A L L + E
Sbjct: 2895 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2954
Query: 4724 PQLAEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 4781
QPV GDL D + + ++ K + E+ V + R+L + +
Sbjct: 2955 VIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 3013
Query: 4782 KGQLQELSTRWDTVCKLSVSKQSRLEQ 4808
L++L+TRW L V+ + R+ Q
Sbjct: 3014 LSTLEDLNTRWKL---LQVAVEDRVRQ 3037
Score = 325 bits (833), Expect = 8e-88
Identities = 518/2775 (18%), Positives = 1115/2775 (40%), Gaps = 293/2775 (10%)
Query: 2270 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL---VEEINCKGTSL 2326
++F L E+E ++ +T+ LE+ + L S D ++G + VE + + +
Sbjct: 328 KSFGSSLMESEVNLDRYQTA-----LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 382
Query: 2327 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2386
E +M++TA QG+ G+IL +G+ G + + TE+Q M+ +N ++E L
Sbjct: 383 EGYMMDLTA--HQGRVGNILQLGSKLIGT--GKLSEDEETEVQEQMNLLNSRWECLRVAS 438
Query: 2387 HERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2446
E+Q +L +L M+ +++ + WL EE + M+ E +K Q + +K
Sbjct: 439 MEKQSNLHRVL--MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVL 496
Query: 2447 LAELEQNSPKIQK------VKEALAGLLVTYPNSQE----AENWKKIQEELNSRWERATE 2496
+LEQ ++ V + +G T ++ + W I RW +
Sbjct: 497 QEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 556
Query: 2497 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQF 2555
+ + QR EE C +A WL EKE + + D N + + Q++
Sbjct: 557 ILLKWQRLTEEQ-----CLFSA------WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV 605
Query: 2556 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 2615
+ + E ++Q +L Q +L+ + S+ T + + L + + W L KL ++Q
Sbjct: 606 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSV-TQKTEAWLDNFARCWDNLVQKLEKSTAQ 664
Query: 2616 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSV-----QSAISTQPEAVKQQLEETSEIRS- 2669
I QA+ +TQ + E V V R + Q + P K+Q+ SEIR
Sbjct: 665 ISQAVT-TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 723
Query: 2670 ---DLEQLDHEVKEAQTLCD--ELSVLIGEQYLKD-------------ELKKRLETVALP 2711
D+ +L + ++ + E ++ E D E ++L+ +
Sbjct: 724 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 783
Query: 2712 LQGL------EDLAADRINRLQAALASTQ-QFQQMFDELRTWLDDK--------QSQQAK 2756
Q L E + AD I + L S +F Q+ E WL+ + Q QQ +
Sbjct: 784 AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 843
Query: 2757 NCPISA----KLE--------RLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 2804
+A K++ ++SQL+ ++ +N+ SG I +
Sbjct: 844 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---EVNRLSGLQPQIERLKIQSIALKEK 900
Query: 2805 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA--QKYQWHVEDLVPWIEDCKA 2862
G+ L V NH++++ R+ L+ +YQ + + W++ +
Sbjct: 901 GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 960
Query: 2863 KMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-EDGIR 2919
K+S +L VT D +E L +A+ + +++++S L L++ + + ++ +
Sbjct: 961 KLSIPQLSVT-DYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1019
Query: 2920 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL-EIFDALG 2978
E I ++ +L LEE +LR+ Q + ++K + L E + ALG
Sbjct: 1020 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1079
Query: 2979 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3038
K L++ R +Q ++P ++ + Q + +A + AS+L + + ++
Sbjct: 1080 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQW 1138
Query: 3039 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3098
+ Q+V + ++ LE + EM + ++E + D LQ +E
Sbjct: 1139 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1198
Query: 3099 DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ 3158
+++ + + ++ ++ + + LK+ELE L L R +
Sbjct: 1199 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1258
Query: 3159 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3218
+ LE + L+ N E + E I++ L + + D
Sbjct: 1259 KTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSED 1318
Query: 3219 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3278
Q+ L Q L D + + ++E N+RW L+++ +R L++++
Sbjct: 1319 ----NPNQIRILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI-- 1369
Query: 3279 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQI-QEQKLLQRLLDDRKATVDML 3337
+ E L + ++ I Q KV AQ+ QE + +Q L + +++ +
Sbjct: 1370 --QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM 1427
Query: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA-- 3395
+ Q E A R +LS+ QK+L+D+ + + F + A
Sbjct: 1428 KKHN----QGKEAAQR----------------VLSQIDVAQKKLQDVSMKFRLFQKPANF 1467
Query: 3396 ----EPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3451
+ L + L E + +Q Q+ L + + ++V +K G+
Sbjct: 1468 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1527
Query: 3452 SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL 3511
+ L E++ +L+ Y+E+ + + L++ L +R ++ + WL
Sbjct: 1528 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1587
Query: 3512 AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 3571
A + +L+ + L + A A +EI +K ++ + G+AL K G++
Sbjct: 1588 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKE 1646
Query: 3572 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 3631
L+++KL + + + +T + + L L + ++ F + +T W+ + + L S
Sbjct: 1647 TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE 1706
Query: 3632 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 3691
+ P Q + K LK E+ + R +D+ + + L+ R+ ++ +S+ N
Sbjct: 1707 KKKPQ-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 1761
Query: 3692 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA 3751
++ +S I + + ++ +Q+ ++++ + E + G E+D
Sbjct: 1762 HRFAAISHRI--KTGKASIPLKELEQF----NSDIQKLLEPLEAEIQQGVNLKEEDFNKD 1815
Query: 3752 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 3811
+ + ++++ D++ + + E ++ ++ K + L ++ A+ L S
Sbjct: 1816 MNEDNEGTVKELLQRGDNLQQRITD---------ERKREEIKIKQQLLQTKHNALKDLRS 1866
Query: 3812 ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES 3871
+R + Q+ ++L +++ +A LP P D ++++ E+++ +E
Sbjct: 1867 QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEE 1925
Query: 3872 IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQ-----------IKEE--- 3917
+ + + L + G + + P + ++ +++++ E+ +AQ ++EE
Sbjct: 1926 LNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKRWREIESKFAQFRRLNFAQIHTVREETMM 1983
Query: 3918 VRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNK 3977
V + L+ + ST +TE + +LE + L++ P L + + + + K
Sbjct: 1984 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA----PDLCAKDFEDLFKQEESLK 2039
Query: 3978 SATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEER 4037
+ L++ + + + + + ++ ++Q+ L Q+ F WE + ++R
Sbjct: 2040 NIKDSLQQSSGRIDIIHSKKTAALQSATPVER----VKLQEALSQLDFQWEKVNKMYKDR 2095
Query: 4038 EIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET---IKE 4094
+ +F +E +F YD+ + + + + + P + E A+ +KE
Sbjct: 2096 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKE 2147
Query: 4095 ETDGLHEELEFIRIL---GADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE 4151
DG+ + +R L G ++I +T+ +++ + +N W+ + K +R ++LE
Sbjct: 2148 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 2207
Query: 4152 DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE 4211
+ ++Q L WL+ + ++P +K++L ++K E+ +Q
Sbjct: 2208 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 2266
Query: 4212 MEKLNHQGELMLKKAT-DETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270
+++LN G +L A ++D + L + W + + +Q ++E + LGQ
Sbjct: 2267 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2326
Query: 4271 QHALEEL-------MSWLTHTEELLDA--QRPISGDPKVIEVELAKHHVLKNDVLAHQAT 4321
+ LE+L + WL+ L+ Q G V E E+A V A Q
Sbjct: 2327 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPD 2378
Query: 4322 VETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV---LQKTEEREQQLQSTLQQAQG 4378
VE + G L + ++ +LE ++ W++V LQ+ ++ L L
Sbjct: 2379 VEEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 2436
Query: 4379 FHSEI----------EDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4428
++ ++ + M S L P A +L + L Q+ +
Sbjct: 2437 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2496
Query: 4429 -------ETYNQLLDKGRLML-------------------LSRDDSGSGSKT--EQSVAL 4460
E N+++ K + + L S ++T +
Sbjct: 2497 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 2556
Query: 4461 LEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTV 4520
++ +W V ++ R+ +L E L +T++ + +E L A L ++ +
Sbjct: 2557 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 2616
Query: 4521 LSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQR 4580
+I E K A ++ + + + +L D + + ++ + W + +R
Sbjct: 2617 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 2676
Query: 4581 SIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD------SELEISNDPDKIKLQLS 4634
ER +L++ + +QF +K + WL +AE+ + + + D +K +
Sbjct: 2677 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2736
Query: 4635 KHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
+ ++ Q + VY + + +D+ L L + KW + KS+
Sbjct: 2737 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2796
Query: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG 4754
+ LE + + +LQ L+ WL + +L+ P+ GD V D H+ F++EL
Sbjct: 2797 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 2856
Query: 4755 KRTGTV-------------------QVLKRSGRELI--ENSRDDTTWVKGQLQELSTRWD 4793
+ + + L + REL E +++ T ++ Q +E++T W+
Sbjct: 2857 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 2916
Query: 4794 TVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDT 4853
+ S Q ++++ L++ + ++ L L +AE + D LID+
Sbjct: 2917 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDS 2970
Query: 4854 HKEFMKKVEEKRVDV 4868
++ ++KV+ R ++
Sbjct: 2971 LQDHLEKVKALRGEI 2985
Score = 322 bits (826), Expect = 5e-87
Identities = 541/2849 (18%), Positives = 1142/2849 (40%), Gaps = 300/2849 (10%)
Query: 2332 EITAPDSQG--KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEK-LGGVLHE 2388
+IT +QG +T S P S + Y T D T + +K G L E
Sbjct: 277 QITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLME 336
Query: 2389 RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2448
+ +L +EEV L WL S E+ L++ +S+ E VK Q +++ ++
Sbjct: 337 SEVNLDRYQTALEEV-------LSWLLSAEDTLQAQGEISNDV--EVVKDQFHTHEGYMM 387
Query: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEE---LNSRWERATEVTVARQRQL 2505
+L + ++ + + + L+ T S++ E ++QE+ LNSRWE ++ +Q L
Sbjct: 388 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWECLRVASMEKQSNL 445
Query: 2506 EESASHLACFQAAESQLRPWLMEKELMMGVLG--PLSIDPNMLNAQKQQVQFMLKEFEAR 2563
L + E L WL + E + PL D L Q QQ + + ++ E
Sbjct: 446 HRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQE 503
Query: 2564 RQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKS 2623
+ + L + GD + T+ ++++L+ + +W + R
Sbjct: 504 QVRVNSLTHMVVVVDESSGDHA--TAALEEQLKVLGDRWANICRWTEDR----------- 550
Query: 2624 TQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 2683
LLQD+ K + + + + SA ++ E ++ T K+
Sbjct: 551 ---WVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTG------------FKDQNE 595
Query: 2684 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDEL 2743
+ L L LK +L+K+ +++ +DL + N+ + TQ+ + D
Sbjct: 596 MLSSLQKLA---VLKADLEKKKQSMGKLYSLKQDLLSTLKNK-----SVTQKTEAWLDNF 647
Query: 2744 -RTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 2802
R W + Q + IS + Q L + + ++ + +++V + L
Sbjct: 648 ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVME-TVTTVTTREQILVKHAQEEL-PP 705
Query: 2803 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKA 2862
PP ++KR + T D + R ++ + +L WI +A
Sbjct: 706 PPPQKKRQI-----------------TVDSEIR--------KRLDVDITELHSWITRSEA 740
Query: 2863 KMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL--LEILNSAADILIN---SSEADEDG 2917
+ + + S L+ K E EK L+ + +A L+ + + D
Sbjct: 741 VLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADS 800
Query: 2918 IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDAL 2977
I+ +N + L + LE + F + +E+ A++ L+I
Sbjct: 801 IKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQLEQMTTTAENWLKIQPTT 859
Query: 2978 GSQACSNKNLEKLRAQQEV--LQALEPQVDYLRNFTQGLVE--DAPDGSDASQLLHQAEV 3033
S+ + K+ K+ + EV L L+PQ++ L+ + L E P DA +
Sbjct: 860 PSEPTAIKSQLKI-CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHF 918
Query: 3034 AQQEFLEVKQRVNSGCVMMENKLEGIGQF--HCRVREMFSQLADLDDELDGMGAIGR--- 3088
+Q F +V+ R E +L+ I R +E S + + + +I +
Sbjct: 919 -KQVFSDVQAR--------EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSV 969
Query: 3089 -DTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQC 3147
D + ++ ++ +++ + + + + + M ++ + + E E + +
Sbjct: 970 TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRW 1029
Query: 3148 GKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3207
KL+ + ++LE + ++ ++ L + +W + EI+ +QL
Sbjct: 1030 KKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLK 1089
Query: 3208 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3267
++ + + +Q L VN GQ + A + LE +++E+N +W+ + ++V
Sbjct: 1090 QCRLLVSD-IQTIQPSLNSVNEGGQKIKNEAEPEF-ASRLETELKELNTQWDHMCQQVYA 1147
Query: 3268 RIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV---VKAQIQEQKLLQ 3324
R L+ L Q L + W+ EE + EYK ++ ++E K +
Sbjct: 1148 RKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLER---DFEYKTPDELQKAVEEMKRAK 1204
Query: 3325 RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDI 3384
++A V +L + A +E + +LE+L + + L ++ + K LE++
Sbjct: 1205 EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV 1264
Query: 3385 LVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3444
+ E + +L+ E KL +E + +I + + +LE + + + +
Sbjct: 1265 WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL---DSLENLMRHSEDNPN 1321
Query: 3445 QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDE 3504
Q + Q+L+ +++E++++ +R+ E+ + R+ LL+Q++ +A+ E
Sbjct: 1322 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQET-EKS 1378
Query: 3505 VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL-L 3563
+ ++ DK + ++ D Q A + ++ + + ++++ K+ Q
Sbjct: 1379 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI--QSDLTSHEISLEEMKKHNQGKEA 1436
Query: 3564 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 3623
Q ++ + Q+KL + ++ + Q F+ +E L EV
Sbjct: 1437 AQRVLSQIDVAQKKLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEV 1481
Query: 3624 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 3683
+ L +S E + L K + E + ++ V + R +++ + L
Sbjct: 1482 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1541
Query: 3684 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 3743
D+ V+ Y + + +R +++ ++ S++ + + W+A T +L +
Sbjct: 1542 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1601
Query: 3744 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 3803
+++ KA +I + K + + +E+ GE KTVL +K E+L++
Sbjct: 1602 GMPSNLDSEVAWGKATQKEIEKQKVHLKSI----TEV----GEALKTVLGKK-ETLVE-- 1650
Query: 3804 EAISLLNSERYARLERAQVLVNQFWETYEELSPW---IEETRALIAQLPSPAIDHEQLRQ 3860
+ +SLLNS A RA+ +N E + + + ++ I Q + + E+ +
Sbjct: 1651 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1710
Query: 3861 QQEE--MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGE----MVEEKYQKAENMYAQI 3914
QQ+E +++L+ + + +P +D Q L G+ +VE + + + +A I
Sbjct: 1711 QQKEDVLKRLKAELNDIRPKVDSTRD---QAANLMANRGDHCRKLVEPQISELNHRFAAI 1767
Query: 3915 KEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE-NLSSRLRMPPLIPAEVDKIRECI 3973
++ +A ++ +F+ I+ +LE LE + + + E D ++
Sbjct: 1768 SHRIKT-----GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK-----EEDFNKDMN 1817
Query: 3974 SDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKAR 4033
DN+ EL +RG+ L Q + +EI+ K + +K
Sbjct: 1818 EDNEGTVKEL----------LQRGDNL---QQRITDERKREEIKIKQQLLQTKHNALKDL 1864
Query: 4034 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIK 4093
+R K L++ ++ LL + D + + L P D IK+ + K
Sbjct: 1865 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKK 1923
Query: 4094 EETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN-----KTWKERLE 4148
EE + + + E + GA + + + + + I+ + LN +E +
Sbjct: 1924 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1983
Query: 4149 KLEDAMQAAVQYQDTL---------QAMFDWLDNTVIKLCTMPPV-GTDLNTVKDQLNEM 4198
+ + M + Y + QA+ + V +L P + D + Q +
Sbjct: 1984 VMTEDMPLEISYVPSTYLTEITHVSQALLE-----VEQLLNAPDLCAKDFEDLFKQEESL 2038
Query: 4199 KEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQH 4258
K K + Q ++ ++ + L+ AT +R ++E L++L WE + + RQ
Sbjct: 2039 KNIKDSLQQSSGRIDIIHSKKTAALQSATP-VERVKLQEALSQLDFQWEKVNKMYKDRQG 2097
Query: 4259 KLEGALLALGQFQHALEELMSWLTHTEELL-DAQRPISGDPKVIEVELAKHHVLKNDVLA 4317
+ + ++ +F + ++ WLT E+ L Q P + + + L + L++ +
Sbjct: 2098 RFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQ 2154
Query: 4318 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4377
Q V T+N G E+++ S+ DAS L+ +L ++N W+ V ++ +R+++L+
Sbjct: 2155 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2214
Query: 4378 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4437
F ++ +F+L L ++ +++ G + +E+L+ L +L ++ QL +
Sbjct: 2215 EFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNET 2273
Query: 4438 GRLMLLSRDDSGSGS-KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4496
G +L+S S K E + +W VS + E++ ++E + + + L++
Sbjct: 2274 GGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2333
Query: 4497 -------INWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 4549
+ WL+ L I + P+ ++E ++ V A + + E+ G
Sbjct: 2334 EEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQ 2387
Query: 4550 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQ------------------------------ 4579
L +K +K L + S W+ V +
Sbjct: 2388 HL--YKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2445
Query: 4580 -----------RSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 4628
+E SL F+ AW +L DWL + + S+ + D +
Sbjct: 2446 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2505
Query: 4629 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 4688
I + K K + L ++P + I + LK KT E + + + ++++WD V
Sbjct: 2506 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2565
Query: 4689 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 4748
R+ +L E L S Q+++A + L + +L + +D + + K
Sbjct: 2566 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2625
Query: 4749 FQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLE 4807
K+L + V V +L+ + S DDT V + ++ W ++ K +++ LE
Sbjct: 2626 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2685
Query: 4808 QALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTH--KEFMKKVEEKR 4865
+ + + F + L WL+EAE T L D T + L D+ KE MK+ ++ +
Sbjct: 2686 ETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2742
Query: 4866 VDVNSAVAM--------GEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 4917
++ + + +++ ++ D ++ + + ++ E+ + + LE
Sbjct: 2743 GEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA 2802
Query: 4918 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 4977
+ + L+ELL W+Q + L + Q PI + V+ H+ F E+ K+P
Sbjct: 2803 SSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEP 2860
Query: 4978 DVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP--TPPPMPILSQSEAKNPRINQLS 5035
+ +E E+ G K +P PP + + + +++
Sbjct: 2861 VI--------MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVN 2912
Query: 5036 ARWQQVWLLALERQRKLNDALDRLEELKE 5064
W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 2913 TEWEKLNLHSADWQRKIDETLERLQELQE 2941
Score = 296 bits (757), Expect = 5e-79
Identities = 510/2885 (17%), Positives = 1162/2885 (40%), Gaps = 305/2885 (10%)
Query: 1936 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 1995
++Q + + + +W+ + E ++ +++D V+++Q T + +L HQ V +
Sbjct: 343 RYQTALEEVLSWLLSAEDTLQA--QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 400
Query: 1996 KVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLE 2055
++ ++ + VQE + + S ++ L + E+ S L + + Q+ + L+
Sbjct: 401 QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN--QKLK 458
Query: 2056 SLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFM 2113
L + + E+ + L + ++ + + L++D+ +++ + + MV
Sbjct: 459 ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVD 518
Query: 2114 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQF 2169
E++ A L+ +L + R+ +C +++ L+ +L + + S L +
Sbjct: 519 ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 578
Query: 2170 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2229
+ +++ +G + ++ Q++ L ++E +++++ L L +L S + Q
Sbjct: 579 EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 638
Query: 2230 HQDR------------VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL- 2276
+ VQ L K ++ + V + S Q + E V T ++ L
Sbjct: 639 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQP--SLTQTTVMETVTTVTTREQILV 696
Query: 2277 KETEGSIPPTETSMSAK-----ELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSL 2326
K + +PP + E+ K+++ + L W ++ V + I K +
Sbjct: 697 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 756
Query: 2327 ENLIMEITAPDS---------QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNL 2377
+L ++ A + Q + S V V + K +E +N
Sbjct: 757 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE------QLNS 810
Query: 2378 KYEKLGGVLHER------QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2431
++ + +L ER Q ++ A N+++++ + + WL+ + ++P+
Sbjct: 811 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP---------TTPS 861
Query: 2432 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL---N 2488
+ +K+Q + K + L P+I+++K L ++ + + +
Sbjct: 862 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL------KEKGQGPMFLDADFVAFT 915
Query: 2489 SRWERATEVTVARQRQLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNML 2546
+ +++ AR+++L+ L +Q S +R W+ + E + + D ++
Sbjct: 916 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
Query: 2547 NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVEL 2605
+ ++Q + + ++ L+ + + P ++S + Q E + I +W +L
Sbjct: 976 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS---RKYQSEFEEIEGRWKKL 1032
Query: 2606 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 2665
+ +L ++++ + K + Q +Q L + + V L + E +K+QL++
Sbjct: 1033 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1092
Query: 2666 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELK----KRLETVALPLQGLEDLAAD 2721
+ SD++ + + SV G Q +K+E + RLET L D
Sbjct: 1093 LLVSDIQTIQPSLN---------SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1143
Query: 2722 RI----NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEF 2777
++ L+ L T Q+ E+ W+ + + + + LQ ++E +
Sbjct: 1144 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1203
Query: 2778 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 2837
++ Q +++ S++ PP ++ L+ +L L +++ L + + L+
Sbjct: 1204 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQE-ALKKELETLTTNYQWLCTRLNGKCKTLE 1262
Query: 2838 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-KAMLNEVEKRRSL 2896
+ + ++E W+ + + K+ + S +L S + ++ E +
Sbjct: 1263 EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQ 1322
Query: 2897 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 2956
+ IL A L + DE I +E N + EE + LE+ Q +E ++S
Sbjct: 1323 IRIL---AQTLTDGGVMDEL-INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1378
Query: 2957 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3016
I++ + QL + + + + + ++ + Q L + E ++ ++ QG
Sbjct: 1379 LHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-- 1434
Query: 3017 DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADL 3076
A ++L Q +VAQ++ +V + + F R++E L ++
Sbjct: 1435 -----EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANFEQRLQESKMILDEV 1481
Query: 3077 DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3136
L + + + +QSQ+ + +K ++E R +++++ T + L
Sbjct: 1482 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1541
Query: 3137 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3196
+ AL +L + R++QLE L +++ L + A + + V
Sbjct: 1542 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1601
Query: 3197 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3256
++ ++A K QKE ++ ++ L+ + +G+ L GK + +E + +N+
Sbjct: 1602 GMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKETL--VEDKLSLLNS 1658
Query: 3257 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI--ANQKPPSAEYKVVK 3314
W + + + + L E H F ++ + W+ + L+ + +K P + V+K
Sbjct: 1659 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLK 1718
Query: 3315 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL---- 3370
L+ L+D + VD + + + + R+ + Q+ L R+ +
Sbjct: 1719 R-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1771
Query: 3371 -LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI-IR 3428
KA+ K+LE F S +K L EP+ A+IQQ + ++
Sbjct: 1772 KTGKASIPLKELEQ-----------------FNSDIQKLL---EPL---EAEIQQGVNLK 1808
Query: 3429 HKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3486
+ +D+ E++ V + ++ G +L +T ++ + K LQ +++ ++D ++
Sbjct: 1809 EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQR 1868
Query: 3487 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKDFKQDVLHRQHADHL 3539
+ + ++L L ++E KL+S+ +K+ +++ ++
Sbjct: 1869 RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK----- 1923
Query: 3540 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-----KTRYADITVTSSK 3594
EE+ ++ + ++G A+ + T ++ +++ + +A I +
Sbjct: 1924 ---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1980
Query: 3595 ALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE 3649
+ + + L + STY ++ L EVE+ L + E + + ++ K
Sbjct: 1981 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 2040
Query: 3650 LKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 3709
+K + + +D ++ A L+ R L + +S + Q++ V+ R D
Sbjct: 2041 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2100
Query: 3710 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ-VQKAFSIDIIRHKD 3768
++++ +++ W+ E ++ L ++ ++ A+ + K I + +
Sbjct: 2101 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKWYLKELQDGIGQRQT 2157
Query: 3769 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 3828
+ L + EI + ++LQEK SL +++ + S+R RLE + ++++F
Sbjct: 2158 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2217
Query: 3829 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 3888
E W+EE IA +P +QL+++ E+++ L E + + + +L + G
Sbjct: 2218 RDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGP 2276
Query: 3889 L---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 3945
+ ++PEE + +E K ++ + ++ + ++ E +Q + + K+E +
Sbjct: 2277 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQIKDLGQLEKKLEDL 2333
Query: 3946 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4005
E L +L L + P+ +++ N+ ++++ + + +A + EE++ + Q
Sbjct: 2334 EEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2387
Query: 4006 GADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4064
K+ A + ++ KL+ + W+ + +E K D+A LTTI
Sbjct: 2388 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK-----------QPDLAPGLTTIG- 2435
Query: 4065 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4124
SP +++ Q V ET K E
Sbjct: 2436 --------ASPTQTVTLVTQPVVTKETA---------------------------ISKLE 2460
Query: 4125 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4184
+ S+ A + N+ W E + DWL + + +
Sbjct: 2461 MPSSLMLEVPALADFNRAWTE---------------------LTDWLSLLDQVIKSQRVM 2499
Query: 4185 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4244
DL + + + + K ++ Q++ ++E+L + + K +++ R II + + +++
Sbjct: 2500 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2559
Query: 4245 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4304
W+ + E + +R+ +L L Q+ A EE L L++ + I+ +
Sbjct: 2560 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2619
Query: 4305 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4364
+ + L D+ Q V+ N +LL + DD + E +N W S+ ++ E
Sbjct: 2620 ITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE 2679
Query: 4365 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQLDTHM 4418
RE L+ T + Q F ++E FL LT E+ + A++ L ++ +E +
Sbjct: 2680 REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQ 2739
Query: 4419 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4478
+L +++A + Y+ L + + +L S + S ++ + + KW + K +S
Sbjct: 2740 DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSH 2799
Query: 4479 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 4538
LE + + SLQE + WL L + L+ +P V Q + H+ F E+
Sbjct: 2800 LEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2859
Query: 4539 DQII-------------------ELDQTGNQLKFLSQKQDVV-LIKNLLVSVQSRWEKVV 4578
I+ +L Q +L + Q+V L++ V + WEK+
Sbjct: 2860 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2919
Query: 4579 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 4638
S + R +D+ +R ++ EA +L L AE S + D + L H E
Sbjct: 2920 LHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG---DLLIDSLQDHLE 2976
Query: 4639 FQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRDKWDTVCGKSVERQH 4696
K L G+ P+ + ++ T L + + L ++ +W + +R
Sbjct: 2977 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVR 3036
Query: 4697 KLEEA 4701
+L EA
Sbjct: 3037 QLHEA 3041
Score = 241 bits (614), Expect = 2e-62
Identities = 570/2964 (19%), Positives = 1185/2964 (39%), Gaps = 456/2964 (15%)
Query: 549 KAEPLTKATHSSSTSWFRKPMTRAELVA-------ISSSEDEGNL----RFVYELLSWVE 597
K+ T+A + +++ R P L A S E E NL + E+LSW+
Sbjct: 297 KSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLL 356
Query: 598 EMQMKLE-RAEWGNDLPSVELQLETQQHIHT----------SVEELGSSVKEARLYEGKM 646
+ L+ + E ND+ V+ Q T + ++ +LGS + + GK+
Sbjct: 357 SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKL----IGTGKL 412
Query: 647 SQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELI-----WLNEKEE 701
S++ T E + L +++ L+ S M +LH+ + + + WL + EE
Sbjct: 413 SEDEETEVQEQMNLLNSRWECLRVAS---MEKQSNLHRVLMDLQNQKLKELNDWLTKTEE 469
Query: 702 -------EELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAK 754
E L D D + + L +LE++Q SL ++ +
Sbjct: 470 RTRKMEEEPLGPDLEDLKRQVQQHK----VLQEDLEQEQVRVNSLTHMVVVVD------E 519
Query: 755 QTVEAYSAAVQSQLQWM----KQLCLCVEQH---VKENTAYFQFFSDARELES-FLRNLQ 806
+ + +AA++ QL+ + +C E +++ +Q ++ + L S +L +
Sbjct: 520 SSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKE 579
Query: 807 DSIKRKYSC---DHNTSLSRLEDL--LQDSMDEKEQ----LIQSKSSVASLVGRSKTIVQ 857
D++ + ++ D N LS L+ L L+ +++K+Q L K + S + ++K++ Q
Sbjct: 580 DAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL-KNKSVTQ 638
Query: 858 LKPRSPDHVL-----------KNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVI 906
D+ K+T + Q +T E V + T+ +++
Sbjct: 639 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETV---TTVTTREQIL 695
Query: 907 SPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKD 966
E + P PP K I + S + + +L V+ L SW + +
Sbjct: 696 VKHAQEELPPP-----PPQKKRQITVDSEIRK----------RLDVDITELHSW--ITRS 738
Query: 967 LDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLR-LEEEVEAC 1025
++Q+ R + ++ D L++ +++ A++ R L++ +
Sbjct: 739 EAVLQSPEFAIFRK-------------EGNFSD-LKEKVNAIEREKAEKFRKLQDASRSA 784
Query: 1026 KARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ 1085
+A + ++ N D +I+ E+ R ++ Q L S R + +Q
Sbjct: 785 QALVEQMVNEGVNAD--------------SIKQASEQLNSRWIEFCQ-LLSERLNWLEYQ 829
Query: 1086 DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPT-LRSELNLLVEKMDH 1144
+N + Q LQQL + ++ +++L P++ S PT ++S+L + ++++
Sbjct: 830 NNIIAFYNQ------LQQL----EQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNR 879
Query: 1145 VYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQE-EVVLADLSALEAHWSTL--- 1200
+ GL + +LK + ++ + + + + + V +D+ A E T+
Sbjct: 880 LSGLQP-QIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDT 938
Query: 1201 -------------RHWLSDVKDKNSV--FSVLDEEIAKAKV------------------- 1226
R W+ + K S+ SV D EI + ++
Sbjct: 939 LPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYY 998
Query: 1227 ---VAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRAC 1283
++MS+ P +YQ + +++ RW ++ +QL +LE L +
Sbjct: 999 LSTTVKEMSKKAPSEIS--RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1056
Query: 1284 HGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQY 1343
TL KW+ E + P DS +L +QL Q L ++I+ Q L+ + Q+
Sbjct: 1057 IQTLKKWMAEVDVFLKEEWPALG-DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1115
Query: 1344 STIVK-DYELQLMTYKAFVESQ-----QKSPGKRRRMLSSSDAITQEFMDLRTRYTALVT 1397
+ ++ +L T + +Q Q+ ++ + + DL + +
Sbjct: 1116 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175
Query: 1398 LTTQHVK-----YISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS 1452
++++ D L++ EE K +EE Q+ KVK L V+++ A +
Sbjct: 1176 AEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1235
Query: 1453 ETKESTDIEKAILEQQVLSEELTTKKEQVSEA----------IKTSQIFLAKHGHKLSEK 1502
KE +E Q L L K + + E ++ + +L + KL
Sbjct: 1236 LKKE---LETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTT 1292
Query: 1503 EK-----KQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE 1557
E ++ISE L++L + + NQ++ L L T+ + + N ++LE
Sbjct: 1293 ENIPGGAEEISEVLDSLENLMRH-SEDNPNQIRILAQTL---TDGGVMDELIN---EELE 1345
Query: 1558 DLCS-WVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKD---- 1612
S W E A+ + + +Q + + Q+ + L +Q+ + A + D
Sbjct: 1346 TFNSRWRELHEEAV--RRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1403
Query: 1613 --IEGFMEENQTKLSPRELTALREKLH-QAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
+ ++ Q+ L+ E++ K H Q KE + + + VAQK+L++ V+ +
Sbjct: 1404 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQD-VSMKFRLFQ 1462
Query: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGY- 1728
+ + + L E+K +D ++ +LP +E S+E+ + + +
Sbjct: 1463 KPANFEQRLQESKMILD--------------EVKMHLPALET---KSVEQEVVQSQLNHC 1505
Query: 1729 MGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQK 1788
+ + ++ ++ + EM+ ++++ ++Q E + L ++
Sbjct: 1506 VNLYKSLSEVKSEVEMVIKTGRQIVQKKQT---------------------ENPKELDER 1544
Query: 1789 LGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSP 1848
+ LK Y+ A+ +Q++ +K ++ WL ++ EL P
Sbjct: 1545 VTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMP 1604
Query: 1849 ETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKD 1908
L S + + +++ K L+ +T G+ + + GK+ + LV+DKL
Sbjct: 1605 SNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV-----LGKKET----LVEDKLSL 1655
Query: 1909 ATERYTALHSKCTRLGSHLNMLLG-QYHQ--FQNSADSLQAWMQACEANVEKLLSDTVAS 1965
+ A+ S R LN+LL Q H F + D + W+ + LL ++
Sbjct: 1656 LNSNWIAVTS---RAEEWLNLLLEYQKHMETFDQNVDHITKWI----IQADTLLDESEKK 1708
Query: 1966 DPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDH-RHVQETTDSILS 2024
P Q++ K+L+ EL + + V+ + A ++M G DH R + E S L+
Sbjct: 1709 KP---QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELN 1761
Query: 2025 H-FQSLSYSL-AERSSLLQKAIAQ----SQSVQESLESLLQSIGEVEQNLEGKQVSSLSS 2078
H F ++S+ + ++S+ K + Q Q + E LE+ +Q +++ K ++ +
Sbjct: 1762 HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1821
Query: 2079 GVIQEALATNMKLKQDIARQKSSLE-ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQ 2137
G ++E L L+Q I ++ E ++ + + A + + K E+S ++ Q
Sbjct: 1822 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1881
Query: 2138 LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQEL 2197
++ + L + +++ + LAS +P + ++I+E+
Sbjct: 1882 ---------------------YKRQADDLLKCLDDIEKKLASLPEPRDE-----RKIKEI 1915
Query: 2198 NLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASS 2257
+ E++ ++E L+ + LS G A+ + + T++Q + + RE ++
Sbjct: 1916 DRELQKKKEELNAVRRQAEGLSEDGAAMAV------------EPTQIQLSKRWREIESKF 1963
Query: 2258 CQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLL---------DD 2308
Q + F + + T ++ P E S +I H+ L D
Sbjct: 1964 AQFRRLNFAQ-IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPD 2022
Query: 2309 WASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEI 2368
+K E++ + SL+N+ DS ++ + + S + T + ++
Sbjct: 2023 LCAKD--FEDLFKQEESLKNI------KDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 2074
Query: 2369 QCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMS 2428
Q +S ++ ++EK+ + +RQ + + H + QWL E+ L+
Sbjct: 2075 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI-- 2132
Query: 2429 SPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL---LVTYPNSQEAENWKKIQE 2485
P E K K +L EL+ + Q V L ++ + +A ++
Sbjct: 2133 -PENWEHAK-----YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2186
Query: 2486 ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPN 2544
LN RW+ + R+++LEE + L+ FQ ++ WL E + + + PL
Sbjct: 2187 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEPGKEQ 2244
Query: 2545 MLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE 2604
L + +QV+ +++E R+ +QLNE +L +++ +L+ N +W++
Sbjct: 2245 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIK 2304
Query: 2605 LTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV---QSAISTQPE------ 2655
++ L + +I+ I Q ++ L+DL E++ + LS Q I QP
Sbjct: 2305 VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD 2364
Query: 2656 ------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRL---- 2705
AV+ + + EI S + L E Q + +L L E + L + L
Sbjct: 2365 VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQ 2424
Query: 2706 ---------------ETVALPLQGL--EDLAADRI---NRLQAALASTQQFQQMFDELRT 2745
+TV L Q + ++ A ++ + L + + F + + EL
Sbjct: 2425 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2484
Query: 2746 WLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPG 2805
WL + LE + + + + + L Q E ++ ++L
Sbjct: 2485 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2544
Query: 2806 EEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMS 2865
E + + +++ ++N W+E+ + +R+ +L + ++ + ++ E+ + +AK+
Sbjct: 2545 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 2604
Query: 2866 ELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED-GIRDE 2921
+ T+D +Q + +K + ++ + ++ +++ N A L+ AD+ +
Sbjct: 2605 SWKEGPYTVDAIQ--KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 2662
Query: 2922 KAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ---ESFKNIEKKVEGAKHQLEIFDALG 2978
IN + ++ + + + +LEE + L++F E F + E + L+
Sbjct: 2663 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2722
Query: 2979 SQACSNKNLEKLRAQQEVLQA-LEPQVDYLRNF---TQGLVEDAPDGSDASQLLHQAEVA 3034
+K +++L Q + LQ +E D N +Q ++ DA L + +
Sbjct: 2723 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2782
Query: 3035 QQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQ 3094
++ E++++ + +E + + H ++E+ L DDEL IG D ++Q
Sbjct: 2783 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ 2842
Query: 3095 SQ---------------------IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDL 3133
Q +E VR+FL + + L E E R + EE ++
Sbjct: 2843 KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL--EKLYQEPRELPPEERAQNV 2900
Query: 3134 LG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQ 3192
L+++ E +N + KL Q +++ TL R+++ L+ AE +
Sbjct: 2901 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2960
Query: 3193 WVVG-TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3251
VG ++ + L K + E + PL+ + VN L + L + G L +
Sbjct: 2961 QPVGDLLIDSLQDHLEKVKALRGE-IAPLKENVSHVNDLARQL-TTLGIQLSPYNLS-TL 3017
Query: 3252 EEINARWNTLNKKVAQRIAQLQEA 3275
E++N RW L V R+ QL EA
Sbjct: 3018 EDLNTRWKLLQVAVEDRVRQLHEA 3041
Score = 238 bits (606), Expect = 2e-61
Identities = 494/2777 (17%), Positives = 1066/2777 (38%), Gaps = 367/2777 (13%)
Query: 1431 VKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI 1490
++E+L W+ + Q + S E + E ++ +LT + +V ++
Sbjct: 348 LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMM--DLTAHQGRVGNILQLGSK 405
Query: 1491 FLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQN 1550
+ KLSE E+ ++ EQ+N LN + L S + L + L QN
Sbjct: 406 LIGTG--KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL---------HRVLMDLQN 454
Query: 1551 TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRAT 1604
Q+L++L W+ + E + DL L++ K LQ+D++ N T
Sbjct: 455 ---QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 511
Query: 1605 SFATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVA 1653
VV + G +EE L R R L +++ L EE +
Sbjct: 512 HMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLF 571
Query: 1654 QKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLS 1713
L E + + T K E+ + +K+ L + S G+L + + L
Sbjct: 572 SAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL---KQDLL 628
Query: 1714 GASLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ 1772
K T+ ++ + + L ++ E A+ + ++ Q + T +
Sbjct: 629 STLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT-- 686
Query: 1773 HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ-DHKEFESWL 1831
+T EQ +++ E L + K+ T+ E++K L D E SW+
Sbjct: 687 ---TVTTREQILVKHAQEE--------LPPPPPQKKRQITVDSEIRKRLDVDITELHSWI 735
Query: 1832 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 1891
RSE L+ SPE ++ +++G+FS+ R +K+ D S +
Sbjct: 736 TRSEAVLQ-------SPEF--AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 786
Query: 1892 GKEPSEIGNLVKDKLKDATERYTALHSK-CTRLGSHLNMLLGQYH--QFQNSADSLQAWM 1948
E + D +K A+E+ + + C L LN L Q + F N L+
Sbjct: 787 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMT 846
Query: 1949 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2008
E ++ + T S+P ++ QL K L+ Q +E+L K+ ++ +G+
Sbjct: 847 TTAENWLK--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERL-KIQSIALKEKGQ- 902
Query: 2009 APDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI--AQSQSVQESLESLLQSIGEVEQ 2066
+ + +HF+ + + R LQ QE++ ++ + + E
Sbjct: 903 --GPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 960
Query: 2067 NLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQG 2126
L Q+S ++++ L L+ + Q+S L V + A S + Q
Sbjct: 961 KLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQS 1020
Query: 2127 KLAEVSQRFEQL-------CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS 2179
+ E+ R+++L C + +E+ + L+K+ + + ++ F++ + L
Sbjct: 1021 EFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD 1080
Query: 2180 GNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRK 2239
+ + +Q + L +++ Q +L+++ ++ + + + ++ L
Sbjct: 1081 ----SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNT 1136
Query: 2240 DFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQ 2298
+ + + V R++ E+ +K + +W+ + E + + EL+K
Sbjct: 1137 QWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA 1196
Query: 2299 IEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNG 2358
+E +K ++ K V+ + T N ++ P +Q
Sbjct: 1197 VEEMKRAKEEAQQKEAKVKLL----TESVNSVIAQAPPVAQ------------------- 1233
Query: 2359 YHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKE 2418
++ ++ + Y+ L L+ + ++L+ + E+ +WL E
Sbjct: 1234 -------EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE 1286
Query: 2419 EVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQE 2476
LK+ + + P E + +S + + E N +I+ + + L G++ N +
Sbjct: 1287 FKLKTTE--NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEE- 1343
Query: 2477 AENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVL 2536
E NSRW E V RQ+ LE+S + + ++ L + +
Sbjct: 1344 -------LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1396
Query: 2537 GPLSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQK 2593
+D + + Q++Q L E ++H Q EAAQ +L+ QK
Sbjct: 1397 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLS-------QIDVAQK 1449
Query: 2594 ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQ 2653
+LQ ++ K+ + K +++ LQ+ + V L S +
Sbjct: 1450 KLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE 1494
Query: 2654 PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK-------DELKKRLE 2706
E V+ QL + L ++ EV E+ + G Q ++ EL +R+
Sbjct: 1495 QEVVQSQLNHCVNLYKSLSEVKSEV--------EMVIKTGRQIVQKKQTENPKELDERVT 1546
Query: 2707 TVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER 2766
+ L L +R +L+ L +++ ++ + L WL + K +
Sbjct: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606
Query: 2767 LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS 2826
L S++ + QK + + + I GE+L + G+++ ++++L L ++W ++
Sbjct: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL--GKKETLVEDKLSLLNSNWIAVT 1664
Query: 2827 KKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM 2886
+ + + L + + + + +V+ + WI + E P Q E L R KA
Sbjct: 1665 SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAE 1723
Query: 2887 LNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS--LE 2944
LN++ R + + AA+++ N + + + + +N A++ ++ S L+
Sbjct: 1724 LNDI--RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLK 1781
Query: 2945 EMTQRLREFQESFKNIEKKVE--------------------GAKHQLEIFDALGSQACSN 2984
E+ Q + Q+ + +E +++ K L+ D L +
Sbjct: 1782 ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDE 1841
Query: 2985 KNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQR 3044
+ E+++ +Q++LQ + LR+ + A ++ HQ +++ ++ +
Sbjct: 1842 RKREEIKIKQQLLQTKHNALKDLRSQRR---------KKALEISHQWYQYKRQADDLLKC 1892
Query: 3045 VNSGCVMMENKLEGIGQ--FHCRVREMFSQLADLDDELDGM--GAIGRDTDSLQSQIEDV 3100
++ +E KL + + +++E+ +L +EL+ + A G D +E
Sbjct: 1893 LDD----IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPT 1948
Query: 3101 RLFLNK-------------------IHVLK----------LDIEASE------AECRH-- 3123
++ L+K IH ++ + +E S E H
Sbjct: 1949 QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVS 2008
Query: 3124 --MLEEEGTLDLLGL-KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND 3180
+LE E L+ L ++ E L KQ E K ++ L+ + GR++ + K
Sbjct: 2009 QALLEVEQLLNAPDLCAKDFEDLFKQ----EESLKNIKDSLQQSSGRIDIIHSKKTAALQ 2064
Query: 3181 ATTAAEEA---EAL-----QWV----------------------VGTEVEIINQQLADFK 3210
+ T E EAL QW +++I NQ L + +
Sbjct: 2065 SATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE 2124
Query: 3211 MFQKEQVDP---------------------LQMKLQQVNGLGQGLIQSAGKDCDVQGLEH 3249
F ++ P Q ++ +N G+ +IQ + K D L+
Sbjct: 2125 QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK-TDASILQE 2183
Query: 3250 DMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAE 3309
+ +N RW + K+++ R +L+E +FQ L + WL + + + + P E
Sbjct: 2184 KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE 2243
Query: 3310 YKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA--DREKITGQLESLESRW 3367
+ +K ++++ KLL L R+ + L GG + SA ++ +++K+ +L+ +W
Sbjct: 2244 QQ-LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQW 2302
Query: 3368 TE----LLSKAAARQKQLEDILVLAKQFHETAEPISDFL----SVTEKKLANSEPVGTQT 3419
+ L K + Q++D+ L K+ + E ++ L + + ++P
Sbjct: 2303 IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP 2362
Query: 3420 AKIQQQIIRHKALEEDIENHATDVHQAVK-------IGQSLSSLTSP------------A 3460
+Q+ I +A + D+E + K + + L L+S A
Sbjct: 2363 FDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRA 2422
Query: 3461 EQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL-------------FGEDEVEV 3507
+Q L+ + ++ A ++ + + A+S + F E+
Sbjct: 2423 KQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTEL 2482
Query: 3508 LNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTT 3567
+WL+ ++ + S V + ++ A +++ R+ +++ I Q L +T+
Sbjct: 2483 TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTS 2542
Query: 3568 GEEV-LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEE 3626
+E +I ++++ I+ ++ ++ + L + + +T++ EE L + +
Sbjct: 2543 NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAK 2602
Query: 3627 LATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKL 3686
L + T + I + K+L K++ + + +D N+++ LL + +
Sbjct: 2603 LESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 2662
Query: 3687 VSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR--- 3743
+ N ++ + + +R ++ + QQ+ + LAW+ E + L
Sbjct: 2663 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2722
Query: 3744 --LEQDQTTAQLQVQ-KAFSIDIIRHKDSMDELFSHRSEIFGTC-GEEQKTVLQEKTESL 3799
LE + +L Q + +I H D L + +I + G + +LQ + +++
Sbjct: 2723 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2782
Query: 3800 IQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLR 3859
++ + + + LE + + + +EL W++ +++ D ++
Sbjct: 2783 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQ 2842
Query: 3860 QQQEEMRQLRESIAEHKPHIDKLLKIG---------PQLKELNPEEGEM-VEEKYQKAEN 3909
+Q + R + + +P I L+ L++L E E+ EE+ Q
Sbjct: 2843 KQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTR 2902
Query: 3910 MYAQIKEEVRQRALALD-EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK 3968
+ + EEV L+ + +I E ++++ + E + L +LR +I
Sbjct: 2903 LLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQP 2962
Query: 3969 IRECISDNKSATVELEK 3985
+ + + D+ +E K
Sbjct: 2963 VGDLLIDSLQDHLEKVK 2979
Score = 208 bits (530), Expect = 1e-52
Identities = 113/230 (49%), Positives = 149/230 (64%), Gaps = 5/230 (2%)
Query: 75 ERDRVQKKTFTKWVNKHLMKVRK-HINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRF 133
ER+ VQKKTFTKWVN K K HI +L+ DL+DG L+ LLE L+G KLP+EKG R
Sbjct: 12 EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV 71
Query: 134 HRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESG- 192
H L NV AL L+ V LVNI + DI DGN KLTLGLIW IILH+Q+ ++ + +G
Sbjct: 72 HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL 131
Query: 193 DMSAKEKLLL-WTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQI-QS 250
+ EK+LL W ++ T Y + NF++ WSDG NALIH +RPDL D V QS
Sbjct: 132 QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 191
Query: 251 NRENLEQAFEVAE-RLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPK 299
+ LE AF +A +LG+ +LLD EDVD PD+KS++ Y++S++ P+
Sbjct: 192 ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 241
Score = 196 bits (498), Expect = 5e-49
Identities = 481/2824 (17%), Positives = 1126/2824 (39%), Gaps = 356/2824 (12%)
Query: 1246 QEKGSQLQERWHRV-IAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKP 1303
QE+ + L RW + +A +E +QS L + L + + L W+ +T + ++M +
Sbjct: 421 QEQMNLLNSRWECLRVASME-KQSNLHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEE 477
Query: 1304 GQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVES 1363
D L Q+ Q L ++E+ Q +++ S + +V D
Sbjct: 478 PLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN-----SLTHMVVVVD-------------- 518
Query: 1364 QQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDAL---RRLEEEEKVV 1420
+S G ++ A+ ++ L R+ + T + D L +RL EE+ +
Sbjct: 519 --ESSGDH-----ATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLF 571
Query: 1421 E---EEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTK 1477
EK++ V K+ +T G K+ ++ ++ + VL +L K
Sbjct: 572 SAWLSEKEDAVNKI------------HTTG------FKDQNEMLSSLQKLAVLKADLEKK 613
Query: 1478 KEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA 1537
K+ + + Q L S + K ++++ A + D N +Q+L+ A
Sbjct: 614 KQSMGKLYSLKQDLL-------STLKNKSVTQKTEAWLDNFARCWD---NLVQKLEKSTA 663
Query: 1538 HQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQD 1597
Q Q Q + + + + V E+ L H Q++L + +
Sbjct: 664 -QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKH----AQEELPPPPPQKKRQITVDS 718
Query: 1598 DIQNRA----TSFATVVKDIEGFMEENQTKLSPRE--LTALREKLH----QAKEQYEALQ 1647
+I+ R T + + E ++ + + +E + L+EK++ + E++ LQ
Sbjct: 719 EIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQ 778
Query: 1648 EETRVAQKELEEAVTSALQQETEKSKAAKEL----AENKKKIDALLDWVTSVGSSGGQLL 1703
+ +R AQ +E+ V + ++ K +A+++L E + + L+W+ +
Sbjct: 779 DASRSAQALVEQMVNEGVNADSIK-QASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FY 836
Query: 1704 TNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILAT 1763
L +EQ++ + + T P + Q ++ K L Q I
Sbjct: 837 NQLQQLEQMTTTAENWLKIQPT-----TPSEPTAIKSQLKICKDEVNRLSGLQPQ-IERL 890
Query: 1764 QSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFL 1821
+ L + G L + + +A K++QT+ D L ++
Sbjct: 891 KIQSIALKEKGQG-----PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQ 945
Query: 1822 QDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQK 1881
+ +W+++SE +L + E + L + + + L +++ + ++
Sbjct: 946 ETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE 1005
Query: 1882 VLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSA 1941
+ K PSEI + + ++ R+ L S+ L + + + QN
Sbjct: 1006 M--------SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHI 1057
Query: 1942 DSLQAWMQACEANVEKLLSDT--VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 1999
+L+ WM A V+ L + D +L++QL KQ + +++ Q L V
Sbjct: 1058 QTLKKWM----AEVDVFLKEEWPALGDSEILKKQL---KQCRLLVSDIQTIQPSLNSVNE 1110
Query: 2000 DIMEIEGEPAPDHRHVQETT-DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2058
+I+ E P+ ET + + + + + R L+ + ++ S+Q+ L +
Sbjct: 1111 GGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMH 1170
Query: 2059 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2118
+ + + E+ + + +Q+A+ + K++ ++++ ++ E V + A
Sbjct: 1171 EWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP 1230
Query: 2119 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQFMENKSRML 2177
L+ +L ++ ++ LC + K +L+++ E+ +L + E + ++
Sbjct: 1231 VAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLK 1290
Query: 2178 ASGNQPD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQ 2235
+ N P ++I+ ++ L ED + L +T+ G +D +++ ++
Sbjct: 1291 TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD----GGVMDELINEE-LE 1345
Query: 2236 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL 2295
+ EL + R+K L+ + +ETE S+ + S++ +
Sbjct: 1346 TFNSRWRELHEEAVRRQK--------------LLEQSIQSAQETEKSLHLIQESLTF--I 1389
Query: 2296 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2355
+KQ+ + D A ++I TS E + +E +QGK +
Sbjct: 1390 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHE-ISLEEMKKHNQGKEAA----------- 1437
Query: 2356 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2415
+ Q + DV++K+ L ++ + + L + + E L LE
Sbjct: 1438 ---QRVLSQIDVAQKKLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPALE 1489
Query: 2416 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2475
+K + E V++Q L + +++ V + ++ +
Sbjct: 1490 TKS------------VEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV----QKK 1533
Query: 2476 EAENWKKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELM 2532
+ EN K++ E + + E+ R++QLE+ + + L WL ++
Sbjct: 1534 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1593
Query: 2533 MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ 2592
+ + P+ L+++ + KE E ++ + + E + + T G + V+
Sbjct: 1594 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK---KETLVE 1650
Query: 2593 KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAIST 2652
+L +N W+ +T S+ ++ + +YQ+ ++ + V + + + +
Sbjct: 1651 DKLSLLNSNWIAVT-------SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1703
Query: 2653 QPEAVKQQLEET--SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVAL 2710
+ E K Q +E ++++L + +V + L G D +K +E
Sbjct: 1704 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-----DHCRKLVEPQIS 1758
Query: 2711 PLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 2770
L + RI +A++ ++ +Q +++ L+ P+ A+++ Q
Sbjct: 1759 ELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLE----------PLEAEIQ--QGV 1805
Query: 2771 LQENEEFQKSLNQ-HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKT 2829
+ E+F K +N+ + G+ + ++ G++L + ++ ++ + L+ L
Sbjct: 1806 NLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLR 1865
Query: 2830 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAM 2886
+ R+ + + + +Y+ +DL+ ++D + K++ L D +++ L + K
Sbjct: 1866 SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEE 1925
Query: 2887 LNEVEKRRSLLEILNSAADILINSSEADEDG--IRDEKAGINQNMDAVTEELQAKTGSL- 2943
LN V ++ L +A + + + I + A + A ++ +T +
Sbjct: 1926 LNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVM 1985
Query: 2944 -EEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
E+M + ++ V A LE+ L + K+ E L Q+E L+ ++
Sbjct: 1986 TEDMPLEISYVPSTYLTEITHVSQAL--LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 2043
Query: 3003 -------QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--EVKQRVNSGCVMME 3053
++D + + ++ A + ++ Q ++Q +F +V + +
Sbjct: 2044 SLQQSSGRIDIIHSKKTAALQSA---TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2100
Query: 3054 NKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ--IEDVRLFLNKIHVLK 3111
+E +FH ++ +F+Q ++ I + + + + +++++ + + +
Sbjct: 2101 RSVEKWRRFHYDIK-IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVV 2159
Query: 3112 LDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQ----CGKLTERGKARQEQLELTLGR 3167
+ A+ E ++++ D L+ +L +LN + C +L++R K +EQ +
Sbjct: 2160 RTLNATGEE---IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI---- 2212
Query: 3168 VEDFYRKLKGLNDATTAAEEAEALQWVV---GTEVEIINQQLADFKMFQKEQVDPLQMK- 3223
+ +F R L N+ EEA+ + + G E ++ ++L K+ +E PL+
Sbjct: 2213 LSEFQRDL---NEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL--PLRQGI 2266
Query: 3224 LQQVNGLGQGLIQSAGKDCDVQG-LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF 3282
L+Q+N G ++ SA + Q LE+ +++ N +W +++ + ++ +++ + G+
Sbjct: 2267 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2326
Query: 3283 QDALEPL-------LSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVD 3335
+ LE L L WL+ + P+ E +QE ++ + ++ V+
Sbjct: 2327 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF---DVQETEIA---VQAKQPDVE 2380
Query: 3336 MLQAEGGRIAQSAELADREKITGQLESLESRW---TELLSKAAARQKQLEDIL------- 3385
+ ++G + + E + + +LE L S W LL + A+Q L L
Sbjct: 2381 EILSKGQHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 2438
Query: 3386 ----------VLAKQ---------------------FHETAEPISDFLSVTEKKLANSEP 3414
V+ K+ F+ ++D+LS+ ++ + +
Sbjct: 2439 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2498
Query: 3415 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQ 3473
+ I + II+ KA +D+E + + + Q+L + TS E + +++++I+ +Q
Sbjct: 2499 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2558
Query: 3474 ARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHR 3533
++ E+Q+ + L++ L ++ + E + E L + KL S + D + +
Sbjct: 2559 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2618
Query: 3534 QHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSS 3593
+ + L +++ + NVD A LL+ + ++ + + I + I S
Sbjct: 2619 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2678
Query: 3594 KALRTLEQARQLATKFQSTYEELTGWLREVE------EELATSGGQSPTGEQIPQFQQRQ 3647
+ LE+ +L +F E+ WL E E ++ + + + ++
Sbjct: 2679 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 2738
Query: 3648 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLV------SDANEQYKLVSDTI 3701
++L+ E+ H V ++E S+ +L R+ EG D V + N ++ +
Sbjct: 2739 QDLQGEIEAHTDVYHNLDENSQKIL-----RSLEGSDDAVLLQRRLDNMNFKWSELRKKS 2793
Query: 3702 GQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF-- 3759
++A+ + ++ + L W+ +L PI + Q V +AF
Sbjct: 2794 LNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKR 2853
Query: 3760 -----------SIDIIR------HKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQ 3801
+++ +R + +++L+ E+ + T +L+++ E +
Sbjct: 2854 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNT 2913
Query: 3802 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQ 3860
++E ++L +++ +++ + + E +EL + + + P + + L+
Sbjct: 2914 EWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQD 2973
Query: 3861 QQEEMRQLRESIAEHKPHIDKLLKIGPQLK----ELNPEEGEMVEEKYQKAENMYAQIKE 3916
E+++ LR IA K ++ + + QL +L+P +E+ + + + +++
Sbjct: 2974 HLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVED 3033
Query: 3917 EVRQ 3920
VRQ
Sbjct: 3034 RVRQ 3037
Score = 184 bits (467), Expect = 2e-45
Identities = 361/1991 (18%), Positives = 773/1991 (38%), Gaps = 283/1991 (14%)
Query: 3270 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDD 3329
+ L E+ ++ ++Q ALE +LSWL E+ + Q S + +VVK Q + L
Sbjct: 332 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
Query: 3330 RKATVDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTELLSKAAARQKQLEDILVL 3387
+ V + G ++ + +L++ E+ + Q+ L SRW L + A+ +KQ VL
Sbjct: 392 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL--RVASMEKQSNLHRVL 449
Query: 3388 AKQFHETAEPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3445
++ + ++D+L+ TE++ EP+G +++Q+ +HK L+ED+E V+
Sbjct: 450 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 509
Query: 3446 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 3505
+ + + L E++ L R++ I + LL L + E++
Sbjct: 510 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQC 569
Query: 3506 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA-LNEEIVNRKKNVDQAIKNGQALLK 3564
WL+E ED ++ + FK LA L ++ +K+++ + Q LL
Sbjct: 570 LFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLS 629
Query: 3565 QTTGEEVLLIQEKL--------DGIKTRYADITVTSSKALRTLEQARQLATKFQS----- 3611
+ V E D + + T S+A+ T + + T ++
Sbjct: 630 TLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 689
Query: 3612 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVME-HRLVLDTVNEVSRA 3670
T E++ ++ +EEL Q QI + +K L ++ E H + T +E
Sbjct: 690 TREQIL--VKHAQEELPPPPPQKK--RQITVDSEIRKRLDVDITELHSWI--TRSEAVLQ 743
Query: 3671 LLELVPWRAREGLDKLVSDAN-------EQYKLVSDT-------IGQRVDE---IDAAIQ 3713
E +R L N E+++ + D + Q V+E D+ Q
Sbjct: 744 SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQ 803
Query: 3714 RSQQYE-------QAADAELAWVAETKRKLMALGPIR-LEQDQTTAQ--LQVQK------ 3757
S+Q Q L W+ + ++ LEQ TTA+ L++Q
Sbjct: 804 ASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP 863
Query: 3758 -AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES-LIQQYEAISLLN----- 3810
A + KD ++ L + +I + Q L+EK + + + ++ N
Sbjct: 864 TAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQV 921
Query: 3811 -SERYARLERAQVLVN-----QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 3864
S+ AR + Q + + ++ ET + W++++ ++ D+E + Q+ E
Sbjct: 922 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 981
Query: 3865 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALA 3924
++ L+ S+ E + L + +KE++ + + KYQ EE+ R
Sbjct: 982 LQALQSSLQEQQ---SGLYYLSTTVKEMSKKAPSEISRKYQSEF-------EEIEGRWKK 1031
Query: 3925 LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK--------------IR 3970
L S+Q+ E K+E + L + + ++ AEVD ++
Sbjct: 1032 L------SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 1085
Query: 3971 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4030
+ + + +++ +QPS ++ G+++ A+ + A++ ++ +L ++ W+ +
Sbjct: 1086 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKI---KNEAEPEFASR-LETELKELNTQWDHM 1141
Query: 4031 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4090
+ R+ LE D++ + + ++ + + P +++ VE +
Sbjct: 1142 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1201
Query: 4091 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4150
KEE +++ + +I + ++K ++ + ++ L + + L
Sbjct: 1202 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1261
Query: 4151 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MPPVGTDLNTVKDQL-NEMKEFKVEVY 4206
E+ + L+ WL+ KL T +P +++ V D L N M+ +
Sbjct: 1262 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1321
Query: 4207 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4266
Q +I + L G + ++I E L W L E+ RQ LE ++ +
Sbjct: 1322 QIRILAQTLTDGGVM----------DELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1371
Query: 4267 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326
+ + +L + LT ++ L A D + E K +++D+ +H+ ++E +
Sbjct: 1372 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMK 1428
Query: 4327 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4386
K + + A + S+++ + + V K Q+ F +++
Sbjct: 1429 K------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQKPANFEQRLQES 1474
Query: 4387 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4446
+ L ++ L A + E + QL+ + LY L + ++ GR ++ +
Sbjct: 1475 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR-QIVQKK 1533
Query: 4447 DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQS 4506
+ + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + + + WL +
Sbjct: 1534 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1593
Query: 4507 LNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 4566
L S + + + S++ K E+ + + + + G LK + K++ L+++
Sbjct: 1594 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-LVEDK 1652
Query: 4567 LVSVQSRWEKVVQRS----------------------------IERGRSLDDA-RKRAKQ 4597
L + S W V R+ I+ LD++ +K+ +Q
Sbjct: 1653 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1712
Query: 4598 FHEAWKKLIDWLEDAESHLDSELE-----ISNDPD------------------------- 4627
+ K+L L D +DS + ++N D
Sbjct: 1713 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1772
Query: 4628 --KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 4685
K + L + ++F + + I+ G LKE+ + ++ + + E+ + D
Sbjct: 1773 TGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGD 1832
Query: 4686 TVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLYKVEPQLAEDQP 4731
+ + + + + E + L S + AL+ W Y+ + Q +
Sbjct: 1833 NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-YQYKRQADDLLK 1891
Query: 4732 VHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 4785
D++ + + D K+ +EL K+ + ++R L E+ V+
Sbjct: 1892 CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--AMAVEPTQ 1949
Query: 4786 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTE 4845
+LS RW + + ++ RL A Q R+ M++ E + L + T
Sbjct: 1950 IQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 2006
Query: 4846 ALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 4893
Q+L++ + E + K EE ++ ++ + + H ++
Sbjct: 2007 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2066
Query: 4894 ITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEELLAWIQWAETT 4942
+ R + +E L+ W K Q R + ++ + ++ W+ AE
Sbjct: 2067 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2126
Query: 4943 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKS 5002
L + IP+N + K ++ +++E+ V +T
Sbjct: 2127 LRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN--------------- 2163
Query: 5003 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5062
+ G + + Q + IL + ++ L+ RWQ+V +R+++L + + L E
Sbjct: 2164 -ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEF 2216
Query: 5063 KEFANFDFDVW 5073
+ N +F +W
Sbjct: 2217 QRDLN-EFVLW 2226
Score = 91.3 bits (225), Expect = 2e-17
Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 31/555 (5%)
Query: 4585 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 4644
G SL ++ ++ A ++++ WL AE L ++ EISND + +K Q H+ + L
Sbjct: 331 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 390
Query: 4645 GKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 4703
Q ++ G L L ED + ++ + + +W+ + S+E+Q L L+
Sbjct: 391 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450
Query: 4704 FSGQFMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 4761
L+ L DWL K E + E++P+ DL+ + + HKV Q++L + V
Sbjct: 451 DLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 508
Query: 4762 VLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 4820
L + E+S D T ++ QL+ L RW +C+ + + L+ L + + +
Sbjct: 509 SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 568
Query: 4821 HMLLEWLSEAEQTLR--FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVI 4878
+ WLSE E + D E L SL +E+K+ + ++ + +
Sbjct: 569 CLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL-QKLAVLKADLEKKKQSMGKLYSLKQDL 627
Query: 4879 LAVCHPDCIT-TIKHWITIIRARFEEVLTWAKQHQQRLETAL--SELVANAELLEELLAW 4935
L+ +T + W+ ++ ++ ++ ++ A+ ++ + E +
Sbjct: 628 LSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 687
Query: 4936 IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIE 4992
+ E L++ QE +P + K Q ++ RK+ DVD +T+ + R
Sbjct: 688 VTTREQILVKHAQEELPPPPPQKK-----RQITVDSEIRKRLDVD-ITELHSWITRSEAV 741
Query: 4993 PTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKL 5052
F + G L + + + + +A+ R Q ++R Q + + +
Sbjct: 742 LQSPEFAIFRKEGNFSDLKE----KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 797
Query: 5053 NDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5112
D++ + E +F + + W+ + ++ ++ F+ ++ + + T + ++
Sbjct: 798 ADSIKQASEQLNSRWIEFCQLLSERLNWLEY-QNNIIAFYNQLQQLEQMTTTAENWL--- 853
Query: 5113 LASKFPTTKLEMTAV 5127
PTT E TA+
Sbjct: 854 --KIQPTTPSEPTAI 866
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 345 bits (885), Expect = 7e-94
Identities = 762/3642 (20%), Positives = 1389/3642 (38%), Gaps = 526/3642 (14%)
Query: 78 RVQKKTFTKWVNKHLM--KVRKHINDLYEDLRDGHNLISLLEVLSGIKLPR-EKGRMRFH 134
++Q+KTFTKW+N + I +LY +L DG +L+ LLE++SG LP +GR+R H
Sbjct: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
Query: 135 RLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGDM 194
L+N AL FL+ + V + I ++I DG+ L LGLIW IIL FQIS I + E
Sbjct: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
Query: 195 SA-----KEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQ 249
SA KE LL+W Q+ TA YT + T+FS WSDG FNALIH +RPDL+D ++
Sbjct: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
Query: 250 SNRENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEG-- 306
NL AF VAE+ LG+ +LLD EDV PDE+S++TYVS Y ++ +G
Sbjct: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
Query: 307 ------ISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK 360
+ E + +Y+ V L+ WI + + + + FP + ++ L + F+
Sbjct: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
Query: 361 ETEILAKEREKGRIEELYKLLEVWIEF--GRIKLP-QGYHPNDVEEEWGKLIIEMLEREK 417
E + +++G E L L+ ++ R LP +G ++ + W L R +
Sbjct: 318 TQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQ 377
Query: 418 SLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYI 477
+L+ + +L+ L +A + Q+ A E L A+ L A S V+ + +
Sbjct: 378 ALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGML 437
Query: 478 Q----ECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT 533
+ EG + L ILR E Y+ ++A R E VT+R +
Sbjct: 438 EAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ----------- 481
Query: 534 SLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELL 593
HL+ + RK + A++ A+ S L+ V
Sbjct: 482 ---------RLLQHLQGQ--------------RKQV--ADMQAVLSL-----LQEVEAAS 511
Query: 594 SWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTS 653
+EE+Q G L V L+ + V G+ V ++ + TS
Sbjct: 512 HQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTS 571
Query: 654 Y------AETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYD 707
A TL +L+ L + +F+ E WL E +
Sbjct: 572 VEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAA 631
Query: 708 WSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQ 767
+ S I+ L E+ Q V L LS P + + AVQ
Sbjct: 632 LGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGG 691
Query: 768 LQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLS----- 822
Q ++ + ++ Q+F+DA E S+LR + S++R SC + + +
Sbjct: 692 WQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERA-SCGQDQAAAETLLR 750
Query: 823 ---RLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKN---------- 869
RLE +L+ E +L + + ++ L P P L+N
Sbjct: 751 RHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP--PGESLRNPGPWSEASCH 808
Query: 870 -------TISVKAVCDYRQIEITICKNDECVLED-NSQRTKWKVISPTGNEAMV------ 915
+++ A D TI + + + +D S R ++ EAM
Sbjct: 809 PGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCS 868
Query: 916 -----------PSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLR 964
+V P D +E+ +++ +A+ L S
Sbjct: 869 SCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSS-------- 920
Query: 965 KDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEA 1024
+ E+LR PG QI Q E+ Q ++L VE
Sbjct: 921 ---------SAEQLRQRYPGNSTQI----QRQQEELSQRWGQLEALKREKAVQLAHSVEV 967
Query: 1025 C---------KARFQHL---MKSMENEDKEETVAKMYISELKNIRL-RLEEYEQRVVKRI 1071
C + + + + +++++ E+T + +++ K + L R + Q VV ++
Sbjct: 968 CSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKV 1027
Query: 1072 QSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTL 1131
+ + + Q L+ + QE + Q R+ A + SFL +S
Sbjct: 1028 EEPGYAESQPLQGQVETLQ-GLLKQVQEQVAQ-RARRQAETQARQSFLQES--------- 1076
Query: 1132 RSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLS 1191
+L L E + V ++ + + ++R QD + ++ +L Q + ++
Sbjct: 1077 -QQLLLWAESVQAQLRSKEVSVD-VASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMA 1134
Query: 1192 ALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERY--QEKG 1249
AL+ D ++ + VL ++ + KV+ EQ + E L+L+++ + G
Sbjct: 1135 ALDC---------PDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQE-GLELQKFGREVDG 1184
Query: 1250 SQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWI----EETTAQQEMMKPGQ 1305
H+ L+ ++ +L +R G L+ + E A E + Q
Sbjct: 1185 FTATCANHQAWLHLDNLGEDVREALSLLQQHRE-FGRLLSTLGPRAEALRAHGEKLVQSQ 1243
Query: 1306 AEDSRVLSEQL----SQQTALFAEIERNQTKL---DQCQKFSQQYSTIVKDYELQLMTYK 1358
+ + EQL +Q T L E+ + +L Q Q++ Q + + +Q M K
Sbjct: 1244 HPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAEL-----MQWMEEK 1298
Query: 1359 AFVESQQKSPGKRR--RMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEE 1416
+ + + S +R + L +A E + T +HV+ + R L
Sbjct: 1299 GLMAAHEPSGARRNILQTLKRHEAAESELL-----------ATRRHVEALQQVGRELLSR 1347
Query: 1417 EKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTT 1476
+E+ Q ++ ++ + + L+ ++T
Sbjct: 1348 RPCGQEDIQTRLQGLRS--------------------------------KWEALNRKMTE 1375
Query: 1477 KKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQL 1536
+ +++ +A + Q+ ++ + EQL L A S+ Q L+S
Sbjct: 1376 RGDELQQAGQQEQLL----------RQLQDAKEQLEQLEGALQ-----SSETGQDLRSSQ 1420
Query: 1537 AHQTEQKTLQKQQNTCHQQLEDLCSWV-GQAERALAGHQGRTTQQDLSALQKNQSDL--K 1593
Q + L+ + T ++ L S G A + TQ+ L L+ Q L +
Sbjct: 1421 RLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEE---TQKHLRRLELLQGHLAIR 1477
Query: 1594 DLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVA 1653
LQ F + ++ E+ SP T +++ LQ E +
Sbjct: 1478 GLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAH 1537
Query: 1654 QKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ-- 1711
Q +++ ++S A+ + E ++++ + + Q L +Q
Sbjct: 1538 QGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYF 1597
Query: 1712 -----LSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSA 1766
L G EK L ++ Y A +L +HQ L Q + S+
Sbjct: 1598 LDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN-------KHQAL----QEELAIYWSS 1646
Query: 1767 QAFLDQHGHNLT----PEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ 1822
LDQ LT PE+Q+++Q++L E A + EL+ TL+ L +FL+
Sbjct: 1647 MEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDRELE--GTLR--LHEFLR 1702
Query: 1823 DHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKV 1882
+ ++ + WL ++ + G PE L + F V + + + +
Sbjct: 1703 EAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESL 1762
Query: 1883 L---------------DMENSFKEGKEPSEI-GNLVKDK------LKDATERYTALHSKC 1920
L D++ ++ E E ++ G+ ++D +D E T + K
Sbjct: 1763 LERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKA 1822
Query: 1921 TRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASD---PG-----VLQE 1972
T L +++ L S L+ + E +++LL PG V Q
Sbjct: 1823 TSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQR 1882
Query: 1973 QLATTKQ---LQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHR-----HVQETTDS--- 2021
Q A T+ LQ + + + +E+ + +AR + + R V+E++
Sbjct: 1883 QQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSS 1942
Query: 2022 ---ILSHFQSLSYSLAERSSLLQKAIAQSQ-----------SVQESLESLLQSIGEVEQN 2067
LS Q L L R L Q+A Q VQE L +L +V Q
Sbjct: 1943 GPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQT 2002
Query: 2068 LEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGK 2127
KQ + Q L +L++ +A Q+ SL+ + S+ V Q
Sbjct: 2003 WARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTS---------ALGSSVEEVEQ-- 2051
Query: 2128 LAEVSQRFEQLCLQQQEKESSLK---KLLPQAEMFEHLSGKLQQFMENK----------- 2173
L + F ++ Q +KE++L+ K L + + + L LQ+ M K
Sbjct: 2052 LIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALH 2111
Query: 2174 -SRMLAS----GNQPDQDITHFFQQIQELNLEMEDQQENLDTL-------------EHLV 2215
S ++AS Q + I + QQ++E + D ++ L L E ++
Sbjct: 2112 ASLLMASFTQAATQAEDWIQAWAQQLKE-PVPPGDLRDKLKPLLKHQAFEAEVQAHEEVM 2170
Query: 2216 TELSSCGFALDLCQH------QDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLV 2269
T ++ G AL H R+Q LRK + +L++ + R ++ + L EF + V
Sbjct: 2171 TSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL-EFLQRV 2229
Query: 2270 RTFQKWLKETEGSIPPTETSMSAKELEKQIEH---LKSLLDDWA--SKGTLVEEINCKGT 2324
+ W++E E M+ +L + +EH L+ L ++ S G V + +
Sbjct: 2230 DLAEAWIQE-------KEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSI 2282
Query: 2325 SLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCD-MSDVNLKYEKLG 2383
S +L ++ P+ +I C S +N ++
Sbjct: 2283 SDLSLQLKNRDPEE---------------------------VKIICQRRSQLNNRWASFH 2315
Query: 2384 GVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN 2443
G L Q+ L+ L + + +E ++V + ++ KE +++++D E+V+ +
Sbjct: 2316 GNLLRYQQQLEGAL-EIHVLSRELDNVTKRIQEKEALIQALDCGKD---LESVQRLLRKH 2371
Query: 2444 KAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR 2503
+ E+ +++ ++ + L P + A + Q+E+ W + R+
Sbjct: 2372 EELEREVHPIQAQVESLEREVGRLCQRSP--EAAHGLRHRQQEVAESWWQLRSRAQKRRE 2429
Query: 2504 QLEESASHLACFQAAESQLRPWLMEKELMMGVL--GPLSIDPNMLNAQKQQVQFMLKEFE 2561
L+ A H A Q ++ L+ L+ + + + P P ++ Q E +
Sbjct: 2430 ALD--ALHQA--QKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELD 2485
Query: 2562 ARRQQHEQLNEAAQGILTGPGDVSLSTSQV----QKELQSINQKWVELTDKLNSRSSQID 2617
+ Q +LT S QV ++EL S+ W E Q+
Sbjct: 2486 SWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQE-------HQLQLQ 2538
Query: 2618 QAIVKSTQYQELLQDLSEKVR-AVGQRLSVQSAISTQPEA-VKQQLEETSEIRSDLEQLD 2675
QA+ + Q L + + R + S+ S P A ++ L + + DLE
Sbjct: 2539 QAL----ELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQA 2594
Query: 2676 HEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQ 2735
++ + L G R + + L + L A R +RL+ L Q
Sbjct: 2595 GKISALEATARGLHQ--GGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLE-ELRQLQA 2651
Query: 2736 FQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEG 2795
F Q E+ WL +K + + + L +QLQ+ + FQ L+ + + EG
Sbjct: 2652 FLQDSQEVAAWLREKNLVALEEGLLDTAM--LPAQLQKQQNFQAELDASMHQQQELQREG 2709
Query: 2796 ESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVP 2855
+ LL P E +Q +L EL W EL + + ++L+ + A + + +E+L
Sbjct: 2710 QRLLQGGHPASE--AIQERLEELGALWGELQDNSQKKVAKLQKACE-ALRLRRSMEELEN 2766
Query: 2856 WIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADE 2915
W+E + ++ V + L + + V+K+ E L A +
Sbjct: 2767 WLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLA 2826
Query: 2916 DGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFD 2975
+ ++ + Q ++ E LQ + +LE + L+ F+++ ++++ + +L
Sbjct: 2827 QDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDA----DEEMAWVQEKL---- 2878
Query: 2976 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQL-LHQAEVA 3034
L + ++L +R QE Q LE ++ T+ ++ A H+
Sbjct: 2879 PLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAAR 2938
Query: 3035 QQEFLEVKQRVNSGCV---MMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTD 3091
Q+ + + + ++ + + QF + E S LA+ L D++
Sbjct: 2939 VQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVL--------DSE 2990
Query: 3092 SLQSQIEDVRLFLNKIHVLKLDIEASEAECRH------MLEEEGTLDLLGLKRELEALNK 3145
+ E + L ++ K D+EA +LE + + +L+A+ +
Sbjct: 2991 DMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVRE 3050
Query: 3146 QCGKLTERGKAR----QEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEI 3201
+L R +AR QEQL+L E L DA + A A G ++E
Sbjct: 3051 AHAELLRRAEARGHGLQEQLQLHQLERETL------LLDAWLTTKAATAESQDYGQDLEG 3104
Query: 3202 INQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTL 3261
+ F F+KE Q K+ + L L + A + ++ I A W L
Sbjct: 3105 VKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPR--RYPHIQAQRSRIEAAWERL 3162
Query: 3262 NKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQK 3321
++ + R L A FQ A L + + L+ + + V Q Q+ +
Sbjct: 3163 DQAIKARTENL-AAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQ-QQHR 3220
Query: 3322 LLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQL 3381
L+R L+ + V LQ E R+ Q A G L ++ W L +KA R + L
Sbjct: 3221 RLERELEAMEKEVARLQTEACRLGQLHPAA-----PGGLAKVQEAWATLQAKAQERGQWL 3275
Query: 3382 EDILVLAKQFHETAEPISDFLSVTEKK--LANSEPVGTQTAKIQQQIIRHKALEEDIENH 3439
A Q H + L+ +++ LA+SE + A +Q + +H+ L ++I
Sbjct: 3276 AQ----AAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIREC 3331
Query: 3440 ATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQD 3481
+ GQ L S ++E + L+ R E+++
Sbjct: 3332 RLQAQDLRQEGQQLVD-NSHFMSAEVTECLQELEGRLQELEE 3372
Score = 219 bits (557), Expect = 8e-56
Identities = 481/2424 (19%), Positives = 964/2424 (39%), Gaps = 264/2424 (10%)
Query: 2713 QGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQ 2772
+ L LA R RL+ A+A F EL+ WL+ + + P + LE +Q +
Sbjct: 844 ESLRALAQLRRARLEEAMALFG-FCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKY- 901
Query: 2773 ENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADR 2832
E F +L G + + + E L P + +Q Q EL W +L ++
Sbjct: 902 --ENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ--IQRQQEELSQRWGQLEALKREK 957
Query: 2833 QSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA----MLN 2888
+L H ++ ++++C +LR L +QLE+ S L
Sbjct: 958 AVQLA-----------HSVEVCSFLQECGPTQVQLRDVL--LQLEALQPGSSEDTCHALQ 1004
Query: 2889 EVEKRRSLLE----ILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEEL------QA 2938
+K+ +LE L S + A+ ++ + + + V E++ QA
Sbjct: 1005 LAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQA 1064
Query: 2939 KTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQ 2998
+T + + Q ++ ++++ ++ + +++ A LE++ QE LQ
Sbjct: 1065 ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQ 1124
Query: 2999 ALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG 3058
L+ Q + D PD + L V Q+ E+K ++ LE
Sbjct: 1125 QLDAQSQPMAAL------DCPDSQEVPNTLR---VLGQQGQELKVLWEQRQQWLQEGLE- 1174
Query: 3059 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3118
+ +F V + A+ L + +G D S ++ R F + L EA
Sbjct: 1175 LQKFGREVDGFTATCANHQAWLH-LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALR 1233
Query: 3119 AECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGL 3178
A +++ + ++ +L+++ Q +L R + R+ QL L L
Sbjct: 1234 AHGEKLVQSQHPAAHT-VREQLQSIQAQWTRLQGRSEQRRRQL-------------LASL 1279
Query: 3179 NDATTAAEEAEALQWVVGTEVEIINQQ-------LADFKMFQKEQVDPLQMK--LQQVNG 3229
+ AE +QW+ + ++ L K + + + L + ++ +
Sbjct: 1280 QLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQ 1339
Query: 3230 LGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPL 3289
+G+ L+ + C + ++ ++ + ++W LN+K+ +R +LQ+A E L
Sbjct: 1340 VGRELLSR--RPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQA--------GQQEQL 1389
Query: 3290 LSWLADTEELIANQK---PPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG----G 3342
L L D +E + + S + +++ + QK Q+L + + + A G
Sbjct: 1390 LRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHG 1449
Query: 3343 RIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFL 3402
A A L + +K +LE L+ A R QL+ + + H+ + L
Sbjct: 1450 MAASPAILEETQKHLRRLELLQGH-------LAIRGLQLQ----ASVELHQFCHLSNMEL 1498
Query: 3403 SVTEKKLANSEPVG-TQTAKIQQQIIR-HKALEEDIENHATDVHQAVKIGQSLSSLTSPA 3460
S + + + P T+ Q + R HK L+ +++ H V + + G+SL++ P
Sbjct: 1499 SWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQ 1558
Query: 3461 EQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSS 3520
Q ++ E+ L+ ++E++ C +A L QA++ + F D E+ W VE+K
Sbjct: 1559 AQHIV-EQCQELEGHWAELERACEARAQCLQQAVTFQQYF-LDVSELEGW---VEEKRPL 1613
Query: 3521 VFVKDFKQD--VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL 3578
V +D+ +D R H AL EE+ ++++ + Q L E+ ++QE+L
Sbjct: 1614 VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERL 1673
Query: 3579 DGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGE 3638
++ T R LE +L +F E+L GWL ++ A GG+S GE
Sbjct: 1674 REQLRALQELAATRD---RELEGTLRLH-EFLREAEDLQGWL--ASQKQAAKGGES-LGE 1726
Query: 3639 ----------QIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS 3688
+ +FQ + + + V RL+ +++ E + +V R ++ L +
Sbjct: 1727 DPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD----LQT 1782
Query: 3689 DANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQ 3748
+E ++L + G + + + ++ + L + + + K +L P + +D
Sbjct: 1783 AWSELWEL-TQARGHALRDTETTLRVHRDL-------LEVLTQVQEKATSL-PNNVARDL 1833
Query: 3749 T--TAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI 3806
AQL+ + +++ + + EL + C Q +Q++ +++ Q + +
Sbjct: 1834 CGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVL 1893
Query: 3807 SLLNSERYARLERAQVLVNQFWETYEELSPW---------IEETRALIAQLPSPAIDHEQ 3857
+R A+LERA++L +F + + W +EE+ + P H+
Sbjct: 1894 QRRMEQRRAQLERARLLA-RFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQW 1952
Query: 3858 LRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQ-------KAENM 3910
LR + E +L + + LL G KE+ E + +++ Q K E +
Sbjct: 1953 LRAELEAREKLWQQATQLGQQA--LLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERL 2010
Query: 3911 YAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 3970
A+ +E++ R E + + +++ + +E +E L + + + DK
Sbjct: 2011 QAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDK-- 2068
Query: 3971 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4030
K A + E+L K L ++D+L ++ +
Sbjct: 2069 ------KEAALR-ERL----------------------KTLRRPRVRDRLPILLQRRMRV 2099
Query: 4031 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKD-TQDIVHDLESPGIDPSIIKQQVEAA 4089
K AE R L +A + AA T +D Q L+ P + P ++ +++
Sbjct: 2100 KELAESRGHALHASLLMAS---FTQAA--TQAEDWIQAWAQQLKEP-VPPGDLRDKLKPL 2153
Query: 4090 ---ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER 4146
+ + E HEE+ + + A EV + + + WE+L + R
Sbjct: 2154 LKHQAFEAEVQA-HEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALR 2212
Query: 4147 LEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVY 4206
++LED +++ + W+ +K+ + +G DL ++EF+
Sbjct: 2213 GQELEDRRNF-LEFLQRVDLAEAWIQEKEVKM-NVGDLGQDLEHCLQLRRRLREFRGNSA 2270
Query: 4207 QQQIEMEKLNHQGELMLK-KATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL 4265
+ + +L L+ K D + II + ++L + W + + Q +LEGAL
Sbjct: 2271 GDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGAL- 2329
Query: 4266 ALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETV 4325
+ L+ + + E L+ A D + ++ L KH L+ +V QA VE++
Sbjct: 2330 EIHVLSRELDNVTKRIQEKEALIQAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESL 2388
Query: 4326 NKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIED 4385
+ L + S + A LR R + + + W + + ++R + L + L QAQ + +++
Sbjct: 2389 EREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAMLQE 2446
Query: 4386 FLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSR 4445
L+ R+ +Q+ S P P AR L+ H E ++L + ++ + G+ +L +
Sbjct: 2447 LLVSAQRLRAQMDTS-PAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAG 2505
Query: 4446 DDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQ 4505
S + Q +A LEQ+ + +E + +L++AL L F +S+++ WL E
Sbjct: 2506 HPFSSDIR--QVLAGLEQELSSLEGAWQEHQLQLQQALELQL-FLSSVEKMERWLCSKED 2562
Query: 4506 SLNIASPPSLILNTVLSQIE----EHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVV 4561
SL S L L+ +E +HK+ ++ +I L+ T L +
Sbjct: 2563 SL-----ASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQS 2617
Query: 4562 LIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE 4621
+ + R E + +++ R L++ R+ + F + +++ WL E +L + E
Sbjct: 2618 ALGRCQAMLL-RKEALFRQAGTRRHRLEELRQ-LQAFLQDSQEVAAWLR--EKNLVALEE 2673
Query: 4622 ISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKE-----KTLLPEDSQKLDNF 4676
D + QL K + FQ L R G+ L + + E ++L
Sbjct: 2674 GLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGAL 2733
Query: 4677 LGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGD- 4735
GE++D K V + K EAL + +++ L +WL +E +L P G
Sbjct: 2734 WGELQDNSQ----KKVAKLQKACEAL----RLRRSMEELENWLEPIEVELRA--PTVGQA 2783
Query: 4736 LDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTV 4795
L V L+ + + + K+ + L + + V+ Q + L R+ ++
Sbjct: 2784 LPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSL 2843
Query: 4796 CKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHK 4855
+ +++ LE + FRD + W+ E + L A++ L + H+
Sbjct: 2844 REPLQERRTALEARSLLLKFFRDADEEMA-WVQE-KLPLAAAQDYGQSLSAVRHLQEQHQ 2901
Query: 4856 EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRL 4915
++ + G ++ H H + + E+ + + R
Sbjct: 2902 NLESEMSSHEALTRVVLGTGYKLVQAGH-----FAAHEVAARVQQLEKAMAHLRAEAARR 2956
Query: 4916 ETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRK 4975
L + + L ELL W D E + + + +AL+ + ++
Sbjct: 2957 RLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAF 3016
Query: 4976 QPDVDRVTKT----YKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRI 5031
P ++R+ +T RKN E +P + R++ ++ +L ++EA+ +
Sbjct: 3017 SPRIERLQQTAALLESRKNPE---SPKVLAQLQAVREAHAE-------LLRRAEARGHGL 3066
Query: 5032 NQLSARWQQVWLLALERQRKLNDA 5055
+Q+ L LER+ L DA
Sbjct: 3067 Q------EQLQLHQLERETLLLDA 3084
Score = 209 bits (533), Expect = 5e-53
Identities = 673/3423 (19%), Positives = 1315/3423 (38%), Gaps = 451/3423 (13%)
Query: 1573 HQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRE---- 1628
HQG+T Q+ L+ + + + LQ T + +V D+ ++ E Q +L R+
Sbjct: 250 HQGQTVQRRLTKILLQLQETELLQ-------TQYEQLVADLLRWIAEKQMQLEARDFPDS 302
Query: 1629 LTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDAL 1688
L A+R+ L A + ++ R+ Q+ EA+ LQ + L + L
Sbjct: 303 LPAMRQLL-AAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAEL 361
Query: 1689 ------LDWVTSVGSSG-GQLLTNLPGMEQLSGASLEKGALDTT---DGYMGVNQA---P 1735
L+W + S Q L L +E L+ K AL + D ++QA P
Sbjct: 362 SQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPP 421
Query: 1736 EKL---DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGEL 1792
L + + + +L Q+ F + A + H+ + ++ E+
Sbjct: 422 ASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWAD-----VARRQEEV 476
Query: 1793 KEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLP 1852
++ L + + KQV +Q L LQ+ + LE ++ + G E +
Sbjct: 477 TVRWQRLLQHLQGQRKQVADMQAVLS-LLQEVEAASHQLEELQEPARSTACGQQLAEVV- 534
Query: 1853 SLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATER 1912
LL+R V +H + + Q+ ++++S E +++ K + +
Sbjct: 535 ELLQRHDLLEAQVSAHGAHVSHLA---QQTAELDSSLGTSVE------VLQAKARTLAQL 585
Query: 1913 YTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANV-EKLLSDTVASDPGVLQ 1971
+L + + L L Q +F + + +AW++ C V L ++ G LQ
Sbjct: 586 QQSLVALVRARRALLEQTL-QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQ 644
Query: 1972 EQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS---------- 2021
+ K L+ E+ HQ L + RD+ PD E
Sbjct: 645 KH----KALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVV 700
Query: 2022 -----------ILSHF----QSLSYSLAERSSLLQKAIAQSQSVQES-------LESLLQ 2059
+L +F ++ S+ RSSL + + Q Q+ E+ LE +L+
Sbjct: 701 GRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLR 760
Query: 2060 SIGEVEQNLE--GKQVSSLSS-GVIQEALAT-NMKLKQDIARQKSSLEA----TREMVTR 2111
+ + LE G+ S+ +S + AL+ L+ ++S +M
Sbjct: 761 AFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALP 820
Query: 2112 FMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLS--GKLQQF 2169
D +LQ + +SQ +E L Q + + L++ + +F S G+LQ +
Sbjct: 821 AEPDPDFDPNTILQTQ-DHLSQDYESLRALAQLRRARLEEAMA---LFGFCSSCGELQLW 876
Query: 2170 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---- 2225
+E K +L QP D ++ + L+ E+ L + L E+SS L
Sbjct: 877 LE-KQTVLLQRVQPQADT------LEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRY 929
Query: 2226 --DLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI 2283
+ Q Q + + L + + +L+ +E+ + E V +F + T+ +
Sbjct: 930 PGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVE--------VCSFLQECGPTQVQL 981
Query: 2284 PPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG 2343
+ A + + +L A K TLV E L+++++++ P
Sbjct: 982 RDVLLQLEALQPGSSEDTCHAL--QLAQKKTLVLERRVH--FLQSVVVKVEEP------- 1030
Query: 2344 SILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEV 2403
GY + L + E L G+L + QE + R E
Sbjct: 1031 --------------GYAESQPLQG----------QVETLQGLLKQVQEQVAQRARRQAET 1066
Query: 2404 H------KEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKI 2457
+E+ +L W ES + L+S + + + + + + ++ ++
Sbjct: 1067 QARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQL 1126
Query: 2458 QKVKEALAGLLVTYPNSQEAENWKKIQ----EELNSRWERATEVTVARQRQLEESASHLA 2513
+ +A L P+SQE N ++ +EL WE+ + + +L++ +
Sbjct: 1127 DAQSQPMAAL--DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQ-WLQEGLELQKFGREVD 1183
Query: 2514 CFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEF----EARRQQHEQ 2569
F A + + WL L V LS L Q ++ +L EA R E+
Sbjct: 1184 GFTATCANHQAWLHLDNLGEDVREALS-----LLQQHREFGRLLSTLGPRAEALRAHGEK 1238
Query: 2570 LNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQEL 2629
L ++ + V+++LQSI +W +L RS Q + ++ S Q QE
Sbjct: 1239 LVQSQHP----------AAHTVREQLQSIQAQWT----RLQGRSEQRRRQLLASLQLQEW 1284
Query: 2630 LQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELS 2689
QD++E ++ + ++ + + +P ++ + +T + HE E++ L
Sbjct: 1285 KQDVAELMQWMEEKGLMAAH---EPSGARRNILQTLK--------RHEAAESELLATRRH 1333
Query: 2690 VLIGEQYLKDELKKR---LETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTW 2746
V +Q ++ L +R E + LQGL + +NR Q ++L
Sbjct: 1334 VEALQQVGRELLSRRPCGQEDIQTRLQGLRS-KWEALNRKMTERGDELQQAGQQEQLLRQ 1392
Query: 2747 LDDKQSQQAKNCPISAKLERLQSQLQENEEFQ--KSLNQHSGSYEVIVAEGESL------ 2798
L D + Q LE+L+ LQ +E Q +S + ++ + +E +L
Sbjct: 1393 LQDAKEQ----------LEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAA 1442
Query: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW-HVEDL-VPW 2856
L S+ G L E + H L R + +Q+ H+ ++ + W
Sbjct: 1443 LASMAHGMAASPAI--LEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW 1500
Query: 2857 IEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED 2916
+ + S T +S + K + EV+ + ++ + S+ L S
Sbjct: 1501 VAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQ 1560
Query: 2917 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNI---EKKVEGAKHQLEI 2973
I ++ Q ++ EL+ + + Q+ FQ+ F ++ E VE + +
Sbjct: 1561 HIVEQC----QELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSS 1616
Query: 2974 FDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEV 3033
D +A + + + K +A QE L ++ L Q L ++ Q V
Sbjct: 1617 RDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--------GPEVPEQQRV 1668
Query: 3034 AQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE---MFSQLADLDDELDGMGAIGRDT 3090
Q+ E + + + +LEG + H +RE + LA G ++G D
Sbjct: 1669 VQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDP 1728
Query: 3091 DSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL 3150
+ F +++ + + A +LE + + +R+ + L +L
Sbjct: 1729 EHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD-LQTAWSEL 1787
Query: 3151 TERGKARQEQL---ELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3207
E +AR L E TL D L T E+A +L V ++ + QL
Sbjct: 1788 WELTQARGHALRDTETTLRVHRDLLEVL------TQVQEKATSLPNNVARDLCGLEAQLR 1841
Query: 3208 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3267
+ ++E V + +LQ++ G +Q ++ + + W L +++ Q
Sbjct: 1842 SHQGLERELVGT-ERQLQELLETA-GRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQ 1899
Query: 3268 RIAQLQEALLHCGKFQDALEPLLSWLA----DTEELIANQKPPSAEYKVVKAQIQEQKLL 3323
R AQL+ A L +F+ A+ SW A D + ++Q+P S K+ Q +L
Sbjct: 1900 RRAQLERARL-LARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELE 1958
Query: 3324 QRLLDDRKATVDMLQAEGGRIAQSAELA---DREKITGQLESLESRWTELLSKAAARQKQ 3380
R + L + ++ Q A LA +++ +L +L+ + ++ A +Q++
Sbjct: 1959 AR---------EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQER 2009
Query: 3381 LEDILVLAKQ----FHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3436
L+ A+Q F + + L+ E L S +G+ +++Q I +H+ + +
Sbjct: 2010 LQ-----AEQQEQLFLRECGRLEEILAAQEVSLKTSA-LGSSVEEVEQLIRKHEVFLKVL 2063
Query: 3437 ENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRK-----AALLD 3491
A D +A + + L +L P + +++ L R +++ + A+LL
Sbjct: 2064 T--AQDKKEAA-LRERLKTLRRPR----VRDRLPILLQRRMRVKELAESRGHALHASLLM 2116
Query: 3492 QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKN 3551
+ + A ED ++ W ++++ + ++D + +L H A E+ ++
Sbjct: 2117 ASFTQAATQAEDWIQA--WAQQLKEPVPPGDLRDKLKPLLK-----HQAFEAEVQAHEEV 2169
Query: 3552 VDQAIKNGQALLKQT---TGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK 3608
+ K G+ALL Q+ GE + ++L G++ + D+ + + LE R +
Sbjct: 2170 MTSVAKKGEALLAQSHPRAGE----VSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL-E 2224
Query: 3609 FQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVS 3668
F + W++E E ++ G E Q ++R +E + + + +S
Sbjct: 2225 FLQRVDLAEAWIQEKEVKMNV-GDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283
Query: 3669 RALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAW 3728
L+L E K++ Q + R + R QQ + A
Sbjct: 2284 DLSLQLKNRDPEEV--KIICQRRSQ-------LNNRWASFHGNLLRYQQQLEGA------ 2328
Query: 3729 VAETKRKLMALGPIRLEQDQTTAQLQVQKAF--SIDIIRHKDSMDELFSHRSEIFGTCGE 3786
+ + + E D T ++Q ++A ++D + +S+ L E+ E
Sbjct: 2329 --------LEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEEL-----E 2375
Query: 3787 EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW-------ETYEELSPWIE 3839
+ +Q + ESL ++ + + E L Q V + W + E +
Sbjct: 2376 REVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH 2435
Query: 3840 ETRALIAQLPSPAIDHEQLRQQQE---------EMRQLRESIAEHKPHIDKLL------- 3883
+ + L A L + ++LR Q + E R++ E E K +D
Sbjct: 2436 QAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLAR 2495
Query: 3884 KIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIE 3943
G QL + + E + ++ ++ L L +A+ ++
Sbjct: 2496 STGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMER 2555
Query: 3944 PMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGR 4003
+ ++L+S PL P E + +K +LE AL+ G
Sbjct: 2556 WLCSKEDSLASEGLWDPLAPME-----PLLWKHKMLEWDLEVQAGKISALEATAR---GL 2607
Query: 4004 SQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIK 4063
QG + A+ + M+ E + +A R + L+ L + F D + ++
Sbjct: 2608 HQGGHPE--AQSALGRCQAMLLRKEALFRQAGTRRHR-LEELRQLQAFLQDSQEVAAWLR 2664
Query: 4064 DTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDG-LHEELEFIRILGADLIFACGETEK 4122
+ + LE +D +++ Q++ + + E D +H++ E R + G
Sbjct: 2665 EKNLVA--LEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQR--EGQRLLQGGHPAS 2720
Query: 4123 PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP 4182
+++ ++E+ W L ++++ KL+ A +A ++ + +++ + +WL+ ++L P
Sbjct: 2721 EAIQERLEELGALWGELQDNSQKKVAKLQKACEA-LRLRRSMEELENWLEPIEVEL-RAP 2778
Query: 4183 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTEL 4242
VG L V + L +E + V ++ + E L Q + +++ + E L
Sbjct: 2779 TVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREG--HCLAQDVEEQARRL 2836
Query: 4243 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4302
+++L E + R+ LE L L F+ A EE M+W+ L AQ V
Sbjct: 2837 LQRFKSLREPLQERRTALEARSLLLKFFRDADEE-MAWVQEKLPLAAAQDYGQSLSAVRH 2895
Query: 4303 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4362
++ +H L++++ +H+A V G +L++ AG A+ + A Q E +
Sbjct: 2896 LQ-EQHQNLESEMSSHEALTRVVLGTGYKLVQ--AGHFAAH---EVAARVQQLEKAMAHL 2949
Query: 4363 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4422
+ + LQQAQ E + FL EL S L+ H+
Sbjct: 2950 RAEAARRRLLLQQAQ----EAQQFLTELLEAGSWLAERG---------------HVLDSE 2990
Query: 4423 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE---QSVALLEQKWHVVSSKMEERKSKL 4479
+ E LL RL RD + E Q+ ALLE + + S K+ + +
Sbjct: 2991 DMGHSAEATQALLR--RLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV 3048
Query: 4480 EEA----LNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQ-----IEEHKVF 4530
EA L A + LQE + L ++L + + + T SQ +E KV
Sbjct: 3049 REAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVL 3108
Query: 4531 ANEVNAHRDQIIELDQTG-NQLKFLSQKQD------VVLIKNLLVSVQSRWEKVVQRSIE 4583
+ +A R ++ L Q L+ L+ + I+ +++ WE++ Q
Sbjct: 3109 EEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKA 3168
Query: 4584 RGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTL 4643
R +L A + F +A +L +++ + + E + + ++ +H+ ++ L
Sbjct: 3169 RTENLAAAHE-VHSFQQAAAELQGRMQEKTALMKGE-DGGHSLSSVRTLQQQHRRLEREL 3226
Query: 4644 GGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 4703
+ R E L + L +V++ W T+ K+ ER L +A
Sbjct: 3227 EAMEK------EVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQ 3280
Query: 4704 FSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVL 4763
F+ Q L+ W + + +LA + + D+ L+ H+ +E+ + Q L
Sbjct: 3281 -GHAFLGRCQELLAWAQERQ-ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDL 3338
Query: 4764 KRSGRELIENSRDDTTWV-------KGQLQELSTRWD---TVCKLSVSKQSRLEQALKQA 4813
++ G++L++NS + V +G+LQEL W C S Q +L Q L+QA
Sbjct: 3339 RQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQ-KLRQRLEQA 3397
Query: 4814 EVF 4816
E +
Sbjct: 3398 EAW 3400
Score = 206 bits (523), Expect = 7e-52
Identities = 688/3493 (19%), Positives = 1348/3493 (38%), Gaps = 431/3493 (12%)
Query: 1398 LTTQHVKYISDALRRLEEEEKVVE-EEKQEHVEKVKELLGWVSTLARNTQGKATSSETKE 1456
L TQ+ + ++D LR + E++ +E + + + +++LL T+ R TQ K
Sbjct: 272 LQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLA-AFTIFR-TQEKPPR----- 324
Query: 1457 STDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNK 1516
L+Q+ +E L + + +A + + FL G L+E L++
Sbjct: 325 --------LQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAE------------LSQ 363
Query: 1517 AYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGR 1576
+ L A + Q LQ +L +TL ++ E S++ AE+ L Q R
Sbjct: 364 CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRE---SFLKDAEQVL--DQAR 418
Query: 1577 TTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKL 1636
L+ ++ L L+ I + F + + + +E + + +
Sbjct: 419 APPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWAD-----VARRQ 473
Query: 1637 HQAKEQYEALQEETRVAQKELEE--AVTSALQQETEKSKAAKELAENKKKIDALLDWVTS 1694
+ +++ L + + +K++ + AV S LQ+ S +EL E + T+
Sbjct: 474 EEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARS--------TA 525
Query: 1695 VGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLS 1754
G +++ L + L GA + + L E+++A+ + L
Sbjct: 526 CGQQLAEVVELLQRHDLLEAQVSAHGA-HVSHLAQQTAELDSSLGTSVEVLQAKARTLAQ 584
Query: 1755 QQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ 1814
QQ+ + ++ +A L+Q T + + L+ E +E + Q + L
Sbjct: 585 LQQSLVALVRARRALLEQ-----TLQRAEFLRNC--EEEEAWLKECGQRVGNAALGRDLS 637
Query: 1815 DELQKFLQDHKEFESWLERSEKELENMHKGGSS-----PETLPSLLKR----QGSFS--- 1862
++ LQ HK E+ + R + ++ + G P T P +R QG +
Sbjct: 638 -QIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQ 696
Query: 1863 EDVISHKGDLRFVTISGQKVLDMENS---FKEGKEPSEIGNLVKDKLKDATERYTALHSK 1919
V+ L+ + Q D + +E + E + +D+ A E H +
Sbjct: 697 TRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQA--AAETLLRRHVR 754
Query: 1920 CTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQ 1979
R+ F L+ +A A ++ S PG E L
Sbjct: 755 LERV----------LRAFAAELRRLEEQGRAASARASLFTVNSALSPPG---ESLRNPGP 801
Query: 1980 LQEELAEHQVPVEKLQKVARDIMEIEGEPAPDH--RHVQETTDSILSHFQSLSYSLAERS 2037
E H P + + M + EP PD + +T D + ++SL R
Sbjct: 802 WSEASC-HPGPGDAWK------MALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRR 854
Query: 2038 SLLQKAIA------QSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKL 2091
+ L++A+A +Q LE + V+ + +V L ALA L
Sbjct: 855 ARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGL 914
Query: 2092 KQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKK 2151
+++ SS E R+ +ST +Q + E+SQR+ QL ++EK L
Sbjct: 915 WAEVS---SSAEQLRQRYP-----GNSTQ---IQRQQEELSQRWGQLEALKREKAVQLAH 963
Query: 2152 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL 2211
+ + Q + ++ A +D H Q Q+ L +E + L
Sbjct: 964 SVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLE---RRVHFL 1020
Query: 2212 EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRT 2271
+ +V ++ G+A + Q +V+ L+ ++Q+ V +R + + Q + F + +
Sbjct: 1021 QSVVVKVEEPGYA-ESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQAR-QSFLQESQQ 1078
Query: 2272 FQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIM 2331
W + + + E S+ ++ + + LL++ +++++ + + L
Sbjct: 1079 LLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAAL-- 1136
Query: 2332 EITAPDSQG--KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHER 2389
PDSQ T +L G + K L E + L+ +K G +
Sbjct: 1137 --DCPDSQEVPNTLRVLGQQGQEL---------KVLWEQRQQWLQEGLELQKFGREVDGF 1185
Query: 2390 QESL---QAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2446
+ QA L+ ++ + ++ L L+ E + + + + E ++A E
Sbjct: 1186 TATCANHQAWLH-LDNLGEDVREALSLLQQHREFGRLLSTLGP--RAEALRAHGEKL--- 1239
Query: 2447 LAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLE 2506
++ P V+E L + + ++W R + R+RQL
Sbjct: 1240 ---VQSQHPAAHTVREQL--------------------QSIQAQWTRLQGRSEQRRRQLL 1276
Query: 2507 ESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ 2566
S L ++ ++L W+ EK LM P N+L K+ + E A R+
Sbjct: 1277 ASLQ-LQEWKQDVAELMQWMEEKGLM-AAHEPSGARRNILQTLKRH-EAAESELLATRRH 1333
Query: 2567 HEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQY 2626
E L + + +L+ +Q LQ + KW L K+ R ++ QA Q
Sbjct: 1334 VEALQQVGRELLSRR---PCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQA----GQQ 1386
Query: 2627 QELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCD 2686
++LL+ L + + Q ++ A+ Q Q L + ++ +QL+ E++TL
Sbjct: 1387 EQLLRQLQDAKEQLEQ---LEGAL--QSSETGQDLRSSQRLQKRHQQLE---SESRTLAA 1438
Query: 2687 ELSVLIGEQY-------LKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQM 2739
+++ L + + +E +K L + L L+ A R +LQA++ QF +
Sbjct: 1439 KMAALASMAHGMAASPAILEETQKHLRRLEL----LQGHLAIRGLQLQASV-ELHQFCHL 1493
Query: 2740 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL 2799
+ +W+ + + L QS ++++E Q + H G + +++ G SL
Sbjct: 1494 SNMELSWVAEHMPHGSPTSYTEC-LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLA 1552
Query: 2800 LSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA---QKYQWHVEDLVPW 2856
S P + + + Q EL+ HW EL + R C+Q+A Q+Y V +L W
Sbjct: 1553 ASGHP--QAQHIVEQCQELEGHWAELERACEARAQ----CLQQAVTFQQYFLDVSELEGW 1606
Query: 2857 IEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED 2916
+E+ + +S D + + +A+ E+ S +E L+ A L ++
Sbjct: 1607 VEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQ 1666
Query: 2917 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDA 2976
+ E+ + + + A+ +EL A E T RL EF ++++ + K + ++
Sbjct: 1667 RVVQER--LREQLRAL-QELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGES 1723
Query: 2977 LGSQACSNKNL-EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD-GSDASQLLHQAEVA 3034
LG +L K Q ++ +V R + L+E G Q + A
Sbjct: 1724 LGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTA 1783
Query: 3035 QQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQ 3094
E E+ Q E L + H + E+ +Q+ + L + RD L+
Sbjct: 1784 WSELWELTQARGHALRDTETTL----RVHRDLLEVLTQVQEKATSLPNN--VARDLCGLE 1837
Query: 3095 SQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERG 3154
+Q L L+ ++ +E + + +LE G + L + A+ ++ +T+
Sbjct: 1838 AQ-------LRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAW 1890
Query: 3155 ---KARQEQLELTLGRVEDFYRKLKGLND-ATTAAEEAEALQWVVGTEVEIINQQLADFK 3210
+ R EQ L R R + D A+ AA + LQ ++
Sbjct: 1891 AVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAH 1950
Query: 3211 MFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDC-----DVQGLEHDMEEINARWNTLNKKV 3265
+ + +++ + QQ LGQ + +AG +++ L+ +++ W +++
Sbjct: 1951 QWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERL 2010
Query: 3266 AQRIAQLQEALLHCGKFQDAL---------EPLLSWLADTEELIANQ----KPPSAEYKV 3312
Q Q Q L CG+ ++ L L S + + E+LI K +A+ K
Sbjct: 2011 -QAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKK 2069
Query: 3313 VKAQIQEQKLLQR---------LLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESL 3363
A + K L+R LL R ++ ++ G + S +A + Q E
Sbjct: 2070 EAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDW 2129
Query: 3364 ESRWTELLSKAAARQKQLEDILVLAKQ--FHETAEPISDFLSVTEKK----LANSEPVGT 3417
W + L + + + L K F + + ++ KK LA S P
Sbjct: 2130 IQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAG 2189
Query: 3418 QTAKIQQQIIRH----------KALEEDIENHATDVHQAVKIGQS-LSSLTSPAEQGVLS 3466
+ ++ Q + +H + E + + + Q V + ++ + G L
Sbjct: 2190 EVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLG 2249
Query: 3467 EKID---SLQARYSEIQ---------DRCCRKAALLDQALSNARLFGEDEVEVLNWLAEV 3514
+ ++ L+ R E + D C R + L L N +EV+++ +
Sbjct: 2250 QDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR---DPEEVKII---CQR 2303
Query: 3515 EDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRK-KNVDQAIKNGQALLKQTT-GEEVL 3572
+L++ + F ++L Q AL +++R+ NV + I+ +AL++ G+++
Sbjct: 2304 RSQLNNRWAS-FHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLE 2362
Query: 3573 LIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGG 3632
+Q L + ++ ++ + +LE R++ Q + E G LR ++E+A S
Sbjct: 2363 SVQRLLRKHEELEREVHPIQAQ-VESLE--REVGRLCQRSPEAAHG-LRHRQQEVAESWW 2418
Query: 3633 Q-----SPTGEQIPQFQQRQK------ELKKEVMEHRLVLDT-------------VNEVS 3668
Q E + Q QK EL R +DT + E
Sbjct: 2419 QLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQ 2478
Query: 3669 RALLELVPWR-----AREGLDKLVSDAN---EQYKLVSDTIGQRVDEIDAAIQRSQ-QYE 3719
EL W AR +L++ + + V + Q + ++ A Q Q Q +
Sbjct: 2479 ECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQ 2538
Query: 3720 QAADAEL---------AWVAETKRKLMALG---------PIRLEQDQTTAQLQVQKAFSI 3761
QA + +L W+ + L + G P+ + L+VQ
Sbjct: 2539 QALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAG--- 2595
Query: 3762 DIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQ 3821
K S E + R G E Q + + ++++ + EA+ R RLE +
Sbjct: 2596 -----KISALEATA-RGLHQGGHPEAQSAL--GRCQAMLLRKEALFRQAGTRRHRLEELR 2647
Query: 3822 VLVNQFWETYEELSPWIEETR--ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHI 3879
L F + +E++ W+ E AL L A+ QL++QQ +L S+ + +
Sbjct: 2648 QL-QAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQ--- 2703
Query: 3880 DKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFH 3939
+L + G +L + E ++E+ ++ ++ ++++ +++ L +A ++ ++
Sbjct: 2704 -ELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRLRRSM 2761
Query: 3940 DKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEE 3999
+++E LE +E LR P + A + + E + + +L+ + + R+ E
Sbjct: 2762 EELENWLEPIE---VELRAPTVGQA-LPGVGELLGTQR-------ELEAAVDKKARQAEA 2810
Query: 4000 LIGRSQGADKD--LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAA 4057
L+G++Q ++ A++++++ +++ ++ ++ +ER L+ L KF+ D
Sbjct: 2811 LLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA-LEARSLLLKFFRDADE 2869
Query: 4058 LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC 4117
+ +++ + + G S ++ E + ++ E HE L + + +
Sbjct: 2870 EMAWVQEKLPLAA-AQDYGQSLSAVRHLQEQHQNLESEMSS-HEALTRVVLGTGYKLVQA 2927
Query: 4118 GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIK 4177
G EV + ++ A +L R L+ A Q A Q+ L WL
Sbjct: 2928 GHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQA-QEAQQFLTELLEAGSWLAERGHV 2986
Query: 4178 LCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIRE 4237
L + +G + L ++ K ++ +E+L L+ + E+ + + +
Sbjct: 2987 LDS-EDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQ- 3044
Query: 4238 PLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGD 4297
L ++ L + R H L+ L L Q + L +WLT ++Q D
Sbjct: 3045 -LQAVREAHAELLRRAEARGHGLQEQL-QLHQLERETLLLDAWLTTKAATAESQ-DYGQD 3101
Query: 4298 PKVIEVELAKHHVLKNDVLA-HQATVETVNKAGNELLESSAG--DDASSLRSRLEAMNQC 4354
+ ++V K + +V + QA V + K L + + RSR+EA
Sbjct: 3102 LEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEA---A 3158
Query: 4355 WESVLQKTEEREQQLQST--LQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETARE 4412
WE + Q + R + L + + Q +E++ + E T L + G + R
Sbjct: 3159 WERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTA----LMKGEDGGHSLSSVRT 3214
Query: 4413 QLDTHMELYSQLKAKEETYNQLLDKG-RLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSK 4471
H L +L+A E+ +L + RL L G +K +++ W + +K
Sbjct: 3215 LQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEA-------WATLQAK 3267
Query: 4472 MEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQ--IEEHKV 4529
+ER L +A F QE + W A++ +AS L + ++ + +H+
Sbjct: 3268 AQERGQWLAQAAQ-GHAFLGRCQELLAW---AQERQELASSEELAEDVAGAEQLLGQHEE 3323
Query: 4530 FANEVNAHRDQIIELDQTGNQL----KFLSQKQDVVL--IKNLLVSVQSRWEKVVQRSIE 4583
E+ R Q +L Q G QL F+S + L ++ L ++ W QR E
Sbjct: 3324 LGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAE 3383
Query: 4584 RG--RSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEF-- 4639
+ L ++A+ + W+ L+ + S D EL + D KL ++ ++F
Sbjct: 3384 SWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQ 3443
Query: 4640 -QKTLGGK----QPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
QKT + QP R G +L P Q L L E RD D ++E
Sbjct: 3444 MQKTEMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQGLGAQLAETRDPQDAKGTPTMEG 3503
Query: 4695 QHKLEEALLFSGQ 4707
+ ++ LL G+
Sbjct: 3504 SLEFKQHLLPGGR 3516
Score = 158 bits (399), Expect = 2e-37
Identities = 338/1660 (20%), Positives = 649/1660 (39%), Gaps = 190/1660 (11%)
Query: 3260 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE-ELIANQKPPS--------AEY 3310
T+ +++ + + QLQE L +++ + LL W+A+ + +L A P S A +
Sbjct: 254 TVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAF 313
Query: 3311 KVVKAQIQEQKLLQR----LLDDRKATVDMLQAEGGRIAQSAE---LADREKITGQLESL 3363
+ + Q + +L QR L R T LQA+ R E LA+ + LE
Sbjct: 314 TIFRTQEKPPRLQQRGAAEALLFRLQTA--LQAQNRRPFLPHEGLGLAELSQCWAGLE-- 369
Query: 3364 ESRWTELLSKAAARQK--QLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAK 3421
W E A +Q+ QL+ + LA++F A FL E+ L + A
Sbjct: 370 ---WAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLAT 426
Query: 3422 IQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQD 3481
++ + R LE I + Q + Q+L+ + Q D + R E+
Sbjct: 427 VEAAVQRLGMLEAGI------LPQEGRF-QALAEIADILRQEQYHSWAD-VARRQEEVTV 478
Query: 3482 RCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLAL 3541
R R L Q L R D VL+ L EVE +S +++ ++ LA
Sbjct: 479 RWQR----LLQHLQGQRKQVADMQAVLSLLQEVE--AASHQLEELQEPARSTACGQQLAE 532
Query: 3542 NEEIVNRKKNVDQAIK----------NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVT 3591
E++ R ++ + A L + G V ++Q K + +
Sbjct: 533 VVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVAL 592
Query: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQ---QRQK 3648
LEQ Q A +F EE WL+E + + G + G + Q Q+ K
Sbjct: 593 VRARRALLEQTLQRA-EFLRNCEEEEAWLKECGQRV----GNAALGRDLSQIAGALQKHK 647
Query: 3649 ELKKEVMEHRLV-LDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 3707
L+ EV H+ V +D V P + G + ++L+ + R
Sbjct: 648 ALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG--ERAEAVQGGWQLLQTRVVGRGAR 705
Query: 3708 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQL---------QVQKA 3758
+ A+ Q + AA+A +W+ E + L QDQ A+ +V +A
Sbjct: 706 LQTALLVLQYFADAAEA-ASWLRERRSSLERAS---CGQDQAAAETLLRRHVRLERVLRA 761
Query: 3759 FSIDIIRHKDSMDELFSHRSEIF----------------GTCGE---------------- 3786
F+ + +R + S R+ +F G E
Sbjct: 762 FAAE-LRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALP 820
Query: 3787 -------EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIE 3839
+ T+LQ + + L Q YE++ L R ARLE A L F + EL W+E
Sbjct: 821 AEPDPDFDPNTILQTQ-DHLSQDYESLRALAQLRRARLEEAMALFG-FCSSCGELQLWLE 878
Query: 3840 ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM 3899
+ L+ ++ A + L Q + ++A K ++ QL++ P
Sbjct: 879 KQTVLLQRVQPQA---DTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ 935
Query: 3900 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 3959
++ + ++ + Q++ R++A+ L + S ++ F + P L ++ L++
Sbjct: 936 IQRQQEELSQRWGQLEALKREKAVQL----AHSVEVCSFLQECGPTQVQLRDV--LLQLE 989
Query: 3960 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4019
L P + + + T+ LE+ +++ + EE G ++ + +Q
Sbjct: 990 ALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEE-PGYAESQPLQGQVETLQGL 1048
Query: 4020 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4079
L Q+ E + RA + + + F + LL + Q + E
Sbjct: 1049 LKQV---QEQVAQRARRQA-----ETQARQSFLQESQQLLLWAESVQAQLRSKE------ 1094
Query: 4080 SIIKQQVEAAETIKEETDGLHEEL----EFIRILGADL--IFACGETEKPEVRKSIDEMN 4133
+ V +A+ + E L EE+ E ++ L A + A + EV ++ +
Sbjct: 1095 --VSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLG 1152
Query: 4134 NAWENLNKTWKERLEKLEDAMQ------AAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTD 4187
+ L W++R + L++ ++ + T WL + +G D
Sbjct: 1153 QQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLH--------LDNLGED 1204
Query: 4188 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4247
+ L + +EF + E L GE +++ + +RE L ++ W
Sbjct: 1205 VREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQ--SQHPAAHTVREQLQSIQAQWT 1262
Query: 4248 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAK 4307
L + R+ +L A L L +++ + ELM W+ + L+ A P SG + I L +
Sbjct: 1263 RLQGRSEQRRRQLL-ASLQLQEWKQDVAELMQWM-EEKGLMAAHEP-SGARRNILQTLKR 1319
Query: 4308 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQ 4367
H ++++LA + VE + + G ELL S +++RL+ + WE++ +K ER
Sbjct: 1320 HEAAESELLATRRHVEALQQVGRELL-SRRPCGQEDIQTRLQGLRSKWEALNRKMTERGD 1378
Query: 4368 QLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAK 4427
+LQ QQ Q +++D +L ++E L +S+ L + R Q + + QL+++
Sbjct: 1379 ELQQAGQQEQ-LLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQ-----KRHQQLESE 1432
Query: 4428 EETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLAT 4487
T + L ++ + S + E++ L ++ ++ + R +L+ ++ L
Sbjct: 1433 SRTLAAKM--AALASMAHGMAASPAILEETQKHL-RRLELLQGHLAIRGLQLQASVEL-H 1488
Query: 4488 EFQNSLQEFINWLTLAEQSLNIASPPSL--ILNTVLSQIEEHKVFANEVNAHRDQIIELD 4545
+F + ++W+ + + SP S LN S +HK EV AH+ Q+ +
Sbjct: 1489 QFCHLSNMELSWVA---EHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVL 1545
Query: 4546 QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKL 4605
+G L Q +++ ++ W ++ + R + L A + F + +L
Sbjct: 1546 SSGRSLAASGHPQAQHIVEQ-CQELEGHWAELERACEARAQCLQQAVTFQQYFLDV-SEL 1603
Query: 4606 IDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTL 4665
W+E+ + L S + D ++KH+ Q+ L +Y +++ +
Sbjct: 1604 EGWVEE-KRPLVSSRDYGRDEAATLRLINKHQALQEELA----IYWSSMEELDQTAQTLT 1658
Query: 4666 LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQ 4725
PE ++ +R++ + + R +LE L +F+ + L WL +
Sbjct: 1659 GPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLH-EFLREAEDLQGWLASQKQA 1717
Query: 4726 LAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 4785
+ + D + ++L FQ ++ + V + L+E V+ +
Sbjct: 1718 AKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQ 1777
Query: 4786 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 4825
Q+L T W + +L+ ++ L V RD + +L +
Sbjct: 1778 QDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ 1817
Score = 157 bits (396), Expect = 4e-37
Identities = 402/1996 (20%), Positives = 771/1996 (38%), Gaps = 224/1996 (11%)
Query: 3188 AEALQWVVGTEVEI-----------INQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ 3236
A+ L+W+ ++++ + Q LA F +F+ ++ P +LQQ G + L+
Sbjct: 281 ADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPP---RLQQ-RGAAEALLF 336
Query: 3237 SAGKDCDVQG----LEHD---MEEINARWNTL-------NKKVAQRIAQLQEALLHCGKF 3282
Q L H+ + E++ W L ++ + QR+ QLQ +F
Sbjct: 337 RLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRF 396
Query: 3283 QDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGG 3342
Q S+L D E+++ + P A V+A +Q +L+ + ++ L AE
Sbjct: 397 QHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQAL-AEIA 455
Query: 3343 RIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFL 3402
I + + + + E + RW LL ++KQ+ D+ + E
Sbjct: 456 DILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLE 515
Query: 3403 SVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDV-HQAVKIGQSLSSLTSPAE 3461
+ E A S G Q A++ + + RH LE + H V H A + + SSL + E
Sbjct: 516 ELQEP--ARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVE 573
Query: 3462 QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV 3521
VL K +L + + ALL+Q L A E E WL E ++ +
Sbjct: 574 --VLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEA-WLKECGQRVGNA 630
Query: 3522 FV-KDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL------LKQTTGEEVLLI 3574
+ +D Q Q H AL E+ + ++ G+ L + GE +
Sbjct: 631 ALGRDLSQIAGALQK--HKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAV 688
Query: 3575 QEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL--ATSGG 3632
Q ++TR AL L+ A E WLRE L A+ G
Sbjct: 689 QGGWQLLQTRVVGRGARLQTALLVLQYFADAA--------EAASWLRERRSSLERASCGQ 740
Query: 3633 QSPTGEQIPQ-------------FQQRQKELKKEVMEHRLVLDTVNEV----SRALLELV 3675
E + + + R+ E + R L TVN +L
Sbjct: 741 DQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPG 800
Query: 3676 PWRARE------GLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV 3729
PW K+ A +TI Q D + + + Q A L
Sbjct: 801 PWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEA 860
Query: 3730 AETKRKLMALGPIRLEQDQTTAQLQ-VQ-KAFSIDI--IRHKDSMDELFSHR---SEIFG 3782
+ G ++L ++ T LQ VQ +A ++++ +++++ + L + +E+
Sbjct: 861 MALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSS 920
Query: 3783 TCGEEQK------TVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 3836
+ + ++ T +Q + E L Q++ + L E+ +L + V V F +E P
Sbjct: 921 SAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHS-VEVCSF---LQECGP 976
Query: 3837 WIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 3896
+ R ++ QL + + ++ Q + + E + H L + +++E E
Sbjct: 977 TQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHF--LQSVVVKVEEPGYAE 1034
Query: 3897 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 3956
+ ++ + + + + Q++E+V QRA +A +Q+ Q F + + +L E++ ++L
Sbjct: 1035 SQPLQGQVETLQGLLKQVQEQVAQRARR--QAETQARQ--SFLQESQQLLLWAESVQAQL 1090
Query: 3957 RMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLA-AKE 4015
R + +V + + +++ E+ Q + L + + + A D ++E
Sbjct: 1091 RSKE-VSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPM------AALDCPDSQE 1143
Query: 4016 IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP 4075
+ + L + +++K E+R+ + LEL +KF ++ T + Q +H L++
Sbjct: 1144 VPNTLRVLGQQGQELKVLWEQRQQWLQEGLEL-QKFGREVDGFTATCANHQAWLH-LDNL 1201
Query: 4076 GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILG-----ADLIFACGE----TEKPE-- 4124
G E ++E L + EF R+L A+ + A GE ++ P
Sbjct: 1202 G-------------EDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAH 1248
Query: 4125 -VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4183
VR+ + + W L ++R +L ++Q QD + M W++ + + P
Sbjct: 1249 TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELM-QWMEEKGL-MAAHEP 1306
Query: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQG-ELMLKKATDETDRDIIREPLTEL 4242
G N ++ L + + E+ + +E L G EL+ ++ + D I+ L L
Sbjct: 1307 SGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQED---IQTRLQGL 1362
Query: 4243 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA-QRPISGDPKVI 4301
+ WE L K+ R +L+ A GQ + L +L E+L A Q +G
Sbjct: 1363 RSKWEALNRKMTERGDELQQA----GQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
Query: 4302 EVELAKHHV-LKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQ 4360
L K H L+++ A + + + + S A + + R + Q ++
Sbjct: 1419 SQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAI-- 1476
Query: 4361 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD----- 4415
R QLQ++++ Q H L+ ME A G P + E L+
Sbjct: 1477 ----RGLQLQASVELHQFCH---------LSNMELSWVAEHMPHGSPTSYTECLNGAQSL 1523
Query: 4416 --THMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVAL----LEQKWHVVS 4469
H EL ++KA + ++L GR + + SG Q + LE W +
Sbjct: 1524 HRKHKELQVEVKAHQGQVQRVLSSGRSL------AASGHPQAQHIVEQCQELEGHWAELE 1577
Query: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN--TVLSQIEEH 4527
E R L++A+ F + + E W+ E+ + S + L I +H
Sbjct: 1578 RACEARAQCLQQAVTFQQYFLD-VSELEGWV---EEKRPLVSSRDYGRDEAATLRLINKH 1633
Query: 4528 KVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRS 4587
+ E+ + + ELDQT L + +++ L + + + + + R R
Sbjct: 1634 QALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERL---REQLRALQELAATRDRE 1690
Query: 4588 LDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG-GK 4646
L+ + + EA + L WL + + DP+ +K +FQ + G
Sbjct: 1691 LEGTLRLHEFLREA-EDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGS 1749
Query: 4647 QPVYDTTIRTGRALKE-KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFS 4705
Q V + L+ + P Q+ +++ W + + R H L +
Sbjct: 1750 QRVAACRLLAESLLERGHSAGPMVRQRQQ----DLQTAWSELWELTQARGHALRDTETTL 1805
Query: 4706 GQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKEL-GKRTGTVQVLK 4764
D L+ L E + V DL + + +H+ ++EL G ++L+
Sbjct: 1806 RVHRDLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLE 1862
Query: 4765 RSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLL 4824
+GR V+ + Q ++ W + + ++++LE+A A FR V
Sbjct: 1863 TAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLAR-FRTAVRDYA 1921
Query: 4825 EWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHP 4884
W + Q L+ + + + L H+ ++E + A +G+ L
Sbjct: 1922 SWAARVRQDLQVEESSQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGT 1980
Query: 4885 DCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAEL--LEELLAWIQWAETT 4942
+ + R + TWA++ Q+RL+ E + E LEE+LA + + T
Sbjct: 1981 PTKEVQEELRALQDQRDQVYQTWARK-QERLQAEQQEQLFLRECGRLEEILAAQEVSLKT 2039
Query: 4943 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMT---RKQPDVDRVTKTYKRKNIEPTHAPFI 4999
+ +++ V+ LI +H+ F++ +T +K+ + KT +R + P +
Sbjct: 2040 ------SALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRD-RLPIL 2092
Query: 5000 EKSRSGGRK---SLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDAL 5056
+ R ++ S + + S ++A + W Q W L+ D
Sbjct: 2093 LQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQAWAQQLKEPVPPGDLR 2147
Query: 5057 DRLEELKEFANFDFDV 5072
D+L+ L + F+ +V
Sbjct: 2148 DKLKPLLKHQAFEAEV 2163
Score = 144 bits (363), Expect = 2e-33
Identities = 378/1897 (19%), Positives = 746/1897 (39%), Gaps = 238/1897 (12%)
Query: 3241 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3300
D D + + ++ + +L R A+L+EA+ G F + L WL L+
Sbjct: 826 DFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFG-FCSSCGELQLWLEKQTVLL 884
Query: 3301 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAEL------ADRE 3354
+P + +V+ Q++ + L L A L AE ++ SAE +
Sbjct: 885 QRVQPQADTLEVM--QLKYENFLTAL-----AVGKGLWAE---VSSSAEQLRQRYPGNST 934
Query: 3355 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP 3414
+I Q E L RW +L + + QL + + F + P L +L +P
Sbjct: 935 QIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCS-FLQECGPTQVQLRDVLLQLEALQP 993
Query: 3415 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQA 3474
++ Q+ + K L + H VK+ + AE L ++++LQ
Sbjct: 994 GSSEDTCHALQLAQKKTLVLERRVHFLQ-SVVVKVEEP-----GYAESQPLQGQVETLQG 1047
Query: 3475 RYSEIQDRCCRKAALLDQALSNARL-FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHR 3533
++Q++ ++A QA + AR F ++ ++L W V+ +L
Sbjct: 1048 LLKQVQEQVAQRARR--QAETQARQSFLQESQQLLLWAESVQAQL--------------- 1090
Query: 3534 QHADHLALNEEIVNRKKNVDQAIKNGQALLK--QTTGEEVLLIQEKLDGIKTRYADITVT 3591
R K V + + Q LL+ Q EE+ L QE+L + + +
Sbjct: 1091 --------------RSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAAL 1136
Query: 3592 ----SSKALRTLEQARQLATKFQSTYEELTGWL----------REVEEELATSGGQSPTG 3637
S + TL Q + + +E+ WL REV+ AT
Sbjct: 1137 DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANH---- 1192
Query: 3638 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRA---REGLDKLVSDANEQY 3694
Q L ++V E +L E R L L P RA R +KLV +
Sbjct: 1193 ----QAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGP-RAEALRAHGEKLVQSQHPAA 1247
Query: 3695 KLVSDTIG--------------QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALG 3740
V + + QR ++ A++Q Q+++Q + W+ E K + A
Sbjct: 1248 HTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQL-QEWKQDVAELMQWMEE-KGLMAAHE 1305
Query: 3741 PIRLEQD--QTTAQLQVQKAFSIDIIRHKDSMD----ELFSHRSEIFGTCGEEQKTVLQE 3794
P ++ QT + + ++ + RH +++ EL S R CG+E +Q
Sbjct: 1306 PSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRP-----CGQED---IQT 1357
Query: 3795 KTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAID 3854
+ + L ++EA++ +ER L++A E+L +++ + + QL
Sbjct: 1358 RLQGLRSKWEALNRKMTERGDELQQAG--------QQEQLLRQLQDAKEQLEQLEGALQS 1409
Query: 3855 HE---QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMY 3911
E LR Q ++ ++ +E + K+ + + + E+ QK
Sbjct: 1410 SETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA--ILEETQKHLRRL 1467
Query: 3912 AQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE 3971
++ + R L L +V E H L +E MP P E
Sbjct: 1468 ELLQGHLAIRGLQLQASV-------ELHQFCH--LSNMELSWVAEHMPHGSPTSYT---E 1515
Query: 3972 CISDNKSATVELEKLQPSFEALKRRGEELI--GRSQGADKDLAAKEIQDKLDQMVFFWED 4029
C++ +S + ++LQ +A + + + ++ GRS A A+ I ++ ++ W +
Sbjct: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAE 1575
Query: 4030 IKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAA 4089
++ RA E + L ++++ D++ L +++ + +V + G D + + +
Sbjct: 1576 LE-RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY-GRDEAATLRLINKH 1633
Query: 4090 ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLE- 4148
+ ++EE +E + L ++ V++ + E A + L T LE
Sbjct: 1634 QALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDRELEG 1693
Query: 4149 --KLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVY 4206
+L + ++ A Q WL + +G D + +F+ +V
Sbjct: 1694 TLRLHEFLREAEDLQG-------WLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVE 1746
Query: 4207 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4266
+ E +L++ + ++R+ +L+ W L E R H L
Sbjct: 1747 MGSQRVAACRLLAESLLERG--HSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETT 1804
Query: 4267 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326
L + LE L E+ ++ D +E +L H L+ +++ + ++ +
Sbjct: 1805 LRVHRDLLEVLTQV---QEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861
Query: 4327 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4386
+ + + G A +++ R +A+ Q W + ++ E+R QL+ A+ F + + D+
Sbjct: 1862 ETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLAR-FRTAVRDY 1920
Query: 4387 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4446
R+ L + + P + +L H L ++L+A+E+ + Q G+ LL+
Sbjct: 1921 ASWAARVRQDLQVEE-SSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-- 1977
Query: 4447 DSGSGSK--TEQSVALLEQKWHVVSS---KMEERKSKLEEALNLATEFQNSLQEFINWLT 4501
+G+ +K E+ AL +Q+ V + K E +++ +E L F L
Sbjct: 1978 -AGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQL-----FLRECGRLEEILA 2031
Query: 4502 LAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVV 4561
E SL ++ S + V I +H+VF + A + L + +LK L + +
Sbjct: 2032 AQEVSLKTSALGSSV-EEVEQLIRKHEVFLKVLTAQDKKEAALRE---RLKTLRRPR--- 2084
Query: 4562 LIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE 4621
+++ L + R +V + + RG +L + A F +A + DW++ L +
Sbjct: 2085 -VRDRLPILLQRRMRVKELAESRGHALHASLLMA-SFTQAATQAEDWIQAWAQQLKEPVP 2142
Query: 4622 ISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--KEKTLLPEDSQKLDNFLGE 4679
+ DK+K L KH+ F+ + + V + + G AL + E SQ+L
Sbjct: 2143 PGDLRDKLK-PLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQG---- 2197
Query: 4680 VRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLV 4739
+R W+ + R +LE+ F +F+ + W+ + E ++ + DL+
Sbjct: 2198 LRKHWEDLRQAMALRGQELEDRRNFL-EFLQRVDLAEAWIQEKEVKMNVGD-LGQDLEHC 2255
Query: 4740 MNLMDAHKVFQ-KELGKRTGTVQVLKRSGRELIENSRD--DTTWVKGQLQELSTRWDTVC 4796
+ L + F+ G G + S L +RD + + + +L+ RW +
Sbjct: 2256 LQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFH 2315
Query: 4797 KLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL------PDDTEALQSL 4850
+ Q +LE AL+ +H+L L + ++ + AL D E++Q L
Sbjct: 2316 GNLLRYQQQLEGALE--------IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRL 2367
Query: 4851 IDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCH--PDCITTIKHWITIIRARFEEVLTWA 4908
+ H+E ++V + V S + + +C P+ ++H + + ++ + A
Sbjct: 2368 LRKHEELEREVHPIQAQVES---LEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRA 2424
Query: 4909 KQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTF 4968
++ ++ L+ AL + +L+ELL A+ Q D P P++ + ++ EHQ
Sbjct: 2425 QKRREALD-ALHQAQKLQAMLQELLV---SAQRLRAQMDTSPAPRSPVEARRMLEEHQEC 2480
Query: 4969 MEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKN 5028
E+ D T + I +RS G++ L+ P I
Sbjct: 2481 KAEL-------DSWTDS-------------ISLARSTGQQLLTAGHPFSSDIRQVLAGLE 2520
Query: 5029 PRINQLSARWQQVWLLALERQRKLNDALDRLEELKEF 5065
++ L WQ+ L L++ +L L +E+++ +
Sbjct: 2521 QELSSLEGAWQE-HQLQLQQALELQLFLSSVEKMERW 2556
Score = 79.7 bits (195), Expect = 7e-14
Identities = 264/1272 (20%), Positives = 486/1272 (38%), Gaps = 175/1272 (13%)
Query: 3798 SLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIA--QLPSPAIDH 3855
S + Q + + ++ +L+ ++L Q+ + +L WI E + + P
Sbjct: 247 SRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAM 306
Query: 3856 EQL-------RQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN-----PEEGEMVEEK 3903
QL R Q++ R + AE L ++ L+ N P EG + E
Sbjct: 307 RQLLAAFTIFRTQEKPPRLQQRGAAEAL-----LFRLQTALQAQNRRPFLPHEGLGLAEL 361
Query: 3904 YQ---KAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPP 3960
Q E A + ++QR L L + + + E L+ E + + R PP
Sbjct: 362 SQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPP 421
Query: 3961 LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKL 4020
ATVE A++R G G + A EI D L
Sbjct: 422 A---------------SLATVEA--------AVQRLGMLEAGILPQEGRFQALAEIADIL 458
Query: 4021 DQMVFF-WEDIKARAEEREIKF---LDVLELAEKFWYDMAALLTTIKDTQDIVHDLES-- 4074
Q + W D+ R EE +++ L L+ K DM A+L+ +++ + H LE
Sbjct: 459 RQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQ 518
Query: 4075 -PGIDPSIIKQQVEAAETIKEETDGLHEELEF-IRILGADLIFACGETEKPE-------- 4124
P + +Q E E ++ H+ LE + GA + +T + +
Sbjct: 519 EPARSTACGQQLAEVVELLQR-----HDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVE 573
Query: 4125 -VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4183
++ + ++L + R LE +Q A ++ + WL ++
Sbjct: 574 VLQAKARTLAQLQQSLVALVRARRALLEQTLQRA-EFLRNCEEEEAWLKECGQRVGNAA- 631
Query: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQG-ELMLKKATDETDRDIIREPLTEL 4242
+G DL+ + L + K + EV++ Q L +G +L ++ + D E +
Sbjct: 632 LGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG---ERAEAV 688
Query: 4243 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4302
+ W+ L ++ R +L+ ALL L F A E SWL L +R G +
Sbjct: 689 QGGWQLLQTRVVGRGARLQTALLVLQYFADA-AEAASWLRERRSSL--ERASCGQDQAAA 745
Query: 4303 VELAKHHVLKNDVL-----------------AHQATVETVNKAGNELLESSAGDDASSLR 4345
L + HV VL + +A++ TVN A + ES S
Sbjct: 746 ETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEA 805
Query: 4346 SRLEAMNQCWE--------------SVLQKTEEREQQLQSTLQQAQGFHSEIED----FL 4387
S W+ ++LQ + Q +S AQ + +E+ F
Sbjct: 806 SCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFG 865
Query: 4388 LELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDD 4447
+ E QL K T L + + Q DT ++ K E + L G+ +
Sbjct: 866 FCSSCGELQLWLEKQT-VLLQRVQPQADT----LEVMQLKYENFLTALAVGKGLWAEVSS 920
Query: 4448 S---------GSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFIN 4498
S G+ ++ ++ L Q+W + + E+ +L ++ + + Q +
Sbjct: 921 SAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQ 980
Query: 4499 WLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAH--RDQIIELDQTGNQLKFLSQ 4556
+ Q L P S Q+ + K E H + ++++++ G Q
Sbjct: 981 LRDVLLQ-LEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQ 1039
Query: 4557 KQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL 4616
Q V ++ LL VQ E+V QR+ R ++ AR + F + ++L+ W E ++ L
Sbjct: 1040 GQ-VETLQGLLKQVQ---EQVAQRA--RRQAETQAR---QSFLQESQQLLLWAESVQAQL 1090
Query: 4617 DSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF 4676
S+ E+S D + L +H++ + + Q + + L DSQ++ N
Sbjct: 1091 RSK-EVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPM--AALDCPDSQEVPNT 1147
Query: 4677 LGEVRDKWDTVCGKSVERQHKLEEALLFS--GQFMDALQALV----DWLYKVEPQLAEDQ 4730
L + + + +RQ L+E L G+ +D A WL+ L E
Sbjct: 1148 LRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL--DNLGE-- 1203
Query: 4731 PVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELST 4790
D+ ++L+ H+ F + L + L+ G +L+++ V+ QLQ +
Sbjct: 1204 ----DVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
Query: 4791 RWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSL 4850
+W + S ++ +L +L Q + ++ V L++W+ E + A + + A +++
Sbjct: 1260 QWTRLQGRSEQRRRQLLASL-QLQEWKQDVAELMQWMEE-----KGLMAAHEPSGARRNI 1313
Query: 4851 IDT---HKEFMKKVEEKRVDVNSAVAMGEVILA--VCHPDCITT-----IKHWITIIRAR 4900
+ T H+ ++ R V + +G +L+ C + I T W + R
Sbjct: 1314 LQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKM 1373
Query: 4901 FEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKA 4960
E + QQ E L +L E LE+L +Q +ET R + + + R +
Sbjct: 1374 TERGDELQQAGQQ--EQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQK---RHQQ 1428
Query: 4961 LIAEHQTFMEEM 4972
L +E +T +M
Sbjct: 1429 LESESRTLAAKM 1440
Score = 51.2 bits (121), Expect = 3e-05
Identities = 301/1593 (18%), Positives = 560/1593 (35%), Gaps = 312/1593 (19%)
Query: 413 LEREKSLRPAVERLELLLQIANKIQNGALNC---------EEKLTLAKNTLQADAAHLES 463
L + LR +E E L Q A ++ AL EE L Q
Sbjct: 1947 LSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARK 2006
Query: 464 GQPVQCESDVIMYIQEC---EGLIRQLQVDLQ-------ILRDENYYQLEELAFRVMRLQ 513
+ +Q E ++++EC E ++ +V L+ + E + E+ +V+ Q
Sbjct: 2007 QERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQ 2066
Query: 514 DEL-VTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSST-SWFRKPMTR 571
D+ LR L R L ++ + L AE A H+S + F + T+
Sbjct: 2067 DKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKEL-AESRGHALHASLLMASFTQAATQ 2125
Query: 572 AELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDL----------PSVELQLET 621
AE W++ +L+ DL + E +++
Sbjct: 2126 AE--------------------DWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA 2165
Query: 622 QQHIHTSVEELGSSV-KEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQ 680
+ + TSV + G ++ ++ G++SQ L L + L++ + R + L+
Sbjct: 2166 HEEVMTSVAKKGEALLAQSHPRAGEVSQR--------LQGLRKHWEDLRQAMALRGQELE 2217
Query: 681 SLH---KFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEK---QD 734
+F+ R W+ EKE + D + + R E
Sbjct: 2218 DRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDA 2277
Query: 735 VFRSLQDTAELLSLENHPAK----------QTVEAYSAAVQSQLQWMKQLCLCVEQHVKE 784
RS+ D + L L+N + Q +++ + L++ +QL +E HV
Sbjct: 2278 CIRSISDLS--LQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVL- 2334
Query: 785 NTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSS 844
+REL++ + +Q+ + D L ++ LL+ + + ++ ++
Sbjct: 2335 ----------SRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQ 2384
Query: 845 VASLVGRSKTIVQLKPRSPD--HVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTK 902
V SL + + +L RSP+ H L+ +RQ E+ L +Q+ +
Sbjct: 2385 VESL---EREVGRLCQRSPEAAHGLR----------HRQQEVA---ESWWQLRSRAQKRR 2428
Query: 903 WKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNY 962
EA+ DA+ A QK+ A+ +L L+S
Sbjct: 2429 ---------EAL-------------DALHQA-------QKLQAMLQEL------LVSAQR 2453
Query: 963 LRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYE--DFLQDSRDSVLFSVADRLRL-- 1018
LR +D S AP + + L+ H E L DS+ + + +L
Sbjct: 2454 LRAQMDT----------SPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLT 2503
Query: 1019 -----EEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQS 1073
++ A + + S+E +E + EL+ +E+ E+ + + S
Sbjct: 2504 AGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDS 2563
Query: 1074 LASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF------LHQS--PSS 1125
LAS W +A E + L DL+ + K + LHQ P +
Sbjct: 2564 LASE----GLWDP----LAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEA 2615
Query: 1126 SSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEV 1185
S + L E + G L +L+ + ++ Q+ ++ E L E
Sbjct: 2616 QSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLR--EKNLVALEE 2673
Query: 1186 VLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERY 1245
L D + L A +++ ++ LD + + + + + RL + E
Sbjct: 2674 GLLDTAMLPAQLQKQQNFQAE----------LDASMHQQQELQREGQRLLQGGHPASEAI 2723
Query: 1246 QEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQ 1305
QE+ +L W + + + ++L+ E L R+ L W+E + GQ
Sbjct: 2724 QERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSME-ELENWLEPIEVELRAPTVGQ 2782
Query: 1306 AEDS--RVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVES 1363
A +L Q + A+ + + + L Q Q F ++ + +D E Q +S
Sbjct: 2783 ALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKS 2842
Query: 1364 QQKSPGKRRRMLSSSDAITQEFMDLRTRYT----ALVTLTTQHVKYISDALRRLEEEEKV 1419
++ +RR L + + + F D L Q A+R L+E+ +
Sbjct: 2843 LREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQN 2902
Query: 1420 VEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAI--LEQQVLSEELTTK 1477
+E E H + +LG L + A + +EKA+ L + L +
Sbjct: 2903 LESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQ-QLEKAMAHLRAEAARRRLLLQ 2961
Query: 1478 KEQVSEAIKTSQI----FLAKHGHKLSEK------------------------------- 1502
+ Q ++ T + +LA+ GH L +
Sbjct: 2962 QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIE 3021
Query: 1503 ---------------EKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA-HQTEQKTL- 1545
E ++ QL A+ +A+ +L + + LQ QL HQ E++TL
Sbjct: 3022 RLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLL 3081
Query: 1546 ----------QKQQNTCHQQLEDL-------------CSWVGQAE----RALAGHQGRTT 1578
+ Q LE + +GQA+ R LAG R
Sbjct: 3082 LDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGA 3141
Query: 1579 QQDLSALQKNQSDLKDLQDDIQ-------------NRATSFATVVKDIEGFMEENQTKLS 1625
+ +Q +S ++ + + + SF +++G M+E +
Sbjct: 3142 PRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMK 3201
Query: 1626 PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKI 1685
+ + ++Q+ L+ E +KE+ T A + A LA K+
Sbjct: 3202 GEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLA----KV 3257
Query: 1686 DALLDWVTSVGSSGGQLLTN-------LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKL 1738
+ + GQ L L ++L + E+ L +++ E+L
Sbjct: 3258 QEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQL 3317
Query: 1739 DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYST 1798
Q E + +E Q Q+ Q Q +D + H ++ E + LQ+ G L+E
Sbjct: 3318 LGQHEELGQEIRECRLQAQDL---RQEGQQLVD-NSHFMSAEVTECLQELEGRLQE---- 3369
Query: 1799 SLAQSEAELKQVQTLQDELQKFLQDHKEFESWL 1831
L ++ A Q LQK Q ++ E+WL
Sbjct: 3370 -LEEAWALRWQRCAESWGLQKLRQRLEQAEAWL 3401
Score = 42.4 bits (98), Expect = 0.013
Identities = 94/453 (20%), Positives = 172/453 (37%), Gaps = 68/453 (15%)
Query: 330 IKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKG----------RIEELYK 379
++Q L+ + P++P L L Q + E+L + +G ++E
Sbjct: 3023 LQQTAALLESRKNPESPKVLAQL--QAVREAHAELLRRAEARGHGLQEQLQLHQLERETL 3080
Query: 380 LLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLE-----LLLQIAN 434
LL+ W+ + D+E G ++E E+ + R V+ L L ++A
Sbjct: 3081 LLDAWLTTKAATAESQDYGQDLE---GVKVLE--EKFDAFRKEVQSLGQAKVYALRKLAG 3135
Query: 435 KIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCES-----DVIMYIQECEGLIRQLQV 489
++ GA + ++ ++A L+ + E+ +V + Q L ++Q
Sbjct: 3136 TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQE 3195
Query: 490 DLQILRDEN----YYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTT 545
+++ E+ + L + RL+ EL + E L + L
Sbjct: 3196 KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA----------CRLGQ 3245
Query: 546 THLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLER 605
H A + + K R + +A +++ L ELL+W +E Q
Sbjct: 3246 LHPAAPGGLAKVQEAWATLQAKAQERGQWLA-QAAQGHAFLGRCQELLAWAQERQELASS 3304
Query: 606 AEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQ-------NFHTSYAET- 657
E D+ E L QH EELG ++E RL + Q N H AE
Sbjct: 3305 EELAEDVAGAEQLL--GQH-----EELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVT 3357
Query: 658 --LGKLETQYCKLKETSSFRMRH------LQSLHKFVSRATAELIWLNEKEEEELAYDWS 709
L +LE + +L+E + R + LQ L + + +A A WL E L D+
Sbjct: 3358 ECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEA---WLACWEGLLLKPDYG 3414
Query: 710 DNNSNISAKRNYFSELTMELEEKQDVFRSLQDT 742
+ S++ + +L L +++ F +Q T
Sbjct: 3415 HSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKT 3447
Score = 37.7 bits (86), Expect = 0.31
Identities = 46/261 (17%), Positives = 103/261 (39%), Gaps = 7/261 (2%)
Query: 591 ELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNF 650
EL ++E ++ + G+ L SV + + + +E + V + ++ Q
Sbjct: 3188 ELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQ-L 3246
Query: 651 HTSYAETLGKLETQYCKLKETSSFRMRHLQSL---HKFVSRATAELIWLNEKEEEELAYD 707
H + L K++ + L+ + R + L H F+ R L W E++E + +
Sbjct: 3247 HPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEE 3306
Query: 708 WSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQ 767
+++ + EL E+ E + + L+ + L +H V ++ +
Sbjct: 3307 LAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGR 3366
Query: 768 LQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDL 827
LQ +++ Q E+ + + E++L + + + D+ S+S +E L
Sbjct: 3367 LQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKP---DYGHSVSDVELL 3423
Query: 828 LQDSMDEKEQLIQSKSSVASL 848
L D ++ L + A +
Sbjct: 3424 LHRHQDLEKLLAAQEEKFAQM 3444
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.353
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 189,048,312
Number of Sequences: 37866
Number of extensions: 8332534
Number of successful extensions: 64704
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 244
Number of HSP's successfully gapped in prelim test: 1321
Number of HSP's that attempted gapping in prelim test: 33048
Number of HSP's gapped (non-prelim): 16050
length of query: 5430
length of database: 18,247,518
effective HSP length: 125
effective length of query: 5305
effective length of database: 13,514,268
effective search space: 71693191740
effective search space used: 71693191740
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 74 (33.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.