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Search of human proteins with 123173752
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|123173752 synaptotagmin XIV-like [Homo sapiens]
(645 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|123173752 synaptotagmin XIV-like [Homo sapiens] 1292 0.0
gi|226342962 synaptotagmin XIV isoform 2 [Homo sapiens] 436 e-122
gi|144226225 synaptotagmin XIV isoform 4 [Homo sapiens] 436 e-122
gi|226342957 synaptotagmin XIV isoform 3 [Homo sapiens] 426 e-119
gi|226342955 synaptotagmin XIV isoform 1 [Homo sapiens] 426 e-119
gi|28376627 synaptotagmin IX [Homo sapiens] 115 1e-25
gi|39752671 synaptotagmin X [Homo sapiens] 115 2e-25
gi|24308219 synaptotagmin IV [Homo sapiens] 114 4e-25
gi|238550198 synaptotagmin III [Homo sapiens] 110 4e-24
gi|238550196 synaptotagmin III [Homo sapiens] 110 4e-24
gi|14150054 synaptotagmin III [Homo sapiens] 110 4e-24
gi|47078261 double C2-like domains, alpha [Homo sapiens] 108 2e-23
gi|45504376 synaptotagmin VI [Homo sapiens] 107 3e-23
gi|209447073 synaptotagmin I [Homo sapiens] 105 1e-22
gi|5032139 synaptotagmin I [Homo sapiens] 105 1e-22
gi|209447070 synaptotagmin I [Homo sapiens] 105 1e-22
gi|29366828 synaptotagmin XII [Homo sapiens] 105 1e-22
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 105 2e-22
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 105 2e-22
gi|211059429 synaptotagmin II [Homo sapiens] 102 8e-22
gi|31543670 synaptotagmin II [Homo sapiens] 102 8e-22
gi|38570146 synaptotagmin VII [Homo sapiens] 100 5e-21
gi|6005997 double C2-like domains, beta [Homo sapiens] 100 7e-21
gi|216548478 synaptotagmin XI [Homo sapiens] 96 1e-19
gi|92859638 synaptotagmin V [Homo sapiens] 93 9e-19
gi|40068038 B/K protein [Homo sapiens] 92 2e-18
gi|239744413 PREDICTED: hypothetical protein LOC390213 [Homo sap... 84 4e-16
gi|31881675 synaptotagmin XV isoform a [Homo sapiens] 72 1e-12
gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens] 66 1e-10
gi|169203543 PREDICTED: similar to hCG21066 [Homo sapiens] 66 1e-10
>gi|123173752 synaptotagmin XIV-like [Homo sapiens]
Length = 645
Score = 1292 bits (3344), Expect = 0.0
Identities = 645/645 (100%), Positives = 645/645 (100%)
Query: 1 MVLAMASQDVQNFFQPFSSWISRVYEALQQAGDMLSASLVNISKQDSKLSDKLDQDLDNI 60
MVLAMASQDVQNFFQPFSSWISRVYEALQQAGDMLSASLVNISKQDSKLSDKLDQDLDNI
Sbjct: 1 MVLAMASQDVQNFFQPFSSWISRVYEALQQAGDMLSASLVNISKQDSKLSDKLDQDLDNI 60
Query: 61 QIQETYFEDEEQDNDWSQEDANSLFLEVDHFSCCNSDLQDSAQNSSPSLSQHAKDSCSTM 120
QIQETYFEDEEQDNDWSQEDANSLFLEVDHFSCCNSDLQDSAQNSSPSLSQHAKDSCSTM
Sbjct: 61 QIQETYFEDEEQDNDWSQEDANSLFLEVDHFSCCNSDLQDSAQNSSPSLSQHAKDSCSTM 120
Query: 121 SQWPNWASDDRKLPHVLSSIAEEEHHLEKQRSGLQHGFDSQLPGTLETVNGKKQVNSFGD 180
SQWPNWASDDRKLPHVLSSIAEEEHHLEKQRSGLQHGFDSQLPGTLETVNGKKQVNSFGD
Sbjct: 121 SQWPNWASDDRKLPHVLSSIAEEEHHLEKQRSGLQHGFDSQLPGTLETVNGKKQVNSFGD 180
Query: 181 DEELSTSSDSDEEVIKQFEISVSRSQSFRSVTSEKGKQTGLEQKPKFSRSLLTHGEDGTE 240
DEELSTSSDSDEEVIKQFEISVSRSQSFRSVTSEKGKQTGLEQKPKFSRSLLTHGEDGTE
Sbjct: 181 DEELSTSSDSDEEVIKQFEISVSRSQSFRSVTSEKGKQTGLEQKPKFSRSLLTHGEDGTE 240
Query: 241 VSACEDLDGASQRRYSENLSYGEDDHIPAHSQSPCERGDAKHHGTSHQESSVVQSLRRQS 300
VSACEDLDGASQRRYSENLSYGEDDHIPAHSQSPCERGDAKHHGTSHQESSVVQSLRRQS
Sbjct: 241 VSACEDLDGASQRRYSENLSYGEDDHIPAHSQSPCERGDAKHHGTSHQESSVVQSLRRQS 300
Query: 301 TEGSLEMETAFNSRGFEDSYATDSSSMWSPEEQDRTNLQVPSGVSEPISKCGDLDVIFEY 360
TEGSLEMETAFNSRGFEDSYATDSSSMWSPEEQDRTNLQVPSGVSEPISKCGDLDVIFEY
Sbjct: 301 TEGSLEMETAFNSRGFEDSYATDSSSMWSPEEQDRTNLQVPSGVSEPISKCGDLDVIFEY 360
Query: 361 RAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRGPNPVFREKVTF 420
RAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRGPNPVFREKVTF
Sbjct: 361 RAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRGPNPVFREKVTF 420
Query: 421 AKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVTLVLEPRSNISSG 480
AKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVTLVLEPRSNISSG
Sbjct: 421 AKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVTLVLEPRSNISSG 480
Query: 481 GSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIKGSHFRNLAVNRA 540
GSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIKGSHFRNLAVNRA
Sbjct: 481 GSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIKGSHFRNLAVNRA 540
Query: 541 PDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRT 600
PDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRT
Sbjct: 541 PDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRT 600
Query: 601 MKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWHTLLES 645
MKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWHTLLES
Sbjct: 601 MKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWHTLLES 645
>gi|226342962 synaptotagmin XIV isoform 2 [Homo sapiens]
Length = 600
Score = 436 bits (1120), Expect = e-122
Identities = 244/485 (50%), Positives = 327/485 (67%), Gaps = 15/485 (3%)
Query: 173 KQVNSFGDDEELSTSSDSDEEVIKQFEISVSRSQSFR-SVTSEKGKQTGLEQKPKFSRSL 231
K NS+ D +E +SS+S++E + ++ ++SR+ + R + + + E + K+S
Sbjct: 119 KIYNSYMDKDEHGSSSESEDEALGKYHEALSRTHNSRLPLADSRQRNYAWETRQKYSP-- 176
Query: 232 LTHGEDGTEVSACEDLDGASQR-RYSENLS------YGEDDHIPAHSQSPCERGDAKHHG 284
L+ DG A D QR R + L Y +D P S +P E GD+K
Sbjct: 177 LSAEYDGYSSEASIDEGNCIQRMRRTPPLDELQPPPYQDDSGSPHLSCTPSEIGDSKCE- 235
Query: 285 TSHQESSVVQSLRRQSTEGSLEMET-AFNSRGFEDSYATDSSSMWSPEEQDR--TNLQVP 341
SH +S S + +EGS E +F+++G+E+ +DS+++ SPE+ ++ Q+P
Sbjct: 236 FSHCSNSPRCSYNKCPSEGSTGHEIESFHNKGYEEDVPSDSTAVLSPEDMSAQGSSSQLP 295
Query: 342 SGVS-EPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKH 400
EP +K G LDV F+Y + QKL VT+ +P +R+G NSWQVH+VLLP KK
Sbjct: 296 KPFDPEPEAKYGTLDVTFDYDSQEQKLLVTVTAVTDIPTYNRTGGNSWQVHLVLLPIKKQ 355
Query: 401 RGRTNIQRGPNPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLH 460
R +T+IQRGP PVF E F +E + AVRFRLY +M +E+++GEK+FYL+ L+
Sbjct: 356 RAKTSIQRGPCPVFTETFKFNHVESEMIGNYAVRFRLYGVHRMKKEKIVGEKIFYLTKLN 415
Query: 461 PEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTG 520
+G+M + ++LEP N S S +S S +S S+STSS QSL HG PE+L+GL YNATTG
Sbjct: 416 LQGKMSLPVILEPSYNHSGCDSQMSVSEMSCSESTSSCQSLEHGSVPEILIGLLYNATTG 475
Query: 521 RLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQ 580
RLS E+IKGSHF+NLA NR P+TY KL LLNS+GQEMS+CKTSIRRGQPNPVYKETFVFQ
Sbjct: 476 RLSAEVIKGSHFKNLAANRPPNTYVKLTLLNSMGQEMSKCKTSIRRGQPNPVYKETFVFQ 535
Query: 581 VALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWH 640
VALFQLSDVTL++SVYN+R+MKRKEMIGWI+LG NSSGEEE +HW EMKE+KGQQ+CRWH
Sbjct: 536 VALFQLSDVTLILSVYNKRSMKRKEMIGWISLGLNSSGEEELNHWTEMKESKGQQVCRWH 595
Query: 641 TLLES 645
LLES
Sbjct: 596 ALLES 600
>gi|144226225 synaptotagmin XIV isoform 4 [Homo sapiens]
Length = 555
Score = 436 bits (1120), Expect = e-122
Identities = 244/485 (50%), Positives = 327/485 (67%), Gaps = 15/485 (3%)
Query: 173 KQVNSFGDDEELSTSSDSDEEVIKQFEISVSRSQSFR-SVTSEKGKQTGLEQKPKFSRSL 231
K NS+ D +E +SS+S++E + ++ ++SR+ + R + + + E + K+S
Sbjct: 74 KIYNSYMDKDEHGSSSESEDEALGKYHEALSRTHNSRLPLADSRQRNYAWETRQKYSP-- 131
Query: 232 LTHGEDGTEVSACEDLDGASQR-RYSENLS------YGEDDHIPAHSQSPCERGDAKHHG 284
L+ DG A D QR R + L Y +D P S +P E GD+K
Sbjct: 132 LSAEYDGYSSEASIDEGNCIQRMRRTPPLDELQPPPYQDDSGSPHLSCTPSEIGDSKCE- 190
Query: 285 TSHQESSVVQSLRRQSTEGSLEMET-AFNSRGFEDSYATDSSSMWSPEEQDR--TNLQVP 341
SH +S S + +EGS E +F+++G+E+ +DS+++ SPE+ ++ Q+P
Sbjct: 191 FSHCSNSPRCSYNKCPSEGSTGHEIESFHNKGYEEDVPSDSTAVLSPEDMSAQGSSSQLP 250
Query: 342 SGVS-EPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKH 400
EP +K G LDV F+Y + QKL VT+ +P +R+G NSWQVH+VLLP KK
Sbjct: 251 KPFDPEPEAKYGTLDVTFDYDSQEQKLLVTVTAVTDIPTYNRTGGNSWQVHLVLLPIKKQ 310
Query: 401 RGRTNIQRGPNPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLH 460
R +T+IQRGP PVF E F +E + AVRFRLY +M +E+++GEK+FYL+ L+
Sbjct: 311 RAKTSIQRGPCPVFTETFKFNHVESEMIGNYAVRFRLYGVHRMKKEKIVGEKIFYLTKLN 370
Query: 461 PEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTG 520
+G+M + ++LEP N S S +S S +S S+STSS QSL HG PE+L+GL YNATTG
Sbjct: 371 LQGKMSLPVILEPSYNHSGCDSQMSVSEMSCSESTSSCQSLEHGSVPEILIGLLYNATTG 430
Query: 521 RLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQ 580
RLS E+IKGSHF+NLA NR P+TY KL LLNS+GQEMS+CKTSIRRGQPNPVYKETFVFQ
Sbjct: 431 RLSAEVIKGSHFKNLAANRPPNTYVKLTLLNSMGQEMSKCKTSIRRGQPNPVYKETFVFQ 490
Query: 581 VALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWH 640
VALFQLSDVTL++SVYN+R+MKRKEMIGWI+LG NSSGEEE +HW EMKE+KGQQ+CRWH
Sbjct: 491 VALFQLSDVTLILSVYNKRSMKRKEMIGWISLGLNSSGEEELNHWTEMKESKGQQVCRWH 550
Query: 641 TLLES 645
LLES
Sbjct: 551 ALLES 555
>gi|226342957 synaptotagmin XIV isoform 3 [Homo sapiens]
Length = 574
Score = 426 bits (1095), Expect = e-119
Identities = 245/504 (48%), Positives = 327/504 (64%), Gaps = 34/504 (6%)
Query: 173 KQVNSFGDDEELSTSSDSDEEVIKQFEISVSRSQSFR-SVTSEKGKQTGLEQKPKFSRSL 231
K NS+ D +E +SS+S++E + ++ ++SR+ + R + + + E + K+S
Sbjct: 74 KIYNSYMDKDEHGSSSESEDEALGKYHEALSRTHNSRLPLADSRQRNYAWETRQKYSP-- 131
Query: 232 LTHGEDGTEVSACEDLDGASQR-RYSENLS------YGEDDHIPAHSQSPCERGDAKHHG 284
L+ DG A D QR R + L Y +D P S +P E GD+K
Sbjct: 132 LSAEYDGYSSEASIDEGNCIQRMRRTPPLDELQPPPYQDDSGSPHLSCTPSEIGDSKCE- 190
Query: 285 TSHQESSVVQSLRRQSTEGSLEMET-AFNSRGFEDSYATDSSSMWSPEEQDR--TNLQVP 341
SH +S S + +EGS E +F+++G+E+ +DS+++ SPE+ ++ Q+P
Sbjct: 191 FSHCSNSPRCSYNKCPSEGSTGHEIESFHNKGYEEDVPSDSTAVLSPEDMSAQGSSSQLP 250
Query: 342 SGVS-EPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKH 400
EP +K G LDV F+Y + QKL VT+ +P +R+G NSWQVH+VLLP KK
Sbjct: 251 KPFDPEPEAKYGTLDVTFDYDSQEQKLLVTVTAVTDIPTYNRTGGNSWQVHLVLLPIKKQ 310
Query: 401 RGRTNIQRGPNPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLH 460
R +T+IQRGP PVF E F +E + AVRFRLY +M +E+++GEK+FYL+ L+
Sbjct: 311 RAKTSIQRGPCPVFTETFKFNHVESEMIGNYAVRFRLYGVHRMKKEKIVGEKIFYLTKLN 370
Query: 461 PEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTG 520
+G+M + ++LEP N S S +S S +S S+STSS QSL HG PE+L+GL YNATTG
Sbjct: 371 LQGKMSLPVILEPSYNHSGCDSQMSVSEMSCSESTSSCQSLEHGSVPEILIGLLYNATTG 430
Query: 521 RLSVEMIKGSHFRNLAVNRAP-------------------DTYGKLFLLNSVGQEMSRCK 561
RLS E+IKGSHF+NLA NR P DTY KL LLNS+GQEMS+CK
Sbjct: 431 RLSAEVIKGSHFKNLAANRPPNGLFCCLKHLIGGQVYIIRDTYVKLTLLNSMGQEMSKCK 490
Query: 562 TSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEE 621
TSIRRGQPNPVYKETFVFQVALFQLSDVTL++SVYN+R+MKRKEMIGWI+LG NSSGEEE
Sbjct: 491 TSIRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNKRSMKRKEMIGWISLGLNSSGEEE 550
Query: 622 QDHWEEMKETKGQQICRWHTLLES 645
+HW EMKE+KGQQ+CRWH LLES
Sbjct: 551 LNHWTEMKESKGQQVCRWHALLES 574
>gi|226342955 synaptotagmin XIV isoform 1 [Homo sapiens]
Length = 619
Score = 426 bits (1095), Expect = e-119
Identities = 245/504 (48%), Positives = 327/504 (64%), Gaps = 34/504 (6%)
Query: 173 KQVNSFGDDEELSTSSDSDEEVIKQFEISVSRSQSFR-SVTSEKGKQTGLEQKPKFSRSL 231
K NS+ D +E +SS+S++E + ++ ++SR+ + R + + + E + K+S
Sbjct: 119 KIYNSYMDKDEHGSSSESEDEALGKYHEALSRTHNSRLPLADSRQRNYAWETRQKYSP-- 176
Query: 232 LTHGEDGTEVSACEDLDGASQR-RYSENLS------YGEDDHIPAHSQSPCERGDAKHHG 284
L+ DG A D QR R + L Y +D P S +P E GD+K
Sbjct: 177 LSAEYDGYSSEASIDEGNCIQRMRRTPPLDELQPPPYQDDSGSPHLSCTPSEIGDSKCE- 235
Query: 285 TSHQESSVVQSLRRQSTEGSLEMET-AFNSRGFEDSYATDSSSMWSPEEQDR--TNLQVP 341
SH +S S + +EGS E +F+++G+E+ +DS+++ SPE+ ++ Q+P
Sbjct: 236 FSHCSNSPRCSYNKCPSEGSTGHEIESFHNKGYEEDVPSDSTAVLSPEDMSAQGSSSQLP 295
Query: 342 SGVS-EPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKH 400
EP +K G LDV F+Y + QKL VT+ +P +R+G NSWQVH+VLLP KK
Sbjct: 296 KPFDPEPEAKYGTLDVTFDYDSQEQKLLVTVTAVTDIPTYNRTGGNSWQVHLVLLPIKKQ 355
Query: 401 RGRTNIQRGPNPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLH 460
R +T+IQRGP PVF E F +E + AVRFRLY +M +E+++GEK+FYL+ L+
Sbjct: 356 RAKTSIQRGPCPVFTETFKFNHVESEMIGNYAVRFRLYGVHRMKKEKIVGEKIFYLTKLN 415
Query: 461 PEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTG 520
+G+M + ++LEP N S S +S S +S S+STSS QSL HG PE+L+GL YNATTG
Sbjct: 416 LQGKMSLPVILEPSYNHSGCDSQMSVSEMSCSESTSSCQSLEHGSVPEILIGLLYNATTG 475
Query: 521 RLSVEMIKGSHFRNLAVNRAP-------------------DTYGKLFLLNSVGQEMSRCK 561
RLS E+IKGSHF+NLA NR P DTY KL LLNS+GQEMS+CK
Sbjct: 476 RLSAEVIKGSHFKNLAANRPPNGLFCCLKHLIGGQVYIIRDTYVKLTLLNSMGQEMSKCK 535
Query: 562 TSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEE 621
TSIRRGQPNPVYKETFVFQVALFQLSDVTL++SVYN+R+MKRKEMIGWI+LG NSSGEEE
Sbjct: 536 TSIRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNKRSMKRKEMIGWISLGLNSSGEEE 595
Query: 622 QDHWEEMKETKGQQICRWHTLLES 645
+HW EMKE+KGQQ+CRWH LLES
Sbjct: 596 LNHWTEMKESKGQQVCRWHALLES 619
>gi|28376627 synaptotagmin IX [Homo sapiens]
Length = 491
Score = 115 bits (288), Expect = 1e-25
Identities = 105/391 (26%), Positives = 166/391 (42%), Gaps = 29/391 (7%)
Query: 256 SENLSYGEDDHIPAHSQSPCERGDAKHHGTSHQESSVVQSLRRQSTEGSLEMETA-FNSR 314
S +S+ D IP +Q+ + A Q + S R S L + FN +
Sbjct: 126 SMKISHTSPD-IPLSTQTGIQENCAHGVRVQRQVTEPTSSARHNSIRRQLNLSNPDFNIQ 184
Query: 315 GFEDSYATDSSSMWSPEEQDRTNLQVPSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRA 374
+ PE + +L G CG L+ I +Y ++L V I +A
Sbjct: 185 QLQKQEQLTGIGRIKPELYKQRSLDNDDGRRSNSKACGKLNFILKYDCDLEQLIVKIHKA 244
Query: 375 QGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRGP-NPVFREKVTFAKLEPRDVAACAV 433
LP KD SG + V + LLP +K + +T + R NPVF E F + D+ A +
Sbjct: 245 VNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLFP-VPYNDLEARKL 303
Query: 434 RFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSD 493
F +Y + +R ++G+ + + H + L PR + D
Sbjct: 304 HFSVYDFDRFSRHDLIGQVV--VDHF-------LDLADFPRE------------CILWKD 342
Query: 494 STSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSV 553
T G EL+ L Y T GRL++ +IK + + + + A D Y K+ L+
Sbjct: 343 IEYVTNDNVDLG--ELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCD- 399
Query: 554 GQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALG 613
G+ + + KTS +R NPVY E VF V + + L I+V + + E+IG +G
Sbjct: 400 GRRLKKRKTSTKRNTLNPVYNEAIVFDVPPENIDQIHLSIAVMDYDRVGHNEIIGVCQVG 459
Query: 614 QNSSGEEEQDHWEEMKETKGQQICRWHTLLE 644
N + +DHW EM + I WH+L+E
Sbjct: 460 -NEAERLGRDHWSEMLSYPRKPIAHWHSLVE 489
>gi|39752671 synaptotagmin X [Homo sapiens]
Length = 523
Score = 115 bits (287), Expect = 2e-25
Identities = 99/388 (25%), Positives = 171/388 (44%), Gaps = 37/388 (9%)
Query: 267 IPAHSQSPCERGDAKHHGTSHQESSVVQSLRRQSTEGSLEMETAFNSRGF--------ED 318
IPA Q+ + KH Q + S R S L + +S F +
Sbjct: 140 IPAEVQTALKEHLIKHARVQRQITEPTSSTRHSSFRRHLPRQMQVSSVDFSMGTEPVLQR 199
Query: 319 SYATDSSSMWSPEEQDRTNLQVPSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLP 378
T S PE + ++ +E + CG L+ +Y ++ L V I++A LP
Sbjct: 200 GETTTSIGRIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQYDYENELLVVKIIKALDLP 259
Query: 379 DKDRSGVNSWQVHVVLLPGKKHRGRTNIQRGP-NPVFREKVTFAKLEPRDVAACAVRFRL 437
KD +G + V + LLP +K + +T + R NP+F E F + ++ + F +
Sbjct: 260 AKDFTGTSDPYVKMYLLPDRKKKFQTRVHRKTLNPLFDETFQF-PVAYDQLSNRKLHFSV 318
Query: 438 YAARKMTRERMMGEKLFYLSHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSD-STS 496
Y + +R M+GE ++L+ +S LS A D +
Sbjct: 319 YDFDRFSRHDMIGE-----------------VILDNLFEVSD----LSREATVWKDIHCA 357
Query: 497 STQSLSHGGAPELLVGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQE 556
+T+S+ G E++ L Y T GR+++ +IK + + + + + D Y K+ L+ G+
Sbjct: 358 TTESIDLG---EIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLM-CEGRR 413
Query: 557 MSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNS 616
+ + KT+ ++ NPVY E +F + + V+L I+V + + E+IG G ++
Sbjct: 414 LKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDA 473
Query: 617 SGEEEQDHWEEMKETKGQQICRWHTLLE 644
G +DHW EM + I WH LLE
Sbjct: 474 EG-LGRDHWNEMLAYHRKPITHWHPLLE 500
>gi|24308219 synaptotagmin IV [Homo sapiens]
Length = 425
Score = 114 bits (284), Expect = 4e-25
Identities = 83/301 (27%), Positives = 140/301 (46%), Gaps = 27/301 (8%)
Query: 346 EPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQ-VHVVLLPGKKHRGRT 404
E K G L EY + V I A+GLP D + S + + +LP KKH+ +T
Sbjct: 149 EKQEKLGTLFFSLEYNFERKAFVVNIKEARGLPAMDEQSMTSDPYIKMTILPEKKHKVKT 208
Query: 405 NIQRGP-NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLHPEG 463
+ R +P F E TF + + A+ F + + + +R+ ++GE L LS +
Sbjct: 209 RVLRKTLDPAFDETFTFYGIPYTQIQELALHFTILSFDRFSRDDIIGEVLIPLSGIE--- 265
Query: 464 EMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTGRLS 523
+S G ++ + + SS G ELL+ L Y +TT L+
Sbjct: 266 -------------LSEGKMLMNREIIKRNVRKSS-------GRGELLISLCYQSTTNTLT 305
Query: 524 VEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVAL 583
V ++K H V+ D Y K+ L ++ + +S+ KT +++ PN V+ E FVF +
Sbjct: 306 VVVLKARHLPKSDVSGLSDPYVKVNLYHAK-KRISKKKTHVKKCTPNAVFNELFVFDIPC 364
Query: 584 FQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWHTLL 643
L D+++ V + R E+IG + LG + G +HW+E+ + +QI +WH L
Sbjct: 365 EGLEDISVEFLVLDSERGSRNEVIGQLVLGAAAEG-TGGEHWKEICDYPRRQIAKWHVLC 423
Query: 644 E 644
+
Sbjct: 424 D 424
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 110 bits (275), Expect = 4e-24
Identities = 86/308 (27%), Positives = 142/308 (46%), Gaps = 34/308 (11%)
Query: 342 SGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHR 401
SG + + CG + Y S +L V I++A LP KD +G + V + LLP +K +
Sbjct: 291 SGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKK 350
Query: 402 GRTNIQRGP-NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGE----KLFYL 456
+T + R NPVF E F+ + ++A + F +Y + +R ++G+ L L
Sbjct: 351 FQTKVHRKTLNPVFNETFQFS-VPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLEL 409
Query: 457 SHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYN 516
+ P+ + +V GGS + EL L Y
Sbjct: 410 AEQPPDRPLWRDIV--------EGGSEKADLG-------------------ELNFSLCYL 442
Query: 517 ATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKET 576
T GRL+V +IK S+ + + + D Y K L+ S G+ + + KTSI++ NP Y E
Sbjct: 443 PTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLI-SEGRRLKKRKTSIKKNTLNPTYNEA 501
Query: 577 FVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQI 636
VF VA + +V L I+V + + E+IG +G +++ ++HW EM + +
Sbjct: 502 LVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHWAEMLANPRKPV 561
Query: 637 CRWHTLLE 644
WH L+E
Sbjct: 562 EHWHQLVE 569
Score = 47.0 bits (110), Expect = 5e-05
Identities = 38/152 (25%), Positives = 63/152 (41%), Gaps = 6/152 (3%)
Query: 461 PEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTG 520
P GE K L+ + + + G P S ++ + + L Y +
Sbjct: 258 PGGEEKAKLIGQIKPELYQG---TGPGGRRSGGGPGSGEAGTGAPCGRISFALRYLYGSD 314
Query: 521 RLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQ 580
+L V +++ N D Y K++LL + +T + R NPV+ ETF F
Sbjct: 315 QLVVRILQALDLPAKDSNGFSDPYVKIYLLPD---RKKKFQTKVHRKTLNPVFNETFQFS 371
Query: 581 VALFQLSDVTLMISVYNRRTMKRKEMIGWIAL 612
V L +L+ L SVY+ R ++IG + L
Sbjct: 372 VPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 110 bits (275), Expect = 4e-24
Identities = 86/308 (27%), Positives = 142/308 (46%), Gaps = 34/308 (11%)
Query: 342 SGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHR 401
SG + + CG + Y S +L V I++A LP KD +G + V + LLP +K +
Sbjct: 291 SGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKK 350
Query: 402 GRTNIQRGP-NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGE----KLFYL 456
+T + R NPVF E F+ + ++A + F +Y + +R ++G+ L L
Sbjct: 351 FQTKVHRKTLNPVFNETFQFS-VPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLEL 409
Query: 457 SHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYN 516
+ P+ + +V GGS + EL L Y
Sbjct: 410 AEQPPDRPLWRDIV--------EGGSEKADLG-------------------ELNFSLCYL 442
Query: 517 ATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKET 576
T GRL+V +IK S+ + + + D Y K L+ S G+ + + KTSI++ NP Y E
Sbjct: 443 PTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLI-SEGRRLKKRKTSIKKNTLNPTYNEA 501
Query: 577 FVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQI 636
VF VA + +V L I+V + + E+IG +G +++ ++HW EM + +
Sbjct: 502 LVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHWAEMLANPRKPV 561
Query: 637 CRWHTLLE 644
WH L+E
Sbjct: 562 EHWHQLVE 569
Score = 47.0 bits (110), Expect = 5e-05
Identities = 38/152 (25%), Positives = 63/152 (41%), Gaps = 6/152 (3%)
Query: 461 PEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTG 520
P GE K L+ + + + G P S ++ + + L Y +
Sbjct: 258 PGGEEKAKLIGQIKPELYQG---TGPGGRRSGGGPGSGEAGTGAPCGRISFALRYLYGSD 314
Query: 521 RLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQ 580
+L V +++ N D Y K++LL + +T + R NPV+ ETF F
Sbjct: 315 QLVVRILQALDLPAKDSNGFSDPYVKIYLLPD---RKKKFQTKVHRKTLNPVFNETFQFS 371
Query: 581 VALFQLSDVTLMISVYNRRTMKRKEMIGWIAL 612
V L +L+ L SVY+ R ++IG + L
Sbjct: 372 VPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 110 bits (275), Expect = 4e-24
Identities = 86/308 (27%), Positives = 142/308 (46%), Gaps = 34/308 (11%)
Query: 342 SGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHR 401
SG + + CG + Y S +L V I++A LP KD +G + V + LLP +K +
Sbjct: 291 SGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKK 350
Query: 402 GRTNIQRGP-NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGE----KLFYL 456
+T + R NPVF E F+ + ++A + F +Y + +R ++G+ L L
Sbjct: 351 FQTKVHRKTLNPVFNETFQFS-VPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLEL 409
Query: 457 SHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYN 516
+ P+ + +V GGS + EL L Y
Sbjct: 410 AEQPPDRPLWRDIV--------EGGSEKADLG-------------------ELNFSLCYL 442
Query: 517 ATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKET 576
T GRL+V +IK S+ + + + D Y K L+ S G+ + + KTSI++ NP Y E
Sbjct: 443 PTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLI-SEGRRLKKRKTSIKKNTLNPTYNEA 501
Query: 577 FVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQI 636
VF VA + +V L I+V + + E+IG +G +++ ++HW EM + +
Sbjct: 502 LVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHWAEMLANPRKPV 561
Query: 637 CRWHTLLE 644
WH L+E
Sbjct: 562 EHWHQLVE 569
Score = 47.0 bits (110), Expect = 5e-05
Identities = 38/152 (25%), Positives = 63/152 (41%), Gaps = 6/152 (3%)
Query: 461 PEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTG 520
P GE K L+ + + + G P S ++ + + L Y +
Sbjct: 258 PGGEEKAKLIGQIKPELYQG---TGPGGRRSGGGPGSGEAGTGAPCGRISFALRYLYGSD 314
Query: 521 RLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQ 580
+L V +++ N D Y K++LL + +T + R NPV+ ETF F
Sbjct: 315 QLVVRILQALDLPAKDSNGFSDPYVKIYLLPD---RKKKFQTKVHRKTLNPVFNETFQFS 371
Query: 581 VALFQLSDVTLMISVYNRRTMKRKEMIGWIAL 612
V L +L+ L SVY+ R ++IG + L
Sbjct: 372 VPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 108 bits (269), Expect = 2e-23
Identities = 85/312 (27%), Positives = 150/312 (48%), Gaps = 11/312 (3%)
Query: 339 QVPSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPG- 397
+V S S+ + G L+ Y AS L +I+RA+GL D +G+ V + LLPG
Sbjct: 78 EVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGA 137
Query: 398 -KKHRGRTNIQRGP-NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFY 455
K ++ +T QR NPV+ E +T++ + D+ +R + K++ +GE
Sbjct: 138 CKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVP 197
Query: 456 LSHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGA-----PELL 510
L L P + + LE + ++S S +S + S + G +L
Sbjct: 198 LRRLKPSQKKHFNICLERQVPLASPSS-MSAALRGISCYLKELEQAEQGQGLLEERGRIL 256
Query: 511 VGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPN 570
+ LSY++ L V +++ +H + VN D Y K +L V ++ S+ KT +++ N
Sbjct: 257 LSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKK-SKHKTCVKKKTLN 315
Query: 571 PVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKE 630
P + E F +++ L L+ TL ++V++ K + IG ++LG + GE + HW + +
Sbjct: 316 PEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARK-HWSDCLQ 374
Query: 631 TKGQQICRWHTL 642
+ RWHTL
Sbjct: 375 QPDAALERWHTL 386
>gi|45504376 synaptotagmin VI [Homo sapiens]
Length = 425
Score = 107 bits (268), Expect = 3e-23
Identities = 92/384 (23%), Positives = 165/384 (42%), Gaps = 32/384 (8%)
Query: 267 IPAHSQSPCERGDAKHHGTSHQESSVVQSLRRQSTEGSLEMETAFNSRGFEDSYATDSSS 326
IPA Q + +H Q + S R S + L + +S + + +
Sbjct: 56 IPAEVQMSVKEHIMRHTRLQRQTTEPASSTRHTSFKRHLPRQMHVSSVDYGNELPPAAEQ 115
Query: 327 MWS-----PEEQDRTNLQVPSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKD 381
S PE + ++ SE CG ++ Y ++ L V I++A LP KD
Sbjct: 116 PTSIGRIKPELYKQKSVDGEDAKSEATKSCGKINFSLRYDYETETLIVRILKAFDLPAKD 175
Query: 382 RSGVNSWQVHVVLLPGKKHRGRTNIQRGP-NPVFREKVTFAKLEPRDVAACAVRFRLYAA 440
G + V + LLP +K + +T + R NP F E F + ++A + ++
Sbjct: 176 FCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFHFP-VPYEELADRKLHLSVFDF 234
Query: 441 RKMTRERMMGEKLFYLSHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQS 500
+ +R M+GE + N+ +++ ++++S
Sbjct: 235 DRFSRHDMIGEVIL--------------------DNLFEASDLSRETSIWKDIQYATSES 274
Query: 501 LSHGGAPELLVGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRC 560
+ G E++ L Y T GRL++ +IK + + + + D Y K+ LL G+ + +
Sbjct: 275 VDLG---EIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCD-GRRLKKK 330
Query: 561 KTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEE 620
KT+I++ NPVY E +F + + V+L+ISV + + E+IG +G + G
Sbjct: 331 KTTIKKNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGITAEG-L 389
Query: 621 EQDHWEEMKETKGQQICRWHTLLE 644
+DHW EM + I WH+L+E
Sbjct: 390 GRDHWNEMLAYPRKPIAHWHSLVE 413
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 105 bits (263), Expect = 1e-22
Identities = 75/294 (25%), Positives = 137/294 (46%), Gaps = 28/294 (9%)
Query: 350 KCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRG 409
K G L +Y + +L V I++A LP D G + V V LLP KK + T + R
Sbjct: 142 KLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRK 201
Query: 410 P-NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVT 468
NPVF E+ TF K+ ++ + +Y + ++ ++GE KV
Sbjct: 202 TLNPVFNEQFTF-KVPYSELGGKTLVMAVYDFDRFSKHDIIGE-------------FKVP 247
Query: 469 LVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIK 528
+ +++ L + + ++ L Y T G+L+V +++
Sbjct: 248 MNTVDFGHVTEEWRDLQSAEKEEQEKLG-----------DICFSLRYVPTAGKLTVVILE 296
Query: 529 GSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSD 588
+ + + V D Y K+ L+ + G+ + + KT+I++ NP Y E+F F+V Q+
Sbjct: 297 AKNLKKMDVGGLSDPYVKIHLMQN-GKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQK 355
Query: 589 VTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWHTL 642
V ++++V + + + + IG + +G NS+G E + HW +M + I +WHTL
Sbjct: 356 VQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELR-HWSDMLANPRRPIAQWHTL 408
Score = 34.3 bits (77), Expect = 0.37
Identities = 24/82 (29%), Positives = 38/82 (46%), Gaps = 3/82 (3%)
Query: 342 SGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKH- 400
S E K GD+ Y + KLTV I+ A+ L D G++ V + L+ K
Sbjct: 265 SAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRL 324
Query: 401 -RGRTNIQRGP-NPVFREKVTF 420
+ +T I++ NP + E +F
Sbjct: 325 KKKKTTIKKNTLNPYYNESFSF 346
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 105 bits (263), Expect = 1e-22
Identities = 75/294 (25%), Positives = 137/294 (46%), Gaps = 28/294 (9%)
Query: 350 KCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRG 409
K G L +Y + +L V I++A LP D G + V V LLP KK + T + R
Sbjct: 142 KLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRK 201
Query: 410 P-NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVT 468
NPVF E+ TF K+ ++ + +Y + ++ ++GE KV
Sbjct: 202 TLNPVFNEQFTF-KVPYSELGGKTLVMAVYDFDRFSKHDIIGE-------------FKVP 247
Query: 469 LVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIK 528
+ +++ L + + ++ L Y T G+L+V +++
Sbjct: 248 MNTVDFGHVTEEWRDLQSAEKEEQEKLG-----------DICFSLRYVPTAGKLTVVILE 296
Query: 529 GSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSD 588
+ + + V D Y K+ L+ + G+ + + KT+I++ NP Y E+F F+V Q+
Sbjct: 297 AKNLKKMDVGGLSDPYVKIHLMQN-GKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQK 355
Query: 589 VTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWHTL 642
V ++++V + + + + IG + +G NS+G E + HW +M + I +WHTL
Sbjct: 356 VQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELR-HWSDMLANPRRPIAQWHTL 408
Score = 34.3 bits (77), Expect = 0.37
Identities = 24/82 (29%), Positives = 38/82 (46%), Gaps = 3/82 (3%)
Query: 342 SGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKH- 400
S E K GD+ Y + KLTV I+ A+ L D G++ V + L+ K
Sbjct: 265 SAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRL 324
Query: 401 -RGRTNIQRGP-NPVFREKVTF 420
+ +T I++ NP + E +F
Sbjct: 325 KKKKTTIKKNTLNPYYNESFSF 346
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 105 bits (263), Expect = 1e-22
Identities = 75/294 (25%), Positives = 137/294 (46%), Gaps = 28/294 (9%)
Query: 350 KCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRG 409
K G L +Y + +L V I++A LP D G + V V LLP KK + T + R
Sbjct: 142 KLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRK 201
Query: 410 P-NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVT 468
NPVF E+ TF K+ ++ + +Y + ++ ++GE KV
Sbjct: 202 TLNPVFNEQFTF-KVPYSELGGKTLVMAVYDFDRFSKHDIIGE-------------FKVP 247
Query: 469 LVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIK 528
+ +++ L + + ++ L Y T G+L+V +++
Sbjct: 248 MNTVDFGHVTEEWRDLQSAEKEEQEKLG-----------DICFSLRYVPTAGKLTVVILE 296
Query: 529 GSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSD 588
+ + + V D Y K+ L+ + G+ + + KT+I++ NP Y E+F F+V Q+
Sbjct: 297 AKNLKKMDVGGLSDPYVKIHLMQN-GKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQK 355
Query: 589 VTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWHTL 642
V ++++V + + + + IG + +G NS+G E + HW +M + I +WHTL
Sbjct: 356 VQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELR-HWSDMLANPRRPIAQWHTL 408
Score = 34.3 bits (77), Expect = 0.37
Identities = 24/82 (29%), Positives = 38/82 (46%), Gaps = 3/82 (3%)
Query: 342 SGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKH- 400
S E K GD+ Y + KLTV I+ A+ L D G++ V + L+ K
Sbjct: 265 SAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRL 324
Query: 401 -RGRTNIQRGP-NPVFREKVTF 420
+ +T I++ NP + E +F
Sbjct: 325 KKKKTTIKKNTLNPYYNESFSF 346
>gi|29366828 synaptotagmin XII [Homo sapiens]
Length = 421
Score = 105 bits (263), Expect = 1e-22
Identities = 96/392 (24%), Positives = 170/392 (43%), Gaps = 37/392 (9%)
Query: 252 QRRYSENLSYGEDDHIPA-HSQSPCERGDAKHHGTSHQESSVVQSLRRQSTEGSLEMETA 310
Q++Y E+ + + +PA ++Q RG G+ S+ + S G LE+
Sbjct: 63 QQKYGESCAEAREKRVPAWNAQRASTRGPPSRKGSL----SIEDTFESISELGPLEL--- 115
Query: 311 FNSRGFEDSYATDSSSMWSPEEQDRTNLQVPSGVSEPISKCGDLDVIFEYRAASQKLTVT 370
G E A + S ++ S G ++V EY AS L V
Sbjct: 116 ---MGRELDLAPYGTLRKSQSADSLNSISSVSNTFGQDFTLGQVEVSMEYDTASHTLNVA 172
Query: 371 IVRAQGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRGPNPVFREKVTFAKLEPRDVAA 430
+++ + L +++ + S + V LLP ++ G + IQR +F ++ L+P +
Sbjct: 173 VMQGKDLLEREEASFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSIPLDPTALEE 232
Query: 431 CAVRFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVS 490
++RF ++ + R G LS L L L+P SG L
Sbjct: 233 KSLRFSVFGIDEDERNVSTGVVELKLSVLD--------LPLQP----FSGWLYLQD---- 276
Query: 491 HSDSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLL 550
Q+ + E+L+ LSY T RL+V ++K + D + K++LL
Sbjct: 277 --------QNKAADAVGEILLSLSYLPTAERLTVVVVKAKNLIWTNDKTTADPFVKVYLL 328
Query: 551 NSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWI 610
G++MS+ KT+++R PNPV+ E +F V L D++L ++V + R + +G +
Sbjct: 329 QD-GRKMSKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHV 387
Query: 611 ALGQNSSGEEEQDHWEEMKETKGQQICRWHTL 642
+G ++SG HW +M T + + WH +
Sbjct: 388 IIGPSASG-MGTTHWNQMLATLRRPVSMWHAV 418
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 105 bits (261), Expect = 2e-22
Identities = 87/319 (27%), Positives = 145/319 (45%), Gaps = 14/319 (4%)
Query: 330 PEEQDRTNLQVPSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQ 389
PEE++ + S S+ + G L+ Y + L TI++A+GL D +G+
Sbjct: 375 PEEEEE---EANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPY 431
Query: 390 VHVVLLPG--KKHRGRTNIQRGP-NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRE 446
V + LLPG K ++ RT R NP++ E + + + D+ +R + K
Sbjct: 432 VKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHN 491
Query: 447 RMMGEKLFYLSHLHPEGEMKVTLVLE---PRSNISSGGSPLSPSAVSHSDSTSSTQSLSH 503
+GE F L L P + LE P + GS A+ + +
Sbjct: 492 EFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARG-MALYEEEQVERVGDIEE 550
Query: 504 GGAPELLVGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTS 563
G ++LV L Y+ G L V +I+ H + N D + KL+L +G++ ++ KT
Sbjct: 551 RG--KILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKK-AKHKTQ 607
Query: 564 IRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQD 623
I++ NP + E F + + L+ +L ISV++ K + IG LG ++ GE +
Sbjct: 608 IKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLK- 666
Query: 624 HWEEMKETKGQQICRWHTL 642
HW E + K ++I RWH L
Sbjct: 667 HWYECLKNKDKKIERWHQL 685
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 105 bits (261), Expect = 2e-22
Identities = 87/319 (27%), Positives = 145/319 (45%), Gaps = 14/319 (4%)
Query: 330 PEEQDRTNLQVPSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQ 389
PEE++ + S S+ + G L+ Y + L TI++A+GL D +G+
Sbjct: 371 PEEEEE---EANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPY 427
Query: 390 VHVVLLPG--KKHRGRTNIQRGP-NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRE 446
V + LLPG K ++ RT R NP++ E + + + D+ +R + K
Sbjct: 428 VKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHN 487
Query: 447 RMMGEKLFYLSHLHPEGEMKVTLVLE---PRSNISSGGSPLSPSAVSHSDSTSSTQSLSH 503
+GE F L L P + LE P + GS A+ + +
Sbjct: 488 EFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARG-MALYEEEQVERVGDIEE 546
Query: 504 GGAPELLVGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTS 563
G ++LV L Y+ G L V +I+ H + N D + KL+L +G++ ++ KT
Sbjct: 547 RG--KILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKK-AKHKTQ 603
Query: 564 IRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQD 623
I++ NP + E F + + L+ +L ISV++ K + IG LG ++ GE +
Sbjct: 604 IKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLK- 662
Query: 624 HWEEMKETKGQQICRWHTL 642
HW E + K ++I RWH L
Sbjct: 663 HWYECLKNKDKKIERWHQL 681
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 102 bits (255), Expect = 8e-22
Identities = 73/292 (25%), Positives = 137/292 (46%), Gaps = 28/292 (9%)
Query: 352 GDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRGP- 410
G L +Y + +LTV +++A LP D G + V V LLP KK + T + R
Sbjct: 141 GKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTL 200
Query: 411 NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVTLV 470
NP F E TF K+ +++ + +Y + ++ ++GE +KV +
Sbjct: 201 NPAFNETFTF-KVPYQELGGKTLVMAIYDFDRFSKHDIIGE-------------VKVPM- 245
Query: 471 LEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIKGS 530
N G P+ + L ++ L Y T G+L+V +++
Sbjct: 246 -----NTVDLGQPIEEWRDLQGGEKEEPEKLG-----DICTSLRYVPTAGKLTVCILEAK 295
Query: 531 HFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVT 590
+ + + V D Y K+ L+ + G+ + + KT++++ NP + E+F F++ Q+ V
Sbjct: 296 NLKKMDVGGLSDPYVKIHLMQN-GKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQ 354
Query: 591 LMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWHTL 642
++++V + + + E IG I +G N++G E + HW +M + I +WH+L
Sbjct: 355 VVVTVLDYDKLGKNEAIGKIFVGSNATGTELR-HWSDMLANPRRPIAQWHSL 405
Score = 35.0 bits (79), Expect = 0.21
Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 3/81 (3%)
Query: 343 GVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKH-- 400
G E K GD+ Y + KLTV I+ A+ L D G++ V + L+ K
Sbjct: 263 GEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLK 322
Query: 401 RGRTNIQRGP-NPVFREKVTF 420
+ +T +++ NP F E +F
Sbjct: 323 KKKTTVKKKTLNPYFNESFSF 343
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 102 bits (255), Expect = 8e-22
Identities = 73/292 (25%), Positives = 137/292 (46%), Gaps = 28/292 (9%)
Query: 352 GDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRGP- 410
G L +Y + +LTV +++A LP D G + V V LLP KK + T + R
Sbjct: 141 GKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTL 200
Query: 411 NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVTLV 470
NP F E TF K+ +++ + +Y + ++ ++GE +KV +
Sbjct: 201 NPAFNETFTF-KVPYQELGGKTLVMAIYDFDRFSKHDIIGE-------------VKVPM- 245
Query: 471 LEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIKGS 530
N G P+ + L ++ L Y T G+L+V +++
Sbjct: 246 -----NTVDLGQPIEEWRDLQGGEKEEPEKLG-----DICTSLRYVPTAGKLTVCILEAK 295
Query: 531 HFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVT 590
+ + + V D Y K+ L+ + G+ + + KT++++ NP + E+F F++ Q+ V
Sbjct: 296 NLKKMDVGGLSDPYVKIHLMQN-GKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQ 354
Query: 591 LMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWHTL 642
++++V + + + E IG I +G N++G E + HW +M + I +WH+L
Sbjct: 355 VVVTVLDYDKLGKNEAIGKIFVGSNATGTELR-HWSDMLANPRRPIAQWHSL 405
Score = 35.0 bits (79), Expect = 0.21
Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 3/81 (3%)
Query: 343 GVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKH-- 400
G E K GD+ Y + KLTV I+ A+ L D G++ V + L+ K
Sbjct: 263 GEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLK 322
Query: 401 RGRTNIQRGP-NPVFREKVTF 420
+ +T +++ NP F E +F
Sbjct: 323 KKKTTVKKKTLNPYFNESFSF 343
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 100 bits (248), Expect = 5e-21
Identities = 78/284 (27%), Positives = 129/284 (45%), Gaps = 28/284 (9%)
Query: 360 YRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQR-GPNPVFREKV 418
Y LTV I++AQ LP KD SG + V + LLP KKH+ T ++R NP + E
Sbjct: 145 YNFQESTLTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETF 204
Query: 419 TFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVTLVLEPRSNIS 478
F V R+ + + +R S P GE+ + L + +
Sbjct: 205 LFEGFPYEKVVQ-----RILYLQVLDYDR--------FSRNDPIGEVSIPLNKVDLTQMQ 251
Query: 479 SGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIKGSHFRNLAVN 538
+ L P SD + G ELL+ L YN + + V +IK + + + +
Sbjct: 252 TFWKDLKPC----SDGS--------GSRGELLLSLCYNPSANSIIVNIIKARNLKAMDIG 299
Query: 539 RAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNR 598
D Y K++L+ + + + KT + NP++ E+F F + +L + T++I+V ++
Sbjct: 300 GTSDPYVKVWLMYK-DKRVEKKKTVTMKRNLNPIFNESFAFDIPTEKLRETTIIITVMDK 358
Query: 599 RTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWHTL 642
+ R ++IG I L SG E HW++M Q + +WH L
Sbjct: 359 DKLSRNDVIGKIYLSW-KSGPGEVKHWKDMIARPRQPVAQWHQL 401
>gi|6005997 double C2-like domains, beta [Homo sapiens]
Length = 412
Score = 99.8 bits (247), Expect = 7e-21
Identities = 85/353 (24%), Positives = 152/353 (43%), Gaps = 27/353 (7%)
Query: 297 RRQSTEGSLE----METAFNSRGFEDSYATDSSSMWSPEEQDRTNLQVPSGVSEPISKCG 352
RR ++G+ E ++ F + G + S P + S+ + G
Sbjct: 69 RRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTALG 128
Query: 353 DLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPG--KKHRGRTNIQRGP 410
LD Y + L TI +A+GL D +G+ V + LLPG K ++ RT R
Sbjct: 129 TLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNT 188
Query: 411 -NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVTL 469
NP + E +T+ + D+ +R + K +GE L L P +
Sbjct: 189 LNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFNI 248
Query: 470 VLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIKG 529
LE + + + +SL G +L+ L Y++ L V +++
Sbjct: 249 CLEKQLPVDK----------------TEDKSLEERG--RILISLKYSSQKQGLLVGIVRC 290
Query: 530 SHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDV 589
+H + N D Y K +L V ++ S+ KT++++ NP + E F +++ L+
Sbjct: 291 AHLAAMDANGYSDPYVKTYLRPDVDKK-SKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKK 349
Query: 590 TLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWHTL 642
+L ++V++ K + IG + LG ++ GE + HW + + K ++I RWHTL
Sbjct: 350 SLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLK-HWFDCLKNKDKRIERWHTL 401
>gi|216548478 synaptotagmin XI [Homo sapiens]
Length = 431
Score = 95.5 bits (236), Expect = 1e-19
Identities = 79/321 (24%), Positives = 152/321 (47%), Gaps = 35/321 (10%)
Query: 329 SPEEQDRTNLQVPSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLP--DKDRSGVN 386
+P E T+ PS E + G L +Y + L VTI A GLP D G +
Sbjct: 140 TPGESKTTS---PSSPEEDVM-LGSLTFSVDYNFPKKALVVTIQEAHGLPVMDDQTQGSD 195
Query: 387 SWQVHVVLLPGKKHRGRTNIQRGP-NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTR 445
+ + + +LP K+HR +T + R +PVF E TF + + + F + + + +R
Sbjct: 196 PY-IKMTILPDKRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSR 254
Query: 446 ERMMGEKLFYLSHLHPE-GEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHG 504
+ ++GE + L+ + P G++++T + R NI + +S G
Sbjct: 255 DDVIGEVMVPLAGVDPSTGKVQLTRDIIKR-NIQ--------------------KCISRG 293
Query: 505 GAPELLVGLSYNATTGRLSVEMIKGSHFRNLAVNR-APDTYGKLFLLNSVGQEMSRCKTS 563
EL V LSY R++V ++K H + + + + Y K+ + + +++ KT
Sbjct: 294 ---ELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGNPYVKVNVYYG-RKRIAKKKTH 349
Query: 564 IRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQD 623
+++ NP++ E+F++ + L D+++ V + + E++G + LG +S +
Sbjct: 350 VKKCTLNPIFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNEVVGRLILGAHSVTASGAE 409
Query: 624 HWEEMKETKGQQICRWHTLLE 644
HW E+ E+ + + +WH+L E
Sbjct: 410 HWREVCESPRKPVAKWHSLSE 430
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 92.8 bits (229), Expect = 9e-19
Identities = 79/306 (25%), Positives = 137/306 (44%), Gaps = 31/306 (10%)
Query: 341 PSGVSEPIS---KCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPG 397
PSG + ++ + G L +Y S +L V I++A GL D G + V V LLP
Sbjct: 96 PSGPGQQVADKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPD 155
Query: 398 KKHRGRTNIQRGP-NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYL 456
K+ R T + R NP F E F K+ ++ + +Y + +R +GE
Sbjct: 156 KRRRYETKVHRQTLNPHFGETFAF-KVPYVELGGRVLVMAVYDFDRFSRNDAIGE----- 209
Query: 457 SHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYN 516
V P S++ G P+ + + L ++ L Y
Sbjct: 210 -------------VRVPMSSVDLG-RPVQAWRELQAAPREEQEKLG-----DICFSLRYV 250
Query: 517 ATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKET 576
T G+L+V +++ + + + V D Y K+ LL G+++ + KT+I++ NP Y E
Sbjct: 251 PTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQG-GKKVRKKKTTIKKNTLNPYYNEA 309
Query: 577 FVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQI 636
F F+V Q+ V + ++V + + + E IG +A+G + G + HW +M + I
Sbjct: 310 FSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLR-HWADMLANPRRPI 368
Query: 637 CRWHTL 642
+WH+L
Sbjct: 369 AQWHSL 374
>gi|40068038 B/K protein [Homo sapiens]
Length = 474
Score = 91.7 bits (226), Expect = 2e-18
Identities = 81/306 (26%), Positives = 138/306 (45%), Gaps = 49/306 (16%)
Query: 352 GDLDVIFEYRAASQKLTVTIVRAQGLPD--------KDRSGVNSWQVHVVLLPGKKHRGR 403
G L +Y LTV ++ A+ LP +D + N + V + LLP +K+ +
Sbjct: 186 GMLHFSTQYDLLHNHLTVRVIEARDLPPPISHDGSRQDMAHSNPY-VKICLLPDQKNSKQ 244
Query: 404 TNIQRGPN-PVFREKVTFA----KLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSH 458
T ++R PVF E+ TF + + R + V F K +R ++G
Sbjct: 245 TGVKRKTQKPVFEERYTFEIPFLEAQRRTLLLTVVDFD-----KFSRHCVIG-------- 291
Query: 459 LHPEGEMKVTLVLEPRSNISSGG--SPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYN 516
KV++ L + G L PS+ + + ELL+ L+Y
Sbjct: 292 -------KVSVPLCEVDLVKGGHWWKALIPSSQNEVE------------LGELLLSLNYL 332
Query: 517 ATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKET 576
+ GRL+V++I+ V++ D + K+ L++ + ++ KTS RG +P Y E+
Sbjct: 333 PSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTK-KTSFLRGTIDPFYNES 391
Query: 577 FVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQI 636
F F+V +L + +L+ +V+ + IG I +GQ SSG E +HW M T +
Sbjct: 392 FSFKVPQEELENASLVFTVFGHNMKSSNDFIGRIVIGQYSSGPSETNHWRRMLNTHRTAV 451
Query: 637 CRWHTL 642
+WH+L
Sbjct: 452 EQWHSL 457
Score = 31.2 bits (69), Expect = 3.1
Identities = 31/140 (22%), Positives = 60/140 (42%), Gaps = 10/140 (7%)
Query: 493 DSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIKG-------SHFRNLAVNRAPDTYG 545
DS + + LS L Y+ L+V +I+ SH + + Y
Sbjct: 172 DSLTDEEILSKYQLGMLHFSTQYDLLHNHLTVRVIEARDLPPPISHDGSRQDMAHSNPYV 231
Query: 546 KLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKE 605
K+ LL Q+ S+ +T ++R PV++E + F++ + TL+++V + R
Sbjct: 232 KICLLPD--QKNSK-QTGVKRKTQKPVFEERYTFEIPFLEAQRRTLLLTVVDFDKFSRHC 288
Query: 606 MIGWIALGQNSSGEEEQDHW 625
+IG +++ + HW
Sbjct: 289 VIGKVSVPLCEVDLVKGGHW 308
>gi|239744413 PREDICTED: hypothetical protein LOC390213 [Homo
sapiens]
Length = 431
Score = 84.0 bits (206), Expect = 4e-16
Identities = 78/305 (25%), Positives = 138/305 (45%), Gaps = 14/305 (4%)
Query: 341 PSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPG--K 398
P G S+ + G L+ + A + L T RA+GL +++ V LLPG K
Sbjct: 129 PEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSADAY-VKANLLPGASK 187
Query: 399 KHRGRTNIQRGPN-PVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLS 457
+ RT+ RG PV+ E +T+ +D +R L + + M ++ +
Sbjct: 188 ASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAP 247
Query: 458 HLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNA 517
L GE++V L + S L + ++ + + H +L+ L Y++
Sbjct: 248 SL---GELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGH-----VLLSLCYSS 299
Query: 518 TTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETF 577
G L V +++ +H + N D + +LFL + G++ S+ KTS+ R NP + E F
Sbjct: 300 QQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKK-SKFKTSVHRKTLNPEFNEEF 358
Query: 578 VFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQIC 637
+ +L+ TL++SV++ + IG + LG ++SGE + HW E ++
Sbjct: 359 FYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLR-HWLECLGHSDHRLK 417
Query: 638 RWHTL 642
WH L
Sbjct: 418 LWHPL 422
>gi|31881675 synaptotagmin XV isoform a [Homo sapiens]
Length = 421
Score = 72.4 bits (176), Expect = 1e-12
Identities = 76/313 (24%), Positives = 134/313 (42%), Gaps = 36/313 (11%)
Query: 333 QDRTNLQVPSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHV 392
+D++ P G G L EY +++L V +++AQ L + S S V +
Sbjct: 136 EDKSETDFPDGC------LGRLWFSVEYEQEAERLLVGLIKAQHL--QAPSETCSPLVKL 187
Query: 393 VLLPGKKHRGRTNIQRGP-NPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGE 451
LLP ++ ++ +R NP F E F ++ + + ++F +Y + + +++G+
Sbjct: 188 YLLPDERRFLQSKTKRKTSNPQFDEHFIF-QVSSKTITQRVLKFSVYHVDRQRKHQLLGQ 246
Query: 452 KLFYLSHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLV 511
LF L + TLV + R + S + S G +L
Sbjct: 247 VLFPLKN--------ETLVGDCRR------------VIWRDLEAESLEPPSEFG--DLQF 284
Query: 512 GLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCK-TSIRRGQPN 570
LSYN RL+V +++ R + K+ L+N + +CK TS G N
Sbjct: 285 CLSYNDYLSRLTVVVLRAKGLRLQEDRGIVSVFVKVSLMNH--NKFVKCKKTSAVLGSIN 342
Query: 571 PVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNS-SGEEEQDHWEEMK 629
PVY ETF F+ +L +L ++V + + +G + +G + E +HW+EM
Sbjct: 343 PVYNETFSFKADATELDTASLSLTVVQNMEGDKSQQLGRVVVGPYMYTRGRELEHWDEML 402
Query: 630 ETKGQQICRWHTL 642
+ + RWH L
Sbjct: 403 SKPKELVKRWHAL 415
Score = 39.3 bits (90), Expect = 0.011
Identities = 35/140 (25%), Positives = 59/140 (42%), Gaps = 13/140 (9%)
Query: 478 SSGG-------SPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIKGS 530
SSGG ++P + S T G L + Y RL V +IK
Sbjct: 114 SSGGLGDACMVGAINPELYKFPEDKSETD-FPDGCLGRLWFSVEYEQEAERLLVGLIKAQ 172
Query: 531 HFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVT 590
H + + +P KL+LL E ++ +R NP + E F+FQV+ ++
Sbjct: 173 HLQAPSETCSPLV--KLYLLPD---ERRFLQSKTKRKTSNPQFDEHFIFQVSSKTITQRV 227
Query: 591 LMISVYNRRTMKRKEMIGWI 610
L SVY+ ++ +++G +
Sbjct: 228 LKFSVYHVDRQRKHQLLGQV 247
>gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens]
Length = 451
Score = 65.9 bits (159), Expect = 1e-10
Identities = 40/134 (29%), Positives = 71/134 (52%), Gaps = 2/134 (1%)
Query: 509 LLVGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQ 568
+L+ L Y++ G L V +++ +H + N D + +LFL + G++ S+ KTS+ R
Sbjct: 311 VLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKK-SKFKTSVHRKT 369
Query: 569 PNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEM 628
NP + E F + +L+ TL++SV++ + IG + LG ++SGE + HW E
Sbjct: 370 LNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLR-HWLEC 428
Query: 629 KETKGQQICRWHTL 642
++ WH L
Sbjct: 429 LGHSDHRLELWHPL 442
Score = 32.3 bits (72), Expect = 1.4
Identities = 37/132 (28%), Positives = 57/132 (43%), Gaps = 7/132 (5%)
Query: 341 PSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPG--K 398
P G S+ + G L+ + A + L T RA+GL SG V LLPG K
Sbjct: 75 PEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASK 133
Query: 399 KHRGRTNIQRGPN-PVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLS 457
+ RT+ RG PV+ E +T+ +D +R L + + M ++ +
Sbjct: 134 ASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAP 193
Query: 458 HLHPEGEMKVTL 469
L GE++V L
Sbjct: 194 SL---GELRVPL 202
>gi|169203543 PREDICTED: similar to hCG21066 [Homo sapiens]
Length = 451
Score = 65.9 bits (159), Expect = 1e-10
Identities = 40/134 (29%), Positives = 71/134 (52%), Gaps = 2/134 (1%)
Query: 509 LLVGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQ 568
+L+ L Y++ G L V +++ +H + N D + +LFL + G++ S+ KTS+ R
Sbjct: 311 VLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKK-SKFKTSVHRKT 369
Query: 569 PNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEM 628
NP + E F + +L+ TL++SV++ + IG + LG ++SGE + HW E
Sbjct: 370 LNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLR-HWLEC 428
Query: 629 KETKGQQICRWHTL 642
++ WH L
Sbjct: 429 LGHSDHRLELWHPL 442
Score = 32.3 bits (72), Expect = 1.4
Identities = 37/132 (28%), Positives = 57/132 (43%), Gaps = 7/132 (5%)
Query: 341 PSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPG--K 398
P G S+ + G L+ + A + L T RA+GL SG V LLPG K
Sbjct: 75 PEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASK 133
Query: 399 KHRGRTNIQRGPN-PVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLS 457
+ RT+ RG PV+ E +T+ +D +R L + + M ++ +
Sbjct: 134 ASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAP 193
Query: 458 HLHPEGEMKVTL 469
L GE++V L
Sbjct: 194 SL---GELRVPL 202
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.127 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,826,341
Number of Sequences: 37866
Number of extensions: 1141857
Number of successful extensions: 3810
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 3459
Number of HSP's gapped (non-prelim): 289
length of query: 645
length of database: 18,247,518
effective HSP length: 109
effective length of query: 536
effective length of database: 14,120,124
effective search space: 7568386464
effective search space used: 7568386464
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.