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Search of human proteins with 32698688
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32698688 citron [Homo sapiens]
(2027 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32698688 citron [Homo sapiens] 3997 0.0
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 436 e-121
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 433 e-121
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 407 e-113
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 405 e-112
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 404 e-112
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 392 e-108
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 335 3e-91
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 335 3e-91
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 331 5e-90
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 317 6e-86
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 192 3e-48
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 188 4e-47
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 188 4e-47
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 188 4e-47
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 188 4e-47
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 188 4e-47
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 186 3e-46
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 185 3e-46
gi|28557781 protein kinase C, eta [Homo sapiens] 184 8e-46
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 181 8e-45
gi|4502023 AKT2 kinase [Homo sapiens] 180 1e-44
gi|4826948 protein kinase, X-linked [Homo sapiens] 180 1e-44
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 180 1e-44
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 180 1e-44
gi|148727255 microtubule associated serine/threonine kinase fami... 178 5e-44
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 177 7e-44
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 177 7e-44
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 177 9e-44
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 177 9e-44
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 3997 bits (10367), Expect = 0.0
Identities = 2027/2027 (100%), Positives = 2027/2027 (100%)
Query: 1 MLKFKYGARNPLDAGAAEPIASRASRLNLFFQGKPPFMTQQQMSPLSREGILDALFVLFE 60
MLKFKYGARNPLDAGAAEPIASRASRLNLFFQGKPPFMTQQQMSPLSREGILDALFVLFE
Sbjct: 1 MLKFKYGARNPLDAGAAEPIASRASRLNLFFQGKPPFMTQQQMSPLSREGILDALFVLFE 60
Query: 61 ECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATG 120
ECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATG
Sbjct: 61 ECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATG 120
Query: 121 DIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGG 180
DIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGG
Sbjct: 121 DIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGG 180
Query: 181 DLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDF 240
DLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDF
Sbjct: 181 DLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDF 240
Query: 241 GSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGR 300
GSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGR
Sbjct: 241 GSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGR 300
Query: 301 SPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEGLCCHPFF 360
SPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEGLCCHPFF
Sbjct: 301 SPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEGLCCHPFF 360
Query: 361 SKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFS 420
SKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFS
Sbjct: 361 SKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFS 420
Query: 421 YSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVS 480
YSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVS
Sbjct: 421 YSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVS 480
Query: 481 EVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH 540
EVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH
Sbjct: 481 EVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH 540
Query: 541 DIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK 600
DIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK
Sbjct: 541 DIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK 600
Query: 601 RKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQ 660
RKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQ
Sbjct: 601 RKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQ 660
Query: 661 NIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQH 720
NIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQH
Sbjct: 661 NIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQH 720
Query: 721 YEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQR 780
YEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQR
Sbjct: 721 YEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQR 780
Query: 781 IVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI 840
IVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI
Sbjct: 781 IVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI 840
Query: 841 SHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAAL 900
SHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAAL
Sbjct: 841 SHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAAL 900
Query: 901 ESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDN 960
ESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDN
Sbjct: 901 ESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDN 960
Query: 961 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCT 1020
AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCT
Sbjct: 961 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCT 1020
Query: 1021 MLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ 1080
MLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ
Sbjct: 1021 MLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ 1080
Query: 1081 RITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQ 1140
RITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQ
Sbjct: 1081 RITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQ 1140
Query: 1141 KLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEN 1200
KLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEN
Sbjct: 1141 KLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEN 1200
Query: 1201 IQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNE 1260
IQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNE
Sbjct: 1201 IQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNE 1260
Query: 1261 LKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIV 1320
LKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIV
Sbjct: 1261 LKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIV 1320
Query: 1321 RSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCL 1380
RSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCL
Sbjct: 1321 RSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCL 1380
Query: 1381 DTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEP 1440
DTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEP
Sbjct: 1381 DTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEP 1440
Query: 1441 SSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDG 1500
SSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDG
Sbjct: 1441 SSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDG 1500
Query: 1501 DVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALES 1560
DVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALES
Sbjct: 1501 DVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALES 1560
Query: 1561 VVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLK 1620
VVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLK
Sbjct: 1561 VVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLK 1620
Query: 1621 NSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPN 1680
NSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPN
Sbjct: 1621 NSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPN 1680
Query: 1681 IFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFT 1740
IFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFT
Sbjct: 1681 IFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFT 1740
Query: 1741 NYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEY 1800
NYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEY
Sbjct: 1741 NYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEY 1800
Query: 1801 LLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGT 1860
LLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGT
Sbjct: 1801 LLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGT 1860
Query: 1861 PARAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSS 1920
PARAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSS
Sbjct: 1861 PARAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSS 1920
Query: 1921 PNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELRRDKSPGRPLEREK 1980
PNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELRRDKSPGRPLEREK
Sbjct: 1921 PNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELRRDKSPGRPLEREK 1980
Query: 1981 SPGRMLSTRRERSPGRLFEDSSRGRLPAGAVRTPLSQVNKVWDQSSV 2027
SPGRMLSTRRERSPGRLFEDSSRGRLPAGAVRTPLSQVNKVWDQSSV
Sbjct: 1981 SPGRMLSTRRERSPGRLFEDSSRGRLPAGAVRTPLSQVNKVWDQSSV 2027
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 436 bits (1120), Expect = e-121
Identities = 330/1195 (27%), Positives = 592/1195 (49%), Gaps = 115/1195 (9%)
Query: 32 QGKPPFMTQQQMSPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQ 91
Q K + + SP++ E +LD L L + PAL K K++ NF+ +Y + +++ LQ
Sbjct: 27 QRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQ 86
Query: 92 PSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSR 151
A+D++V ++G G F EVQ+VR KA+ +YAMK++ K ++ + +FF EER+I++
Sbjct: 87 MKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAF 146
Query: 152 STSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHS 211
+ SPW+ QL YAFQD +LY+VMEY PGGDL++L++ Y+ + E +FY AE++LA+ +
Sbjct: 147 ANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDA 204
Query: 212 VHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTV 271
+H MG +HRD+KP+N+L+D+ GH+KL DFG+ KM+ MV+ +GTPDY++PEVL
Sbjct: 205 IHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKS 264
Query: 272 MNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVS 331
GD G YG +CDWWSVGV YEM+ G +PF + T++ IM+ + L FP+D ++S
Sbjct: 265 QGGD--GFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEIS 322
Query: 332 SDFLDLIQSLLCGQKERLKFEG---LCCHPFF--SKIDWNNIRNSPPPFVPTLKSDDDTS 386
+LI + L ++ RL G + HPFF + W+NIR + P VP L SD D+S
Sbjct: 323 KHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSS 382
Query: 387 NFDEPEKNSW-VSSSPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTS 445
NFD+ E + V + P P F G +LPF+GF+Y R ++S S +T
Sbjct: 383 NFDDIEDDKGDVETFPI---PKAFVGNQLPFIGFTYY-------RENLLLSDSPSCRETD 432
Query: 446 SMEKKLLIKSKELQDSQDKCHKMEQEMT-------RLHRRVSEVEAVLSQKEVELKASET 498
S++ + K++E Q+ Q K + +E+ ++ L ++ V L + EL+ T
Sbjct: 433 SIQSR---KNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEIT 489
Query: 499 QRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQ 558
R +E L E + L+ + + + E DK L +D+ +L+++K++
Sbjct: 490 LRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQN 549
Query: 559 AQV--EEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQ 616
+Q+ E++ + QL+E R SD A ++ E ++ + +
Sbjct: 550 SQISTEKVNQLQRQLDETNALLRTESD-----------TAARLRKTQAESSKQIQQLESN 598
Query: 617 GKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKL 676
+ + LE + + + LQ LE + T +E++ +++ E +L
Sbjct: 599 NRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDL--- 655
Query: 677 QNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEV----HLKQKEQHYEEKIKVLDNQI 732
++ + K +E +L+E+ + + ++E+ LK +Q E++ +
Sbjct: 656 ---KNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQE-EAEHKAT 711
Query: 733 KKDLADKETL-ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLA 791
K LADK + E++ + E E K L E++ + +++ + E+R L K
Sbjct: 712 KARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLK-- 769
Query: 792 ANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRL 851
S +K ++ + ++R +E + K L+ Q ++++ S+K +L
Sbjct: 770 -QSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEK-QL 827
Query: 852 LELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 911
+ L E+ + E+Q EL+++ + ++E + QL A Q ++Q+R+ K E
Sbjct: 828 KQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEEC 887
Query: 912 EETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLS 971
EE T +E L + E+Q + D+L + LT+ ++E L+
Sbjct: 888 EEKTKLGKE----LQQKKQELQDERDSLAAQLEI---------TLTKADSE------QLA 928
Query: 972 KQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEA 1031
+ + E ++ E ++ E++ ++ + + +LT + T+ +L+ T L V +L
Sbjct: 929 RSIAEEQYSDLEKEKIMKELE-IKEMMARHKQELTEKDATIASLEETNRTLTSDVANLAN 987
Query: 1032 LNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVEL 1091
+EL K + + S L DE+ + ++ L TE+ + +A ++
Sbjct: 988 EKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKL--------- 1038
Query: 1092 AVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERE-LKQ 1150
AEI+ ++ +K + ND + + E R L +L++ERE L Q
Sbjct: 1039 ------AEIMNRKEPVK-----------RGNDTDVRRK--EKENRKLHMELKSEREKLTQ 1079
Query: 1151 RLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLY 1205
++++ Q +L +M Q ++ LQ LD D SD+E +Q L+
Sbjct: 1080 QMIKYQKEL-NEMQAQIAEESQIRIELQMTLDSKD------SDIEQLRSQLQALH 1127
Score = 102 bits (253), Expect = 5e-21
Identities = 182/873 (20%), Positives = 355/873 (40%), Gaps = 137/873 (15%)
Query: 660 QNIRQAKERAERELEKLQNRE-DSSEGIRKKLVEAEELEEKHREAQVSAQH----LEVHL 714
+N+ + + RE + +Q+R+ + S+ I+KKL EE +A+ + + L
Sbjct: 418 ENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRL 477
Query: 715 KQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI 774
++ + EE+I L ++ L E + ++Q E K +++K +++ +
Sbjct: 478 EKTAKELEEEI-TLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKK---RNLENDV 533
Query: 775 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEM--ISELRQQKFYLETQAGKLEAQNRK 832
SL+ ++ +L + N+ NS + T++ + Q ++ + L + + + K +A++ K
Sbjct: 534 NSLKDQLEDLKKRNQ---NSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSK 590
Query: 833 LEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTA 892
+QLE +++D DKN LL E KL+L+++ LQ +L+ T
Sbjct: 591 QIQQLES-NNRDLQDKNCLL-------------ETAKLKLEKEFINLQSALESERRDRTH 636
Query: 893 -------LQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKF-DALRNSCT 944
LQ LE L+ K L + E + ++Q +F D +
Sbjct: 637 GSEIINDLQGRICGLEEDLKNGKILLAKVELE-----------KRQLQERFTDLEKEKSN 685
Query: 945 VITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQ 1004
+ D+ QL + + + ++ +L + + + I + +SE +E+ ++ ++
Sbjct: 686 MEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEA---MKEMEKKLLE 742
Query: 1005 LTSQKQTMEAL----KTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECR 1060
+ KQ +E L + C++L+ + + +ELL++ + VL ++
Sbjct: 743 ERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQ-------KDVLNED------- 788
Query: 1061 VRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDK 1120
VR L ++ E Q R + Q V +K + ++ L E K+ E +
Sbjct: 789 VRNLTLKIEQETQKRCLTQNDLKMQTQQVN-TLKMSEKQLKQENNHLMEMKMNLEKQNA- 846
Query: 1121 LNDLEKKHAMLEMNARSLQQKLETE-----------RELKQRLLEEQAKLQQQMDLQKNH 1169
+L K+ + + LQ +LE E RELK+ EE+ KL +++ +K
Sbjct: 847 --ELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEEC-EEKTKLGKELQQKKQE 903
Query: 1170 IF----RLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDF 1225
+ L L+ L +AD + RS E Q +++ EK+ E I +
Sbjct: 904 LQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLE----KEKIMKELEIKE------- 952
Query: 1226 LQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIE 1285
+ A+ Q +K + +E T L + LA EKE EL L+ + +
Sbjct: 953 MMARHKQELTEKDATIASLEE-----TNRTLTSDVANLANEKE-----ELNNKLKDVQEQ 1002
Query: 1286 LRSAREE---AAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKE 1342
L ++E AA KA T T + Q A++ LA +R++
Sbjct: 1003 LSRLKDEEISAAAIKAQFEKQLLTERTLKTQ---------------AVNKLAEIMNRKEP 1047
Query: 1343 SSTPEEFSRRLKERMHHNIPHRFNVG---LNMRATKCAVCLDTVH--FGRQASKCLECQV 1397
+ R KE+ + + L + K L+ + ++ +E Q+
Sbjct: 1048 VKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQM 1107
Query: 1398 MCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPG-LQTKEPSSSLHLEGWMKVPRNN 1456
K S L A + + + + PG + + LEGW+ +P N
Sbjct: 1108 TLDSKDSDIEQLRSQLQALHIGLDSSSIG----SGPGDAEADDGFPESRLEGWLSLPVRN 1163
Query: 1457 KRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRP 1489
+ GW +KY+++ K+L YD+E + P
Sbjct: 1164 NTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNP 1196
Score = 77.0 bits (188), Expect = 2e-13
Identities = 111/514 (21%), Positives = 226/514 (43%), Gaps = 69/514 (13%)
Query: 456 KELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKAS-ETQRSLLEQDLATY---- 510
++L++ + K+E E +L R +++E S E+++ + + LEQ+ A +
Sbjct: 653 EDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATK 712
Query: 511 --ITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMM 568
+ + + + S+E+A+ E +E +K L ++++ L + E E + + + L
Sbjct: 713 ARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENL--LLEAEKRCSLLDCDLKQ 770
Query: 569 NQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLE 628
+Q + + ++ D+ ++R L E+ +K Q+ L Q V E
Sbjct: 771 SQ--QKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQ----VNTLKMSE 824
Query: 629 KINAEQQLKIQELQEKLEKA-VKASTEATELLQNIRQAKERAERE-----LEKLQNREDS 682
K ++ + E++ LEK + E + +++ +++ E E L K Q RE
Sbjct: 825 KQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELK 884
Query: 683 SEGIRKKLVEAEELEEKHREAQVS----AQHLEVHLKQKEQHY------EEKIKVLDNQ- 731
E +K +EL++K +E Q A LE+ L + + EE+ L+ +
Sbjct: 885 EE-CEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEK 943
Query: 732 IKKDLADKETLENMMQRHEEEAHEK----------GKILSEQKAMI----NAMDSKIRSL 777
I K+L KE MM RH++E EK + L+ A + +++K++ +
Sbjct: 944 IMKELEIKE----MMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDV 999
Query: 778 EQRIVELSEANKLAA------NSSLFTQRNMKAQE-----EMISELRQQKFYLETQAGKL 826
++++ L + AA L T+R +K Q E+++ K +T +
Sbjct: 1000 QEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRK 1059
Query: 827 EAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQER 886
E +NRKL +L+ S++ +L + + ++ E + Q E + ELQ++L +
Sbjct: 1060 EKENRKLHMELK-------SEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSK 1112
Query: 887 ESQLTALQAARAALESQLRQAKTELEETTAEAEE 920
+S + L++ AL L + AEA++
Sbjct: 1113 DSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADD 1146
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 433 bits (1113), Expect = e-121
Identities = 331/1165 (28%), Positives = 588/1165 (50%), Gaps = 145/1165 (12%)
Query: 44 SPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLV 103
S ++ + +LD L L + PAL K K++ NF+ +Y DTI ++++L+ A+D+EV ++
Sbjct: 23 SEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVI 82
Query: 104 GCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYA 163
G G F EVQ+VR K+T +YAMK++ K ++ + +FF EER+I++ + SPW+ QL YA
Sbjct: 83 GRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYA 142
Query: 164 FQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIK 223
FQD +LY+VMEY PGGDL++L++ Y+ + E +FY AE++LA+ ++H MG++HRD+K
Sbjct: 143 FQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMGFIHRDVK 200
Query: 224 PENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLD 283
P+N+L+D++GH+KL DFG+ KMN MV +GTPDY++PEVL GD G YG +
Sbjct: 201 PDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGD--GYYGRE 258
Query: 284 CDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLC 343
CDWWSVGV YEM+ G +PF + T++ IMN + L FPDD +S + +LI + L
Sbjct: 259 CDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLT 318
Query: 344 GQKERLKFEG---LCCHPFFSKID--WNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVS 398
++ RL G + H FF W +R++ P VP L SD DTSNFD+ E++
Sbjct: 319 DREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDK--G 376
Query: 399 SSPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKEL 458
P F G +LPFVGF+Y + S + +TSS K L
Sbjct: 377 EEETFPIPKAFVGNQLPFVGFTY------YSNRRYLSSANPNDNRTSSN------ADKSL 424
Query: 459 QDS-QDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSL 517
Q+S Q +K+E+++ + E+E ++L + + E +
Sbjct: 425 QESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKL-----------DKIMKELDEEGNQ 473
Query: 518 KRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVE-EMRLMMNQLEEDLV 576
+R+LE VSQ + + + L H I E RK ++ E E + VE E+ + +QLE+
Sbjct: 474 RRNLEST---VSQIEKEKMLLQHRINEYQRKAEQ--ENEKRRNVENEVSTLKDQLED--- 525
Query: 577 SARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQL 636
+ + S+LA E K ++ Q +L +A D + E +L K + E
Sbjct: 526 --------LKKVSQNSQLANE----KLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSK 573
Query: 637 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEEL 696
I +L E L + ++ E +L+N + ++ +L+ + E G +++ +L
Sbjct: 574 SISQL-ESLNRELQ---ERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMI--GDL 627
Query: 697 EEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD------NQIKKDLADKETLENMMQRHE 750
+ + Q +HL+ +L++ E +E +L+ N ++ DL K L+++ QR E
Sbjct: 628 QARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYK--LKSLQQRLE 685
Query: 751 EEAHE----KGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQE 806
+E +E K ++ + +++ A + +E+++ E EA + A N + ++ +
Sbjct: 686 QEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLD 745
Query: 807 EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHE 866
+L+Q + LE G E ++E++++ ++ Q + N+ L L+ L+ + E +
Sbjct: 746 ---VDLKQSQQKLEHLTGNKE----RMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEAD 798
Query: 867 EQK-------------LELKRQLTELQLS------------LQERESQLTALQAARAALE 901
K LE KR L E +L+ ++E + QL A Q +
Sbjct: 799 NLKGLEKQMKQEINTLLEAKR-LLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYK 857
Query: 902 SQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNA 961
+Q+++ K E+EE E ++IQ L ++ + + D + + + + QL
Sbjct: 858 TQVKELKEEIEEKNRENLKKIQELQNEKETLATQLD--------LAETKAESEQLA--RG 907
Query: 962 ELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTM 1021
L Q F L+++ +A+ N R+EIT+++ T+ L+ +M
Sbjct: 908 LLEEQYFELTQESKKAASRN-------------RQEITDKD-------HTVSRLEEANSM 947
Query: 1022 LEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQR 1081
L + + L N+EL EK ++ E + +++ + ++ ++TE+ + +A +
Sbjct: 948 LTKDIEILRRENEELTEKMKKAEEEYKL--EKEEEISNLKAAFEKNINTERTLKTQAVNK 1005
Query: 1082 ITESRQVVELAVKEHKAEILALQQALKEQK---LKAESLSDKLNDLEKKH--AMLEMNAR 1136
+ E + + KA L++ KE + L+ +K N + KH + +M A+
Sbjct: 1006 LAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQ 1065
Query: 1137 SLQQKLETERELKQRLLEEQAKLQQ 1161
L ++ EL+ +L +++ ++Q
Sbjct: 1066 -LVEECAHRNELQMQLASKESDIEQ 1089
Score = 105 bits (263), Expect = 3e-22
Identities = 145/705 (20%), Positives = 302/705 (42%), Gaps = 96/705 (13%)
Query: 624 YAKLEKINAEQQLKIQELQE------KLEKAVKASTEATELLQNIRQAKERAERELEKLQ 677
Y E+++ E QLK + Q+ KL+K +K E +N+ + E+E LQ
Sbjct: 433 YKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQ 492
Query: 678 NREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLK------QKEQHYEEKIKVLDNQ 731
+R I + +AE+ EK R + L+ L+ Q Q EK+ L Q
Sbjct: 493 HR------INEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQ 546
Query: 732 IKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLA 791
+ E ++++ + A K +E I+ ++S R L++R N++
Sbjct: 547 L-------EEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQER-------NRIL 592
Query: 792 ANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRL 851
NS T ++ + ++ R+ + + G L+A+ L+E+++ + H +
Sbjct: 593 ENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGER 652
Query: 852 LELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 911
E + L E +++L +L LQ L++ ++ +A + +AK+
Sbjct: 653 KEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSV- 711
Query: 912 EETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI-TDL---EEQLNQLTEDNAELNNQN 967
E E++++ R++ + + + C+++ DL +++L LT + + ++
Sbjct: 712 --AMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEV 769
Query: 968 FYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVM 1027
L+ QL++ S + L++E L+ + E + +KQ + + T
Sbjct: 770 KNLTLQLEQESNKR---LLLQNE---LKTQAFEADNLKGLEKQMKQEINT---------- 813
Query: 1028 DLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQ 1087
LLE +R E + L + E ++RELQ L+ E+ ++ E ++
Sbjct: 814 --------LLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKE 865
Query: 1088 VVELAVKE---------HKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSL 1138
+E +E ++ E LA Q L E K ++E L+ L LE+++ L ++
Sbjct: 866 EIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGL--LEEQYFELTQESKKA 923
Query: 1139 ----QQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDL 1194
+Q++ + RL E + L + +++ + LT+ +++A + L K E
Sbjct: 924 ASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEE---- 979
Query: 1195 EYQLENIQVLYSHEKVKMEGTISQQ--TKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPT 1252
++ N++ + + + E T+ Q KL + + K + +KK RK++
Sbjct: 980 --EISNLKAAF-EKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEK---- 1032
Query: 1253 QVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAR-EEAAHR 1296
+ +L+L L +E+ + ++ QK ++++ EE AHR
Sbjct: 1033 ----ENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHR 1073
Score = 89.4 bits (220), Expect = 3e-17
Identities = 111/529 (20%), Positives = 235/529 (44%), Gaps = 64/529 (12%)
Query: 788 NKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSD 847
N+ ++N+ Q +++ + E + L+ + +E + R +L+KI + +
Sbjct: 414 NRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDE---MEQKCRTSNIKLDKIMKELDEE 470
Query: 848 KNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 907
N+ LE+ + ++ E++K+ L+ ++ E Q ++ + ++ + L+ QL
Sbjct: 471 GNQRRNLESTVSQI----EKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDL 526
Query: 908 KTELEETTAEAEEEIQALTAHRDEIQRKFDALRN-SCTVI------TDLEEQLNQLTEDN 960
K ++ + + A E++ L +E D LR S T + T++ + ++QL N
Sbjct: 527 K-KVSQNSQLANEKLSQLQKQLEEAN---DLLRTESDTAVRLRKSHTEMSKSISQLESLN 582
Query: 961 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCT 1020
EL +N L + S + + QL++ ++ RR+ + + L+ T
Sbjct: 583 RELQERNRILE---NSKSQTDKDYYQLQAILEAERRDRGH-------DSEMIGDLQARIT 632
Query: 1021 MLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQ------FECRVRELQRMLDTEKQS 1074
L+E+V L+ N E +E ER+ EA + EK + +++ LQ+ L+ E
Sbjct: 633 SLQEEVKHLKH-NLEKVEGERK-EAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNE 690
Query: 1075 RARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMN 1134
R+T+ Q +E A E +++ LKE++ E +++ +EK+ +ML+++
Sbjct: 691 HKVTKARLTDKHQSIEEAKSVAMCE---MEKKLKEEREAREKAENRVVQIEKQCSMLDVD 747
Query: 1135 ARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDL 1194
+ QQKLE K+R+ +E L Q++ + N L L+ AD LK +
Sbjct: 748 LKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQM 807
Query: 1195 EYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKG----LFSRRKEDPAL 1250
+ ++ T+ + +L++F A++ + + +G L + + +
Sbjct: 808 KQEI---------------NTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYF 852
Query: 1251 PTQVPLQYNELKLALEKEKARCAELEEALQK------TRIELRSAREEA 1293
T Q ELK +E++ + + LQ T+++L + E+
Sbjct: 853 STLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAES 901
Score = 48.5 bits (114), Expect = 7e-05
Identities = 48/240 (20%), Positives = 102/240 (42%), Gaps = 32/240 (13%)
Query: 1061 VRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDK 1120
+ +L+ L E Q + +Q+ S ++ +KE L E+ + +L
Sbjct: 432 IYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKE-----------LDEEGNQRRNLEST 480
Query: 1121 LNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEA 1180
++ +EK+ +L+ Q+K E E E ++ + E + L+ Q++ L++
Sbjct: 481 VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLE-----------DLKKV 529
Query: 1181 LDRADLLKTERSDLEYQLENIQVLYSHEK---VKMEGTISQQTKLIDFLQAKMDQPAKKK 1237
+ L + S L+ QLE L E V++ + ++ +K I L++ +++ +++
Sbjct: 530 SQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLES-LNRELQER 588
Query: 1238 KGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRK 1297
+ K +Q Y +L+ LE E+ E + + + S +EE H K
Sbjct: 589 NRILENSK------SQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLK 642
Score = 40.8 bits (94), Expect = 0.014
Identities = 14/44 (31%), Positives = 25/44 (56%)
Query: 1446 LEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRP 1489
+EGW+ VP + GW ++Y+V+ K+L Y++E + P
Sbjct: 1121 IEGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNP 1164
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 407 bits (1047), Expect = e-113
Identities = 288/958 (30%), Positives = 482/958 (50%), Gaps = 71/958 (7%)
Query: 44 SPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLV 103
S LS E +LD L L+ ECS AL + K+V+ F+ ++E+Q +DFE+ ++
Sbjct: 23 SALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVI 82
Query: 104 GCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYA 163
G G F EV VV+ K T IYAMK++ K +L + + + F EER++L WI L YA
Sbjct: 83 GRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYA 142
Query: 164 FQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIK 223
FQD+NHLYLVM+Y GGDLL+LL+++ED+L E++ +FY+ E++LA+ S+H + YVHRDIK
Sbjct: 143 FQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIK 202
Query: 224 PENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLD 283
P+N+L+D GHI+L DFGS KMN + V + + +GTPDY++PE+L M DG G YG +
Sbjct: 203 PDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAME-DGMGKYGPE 261
Query: 284 CDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDD-PKVSSDFLDLIQSLL 342
CDWWS+GV YEM+YG +PF + T+ IMN + +FP VS + DLIQ L+
Sbjct: 262 CDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLI 321
Query: 343 CGQKERLKFEGL---CCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSS 399
C ++ RL G+ H FF ++W NIRN P++P + S DTSNFD + +
Sbjct: 322 CSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTE 381
Query: 400 SPCQLSPSGFSGEELPFVGFSYS-----------KAL---GILGRSESVVSGLDSPAKTS 445
S +GFSG LPF+GF+++ K++ L + E V L+ +
Sbjct: 382 ILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQSNTLTKDEDVQRDLEHSLQME 441
Query: 446 SMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQ 505
+ E+++ +E + K + Q + LH + KE++ E +R
Sbjct: 442 AYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSNSNRDKEIKKLNEEIER----- 496
Query: 506 DLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMR 565
L I + + L+R LE + + QE + + Q L + +Q R +++ KE+ ++ VE
Sbjct: 497 -LKNKIADSNRLERQLEDT-VALRQEREDSTQRLRGLEKQHRVVRQEKEELHKQLVEASE 554
Query: 566 LMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYA 625
+ +Q +E L A ++ L E E E + + + +L +++ + +
Sbjct: 555 RLKSQAKE-LKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVD 613
Query: 626 KLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEG 685
+ + + +EL+ +L+ AV +++ +L ++ ++ E ELE L+ ++ G
Sbjct: 614 AMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQ-GGRG 672
Query: 686 IRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENM 745
L +E+ + E + E L ++E + ++K +KK++
Sbjct: 673 AGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVK----NVKKEV--------- 719
Query: 746 MQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEA-----NKLAANSSLFTQR 800
H+ E+H+ L+ QK ++ D +S +R E+ EA +K ++
Sbjct: 720 ---HDSESHQ----LALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDE 772
Query: 801 NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLRE 860
N K L + L + KL AQNR+LE++L+ ++ + S + ++ ++
Sbjct: 773 NKK--------LTAENEKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQW 824
Query: 861 VSLEHEEQKL--ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEA 918
VS E + + L ++TE +L+ L SQ LE +A
Sbjct: 825 VSDEKDARGYLQALASKMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSA-L 883
Query: 919 EEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDE 976
E EI+A ++E+++ DA LE +L N EL + L K+++E
Sbjct: 884 EAEIRAKQLVQEELRKVKDA-------NLTLESKLKDSEAKNRELLEEMEILKKKMEE 934
Score = 159 bits (403), Expect = 2e-38
Identities = 238/1151 (20%), Positives = 473/1151 (41%), Gaps = 104/1151 (9%)
Query: 737 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANS-- 794
+D+ +L+++MQ + E + E + A + +IR LEQ +ELS + + +
Sbjct: 410 SDRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQ 469
Query: 795 SLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK---ISHQDHSDKNRL 851
SL + E+++ +E K+ NR LE QLE + + RL
Sbjct: 470 SLHGSSRALSNSNRDKEIKKLNEEIERLKNKIADSNR-LERQLEDTVALRQEREDSTQRL 528
Query: 852 LELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLT-ALQAARAALE--SQLRQAK 908
LE + R V E EE L +QL E L+ + +L A Q + AL+ S+L +
Sbjct: 529 RGLEKQHRVVRQEKEE----LHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERM 584
Query: 909 TELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNF 968
EL + +++ + +K DA+R L ++L A+L++
Sbjct: 585 AELRAQKQKVSRQLRDKEEEMEVATQKVDAMRQEMRRAEKLRKELE------AQLDDAVA 638
Query: 969 YLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMD 1028
SK+ + + Q+ SE++ L+ + R T + Q + + + LE++V+
Sbjct: 639 EASKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQ--QEISKIKSELEKKVLF 696
Query: 1029 LEALNDELLEKER----QWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITE 1084
E +EL+ +E + + + + D +S +E+ + D ++S+ + E
Sbjct: 697 YE---EELVRREASHVLEVKNVKKEVHDSESHQLALQKEILMLKDKLEKSKRERHNEMEE 753
Query: 1085 SRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET 1144
+ ++ + +A + + L + K S DKL ++ LE + L K E+
Sbjct: 754 AVGTIKDKYERERAMLFDENKKLTAENEKLCSFVDKLT---AQNRQLEDELQDLAAKKES 810
Query: 1145 ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALD--RADLLKTERSDLEYQLENIQ 1202
+ ++ E + + D + ++ L + E L+ R+ L + D +++ Q
Sbjct: 811 VAHWEAQIAEIIQWVSDEKDA-RGYLQALASKMTEELEALRSSSLGSRTLDPLWKVRRSQ 869
Query: 1203 VLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELK 1262
L +++++ + + + +Q ++ + L S+ K+ A ++ + LK
Sbjct: 870 KLDMSARLELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILK 929
Query: 1263 LALEKEKARCAELE-EALQKTRIELRSA---------REEAAHRKATDHPHP-STPATAR 1311
+E++ L+ Q + E + R +A + T P P ++P+ +
Sbjct: 930 KKMEEKFRADTGLKLPDFQDSIFEYFNTAPLAHDLTFRTSSASEQETQAPKPEASPSMSV 989
Query: 1312 QQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNM 1371
+ P +PSA+ L P+++ + P+ + H+F++
Sbjct: 990 AASEQQEDMARPPQRPSAVPL---PTTQALALAGPKPKA------------HQFSIKSFS 1034
Query: 1372 RATKCAVCLDT-VHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKM 1430
T+C+ C V RQ C C CH C P C +P E +
Sbjct: 1035 SPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPIPPEQSKR---------- 1084
Query: 1431 NSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYD-NEAREAGQRP 1489
G+ + + + +G +KVP+ ++GW R Y V+ K+ +YD E +
Sbjct: 1085 -PLGVDVQRGIGTAY-KGHVKVPKPTGV-KKGWQRAYAVVCDCKLFLYDLPEGKSTQPGV 1141
Query: 1490 VEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFP 1549
+ L L D + S+ +V AS++ + + D+P I ++ + +L +L +
Sbjct: 1142 IASQVLDLRDDEFSV-SSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENEN 1200
Query: 1550 DKQRWVTALE---SVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVL 1606
+K++WV LE S++ R+ + + +SL ++ + + +D++
Sbjct: 1201 EKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAI----LTAAIVDADRIA- 1255
Query: 1607 VGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSL 1666
VG EEGLY + V ++ + V QI + + ++++ G + L + +
Sbjct: 1256 VGLEEGLYVIEVTRDVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSLDGAE 1315
Query: 1667 AQSHLPAQPDISPNIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRK 1726
+ KGC L ++ C + K +IL Y +K RK
Sbjct: 1316 GSFDIK---------LPETKGCQLMATATLKRNSGTCLFVAVKRLILCYEIQRTKPFHRK 1366
Query: 1727 EIETSEPCS--CIHFTNYSILIGTNKFYEIDMKQYTLE--EFLDKNDHSLAPAVFAASSN 1782
E P S C+ + +G + + Q + ++ ND SLA F + +
Sbjct: 1367 FNEIVAPGSVQCLAVLRDRLCVGYPSGFCLLSIQGDGQPLNLVNPNDPSLA---FLSQQS 1423
Query: 1783 SFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVT 1842
+ V++ S EEYLLCF G++VD GRR+R +L W P+A + ++ V
Sbjct: 1424 FDALCAVELES----EEYLLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVY 1479
Query: 1843 HFNSLEVIEIQ 1853
++V +++
Sbjct: 1480 SEYGVDVFDVR 1490
Score = 38.5 bits (88), Expect = 0.067
Identities = 45/227 (19%), Positives = 99/227 (43%), Gaps = 19/227 (8%)
Query: 439 DSPAKTSSMEKKLLIKSKELQDSQDKCH-KMEQEMTRLHRRVSEVEAVLSQKEVELKASE 497
DS + +++K++L+ +L+ S+ + H +ME+ + + + A+L + +L A
Sbjct: 721 DSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLTAEN 780
Query: 498 TQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQE- 556
+ L +++ + ++ R LE +++ + + I E + + + K+
Sbjct: 781 -------EKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARG 833
Query: 557 -YQAQVEEMRLMMNQLEEDLVSAR--------RRSDLYESELRESRLAAEEFKRKATEC- 606
QA +M + L + +R RRS + R +A E + +A +
Sbjct: 834 YLQALASKMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLV 893
Query: 607 QHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKAST 653
Q +L K KD + E N E +++ L++K+E+ +A T
Sbjct: 894 QEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADT 940
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 405 bits (1040), Expect = e-112
Identities = 254/807 (31%), Positives = 430/807 (53%), Gaps = 44/807 (5%)
Query: 49 EGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHF 108
+G+LD L L E S L + + V+ F+ S +++++EL+ DFE+ ++G G F
Sbjct: 23 DGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKVKELRLQRDDFEILKVIGRGAF 82
Query: 109 AEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKN 168
EV VVR++ TG I+AMK++ K +L + + + F EER++L + S W+ L YAFQD+
Sbjct: 83 GEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEE 142
Query: 169 HLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENIL 228
+LYLVM+Y GGDLL+LL+R+ED+L L QFYLAE++LA+HS+H +GYVHRD+KP+N+L
Sbjct: 143 YLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVL 202
Query: 229 VDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWS 288
+D GHI+L DFGS ++N+N MV++ + +GTPDY++PE+L M +GKG YG CDWWS
Sbjct: 203 LDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAME-EGKGHYGPQCDWWS 261
Query: 289 VGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDD-PKVSSDFLDLIQSLLCGQKE 347
+GV AYE+++G +PF + T+ IMN + L+FP D P V + DLI+ LLC Q+E
Sbjct: 262 LGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEE 321
Query: 348 RLKFEGL---CCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQL 404
RL GL HPFF +DW + +S P++P L+ DTSNFD + +
Sbjct: 322 RLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPP 381
Query: 405 SPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDK 464
S FSG LPFVGF+Y+ SG SP +S L + K
Sbjct: 382 SHGAFSGHHLPFVGFTYT-------------SGSHSPESSSEAWAAL----------ERK 418
Query: 465 CHKMEQEMTRLHRRVSE-VEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQ 523
+EQE L R+ E + A +E+E E Q L L + + +SL ++
Sbjct: 419 LQCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQ--TLRDRLPEMLRDKASLSQTDGP 476
Query: 524 ARMEVSQEDD--KALQLLHDIREQSRKLQEIKEQEY---QAQVEEMRLMMNQLEEDLVSA 578
Q+ D + L LH + R + +EQE Q Q EE+ + + +E +
Sbjct: 477 PAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAAT 536
Query: 579 RRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKI 638
++ S+L E+R A E + + + ++ + + Q + + E ++ + I+ +
Sbjct: 537 ASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNG 596
Query: 639 QELQEKLEKAVKASTEATELLQNIRQA-KERAERELEKLQNREDSSEGIRKKLVEAEELE 697
E + + E L + + QA R + E L ++ + + + E E LE
Sbjct: 597 MGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSR---EQERLE 653
Query: 698 EKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKG 757
+ + Q S Q LE ++ E ++E ++ + + + + + L+ + + EE E
Sbjct: 654 AELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEEL-ESL 712
Query: 758 KILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQ-RNMKAQEEMISELRQQK 816
+ + Q +D + ++ +R+ ++ + +L S+L + R + +E ++++++ +
Sbjct: 713 RNVGTQTLPARPLDHQWKA--RRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQ 770
Query: 817 FYLETQAGKLEAQNRKLEEQLEKISHQ 843
E + + E Q++ L+++L + +
Sbjct: 771 LQAERRLQEAEKQSQALQQELAMLREE 797
Score = 144 bits (362), Expect = 1e-33
Identities = 222/1021 (21%), Positives = 408/1021 (39%), Gaps = 151/1021 (14%)
Query: 896 ARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQ 955
A AALE +L+ + E E + + +E + A T HR+ + LR + L ++L +
Sbjct: 411 AWAALERKLQCLEQEKVELSRKHQEALHAPTDHRE-----LEQLRKE---VQTLRDRLPE 462
Query: 956 LTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEAL 1015
+ D A L+ + +G+ + LR E+D L RE+ E L +Q+Q +
Sbjct: 463 MLRDKASLSQTD-------GPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQEL--- 512
Query: 1016 KTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEK--- 1072
C +Q L+ L E E+E + L + + REL+ + +
Sbjct: 513 ---CRAQGQQEELLQRLQ-EAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQV 568
Query: 1073 -QSRARADQRITESRQVVELAVKEH------------KAEILALQQALKEQKLKAES--- 1116
Q + + +QR+ ES Q + +A++ AL+EQ +A S
Sbjct: 569 TQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRP 628
Query: 1117 --LSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIF--- 1171
+ L L++++ L L+ +L E+E KQRL E+ + + + Q I
Sbjct: 629 SGKEEALCQLQEENRRLSREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWV 688
Query: 1172 ---RLTQGLQEAL--DRADLLKTERS-----------DLEYQLENIQVLYSHEKVKMEGT 1215
++++G +AL A+ L++ R+ D +++ +Q + + +++++
Sbjct: 689 NDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSA 748
Query: 1216 ISQQTKLIDFLQAKMDQ----PAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKAR 1271
+ + + LQ ++ Q + ++ L K+ AL ++ + EL+ +
Sbjct: 749 LEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREELRARGPVDTKP 808
Query: 1272 CAELEEALQKTRIELRSAREEAAHRKATDHP-HPSTPATARQQIAMSAIV-RSPE-HQPS 1328
L L E SA++ +AT H P R+ + M A+ R+P + S
Sbjct: 809 SNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTAS 868
Query: 1329 AMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTV-HFGR 1387
L A P S + P F TKC C + GR
Sbjct: 869 TEGLPAKPGSH---TLRPRSFPS---------------------PTKCLRCTSLMLGLGR 904
Query: 1388 QASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLE 1447
Q C C CH C+ P C +P D + + E + E
Sbjct: 905 QGLGCDACGYFCHTTCAPQAPP-CPVPP------------DLLRTALGVHPETGTGTAYE 951
Query: 1448 GWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDN-EAREAGQRPVEEFELCLPDGDVSIHG 1506
G++ VPR + ++GW R + L S++L++D + R + L L D S
Sbjct: 952 GFLSVPRPSGV-RRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATP 1010
Query: 1507 AVGASELANTAKADVPYILKMESH----PHTTCWPGRTLYLLAPSFPDKQRWVTALESVV 1562
+ AS++ + D+P I ++ + P TTC T+ LLA S +++RW+ L
Sbjct: 1011 VL-ASDVIHAQSRDLPRIFRVTTSQLAVPPTTC----TVLLLAESEGERERWLQVL---- 1061
Query: 1563 AGGRVSREKAEADAKLLGNSLLKLEGDDRLDMN----CTLPFSDQVVLVGTEEGLYALNV 1618
G + R +A + LK D+ L + C + +GTEEGL+ +++
Sbjct: 1062 --GELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHL 1119
Query: 1619 LKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQ-SLAQSHLPAQPDI 1677
N + V V Q+ + L+++ G ++ L + +++ +A + +P
Sbjct: 1120 RSNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPES--- 1176
Query: 1678 SPNIFEAVKGCHLFGAGKIENGL--CICAAMPSKVVILRYNENLSKYCIR-KEIETSEPC 1734
+GC + AG I +C A+ +V+ + + R +E++
Sbjct: 1177 --------RGCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATV 1228
Query: 1735 SCIHFTNYSILIGTNKFYEIDMKQYTL--EEFLDKNDHSLAPAVFAASSNSFPVSIVQVN 1792
+ + +G + + Y L E L P S ++ V
Sbjct: 1229 QSLGLLGDRLCVGAAGGFAL----YPLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVE 1284
Query: 1793 SAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEI 1852
+ E+LL F G++VD GR+SR +L W P+ + Y PYL V NS++V ++
Sbjct: 1285 LS--LSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDV 1342
Query: 1853 Q 1853
+
Sbjct: 1343 R 1343
Score = 64.3 bits (155), Expect = 1e-09
Identities = 92/422 (21%), Positives = 182/422 (43%), Gaps = 46/422 (10%)
Query: 769 AMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEA 828
A++ K++ LEQ VELS ++ A ++ + +LR++ L + ++
Sbjct: 414 ALERKLQCLEQEKVELSRKHQEALHAP--------TDHRELEQLRKEVQTLRDRLPEMLR 465
Query: 829 QNRKLEEQLEKISHQDHSDKNRLLELETRLREVS-----LEHEEQKL-ELKRQLTELQLS 882
L + + D + EL+ RE++ L+ +EQ+L + Q EL
Sbjct: 466 DKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQR 525
Query: 883 LQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNS 942
LQE + + A + AL SQL +A+ E A+ + +T + + +++ + +
Sbjct: 526 LQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQA 585
Query: 943 CTVITDLEEQLNQLTE---DNAELNNQNFYLSKQLDEA-----SGANDEIVQLRSEVDHL 994
T+ T E E A+L + L +QL++A SG + + QL+ E L
Sbjct: 586 KTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRL 645
Query: 995 RREITEREMQLTSQKQTMEAL----KTTCTMLEEQVMD-LEALNDELLEKERQWEAWRSV 1049
RE E +L ++++ + L + T + E Q+ D L +NDE + + +A +
Sbjct: 646 SREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSR-GYLQALATK 704
Query: 1050 LGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKE 1109
+ +E + + Q +AR Q++ S + L LQ AL+
Sbjct: 705 MAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASAR-------------LELQSALEA 751
Query: 1110 QKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRL--LEEQAKLQQQMDLQK 1167
+ + L ++L +++ E R LQ+ + + L+Q L L E+ + + +D +
Sbjct: 752 EIRAKQGLQERLTQVQEAQLQAE---RRLQEAEKQSQALQQELAMLREELRARGPVDTKP 808
Query: 1168 NH 1169
++
Sbjct: 809 SN 810
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 404 bits (1037), Expect = e-112
Identities = 313/1054 (29%), Positives = 526/1054 (49%), Gaps = 154/1054 (14%)
Query: 47 SREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCG 106
S E +LD L L++EC+ L + K++ ++ +++++++ +DFE+ ++G G
Sbjct: 27 SVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRG 86
Query: 107 HFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQD 166
F EV VV+ K ++AMK++ K +L + + + F EER++L + WI L YAFQD
Sbjct: 87 AFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQD 146
Query: 167 KNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPEN 226
N+LYLVM+Y GGDLL+LL+++ED+L E++ +FYLAE+++A+ SVH + YVHRDIKP+N
Sbjct: 147 DNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDN 206
Query: 227 ILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDW 286
IL+D GHI+L DFGS K+ + V + + +GTPDY++PE+L M DGKG YG +CDW
Sbjct: 207 ILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME-DGKGRYGPECDW 265
Query: 287 WSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDD-PKVSSDFLDLIQSLLCGQ 345
WS+GV YEM+YG +PF + T+ IMN + +FP VS + DLI+ L+C +
Sbjct: 266 WSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSR 325
Query: 346 KERLKFEGL---CCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPE---KNSWVSS 399
+ RL G+ HPFFS IDW+NIRN P++P + S DTSNFD + KNS
Sbjct: 326 EHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMP 385
Query: 400 SPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQ 459
P + + FSG LPFVGF+Y+ + + RS V+ + ++ L + +
Sbjct: 386 PP---THTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATE 442
Query: 460 DSQDKCHKMEQEMTRLHRRVSE----VEA---------VLSQKEVELKASETQRSLLEQD 506
+ + ++EQE L R++ E V+A + + K++E+K + + L +
Sbjct: 443 AYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQ 502
Query: 507 LATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRL 566
+TE S L++ LE+A V QE D A + + +Q + LQ+ +E
Sbjct: 503 ----VTESSHLEQQLEEAN-AVRQELDDAFRQIKAYEKQIKTLQQERE------------ 545
Query: 567 MMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAK 626
L ++LV A R EL+++ CQ KL Q E+ E +
Sbjct: 546 ---DLNKELVQASERLKNQSKELKDA------------HCQRKLAM---QEFMEINE--R 585
Query: 627 LEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGI 686
L +++ ++Q + +++K E+ + L Q +R+ ERA++ELE +
Sbjct: 586 LTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRT-ERAKKELEVHTEALAAEASK 644
Query: 687 RKKLVEAEELEEKHREAQVSAQHLEVHLKQKE----------QHYEEKIKVLDNQIKKDL 736
+KL E E K E ++ LKQK+ +H +E K+ + KK +
Sbjct: 645 DRKLREQSEHYSKQLENELEG------LKQKQISYSPGVCSIEHQQEITKLKTDLEKKSI 698
Query: 737 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSL 796
+E L H E K L + + A++ +I L+ ++ +
Sbjct: 699 FYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEK------------- 745
Query: 797 FTQRNMKAQ-EEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELE 855
T+R +++ EE SE +QQ E + L +N+KL +L+K+
Sbjct: 746 -TRRESQSEREEFESEFKQQ---YEREKVLLTEENKKLTSELDKL--------------- 786
Query: 856 TRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 915
T L E H +Q E + L + + S+ E+Q+ TE+ +
Sbjct: 787 TTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQI------------------TEIIQWV 828
Query: 916 AEAEEEIQALTAHRDEIQRKFDALRNSC--TVITDLEEQLNQLTEDNAELNNQNFYLSKQ 973
++ ++ L A ++ + +ALRNS T TD+ ++ + A+L+ +S +
Sbjct: 829 SDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRF----AKLD-----MSAR 879
Query: 974 LDEASGANDEIVQLRSEVDHLRRE-----ITEREMQLTSQKQTMEALKTTCTMLEEQVMD 1028
L+ S + EI ++ + L + ITE +++ S+K+ +E L + +E+ + D
Sbjct: 880 LELQSALDAEIRAKQAIQEELNKVKASNIITECKLK-DSEKKNLELL----SEIEQLIKD 934
Query: 1029 LEALNDEL----LEKERQWEAWRSVLGDEKSQFE 1058
E L E + + + A+ + D QFE
Sbjct: 935 TEELRSEKGIEHQDSQHSFLAFLNTPTDALDQFE 968
Score = 178 bits (452), Expect = 4e-44
Identities = 239/1114 (21%), Positives = 448/1114 (40%), Gaps = 153/1114 (13%)
Query: 803 KAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVS 862
+A E I L Q+K L +RKL+E + + +S + L L +
Sbjct: 442 EAYERRIKRLEQEKLEL----------SRKLQESTQTVQALQYSTVDGPLTASKDLEIKN 491
Query: 863 LEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEI 922
L+ E +KL ++Q+TE E QL A R L+ RQ K E++I
Sbjct: 492 LKEEIEKL--RKQVTESS----HLEQQLEEANAVRQELDDAFRQIKAY--------EKQI 537
Query: 923 QALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND 982
+ L R+++ + +L + +L + EL + + + E N+
Sbjct: 538 KTLQQEREDLNK-------------ELVQASERLKNQSKELKDAHCQRKLAMQEFMEINE 584
Query: 983 EIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQ 1042
+ +L ++ L R + ++E ++ Q +E+L+ E +LE + L + +
Sbjct: 585 RLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASK 644
Query: 1043 WEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ---RITESRQVVELAVKEHKAE 1099
R Q E ++L+ L+ KQ + I +++ +L K
Sbjct: 645 DRKLRE-------QSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKS 697
Query: 1100 ILALQQALKEQKLKA---ESLSDKLNDLEKKHAMLEMNARSLQQKLE-TERELKQRLLEE 1155
I ++ K + + A ++L +L+D E + L L+ KLE T RE + E
Sbjct: 698 IFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEF 757
Query: 1156 QAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGT 1215
+++ +QQ + +K + + L LD+ L S QLE + +K +
Sbjct: 758 ESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHW 817
Query: 1216 ISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPAL--------PTQVPLQYN-----ELK 1262
+Q T++I ++ + D + +E AL T +P + ++
Sbjct: 818 EAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMS 877
Query: 1263 LALEKEKARCAELEEALQKTRIELRSAREE----AAHRKATDHPHPSTPATARQQIAMSA 1318
LE + A AE+ A Q + EL + K ++ + + Q I +
Sbjct: 878 ARLELQSALDAEIR-AKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTE 936
Query: 1319 IVRSP---EHQPSAMSLLA-----------------------PPSSRRKESSTPEEFSRR 1352
+RS EHQ S S LA P+ R+K F +
Sbjct: 937 ELRSEKGIEHQDSQHSFLAFLNTPTDALDQFETVDSTPLSVHTPTLRKKGCPGSTGFPPK 996
Query: 1353 LKERMHHNIPHRFNVGLNMRATKCAVCLDT-VHFGRQASKCLECQVMCHPKCSTCLPATC 1411
K H+F V TKC C V RQ C C CH C P TC
Sbjct: 997 RKT-------HQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTC 1049
Query: 1412 GLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLE 1471
+P E G+ ++ + + EG +++P+ ++GW R ++
Sbjct: 1050 PVPPEQTK-----------GPLGIDPQKGIGTAY-EGHVRIPKP-AGVKKGWQRALAIVC 1096
Query: 1472 GSKVLIYDNEAREAGQRPVEEFELC-LPDGDVSIHGAVGASELANTAKADVPYILKMESH 1530
K+ +YD +A Q V ++ + D + S+ +V AS++ + ++ D+P I ++ +
Sbjct: 1097 DFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSV-SSVLASDVIHASRKDIPCIFRVTAS 1155
Query: 1531 PHTTCWPGRTLYLLAPSFPDKQRWVTALESV--VAGGRVSREKAEADAKLLGNSLLKLEG 1588
+ ++ +LA + +K +WV L + + R+++ K +S L L
Sbjct: 1156 QLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIK 1215
Query: 1589 DDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIA 1648
+ + + +G EEGL+ ++V K+ + V + QI +I + + + +I+
Sbjct: 1216 TTQ----AAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVIS 1271
Query: 1649 GEERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIENGL--CICAAM 1706
G R + L + + + ++ KGC +GK+ +G C+C AM
Sbjct: 1272 GRNRHVRLFPMSALDGRETDFYKLSE----------TKGCQTVTSGKVRHGALTCLCVAM 1321
Query: 1707 PSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLE---- 1762
+V+ ++ +++ KEI+ + + + +G ++ +Y L
Sbjct: 1322 KRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVG----FQSGFLRYPLNGEGN 1377
Query: 1763 --EFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRT 1820
L NDH+L+ F A + V+++S +EYLLCF+ G++ D GRRSR
Sbjct: 1378 PYSMLHSNDHTLS---FIAHQPMDAICAVEISS----KEYLLCFNSIGIYTDCQGRRSRQ 1430
Query: 1821 DDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQA 1854
+L W P + Y PYL V N++++ ++ +
Sbjct: 1431 QELMWPANPSSCCYNAPYLSVYSENAVDIFDVNS 1464
>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
Length = 1638
Score = 392 bits (1006), Expect = e-108
Identities = 274/931 (29%), Positives = 464/931 (49%), Gaps = 90/931 (9%)
Query: 47 SREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCG 106
S E +LD L L++EC+ L + K++ ++ +++++++ +DFE+ ++G G
Sbjct: 27 SVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRG 86
Query: 107 HFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQD 166
F EV VV+ K ++AMK++ K +L + + + F EER++L + WI L YAFQD
Sbjct: 87 AFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQD 146
Query: 167 KNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPEN 226
N+LYLVM+Y GGDLL+LL+++ED+L E++ +FYLAE+++A+ SVH + YVHRDIKP+N
Sbjct: 147 DNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDN 206
Query: 227 ILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDW 286
IL+D GHI+L DFGS K+ + V + + +GTPDY++PE+L M DGKG YG +CDW
Sbjct: 207 ILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME-DGKGRYGPECDW 265
Query: 287 WSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDD-PKVSSDFLDLIQSLLCGQ 345
WS+GV YEM+YG +PF + T+ IMN + +FP VS + DLI+ L+C +
Sbjct: 266 WSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSR 325
Query: 346 KERLKFEGL---CCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPE---KNSWVSS 399
+ RL G+ HPFFS IDW+NIRN P++P + S DTSNFD + KNS
Sbjct: 326 EHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMP 385
Query: 400 SPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQ 459
P + + FSG LPFVGF+Y+ + + RS V+ + ++ L + +
Sbjct: 386 PP---THTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATE 442
Query: 460 DSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKR 519
+ + ++EQE L R++ E +Q L+ S L A+ E +LK
Sbjct: 443 AYERRIKRLEQEKLELSRKLQE----STQTVQALQYSTVDGPL----TASKDLEIKNLKE 494
Query: 520 SLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSAR 579
+E+ R +V++ L + E + QE+ + Q + E ++ Q E
Sbjct: 495 EIEKLRKQVTESS----HLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQE------- 543
Query: 580 RRSDLYESELRESRLAAEEFK----RKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQ 635
R DL + E+ LAAE K R+ +E K L+ + +G + + E Q
Sbjct: 544 -REDLNKLEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQ 602
Query: 636 LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEG-----IRKKL 690
+I +L+ LEK E + I E++ L+ SEG ++ +
Sbjct: 603 QEITKLKTDLEKKSIFYEEELSKREGIH------ANEIKNLKKELHDSEGQQLALNKEIM 656
Query: 691 VEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHE 750
+ ++LE+ RE+Q + E KQ+ + + + + ++ +L TL + H
Sbjct: 657 ILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHN 716
Query: 751 EEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMIS 810
++ E+ K L+++K + +++I + Q + + +A
Sbjct: 717 QQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDAR---------------------- 754
Query: 811 ELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKL 870
G L+A K+ E+LE + ++ S R ++ ++R + +L
Sbjct: 755 -------------GYLQALASKMTEELEAL--RNSSLGTRATDMPWKMRRFAKLDMSARL 799
Query: 871 ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK-------TELEETTAEAEEEIQ 923
EL+ L + Q + +L ++A+ E +L+ ++ +E+E+ + EE
Sbjct: 800 ELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRS 859
Query: 924 ALTAHRDEIQRKFDALRNSCTVITDLEEQLN 954
+ Q F A N+ T D E ++
Sbjct: 860 EKGIEHQDSQHSFLAFLNTPTDALDQFETVD 890
Score = 165 bits (418), Expect = 4e-40
Identities = 216/1029 (20%), Positives = 438/1029 (42%), Gaps = 137/1029 (13%)
Query: 866 EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEET------TAEAE 919
E++KLEL R+L E ++Q + T A+ + +++ K E+E+ ++ E
Sbjct: 452 EQEKLELSRKLQESTQTVQALQYS-TVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLE 510
Query: 920 EEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG 979
++++ A R E+ DA R I E+Q+ L ++ +LN + EAS
Sbjct: 511 QQLEEANAVRQELD---DAFRQ----IKAYEKQIKTLQQEREDLNKLEVHTEALAAEASK 563
Query: 980 ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVM-----DLEALN- 1033
+LR + +H +++ E E++ QKQ + C++ +Q + DLE +
Sbjct: 564 DR----KLREQSEHYSKQL-ENELEGLKQKQISYS-PGVCSIEHQQEITKLKTDLEKKSI 617
Query: 1034 ---DELLEKE----RQWEAWRSVLGDEKSQFECRVRELQRMLD----TEKQSRARADQRI 1082
+EL ++E + + + L D + Q +E+ + D T ++S++ ++
Sbjct: 618 FYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFE 677
Query: 1083 TESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL 1142
+E +Q +++ E + L + K+ + + L+ +L + LE + L K
Sbjct: 678 SEFKQ-------QYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADKK 730
Query: 1143 ETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALD--RADLLKTERSDLEYQLEN 1200
E+ + ++ E + + D + ++ L + E L+ R L T +D+ +++
Sbjct: 731 ESVAHWEAQITEIIQWVSDEKDA-RGYLQALASKMTEELEALRNSSLGTRATDMPWKMRR 789
Query: 1201 IQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNE 1260
L +++++ + + + +Q ++++ K + + K
Sbjct: 790 FAKLDMSARLELQSALDAEIRAKQAIQEELNKV--KASNIITECK--------------- 832
Query: 1261 LKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPS---TPATARQQIAMS 1317
LK + +K +E+E+ ++ T ELRS E+ + + H + TP A Q
Sbjct: 833 LKDSEKKNLELLSEIEQLIKDTE-ELRS--EKGIEHQDSQHSFLAFLNTPTDALDQF--- 886
Query: 1318 AIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCA 1377
E S + P+ R+K F + K H+F V TKC
Sbjct: 887 ------ETVDSTPLSVHTPTLRKKGCPGSTGFPPKRKT-------HQFFVKSFTTPTKCH 933
Query: 1378 VCLDT-VHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQ 1436
C V RQ C C CH C P TC +P E G+
Sbjct: 934 QCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTK-----------GPLGID 982
Query: 1437 TKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELC 1496
++ + + EG +++P+ ++GW R ++ K+ +YD +A Q V ++
Sbjct: 983 PQKGIGTAY-EGHVRIPKP-AGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVI 1040
Query: 1497 -LPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWV 1555
+ D + S+ +V AS++ + ++ D+P I ++ + + ++ +LA + +K +WV
Sbjct: 1041 DMRDEEFSV-SSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWV 1099
Query: 1556 TALESV--VAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGL 1613
L + + R+++ K +S L L + + + +G EEGL
Sbjct: 1100 GVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQ----AAAIIDHERIALGNEEGL 1155
Query: 1614 YALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPA 1673
+ ++V K+ + V + QI +I + + + +I+G R + L + + + +
Sbjct: 1156 FVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLS 1215
Query: 1674 QPDISPNIFEAVKGCHLFGAGKIENGL--CICAAMPSKVVILRYNENLSKYCIRKEIETS 1731
+ KGC +GK+ +G C+C AM +V+ ++ +++ KEI+
Sbjct: 1216 E----------TKGCQTVTSGKVRHGALTCLCVAMKRQVLCYELFQSKTRHRKFKEIQVP 1265
Query: 1732 EPCSCIHFTNYSILIGTNKFYEIDMKQYTLE------EFLDKNDHSLAPAVFAASSNSFP 1785
+ + + +G ++ +Y L L NDH+L+ F A
Sbjct: 1266 YNVQWMAIFSEQLCVG----FQSGFLRYPLNGEGNPYSMLHSNDHTLS---FIAHQPMDA 1318
Query: 1786 VSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFN 1845
+ V+++S +EYLLCF+ G++ D GRRSR +L W P + Y PYL V N
Sbjct: 1319 ICAVEISS----KEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSEN 1374
Query: 1846 SLEVIEIQA 1854
++++ ++ +
Sbjct: 1375 AVDIFDVNS 1383
Score = 68.6 bits (166), Expect = 6e-11
Identities = 108/476 (22%), Positives = 212/476 (44%), Gaps = 83/476 (17%)
Query: 633 EQQLKIQELQEKLE--KAVKASTEATELLQ-NIRQAKERAERELEKLQNREDSSEGIRKK 689
E+++K E QEKLE + ++ ST+ + LQ + A ++LE ++N ++ E +RK+
Sbjct: 445 ERRIKRLE-QEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLE-IKNLKEEIEKLRKQ 502
Query: 690 LVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRH 749
+ E+ LE++ EA Q L+ +Q + YE++IK L + ++DL N ++ H
Sbjct: 503 VTESSHLEQQLEEANAVRQELDDAFRQIKA-YEKQIKTLQQE-REDL-------NKLEVH 553
Query: 750 EE----EAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQ 805
E EA + K+ + + +++++ L+Q+ + S + + + +
Sbjct: 554 TEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPG--------VCSIEHQQEI 605
Query: 806 EEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLE--------LETR 857
++ ++L ++ + E + K E + + L+K H + L + LE
Sbjct: 606 TKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKT 665
Query: 858 LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT-- 915
RE E EE + E K+Q ++ L E +LT+ L L +LEE
Sbjct: 666 RRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKD 725
Query: 916 ------------AEAEEEIQALTAHRD----------EIQRKFDALRNSC--TVITDLEE 951
A+ E IQ ++ +D ++ + +ALRNS T TD+
Sbjct: 726 LADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPW 785
Query: 952 QLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRRE-----ITEREMQLT 1006
++ + A+L+ +S +L+ S + EI ++ + L + ITE +++
Sbjct: 786 KMRRF----AKLD-----MSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLK-D 835
Query: 1007 SQKQTMEALKTTCTMLEEQVMDLEALNDEL----LEKERQWEAWRSVLGDEKSQFE 1058
S+K+ +E L + +E+ + D E L E + + + A+ + D QFE
Sbjct: 836 SEKKNLELL----SEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTPTDALDQFE 887
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 335 bits (858), Expect = 3e-91
Identities = 193/513 (37%), Positives = 294/513 (57%), Gaps = 33/513 (6%)
Query: 46 LSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGC 105
L E +LD L + +E L + K+V++F++ + L+E++ DFE+ ++G
Sbjct: 20 LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGR 79
Query: 106 GHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQ 165
G F+EV VV+ K TG +YAMK+M K +L + +VS F EER++L WI QL +AFQ
Sbjct: 80 GAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQ 139
Query: 166 DKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPE 225
D+N+LYLVMEY GGDLL+LL+++ +++ + +FYLAE+++A+ SVH +GYVHRDIKP+
Sbjct: 140 DENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPD 199
Query: 226 NILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVL-TVMNGDGKGTYGLDC 284
NIL+DR GHI+L DFGS K+ ++ V + + +GTPDY++PE+L V G G G+YG +C
Sbjct: 200 NILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPEC 259
Query: 285 DWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFP-DDPKVSSDFLDLIQSLLC 343
DWW++GV AYEM YG++PF ++A T+ I++++ L P D V + D IQ LLC
Sbjct: 260 DWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLC 319
Query: 344 GQKERLKFEG---LCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSS 400
+ RL G HPFF +DW+ +R+S PPF P + DT NFD E +
Sbjct: 320 PPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMET 379
Query: 401 PCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLL---IKSKE 457
+ G LPFVG+SYS + +S V G P ++LL +++
Sbjct: 380 LSDIREGAPLGVHLPFVGYSYS----CMALRDSEVPG---PTPMELEAEQLLEPHVQAPS 432
Query: 458 LQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASE---TQRSLL---------EQ 505
L+ S + + +E EA ++ +E++ E T++SL Q
Sbjct: 433 LEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQ 492
Query: 506 DLATYITECSSLKRSLE------QARMEVSQED 532
+ A+ + E + R LE Q RME+ Q +
Sbjct: 493 NFASQLREAEARNRDLEAHVRQLQERMELLQAE 525
Score = 32.7 bits (73), Expect = 3.7
Identities = 23/80 (28%), Positives = 37/80 (46%), Gaps = 3/80 (3%)
Query: 853 ELETRLREVSLEHEEQKL---ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKT 909
E E LRE+ EE+ L L R++ ++ Q SQL +A LE+ +RQ +
Sbjct: 458 EAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQE 517
Query: 910 ELEETTAEAEEEIQALTAHR 929
+E AE + + + R
Sbjct: 518 RMELLQAEGATAVTGVPSPR 537
Score = 31.6 bits (70), Expect = 8.2
Identities = 23/82 (28%), Positives = 38/82 (46%), Gaps = 5/82 (6%)
Query: 643 EKLEKAVKASTEATELLQNI--RQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKH 700
E E AV A+ A E + R+ +E E E+ Q+ E IR + + +
Sbjct: 442 ETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIR---TDNQNFASQL 498
Query: 701 REAQVSAQHLEVHLKQKEQHYE 722
REA+ + LE H++Q ++ E
Sbjct: 499 REAEARNRDLEAHVRQLQERME 520
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 335 bits (858), Expect = 3e-91
Identities = 193/513 (37%), Positives = 294/513 (57%), Gaps = 33/513 (6%)
Query: 46 LSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGC 105
L E +LD L + +E L + K+V++F++ + L+E++ DFE+ ++G
Sbjct: 20 LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGR 79
Query: 106 GHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQ 165
G F+EV VV+ K TG +YAMK+M K +L + +VS F EER++L WI QL +AFQ
Sbjct: 80 GAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQ 139
Query: 166 DKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPE 225
D+N+LYLVMEY GGDLL+LL+++ +++ + +FYLAE+++A+ SVH +GYVHRDIKP+
Sbjct: 140 DENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPD 199
Query: 226 NILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVL-TVMNGDGKGTYGLDC 284
NIL+DR GHI+L DFGS K+ ++ V + + +GTPDY++PE+L V G G G+YG +C
Sbjct: 200 NILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPEC 259
Query: 285 DWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFP-DDPKVSSDFLDLIQSLLC 343
DWW++GV AYEM YG++PF ++A T+ I++++ L P D V + D IQ LLC
Sbjct: 260 DWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLC 319
Query: 344 GQKERLKFEG---LCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSS 400
+ RL G HPFF +DW+ +R+S PPF P + DT NFD E +
Sbjct: 320 PPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMET 379
Query: 401 PCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLL---IKSKE 457
+ G LPFVG+SYS + +S V G P ++LL +++
Sbjct: 380 LSDIREGAPLGVHLPFVGYSYS----CMALRDSEVPG---PTPMELEAEQLLEPHVQAPS 432
Query: 458 LQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASE---TQRSLL---------EQ 505
L+ S + + +E EA ++ +E++ E T++SL Q
Sbjct: 433 LEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQ 492
Query: 506 DLATYITECSSLKRSLE------QARMEVSQED 532
+ A+ + E + R LE Q RME+ Q +
Sbjct: 493 NFASQLREAEARNRDLEAHVRQLQERMELLQAE 525
Score = 32.7 bits (73), Expect = 3.7
Identities = 23/80 (28%), Positives = 37/80 (46%), Gaps = 3/80 (3%)
Query: 853 ELETRLREVSLEHEEQKL---ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKT 909
E E LRE+ EE+ L L R++ ++ Q SQL +A LE+ +RQ +
Sbjct: 458 EAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQE 517
Query: 910 ELEETTAEAEEEIQALTAHR 929
+E AE + + + R
Sbjct: 518 RMELLQAEGATAVTGVPSPR 537
Score = 31.6 bits (70), Expect = 8.2
Identities = 23/82 (28%), Positives = 38/82 (46%), Gaps = 5/82 (6%)
Query: 643 EKLEKAVKASTEATELLQNI--RQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKH 700
E E AV A+ A E + R+ +E E E+ Q+ E IR + + +
Sbjct: 442 ETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIR---TDNQNFASQL 498
Query: 701 REAQVSAQHLEVHLKQKEQHYE 722
REA+ + LE H++Q ++ E
Sbjct: 499 REAEARNRDLEAHVRQLQERME 520
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 331 bits (848), Expect = 5e-90
Identities = 197/518 (38%), Positives = 297/518 (57%), Gaps = 38/518 (7%)
Query: 46 LSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGC 105
L E +LD L + +E L + K+V++F++ + L+E++ DFE+ ++G
Sbjct: 20 LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGR 79
Query: 106 GHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQ 165
G F+EV VV+ K TG +YAMK+M K +L + +VS F EER++L WI QL +AFQ
Sbjct: 80 GAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQ 139
Query: 166 DKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPE 225
D+N+LYLVMEY GGDLL+LL+++ +++ + +FYLAE+++A+ SVH +GYVHRDIKP+
Sbjct: 140 DENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPD 199
Query: 226 NILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVL-TVMNGDGKGTYGLDC 284
NIL+DR GHI+L DFGS K+ ++ V + + +GTPDY++PE+L V G G G+YG +C
Sbjct: 200 NILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPEC 259
Query: 285 DWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFP-DDPKVSSDFLDLIQSLLC 343
DWW++GV AYEM YG++PF ++A T+ I++++ L P D V + D IQ LLC
Sbjct: 260 DWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLC 319
Query: 344 GQKERLKFEG---LCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFD--EPEKNSWVS 398
+ RL G HPFF +DW+ +R+S PPF P + DT NFD E + VS
Sbjct: 320 PPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVS 379
Query: 399 SSPCQLS---PSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLL--- 452
LS G LPFVG+SYS + +S V G P ++LL
Sbjct: 380 GGGETLSDIREGAPLGVHLPFVGYSYS----CMALRDSEVPG---PTPMELEAEQLLEPH 432
Query: 453 IKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASE---TQRSLL------ 503
+++ L+ S + + +E EA ++ +E++ E T++SL
Sbjct: 433 VQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAI 492
Query: 504 ---EQDLATYITECSSLKRSLE------QARMEVSQED 532
Q+ A+ + E + R LE Q RME+ Q +
Sbjct: 493 RTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAE 530
Score = 32.7 bits (73), Expect = 3.7
Identities = 23/80 (28%), Positives = 37/80 (46%), Gaps = 3/80 (3%)
Query: 853 ELETRLREVSLEHEEQKL---ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKT 909
E E LRE+ EE+ L L R++ ++ Q SQL +A LE+ +RQ +
Sbjct: 463 EAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQE 522
Query: 910 ELEETTAEAEEEIQALTAHR 929
+E AE + + + R
Sbjct: 523 RMELLQAEGATAVTGVPSPR 542
Score = 31.6 bits (70), Expect = 8.2
Identities = 23/82 (28%), Positives = 38/82 (46%), Gaps = 5/82 (6%)
Query: 643 EKLEKAVKASTEATELLQNI--RQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKH 700
E E AV A+ A E + R+ +E E E+ Q+ E IR + + +
Sbjct: 447 ETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIR---TDNQNFASQL 503
Query: 701 REAQVSAQHLEVHLKQKEQHYE 722
REA+ + LE H++Q ++ E
Sbjct: 504 REAEARNRDLEAHVRQLQERME 525
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 317 bits (813), Expect = 6e-86
Identities = 187/480 (38%), Positives = 278/480 (57%), Gaps = 38/480 (7%)
Query: 84 IAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFE 143
+ L+E++ DFE+ ++G G F+EV VV+ K TG +YAMK+M K +L + +VS F
Sbjct: 68 VVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFR 127
Query: 144 EERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLA 203
EER++L WI QL +AFQD+N+LYLVMEY GGDLL+LL+++ +++ + +FYLA
Sbjct: 128 EERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLA 187
Query: 204 ELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDY 263
E+++A+ SVH +GYVHRDIKP+NIL+DR GHI+L DFGS K+ ++ V + + +GTPDY
Sbjct: 188 EIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDY 247
Query: 264 MAPEVL-TVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFL 322
++PE+L V G G G+YG +CDWW++GV AYEM YG++PF ++A T+ I++++ L
Sbjct: 248 LSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHL 307
Query: 323 KFP-DDPKVSSDFLDLIQSLLCGQKERLKFEG---LCCHPFFSKIDWNNIRNSPPPFVPT 378
P D V + D IQ LLC + RL G HPFF +DW+ +R+S PPF P
Sbjct: 308 SLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPD 367
Query: 379 LKSDDDTSNFD--EPEKNSWVSSSPCQLS---PSGFSGEELPFVGFSYSKALGILGRSES 433
+ DT NFD E + VS LS G LPFVG+SYS + +S
Sbjct: 368 FEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYS----CMALRDS 423
Query: 434 VVSGLDSPAKTSSMEKKLL---IKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKE 490
V G P ++LL +++ L+ S + + +E EA ++ +E
Sbjct: 424 EVPG---PTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRE 480
Query: 491 VELKASE---TQRSLL---------EQDLATYITECSSLKRSLE------QARMEVSQED 532
++ E T++SL Q+ A+ + E + R LE Q RME+ Q +
Sbjct: 481 LQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAE 540
Score = 32.7 bits (73), Expect = 3.7
Identities = 23/80 (28%), Positives = 37/80 (46%), Gaps = 3/80 (3%)
Query: 853 ELETRLREVSLEHEEQKL---ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKT 909
E E LRE+ EE+ L L R++ ++ Q SQL +A LE+ +RQ +
Sbjct: 473 EAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQE 532
Query: 910 ELEETTAEAEEEIQALTAHR 929
+E AE + + + R
Sbjct: 533 RMELLQAEGATAVTGVPSPR 552
Score = 31.6 bits (70), Expect = 8.2
Identities = 23/82 (28%), Positives = 38/82 (46%), Gaps = 5/82 (6%)
Query: 643 EKLEKAVKASTEATELLQNI--RQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKH 700
E E AV A+ A E + R+ +E E E+ Q+ E IR + + +
Sbjct: 457 ETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIR---TDNQNFASQL 513
Query: 701 REAQVSAQHLEVHLKQKEQHYE 722
REA+ + LE H++Q ++ E
Sbjct: 514 REAEARNRDLEAHVRQLQERME 535
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 192 bits (488), Expect = 3e-48
Identities = 119/327 (36%), Positives = 177/327 (54%), Gaps = 23/327 (7%)
Query: 96 DFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSP 155
DF+ L+G G F +V +VREKA+G YAMK++KK+ ++A+++V+ E +L + P
Sbjct: 147 DFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHP 206
Query: 156 WIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLM 215
++ L+Y+FQ K+ L VMEY GG+L L+R E E+ +FY AE++ A+ +H
Sbjct: 207 FLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSR-ERVFSEDRTRFYGAEIVSALDYLHSG 265
Query: 216 GYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGD 275
V+RD+K EN+++D+ GHIK+ DFG K K GTP+Y+APEVL
Sbjct: 266 KIVYRDLKLENLMLDKDGHIKITDFG-LCKEGITDAATMKTFCGTPEYLAPEVLE----- 319
Query: 276 GKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFL 335
YG DWW +GV+ YEM+ GR PF + F I+ +KFP +SSD
Sbjct: 320 -DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEDIKFP--RTLSSDAK 374
Query: 336 DLIQSLLCGQKERLKFEG------LCCHPFFSKIDWNNI--RNSPPPFVPTLKSDDDTSN 387
L+ LL + G + H FFS ++W ++ + PPF P + S+ DT
Sbjct: 375 SLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRY 434
Query: 388 FDEPEKNSWVSSSP---CQLSPSGFSG 411
FDE ++ +P CQ S G G
Sbjct: 435 FDEEFTAQTITITPPEKCQQSDCGMLG 461
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 188 bits (478), Expect = 4e-47
Identities = 114/314 (36%), Positives = 172/314 (54%), Gaps = 20/314 (6%)
Query: 96 DFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSP 155
DF+ L+G G F +V +VREKA+G YAMK++KK+ ++A+++V+ E +L + P
Sbjct: 147 DFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHP 206
Query: 156 WIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLM 215
++ L+Y+FQ K+ L VMEY GG+L L+R E E+ +FY AE++ A+ +H
Sbjct: 207 FLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSR-ERVFSEDRTRFYGAEIVSALDYLHSG 265
Query: 216 GYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGD 275
V+RD+K EN+++D+ GHIK+ DFG K K GTP+Y+APEVL
Sbjct: 266 KIVYRDLKLENLMLDKDGHIKITDFG-LCKEGITDAATMKTFCGTPEYLAPEVLE----- 319
Query: 276 GKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFL 335
YG DWW +GV+ YEM+ GR PF + F I+ +KFP +SSD
Sbjct: 320 -DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEDIKFP--RTLSSDAK 374
Query: 336 DLIQSLLCGQKERLKFEG------LCCHPFFSKIDWNNI--RNSPPPFVPTLKSDDDTSN 387
L+ LL + G + H FFS ++W ++ + PPF P + S+ DT
Sbjct: 375 SLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRY 434
Query: 388 FDEPEKNSWVSSSP 401
FDE ++ +P
Sbjct: 435 FDEEFTAQTITITP 448
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 188 bits (478), Expect = 4e-47
Identities = 125/348 (35%), Positives = 182/348 (52%), Gaps = 31/348 (8%)
Query: 92 PSAK--DFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNIL 149
P AK DF ++G G F +V + R KA YA+KV++KKA+L +++ ERN+L
Sbjct: 91 PHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVL 150
Query: 150 SRSTS-PWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILA 208
++ P++ L ++FQ + LY V++Y GG+L L R L+ +FY AE+ A
Sbjct: 151 LKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRA-RFYAAEIASA 209
Query: 209 VHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEV 268
+ +H + V+RD+KPENIL+D GHI L DFG K N GTP+Y+APEV
Sbjct: 210 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG-LCKENIEHNSTTSTFCGTPEYLAPEV 268
Query: 269 LTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDP 328
L K Y DWW +G + YEM+YG PF +A ++NI+N LK P
Sbjct: 269 L------HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK----P 318
Query: 329 KVSSDFLDLIQSLLCGQKERLK-------FEGLCCHPFFSKIDWNNIRNS--PPPFVPTL 379
+++ L++ LL QK+R K F + H FFS I+W+++ N PPF P +
Sbjct: 319 NITNSARHLLEGLL--QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNV 376
Query: 380 KSDDDTSNFD-----EPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYS 422
+D +FD EP NS S L + F+GFSY+
Sbjct: 377 SGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYA 424
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 188 bits (478), Expect = 4e-47
Identities = 125/348 (35%), Positives = 182/348 (52%), Gaps = 31/348 (8%)
Query: 92 PSAK--DFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNIL 149
P AK DF ++G G F +V + R KA YA+KV++KKA+L +++ ERN+L
Sbjct: 105 PHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVL 164
Query: 150 SRSTS-PWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILA 208
++ P++ L ++FQ + LY V++Y GG+L L R L+ +FY AE+ A
Sbjct: 165 LKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRA-RFYAAEIASA 223
Query: 209 VHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEV 268
+ +H + V+RD+KPENIL+D GHI L DFG K N GTP+Y+APEV
Sbjct: 224 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG-LCKENIEHNSTTSTFCGTPEYLAPEV 282
Query: 269 LTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDP 328
L K Y DWW +G + YEM+YG PF +A ++NI+N LK P
Sbjct: 283 L------HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK----P 332
Query: 329 KVSSDFLDLIQSLLCGQKERLK-------FEGLCCHPFFSKIDWNNIRNS--PPPFVPTL 379
+++ L++ LL QK+R K F + H FFS I+W+++ N PPF P +
Sbjct: 333 NITNSARHLLEGLL--QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNV 390
Query: 380 KSDDDTSNFD-----EPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYS 422
+D +FD EP NS S L + F+GFSY+
Sbjct: 391 SGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYA 438
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 188 bits (478), Expect = 4e-47
Identities = 125/348 (35%), Positives = 182/348 (52%), Gaps = 31/348 (8%)
Query: 92 PSAK--DFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNIL 149
P AK DF ++G G F +V + R KA YA+KV++KKA+L +++ ERN+L
Sbjct: 119 PHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVL 178
Query: 150 SRSTS-PWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILA 208
++ P++ L ++FQ + LY V++Y GG+L L R L+ +FY AE+ A
Sbjct: 179 LKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRA-RFYAAEIASA 237
Query: 209 VHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEV 268
+ +H + V+RD+KPENIL+D GHI L DFG K N GTP+Y+APEV
Sbjct: 238 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG-LCKENIEHNSTTSTFCGTPEYLAPEV 296
Query: 269 LTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDP 328
L K Y DWW +G + YEM+YG PF +A ++NI+N LK P
Sbjct: 297 L------HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK----P 346
Query: 329 KVSSDFLDLIQSLLCGQKERLK-------FEGLCCHPFFSKIDWNNIRNS--PPPFVPTL 379
+++ L++ LL QK+R K F + H FFS I+W+++ N PPF P +
Sbjct: 347 NITNSARHLLEGLL--QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNV 404
Query: 380 KSDDDTSNFD-----EPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYS 422
+D +FD EP NS S L + F+GFSY+
Sbjct: 405 SGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYA 452
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 188 bits (478), Expect = 4e-47
Identities = 125/348 (35%), Positives = 182/348 (52%), Gaps = 31/348 (8%)
Query: 92 PSAK--DFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNIL 149
P AK DF ++G G F +V + R KA YA+KV++KKA+L +++ ERN+L
Sbjct: 186 PHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVL 245
Query: 150 SRSTS-PWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILA 208
++ P++ L ++FQ + LY V++Y GG+L L R L+ +FY AE+ A
Sbjct: 246 LKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRA-RFYAAEIASA 304
Query: 209 VHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEV 268
+ +H + V+RD+KPENIL+D GHI L DFG K N GTP+Y+APEV
Sbjct: 305 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG-LCKENIEHNSTTSTFCGTPEYLAPEV 363
Query: 269 LTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDP 328
L K Y DWW +G + YEM+YG PF +A ++NI+N LK P
Sbjct: 364 L------HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK----P 413
Query: 329 KVSSDFLDLIQSLLCGQKERLK-------FEGLCCHPFFSKIDWNNIRNS--PPPFVPTL 379
+++ L++ LL QK+R K F + H FFS I+W+++ N PPF P +
Sbjct: 414 NITNSARHLLEGLL--QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNV 471
Query: 380 KSDDDTSNFD-----EPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYS 422
+D +FD EP NS S L + F+GFSY+
Sbjct: 472 SGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYA 519
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 186 bits (471), Expect = 3e-46
Identities = 115/346 (33%), Positives = 188/346 (54%), Gaps = 33/346 (9%)
Query: 58 LFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREK 117
L++ + L K K +F++K+ + L+ DFE + +G G F V +V+ K
Sbjct: 58 LWDRSMKEFLAKAKE--DFLKKWENPTQNNAGLE----DFERKKTLGTGSFGRVMLVKHK 111
Query: 118 ATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQ 177
AT YAMK++ K+ ++ +Q+ E+ IL P++ +L+YAF+D ++LY+VMEY
Sbjct: 112 ATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYV 171
Query: 178 PGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKL 237
PGG++ S L R + E +FY A+++L +H + ++RD+KPEN+L+D G+I++
Sbjct: 172 PGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQV 230
Query: 238 VDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMI 297
DFG A ++ GTP+Y+APE++ KG Y DWW++GV+ YEM
Sbjct: 231 TDFGFAKRVKGRTWTLC----GTPEYLAPEIIL-----SKG-YNKAVDWWALGVLIYEMA 280
Query: 298 YGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEG---- 353
G PF + + I++ + ++FP SSD DL+++LL Q + K G
Sbjct: 281 AGYPPFFADQPIQIYEKIVSGK--VRFPS--HFSSDLKDLLRNLL--QVDLTKRFGNLKN 334
Query: 354 ----LCCHPFFSKIDWNNI--RNSPPPFVPTLKSDDDTSNFDEPEK 393
+ H +F+ DW I R PF+P + DTSNFD+ E+
Sbjct: 335 GVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEE 380
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 185 bits (470), Expect = 3e-46
Identities = 108/309 (34%), Positives = 173/309 (55%), Gaps = 27/309 (8%)
Query: 95 KDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTS 154
+DFE + +G G F V +V+ KAT YAMK++ K+ ++ +Q+ E+ IL
Sbjct: 42 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101
Query: 155 PWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHL 214
P++ +L+YAF+D ++LY+VMEY PGG++ S L R + E +FY A+++L +H
Sbjct: 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHS 160
Query: 215 MGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNG 274
+ ++RD+KPEN+L+D G+I++ DFG A ++ GTP+Y+APE++
Sbjct: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLC----GTPEYLAPEIIL---- 212
Query: 275 DGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDF 334
KG Y DWW++GV+ YEM G PF + + I++ + ++FP SSD
Sbjct: 213 -SKG-YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK--VRFPS--HFSSDL 266
Query: 335 LDLIQSLLCGQKERLKFEG--------LCCHPFFSKIDWNNI--RNSPPPFVPTLKSDDD 384
DL+++LL Q + K G + H +F+ DW I R PF+P + D
Sbjct: 267 KDLLRNLL--QVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGD 324
Query: 385 TSNFDEPEK 393
TSNFD+ E+
Sbjct: 325 TSNFDDYEE 333
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 184 bits (467), Expect = 8e-46
Identities = 111/302 (36%), Positives = 165/302 (54%), Gaps = 18/302 (5%)
Query: 96 DFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTS- 154
+FE ++G G F +V + R K TGD+YA+KV+KK +L + V E+ ILS + +
Sbjct: 354 NFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNH 413
Query: 155 PWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHL 214
P++ QL FQ + L+ VME+ GGDL+ + + + DE +FY AE+I A+ +H
Sbjct: 414 PFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSR-RFDEARARFYAAEIISALMFLHD 472
Query: 215 MGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNG 274
G ++RD+K +N+L+D GH KL DFG + N + A GTPDY+APE+L M
Sbjct: 473 KGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATF-CGTPDYIAPEILQEM-- 529
Query: 275 DGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFP-----DDPK 329
YG DWW++GV+ YEM+ G +PF F I+N + + +P D
Sbjct: 530 ----LYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDE--VVYPTWLHEDATG 583
Query: 330 VSSDFLDLIQSLLCGQKERLKFEGLCCHPFFSKIDWN--NIRNSPPPFVPTLKSDDDTSN 387
+ F+ ++ G + + HPFF +IDW N R PPF P +KS +D SN
Sbjct: 584 ILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSN 643
Query: 388 FD 389
FD
Sbjct: 644 FD 645
Score = 35.0 bits (79), Expect = 0.75
Identities = 16/63 (25%), Positives = 29/63 (46%), Gaps = 2/63 (3%)
Query: 1351 RRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVH--FGRQASKCLECQVMCHPKCSTCLP 1408
R ++ R+H H+F + T C+ C + + FG+Q +C C + H +C +
Sbjct: 160 RAMRRRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIV 219
Query: 1409 ATC 1411
C
Sbjct: 220 TAC 222
Score = 33.9 bits (76), Expect = 1.7
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 3/68 (4%)
Query: 1350 SRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFG--RQASKCLECQVMCHPKCSTCL 1407
S+ ++R NIPH+F++ T C C ++ +G RQ +C C++ H +C +
Sbjct: 233 SKIAEQRFGINIPHKFSIHNYKVPTFCDHC-GSLLWGIMRQGLQCKICKMNVHIRCQANV 291
Query: 1408 PATCGLPA 1415
CG+ A
Sbjct: 292 APNCGVNA 299
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 181 bits (458), Expect = 8e-45
Identities = 109/311 (35%), Positives = 172/311 (55%), Gaps = 27/311 (8%)
Query: 93 SAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRS 152
S+ FE +G G F V +VR + TG YAMK++ K+ ++ +QV E+ IL
Sbjct: 40 SSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAI 99
Query: 153 TSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSV 212
P++ +LQ++F+D ++LYLVMEY PGG++ S L R + E FY A+++LAV +
Sbjct: 100 DFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRV-GRFSEPHACFYAAQVVLAVQYL 158
Query: 213 HLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVM 272
H + +HRD+KPEN+L+D+ G++++ DFG A ++ GTP+Y+APE++
Sbjct: 159 HSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLC----GTPEYLAPEIIL-- 212
Query: 273 NGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSS 332
KG Y DWW++GV+ YEM G PF + + I++ + ++FP K+SS
Sbjct: 213 ---SKG-YNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGR--VRFPS--KLSS 264
Query: 333 DFLDLIQSLLCGQKERLKFEG--------LCCHPFFSKIDWNNI--RNSPPPFVPTLKSD 382
D L++SLL Q + K G + H +F+ W I + PF+P
Sbjct: 265 DLKHLLRSLL--QVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGP 322
Query: 383 DDTSNFDEPEK 393
D SNFD+ E+
Sbjct: 323 GDASNFDDYEE 333
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 180 bits (457), Expect = 1e-44
Identities = 113/303 (37%), Positives = 168/303 (55%), Gaps = 20/303 (6%)
Query: 96 DFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSP 155
DF+ L+G G F +V +VREKATG YAMK+++K+ ++A+++V+ E +L + P
Sbjct: 151 DFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHP 210
Query: 156 WIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLM 215
++ L+YAFQ + L VMEY GG+L L+R E E +FY AE++ A+ +H
Sbjct: 211 FLTALKYAFQTHDRLCFVMEYANGGELFFHLSR-ERVFTEERARFYGAEIVSALEYLHSR 269
Query: 216 GYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGD 275
V+RDIK EN+++D+ GHIK+ DFG K + K GTP+Y+APEVL
Sbjct: 270 DVVYRDIKLENLMLDKDGHIKITDFG-LCKEGISDGATMKTFCGTPEYLAPEVLE----- 323
Query: 276 GKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFL 335
YG DWW +GV+ YEM+ GR PF R F I+ ++FP +S +
Sbjct: 324 -DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL--MEEIRFP--RTLSPEAK 378
Query: 336 DLIQSLL-CGQKERL-----KFEGLCCHPFFSKIDWNNI--RNSPPPFVPTLKSDDDTSN 387
L+ LL K+RL + + H FF I+W ++ + PPF P + S+ DT
Sbjct: 379 SLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRY 438
Query: 388 FDE 390
FD+
Sbjct: 439 FDD 441
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 180 bits (457), Expect = 1e-44
Identities = 110/321 (34%), Positives = 167/321 (52%), Gaps = 31/321 (9%)
Query: 93 SAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRS 152
S +DF+ + VG G F V +V+EK +A+KVM ++ +Q E+++L
Sbjct: 45 SLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEV 104
Query: 153 TSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSV 212
+ P++ +L + + D+ LY++MEY PGG+L S L R + FY AE+I A+ +
Sbjct: 105 SHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYL-RNRGRFSSTTGLFYSAEIICAIEYL 163
Query: 213 HLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVM 272
H V+RD+KPENIL+DR GHIKL DFG A K+ GTP+Y+APEV+
Sbjct: 164 HSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLC----GTPEYLAPEVI--- 216
Query: 273 NGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIM----NFQRFLKFPDDP 328
KG +G DWW++G++ +EM+ G PF + + I+ +F R L F
Sbjct: 217 --QSKG-HGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDF---- 269
Query: 329 KVSSDFLDLIQSLLCGQKERL------KFEGLCCHPFFSKIDWNNI--RNSPPPFVPTLK 380
DLI+ LL + R + H +F +DW + R PP VP +
Sbjct: 270 ----HVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIA 325
Query: 381 SDDDTSNFDEPEKNSWVSSSP 401
D DTSNF+ +N W +++P
Sbjct: 326 GDGDTSNFETYPENDWDTAAP 346
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 180 bits (456), Expect = 1e-44
Identities = 110/333 (33%), Positives = 180/333 (54%), Gaps = 31/333 (9%)
Query: 71 KHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKK 130
K +F++K+ L FE +G G F V +V+ K TG+ YAMK++ K
Sbjct: 14 KAKEDFLKKWESPAQNTAHLD----QFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDK 69
Query: 131 KALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYE 190
+ ++ +Q+ E+ IL P++ +L+++F+D ++LY+VMEY PGG++ S L R
Sbjct: 70 QKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRI- 128
Query: 191 DQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNK 250
+ E +FY A+++L +H + ++RD+KPEN+L+D+ G+I++ DFG A ++
Sbjct: 129 GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT 188
Query: 251 MVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSAR 310
GTP+Y+APE++ KG Y DWW++GV+ YEM G PF +
Sbjct: 189 WTLC----GTPEYLAPEIIL-----SKG-YNKAVDWWALGVLIYEMAAGYPPFFADQPIQ 238
Query: 311 TFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEG--------LCCHPFFSK 362
+ I++ + ++FP SSD DL+++LL Q + K G + H +F+
Sbjct: 239 IYEKIVSGK--VRFPS--HFSSDLKDLLRNLL--QVDLTKRFGNLKNGVNDIKNHKWFAT 292
Query: 363 IDWNNI--RNSPPPFVPTLKSDDDTSNFDEPEK 393
DW I R PF+P K DTSNFD+ E+
Sbjct: 293 TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 325
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 180 bits (456), Expect = 1e-44
Identities = 110/333 (33%), Positives = 180/333 (54%), Gaps = 31/333 (9%)
Query: 71 KHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKK 130
K +F++K+ L FE +G G F V +V+ K TG+ YAMK++ K
Sbjct: 22 KAKEDFLKKWESPAQNTAHLD----QFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDK 77
Query: 131 KALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYE 190
+ ++ +Q+ E+ IL P++ +L+++F+D ++LY+VMEY PGG++ S L R
Sbjct: 78 QKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRI- 136
Query: 191 DQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNK 250
+ E +FY A+++L +H + ++RD+KPEN+L+D+ G+I++ DFG A ++
Sbjct: 137 GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT 196
Query: 251 MVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSAR 310
GTP+Y+APE++ KG Y DWW++GV+ YEM G PF +
Sbjct: 197 WTLC----GTPEYLAPEIIL-----SKG-YNKAVDWWALGVLIYEMAAGYPPFFADQPIQ 246
Query: 311 TFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEG--------LCCHPFFSK 362
+ I++ + ++FP SSD DL+++LL Q + K G + H +F+
Sbjct: 247 IYEKIVSGK--VRFPS--HFSSDLKDLLRNLL--QVDLTKRFGNLKNGVNDIKNHKWFAT 300
Query: 363 IDWNNI--RNSPPPFVPTLKSDDDTSNFDEPEK 393
DW I R PF+P K DTSNFD+ E+
Sbjct: 301 TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 333
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 178 bits (451), Expect = 5e-44
Identities = 154/558 (27%), Positives = 240/558 (43%), Gaps = 69/558 (12%)
Query: 91 QPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILS 150
+P DFE L+ G + V VR K + +AMK + K+ L+ + Q+ ER+IL+
Sbjct: 375 KPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILT 434
Query: 151 RSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVH 210
+ +P++ + +F+ + HL +VMEY GGD +L+ L ++ + Y AE +LA+
Sbjct: 435 FAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNM-GPLPVDMARMYFAETVLALE 493
Query: 211 SVHLMGYVHRDIKPENILVDRTGHIKLVDFG----SAAKMNSN----------KMVNAKL 256
+H G VHRD+KP+N+LV GHIKL DFG M +N + K
Sbjct: 494 YLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQ 553
Query: 257 PIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIM 316
GTP+Y+APEV+ + YG DWW++G+I YE + G PF T F ++
Sbjct: 554 VCGTPEYIAPEVIL------RQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI 607
Query: 317 NFQRFLKFPD-DPKVSSDFLDLIQSLL-CGQKERLKFEG---LCCHPFFSKIDWNNIRNS 371
+ + + +P+ D D DLI LL ERL G + H FF +DWN++
Sbjct: 608 SDE--INWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQ 665
Query: 372 PPPFVPTLKSDDDTSNFD--EPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYSKALGILG 429
F+P L+S+DDTS FD + + + + F+ E F S+
Sbjct: 666 KAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSH-------- 717
Query: 430 RSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQK 489
R V S +D + S+ EK +DS DK T SE +
Sbjct: 718 RFSKVFSSIDRITQNSAEEK---------EDSVDKTKSTTLPSTETLSWSSEYSEMQQLS 768
Query: 490 EVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK- 548
+E+ R L L L + + E D+A D E+ K
Sbjct: 769 TSNSSDTESNRHKLSSGL-------------LPKLAISTEGEQDEAASCPGDPHEEPGKP 815
Query: 549 ---LQEIKEQEYQ-----AQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK 600
+E ++E + + + L + E L RS+ +S S+ ++E
Sbjct: 816 ALPPEECAQEEPEVTTPASTISSSTLSVGSFSEHLDQINGRSECVDSTDNSSKPSSEPAS 875
Query: 601 RKATECQHKLLKAKDQGK 618
A + K K GK
Sbjct: 876 HMARQRLESTEKKKISGK 893
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 177 bits (450), Expect = 7e-44
Identities = 118/348 (33%), Positives = 175/348 (50%), Gaps = 31/348 (8%)
Query: 92 PSAK--DFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNIL 149
P AK DF+ ++G G F +V + + K G YA+KV++KK +L +++ ERN+L
Sbjct: 155 PHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVL 214
Query: 150 SRSTS-PWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILA 208
++ P++ L Y+FQ LY V+++ GG+L L R E E+ +FY AE+ A
Sbjct: 215 LKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQR-ERSFPEHRARFYAAEIASA 273
Query: 209 VHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEV 268
+ +H + V+RD+KPENIL+D GH+ L DFG + + GTP+Y+APEV
Sbjct: 274 LGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF-CGTPEYLAPEV 332
Query: 269 LTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDP 328
+ K Y DWW +G + YEM+YG PF A ++NI++ L+ P
Sbjct: 333 IR------KQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLR----P 382
Query: 329 KVSSDFLDLIQSLL-------CGQKERLKFEGLCCHPFFSKIDWNNI--RNSPPPFVPTL 379
VS +++ LL G KE F + HPFF + W ++ + PPPF P +
Sbjct: 383 GVSLTAWSILEELLEKDRQNRLGAKE--DFLEIQNHPFFESLSWADLVQKKIPPPFNPNV 440
Query: 380 KSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEEL-----PFVGFSYS 422
DD NFD V S C S + FVGFSY+
Sbjct: 441 AGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYA 488
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 177 bits (450), Expect = 7e-44
Identities = 118/348 (33%), Positives = 175/348 (50%), Gaps = 31/348 (8%)
Query: 92 PSAK--DFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNIL 149
P AK DF+ ++G G F +V + + K G YA+KV++KK +L +++ ERN+L
Sbjct: 155 PHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVL 214
Query: 150 SRSTS-PWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILA 208
++ P++ L Y+FQ LY V+++ GG+L L R E E+ +FY AE+ A
Sbjct: 215 LKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQR-ERSFPEHRARFYAAEIASA 273
Query: 209 VHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEV 268
+ +H + V+RD+KPENIL+D GH+ L DFG + + GTP+Y+APEV
Sbjct: 274 LGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF-CGTPEYLAPEV 332
Query: 269 LTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDP 328
+ K Y DWW +G + YEM+YG PF A ++NI++ L+ P
Sbjct: 333 IR------KQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLR----P 382
Query: 329 KVSSDFLDLIQSLL-------CGQKERLKFEGLCCHPFFSKIDWNNI--RNSPPPFVPTL 379
VS +++ LL G KE F + HPFF + W ++ + PPPF P +
Sbjct: 383 GVSLTAWSILEELLEKDRQNRLGAKE--DFLEIQNHPFFESLSWADLVQKKIPPPFNPNV 440
Query: 380 KSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEEL-----PFVGFSYS 422
DD NFD V S C S + FVGFSY+
Sbjct: 441 AGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYA 488
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 177 bits (449), Expect = 9e-44
Identities = 116/338 (34%), Positives = 185/338 (54%), Gaps = 24/338 (7%)
Query: 96 DFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTS- 154
DF+ ++G G++ +V + + K+ G YA+KV++KK++L +++ S ER++L ++
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
Query: 155 PWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHL 214
P++ L+Y+FQ LY V++Y GG+L L R E + E +FY AE+ A+ +H
Sbjct: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQR-ERRFLEPRARFYAAEVASAIGYLHS 152
Query: 215 MGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNG 274
+ ++RD+KPENIL+D GH+ L DFG K GTP+Y+APEVL
Sbjct: 153 LNIIYRDLKPENILLDCQGHVVLTDFG-LCKEGVEPEDTTSTFCGTPEYLAPEVLR---- 207
Query: 275 DGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDF 334
K Y DWW +G + YEM++G PF ++ + NI++ + L+ P V++
Sbjct: 208 --KEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH--QPLQIPGGRTVAA-- 261
Query: 335 LDLIQSLL-CGQKERL----KFEGLCCHPFFSKIDWNNI--RNSPPPFVPTLKSDDDTSN 387
DL+QSLL Q++RL F + H FFS I+W+++ + PPF P + D +
Sbjct: 262 CDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKH 321
Query: 388 FDEPEKNSWVSSSPCQLSP---SGFSGEELPFVGFSYS 422
FD PE S +P + SG F+GFSY+
Sbjct: 322 FD-PEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYA 358
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 177 bits (449), Expect = 9e-44
Identities = 116/338 (34%), Positives = 185/338 (54%), Gaps = 24/338 (7%)
Query: 96 DFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTS- 154
DF+ ++G G++ +V + + K+ G YA+KV++KK++L +++ S ER++L ++
Sbjct: 94 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 153
Query: 155 PWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHL 214
P++ L+Y+FQ LY V++Y GG+L L R E + E +FY AE+ A+ +H
Sbjct: 154 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQR-ERRFLEPRARFYAAEVASAIGYLHS 212
Query: 215 MGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNG 274
+ ++RD+KPENIL+D GH+ L DFG K GTP+Y+APEVL
Sbjct: 213 LNIIYRDLKPENILLDCQGHVVLTDFG-LCKEGVEPEDTTSTFCGTPEYLAPEVLR---- 267
Query: 275 DGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDF 334
K Y DWW +G + YEM++G PF ++ + NI++ + L+ P V++
Sbjct: 268 --KEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH--QPLQIPGGRTVAA-- 321
Query: 335 LDLIQSLL-CGQKERL----KFEGLCCHPFFSKIDWNNI--RNSPPPFVPTLKSDDDTSN 387
DL+QSLL Q++RL F + H FFS I+W+++ + PPF P + D +
Sbjct: 322 CDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKH 381
Query: 388 FDEPEKNSWVSSSPCQLSP---SGFSGEELPFVGFSYS 422
FD PE S +P + SG F+GFSY+
Sbjct: 382 FD-PEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYA 418
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,277,385
Number of Sequences: 37866
Number of extensions: 3603580
Number of successful extensions: 52083
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1105
Number of HSP's successfully gapped in prelim test: 1708
Number of HSP's that attempted gapping in prelim test: 18491
Number of HSP's gapped (non-prelim): 13789
length of query: 2027
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1909
effective length of database: 13,779,330
effective search space: 26304740970
effective search space used: 26304740970
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.