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Search of human proteins with 32528306
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32528306 replication factor C large subunit [Homo sapiens]
(1147 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32528306 replication factor C large subunit [Homo sapiens] 2255 0.0
gi|27501458 CTF18, chromosome transmission fidelity factor 18 ho... 98 4e-20
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 89 2e-17
gi|26080431 ATPase family, AAA domain containing 5 [Homo sapiens] 85 3e-16
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 77 9e-14
gi|87299628 biorientation of chromosomes in cell division 1-like... 71 5e-12
gi|104526627 triadin [Homo sapiens] 67 1e-10
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 66 2e-10
gi|41055989 M-phase phosphoprotein 8 [Homo sapiens] 62 2e-09
gi|6677723 replication factor C 5 isoform 1 [Homo sapiens] 61 5e-09
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 61 5e-09
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 61 5e-09
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 60 1e-08
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 60 1e-08
gi|31563534 replication factor C 2 isoform 1 [Homo sapiens] 60 1e-08
gi|6631100 natural killer-tumor recognition sequence [Homo sapiens] 59 2e-08
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 59 3e-08
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 59 3e-08
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap... 59 3e-08
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap... 59 3e-08
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 58 6e-08
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)... 56 2e-07
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)... 56 2e-07
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)... 56 2e-07
gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform... 55 3e-07
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 55 3e-07
gi|150170670 piccolo isoform 2 [Homo sapiens] 55 3e-07
gi|150378539 piccolo isoform 1 [Homo sapiens] 55 3e-07
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 55 4e-07
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 55 4e-07
>gi|32528306 replication factor C large subunit [Homo sapiens]
Length = 1147
Score = 2255 bits (5844), Expect = 0.0
Identities = 1147/1147 (100%), Positives = 1147/1147 (100%)
Query: 1 MDIRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPS 60
MDIRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPS
Sbjct: 1 MDIRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPS 60
Query: 61 KKKRIIYDSDSESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKK 120
KKKRIIYDSDSESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKK
Sbjct: 61 KKKRIIYDSDSESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKK 120
Query: 121 AASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKK 180
AASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKK
Sbjct: 121 AASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKK 180
Query: 181 MVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKK 240
MVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKK
Sbjct: 181 MVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKK 240
Query: 241 ARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHS 300
ARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHS
Sbjct: 241 ARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHS 300
Query: 301 KSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSS 360
KSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSS
Sbjct: 301 KSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSS 360
Query: 361 PAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLES 420
PAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLES
Sbjct: 361 PAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLES 420
Query: 421 IERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIR 480
IERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIR
Sbjct: 421 IERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIR 480
Query: 481 TMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSLAK 540
TMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSLAK
Sbjct: 481 TMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSLAK 540
Query: 541 TIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIG 600
TIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIG
Sbjct: 541 TIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIG 600
Query: 601 QQGDQSCANKLLRWLRNWQKSSSEDKKHAKFGKFSGKDDGSSFKAALLSGPPGVGKTTTA 660
QQGDQSCANKLLRWLRNWQKSSSEDKKHAKFGKFSGKDDGSSFKAALLSGPPGVGKTTTA
Sbjct: 601 QQGDQSCANKLLRWLRNWQKSSSEDKKHAKFGKFSGKDDGSSFKAALLSGPPGVGKTTTA 660
Query: 661 SLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSNGAASSVSTKHALIMDE 720
SLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSNGAASSVSTKHALIMDE
Sbjct: 661 SLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSNGAASSVSTKHALIMDE 720
Query: 721 VDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIK 780
VDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIK
Sbjct: 721 VDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIK 780
Query: 781 GAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCARSKALTYDQAKADSHRAK 840
GAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCARSKALTYDQAKADSHRAK
Sbjct: 781 GAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCARSKALTYDQAKADSHRAK 840
Query: 841 KDIKMGPFDVARKVFAAGEETAHMSLVDKSDLFFHDYSIAPLFVQENYIHVKPVAAGGDM 900
KDIKMGPFDVARKVFAAGEETAHMSLVDKSDLFFHDYSIAPLFVQENYIHVKPVAAGGDM
Sbjct: 841 KDIKMGPFDVARKVFAAGEETAHMSLVDKSDLFFHDYSIAPLFVQENYIHVKPVAAGGDM 900
Query: 901 KKHLMLLSRAADSICDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPS 960
KKHLMLLSRAADSICDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPS
Sbjct: 901 KKHLMLLSRAADSICDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPS 960
Query: 961 WLGKHSSTGKHDRIVQDLALHMSLRTYSSKRTVNMDYLSLLRDALVQPLTSQGVDGVQDV 1020
WLGKHSSTGKHDRIVQDLALHMSLRTYSSKRTVNMDYLSLLRDALVQPLTSQGVDGVQDV
Sbjct: 961 WLGKHSSTGKHDRIVQDLALHMSLRTYSSKRTVNMDYLSLLRDALVQPLTSQGVDGVQDV 1020
Query: 1021 VALMDTYYLMKEDFENIMEISSWGGKPSPFSKLDPKVKAAFTRAYNKEAHLTPYSLQAIK 1080
VALMDTYYLMKEDFENIMEISSWGGKPSPFSKLDPKVKAAFTRAYNKEAHLTPYSLQAIK
Sbjct: 1021 VALMDTYYLMKEDFENIMEISSWGGKPSPFSKLDPKVKAAFTRAYNKEAHLTPYSLQAIK 1080
Query: 1081 ASRHSTSPSLDSEYNEELNEDDSQSDEKDQDAIETDAMIKKKTKSSKPSKPEKDKEPRKG 1140
ASRHSTSPSLDSEYNEELNEDDSQSDEKDQDAIETDAMIKKKTKSSKPSKPEKDKEPRKG
Sbjct: 1081 ASRHSTSPSLDSEYNEELNEDDSQSDEKDQDAIETDAMIKKKTKSSKPSKPEKDKEPRKG 1140
Query: 1141 KGKSSKK 1147
KGKSSKK
Sbjct: 1141 KGKSSKK 1147
>gi|27501458 CTF18, chromosome transmission fidelity factor 18
homolog [Homo sapiens]
Length = 975
Score = 98.2 bits (243), Expect = 4e-20
Identities = 90/386 (23%), Positives = 152/386 (39%), Gaps = 75/386 (19%)
Query: 527 KKSRPTSKRDSLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLW 586
KK +R+ L + +K +D +E+ A+ + D+S + LW
Sbjct: 227 KKQVDGERRERLLQEAQKLSDTLHSLRSGEEEAAQPLGAPEEEPTDGQDASSH----CLW 282
Query: 587 VDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQ-------------KSSSEDKKHAKFGK 633
VD++ P ++ C LL+WL+ W + S E + +K
Sbjct: 283 VDEFAPRHYTELLSDDFTNRC---LLKWLKLWDLVVFGHERPSRKPRPSVEPARVSKEAT 339
Query: 634 FSGK------------------DDGSSFKAALLSGPPGVGKTTTASLVCQELGYSYVELN 675
GK K ALL GPPG+GKTT A ++ + GYS VE+N
Sbjct: 340 APGKWKSHEQVLEEMLEAGLDPSQRPKQKVALLCGPPGLGKTTLAHVIARHAGYSVVEMN 399
Query: 676 ASDTRSKSSLKAIVAESLNNTSIKGFYSNGAASSVSTKHALIMDEVDG--------MAGN 727
ASD RS + + + S+ G + + L++DE+DG +
Sbjct: 400 ASDDRSPEVFRTRIEAATQMESVLG--------AGGKPNCLVIDEIDGAPVAAINVLLSI 451
Query: 728 EDRGGIQEL------------------IGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDL 769
+R G QE+ GL+ PIIC+CND+ P +R L F L
Sbjct: 452 LNRKGPQEVGPQGPAVPSGGGRRRRAEGGLLMR---PIICICNDQFAPSLRQLKQQAFLL 508
Query: 770 RFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCARSKALTY 829
F ++ + ++ ++G++ P + + + DIR ++ L +R +
Sbjct: 509 HFPPTLPSRLVQRLQEVSLRQGMRADPGVLAALCEKTDNDIRACINTLQFLYSRGQRELS 568
Query: 830 DQAKADSHRAKKDIKMGPFDVARKVF 855
+ + KD + G F V ++VF
Sbjct: 569 VRDVQATRVGLKDQRRGLFSVWQEVF 594
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 89.0 bits (219), Expect = 2e-17
Identities = 135/593 (22%), Positives = 249/593 (41%), Gaps = 71/593 (11%)
Query: 84 KPPEKLPVSSKPGK----ISRQDPVTYISE-TDEEDDFMCKKAASKSKENGRSTNSHLGT 138
K EK+ V K K + Q T ++E EE++ K+ K +E G + G
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498
Query: 139 SNMKKN--EENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDES 196
K EE + + SP+K S + + + V S K S +E+
Sbjct: 499 EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 558
Query: 197 GLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSVQA 256
EA + + + + + + + A+ A E K+ + K E S +A
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA 618
Query: 257 NLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSP-KA 315
E+ K P +VK+ + K+ SP K+ E++ K+ + + E SP KA
Sbjct: 619 KSPVKEEAKSPAEVKSPE-----KAKSPTKE-------EAKSPEKAKSPEKEEAKSPEKA 666
Query: 316 SSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPEDS--- 372
S + + E + ++ A ++ +K E K+P+K KS P K+E+ SPE +
Sbjct: 667 KSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKS-PVKEEAKSPEKAKSP 725
Query: 373 --EKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLI 430
E+ +T +A +E K+ + P+ A+ + V + ++ ++EA+S
Sbjct: 726 VKEEAKTPEKAKSPV--KEEAKSPEKAKSPEKAKT-----LDVKSPEAKTPAKEEARSPA 778
Query: 431 ERYGGKVTGNV-------SKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMP 483
+++ K V K + L + + + K + + + +E+ + P
Sbjct: 779 DKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP 838
Query: 484 GKKSKYEIA---VETEMKKESKLERTPQK-----NVQGKR----------KISPSKKESE 525
KK++ E A +TE KK+SK E P+K V+ K+ K+ K+E+E
Sbjct: 839 PKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAE 898
Query: 526 SKKSRPTSKRDSLAKTIKKE-------TDVFWKSLDFKEQVAEETSGDSKARNLADDSSE 578
KK PT ++++ AK KE T+V K D + A+E S ++ + A + +
Sbjct: 899 DKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPD--DAKAKEPSKPAEKKEAAPEKKD 956
Query: 579 NKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLLR-WLRNWQKSSSEDKKHAK 630
K E ++ T K ++ D++ + + + +KSSS D+K +K
Sbjct: 957 TKEEKAKKPEEKPKTEAK---AKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSK 1006
Score = 47.4 bits (111), Expect = 8e-05
Identities = 74/316 (23%), Positives = 126/316 (39%), Gaps = 41/316 (12%)
Query: 14 KKLVSETVKKNEKTKSD--EETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDS 71
K V E K EK KS EE +K +K + E K K P K K + D S
Sbjct: 709 KSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPE---KAKSPEKAKTL--DVKS 763
Query: 72 ESEETLQVKNAKKPPEKLPVSSK-PGKISRQDPVTYISETDEE----DDFMCKKAASKS- 125
+T + A+ P +K P +K P K + P S E+ + + KK KS
Sbjct: 764 PEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823
Query: 126 -KENGRSTNSHLGTSNMKKNEENT---------KTKNKPLSPIKLTPTSVLDYFGTGSVQ 175
KE + + K EE K K +P K P ++ +V+
Sbjct: 824 VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 176 RSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDA------ELERQLHEDEEFA--- 226
+ + V +K++E EA AK +++ EDA E+ ++ +D +
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPEKEAPAK-VEVKEDAKPKEKTEVAKKEPDDAKAKEPS 942
Query: 227 -----RTLAMLDEEPKTKKARKDTEAGETFSSVQAN---LSKAEKHKYPHKVKTAQVSDE 278
+ A ++ K +KA+K E +T + + + LSK K + + +D+
Sbjct: 943 KPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQ 1002
Query: 279 RKSYSPRKQSKYESSK 294
+ S P K ++ +++K
Sbjct: 1003 KDSKPPEKATEDKAAK 1018
Score = 46.2 bits (108), Expect = 2e-04
Identities = 63/260 (24%), Positives = 106/260 (40%), Gaps = 26/260 (10%)
Query: 22 KKNEKTKSDEETLKAKKGIKEI-----KVNSSRKEDDFKQKQPSKKKRIIYDSDSESEET 76
K+ ++ +D+ KAK +KE K S KED ++ KK + E E+
Sbjct: 771 KEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKP 830
Query: 77 LQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSK--ENGRSTNS 134
+VK K+PP+K P ++ + D + + KK A K K E
Sbjct: 831 QEVK-VKEPPKKAEEEKAPATPKTEE------KKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 135 HLGTSNMKKNEENTKTKNKPLSPIKLTPTSV---LDYFGTGSVQRSNKKMVASKRKELSQ 191
S ++ +E + K K +P K P V D + + K+ +K KE S+
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSK 943
Query: 192 NTDESGL----NDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARK--DT 245
++ D K + +E + E + ED+ +TL+ +PK +KA K T
Sbjct: 944 PAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDD---KTLSKEPSKPKAEKAEKSSST 1000
Query: 246 EAGETFSSVQANLSKAEKHK 265
+ ++ +A KA K K
Sbjct: 1001 DQKDSKPPEKATEDKAAKGK 1020
Score = 37.0 bits (84), Expect = 0.11
Identities = 40/145 (27%), Positives = 54/145 (37%), Gaps = 35/145 (24%)
Query: 10 IPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSK---KKRII 66
+P+ +K V+ E K E+T AKK + DD K K+PSK KK
Sbjct: 903 VPTPEKEAPAKVEVKEDAKPKEKTEVAKK-----------EPDDAKAKEPSKPAEKKEAA 951
Query: 67 YDSDSESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSK 126
+ EE AKKP EK +K +EDD K SK K
Sbjct: 952 PEKKDTKEE-----KAKKPEEKPKTEAKA----------------KEDDKTLSKEPSKPK 990
Query: 127 ENGRSTNSHLGTSNMKKNEENTKTK 151
+S + K E+ T+ K
Sbjct: 991 AEKAEKSSSTDQKDSKPPEKATEDK 1015
Score = 32.7 bits (73), Expect = 2.0
Identities = 22/85 (25%), Positives = 44/85 (51%), Gaps = 4/85 (4%)
Query: 1067 KEAHLTPYSLQAIKASRHSTSPSLDS-EYNEELNEDDSQSDEKDQDAIETDAMIKKKTKS 1125
KE +P +++ + ++ T S E + +++++S EK + ++ +A +K KS
Sbjct: 623 KEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKS 682
Query: 1126 ---SKPSKPEKDKEPRKGKGKSSKK 1147
++ PEK K P K + KS +K
Sbjct: 683 PVKAEAKSPEKAKSPVKEEAKSPEK 707
>gi|26080431 ATPase family, AAA domain containing 5 [Homo sapiens]
Length = 1844
Score = 85.1 bits (209), Expect = 3e-16
Identities = 167/783 (21%), Positives = 317/783 (40%), Gaps = 116/783 (14%)
Query: 18 SETVKKNEKTKSDEETLKAKKGIKEI--KVNSSRKEDDFKQKQPSKKKRIIYDSDSESEE 75
S+ +K K SD++ +K + E+ NS + ++ + SK + +D S
Sbjct: 412 SDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFL 471
Query: 76 TLQVKNAKKPPEK------LPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENG 129
+ K KK +K +P ++ G +++ ++ E ++ ++ ++ ++
Sbjct: 472 KEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSS 531
Query: 130 RSTNSH------------LGTSNMKKNEENTKTKNKPLSPIKLTPT------SVLDYFGT 171
N+ L S++ N + ++ + P+ IKLT + S+L+
Sbjct: 532 TLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTP 591
Query: 172 GSVQRSNKKMVASKRKELSQNTDESGLNDEA-----IAKQLQLDED-----AELERQLHE 221
S +RS + + ++ E + D + D + K L E AEL +
Sbjct: 592 KSTRRSGR-ISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFD 650
Query: 222 DEEFARTLAMLDEEPKT--KKARKDTEAGETF-----------SSVQANLSKA----EKH 264
E R PK KK+ K +E E S+ N+SKA EK
Sbjct: 651 SESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKA 710
Query: 265 KYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKR 324
K H + ++V++E + R+ S++++ E ++ S++ I SSP A
Sbjct: 711 KALH-ISRSKVTEEI-AIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKH----PE 764
Query: 325 KEESSYKEIEPVASKRKENAIK-LKGETKTP---------KKTKSSPAKKESVSPEDSEK 374
K + + + V K+ + K + G+ K K P+ ES S + SEK
Sbjct: 765 KNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDES-SQDTSEK 823
Query: 375 KR---TNYQAYRSYLNREGPKALGSKEIPKGAE-NCLEGLIFVITGVLESIERDE----- 425
+ +A R +L P L + K A + + V+ ++D+
Sbjct: 824 SQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDGCCLW 883
Query: 426 -----AKSLIERYGGKVTGNVSKKTNYLVMGRDS---GQSKSDKAAALGTKIIDEDGLLN 477
+ L+ ++ T + + +G S + KS +AA+ + E
Sbjct: 884 HLKPPSCPLLTKFKELNTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKE--FTE 941
Query: 478 LIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDS 537
+R + ++ ++ E +KK L Q Q SK+E E+ S +KR
Sbjct: 942 EVRNLLLEEIRWSNP-EFSLKKYFPLLLKKQIEHQVLSSECHSKQELEADVSHKETKRKL 1000
Query: 538 L----AKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENK-VENLLWVDKYKP 592
+ +K+ +K+ + + K+L+ + +EE S + + + DSS++ E++LW +KY+P
Sbjct: 1001 VEAENSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQP 1060
Query: 593 TSLKTIIGQQGDQSCANKLLRWLRNWQKSSS----------EDKKHAKFG---KFSGKDD 639
+ +IG ++ KL WL++W++ + D+KH F F G D
Sbjct: 1061 QTASELIG---NELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSD 1117
Query: 640 GSS----FKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKSSLKAIVAESLNN 695
L++GP GVGKT QELG+ E+NAS RS + + + E+ +
Sbjct: 1118 DEEESRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQS 1177
Query: 696 TSI 698
+
Sbjct: 1178 HQV 1180
Score = 37.7 bits (86), Expect = 0.063
Identities = 142/658 (21%), Positives = 261/658 (39%), Gaps = 96/658 (14%)
Query: 17 VSETVKKNEK--TKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESE 74
V+E + N+ T S EE LK+ K K ++ S + + + Y S+SE+
Sbjct: 252 VTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENS 311
Query: 75 ETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNS 134
E Q K V P K + + P ++ + E + ++ R +N
Sbjct: 312 EISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNV 371
Query: 135 HLGTSNMKKN--EENTKTKNKPLSPIKLTPTSVLDYFGTGS-VQRSNKKMVASKRKELSQ 191
+ ++ E + KP ++ + + S ++ K + K+K+L++
Sbjct: 372 VIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNE 431
Query: 192 NT-DESGLNDEAIAKQLQLDEDAEL-----ERQLHEDEEFARTLAMLDEEPKT--KKARK 243
E G +D + K++ + ++ QLH D+ + L E+ K KK +K
Sbjct: 432 KCLYEVGRDDNS--KKIMENSGIQMVSKNGNLQLHTDKG-----SFLKEKNKKLKKKNKK 484
Query: 244 DTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESS----KESQQH 299
+ G + ++ ++ + K K Q R S RK ++SS ES +
Sbjct: 485 TLDTGAIPGKNREGNTQKKETTFFLKEKQYQ---NRMSLRQRKTEFFKSSTLFNNESLVY 541
Query: 300 SKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTK- 358
+ D + +VSS ++KL+ RK K+I+ SK + A L TPK T+
Sbjct: 542 EDIANDDLLKVSSLCNNNKLS---RKTSIPVKDIKLTQSKAESEASLLN--VSTPKSTRR 596
Query: 359 ----SSPAKKESVSPEDSEKKRTNYQAYRSY---LNREGPKALGSKE---IPKGAENCLE 408
SS E++ DS+ + N Q S N +L + E +P +E+ +
Sbjct: 597 SGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIR 656
Query: 409 GLIFVITGVLESIERDEAKS-LIERYGGKVTGNVSKKTNYLVMGRDSGQSKS--DKAAAL 465
I+ +S ++ +S E G T + K +N ++ ++K +KA AL
Sbjct: 657 MKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASN---TSKNISKAKQLIEKAKAL 713
Query: 466 G---TKIIDEDGL----LNLIRTMPGKKSKYEI------------AVETEMKKESKLE-- 504
+K+ +E + + +T+P +K E A++ K + KL+
Sbjct: 714 HISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCL 773
Query: 505 --------RTPQKNVQGKRKISP------SKKESESKKSRPTSKRDSLAKTIKKETDVFW 550
T KNV GK K++P ++K ++ S S +D+ K+ ++ DV
Sbjct: 774 NDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKS--QDCDVQC 831
Query: 551 KSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIG-QQGDQSC 607
K+ K D R +A ++ V N + TS + ++ QQ D C
Sbjct: 832 KA---KRDFLMSGLPDLLKRQIAKKAAALDVYNAV------STSFQRVVHVQQKDDGC 880
Score = 36.2 bits (82), Expect = 0.18
Identities = 127/652 (19%), Positives = 247/652 (37%), Gaps = 89/652 (13%)
Query: 14 KKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSES 73
KK V + + TKS T+ + + K++ ++DFK+ + K + ++ +
Sbjct: 162 KKQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVV-----DL 216
Query: 74 EETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTN 133
E+L + E+L + K GK ++Q T S + D+ +++ + S
Sbjct: 217 SESLPL------AEELNLLKKDGKDTKQMENT-TSHANSRDN------VTEAAQLNDSII 263
Query: 134 SHLGTSNMKKNEENTKTKNKPLSPIKL-TPTSVLDYFGTGSVQRSNKKMVASKRKELSQN 192
+ +K ++EN K + P S + + P+ +D + +S + S+ E+SQ
Sbjct: 264 TVSYEEFLKSHKEN-KVEEIPDSTMSICVPSETVD-----EIVKSG-YISESENSEISQQ 316
Query: 193 TDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLD-EEPKTKKARKDT----EA 247
+ A + + ++ R + ++F ++ D E +T + RK E
Sbjct: 317 VRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEE 376
Query: 248 GETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQS--KYESSKESQQHSKSSAD 305
+ ++A S+A K K + + + R+ S ++ K S K+ + K +
Sbjct: 377 ELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYE 436
Query: 306 KIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKE 365
+ +S K I + + + S KE KLK + K T + P K
Sbjct: 437 VGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNR 496
Query: 366 SVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDE 425
+ + +K+ T + + Y NR + ++ E L++ E I D+
Sbjct: 497 EGNTQ--KKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVY------EDIANDD 548
Query: 426 AKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAAL-------------------- 465
L++ +S+KT+ V QSK++ A+L
Sbjct: 549 ---LLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPT 605
Query: 466 --GTKIIDEDGL---------LNLIRTMPGKKSKY-----EIAVETEMKKESKLER--TP 507
+ ID D + + K S Y + ++E K R TP
Sbjct: 606 TETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTP 665
Query: 508 QKNVQGKRKISPSKK------ESESKKSRPTSKRDSLAK-TIKKETDVFWKSLDFKEQVA 560
+K+ + K S + S+ +K+ TSK S AK I+K + E++A
Sbjct: 666 KKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIA 725
Query: 561 EETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLL 612
S+ + L + ++ E+ + + PT+LK Q C N +L
Sbjct: 726 IPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVL 777
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 77.0 bits (188), Expect = 9e-14
Identities = 136/591 (23%), Positives = 234/591 (39%), Gaps = 72/591 (12%)
Query: 19 ETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKED----DFKQKQPSKKKRIIYDSDSESE 74
+ +K+ E+ + + +KA + +K + +E+ D K+K KK+ D+DSE
Sbjct: 57 DILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEEL 116
Query: 75 ETLQVKNAK--KPP-------------EKLPVSSKPGKISRQDPVTYISETDEEDDFMCK 119
E K+ K KP KLP +K GK + + SE DE++ K
Sbjct: 117 EDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAK-GKAQKSNKKWDGSEEDEDNSKKIK 175
Query: 120 KAA--SKSKENGRSTNSHLGT-SNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQR 176
+ + + S E+G ++ L + KKN+ KNKP I+ G
Sbjct: 176 ERSRINSSGESGDESDEFLQSRKGQKKNQ-----KNKPGPNIES---------GNEDDDA 221
Query: 177 SNK-KMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEE 235
S K K VA K+ E + E DE AK +L E ELE + + + +EE
Sbjct: 222 SFKIKTVAQKKAEKKER--ERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEE 279
Query: 236 PKTKKARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQS-KYESSK 294
K DT + A+ KAE P + D++K +K+ K E K
Sbjct: 280 TVKSKVTVDTGV------IPASEEKAET---PTAAEDDNEGDKKKKDKKKKKGEKEEKEK 330
Query: 295 ESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTP 354
E ++ + K + + K + KR+EE K +E + +KRKE +L+ E +
Sbjct: 331 EKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEE-RLEQEKRER 389
Query: 355 KKTKSSPAKKE-----SVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEG 409
KK K K+ + + + R +A L +G + +PK +
Sbjct: 390 KKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDK 449
Query: 410 LIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKI 469
I LES E E+ L G K+ + + + D +
Sbjct: 450 KRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAG------L 503
Query: 470 IDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKS 529
D + + + T + +K I V+ ++E + E +++ + S++E E +
Sbjct: 504 DDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEE-------SEEEEEEEGE 556
Query: 530 RPTSKRDSLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENK 580
S+ D + + E D K+LD K ++E S DS+ + D + E +
Sbjct: 557 SEGSEGDEEDEKVSDEKD-SGKTLDKKP--SKEMSSDSEYDSDDDRTKEER 604
Score = 38.9 bits (89), Expect = 0.028
Identities = 73/429 (17%), Positives = 162/429 (37%), Gaps = 54/429 (12%)
Query: 182 VASKRKELSQNTDESGLNDEAIAKQLQLDEDA--------------ELERQLHEDEEFAR 227
+ K+K S+++ + ++ +A+A +++ A E ++Q ++++ +
Sbjct: 1 MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK 60
Query: 228 TLAMLDEEPKTKKARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQ 287
L L E + KA ++T A + + + + +K K K K D K
Sbjct: 61 ELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD 120
Query: 288 SKYESSKESQQHSKSSADKIGEVSS--PKASSKLAIMKRKEESSYKEIEPVASKRKENAI 345
SK + + + + S +D + + KA K +K + S ++ ++N+
Sbjct: 121 SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEED--------EDNSK 172
Query: 346 KLKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAEN 405
K+K ++ +S E + +KK N+ GP I G E+
Sbjct: 173 KIKERSRINSSGESGDESDEFLQSRKGQKKNQK--------NKPGPN------IESGNED 218
Query: 406 CLEGLIFVITGVL---------ESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQ 456
+ F I V E +RDE K+ + + K KK +
Sbjct: 219 --DDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQ----SKQKES 272
Query: 457 SKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGK-R 515
+ + + +K+ + G++ + E E + KK+ K ++ +K + K +
Sbjct: 273 QRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEK 332
Query: 516 KISPSKKESESKKSRPTSKRDSLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADD 575
K PSK ++ + ++ + ++E + + + + + EE + + R
Sbjct: 333 KKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQ 392
Query: 576 SSENKVENL 584
+ + E L
Sbjct: 393 KEKERKERL 401
Score = 32.7 bits (73), Expect = 2.0
Identities = 18/48 (37%), Positives = 25/48 (52%), Gaps = 11/48 (22%)
Query: 1100 EDDSQSDEKDQDAIETDAMIKKKTKSSKPSKPEKDKEPRKGKGKSSKK 1147
EDD++ D+K KK K K K EK+KE +KG K++ K
Sbjct: 306 EDDNEGDKK-----------KKDKKKKKGEKEEKEKEKKKGPSKATVK 342
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 71.2 bits (173), Expect = 5e-12
Identities = 151/715 (21%), Positives = 275/715 (38%), Gaps = 117/715 (16%)
Query: 14 KKLVSETVKKNEKTKSDE--ETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDS 71
K+ SE + EK+ +D E L+ +E + ++ K I+ + D
Sbjct: 249 KERTSEDMADKEKSTADSGGEGLETAPKSEEFS-DLPCPVEEIKNYTKEHNNLILLNKDV 307
Query: 72 ESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRS 131
+ E + Q + EK P S++ G+ +K K K +
Sbjct: 308 QQESSEQKNKSTDKGEKKPDSNEKGE---------------------RKKEKKEKTEKKF 346
Query: 132 TNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNK-KMVASKRKELS 190
+S K +E + K K + +KL S + SNK K V +++ S
Sbjct: 347 DHSKKSEDTQKVKDEK-QAKEKEVESLKLP-----------SEKNSNKAKTVEGTKEDFS 394
Query: 191 Q-NTDESGLNDEAIAKQLQLD-----EDAELERQLHEDEEFARTLAMLDEEPKTKKARKD 244
++D GL D ++ D ED E E + E + D+E K K+ +
Sbjct: 395 LIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITS--DDEEKNKQNKTK 452
Query: 245 TEAGETFSSVQANLSKAEKHKYPHK----VKTAQVSDERKSYSPRKQSKYESSKESQQHS 300
T+ ++ +K+ +H Y HK K SD+ + R+QS + +E
Sbjct: 453 TQTSDS----SEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRR 508
Query: 301 KSSADKIGEVSSPKA----SSKLAIMKRK----EESSYKEIEPVASKRKENAIKLKGETK 352
+ + +K+ E KA SSK R EESS K +EP A++ KE + + +
Sbjct: 509 QINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKE--VLKERKVL 566
Query: 353 TPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIF 412
K S KK+S + E++ KK+ Y+ SKE K +E+C + I
Sbjct: 567 EKKVALSKKRKKDSRNVEENSKKKQQYEE-------------DSKETLKTSEHCEKEKI- 612
Query: 413 VITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDE 472
+ ++ AKS K +S+ + + ++ + + + T +I E
Sbjct: 613 ---SSSKELKHVHAKS----EPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIME 665
Query: 473 DGLLNLIRTMPGKK--SKYEIAVETEMKKESKLE----------RTPQKNVQGKRKISPS 520
G+ T K+ + EI E K++S L+ TP K+++ S
Sbjct: 666 -GVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSS 724
Query: 521 KKESESKKSRPTSKRDSLAKTIKKETDVFWKSLDFKE--------QVAEETSGDSKARNL 572
K++ E +K T D L+ K + D K+ D E +V E S+ L
Sbjct: 725 KEKPEREK---TPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKL 781
Query: 573 -ADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDKKHAKF 631
+DD +E K K++ +++G+ G + + +++ N +K +++ ++
Sbjct: 782 SSDDKTERK-------SKHRNERKLSVLGKDG-KPVSEYIIKTDENVRKENNKKERRLSA 833
Query: 632 GKFSGKDDGSSFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKSSLK 686
K + + + K +L + YS + + T S+LK
Sbjct: 834 EKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLK 888
Score = 61.6 bits (148), Expect = 4e-09
Identities = 112/538 (20%), Positives = 217/538 (40%), Gaps = 79/538 (14%)
Query: 23 KNEK--TKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRII---YDSD-----SE 72
KNEK K D ET K +K+ +V SS+++ + ++K PS+ K + Y D +
Sbjct: 698 KNEKHLKKDDSETPHLKSLLKK-EVKSSKEKPE-REKTPSEDKLSVKHKYKGDCMHKTGD 755
Query: 73 SEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRST 132
E + K E + S+ K+S D +T+ + ++ S ++G+
Sbjct: 756 ETELHSSEKGLKVEENIQKQSQQTKLSSDD------KTERKSKHRNERKLSVLGKDGKPV 809
Query: 133 NSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELS-Q 191
+ ++ +K +E K NK + T S + K + SK+ ++ Q
Sbjct: 810 SEYI----IKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQ 865
Query: 192 NTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEE----PKTKKARKDTEA 247
ES D+ +D + + E +H+++ RT ++L+E+ K+K K +
Sbjct: 866 RRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKR--RTKSLLEEKLVLKSKSKTQGKQVKV 923
Query: 248 GETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKI 307
ET +Q +K P K K + +D K + +S E + ++ + +
Sbjct: 924 VET--ELQEGATKQATTPKPDKEKNTEENDSEK--------QRKSKVEDKPFEETGVEPV 973
Query: 308 GEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKE-- 365
E +S A S +++SS++ P+A KE K T T + K S K
Sbjct: 974 LETASSSAHS------TQKDSSHRAKLPLA---KEKYKSDKDSTSTRLERKLSDGHKSRS 1024
Query: 366 -SVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERD 424
S +D +KK N +++G + S E +G + + E+
Sbjct: 1025 LKHSSKDIKKKDENKSD-----DKDGKEVDSSHEKARGNSSLM--------------EKK 1065
Query: 425 EAKSLIERYGGKVTGNVSKKTNYL---VMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRT 481
++ L E G ++ ++K L + SG S + +I E + I +
Sbjct: 1066 LSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPME-IDS 1124
Query: 482 MPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKE-----SESKKSRPTSK 534
PG ++ +E++ + + + + +N++ K + K E ++SK + P K
Sbjct: 1125 EPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYK 1182
Score = 40.4 bits (93), Expect = 0.010
Identities = 105/505 (20%), Positives = 189/505 (37%), Gaps = 42/505 (8%)
Query: 22 KKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKN 81
KK+E D++ + ++ + NSS E ++ ++ + ++ EE L
Sbjct: 1034 KKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANT 1093
Query: 82 AKKPP-EKLPVSSKPGK---ISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSH-- 135
P L K G I Q+P+ SE E+ F SK+++N R+ NS
Sbjct: 1094 LSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVF----EVSKTQDN-RNNNSQQD 1148
Query: 136 LGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYF-GTGSVQRSNKKMVASKRKELSQNTD 194
+ + NMK+ T K++ + + + Y G G+ SN + A R L++
Sbjct: 1149 IDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKK-- 1206
Query: 195 ESGLNDEAIAKQLQLDEDAELER---QLHEDEEFAR--TLAMLDEEPKTKKARKDTEAGE 249
++ ++ ++ E + R +++ D E L+ E + +K K+T A E
Sbjct: 1207 ---MHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAEE 1263
Query: 250 TFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSK--ESQQHSKSSADKI 307
+ A L + + + V R+SY P ++ E S S AD
Sbjct: 1264 HVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSPADHS 1323
Query: 308 GEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESV 367
+ + ++K + E V + K + + + + T + + +
Sbjct: 1324 ALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVI 1383
Query: 368 SPEDSEKKRTNYQAYRSYLNREGPKA-LGSKEIPKGAENCLEGLI--FVITGVLESIERD 424
P S K T + +EG + KE AE L+ I V G + I D
Sbjct: 1384 MPLGS--KLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKATVENGKKDGIAVD 1441
Query: 425 EAKSL-IERYGGKV-------TGNVSKKTNYLVMGRDSGQSKSDKAAALGTK---IIDED 473
L E+Y V G V K + + R + S+ D +A G+ + +
Sbjct: 1442 HVVGLNTEKYAETVKLKHKRSPGKV--KDISIDVERRNENSEVDTSAGSGSAPSVLHQRN 1499
Query: 474 GLLNLIRTMPGKKSKYEIAVETEMK 498
G + T P + K +A TE K
Sbjct: 1500 GQTEDVATGPRRAEKTSVATSTEGK 1524
Score = 35.0 bits (79), Expect = 0.41
Identities = 52/358 (14%), Positives = 138/358 (38%), Gaps = 38/358 (10%)
Query: 12 SGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDS 71
+ +++ SE+ K E + ++ +A G ++ + E++ + K+K+ S+
Sbjct: 2724 TNEEIHSESYNKGEISSGRKDNAEAISG-HSVEADPKEVEEEERHMPKRKRKQHYLSSED 2782
Query: 72 ESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRS 131
E ++ V + S+ RQ P T +T EE+ ++ S E +
Sbjct: 2783 EPDDNPDV-----------LDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNST 2831
Query: 132 TNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQ 191
T+ + + + E T K + T Q ++ ++ +++ +
Sbjct: 2832 TSRVMEEKDEYSSSETTGEKPEQNDD------------DTIKSQEEDQPIIIKRKRGRPR 2879
Query: 192 NTDESGLNDEAIAKQLQLDEDAELERQLH--EDEEFARTLAMLDEEPKTKKARKDTEAGE 249
+ L++ +D++ + + E + L ++ + K+ E
Sbjct: 2880 KYP--------VETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSI 2931
Query: 250 TFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSP---RKQSKYESSKESQQHSKSSADK 306
+ + + + + + ++ VSD+ +S P R++S + ++ ++ ++
Sbjct: 2932 SNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEE 2991
Query: 307 IGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKK 364
E P ++ + + + + S ++ P + KRK T+ ++ + +P KK
Sbjct: 2992 EEEEDEPSGATTRSTTRSEAQRSKTQLSP-SIKRKREVSPPGARTRGQQRVEEAPVKK 3048
Score = 32.0 bits (71), Expect = 3.5
Identities = 66/335 (19%), Positives = 128/335 (38%), Gaps = 57/335 (17%)
Query: 289 KYESSKESQQHSKSSADKIGEVSSPKAS------SKLAIMKRK----------EESSYKE 332
K +++ + + + S +K GE+ +P S S +A ++R+ E S ++
Sbjct: 2665 KLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRT 2724
Query: 333 IEPVASKRKENAIKLKGETKTPKKTKSSPAKKESVSP-----EDSEKKRTNYQAYRSYLN 387
E + S+ KGE + +K + SV E+ E+ + + YL+
Sbjct: 2725 NEEIHSESYN-----KGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLS 2779
Query: 388 RE-----GPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVS 442
E P L S+ I C E E + E S K + +
Sbjct: 2780 SEDEPDDNPDVLDSR-IETAQRQCPE---------TEPHDTKEENSRDLEELPKTSSETN 2829
Query: 443 KKTNYLVMGRD---SGQSKSDKAAALGTKII--DEDGLLNLIRTMPGKKSKYEIAVETEM 497
T+ ++ +D S ++ +K I E+ +I+ G+ KY + +M
Sbjct: 2830 STTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKM 2889
Query: 498 KKESK-------LERTPQKNVQGKRKISPSKKESESKKSRPTSKRD---SLAKTIKKETD 547
K +SK +E++P + + S KE+ + + R S D + ++++
Sbjct: 2890 KDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGR 2949
Query: 548 VFWKSLDFKEQVAEETSGDSKARNLADDSSENKVE 582
+SL + AE + + K + D E+K E
Sbjct: 2950 KPKRSLTVSDD-AESSEPERKRQKSVSDPVEDKKE 2983
Score = 30.8 bits (68), Expect = 7.7
Identities = 24/74 (32%), Positives = 33/74 (44%), Gaps = 8/74 (10%)
Query: 1081 ASRHSTSPSLDSEYNEELNEDDSQSDEK--DQDAIETDAMIKKKTKSSKPSKPEKDKEPR 1138
A++ +T+P D E N E N+ + Q K D+ ET +T SS +KD R
Sbjct: 932 ATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHR 991
Query: 1139 ------KGKGKSSK 1146
K K KS K
Sbjct: 992 AKLPLAKEKYKSDK 1005
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 67.0 bits (162), Expect = 1e-10
Identities = 107/569 (18%), Positives = 213/569 (37%), Gaps = 54/569 (9%)
Query: 25 EKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKK 84
E DE+T K + ++ K+ KQ++P +K + + + +V+ +K
Sbjct: 120 EDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEK 179
Query: 85 PPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKN 144
P +K K K ++ P T +++ +K+ K+K+ + K
Sbjct: 180 PEKKATHKEKIEK--KEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKV 237
Query: 145 EENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIA 204
+E KT +KP + +K SK ++ Q + D +
Sbjct: 238 KEVQKTPSKP------------------KEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVH 279
Query: 205 KQLQLDEDAELERQLHEDEEFARTLA--MLDEEPKTKKARKDTEAGETFSSVQANLSKAE 262
L+ + + L ++ T A L+E+ KK + ET + ++ K
Sbjct: 280 GDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKS 339
Query: 263 KHKYPHKV--KTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLA 320
+ + V K + E K + + ++ + K+ ++ K EV PK
Sbjct: 340 EKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKG----- 394
Query: 321 IMKRKEESSYKEIEPVASKRKENAI----KLKGETKTPKKTKSSPAKKESVSPEDSEK-K 375
+K+E K +EP S +KE+++ ++K +T+ K+ + + K++V + EK
Sbjct: 395 ---KKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTT 451
Query: 376 RTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGG 435
+T Q R + + L KE KG E V S++ E ++ +
Sbjct: 452 KTVEQEIRKEKSGKTSSILKDKEPIKGKEE----------KVPASLKEKEPETKKDEKMS 501
Query: 436 KVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVET 495
K V K L Q K ++ K + + ++ K E V
Sbjct: 502 KAGKEVKPKPPQL-------QGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSH 554
Query: 496 EMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIKKETDVFWKSLDF 555
+E L++ ++ K P+KK ++ P+ K D T K ++V
Sbjct: 555 GKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKK 614
Query: 556 KEQVAEETSGDSKARNLADDSSENKVENL 584
E +E+ + ++L ++ + E+L
Sbjct: 615 TEISEKESKEKADMKHLREEKVSTRKESL 643
Score = 59.3 bits (142), Expect = 2e-08
Identities = 90/417 (21%), Positives = 161/417 (38%), Gaps = 45/417 (10%)
Query: 234 EEPKTKKARKDTEAGET----FSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSK 289
E+ + +DT+ GE + + K EK + P + +V+ + K K +
Sbjct: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVRE 176
Query: 290 YESSKESQQHSKS--SADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKR-KENAIK 346
E ++ H + +K + K K ++ EE + KE++ ++ K+ A K
Sbjct: 177 KEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAK 236
Query: 347 LKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALG-SKEIPKGAEN 405
+K KTP K K K+++ + +K + + Y + G G S IP
Sbjct: 237 VKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPT 296
Query: 406 CLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAAL 465
+ LE E ++ K+ KVT KK ++ + KS+K A+
Sbjct: 297 EQASRPTPASPALEEKEGEKKKA-----EKKVTSETKKKE------KEDIKKKSEKETAI 345
Query: 466 GTKIIDEDGLLNLIRTMPGKKSK-----YEIAVETEMKKESKLERTPQKNVQGKRKISPS 520
+ + PGK S+ +IA + KK+ K E + K K
Sbjct: 346 DVE-----------KKEPGKASETKQGTVKIAAQAAAKKDEKKEDSK------KTKKPAE 388
Query: 521 KKESESKKSRPTSKRDSLAKTIKKETDV-FWKSLDFKEQVAEETSGDSKARNLADDSSEN 579
++ + KK K AK+ KKE V K + K + A+E G + E
Sbjct: 389 VEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEE 448
Query: 580 KVENLLWVDKYKPTSLKT---IIGQQGDQSCANKLLRWLRNWQKSSSEDKKHAKFGK 633
K + + K S KT + ++ + K+ L+ + + +D+K +K GK
Sbjct: 449 KTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGK 505
Score = 58.9 bits (141), Expect = 3e-08
Identities = 107/496 (21%), Positives = 180/496 (36%), Gaps = 54/496 (10%)
Query: 11 PSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSD 70
P K L E K KS+E+T K KG K+ KV + + QK PSK K
Sbjct: 196 PETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPK-----EK 250
Query: 71 SESEETLQVKNAKK------------------PPEKLPVSSKPGKISRQDPVTYISETDE 112
+ E+ K+ +K P + P P + T S E
Sbjct: 251 EDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALE 310
Query: 113 EDDFMCKKAASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPT--SVLDYFG 170
E + KKA K + KK+E+ T + P K + T +
Sbjct: 311 EKEGEKKKAEKKVTSETKKKEKE---DIKKKSEKETAIDVEKKEPGKASETKQGTVKIAA 367
Query: 171 TGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLA 230
+ ++ KK + K K+ ++ G E K ++ + + E + D++
Sbjct: 368 QAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTE 427
Query: 231 MLDEE---PKTKKARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQ 287
EE KKA + +T +V+ + K + KT+ + +++ +++
Sbjct: 428 RAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSG------KTSSILKDKEPIKGKEE 481
Query: 288 SKYESSKESQQHSK--SSADKIGEVSSPKASSKLAIMKRKEESSY-KEIEPVASKR---- 340
S KE + +K K G+ PK + K E KE +P S++
Sbjct: 482 KVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIH 541
Query: 341 KENAIKLKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGP--KALGSKE 398
K++ +K + K + + ++V+ E + K + +A + RE P K K
Sbjct: 542 KQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKA--EHREREPPSIKTDKPKP 599
Query: 399 IPKGAENCLE-GLIFVITGVLESIERDEAKSLIE-----RYGGKVTGNVSKKTNYLVMGR 452
PKG E G ES E+ + K L E R NV+K + +
Sbjct: 600 TPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSK 659
Query: 453 DSGQSKSDKAAALGTK 468
D + K A GT+
Sbjct: 660 DVEDVPASKKAKEGTE 675
Score = 48.5 bits (114), Expect = 4e-05
Identities = 90/395 (22%), Positives = 149/395 (37%), Gaps = 53/395 (13%)
Query: 14 KKLVSETVKKNE---KTKSDEETL------------KAKKGIKEIKVNSSRKEDDFKQKQ 58
KK+ SET KK + K KS++ET + K+G +I ++ K+D+ K+
Sbjct: 321 KKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDS 380
Query: 59 PSKKKRIIYDSDSESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMC 118
KK +E E+ K KK P S P K E D
Sbjct: 381 KKTKK------PAEVEQPKGKKQEKKEKHVEPAKS-PKK-----------EHSVPSDKQV 422
Query: 119 KKAASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSN 178
K ++KE + + KK E+ TKT + + K TS + +
Sbjct: 423 KAKTERAKEEIGAVSIKKAVPG-KKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEE 481
Query: 179 KKMVASKRKELSQNTDE----SGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDE 234
K + K KE DE +G + QLQ ++ + E Q+ ++ + A + +
Sbjct: 482 KVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIH 541
Query: 235 EPKTKKARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPR-KQSKYESS 293
+ K K G+ V + KA + K K + ++ R+ P K K + +
Sbjct: 542 KQDIVKPEKTVSHGKPEEKVLKQV-KAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPT 600
Query: 294 KESQQHSKSSADKIGEVSSPKASSKLAIMKRKEE--SSYKEIEPVASKRKENAIKLKGET 351
+ S K E+S ++ K + +EE S+ KE S + N K +
Sbjct: 601 PKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKE-----SLQLHNVTKAEKPA 655
Query: 352 KTPKKTKSSPAKK------ESVSPEDSEKKRTNYQ 380
+ K + PA K E VSP + + +Q
Sbjct: 656 RVSKDVEDVPASKKAKEGTEDVSPTKQKSPISFFQ 690
Score = 30.8 bits (68), Expect = 7.7
Identities = 21/63 (33%), Positives = 30/63 (47%), Gaps = 10/63 (15%)
Query: 1095 NEELNEDDSQSDEKDQDAIETDAMIKK---KTKSSKPSKPEK-------DKEPRKGKGKS 1144
+ E EDD ++ D+ I+ + KK K K+ K KPE+ KE KGK K
Sbjct: 115 SSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKV 174
Query: 1145 SKK 1147
+K
Sbjct: 175 REK 177
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 66.2 bits (160), Expect = 2e-10
Identities = 92/534 (17%), Positives = 218/534 (40%), Gaps = 68/534 (12%)
Query: 18 SETVKKNEKTKSDEETLKAKKGIKEIK---------VNSSRKEDDFKQKQPSKKKRIIYD 68
+ET +K EK++S +E + ++ K ++KED K+++ +K +
Sbjct: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203
Query: 69 SDSESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKEN 128
+++ E ++ K + E + +S K G+IS ++P + +EE +E
Sbjct: 204 GENQVEVMVEEKTTESQEETVVMSLKNGQISSEEP-----KQEEE------------REQ 246
Query: 129 GRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKE 188
G SH + K EE+ + + ++ +++ A + K+
Sbjct: 247 GSDEISH----HEKMEEEDKERAEAERARLE---------------AEERERIKAEQDKK 287
Query: 189 LSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAML-DEEPKTKKARKDTEA 247
++ ++A A++ + E E ER E++ A + +EE + + R+ +
Sbjct: 288 IADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKE 347
Query: 248 GETFSSVQANLSKAEKHKYPHKVKTAQVSDERKS--YSPRKQSKYESSKESQQHSKSSAD 305
E ++ + K E+ + + + A+ +E K+ ++ + E K + Q +K +
Sbjct: 348 EEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
Query: 306 KIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPA-KK 364
K+ + K K K+ +E +++ K++ K + K K + P KK
Sbjct: 408 KVEQ----KIEGKWVNEKKAQED---KLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKK 460
Query: 365 ESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERD 424
E + E +K + + +S+++R+ K + G E + + + R
Sbjct: 461 EEIKDEKIKKDKEPKEEVKSFMDRK--KGFTEVKSQNG-----EFMTHKLKHTENTFSRP 513
Query: 425 EAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPG 484
++ ++ + V + R G+++S++ L K ++ L L
Sbjct: 514 GGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQK--QQEAALELEELKKK 571
Query: 485 KKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSL 538
++ + ++ E E +++ + + + KR++ K+E E +++ KR +
Sbjct: 572 REERRKVLEEEEQRRKQEEADRKLREEEEKRRL---KEEIERRRAEAAEKRQKM 622
Score = 45.4 bits (106), Expect = 3e-04
Identities = 80/457 (17%), Positives = 184/457 (40%), Gaps = 79/457 (17%)
Query: 187 KELSQNTDESGLNDEAIAKQLQLDEDAE---LERQLHEDEEFARTLAMLDEEPKTKKARK 243
K + NT G ++ A ++L E+ L+ L +EF T+ +++ +
Sbjct: 80 KTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQN 139
Query: 244 DTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYE-SSKESQQHSKS 302
DT ET + + S+ E+++ + +T S ++ + +++K E KE ++ K
Sbjct: 140 DTAENETTEKEEKSESRQERYEI-EETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKP 198
Query: 303 SADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPA 362
IGE +++ +M +E+++ + E V K I + + ++ + S
Sbjct: 199 KRGSIGE-------NQVEVMV-EEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDE 250
Query: 363 KKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIE 422
E+ +K+R +A R+ L E + + +++ K A+ IE
Sbjct: 251 ISHHEKMEEEDKERA--EAERARLEAEERERIKAEQDKKIADE------------RARIE 296
Query: 423 RDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTM 482
+E + ER + R+ + + +AA +I +E+
Sbjct: 297 AEEKAAAQERERREAE------------ERERMREEEKRAAEERQRIKEEE--------- 335
Query: 483 PGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSLAKTI 542
+ ++ +++ ++ + +++I +K + ++ R ++ + AK
Sbjct: 336 -----------KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVE 384
Query: 543 KKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLK---TII 599
+++ + K L+ K+ +ET + + E K+E WV++ K K ++
Sbjct: 385 EQKRN---KQLEEKKHAMQET-------KIKGEKVEQKIEG-KWVNEKKAQEDKLQTAVL 433
Query: 600 GQQGD------QSCANKLLRWLRNWQKSSSEDKKHAK 630
+QG+ Q+ KL ++K +D+K K
Sbjct: 434 KKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKK 470
Score = 40.0 bits (92), Expect = 0.013
Identities = 90/421 (21%), Positives = 151/421 (35%), Gaps = 77/421 (18%)
Query: 19 ETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQ 78
E K E+ K +++ + K ++E K+ + E + K ++KK E+ LQ
Sbjct: 378 EEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKA--------QEDKLQ 429
Query: 79 VKNAKKPPEK--LPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHL 136
KK E+ V +K K+ P E +E K KE S +
Sbjct: 430 TAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEK-------IKKDKEPKEEVKSFM 482
Query: 137 GTSNMKKNEENTKTKNKPLSPIKL--TPTSVLDYFGTGSVQRSNKK----MVASKR-KEL 189
+ KK K++N KL T + G SV + + A KR +EL
Sbjct: 483 ---DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEEL 539
Query: 190 SQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGE 249
+ E+ + KQ Q + ELE + EE + L ++ K ++A + E
Sbjct: 540 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE 599
Query: 250 TFSSVQANLSK--AEKHKYPHKVKTAQVSDERKSYS--PRKQSKYESSKESQQHSKSSAD 305
++ + + AE + K+ +SD++K + K S + + ++ +KS
Sbjct: 600 EKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQK 659
Query: 306 KIGEVSSPKASSKLAIMKRKEE--------SSYKEIEPVASK--------RKENAIKLKG 349
G S+ +A+ I R E+ S K +P AS R ++ KG
Sbjct: 660 SSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKG 719
Query: 350 E------------------------------TKTPKKTKSSPAKKESVSPEDSEKKRTNY 379
TKTP KS K + P D KR +
Sbjct: 720 NVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLW 779
Query: 380 Q 380
+
Sbjct: 780 E 780
>gi|41055989 M-phase phosphoprotein 8 [Homo sapiens]
Length = 860
Score = 62.4 bits (150), Expect = 2e-09
Identities = 83/388 (21%), Positives = 154/388 (39%), Gaps = 52/388 (13%)
Query: 14 KKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSES 73
+K ++E K + + D + L I E +S ++ + + P KKK+ + + +S
Sbjct: 107 RKKIAEN--KAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKS 164
Query: 74 EETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTN 133
+ L+ K AK KL SKP S + + + D KK S++KE + +
Sbjct: 165 PDDLKKKKAKAG--KLKDKSKPDLESSLESLVF--------DLRTKKRISEAKEELKESK 214
Query: 134 SHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNT 193
+K+ +E K K + +K T + N+K K E +
Sbjct: 215 KPK-KDEVKETKELKKVKKGEIRDLKTK---------TREDPKENRKTKKEKFVESQVES 264
Query: 194 DESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSS 253
+ S LND ++D+E LH D +E+ TK AR+
Sbjct: 265 ESSVLNDSPFP-----EDDSE---GLHSDSR--------EEKQNTKSARE---------- 298
Query: 254 VQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSP 313
+A +H + + +A ++E R++ K E + ++ +K +
Sbjct: 299 -RAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKK 357
Query: 314 KASSKLAIMKR-KEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPEDS 372
K R K + +++ PV+++ + +L GE + T S+ KE+ E
Sbjct: 358 TVPKKQRNQDRSKSAAELEKLMPVSAQTPKGR-RLSGEERGLWSTDSAEEDKETKRNESK 416
Query: 373 EKKRTNYQAYRSYLNREGPKALGS-KEI 399
EK + + + + R+ PK L + KEI
Sbjct: 417 EKYQKRHDSDKEEKGRKEPKGLKTLKEI 444
Score = 32.7 bits (73), Expect = 2.0
Identities = 54/258 (20%), Positives = 111/258 (43%), Gaps = 29/258 (11%)
Query: 290 YESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKG 349
+E++ +S Q S++ D +SPK K ++++EE S +++ K+K A KLK
Sbjct: 132 FEANSDSDQQSETKED-----TSPKKKKKK--LRQREEKSPDDLK----KKKAKAGKLKD 180
Query: 350 ETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEG 409
++K ++ ES+ + KKR + +A + PK KE K + +G
Sbjct: 181 KSKPDLESSL-----ESLVFDLRTKKRIS-EAKEELKESKKPKKDEVKET-KELKKVKKG 233
Query: 410 LIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKI 469
I + ++ K+ E++ V V +++ L + D + L +
Sbjct: 234 EIRDLKTKTREDPKENRKTKKEKF---VESQVESESSVL----NDSPFPEDDSEGLHSDS 286
Query: 470 IDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKS 529
+E R G+ E E + +S + +V+G+RK +K +++++
Sbjct: 287 REEKQNTKSARERAGQDMGLEHGFEKPL--DSAMSAEEDTDVRGRRKKKTPRKAEDTREN 344
Query: 530 RPTSKRDSL--AKTIKKE 545
R +++ KT+ K+
Sbjct: 345 RKLENKNAFLEKKTVPKK 362
Score = 32.3 bits (72), Expect = 2.7
Identities = 61/297 (20%), Positives = 115/297 (38%), Gaps = 38/297 (12%)
Query: 14 KKLVSET---VKKNEKTKSDE-----ETLKAKKG-IKEIKVNSSRKEDDFKQKQPSKKKR 64
KK +SE +K+++K K DE E K KKG I+++K + +ED + ++ K+K
Sbjct: 200 KKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKT--REDPKENRKTKKEKF 257
Query: 65 IIYDSDSESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASK 124
+ +S+ E V N PE D S++ EE
Sbjct: 258 V----ESQVESESSVLNDSPFPE-------------DDSEGLHSDSREEKQNTKSARERA 300
Query: 125 SKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVAS 184
++ G + EE+T + + K TP D ++ N +
Sbjct: 301 GQDMGLEHGFEKPLDSAMSAEEDTDVRGRRK---KKTPRKAEDTRENRKLENKNAFLEKK 357
Query: 185 KRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKD 244
+ +N D S E + K + + R+L +E + +E+ +TK+
Sbjct: 358 TVPKKQRNQDRSKSAAE-LEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKR---- 412
Query: 245 TEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSK 301
E+ E + + + + K P +KT + + R ++ K + E + S+ + K
Sbjct: 413 NESKEKYQKRHDSDKEEKGRKEPKGLKT--LKEIRNAFDLFKLTPEEKNDVSENNRK 467
>gi|6677723 replication factor C 5 isoform 1 [Homo sapiens]
Length = 340
Score = 61.2 bits (147), Expect = 5e-09
Identities = 69/288 (23%), Positives = 113/288 (39%), Gaps = 52/288 (18%)
Query: 566 DSKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSED 625
++ A + + K+ NL WV+KY+P +L +I Q S K + +ED
Sbjct: 2 ETSALKQQEQPAATKIRNLPWVEKYRPQTLNDLISHQDILSTIQKFI----------NED 51
Query: 626 KKHAKFGKFSGKDDGSSFKAALLSGPPGVGKTTTASLVC-------QELGYSYVELNASD 678
+ LL GPPG GKT+T L C +E G +ELNASD
Sbjct: 52 R----------------LPHLLLYGPPGTGKTSTI-LACAKQLYKDKEFGSMVLELNASD 94
Query: 679 TRSKSSLKAIVAESLNNTSI--KGFYSNGAASSVSTKHALIMDEVDGMAGNEDRGGIQEL 736
R ++ + + +I KGF +I+DE D M + + +
Sbjct: 95 DRGIDIIRGPILSFASTRTIFKKGF------------KLVILDEADAMTQDAQNALRRVI 142
Query: 737 IGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPP 796
++T+ +IC + P ++S C RF E + + + +E + I
Sbjct: 143 EKFTENTRFCLICNYLSKIIPALQS---RCTRFRFGPLTPELMVPRLEHVVEEEKVDISE 199
Query: 797 PAMNEIILGANQDIRQVLHNL-SMWCARSKALTYDQAKADSHRAKKDI 843
M ++ ++ D+R+ L+ L S A K H K DI
Sbjct: 200 DGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGHPLKSDI 247
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 61.2 bits (147), Expect = 5e-09
Identities = 123/645 (19%), Positives = 245/645 (37%), Gaps = 126/645 (19%)
Query: 14 KKLVSETVKKN--EKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDS 71
K + E VKK+ + KS++ T K +K K + N K+K+ +++K + D +S
Sbjct: 1069 KPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFES 1128
Query: 72 ESEE--TLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASK---SK 126
S + L+V KP K + K+ R T E+D A K ++
Sbjct: 1129 SSMKISKLEVTEIVKPSPKRKMEPDTEKMDR---------TPEKDKISLSAPAKKIKLNR 1179
Query: 127 ENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKL-------------TPTSVLDYFGT-- 171
E G+ S SN K+ E ++ + + K+ + ++++DY T
Sbjct: 1180 ETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSS 1239
Query: 172 --GSVQRSNKKMVASKR---KELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFA 226
GS R +++ +KR K + + +++ E + +Q+ + + +EE
Sbjct: 1240 TGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDV 1299
Query: 227 RTLAMLDEEPKTKKARKDT------------EAGETFSSVQANLSKAEKHKYPHKVKTAQ 274
++ + K K+ + E +Q H+VK+++
Sbjct: 1300 KSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSK 1359
Query: 275 --VSDER-----KSYSPRKQSKYESSKESQQHSK-SSADKIGEVSSPKA---SSKLAIMK 323
S E+ + YS ++ E K S Q K S+ D++ E + K+ SSK A
Sbjct: 1360 NSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTS 1419
Query: 324 RKEESS-----------------YKEIEPVASKRKENAIKLKGETKTPKKTKSS------ 360
K +S+ Y E +SKR++ +L +P + K S
Sbjct: 1420 DKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKN 1479
Query: 361 --------------PAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENC 406
+KK + SP K + Y + E K++ ++
Sbjct: 1480 KPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHV 1539
Query: 407 LEG----------LIFVITGVLESIERDEAKSLIER----------YGGKVTGNVSKKTN 446
LE L++++ +E+++ I++ + +++ +++++T+
Sbjct: 1540 LEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETD 1599
Query: 447 YLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGK-KSKYEIAVETEMKKESKLER 505
D +S S+ + +E+ N+ + + K K + +++T + + R
Sbjct: 1600 EAAFEPDYNESDSES----NVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISR 1655
Query: 506 T---PQKNVQGKRKISPSKKESESKKSRPTS--KRDSLAKTIKKE 545
+V R SPS ++ S S +S +DS K KKE
Sbjct: 1656 NQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKE 1700
Score = 57.0 bits (136), Expect = 1e-07
Identities = 86/392 (21%), Positives = 156/392 (39%), Gaps = 66/392 (16%)
Query: 22 KKNEKTKSDEET----LKAKKGIKEIKVNS--SRKEDDFKQKQPSKKKRIIYDSDSESE- 74
K+ T+ ++E+ L + K + +S +R D + S K + D +++
Sbjct: 1384 KRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDY 1443
Query: 75 ETLQVKNAKKPPEKLPVSSKPGKISR-QDPVTYISETDEEDDFMCKKAASKSKENG---- 129
+T + ++K+ EK ++ + SR +D + E+ + KK SK++
Sbjct: 1444 DTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPS 1503
Query: 130 --RSTNSHLGTSNMKKNEENTKT-----------------KNKPLSPIKLT------PTS 164
R + H T + K+ E TK+ NK S KL T
Sbjct: 1504 RDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQ 1563
Query: 165 VLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEE 224
V TG + +S K ++D + DEA + + D+E + E+E
Sbjct: 1564 VEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEES 1623
Query: 225 FARTLAMLDEEPKTKKARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSP 284
+ ++ K K K E+ +T + VQ +S+ + H P VS R S+SP
Sbjct: 1624 SGN----ISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSP------SVSPSR-SHSP 1672
Query: 285 RKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENA 344
S +++ HS S++ + S K K+KE+ +K+ + K K++
Sbjct: 1673 -------SGSQTRSHSSSASSAESQDSKKKK-------KKKEKKKHKKHK----KHKKHK 1714
Query: 345 IKLKGETKTPKKTKSSPAKKESVSPEDSEKKR 376
E + K K KK+S +D EK++
Sbjct: 1715 KHAGTEVELEKSQKHKHKKKKSKKNKDKEKEK 1746
Score = 52.8 bits (125), Expect = 2e-06
Identities = 106/505 (20%), Positives = 195/505 (38%), Gaps = 37/505 (7%)
Query: 68 DSDSESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKE 127
D ++ + T K+ +K E P K K + E++ + + + KS+E
Sbjct: 872 DGHNQKDNT---KSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSRE 928
Query: 128 -NGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKR 186
G N + ++ T +++P+ +T SV + +R K A
Sbjct: 929 PTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSE-----KDKRERDKPKAKGD 983
Query: 187 KELSQNTDESGLNDEAI---AKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARK 243
K +N + E I AK Q D E ER + + +E PKT +
Sbjct: 984 KTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAK---EETPKTDNTKS 1040
Query: 244 DTEAGE----TFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQH 299
+ + + T + +A+ A++H+ VK +V +K YS +S+ ++KE +
Sbjct: 1041 SSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKV---KKDYSKDVKSEKLTTKEEK-- 1095
Query: 300 SKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKS 359
A K E + P +K KRK E + + +S K + +++ K K K
Sbjct: 1096 ----AKKPNEKNKP-LDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKM 1150
Query: 360 SPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLE 419
P ++ + +K + A + LNRE K +GS E + E L
Sbjct: 1151 EPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKL----ESTSS 1206
Query: 420 SIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQ--SKSDKAAALGTKIIDEDGLLN 477
+++++ K + R G+ S +Y G KS++ +I N
Sbjct: 1207 KVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYN 1266
Query: 478 LIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDS 537
T P + I V + E + +++V+ + IS K + K+ T K +
Sbjct: 1267 NDNTAPAEDVIIMIQVPQSKWDKDDFE-SEEEDVKSTQPISSVGKPASVIKNVST-KPSN 1324
Query: 538 LAKTIKKETDVFWKSLDFKEQVAEE 562
+ K +KE++ K F + V+ E
Sbjct: 1325 IVKYPEKESEPSEKIQKFTKDVSHE 1349
Score = 39.3 bits (90), Expect = 0.022
Identities = 107/513 (20%), Positives = 188/513 (36%), Gaps = 85/513 (16%)
Query: 18 SETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETL 77
S VK EK E K +K K++ + E + S +K D D E
Sbjct: 1323 SNIVKYPEKESEPSE--KIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLE-- 1378
Query: 78 QVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLG 137
K+ PEK S++P K S D + +E+ +F K+ S+S + R+++ H
Sbjct: 1379 -----KENPEKRKNSTQPEKESNLDRL------NEQGNF---KSLSQSSKEARTSDKHDS 1424
Query: 138 TSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESG 197
T N++ T ++K T +Y + S +R K + ++ S+N
Sbjct: 1425 T-RASSNKDFTPNRDKK------TDYDTREY--SSSKRRDEKNELTRRKDSPSRN----- 1470
Query: 198 LNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEA-GETFSSVQA 256
D A ++ + E+ +L ++ D + + + D +P KA DT+ E SV
Sbjct: 1471 -KDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDK 1529
Query: 257 NLSK-AEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKA 315
N K EKH + K S K + E+Q + +I + S+ K
Sbjct: 1530 NPCKDREKHVLEAR--------NNKESSGNKLLYILNPPETQVEKEQITGQIDK-STVKP 1580
Query: 316 SSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPEDSEKK 375
+L+ R +E + A + P +S SV E+S
Sbjct: 1581 KPQLSHSSRLSSDLTRETDEAAFE--------------PDYNESDSESNVSVKEEESSGN 1626
Query: 376 RTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGG 435
+ K L K + K E+ L+ V G+ + + + S+
Sbjct: 1627 IS--------------KDLKDKIVEKAKES-LDTAAVVQVGISRN-QSHSSPSVSPSRSH 1670
Query: 436 KVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVET 495
+G+ ++ + +S SK K K + KK K E
Sbjct: 1671 SPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHK---------KHKKHKKHKKHAGTEV 1721
Query: 496 EMKKESKLERTPQKNVQGKRKISPSKKESESKK 528
E++K K + +K+ + K K +KE + +K
Sbjct: 1722 ELEKSQKHKHKKKKSKKNKDK--EKEKEKDDQK 1752
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 61.2 bits (147), Expect = 5e-09
Identities = 123/645 (19%), Positives = 245/645 (37%), Gaps = 126/645 (19%)
Query: 14 KKLVSETVKKN--EKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDS 71
K + E VKK+ + KS++ T K +K K + N K+K+ +++K + D +S
Sbjct: 1103 KPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFES 1162
Query: 72 ESEE--TLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASK---SK 126
S + L+V KP K + K+ R T E+D A K ++
Sbjct: 1163 SSMKISKLEVTEIVKPSPKRKMEPDTEKMDR---------TPEKDKISLSAPAKKIKLNR 1213
Query: 127 ENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKL-------------TPTSVLDYFGT-- 171
E G+ S SN K+ E ++ + + K+ + ++++DY T
Sbjct: 1214 ETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSS 1273
Query: 172 --GSVQRSNKKMVASKR---KELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFA 226
GS R +++ +KR K + + +++ E + +Q+ + + +EE
Sbjct: 1274 TGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDV 1333
Query: 227 RTLAMLDEEPKTKKARKDT------------EAGETFSSVQANLSKAEKHKYPHKVKTAQ 274
++ + K K+ + E +Q H+VK+++
Sbjct: 1334 KSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSK 1393
Query: 275 --VSDER-----KSYSPRKQSKYESSKESQQHSK-SSADKIGEVSSPKA---SSKLAIMK 323
S E+ + YS ++ E K S Q K S+ D++ E + K+ SSK A
Sbjct: 1394 NSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTS 1453
Query: 324 RKEESS-----------------YKEIEPVASKRKENAIKLKGETKTPKKTKSS------ 360
K +S+ Y E +SKR++ +L +P + K S
Sbjct: 1454 DKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKN 1513
Query: 361 --------------PAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENC 406
+KK + SP K + Y + E K++ ++
Sbjct: 1514 KPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHV 1573
Query: 407 LEG----------LIFVITGVLESIERDEAKSLIER----------YGGKVTGNVSKKTN 446
LE L++++ +E+++ I++ + +++ +++++T+
Sbjct: 1574 LEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETD 1633
Query: 447 YLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGK-KSKYEIAVETEMKKESKLER 505
D +S S+ + +E+ N+ + + K K + +++T + + R
Sbjct: 1634 EAAFEPDYNESDSES----NVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISR 1689
Query: 506 T---PQKNVQGKRKISPSKKESESKKSRPTS--KRDSLAKTIKKE 545
+V R SPS ++ S S +S +DS K KKE
Sbjct: 1690 NQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKE 1734
Score = 57.0 bits (136), Expect = 1e-07
Identities = 86/392 (21%), Positives = 156/392 (39%), Gaps = 66/392 (16%)
Query: 22 KKNEKTKSDEET----LKAKKGIKEIKVNS--SRKEDDFKQKQPSKKKRIIYDSDSESE- 74
K+ T+ ++E+ L + K + +S +R D + S K + D +++
Sbjct: 1418 KRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDY 1477
Query: 75 ETLQVKNAKKPPEKLPVSSKPGKISR-QDPVTYISETDEEDDFMCKKAASKSKENG---- 129
+T + ++K+ EK ++ + SR +D + E+ + KK SK++
Sbjct: 1478 DTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPS 1537
Query: 130 --RSTNSHLGTSNMKKNEENTKT-----------------KNKPLSPIKLT------PTS 164
R + H T + K+ E TK+ NK S KL T
Sbjct: 1538 RDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQ 1597
Query: 165 VLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEE 224
V TG + +S K ++D + DEA + + D+E + E+E
Sbjct: 1598 VEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEES 1657
Query: 225 FARTLAMLDEEPKTKKARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSP 284
+ ++ K K K E+ +T + VQ +S+ + H P VS R S+SP
Sbjct: 1658 SGN----ISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSP------SVSPSR-SHSP 1706
Query: 285 RKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENA 344
S +++ HS S++ + S K K+KE+ +K+ + K K++
Sbjct: 1707 -------SGSQTRSHSSSASSAESQDSKKKK-------KKKEKKKHKKHK----KHKKHK 1748
Query: 345 IKLKGETKTPKKTKSSPAKKESVSPEDSEKKR 376
E + K K KK+S +D EK++
Sbjct: 1749 KHAGTEVELEKSQKHKHKKKKSKKNKDKEKEK 1780
Score = 52.8 bits (125), Expect = 2e-06
Identities = 106/505 (20%), Positives = 195/505 (38%), Gaps = 37/505 (7%)
Query: 68 DSDSESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKE 127
D ++ + T K+ +K E P K K + E++ + + + KS+E
Sbjct: 906 DGHNQKDNT---KSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSRE 962
Query: 128 -NGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKR 186
G N + ++ T +++P+ +T SV + +R K A
Sbjct: 963 PTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSE-----KDKRERDKPKAKGD 1017
Query: 187 KELSQNTDESGLNDEAI---AKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARK 243
K +N + E I AK Q D E ER + + +E PKT +
Sbjct: 1018 KTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAK---EETPKTDNTKS 1074
Query: 244 DTEAGE----TFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQH 299
+ + + T + +A+ A++H+ VK +V +K YS +S+ ++KE +
Sbjct: 1075 SSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKV---KKDYSKDVKSEKLTTKEEK-- 1129
Query: 300 SKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKS 359
A K E + P +K KRK E + + +S K + +++ K K K
Sbjct: 1130 ----AKKPNEKNKP-LDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKM 1184
Query: 360 SPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLE 419
P ++ + +K + A + LNRE K +GS E + E L
Sbjct: 1185 EPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKL----ESTSS 1240
Query: 420 SIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQ--SKSDKAAALGTKIIDEDGLLN 477
+++++ K + R G+ S +Y G KS++ +I N
Sbjct: 1241 KVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYN 1300
Query: 478 LIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDS 537
T P + I V + E + +++V+ + IS K + K+ T K +
Sbjct: 1301 NDNTAPAEDVIIMIQVPQSKWDKDDFE-SEEEDVKSTQPISSVGKPASVIKNVST-KPSN 1358
Query: 538 LAKTIKKETDVFWKSLDFKEQVAEE 562
+ K +KE++ K F + V+ E
Sbjct: 1359 IVKYPEKESEPSEKIQKFTKDVSHE 1383
Score = 39.3 bits (90), Expect = 0.022
Identities = 107/513 (20%), Positives = 188/513 (36%), Gaps = 85/513 (16%)
Query: 18 SETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETL 77
S VK EK E K +K K++ + E + S +K D D E
Sbjct: 1357 SNIVKYPEKESEPSE--KIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLE-- 1412
Query: 78 QVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLG 137
K+ PEK S++P K S D + +E+ +F K+ S+S + R+++ H
Sbjct: 1413 -----KENPEKRKNSTQPEKESNLDRL------NEQGNF---KSLSQSSKEARTSDKHDS 1458
Query: 138 TSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESG 197
T N++ T ++K T +Y + S +R K + ++ S+N
Sbjct: 1459 T-RASSNKDFTPNRDKK------TDYDTREY--SSSKRRDEKNELTRRKDSPSRN----- 1504
Query: 198 LNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEA-GETFSSVQA 256
D A ++ + E+ +L ++ D + + + D +P KA DT+ E SV
Sbjct: 1505 -KDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDK 1563
Query: 257 NLSK-AEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKA 315
N K EKH + K S K + E+Q + +I + S+ K
Sbjct: 1564 NPCKDREKHVLEAR--------NNKESSGNKLLYILNPPETQVEKEQITGQIDK-STVKP 1614
Query: 316 SSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPEDSEKK 375
+L+ R +E + A + P +S SV E+S
Sbjct: 1615 KPQLSHSSRLSSDLTRETDEAAFE--------------PDYNESDSESNVSVKEEESSGN 1660
Query: 376 RTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGG 435
+ K L K + K E+ L+ V G+ + + + S+
Sbjct: 1661 IS--------------KDLKDKIVEKAKES-LDTAAVVQVGISRN-QSHSSPSVSPSRSH 1704
Query: 436 KVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVET 495
+G+ ++ + +S SK K K + KK K E
Sbjct: 1705 SPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHK---------KHKKHKKHKKHAGTEV 1755
Query: 496 EMKKESKLERTPQKNVQGKRKISPSKKESESKK 528
E++K K + +K+ + K K +KE + +K
Sbjct: 1756 ELEKSQKHKHKKKKSKKNKDK--EKEKEKDDQK 1786
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 60.1 bits (144), Expect = 1e-08
Identities = 135/661 (20%), Positives = 259/661 (39%), Gaps = 98/661 (14%)
Query: 21 VKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDS-DSESEETLQV 79
++K ++ +++ E K K+ K + FK K+ K R++Y S +S EE LQ
Sbjct: 358 LRKEQRKENEPEAEKTHLFAKQEKAFYPKS---FKSKK-QKPSRVLYSSTESSDEEALQN 413
Query: 80 KNAKKPPEKLPVSSKPGKISRQDPVTY------------ISETDEEDDFMCKKAASKSKE 127
K +P +S ++++ V + ++ + K + KE
Sbjct: 414 KKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKE 473
Query: 128 NGRSTNSHLGT----SNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVA 183
N R TN + T S + E N + P L L + TG + + +
Sbjct: 474 NTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLH----LFHISTGKSPKHSCGLSE 529
Query: 184 SKRKELSQNTDESGLNDEAIAKQLQLD-------------EDAELERQLHEDEEFARTLA 230
+ L Q ++ L+ + LQ D E + ++ H+++ +
Sbjct: 530 KQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDF 589
Query: 231 MLDEEPKTKKARKDTEAGETFSSVQANLSKAEK-------HKYPHKVK-----TAQVSDE 278
L+ K+ KD + TF + L K +K HK HK + ++ E
Sbjct: 590 HLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGE 649
Query: 279 RKSYSPRKQSK-----YESSKESQQHSKSSADKIGEVSSPKASSKLAIMKR-------KE 326
++ Y + +K E +E + + +D+ ++ L + K+ K+
Sbjct: 650 KEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKD 709
Query: 327 ESSYKEIEPVASKR--KENAIKLKGETK---TPKKTKSSPAKKESVSPEDSEKKRTNYQA 381
+ S KE + V+ +R KE K+K E++ +K K ++E++ P D + + T+
Sbjct: 710 DKSTKE-KHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENI-PTDKDSEFTSLG- 766
Query: 382 YRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLI-ERYGGKVTGN 440
S + L KEI + + ES E+ E +S I E+ K+
Sbjct: 767 -MSAIEESIGLHLVEKEIDIEKQE---------KHIKESKEKPEKRSQIKEKDIEKMERK 816
Query: 441 VSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRT---MPGKKSKYEIAVETEM 497
+K + S + K D + + KI ++D L + G+KSK A++
Sbjct: 817 TFEKEKKIKHEHKSEKDKLDLSECV-DKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTD 875
Query: 498 KKESKLERTPQKNVQGK----RKISPSKKESESKKSRPTSKRDSLAKTIKKETDVFWKSL 553
+E E+ +K+ + K R ++ SK++ +K S +K+ K + + L
Sbjct: 876 DREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDREL 935
Query: 554 DFKEQVAEETS---------GDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGD 604
D KE+ ++ S + K ++ D + + L +K K LKT G++ D
Sbjct: 936 DKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKD 995
Query: 605 Q 605
+
Sbjct: 996 K 996
Score = 58.9 bits (141), Expect = 3e-08
Identities = 84/362 (23%), Positives = 142/362 (39%), Gaps = 18/362 (4%)
Query: 25 EKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKK 84
EK E+ +K K KE V+ KE +FK+++ KK E + L+ +
Sbjct: 698 EKKSKLEKNIKDDKSTKEKHVS---KERNFKEERDKIKKESEKSFREEKIKDLKEERENI 754
Query: 85 PPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKN 144
P +K + G + ++ + E D +K +SKE S + +++K
Sbjct: 755 PTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEK-RSQIKEKDIEKM 813
Query: 145 EENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIA 204
E T K K + + LD + K+ S E E N AI
Sbjct: 814 ERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLY-SHHTEKCHKEGEKSKNTAAIK 872
Query: 205 KQLQLDEDAELERQLHEDE--EFARTLAMLDEEPKTKKARKDTEAGETFSSVQANLSKAE 262
K ++ E + H+ E E R LA E+ +K K ++ E +S + +K +
Sbjct: 873 KTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSE-YSKSEKGKNKEK 931
Query: 263 KHKYPHKVKTAQ-----VSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASS 317
+ K K+ +++ + +K S + +K + S +K +
Sbjct: 932 DRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDG 991
Query: 318 KLAIMKRKEESSYKEIEPVASKRKENAI-KLKGETKTPKKTKSSPAKKESVSPEDSEKKR 376
K K K+ YKE + K + N++ KLK E PK KSSPA K++ EK+
Sbjct: 992 KEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKP-KSSPASKDT---RPKEKRL 1047
Query: 377 TN 378
N
Sbjct: 1048 VN 1049
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 60.1 bits (144), Expect = 1e-08
Identities = 135/661 (20%), Positives = 259/661 (39%), Gaps = 98/661 (14%)
Query: 21 VKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDS-DSESEETLQV 79
++K ++ +++ E K K+ K + FK K+ K R++Y S +S EE LQ
Sbjct: 381 LRKEQRKENEPEAEKTHLFAKQEKAFYPKS---FKSKK-QKPSRVLYSSTESSDEEALQN 436
Query: 80 KNAKKPPEKLPVSSKPGKISRQDPVTY------------ISETDEEDDFMCKKAASKSKE 127
K +P +S ++++ V + ++ + K + KE
Sbjct: 437 KKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKE 496
Query: 128 NGRSTNSHLGT----SNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVA 183
N R TN + T S + E N + P L L + TG + + +
Sbjct: 497 NTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLH----LFHISTGKSPKHSCGLSE 552
Query: 184 SKRKELSQNTDESGLNDEAIAKQLQLD-------------EDAELERQLHEDEEFARTLA 230
+ L Q ++ L+ + LQ D E + ++ H+++ +
Sbjct: 553 KQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDF 612
Query: 231 MLDEEPKTKKARKDTEAGETFSSVQANLSKAEK-------HKYPHKVK-----TAQVSDE 278
L+ K+ KD + TF + L K +K HK HK + ++ E
Sbjct: 613 HLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGE 672
Query: 279 RKSYSPRKQSK-----YESSKESQQHSKSSADKIGEVSSPKASSKLAIMKR-------KE 326
++ Y + +K E +E + + +D+ ++ L + K+ K+
Sbjct: 673 KEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKD 732
Query: 327 ESSYKEIEPVASKR--KENAIKLKGETK---TPKKTKSSPAKKESVSPEDSEKKRTNYQA 381
+ S KE + V+ +R KE K+K E++ +K K ++E++ P D + + T+
Sbjct: 733 DKSTKE-KHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENI-PTDKDSEFTSLG- 789
Query: 382 YRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLI-ERYGGKVTGN 440
S + L KEI + + ES E+ E +S I E+ K+
Sbjct: 790 -MSAIEESIGLHLVEKEIDIEKQE---------KHIKESKEKPEKRSQIKEKDIEKMERK 839
Query: 441 VSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRT---MPGKKSKYEIAVETEM 497
+K + S + K D + + KI ++D L + G+KSK A++
Sbjct: 840 TFEKEKKIKHEHKSEKDKLDLSECV-DKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTD 898
Query: 498 KKESKLERTPQKNVQGK----RKISPSKKESESKKSRPTSKRDSLAKTIKKETDVFWKSL 553
+E E+ +K+ + K R ++ SK++ +K S +K+ K + + L
Sbjct: 899 DREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDREL 958
Query: 554 DFKEQVAEETS---------GDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGD 604
D KE+ ++ S + K ++ D + + L +K K LKT G++ D
Sbjct: 959 DKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKD 1018
Query: 605 Q 605
+
Sbjct: 1019 K 1019
Score = 58.9 bits (141), Expect = 3e-08
Identities = 84/362 (23%), Positives = 142/362 (39%), Gaps = 18/362 (4%)
Query: 25 EKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKK 84
EK E+ +K K KE V+ KE +FK+++ KK E + L+ +
Sbjct: 721 EKKSKLEKNIKDDKSTKEKHVS---KERNFKEERDKIKKESEKSFREEKIKDLKEERENI 777
Query: 85 PPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKN 144
P +K + G + ++ + E D +K +SKE S + +++K
Sbjct: 778 PTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEK-RSQIKEKDIEKM 836
Query: 145 EENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIA 204
E T K K + + LD + K+ S E E N AI
Sbjct: 837 ERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLY-SHHTEKCHKEGEKSKNTAAIK 895
Query: 205 KQLQLDEDAELERQLHEDE--EFARTLAMLDEEPKTKKARKDTEAGETFSSVQANLSKAE 262
K ++ E + H+ E E R LA E+ +K K ++ E +S + +K +
Sbjct: 896 KTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSE-YSKSEKGKNKEK 954
Query: 263 KHKYPHKVKTAQ-----VSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASS 317
+ K K+ +++ + +K S + +K + S +K +
Sbjct: 955 DRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDG 1014
Query: 318 KLAIMKRKEESSYKEIEPVASKRKENAI-KLKGETKTPKKTKSSPAKKESVSPEDSEKKR 376
K K K+ YKE + K + N++ KLK E PK KSSPA K++ EK+
Sbjct: 1015 KEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKP-KSSPASKDT---RPKEKRL 1070
Query: 377 TN 378
N
Sbjct: 1071 VN 1072
>gi|31563534 replication factor C 2 isoform 1 [Homo sapiens]
Length = 354
Score = 60.1 bits (144), Expect = 1e-08
Identities = 58/239 (24%), Positives = 93/239 (38%), Gaps = 43/239 (17%)
Query: 584 LLWVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDKKHAKFGKFSGKDDGSSF 643
L WV+KY+P L I+G + S R +
Sbjct: 36 LPWVEKYRPVKLNEIVGNEDTVSRLEVFAR--------------------------EGNV 69
Query: 644 KAALLSGPPGVGKTTTA-----SLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSI 698
+++GPPG GKTT+ +L+ L + +ELNAS+ R ++ I
Sbjct: 70 PNIIIAGPPGTGKTTSILCLARALLGPALKDAMLELNASNDRGIDVVR---------NKI 120
Query: 699 KGFYSNGAASSVSTKHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHPK 758
K F +I+DE D M + + + K T+ + C +D+
Sbjct: 121 KMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEP 180
Query: 759 IRSLVHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNL 817
I+S C LR+ + QI +M++ KE + + II A D+RQ L+NL
Sbjct: 181 IQSR---CAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL 236
>gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]
Length = 1462
Score = 59.3 bits (142), Expect = 2e-08
Identities = 138/714 (19%), Positives = 266/714 (37%), Gaps = 115/714 (16%)
Query: 29 SDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKKPPEK 88
S ++ +AK+ ++ SS K++ K+ S S SE+TL K K
Sbjct: 748 SSDDGRRAKR-----RLRSSGKKNSVSHKKHS----------SSSEKTLHSKYVKGRDR- 791
Query: 89 LPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKNEENT 148
SS K S S E+ ++A + ++ G+ +H + E++
Sbjct: 792 ---SSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSK 848
Query: 149 KTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDE------------S 196
+ P S + ++ D+ GS + +K A + + N++ S
Sbjct: 849 SERECPHSKKRTLKENLSDHLRNGS--KPKRKNYAGSKWDSESNSERDVTKNSKNDSHPS 906
Query: 197 GLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGET---FSS 253
+E A E +E+ ++ + + ++ D+ K +++ T ++ S+
Sbjct: 907 SDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSN 966
Query: 254 VQANLSKAEKHKYPHK--VKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVS 311
+ N K +KHK+ K +K ++ +K K+++ K Q + GE
Sbjct: 967 SENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKAPKRKQAFHWQPPLEFGEEE 1026
Query: 312 SPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPED 371
+ K + KE+ + E + K+N +K + ++ + K ++V+
Sbjct: 1027 EEEIDDKQVTQESKEKKVSENNETI----KDNILKTEKSSE-----EDLSGKHDTVTVSS 1077
Query: 372 SEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIE 431
+ T + S P AL ++E +N V GV + ++ D+
Sbjct: 1078 DLDQFTKDDSKLSI----SPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDD------ 1127
Query: 432 RYGGKVTGNVSKKTNYLVMGRD-SGQSKSDKAAALGTKIIDEDGL-LNLIRTMPGKKSKY 489
N + D S +K ++ + LG +D + + L + M + +
Sbjct: 1128 --------------NMEICTPDRSSPAKVEETSPLGNARLDTPDINIVLKQDMATEHPQA 1173
Query: 490 EIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIKKETDVF 549
E+ + ESK V G+ S S + T K++ K+ D
Sbjct: 1174 EVVKQESSMSESK--------VLGEVGKQDSSSASLASAGESTGKKEVAEKSQINLIDKK 1225
Query: 550 WKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCAN 609
WK L + G+ A N A SS +V+ L V + KP L+ I + +
Sbjct: 1226 WKPL--------QGVGNLAAPNAAT-SSAVEVKVLTTVPEMKPQGLRIEIKSKNKVRPGS 1276
Query: 610 ---------KLLRWLRNWQKSSSEDKKHAKFGKFSGKDDGSSFKAALLSGPPGVGKTTTA 660
+L R RN + SS E +DD S ++ S K+
Sbjct: 1277 LFDEVRKTARLNRRPRNQESSSDEQTP--------SRDDDSQSRSPSRSRSKSETKSRHR 1328
Query: 661 SLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSNGAASSVSTKH 714
+ + + YS+ S +RS+SS + + S + + +G+YS G S S+ +
Sbjct: 1329 T---RSVSYSH-----SRSRSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSSY 1374
Score = 52.4 bits (124), Expect = 2e-06
Identities = 115/577 (19%), Positives = 223/577 (38%), Gaps = 77/577 (13%)
Query: 37 KKGIKEIKVN---SSRKEDDFKQKQPSKKKRIIYDSDSESEE--TLQVKNA---KKPPEK 88
KK KE KV +K+ ++ + +KK+RI+ SD ES + T ++K++ ++
Sbjct: 428 KKRRKEKKVKHKKKGKKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKSSCDRERSSRS 487
Query: 89 LPVSSKPGK---ISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKNE 145
+SS S+ D S T D K+ S+S G S + K+
Sbjct: 488 SSLSSHHSSKRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSR-----SRTASKSS 542
Query: 146 ENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAK 205
++++++K S K +G +R++K S RK SQ ++ + E +
Sbjct: 543 SHSRSRSKSRSSSK-----------SGHRKRASK----SPRKTASQLSENKPVKTEPLRA 587
Query: 206 QLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSVQANLSKAEKHK 265
+ +E+ ++ + E+ + + D P ++ ++ +Q +K H
Sbjct: 588 TMAQNENVVVQPVVAEN---IPVIPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKT-THL 643
Query: 266 YPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRK 325
P + T +++ +++ S K E + ES Q + S SSP++ S+ + R
Sbjct: 644 LPIQ-STYSLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSR-SSRSRS 701
Query: 326 EESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKE----SVSPEDSE--KKRTNY 379
SY +AS + K + S + S+S +D K+R
Sbjct: 702 YSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRS 761
Query: 380 QAYRSYLNRE-----GPKALGSKEIP-KGAENCL-------EGLIFVITGVLESIERDEA 426
++ ++ + K L SK + + +C+ L + S++ ++
Sbjct: 762 SGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQS 821
Query: 427 KSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKK 486
E+ G + + N R +SKS++ K ++ L + +R G K
Sbjct: 822 AQEKEK-----QGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRN--GSK 874
Query: 487 SKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESK------------KSRPTSK 534
K + ++ ES ER KN + S K+E E+ K +PT+K
Sbjct: 875 PKRKNYAGSKWDSESNSERDVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTK 934
Query: 535 RDSLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARN 571
S T + + WKS + ++ S + N
Sbjct: 935 --SSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSNSEN 969
Score = 37.0 bits (84), Expect = 0.11
Identities = 93/507 (18%), Positives = 189/507 (37%), Gaps = 58/507 (11%)
Query: 94 KPGKISRQDPVTY--ISETDEEDDFMCKKAASKSKENGRS--TNSHLGTSNMKKNEENTK 149
K K S D TY S+ E + +S+S+ RS + L +S+ + +++
Sbjct: 666 KREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSR 725
Query: 150 T--KNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQL 207
+ +NK + + +S + +R+ +++ +S +K + S +
Sbjct: 726 SHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSS-------- 777
Query: 208 QLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSVQANLSKAEKHKYP 267
E+ LH R + + ++ D + SSVQA S EK K
Sbjct: 778 --------EKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQG 829
Query: 268 HKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEE 327
+T ++ + K + + + ++ +D + S PK + E
Sbjct: 830 QMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSES 889
Query: 328 SSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLN 387
+S +++ +K +N + + + T S + VS + K T + + L
Sbjct: 890 NSERDV----TKNSKNDSHPSSDKEEGEATSDS---ESEVSEIHIKVKPTTKSSTNTSLP 942
Query: 388 REGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNY 447
+ SK+ +++ G + E + K ++G K N+ ++
Sbjct: 943 DDNGAWKSSKQRTSTSDS---------EGSCSNSENNRGKPQKHKHGSK--ENLKREHTK 991
Query: 448 LVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTP 507
V + G+ A + L G++ + EI + ++ +ESK ++
Sbjct: 992 KVKEKLKGKKDKKHKAPKRKQAFHWQPPLEF-----GEEEEEEID-DKQVTQESKEKKVS 1045
Query: 508 QKNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIKKETDVFWKSLDFKEQVA------E 561
+ N K I ++K SE S K D++ T+ + D F K D K ++ E
Sbjct: 1046 ENNETIKDNILKTEKSSEEDLS---GKHDTV--TVSSDLDQFTKD-DSKLSISPTALNTE 1099
Query: 562 ETSGDSKARNLADDSSENKVENLLWVD 588
E + ++S N VE++L D
Sbjct: 1100 ENVACLQNIQHVEESVPNGVEDVLQTD 1126
Score = 31.6 bits (70), Expect = 4.5
Identities = 34/169 (20%), Positives = 64/169 (37%), Gaps = 28/169 (16%)
Query: 252 SSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYE-----SSKESQQHSKSSADK 306
S ++ S+ KHK KVK ++ + S S ++K+ S+ S + K S D
Sbjct: 214 SELEHERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNKHAMNPKGHSERSDTNEKRSVDS 273
Query: 307 IGEVSSPKASSK---------------LAIMKRKEESSYKEIEPVASKRK----ENAIKL 347
+ P + + ++ + E ++ P+ S +K ++ K+
Sbjct: 274 SAKREKPVVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIVSDQKPSVSKSGRKI 333
Query: 348 KG----ETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPK 392
KG TP +++S + S E + Q R+Y G K
Sbjct: 334 KGRGTIRYHTPPRSRSCSESDDDDSSETPPHWKEEMQRLRAYRPPSGEK 382
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 58.9 bits (141), Expect = 3e-08
Identities = 80/368 (21%), Positives = 151/368 (41%), Gaps = 41/368 (11%)
Query: 28 KSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSK--KKRIIYDSDSESEETLQVK-NAKK 84
+SD+E++ ++ N+S+ K K KK SD+ESE++ K ++KK
Sbjct: 253 QSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKK 312
Query: 85 PPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKN 144
+ + K + + T D +D+ +K K K+ +KK+
Sbjct: 313 VKKNVKKDDKKKDVKKDTESTDAESGDSKDE---RKDTKKDKKK------------LKKD 357
Query: 145 EENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVAS--KRKELSQNTDESGLNDEA 202
++ TK P S T T D + R+ KK + K+K+ + T + E
Sbjct: 358 DKKKDTKKYPES----TDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESEL 413
Query: 203 IAKQLQLDEDAELE-------RQLHEDEEFARTLAMLDEEPK--TKKARKDTEAGETFSS 253
+K+ Q DE + + + + DEE D EPK +KK +KD + G+ S
Sbjct: 414 ESKESQKDEKKDKKDSKTDNKKSVKNDEESTDA----DSEPKGDSKKGKKDEKKGKKDSK 469
Query: 254 VQANLSKAEKHKYPHKVKT-AQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSS 312
A+K+ ++++ ++ ++K +K SK + K++++ ++S+ + E S
Sbjct: 470 KDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSK 529
Query: 313 PKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETK---TPKKTKSSPAKKESVSP 369
+ I ES +P A K+ + + +K K + K++
Sbjct: 530 TGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFN 589
Query: 370 EDSEKKRT 377
E EK T
Sbjct: 590 EKGEKAST 597
Score = 57.4 bits (137), Expect = 8e-08
Identities = 124/620 (20%), Positives = 224/620 (36%), Gaps = 104/620 (16%)
Query: 20 TVKKNEKTKSDEETLKAKKGIKEI--KV-------NSSRKEDDFKQKQPSK---KKRIIY 67
TV +++K K +E A K I+ K+ ++R++ F+ SK KK
Sbjct: 57 TVTRHDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYK 116
Query: 68 DSDSESEETLQVKNAKK--------PPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCK 119
S E T K++KK P K V K + + D S + E K
Sbjct: 117 KSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQS---K 173
Query: 120 KAASKSKENGRSTNSHLGTSNM----KKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQ 175
K+ S S+ N S NS + N KK+ +N+K N K P
Sbjct: 174 KSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNP------------- 220
Query: 176 RSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEE 235
+ + K + +S+ E+ LN + + Q D+++
Sbjct: 221 KKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESI--------------------- 259
Query: 236 PKTKKARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKE 295
F + N S+ Y K D +K+ ++ E SK+
Sbjct: 260 --------------NFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKD 305
Query: 296 SQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPK 355
+++ SK + K K +K+ ES+ E +RK+ K K K
Sbjct: 306 AKKDSKKVKKNV------KKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDK 359
Query: 356 K--TKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFV 413
K TK P ++ S + + + + ++ N + K +E+ LE
Sbjct: 360 KKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELES---- 415
Query: 414 ITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDED 473
+ ++DE K ++ K S K + DS K K +D
Sbjct: 416 -----KESQKDEKK---DKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKD 467
Query: 474 GLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTS 533
+ KK + A TEM+ + +L++ + + + K KK++ +
Sbjct: 468 S-----KKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDA 522
Query: 534 KRDSLAKT-IKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSEN-KVENLLWVDKYK 591
+ D +KT K T + K D + + + G K + +D +S N K+E L ++
Sbjct: 523 EFDESSKTGFKTSTKI--KGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFR 580
Query: 592 PTSLKTIIGQQGDQSCANKL 611
+S KT ++G+++ ++
Sbjct: 581 MSSKKTTFNEKGEKASTGRV 600
Score = 55.1 bits (131), Expect = 4e-07
Identities = 87/410 (21%), Positives = 150/410 (36%), Gaps = 58/410 (14%)
Query: 11 PSGKKLVSETVKKNEKT-----KSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRI 65
P K++V E K+ + KS E ++KK + N + K S+K +
Sbjct: 142 PESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDK- 200
Query: 66 IYDSDSESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYI-SETDEEDDFMCKKAASK 124
DS + + + + K P+K SK + DP++ I SE DF+
Sbjct: 201 -KDSKNSKKTNTEFLHTKNNPKKDLKRSK----TSNDPISEICSENSLNVDFLMLV---- 251
Query: 125 SKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVAS 184
G+S + + +N +KN L K T S S A
Sbjct: 252 ----GQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAK 307
Query: 185 K-RKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARK 243
K K++ +N + + K+ DAE E ++ + L ++ K K +K
Sbjct: 308 KDSKKVKKNVKKDDKKKDV--KKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKK 365
Query: 244 -----DTEAGETFSSVQ--ANLSKAEKH--------KYPHKVKTAQVSDERKSYSPRKQS 288
DTE+G+ + NL KA K+ K + + ++S K+
Sbjct: 366 YPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKD 425
Query: 289 KYESSKESQQHSKSSADKIGEVSSPKASSKLAIM------------------KRKEESSY 330
K +S ++++ K+ + S PK SK K+ ES+
Sbjct: 426 KKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTE 485
Query: 331 KEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQ 380
E + K K+++ + KG K K K + ES E E +T ++
Sbjct: 486 MESDLELKKDKKHSKEKKGSKKDIK--KDARKDTESTDAEFDESSKTGFK 533
Score = 45.8 bits (107), Expect = 2e-04
Identities = 82/386 (21%), Positives = 152/386 (39%), Gaps = 56/386 (14%)
Query: 286 KQSKYESSKESQQHS---KSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKE 342
K+++Y+ SK+ + + K S K G ++ S ++ K K ++ + +S E
Sbjct: 111 KKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENE 170
Query: 343 NAIKLKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLN-REGPKALGSKEIPK 401
+ K K ++T ++++S ++ S +D + + + + +L+ + PK K++ +
Sbjct: 171 QSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPK----KDLKR 226
Query: 402 G-------AENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDS 454
+E C E + V +L DE+ N+ R+
Sbjct: 227 SKTSNDPISEICSENSLNVDFLMLVGQSDDES------------------INFDAWLRNY 268
Query: 455 GQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGK 514
Q+ S + TK +D N ++ + + A + K + +++ +K K
Sbjct: 269 SQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKK 328
Query: 515 RKISPSKKESESKKSRPTSKRD--SLAK-TIKKETDVFWKSLDFKEQVAEETSGDSKARN 571
S + +SK R +K+D L K KK+T + +S D + A++ DS RN
Sbjct: 329 DTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDS--RN 386
Query: 572 LADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDKKHAKF 631
L S D K + K + +K QK +DKK +K
Sbjct: 387 LKKASKN---------DDKKKDAKKITFSTDSESELESK------ESQKDEKKDKKDSKT 431
Query: 632 -GKFSGKDDGSSFKAALLSGPPGVGK 656
K S K+D S A S P G K
Sbjct: 432 DNKKSVKNDEESTDAD--SEPKGDSK 455
Score = 39.3 bits (90), Expect = 0.022
Identities = 49/195 (25%), Positives = 79/195 (40%), Gaps = 14/195 (7%)
Query: 457 SKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRK 516
SK+ A K DE G L + K Y E++ E E+T ++N K
Sbjct: 106 SKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVE---EKTKRQNEADKTP 162
Query: 517 ISPSKKESESKKSRPTSK---RDSLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLA 573
+ S + +SKKS+ +S+ +KT+ K K D K T N
Sbjct: 163 LKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKK-DSKNSKKTNTEFLHTKNNPK 221
Query: 574 DDSSENKVENLLWVDKYKPTSLKT----IIGQQGDQSCANKLLRWLRNWQKSSSEDKKHA 629
D +K N + SL ++GQ D+S WLRN+ +++S++
Sbjct: 222 KDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESI--NFDAWLRNYSQNNSKNYS-L 278
Query: 630 KFGKFSGKDDGSSFK 644
K+ K++ KD + K
Sbjct: 279 KYTKYTKKDTKKNAK 293
Score = 33.1 bits (74), Expect = 1.6
Identities = 28/92 (30%), Positives = 42/92 (45%), Gaps = 7/92 (7%)
Query: 14 KKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRK-------EDDFKQKQPSKKKRII 66
K S ++ + + K D++ K KKG K+ +RK E D K K I
Sbjct: 479 KNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKI 538
Query: 67 YDSDSESEETLQVKNAKKPPEKLPVSSKPGKI 98
SD+ESEE+L AKK ++ +S K+
Sbjct: 539 KGSDTESEESLYKPGAKKKIDESDGTSANSKM 570
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 58.5 bits (140), Expect = 3e-08
Identities = 139/670 (20%), Positives = 252/670 (37%), Gaps = 116/670 (17%)
Query: 40 IKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQV-----KNAKKPPEK--LPVS 92
+K KV + + + + +KKK DS+ SEE +V K A P ++ LP
Sbjct: 58 LKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPG 117
Query: 93 SKPGKISRQDPVTYISETDEEDDFMCK----------KAASKSKENGRSTNSHLGTSNMK 142
K S S+ D+E+D + KAA + +S++S +S+
Sbjct: 118 KAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSED 177
Query: 143 KNEENTKTKNKPLSPIKLT-----PTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESG 197
+ +N K K P++ T P G S+ +S + S+ +
Sbjct: 178 EPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAA 237
Query: 198 LNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSVQAN 257
+ + K+ + + + + + DEE + KK K+ +SSV
Sbjct: 238 TPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPG--PYSSVPPP 295
Query: 258 LSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSP---- 313
+ P K+ +K+ KQ ESS++S S SS+++ E P
Sbjct: 296 SA-------PPPKKSLGTQPPKKAV--EKQQPVESSEDSSDESDSSSEE--EKKPPTKAV 344
Query: 314 --KASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKT----PKKTKSSPAKKESV 367
KA++K K+ ESS + +S+ E K G TK P T SPA K +
Sbjct: 345 VSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAA 404
Query: 368 SPE-------------------DSEKKRTNYQAYRSYLNREGPKA-------LGSKEIPK 401
+P+ + E + + + + PKA L +K+ P+
Sbjct: 405 APKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQ 464
Query: 402 GAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVS-----------KKTNYLVM 450
G+ + + E E +KS +++ KV G + +++
Sbjct: 465 GSRDSSSD---SDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSS 521
Query: 451 GRDSGQSKSDKAAALGT--KIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQ 508
DS + + +K G+ + + + GK +K E E KK + + +
Sbjct: 522 SDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVV--VSK 579
Query: 509 KNVQGKRKISPSKKESESKKSRPTSKR--DSLAKTIKKETDVFWKSLDFKEQVAEETSGD 566
KRK + + KE+E+ +++ + ++ K K E S F+ EE D
Sbjct: 580 SGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRA---SSPFRRVREEEIEVD 636
Query: 567 SKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDK 626
S+ +AD+S + K + G G++ AN++L++ + KS +K
Sbjct: 637 SR---VADNSFDAK---------------RGAAGDWGER--ANQVLKFTKG--KSFRHEK 674
Query: 627 KHAKFGKFSG 636
K G + G
Sbjct: 675 TKKKRGSYRG 684
Score = 46.6 bits (109), Expect = 1e-04
Identities = 92/401 (22%), Positives = 150/401 (37%), Gaps = 57/401 (14%)
Query: 23 KNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNA 82
KN+K K T+KA+ ++ K + K S SD EE
Sbjct: 181 KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK 240
Query: 83 KKPPEKLPVSSKPGKI----SRQDPVTYISETDEEDDFMCKKAASKSKENGRST------ 132
K P+K V+ P K +R+ + S +DEE++ +K K+K S+
Sbjct: 241 KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEE---QKKPMKNKPGPYSSVPPPSA 297
Query: 133 ---NSHLGTSNMKK----------NEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNK 179
LGT KK +E+++ + K PT + + + K
Sbjct: 298 PPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAV------VSKATTK 351
Query: 180 KMVASKRKELSQNT--DESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAML----- 232
A K E S ++ +S +DEA +K +++ + + + A
Sbjct: 352 PPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVG 411
Query: 233 -DEEPKTKKARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERK-----SYSPRK 286
++ T+KA + E+ SS + K P A +S K S
Sbjct: 412 GGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSS 471
Query: 287 QSKYESSKESQQHSKSSA--DKIGEVSSPKASSKLAIMKR-KEESSYKEIEPVASKRKEN 343
S SS+E ++ + SA K +V+ A SK A K+ K ESS +S+ +E
Sbjct: 472 DSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE 531
Query: 344 AIKLKGETK--TPKKTKSS-------PAKKESVSPEDSEKK 375
+K KG + PK +S A K S E+ +KK
Sbjct: 532 KLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKK 572
Score = 33.9 bits (76), Expect = 0.91
Identities = 27/95 (28%), Positives = 39/95 (41%), Gaps = 9/95 (9%)
Query: 1051 SKLDPKVKAAFTRAYNKEAHLTPYSLQAIKASRHSTSPSLDSEYNEELNEDDSQSDEKDQ 1110
S + K K K SL A +A + S S DS DS S E+++
Sbjct: 432 SSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDS---------DSSSSEEEE 482
Query: 1111 DAIETDAMIKKKTKSSKPSKPEKDKEPRKGKGKSS 1145
+ A+ KK K + + P K +KGK +SS
Sbjct: 483 EKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESS 517
>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 58.5 bits (140), Expect = 3e-08
Identities = 128/637 (20%), Positives = 248/637 (38%), Gaps = 94/637 (14%)
Query: 14 KKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSES 73
+K+ E KK EK + +++ + K KE K + D P +R +DSD E
Sbjct: 241 EKMEREKQKKLEKERMEQQRSQLSK--KEKKATEDAEGGD----GPRLPQRSKFDSDEEE 294
Query: 74 EETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTN 133
E+T V+ A S P + DP ++E ++E M ++ T+
Sbjct: 295 EDTENVEAASSGKVTRSPSPVPQE-EHSDP--EMTEEEKEYQMMLLTKMLLTEILLDVTD 351
Query: 134 SHLGTSNMKKNEENTKTKNKPLSP----IKLTPTSVLDYFGTGSVQRSNKKMVASKRKEL 189
+ + + TK K L+ LT L +G+G S+ +
Sbjct: 352 EEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGD----------SEDERS 401
Query: 190 SQNTDESGLNDEAIAKQLQLDEDA----ELERQLHEDEEFARTLAMLDEEPKTKKARKDT 245
+ ++ S +DE + +++ ++A E E+QL D++ EE K + R
Sbjct: 402 DRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQM--------EEEKQQTERVTK 453
Query: 246 EAGETFSSVQANLSKAEKHKYPHKV---------KTAQVSDERKSYSPRKQSKYESSKES 296
E E Q +LS E + V +T V + +K + +++ S S
Sbjct: 454 EMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSS 513
Query: 297 QQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKK 356
S SS + SS +SS + +S + P KRK+ + + T ++
Sbjct: 514 SSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSP---KRKKRHSRSRSPTIKARR 570
Query: 357 TKS-SPAKKESVSPEDSEKK-RTNYQAYRSYLNREGPKALG-SKEIPKGAENCLEGLIFV 413
++S S +++ + + K R ++ R+ + RE + S+E + +
Sbjct: 571 SRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRR--- 627
Query: 414 ITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDED 473
S RD K I+ G ++GN K G++K + ++ ID+D
Sbjct: 628 TNRASRSRSRDRRK--IDDQRGNLSGNSHK---------HKGEAKEQERKKERSRSIDKD 676
Query: 474 GLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTS 533
+ K + E E K + ++ +K+ + + K++ ES+ R S
Sbjct: 677 ------------RKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESE--RTFS 722
Query: 534 KRDSLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPT 593
+ S++ I + D ++ + T+ DSK + +D S + E+ P
Sbjct: 723 RSGSISVKIIRH--------DSRQDSKKSTTKDSKKHSGSDSSGRSSSES--------PG 766
Query: 594 SLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDKKHAK 630
S K ++ S + + + R+ +K+S + K ++
Sbjct: 767 SSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSR 803
Score = 44.3 bits (103), Expect = 7e-04
Identities = 67/346 (19%), Positives = 135/346 (39%), Gaps = 20/346 (5%)
Query: 9 VIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYD 68
V+ K+ +ET E K +E K + + S + S Y
Sbjct: 478 VVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYS 537
Query: 69 SDSESEETLQVKNAKKPPEKLPVSSKPG-KISRQDPVTYISETDEEDDFMCKKAASKSKE 127
S S S T ++ K ++ S P K R +Y E + +A K ++
Sbjct: 538 SSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESN----RARVKIRD 593
Query: 128 NGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRK 187
RS + + ++N ++ + + S + T+ R+++ +RK
Sbjct: 594 RRRSNRNSIERER-RRNRSPSRERRRSRSRSRDRRTN-----------RASRSRSRDRRK 641
Query: 188 ELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEA 247
Q + SG + + + + + E R + +D + + E+ K K+ +K E
Sbjct: 642 IDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRK-KKDKEREREQDKRKEKQKREEK 700
Query: 248 GETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKI 307
FSS L + + + ++ +S + + R+ SK ++K+S++HS S +
Sbjct: 701 DFKFSSQDDRLKRKRESERTFS-RSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGR 759
Query: 308 GEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKT 353
SP SSK K+ + S + +E K+ + K K ++++
Sbjct: 760 SSSESP-GSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804
>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 58.5 bits (140), Expect = 3e-08
Identities = 128/637 (20%), Positives = 248/637 (38%), Gaps = 94/637 (14%)
Query: 14 KKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSES 73
+K+ E KK EK + +++ + K KE K + D P +R +DSD E
Sbjct: 241 EKMEREKQKKLEKERMEQQRSQLSK--KEKKATEDAEGGD----GPRLPQRSKFDSDEEE 294
Query: 74 EETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTN 133
E+T V+ A S P + DP ++E ++E M ++ T+
Sbjct: 295 EDTENVEAASSGKVTRSPSPVPQE-EHSDP--EMTEEEKEYQMMLLTKMLLTEILLDVTD 351
Query: 134 SHLGTSNMKKNEENTKTKNKPLSP----IKLTPTSVLDYFGTGSVQRSNKKMVASKRKEL 189
+ + + TK K L+ LT L +G+G S+ +
Sbjct: 352 EEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGD----------SEDERS 401
Query: 190 SQNTDESGLNDEAIAKQLQLDEDA----ELERQLHEDEEFARTLAMLDEEPKTKKARKDT 245
+ ++ S +DE + +++ ++A E E+QL D++ EE K + R
Sbjct: 402 DRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQM--------EEEKQQTERVTK 453
Query: 246 EAGETFSSVQANLSKAEKHKYPHKV---------KTAQVSDERKSYSPRKQSKYESSKES 296
E E Q +LS E + V +T V + +K + +++ S S
Sbjct: 454 EMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSS 513
Query: 297 QQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKK 356
S SS + SS +SS + +S + P KRK+ + + T ++
Sbjct: 514 SSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSP---KRKKRHSRSRSPTIKARR 570
Query: 357 TKS-SPAKKESVSPEDSEKK-RTNYQAYRSYLNREGPKALG-SKEIPKGAENCLEGLIFV 413
++S S +++ + + K R ++ R+ + RE + S+E + +
Sbjct: 571 SRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRR--- 627
Query: 414 ITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDED 473
S RD K I+ G ++GN K G++K + ++ ID+D
Sbjct: 628 TNRASRSRSRDRRK--IDDQRGNLSGNSHK---------HKGEAKEQERKKERSRSIDKD 676
Query: 474 GLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTS 533
+ K + E E K + ++ +K+ + + K++ ES+ R S
Sbjct: 677 ------------RKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESE--RTFS 722
Query: 534 KRDSLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPT 593
+ S++ I + D ++ + T+ DSK + +D S + E+ P
Sbjct: 723 RSGSISVKIIRH--------DSRQDSKKSTTKDSKKHSGSDSSGRSSSES--------PG 766
Query: 594 SLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDKKHAK 630
S K ++ S + + + R+ +K+S + K ++
Sbjct: 767 SSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSR 803
Score = 44.3 bits (103), Expect = 7e-04
Identities = 67/346 (19%), Positives = 135/346 (39%), Gaps = 20/346 (5%)
Query: 9 VIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYD 68
V+ K+ +ET E K +E K + + S + S Y
Sbjct: 478 VVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYS 537
Query: 69 SDSESEETLQVKNAKKPPEKLPVSSKPG-KISRQDPVTYISETDEEDDFMCKKAASKSKE 127
S S S T ++ K ++ S P K R +Y E + +A K ++
Sbjct: 538 SSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESN----RARVKIRD 593
Query: 128 NGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRK 187
RS + + ++N ++ + + S + T+ R+++ +RK
Sbjct: 594 RRRSNRNSIERER-RRNRSPSRERRRSRSRSRDRRTN-----------RASRSRSRDRRK 641
Query: 188 ELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEA 247
Q + SG + + + + + E R + +D + + E+ K K+ +K E
Sbjct: 642 IDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRK-KKDKEREREQDKRKEKQKREEK 700
Query: 248 GETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKI 307
FSS L + + + ++ +S + + R+ SK ++K+S++HS S +
Sbjct: 701 DFKFSSQDDRLKRKRESERTFS-RSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGR 759
Query: 308 GEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKT 353
SP SSK K+ + S + +E K+ + K K ++++
Sbjct: 760 SSSESP-GSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 57.8 bits (138), Expect = 6e-08
Identities = 86/414 (20%), Positives = 168/414 (40%), Gaps = 44/414 (10%)
Query: 14 KKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSES 73
KK +KK EK K +E + KK IK+ + +KE K++ P K+ + + +
Sbjct: 662 KKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKE--VKKETPPKEVKKEVKKEEKK 719
Query: 74 EETLQVKNAKKPPEKLPVSSKPGKI---SRQDPVTYISETDEEDDFMCKK--AASKSKEN 128
E + K KK +KLP +K + P + ++++ + K AA K KE
Sbjct: 720 EVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEK 779
Query: 129 GRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKE 188
G+ +K ++ K + + T+ G K + ++R
Sbjct: 780 GK----------IKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSL 829
Query: 189 LSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLD------EEPKTKKAR 242
+S D + +E A+++ + +D + + +L EDEE + ++ E TK
Sbjct: 830 MSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPA 889
Query: 243 KDTEAGETFSSVQA-------NLSKAEK------HKYPHKVKTAQVSDERKSYSPRKQSK 289
+ + G T + + L EK K+ + + S E Y + +++
Sbjct: 890 ESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETE 949
Query: 290 --YESSKESQQHSKSSADK---IGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENA 344
E ++ ++H SA K + S KA + I +++E S + A + + A
Sbjct: 950 EAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRE--SVASGDDRAEEDMDEA 1007
Query: 345 IKLKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKE 398
I+ KGE + ++ K E E+ E ++ + Y + + +A G++E
Sbjct: 1008 IE-KGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEE 1060
Score = 45.8 bits (107), Expect = 2e-04
Identities = 73/331 (22%), Positives = 119/331 (35%), Gaps = 48/331 (14%)
Query: 68 DSDSESEETLQVKNAKKPPEKLPVSSKPGKISRQDPV-TYISETDEEDDFMCKKAASKSK 126
+S+ S ET K + P KI+R TY ET + +C A KS
Sbjct: 2019 ESEGYSYET-STKTTRTPDTSTYCYETAEKITRTPQASTYSYETSD----LCYTAEKKSP 2073
Query: 127 ENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKR 186
R S+ + T+ LSP + P + + + S K + S
Sbjct: 2074 SEARQDVDLCLVSSCEYKHPKTE-----LSPSFINPNPLEWFASEEPTEESEKPLTQSGG 2128
Query: 187 -------KELSQNTDESGLNDEAIAKQLQLDEDAELERQL-----------HEDE----- 223
K+ + DE+ + + Q D D E + EDE
Sbjct: 2129 APPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIP 2188
Query: 224 -EFARTLAMLDEEPKTKKARKDTEAGETFS-------SVQANLSKAEKHKYPHKVKTAQV 275
+ T +D P + R + S +++ NL KA K K KT +
Sbjct: 2189 TDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKP 2248
Query: 276 SDERKSYSPRKQSKYESSKESQQHS----KSSADKIGEVSSPKASSKLAIMKRKEESSYK 331
+ KS SP K+S +S + K S+DK+ V+SPK K ++ K + ++
Sbjct: 2249 GTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPK--KKESVEKAAKPTTTP 2306
Query: 332 EIEPVASKRKENAIKLKGETKTPKKTKSSPA 362
E++ + K+ K K K++ A
Sbjct: 2307 EVKAARGEEKDKETKNAANASASKSAKTATA 2337
Score = 44.7 bits (104), Expect = 5e-04
Identities = 79/406 (19%), Positives = 146/406 (35%), Gaps = 28/406 (6%)
Query: 186 RKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDT 245
++ L+ D +G + KQ +L + A+ L + A+ L +K RK++
Sbjct: 512 KQPLATQKDLTGQVPTPVVKQTKLKQRADSRESL---KPAAKPLP-------SKSVRKES 561
Query: 246 EAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSS-A 304
+ + ++ K K + KV + + P K SKE K+ A
Sbjct: 562 KEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVA 621
Query: 305 DKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKK 364
+K PKA+ + + K+E+ K + K K K E KTP K + P K+
Sbjct: 622 EKQATDVKPKAAKEKTV---KKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKE 678
Query: 365 ESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERD 424
E E K+ + + + +E P KE+ K + ++ ++ + +D
Sbjct: 679 EVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKD 738
Query: 425 EAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPG 484
KS K + K + + K D AA K E G + +I+
Sbjct: 739 AKKSSTPLSEAKKPAALKPK-----VPKKEESVKKDSVAAGKPK---EKGKIKVIKKEGK 790
Query: 485 KKSKYEIAVETEMKKESKLERT------PQKNVQGKRKISPSKKESESKKSRPTSKRDSL 538
AV T + + P K ++ +R + S ++ ++ +
Sbjct: 791 AAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDV 850
Query: 539 AKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENL 584
K IK + ++ KE E K R + +E+ E +
Sbjct: 851 TKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGI 896
Score = 37.0 bits (84), Expect = 0.11
Identities = 99/515 (19%), Positives = 187/515 (36%), Gaps = 64/515 (12%)
Query: 11 PSGKKLVSETVKKNEKTKSDEET------------------LKAKKGIK-EIKVNSSRKE 51
P+ K L S++V+K K ++ E T +K K IK E K + + KE
Sbjct: 547 PAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKE 606
Query: 52 DDFKQKQPSKKKRIIYDSDSES-------EETLQVKNAKKPPEKLPVSSKPGK-ISRQDP 103
K+ +PS K + + + E+T++ + KP +K KP K +++++
Sbjct: 607 VPSKE-EPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKED 665
Query: 104 VTYISETDEEDDFMCKKAASK----------SKENGRSTNSHLGTSNMKKNE--ENTKTK 151
T I + ++ KK K KE + T +KK E E K +
Sbjct: 666 KTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEE 725
Query: 152 NKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDE 211
+P IK P S S K A+ + ++ + + + A K + +
Sbjct: 726 KEPKKEIKKLPKDA----KKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGK 781
Query: 212 DAELERQLHEDEEFARTLAMLDEEPKTKKA--------RKDTEAGETFSSVQANLSK-AE 262
++++ E A + A K+ EA + S +L+K E
Sbjct: 782 IKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFE 841
Query: 263 KHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIM 322
+ K T + + + ++ K E+ K G SP
Sbjct: 842 ELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEG 901
Query: 323 KRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPEDSEKKR------ 376
+ + E + +E+EPV + ++ K + E +++ + +E E++E+
Sbjct: 902 EGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEH 961
Query: 377 --TNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYG 434
+ + + E KA I + E+ G + E+IE+ EA+ E
Sbjct: 962 VCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEAD 1021
Query: 435 GKVTGNVSKKTNY---LVMGRDSGQSKSDKAAALG 466
+ +++ Y + D + DKAA G
Sbjct: 1022 EEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAG 1056
>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 56.2 bits (134), Expect = 2e-07
Identities = 65/338 (19%), Positives = 130/338 (38%), Gaps = 17/338 (5%)
Query: 3 IRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKK 62
I + +G+K + ++ + K D + +K +E++ + E+ ++ S +
Sbjct: 1189 IEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSE 1248
Query: 63 KRIIYDSDSESEETLQVKN--AKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKK 120
+DS + + K ++ EK VS + + + E +EE+D +
Sbjct: 1249 VPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAET 1308
Query: 121 AASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKK 180
A + + + HL ++ K+ EE ++ P V + F ++Q+S +K
Sbjct: 1309 AQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEP------GVQESFLDANMQKSREK 1362
Query: 181 MVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKK 240
+ + EL ++ + +++Q+ ED + E H EE L L EE +
Sbjct: 1363 IKDKEETELDSEEEQPSHDTSVVSEQMAGSED-DHEEDSHTKEE----LIELKEEEEIPH 1417
Query: 241 ARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHS 300
+ D E + S+ S + Y +T +SY+ + S E H+
Sbjct: 1418 SELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVE-DCHA 1476
Query: 301 KSSADKIGEVSSPKASSKLAIMKRKE---ESSYKEIEP 335
I V S + S ++ ES Y +I P
Sbjct: 1477 SEHNSPISSVQSHPSQSVRSVSSPNVPALESGYTQISP 1514
Score = 33.1 bits (74), Expect = 1.6
Identities = 74/383 (19%), Positives = 140/383 (36%), Gaps = 57/383 (14%)
Query: 206 QLQLDEDAELERQLHEDEEFARTLA--MLDEEPKTKKARKDTEAGETFSSVQAN------ 257
++ +E+ E E +L E F R + +L + +K+ KD E E
Sbjct: 1066 EIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPV 1125
Query: 258 --LSKAEKHKYPHKVKTAQVSDERKSYSPRKQSK-------------YESSKESQQHSKS 302
L K + P + T+ ++K + K K ++ S+E S
Sbjct: 1126 SLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQ 1185
Query: 303 SADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPA 362
+ VS PKA K I + +E KE P+ +RKE +++ E + ++ + A
Sbjct: 1186 ACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEE-EMQAEAEEAEEGEEEDA 1244
Query: 363 KKESV---SPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLE 419
V SP DS + + E K S+E + E E LE
Sbjct: 1245 ASSEVPAASPADSSNS-PETETKEPEVEEEEEKPRVSEEQRQSEEEQQE---------LE 1294
Query: 420 SIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLI 479
E +E + ++ ++ D G +S K L + ED +
Sbjct: 1295 EPEPEEEED--------AAAETAQNDDHDADDEDDGHLESTKKKELEEQPTRED-----V 1341
Query: 480 RTMPGKKSKY------EIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTS 533
+ PG + + + + + K+E++L+ ++ +S SE +
Sbjct: 1342 KEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSH 1401
Query: 534 KRDSLAKTIKKETDVFWKSLDFK 556
++ L + +K+E ++ LD +
Sbjct: 1402 TKEELIE-LKEEEEIPHSELDLE 1423
>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 56.2 bits (134), Expect = 2e-07
Identities = 65/338 (19%), Positives = 130/338 (38%), Gaps = 17/338 (5%)
Query: 3 IRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKK 62
I + +G+K + ++ + K D + +K +E++ + E+ ++ S +
Sbjct: 1189 IEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSE 1248
Query: 63 KRIIYDSDSESEETLQVKN--AKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKK 120
+DS + + K ++ EK VS + + + E +EE+D +
Sbjct: 1249 VPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAET 1308
Query: 121 AASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKK 180
A + + + HL ++ K+ EE ++ P V + F ++Q+S +K
Sbjct: 1309 AQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEP------GVQESFLDANMQKSREK 1362
Query: 181 MVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKK 240
+ + EL ++ + +++Q+ ED + E H EE L L EE +
Sbjct: 1363 IKDKEETELDSEEEQPSHDTSVVSEQMAGSED-DHEEDSHTKEE----LIELKEEEEIPH 1417
Query: 241 ARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHS 300
+ D E + S+ S + Y +T +SY+ + S E H+
Sbjct: 1418 SELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVE-DCHA 1476
Query: 301 KSSADKIGEVSSPKASSKLAIMKRKE---ESSYKEIEP 335
I V S + S ++ ES Y +I P
Sbjct: 1477 SEHNSPISSVQSHPSQSVRSVSSPNVPALESGYTQISP 1514
Score = 33.1 bits (74), Expect = 1.6
Identities = 74/383 (19%), Positives = 140/383 (36%), Gaps = 57/383 (14%)
Query: 206 QLQLDEDAELERQLHEDEEFARTLA--MLDEEPKTKKARKDTEAGETFSSVQAN------ 257
++ +E+ E E +L E F R + +L + +K+ KD E E
Sbjct: 1066 EIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPV 1125
Query: 258 --LSKAEKHKYPHKVKTAQVSDERKSYSPRKQSK-------------YESSKESQQHSKS 302
L K + P + T+ ++K + K K ++ S+E S
Sbjct: 1126 SLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQ 1185
Query: 303 SADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPA 362
+ VS PKA K I + +E KE P+ +RKE +++ E + ++ + A
Sbjct: 1186 ACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEE-EMQAEAEEAEEGEEEDA 1244
Query: 363 KKESV---SPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLE 419
V SP DS + + E K S+E + E E LE
Sbjct: 1245 ASSEVPAASPADSSNS-PETETKEPEVEEEEEKPRVSEEQRQSEEEQQE---------LE 1294
Query: 420 SIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLI 479
E +E + ++ ++ D G +S K L + ED +
Sbjct: 1295 EPEPEEEED--------AAAETAQNDDHDADDEDDGHLESTKKKELEEQPTRED-----V 1341
Query: 480 RTMPGKKSKY------EIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTS 533
+ PG + + + + + K+E++L+ ++ +S SE +
Sbjct: 1342 KEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSH 1401
Query: 534 KRDSLAKTIKKETDVFWKSLDFK 556
++ L + +K+E ++ LD +
Sbjct: 1402 TKEELIE-LKEEEEIPHSELDLE 1423
>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 56.2 bits (134), Expect = 2e-07
Identities = 65/338 (19%), Positives = 130/338 (38%), Gaps = 17/338 (5%)
Query: 3 IRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKK 62
I + +G+K + ++ + K D + +K +E++ + E+ ++ S +
Sbjct: 1189 IEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSE 1248
Query: 63 KRIIYDSDSESEETLQVKN--AKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKK 120
+DS + + K ++ EK VS + + + E +EE+D +
Sbjct: 1249 VPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAET 1308
Query: 121 AASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKK 180
A + + + HL ++ K+ EE ++ P V + F ++Q+S +K
Sbjct: 1309 AQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEP------GVQESFLDANMQKSREK 1362
Query: 181 MVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKK 240
+ + EL ++ + +++Q+ ED + E H EE L L EE +
Sbjct: 1363 IKDKEETELDSEEEQPSHDTSVVSEQMAGSED-DHEEDSHTKEE----LIELKEEEEIPH 1417
Query: 241 ARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHS 300
+ D E + S+ S + Y +T +SY+ + S E H+
Sbjct: 1418 SELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVE-DCHA 1476
Query: 301 KSSADKIGEVSSPKASSKLAIMKRKE---ESSYKEIEP 335
I V S + S ++ ES Y +I P
Sbjct: 1477 SEHNSPISSVQSHPSQSVRSVSSPNVPALESGYTQISP 1514
Score = 33.1 bits (74), Expect = 1.6
Identities = 74/383 (19%), Positives = 140/383 (36%), Gaps = 57/383 (14%)
Query: 206 QLQLDEDAELERQLHEDEEFARTLA--MLDEEPKTKKARKDTEAGETFSSVQAN------ 257
++ +E+ E E +L E F R + +L + +K+ KD E E
Sbjct: 1066 EIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPV 1125
Query: 258 --LSKAEKHKYPHKVKTAQVSDERKSYSPRKQSK-------------YESSKESQQHSKS 302
L K + P + T+ ++K + K K ++ S+E S
Sbjct: 1126 SLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQ 1185
Query: 303 SADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPA 362
+ VS PKA K I + +E KE P+ +RKE +++ E + ++ + A
Sbjct: 1186 ACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEE-EMQAEAEEAEEGEEEDA 1244
Query: 363 KKESV---SPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLE 419
V SP DS + + E K S+E + E E LE
Sbjct: 1245 ASSEVPAASPADSSNS-PETETKEPEVEEEEEKPRVSEEQRQSEEEQQE---------LE 1294
Query: 420 SIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLI 479
E +E + ++ ++ D G +S K L + ED +
Sbjct: 1295 EPEPEEEED--------AAAETAQNDDHDADDEDDGHLESTKKKELEEQPTRED-----V 1341
Query: 480 RTMPGKKSKY------EIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTS 533
+ PG + + + + + K+E++L+ ++ +S SE +
Sbjct: 1342 KEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSH 1401
Query: 534 KRDSLAKTIKKETDVFWKSLDFK 556
++ L + +K+E ++ LD +
Sbjct: 1402 TKEELIE-LKEEEEIPHSELDLE 1423
>gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform a
[Homo sapiens]
Length = 845
Score = 55.5 bits (132), Expect = 3e-07
Identities = 79/346 (22%), Positives = 141/346 (40%), Gaps = 30/346 (8%)
Query: 9 VIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYD 68
V+ GKK KK +KT +E ++ K+ +E KV +++ +Q+Q KKKR
Sbjct: 27 VVKKGKK-----DKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKR---- 77
Query: 69 SDSESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKEN 128
++ + + K+ E+ + + K+S + +DEED+ K K
Sbjct: 78 ---DTRKGRRKKDVDDDGEEKELMERLKKLS-------VPTSDEEDEVPAPKPRGGKKTK 127
Query: 129 GRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKE 188
G + + L ++ EE K KP P K + +++ K SK K
Sbjct: 128 GGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKA 187
Query: 189 LSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAG 248
QN + L++E K+ ++ ++ E +Q E + A E + + ++ E G
Sbjct: 188 KPQN-KFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQ----GSEEEGEGEEEEEEGG 242
Query: 249 ET-FSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKI 307
E+ A+LSK EK K Q+ ER+ S + + E+ Q SS +
Sbjct: 243 ESKADDPYAHLSKKEKKKL-----KKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAM 297
Query: 308 GEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKT 353
E +S K +I +E + + R+ + G+ KT
Sbjct: 298 LENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKT 343
Score = 32.0 bits (71), Expect = 3.5
Identities = 58/300 (19%), Positives = 110/300 (36%), Gaps = 33/300 (11%)
Query: 286 KQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRK--EESSYKEIEPVASKRKEN 343
KQ E S S +DK+ + K + E+ E E V ++++
Sbjct: 6 KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQ 65
Query: 344 AIKLKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGA 403
+ + + K + T+ KK+ +D E+K + + + + P+G
Sbjct: 66 QQQQQQQQKKKRDTRKGRRKKDV--DDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGG 123
Query: 404 ENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAA 463
+ G +F +S E +E E++ K + N V S+ + A
Sbjct: 124 KKTKGGNVFAALIQDQSEEEEEE----EKHPPKPAKPEKNRINKAV-------SEEQQPA 172
Query: 464 ALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKK- 522
G K +E + ++K+ E KE ++ + + QGK K +++
Sbjct: 173 LKGKKGKEEKS-----KGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQG 227
Query: 523 -------ESESKKSRPTSKRDSLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADD 575
E E ++ + D A KKE K ++++ QVA KA N A++
Sbjct: 228 SEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVA-----SLKAANAAEN 282
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 55.5 bits (132), Expect = 3e-07
Identities = 77/382 (20%), Positives = 144/382 (37%), Gaps = 23/382 (6%)
Query: 22 KKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKN 81
K K+ + T+ KK I ++S +ED +K R+ + +T + N
Sbjct: 385 KMEVKSYTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSN 444
Query: 82 AKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNM 141
AK+ EK V K K ++ V + +D+ F ++ S+S E+G LG+S
Sbjct: 445 AKQQKEKNKVKKKRKKETKGREVRFGKRSDK---FCSSESESESSESGEDDRDSLGSSGC 501
Query: 142 KKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQN--------- 192
K S + + TS G+ + Q+ N K +
Sbjct: 502 LKGSPLVLKDPSLFSSLSASSTS---SHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPA 558
Query: 193 -TDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETF 251
++ S L+D + + +L +++ + E + + + K + +
Sbjct: 559 WSEVSSLSD---STRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSA 615
Query: 252 SSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADK-IGEV 310
L K K HK K + E+ S ++ K +S + SK +DK I
Sbjct: 616 EGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLE 675
Query: 311 SSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPE 370
+ +KL ++K + +K+ E ++ + E L + K+ K+ K + K+
Sbjct: 676 NDLSTENKLKVLKH-DRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDT--NKDISRSF 732
Query: 371 DSEKKRTNYQAYRSYLNREGPK 392
EK R+N L + PK
Sbjct: 733 REEKDRSNKAEKERSLKEKSPK 754
Score = 46.6 bits (109), Expect = 1e-04
Identities = 123/612 (20%), Positives = 221/612 (36%), Gaps = 82/612 (13%)
Query: 15 KLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESE 74
KL+ ETVK++ K + + + K+ +E +K+ D+ K K+K ++E
Sbjct: 875 KLILETVKEDSKERRRDSRAREKRDYREPFFR--KKDRDYLDKNSEKRKE-------QTE 925
Query: 75 ETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNS 134
+ V +K S R+D + E + +K +E R
Sbjct: 926 KHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKER--------RDGRAKPEEAHREELK 977
Query: 135 HLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTD 194
G + K++ + K L P + + G + +K + KE S + D
Sbjct: 978 ECGCESGFKDKSDGDF-GKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKD 1036
Query: 195 ESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSV 254
+S +++I ++ Q +D+EF + E+ TK+ KDT +
Sbjct: 1037 KS---EKSILEKCQ------------KDKEFDKCFK---EKKDTKEKHKDTHGKDKERKA 1078
Query: 255 QANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKY------ESSKESQQHSKSSADKIG 308
+ K +K K + + S+++ +++S Y + S++ + S K+G
Sbjct: 1079 SLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMG 1138
Query: 309 EVSS--------PKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLK----GETKTPKK 356
E S K + A + S + P K KE + K + KK
Sbjct: 1139 EASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKK 1198
Query: 357 TKSSPAKKESVSPEDSEK--KRTNYQAYRSYLNREGPKALGSKEIPK-GAENCLEGLIFV 413
K KE E +EK R + + S +++ + L K K AE+ +
Sbjct: 1199 EKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKE 1258
Query: 414 ITGVLESIER------DEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGT 467
+ S ER D KSL+E+ + + +N + S S +D+ G
Sbjct: 1259 KSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKI-SEVSSDSFTDRGQEPGL 1317
Query: 468 KIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESK 527
E PG E A E KE + R + + +KKE K
Sbjct: 1318 TAFLEVSFTE----PPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEK 1373
Query: 528 KSRPT------SKRDS-LAKTIKKETDVFWKSLDFKEQVAEET-------SGDSKARNLA 573
K + S++DS + E D + S + K + +E S + K +N +
Sbjct: 1374 KEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDS 1433
Query: 574 DDSSENKVENLL 585
+ K+E L
Sbjct: 1434 EREPSKKIEKEL 1445
Score = 43.1 bits (100), Expect = 0.002
Identities = 121/681 (17%), Positives = 247/681 (36%), Gaps = 99/681 (14%)
Query: 11 PSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSD 70
P +KL ++ +K+K L+ K +KE K+ S KE FK+ + KK +Y D
Sbjct: 753 PKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKI-SKEKEKIFKEDKEKLKKEKVYRED 811
Query: 71 SESEETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGR 130
S +E +K + +D +S+ D+ D +
Sbjct: 812 SAFDE---------------YCNKNQFLENEDTKFSLSD-DQRDRWF------------- 842
Query: 131 STNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELS 190
S++ + + K ++ SP+ T + + K + +R+ S
Sbjct: 843 --------SDLSDSSFDFKGEDSWDSPV--TDYRDMKSDSVAKLILETVKEDSKERRRDS 892
Query: 191 QNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAG-- 248
+ ++ + K+ + D E++ + E+ L E K KK R+ EAG
Sbjct: 893 RAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSE--KDKKRRESAEAGRD 950
Query: 249 --ETFSSVQANLSKAEKHKYPHKVKTAQVSDER-----------------KSYSPRKQSK 289
+ S + K + H+ + + E + + P ++ +
Sbjct: 951 RKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKE 1010
Query: 290 YESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKG 349
+ + ++ K+ ++ E SS K S+ +I+++ ++ KE + ++K+ K K
Sbjct: 1011 KKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQKD--KEFDKCFKEKKDTKEKHKD 1068
Query: 350 ETKTPKKTKSS----PAKKES-----VSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIP 400
K+ K+S KKE +S + SEKK +S+ + + + E
Sbjct: 1069 THGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIAD----IFTDESE 1124
Query: 401 KGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSD 460
++C+ G F + + D + E + K ++ R + D
Sbjct: 1125 DDRDSCM-GSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRD 1183
Query: 461 KAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPS 520
+ G D + KK K + K + ++ T K + K
Sbjct: 1184 RRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAE 1243
Query: 521 KKESESKKSRPTSKRDSLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSE-- 578
KK + K++ K S + K+ +S D ++ + E+ + +DS++
Sbjct: 1244 KKHAAEDKAKSKHKEKSDKEHSKERKSS--RSADAEKSLLEKLE-EEALHEYREDSNDKI 1300
Query: 579 NKVENLLWVDKYKPTSLKTII----------GQQGDQSCANKLLRWLRNWQKSSSEDKK- 627
++V + + D+ + L + + + +C + L+ + SSS KK
Sbjct: 1301 SEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKS 1360
Query: 628 ----HAKFGKFSGKDDGSSFK 644
AK K K+ G +K
Sbjct: 1361 HDRERAKKEKAEKKEKGEDYK 1381
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 55.5 bits (132), Expect = 3e-07
Identities = 91/427 (21%), Positives = 168/427 (39%), Gaps = 83/427 (19%)
Query: 19 ETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFK----QKQPSKK------------ 62
E K EKT+S ETL+ +EIK + ++D FK Q PS K
Sbjct: 1444 EQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDI 1503
Query: 63 --KRIIYDSDSESEETLQVKNAKKPPEKLPV---SSKPGKISRQDPVTYISETDEEDDFM 117
+R YDS ES E+ +N+ P K SS + ++D + EE+DF+
Sbjct: 1504 TTRREPYDSVEESSES---ENSPVPQRKRRTSVGSSSSDEYKQEDS----QGSGEEEDFI 1556
Query: 118 CKK--AASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQ 175
K+ S ++ S + + +K+ +T+++ K
Sbjct: 1557 RKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKK-------------------EET 1597
Query: 176 RSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLH--EDEEFARTLAMLD 233
+ K+ A K + L++ + S +DEDA H +DE F + +
Sbjct: 1598 KGKGKITAGKHRRLTRKSSTS------------IDEDAGRRHSWHDEDDEAFDESPELKY 1645
Query: 234 EEPKTKKARKDTEAG----ETFSSVQANLSKAEKHK-YPHKVKTAQVSDERKSY------ 282
E K++++ + G F +++ N + A+K+ + KT+ DE
Sbjct: 1646 RETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLT 1705
Query: 283 -SPRKQSKYESSKE------SQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEP 335
SP +S+ E S + S +S + E S S K K++ ++ ++ P
Sbjct: 1706 DSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGP 1765
Query: 336 VASKRKENA--IKLKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKA 393
+ ++++ +L+ E + K+ + ++ S+K + + R+ RE PK
Sbjct: 1766 LLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKT 1825
Query: 394 LGSKEIP 400
S P
Sbjct: 1826 PPSNLSP 1832
Score = 49.7 bits (117), Expect = 2e-05
Identities = 87/389 (22%), Positives = 153/389 (39%), Gaps = 58/389 (14%)
Query: 10 IPSGKKLVS--ETVKKNEKTKSDEETLKAKKGIKEIK--VNSSRKEDDFKQKQ------- 58
+P KLV E K E K E +K +++I V + +K+++ K ++
Sbjct: 1150 VPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQ 1209
Query: 59 -----PSKKKRIIYDSDSESEETLQVKNAKKP-PE--KLPVSSKPGKISRQDPVTYISET 110
P +KK I + SEE + KKP PE KL +K Q S+
Sbjct: 1210 EKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQV 1269
Query: 111 DEEDDFMCKKAASKSKENGRSTNSHL-----GT--SNMKKNEENTKT-KNKPLSPIKLTP 162
++ + + A K+ + G+ + + GT S K++++ TKT K +P P P
Sbjct: 1270 QIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP 1329
Query: 163 TSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHED 222
V + +S++ + Q ++G + + I+ L E+ + D
Sbjct: 1330 DQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSL-----GEIPSLIPTD 1384
Query: 223 EEFARTLAMLDEEPKTKKARKDTEAGETFSSVQANLS---------KAEKHKYPHKVKTA 273
E+ D + ++ + S+V + L K+EK PH+V
Sbjct: 1385 EKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPE 1444
Query: 274 QVSDERKSYSPRKQSKY----ESSKESQQHSKSSADKIGEVSSP-----KASSKLA--IM 322
Q D+ K+ S + + E KESQ+ K + K + P K S+ I
Sbjct: 1445 QPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDIT 1504
Query: 323 KRK------EESSYKEIEPVASKRKENAI 345
R+ EESS E PV +++ ++
Sbjct: 1505 TRREPYDSVEESSESENSPVPQRKRRTSV 1533
Score = 33.1 bits (74), Expect = 1.6
Identities = 63/269 (23%), Positives = 102/269 (37%), Gaps = 25/269 (9%)
Query: 42 EIKVNSSRKEDDFKQKQPS--KKKRIIYDSDSESEETLQVKNAKKPPEK-LPVSSKPGKI 98
EI +S + D Q PS K +++Y S +++A P EK LP P K+
Sbjct: 3597 EIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKV 3656
Query: 99 SRQDPVTYISETDEEDDFMCKKAASKSK-------ENGRSTNSHLGTSNMKKNEENTKTK 151
D + + + M +++ S K E+ R+ + T T T
Sbjct: 3657 LHPD-MAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQY--TEGYTTKGSQTMTS 3713
Query: 152 NKPLSPIKLT-PTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLD 210
+ +K T P + TG+ + S+R+ NT A AK LQ D
Sbjct: 3714 SGAQKKVKRTLPNPPPEEISTGTQSTFSTMGTVSRRRICRTNT-------MARAKILQ-D 3765
Query: 211 EDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSVQANLSKAEKHKYPHKV 270
D EL+ E + + A LDEE K A+ +A L + EK + +
Sbjct: 3766 IDRELDLVERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRE---RA 3822
Query: 271 KTAQVSDERKSYSPRKQSKYESSKESQQH 299
V+++R S + S ++ QH
Sbjct: 3823 YLQGVAEDRDYMSDSEVSSTRPTRIESQH 3851
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 55.5 bits (132), Expect = 3e-07
Identities = 91/427 (21%), Positives = 168/427 (39%), Gaps = 83/427 (19%)
Query: 19 ETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFK----QKQPSKK------------ 62
E K EKT+S ETL+ +EIK + ++D FK Q PS K
Sbjct: 1444 EQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDI 1503
Query: 63 --KRIIYDSDSESEETLQVKNAKKPPEKLPV---SSKPGKISRQDPVTYISETDEEDDFM 117
+R YDS ES E+ +N+ P K SS + ++D + EE+DF+
Sbjct: 1504 TTRREPYDSVEESSES---ENSPVPQRKRRTSVGSSSSDEYKQEDS----QGSGEEEDFI 1556
Query: 118 CKK--AASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQ 175
K+ S ++ S + + +K+ +T+++ K
Sbjct: 1557 RKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKK-------------------EET 1597
Query: 176 RSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLH--EDEEFARTLAMLD 233
+ K+ A K + L++ + S +DEDA H +DE F + +
Sbjct: 1598 KGKGKITAGKHRRLTRKSSTS------------IDEDAGRRHSWHDEDDEAFDESPELKY 1645
Query: 234 EEPKTKKARKDTEAG----ETFSSVQANLSKAEKHK-YPHKVKTAQVSDERKSY------ 282
E K++++ + G F +++ N + A+K+ + KT+ DE
Sbjct: 1646 RETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLT 1705
Query: 283 -SPRKQSKYESSKE------SQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEP 335
SP +S+ E S + S +S + E S S K K++ ++ ++ P
Sbjct: 1706 DSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGP 1765
Query: 336 VASKRKENA--IKLKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKA 393
+ ++++ +L+ E + K+ + ++ S+K + + R+ RE PK
Sbjct: 1766 LLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKT 1825
Query: 394 LGSKEIP 400
S P
Sbjct: 1826 PPSNLSP 1832
Score = 49.7 bits (117), Expect = 2e-05
Identities = 87/389 (22%), Positives = 153/389 (39%), Gaps = 58/389 (14%)
Query: 10 IPSGKKLVS--ETVKKNEKTKSDEETLKAKKGIKEIK--VNSSRKEDDFKQKQ------- 58
+P KLV E K E K E +K +++I V + +K+++ K ++
Sbjct: 1150 VPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQ 1209
Query: 59 -----PSKKKRIIYDSDSESEETLQVKNAKKP-PE--KLPVSSKPGKISRQDPVTYISET 110
P +KK I + SEE + KKP PE KL +K Q S+
Sbjct: 1210 EKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQV 1269
Query: 111 DEEDDFMCKKAASKSKENGRSTNSHL-----GT--SNMKKNEENTKT-KNKPLSPIKLTP 162
++ + + A K+ + G+ + + GT S K++++ TKT K +P P P
Sbjct: 1270 QIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP 1329
Query: 163 TSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHED 222
V + +S++ + Q ++G + + I+ L E+ + D
Sbjct: 1330 DQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSL-----GEIPSLIPTD 1384
Query: 223 EEFARTLAMLDEEPKTKKARKDTEAGETFSSVQANLS---------KAEKHKYPHKVKTA 273
E+ D + ++ + S+V + L K+EK PH+V
Sbjct: 1385 EKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPE 1444
Query: 274 QVSDERKSYSPRKQSKY----ESSKESQQHSKSSADKIGEVSSP-----KASSKLA--IM 322
Q D+ K+ S + + E KESQ+ K + K + P K S+ I
Sbjct: 1445 QPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDIT 1504
Query: 323 KRK------EESSYKEIEPVASKRKENAI 345
R+ EESS E PV +++ ++
Sbjct: 1505 TRREPYDSVEESSESENSPVPQRKRRTSV 1533
Score = 33.1 bits (74), Expect = 1.6
Identities = 63/269 (23%), Positives = 102/269 (37%), Gaps = 25/269 (9%)
Query: 42 EIKVNSSRKEDDFKQKQPS--KKKRIIYDSDSESEETLQVKNAKKPPEK-LPVSSKPGKI 98
EI +S + D Q PS K +++Y S +++A P EK LP P K+
Sbjct: 3597 EIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKV 3656
Query: 99 SRQDPVTYISETDEEDDFMCKKAASKSK-------ENGRSTNSHLGTSNMKKNEENTKTK 151
D + + + M +++ S K E+ R+ + T T T
Sbjct: 3657 LHPD-MAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQY--TEGYTTKGSQTMTS 3713
Query: 152 NKPLSPIKLT-PTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLD 210
+ +K T P + TG+ + S+R+ NT A AK LQ D
Sbjct: 3714 SGAQKKVKRTLPNPPPEEISTGTQSTFSTMGTVSRRRICRTNT-------MARAKILQ-D 3765
Query: 211 EDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSVQANLSKAEKHKYPHKV 270
D EL+ E + + A LDEE K A+ +A L + EK + +
Sbjct: 3766 IDRELDLVERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRE---RA 3822
Query: 271 KTAQVSDERKSYSPRKQSKYESSKESQQH 299
V+++R S + S ++ QH
Sbjct: 3823 YLQGVAEDRDYMSDSEVSSTRPTRIESQH 3851
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 55.1 bits (131), Expect = 4e-07
Identities = 135/616 (21%), Positives = 221/616 (35%), Gaps = 80/616 (12%)
Query: 27 TKSDEE---TLKAKKGI-----KEIKVNSSRKEDDFKQ--KQPSKKKRIIYDSDSESEET 76
+ SDEE T+K K+ + K+ K NSS D + K P K+ D +S+S+E
Sbjct: 637 SNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEM 696
Query: 77 LQV-KNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSH 135
L + K + + +I Y +T D K+ KS +G ++
Sbjct: 697 LAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKR-KSSTSGSDFDTK 755
Query: 136 LGTS------NMKKNEENTKTKN---------KPLSPIKLTPTS------VLDYFGTGSV 174
G S + KK + +++ N K +S I T+ D+ +
Sbjct: 756 KGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDE 815
Query: 175 QRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDE 234
+ S K M K L T + G +D+A KQ + + + E + +D + + D
Sbjct: 816 KHSKKGMDNQGHKNLK--TSQEGSSDDAERKQ-ERETFSSAEGTVDKDTTI---MELRDR 869
Query: 235 EPKTKKARKDTEA-------GETFSSVQANLSKAEKHKYPH-KVKTAQ-VSDERKSYSPR 285
PK ++A T+ ++F+S++ K K H K KT + V D + +
Sbjct: 870 LPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEK 929
Query: 286 KQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAI 345
K +S + S+ K S E P K I ++ S + +R+E
Sbjct: 930 FLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICH 989
Query: 346 KLKGETKTPKKTKSSPAKKESVSPEDSEKK-RTNYQAYRSYLNREGPKALGSKEIPKGAE 404
KG + T K + + + S+KK + A +S + + K+ GA
Sbjct: 990 FPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAY 1049
Query: 405 NCLEGLIFVITGVLESIERDEAKSLIERYGGKVTG-----------------NVSKKTNY 447
E + G +D + S E+Y K G N+S K N
Sbjct: 1050 G-REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNT 1108
Query: 448 LVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTP 507
+ SG S SD + ED RT KK AV + KK + L +
Sbjct: 1109 KEI--QSGSSSSDAEES------SEDNKKKKQRTSSKKK-----AVIVKEKKRNSLRTST 1155
Query: 508 QKNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIKKETDVFWKSLDFKEQVAEETSGDS 567
++ S S E + + S D E V F + +E S
Sbjct: 1156 KRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKS 1215
Query: 568 KARNLADDSSENKVEN 583
+ DD +N EN
Sbjct: 1216 VPVTVDDDDDDNDPEN 1231
Score = 55.1 bits (131), Expect = 4e-07
Identities = 126/644 (19%), Positives = 241/644 (37%), Gaps = 59/644 (9%)
Query: 15 KLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESE 74
K E + + K + ET + +G + D +KQ + D S E
Sbjct: 831 KTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKE 890
Query: 75 ET---LQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRS 131
++ L+V+ + EK QD ++ I+E + D + + K++ +
Sbjct: 891 QSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKG 950
Query: 132 TNSHLGTSNMKKNEENTKTKNKPLSP--IKLTPTSVLDYFGTGSVQRSN-----KKMVAS 184
T S+ KK + + + S KL + +F G Q N +K
Sbjct: 951 TEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKK 1010
Query: 185 KRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKD 244
R + S+ DE L+D A + D E + ++ + R K+ + R+D
Sbjct: 1011 IRDKTSKKKDE--LSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQD 1068
Query: 245 TEAGET--FSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKS 302
+ +T +S + + ++K ++K ++ + R S R + +S S +S
Sbjct: 1069 CSSSDTEKYSMKEDGCNSSDK-----RLKRIELRERRNLSSKRNTKEIQSGSSSSDAEES 1123
Query: 303 SADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPA 362
S D + + K I+K K+ +S + ++KRK+ I + ++S
Sbjct: 1124 SEDNKKKKQRTSSKKKAVIVKEKKRNSLR----TSTKRKQADITSSSSSDIEDDDQNSIG 1179
Query: 363 KKESVSPEDSEKKRTN---YQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLE 419
E S E K T ++ + G +AL SK +P ++ + +
Sbjct: 1180 --EGSSDEQKIKPVTENLVLSSHTGFCQSSGDEAL-SKSVPVTVDDDDDDN--------D 1228
Query: 420 SIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLI 479
R K L+E ++ N+S + SD G K + N
Sbjct: 1229 PENRIAKKMLLE----EIKANLSSDED----------GSSDDEPEEGKKRTGKQNEEN-- 1272
Query: 480 RTMPG-KKSKYEIAVETEM-KKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDS 537
PG +++K ++ E++ +ESK R + ++ K +S + E KK++P ++
Sbjct: 1273 ---PGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGES-GEEKKTKPKEHKEV 1328
Query: 538 LAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKT 597
+ +K + + DF+E E +S+ S K E YK +
Sbjct: 1329 KGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRR 1388
Query: 598 IIGQQGDQSCANKLLRWLRNWQKSSSEDKKHAKFGKFSGKDDGS 641
I Q D S NK +K E+++ + + ++D S
Sbjct: 1389 RIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDS 1432
Score = 51.2 bits (121), Expect = 6e-06
Identities = 123/644 (19%), Positives = 240/644 (37%), Gaps = 94/644 (14%)
Query: 16 LVSETVKKNEKTKSDEETLK-AKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESE 74
+ + +KK++ ++ E+ K +KKG +E K K DFK+K +++ Y+S S+
Sbjct: 926 IAEKFLKKDQSDETSEDDKKQSKKGTEEKK-----KPSDFKKKVIKMEQQ--YESSSDGT 978
Query: 75 ETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNS 134
E L PE+ + P I + T ++ +++ + K + K E
Sbjct: 979 EKL--------PEREEICHFPKGIKQIKNGT--TDGEKKSKKIRDKTSKKKDELSDYAEK 1028
Query: 135 HLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTD 194
G + + E+ K+KN K + G R + +S ++ S D
Sbjct: 1029 STGKGDSCDSSEDKKSKNGAYGREKKRCKLL------GKSSRKRQDCSSSDTEKYSMKED 1082
Query: 195 ESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSV 254
+D+ + K+++L E L +K+ K+ ++G + S
Sbjct: 1083 GCNSSDKRL-KRIELRERRNL---------------------SSKRNTKEIQSGSSSSDA 1120
Query: 255 QANL--SKAEKHKYPHKVKTAQVSDER----KSYSPRKQSKYESSKESQQHSKSSADKIG 308
+ + +K +K + K K V +++ ++ + RKQ+ SS S + IG
Sbjct: 1121 EESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIED-DDQNSIG 1179
Query: 309 EVSSPK-----------ASSKLAIMKRKEESSYKEIEPVA------SKRKENAIKLKGET 351
E SS + SS + + + + PV EN I K
Sbjct: 1180 EGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLL 1239
Query: 352 KTPKKTKSSPAKKESVSPEDSEKKRTNYQ--------AYRSYLNREGPKALGSKEIPKGA 403
+ K SS S + KKRT Q ++ +N E + P+
Sbjct: 1240 EEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYR 1299
Query: 404 ENCLEGLIFVI---TGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSD 460
L + V +G + + E K + R KV+ S+ +++ G S+S+
Sbjct: 1300 HRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESE 1359
Query: 461 KAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPS 520
T+ + L R+ KK + I V+ + E+K ++ + + +
Sbjct: 1360 DEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEE 1419
Query: 521 KKESESKKSRPTSK-----RDSLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADD 575
++E E + SK R + K +K + L + Q A + + + R +
Sbjct: 1420 EEEEEEEDENDDSKSPGKGRKKIRKILKDD------KLRTETQNALKEEEERRKRIAERE 1473
Query: 576 SSENKVENLLWVDKYKPTS--LKTIIGQQGDQSCANKLLRWLRN 617
K+ ++ ++ PT + T + D+ L++ RN
Sbjct: 1474 REREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRN 1517
Score = 48.9 bits (115), Expect = 3e-05
Identities = 79/391 (20%), Positives = 147/391 (37%), Gaps = 94/391 (24%)
Query: 15 KLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESE 74
K V TV ++ E + K ++EIK N S ED +P + K+ + ++E
Sbjct: 1214 KSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKK---RTGKQNE 1270
Query: 75 ETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNS 134
E PG ++ V S++D E+ + K + R
Sbjct: 1271 E------------------NPGDEEAKNQVNSESDSDSEE-------SKKPRYRHRLLRH 1305
Query: 135 HLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTD 194
L S+ + EE KTK K +K ++RK S++++
Sbjct: 1306 KLTVSDGESGEEK-KTKPKEHKEVK----------------------GRNRRKVSSEDSE 1342
Query: 195 ESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSV 254
+S + +++++ ED ++ P+T+ A+K E E S
Sbjct: 1343 DSDFQESGVSEEVSESED--------------------EQRPRTRSAKK-AELEENQRSY 1381
Query: 255 QANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSP- 313
K +K + KV+ S+ + + ++ K E +E ++ + D+ + SP
Sbjct: 1382 -----KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPG 1436
Query: 314 KASSKL-AIMK------------RKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSS 360
K K+ I+K ++EE K I +R++ ++ E +P K
Sbjct: 1437 KGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTK---C 1493
Query: 361 PAKKESVSPEDSEKKRTNYQAYRSYLNREGP 391
P + V ED E K Q +R+ + + P
Sbjct: 1494 PITTKLVLDEDEETKEPLVQVHRNMVIKLKP 1524
Score = 47.4 bits (111), Expect = 8e-05
Identities = 137/680 (20%), Positives = 247/680 (36%), Gaps = 121/680 (17%)
Query: 21 VKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQP--------SKKKRII------ 66
+ N KT D +T K + K SS DF K+ SKKKR
Sbjct: 719 IHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSN 778
Query: 67 YDSDSESE--ETLQVKNAKKPPEKLPVS-----------SKPGKISRQDPVTYISETDEE 113
YDS+ E E ++ A+ +++P + SK G ++ S+
Sbjct: 779 YDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSS 838
Query: 114 DDFMCKK-----AASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDY 168
DD K+ ++++ + +T L KK + + T K + L+
Sbjct: 839 DDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEV 898
Query: 169 FGTGSVQRSNKKMVASKRKELSQNTDESGLND--EAIAKQLQLDEDAELER--------Q 218
+ +K + K++ + GL+D E K+ Q DE +E ++ +
Sbjct: 899 RKVAETKEKSKHLKTKTCKKV-----QDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEE 953
Query: 219 LHEDEEFARTLAMLDE--EPKTKKARKDTEAGET------FSSVQANLSKAEKHKYPHKV 270
+ +F + + +++ E + K E E ++ + EK +
Sbjct: 954 KKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRD 1013
Query: 271 KTAQVSDERKSYSPRKQSKYESSKESQQ---------HSKSSADKIGEVSSPK---ASSK 318
KT++ DE Y+ + K +S S+ K +G+ S + +SS
Sbjct: 1014 KTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSD 1073
Query: 319 LAIMKRKEE---SSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPEDSEKK 375
KE+ SS K ++ + + + N + K TK + SS +ES +K+
Sbjct: 1074 TEKYSMKEDGCNSSDKRLKRIELRERRN-LSSKRNTKEIQSGSSSSDAEESSEDNKKKKQ 1132
Query: 376 RTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGG 435
RT+ + + + +L + K A+ + + IE D+ S+ E G
Sbjct: 1133 RTSSKKKAVIVKEKKRNSLRTSTKRKQAD--------ITSSSSSDIEDDDQNSIGE--GS 1182
Query: 436 KVTGNVSKKTNYLVMGRDSG--QSKSDKAAALGTKI-IDEDGLLNLIRTMPGKKSKY-EI 491
+ T LV+ +G QS D+A + + +D+D N KK EI
Sbjct: 1183 SDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEI 1242
Query: 492 AVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIKKETDVFWK 551
++ + P++ + K + E K++ S+ DS ++ KK +
Sbjct: 1243 KANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPR-YRHR 1301
Query: 552 SLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKL 611
L K V++ SG+ K K KP K + G
Sbjct: 1302 LLRHKLTVSDGESGEEK--------------------KTKPKEHKEVKG----------- 1330
Query: 612 LRWLRNWQKSSSEDKKHAKF 631
RN +K SSED + + F
Sbjct: 1331 ----RNRRKVSSEDSEDSDF 1346
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 55.1 bits (131), Expect = 4e-07
Identities = 135/616 (21%), Positives = 221/616 (35%), Gaps = 80/616 (12%)
Query: 27 TKSDEE---TLKAKKGI-----KEIKVNSSRKEDDFKQ--KQPSKKKRIIYDSDSESEET 76
+ SDEE T+K K+ + K+ K NSS D + K P K+ D +S+S+E
Sbjct: 675 SNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEM 734
Query: 77 LQV-KNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSH 135
L + K + + +I Y +T D K+ KS +G ++
Sbjct: 735 LAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKR-KSSTSGSDFDTK 793
Query: 136 LGTS------NMKKNEENTKTKN---------KPLSPIKLTPTS------VLDYFGTGSV 174
G S + KK + +++ N K +S I T+ D+ +
Sbjct: 794 KGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDE 853
Query: 175 QRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDE 234
+ S K M K L T + G +D+A KQ + + + E + +D + + D
Sbjct: 854 KHSKKGMDNQGHKNLK--TSQEGSSDDAERKQ-ERETFSSAEGTVDKDTTI---MELRDR 907
Query: 235 EPKTKKARKDTEA-------GETFSSVQANLSKAEKHKYPH-KVKTAQ-VSDERKSYSPR 285
PK ++A T+ ++F+S++ K K H K KT + V D + +
Sbjct: 908 LPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEK 967
Query: 286 KQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAI 345
K +S + S+ K S E P K I ++ S + +R+E
Sbjct: 968 FLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICH 1027
Query: 346 KLKGETKTPKKTKSSPAKKESVSPEDSEKK-RTNYQAYRSYLNREGPKALGSKEIPKGAE 404
KG + T K + + + S+KK + A +S + + K+ GA
Sbjct: 1028 FPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAY 1087
Query: 405 NCLEGLIFVITGVLESIERDEAKSLIERYGGKVTG-----------------NVSKKTNY 447
E + G +D + S E+Y K G N+S K N
Sbjct: 1088 G-REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNT 1146
Query: 448 LVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTP 507
+ SG S SD + ED RT KK AV + KK + L +
Sbjct: 1147 KEI--QSGSSSSDAEES------SEDNKKKKQRTSSKKK-----AVIVKEKKRNSLRTST 1193
Query: 508 QKNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIKKETDVFWKSLDFKEQVAEETSGDS 567
++ S S E + + S D E V F + +E S
Sbjct: 1194 KRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKS 1253
Query: 568 KARNLADDSSENKVEN 583
+ DD +N EN
Sbjct: 1254 VPVTVDDDDDDNDPEN 1269
Score = 55.1 bits (131), Expect = 4e-07
Identities = 126/644 (19%), Positives = 241/644 (37%), Gaps = 59/644 (9%)
Query: 15 KLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESE 74
K E + + K + ET + +G + D +KQ + D S E
Sbjct: 869 KTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKE 928
Query: 75 ET---LQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRS 131
++ L+V+ + EK QD ++ I+E + D + + K++ +
Sbjct: 929 QSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKG 988
Query: 132 TNSHLGTSNMKKNEENTKTKNKPLSP--IKLTPTSVLDYFGTGSVQRSN-----KKMVAS 184
T S+ KK + + + S KL + +F G Q N +K
Sbjct: 989 TEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKK 1048
Query: 185 KRKELSQNTDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKD 244
R + S+ DE L+D A + D E + ++ + R K+ + R+D
Sbjct: 1049 IRDKTSKKKDE--LSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQD 1106
Query: 245 TEAGET--FSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKS 302
+ +T +S + + ++K ++K ++ + R S R + +S S +S
Sbjct: 1107 CSSSDTEKYSMKEDGCNSSDK-----RLKRIELRERRNLSSKRNTKEIQSGSSSSDAEES 1161
Query: 303 SADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPA 362
S D + + K I+K K+ +S + ++KRK+ I + ++S
Sbjct: 1162 SEDNKKKKQRTSSKKKAVIVKEKKRNSLR----TSTKRKQADITSSSSSDIEDDDQNSIG 1217
Query: 363 KKESVSPEDSEKKRTN---YQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLE 419
E S E K T ++ + G +AL SK +P ++ + +
Sbjct: 1218 --EGSSDEQKIKPVTENLVLSSHTGFCQSSGDEAL-SKSVPVTVDDDDDDN--------D 1266
Query: 420 SIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLI 479
R K L+E ++ N+S + SD G K + N
Sbjct: 1267 PENRIAKKMLLE----EIKANLSSDED----------GSSDDEPEEGKKRTGKQNEEN-- 1310
Query: 480 RTMPG-KKSKYEIAVETEM-KKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDS 537
PG +++K ++ E++ +ESK R + ++ K +S + E KK++P ++
Sbjct: 1311 ---PGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGES-GEEKKTKPKEHKEV 1366
Query: 538 LAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKT 597
+ +K + + DF+E E +S+ S K E YK +
Sbjct: 1367 KGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRR 1426
Query: 598 IIGQQGDQSCANKLLRWLRNWQKSSSEDKKHAKFGKFSGKDDGS 641
I Q D S NK +K E+++ + + ++D S
Sbjct: 1427 RIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDS 1470
Score = 51.2 bits (121), Expect = 6e-06
Identities = 123/644 (19%), Positives = 240/644 (37%), Gaps = 94/644 (14%)
Query: 16 LVSETVKKNEKTKSDEETLK-AKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESE 74
+ + +KK++ ++ E+ K +KKG +E K K DFK+K +++ Y+S S+
Sbjct: 964 IAEKFLKKDQSDETSEDDKKQSKKGTEEKK-----KPSDFKKKVIKMEQQ--YESSSDGT 1016
Query: 75 ETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNS 134
E L PE+ + P I + T ++ +++ + K + K E
Sbjct: 1017 EKL--------PEREEICHFPKGIKQIKNGT--TDGEKKSKKIRDKTSKKKDELSDYAEK 1066
Query: 135 HLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTD 194
G + + E+ K+KN K + G R + +S ++ S D
Sbjct: 1067 STGKGDSCDSSEDKKSKNGAYGREKKRCKLL------GKSSRKRQDCSSSDTEKYSMKED 1120
Query: 195 ESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSV 254
+D+ + K+++L E L +K+ K+ ++G + S
Sbjct: 1121 GCNSSDKRL-KRIELRERRNL---------------------SSKRNTKEIQSGSSSSDA 1158
Query: 255 QANL--SKAEKHKYPHKVKTAQVSDER----KSYSPRKQSKYESSKESQQHSKSSADKIG 308
+ + +K +K + K K V +++ ++ + RKQ+ SS S + IG
Sbjct: 1159 EESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIED-DDQNSIG 1217
Query: 309 EVSSPK-----------ASSKLAIMKRKEESSYKEIEPVA------SKRKENAIKLKGET 351
E SS + SS + + + + PV EN I K
Sbjct: 1218 EGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLL 1277
Query: 352 KTPKKTKSSPAKKESVSPEDSEKKRTNYQ--------AYRSYLNREGPKALGSKEIPKGA 403
+ K SS S + KKRT Q ++ +N E + P+
Sbjct: 1278 EEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYR 1337
Query: 404 ENCLEGLIFVI---TGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSD 460
L + V +G + + E K + R KV+ S+ +++ G S+S+
Sbjct: 1338 HRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESE 1397
Query: 461 KAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPS 520
T+ + L R+ KK + I V+ + E+K ++ + + +
Sbjct: 1398 DEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEE 1457
Query: 521 KKESESKKSRPTSK-----RDSLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADD 575
++E E + SK R + K +K + L + Q A + + + R +
Sbjct: 1458 EEEEEEEDENDDSKSPGKGRKKIRKILKDD------KLRTETQNALKEEEERRKRIAERE 1511
Query: 576 SSENKVENLLWVDKYKPTS--LKTIIGQQGDQSCANKLLRWLRN 617
K+ ++ ++ PT + T + D+ L++ RN
Sbjct: 1512 REREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRN 1555
Score = 48.9 bits (115), Expect = 3e-05
Identities = 79/391 (20%), Positives = 147/391 (37%), Gaps = 94/391 (24%)
Query: 15 KLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESE 74
K V TV ++ E + K ++EIK N S ED +P + K+ + ++E
Sbjct: 1252 KSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKK---RTGKQNE 1308
Query: 75 ETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNS 134
E PG ++ V S++D E+ + K + R
Sbjct: 1309 E------------------NPGDEEAKNQVNSESDSDSEE-------SKKPRYRHRLLRH 1343
Query: 135 HLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTD 194
L S+ + EE KTK K +K ++RK S++++
Sbjct: 1344 KLTVSDGESGEEK-KTKPKEHKEVK----------------------GRNRRKVSSEDSE 1380
Query: 195 ESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSV 254
+S + +++++ ED ++ P+T+ A+K E E S
Sbjct: 1381 DSDFQESGVSEEVSESED--------------------EQRPRTRSAKK-AELEENQRSY 1419
Query: 255 QANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSP- 313
K +K + KV+ S+ + + ++ K E +E ++ + D+ + SP
Sbjct: 1420 -----KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPG 1474
Query: 314 KASSKL-AIMK------------RKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSS 360
K K+ I+K ++EE K I +R++ ++ E +P K
Sbjct: 1475 KGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTK---C 1531
Query: 361 PAKKESVSPEDSEKKRTNYQAYRSYLNREGP 391
P + V ED E K Q +R+ + + P
Sbjct: 1532 PITTKLVLDEDEETKEPLVQVHRNMVIKLKP 1562
Score = 47.4 bits (111), Expect = 8e-05
Identities = 137/680 (20%), Positives = 247/680 (36%), Gaps = 121/680 (17%)
Query: 21 VKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQP--------SKKKRII------ 66
+ N KT D +T K + K SS DF K+ SKKKR
Sbjct: 757 IHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSN 816
Query: 67 YDSDSESE--ETLQVKNAKKPPEKLPVS-----------SKPGKISRQDPVTYISETDEE 113
YDS+ E E ++ A+ +++P + SK G ++ S+
Sbjct: 817 YDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSS 876
Query: 114 DDFMCKK-----AASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDY 168
DD K+ ++++ + +T L KK + + T K + L+
Sbjct: 877 DDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEV 936
Query: 169 FGTGSVQRSNKKMVASKRKELSQNTDESGLND--EAIAKQLQLDEDAELER--------Q 218
+ +K + K++ + GL+D E K+ Q DE +E ++ +
Sbjct: 937 RKVAETKEKSKHLKTKTCKKV-----QDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEE 991
Query: 219 LHEDEEFARTLAMLDE--EPKTKKARKDTEAGET------FSSVQANLSKAEKHKYPHKV 270
+ +F + + +++ E + K E E ++ + EK +
Sbjct: 992 KKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRD 1051
Query: 271 KTAQVSDERKSYSPRKQSKYESSKESQQ---------HSKSSADKIGEVSSPK---ASSK 318
KT++ DE Y+ + K +S S+ K +G+ S + +SS
Sbjct: 1052 KTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSD 1111
Query: 319 LAIMKRKEE---SSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPEDSEKK 375
KE+ SS K ++ + + + N + K TK + SS +ES +K+
Sbjct: 1112 TEKYSMKEDGCNSSDKRLKRIELRERRN-LSSKRNTKEIQSGSSSSDAEESSEDNKKKKQ 1170
Query: 376 RTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGG 435
RT+ + + + +L + K A+ + + IE D+ S+ E G
Sbjct: 1171 RTSSKKKAVIVKEKKRNSLRTSTKRKQAD--------ITSSSSSDIEDDDQNSIGE--GS 1220
Query: 436 KVTGNVSKKTNYLVMGRDSG--QSKSDKAAALGTKI-IDEDGLLNLIRTMPGKKSKY-EI 491
+ T LV+ +G QS D+A + + +D+D N KK EI
Sbjct: 1221 SDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEI 1280
Query: 492 AVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIKKETDVFWK 551
++ + P++ + K + E K++ S+ DS ++ KK +
Sbjct: 1281 KANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPR-YRHR 1339
Query: 552 SLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKL 611
L K V++ SG+ K K KP K + G
Sbjct: 1340 LLRHKLTVSDGESGEEK--------------------KTKPKEHKEVKG----------- 1368
Query: 612 LRWLRNWQKSSSEDKKHAKF 631
RN +K SSED + + F
Sbjct: 1369 ----RNRRKVSSEDSEDSDF 1384
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.342
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,147,610
Number of Sequences: 37866
Number of extensions: 1896345
Number of successful extensions: 13770
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 119
Number of HSP's successfully gapped in prelim test: 739
Number of HSP's that attempted gapping in prelim test: 9365
Number of HSP's gapped (non-prelim): 4262
length of query: 1147
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1034
effective length of database: 13,968,660
effective search space: 14443594440
effective search space used: 14443594440
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.