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Search of human proteins with 32455248
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1
(alpha) isoform 1 [Homo sapiens]
(724 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 1459 0.0
gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 858 0.0
gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 853 0.0
gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta... 847 0.0
gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 687 0.0
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 687 0.0
gi|156119615 myosin IXA [Homo sapiens] 84 4e-16
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa... 77 7e-14
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa... 77 7e-14
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 77 7e-14
gi|194272142 myosin IXB isoform 2 [Homo sapiens] 72 1e-12
gi|33356170 myosin IXB isoform 1 [Homo sapiens] 72 1e-12
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 71 4e-12
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 71 4e-12
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 70 5e-12
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 70 5e-12
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 70 7e-12
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 70 9e-12
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 70 9e-12
gi|188497642 ARHGAP15 [Homo sapiens] 69 2e-11
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 66 1e-10
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 66 1e-10
gi|54860079 nadrin isoform 1 [Homo sapiens] 64 4e-10
gi|54860105 nadrin isoform 2 [Homo sapiens] 64 4e-10
gi|91208437 GEM interacting protein [Homo sapiens] 64 5e-10
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 62 1e-09
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 61 3e-09
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 61 3e-09
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens] 60 5e-09
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ... 60 9e-09
>gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 1 [Homo sapiens]
Length = 724
Score = 1459 bits (3778), Expect = 0.0
Identities = 724/724 (100%), Positives = 724/724 (100%)
Query: 1 MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN 60
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
Sbjct: 1 MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN 60
Query: 61 ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE 120
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
Sbjct: 61 ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE 120
Query: 121 QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH 180
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH
Sbjct: 121 QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH 180
Query: 181 VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL 240
VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
Sbjct: 181 VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL 240
Query: 241 QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE 300
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
Sbjct: 241 QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE 300
Query: 301 RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA 360
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
Sbjct: 301 RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA 360
Query: 361 STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL 420
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL
Sbjct: 361 STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL 420
Query: 421 DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK 480
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
Sbjct: 421 DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK 480
Query: 481 RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID 540
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
Sbjct: 481 RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID 540
Query: 541 SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN 600
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
Sbjct: 541 SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN 600
Query: 601 ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS 660
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
Sbjct: 601 ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS 660
Query: 661 VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA 720
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
Sbjct: 661 VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA 720
Query: 721 QQRR 724
QQRR
Sbjct: 721 QQRR 724
>gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 2 [Homo sapiens]
Length = 454
Score = 858 bits (2216), Expect = 0.0
Identities = 420/420 (100%), Positives = 420/420 (100%)
Query: 305 PALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKM 364
PALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKM
Sbjct: 35 PALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKM 94
Query: 365 HGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKL 424
HGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKL
Sbjct: 95 HGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKL 154
Query: 425 LYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAI 484
LYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAI
Sbjct: 155 LYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAI 214
Query: 485 EAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRR 544
EAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRR
Sbjct: 215 EAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRR 274
Query: 545 LEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTE 604
LEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTE
Sbjct: 275 LEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTE 334
Query: 605 DQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVD 664
DQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVD
Sbjct: 335 DQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVD 394
Query: 665 GEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR 724
GEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
Sbjct: 395 GEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR 454
>gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 3 [Homo sapiens]
Length = 424
Score = 853 bits (2205), Expect = 0.0
Identities = 418/418 (100%), Positives = 418/418 (100%)
Query: 307 LPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHG 366
LPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHG
Sbjct: 7 LPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHG 66
Query: 367 DYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLY 426
DYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLY
Sbjct: 67 DYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLY 126
Query: 427 PVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEA 486
PVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEA
Sbjct: 127 PVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEA 186
Query: 487 FNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLE 546
FNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLE
Sbjct: 187 FNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLE 246
Query: 547 EDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQ 606
EDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQ
Sbjct: 247 EDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQ 306
Query: 607 YSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGE 666
YSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGE
Sbjct: 307 YSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGE 366
Query: 667 VKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR 724
VKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
Sbjct: 367 VKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR 424
>gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
[Homo sapiens]
Length = 728
Score = 847 bits (2189), Expect = 0.0
Identities = 436/735 (59%), Positives = 545/735 (74%), Gaps = 39/735 (5%)
Query: 4 EGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNETT 63
EG+QYRALY +++ER ED++L GD+L V++ +L ALG ++G E P+ +GW+ G NE T
Sbjct: 5 EGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERT 64
Query: 64 GERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAEQFA 123
+RGDFPGTYVE++G ++ P P+PR PRPLP P E LTLPDL EQF+
Sbjct: 65 RQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEP-----GLTLPDLPEQFS 119
Query: 124 PPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVHVLA 183
PPD+APPLL+KLVEAIE+ GL+ + YR + + D D++ D LA
Sbjct: 120 PPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRT--------DWSLSDVDQWDTAALA 171
Query: 184 DAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYL 243
D K +LL LP P++ +E E + + P++P LTL++L
Sbjct: 172 DGIKSFLLALPAPLVTPEASAEARRALREAAGP------VGPALEPPTLPLHRALTLRFL 225
Query: 244 LKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASS--------DNTENL----IKVIE 291
L+H ++++ + R L F P+L R S D +E ++E
Sbjct: 226 LQHLGRVARRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVE 285
Query: 292 ILISTEWNERQPAP-ALPPKPPK----PTTVANNGMNNNMSLQDAEWYWGDISREEVNEK 346
L+ E++ AP ALPPKPPK PT +AN G + SLQDAEWYWGDISREEVNEK
Sbjct: 286 KLLQEHLEEQEVAPPALPPKPPKAKPAPTVLANGG--SPPSLQDAEWYWGDISREEVNEK 343
Query: 347 LRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELIN 406
LRDT DGTFLVRDAS+K+ G+YTLTLRKGGNNKLIK+FHRDG YGFS+PLTF SVV+LIN
Sbjct: 344 LRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLIN 403
Query: 407 HYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRL 466
HYR+ESLAQYN KLD +LLYPVSKYQQDQ+VKED++EAVG +L Y+ Q+Q+KSREYD+L
Sbjct: 404 HYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQL 463
Query: 467 YEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMH 526
YEEYTRTSQE+QMKRTAIEAFNETIKIFEEQ QTQE+ SKEY+E+F+REGNEKE+QRI+
Sbjct: 464 YEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILL 523
Query: 527 NYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQ 586
N ++LKSRI+EI +SR +LE+ L+ QA++ REIDKRMNS+KPDL+QLRK RDQYL+WLTQ
Sbjct: 524 NSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQ 583
Query: 587 KGVRQKKLNEWLGNEN-TEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGT 645
KG RQKK+NEWLG +N TEDQY+L+ED++DLPHH+E+TW VG NR +AE +L GKRDGT
Sbjct: 584 KGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGT 643
Query: 646 FLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQ 705
FL+RESS++GCYACSVVVDG+ KHCVI +TATG+GFAEPYNLY SLKELVLHYQH SLVQ
Sbjct: 644 FLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQ 703
Query: 706 HNDSLNVTLAYPVYA 720
HND+L VTLA+PV A
Sbjct: 704 HNDALTVTLAHPVRA 718
Score = 64.3 bits (155), Expect = 4e-10
Identities = 39/109 (35%), Positives = 56/109 (51%), Gaps = 3/109 (2%)
Query: 617 PHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSK--QGCYACSVVVDGEVKHCVINK 674
P + W G +R + LR DGTFLVR++S QG Y ++ G K +
Sbjct: 323 PSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH 382
Query: 675 TATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR 723
YGF+EP + S+ +L+ HY+H SL Q+N L+ L YPV Q+
Sbjct: 383 RDGHYGFSEPLT-FCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQ 430
>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 687 bits (1772), Expect = 0.0
Identities = 338/421 (80%), Positives = 379/421 (90%), Gaps = 4/421 (0%)
Query: 305 PALPPKPPKPTTVA-NNGM-NNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDAST 362
PALPPKPPKP T A NGM ++++SLQDAEWYWGDISREEVN+KLRD DGTFLVRDAST
Sbjct: 35 PALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDAST 94
Query: 363 KMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDV 422
KM GDYTLTLRKGGNNKLIKI+HRDGKYGFSDPLTF+SVVELINHY +ESLAQYNPKLDV
Sbjct: 95 KMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDV 154
Query: 423 KLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRT 482
KL+YPVS+YQQDQ+VKEDNI+AVGKKL EY++Q+QEKS+EYDRLYEEYTRTSQEIQMKRT
Sbjct: 155 KLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRT 214
Query: 483 AIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSR 542
AIEAFNETIKIFEEQC TQE++SKEYIE+F+REGNEKEI+RIM NYDKLKSR+ EI DS+
Sbjct: 215 AIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSK 274
Query: 543 RRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG--N 600
RLE+DLK QA + REIDK+MNSIKPDLIQLRK RDQ+L+WL KGVRQK+LN WLG N
Sbjct: 275 MRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKN 334
Query: 601 ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS 660
E+ ++ Y + E+DE+LPH+DEKTW V NR +AE+LL GK DG FL+RESSK+GCYACS
Sbjct: 335 EDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACS 394
Query: 661 VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA 720
VV DGEVKHCVI TA GYGFAEPYNLYSSLKELVLHYQ TSLVQHNDSLNV LAYPV+A
Sbjct: 395 VVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHA 454
Query: 721 Q 721
Q
Sbjct: 455 Q 455
Score = 66.6 bits (161), Expect = 8e-11
Identities = 40/102 (39%), Positives = 56/102 (54%), Gaps = 3/102 (2%)
Query: 624 WNVGSSNRNKAENLLRGKRDGTFLVRESSK--QGCYACSVVVDGEVKHCVINKTATGYGF 681
W G +R + + LR DGTFLVR++S QG Y ++ G K I YGF
Sbjct: 65 WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF 124
Query: 682 AEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR 723
++P ++S+ EL+ HY H SL Q+N L+V L YPV Q+
Sbjct: 125 SDPLT-FNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQ 165
>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 687 bits (1772), Expect = 0.0
Identities = 338/421 (80%), Positives = 379/421 (90%), Gaps = 4/421 (0%)
Query: 305 PALPPKPPKPTTVA-NNGM-NNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDAST 362
PALPPKPPKP T A NGM ++++SLQDAEWYWGDISREEVN+KLRD DGTFLVRDAST
Sbjct: 35 PALPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDAST 94
Query: 363 KMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDV 422
KM GDYTLTLRKGGNNKLIKI+HRDGKYGFSDPLTF+SVVELINHY +ESLAQYNPKLDV
Sbjct: 95 KMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDV 154
Query: 423 KLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRT 482
KL+YPVS+YQQDQ+VKEDNI+AVGKKL EY++Q+QEKS+EYDRLYEEYTRTSQEIQMKRT
Sbjct: 155 KLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRT 214
Query: 483 AIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSR 542
AIEAFNETIKIFEEQC TQE++SKEYIE+F+REGNEKEI+RIM NYDKLKSR+ EI DS+
Sbjct: 215 AIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSK 274
Query: 543 RRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG--N 600
RLE+DLK QA + REIDK+MNSIKPDLIQLRK RDQ+L+WL KGVRQK+LN WLG N
Sbjct: 275 MRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKN 334
Query: 601 ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS 660
E+ ++ Y + E+DE+LPH+DEKTW V NR +AE+LL GK DG FL+RESSK+GCYACS
Sbjct: 335 EDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACS 394
Query: 661 VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA 720
VV DGEVKHCVI TA GYGFAEPYNLYSSLKELVLHYQ TSLVQHNDSLNV LAYPV+A
Sbjct: 395 VVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHA 454
Query: 721 Q 721
Q
Sbjct: 455 Q 455
Score = 66.6 bits (161), Expect = 8e-11
Identities = 40/102 (39%), Positives = 56/102 (54%), Gaps = 3/102 (2%)
Query: 624 WNVGSSNRNKAENLLRGKRDGTFLVRESSK--QGCYACSVVVDGEVKHCVINKTATGYGF 681
W G +R + + LR DGTFLVR++S QG Y ++ G K I YGF
Sbjct: 65 WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF 124
Query: 682 AEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR 723
++P ++S+ EL+ HY H SL Q+N L+V L YPV Q+
Sbjct: 125 SDPLT-FNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQ 165
>gi|156119615 myosin IXA [Homo sapiens]
Length = 2548
Score = 84.3 bits (207), Expect = 4e-16
Identities = 64/199 (32%), Positives = 101/199 (50%), Gaps = 16/199 (8%)
Query: 99 PGSSKTEADVEQQALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSN- 157
P S + VE LT D P ++ KL+ IE GL +YR S+N
Sbjct: 2054 PELSSRQFGVELSRLTSEDRT--------VPLVVEKLINYIEMHGLYTEGIYRKSGSTNK 2105
Query: 158 LAELRQLLDCDTPSVDLEMIDVHVLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSE 217
+ ELRQ LD D SV+L+ ++HV+A FK++L DLPNP++ +Y E + A +Q +
Sbjct: 2106 IKELRQGLDTDAESVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLR-AMGLQERK 2164
Query: 218 EYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSA 277
E I+ + +I S H TL+ L+ H +++ N ++A L+ +F+P + R
Sbjct: 2165 ETIRGVYSVIDQLSRTHLN--TLERLIFHLVRIALQEDTNRMSANALAIVFAPCILR--- 2219
Query: 278 ASSDNTENLIKVIEILIST 296
D T+ L V +I +T
Sbjct: 2220 -CPDTTDPLQSVQDISKTT 2237
>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
sapiens]
Length = 653
Score = 76.6 bits (187), Expect = 7e-14
Identities = 59/206 (28%), Positives = 103/206 (50%), Gaps = 9/206 (4%)
Query: 127 IAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLA-ELRQLLDC-DTPSVDLEMIDVHVLAD 184
+AP L+ + V+ I ++GL+ L+R +NL EL+ DC + PS D DVH +A
Sbjct: 56 LAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNT-DVHTVAS 114
Query: 185 AFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEY-IQLLKKLIRSPSIPHQYWLTLQYL 243
K YL +LP PVIP A Y + +S A + EE ++ L K ++ S+P + L+Y+
Sbjct: 115 LLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVK--SLPVVNYNLLKYI 172
Query: 244 LKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNERQP 303
+ ++ S N ++ + L+ +F P + R V++ L+S ++
Sbjct: 173 CRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHD- 231
Query: 304 APALPPKPPKPTTVANNGMNNNMSLQ 329
L PK + + +G++NN +Q
Sbjct: 232 --CLFPKDAELQSKPQDGVSNNNEIQ 255
>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
sapiens]
Length = 655
Score = 76.6 bits (187), Expect = 7e-14
Identities = 59/206 (28%), Positives = 103/206 (50%), Gaps = 9/206 (4%)
Query: 127 IAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLA-ELRQLLDC-DTPSVDLEMIDVHVLAD 184
+AP L+ + V+ I ++GL+ L+R +NL EL+ DC + PS D DVH +A
Sbjct: 58 LAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNT-DVHTVAS 116
Query: 185 AFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEY-IQLLKKLIRSPSIPHQYWLTLQYL 243
K YL +LP PVIP A Y + +S A + EE ++ L K ++ S+P + L+Y+
Sbjct: 117 LLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVK--SLPVVNYNLLKYI 174
Query: 244 LKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNERQP 303
+ ++ S N ++ + L+ +F P + R V++ L+S ++
Sbjct: 175 CRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHD- 233
Query: 304 APALPPKPPKPTTVANNGMNNNMSLQ 329
L PK + + +G++NN +Q
Sbjct: 234 --CLFPKDAELQSKPQDGVSNNNEIQ 257
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 76.6 bits (187), Expect = 7e-14
Identities = 59/206 (28%), Positives = 103/206 (50%), Gaps = 9/206 (4%)
Query: 127 IAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLA-ELRQLLDC-DTPSVDLEMIDVHVLAD 184
+AP L+ + V+ I ++GL+ L+R +NL EL+ DC + PS D DVH +A
Sbjct: 151 LAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNT-DVHTVAS 209
Query: 185 AFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEY-IQLLKKLIRSPSIPHQYWLTLQYL 243
K YL +LP PVIP A Y + +S A + EE ++ L K ++ S+P + L+Y+
Sbjct: 210 LLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVK--SLPVVNYNLLKYI 267
Query: 244 LKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNERQP 303
+ ++ S N ++ + L+ +F P + R V++ L+S ++
Sbjct: 268 CRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHD- 326
Query: 304 APALPPKPPKPTTVANNGMNNNMSLQ 329
L PK + + +G++NN +Q
Sbjct: 327 --CLFPKDAELQSKPQDGVSNNNEIQ 350
>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
Length = 2022
Score = 72.4 bits (176), Expect = 1e-12
Identities = 48/166 (28%), Positives = 80/166 (48%), Gaps = 8/166 (4%)
Query: 129 PPLLIKLVEAIEKKGLECSTLYRTQSSSNLA-ELRQLLDCDTPSVDLEMIDVHVLADAFK 187
P +L KL+E +E GL LYR ++N ELRQ L D +V LE +H + K
Sbjct: 1713 PIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLK 1772
Query: 188 RYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHF 247
++L +LP P++ A Y + + + E+ + L P H +L+ L+ H
Sbjct: 1773 QWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHN---SLERLIFHL 1829
Query: 248 FKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEIL 293
K++ N ++ L+ IF+P L R DN++ L + ++L
Sbjct: 1830 VKVALLEDVNRMSPGALAIIFAPCLLR----CPDNSDPLTSMKDVL 1871
>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
Length = 2157
Score = 72.4 bits (176), Expect = 1e-12
Identities = 48/166 (28%), Positives = 80/166 (48%), Gaps = 8/166 (4%)
Query: 129 PPLLIKLVEAIEKKGLECSTLYRTQSSSNLA-ELRQLLDCDTPSVDLEMIDVHVLADAFK 187
P +L KL+E +E GL LYR ++N ELRQ L D +V LE +H + K
Sbjct: 1713 PIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLK 1772
Query: 188 RYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHF 247
++L +LP P++ A Y + + + E+ + L P H +L+ L+ H
Sbjct: 1773 QWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHN---SLERLIFHL 1829
Query: 248 FKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEIL 293
K++ N ++ L+ IF+P L R DN++ L + ++L
Sbjct: 1830 VKVALLEDVNRMSPGALAIIFAPCLLR----CPDNSDPLTSMKDVL 1871
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 70.9 bits (172), Expect = 4e-12
Identities = 50/177 (28%), Positives = 89/177 (50%), Gaps = 12/177 (6%)
Query: 130 PLLIKL-VEAIEKKGLECSTLYRTQSSSNLAE-LRQLLDCDTPSVDLEM---IDVHVLAD 184
P+++ + + IE +GL LYR S+L E ++ D D D+ + D++++
Sbjct: 282 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 341
Query: 185 AFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLL 244
A K Y DLP P+I Y + I A ++ +E ++ L + ++ +P + TL+YL+
Sbjct: 342 ALKLYFRDLPIPLITYDAYPKFIESA-KIMDPDEQLETLHEALK--LLPPAHCETLRYLM 398
Query: 245 KHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIK----VIEILISTE 297
H +++ +NL+NA L +F P L R + N I+ V+E+LI E
Sbjct: 399 AHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNE 455
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 70.9 bits (172), Expect = 4e-12
Identities = 50/177 (28%), Positives = 89/177 (50%), Gaps = 12/177 (6%)
Query: 130 PLLIKL-VEAIEKKGLECSTLYRTQSSSNLAE-LRQLLDCDTPSVDLEM---IDVHVLAD 184
P+++ + + IE +GL LYR S+L E ++ D D D+ + D++++
Sbjct: 256 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 315
Query: 185 AFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLL 244
A K Y DLP P+I Y + I A ++ +E ++ L + ++ +P + TL+YL+
Sbjct: 316 ALKLYFRDLPIPLITYDAYPKFIESA-KIMDPDEQLETLHEALK--LLPPAHCETLRYLM 372
Query: 245 KHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIK----VIEILISTE 297
H +++ +NL+NA L +F P L R + N I+ V+E+LI E
Sbjct: 373 AHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNE 429
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 70.5 bits (171), Expect = 5e-12
Identities = 47/177 (26%), Positives = 93/177 (52%), Gaps = 12/177 (6%)
Query: 130 PLLIKL-VEAIEKKGLECSTLYRTQS-SSNLAELRQLLDCDTPSVDLEMI---DVHVLAD 184
P+++ + + IE +GL+ LYR + ++ +++ D D D+ D++++
Sbjct: 291 PMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITG 350
Query: 185 AFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLL 244
A K Y DLP PVI YS+ I A ++ +++E ++ + +++ +P ++ TL+YL+
Sbjct: 351 ALKLYFRDLPIPVITYDTYSKFIDAA-KISNADERLEAVHEVLML--LPPAHYETLRYLM 407
Query: 245 KHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIK----VIEILISTE 297
H K++ N +NA L +F P L R S+ T + ++ +++ILI E
Sbjct: 408 IHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENE 464
Score = 40.8 bits (94), Expect = 0.004
Identities = 44/188 (23%), Positives = 79/188 (42%), Gaps = 19/188 (10%)
Query: 307 LPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHG 366
L + P+P + N + G ISRE+ +E L +G +++R+ S + G
Sbjct: 33 LQQEAPRPKRIICPREVENRPKYYGREFHGIISREQADELLGGV-EGAYILRE-SQRQPG 90
Query: 367 DYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINH-----YRNESLAQYNPKLD 421
YTL LR G ++FH DGK+ F F S+ +L+ Y A+Y K+
Sbjct: 91 CYTLALRFGNQTLNYRLFH-DGKH-FVGEKRFESIHDLVTDGLITLYIETKAAEYISKMT 148
Query: 422 VKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKR 481
+Y Y + +K+ ++ + + R+ + +EE+T + + R
Sbjct: 149 TNPIYEHIGY----------ATLLREKVSRRLSRSKNEPRKTNVTHEEHTAVEKISSLVR 198
Query: 482 TAIEAFNE 489
A N+
Sbjct: 199 RAALTHND 206
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 70.5 bits (171), Expect = 5e-12
Identities = 47/177 (26%), Positives = 93/177 (52%), Gaps = 12/177 (6%)
Query: 130 PLLIKL-VEAIEKKGLECSTLYRTQS-SSNLAELRQLLDCDTPSVDLEMI---DVHVLAD 184
P+++ + + IE +GL+ LYR + ++ +++ D D D+ D++++
Sbjct: 155 PMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITG 214
Query: 185 AFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLL 244
A K Y DLP PVI YS+ I A ++ +++E ++ + +++ +P ++ TL+YL+
Sbjct: 215 ALKLYFRDLPIPVITYDTYSKFIDAA-KISNADERLEAVHEVLML--LPPAHYETLRYLM 271
Query: 245 KHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIK----VIEILISTE 297
H K++ N +NA L +F P L R S+ T + ++ +++ILI E
Sbjct: 272 IHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENE 328
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 70.1 bits (170), Expect = 7e-12
Identities = 53/206 (25%), Positives = 102/206 (49%), Gaps = 21/206 (10%)
Query: 129 PPLLIKLVEAIEKKGLECSTLYRTQSSSNL-AELRQLLDCDTPSVDLE---MIDVHVLAD 184
P ++ +E +GLE + +YR ++ + + L++ L+ ++L+ D++V++
Sbjct: 826 PLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISS 885
Query: 185 AFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLL 244
K + LP P+ Y++ I A ++ + E ++ L+KLIR +P Y+ TL++L+
Sbjct: 886 LLKSFFRKLPEPLFTDDKYNDFIE-ANRIEDARERMRTLRKLIRD--LPGHYYETLKFLV 942
Query: 245 KHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLI-------KVIEILIS-T 296
H ++ S KN + R L+ +F P L R S DN +++ K++E LI +
Sbjct: 943 GHLKTIADHSEKNKMEPRNLALVFGPTLVR---TSEDNMTDMVTHMPDRYKIVETLIQHS 999
Query: 297 EW---NERQPAPALPPKPPKPTTVAN 319
+W +E P +P V N
Sbjct: 1000 DWFFSDEEDKGERTPVGDKEPQAVPN 1025
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 69.7 bits (169), Expect = 9e-12
Identities = 59/222 (26%), Positives = 103/222 (46%), Gaps = 21/222 (9%)
Query: 79 RKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAEQFAPPDIAPPLLIKLVEA 138
R+ P PKPRP S T+A E +P L P P + + +E
Sbjct: 1223 RRNTKKPKPKPRP----------SITKATWESNYFGVP-LTTVVTPEKPIPIFIERCIEY 1271
Query: 139 IEKKGLECSTLYRTQSS-SNLAELRQLLDCDTPSVDLEMID--VHVLADAFKRYLLDLPN 195
IE GL +YR + S + L++ D D ++DL D V+ +A A K + +LP+
Sbjct: 1272 IEATGLSTEGIYRVSGNKSEMESLQRQFDQDH-NLDLAEKDFTVNTVAGAMKSFFSELPD 1330
Query: 196 PVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSS 255
P++P + +++ A ++ E+ + LK++++ P + +Y++ H K+S +
Sbjct: 1331 PLVPYNMQIDLVE-AHKINDREQKLHALKEVLK--KFPKENHEVFKYVISHLNKVSHNNK 1387
Query: 256 KNLLNARVLSEIFSPMLFRFSAASSD---NTENLIKVIEILI 294
NL+ + LS F P L R ++ D T +IE+ I
Sbjct: 1388 VNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFI 1429
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 69.7 bits (169), Expect = 9e-12
Identities = 43/151 (28%), Positives = 79/151 (52%), Gaps = 2/151 (1%)
Query: 125 PDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLA-ELRQLLDCDTPSVDLEMIDVHVLA 183
P +AP L+ + V+ I ++GL L+R +NL +L+ DC + DVH +A
Sbjct: 169 PRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVA 228
Query: 184 DAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYL 243
K YL +LP PV+P A Y + +S A ++ + +E L+ + ++P + L+Y+
Sbjct: 229 SLLKLYLRELPEPVVPFARYEDFLSCA-QLLTKDEGEGTLELAKQVSNLPQANYNLLRYI 287
Query: 244 LKHFFKLSQTSSKNLLNARVLSEIFSPMLFR 274
K ++ S+ N ++ + L+ +F P + R
Sbjct: 288 CKFLDEVQAYSNVNKMSVQNLATVFGPNILR 318
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 68.9 bits (167), Expect = 2e-11
Identities = 47/179 (26%), Positives = 94/179 (52%), Gaps = 21/179 (11%)
Query: 129 PPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQL---------LDCDTPSVDLEMIDV 179
P + + +EA+EK+GL+ +YR S NLA +++L L+ D D + D+
Sbjct: 295 PWFVKQCIEAVEKRGLDVDGIYRV--SGNLATIQKLRFIVNQEEKLNLD----DSQWEDI 348
Query: 180 HVLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLT 239
HV+ A K + +LP P+ P + + + + A + Q + I+ +K L++ P++ T
Sbjct: 349 HVVTGALKMFFRELPEPLFPYSFFEQFVE-AIKKQDNNTRIEAVKSLVQKLPPPNRD--T 405
Query: 240 LQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLI---KVIEILIS 295
++ L H K+ +SKNL++ + L +F P L R + + +++ ++ E+++S
Sbjct: 406 MKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLS 464
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
sapiens]
Length = 731
Score = 65.9 bits (159), Expect = 1e-10
Identities = 52/183 (28%), Positives = 84/183 (45%), Gaps = 36/183 (19%)
Query: 126 DIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQL--------------------- 164
D P L + A++K+GL+ +YR S NLA +++L
Sbjct: 534 DTVPSFLRLCIAAVDKRGLDVDGIYRV--SGNLAVVQKLRFLVDRERAVTSDGRYVFPEQ 591
Query: 165 ------LDCDTPSVDLEMIDVHVLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEE 218
LD D+ D D+HV+ A K +L +LP P++P + + A + SE+
Sbjct: 592 PGQEGRLDLDSTEWD----DIHVVTGALKLFLRELPQPLVPPLLLPHFRA-ALALSESEQ 646
Query: 219 YIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAA 278
+ +++LI S P+ TL+YLL+H ++ S KN + L +F P LFR
Sbjct: 647 CLSQIQELIGSMPKPNHD--TLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQE 704
Query: 279 SSD 281
+SD
Sbjct: 705 TSD 707
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
sapiens]
Length = 547
Score = 65.9 bits (159), Expect = 1e-10
Identities = 52/183 (28%), Positives = 84/183 (45%), Gaps = 36/183 (19%)
Query: 126 DIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQL--------------------- 164
D P L + A++K+GL+ +YR S NLA +++L
Sbjct: 350 DTVPSFLRLCIAAVDKRGLDVDGIYRV--SGNLAVVQKLRFLVDRERAVTSDGRYVFPEQ 407
Query: 165 ------LDCDTPSVDLEMIDVHVLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEE 218
LD D+ D D+HV+ A K +L +LP P++P + + A + SE+
Sbjct: 408 PGQEGRLDLDSTEWD----DIHVVTGALKLFLRELPQPLVPPLLLPHFRA-ALALSESEQ 462
Query: 219 YIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAA 278
+ +++LI S P+ TL+YLL+H ++ S KN + L +F P LFR
Sbjct: 463 CLSQIQELIGSMPKPNHD--TLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQE 520
Query: 279 SSD 281
+SD
Sbjct: 521 TSD 523
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 64.3 bits (155), Expect = 4e-10
Identities = 50/181 (27%), Positives = 93/181 (51%), Gaps = 12/181 (6%)
Query: 126 DIAPPLLIKLVEAIEKKGLECSTLYRTQS-SSNLAELRQLLDCDTPSVDLEMIDVHVLAD 184
+IA P+ ++ +E G++ L+R + +S L +L+ LDC T +D D H +A
Sbjct: 264 EIALPIEACVMLLLET-GMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAG 322
Query: 185 AFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLL 244
A K YL +LP P++ +Y E +A VQ ++ +Q L + + +P Q ++ +YL+
Sbjct: 323 ALKSYLRELPEPLMTFNLYEEWTQVA-SVQDQDKKLQDLWRTCQ--KLPPQNFVNFRYLI 379
Query: 245 KHFFKLSQTSSKNLLNARVLSEIFSPMLF------RFSAASSDNTENLIKVIEILIS-TE 297
K KL+QTS N + ++ + P L + ++ + +++ VIE +I +
Sbjct: 380 KFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQHAD 439
Query: 298 W 298
W
Sbjct: 440 W 440
>gi|54860105 nadrin isoform 2 [Homo sapiens]
Length = 803
Score = 64.3 bits (155), Expect = 4e-10
Identities = 50/181 (27%), Positives = 93/181 (51%), Gaps = 12/181 (6%)
Query: 126 DIAPPLLIKLVEAIEKKGLECSTLYRTQS-SSNLAELRQLLDCDTPSVDLEMIDVHVLAD 184
+IA P+ ++ +E G++ L+R + +S L +L+ LDC T +D D H +A
Sbjct: 264 EIALPIEACVMLLLET-GMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAG 322
Query: 185 AFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLL 244
A K YL +LP P++ +Y E +A VQ ++ +Q L + + +P Q ++ +YL+
Sbjct: 323 ALKSYLRELPEPLMTFNLYEEWTQVA-SVQDQDKKLQDLWRTCQ--KLPPQNFVNFRYLI 379
Query: 245 KHFFKLSQTSSKNLLNARVLSEIFSPMLF------RFSAASSDNTENLIKVIEILIS-TE 297
K KL+QTS N + ++ + P L + ++ + +++ VIE +I +
Sbjct: 380 KFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQHAD 439
Query: 298 W 298
W
Sbjct: 440 W 440
>gi|91208437 GEM interacting protein [Homo sapiens]
Length = 970
Score = 63.9 bits (154), Expect = 5e-10
Identities = 47/162 (29%), Positives = 76/162 (46%), Gaps = 14/162 (8%)
Query: 125 PDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAE-LRQLLDCDTPSVDLEMIDVHVLA 183
P+ P ++ K IE + L+ +YR S E L Q + V+L H ++
Sbjct: 561 PEEVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRALVELSGNSPHDVS 620
Query: 184 DAFKRYLLDLPNPVIPAAVYSEMISLAPEVQS-----------SEEYIQLLKKLIRSPSI 232
KR+L +L PVIP +Y ISLA + + S E I+ LK L+ +
Sbjct: 621 SVLKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGTPSPSPEVIRSLKTLL--VQL 678
Query: 233 PHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFR 274
P + TL++L+ H F+++ +N ++A L +F P L R
Sbjct: 679 PDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLR 720
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 62.4 bits (150), Expect = 1e-09
Identities = 44/177 (24%), Positives = 94/177 (53%), Gaps = 18/177 (10%)
Query: 130 PLLIKLV-EAIEKKGLECSTLYRTQ-SSSNLAELRQLLDCDTPSVDLE---MIDVHVLAD 184
PL++ + + +E++GLE + +YR +++ ++ +++ L+ +D++ D++V++
Sbjct: 1162 PLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISS 1221
Query: 185 AFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLL 244
K + LP P+ Y++ I A + + ++ LK+LI +P ++ TL++L
Sbjct: 1222 LLKSFFRKLPEPLFTNDKYADFIE-ANRKEDPLDRLKTLKRLIHD--LPEHHYETLKFLS 1278
Query: 245 KHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLI-------KVIEILI 294
H +++ S KN + R L+ +F P L R S DN +++ K++E LI
Sbjct: 1279 AHLKTVAENSEKNKMEPRNLAIVFGPTLVR---TSEDNMTHMVTHMPDQYKIVETLI 1332
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 61.2 bits (147), Expect = 3e-09
Identities = 49/193 (25%), Positives = 94/193 (48%), Gaps = 27/193 (13%)
Query: 129 PPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQL---------LDCDTPSVDLEMIDV 179
P + + + A+E +GL+ LYR S NLA +++L LD D D DV
Sbjct: 343 PRFVQQCIRAVEARGLDIDGLYRI--SGNLATIQKLRYKVDHDERLDLD----DGRWEDV 396
Query: 180 HVLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLT 239
HV+ A K + +LP P+ P + + + I+ A ++Q + ++ L+RS P+ T
Sbjct: 397 HVITGALKLFFRELPEPLFPFSHFRQFIA-AIKLQDQARRSRCVRDLVRSLPAPNHD--T 453
Query: 240 LQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLI---KVIEILIST 296
L+ L +H ++ + +N ++ + ++ +F P L R + ++ +V+E+++
Sbjct: 454 LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELIL-- 511
Query: 297 EWNERQPAPALPP 309
+Q A PP
Sbjct: 512 ----QQCADIFPP 520
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 61.2 bits (147), Expect = 3e-09
Identities = 49/193 (25%), Positives = 94/193 (48%), Gaps = 27/193 (13%)
Query: 129 PPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQL---------LDCDTPSVDLEMIDV 179
P + + + A+E +GL+ LYR S NLA +++L LD D D DV
Sbjct: 370 PRFVQQCIRAVEARGLDIDGLYRI--SGNLATIQKLRYKVDHDERLDLD----DGRWEDV 423
Query: 180 HVLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLT 239
HV+ A K + +LP P+ P + + + I+ A ++Q + ++ L+RS P+ T
Sbjct: 424 HVITGALKLFFRELPEPLFPFSHFRQFIA-AIKLQDQARRSRCVRDLVRSLPAPNHD--T 480
Query: 240 LQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLI---KVIEILIST 296
L+ L +H ++ + +N ++ + ++ +F P L R + ++ +V+E+++
Sbjct: 481 LRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELIL-- 538
Query: 297 EWNERQPAPALPP 309
+Q A PP
Sbjct: 539 ----QQCADIFPP 547
>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
Length = 1444
Score = 60.5 bits (145), Expect = 5e-09
Identities = 44/152 (28%), Positives = 78/152 (51%), Gaps = 12/152 (7%)
Query: 129 PPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDT-PSVDLEMI--DVHVLADA 185
P +L E IE G+ + +SN+ LRQ D P + E+ D+H +
Sbjct: 35 PYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSL 94
Query: 186 FKRYLLDLPNPVIPAAVY---SEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQY 242
K Y +LPNP++ +Y +E +S PE E + ++ +I+ +P ++ TL+Y
Sbjct: 95 CKLYFRELPNPLLTYELYEKFTEAVSHCPE----EGQLARIQNVIQE--LPPSHYRTLEY 148
Query: 243 LLKHFFKLSQTSSKNLLNARVLSEIFSPMLFR 274
L++H ++ SSK ++AR L+ +++P L R
Sbjct: 149 LIRHLAHIASFSSKTNMHARNLALVWAPNLLR 180
>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 287
Score = 59.7 bits (143), Expect = 9e-09
Identities = 39/125 (31%), Positives = 64/125 (51%), Gaps = 10/125 (8%)
Query: 303 PAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDAST 362
P+ A+ P P P V + S Q WY G + R + +L + + T+LVR T
Sbjct: 91 PSDAVKPCPCVPKPV-------DYSCQP--WYAGAMERLQAETELINRVNSTYLVRHR-T 140
Query: 363 KMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDV 422
K G+Y ++++ K IKI RDG + ++ F S++EL+ +Y++ SL + LD
Sbjct: 141 KESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDT 200
Query: 423 KLLYP 427
L +P
Sbjct: 201 TLQFP 205
Score = 52.8 bits (125), Expect = 1e-06
Identities = 34/95 (35%), Positives = 51/95 (53%), Gaps = 2/95 (2%)
Query: 624 WNVGSSNRNKAENLLRGKRDGTFLVRESSKQ-GCYACSVVVDGEVKHCVINKTATGYGFA 682
W G+ R +AE L + + T+LVR +K+ G YA S+ + E KH I T G+
Sbjct: 112 WYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKI-LTRDGFFHI 170
Query: 683 EPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYP 717
+ SL ELV +Y+H SL + +L+ TL +P
Sbjct: 171 AENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFP 205
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,571,004
Number of Sequences: 37866
Number of extensions: 1442707
Number of successful extensions: 11077
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 184
Number of HSP's successfully gapped in prelim test: 642
Number of HSP's that attempted gapping in prelim test: 8944
Number of HSP's gapped (non-prelim): 2314
length of query: 724
length of database: 18,247,518
effective HSP length: 110
effective length of query: 614
effective length of database: 14,082,258
effective search space: 8646506412
effective search space used: 8646506412
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.