Search of human proteins with 32189398

Search of human proteins with 32189398

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32189398 gastric intrinsic factor (vitamin B synthesis)
precursor [Homo sapiens]
         (417 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32189398 gastric intrinsic factor (vitamin B synthesis) precu...   830   0.0  
gi|21071008 transcobalamin I precursor [Homo sapiens]                 185   6e-47
gi|21071010 transcobalamin II precursor [Homo sapiens]                102   8e-22
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat...    32   0.82 
gi|55741864 zinc finger, FYVE domain containing 28 [Homo sapiens]      32   1.1  
gi|71725360 zinc finger protein 609 [Homo sapiens]                     31   1.8  
gi|38201621 eukaryotic translation initiation factor 4 gamma, 1 ...    30   4.1  
gi|38201627 eukaryotic translation initiation factor 4 gamma, 1 ...    30   4.1  
gi|38201625 eukaryotic translation initiation factor 4 gamma, 1 ...    30   4.1  
gi|38201623 eukaryotic translation initiation factor 4 gamma, 1 ...    30   4.1  
gi|38201619 eukaryotic translation initiation factor 4 gamma, 1 ...    30   4.1  
gi|239754626 PREDICTED: hypothetical protein [Homo sapiens]            30   5.3  
gi|66730481 neuregulin 3 [Homo sapiens]                                29   6.9  
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]      29   6.9  
gi|19913406 DNA topoisomerase II, alpha isozyme [Homo sapiens]         29   9.0  

>gi|32189398 gastric intrinsic factor (vitamin B synthesis)
           precursor [Homo sapiens]
          Length = 417

 Score =  830 bits (2144), Expect = 0.0
 Identities = 417/417 (100%), Positives = 417/417 (100%)

Query: 1   MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIA 60
           MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIA
Sbjct: 1   MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIA 60

Query: 61  MNLAGAYNLKAQKLLTYQLMSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENW 120
           MNLAGAYNLKAQKLLTYQLMSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENW
Sbjct: 61  MNLAGAYNLKAQKLLTYQLMSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENW 120

Query: 121 APSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGAMATLAL 180
           APSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGAMATLAL
Sbjct: 121 APSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGAMATLAL 180

Query: 181 TCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPS 240
           TCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPS
Sbjct: 181 TCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPS 240

Query: 241 KKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQVTCSPDHEVQPTLPS 300
           KKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQVTCSPDHEVQPTLPS
Sbjct: 241 KKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQVTCSPDHEVQPTLPS 300

Query: 301 NPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFE 360
           NPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFE
Sbjct: 301 NPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFE 360

Query: 361 TTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY 417
           TTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY
Sbjct: 361 TTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY 417


>gi|21071008 transcobalamin I precursor [Homo sapiens]
          Length = 433

 Score =  185 bits (470), Expect = 6e-47
 Identities = 136/412 (33%), Positives = 217/412 (52%), Gaps = 42/412 (10%)

Query: 33  EPLVNGIQVLMENSVTSSAYPNPSILIAMNLAGAYNLKAQKLLTYQL---MSSDNNDLTI 89
           +PL+N +     N  TS+     ++++++ L G       + +  Q+   + S  +D++ 
Sbjct: 37  KPLLNTMIQSNYNRGTSAV----NVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSS 92

Query: 90  GQLGLTIMALTSSCRDPGDKV----SILQRQMENWAPSSPNAEA------SAFYGPSLAI 139
           G+L L I+AL   CR+  + +     ++ +    +     N EA      + +Y  SL +
Sbjct: 93  GELALIILAL-GVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDV 151

Query: 140 LALCQKNSEATLPIAVRFAKTLLAN---SSPFNVDTGAMATLALTCMYNKIPVG---SEE 193
           LALC  N   +    V        N    S F+VDTGAMA LALTC+   +  G   ++E
Sbjct: 152 LALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADE 211

Query: 194 GYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEP-SKKEWNCKKTTDM 252
           G         K +VEKI  + K+NG+IG+ +STG AMQAL V+ +  ++ +WNC++T + 
Sbjct: 212 GSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNT 271

Query: 253 ILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQ----VTCSPDHEVQPTLPSNPGPGPTS 308
           +L EI QG F NP + AQ+LP+L GKT+LD+ +    V+ S +  +    P    P P S
Sbjct: 272 VLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTP-PDS 330

Query: 309 ASNITVIYTINNQLRGVELLFNET--INVSVKSGSVLLVVLEEAQRKN-PMFKFETTMTS 365
            S I+V Y++           NET   NV+V +GSV L V+E+AQ+ N  +F F     S
Sbjct: 331 QSYISVNYSVR---------INETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERS 381

Query: 366 WGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY 417
           WG  ++ I  +  N N +TYW+ LSG  PL++G   Y+  N E++   +++Y
Sbjct: 382 WGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVVRNGENLEVRWSKY 433


>gi|21071010 transcobalamin II precursor [Homo sapiens]
          Length = 427

 Score =  102 bits (253), Expect = 8e-22
 Identities = 118/440 (26%), Positives = 188/440 (42%), Gaps = 62/440 (14%)

Query: 6   LYLLSLLWATAGTSTQTQSSCSVPSAQEPLVN--GIQVLMENSVTSSAYPNPSILIAMNL 63
           L+LL +L A           C +P     LV   G  +L      S  + NPSI + + L
Sbjct: 8   LFLLGVLGALT-------EMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRL 60

Query: 64  AG------------AYNLKAQKLLTYQLMSSDNNDL----TIGQLGLTIMALTSSCRDP- 106
           +             +  L  Q+ L     S D+ D     ++GQL L ++AL ++C    
Sbjct: 61  SSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVR 120

Query: 107 GDKVSILQRQMENWAPSSPNAEA--------SAFYGPSLAILALCQKNSEATLPIAVRFA 158
           G K   L  Q++ +      A          +++Y   L ILALC         +  +  
Sbjct: 121 GHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDK-- 178

Query: 159 KTLLANSSPFN-----VDTGAMATLALTCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMK 213
             LL    PF+     VDT AMA LA TC+          G R      ++ + E+I   
Sbjct: 179 --LLYAVEPFHQGHHSVDTAAMAGLAFTCLKRS---NFNPGRRQRITMAIRTVREEILKA 233

Query: 214 IKDNGIIGDIYSTGLAMQALSVTP-EPSKKEWNCKKTTDMILNEIKQGKFHNPMSIAQIL 272
               G  G++YST LA+Q L  +P   ++    C K    +L  ++ G F N + I+Q+L
Sbjct: 234 QTPEGHFGNVYSTPLALQFLMTSPMRGAELGTACLKARVALLASLQDGAFQNALMISQLL 293

Query: 273 PSLKGKTYLDVPQVTC-SPDHEVQPTLPSNPGPGPTSASNITVIYTINNQLRGVELLFNE 331
           P L  KTY+D+    C +P   ++P   + P               I+  L+ + LL   
Sbjct: 294 PVLNHKTYIDLIFPDCLAPRVMLEPAAETIP----------QTQEIISVTLQVLSLLPPY 343

Query: 332 TINVSVKSGSVLLVVLEEAQRKNPMFKFETTMTSWGLVVSSINNIAENVNHKTYWQFLSG 391
             ++SV +GS +  VL++A      F +ET  +  G  ++S+  + +    + +WQ L  
Sbjct: 344 RQSISVLAGSTVEDVLKKAHELGG-FTYETQASLSGPYLTSV--MGKAAGEREFWQLLRD 400

Query: 392 V-TPLNEGVADYIPFNHEHI 410
             TPL +G+ADY P + E I
Sbjct: 401 PNTPLLQGIADYRPKDGETI 420


>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate
           3A [Homo sapiens]
          Length = 1115

 Score = 32.3 bits (72), Expect = 0.82
 Identities = 28/98 (28%), Positives = 51/98 (52%), Gaps = 9/98 (9%)

Query: 31  AQEPLVNGIQVLMENSVTSSAYPNPSILIAMNLAGAYNLKAQK---LLTYQLMSSDNNDL 87
           +Q PL   +Q+ +ENS++S A    SIL   N      L  Q+   +  + L++ +N+  
Sbjct: 232 SQNPL--HLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKF 289

Query: 88  TIGQLGLTIMALTSSCRDPGDKVSILQRQMENWAPSSP 125
            +G    +I+ +T++     D +S LQ Q+E+   S+P
Sbjct: 290 HLG----SIINITANLPSTQDLLSFLQIQLESIKNSTP 323


>gi|55741864 zinc finger, FYVE domain containing 28 [Homo sapiens]
          Length = 887

 Score = 32.0 bits (71), Expect = 1.1
 Identities = 37/157 (23%), Positives = 60/157 (38%), Gaps = 27/157 (17%)

Query: 84  NNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENWAPSSPNAEASAFY-----GPSLA 138
           NN+L         +A TSSC     ++      ++ W   + +AE +        G  L+
Sbjct: 460 NNNLEAEGTDGASLAGTSSCSCLDSRL-----HLDGWEVGADDAETAEMIAHRTGGMKLS 514

Query: 139 ILALCQKNSEATLPIAVRFAKTLLA------NSSPFNVDTGAMATLALTCMYNKIPVGSE 192
              +    S  +L  AV   +          +  P  + TGA   L  +C    +  GS 
Sbjct: 515 ATVIFNPKSPTSLDSAVATQEAASEPVAEGMDGGPHKLSTGATNCLLHSC----VCCGS- 569

Query: 193 EGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLA 229
                  G   +D+VE++  K    G+IG  Y+ GLA
Sbjct: 570 ------CGDSREDVVERLREKCSPGGVIGASYAAGLA 600


>gi|71725360 zinc finger protein 609 [Homo sapiens]
          Length = 1411

 Score = 31.2 bits (69), Expect = 1.8
 Identities = 15/47 (31%), Positives = 24/47 (51%), Gaps = 5/47 (10%)

Query: 227 GLAMQALSVTPEPSKKEWNCKKTTDMILNEIKQGKFHNPMSIAQILP 273
           G A+  L   PEP + E  C+     +L ++K  K  +P+S   +LP
Sbjct: 220 GAALNPLGTKPEPEEGENECR-----LLKKVKSEKMESPVSTPAVLP 261


>gi|38201621 eukaryotic translation initiation factor 4 gamma, 1
           isoform 1 [Homo sapiens]
          Length = 1599

 Score = 30.0 bits (66), Expect = 4.1
 Identities = 17/83 (20%), Positives = 37/83 (44%), Gaps = 8/83 (9%)

Query: 290 PDHEVQPTLPSNPGPGPT--------SASNITVIYTINNQLRGVELLFNETINVSVKSGS 341
           P+H    + PS+P P P+        S  N+ V+    + +  +++   E+  +S ++G 
Sbjct: 250 PEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGE 309

Query: 342 VLLVVLEEAQRKNPMFKFETTMT 364
              +  E      P+ + E T++
Sbjct: 310 PYRLSPEPTPLAEPILEVEVTLS 332


>gi|38201627 eukaryotic translation initiation factor 4 gamma, 1
           isoform 2 [Homo sapiens]
          Length = 1512

 Score = 30.0 bits (66), Expect = 4.1
 Identities = 17/83 (20%), Positives = 37/83 (44%), Gaps = 8/83 (9%)

Query: 290 PDHEVQPTLPSNPGPGPT--------SASNITVIYTINNQLRGVELLFNETINVSVKSGS 341
           P+H    + PS+P P P+        S  N+ V+    + +  +++   E+  +S ++G 
Sbjct: 163 PEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGE 222

Query: 342 VLLVVLEEAQRKNPMFKFETTMT 364
              +  E      P+ + E T++
Sbjct: 223 PYRLSPEPTPLAEPILEVEVTLS 245


>gi|38201625 eukaryotic translation initiation factor 4 gamma, 1
           isoform 3 [Homo sapiens]
          Length = 1435

 Score = 30.0 bits (66), Expect = 4.1
 Identities = 17/83 (20%), Positives = 37/83 (44%), Gaps = 8/83 (9%)

Query: 290 PDHEVQPTLPSNPGPGPT--------SASNITVIYTINNQLRGVELLFNETINVSVKSGS 341
           P+H    + PS+P P P+        S  N+ V+    + +  +++   E+  +S ++G 
Sbjct: 86  PEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGE 145

Query: 342 VLLVVLEEAQRKNPMFKFETTMT 364
              +  E      P+ + E T++
Sbjct: 146 PYRLSPEPTPLAEPILEVEVTLS 168


>gi|38201623 eukaryotic translation initiation factor 4 gamma, 1
           isoform 1 [Homo sapiens]
          Length = 1599

 Score = 30.0 bits (66), Expect = 4.1
 Identities = 17/83 (20%), Positives = 37/83 (44%), Gaps = 8/83 (9%)

Query: 290 PDHEVQPTLPSNPGPGPT--------SASNITVIYTINNQLRGVELLFNETINVSVKSGS 341
           P+H    + PS+P P P+        S  N+ V+    + +  +++   E+  +S ++G 
Sbjct: 250 PEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGE 309

Query: 342 VLLVVLEEAQRKNPMFKFETTMT 364
              +  E      P+ + E T++
Sbjct: 310 PYRLSPEPTPLAEPILEVEVTLS 332


>gi|38201619 eukaryotic translation initiation factor 4 gamma, 1
           isoform 4 [Homo sapiens]
          Length = 1403

 Score = 30.0 bits (66), Expect = 4.1
 Identities = 17/83 (20%), Positives = 37/83 (44%), Gaps = 8/83 (9%)

Query: 290 PDHEVQPTLPSNPGPGPT--------SASNITVIYTINNQLRGVELLFNETINVSVKSGS 341
           P+H    + PS+P P P+        S  N+ V+    + +  +++   E+  +S ++G 
Sbjct: 54  PEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGE 113

Query: 342 VLLVVLEEAQRKNPMFKFETTMT 364
              +  E      P+ + E T++
Sbjct: 114 PYRLSPEPTPLAEPILEVEVTLS 136


>gi|239754626 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 103

 Score = 29.6 bits (65), Expect = 5.3
 Identities = 19/89 (21%), Positives = 39/89 (43%), Gaps = 3/89 (3%)

Query: 224 YSTGLAMQALSVTPEPSKKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKG---KTY 280
           ++ G +  AL +T + SK + +           + + K    + +A++ P   G   +  
Sbjct: 11  WAPGPSNAALDLTLKGSKDKASGAGARGAGREVVAEAKGRRDLGLARVCPRRPGAGRRCT 70

Query: 281 LDVPQVTCSPDHEVQPTLPSNPGPGPTSA 309
           +   +    P+ + +  LP  PGPGP+ A
Sbjct: 71  VSPREADLGPEKDTRLDLPRRPGPGPSGA 99


>gi|66730481 neuregulin 3 [Homo sapiens]
          Length = 696

 Score = 29.3 bits (64), Expect = 6.9
 Identities = 15/52 (28%), Positives = 22/52 (42%)

Query: 101 SSCRDPGDKVSILQRQMENWAPSSPNAEASAFYGPSLAILALCQKNSEATLP 152
           SSC  PG +  +L R      P SP +      GP+   L   +   + T+P
Sbjct: 474 SSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIP 525


>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
          Length = 822

 Score = 29.3 bits (64), Expect = 6.9
 Identities = 24/100 (24%), Positives = 44/100 (44%), Gaps = 18/100 (18%)

Query: 250 TDMILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQVTCSPDHEVQPTLPSNPGPGPTSA 309
           T ++  EI        MS+ QI PS +   ++DV + T + + E++              
Sbjct: 233 TSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFD------------ 280

Query: 310 SNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEE 349
              T +   N  L+  E+++N   N++ +S  V+L  L E
Sbjct: 281 ---TSLLEENENLQANEIMWN---NLTAESLQVMLKTLAE 314


>gi|19913406 DNA topoisomerase II, alpha isozyme [Homo sapiens]
          Length = 1531

 Score = 28.9 bits (63), Expect = 9.0
 Identities = 24/86 (27%), Positives = 36/86 (41%), Gaps = 4/86 (4%)

Query: 208  EKISMKIKDNGIIGDIYSTGLAMQALSVTPEPSKKE---WNCKKTTDMILNEIKQGKFHN 264
            +K   KIK+    G     G+ ++ L    E  +K       KK T +    IK+GK  N
Sbjct: 1233 KKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRN 1292

Query: 265  PMSIAQILPSLKGKTYLDVPQVTCSP 290
            P S ++   S   ++  DVP     P
Sbjct: 1293 PWSDSESDRS-SDESNFDVPPRETEP 1317


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.129    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,494,966
Number of Sequences: 37866
Number of extensions: 661139
Number of successful extensions: 2301
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2288
Number of HSP's gapped (non-prelim): 20
length of query: 417
length of database: 18,247,518
effective HSP length: 105
effective length of query: 312
effective length of database: 14,271,588
effective search space: 4452735456
effective search space used: 4452735456
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.