Search of human proteins with 31652238

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31652238 cut-like homeobox 1 isoform c [Homo sapiens]
         (676 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31652238 cut-like homeobox 1 isoform c [Homo sapiens]             1292   0.0  
gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens]             1287   0.0  
gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens]             738   0.0  
gi|116517292 cut-like 2 [Homo sapiens]                                348   7e-96
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    91   5e-18
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    89   1e-17
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        87   7e-17
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        87   7e-17
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         87   7e-17
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         87   7e-17
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         87   7e-17
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         87   7e-17
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         87   7e-17
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         87   7e-17
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         86   1e-16
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    86   1e-16
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    86   1e-16
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    86   1e-16
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    86   1e-16
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    85   2e-16
gi|4506751 restin isoform a [Homo sapiens]                             84   3e-16
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]    84   6e-16
gi|205277396 dynactin 1 isoform 4 [Homo sapiens]                       83   9e-16
gi|205277392 dynactin 1 isoform 3 [Homo sapiens]                       83   9e-16
gi|13259508 dynactin 1 isoform 2 [Homo sapiens]                        83   9e-16
gi|13259510 dynactin 1 isoform 1 [Homo sapiens]                        83   9e-16
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             82   2e-15
gi|31982906 cingulin-like 1 [Homo sapiens]                             82   2e-15
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    81   4e-15
gi|38044112 restin isoform b [Homo sapiens]                            80   5e-15

>gi|31652238 cut-like homeobox 1 isoform c [Homo sapiens]
          Length = 676

 Score = 1292 bits (3344), Expect = 0.0
 Identities = 676/676 (100%), Positives = 676/676 (100%)

Query: 1   MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL 60
           MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL
Sbjct: 1   MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL 60

Query: 61  RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH 120
           RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH
Sbjct: 61  RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH 120

Query: 121 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180
           DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ
Sbjct: 121 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180

Query: 181 NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240
           NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI
Sbjct: 181 NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240

Query: 241 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVE 300
           EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVE
Sbjct: 241 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVE 300

Query: 301 LAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADY 360
           LAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADY
Sbjct: 301 LAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADY 360

Query: 361 EEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCA 420
           EEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCA
Sbjct: 361 EEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCA 420

Query: 421 ELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALF 480
           ELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALF
Sbjct: 421 ELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALF 480

Query: 481 YGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRA 540
           YGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRA
Sbjct: 481 YGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRA 540

Query: 541 DNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDK 600
           DNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDK
Sbjct: 541 DNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDK 600

Query: 601 ATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLH 660
           ATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLH
Sbjct: 601 ATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLH 660

Query: 661 KFHENDNGAAAGDLWQ 676
           KFHENDNGAAAGDLWQ
Sbjct: 661 KFHENDNGAAAGDLWQ 676


>gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens]
          Length = 678

 Score = 1287 bits (3331), Expect = 0.0
 Identities = 676/678 (99%), Positives = 676/678 (99%), Gaps = 2/678 (0%)

Query: 1   MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL 60
           MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL
Sbjct: 1   MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL 60

Query: 61  RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH 120
           RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH
Sbjct: 61  RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH 120

Query: 121 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180
           DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ
Sbjct: 121 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180

Query: 181 NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240
           NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI
Sbjct: 181 NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240

Query: 241 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV--AIEVLTRSSLE 298
           EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV  AIEVLTRSSLE
Sbjct: 241 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE 300

Query: 299 VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQA 358
           VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQA
Sbjct: 301 VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQA 360

Query: 359 DYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGR 418
           DYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGR
Sbjct: 361 DYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGR 420

Query: 419 CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATA 478
           CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATA
Sbjct: 421 CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATA 480

Query: 479 LFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSL 538
           LFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSL
Sbjct: 481 LFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSL 540

Query: 539 RADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPW 598
           RADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPW
Sbjct: 541 RADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPW 600

Query: 599 DKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADH 658
           DKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADH
Sbjct: 601 DKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADH 660

Query: 659 LHKFHENDNGAAAGDLWQ 676
           LHKFHENDNGAAAGDLWQ
Sbjct: 661 LHKFHENDNGAAAGDLWQ 678


>gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens]
          Length = 1505

 Score =  738 bits (1904), Expect = 0.0
 Identities = 397/401 (99%), Positives = 399/401 (99%), Gaps = 2/401 (0%)

Query: 19  QLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 78
           +L+RELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL
Sbjct: 8   RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67

Query: 79  SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 138
           SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK
Sbjct: 68  SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 127

Query: 139 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 198
           EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT
Sbjct: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187

Query: 199 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 258
           SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ
Sbjct: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247

Query: 259 REAETLREQLSSANHSLQLASQIQKAPDV--AIEVLTRSSLEVELAAKEREIAQLVEDVQ 316
           REAETLREQLSSANHSLQLASQIQKAPDV  AIEVLTRSSLEVELAAKEREIAQLVEDVQ
Sbjct: 248 REAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ 307

Query: 317 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA 376
           RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA
Sbjct: 308 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA 367

Query: 377 PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
           PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG
Sbjct: 368 PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 408



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 30/137 (21%), Positives = 67/137 (48%), Gaps = 18/137 (13%)

Query: 290 EVLTRSSLEVELAAKERE----IAQLVEDVQRLQASLT---KLRENSASQISQLEQQL-S 341
           E+L R     +L  + +E    + Q + D Q + A  +   + REN    +++L Q++  
Sbjct: 588 EILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPK 647

Query: 342 AKNSTLKQLEEKLKG---------QADYEEVKKELNILKSMEFA-PSEGAGTQDAAKPLE 391
            +N +   +  +++          ++  E+ K+EL + K+ E A PS  +G+ ++   + 
Sbjct: 648 RRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIR 707

Query: 392 VLLLEKNRSLQSENAAL 408
            +L +  R ++++ AAL
Sbjct: 708 SILQQARREMEAQQAAL 724


>gi|116517292 cut-like 2 [Homo sapiens]
          Length = 1486

 Score =  348 bits (894), Expect = 7e-96
 Identities = 198/401 (49%), Positives = 276/401 (68%), Gaps = 6/401 (1%)

Query: 1   MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL 60
           MAANVGSMFQYWKRFDL++LQ+EL++ A+ L+ RQ+ESE S K LIE  REFKKN PE++
Sbjct: 1   MAANVGSMFQYWKRFDLRRLQKELNSVASELSARQEESEHSHKHLIELRREFKKNVPEEI 60

Query: 61  RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ-RL 119
           R+ VAP+LKSFQ E+ ALSKRS+EAEAAFL+VYK+LI+ PDPVP  +  + L  ++Q   
Sbjct: 61  REMVAPVLKSFQAEVVALSKRSQEAEAAFLSVYKQLIEAPDPVPVFEAARSLDDRLQPPS 120

Query: 120 HDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKL 179
            D   + ++   T  + N E    K Q          + E  +      +  AL  E  L
Sbjct: 121 FDPSGQPRRDLHTSWKRNPELLSPKEQREGTSPAGPTLTEGSRLPGIPGK--ALLTETLL 178

Query: 180 QNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADE 239
           Q + AEK++ LQE Q++  ++L EAE K++ L +AL+ T+ EL +L+ KYDEE  +KADE
Sbjct: 179 QRNEAEKQKGLQEVQITLAARLGEAEEKIKVLHSALKATQAELLELRRKYDEEAASKADE 238

Query: 240 IEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPD---VAIEVLTRSS 296
           + +IMT+LE+ANQRAE AQRE E+LREQL+S N S++LA    + P    V   + +   
Sbjct: 239 VGLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRLACCSPQGPSGDKVNFTLCSGPR 298

Query: 297 LEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG 356
           LE  LA+K+REI +L++DVQ LQ+SL +L E SA+QI+ LE+QL+AK+  +++LEEKL+ 
Sbjct: 299 LEAALASKDREILRLLKDVQHLQSSLQELEEASANQIADLERQLTAKSEAIEKLEEKLQA 358

Query: 357 QADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 397
           Q+DYEE+K EL+ILK+M+ A S  +  Q  AKP + LL+ K
Sbjct: 359 QSDYEEIKTELSILKAMKLASSTCSLPQGMAKPEDSLLIAK 399


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 125/569 (21%), Positives = 243/569 (42%), Gaps = 63/569 (11%)

Query: 13   KRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFK---------KNTPEDLRK- 62
            K F+L QLQ ++D         Q + ++ + R+ E   E +         +    DL + 
Sbjct: 1087 KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE 1146

Query: 63   --QVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLID--VPDPVPALDLGQQLQLKVQR 118
              +++  L+   G   A  + +K+ EA F  + + L +  +     A  L ++    V  
Sbjct: 1147 LEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAE 1206

Query: 119  LHDIETENQKLRETLEEYNKEF-AEVKNQEVTIKAL---KEKIREYEQTLKNQAETIALE 174
            L +     Q++++ LE+   E   E+ +    I+AL   K  I    +T+++Q   I  +
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAK 1266

Query: 175  KEQKLQ--NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEE 232
             EQ+ Q  +D   ++ +LQ      + ++EE E  +  L  + +    +L +LK + +EE
Sbjct: 1267 DEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEE 1326

Query: 233  TTAK---ADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAI 289
            T AK   A  ++    D +   ++ E  Q     L+  LS AN   ++A    K    AI
Sbjct: 1327 TKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANS--EVAQWRTKYETDAI 1384

Query: 290  EVLTR-SSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLK 348
            +        + +LA + +E  +  E      ASL K ++    ++  L + L   ++   
Sbjct: 1385 QRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACA 1444

Query: 349  QLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQ---SEN 405
             L++K   Q ++++V  E    + ++ + +E    Q  ++ L   L +   + +    + 
Sbjct: 1445 TLDKK---QRNFDKVLAEWK--QKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQL 1499

Query: 406  AALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHR 465
              LR  N +L    ++L  +I E      E  +    +EQ+ S +Q +   + EG+ EH 
Sbjct: 1500 ETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQ-VALEEVEGSLEHE 1558

Query: 466  LEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRER-FRARNQELEAENRLA 524
              KI                         +V   LS + S+ +R    +++E+E   R +
Sbjct: 1559 ESKIL------------------------RVQLELSQVKSELDRKVIEKDEEIEQLKRNS 1594

Query: 525  QHTLQALQSELDS---LRADNIKLFEKIK 550
            Q   +ALQS LD+    R D ++L +K++
Sbjct: 1595 QRAAEALQSVLDAEIRSRNDALRLKKKME 1623



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 101/521 (19%), Positives = 209/521 (40%), Gaps = 96/521 (18%)

Query: 24   LDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSK 83
            L+A    L  R +E E+    L+ + R        +L  + + L +        L+K  K
Sbjct: 919  LEAKVKELTERLEEEEEMNSELVAKKR--------NLEDKCSSLKRDIDDLELTLTKVEK 970

Query: 84   EAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEV 143
            E  A    V              +L +++    + +  +  E + L+E  ++   +    
Sbjct: 971  EKHATENKVK-------------NLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVE 1017

Query: 144  KNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEE 203
            +++   +  +  K+ +    L+      +LE+E+KL+ D    +RKL+     +   + +
Sbjct: 1018 EDKVNGLIKINAKLEQQTDDLEG-----SLEQEKKLRADLERAKRKLEGDLKMSQESIMD 1072

Query: 204  AEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAET 263
             E+  Q ++  L+K   EL  L+ K D+E      + +  + +L+   +  E       T
Sbjct: 1073 LENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSL-QFQKKIKELQARIEELEEEIEAEHT 1131

Query: 264  LREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAK-EREIAQLVEDVQRL---- 318
            LR ++        LA ++++  +   E    +S ++E+  K E E  ++  D++      
Sbjct: 1132 LRAKIEKQRS--DLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1189

Query: 319  QASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPS 378
            +A+   LR+  A  +++L +Q+      L+++++KL  + +  E+K E++          
Sbjct: 1190 EATAATLRKKQADSVAELGEQI----DNLQRVKQKL--EKEKSELKMEID---------- 1233

Query: 379  EGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRE 438
                  D A  +E               AL  S S++   C  ++ + +E  A   +Q +
Sbjct: 1234 ------DMASNIE---------------ALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQ 1272

Query: 439  LIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDS 498
            LI  L    + +Q+       G   HR+E+    I + T                    S
Sbjct: 1273 LIHDLNMQKARLQT-----QNGELSHRVEEKESLISQLT-------------------KS 1308

Query: 499  LLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLR 539
              ++     E  R   +E +A+N +A H LQ+ + + D LR
Sbjct: 1309 KQALTQQLEELKRQMEEETKAKNAMA-HALQSSRHDCDLLR 1348



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 90/449 (20%), Positives = 184/449 (40%), Gaps = 69/449 (15%)

Query: 121  DIETENQKLRETLEEYNKEFA--EVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQK 178
            + E E   ++E  E   +E A  E + +E+  K +     + +  L+ Q+ET  L   ++
Sbjct: 848  EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEE 907

Query: 179  LQNDFAEKERKLQETQMSTTSKLEEAEH-------KVQSLQTALEKTRTELFDLK---TK 228
                  + +  L+      T +LEE E        K ++L+      + ++ DL+   TK
Sbjct: 908  RCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTK 967

Query: 229  YDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVA 288
             ++E  A  ++++ +  ++    +      +E ++L+E        LQ+           
Sbjct: 968  VEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEED-------- 1019

Query: 289  IEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLK 348
             +V     +  +L  +  ++   +E  ++L+A L + +      +   ++ +    +  +
Sbjct: 1020 -KVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQ 1078

Query: 349  QLEEKLKGQADYE----EVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSE 404
            Q+EEKLK + ++E    + K +   + S++F        Q   K L+  + E    +++E
Sbjct: 1079 QIEEKLK-KKEFELSQLQAKIDDEQVHSLQF--------QKKIKELQARIEELEEEIEAE 1129

Query: 405  N---AALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGA 461
            +   A +    SDL+    E+  R+ EA    + Q E+  + E +    Q ++R   E  
Sbjct: 1130 HTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAE---FQKMRRDLEEAT 1186

Query: 462  AEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAEN 521
             +H          EATA            L + Q DS+   +  Q +  +   Q+LE E 
Sbjct: 1187 LQH----------EATA----------ATLRKKQADSVAE-LGEQIDNLQRVKQKLEKEK 1225

Query: 522  RLAQHTLQALQSELDSLRADNIKLFEKIK 550
                     L+ E+D + A NI+   K K
Sbjct: 1226 -------SELKMEIDDM-ASNIEALSKSK 1246



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 81/366 (22%), Positives = 158/366 (43%), Gaps = 43/366 (11%)

Query: 74   EIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH-DIETENQKLRET 132
            EI+ L + S+ A  A  +V     ++     AL L ++++  +  +   +   N+++ ET
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDA--EIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAET 1643

Query: 133  LEEYNKEFAEVKNQEVTIK-ALKEKIREYEQ-TLKNQAETIALEK--EQKLQNDFAEKER 188
             +       ++K+ ++ +  AL+      EQ  +  +   + LE+  E K+  +  E+ R
Sbjct: 1644 QKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTR 1703

Query: 189  KLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLE 248
            +L E +      L +A  +VQ L +      T L + K K + +      E+E  + +  
Sbjct: 1704 RLSEQE------LLDASDRVQLLHSQ----NTSLINTKKKLEADIAQCQAEVENSIQESR 1753

Query: 249  RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVE-LAAKERE 307
             A ++A+ A  +A  + E+L     +     +++K  +  ++ L     E E LA K  +
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK 1813

Query: 308  IAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 367
                 + +Q+L+           +++ +LE +L  +    K+  E LKG   YE   KE+
Sbjct: 1814 -----KQIQKLE-----------NRVRELENELDVEQ---KRGAEALKGAHKYERKVKEM 1854

Query: 368  NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRIT 427
                  E         QD    L+  +  K+   Q+E A  + +N+ LS RC  +Q  + 
Sbjct: 1855 TY--QAEEDHKNILRLQDLVDKLQAKV--KSYKRQAEEAEEQ-ANTQLS-RCRRVQHELE 1908

Query: 428  EAVATA 433
            EA   A
Sbjct: 1909 EAAERA 1914



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 52/256 (20%), Positives = 106/256 (41%), Gaps = 24/256 (9%)

Query: 16   DLQQLQRELDATATV--LANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
            +L++++  L+ T     L+ ++      R +L+        NT + L   +A      Q 
Sbjct: 1688 ELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQC----QA 1743

Query: 74   EIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH-DIETENQKLRET 132
            E++   + S+ AE       K + D       L   Q     ++R+  ++E   + L+  
Sbjct: 1744 EVENSIQESRNAEE---KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1800

Query: 133  LEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQE 192
            L+E   E   +K  +  I+ L+ ++RE E  L         + EQK   +  +   K + 
Sbjct: 1801 LDE--AEQLALKGGKKQIQKLENRVRELENEL---------DVEQKRGAEALKGAHKYER 1849

Query: 193  TQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDE---ETTAKADEIEMIMTDLER 249
                 T + EE    +  LQ  ++K + ++   K + +E   +   +      +  +LE 
Sbjct: 1850 KVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEE 1909

Query: 250  ANQRAEVAQREAETLR 265
            A +RA++A+ +   LR
Sbjct: 1910 AAERADIAESQVNKLR 1925



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 61/284 (21%), Positives = 119/284 (41%), Gaps = 26/284 (9%)

Query: 302  AAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYE 361
            A  E+E+A + ED +R +  L +          ++   L  KN    Q++ + +   D E
Sbjct: 847  AEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAE 906

Query: 362  EVKKELNILKS---MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGR 418
            E  +   ++KS   +E    E     +  + +   L+ K R+L+ + ++L+    DL   
Sbjct: 907  E--RCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDL--- 961

Query: 419  CAELQVRITEAVATATEQR-----ELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPI 473
              EL +   E    ATE +     E +  LE+++S +   ++   + A +  L+ +    
Sbjct: 962  --ELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTK-EKKSLQEAHQQTLDDLQVEE 1018

Query: 474  KEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQS 533
             +   L          A  E Q D L   +  Q ++ RA   +LE   R  +  L+  Q 
Sbjct: 1019 DKVNGLI------KINAKLEQQTDDLEGSL-EQEKKLRA---DLERAKRKLEGDLKMSQE 1068

Query: 534  ELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERL 577
             +  L  D  ++ EK+K  +    +     D E  +S Q+++++
Sbjct: 1069 SIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKI 1112


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 129/617 (20%), Positives = 261/617 (42%), Gaps = 100/617 (16%)

Query: 13   KRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ 72
            ++ +L    R+L+     L  +Q+E E++RK L +Q    +     D +K+V   L + +
Sbjct: 1330 QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL-ADTKKKVDDDLGTIE 1388

Query: 73   GEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRET 132
               +A  K  K+AEA                    L Q+L+ K      +E    +L++ 
Sbjct: 1389 SLEEAKKKLLKDAEA--------------------LSQRLEEKALAYDKLEKTKNRLQQE 1428

Query: 133  LEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQE 192
            L++      ++ +Q      L++K ++++Q L  +    A   E++   D AE E + +E
Sbjct: 1429 LDDLT---VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER---DRAEAEAREKE 1482

Query: 193  TQ-MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 251
            T+ +S    LEEA    +  +   ++ R ++ DL         +  D++   + +LE++ 
Sbjct: 1483 TKALSLARALEEALEAKEEFERQNKQLRADMEDL--------MSSKDDVGKNVHELEKSK 1534

Query: 252  QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQ- 310
            +  E   ++ E +R QL      LQ     +   +V ++ + ++  E +L  ++ +  + 
Sbjct: 1535 RALE---QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM-KAQFERDLQTRDEQNEEK 1590

Query: 311  ---LVEDVQRLQASLTKLRENSASQI--------------SQLEQQLSAKNSTLKQLEEK 353
               L++ V+ L+A L   R+  A  +              +Q+E    A++  +KQL + 
Sbjct: 1591 KRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKL 1650

Query: 354  LKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNS 413
                 DY+   +E    +   FA S+   ++   K LE  +L+    L S   A R +  
Sbjct: 1651 QAQMKDYQRELEEARASRDEIFAQSK--ESEKKLKSLEAEILQLQEELASSERARRHAEQ 1708

Query: 414  DLSGRCAELQVRITEAVATATEQREL---IARLEQDLSIIQSIQRPDAEGAAEHRLEKIP 470
            +      E+    +   A   E+R L   IA+LE++L         + +   E   ++  
Sbjct: 1709 ERDELADEITNSASGKSALLDEKRRLEARIAQLEEELE--------EEQSNMELLNDRFR 1760

Query: 471  EPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELE-AENRLAQHTLQ 529
            +   +   L    AA  S A    + D+    +  Q +  +A+ QELE A     + T+ 
Sbjct: 1761 KTTLQVDTLNAELAAERSAA---QKSDNARQQLERQNKELKAKLQELEGAVKSKFKATIS 1817

Query: 530  ALQSELDSL----------RADNIKLFEKIK------FLQSYPGRGSGSDDTELRYSSQY 573
            AL++++  L          RA   KL  + +      F+Q          + E R++ QY
Sbjct: 1818 ALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV---------EDERRHADQY 1868

Query: 574  EERLDPFSSFSKRERQR 590
            +E+++  ++  K+ +++
Sbjct: 1869 KEQMEKANARMKQLKRQ 1885



 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 119/523 (22%), Positives = 227/523 (43%), Gaps = 86/523 (16%)

Query: 131  ETLEEYNKEFAEVKNQEVTIKA-LKEKIREYEQTLKN--------QAETIALEKEQKLQN 181
            E L+  ++E  +VK ++  ++  L+E  R+++Q L+         QAET    + ++++ 
Sbjct: 852  EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRA 911

Query: 182  DFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIE 241
              A K+++L+E      S++EE E + Q LQ   +K +  + DL+ + DEE  A+     
Sbjct: 912  RLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ---- 967

Query: 242  MIMTDLERANQRAEVAQREAE--TLREQLSS------------ANHSLQLASQIQKAPDV 287
                 LE+    A++ + E E   L +Q S             A  S QLA + +KA ++
Sbjct: 968  --KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025

Query: 288  A----IEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAK 343
            A     + +  S LE  L  +E+   +L +  ++L    T L++    QI++L+ Q+   
Sbjct: 1026 AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQD----QIAELQAQIDEL 1081

Query: 344  NSTLKQLEEKLKG---QADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRS 400
               L + EE+L+G   + D E + K  N LK                + L+  + E    
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKN-NALK--------------VVRELQAQIAELQED 1126

Query: 401  LQSENAALRISNS---DLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQ------ 451
             +SE A+   +     DLS     L+  + + + T   Q+EL  + EQ+++ ++      
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE 1186

Query: 452  ----SIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQ--------VDSL 499
                  Q  D        LE++ E +++A            G   + +        +  +
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQV 1246

Query: 500  LSIISSQRERFRARNQELEAE----NRLAQHTLQ---ALQSELDSLRADNIKLFEK--IK 550
             +    +R++  A+ QEL A+    +RL     +    LQ+ELD++ +  ++  EK  IK
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV-STLLEEAEKKGIK 1305

Query: 551  FLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL 593
            F +      S   DT+     +  ++L+  S   + E ++  L
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSL 1348



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 141/595 (23%), Positives = 251/595 (42%), Gaps = 76/595 (12%)

Query: 17   LQQLQRELDATATVLANRQDESEQSRKRLIEQSREF--KKNTPEDLRKQVAPLLKSFQGE 74
            L+   +EL     VL   + ESE  RK+L  Q +E   K +  + LR ++A      Q E
Sbjct: 1229 LETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNE 1288

Query: 75   IDALSKRSKEAEAAFLNVYK-------RLIDVPDPVPALDLGQQLQLKVQRLHDIETENQ 127
            +D +S   +EAE   +   K       +L D  + +   +  Q+L L   R+  +E E  
Sbjct: 1289 LDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQE-ETRQKLNLS-SRIRQLEEEKN 1346

Query: 128  KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIAL--EKEQKLQNDFAE 185
             L+E  EE   E    KN E  + AL+ ++ + ++ + +   TI    E ++KL  D   
Sbjct: 1347 SLQEQQEE---EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA 1403

Query: 186  KERKLQETQMSTTSKLEEAEHKVQ----SLQTALEKTRTELFDLKTKYDEETTAKADEIE 241
              ++L+E  ++   KLE+ ++++Q     L   L+  R    +L+ K  +     A+E +
Sbjct: 1404 LSQRLEEKALA-YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEE-K 1461

Query: 242  MIMTDLERANQRAEVAQREAETLREQLSSA-NHSLQLASQIQKAPDVAIEVLTRSSLEVE 300
             I         RAE   RE ET    L+ A   +L+   + ++          R+ +E +
Sbjct: 1462 SISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQ-----NKQLRADME-D 1515

Query: 301  LAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSA-KNSTLK----------Q 349
            L + + ++ + V ++++ + +L +  E   +Q+ +LE +L A +++ L+          Q
Sbjct: 1516 LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQ 1575

Query: 350  LEEKLKGQADYEEVKKELNILKSMEF-APSEGAGTQDA-----AKPLEVLLLEKNRSLQS 403
             E  L+ + +  E KK L I +  E  A  E    Q A      K +E+ L +    +++
Sbjct: 1576 FERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEA 1635

Query: 404  ENAA----------LRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSI 453
             N A          L+    D      E +    E  A + E  + +  LE ++  +Q  
Sbjct: 1636 ANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE- 1694

Query: 454  QRPDAEGAAEHRLEKIPEPIKEATALFYGPAA--------PASGALPEGQVDSLLSIISS 505
            +   +E A  H  ++  E   E T    G +A         A  A  E +++   S +  
Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMEL 1754

Query: 506  QRERFR-------ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 553
              +RFR         N EL AE   AQ +  A Q     L   N +L  K++ L+
Sbjct: 1755 LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQ----QLERQNKELKAKLQELE 1805



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 120/561 (21%), Positives = 236/561 (42%), Gaps = 37/561 (6%)

Query: 17   LQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPE-----DLRKQVAPLLKSF 71
            L++ +++L   A  L+ R +E   +  +L +     ++   +     D ++QVA  L+  
Sbjct: 1390 LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449

Query: 72   QGEIDALSKRSKEAEAAFLNVYKRLIDVP--DPVPALDLGQQLQLKVQRLHDIETENQKL 129
            Q + D L    K   A +     R           AL L + L+  ++   + E +N++L
Sbjct: 1450 QKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQL 1509

Query: 130  RETLEEYNKEFAEVKNQ----EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAE 185
            R  +E+      +V       E + +AL++++ E    L+   + +   ++ KL+ +   
Sbjct: 1510 RADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1569

Query: 186  KERKLQ-ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            +  K Q E  + T    E+ E K + L   + +   EL D + K      A   ++E+ +
Sbjct: 1570 QAMKAQFERDLQTRD--EQNEEKKRLLIKQVRELEAELED-ERKQRALAVASKKKMEIDL 1626

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAK 304
             DLE   + A  A+ E      +L +     Q   +  +A    I   ++ S E +L + 
Sbjct: 1627 KDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES-EKKLKSL 1685

Query: 305  EREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEV 363
            E EI QL E++    AS  + R ++  +  +L  +++   S    L +EK + +A   ++
Sbjct: 1686 EAEILQLQEEL----ASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741

Query: 364  KKELNILKS-MEFAPSEGAGTQDAAKPLEV-LLLEKNRSLQSENAALRIS--NSDLSGRC 419
            ++EL   +S ME        T      L   L  E++ + +S+NA  ++   N +L  + 
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKL 1801

Query: 420  AELQVRI-TEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATA 478
             EL+  + ++  AT +     I +LE+ L      Q      AA   + +  + +KE   
Sbjct: 1802 QELEGAVKSKFKATISALEAKIGQLEEQLE-----QEAKERAAANKLVRRTEKKLKEIFM 1856

Query: 479  LFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSL 538
                    A       Q    +   +++ ++ + + +E E E   A  + + LQ ELD  
Sbjct: 1857 QVEDERRHAD------QYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDA 1910

Query: 539  RADNIKLFEKIKFLQSYPGRG 559
               N  L  ++  L++   RG
Sbjct: 1911 TEANEGLSREVSTLKNRLRRG 1931



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 119/571 (20%), Positives = 213/571 (37%), Gaps = 50/571 (8%)

Query: 22   RELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKR 81
            REL A    L    +  + SR +  +Q R+  +   E L+ ++   L +   + +  +KR
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEEL-EALKTELEDTLDTTAAQQELRTKR 1172

Query: 82   SKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFA 141
              E E A L                D+ Q+    ++ L +   + ++ +  LE+ NK+  
Sbjct: 1173 --EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK-NKQGL 1229

Query: 142  EVKNQEVT--IKALKEKIREYEQTLKN-----QAETIALEKEQKLQNDFAEKERKLQETQ 194
            E  N+E+   +K L++   E E   K      Q     + +  +L+ + AEK  KLQ   
Sbjct: 1230 ETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL 1289

Query: 195  MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA 254
             + ++ LEEAE K            ++L D +    EET  K + +   +  LE      
Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLN-LSSRIRQLEEEKNSL 1348

Query: 255  EVAQREAETLREQLSSANHSL--QLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLV 312
            +  Q E E  R+ L     +L  QLA   +K  D    + +    + +L      ++Q +
Sbjct: 1349 QEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL 1408

Query: 313  EDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKS 372
            E+       L K +     ++  L   L  +      LE+K K        +K ++   +
Sbjct: 1409 EEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYA 1468

Query: 373  MEFAPSEGAGTQDAAKPLEVL-----LLEKNRSLQSENAALRISNSDL------------ 415
             E   +E    +   K L +       LE     + +N  LR    DL            
Sbjct: 1469 EERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVH 1528

Query: 416  ----SGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPE 471
                S R  E QV   E + T  E+ E   +  +D  +   +     +   E  L+   E
Sbjct: 1529 ELEKSKRALEQQV---EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE 1585

Query: 472  PIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQE--LEAENRLAQHTLQ 529
              +E   L           L + +    L++ S ++     ++ E  +EA N+     ++
Sbjct: 1586 QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK 1645

Query: 530  AL----------QSELDSLRADNIKLFEKIK 550
             L          Q EL+  RA   ++F + K
Sbjct: 1646 QLRKLQAQMKDYQRELEEARASRDEIFAQSK 1676



 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 82/411 (19%), Positives = 178/411 (43%), Gaps = 45/411 (10%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
            R  L++L+ EL AT      R + + Q+ K   E+  + +    E+ ++ +   ++  + 
Sbjct: 1545 RTQLEELEDELQATEDAKL-RLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA 1603

Query: 74   EIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETL 133
            E++      K+   A  +  K  ID+ D      L  Q++   +   ++  + +KL+  +
Sbjct: 1604 ELE---DERKQRALAVASKKKMEIDLKD------LEAQIEAANKARDEVIKQLRKLQAQM 1654

Query: 134  EEYNKEFAEVKNQEVTIKALKEKIREYEQTLKN-QAETIALEKEQKLQNDFAEKERKLQE 192
            ++Y +E  E +     I A   + +E E+ LK+ +AE +      +LQ + A  ER  + 
Sbjct: 1655 KDYQRELEEARASRDEIFA---QSKESEKKLKSLEAEIL------QLQEELASSERARRH 1705

Query: 193  TQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQ 252
             +       +E  +            ++ L D K + +       +E+E   +++E  N 
Sbjct: 1706 AEQERDELADEITNSASG--------KSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757

Query: 253  RAEVAQREAETLREQLS----------SANHSLQLASQIQKAPDVAIEVLTRSSLEVELA 302
            R      + +TL  +L+          +A   L+  ++  KA    +E   +S  +  ++
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATIS 1817

Query: 303  AKEREIAQLVEDVQ---RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKL-KGQA 358
            A E +I QL E ++   + +A+  KL   +  ++ ++  Q+  +     Q +E++ K  A
Sbjct: 1818 ALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANA 1877

Query: 359  DYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALR 409
              +++K++L   ++ E A    A  +   + L+    E N  L  E + L+
Sbjct: 1878 RMKQLKRQLE--EAEEEATRANASRRKLQRELDD-ATEANEGLSREVSTLK 1925



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 66/314 (21%), Positives = 122/314 (38%), Gaps = 36/314 (11%)

Query: 298  EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ 357
            E EL AK+ E+ ++ E   +++  L ++           +Q L  KN   +QL+ + +  
Sbjct: 851  EEELQAKDEELLKVKEKQTKVEGELEEMERKH-------QQLLEEKNILAEQLQAETELF 903

Query: 358  ADYEEVKKELNILK-SMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLS 416
            A+ EE++  L   K  +E    +     +  +    +L  + + +Q+    L     +  
Sbjct: 904  AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963

Query: 417  GRCAELQVRITEAVATATEQRELIARLEQDLS--IIQSIQRPDAEGAAEHRLEKIPEPIK 474
            G   +LQ+    A A   +  E I  LE   S  I +     D       +L +  E  K
Sbjct: 964  GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023

Query: 475  EATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSE 534
                +        S       ++  L      R+      ++L+ E    Q  +  LQ++
Sbjct: 1024 NLAKIRNKQEVMIS------DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077

Query: 535  LDSLRADNIKLFEKIKFLQSYPGRGSGSDDTEL----------RYSSQYEERLDPF---- 580
            +D L+   ++L +K + LQ    RG   DD  L             +Q  E  + F    
Sbjct: 1078 IDELK---LQLAKKEEELQGALARG---DDETLHKNNALKVVRELQAQIAELQEDFESEK 1131

Query: 581  SSFSKRERQRKYLS 594
            +S +K E+Q++ LS
Sbjct: 1132 ASRNKAEKQKRDLS 1145


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 125/538 (23%), Positives = 233/538 (43%), Gaps = 54/538 (10%)

Query: 13   KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
            K+F  Q L++  +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L
Sbjct: 2171 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2230

Query: 69   KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
             S + +++ LSK     EA    +  R  D        +  + LQ + +++  +  E  +
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2282

Query: 129  LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
            L    +E  +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L    
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2340

Query: 184  AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
             E+ R+LQE +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ 
Sbjct: 2341 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2388

Query: 244  MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSS------L 297
            + ++ RA  RAE   +      E++    H  +LA+Q +      +E+  + S      L
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448

Query: 298  EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ 357
               +A  ERE  +L ++ + LQ    +++     Q+ Q  Q L  + S L + +  L+ +
Sbjct: 2449 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQRE 2506

Query: 358  ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
               E+ K +L  L   E A ++    ++  +  + +  E+ R + S   A R  +    G
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565

Query: 418  RCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPI 473
                 Q  + +      +Q EL+A    RL + L +++   R     A  H  E     +
Sbjct: 2566 -VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTASQV 2620

Query: 474  KEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 527
                 L  G  A   PA+ A PE   D L   +S+QR +  A     E   RLAQ HT
Sbjct: 2621 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2677



 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 137/589 (23%), Positives = 230/589 (39%), Gaps = 103/589 (17%)

Query: 16   DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
            +LQQL++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1475

Query: 76   DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
             AL  R++EAEA      +          A  L +Q+Q + QR    E E          
Sbjct: 1476 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1526

Query: 126  ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
                 Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K + 
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1583

Query: 182  DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
             FAEK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1638

Query: 238  DEIEMIMTDLERANQRAEVAQREAETLREQLSSANH----------------SLQLASQI 281
            +E   +    E   Q+  +AQ EAE  +E+                        +L  Q 
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698

Query: 282  QKAPDVAIEVLT------------------RSSLEVELAAKEREIAQLVEDVQRLQASLT 323
            Q A   A + L                   R  LE ELA  +RE A   +  Q L+A L 
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758

Query: 324  KLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPSEG 380
            K+R      ++   +      ST ++ +++L+ +A  + E+ +E   L+++  E      
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818

Query: 381  AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELI 440
               +DAA+       E  R L  + AA+        G    L+     A+     + E +
Sbjct: 1819 LAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENERL 1866

Query: 441  ARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE-----GQ 495
             RL +D    ++ QR   E  A      I E + +             G + +      Q
Sbjct: 1867 RRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1922

Query: 496  VDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 539
            V+  +  + +  E+  A   ELE E       A+ TL++  Q+EL++ R
Sbjct: 1923 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1971



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 125/610 (20%), Positives = 230/610 (37%), Gaps = 80/610 (13%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
            R   +  Q   DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q 
Sbjct: 1136 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1190

Query: 74   EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
             +     R +E E     L  Y+   D         LG  LQ   +R   I+     ++Q
Sbjct: 1191 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1242

Query: 128  KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
             +RE L +      E++          EK+ E ++  K     I              K+
Sbjct: 1243 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1281

Query: 188  RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
             +LQ        +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L
Sbjct: 1282 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341

Query: 248  ERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEV------EL 301
             R  +   +A+++    RE+L+    +L+   Q+ +A   A     R + E+      E+
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401

Query: 302  AAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYE 361
              +E       +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++      
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR------ 1455

Query: 362  EVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLSGR 418
                   +   +E    +  G +   + L     E   + R  Q E   LR    D S R
Sbjct: 1456 ------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509

Query: 419  CAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAAEH 464
              + +V +      EA A   +QR L A  E  L   ++ +R            + A E 
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1569

Query: 465  RLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLA 524
                    ++   A F    A    +L E  V   ++ +  + ER   +  E E     A
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERAREEA 1627

Query: 525  QHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFS 581
            +  L+  Q   +E   LR    ++ ++    Q+   +     + E R   + EE+     
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687

Query: 582  SFSKRERQRK 591
              +++E +++
Sbjct: 1688 ELAEQELEKQ 1697



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 122/646 (18%), Positives = 257/646 (39%), Gaps = 98/646 (15%)

Query: 18   QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
            Q+  R+L         R    E++    ++Q  +  + T +    Q   +L   +GE +A
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ----QEQSVLDQLRGEAEA 2085

Query: 78   LSKRSKEAEAAFLNVYKRLIDVPDPVPALD-LGQQLQLKVQRLHDIETENQKLRETLEEY 136
              + ++EAE A +   +        V   + L Q  + + Q     +   +KLR+  E+ 
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2145

Query: 137  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
                A+ +       AL++K          QA    +EK +K       ++ ++++   +
Sbjct: 2146 AARRAQAEQA-----ALRQK----------QAADAEMEKHKKFAEQTLRQKAQVEQELTT 2190

Query: 197  TTSKLEEAEHKVQSLQTALEKTRT--------------ELFDLKTKYDEETTAK----AD 238
               +LEE +H+   L   L++ +               ELF ++ + +E +  K    A+
Sbjct: 2191 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2250

Query: 239  EIEMIMTDLERANQ-----------------RAEVAQREAETLREQLSSANHSLQ--LAS 279
               +I+ D +   +                 R  VA +EA  LR QL+  + + Q  LA 
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE 2309

Query: 280  QIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQ 339
            ++ K    A++  TR   E EL  +++E+AQ  E  +RLQ    ++ +  A +    ++ 
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRT 2367

Query: 340  LSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNR 399
            L A+       + +L+  A+ E +K     L+  E + ++    +DA +  +        
Sbjct: 2368 LEAER------QRQLEMSAEAERLK-----LRVAEMSRAQARAEEDAQRFRK-------- 2408

Query: 400  SLQSENAALRISNSDLSGR-----CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQ 454
              Q+E    ++  ++L+ +        L+++  ++   A   RE IA LE++   +Q   
Sbjct: 2409 --QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2466

Query: 455  RPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLS---IISSQRERFR 511
            +     + E +  +  + ++E  AL     +         + DSLL     I  ++ +  
Sbjct: 2467 KLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLLQRERFIEQEKAKLE 2517

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSS 571
               Q+  A+ +  +   Q  Q +++  R   +   E+ +  Q     G      EL+   
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577

Query: 572  QYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMART 617
            Q   + +   +   +  + +   L    +A L+    V ++++A T
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 127/576 (22%), Positives = 241/576 (41%), Gaps = 70/576 (12%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKS--- 70
            R + +Q +++       LA  Q E+  + ++  E   E  K     +R ++  LL S   
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-----VRAEMEVLLASKAR 1773

Query: 71   FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPAL--DLGQQLQLKVQRLHDIETENQK 128
             + E  + S++SK+   A    ++ L +    + AL  +  +Q QL  +   D   +  +
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE---DAARQRAE 1830

Query: 129  LRETLEEYNKEFAEVKNQEVTIK-ALKEKIREYEQTLKNQAETIALEK---EQKLQNDFA 184
                L E      E    +   + ALKEK  E E+ L+  AE  A ++   E++     A
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKA 1889

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            + E +L + + ++ S+LE  +  V+       +   E+  LK  +++    KA E+E+  
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELEL-- 1946

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAK 304
             +L R    AE   R  E  + +L +A    QLA++ ++    A E + +S    E AA+
Sbjct: 1947 -ELGRIRSNAEDTLRSKE--QAELEAARQR-QLAAEEERRRREAEERVQKSLAAEEEAAR 2002

Query: 305  EREIAQLVEDVQRLQASLT---KLRENSASQIS---QLEQQLSAKNSTLKQLEEKLKGQA 358
            +R+ A  +E+V+RL+A +    +LRE +  + +   QL Q+ + K    ++       Q 
Sbjct: 2003 QRKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060

Query: 359  DYEEVKKELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
              +E+++ L   +S ++    E    + AA+  E   ++  R  ++  +  ++  ++   
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAERLK 2118

Query: 418  RCAELQVRITEAVATATE------QRELIARLEQDLSIIQSIQRPDAE-----GAAEHRL 466
            + AE Q +       A E      ++E   R + + + ++  Q  DAE       AE  L
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178

Query: 467  EKIPEPIKEATALFYG------------------PAAPASGALPEGQVDSLLSIISSQRE 508
             +  +  +E T L                      A     A    QV+  L  +  Q E
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238

Query: 509  RFRARNQELEAENRL-----AQHTLQALQSELDSLR 539
                    +EAENR        +T + LQ E + ++
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 75/388 (19%), Positives = 163/388 (42%), Gaps = 56/388 (14%)

Query: 16   DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
            +L Q Q+EL   A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2330 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386

Query: 70   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443

Query: 127  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2444 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502

Query: 175  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562

Query: 212  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2622

Query: 272  NHSLQLASQIQKAPDVAIE-VLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLREN 328
              +L         P    E   +   L  +++A+  + A ++  E++QRL    T + E 
Sbjct: 2623 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2682

Query: 329  SASQISQ--LEQQLSAKNSTLKQLEEKL 354
            +  +  +  L+ + S     LK   EKL
Sbjct: 2683 ARREDVRHYLQGRSSIAGLLLKATNEKL 2710



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 87/462 (18%), Positives = 181/462 (39%), Gaps = 61/462 (13%)

Query: 125  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1074

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1075 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1129

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIE--------VLTR-S 295
              L++   +AE  Q   + LR++L  A    +   Q     DV +E        +L R  
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189

Query: 296  SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 338
            ++  +   ++RE+ QL                 ++D +R Q  +  +     +    + +
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1246

Query: 339  QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 396
            QL  + + L+++E   +   + +   K+ +N +K  E    +  A  +  A P       
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1300

Query: 397  KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 456
            K   +QS + ++     DL    +EL    ++ +   +   E + R+E++  + +  +  
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1357

Query: 457  DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 511
            + E  AE      +  ++ E   +A A     A      + E  V    + + +Q+++ R
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1416

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 553
            +  +EL+   + ++  +QA   + ++     +++ E+I+ ++
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 125/538 (23%), Positives = 233/538 (43%), Gaps = 54/538 (10%)

Query: 13   KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
            K+F  Q L++  +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L
Sbjct: 2175 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2234

Query: 69   KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
             S + +++ LSK     EA    +  R  D        +  + LQ + +++  +  E  +
Sbjct: 2235 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2286

Query: 129  LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
            L    +E  +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L    
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2344

Query: 184  AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
             E+ R+LQE +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ 
Sbjct: 2345 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2392

Query: 244  MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSS------L 297
            + ++ RA  RAE   +      E++    H  +LA+Q +      +E+  + S      L
Sbjct: 2393 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2452

Query: 298  EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ 357
               +A  ERE  +L ++ + LQ    +++     Q+ Q  Q L  + S L + +  L+ +
Sbjct: 2453 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQRE 2510

Query: 358  ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
               E+ K +L  L   E A ++    ++  +  + +  E+ R + S   A R  +    G
Sbjct: 2511 RFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2569

Query: 418  RCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPI 473
                 Q  + +      +Q EL+A    RL + L +++   R     A  H  E     +
Sbjct: 2570 -VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTASQV 2624

Query: 474  KEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 527
                 L  G  A   PA+ A PE   D L   +S+QR +  A     E   RLAQ HT
Sbjct: 2625 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2681



 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 137/589 (23%), Positives = 230/589 (39%), Gaps = 103/589 (17%)

Query: 16   DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
            +LQQL++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+
Sbjct: 1425 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1479

Query: 76   DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
             AL  R++EAEA      +          A  L +Q+Q + QR    E E          
Sbjct: 1480 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1530

Query: 126  ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
                 Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K + 
Sbjct: 1531 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1587

Query: 182  DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
             FAEK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1642

Query: 238  DEIEMIMTDLERANQRAEVAQREAETLREQLSSANH----------------SLQLASQI 281
            +E   +    E   Q+  +AQ EAE  +E+                        +L  Q 
Sbjct: 1643 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1702

Query: 282  QKAPDVAIEVLT------------------RSSLEVELAAKEREIAQLVEDVQRLQASLT 323
            Q A   A + L                   R  LE ELA  +RE A   +  Q L+A L 
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762

Query: 324  KLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPSEG 380
            K+R      ++   +      ST ++ +++L+ +A  + E+ +E   L+++  E      
Sbjct: 1763 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1822

Query: 381  AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELI 440
               +DAA+       E  R L  + AA+        G    L+     A+     + E +
Sbjct: 1823 LAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENERL 1870

Query: 441  ARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE-----GQ 495
             RL +D    ++ QR   E  A      I E + +             G + +      Q
Sbjct: 1871 RRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1926

Query: 496  VDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 539
            V+  +  + +  E+  A   ELE E       A+ TL++  Q+EL++ R
Sbjct: 1927 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1975



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 125/610 (20%), Positives = 230/610 (37%), Gaps = 80/610 (13%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
            R   +  Q   DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q 
Sbjct: 1140 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1194

Query: 74   EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
             +     R +E E     L  Y+   D         LG  LQ   +R   I+     ++Q
Sbjct: 1195 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1246

Query: 128  KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
             +RE L +      E++          EK+ E ++  K     I              K+
Sbjct: 1247 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1285

Query: 188  RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
             +LQ        +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L
Sbjct: 1286 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1345

Query: 248  ERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEV------EL 301
             R  +   +A+++    RE+L+    +L+   Q+ +A   A     R + E+      E+
Sbjct: 1346 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1405

Query: 302  AAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYE 361
              +E       +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++      
Sbjct: 1406 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR------ 1459

Query: 362  EVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLSGR 418
                   +   +E    +  G +   + L     E   + R  Q E   LR    D S R
Sbjct: 1460 ------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513

Query: 419  CAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAAEH 464
              + +V +      EA A   +QR L A  E  L   ++ +R            + A E 
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1573

Query: 465  RLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLA 524
                    ++   A F    A    +L E  V   ++ +  + ER   +  E E     A
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERAREEA 1631

Query: 525  QHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFS 581
            +  L+  Q   +E   LR    ++ ++    Q+   +     + E R   + EE+     
Sbjct: 1632 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1691

Query: 582  SFSKRERQRK 591
              +++E +++
Sbjct: 1692 ELAEQELEKQ 1701



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 122/646 (18%), Positives = 257/646 (39%), Gaps = 98/646 (15%)

Query: 18   QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
            Q+  R+L         R    E++    ++Q  +  + T +    Q   +L   +GE +A
Sbjct: 2034 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ----QEQSVLDQLRGEAEA 2089

Query: 78   LSKRSKEAEAAFLNVYKRLIDVPDPVPALD-LGQQLQLKVQRLHDIETENQKLRETLEEY 136
              + ++EAE A +   +        V   + L Q  + + Q     +   +KLR+  E+ 
Sbjct: 2090 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2149

Query: 137  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
                A+ +       AL++K          QA    +EK +K       ++ ++++   +
Sbjct: 2150 AARRAQAEQA-----ALRQK----------QAADAEMEKHKKFAEQTLRQKAQVEQELTT 2194

Query: 197  TTSKLEEAEHKVQSLQTALEKTRT--------------ELFDLKTKYDEETTAK----AD 238
               +LEE +H+   L   L++ +               ELF ++ + +E +  K    A+
Sbjct: 2195 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2254

Query: 239  EIEMIMTDLERANQ-----------------RAEVAQREAETLREQLSSANHSLQ--LAS 279
               +I+ D +   +                 R  VA +EA  LR QL+  + + Q  LA 
Sbjct: 2255 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE 2313

Query: 280  QIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQ 339
            ++ K    A++  TR   E EL  +++E+AQ  E  +RLQ    ++ +  A +    ++ 
Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRT 2371

Query: 340  LSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNR 399
            L A+       + +L+  A+ E +K     L+  E + ++    +DA +  +        
Sbjct: 2372 LEAER------QRQLEMSAEAERLK-----LRVAEMSRAQARAEEDAQRFRK-------- 2412

Query: 400  SLQSENAALRISNSDLSGR-----CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQ 454
              Q+E    ++  ++L+ +        L+++  ++   A   RE IA LE++   +Q   
Sbjct: 2413 --QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2470

Query: 455  RPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLS---IISSQRERFR 511
            +     + E +  +  + ++E  AL     +         + DSLL     I  ++ +  
Sbjct: 2471 KLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLLQRERFIEQEKAKLE 2521

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSS 571
               Q+  A+ +  +   Q  Q +++  R   +   E+ +  Q     G      EL+   
Sbjct: 2522 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2581

Query: 572  QYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMART 617
            Q   + +   +   +  + +   L    +A L+    V ++++A T
Sbjct: 2582 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2627



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 127/576 (22%), Positives = 241/576 (41%), Gaps = 70/576 (12%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKS--- 70
            R + +Q +++       LA  Q E+  + ++  E   E  K     +R ++  LL S   
Sbjct: 1723 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-----VRAEMEVLLASKAR 1777

Query: 71   FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPAL--DLGQQLQLKVQRLHDIETENQK 128
             + E  + S++SK+   A    ++ L +    + AL  +  +Q QL  +   D   +  +
Sbjct: 1778 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE---DAARQRAE 1834

Query: 129  LRETLEEYNKEFAEVKNQEVTIK-ALKEKIREYEQTLKNQAETIALEK---EQKLQNDFA 184
                L E      E    +   + ALKEK  E E+ L+  AE  A ++   E++     A
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKA 1893

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            + E +L + + ++ S+LE  +  V+       +   E+  LK  +++    KA E+E+  
Sbjct: 1894 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELEL-- 1950

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAK 304
             +L R    AE   R  E  + +L +A    QLA++ ++    A E + +S    E AA+
Sbjct: 1951 -ELGRIRSNAEDTLRSKE--QAELEAARQR-QLAAEEERRRREAEERVQKSLAAEEEAAR 2006

Query: 305  EREIAQLVEDVQRLQASLT---KLRENSASQIS---QLEQQLSAKNSTLKQLEEKLKGQA 358
            +R+ A  +E+V+RL+A +    +LRE +  + +   QL Q+ + K    ++       Q 
Sbjct: 2007 QRKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2064

Query: 359  DYEEVKKELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
              +E+++ L   +S ++    E    + AA+  E   ++  R  ++  +  ++  ++   
Sbjct: 2065 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAERLK 2122

Query: 418  RCAELQVRITEAVATATE------QRELIARLEQDLSIIQSIQRPDAE-----GAAEHRL 466
            + AE Q +       A E      ++E   R + + + ++  Q  DAE       AE  L
Sbjct: 2123 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182

Query: 467  EKIPEPIKEATALFYG------------------PAAPASGALPEGQVDSLLSIISSQRE 508
             +  +  +E T L                      A     A    QV+  L  +  Q E
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2242

Query: 509  RFRARNQELEAENRL-----AQHTLQALQSELDSLR 539
                    +EAENR        +T + LQ E + ++
Sbjct: 2243 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2278



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 75/388 (19%), Positives = 163/388 (42%), Gaps = 56/388 (14%)

Query: 16   DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
            +L Q Q+EL   A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2334 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2390

Query: 70   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2391 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2447

Query: 127  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2448 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2506

Query: 175  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2507 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2566

Query: 212  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2567 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2626

Query: 272  NHSLQLASQIQKAPDVAIE-VLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLREN 328
              +L         P    E   +   L  +++A+  + A ++  E++QRL    T + E 
Sbjct: 2627 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2686

Query: 329  SASQISQ--LEQQLSAKNSTLKQLEEKL 354
            +  +  +  L+ + S     LK   EKL
Sbjct: 2687 ARREDVRHYLQGRSSIAGLLLKATNEKL 2714



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 87/462 (18%), Positives = 181/462 (39%), Gaps = 61/462 (13%)

Query: 125  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 1029 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1078

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1079 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1133

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIE--------VLTR-S 295
              L++   +AE  Q   + LR++L  A    +   Q     DV +E        +L R  
Sbjct: 1134 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1193

Query: 296  SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 338
            ++  +   ++RE+ QL                 ++D +R Q  +  +     +    + +
Sbjct: 1194 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1250

Query: 339  QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 396
            QL  + + L+++E   +   + +   K+ +N +K  E    +  A  +  A P       
Sbjct: 1251 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1304

Query: 397  KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 456
            K   +QS + ++     DL    +EL    ++ +   +   E + R+E++  + +  +  
Sbjct: 1305 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1361

Query: 457  DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 511
            + E  AE      +  ++ E   +A A     A      + E  V    + + +Q+++ R
Sbjct: 1362 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1420

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 553
            +  +EL+   + ++  +QA   + ++     +++ E+I+ ++
Sbjct: 1421 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 125/538 (23%), Positives = 233/538 (43%), Gaps = 54/538 (10%)

Query: 13   KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
            K+F  Q L++  +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L
Sbjct: 2171 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2230

Query: 69   KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
             S + +++ LSK     EA    +  R  D        +  + LQ + +++  +  E  +
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2282

Query: 129  LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
            L    +E  +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L    
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2340

Query: 184  AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
             E+ R+LQE +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ 
Sbjct: 2341 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2388

Query: 244  MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSS------L 297
            + ++ RA  RAE   +      E++    H  +LA+Q +      +E+  + S      L
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448

Query: 298  EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ 357
               +A  ERE  +L ++ + LQ    +++     Q+ Q  Q L  + S L + +  L+ +
Sbjct: 2449 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQRE 2506

Query: 358  ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
               E+ K +L  L   E A ++    ++  +  + +  E+ R + S   A R  +    G
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565

Query: 418  RCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPI 473
                 Q  + +      +Q EL+A    RL + L +++   R     A  H  E     +
Sbjct: 2566 -VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTASQV 2620

Query: 474  KEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 527
                 L  G  A   PA+ A PE   D L   +S+QR +  A     E   RLAQ HT
Sbjct: 2621 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2677



 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 137/589 (23%), Positives = 230/589 (39%), Gaps = 103/589 (17%)

Query: 16   DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
            +LQQL++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1475

Query: 76   DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
             AL  R++EAEA      +          A  L +Q+Q + QR    E E          
Sbjct: 1476 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1526

Query: 126  ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
                 Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K + 
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1583

Query: 182  DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
             FAEK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1638

Query: 238  DEIEMIMTDLERANQRAEVAQREAETLREQLSSANH----------------SLQLASQI 281
            +E   +    E   Q+  +AQ EAE  +E+                        +L  Q 
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698

Query: 282  QKAPDVAIEVLT------------------RSSLEVELAAKEREIAQLVEDVQRLQASLT 323
            Q A   A + L                   R  LE ELA  +RE A   +  Q L+A L 
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758

Query: 324  KLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPSEG 380
            K+R      ++   +      ST ++ +++L+ +A  + E+ +E   L+++  E      
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818

Query: 381  AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELI 440
               +DAA+       E  R L  + AA+        G    L+     A+     + E +
Sbjct: 1819 LAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENERL 1866

Query: 441  ARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE-----GQ 495
             RL +D    ++ QR   E  A      I E + +             G + +      Q
Sbjct: 1867 RRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1922

Query: 496  VDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 539
            V+  +  + +  E+  A   ELE E       A+ TL++  Q+EL++ R
Sbjct: 1923 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1971



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 125/610 (20%), Positives = 230/610 (37%), Gaps = 80/610 (13%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
            R   +  Q   DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q 
Sbjct: 1136 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1190

Query: 74   EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
             +     R +E E     L  Y+   D         LG  LQ   +R   I+     ++Q
Sbjct: 1191 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1242

Query: 128  KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
             +RE L +      E++          EK+ E ++  K     I              K+
Sbjct: 1243 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1281

Query: 188  RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
             +LQ        +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L
Sbjct: 1282 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341

Query: 248  ERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEV------EL 301
             R  +   +A+++    RE+L+    +L+   Q+ +A   A     R + E+      E+
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401

Query: 302  AAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYE 361
              +E       +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++      
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR------ 1455

Query: 362  EVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLSGR 418
                   +   +E    +  G +   + L     E   + R  Q E   LR    D S R
Sbjct: 1456 ------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509

Query: 419  CAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAAEH 464
              + +V +      EA A   +QR L A  E  L   ++ +R            + A E 
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1569

Query: 465  RLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLA 524
                    ++   A F    A    +L E  V   ++ +  + ER   +  E E     A
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERAREEA 1627

Query: 525  QHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFS 581
            +  L+  Q   +E   LR    ++ ++    Q+   +     + E R   + EE+     
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687

Query: 582  SFSKRERQRK 591
              +++E +++
Sbjct: 1688 ELAEQELEKQ 1697



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 122/646 (18%), Positives = 257/646 (39%), Gaps = 98/646 (15%)

Query: 18   QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
            Q+  R+L         R    E++    ++Q  +  + T +    Q   +L   +GE +A
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ----QEQSVLDQLRGEAEA 2085

Query: 78   LSKRSKEAEAAFLNVYKRLIDVPDPVPALD-LGQQLQLKVQRLHDIETENQKLRETLEEY 136
              + ++EAE A +   +        V   + L Q  + + Q     +   +KLR+  E+ 
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2145

Query: 137  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
                A+ +       AL++K          QA    +EK +K       ++ ++++   +
Sbjct: 2146 AARRAQAEQA-----ALRQK----------QAADAEMEKHKKFAEQTLRQKAQVEQELTT 2190

Query: 197  TTSKLEEAEHKVQSLQTALEKTRT--------------ELFDLKTKYDEETTAK----AD 238
               +LEE +H+   L   L++ +               ELF ++ + +E +  K    A+
Sbjct: 2191 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2250

Query: 239  EIEMIMTDLERANQ-----------------RAEVAQREAETLREQLSSANHSLQ--LAS 279
               +I+ D +   +                 R  VA +EA  LR QL+  + + Q  LA 
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE 2309

Query: 280  QIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQ 339
            ++ K    A++  TR   E EL  +++E+AQ  E  +RLQ    ++ +  A +    ++ 
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRT 2367

Query: 340  LSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNR 399
            L A+       + +L+  A+ E +K     L+  E + ++    +DA +  +        
Sbjct: 2368 LEAER------QRQLEMSAEAERLK-----LRVAEMSRAQARAEEDAQRFRK-------- 2408

Query: 400  SLQSENAALRISNSDLSGR-----CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQ 454
              Q+E    ++  ++L+ +        L+++  ++   A   RE IA LE++   +Q   
Sbjct: 2409 --QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2466

Query: 455  RPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLS---IISSQRERFR 511
            +     + E +  +  + ++E  AL     +         + DSLL     I  ++ +  
Sbjct: 2467 KLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLLQRERFIEQEKAKLE 2517

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSS 571
               Q+  A+ +  +   Q  Q +++  R   +   E+ +  Q     G      EL+   
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577

Query: 572  QYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMART 617
            Q   + +   +   +  + +   L    +A L+    V ++++A T
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 127/576 (22%), Positives = 241/576 (41%), Gaps = 70/576 (12%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKS--- 70
            R + +Q +++       LA  Q E+  + ++  E   E  K     +R ++  LL S   
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-----VRAEMEVLLASKAR 1773

Query: 71   FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPAL--DLGQQLQLKVQRLHDIETENQK 128
             + E  + S++SK+   A    ++ L +    + AL  +  +Q QL  +   D   +  +
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE---DAARQRAE 1830

Query: 129  LRETLEEYNKEFAEVKNQEVTIK-ALKEKIREYEQTLKNQAETIALEK---EQKLQNDFA 184
                L E      E    +   + ALKEK  E E+ L+  AE  A ++   E++     A
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKA 1889

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            + E +L + + ++ S+LE  +  V+       +   E+  LK  +++    KA E+E+  
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELEL-- 1946

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAK 304
             +L R    AE   R  E  + +L +A    QLA++ ++    A E + +S    E AA+
Sbjct: 1947 -ELGRIRSNAEDTLRSKE--QAELEAARQR-QLAAEEERRRREAEERVQKSLAAEEEAAR 2002

Query: 305  EREIAQLVEDVQRLQASLT---KLRENSASQIS---QLEQQLSAKNSTLKQLEEKLKGQA 358
            +R+ A  +E+V+RL+A +    +LRE +  + +   QL Q+ + K    ++       Q 
Sbjct: 2003 QRKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060

Query: 359  DYEEVKKELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
              +E+++ L   +S ++    E    + AA+  E   ++  R  ++  +  ++  ++   
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAERLK 2118

Query: 418  RCAELQVRITEAVATATE------QRELIARLEQDLSIIQSIQRPDAE-----GAAEHRL 466
            + AE Q +       A E      ++E   R + + + ++  Q  DAE       AE  L
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178

Query: 467  EKIPEPIKEATALFYG------------------PAAPASGALPEGQVDSLLSIISSQRE 508
             +  +  +E T L                      A     A    QV+  L  +  Q E
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238

Query: 509  RFRARNQELEAENRL-----AQHTLQALQSELDSLR 539
                    +EAENR        +T + LQ E + ++
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 75/388 (19%), Positives = 163/388 (42%), Gaps = 56/388 (14%)

Query: 16   DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
            +L Q Q+EL   A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2330 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386

Query: 70   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443

Query: 127  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2444 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502

Query: 175  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562

Query: 212  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2622

Query: 272  NHSLQLASQIQKAPDVAIE-VLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLREN 328
              +L         P    E   +   L  +++A+  + A ++  E++QRL    T + E 
Sbjct: 2623 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2682

Query: 329  SASQISQ--LEQQLSAKNSTLKQLEEKL 354
            +  +  +  L+ + S     LK   EKL
Sbjct: 2683 ARREDVRHYLQGRSSIAGLLLKATNEKL 2710



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 87/462 (18%), Positives = 181/462 (39%), Gaps = 61/462 (13%)

Query: 125  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1074

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1075 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1129

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIE--------VLTR-S 295
              L++   +AE  Q   + LR++L  A    +   Q     DV +E        +L R  
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189

Query: 296  SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 338
            ++  +   ++RE+ QL                 ++D +R Q  +  +     +    + +
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1246

Query: 339  QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 396
            QL  + + L+++E   +   + +   K+ +N +K  E    +  A  +  A P       
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1300

Query: 397  KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 456
            K   +QS + ++     DL    +EL    ++ +   +   E + R+E++  + +  +  
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1357

Query: 457  DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 511
            + E  AE      +  ++ E   +A A     A      + E  V    + + +Q+++ R
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1416

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 553
            +  +EL+   + ++  +QA   + ++     +++ E+I+ ++
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 125/538 (23%), Positives = 233/538 (43%), Gaps = 54/538 (10%)

Query: 13   KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
            K+F  Q L++  +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L
Sbjct: 2139 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2198

Query: 69   KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
             S + +++ LSK     EA    +  R  D        +  + LQ + +++  +  E  +
Sbjct: 2199 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2250

Query: 129  LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
            L    +E  +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L    
Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2308

Query: 184  AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
             E+ R+LQE +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ 
Sbjct: 2309 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2356

Query: 244  MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSS------L 297
            + ++ RA  RAE   +      E++    H  +LA+Q +      +E+  + S      L
Sbjct: 2357 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2416

Query: 298  EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ 357
               +A  ERE  +L ++ + LQ    +++     Q+ Q  Q L  + S L + +  L+ +
Sbjct: 2417 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQRE 2474

Query: 358  ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
               E+ K +L  L   E A ++    ++  +  + +  E+ R + S   A R  +    G
Sbjct: 2475 RFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2533

Query: 418  RCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPI 473
                 Q  + +      +Q EL+A    RL + L +++   R     A  H  E     +
Sbjct: 2534 -VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTASQV 2588

Query: 474  KEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 527
                 L  G  A   PA+ A PE   D L   +S+QR +  A     E   RLAQ HT
Sbjct: 2589 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2645



 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 137/589 (23%), Positives = 230/589 (39%), Gaps = 103/589 (17%)

Query: 16   DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
            +LQQL++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+
Sbjct: 1389 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1443

Query: 76   DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
             AL  R++EAEA      +          A  L +Q+Q + QR    E E          
Sbjct: 1444 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1494

Query: 126  ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
                 Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K + 
Sbjct: 1495 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1551

Query: 182  DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
             FAEK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1606

Query: 238  DEIEMIMTDLERANQRAEVAQREAETLREQLSSANH----------------SLQLASQI 281
            +E   +    E   Q+  +AQ EAE  +E+                        +L  Q 
Sbjct: 1607 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1666

Query: 282  QKAPDVAIEVLT------------------RSSLEVELAAKEREIAQLVEDVQRLQASLT 323
            Q A   A + L                   R  LE ELA  +RE A   +  Q L+A L 
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726

Query: 324  KLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPSEG 380
            K+R      ++   +      ST ++ +++L+ +A  + E+ +E   L+++  E      
Sbjct: 1727 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1786

Query: 381  AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELI 440
               +DAA+       E  R L  + AA+        G    L+     A+     + E +
Sbjct: 1787 LAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENERL 1834

Query: 441  ARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE-----GQ 495
             RL +D    ++ QR   E  A      I E + +             G + +      Q
Sbjct: 1835 RRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1890

Query: 496  VDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 539
            V+  +  + +  E+  A   ELE E       A+ TL++  Q+EL++ R
Sbjct: 1891 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1939



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 125/610 (20%), Positives = 230/610 (37%), Gaps = 80/610 (13%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
            R   +  Q   DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q 
Sbjct: 1104 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1158

Query: 74   EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
             +     R +E E     L  Y+   D         LG  LQ   +R   I+     ++Q
Sbjct: 1159 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1210

Query: 128  KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
             +RE L +      E++          EK+ E ++  K     I              K+
Sbjct: 1211 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1249

Query: 188  RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
             +LQ        +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L
Sbjct: 1250 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1309

Query: 248  ERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEV------EL 301
             R  +   +A+++    RE+L+    +L+   Q+ +A   A     R + E+      E+
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1369

Query: 302  AAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYE 361
              +E       +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++      
Sbjct: 1370 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR------ 1423

Query: 362  EVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLSGR 418
                   +   +E    +  G +   + L     E   + R  Q E   LR    D S R
Sbjct: 1424 ------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477

Query: 419  CAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAAEH 464
              + +V +      EA A   +QR L A  E  L   ++ +R            + A E 
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1537

Query: 465  RLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLA 524
                    ++   A F    A    +L E  V   ++ +  + ER   +  E E     A
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERAREEA 1595

Query: 525  QHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFS 581
            +  L+  Q   +E   LR    ++ ++    Q+   +     + E R   + EE+     
Sbjct: 1596 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1655

Query: 582  SFSKRERQRK 591
              +++E +++
Sbjct: 1656 ELAEQELEKQ 1665



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 122/646 (18%), Positives = 257/646 (39%), Gaps = 98/646 (15%)

Query: 18   QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
            Q+  R+L         R    E++    ++Q  +  + T +    Q   +L   +GE +A
Sbjct: 1998 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ----QEQSVLDQLRGEAEA 2053

Query: 78   LSKRSKEAEAAFLNVYKRLIDVPDPVPALD-LGQQLQLKVQRLHDIETENQKLRETLEEY 136
              + ++EAE A +   +        V   + L Q  + + Q     +   +KLR+  E+ 
Sbjct: 2054 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2113

Query: 137  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
                A+ +       AL++K          QA    +EK +K       ++ ++++   +
Sbjct: 2114 AARRAQAEQA-----ALRQK----------QAADAEMEKHKKFAEQTLRQKAQVEQELTT 2158

Query: 197  TTSKLEEAEHKVQSLQTALEKTRT--------------ELFDLKTKYDEETTAK----AD 238
               +LEE +H+   L   L++ +               ELF ++ + +E +  K    A+
Sbjct: 2159 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2218

Query: 239  EIEMIMTDLERANQ-----------------RAEVAQREAETLREQLSSANHSLQ--LAS 279
               +I+ D +   +                 R  VA +EA  LR QL+  + + Q  LA 
Sbjct: 2219 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE 2277

Query: 280  QIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQ 339
            ++ K    A++  TR   E EL  +++E+AQ  E  +RLQ    ++ +  A +    ++ 
Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRT 2335

Query: 340  LSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNR 399
            L A+       + +L+  A+ E +K     L+  E + ++    +DA +  +        
Sbjct: 2336 LEAER------QRQLEMSAEAERLK-----LRVAEMSRAQARAEEDAQRFRK-------- 2376

Query: 400  SLQSENAALRISNSDLSGR-----CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQ 454
              Q+E    ++  ++L+ +        L+++  ++   A   RE IA LE++   +Q   
Sbjct: 2377 --QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2434

Query: 455  RPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLS---IISSQRERFR 511
            +     + E +  +  + ++E  AL     +         + DSLL     I  ++ +  
Sbjct: 2435 KLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLLQRERFIEQEKAKLE 2485

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSS 571
               Q+  A+ +  +   Q  Q +++  R   +   E+ +  Q     G      EL+   
Sbjct: 2486 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2545

Query: 572  QYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMART 617
            Q   + +   +   +  + +   L    +A L+    V ++++A T
Sbjct: 2546 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2591



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 127/576 (22%), Positives = 241/576 (41%), Gaps = 70/576 (12%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKS--- 70
            R + +Q +++       LA  Q E+  + ++  E   E  K     +R ++  LL S   
Sbjct: 1687 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-----VRAEMEVLLASKAR 1741

Query: 71   FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPAL--DLGQQLQLKVQRLHDIETENQK 128
             + E  + S++SK+   A    ++ L +    + AL  +  +Q QL  +   D   +  +
Sbjct: 1742 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE---DAARQRAE 1798

Query: 129  LRETLEEYNKEFAEVKNQEVTIK-ALKEKIREYEQTLKNQAETIALEK---EQKLQNDFA 184
                L E      E    +   + ALKEK  E E+ L+  AE  A ++   E++     A
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKA 1857

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            + E +L + + ++ S+LE  +  V+       +   E+  LK  +++    KA E+E+  
Sbjct: 1858 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELEL-- 1914

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAK 304
             +L R    AE   R  E  + +L +A    QLA++ ++    A E + +S    E AA+
Sbjct: 1915 -ELGRIRSNAEDTLRSKE--QAELEAARQR-QLAAEEERRRREAEERVQKSLAAEEEAAR 1970

Query: 305  EREIAQLVEDVQRLQASLT---KLRENSASQIS---QLEQQLSAKNSTLKQLEEKLKGQA 358
            +R+ A  +E+V+RL+A +    +LRE +  + +   QL Q+ + K    ++       Q 
Sbjct: 1971 QRKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2028

Query: 359  DYEEVKKELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
              +E+++ L   +S ++    E    + AA+  E   ++  R  ++  +  ++  ++   
Sbjct: 2029 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAERLK 2086

Query: 418  RCAELQVRITEAVATATE------QRELIARLEQDLSIIQSIQRPDAE-----GAAEHRL 466
            + AE Q +       A E      ++E   R + + + ++  Q  DAE       AE  L
Sbjct: 2087 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146

Query: 467  EKIPEPIKEATALFYG------------------PAAPASGALPEGQVDSLLSIISSQRE 508
             +  +  +E T L                      A     A    QV+  L  +  Q E
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2206

Query: 509  RFRARNQELEAENRL-----AQHTLQALQSELDSLR 539
                    +EAENR        +T + LQ E + ++
Sbjct: 2207 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2242



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 75/388 (19%), Positives = 163/388 (42%), Gaps = 56/388 (14%)

Query: 16   DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
            +L Q Q+EL   A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2298 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2354

Query: 70   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2355 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2411

Query: 127  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2412 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2470

Query: 175  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2471 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2530

Query: 212  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2531 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2590

Query: 272  NHSLQLASQIQKAPDVAIE-VLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLREN 328
              +L         P    E   +   L  +++A+  + A ++  E++QRL    T + E 
Sbjct: 2591 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2650

Query: 329  SASQISQ--LEQQLSAKNSTLKQLEEKL 354
            +  +  +  L+ + S     LK   EKL
Sbjct: 2651 ARREDVRHYLQGRSSIAGLLLKATNEKL 2678



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 87/462 (18%), Positives = 181/462 (39%), Gaps = 61/462 (13%)

Query: 125  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 993  EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1042

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1043 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1097

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIE--------VLTR-S 295
              L++   +AE  Q   + LR++L  A    +   Q     DV +E        +L R  
Sbjct: 1098 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1157

Query: 296  SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 338
            ++  +   ++RE+ QL                 ++D +R Q  +  +     +    + +
Sbjct: 1158 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1214

Query: 339  QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 396
            QL  + + L+++E   +   + +   K+ +N +K  E    +  A  +  A P       
Sbjct: 1215 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1268

Query: 397  KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 456
            K   +QS + ++     DL    +EL    ++ +   +   E + R+E++  + +  +  
Sbjct: 1269 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1325

Query: 457  DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 511
            + E  AE      +  ++ E   +A A     A      + E  V    + + +Q+++ R
Sbjct: 1326 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1384

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 553
            +  +EL+   + ++  +QA   + ++     +++ E+I+ ++
Sbjct: 1385 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 125/538 (23%), Positives = 233/538 (43%), Gaps = 54/538 (10%)

Query: 13   KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
            K+F  Q L++  +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L
Sbjct: 2308 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2367

Query: 69   KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
             S + +++ LSK     EA    +  R  D        +  + LQ + +++  +  E  +
Sbjct: 2368 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2419

Query: 129  LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
            L    +E  +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L    
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2477

Query: 184  AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
             E+ R+LQE +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ 
Sbjct: 2478 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2525

Query: 244  MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSS------L 297
            + ++ RA  RAE   +      E++    H  +LA+Q +      +E+  + S      L
Sbjct: 2526 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2585

Query: 298  EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ 357
               +A  ERE  +L ++ + LQ    +++     Q+ Q  Q L  + S L + +  L+ +
Sbjct: 2586 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQRE 2643

Query: 358  ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
               E+ K +L  L   E A ++    ++  +  + +  E+ R + S   A R  +    G
Sbjct: 2644 RFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2702

Query: 418  RCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPI 473
                 Q  + +      +Q EL+A    RL + L +++   R     A  H  E     +
Sbjct: 2703 -VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTASQV 2757

Query: 474  KEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 527
                 L  G  A   PA+ A PE   D L   +S+QR +  A     E   RLAQ HT
Sbjct: 2758 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2814



 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 137/589 (23%), Positives = 230/589 (39%), Gaps = 103/589 (17%)

Query: 16   DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
            +LQQL++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+
Sbjct: 1558 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1612

Query: 76   DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
             AL  R++EAEA      +          A  L +Q+Q + QR    E E          
Sbjct: 1613 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1663

Query: 126  ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
                 Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K + 
Sbjct: 1664 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1720

Query: 182  DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
             FAEK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1775

Query: 238  DEIEMIMTDLERANQRAEVAQREAETLREQLSSANH----------------SLQLASQI 281
            +E   +    E   Q+  +AQ EAE  +E+                        +L  Q 
Sbjct: 1776 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835

Query: 282  QKAPDVAIEVLT------------------RSSLEVELAAKEREIAQLVEDVQRLQASLT 323
            Q A   A + L                   R  LE ELA  +RE A   +  Q L+A L 
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895

Query: 324  KLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPSEG 380
            K+R      ++   +      ST ++ +++L+ +A  + E+ +E   L+++  E      
Sbjct: 1896 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1955

Query: 381  AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELI 440
               +DAA+       E  R L  + AA+        G    L+     A+     + E +
Sbjct: 1956 LAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENERL 2003

Query: 441  ARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE-----GQ 495
             RL +D    ++ QR   E  A      I E + +             G + +      Q
Sbjct: 2004 RRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 2059

Query: 496  VDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 539
            V+  +  + +  E+  A   ELE E       A+ TL++  Q+EL++ R
Sbjct: 2060 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 2108



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 125/610 (20%), Positives = 230/610 (37%), Gaps = 80/610 (13%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
            R   +  Q   DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q 
Sbjct: 1273 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1327

Query: 74   EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
             +     R +E E     L  Y+   D         LG  LQ   +R   I+     ++Q
Sbjct: 1328 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1379

Query: 128  KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
             +RE L +      E++          EK+ E ++  K     I              K+
Sbjct: 1380 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1418

Query: 188  RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
             +LQ        +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L
Sbjct: 1419 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1478

Query: 248  ERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEV------EL 301
             R  +   +A+++    RE+L+    +L+   Q+ +A   A     R + E+      E+
Sbjct: 1479 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1538

Query: 302  AAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYE 361
              +E       +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++      
Sbjct: 1539 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR------ 1592

Query: 362  EVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLSGR 418
                   +   +E    +  G +   + L     E   + R  Q E   LR    D S R
Sbjct: 1593 ------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646

Query: 419  CAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAAEH 464
              + +V +      EA A   +QR L A  E  L   ++ +R            + A E 
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1706

Query: 465  RLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLA 524
                    ++   A F    A    +L E  V   ++ +  + ER   +  E E     A
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERAREEA 1764

Query: 525  QHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFS 581
            +  L+  Q   +E   LR    ++ ++    Q+   +     + E R   + EE+     
Sbjct: 1765 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1824

Query: 582  SFSKRERQRK 591
              +++E +++
Sbjct: 1825 ELAEQELEKQ 1834



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 122/646 (18%), Positives = 257/646 (39%), Gaps = 98/646 (15%)

Query: 18   QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
            Q+  R+L         R    E++    ++Q  +  + T +    Q   +L   +GE +A
Sbjct: 2167 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ----QEQSVLDQLRGEAEA 2222

Query: 78   LSKRSKEAEAAFLNVYKRLIDVPDPVPALD-LGQQLQLKVQRLHDIETENQKLRETLEEY 136
              + ++EAE A +   +        V   + L Q  + + Q     +   +KLR+  E+ 
Sbjct: 2223 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2282

Query: 137  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
                A+ +       AL++K          QA    +EK +K       ++ ++++   +
Sbjct: 2283 AARRAQAEQA-----ALRQK----------QAADAEMEKHKKFAEQTLRQKAQVEQELTT 2327

Query: 197  TTSKLEEAEHKVQSLQTALEKTRT--------------ELFDLKTKYDEETTAK----AD 238
               +LEE +H+   L   L++ +               ELF ++ + +E +  K    A+
Sbjct: 2328 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2387

Query: 239  EIEMIMTDLERANQ-----------------RAEVAQREAETLREQLSSANHSLQ--LAS 279
               +I+ D +   +                 R  VA +EA  LR QL+  + + Q  LA 
Sbjct: 2388 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE 2446

Query: 280  QIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQ 339
            ++ K    A++  TR   E EL  +++E+AQ  E  +RLQ    ++ +  A +    ++ 
Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRT 2504

Query: 340  LSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNR 399
            L A+       + +L+  A+ E +K     L+  E + ++    +DA +  +        
Sbjct: 2505 LEAER------QRQLEMSAEAERLK-----LRVAEMSRAQARAEEDAQRFRK-------- 2545

Query: 400  SLQSENAALRISNSDLSGR-----CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQ 454
              Q+E    ++  ++L+ +        L+++  ++   A   RE IA LE++   +Q   
Sbjct: 2546 --QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2603

Query: 455  RPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLS---IISSQRERFR 511
            +     + E +  +  + ++E  AL     +         + DSLL     I  ++ +  
Sbjct: 2604 KLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLLQRERFIEQEKAKLE 2654

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSS 571
               Q+  A+ +  +   Q  Q +++  R   +   E+ +  Q     G      EL+   
Sbjct: 2655 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714

Query: 572  QYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMART 617
            Q   + +   +   +  + +   L    +A L+    V ++++A T
Sbjct: 2715 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2760



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 127/576 (22%), Positives = 241/576 (41%), Gaps = 70/576 (12%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKS--- 70
            R + +Q +++       LA  Q E+  + ++  E   E  K     +R ++  LL S   
Sbjct: 1856 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-----VRAEMEVLLASKAR 1910

Query: 71   FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPAL--DLGQQLQLKVQRLHDIETENQK 128
             + E  + S++SK+   A    ++ L +    + AL  +  +Q QL  +   D   +  +
Sbjct: 1911 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE---DAARQRAE 1967

Query: 129  LRETLEEYNKEFAEVKNQEVTIK-ALKEKIREYEQTLKNQAETIALEK---EQKLQNDFA 184
                L E      E    +   + ALKEK  E E+ L+  AE  A ++   E++     A
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKA 2026

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            + E +L + + ++ S+LE  +  V+       +   E+  LK  +++    KA E+E+  
Sbjct: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELEL-- 2083

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAK 304
             +L R    AE   R  E  + +L +A    QLA++ ++    A E + +S    E AA+
Sbjct: 2084 -ELGRIRSNAEDTLRSKE--QAELEAARQR-QLAAEEERRRREAEERVQKSLAAEEEAAR 2139

Query: 305  EREIAQLVEDVQRLQASLT---KLRENSASQIS---QLEQQLSAKNSTLKQLEEKLKGQA 358
            +R+ A  +E+V+RL+A +    +LRE +  + +   QL Q+ + K    ++       Q 
Sbjct: 2140 QRKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2197

Query: 359  DYEEVKKELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
              +E+++ L   +S ++    E    + AA+  E   ++  R  ++  +  ++  ++   
Sbjct: 2198 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAERLK 2255

Query: 418  RCAELQVRITEAVATATE------QRELIARLEQDLSIIQSIQRPDAE-----GAAEHRL 466
            + AE Q +       A E      ++E   R + + + ++  Q  DAE       AE  L
Sbjct: 2256 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315

Query: 467  EKIPEPIKEATALFYG------------------PAAPASGALPEGQVDSLLSIISSQRE 508
             +  +  +E T L                      A     A    QV+  L  +  Q E
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2375

Query: 509  RFRARNQELEAENRL-----AQHTLQALQSELDSLR 539
                    +EAENR        +T + LQ E + ++
Sbjct: 2376 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2411



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 75/388 (19%), Positives = 163/388 (42%), Gaps = 56/388 (14%)

Query: 16   DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
            +L Q Q+EL   A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2467 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2523

Query: 70   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2524 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2580

Query: 127  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2581 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2639

Query: 175  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2640 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2699

Query: 212  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2700 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2759

Query: 272  NHSLQLASQIQKAPDVAIE-VLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLREN 328
              +L         P    E   +   L  +++A+  + A ++  E++QRL    T + E 
Sbjct: 2760 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2819

Query: 329  SASQISQ--LEQQLSAKNSTLKQLEEKL 354
            +  +  +  L+ + S     LK   EKL
Sbjct: 2820 ARREDVRHYLQGRSSIAGLLLKATNEKL 2847



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 87/462 (18%), Positives = 181/462 (39%), Gaps = 61/462 (13%)

Query: 125  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 1162 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1211

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1212 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1266

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIE--------VLTR-S 295
              L++   +AE  Q   + LR++L  A    +   Q     DV +E        +L R  
Sbjct: 1267 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1326

Query: 296  SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 338
            ++  +   ++RE+ QL                 ++D +R Q  +  +     +    + +
Sbjct: 1327 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1383

Query: 339  QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 396
            QL  + + L+++E   +   + +   K+ +N +K  E    +  A  +  A P       
Sbjct: 1384 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1437

Query: 397  KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 456
            K   +QS + ++     DL    +EL    ++ +   +   E + R+E++  + +  +  
Sbjct: 1438 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1494

Query: 457  DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 511
            + E  AE      +  ++ E   +A A     A      + E  V    + + +Q+++ R
Sbjct: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1553

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 553
            +  +EL+   + ++  +QA   + ++     +++ E+I+ ++
Sbjct: 1554 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 125/538 (23%), Positives = 233/538 (43%), Gaps = 54/538 (10%)

Query: 13   KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
            K+F  Q L++  +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L
Sbjct: 2149 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2208

Query: 69   KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
             S + +++ LSK     EA    +  R  D        +  + LQ + +++  +  E  +
Sbjct: 2209 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2260

Query: 129  LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
            L    +E  +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L    
Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2318

Query: 184  AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
             E+ R+LQE +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ 
Sbjct: 2319 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2366

Query: 244  MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSS------L 297
            + ++ RA  RAE   +      E++    H  +LA+Q +      +E+  + S      L
Sbjct: 2367 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2426

Query: 298  EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ 357
               +A  ERE  +L ++ + LQ    +++     Q+ Q  Q L  + S L + +  L+ +
Sbjct: 2427 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQRE 2484

Query: 358  ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
               E+ K +L  L   E A ++    ++  +  + +  E+ R + S   A R  +    G
Sbjct: 2485 RFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2543

Query: 418  RCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPI 473
                 Q  + +      +Q EL+A    RL + L +++   R     A  H  E     +
Sbjct: 2544 -VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTASQV 2598

Query: 474  KEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 527
                 L  G  A   PA+ A PE   D L   +S+QR +  A     E   RLAQ HT
Sbjct: 2599 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2655



 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 137/589 (23%), Positives = 230/589 (39%), Gaps = 103/589 (17%)

Query: 16   DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
            +LQQL++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+
Sbjct: 1399 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1453

Query: 76   DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
             AL  R++EAEA      +          A  L +Q+Q + QR    E E          
Sbjct: 1454 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1504

Query: 126  ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
                 Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K + 
Sbjct: 1505 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1561

Query: 182  DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
             FAEK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1616

Query: 238  DEIEMIMTDLERANQRAEVAQREAETLREQLSSANH----------------SLQLASQI 281
            +E   +    E   Q+  +AQ EAE  +E+                        +L  Q 
Sbjct: 1617 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1676

Query: 282  QKAPDVAIEVLT------------------RSSLEVELAAKEREIAQLVEDVQRLQASLT 323
            Q A   A + L                   R  LE ELA  +RE A   +  Q L+A L 
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736

Query: 324  KLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPSEG 380
            K+R      ++   +      ST ++ +++L+ +A  + E+ +E   L+++  E      
Sbjct: 1737 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1796

Query: 381  AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELI 440
               +DAA+       E  R L  + AA+        G    L+     A+     + E +
Sbjct: 1797 LAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENERL 1844

Query: 441  ARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE-----GQ 495
             RL +D    ++ QR   E  A      I E + +             G + +      Q
Sbjct: 1845 RRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1900

Query: 496  VDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 539
            V+  +  + +  E+  A   ELE E       A+ TL++  Q+EL++ R
Sbjct: 1901 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1949



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 125/610 (20%), Positives = 230/610 (37%), Gaps = 80/610 (13%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
            R   +  Q   DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q 
Sbjct: 1114 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1168

Query: 74   EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
             +     R +E E     L  Y+   D         LG  LQ   +R   I+     ++Q
Sbjct: 1169 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1220

Query: 128  KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
             +RE L +      E++          EK+ E ++  K     I              K+
Sbjct: 1221 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1259

Query: 188  RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
             +LQ        +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L
Sbjct: 1260 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1319

Query: 248  ERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEV------EL 301
             R  +   +A+++    RE+L+    +L+   Q+ +A   A     R + E+      E+
Sbjct: 1320 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1379

Query: 302  AAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYE 361
              +E       +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++      
Sbjct: 1380 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR------ 1433

Query: 362  EVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLSGR 418
                   +   +E    +  G +   + L     E   + R  Q E   LR    D S R
Sbjct: 1434 ------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487

Query: 419  CAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAAEH 464
              + +V +      EA A   +QR L A  E  L   ++ +R            + A E 
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1547

Query: 465  RLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLA 524
                    ++   A F    A    +L E  V   ++ +  + ER   +  E E     A
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERAREEA 1605

Query: 525  QHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFS 581
            +  L+  Q   +E   LR    ++ ++    Q+   +     + E R   + EE+     
Sbjct: 1606 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1665

Query: 582  SFSKRERQRK 591
              +++E +++
Sbjct: 1666 ELAEQELEKQ 1675



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 122/646 (18%), Positives = 257/646 (39%), Gaps = 98/646 (15%)

Query: 18   QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
            Q+  R+L         R    E++    ++Q  +  + T +    Q   +L   +GE +A
Sbjct: 2008 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ----QEQSVLDQLRGEAEA 2063

Query: 78   LSKRSKEAEAAFLNVYKRLIDVPDPVPALD-LGQQLQLKVQRLHDIETENQKLRETLEEY 136
              + ++EAE A +   +        V   + L Q  + + Q     +   +KLR+  E+ 
Sbjct: 2064 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2123

Query: 137  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
                A+ +       AL++K          QA    +EK +K       ++ ++++   +
Sbjct: 2124 AARRAQAEQA-----ALRQK----------QAADAEMEKHKKFAEQTLRQKAQVEQELTT 2168

Query: 197  TTSKLEEAEHKVQSLQTALEKTRT--------------ELFDLKTKYDEETTAK----AD 238
               +LEE +H+   L   L++ +               ELF ++ + +E +  K    A+
Sbjct: 2169 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2228

Query: 239  EIEMIMTDLERANQ-----------------RAEVAQREAETLREQLSSANHSLQ--LAS 279
               +I+ D +   +                 R  VA +EA  LR QL+  + + Q  LA 
Sbjct: 2229 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE 2287

Query: 280  QIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQ 339
            ++ K    A++  TR   E EL  +++E+AQ  E  +RLQ    ++ +  A +    ++ 
Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRT 2345

Query: 340  LSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNR 399
            L A+       + +L+  A+ E +K     L+  E + ++    +DA +  +        
Sbjct: 2346 LEAER------QRQLEMSAEAERLK-----LRVAEMSRAQARAEEDAQRFRK-------- 2386

Query: 400  SLQSENAALRISNSDLSGR-----CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQ 454
              Q+E    ++  ++L+ +        L+++  ++   A   RE IA LE++   +Q   
Sbjct: 2387 --QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2444

Query: 455  RPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLS---IISSQRERFR 511
            +     + E +  +  + ++E  AL     +         + DSLL     I  ++ +  
Sbjct: 2445 KLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLLQRERFIEQEKAKLE 2495

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSS 571
               Q+  A+ +  +   Q  Q +++  R   +   E+ +  Q     G      EL+   
Sbjct: 2496 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555

Query: 572  QYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMART 617
            Q   + +   +   +  + +   L    +A L+    V ++++A T
Sbjct: 2556 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2601



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 127/576 (22%), Positives = 241/576 (41%), Gaps = 70/576 (12%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKS--- 70
            R + +Q +++       LA  Q E+  + ++  E   E  K     +R ++  LL S   
Sbjct: 1697 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-----VRAEMEVLLASKAR 1751

Query: 71   FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPAL--DLGQQLQLKVQRLHDIETENQK 128
             + E  + S++SK+   A    ++ L +    + AL  +  +Q QL  +   D   +  +
Sbjct: 1752 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE---DAARQRAE 1808

Query: 129  LRETLEEYNKEFAEVKNQEVTIK-ALKEKIREYEQTLKNQAETIALEK---EQKLQNDFA 184
                L E      E    +   + ALKEK  E E+ L+  AE  A ++   E++     A
Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKA 1867

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            + E +L + + ++ S+LE  +  V+       +   E+  LK  +++    KA E+E+  
Sbjct: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELEL-- 1924

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAK 304
             +L R    AE   R  E  + +L +A    QLA++ ++    A E + +S    E AA+
Sbjct: 1925 -ELGRIRSNAEDTLRSKE--QAELEAARQR-QLAAEEERRRREAEERVQKSLAAEEEAAR 1980

Query: 305  EREIAQLVEDVQRLQASLT---KLRENSASQIS---QLEQQLSAKNSTLKQLEEKLKGQA 358
            +R+ A  +E+V+RL+A +    +LRE +  + +   QL Q+ + K    ++       Q 
Sbjct: 1981 QRKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2038

Query: 359  DYEEVKKELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
              +E+++ L   +S ++    E    + AA+  E   ++  R  ++  +  ++  ++   
Sbjct: 2039 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAERLK 2096

Query: 418  RCAELQVRITEAVATATE------QRELIARLEQDLSIIQSIQRPDAE-----GAAEHRL 466
            + AE Q +       A E      ++E   R + + + ++  Q  DAE       AE  L
Sbjct: 2097 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156

Query: 467  EKIPEPIKEATALFYG------------------PAAPASGALPEGQVDSLLSIISSQRE 508
             +  +  +E T L                      A     A    QV+  L  +  Q E
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2216

Query: 509  RFRARNQELEAENRL-----AQHTLQALQSELDSLR 539
                    +EAENR        +T + LQ E + ++
Sbjct: 2217 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2252



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 75/388 (19%), Positives = 163/388 (42%), Gaps = 56/388 (14%)

Query: 16   DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
            +L Q Q+EL   A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2308 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2364

Query: 70   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2365 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2421

Query: 127  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2422 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2480

Query: 175  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2481 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2540

Query: 212  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2541 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2600

Query: 272  NHSLQLASQIQKAPDVAIE-VLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLREN 328
              +L         P    E   +   L  +++A+  + A ++  E++QRL    T + E 
Sbjct: 2601 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2660

Query: 329  SASQISQ--LEQQLSAKNSTLKQLEEKL 354
            +  +  +  L+ + S     LK   EKL
Sbjct: 2661 ARREDVRHYLQGRSSIAGLLLKATNEKL 2688



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 87/462 (18%), Positives = 181/462 (39%), Gaps = 61/462 (13%)

Query: 125  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 1003 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1052

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1053 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1107

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIE--------VLTR-S 295
              L++   +AE  Q   + LR++L  A    +   Q     DV +E        +L R  
Sbjct: 1108 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1167

Query: 296  SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 338
            ++  +   ++RE+ QL                 ++D +R Q  +  +     +    + +
Sbjct: 1168 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1224

Query: 339  QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 396
            QL  + + L+++E   +   + +   K+ +N +K  E    +  A  +  A P       
Sbjct: 1225 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1278

Query: 397  KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 456
            K   +QS + ++     DL    +EL    ++ +   +   E + R+E++  + +  +  
Sbjct: 1279 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1335

Query: 457  DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 511
            + E  AE      +  ++ E   +A A     A      + E  V    + + +Q+++ R
Sbjct: 1336 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1394

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 553
            +  +EL+   + ++  +QA   + ++     +++ E+I+ ++
Sbjct: 1395 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 125/538 (23%), Positives = 233/538 (43%), Gaps = 54/538 (10%)

Query: 13   KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
            K+F  Q L++  +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L
Sbjct: 2157 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2216

Query: 69   KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
             S + +++ LSK     EA    +  R  D        +  + LQ + +++  +  E  +
Sbjct: 2217 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2268

Query: 129  LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
            L    +E  +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L    
Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2326

Query: 184  AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
             E+ R+LQE +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ 
Sbjct: 2327 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2374

Query: 244  MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSS------L 297
            + ++ RA  RAE   +      E++    H  +LA+Q +      +E+  + S      L
Sbjct: 2375 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2434

Query: 298  EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ 357
               +A  ERE  +L ++ + LQ    +++     Q+ Q  Q L  + S L + +  L+ +
Sbjct: 2435 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQRE 2492

Query: 358  ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
               E+ K +L  L   E A ++    ++  +  + +  E+ R + S   A R  +    G
Sbjct: 2493 RFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2551

Query: 418  RCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPI 473
                 Q  + +      +Q EL+A    RL + L +++   R     A  H  E     +
Sbjct: 2552 -VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTASQV 2606

Query: 474  KEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 527
                 L  G  A   PA+ A PE   D L   +S+QR +  A     E   RLAQ HT
Sbjct: 2607 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2663



 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 137/589 (23%), Positives = 230/589 (39%), Gaps = 103/589 (17%)

Query: 16   DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
            +LQQL++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1461

Query: 76   DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
             AL  R++EAEA      +          A  L +Q+Q + QR    E E          
Sbjct: 1462 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1512

Query: 126  ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
                 Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K + 
Sbjct: 1513 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1569

Query: 182  DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
             FAEK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA
Sbjct: 1570 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1624

Query: 238  DEIEMIMTDLERANQRAEVAQREAETLREQLSSANH----------------SLQLASQI 281
            +E   +    E   Q+  +AQ EAE  +E+                        +L  Q 
Sbjct: 1625 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1684

Query: 282  QKAPDVAIEVLT------------------RSSLEVELAAKEREIAQLVEDVQRLQASLT 323
            Q A   A + L                   R  LE ELA  +RE A   +  Q L+A L 
Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744

Query: 324  KLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPSEG 380
            K+R      ++   +      ST ++ +++L+ +A  + E+ +E   L+++  E      
Sbjct: 1745 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1804

Query: 381  AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELI 440
               +DAA+       E  R L  + AA+        G    L+     A+     + E +
Sbjct: 1805 LAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENERL 1852

Query: 441  ARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE-----GQ 495
             RL +D    ++ QR   E  A      I E + +             G + +      Q
Sbjct: 1853 RRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1908

Query: 496  VDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 539
            V+  +  + +  E+  A   ELE E       A+ TL++  Q+EL++ R
Sbjct: 1909 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1957



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 125/610 (20%), Positives = 230/610 (37%), Gaps = 80/610 (13%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
            R   +  Q   DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q 
Sbjct: 1122 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1176

Query: 74   EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
             +     R +E E     L  Y+   D         LG  LQ   +R   I+     ++Q
Sbjct: 1177 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1228

Query: 128  KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
             +RE L +      E++          EK+ E ++  K     I              K+
Sbjct: 1229 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1267

Query: 188  RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
             +LQ        +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L
Sbjct: 1268 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1327

Query: 248  ERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEV------EL 301
             R  +   +A+++    RE+L+    +L+   Q+ +A   A     R + E+      E+
Sbjct: 1328 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1387

Query: 302  AAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYE 361
              +E       +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++      
Sbjct: 1388 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR------ 1441

Query: 362  EVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLSGR 418
                   +   +E    +  G +   + L     E   + R  Q E   LR    D S R
Sbjct: 1442 ------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495

Query: 419  CAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAAEH 464
              + +V +      EA A   +QR L A  E  L   ++ +R            + A E 
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1555

Query: 465  RLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLA 524
                    ++   A F    A    +L E  V   ++ +  + ER   +  E E     A
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERAREEA 1613

Query: 525  QHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFS 581
            +  L+  Q   +E   LR    ++ ++    Q+   +     + E R   + EE+     
Sbjct: 1614 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1673

Query: 582  SFSKRERQRK 591
              +++E +++
Sbjct: 1674 ELAEQELEKQ 1683



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 122/646 (18%), Positives = 257/646 (39%), Gaps = 98/646 (15%)

Query: 18   QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
            Q+  R+L         R    E++    ++Q  +  + T +    Q   +L   +GE +A
Sbjct: 2016 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ----QEQSVLDQLRGEAEA 2071

Query: 78   LSKRSKEAEAAFLNVYKRLIDVPDPVPALD-LGQQLQLKVQRLHDIETENQKLRETLEEY 136
              + ++EAE A +   +        V   + L Q  + + Q     +   +KLR+  E+ 
Sbjct: 2072 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2131

Query: 137  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
                A+ +       AL++K          QA    +EK +K       ++ ++++   +
Sbjct: 2132 AARRAQAEQA-----ALRQK----------QAADAEMEKHKKFAEQTLRQKAQVEQELTT 2176

Query: 197  TTSKLEEAEHKVQSLQTALEKTRT--------------ELFDLKTKYDEETTAK----AD 238
               +LEE +H+   L   L++ +               ELF ++ + +E +  K    A+
Sbjct: 2177 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2236

Query: 239  EIEMIMTDLERANQ-----------------RAEVAQREAETLREQLSSANHSLQ--LAS 279
               +I+ D +   +                 R  VA +EA  LR QL+  + + Q  LA 
Sbjct: 2237 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE 2295

Query: 280  QIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQ 339
            ++ K    A++  TR   E EL  +++E+AQ  E  +RLQ    ++ +  A +    ++ 
Sbjct: 2296 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRT 2353

Query: 340  LSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNR 399
            L A+       + +L+  A+ E +K     L+  E + ++    +DA +  +        
Sbjct: 2354 LEAER------QRQLEMSAEAERLK-----LRVAEMSRAQARAEEDAQRFRK-------- 2394

Query: 400  SLQSENAALRISNSDLSGR-----CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQ 454
              Q+E    ++  ++L+ +        L+++  ++   A   RE IA LE++   +Q   
Sbjct: 2395 --QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2452

Query: 455  RPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLS---IISSQRERFR 511
            +     + E +  +  + ++E  AL     +         + DSLL     I  ++ +  
Sbjct: 2453 KLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLLQRERFIEQEKAKLE 2503

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSS 571
               Q+  A+ +  +   Q  Q +++  R   +   E+ +  Q     G      EL+   
Sbjct: 2504 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2563

Query: 572  QYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMART 617
            Q   + +   +   +  + +   L    +A L+    V ++++A T
Sbjct: 2564 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2609



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 127/576 (22%), Positives = 241/576 (41%), Gaps = 70/576 (12%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKS--- 70
            R + +Q +++       LA  Q E+  + ++  E   E  K     +R ++  LL S   
Sbjct: 1705 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-----VRAEMEVLLASKAR 1759

Query: 71   FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPAL--DLGQQLQLKVQRLHDIETENQK 128
             + E  + S++SK+   A    ++ L +    + AL  +  +Q QL  +   D   +  +
Sbjct: 1760 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE---DAARQRAE 1816

Query: 129  LRETLEEYNKEFAEVKNQEVTIK-ALKEKIREYEQTLKNQAETIALEK---EQKLQNDFA 184
                L E      E    +   + ALKEK  E E+ L+  AE  A ++   E++     A
Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKA 1875

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            + E +L + + ++ S+LE  +  V+       +   E+  LK  +++    KA E+E+  
Sbjct: 1876 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELEL-- 1932

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAK 304
             +L R    AE   R  E  + +L +A    QLA++ ++    A E + +S    E AA+
Sbjct: 1933 -ELGRIRSNAEDTLRSKE--QAELEAARQR-QLAAEEERRRREAEERVQKSLAAEEEAAR 1988

Query: 305  EREIAQLVEDVQRLQASLT---KLRENSASQIS---QLEQQLSAKNSTLKQLEEKLKGQA 358
            +R+ A  +E+V+RL+A +    +LRE +  + +   QL Q+ + K    ++       Q 
Sbjct: 1989 QRKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2046

Query: 359  DYEEVKKELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
              +E+++ L   +S ++    E    + AA+  E   ++  R  ++  +  ++  ++   
Sbjct: 2047 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAERLK 2104

Query: 418  RCAELQVRITEAVATATE------QRELIARLEQDLSIIQSIQRPDAE-----GAAEHRL 466
            + AE Q +       A E      ++E   R + + + ++  Q  DAE       AE  L
Sbjct: 2105 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164

Query: 467  EKIPEPIKEATALFYG------------------PAAPASGALPEGQVDSLLSIISSQRE 508
             +  +  +E T L                      A     A    QV+  L  +  Q E
Sbjct: 2165 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2224

Query: 509  RFRARNQELEAENRL-----AQHTLQALQSELDSLR 539
                    +EAENR        +T + LQ E + ++
Sbjct: 2225 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2260



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 75/388 (19%), Positives = 163/388 (42%), Gaps = 56/388 (14%)

Query: 16   DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
            +L Q Q+EL   A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2316 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2372

Query: 70   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2373 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2429

Query: 127  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2430 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2488

Query: 175  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2489 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2548

Query: 212  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2549 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2608

Query: 272  NHSLQLASQIQKAPDVAIE-VLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLREN 328
              +L         P    E   +   L  +++A+  + A ++  E++QRL    T + E 
Sbjct: 2609 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2668

Query: 329  SASQISQ--LEQQLSAKNSTLKQLEEKL 354
            +  +  +  L+ + S     LK   EKL
Sbjct: 2669 ARREDVRHYLQGRSSIAGLLLKATNEKL 2696



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 87/462 (18%), Positives = 181/462 (39%), Gaps = 61/462 (13%)

Query: 125  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 1011 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1060

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1061 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1115

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIE--------VLTR-S 295
              L++   +AE  Q   + LR++L  A    +   Q     DV +E        +L R  
Sbjct: 1116 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1175

Query: 296  SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 338
            ++  +   ++RE+ QL                 ++D +R Q  +  +     +    + +
Sbjct: 1176 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1232

Query: 339  QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 396
            QL  + + L+++E   +   + +   K+ +N +K  E    +  A  +  A P       
Sbjct: 1233 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1286

Query: 397  KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 456
            K   +QS + ++     DL    +EL    ++ +   +   E + R+E++  + +  +  
Sbjct: 1287 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1343

Query: 457  DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 511
            + E  AE      +  ++ E   +A A     A      + E  V    + + +Q+++ R
Sbjct: 1344 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1402

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 553
            +  +EL+   + ++  +QA   + ++     +++ E+I+ ++
Sbjct: 1403 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 125/538 (23%), Positives = 233/538 (43%), Gaps = 54/538 (10%)

Query: 13   KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
            K+F  Q L++  +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L
Sbjct: 2198 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2257

Query: 69   KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
             S + +++ LSK     EA    +  R  D        +  + LQ + +++  +  E  +
Sbjct: 2258 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2309

Query: 129  LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
            L    +E  +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L    
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2367

Query: 184  AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
             E+ R+LQE +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ 
Sbjct: 2368 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2415

Query: 244  MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSS------L 297
            + ++ RA  RAE   +      E++    H  +LA+Q +      +E+  + S      L
Sbjct: 2416 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2475

Query: 298  EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ 357
               +A  ERE  +L ++ + LQ    +++     Q+ Q  Q L  + S L + +  L+ +
Sbjct: 2476 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQRE 2533

Query: 358  ADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
               E+ K +L  L   E A ++    ++  +  + +  E+ R + S   A R  +    G
Sbjct: 2534 RFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2592

Query: 418  RCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPI 473
                 Q  + +      +Q EL+A    RL + L +++   R     A  H  E     +
Sbjct: 2593 -VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTASQV 2647

Query: 474  KEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 527
                 L  G  A   PA+ A PE   D L   +S+QR +  A     E   RLAQ HT
Sbjct: 2648 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2704



 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 137/589 (23%), Positives = 230/589 (39%), Gaps = 103/589 (17%)

Query: 16   DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
            +LQQL++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+
Sbjct: 1448 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1502

Query: 76   DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
             AL  R++EAEA      +          A  L +Q+Q + QR    E E          
Sbjct: 1503 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1553

Query: 126  ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
                 Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K + 
Sbjct: 1554 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1610

Query: 182  DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
             FAEK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA
Sbjct: 1611 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1665

Query: 238  DEIEMIMTDLERANQRAEVAQREAETLREQLSSANH----------------SLQLASQI 281
            +E   +    E   Q+  +AQ EAE  +E+                        +L  Q 
Sbjct: 1666 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1725

Query: 282  QKAPDVAIEVLT------------------RSSLEVELAAKEREIAQLVEDVQRLQASLT 323
            Q A   A + L                   R  LE ELA  +RE A   +  Q L+A L 
Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785

Query: 324  KLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPSEG 380
            K+R      ++   +      ST ++ +++L+ +A  + E+ +E   L+++  E      
Sbjct: 1786 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1845

Query: 381  AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELI 440
               +DAA+       E  R L  + AA+        G    L+     A+     + E +
Sbjct: 1846 LAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENERL 1893

Query: 441  ARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE-----GQ 495
             RL +D    ++ QR   E  A      I E + +             G + +      Q
Sbjct: 1894 RRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1949

Query: 496  VDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 539
            V+  +  + +  E+  A   ELE E       A+ TL++  Q+EL++ R
Sbjct: 1950 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1998



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 125/610 (20%), Positives = 230/610 (37%), Gaps = 80/610 (13%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
            R   +  Q   DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q 
Sbjct: 1163 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1217

Query: 74   EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
             +     R +E E     L  Y+   D         LG  LQ   +R   I+     ++Q
Sbjct: 1218 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1269

Query: 128  KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
             +RE L +      E++          EK+ E ++  K     I              K+
Sbjct: 1270 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1308

Query: 188  RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
             +LQ        +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L
Sbjct: 1309 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1368

Query: 248  ERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEV------EL 301
             R  +   +A+++    RE+L+    +L+   Q+ +A   A     R + E+      E+
Sbjct: 1369 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1428

Query: 302  AAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYE 361
              +E       +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++      
Sbjct: 1429 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR------ 1482

Query: 362  EVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLSGR 418
                   +   +E    +  G +   + L     E   + R  Q E   LR    D S R
Sbjct: 1483 ------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536

Query: 419  CAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAAEH 464
              + +V +      EA A   +QR L A  E  L   ++ +R            + A E 
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1596

Query: 465  RLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLA 524
                    ++   A F    A    +L E  V   ++ +  + ER   +  E E     A
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERAREEA 1654

Query: 525  QHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFS 581
            +  L+  Q   +E   LR    ++ ++    Q+   +     + E R   + EE+     
Sbjct: 1655 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1714

Query: 582  SFSKRERQRK 591
              +++E +++
Sbjct: 1715 ELAEQELEKQ 1724



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 122/646 (18%), Positives = 257/646 (39%), Gaps = 98/646 (15%)

Query: 18   QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
            Q+  R+L         R    E++    ++Q  +  + T +    Q   +L   +GE +A
Sbjct: 2057 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ----QEQSVLDQLRGEAEA 2112

Query: 78   LSKRSKEAEAAFLNVYKRLIDVPDPVPALD-LGQQLQLKVQRLHDIETENQKLRETLEEY 136
              + ++EAE A +   +        V   + L Q  + + Q     +   +KLR+  E+ 
Sbjct: 2113 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2172

Query: 137  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
                A+ +       AL++K          QA    +EK +K       ++ ++++   +
Sbjct: 2173 AARRAQAEQA-----ALRQK----------QAADAEMEKHKKFAEQTLRQKAQVEQELTT 2217

Query: 197  TTSKLEEAEHKVQSLQTALEKTRT--------------ELFDLKTKYDEETTAK----AD 238
               +LEE +H+   L   L++ +               ELF ++ + +E +  K    A+
Sbjct: 2218 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2277

Query: 239  EIEMIMTDLERANQ-----------------RAEVAQREAETLREQLSSANHSLQ--LAS 279
               +I+ D +   +                 R  VA +EA  LR QL+  + + Q  LA 
Sbjct: 2278 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE 2336

Query: 280  QIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQ 339
            ++ K    A++  TR   E EL  +++E+AQ  E  +RLQ    ++ +  A +    ++ 
Sbjct: 2337 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRT 2394

Query: 340  LSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNR 399
            L A+       + +L+  A+ E +K     L+  E + ++    +DA +  +        
Sbjct: 2395 LEAER------QRQLEMSAEAERLK-----LRVAEMSRAQARAEEDAQRFRK-------- 2435

Query: 400  SLQSENAALRISNSDLSGR-----CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQ 454
              Q+E    ++  ++L+ +        L+++  ++   A   RE IA LE++   +Q   
Sbjct: 2436 --QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2493

Query: 455  RPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLS---IISSQRERFR 511
            +     + E +  +  + ++E  AL     +         + DSLL     I  ++ +  
Sbjct: 2494 KLLQLKSEEMQTVQQEQLLQETQALQQSFLS---------EKDSLLQRERFIEQEKAKLE 2544

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSS 571
               Q+  A+ +  +   Q  Q +++  R   +   E+ +  Q     G      EL+   
Sbjct: 2545 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604

Query: 572  QYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMART 617
            Q   + +   +   +  + +   L    +A L+    V ++++A T
Sbjct: 2605 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2650



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 127/576 (22%), Positives = 241/576 (41%), Gaps = 70/576 (12%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKS--- 70
            R + +Q +++       LA  Q E+  + ++  E   E  K     +R ++  LL S   
Sbjct: 1746 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-----VRAEMEVLLASKAR 1800

Query: 71   FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPAL--DLGQQLQLKVQRLHDIETENQK 128
             + E  + S++SK+   A    ++ L +    + AL  +  +Q QL  +   D   +  +
Sbjct: 1801 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE---DAARQRAE 1857

Query: 129  LRETLEEYNKEFAEVKNQEVTIK-ALKEKIREYEQTLKNQAETIALEK---EQKLQNDFA 184
                L E      E    +   + ALKEK  E E+ L+  AE  A ++   E++     A
Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENER-LRRLAEDEAFQRRRLEEQAAQHKA 1916

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            + E +L + + ++ S+LE  +  V+       +   E+  LK  +++    KA E+E+  
Sbjct: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA-ELEL-- 1973

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAK 304
             +L R    AE   R  E  + +L +A    QLA++ ++    A E + +S    E AA+
Sbjct: 1974 -ELGRIRSNAEDTLRSKE--QAELEAARQR-QLAAEEERRRREAEERVQKSLAAEEEAAR 2029

Query: 305  EREIAQLVEDVQRLQASLT---KLRENSASQIS---QLEQQLSAKNSTLKQLEEKLKGQA 358
            +R+ A  +E+V+RL+A +    +LRE +  + +   QL Q+ + K    ++       Q 
Sbjct: 2030 QRKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2087

Query: 359  DYEEVKKELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417
              +E+++ L   +S ++    E    + AA+  E   ++  R  ++  +  ++  ++   
Sbjct: 2088 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAERLK 2145

Query: 418  RCAELQVRITEAVATATE------QRELIARLEQDLSIIQSIQRPDAE-----GAAEHRL 466
            + AE Q +       A E      ++E   R + + + ++  Q  DAE       AE  L
Sbjct: 2146 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205

Query: 467  EKIPEPIKEATALFYG------------------PAAPASGALPEGQVDSLLSIISSQRE 508
             +  +  +E T L                      A     A    QV+  L  +  Q E
Sbjct: 2206 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2265

Query: 509  RFRARNQELEAENRL-----AQHTLQALQSELDSLR 539
                    +EAENR        +T + LQ E + ++
Sbjct: 2266 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2301



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 75/388 (19%), Positives = 163/388 (42%), Gaps = 56/388 (14%)

Query: 16   DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
            +L Q Q+EL   A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2357 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2413

Query: 70   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2414 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2470

Query: 127  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2471 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2529

Query: 175  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2530 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2589

Query: 212  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2590 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2649

Query: 272  NHSLQLASQIQKAPDVAIE-VLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLREN 328
              +L         P    E   +   L  +++A+  + A ++  E++QRL    T + E 
Sbjct: 2650 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2709

Query: 329  SASQISQ--LEQQLSAKNSTLKQLEEKL 354
            +  +  +  L+ + S     LK   EKL
Sbjct: 2710 ARREDVRHYLQGRSSIAGLLLKATNEKL 2737



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 87/462 (18%), Positives = 181/462 (39%), Gaps = 61/462 (13%)

Query: 125  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 1052 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1101

Query: 185  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1102 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1156

Query: 245  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIE--------VLTR-S 295
              L++   +AE  Q   + LR++L  A    +   Q     DV +E        +L R  
Sbjct: 1157 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1216

Query: 296  SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 338
            ++  +   ++RE+ QL                 ++D +R Q  +  +     +    + +
Sbjct: 1217 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1273

Query: 339  QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 396
            QL  + + L+++E   +   + +   K+ +N +K  E    +  A  +  A P       
Sbjct: 1274 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1327

Query: 397  KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 456
            K   +QS + ++     DL    +EL    ++ +   +   E + R+E++  + +  +  
Sbjct: 1328 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1384

Query: 457  DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 511
            + E  AE      +  ++ E   +A A     A      + E  V    + + +Q+++ R
Sbjct: 1385 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1443

Query: 512  ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 553
            +  +EL+   + ++  +QA   + ++     +++ E+I+ ++
Sbjct: 1444 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1485


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 136/653 (20%), Positives = 266/653 (40%), Gaps = 120/653 (18%)

Query: 18   QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLR----------KQVAPL 67
            +QLQR++        N + E  + R R +EQ+     +T + +           K    L
Sbjct: 2133 EQLQRDIQER-----NEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSL 2187

Query: 68   LKSFQGEIDALSKRSKEA---EAAFLNVYKRLIDVPDPVPALDLGQQLQLK--VQRLHDI 122
                Q E DA+ ++ KE    E       + L +  + V  L +  ++Q K    RL ++
Sbjct: 2188 EVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247

Query: 123  ETENQKLRETLEEYNKEFAE-------------------VKNQEVTIKALKEKIREYEQT 163
            E EN+  ++ +E+      E                   ++ +EV I  L E++ + +Q 
Sbjct: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQ 2307

Query: 164  LKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELF 223
            LK   +   +E++ +L  D   +   L   Q       EE   +++ L   +EK + EL 
Sbjct: 2308 LKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREE---EIEQLNEVIEKLQQELA 2364

Query: 224  DLKTK-------YDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQ 276
            ++  K         EE  +   ++++++ +     Q+ E A  E   ++  L   N  + 
Sbjct: 2365 NIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMN 2424

Query: 277  LASQ--------------IQKAPD----VAIEVLTRSSLEVELAAKEREIAQLVEDVQRL 318
              +Q              IQ  P+    VAI+ L++   E+E+   E  +  L       
Sbjct: 2425 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLEN----- 2479

Query: 319  QASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK-----GQADYEEVKKE 366
            Q       EN    I        QLE  +SAK+  L Q  +++K     GQ + E ++K+
Sbjct: 2480 QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK 2539

Query: 367  L-NILKSMEFAPSEGAGTQDAAKPLE--VLLLEKNRSLQSENAALRISN----------S 413
            + N+ K +E   +    +Q   + ++      + N+++ SE     I N          S
Sbjct: 2540 IVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS 2599

Query: 414  DLSG---RCAELQVRITE---AVATATEQREL----IARLEQDLSIIQSIQRPDAEGAAE 463
            D+S    R +EL+ ++ E   ++    EQ E+    +   E+ L  +Q +   + +   E
Sbjct: 2600 DISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE 2659

Query: 464  HRLEKIP---EPIKEATALFYGPAAPASGALPEGQVDSLLSIIS-SQRERFRARNQELEA 519
               ++ P   E +K  T LF+  +   SG   E +     S+ + ++   ++ + ++L+ 
Sbjct: 2660 KEKKRSPQDVEVLKTTTELFH--SNEESGFFNELEALRAESVATKAELASYKEKAEKLQE 2717

Query: 520  ENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQ 572
            E  + +  + +LQ +L  +R    +  EK+  L+         D+TE++ S +
Sbjct: 2718 ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEK-------EDETEVQESKK 2763



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 121/566 (21%), Positives = 235/566 (41%), Gaps = 89/566 (15%)

Query: 17   LQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEID 76
            + +L++EL   +  L   + E +Q     I++ RE      E ++ +  P+ +    E +
Sbjct: 1945 IDRLEQELLCASNRLQELEAEQQQ-----IQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999

Query: 77   ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 136
             L K   E +     V     D+   V AL++            D+E +  +  E  +E 
Sbjct: 2000 KLMKEKLEVQCQAEKVRD---DLQKQVKALEI------------DVEEQVSRFIELEQEK 2044

Query: 137  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
            N E  +++ Q   ++   EK+R++        +  A+++E   + D  ++E +  E Q+ 
Sbjct: 2045 NTELMDLRQQNQALEKQLEKMRKF-------LDEQAIDREH--ERDVFQQEIQKLEQQLK 2095

Query: 197  TTSKLEE-AEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAE 255
               + +  +EH+ + +    E+    L +   K  E   +K    E +  D++  N+  E
Sbjct: 2096 VVPRFQPISEHQTREV----EQLANHLKEKTDKCSELLLSK----EQLQRDIQERNEEIE 2147

Query: 256  VAQREAETLREQLSSANHSLQLASQIQKAPDV----AIEVLTRSSLEVELAA-------K 304
              +     L + L      L  A   QK  D     A+E     SLEV+L A       K
Sbjct: 2148 KLEFRVRELEQAL------LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK 2201

Query: 305  EREIAQLVEDVQRLQASLTKLRENSASQISQLEQQL--SAKNSTLKQLEEKLKGQADYEE 362
            E+EI  L E +++ +  L    EN   ++ QL  QL    K ST +  E + + +   ++
Sbjct: 2202 EKEITNLEEQLEQFREEL----ENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDD 2257

Query: 363  VKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAEL 422
            ++K       +    S+   TQD      VL  +  + +Q +   +   N  ++    + 
Sbjct: 2258 MEK-----LGLAIKESDAMSTQDQ----HVLFGKFAQIIQEKEVEIDQLNEQVTK--LQQ 2306

Query: 423  QVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAE--HRLEKIPEPIKEATALF 480
            Q++IT       E+ ELI  LE  +  + S Q        E   +L ++ E +++  A  
Sbjct: 2307 QLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2366

Query: 481  YGPAAPASGALPEGQVDSL---LSIISSQR----ERFRARNQELEAENRLAQHT---LQA 530
                +  + +L E + DSL   L ++ +++    ++    N+E+     + + T   +  
Sbjct: 2367 GQKTSMNAHSLSE-EADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQ 2425

Query: 531  LQSELDSLRADNIKLFEKIKFLQSYP 556
            L  EL SL+ +     E ++ +QS P
Sbjct: 2426 LTQELFSLKRER----ESVEKIQSIP 2447



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 101/510 (19%), Positives = 212/510 (41%), Gaps = 89/510 (17%)

Query: 24  LDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPL---LKSFQGEIDALSK 80
           L A   +L ++Q   EQ    L+E  ++ K    ED   Q++ L   +K ++ E D   +
Sbjct: 264 LQAKQQILTHQQQLEEQDH--LLEDYQKKK----EDFTMQISFLQEKIKVYEMEQDKKVE 317

Query: 81  RSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEF 140
            S + E   +   + +I+  +     +  + L+LK +    + T ++ L E  E+  ++ 
Sbjct: 318 NSNKEE---IQEKETIIEELNTKIIEEEKKTLELKDK----LTTADKLLGELQEQIVQKN 370

Query: 141 AEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSK 200
            E+KN ++ +   K+K R+  + +K    T+  E +++   D   +   +Q  +  T  K
Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVE-ELQKRNHKDSQFETDIVQRMEQETQRK 429

Query: 201 LEE---------AEHKVQSLQTALEKTRTELFDLKTKYDEE----------TTAKADEIE 241
           LE+          +  VQ  Q  + +   ++ ++KT++  E           T   D+I+
Sbjct: 430 LEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK 489

Query: 242 MIMTDLERANQRAE---------------------VAQREAETLREQLSSANHSLQLASQ 280
           ++   +   N + +                       QR+ E L E+LS +   +Q A Q
Sbjct: 490 LMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549

Query: 281 ---------------IQKAPDVAIEVLTRSSLEVELAAK-EREIAQLVEDVQRLQ----A 320
                          +    D+  E+++ S    EL  K E E+      ++ L+    A
Sbjct: 550 TIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA 609

Query: 321 SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEG 380
            L ++ E+  +++ +L  QL      L   EE+L    +  E++  +NI K  +   + G
Sbjct: 610 VLDRMAESQEAELERLRTQL------LFSHEEELSKLKEDLEIEHRINIEKLKD---NLG 660

Query: 381 AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQREL- 439
              +     L+  + +K  ++Q E   L    + L    ++L+      V + +E+  L 
Sbjct: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720

Query: 440 IARLEQDLSIIQSIQRPDAEGAAEHRLEKI 469
           I  L++++ I++  Q    +G  E  ++++
Sbjct: 721 INELQKEIEILR--QEEKEKGTLEQEVQEL 748



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 126/613 (20%), Positives = 248/613 (40%), Gaps = 94/613 (15%)

Query: 14   RFDLQQLQRELDATATVLANRQD-ESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ 72
            +  L+ L++E +A    +A  Q+ E E+ R +L+    E      EDL  +    ++  +
Sbjct: 597  KIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK 656

Query: 73   GEIDALSKRSKEAEAAFLNVYKRLIDVP--DPVPALDLGQQLQLKVQRLHDIE-----TE 125
               D L    K+      N   + I+    +    +    QL L++ +L D++     ++
Sbjct: 657  ---DNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713

Query: 126  NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAE 185
            ++++   + E  KE   ++ +E     L+++++E       Q +T  LEK+ K      E
Sbjct: 714  SEEMTLQINELQKEIEILRQEEKEKGTLEQEVQEL------QLKTELLEKQMK------E 761

Query: 186  KERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMT 245
            KE  LQE          EAE+ +   +   +KT  ++  + T   +E         +I  
Sbjct: 762  KENDLQEKFAQL-----EAENSILKDE---KKTLEDMLKIHTPVSQEE-------RLIFL 806

Query: 246  DLERANQRAEVAQREAETLREQLSSANHS-LQLASQIQKAPDVAIEVLTRSSLEVELAAK 304
            D  ++  +  V ++E E L E+        +QL  +I+K  +               +  
Sbjct: 807  DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNT-------------FSFA 853

Query: 305  EREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ-ADYEEV 363
            E+      +++Q   A L K++++   + S+ +Q+L  K S LK L E+L  Q  +   V
Sbjct: 854  EKNFEVNYQELQEEYACLLKVKDD--LEDSKNKQELEYK-SKLKALNEELHLQRINPTTV 910

Query: 364  KKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQ 423
            K + ++    +   +E     +  +     L+EK    + E   L    SDLS +  +  
Sbjct: 911  KMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKH 970

Query: 424  VRIT---EAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALF 480
              I+   E V +  +++E ++   ++L II +           +R E +     + ++L 
Sbjct: 971  GEISFLNEEVKSLKQEKEQVSLRCRELEIIIN----------HNRAENVQSCDTQVSSLL 1020

Query: 481  YGPAAPASGALPEGQVDSLLSIISSQ-----RERFRARNQELEAENRLAQHTLQALQS-- 533
             G     S    EG V  +      +      ++    N  +  E++  Q  L  L S  
Sbjct: 1021 DGVVTMTSRG-AEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVT 1079

Query: 534  ELDSLRA----DNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQ-------YEERLDPFSS 582
            +  SLRA    +N KL +++  L+      S  +D  L+  +Q       Y   +D    
Sbjct: 1080 KESSLRATQPSENDKLQKELNVLK------SEQNDLRLQMEAQRICLSLVYSTHVDQVRE 1133

Query: 583  FSKRERQRKYLSL 595
            + + E+ +   SL
Sbjct: 1134 YMENEKDKALCSL 1146



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 105/481 (21%), Positives = 193/481 (40%), Gaps = 80/481 (16%)

Query: 125  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF- 183
            E+  +++  E + +E     N   TI +LK+ I + +  L+ +AE     +  +  +D+ 
Sbjct: 2969 EDHSIQQVSEPWLEERKAYIN---TISSLKDLITKMQ--LQREAEVYDSSQSHESFSDWR 3023

Query: 184  AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
             E    LQ+  +   S L  A    ++  TAL  T  +   L    ++    +  E +  
Sbjct: 3024 GELLLALQQVFLEERSVLLAA---FRTELTALGTT--DAVGLLNCLEQRIQEQGVEYQAA 3078

Query: 244  MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSS------L 297
            M  L++A++R+ ++  E + L  Q++    +L+   + +K     +E   +        +
Sbjct: 3079 MECLQKADRRSLLS--EIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEM 3136

Query: 298  EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE------ 351
            +VEL++ +    +L E +   +  + +L+   A    +LE  L A++  LK+LE      
Sbjct: 3137 QVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEV 3196

Query: 352  ------------------------------EKLKGQADYEEVKKELNILK-SMEFAPSEG 380
                                          EK K     E  K+EL  LK S+E      
Sbjct: 3197 KDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRN 3256

Query: 381  AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQV-------RITEAVATA 433
                   +  + LL E  + ++S+        S+  GR  ELQV       RI E  +T 
Sbjct: 3257 LQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3316

Query: 434  TEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE 493
              +REL A+L+      QS  RP     +E  L+++ + ++E     +           +
Sbjct: 3317 DRERELHAQLQSSDGTGQS--RPPL--PSEDLLKELQKQLEEK----HSRIVELLNETEK 3368

Query: 494  GQVDSLLSIISSQRERFRAR-----NQELEAENRLAQHTLQA----LQSELDSLRADNIK 544
             ++DSL +    +++R   R      QE   E +   H LQ+    LQ +L+  R    K
Sbjct: 3369 YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYK 3428

Query: 545  L 545
            L
Sbjct: 3429 L 3429



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 75/395 (18%), Positives = 159/395 (40%), Gaps = 52/395 (13%)

Query: 219 RTELFDLKTKYDEETTAKAD-EIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQL 277
           R E F +   Y E+    +   +EM+ ++L       E   RE E +R  ++     LQ 
Sbjct: 135 REEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMR--VTYGTEGLQQ 192

Query: 278 ASQIQKAPDVAIEVLTRSSLEVELAAKE-----REIAQLVEDVQRLQASLTKLREN---- 328
             + + A      ++T+ +  ++ A +E     RE  +L E  Q+LQ    +L+ +    
Sbjct: 193 LQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLR 252

Query: 329 SASQISQLEQQLSAKNSTL---KQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQD 385
           +++  S     L AK   L   +QLEE+     DY++ K++  +  S             
Sbjct: 253 NSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF------------ 300

Query: 386 AAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQ 445
             + ++V  +E+++ +++ N   +    +      EL  +I E      E ++ +   ++
Sbjct: 301 LQEKIKVYEMEQDKKVENSN---KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADK 357

Query: 446 DLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISS 505
            L  +Q       +     +LE      KE  +                ++  L+  +  
Sbjct: 358 LLGELQEQIVQKNQEIKNMKLELTNSKQKERQS--------------SEEIKQLMGTVEE 403

Query: 506 QRERFRARNQ-ELEAENRLAQHT---LQALQSELDSLRADNIKLFEKIKFLQSYPGRGSG 561
            ++R    +Q E +   R+ Q T   L+ L++ELD +    I   ++    Q      + 
Sbjct: 404 LQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHM----AQ 459

Query: 562 SDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLS 596
            ++ + R+  + E  L  +S+ +  E Q K ++++
Sbjct: 460 MEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVA 494



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 47/227 (20%), Positives = 97/227 (42%), Gaps = 14/227 (6%)

Query: 30   VLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAF 89
            +L   Q + E+   R++E   E +K   + L+ +     +  + +     K  +  + A 
Sbjct: 3344 LLKELQKQLEEKHSRIVELLNETEKYKLDSLQTR-----QQMEKDRQVHRKTLQTEQEAN 3398

Query: 90   LNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVT 149
                K++ ++   V   DL +QL+ K Q+++ ++ E Q+L+  ++E+ K+  E + +  +
Sbjct: 3399 TEGQKKMHELQSKVE--DLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRES 3456

Query: 150  IKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE-RKLQETQMSTTSKLEEAEHKV 208
             + L + + E          T     +QK++ +  E    KL E     T    E E   
Sbjct: 3457 RRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIR 3516

Query: 209  QSLQTALEKTR------TELFDLKTKYDEETTAKADEIEMIMTDLER 249
            Q LQ    K +      +E    +T  DE+     + I+ I+  L++
Sbjct: 3517 QKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQK 3563



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 85/408 (20%), Positives = 160/408 (39%), Gaps = 64/408 (15%)

Query: 40   QSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNV---YKRL 96
            +S+  + E+  E      EDL++Q   L +  + + +  S   K  E  +  +   Y  L
Sbjct: 812  KSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACL 871

Query: 97   IDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEK 156
            + V D +      Q+L+ K +               L+  N+E    +    T+K +K  
Sbjct: 872  LKVKDDLEDSKNKQELEYKSK---------------LKALNEELHLQRINPTTVK-MKSS 915

Query: 157  IREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ---MSTTSKLEEAEHKVQSLQT 213
            + + ++T    AET  LE  + ++ D  E   KL+ T+   +  + +L +   +++    
Sbjct: 916  VFDEDKTFV--AET--LEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG 971

Query: 214  ALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA----------EVAQREAET 263
             +     E+  LK +  E+ + +  E+E+I+      N ++           V    +  
Sbjct: 972  EISFLNEEVKSLKQE-KEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRG 1030

Query: 264  LREQLSSANHSLQLASQIQKAPDVAIEVLT--RSSLEVEL-------AAKEREI-AQLVE 313
                +S  N S    S+I     V+ E +T    S + +L         KE  + A    
Sbjct: 1031 AEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPS 1090

Query: 314  DVQRLQASLTKLRENSASQISQLEQQ---LSAKNST-LKQLEEKLKGQAD---------- 359
            +  +LQ  L  L+        Q+E Q   LS   ST + Q+ E ++ + D          
Sbjct: 1091 ENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEEL 1150

Query: 360  ---YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSE 404
                EE  KEL  +  +E    +   T D  KPL +L+ +  +++  E
Sbjct: 1151 IFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEE 1198



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 122/611 (19%), Positives = 230/611 (37%), Gaps = 113/611 (18%)

Query: 11   YWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREF--KKNTPEDLRKQVAPLL 68
            Y+    L Q Q       TV    ++E +   K L E  +E     + P D+ +    +L
Sbjct: 1487 YFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVL 1546

Query: 69   KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE--- 125
                     +S+     +  F  + ++ I     V ++D  +QL L  ++L D+  E   
Sbjct: 1547 --------TISEEMFSKDKTF--IVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVR 1596

Query: 126  ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQA----ETIALEKEQ 177
                +Q+  E L + +    +++ Q    + L+E+I+   + L  ++    E +  E+E+
Sbjct: 1597 QYQEHQQATELLRQAHMR--QMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERER 1654

Query: 178  KL--------QNDFAEKERKLQETQMSTTS---------KLEEAEHKVQSLQT------- 213
             L        Q   A +E+   E + S+T          ++EE   K + L         
Sbjct: 1655 VLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPP 1714

Query: 214  --------ALEKTRTELFDLKTKYDEETTAKADEI-EMIMTDLERANQRAEVA----QRE 260
                    AL+K    L  +  +  + T A  + I   ++  L+R+++    A    + E
Sbjct: 1715 EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSE 1774

Query: 261  AETLREQLSSANHS-------------------LQLASQIQKAPDVAIEVLTRSSLE-VE 300
            AE   +      H+                   + + S++ +      + L RS     E
Sbjct: 1775 AEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTE 1834

Query: 301  LAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQ----QLSAKNSTLKQLEEKLKG 356
            +  +  E+  ++    RLQA++ KL E  +   SQLE     Q      + +Q +E  + 
Sbjct: 1835 IDPENEEL--MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATES 1892

Query: 357  QADYEEVKKELNILK------SMEFAPSEGA--GTQDAAKPLEVLLLEKNRSLQSENAAL 408
                EE+++ L+         ++E + +EG   G  D     E  + EK   +      L
Sbjct: 1893 LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1952

Query: 409  RISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEK 468
              +++ L    AE Q           E+REL++R ++ +            G  E +L +
Sbjct: 1953 LCASNRLQELEAEQQ--------QIQEERELLSRQKEAMKA--------EAGPVEQQLLQ 1996

Query: 469  IPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTL 528
              E + +        A      L + QV +L   +  Q  RF    QE   E    +   
Sbjct: 1997 ETEKLMKEKLEVQCQAEKVRDDL-QKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQN 2055

Query: 529  QALQSELDSLR 539
            QAL+ +L+ +R
Sbjct: 2056 QALEKQLEKMR 2066



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 89/470 (18%), Positives = 175/470 (37%), Gaps = 46/470 (9%)

Query: 107  DLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVK-----NQEVTIKALKEKIREYE 161
            DL +QL+ K   +  +  E + L++  E+ +    E++     N+   +++   ++    
Sbjct: 961  DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020

Query: 162  QTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTE 221
              +       A     K+   F E+ + + E ++S  +     E K + L      + T+
Sbjct: 1021 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080

Query: 222  LFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQI 281
               L+     E      E+ ++     ++ Q     Q EA+ +   L  + H  Q+   +
Sbjct: 1081 ESSLRATQPSENDKLQKELNVL-----KSEQNDLRLQMEAQRICLSLVYSTHVDQVREYM 1135

Query: 282  QKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQ------ISQ 335
            +   D A+      SL+ EL   + E  + ++ + +L+    K +E           I +
Sbjct: 1136 ENEKDKAL-----CSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGK 1190

Query: 336  LEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLL 395
            L++ +S + S   Q    + G+     +K E+N     E   + G    +   P      
Sbjct: 1191 LQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNA----EDKENSGDYISENEDPELQDYR 1246

Query: 396  EKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQREL------IARLEQDLSI 449
             + +  Q     L    ++   +   LQ R+++     T+  +L      + + E +   
Sbjct: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 1306

Query: 450  IQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRER 509
            I S      +    H+ +       E T L             E QV  L S+ISS +++
Sbjct: 1307 IHSQMTNLEDIDVNHKSKLSSLQDLEKTKL-------------EEQVQELESLISSLQQQ 1353

Query: 510  FRARNQELEAENRLAQHTLQALQSEL--DSLRADNIKLFEKIKFLQSYPG 557
             +   Q  EAE    Q  LQA+       SL  D++ + E       YPG
Sbjct: 1354 LKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPG 1403


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 105/464 (22%), Positives = 202/464 (43%), Gaps = 59/464 (12%)

Query: 121  DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180
            +++ +  +L++T E   K   E+K  E     L E+    ++ L+ + E  A  +E +++
Sbjct: 853  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912

Query: 181  NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240
               A K+++L+E      ++LEE E + Q LQ   +K   ++ DL+ + +EE  A+    
Sbjct: 913  --LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ--- 967

Query: 241  EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVE 300
                  LE+    A++ + E E L   +   N+ L   S+ +K  +  I  LT +  E E
Sbjct: 968  ---KLQLEKVTAEAKIKKLEDEIL--VMDDQNNKL---SKERKLLEERISDLTTNLAEEE 1019

Query: 301  LAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNST---LKQLEEKLKGQ 357
              AK                +LTKL+    S IS+LE +L  +  +   L++L+ KL+G 
Sbjct: 1020 EKAK----------------NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063

Query: 358  A-DYEE----------------VKKELNILKSMEFAPSEGAGTQDAAKPLEVL---LLEK 397
            A D+ E                 KKE  +  ++     E A   +A K +  L   + + 
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1123

Query: 398  NRSLQSENAALRISNS---DLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSI- 453
               L SE AA   +     DL      L+  + + + +   Q+EL A+ EQ++++++   
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183

Query: 454  --QRPDAEGAAEHRLEKIPEPIKEAT-ALFYGPAAPASGALPEGQVDSLLSIISSQRERF 510
              +    E   +   +K  + ++E T  L     A A+    +  ++   + ++ +    
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243

Query: 511  RARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQS 554
                QE+E + +  +  +Q LQS+         +L +K+  LQ+
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 133/609 (21%), Positives = 255/609 (41%), Gaps = 79/609 (12%)

Query: 17   LQQLQRELDATATVLANRQDESEQSRKRLIE----QSREFKKNTPEDLRKQVAPL---LK 69
            L+QL+ E ++    L + + E++Q+ +R I     Q  + KK   +D    V  L    K
Sbjct: 1338 LRQLEEERNSLQDQL-DEEMEAKQNLERHISTLNIQLSDSKKKL-QDFASTVEALEEGKK 1395

Query: 70   SFQGEIDALSKRSKEAEAAFLNVYK---RLIDVPDPVPALDLGQQLQL-----KVQRLHD 121
             FQ EI+ L+++ +E  AA+  + K   RL    D +  +DL  Q QL     K QR  D
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL-VVDLDNQRQLVSNLEKKQRKFD 1454

Query: 122  IETENQKLRETLEEYNKEFAEVKNQEVTIKAL------------KEKIREYEQTLKNQAE 169
                 +K   +     ++ AE + +E   KAL            KE++    + LK + E
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1514

Query: 170  TIALEKEQKLQNDFA-EKERKLQETQMSTT-SKLEEAEHKVQSLQTALEKTRTELFDLKT 227
             +   K+   +N    EK ++  ETQM    ++LEE E ++Q+ + A  +    +  LK 
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574

Query: 228  KYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQ--------LAS 279
            +++ +  A+ ++ E     L+R     E    +    R   ++A   L+         A 
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634

Query: 280  QIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVED------------VQRLQASLTKLRE 327
               K  + AI+ L +   +++   +E E A+   D             + L+A L +L+E
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694

Query: 328  NSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNI-LKSMEFAPSEGAG---- 382
            + A+     +Q    K    ++L   L G+   ++ K+ L   +  +E    E  G    
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754

Query: 383  --------TQDAAKPLEVLLLEKNRSLQSENAALRIS--NSDLSGRCAELQVRI-TEAVA 431
                    TQ A +    L  E++ + ++E+A  ++   N +L  +  E++  + ++  +
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1814

Query: 432  TATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGAL 491
            T       IA+LE+ +      Q    + AA   L++  + +KE           A    
Sbjct: 1815 TIAALEAKIAQLEEQVE-----QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1869

Query: 492  PEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKF 551
             + +  +      ++ ++ + + +E E E++      + LQ ELD     N  +  ++  
Sbjct: 1870 EQAEKGN------ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923

Query: 552  LQSYPGRGS 560
            L+S   RG+
Sbjct: 1924 LKSKLRRGN 1932



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 115/563 (20%), Positives = 230/563 (40%), Gaps = 82/563 (14%)

Query: 18   QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
            Q+L+ + +   TVL    DE  +S +  +++ R+      E+L +Q+    K  +  +D 
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ-FKRAKANLDK 1224

Query: 78   LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
             +K++ E E A                  DL  +L++  Q   ++E + +KL   ++E  
Sbjct: 1225 -NKQTLEKENA------------------DLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265

Query: 138  KEFAEVKNQEVTIKALKEKIREYEQT---LKNQAETIALEKEQKLQNDFAEKERKLQETQ 194
             + ++ +     +     K++   ++   + N+AE  A+    KL  D A    +LQ+TQ
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI----KLAKDVASLSSQLQDTQ 1321

Query: 195  MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKAD---------------- 238
                  L+E   +  ++ T L +   E   L+ + DEE  AK +                
Sbjct: 1322 ----ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377

Query: 239  -EIEMIMTDLERANQRAEVAQREAETLREQL---SSANHSLQLASQ--IQKAPDVAIEVL 292
             +++   + +E   +  +  Q+E E L +Q    ++A   L+       Q+  D+ +++ 
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437

Query: 293  TRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEE 352
             +  L   L  K+R+  QL+ + + + +     R+ + ++  + E +     S  + LEE
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL---SLARALEE 1494

Query: 353  KLKGQADYEEVKKEL-----NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAA 407
             L+ + + E   K L     +++ S +         + + + LE  + E    L+     
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554

Query: 408  LRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLE 467
            L+ +        A+L++ +         +R+L AR EQ+    + +QR        H  E
Sbjct: 1555 LQATED------AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR------QLHEYE 1602

Query: 468  KIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHT 527
               E  ++  AL    AA A   L     D  L   S+ + R     +E   + R  Q  
Sbjct: 1603 TELEDERKQRAL----AAAAKKKLEGDLKDLELQADSAIKGR-----EEAIKQLRKLQAQ 1653

Query: 528  LQALQSELDSLRADNIKLFEKIK 550
            ++  Q EL+  RA   ++F   K
Sbjct: 1654 MKDFQRELEDARASRDEIFATAK 1676



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 88/368 (23%), Positives = 172/368 (46%), Gaps = 31/368 (8%)

Query: 183  FAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEM 242
            FA+++++L  T M    +   A  K+++ Q     T+ +     T+ +EE  AK DE++ 
Sbjct: 806  FAKRQQQL--TAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ- 862

Query: 243  IMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELA 302
                 +   Q+AE   +E E    QL+   + LQ   Q+Q   ++  E      + V LA
Sbjct: 863  ---KTKERQQKAENELKELEQKHSQLTEEKNLLQ--EQLQAETELYAEA---EEMRVRLA 914

Query: 303  AKEREIAQLVEDVQ-RLQ------ASLTKLRENSASQISQLEQQLSAKNSTLKQLE-EKL 354
            AK++E+ +++ +++ RL+        L   R+  A Q+  LE+QL  + +  ++L+ EK+
Sbjct: 915  AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974

Query: 355  KGQADYEEVKKELNILKSMEFAPS-EGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNS 413
              +A  ++++ E+ ++       S E    ++    L   L E+    ++     ++ N 
Sbjct: 975  TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN---LTKLKNK 1031

Query: 414  DLSGRCAELQVRITEAVATATEQRELIARLEQDLS----IIQSIQRPDAEGAAEHRLEKI 469
              S   +EL+VR+ +   +  E  +L  +LE D S     I  +Q   AE   + +L K 
Sbjct: 1032 HES-MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE--LKMQLAKK 1088

Query: 470  PEPIKEATALFYGPAAPASGALPE-GQVDSLLSIISSQRERFRARNQELEAENRLAQHTL 528
             E ++ A A      A  + AL +  +++  +S +    +  RA   + E + R     L
Sbjct: 1089 EEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1148

Query: 529  QALQSELD 536
            +AL++EL+
Sbjct: 1149 EALKTELE 1156


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 105/464 (22%), Positives = 202/464 (43%), Gaps = 59/464 (12%)

Query: 121  DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180
            +++ +  +L++T E   K   E+K  E     L E+    ++ L+ + E  A  +E +++
Sbjct: 860  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919

Query: 181  NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240
               A K+++L+E      ++LEE E + Q LQ   +K   ++ DL+ + +EE  A+    
Sbjct: 920  --LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ--- 974

Query: 241  EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVE 300
                  LE+    A++ + E E L   +   N+ L   S+ +K  +  I  LT +  E E
Sbjct: 975  ---KLQLEKVTAEAKIKKLEDEIL--VMDDQNNKL---SKERKLLEERISDLTTNLAEEE 1026

Query: 301  LAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNST---LKQLEEKLKGQ 357
              AK                +LTKL+    S IS+LE +L  +  +   L++L+ KL+G 
Sbjct: 1027 EKAK----------------NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070

Query: 358  A-DYEE----------------VKKELNILKSMEFAPSEGAGTQDAAKPLEVL---LLEK 397
            A D+ E                 KKE  +  ++     E A   +A K +  L   + + 
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1130

Query: 398  NRSLQSENAALRISNS---DLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSI- 453
               L SE AA   +     DL      L+  + + + +   Q+EL A+ EQ++++++   
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190

Query: 454  --QRPDAEGAAEHRLEKIPEPIKEAT-ALFYGPAAPASGALPEGQVDSLLSIISSQRERF 510
              +    E   +   +K  + ++E T  L     A A+    +  ++   + ++ +    
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250

Query: 511  RARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQS 554
                QE+E + +  +  +Q LQS+         +L +K+  LQ+
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 133/609 (21%), Positives = 255/609 (41%), Gaps = 79/609 (12%)

Query: 17   LQQLQRELDATATVLANRQDESEQSRKRLIE----QSREFKKNTPEDLRKQVAPL---LK 69
            L+QL+ E ++    L + + E++Q+ +R I     Q  + KK   +D    V  L    K
Sbjct: 1345 LRQLEEERNSLQDQL-DEEMEAKQNLERHISTLNIQLSDSKKKL-QDFASTVEALEEGKK 1402

Query: 70   SFQGEIDALSKRSKEAEAAFLNVYK---RLIDVPDPVPALDLGQQLQL-----KVQRLHD 121
             FQ EI+ L+++ +E  AA+  + K   RL    D +  +DL  Q QL     K QR  D
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL-VVDLDNQRQLVSNLEKKQRKFD 1461

Query: 122  IETENQKLRETLEEYNKEFAEVKNQEVTIKAL------------KEKIREYEQTLKNQAE 169
                 +K   +     ++ AE + +E   KAL            KE++    + LK + E
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1521

Query: 170  TIALEKEQKLQNDFA-EKERKLQETQMSTT-SKLEEAEHKVQSLQTALEKTRTELFDLKT 227
             +   K+   +N    EK ++  ETQM    ++LEE E ++Q+ + A  +    +  LK 
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581

Query: 228  KYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQ--------LAS 279
            +++ +  A+ ++ E     L+R     E    +    R   ++A   L+         A 
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641

Query: 280  QIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVED------------VQRLQASLTKLRE 327
               K  + AI+ L +   +++   +E E A+   D             + L+A L +L+E
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701

Query: 328  NSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNI-LKSMEFAPSEGAG---- 382
            + A+     +Q    K    ++L   L G+   ++ K+ L   +  +E    E  G    
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761

Query: 383  --------TQDAAKPLEVLLLEKNRSLQSENAALRIS--NSDLSGRCAELQVRI-TEAVA 431
                    TQ A +    L  E++ + ++E+A  ++   N +L  +  E++  + ++  +
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821

Query: 432  TATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGAL 491
            T       IA+LE+ +      Q    + AA   L++  + +KE           A    
Sbjct: 1822 TIAALEAKIAQLEEQVE-----QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1876

Query: 492  PEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKF 551
             + +  +      ++ ++ + + +E E E++      + LQ ELD     N  +  ++  
Sbjct: 1877 EQAEKGN------ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930

Query: 552  LQSYPGRGS 560
            L+S   RG+
Sbjct: 1931 LKSKLRRGN 1939



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 115/563 (20%), Positives = 230/563 (40%), Gaps = 82/563 (14%)

Query: 18   QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
            Q+L+ + +   TVL    DE  +S +  +++ R+      E+L +Q+    K  +  +D 
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ-FKRAKANLDK 1231

Query: 78   LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
             +K++ E E A                  DL  +L++  Q   ++E + +KL   ++E  
Sbjct: 1232 -NKQTLEKENA------------------DLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272

Query: 138  KEFAEVKNQEVTIKALKEKIREYEQT---LKNQAETIALEKEQKLQNDFAEKERKLQETQ 194
             + ++ +     +     K++   ++   + N+AE  A+    KL  D A    +LQ+TQ
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI----KLAKDVASLSSQLQDTQ 1328

Query: 195  MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKAD---------------- 238
                  L+E   +  ++ T L +   E   L+ + DEE  AK +                
Sbjct: 1329 ----ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384

Query: 239  -EIEMIMTDLERANQRAEVAQREAETLREQL---SSANHSLQLASQ--IQKAPDVAIEVL 292
             +++   + +E   +  +  Q+E E L +Q    ++A   L+       Q+  D+ +++ 
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444

Query: 293  TRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEE 352
             +  L   L  K+R+  QL+ + + + +     R+ + ++  + E +     S  + LEE
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL---SLARALEE 1501

Query: 353  KLKGQADYEEVKKEL-----NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAA 407
             L+ + + E   K L     +++ S +         + + + LE  + E    L+     
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561

Query: 408  LRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLE 467
            L+ +        A+L++ +         +R+L AR EQ+    + +QR        H  E
Sbjct: 1562 LQATED------AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR------QLHEYE 1609

Query: 468  KIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHT 527
               E  ++  AL    AA A   L     D  L   S+ + R     +E   + R  Q  
Sbjct: 1610 TELEDERKQRAL----AAAAKKKLEGDLKDLELQADSAIKGR-----EEAIKQLRKLQAQ 1660

Query: 528  LQALQSELDSLRADNIKLFEKIK 550
            ++  Q EL+  RA   ++F   K
Sbjct: 1661 MKDFQRELEDARASRDEIFATAK 1683



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 88/368 (23%), Positives = 172/368 (46%), Gaps = 31/368 (8%)

Query: 183  FAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEM 242
            FA+++++L  T M    +   A  K+++ Q     T+ +     T+ +EE  AK DE++ 
Sbjct: 813  FAKRQQQL--TAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ- 869

Query: 243  IMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELA 302
                 +   Q+AE   +E E    QL+   + LQ   Q+Q   ++  E      + V LA
Sbjct: 870  ---KTKERQQKAENELKELEQKHSQLTEEKNLLQ--EQLQAETELYAEA---EEMRVRLA 921

Query: 303  AKEREIAQLVEDVQ-RLQ------ASLTKLRENSASQISQLEQQLSAKNSTLKQLE-EKL 354
            AK++E+ +++ +++ RL+        L   R+  A Q+  LE+QL  + +  ++L+ EK+
Sbjct: 922  AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981

Query: 355  KGQADYEEVKKELNILKSMEFAPS-EGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNS 413
              +A  ++++ E+ ++       S E    ++    L   L E+    ++     ++ N 
Sbjct: 982  TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN---LTKLKNK 1038

Query: 414  DLSGRCAELQVRITEAVATATEQRELIARLEQDLS----IIQSIQRPDAEGAAEHRLEKI 469
              S   +EL+VR+ +   +  E  +L  +LE D S     I  +Q   AE   + +L K 
Sbjct: 1039 HES-MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE--LKMQLAKK 1095

Query: 470  PEPIKEATALFYGPAAPASGALPE-GQVDSLLSIISSQRERFRARNQELEAENRLAQHTL 528
             E ++ A A      A  + AL +  +++  +S +    +  RA   + E + R     L
Sbjct: 1096 EEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1155

Query: 529  QALQSELD 536
            +AL++EL+
Sbjct: 1156 EALKTELE 1163


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 105/464 (22%), Positives = 202/464 (43%), Gaps = 59/464 (12%)

Query: 121  DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180
            +++ +  +L++T E   K   E+K  E     L E+    ++ L+ + E  A  +E +++
Sbjct: 860  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919

Query: 181  NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240
               A K+++L+E      ++LEE E + Q LQ   +K   ++ DL+ + +EE  A+    
Sbjct: 920  --LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ--- 974

Query: 241  EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVE 300
                  LE+    A++ + E E L   +   N+ L   S+ +K  +  I  LT +  E E
Sbjct: 975  ---KLQLEKVTAEAKIKKLEDEIL--VMDDQNNKL---SKERKLLEERISDLTTNLAEEE 1026

Query: 301  LAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNST---LKQLEEKLKGQ 357
              AK                +LTKL+    S IS+LE +L  +  +   L++L+ KL+G 
Sbjct: 1027 EKAK----------------NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070

Query: 358  A-DYEE----------------VKKELNILKSMEFAPSEGAGTQDAAKPLEVL---LLEK 397
            A D+ E                 KKE  +  ++     E A   +A K +  L   + + 
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1130

Query: 398  NRSLQSENAALRISNS---DLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSI- 453
               L SE AA   +     DL      L+  + + + +   Q+EL A+ EQ++++++   
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190

Query: 454  --QRPDAEGAAEHRLEKIPEPIKEAT-ALFYGPAAPASGALPEGQVDSLLSIISSQRERF 510
              +    E   +   +K  + ++E T  L     A A+    +  ++   + ++ +    
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250

Query: 511  RARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQS 554
                QE+E + +  +  +Q LQS+         +L +K+  LQ+
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 115/563 (20%), Positives = 230/563 (40%), Gaps = 82/563 (14%)

Query: 18   QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
            Q+L+ + +   TVL    DE  +S +  +++ R+      E+L +Q+    K  +  +D 
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ-FKRAKANLDK 1231

Query: 78   LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
             +K++ E E A                  DL  +L++  Q   ++E + +KL   ++E  
Sbjct: 1232 -NKQTLEKENA------------------DLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272

Query: 138  KEFAEVKNQEVTIKALKEKIREYEQT---LKNQAETIALEKEQKLQNDFAEKERKLQETQ 194
             + ++ +     +     K++   ++   + N+AE  A+    KL  D A    +LQ+TQ
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI----KLAKDVASLSSQLQDTQ 1328

Query: 195  MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKAD---------------- 238
                  L+E   +  ++ T L +   E   L+ + DEE  AK +                
Sbjct: 1329 ----ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384

Query: 239  -EIEMIMTDLERANQRAEVAQREAETLREQL---SSANHSLQLASQ--IQKAPDVAIEVL 292
             +++   + +E   +  +  Q+E E L +Q    ++A   L+       Q+  D+ +++ 
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444

Query: 293  TRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEE 352
             +  L   L  K+R+  QL+ + + + +     R+ + ++  + E +     S  + LEE
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL---SLARALEE 1501

Query: 353  KLKGQADYEEVKKEL-----NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAA 407
             L+ + + E   K L     +++ S +         + + + LE  + E    L+     
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561

Query: 408  LRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLE 467
            L+ +        A+L++ +         +R+L AR EQ+    + +QR        H  E
Sbjct: 1562 LQATED------AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR------QLHEYE 1609

Query: 468  KIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHT 527
               E  ++  AL    AA A   L     D  L   S+ + R     +E   + R  Q  
Sbjct: 1610 TELEDERKQRAL----AAAAKKKLEGDLKDLELQADSAIKGR-----EEAIKQLRKLQAQ 1660

Query: 528  LQALQSELDSLRADNIKLFEKIK 550
            ++  Q EL+  RA   ++F   K
Sbjct: 1661 MKDFQRELEDARASRDEIFATAK 1683



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 88/368 (23%), Positives = 172/368 (46%), Gaps = 31/368 (8%)

Query: 183  FAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEM 242
            FA+++++L  T M    +   A  K+++ Q     T+ +     T+ +EE  AK DE++ 
Sbjct: 813  FAKRQQQL--TAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ- 869

Query: 243  IMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELA 302
                 +   Q+AE   +E E    QL+   + LQ   Q+Q   ++  E      + V LA
Sbjct: 870  ---KTKERQQKAENELKELEQKHSQLTEEKNLLQ--EQLQAETELYAEA---EEMRVRLA 921

Query: 303  AKEREIAQLVEDVQ-RLQ------ASLTKLRENSASQISQLEQQLSAKNSTLKQLE-EKL 354
            AK++E+ +++ +++ RL+        L   R+  A Q+  LE+QL  + +  ++L+ EK+
Sbjct: 922  AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981

Query: 355  KGQADYEEVKKELNILKSMEFAPS-EGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNS 413
              +A  ++++ E+ ++       S E    ++    L   L E+    ++     ++ N 
Sbjct: 982  TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN---LTKLKNK 1038

Query: 414  DLSGRCAELQVRITEAVATATEQRELIARLEQDLS----IIQSIQRPDAEGAAEHRLEKI 469
              S   +EL+VR+ +   +  E  +L  +LE D S     I  +Q   AE   + +L K 
Sbjct: 1039 HES-MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE--LKMQLAKK 1095

Query: 470  PEPIKEATALFYGPAAPASGALPE-GQVDSLLSIISSQRERFRARNQELEAENRLAQHTL 528
             E ++ A A      A  + AL +  +++  +S +    +  RA   + E + R     L
Sbjct: 1096 EEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1155

Query: 529  QALQSELD 536
            +AL++EL+
Sbjct: 1156 EALKTELE 1163



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 102/479 (21%), Positives = 200/479 (41%), Gaps = 69/479 (14%)

Query: 22   RELDATATVLANRQDESEQSRKRLIEQSREFKK------NTPEDLRKQVAPLLKSFQGEI 75
            RE +  A  LA   +E+ ++++ L   ++  K       ++ +D+ K V  L KS +   
Sbjct: 1486 REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR--- 1542

Query: 76   DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDI-------ETENQK 128
             AL  + +E +     +   L    D    L++  Q  LK Q   D+       E + ++
Sbjct: 1543 -ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA-LKGQFERDLQARDEQNEEKRRQ 1600

Query: 129  LRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKER 188
            L+  L EY  E  + + Q     A K+K+    + L+ QA++    +E+ ++     + R
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK-----QLR 1655

Query: 189  KLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLE 248
            KLQ        +LE+A             +R E+F    + +++  +   ++  +  DL 
Sbjct: 1656 KLQAQMKDFQRELEDAR-----------ASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704

Query: 249  RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREI 308
             A +  + A  E E L E+L+S+                   +  R++L+ E    E  I
Sbjct: 1705 AAERARKQADLEKEELAEELASS-------------------LSGRNALQDEKRRLEARI 1745

Query: 309  AQLVEDVQRLQASLTKLRE---NSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKK 365
            AQL E+++  Q ++  + +    +  Q  QL  +L+ + ST ++ E     +   E   K
Sbjct: 1746 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE---SARQQLERQNK 1802

Query: 366  EL-NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQS-ENAALRISNSDLSGRCAELQ 423
            EL + L  ME A      +  AA   ++  LE+    ++ E  A   S      +  E+ 
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862

Query: 424  VRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHR-----LEKIPEPIKEAT 477
            +++ +    A + +E   + E+  + ++ ++R   E   E +       K+   + EAT
Sbjct: 1863 LQVEDERKMAEQYKE---QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1918


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 105/464 (22%), Positives = 202/464 (43%), Gaps = 59/464 (12%)

Query: 121  DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180
            +++ +  +L++T E   K   E+K  E     L E+    ++ L+ + E  A  +E +++
Sbjct: 853  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912

Query: 181  NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240
               A K+++L+E      ++LEE E + Q LQ   +K   ++ DL+ + +EE  A+    
Sbjct: 913  --LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ--- 967

Query: 241  EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVE 300
                  LE+    A++ + E E L   +   N+ L   S+ +K  +  I  LT +  E E
Sbjct: 968  ---KLQLEKVTAEAKIKKLEDEIL--VMDDQNNKL---SKERKLLEERISDLTTNLAEEE 1019

Query: 301  LAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNST---LKQLEEKLKGQ 357
              AK                +LTKL+    S IS+LE +L  +  +   L++L+ KL+G 
Sbjct: 1020 EKAK----------------NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063

Query: 358  A-DYEE----------------VKKELNILKSMEFAPSEGAGTQDAAKPLEVL---LLEK 397
            A D+ E                 KKE  +  ++     E A   +A K +  L   + + 
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1123

Query: 398  NRSLQSENAALRISNS---DLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSI- 453
               L SE AA   +     DL      L+  + + + +   Q+EL A+ EQ++++++   
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183

Query: 454  --QRPDAEGAAEHRLEKIPEPIKEAT-ALFYGPAAPASGALPEGQVDSLLSIISSQRERF 510
              +    E   +   +K  + ++E T  L     A A+    +  ++   + ++ +    
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243

Query: 511  RARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQS 554
                QE+E + +  +  +Q LQS+         +L +K+  LQ+
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 115/563 (20%), Positives = 230/563 (40%), Gaps = 82/563 (14%)

Query: 18   QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
            Q+L+ + +   TVL    DE  +S +  +++ R+      E+L +Q+    K  +  +D 
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ-FKRAKANLDK 1224

Query: 78   LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
             +K++ E E A                  DL  +L++  Q   ++E + +KL   ++E  
Sbjct: 1225 -NKQTLEKENA------------------DLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265

Query: 138  KEFAEVKNQEVTIKALKEKIREYEQT---LKNQAETIALEKEQKLQNDFAEKERKLQETQ 194
             + ++ +     +     K++   ++   + N+AE  A+    KL  D A    +LQ+TQ
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI----KLAKDVASLSSQLQDTQ 1321

Query: 195  MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKAD---------------- 238
                  L+E   +  ++ T L +   E   L+ + DEE  AK +                
Sbjct: 1322 ----ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377

Query: 239  -EIEMIMTDLERANQRAEVAQREAETLREQL---SSANHSLQLASQ--IQKAPDVAIEVL 292
             +++   + +E   +  +  Q+E E L +Q    ++A   L+       Q+  D+ +++ 
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437

Query: 293  TRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEE 352
             +  L   L  K+R+  QL+ + + + +     R+ + ++  + E +     S  + LEE
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL---SLARALEE 1494

Query: 353  KLKGQADYEEVKKEL-----NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAA 407
             L+ + + E   K L     +++ S +         + + + LE  + E    L+     
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554

Query: 408  LRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLE 467
            L+ +        A+L++ +         +R+L AR EQ+    + +QR        H  E
Sbjct: 1555 LQATED------AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR------QLHEYE 1602

Query: 468  KIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHT 527
               E  ++  AL    AA A   L     D  L   S+ + R     +E   + R  Q  
Sbjct: 1603 TELEDERKQRAL----AAAAKKKLEGDLKDLELQADSAIKGR-----EEAIKQLRKLQAQ 1653

Query: 528  LQALQSELDSLRADNIKLFEKIK 550
            ++  Q EL+  RA   ++F   K
Sbjct: 1654 MKDFQRELEDARASRDEIFATAK 1676



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 88/368 (23%), Positives = 172/368 (46%), Gaps = 31/368 (8%)

Query: 183  FAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEM 242
            FA+++++L  T M    +   A  K+++ Q     T+ +     T+ +EE  AK DE++ 
Sbjct: 806  FAKRQQQL--TAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ- 862

Query: 243  IMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELA 302
                 +   Q+AE   +E E    QL+   + LQ   Q+Q   ++  E      + V LA
Sbjct: 863  ---KTKERQQKAENELKELEQKHSQLTEEKNLLQ--EQLQAETELYAEA---EEMRVRLA 914

Query: 303  AKEREIAQLVEDVQ-RLQ------ASLTKLRENSASQISQLEQQLSAKNSTLKQLE-EKL 354
            AK++E+ +++ +++ RL+        L   R+  A Q+  LE+QL  + +  ++L+ EK+
Sbjct: 915  AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974

Query: 355  KGQADYEEVKKELNILKSMEFAPS-EGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNS 413
              +A  ++++ E+ ++       S E    ++    L   L E+    ++     ++ N 
Sbjct: 975  TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN---LTKLKNK 1031

Query: 414  DLSGRCAELQVRITEAVATATEQRELIARLEQDLS----IIQSIQRPDAEGAAEHRLEKI 469
              S   +EL+VR+ +   +  E  +L  +LE D S     I  +Q   AE   + +L K 
Sbjct: 1032 HES-MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE--LKMQLAKK 1088

Query: 470  PEPIKEATALFYGPAAPASGALPE-GQVDSLLSIISSQRERFRARNQELEAENRLAQHTL 528
             E ++ A A      A  + AL +  +++  +S +    +  RA   + E + R     L
Sbjct: 1089 EEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1148

Query: 529  QALQSELD 536
            +AL++EL+
Sbjct: 1149 EALKTELE 1156



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 102/479 (21%), Positives = 200/479 (41%), Gaps = 69/479 (14%)

Query: 22   RELDATATVLANRQDESEQSRKRLIEQSREFKK------NTPEDLRKQVAPLLKSFQGEI 75
            RE +  A  LA   +E+ ++++ L   ++  K       ++ +D+ K V  L KS +   
Sbjct: 1479 REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR--- 1535

Query: 76   DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDI-------ETENQK 128
             AL  + +E +     +   L    D    L++  Q  LK Q   D+       E + ++
Sbjct: 1536 -ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA-LKGQFERDLQARDEQNEEKRRQ 1593

Query: 129  LRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKER 188
            L+  L EY  E  + + Q     A K+K+    + L+ QA++    +E+ ++     + R
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK-----QLR 1648

Query: 189  KLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLE 248
            KLQ        +LE+A             +R E+F    + +++  +   ++  +  DL 
Sbjct: 1649 KLQAQMKDFQRELEDAR-----------ASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697

Query: 249  RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREI 308
             A +  + A  E E L E+L+S+                   +  R++L+ E    E  I
Sbjct: 1698 AAERARKQADLEKEELAEELASS-------------------LSGRNALQDEKRRLEARI 1738

Query: 309  AQLVEDVQRLQASLTKLRE---NSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKK 365
            AQL E+++  Q ++  + +    +  Q  QL  +L+ + ST ++ E     +   E   K
Sbjct: 1739 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE---SARQQLERQNK 1795

Query: 366  EL-NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQS-ENAALRISNSDLSGRCAELQ 423
            EL + L  ME A      +  AA   ++  LE+    ++ E  A   S      +  E+ 
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855

Query: 424  VRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHR-----LEKIPEPIKEAT 477
            +++ +    A + +E   + E+  + ++ ++R   E   E +       K+   + EAT
Sbjct: 1856 LQVEDERKMAEQYKE---QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1911


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
           sapiens]
          Length = 1116

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 127/569 (22%), Positives = 244/569 (42%), Gaps = 73/569 (12%)

Query: 1   MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL 60
           + A +G + Q   R D + L   L      L N+  +S+Q  + L E             
Sbjct: 464 LQAEIGQVKQELSRKDTELLA--LQTKLETLTNQFSDSKQHIEVLKESLTA--------- 512

Query: 61  RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPAL-----DLGQQLQLK 115
           ++Q A +L   Q E+DAL  R +E E       K++ D+ +          DL   L +K
Sbjct: 513 KEQRAAIL---QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569

Query: 116 VQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEK 175
            ++++ ++ + + L+E L +  K+ + +K +   +K+L+      +  L    E +A EK
Sbjct: 570 ERKVNVLQKKIENLQEQLRDKEKQMSSLKER---VKSLQADTTNTDTALTTLEEALA-EK 625

Query: 176 E---QKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEE 232
           E   ++L+      ER+ QE   +    L++ + KV  LQ  L +    L DLK      
Sbjct: 626 ERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK------ 679

Query: 233 TTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVL 292
                +    + +   + + R +  +   E  +E+       L++ SQ++KA + A+E  
Sbjct: 680 -----EHASSLASSGLKKDSRLKTLEIALEQKKEEC------LKMESQLKKAHEAALEAR 728

Query: 293 TRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRE----------NSASQISQLEQQLSA 342
               +   +   EREI +  ++  + QA + +L E          +   +I++LE+Q+  
Sbjct: 729 ASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKD 788

Query: 343 KNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQ 402
           +N  +  L+ K       E+V+K+ +  + +E A        D+++ L+  L +K+  ++
Sbjct: 789 QNKKVANLKHK-------EQVEKKKS-AQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 840

Query: 403 SENAALRISNSDLSGRCAELQVRITEAVATATEQR--ELIARLE---QDLSIIQSIQRPD 457
               ALR S    + R  E+ +   E+  T  E++  EL+  +E   Q+L  +++     
Sbjct: 841 ELEEALRESVQITAER--EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSST 898

Query: 458 AEGAAE---HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARN 514
            +  AE   H      E  K    +          A+ E   +  L  +SS +++ +   
Sbjct: 899 QQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEV 958

Query: 515 QELEAE-NRLAQHTLQALQSELDSLRADN 542
             L+ E +RL Q   Q  Q+ +  L ADN
Sbjct: 959 AALKREKDRLVQQLKQQTQNRM-KLMADN 986



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 88/439 (20%), Positives = 179/439 (40%), Gaps = 53/439 (12%)

Query: 132 TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE--QKLQNDFAEK--E 187
           T E + +  AE + Q   +  L++ + E E  ++ Q +T+    E  +KL      K   
Sbjct: 263 TEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLS 322

Query: 188 RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDE--ETTAKADEIEMIMT 245
            K  E     T +L EAE  V  L++ LE+   E   L+ +     E    + + + + T
Sbjct: 323 AKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQT 382

Query: 246 DLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSS--------- 296
            +E  + +    +R    L E++     +  L+++ ++     +EV    S         
Sbjct: 383 VIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQ 442

Query: 297 LEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG 356
           L+ EL++KE +  +L +    LQA           +I Q++Q+LS K++ L  L+ KL+ 
Sbjct: 443 LKEELSSKEAQWEELKKKAAGLQA-----------EIGQVKQELSRKDTELLALQTKLET 491

Query: 357 QAD-YEEVKKELNILK-SMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSD 414
             + + + K+ + +LK S+       A  Q     L + L EK   L  +   ++    +
Sbjct: 492 LTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEE 551

Query: 415 LSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIK 474
              +  E+            + ++++   E+ ++++Q           E+  E++ +  K
Sbjct: 552 KGTQAGEIH-----------DLKDMLDVKERKVNVLQK--------KIENLQEQLRDKEK 592

Query: 475 EATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSE 534
           + ++L        S        D+ L+ +    E    + + +E          +  Q E
Sbjct: 593 QMSSL---KERVKSLQADTTNTDTALTTL---EEALAEKERTIERLKEQRDRDEREKQEE 646

Query: 535 LDSLRADNIKLFEKIKFLQ 553
           +D+ + D   L EK+  LQ
Sbjct: 647 IDNYKKDLKDLKEKVSLLQ 665



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 58/317 (18%), Positives = 132/317 (41%), Gaps = 27/317 (8%)

Query: 17   LQQLQRELDATATVLANRQDESEQSRKR---LIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
            + +L+R++      +AN + + +  +K+   ++E++R  + N   D  +Q+   L+    
Sbjct: 779  IAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNL-NDSSQQLQDSLRKKDD 837

Query: 74   EIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETL 133
             I+ L +  +E+    +   + ++   +     +  +Q++  +  +  ++ E + ++  L
Sbjct: 838  RIEELEEALRESVQ--ITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKL 895

Query: 134  EEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQET 193
                +  AE +     ++A + K  E    +K +A   A+  E+       E     ++T
Sbjct: 896  SSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS-EKDANIALLELSSSKKKT 954

Query: 194  QMSTTSKLEEAEHKVQSLQTALEKTRTELFD------LKTKYDEETTAKADEIEMIMTDL 247
            Q    +   E +  VQ L+   +     + D       K+ +  +T  K    ++I   L
Sbjct: 955  QEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLL 1014

Query: 248  ERANQRAEVA-----------QREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSS 296
            E    R+++             R+   LR     A+++L      Q A +  ++ +TR  
Sbjct: 1015 ELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLD---DDQAAWENELQKMTRGQ 1071

Query: 297  LEVELAAKEREIAQLVE 313
            L+ EL   ER+ A+L E
Sbjct: 1072 LQDELEKGERDNAELQE 1088


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 131/595 (22%), Positives = 242/595 (40%), Gaps = 86/595 (14%)

Query: 35   QDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYK 94
            Q + E +R + +EQS  F+K   + L++++     +   E   + +  K+       V +
Sbjct: 458  QTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAE 517

Query: 95   RLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVK--------NQ 146
                +    PA D+   L L    L +I +  +KL  T  ++ +E   +K          
Sbjct: 518  LRRRLESNKPAGDVDMSLSL----LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETH 573

Query: 147  EVTIKAL---KEKIREYEQTLKNQAE--------TIALEKEQKLQNDFAEKERKLQETQM 195
            +  IKAL    EK+ +  ++LK++ E         IAL K  KL+   A  ++ ++E ++
Sbjct: 574  QKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK-SKLETAIASHQQAMEELKV 632

Query: 196  STTSKLEEAEHKVQSLQTALEKTRT----ELFDLKTKYDEETTAKADEIEMIMTDLERAN 251
            S +  L     +   L+T +EK R     E+ +L+ + D E  A A E+E +   L +  
Sbjct: 633  SFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVI 692

Query: 252  QRAEVAQREAETLREQLSSA--NHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIA 309
            +  E      E +R +L  A   H +++   + K  +  I+V     LEV L AK  E  
Sbjct: 693  KEKE---NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKV---KELEV-LQAKCNEQT 745

Query: 310  QLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNI 369
            +++++      S  K  E     +  L +  S   S +K+L ++L+     E+  K L I
Sbjct: 746  KVIDNF----TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA---EKQIKHLEI 798

Query: 370  LKSMEFAPSEGAGTQDAAKPLEVLLLEKNRS--------LQSENAALRISNSDLSGRCAE 421
             K+ E + +     +   + L++  L++N S        L+ E   L+   ++ S     
Sbjct: 799  EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVS 858

Query: 422  LQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFY 481
            +Q  + E V    ++ E    L  DL  ++     D E     + E+  + IK    L  
Sbjct: 859  VQRSMQETVNKLHQKEEQFNMLSSDLEKLRE-NLADMEAKFREKDEREEQLIKAKEKL-- 915

Query: 482  GPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRAD 541
                       E  +  ++ +      +    N EL    RL +  ++ LQ +L      
Sbjct: 916  -----------ENDIAEIMKMSGDNSSQLTKMNDEL----RLKERDVEELQLKL------ 954

Query: 542  NIKLFEKIKFLQ-SYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSL 595
              K  E   FLQ S       ++ ++   + ++EE         K+E +RK   L
Sbjct: 955  -TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE--------EKKELERKLSDL 1000



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 110/588 (18%), Positives = 251/588 (42%), Gaps = 91/588 (15%)

Query: 58   EDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ 117
            E LR ++  ++K  +  ++A+  +  +AE       + L+++ D +  L   Q+ ++KV+
Sbjct: 682  EALRAKLMKVIKEKENSLEAIRSKLDKAED------QHLVEMEDTLNKL---QEAEIKVK 732

Query: 118  RLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQ 177
             L  ++ +  +  + ++ +  +          +KA +EK+ + +   K  +E  +  K+ 
Sbjct: 733  ELEVLQAKCNEQTKVIDNFTSQ----------LKATEEKLLDLDALRKASSEGKSEMKKL 782

Query: 178  KLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK- 236
            + Q + AEK+ K  E + +  S       K  S+   L+    +L +L+    E +  K 
Sbjct: 783  RQQLEAAEKQIKHLEIEKNAESS------KASSITRELQGRELKLTNLQENLSEVSQVKE 836

Query: 237  --ADEIEMIMTDLERANQRAEVAQRE-AETLREQLSSANHSLQLASQIQKAPDVAIEVLT 293
                E++++      A++ A   QR   ET+ +          L+S ++K  +       
Sbjct: 837  TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE------N 890

Query: 294  RSSLEVELAAKEREIAQLVEDVQRLQ---ASLTKLRENSASQISQLEQQLSAKNSTLKQL 350
             + +E +   K+    QL++  ++L+   A + K+  +++SQ++++  +L  K   +++L
Sbjct: 891  LADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEEL 950

Query: 351  EEKL-KGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALR 409
            + KL K   +   ++K +      +         Q+AAK  E    E+ + L+ + + L 
Sbjct: 951  QLKLTKANENASFLQKSIE-----DMTVKAEQSQQEAAKKHE----EEKKELERKLSDLE 1001

Query: 410  ISNSDLSGRCAELQVRITEAVA-TATEQRELIARL---------------EQDLSIIQSI 453
                    +C EL+ R   A + T T+  E++  L               E++  ++Q +
Sbjct: 1002 KKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL 1061

Query: 454  Q-------RPDAEGAAEHRLEKIPEPIKEAT-ALFYGPAAPASGALPEGQVDSL------ 499
            +       +  A   AE  ++ + +  KE T  L        + A  + ++D+L      
Sbjct: 1062 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK 1121

Query: 500  -LSIISSQRERFRARNQELEAENRLAQHTLQAL---QSELDSLRADNIKLFEKIKFLQSY 555
             +  ++  +E     NQ++E   +  +   QA      +L +L+ +N+KL E++      
Sbjct: 1122 NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL------ 1175

Query: 556  PGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATL 603
               G   D+       + E  +        ++R+ K++  +  +KA+L
Sbjct: 1176 ---GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASL 1220



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 115/586 (19%), Positives = 246/586 (41%), Gaps = 93/586 (15%)

Query: 16   DLQQLQRELDATATVLANRQDE--SEQSRKRLIE---QSREFKKNTPEDLRKQVAPLLKS 70
            ++++L+++L+A    + + + E  +E S+   I    Q RE K    ++   +V+ + ++
Sbjct: 778  EMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET 837

Query: 71   FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLR 130
             + E+  L ++  EA    ++V + + +  +         +L  K ++ + + ++ +KLR
Sbjct: 838  LEKELQILKEKFAEASEEAVSVQRSMQETVN---------KLHQKEEQFNMLSSDLEKLR 888

Query: 131  ETLEEYNKEFAEVKNQEVTIKALKEKIR-EYEQTLKNQAETIALEKEQKLQNDFAEKERK 189
            E L +   +F E   +E  +   KEK+  +  + +K   +  +  +  K+ ++   KER 
Sbjct: 889  ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS--QLTKMNDELRLKERD 946

Query: 190  LQETQMSTTSKLEEA--------------------------------EHKVQSLQTALEK 217
            ++E Q+  T   E A                                E K+  L+  +E 
Sbjct: 947  VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMET 1006

Query: 218  TRTELFDLKTKYDEETTAKADEIEMIMTDLER----ANQRAEVAQREAETLREQLSSANH 273
            +  +  +LK +Y+  T+    + E I+ +L++       + + A+ E   L ++L     
Sbjct: 1007 SHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK 1066

Query: 274  SLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQ---RLQASLTKLRENSA 330
                A   Q A D A++++ + + E     K   +A L +  Q   +LQ  L  L+EN+ 
Sbjct: 1067 QADKAKAAQTAED-AMQIMEQMTKE-----KTETLASLEDTKQTNAKLQNELDTLKENNL 1120

Query: 331  SQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPL 390
              + +L      K+  L  +E +       EE +KE+  LK      S+           
Sbjct: 1121 KNVEELN-----KSKELLTVENQ-----KMEEFRKEIETLKQAAAQKSQQLSALQEENVK 1170

Query: 391  EVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSII 450
                L ++R   + +  L    S L+ +  E++ R ++ +  A E++   A L++ +SI 
Sbjct: 1171 LAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK---ASLQKSISIT 1227

Query: 451  QS-IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRER 509
             + +   DAE      LEK    ++    +  G  A A        + S++  + S + +
Sbjct: 1228 SALLTEKDAE------LEK----LRNEVTVLRGENASAK------SLHSVVQTLESDKVK 1271

Query: 510  FRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFE-KIKFLQS 554
               + + LE + +  +  L +     D+   ++ +  E +I FL S
Sbjct: 1272 LELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNS 1317



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 98/485 (20%), Positives = 197/485 (40%), Gaps = 57/485 (11%)

Query: 115 KVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTL---KNQAETI 171
           KV+ L+ +E E +K+ +      +E     + E   K    +I+E EQ+L   K +A+ +
Sbjct: 424 KVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKL 483

Query: 172 ALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTR-TELFDLKTKYD 230
             E E       +EK R + E +     +++E    V  L+  LE  +     D+     
Sbjct: 484 QRELEDTRVATVSEKSR-IMELEKDLALRVQE----VAELRRRLESNKPAGDVDMSLSLL 538

Query: 231 EETTAKADEIEMIMTDLERA--------NQRAEVAQREAE---TLREQLSSANHSLQLAS 279
           +E ++  +++E+  TD +R           R E  Q+E +   T  E+LS  N SL+   
Sbjct: 539 QEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL 598

Query: 280 QIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQ 339
           +     +  +  L +S LE  +A+ +       + ++ L+ S +K      ++ ++L+ Q
Sbjct: 599 EHANKENSDVIALWKSKLETAIASHQ-------QAMEELKVSFSKGLGTETAEFAELKTQ 651

Query: 340 LSAKNSTLKQLEEKLKGQADYEEV--KKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 397
           +       +   E L+ Q D E     KE+  L++      +       A   ++   E 
Sbjct: 652 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 711

Query: 398 NRSLQSENAALRISNSDLSGRCAE-LQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 456
              ++ E+   ++  +++  +  E LQ +  E           +   E+ L  + ++++ 
Sbjct: 712 QHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKA 771

Query: 457 DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSL--------LSII 503
            +EG +E      +LE   + IK         ++ AS    E Q   L        LS +
Sbjct: 772 SSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEV 831

Query: 504 SS-----------QRERFRARNQELEAENRLAQHTLQAL---QSELDSLRADNIKLFEKI 549
           S             +E+F   ++E  +  R  Q T+  L   + + + L +D  KL E +
Sbjct: 832 SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 891

Query: 550 KFLQS 554
             +++
Sbjct: 892 ADMEA 896



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 75/328 (22%), Positives = 136/328 (41%), Gaps = 41/328 (12%)

Query: 129 LRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTL-----------KNQAETIALEKEQ 177
           L ET   Y ++   +       +ALKEK +  EQ L           K  +    +E+E 
Sbjct: 336 LTETSSRYARK---ISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQEL 392

Query: 178 KLQNDFAEKERKLQETQMSTT-SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK 236
            L  D  ++     E +M    + +E A+ +   L   LE+ + ++ DL+ + +EE+  K
Sbjct: 393 ALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITK 452

Query: 237 AD----------EIEMIMTDLERANQRAEVAQREAE-----TLREQLSSANHSLQLASQI 281
            D           I+ +   L     +A+  QRE E     T+ E+         LA ++
Sbjct: 453 GDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRV 512

Query: 282 QKAPDVAIEVLTRSSLEVELAAKEREIA-QLVEDVQRLQASLTKLRENSASQISQLEQQL 340
           Q+  ++      R  LE    A + +++  L++++  LQ  L   R +   +I+ L++  
Sbjct: 513 QEVAEL------RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF 566

Query: 341 SAKNSTLKQLEEKLKGQADYEEVKKELNILKS-MEFAPSEGAGTQDAAK-PLEVLLLEKN 398
            A+  T  Q E K    A  E++ KE   LKS +E A  E +      K  LE  +    
Sbjct: 567 GAREET-HQKEIKALYTAT-EKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQ 624

Query: 399 RSLQSENAALRISNSDLSGRCAELQVRI 426
           ++++    +        +   AEL+ +I
Sbjct: 625 QAMEELKVSFSKGLGTETAEFAELKTQI 652


>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
          Length = 1088

 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 124/553 (22%), Positives = 242/553 (43%), Gaps = 65/553 (11%)

Query: 19  QLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL--RKQVAPLLKSFQGEID 76
           Q+++EL    T L   Q + E    +  + S++  +   E L  ++Q A +L   Q E+D
Sbjct: 442 QVKQELSRKDTELLALQTKLETLTNQFSD-SKQHIEVLKESLTAKEQRAAIL---QTEVD 497

Query: 77  ALSKRSKEAEAAFLNVYKRLIDVPDPVPAL-----DLGQQLQLKVQRLHDIETENQKLRE 131
           AL  R +E E       K++ D+ +          DL   L +K ++++ ++ + + L+E
Sbjct: 498 ALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE 557

Query: 132 TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE---QKLQNDFAEKER 188
            L +  K+ + +K +   +K+L+      +  L    E +A EKE   ++L+      ER
Sbjct: 558 QLRDKEKQMSSLKER---VKSLQADTTNTDTALTTLEEALA-EKERTIERLKEQRDRDER 613

Query: 189 KLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLE 248
           + QE   +    L++ + KV  LQ  L +    L DLK           +    + +   
Sbjct: 614 EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK-----------EHASSLASSGL 662

Query: 249 RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREI 308
           + + R +  +   E  +E+       L++ SQ++KA + A+E      +   +   EREI
Sbjct: 663 KKDSRLKTLEIALEQKKEEC------LKMESQLKKAHEAALEARASPEMSDRIQHLEREI 716

Query: 309 AQLVEDVQRLQASLTKLRE----------NSASQISQLEQQLSAKNSTLKQLEEKLKGQA 358
            +  ++  + QA + +L E          +   +I++LE+Q+  +N  +  L+ K     
Sbjct: 717 TRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK----- 771

Query: 359 DYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGR 418
             E+V+K+ +  + +E A        D+++ L+  L +K+  ++    ALR S    + R
Sbjct: 772 --EQVEKKKS-AQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAER 828

Query: 419 CAELQVRITEAVATATEQR--ELIARLE---QDLSIIQSIQRPDAEGAAE---HRLEKIP 470
             E+ +   E+  T  E++  EL+  +E   Q+L  +++      +  AE   H      
Sbjct: 829 --EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRA 886

Query: 471 EPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAE-NRLAQHTLQ 529
           E  K    +          A+ E   +  L  +SS +++ +     L+ E +RL Q   Q
Sbjct: 887 ERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ 946

Query: 530 ALQSELDSLRADN 542
             Q+ +  L ADN
Sbjct: 947 QTQNRM-KLMADN 958



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 96/403 (23%), Positives = 176/403 (43%), Gaps = 59/403 (14%)

Query: 119 LHDIETENQKLRETLE---EYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEK 175
           L   E EN  LRE +    E   + A+ K  +  I+    KI   E+ L++  E I + K
Sbjct: 350 LEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLK 409

Query: 176 EQ-KLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETT 234
               L  +  E+E K  E   S +  ++   +K+  ++  L +  TEL  L+TK +  T 
Sbjct: 410 SNGALSTEEREEEMKQMEVYRSHSKFMK---NKIGQVKQELSRKDTELLALQTKLETLTN 466

Query: 235 AKAD---EIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQ--------------- 276
             +D    IE++   L    QRA + Q E + LR +L      L                
Sbjct: 467 QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 526

Query: 277 LASQIQKAPDV------AIEVLTR--SSLEVELAAKEREIAQLVEDVQRLQASLTKLREN 328
            A +I    D+       + VL +   +L+ +L  KE++++ L E V+ LQA  T    N
Sbjct: 527 QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT----N 582

Query: 329 SASQISQLEQQLSAKNSTLKQLEE-----KLKGQADYEEVKKELNILKSMEFAPSEGAGT 383
           + + ++ LE+ L+ K  T+++L+E     + + Q + +  KK+L  LK  + +  +G  +
Sbjct: 583 TDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKE-KVSLLQGDLS 641

Query: 384 QDAAKPLEV-----LLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQR- 437
           +  A  L++      L        S    L I+       C +++ ++ +A   A E R 
Sbjct: 642 EKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARA 701

Query: 438 -----ELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKE 475
                + I  LE++++     +  D    A+  ++++ E +KE
Sbjct: 702 SPEMSDRIQHLEREIT-----RYKDESSKAQAEVDRLLEILKE 739



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 58/317 (18%), Positives = 132/317 (41%), Gaps = 27/317 (8%)

Query: 17   LQQLQRELDATATVLANRQDESEQSRKR---LIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
            + +L+R++      +AN + + +  +K+   ++E++R  + N   D  +Q+   L+    
Sbjct: 751  IAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNL-NDSSQQLQDSLRKKDD 809

Query: 74   EIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETL 133
             I+ L +  +E+    +   + ++   +     +  +Q++  +  +  ++ E + ++  L
Sbjct: 810  RIEELEEALRESVQ--ITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKL 867

Query: 134  EEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQET 193
                +  AE +     ++A + K  E    +K +A   A+  E+       E     ++T
Sbjct: 868  SSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS-EKDANIALLELSSSKKKT 926

Query: 194  QMSTTSKLEEAEHKVQSLQTALEKTRTELFD------LKTKYDEETTAKADEIEMIMTDL 247
            Q    +   E +  VQ L+   +     + D       K+ +  +T  K    ++I   L
Sbjct: 927  QEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLL 986

Query: 248  ERANQRAEVA-----------QREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSS 296
            E    R+++             R+   LR     A+++L      Q A +  ++ +TR  
Sbjct: 987  ELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLD---DDQAAWENELQKMTRGQ 1043

Query: 297  LEVELAAKEREIAQLVE 313
            L+ EL   ER+ A+L E
Sbjct: 1044 LQDELEKGERDNAELQE 1060


>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
          Length = 1139

 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 86/351 (24%), Positives = 149/351 (42%), Gaps = 49/351 (13%)

Query: 154 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 212
           +E +R   + L+ + ET+ L++ E K +    EK +   E      SK++E +  +Q   
Sbjct: 83  EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142

Query: 213 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 272
               K   E  + K +Y EE    AD IEM   D E A +RAE  Q+E E L+E++    
Sbjct: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 202

Query: 273 HSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSAS- 331
             L++         +  E+  + S   + AA   ++ QL E   RL+ +L ++R+ S+S 
Sbjct: 203 TDLEI---------LKAEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSSSE 250

Query: 332 -----------------------QISQLEQQLSAKNSTLKQLEEKLKGQADYEEV----- 363
                                  Q  +L+++LS   ST+ +L+E++      EE+     
Sbjct: 251 KQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310

Query: 364 KKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQ 423
            + LN+ + +     E  G  +A   +   L E  R  + E   LR        R  E Q
Sbjct: 311 DRNLNLEEKVR-ELRETVGDLEAMNEMNDELQENARETELE---LREQLDMAGARVREAQ 366

Query: 424 VRITEAVATATEQRELIARLEQDLSIIQSIQRP---DAEGAAEHRLEKIPE 471
            R+  A  T  + ++ I +  Q  + +Q + R      E + E + +  PE
Sbjct: 367 KRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 417



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 87/410 (21%), Positives = 173/410 (42%), Gaps = 43/410 (10%)

Query: 66  PLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQ---QLQLKVQRLHDI 122
           P+L S  G +  L   SKE E     V     D+ + +  L L +   + +LK    H I
Sbjct: 65  PVLTS-PGAVPPLPSPSKEEEGLRAQVR----DLEEKLETLRLKRAEDKAKLKELEKHKI 119

Query: 123 ETEN-----QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE- 176
           + E       K++E   +  +   E + +       KE+  E      +  E   L+KE 
Sbjct: 120 QLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEM 179

Query: 177 -----QKLQNDFAEKERKLQETQMSTTSKLEEAEHK-----VQSLQ-TALEKTRTELFDL 225
                + LQ +    + ++ E          E E K       S Q   LE+    L D 
Sbjct: 180 AEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDA 239

Query: 226 KTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKA 284
             +  + ++++  E   +   +E+ NQ  EV +++ E L+E+LS A  ++ +L  Q+  A
Sbjct: 240 LVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 299

Query: 285 --PDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSA 342
              +  +E+LT  +L +E   K RE+ + V D++ +     +L+EN+     +L +QL  
Sbjct: 300 LGAEEMVEMLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 357

Query: 343 KNSTLKQLEEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 397
             + +++ +++++      ADY++ +KK   +   ++    E    Q+A+       +E+
Sbjct: 358 AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS-------VER 410

Query: 398 NRSLQSENAALRISNSDLSGRCAELQVRITE-AVATATEQRELIARLEQD 446
            +    E    +I  ++       +++ + +  VA A     L+     D
Sbjct: 411 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPD 460



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 62/303 (20%), Positives = 125/303 (41%), Gaps = 32/303 (10%)

Query: 26  ATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ--GEIDALS---- 79
           A A  +A    E  + R   ++Q  E  K   ++L   +  L    +  G   A S    
Sbjct: 167 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL 226

Query: 80  KRSKEAEAAFLNVYKRLIDVP--DPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
           K+ +E  A   +   R+ D+   +    + L + ++ K Q L  +  + ++L+E L +  
Sbjct: 227 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE 286

Query: 138 KEFAEVKNQ-------EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKL 190
               E+K Q       E  ++ L ++    E+ ++   ET+   +     ND  E +   
Sbjct: 287 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMND--ELQENA 344

Query: 191 QETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER- 249
           +ET++    +L+ A  +V+  Q  +E  +  + D      ++T  K  ++   + D+ R 
Sbjct: 345 RETELELREQLDMAGARVREAQKRVEAAQETVADY-----QQTIKKYRQLTAHLQDVNRE 399

Query: 250 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREI 308
             NQ+    +R+     +Q        ++     KA   AIE+  R   ++E+A   R +
Sbjct: 400 LTNQQEASVERQ-----QQPPPETFDFKIKFAETKAHAKAIEMELR---QMEVAQANRHM 451

Query: 309 AQL 311
           + L
Sbjct: 452 SLL 454



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 13/180 (7%)

Query: 94  KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 152
           +++   P   P   L Q   + +  ++ + T  Q+      EY+ E    K   V ++A 
Sbjct: 741 EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 795

Query: 153 -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 206
            L+ +I + E   LK    ET+  E ++ L+    + +E   +L   +    S  ++A+ 
Sbjct: 796 ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 855

Query: 207 KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 265
           +++ +QT LE+T+  L   + +++E   A   +I+ +  +     QR    ++R  E LR
Sbjct: 856 RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 915


>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
          Length = 1253

 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 86/351 (24%), Positives = 149/351 (42%), Gaps = 49/351 (13%)

Query: 154 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 212
           +E +R   + L+ + ET+ L++ E K +    EK +   E      SK++E +  +Q   
Sbjct: 197 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 256

Query: 213 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 272
               K   E  + K +Y EE    AD IEM   D E A +RAE  Q+E E L+E++    
Sbjct: 257 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 316

Query: 273 HSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSAS- 331
             L++         +  E+  + S   + AA   ++ QL E   RL+ +L ++R+ S+S 
Sbjct: 317 TDLEI---------LKAEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSSSE 364

Query: 332 -----------------------QISQLEQQLSAKNSTLKQLEEKLKGQADYEEV----- 363
                                  Q  +L+++LS   ST+ +L+E++      EE+     
Sbjct: 365 KQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 424

Query: 364 KKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQ 423
            + LN+ + +     E  G  +A   +   L E  R  + E   LR        R  E Q
Sbjct: 425 DRNLNLEEKVR-ELRETVGDLEAMNEMNDELQENARETELE---LREQLDMAGARVREAQ 480

Query: 424 VRITEAVATATEQRELIARLEQDLSIIQSIQRP---DAEGAAEHRLEKIPE 471
            R+  A  T  + ++ I +  Q  + +Q + R      E + E + +  PE
Sbjct: 481 KRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 531



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 87/410 (21%), Positives = 173/410 (42%), Gaps = 43/410 (10%)

Query: 66  PLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQ---QLQLKVQRLHDI 122
           P+L S  G +  L   SKE E     V     D+ + +  L L +   + +LK    H I
Sbjct: 179 PVLTS-PGAVPPLPSPSKEEEGLRAQVR----DLEEKLETLRLKRAEDKAKLKELEKHKI 233

Query: 123 ETEN-----QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE- 176
           + E       K++E   +  +   E + +       KE+  E      +  E   L+KE 
Sbjct: 234 QLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEM 293

Query: 177 -----QKLQNDFAEKERKLQETQMSTTSKLEEAEHK-----VQSLQ-TALEKTRTELFDL 225
                + LQ +    + ++ E          E E K       S Q   LE+    L D 
Sbjct: 294 AEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDA 353

Query: 226 KTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKA 284
             +  + ++++  E   +   +E+ NQ  EV +++ E L+E+LS A  ++ +L  Q+  A
Sbjct: 354 LVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 413

Query: 285 --PDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSA 342
              +  +E+LT  +L +E   K RE+ + V D++ +     +L+EN+     +L +QL  
Sbjct: 414 LGAEEMVEMLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 471

Query: 343 KNSTLKQLEEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 397
             + +++ +++++      ADY++ +KK   +   ++    E    Q+A+       +E+
Sbjct: 472 AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS-------VER 524

Query: 398 NRSLQSENAALRISNSDLSGRCAELQVRITE-AVATATEQRELIARLEQD 446
            +    E    +I  ++       +++ + +  VA A     L+     D
Sbjct: 525 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPD 574



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 62/303 (20%), Positives = 125/303 (41%), Gaps = 32/303 (10%)

Query: 26  ATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ--GEIDALS---- 79
           A A  +A    E  + R   ++Q  E  K   ++L   +  L    +  G   A S    
Sbjct: 281 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL 340

Query: 80  KRSKEAEAAFLNVYKRLIDVP--DPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
           K+ +E  A   +   R+ D+   +    + L + ++ K Q L  +  + ++L+E L +  
Sbjct: 341 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE 400

Query: 138 KEFAEVKNQ-------EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKL 190
               E+K Q       E  ++ L ++    E+ ++   ET+   +     ND  E +   
Sbjct: 401 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMND--ELQENA 458

Query: 191 QETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER- 249
           +ET++    +L+ A  +V+  Q  +E  +  + D      ++T  K  ++   + D+ R 
Sbjct: 459 RETELELREQLDMAGARVREAQKRVEAAQETVADY-----QQTIKKYRQLTAHLQDVNRE 513

Query: 250 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREI 308
             NQ+    +R+     +Q        ++     KA   AIE+  R   ++E+A   R +
Sbjct: 514 LTNQQEASVERQ-----QQPPPETFDFKIKFAETKAHAKAIEMELR---QMEVAQANRHM 565

Query: 309 AQL 311
           + L
Sbjct: 566 SLL 568



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 13/180 (7%)

Query: 94   KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 152
            +++   P   P   L Q   + +  ++ + T  Q+      EY+ E    K   V ++A 
Sbjct: 855  EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 909

Query: 153  -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 206
             L+ +I + E   LK    ET+  E ++ L+    + +E   +L   +    S  ++A+ 
Sbjct: 910  ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 969

Query: 207  KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 265
            +++ +QT LE+T+  L   + +++E   A   +I+ +  +     QR    ++R  E LR
Sbjct: 970  RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029


>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
          Length = 1144

 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 86/351 (24%), Positives = 149/351 (42%), Gaps = 49/351 (13%)

Query: 154 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 212
           +E +R   + L+ + ET+ L++ E K +    EK +   E      SK++E +  +Q   
Sbjct: 83  EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142

Query: 213 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 272
               K   E  + K +Y EE    AD IEM   D E A +RAE  Q+E E L+E++    
Sbjct: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 202

Query: 273 HSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSAS- 331
             L++         +  E+  + S   + AA   ++ QL E   RL+ +L ++R+ S+S 
Sbjct: 203 TDLEI---------LKAEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSSSE 250

Query: 332 -----------------------QISQLEQQLSAKNSTLKQLEEKLKGQADYEEV----- 363
                                  Q  +L+++LS   ST+ +L+E++      EE+     
Sbjct: 251 KQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310

Query: 364 KKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQ 423
            + LN+ + +     E  G  +A   +   L E  R  + E   LR        R  E Q
Sbjct: 311 DRNLNLEEKVR-ELRETVGDLEAMNEMNDELQENARETELE---LREQLDMAGARVREAQ 366

Query: 424 VRITEAVATATEQRELIARLEQDLSIIQSIQRP---DAEGAAEHRLEKIPE 471
            R+  A  T  + ++ I +  Q  + +Q + R      E + E + +  PE
Sbjct: 367 KRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 417



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 87/410 (21%), Positives = 173/410 (42%), Gaps = 43/410 (10%)

Query: 66  PLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQ---QLQLKVQRLHDI 122
           P+L S  G +  L   SKE E     V     D+ + +  L L +   + +LK    H I
Sbjct: 65  PVLTS-PGAVPPLPSPSKEEEGLRAQVR----DLEEKLETLRLKRAEDKAKLKELEKHKI 119

Query: 123 ETEN-----QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE- 176
           + E       K++E   +  +   E + +       KE+  E      +  E   L+KE 
Sbjct: 120 QLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEM 179

Query: 177 -----QKLQNDFAEKERKLQETQMSTTSKLEEAEHK-----VQSLQ-TALEKTRTELFDL 225
                + LQ +    + ++ E          E E K       S Q   LE+    L D 
Sbjct: 180 AEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDA 239

Query: 226 KTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKA 284
             +  + ++++  E   +   +E+ NQ  EV +++ E L+E+LS A  ++ +L  Q+  A
Sbjct: 240 LVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 299

Query: 285 --PDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSA 342
              +  +E+LT  +L +E   K RE+ + V D++ +     +L+EN+     +L +QL  
Sbjct: 300 LGAEEMVEMLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 357

Query: 343 KNSTLKQLEEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 397
             + +++ +++++      ADY++ +KK   +   ++    E    Q+A+       +E+
Sbjct: 358 AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS-------VER 410

Query: 398 NRSLQSENAALRISNSDLSGRCAELQVRITE-AVATATEQRELIARLEQD 446
            +    E    +I  ++       +++ + +  VA A     L+     D
Sbjct: 411 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPD 460



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 62/303 (20%), Positives = 125/303 (41%), Gaps = 32/303 (10%)

Query: 26  ATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ--GEIDALS---- 79
           A A  +A    E  + R   ++Q  E  K   ++L   +  L    +  G   A S    
Sbjct: 167 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL 226

Query: 80  KRSKEAEAAFLNVYKRLIDVP--DPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
           K+ +E  A   +   R+ D+   +    + L + ++ K Q L  +  + ++L+E L +  
Sbjct: 227 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE 286

Query: 138 KEFAEVKNQ-------EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKL 190
               E+K Q       E  ++ L ++    E+ ++   ET+   +     ND  E +   
Sbjct: 287 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMND--ELQENA 344

Query: 191 QETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER- 249
           +ET++    +L+ A  +V+  Q  +E  +  + D      ++T  K  ++   + D+ R 
Sbjct: 345 RETELELREQLDMAGARVREAQKRVEAAQETVADY-----QQTIKKYRQLTAHLQDVNRE 399

Query: 250 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREI 308
             NQ+    +R+     +Q        ++     KA   AIE+  R   ++E+A   R +
Sbjct: 400 LTNQQEASVERQ-----QQPPPETFDFKIKFAETKAHAKAIEMELR---QMEVAQANRHM 451

Query: 309 AQL 311
           + L
Sbjct: 452 SLL 454



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 53/258 (20%), Positives = 116/258 (44%), Gaps = 16/258 (6%)

Query: 94  KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 152
           +++   P   P   L Q   + +  ++ + T  Q+      EY+ E    K   V ++A 
Sbjct: 741 EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 795

Query: 153 -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 206
            L+ +I + E   LK    ET+  E ++ L+    + +E   +L   +    S  ++A+ 
Sbjct: 796 ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 855

Query: 207 KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 265
           +++ +QT LE+T+  L   + +++E   A   +I+ +  +     QR    ++R  E LR
Sbjct: 856 RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 915

Query: 266 EQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKL 325
               S   +L      ++    AI      S+      K+  +  L++ +  ++  +++L
Sbjct: 916 GPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPL--LLQQISAMRLHISQL 973

Query: 326 R-ENSASQISQLEQQLSA 342
           + ENS  + +Q++  L++
Sbjct: 974 QHENSILKGAQMKASLAS 991


>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
          Length = 1278

 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 86/351 (24%), Positives = 149/351 (42%), Gaps = 49/351 (13%)

Query: 154 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 212
           +E +R   + L+ + ET+ L++ E K +    EK +   E      SK++E +  +Q   
Sbjct: 217 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 276

Query: 213 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 272
               K   E  + K +Y EE    AD IEM   D E A +RAE  Q+E E L+E++    
Sbjct: 277 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 336

Query: 273 HSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSAS- 331
             L++         +  E+  + S   + AA   ++ QL E   RL+ +L ++R+ S+S 
Sbjct: 337 TDLEI---------LKAEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSSSE 384

Query: 332 -----------------------QISQLEQQLSAKNSTLKQLEEKLKGQADYEEV----- 363
                                  Q  +L+++LS   ST+ +L+E++      EE+     
Sbjct: 385 KQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 444

Query: 364 KKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQ 423
            + LN+ + +     E  G  +A   +   L E  R  + E   LR        R  E Q
Sbjct: 445 DRNLNLEEKVR-ELRETVGDLEAMNEMNDELQENARETELE---LREQLDMAGARVREAQ 500

Query: 424 VRITEAVATATEQRELIARLEQDLSIIQSIQRP---DAEGAAEHRLEKIPE 471
            R+  A  T  + ++ I +  Q  + +Q + R      E + E + +  PE
Sbjct: 501 KRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 551



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 87/410 (21%), Positives = 173/410 (42%), Gaps = 43/410 (10%)

Query: 66  PLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQ---QLQLKVQRLHDI 122
           P+L S  G +  L   SKE E     V     D+ + +  L L +   + +LK    H I
Sbjct: 199 PVLTS-PGAVPPLPSPSKEEEGLRAQVR----DLEEKLETLRLKRAEDKAKLKELEKHKI 253

Query: 123 ETEN-----QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE- 176
           + E       K++E   +  +   E + +       KE+  E      +  E   L+KE 
Sbjct: 254 QLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEM 313

Query: 177 -----QKLQNDFAEKERKLQETQMSTTSKLEEAEHK-----VQSLQ-TALEKTRTELFDL 225
                + LQ +    + ++ E          E E K       S Q   LE+    L D 
Sbjct: 314 AEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDA 373

Query: 226 KTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKA 284
             +  + ++++  E   +   +E+ NQ  EV +++ E L+E+LS A  ++ +L  Q+  A
Sbjct: 374 LVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 433

Query: 285 --PDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSA 342
              +  +E+LT  +L +E   K RE+ + V D++ +     +L+EN+     +L +QL  
Sbjct: 434 LGAEEMVEMLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 491

Query: 343 KNSTLKQLEEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 397
             + +++ +++++      ADY++ +KK   +   ++    E    Q+A+       +E+
Sbjct: 492 AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS-------VER 544

Query: 398 NRSLQSENAALRISNSDLSGRCAELQVRITE-AVATATEQRELIARLEQD 446
            +    E    +I  ++       +++ + +  VA A     L+     D
Sbjct: 545 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPD 594



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 62/303 (20%), Positives = 125/303 (41%), Gaps = 32/303 (10%)

Query: 26  ATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ--GEIDALS---- 79
           A A  +A    E  + R   ++Q  E  K   ++L   +  L    +  G   A S    
Sbjct: 301 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL 360

Query: 80  KRSKEAEAAFLNVYKRLIDVP--DPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
           K+ +E  A   +   R+ D+   +    + L + ++ K Q L  +  + ++L+E L +  
Sbjct: 361 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE 420

Query: 138 KEFAEVKNQ-------EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKL 190
               E+K Q       E  ++ L ++    E+ ++   ET+   +     ND  E +   
Sbjct: 421 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMND--ELQENA 478

Query: 191 QETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER- 249
           +ET++    +L+ A  +V+  Q  +E  +  + D      ++T  K  ++   + D+ R 
Sbjct: 479 RETELELREQLDMAGARVREAQKRVEAAQETVADY-----QQTIKKYRQLTAHLQDVNRE 533

Query: 250 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREI 308
             NQ+    +R+     +Q        ++     KA   AIE+  R   ++E+A   R +
Sbjct: 534 LTNQQEASVERQ-----QQPPPETFDFKIKFAETKAHAKAIEMELR---QMEVAQANRHM 585

Query: 309 AQL 311
           + L
Sbjct: 586 SLL 588



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 53/258 (20%), Positives = 116/258 (44%), Gaps = 16/258 (6%)

Query: 94   KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 152
            +++   P   P   L Q   + +  ++ + T  Q+      EY+ E    K   V ++A 
Sbjct: 875  EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 929

Query: 153  -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 206
             L+ +I + E   LK    ET+  E ++ L+    + +E   +L   +    S  ++A+ 
Sbjct: 930  ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 989

Query: 207  KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 265
            +++ +QT LE+T+  L   + +++E   A   +I+ +  +     QR    ++R  E LR
Sbjct: 990  RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1049

Query: 266  EQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKL 325
                S   +L      ++    AI      S+      K+  +  L++ +  ++  +++L
Sbjct: 1050 GPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPL--LLQQISAMRLHISQL 1107

Query: 326  R-ENSASQISQLEQQLSA 342
            + ENS  + +Q++  L++
Sbjct: 1108 QHENSILKGAQMKASLAS 1125


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 115/547 (21%), Positives = 234/547 (42%), Gaps = 72/547 (13%)

Query: 13   KRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFK--KNTPEDLRKQVAPLLKS 70
            K+ +L ++  +LD     L ++Q+   Q    L E   ++   +   E+L  Q+  L   
Sbjct: 679  KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL--- 735

Query: 71   FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLR 130
               E D+L  ++ + +A      +R ++    + A +L +QL+++ + +     + QK  
Sbjct: 736  ---EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKS 792

Query: 131  ETLEEYNKEFAEVKNQEVTIK----ALKEKIREYEQTLKNQAET-------IALEKEQKL 179
            E LE   ++  + + ++  +K     L ++ +   + L N+ +T       + +EKE  +
Sbjct: 793  EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM 852

Query: 180  QNDFAEKER--KLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
                  K++  K+ ++  ++ S+ E+   K ++    LEKT  EL        E T  + 
Sbjct: 853  TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ 912

Query: 238  DEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSS- 296
             E++     LE+  + +   + E  +++EQL  A ++L+   + ++     I  L +SS 
Sbjct: 913  KELKK---SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969

Query: 297  ---LEVELAAKEREIA--QLVEDVQRLQASLTKLRENSASQ---ISQLEQQLSAKNSTLK 348
                ++E    E +IA  Q  E   +LQ  LT+  +  A++   IS L+        T K
Sbjct: 970  QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFK 1029

Query: 349  QLE--------EKLKGQADYEEVKKELNILKSMEFAPSEGAGTQD--------AAKPLEV 392
            QL+        E L  + D + V+++L++ +    +     G Q+        A   LE 
Sbjct: 1030 QLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ 1089

Query: 393  LLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQS 452
               +K + LQ    AL+    D+    +  +  +    +   E  E+  R E++++ +  
Sbjct: 1090 DSAKKEQQLQERCKALQ----DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLN- 1144

Query: 453  IQRPDAEGAAEHRLEKIPE--PIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERF 510
                  E    H+LE I E   +K+A  L             +G+ DSL + +  ++   
Sbjct: 1145 ------EELKSHKLESIKEITNLKDAKQLLIQQKLEL-----QGKADSLKAAVEQEK--- 1190

Query: 511  RARNQEL 517
              RNQ++
Sbjct: 1191 --RNQQI 1195



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 129/657 (19%), Positives = 268/657 (40%), Gaps = 117/657 (17%)

Query: 13  KRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ 72
           K  D QQLQ  L A+ T L     E        + +  E  +   E+L  +V    +  +
Sbjct: 342 KDLDCQQLQSRLSASETSLHRIHVE--------LSEKGEATQKLKEEL-SEVETKYQHLK 392

Query: 73  GEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD--IETENQ--K 128
            E   L ++ +E E                      G QLQ ++ +LH   +ETE Q  +
Sbjct: 393 AEFKQLQQQREEKEQH--------------------GLQLQSEINQLHSKLLETERQLGE 432

Query: 129 LRETLEEYNKEFAE-VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
               L+E  +  +E + ++E  +  L+ K+   E+ LK +  T + E + +L     ++ 
Sbjct: 433 AHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKV-TNSTELQHQLDKT-KQQH 490

Query: 188 RKLQETQMSTTSKLEEAEH--------------KVQSLQ----------TALEKTRTELF 223
           ++ Q  Q STT+KL EA++              K+Q+L+          + LEK R +L+
Sbjct: 491 QEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLY 550

Query: 224 DLKTKYDEETTAKADEI--------EMIMTDLERANQRAEVAQREAETLREQLSSANHSL 275
             K +  E  TA  +++        E +    E+   ++E  ++  E L +Q+      L
Sbjct: 551 -AKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHL 609

Query: 276 ---------------QLASQIQKAPDVA--IEVLTRSSLEVELAAKEREIAQLVEDVQRL 318
                          +L SQ+ ++ +    +++  ++  E+ L+A+  + AQ  +    L
Sbjct: 610 RAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHL 669

Query: 319 QASLTKLRENS------ASQISQLEQQLSAKNSTLKQLEEKLKG--------QADYEEVK 364
             +   L++         +Q+ Q+  +L  K     QLE  LK         +   EE++
Sbjct: 670 DTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELE 729

Query: 365 KELNILK--SMEFAPSEGAGTQDAAK------PLEVLLLEKNRSLQSENAALRISNSDLS 416
            ++  L+  S+E   S+    QD  +       LE+   E ++ L+ E   +  +  DL 
Sbjct: 730 GQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQ 789

Query: 417 GRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEA 476
            +   L+  I + +    E+++++ +  + LS    IQ  +     +  + ++ +   E 
Sbjct: 790 KKSEALE-SIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEK 848

Query: 477 TALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELD 536
            AL          +  + ++  +   + + +  F   NQ+ +A     + T + L+ +L 
Sbjct: 849 EALM------TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQ 902

Query: 537 SLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL 593
               + +K  +++K  +S       S   +L  +S  E+ +   ++  + E++ + L
Sbjct: 903 VQMENTLKEQKELK--KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL 957



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 118/557 (21%), Positives = 221/557 (39%), Gaps = 121/557 (21%)

Query: 100 PDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVT-IKALKEKIR 158
           P  + +L    +L    + +HD   ++    E+     ++   +  QEV  ++A  ++ +
Sbjct: 44  PQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEK 103

Query: 159 EYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ---MSTTSKLEEAEHK---VQSLQ 212
            Y + LK +     LEK Q LQ   A+ +  + ++     S   +LEEA+ +   ++ ++
Sbjct: 104 WYSEELKKE-----LEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMK 158

Query: 213 TALEKTR----TELFDLKTKYDEETTAK-----------------ADEIEMIMTDLERAN 251
              E+      TE+ D+K+KYDEE + +                 A  I+ + T+L +  
Sbjct: 159 DLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRP 218

Query: 252 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPD--------VAIEVLTRSSLEVELAA 303
              +VA  + E ++ Q    N +L+   + +K  D         A    T S L  ELA 
Sbjct: 219 GIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAK 278

Query: 304 KEREIAQLVEDVQRLQASLTKL-------------------------RENSASQ------ 332
             +E+A  V+++Q+L++S+ +L                          E S S+      
Sbjct: 279 GPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQAT 338

Query: 333 -------ISQLEQQLSAKNSTLKQLEEKL--KGQA-------------DYEEVKKELNIL 370
                    QL+ +LSA  ++L ++  +L  KG+A              Y+ +K E   L
Sbjct: 339 LHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQL 398

Query: 371 KSM-EFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISN--------------SDL 415
           +   E     G   Q     L   LLE  R L   +  L+                 +DL
Sbjct: 399 QQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADL 458

Query: 416 SGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAE--GAAEHRLEKIPEPI 473
             + + L+ ++ E V  +TE +  + + +Q     Q++Q+        A++ LE++   I
Sbjct: 459 QLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQI 518

Query: 474 KEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQS 533
            +         A    +         +S++  +RE   A+ Q  E E  +    L  LQ 
Sbjct: 519 GDKDQKIQNLEALLQKSKEN------ISLLEKEREDLYAKIQAGEGETAV----LNQLQE 568

Query: 534 ELDSLRADNIKLFEKIK 550
           +  +L+    +L EK+K
Sbjct: 569 KNHTLQEQVTQLTEKLK 585



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 66/334 (19%), Positives = 153/334 (45%), Gaps = 46/334 (13%)

Query: 14   RFDLQQLQRELD-ATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ 72
            R DL+ ++ +L  A   +++NR     Q++  LI++ +  K    +D  K+   L +  +
Sbjct: 1046 RQDLKSVEEKLSLAQEDLISNRNQIGNQNK--LIQELKTAKATLEQDSAKKEQQLQERCK 1103

Query: 73   GEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQ-------LKVQRLHDIETE 125
               D   ++S + E   +N   +L ++ +    +   Q+ +       LK  +L  I+ E
Sbjct: 1104 ALQDIQKEKSLK-EKELVNEKSKLAEIEE----IKCRQEKEITKLNEELKSHKLESIK-E 1157

Query: 126  NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAE 185
               L++  +   ++  E++ +  ++KA  E+ +  +Q LK+Q +    ++E++L+ +F E
Sbjct: 1158 ITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK----KEEEELKKEFIE 1213

Query: 186  KERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMT 245
            KE KL        S+++E E  ++  +           + + K   + TA  + +  +  
Sbjct: 1214 KEAKLH-------SEIKEKEVGMKKHE-----------ENEAKLTMQITALNENLGTVKK 1255

Query: 246  DLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRS-SLEVELAAK 304
            + + + +R    +++ + LR +++       L + +Q   D    +L R    E E+   
Sbjct: 1256 EWQSSQRRVSELEKQTDDLRGEIA------VLEATVQNNQDERRALLERCLKGEGEIEKL 1309

Query: 305  EREIAQLVEDVQRLQASLTKL-RENSASQISQLE 337
            + ++ +L   +    A++ +L REN + QI   +
Sbjct: 1310 QTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQ 1343



 Score = 37.0 bits (84), Expect = 0.060
 Identities = 54/271 (19%), Positives = 115/271 (42%), Gaps = 20/271 (7%)

Query: 331 SQISQLEQQLSAKNSTLKQLEEKLKGQADY-EEVKKELNILKSMEF--APSEGAGTQDAA 387
           S ++     ++     ++ L+  LK +  Y EE+KKEL   + ++   A  +G  T  +A
Sbjct: 76  SNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSA 135

Query: 388 KPLEVLLLEKN-RSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQD 446
              E+  LE+     Q+EN  ++        + A+L   I +  +   E+R L    EQ 
Sbjct: 136 ---ELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQK 192

Query: 447 LSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQ 506
           ++ +      +A    + + E +  P  E  A+               QV +L+  ++ +
Sbjct: 193 VTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELV---------QVQTLMDNMTLE 243

Query: 507 RERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIK-FLQSYPGRGSGSDDT 565
           RER    +++L+ E +  Q    + ++ +  LR++  K  +++  ++Q      S  ++ 
Sbjct: 244 RER---ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL 300

Query: 566 ELRYSSQYEERLDPFSSFSKRERQRKYLSLS 596
             +  +  E  L     ++K E +    S+S
Sbjct: 301 TQKNQTLTENLLKKEQDYTKLEEKHNEESVS 331


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 102/454 (22%), Positives = 200/454 (44%), Gaps = 53/454 (11%)

Query: 16   DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
            ++ +L+ + DA    L    +E+ ++ + L  +S     NT E  +      +K  Q E 
Sbjct: 777  EMDKLKEQYDAELQALRESVEEATKNVEVLASRS-----NTSEQDQAGTEMRVKLLQEEN 831

Query: 76   DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEE 135
            + L  RS+E E     + +++ D+         G + + K + L   E E ++L E L  
Sbjct: 832  EKLQGRSEELERRVAQLQRQIEDLK--------GDEAKAK-ETLKKYEGEIRQLEEALVH 882

Query: 136  YNKEFAEVKNQ----EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 191
              KE  E  +     E  ++A +  + +  Q  K  +E +  E EQK      E+ R+L+
Sbjct: 883  ARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQK------EQLRRLK 936

Query: 192  ETQMSTTSKLEEAEHKVQS-LQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERA 250
                +    L +   K+Q  +   +E +RT   +L+ + DE       E+  +   L+  
Sbjct: 937  NEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEK 996

Query: 251  NQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAI---EVL--TRSSLEVELAAKE 305
               AE ++  A  +++++      L+     Q+A D A+   ++L  T   LE EL AK 
Sbjct: 997  TLEAEKSRLTAMKMQDEMRLMEEELR---DYQRAQDEALTKRQLLEQTLKDLEYELEAKS 1053

Query: 306  -------REIAQLVEDVQRLQASLTKLRENS----------ASQISQLEQQLSAKNSTLK 348
                   R + Q+ + V +L+  L + R NS            Q+ QL  +L  + +  +
Sbjct: 1054 HLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQ 1113

Query: 349  QLE-EKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAA 407
             LE +K+  +   +++K  +  L+    +  EG   Q  A+  E  L ++  S + + A 
Sbjct: 1114 DLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAE--LEDRLESEERDRAN 1171

Query: 408  LRISNSDLSGRCAELQVRITEAVATATEQRELIA 441
            L++SN  L  +  EL +++ +   + T+Q++ ++
Sbjct: 1172 LQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLS 1205



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 113/528 (21%), Positives = 220/528 (41%), Gaps = 93/528 (17%)

Query: 103  VPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQ 162
            +   +L +QLQL+V+   +I+ E +++R  LEE   +  E   +  T   L++++ E E 
Sbjct: 621  IEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST---LQQRLEESEG 677

Query: 163  TLKNQAE---TIALEKEQ------KLQNDFAEKERKLQETQMSTTSK----LEEAEHKVQ 209
             L+   E    + +E+EQ       LQ+  +E   +L   + S   +    +EE     Q
Sbjct: 678  ELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQ 737

Query: 210  SLQTALEKTRTELFDLKTKYDEETTA-KADEIEMIMTDLERANQRAEVAQREAETLREQL 268
             LQ  L   + E  DL  K + E TA K    E + +  +  ++  E    E + LRE +
Sbjct: 738  DLQDLL-IAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESV 796

Query: 269  SSANHSLQL-------ASQIQKAPDVAIEVLTRSSLEVELAAK--EREIAQL---VED-- 314
              A  ++++       + Q Q   ++ +++L   + +++  ++  ER +AQL   +ED  
Sbjct: 797  EEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLK 856

Query: 315  ----------------VQRLQASLTKLRENSASQIS---QLEQQLSAKNSTL-------K 348
                            +++L+ +L   R+     +S    LE +L A    L       K
Sbjct: 857  GDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQK 916

Query: 349  QLEEKLKGQADYEEVKKEL---------NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNR 399
            QL EKLK +++ +E  + L         ++ K++E    E A   +A++   + L  +  
Sbjct: 917  QLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLD 976

Query: 400  SLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAE 459
              + +N              AE+Q ++ E    A + R    +++ ++ +++   R D +
Sbjct: 977  EYKEKNRR----------ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELR-DYQ 1025

Query: 460  GAAEHRLEKIPEPIKEATALFYGPAAPASGALPEG------QVDSLLSIISSQRERFRAR 513
             A +  L K    + E T         A   L +       Q++  +S +  + E  R  
Sbjct: 1026 RAQDEALTK--RQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNN 1083

Query: 514  NQELEAENRLAQHTLQALQSEL-------DSLRADNIKLFEKIKFLQS 554
            +  L      ++  ++ L++EL         L  D I L  + K L+S
Sbjct: 1084 SDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKS 1131



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 83/384 (21%), Positives = 175/384 (45%), Gaps = 58/384 (15%)

Query: 20   LQRELDATATVLANRQDESEQSRKRLIEQSREFK-----KNTPEDLRKQVAPLLKSFQGE 74
            L+ EL+A    L+    E +Q  ++L E+S + +     KN  E+ R  +   ++  Q E
Sbjct: 897  LENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKE 956

Query: 75   IDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQL-QLKVQRLHDIETENQKLRE-T 132
            +  + + S+ +                    L+L  QL + K +   ++    ++L+E T
Sbjct: 957  MADIVEASRTS-------------------TLELQNQLDEYKEKNRRELAEMQRQLKEKT 997

Query: 133  LEEYNKEFAEVKNQEVTIKALKEKIREY--------------EQTLKNQAETIALEKEQK 178
            LE        +K Q+  ++ ++E++R+Y              EQTLK+      LE +  
Sbjct: 998  LEAEKSRLTAMKMQD-EMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLE--YELEAKSH 1054

Query: 179  LQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKAD 238
            L++D +   +++++       +LEE  +    L   + ++R ++  L+ +  +E  A+ D
Sbjct: 1055 LKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQD 1114

Query: 239  EIEMIMTDLERANQ--RAEVAQREAETLREQLSSANHSLQLASQIQKAPD-VAIEVLTRS 295
             +E     LER N+  ++ +   E      + S     +Q+ ++I +  D +  E   R+
Sbjct: 1115 -LECDKISLERQNKDLKSRIIHLEGSY---RSSKEGLVVQMEARIAELEDRLESEERDRA 1170

Query: 296  SLEVELAAKEREIAQLVEDVQRLQASLTKLRENSA-------SQISQLEQQLSAKNSTLK 348
            +L++     ER++ +LV  V     SLT  ++  +        Q+ + E+++    S+ K
Sbjct: 1171 NLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKK 1230

Query: 349  QLEEKLKGQADY-EEVKKELNILK 371
            +L+ +L+ Q D  E ++ +LN +K
Sbjct: 1231 KLQRELEEQMDMNEHLQGQLNSMK 1254



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 130/651 (19%), Positives = 260/651 (39%), Gaps = 112/651 (17%)

Query: 16   DLQQLQRELDATATVLANRQDESEQSR---------------------KRLIEQSREFKK 54
            ++ +LQR+L        N ++E E+ R                     +RL E   E +K
Sbjct: 622  EVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRK 681

Query: 55   NTPEDL-----RKQVAPLLKSFQGEIDAL------SKRSKEAEAAFLNVYKRLIDVPDPV 103
            N  E       R+Q    ++  Q ++  +      +KRS++ E   L   + L+     +
Sbjct: 682  NLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGAL--IEELLQAKQDL 739

Query: 104  PALDLGQQLQLKVQRLHDIETENQK--LRETLEEYNKEFAEVKNQ-EVTIKALKEKIREY 160
              L + ++ Q  + R  + E    K  L+E +  +++E  ++K Q +  ++AL+E + E 
Sbjct: 740  QDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEA 799

Query: 161  EQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRT 220
             + ++  A      ++ +   +   + + LQE       + EE E +V  LQ  +E  + 
Sbjct: 800  TKNVEVLASRSNTSEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKG 857

Query: 221  ELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQ 280
            +    + K  E       EI  +   L  A +  + A      L  +L +A  +L   +Q
Sbjct: 858  D----EAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQ 913

Query: 281  IQKAPDVAI-------EVLTRSSLEVE---------LAAKEREIAQLVE----DVQRLQA 320
             QK     +       E L R   E+E         +   ++E+A +VE        LQ 
Sbjct: 914  EQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQN 973

Query: 321  SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEG 380
             L + +E +  +++++++QL  K  TL+  + +L      +E++     L+  + A    
Sbjct: 974  QLDEYKEKNRRELAEMQRQL--KEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRA---- 1027

Query: 381  AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQR--- 437
               QD A     LL +  + L+ E  A      D S    +++ ++++      E+R   
Sbjct: 1028 ---QDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNS 1084

Query: 438  ----ELIARLEQDLSIIQS------IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPA 487
                E I+R  + +  +++        R D E   +  LE+  + +K       G    +
Sbjct: 1085 DLLSERISRSREQMEQLRNELLQERAARQDLE-CDKISLERQNKDLKSRIIHLEGSYRSS 1143

Query: 488  SGALPEGQVDSLLSIISSQRERFRARNQE---LEAENRLAQHTLQALQSELD----SLRA 540
                 EG V  + + I+   +R  +  ++   L+  NR  +  ++ L  ++D    SL  
Sbjct: 1144 K----EGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD 1199

Query: 541  DNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRK 591
               +L  ++K ++              R   + EE +D   S SK++ QR+
Sbjct: 1200 QKDQLSLRLKAMK--------------RQVEEAEEEIDRLES-SKKKLQRE 1235


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 104/473 (21%), Positives = 216/473 (45%), Gaps = 55/473 (11%)

Query: 20   LQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTP-----EDLRKQVAPLLKSFQGE 74
            LQ ++ A +  L + ++  +Q  K   +   + K+ T      E++  ++    +  + E
Sbjct: 888  LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 947

Query: 75   IDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLE 134
               L K   + E     V K      + V   +L ++L    + +  +  E + L+E  +
Sbjct: 948  CSELKKDIDDLELTLAKVEKEKHATENKVK--NLTEELSGLDETIAKLTREKKALQEAHQ 1005

Query: 135  EYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ 194
            +   +    +++  ++   K K+ +  + L++     +LE+E+KL+ D    +RKL+   
Sbjct: 1006 QALDDLQAEEDKVNSLNKTKSKLEQQVEDLES-----SLEQEKKLRVDLERNKRKLEGDL 1060

Query: 195  MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETT------AKADEIEMIMTDLE 248
                  + + E+  Q L   L+K   E   L++K ++E T       K  E++  + +LE
Sbjct: 1061 KLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELE 1120

Query: 249  RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAK-ERE 307
               + AE A R A+T +++   A    +L+ ++++A  V       +S ++EL  K E E
Sbjct: 1121 EEIE-AERATR-AKTEKQRSDYARELEELSERLEEAGGV-------TSTQIELNKKREAE 1171

Query: 308  IAQLVEDVQRL----QASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEV 363
              +L  D++      +A +  LR+  A  +++L +Q+      L+++++KL  + +  E 
Sbjct: 1172 FLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQI----DNLQRVKQKL--EKEKSEF 1225

Query: 364  KKELNIL-KSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAEL 422
            K E++ L  SME      A  +   + LE  L E     + +N  ++ S S+L+ + + L
Sbjct: 1226 KLEIDDLSSSMESVSKSKANLEKICRTLEDQLSE----ARGKNEEIQRSLSELTTQKSRL 1281

Query: 423  QVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKE 475
            Q          TE  EL  +LE+  SI+  + R  ++ A   + E++   ++E
Sbjct: 1282 Q----------TEAGELSRQLEEKESIVSQLSR--SKQAFTQQTEELKRQLEE 1322



 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 114/582 (19%), Positives = 230/582 (39%), Gaps = 65/582 (11%)

Query: 14   RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
            R DL++   + +A    L  +  +S       I+  +  K+   ++  +        F+ 
Sbjct: 1176 RRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE--------FKL 1227

Query: 74   EIDALSKRSKEAEAAFLNVYKRLIDVPDPVP-ALDLGQQLQLKVQRLHDIETENQKLRET 132
            EID LS   +    +  N+ K    + D +  A    +++Q   + L ++ T+  +L+  
Sbjct: 1228 EIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQ---RSLSELTTQKSRLQTE 1284

Query: 133  LEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQE 192
              E +++  E ++    +   K+   +  + LK Q     LE+E K +N  A   +  + 
Sbjct: 1285 AGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ-----LEEENKAKNALAHALQSSRH 1339

Query: 193  TQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQ 252
                   + EE +     LQ AL K  +E+   +TKY+ +   + +E+E     L    Q
Sbjct: 1340 DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA---Q 1396

Query: 253  RAEVAQREAETLREQLSSANHSLQ-LASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQL 311
            R + ++ + E +  + +S   + Q L  +++   D+ ++V   +SL   L  K+R   ++
Sbjct: 1397 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVE---DLMVDVERANSLAAALDKKQRNFDKV 1453

Query: 312  V--------EDVQRLQASLTKLR---------------------------ENSASQISQL 336
            +        E    L+ASL + R                           +N   +I+ L
Sbjct: 1454 LAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADL 1513

Query: 337  EQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE 396
             +Q++    T+ +LE+  K Q + E+   +L + ++      E A        L  +  E
Sbjct: 1514 TEQIAENGKTIHELEKSRK-QIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSE 1572

Query: 397  KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 456
             +R +  ++  +     +       +Q  +   V +  E   L  ++E DL+ I+     
Sbjct: 1573 IDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSH 1632

Query: 457  DAEGAAE--HRLEKIPEPIKEATALFYGPAAPASGALPE--GQVDSLLSIISSQRERFRA 512
                AAE    L  +   +K+ T L    A      L E    V+   +++ ++ E  RA
Sbjct: 1633 ANRQAAETLKHLRSVQGQLKD-TQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRA 1691

Query: 513  RNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQS 554
              ++ E   +LA+  L      +  L   N  L    K L++
Sbjct: 1692 TLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLET 1733



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 97/498 (19%), Positives = 207/498 (41%), Gaps = 55/498 (11%)

Query: 119  LHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQK 178
            L   ETE + +    EE+ K   E+   E   K L+EK+     TL  +   + L+ + +
Sbjct: 841  LKSAETEKE-MATMKEEFQKTKDELAKSEAKRKELEEKL----VTLVQEKNDLQLQVQAE 895

Query: 179  LQN--DFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK 236
             +N  D  E+  +L + +    +K++E   + +      E+   EL   K K ++E +  
Sbjct: 896  SENLLDAEERCDQLIKAKFQLEAKIKEVTERAED----EEEINAELTAKKRKLEDECSEL 951

Query: 237  ADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQ----IQKAPDVAIEVL 292
              +I+ +   L +  +     + + + L E+LS  + ++   ++    +Q+A   A++ L
Sbjct: 952  KKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDL 1011

Query: 293  TRSSLEVELAAKER-EIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE 351
                 +V    K + ++ Q VED++       KLR +      +LE  L     ++  LE
Sbjct: 1012 QAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLE 1071

Query: 352  EKLKGQADYEEVKKEL---NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAA- 407
               K Q D    KK+     +   +E   + G   Q   K L+  + E    +++E A  
Sbjct: 1072 ND-KQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATR 1130

Query: 408  --LRISNSDLSGRCAELQVRITEAVATATEQREL-------IARLEQDL--------SII 450
                   SD +    EL  R+ EA    + Q EL         +L +DL        +++
Sbjct: 1131 AKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMV 1190

Query: 451  QSIQRPDAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGAL-----PEGQVDSLL 500
             ++++  A+  AE       L+++ + +++  + F       S ++      +  ++ + 
Sbjct: 1191 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKIC 1250

Query: 501  SIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGS 560
              +  Q    R +N+E+       Q +L  L ++   L+ +  +L  +++  +S   + S
Sbjct: 1251 RTLEDQLSEARGKNEEI-------QRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLS 1303

Query: 561  GSDDTELRYSSQYEERLD 578
             S     + + + + +L+
Sbjct: 1304 RSKQAFTQQTEELKRQLE 1321



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 57/254 (22%), Positives = 108/254 (42%), Gaps = 20/254 (7%)

Query: 16   DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
            ++++L+  L+ T       + E   S +R+  Q    +  +    +K++   L   Q E+
Sbjct: 1685 EVEELRATLEQTERARKLAEQELLDSNERV--QLLHTQNTSLIHTKKKLETDLMQLQSEV 1742

Query: 76   DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH-DIETENQKLRETLE 134
            +  S+ ++ AE       K + D       L   Q     ++R+  ++E   + L+  L+
Sbjct: 1743 EDASRDARNAEE---KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1799

Query: 135  EYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ 194
            E   E   +K  +  I+ L+ +IRE E           LE EQK   +  +  RK +   
Sbjct: 1800 E--AEQLALKGGKKQIQKLETRIRELE---------FELEGEQKKNTESVKGLRKYERRV 1848

Query: 195  MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKY---DEETTAKADEIEMIMTDLERAN 251
               T + EE    V  LQ  ++K + ++   K +    DE+  A   +      +LE A 
Sbjct: 1849 KELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAE 1908

Query: 252  QRAEVAQREAETLR 265
            +RA++A+ +   LR
Sbjct: 1909 ERADIAESQVNKLR 1922



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 89/380 (23%), Positives = 171/380 (45%), Gaps = 62/380 (16%)

Query: 18   QQLQREL-DATATVLANRQD--ESEQSRKRLIEQSREFKKNTPED---LRKQVAPLLK-- 69
            + L++E+ D T  +  N +   E E+SRK++  +  + +    E    L  + A +L+  
Sbjct: 1504 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ 1563

Query: 70   ----SFQGEIDA-LSKRSKEAEAAFLNVYKRLIDVPDPVPALDL-----GQQLQLKVQR- 118
                  + EID  ++++ +E E    N Y+R ++      ALD       + ++LK +  
Sbjct: 1564 LELTQVKSEIDRKIAEKDEEIEQLKRN-YQRTVETMQS--ALDAEVRSRNEAIRLKKKME 1620

Query: 119  --LHDIETE----NQKLRETLEEYNKEFAEVKNQEVTIK-ALK--EKIREYEQTLKNQAE 169
              L++IE +    N++  ETL+       ++K+ ++ +  AL+  E ++E    ++ +A 
Sbjct: 1621 GDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRAN 1680

Query: 170  TIALEKEQ-KLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTK 228
             +  E E+ +   +  E+ RKL E +      L ++  +VQ L T      T L   K K
Sbjct: 1681 LLQAEVEELRATLEQTERARKLAEQE------LLDSNERVQLLHTQ----NTSLIHTKKK 1730

Query: 229  YDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVA 288
             + +      E+E    D   A ++A+ A  +A  + E+L     +     +++K  +  
Sbjct: 1731 LETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1790

Query: 289  IEVLTRSSLEVE-LAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTL 347
            ++ L     E E LA K  +     + +Q+L+   T++RE        LE +L  +    
Sbjct: 1791 VKDLQHRLDEAEQLALKGGK-----KQIQKLE---TRIRE--------LEFELEGEQ--- 1831

Query: 348  KQLEEKLKGQADYEEVKKEL 367
            K+  E +KG   YE   KEL
Sbjct: 1832 KKNTESVKGLRKYERRVKEL 1851


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 110/588 (18%), Positives = 251/588 (42%), Gaps = 91/588 (15%)

Query: 58   EDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ 117
            E LR ++  ++K  +  ++A+  +  +AE       + L+++ D +  L   Q+ ++KV+
Sbjct: 647  EALRAKLMKVIKEKENSLEAIRSKLDKAED------QHLVEMEDTLNKL---QEAEIKVK 697

Query: 118  RLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQ 177
             L  ++ +  +  + ++ +  +          +KA +EK+ + +   K  +E  +  K+ 
Sbjct: 698  ELEVLQAKCNEQTKVIDNFTSQ----------LKATEEKLLDLDALRKASSEGKSEMKKL 747

Query: 178  KLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK- 236
            + Q + AEK+ K  E + +  S       K  S+   L+    +L +L+    E +  K 
Sbjct: 748  RQQLEAAEKQIKHLEIEKNAESS------KASSITRELQGRELKLTNLQENLSEVSQVKE 801

Query: 237  --ADEIEMIMTDLERANQRAEVAQRE-AETLREQLSSANHSLQLASQIQKAPDVAIEVLT 293
                E++++      A++ A   QR   ET+ +          L+S ++K  +       
Sbjct: 802  TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE------N 855

Query: 294  RSSLEVELAAKEREIAQLVEDVQRLQ---ASLTKLRENSASQISQLEQQLSAKNSTLKQL 350
             + +E +   K+    QL++  ++L+   A + K+  +++SQ++++  +L  K   +++L
Sbjct: 856  LADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEEL 915

Query: 351  EEKL-KGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALR 409
            + KL K   +   ++K +      +         Q+AAK  E    E+ + L+ + + L 
Sbjct: 916  QLKLTKANENASFLQKSIE-----DMTVKAEQSQQEAAKKHE----EEKKELERKLSDLE 966

Query: 410  ISNSDLSGRCAELQVRITEAVA-TATEQRELIARL---------------EQDLSIIQSI 453
                    +C EL+ R   A + T T+  E++  L               E++  ++Q +
Sbjct: 967  KKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL 1026

Query: 454  Q-------RPDAEGAAEHRLEKIPEPIKEAT-ALFYGPAAPASGALPEGQVDSL------ 499
            +       +  A   AE  ++ + +  KE T  L        + A  + ++D+L      
Sbjct: 1027 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK 1086

Query: 500  -LSIISSQRERFRARNQELEAENRLAQHTLQAL---QSELDSLRADNIKLFEKIKFLQSY 555
             +  ++  +E     NQ++E   +  +   QA      +L +L+ +N+KL E++      
Sbjct: 1087 NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL------ 1140

Query: 556  PGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATL 603
               G   D+       + E  +        ++R+ K++  +  +KA+L
Sbjct: 1141 ---GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASL 1185



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 115/586 (19%), Positives = 246/586 (41%), Gaps = 93/586 (15%)

Query: 16   DLQQLQRELDATATVLANRQDE--SEQSRKRLIE---QSREFKKNTPEDLRKQVAPLLKS 70
            ++++L+++L+A    + + + E  +E S+   I    Q RE K    ++   +V+ + ++
Sbjct: 743  EMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET 802

Query: 71   FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLR 130
             + E+  L ++  EA    ++V + + +  +         +L  K ++ + + ++ +KLR
Sbjct: 803  LEKELQILKEKFAEASEEAVSVQRSMQETVN---------KLHQKEEQFNMLSSDLEKLR 853

Query: 131  ETLEEYNKEFAEVKNQEVTIKALKEKIR-EYEQTLKNQAETIALEKEQKLQNDFAEKERK 189
            E L +   +F E   +E  +   KEK+  +  + +K   +  +  +  K+ ++   KER 
Sbjct: 854  ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS--QLTKMNDELRLKERD 911

Query: 190  LQETQMSTTSKLEEA--------------------------------EHKVQSLQTALEK 217
            ++E Q+  T   E A                                E K+  L+  +E 
Sbjct: 912  VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMET 971

Query: 218  TRTELFDLKTKYDEETTAKADEIEMIMTDLER----ANQRAEVAQREAETLREQLSSANH 273
            +  +  +LK +Y+  T+    + E I+ +L++       + + A+ E   L ++L     
Sbjct: 972  SHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK 1031

Query: 274  SLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQ---RLQASLTKLRENSA 330
                A   Q A D A++++ + + E     K   +A L +  Q   +LQ  L  L+EN+ 
Sbjct: 1032 QADKAKAAQTAED-AMQIMEQMTKE-----KTETLASLEDTKQTNAKLQNELDTLKENNL 1085

Query: 331  SQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPL 390
              + +L      K+  L  +E +       EE +KE+  LK      S+           
Sbjct: 1086 KNVEELN-----KSKELLTVENQ-----KMEEFRKEIETLKQAAAQKSQQLSALQEENVK 1135

Query: 391  EVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSII 450
                L ++R   + +  L    S L+ +  E++ R ++ +  A E++   A L++ +SI 
Sbjct: 1136 LAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK---ASLQKSISIT 1192

Query: 451  QS-IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRER 509
             + +   DAE      LEK    ++    +  G  A A        + S++  + S + +
Sbjct: 1193 SALLTEKDAE------LEK----LRNEVTVLRGENASAK------SLHSVVQTLESDKVK 1236

Query: 510  FRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFE-KIKFLQS 554
               + + LE + +  +  L +     D+   ++ +  E +I FL S
Sbjct: 1237 LELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNS 1282



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 121/582 (20%), Positives = 228/582 (39%), Gaps = 101/582 (17%)

Query: 38  SEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA-------LSKRSKEAEAAFL 90
           SE+SR   +E+    +     +LR+++     +  G++D        +S   ++ E    
Sbjct: 461 SEKSRIMELEKDLALRVQEVAELRRRLESNKPA--GDVDMSLSLLQEISSLQEKLEVTRT 518

Query: 91  NVYKRLIDVPDPVPALDLGQQLQLKV--QRLHDIETENQKLRETLEEYNKEFAEVKNQEV 148
           +  + +  + +   A +   Q ++K        +  EN+ L+  LE  NKE ++V     
Sbjct: 519 DHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDV----- 573

Query: 149 TIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKV 208
                                 IAL K  KL+   A  ++ ++E ++S +  L     + 
Sbjct: 574 ----------------------IALWK-SKLETAIASHQQAMEELKVSFSKGLGTETAEF 610

Query: 209 QSLQTALEKTRT----ELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETL 264
             L+T +EK R     E+ +L+ + D E  A A E+E +   L +  +  E      E +
Sbjct: 611 AELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE---NSLEAI 667

Query: 265 REQLSSA--NHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASL 322
           R +L  A   H +++   + K  +  I+V     LEV L AK  E  +++++      S 
Sbjct: 668 RSKLDKAEDQHLVEMEDTLNKLQEAEIKV---KELEV-LQAKCNEQTKVIDNF----TSQ 719

Query: 323 TKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAG 382
            K  E     +  L +  S   S +K+L ++L+     E+  K L I K+ E + +    
Sbjct: 720 LKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA---EKQIKHLEIEKNAESSKASSIT 776

Query: 383 TQDAAKPLEVLLLEKNRS--------LQSENAALRISNSDLSGRCAELQVRITEAVATAT 434
            +   + L++  L++N S        L+ E   L+   ++ S     +Q  + E V    
Sbjct: 777 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH 836

Query: 435 EQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEG 494
           ++ E    L  DL  ++     D E     + E+  + IK    L             E 
Sbjct: 837 QKEEQFNMLSSDLEKLRE-NLADMEAKFREKDEREEQLIKAKEKL-------------EN 882

Query: 495 QVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ- 553
            +  ++ +      +    N EL    RL +  ++ LQ +L        K  E   FLQ 
Sbjct: 883 DIAEIMKMSGDNSSQLTKMNDEL----RLKERDVEELQLKL-------TKANENASFLQK 931

Query: 554 SYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSL 595
           S       ++ ++   + ++EE         K+E +RK   L
Sbjct: 932 SIEDMTVKAEQSQQEAAKKHEE--------EKKELERKLSDL 965



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 96/461 (20%), Positives = 182/461 (39%), Gaps = 67/461 (14%)

Query: 129 LRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTL-----------KNQAETIALEKEQ 177
           L ET   Y ++   +       +ALKEK +  EQ L           K  +    +E+E 
Sbjct: 336 LTETSSRYARK---ISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQEL 392

Query: 178 KLQNDFAEKERKLQETQMSTT-SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK 236
            L  D  ++     E +M    + +E A+ +   L   LE+ + ++ DL+ + +EE+  K
Sbjct: 393 ALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITK 452

Query: 237 AD-EIEMIMTDLERANQRAEVAQR--EAETLREQLSSANHSLQLASQIQKAPDVAIEVLT 293
            D E+  +           ++A R  E   LR +L S   +  +   +    +++     
Sbjct: 453 GDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEIS---SL 509

Query: 294 RSSLEVELAAKEREIAQLVE-----------DVQRLQASLTKLRENSASQISQLEQQLSA 342
           +  LEV     +REI  L E           +++ L  +  KL + + S  S+LE     
Sbjct: 510 QEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKE 569

Query: 343 KNSTLKQLEEKLK-GQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSL 401
            +  +   + KL+   A +++  +EL +      + S+G GT+ A        +EK R L
Sbjct: 570 NSDVIALWKSKLETAIASHQQAMEELKV------SFSKGLGTETAEFAELKTQIEKMR-L 622

Query: 402 QSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQS-IQRPDAEG 460
             ++    + N   S R A  +    E  A   +  ++I   E  L  I+S + + + + 
Sbjct: 623 DYQHEIENLQNQQDSERAAHAK----EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH 678

Query: 461 AAE-----HRLEKIPEPIKEATAL-------------FYGPAAPASGALPEGQVDSLLSI 502
             E     ++L++    +KE   L             F          L +  +D+L   
Sbjct: 679 LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLD--LDALRKA 736

Query: 503 ISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNI 543
            S  +   +   Q+LEA  +  +H    ++   +S +A +I
Sbjct: 737 SSEGKSEMKKLRQQLEAAEKQIKHL--EIEKNAESSKASSI 775


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.126    0.333 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,163,020
Number of Sequences: 37866
Number of extensions: 903525
Number of successful extensions: 12459
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 342
Number of HSP's successfully gapped in prelim test: 1228
Number of HSP's that attempted gapping in prelim test: 5199
Number of HSP's gapped (non-prelim): 4494
length of query: 676
length of database: 18,247,518
effective HSP length: 109
effective length of query: 567
effective length of database: 14,120,124
effective search space: 8006110308
effective search space used: 8006110308
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.