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Search of human proteins with 31542634
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31542634 filamin A interacting protein 1 [Homo sapiens]
(1213 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 2344 0.0
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 934 0.0
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 934 0.0
gi|109659849 filamin A interacting protein 1-like isoform 2 [Hom... 741 0.0
gi|216548091 leucine zipper protein 1 [Homo sapiens] 322 1e-87
gi|216548085 leucine zipper protein 1 [Homo sapiens] 322 1e-87
gi|24308179 CTTNBP2 N-terminal like [Homo sapiens] 151 4e-36
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 137 6e-32
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 137 6e-32
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 137 6e-32
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 137 6e-32
gi|71061468 centromere protein E [Homo sapiens] 133 9e-31
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 132 3e-30
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 130 6e-30
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 127 5e-29
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 126 1e-28
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 126 1e-28
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 125 2e-28
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 124 5e-28
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 124 7e-28
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 123 1e-27
gi|221219020 NYD-SP11 protein [Homo sapiens] 122 2e-27
gi|148746195 trichohyalin [Homo sapiens] 122 2e-27
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 121 4e-27
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 121 5e-27
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 120 1e-26
gi|156104908 myosin heavy chain 6 [Homo sapiens] 119 1e-26
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 119 2e-26
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 119 2e-26
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 118 4e-26
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 2344 bits (6075), Expect = 0.0
Identities = 1213/1213 (100%), Positives = 1213/1213 (100%)
Query: 1 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLK 60
MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLK
Sbjct: 1 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLK 60
Query: 61 TSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEP 120
TSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEP
Sbjct: 61 TSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEP 120
Query: 121 EKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTV 180
EKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTV
Sbjct: 121 EKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTV 180
Query: 181 YELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDEL 240
YELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDEL
Sbjct: 181 YELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDEL 240
Query: 241 VKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLE 300
VKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLE
Sbjct: 241 VKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLE 300
Query: 301 VDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQ 360
VDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQ
Sbjct: 301 VDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQ 360
Query: 361 ELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKE 420
ELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKE
Sbjct: 361 ELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKE 420
Query: 421 LRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKEL 480
LRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKEL
Sbjct: 421 LRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKEL 480
Query: 481 ECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKV 540
ECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKV
Sbjct: 481 ECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKV 540
Query: 541 MDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRL 600
MDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRL
Sbjct: 541 MDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRL 600
Query: 601 DGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEY 660
DGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEY
Sbjct: 601 DGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEY 660
Query: 661 DQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL 720
DQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL
Sbjct: 661 DQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL 720
Query: 721 KAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSK 780
KAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSK
Sbjct: 721 KAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSK 780
Query: 781 RYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQ 840
RYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQ
Sbjct: 781 RYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQ 840
Query: 841 VGLKKPVERSSVLDRYPPAANELTMRKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEV 900
VGLKKPVERSSVLDRYPPAANELTMRKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEV
Sbjct: 841 VGLKKPVERSSVLDRYPPAANELTMRKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEV 900
Query: 901 VLSPKQGQPLHIRVTPDHENSTATLEITSPTSEEFFSSTTVIPTLGNQKPRITIIPSPNV 960
VLSPKQGQPLHIRVTPDHENSTATLEITSPTSEEFFSSTTVIPTLGNQKPRITIIPSPNV
Sbjct: 901 VLSPKQGQPLHIRVTPDHENSTATLEITSPTSEEFFSSTTVIPTLGNQKPRITIIPSPNV 960
Query: 961 MPQKQKSGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAE 1020
MPQKQKSGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAE
Sbjct: 961 MPQKQKSGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAE 1020
Query: 1021 IAVSPESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPG 1080
IAVSPESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPG
Sbjct: 1021 IAVSPESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPG 1080
Query: 1081 TSGEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSAR 1140
TSGEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSAR
Sbjct: 1081 TSGEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSAR 1140
Query: 1141 GTQSVSGQDGSSQRPTPTRIPMSKGMKAGKPVVAAPGAGNLTKFEPRAETQSMKIELKKS 1200
GTQSVSGQDGSSQRPTPTRIPMSKGMKAGKPVVAAPGAGNLTKFEPRAETQSMKIELKKS
Sbjct: 1141 GTQSVSGQDGSSQRPTPTRIPMSKGMKAGKPVVAAPGAGNLTKFEPRAETQSMKIELKKS 1200
Query: 1201 AASSTTSLGGGKG 1213
AASSTTSLGGGKG
Sbjct: 1201 AASSTTSLGGGKG 1213
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 934 bits (2413), Expect = 0.0
Identities = 518/1078 (48%), Positives = 727/1078 (67%), Gaps = 26/1078 (2%)
Query: 74 ELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAIL 133
+LS++DL+ LLSI+EGELQAR++VI +LK EK +LEA YG P+KVL L RDA
Sbjct: 66 DLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQ 125
Query: 134 AQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDY 193
A+ ED+YEKP++ELD++ EK KE+YRR+L QLL+AEK R+T+ ELE EK KH +Y
Sbjct: 126 AKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEY 185
Query: 194 MNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDE 253
M KSD+F LLEQE ERLKKL++QE Q KE+E KR+ L++EL KLKSFALM+VDE
Sbjct: 186 MEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDE 245
Query: 254 RQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQE 313
+Q QL LQ QK+Q+LT +E KL ++ +E+ QK +LE + + + ++F Q+
Sbjct: 246 QQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQD 305
Query: 314 HEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGN 373
+ + AKL N++S NRQL+ KL L+++I+ELEETN++L+KAEEELQ++++KI+KGE GN
Sbjct: 306 QDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGN 365
Query: 374 SSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMS 433
+ +MAEVE LRKRVL+MEGKDEE+ K E QCR+L K+L+ E SK+ +LEVEKL KR+
Sbjct: 366 AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIM 425
Query: 434 ELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELS 493
LEKLE+AF+KSK EC L NLEKE+ TK L ELE +K R+KELE ESRLEK E +
Sbjct: 426 ALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFT 485
Query: 494 LKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKK 553
LK+DLTKLK+ TVM VDERK M EK+K+ E K+ + +VEQ KV VTEKLIEE+K+
Sbjct: 486 LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKR 545
Query: 554 LLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRG 613
LK K+++EEK+Y++T+ERD+L KLK+EEEK ++L V++LK RL +E +E++ +
Sbjct: 546 ALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKN 605
Query: 614 R----SRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRT 669
+ S K + E+NKIKEL+ E+ERLK +L+ ++ +E DLMKTEDEY+ LE+++
Sbjct: 606 KLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
Query: 670 EQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKE 729
E+DKA FLS++LE +K ++AK K EK E S E L R + EEAKS L EV ALKE
Sbjct: 666 ERDKAQFLSKELEHVKMELAKYKLAEKTE-TSHEQWLFKRLQEEEAKSGHLSREVDALKE 724
Query: 730 KIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPS 789
KIHE M ED + LQ D+SVLQ++ ++EN+N+++G+E+ NLTKELE + +S++LRPS
Sbjct: 725 KIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPS 784
Query: 790 VNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVER 849
+NGRR+ D V S VQT+AV E + ++ R + + S + + P +
Sbjct: 785 LNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQD---EDPNDE 841
Query: 850 SSVLDRYPPAANELTM-RKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEVVLSPKQGQ 908
SVL + + RK WIPWM+ +E G + + N++ PG++VLS GQ
Sbjct: 842 GSVLSFKCSQSTPCPVNRKLWIPWMKSKE-GHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900
Query: 909 PLHIRVTPDHENSTATLEITSPTSE--EFFSSTTVIPTLGNQKPRITIIPSPNVMPQKQK 966
PLHI+VTPDH +TATLEITSPT+E ++ST VIP G K RITI+ + ++ P K K
Sbjct: 901 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960
Query: 967 -SGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAEIAVSP 1025
S + + E+ MSP+T+ TF+R +TPES +R SPIQ++ V+ SA+ E SP
Sbjct: 961 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020
Query: 1026 ESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPGTSGEG 1085
E E+ I +V+P++Q+ R ++++++ITTEDNKIHIHLGS + ++ +
Sbjct: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASP--- 1077
Query: 1086 VSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSARGTQ 1143
V P P+ + + G + ++ +KVTS+ITITP T R +Q
Sbjct: 1078 VRPASPSAPLQDNRTQGLINGALNKT----------TNKVTSSITITPTATPLPRQSQ 1125
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 934 bits (2413), Expect = 0.0
Identities = 518/1078 (48%), Positives = 727/1078 (67%), Gaps = 26/1078 (2%)
Query: 74 ELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAIL 133
+LS++DL+ LLSI+EGELQAR++VI +LK EK +LEA YG P+KVL L RDA
Sbjct: 66 DLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQ 125
Query: 134 AQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDY 193
A+ ED+YEKP++ELD++ EK KE+YRR+L QLL+AEK R+T+ ELE EK KH +Y
Sbjct: 126 AKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEY 185
Query: 194 MNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDE 253
M KSD+F LLEQE ERLKKL++QE Q KE+E KR+ L++EL KLKSFALM+VDE
Sbjct: 186 MEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDE 245
Query: 254 RQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQE 313
+Q QL LQ QK+Q+LT +E KL ++ +E+ QK +LE + + + ++F Q+
Sbjct: 246 QQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQD 305
Query: 314 HEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGN 373
+ + AKL N++S NRQL+ KL L+++I+ELEETN++L+KAEEELQ++++KI+KGE GN
Sbjct: 306 QDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGN 365
Query: 374 SSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMS 433
+ +MAEVE LRKRVL+MEGKDEE+ K E QCR+L K+L+ E SK+ +LEVEKL KR+
Sbjct: 366 AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIM 425
Query: 434 ELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELS 493
LEKLE+AF+KSK EC L NLEKE+ TK L ELE +K R+KELE ESRLEK E +
Sbjct: 426 ALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFT 485
Query: 494 LKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKK 553
LK+DLTKLK+ TVM VDERK M EK+K+ E K+ + +VEQ KV VTEKLIEE+K+
Sbjct: 486 LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKR 545
Query: 554 LLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRG 613
LK K+++EEK+Y++T+ERD+L KLK+EEEK ++L V++LK RL +E +E++ +
Sbjct: 546 ALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKN 605
Query: 614 R----SRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRT 669
+ S K + E+NKIKEL+ E+ERLK +L+ ++ +E DLMKTEDEY+ LE+++
Sbjct: 606 KLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
Query: 670 EQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKE 729
E+DKA FLS++LE +K ++AK K EK E S E L R + EEAKS L EV ALKE
Sbjct: 666 ERDKAQFLSKELEHVKMELAKYKLAEKTE-TSHEQWLFKRLQEEEAKSGHLSREVDALKE 724
Query: 730 KIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPS 789
KIHE M ED + LQ D+SVLQ++ ++EN+N+++G+E+ NLTKELE + +S++LRPS
Sbjct: 725 KIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPS 784
Query: 790 VNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVER 849
+NGRR+ D V S VQT+AV E + ++ R + + S + + P +
Sbjct: 785 LNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQD---EDPNDE 841
Query: 850 SSVLDRYPPAANELTM-RKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEVVLSPKQGQ 908
SVL + + RK WIPWM+ +E G + + N++ PG++VLS GQ
Sbjct: 842 GSVLSFKCSQSTPCPVNRKLWIPWMKSKE-GHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900
Query: 909 PLHIRVTPDHENSTATLEITSPTSE--EFFSSTTVIPTLGNQKPRITIIPSPNVMPQKQK 966
PLHI+VTPDH +TATLEITSPT+E ++ST VIP G K RITI+ + ++ P K K
Sbjct: 901 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960
Query: 967 -SGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAEIAVSP 1025
S + + E+ MSP+T+ TF+R +TPES +R SPIQ++ V+ SA+ E SP
Sbjct: 961 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020
Query: 1026 ESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPGTSGEG 1085
E E+ I +V+P++Q+ R ++++++ITTEDNKIHIHLGS + ++ +
Sbjct: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASP--- 1077
Query: 1086 VSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSARGTQ 1143
V P P+ + + G + ++ +KVTS+ITITP T R +Q
Sbjct: 1078 VRPASPSAPLQDNRTQGLINGALNKT----------TNKVTSSITITPTATPLPRQSQ 1125
>gi|109659849 filamin A interacting protein 1-like isoform 2 [Homo
sapiens]
Length = 893
Score = 741 bits (1914), Expect = 0.0
Identities = 416/903 (46%), Positives = 596/903 (66%), Gaps = 26/903 (2%)
Query: 249 MLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKAS 308
M+VDE+Q QL LQ QK+Q+LT +E KL ++ +E+ QK +LE + + + +
Sbjct: 1 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60
Query: 309 RFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAK 368
+F Q+ + + AKL N++S NRQL+ KL L+++I+ELEETN++L+KAEEELQ++++KI+K
Sbjct: 61 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 120
Query: 369 GECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKL 428
GE GN+ +MAEVE LRKRVL+MEGKDEE+ K E QCR+L K+L+ E SK+ +LEVEKL
Sbjct: 121 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 180
Query: 429 QKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLE 488
KR+ LEKLE+AF+KSK EC L NLEKE+ TK L ELE +K R+KELE ESRLE
Sbjct: 181 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 240
Query: 489 KAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLI 548
K E +LK+DLTKLK+ TVM VDERK M EK+K+ E K+ + +VEQ KV VTEKLI
Sbjct: 241 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 300
Query: 549 EESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVER 608
EE+K+ LK K+++EEK+Y++T+ERD+L KLK+EEEK ++L V++LK RL +E +E+
Sbjct: 301 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 360
Query: 609 EITRGR----SRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLE 664
+ + + S K + E+NKIKEL+ E+ERLK +L+ ++ +E DLMKTEDEY+ LE
Sbjct: 361 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 420
Query: 665 QKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEV 724
+++ E+DKA FLS++LE +K ++AK K EK E S E L R + EEAKS L EV
Sbjct: 421 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTE-TSHEQWLFKRLQEEEAKSGHLSREV 479
Query: 725 QALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSR 784
ALKEKIHE M ED + LQ D+SVLQ++ ++EN+N+++G+E+ NLTKELE + +S+
Sbjct: 480 DALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSK 539
Query: 785 ALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLK 844
+LRPS+NGRR+ D V S VQT+AV E + ++ R + + S + +
Sbjct: 540 SLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQD---E 596
Query: 845 KPVERSSVLDRYPPAANELTM-RKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEVVLS 903
P + SVL + + RK WIPWM+ +E G + + N++ PG++VLS
Sbjct: 597 DPNDEGSVLSFKCSQSTPCPVNRKLWIPWMKSKE-GHLQNGKMQTKPNANFVQPGDLVLS 655
Query: 904 PKQGQPLHIRVTPDHENSTATLEITSPTSE--EFFSSTTVIPTLGNQKPRITIIPSPNVM 961
GQPLHI+VTPDH +TATLEITSPT+E ++ST VIP G K RITI+ + ++
Sbjct: 656 HTPGQPLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASIT 715
Query: 962 PQKQK-SGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAE 1020
P K K S + + E+ MSP+T+ TF+R +TPES +R SPIQ++ V+ SA+ E
Sbjct: 716 PVKSKTSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPE 775
Query: 1021 IAVSPESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPG 1080
SPE E+ I +V+P++Q+ R ++++++ITTEDNKIHIHLGS + ++
Sbjct: 776 QGRSPEPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVA 835
Query: 1081 TSGEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSAR 1140
+ V P P+ + + G + ++ +KVTS+ITITP T R
Sbjct: 836 SP---VRPASPSAPLQDNRTQGLINGALNKT----------TNKVTSSITITPTATPLPR 882
Query: 1141 GTQ 1143
+Q
Sbjct: 883 QSQ 885
Score = 112 bits (279), Expect = 3e-24
Identities = 115/473 (24%), Positives = 218/473 (46%), Gaps = 47/473 (9%)
Query: 37 KKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQARED 96
++++K+ R E ++ T K H + T + + L Q L+ + ++ E+
Sbjct: 43 EEEQKATRLEKELQTQ-TTKFHQDQDTIMAKLTNEDSQ--NRQLQQKLAALSRQIDELEE 99
Query: 97 VIHMLKT-----EKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISEL 151
L+ + K ++ + YG+A + L R +L E G+D EL
Sbjct: 100 TNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL-RKRVLDME---GKD------EEL 149
Query: 152 DRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEK-HKHTDYMNKSDDFTNLLEQERER 210
++EE+ ++ +R+ + L ++ ++LE EK K + K +D N +QE
Sbjct: 150 IKMEEQCRDLNKRLERETLQSKD------FKLEVEKLSKRIMALEKLEDAFNKSKQECYS 203
Query: 211 LKKLLEQEK--AYQARKEKENAK-----------RLNK----LRDELVKLKSFALMLVDE 253
LK LE+E+ Q +E E+ K RL K L+++L KLK+ +M VDE
Sbjct: 204 LKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDE 263
Query: 254 RQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQE 313
R+ E+L K+Q + +L+ E+ K+ +T K E+ ++ LK + D E K ++E
Sbjct: 264 RKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKE 323
Query: 314 HEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGN 373
+++ KL +E L ++ L R++ LE K+ K + + A + N
Sbjct: 324 RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENN 383
Query: 374 --SSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKR 431
L EVE L+ ++ +M+ ++++ KTE + L ++ E ++ L E+E ++
Sbjct: 384 KIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVK-- 441
Query: 432 MSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSE 484
EL K + A S L L++E+ + L E++ +K ++ E +E
Sbjct: 442 -MELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATE 493
>gi|216548091 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 322 bits (826), Expect = 1e-87
Identities = 224/582 (38%), Positives = 320/582 (54%), Gaps = 68/582 (11%)
Query: 324 QESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENL 383
+ + +R LR KL L++R++ELEE KNLQKAE+EL +L+DK+ + E NSS++AE+E L
Sbjct: 9 ETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVL 68
Query: 384 RKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFS 443
R+RVL +EGKDEEI + E CR +++KL+EEE+ ++EL+ E+E+LQKRM+ELEKLEEAFS
Sbjct: 69 RQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFS 128
Query: 444 KSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKS 503
+SK++CTQL L+L +E+NLTK + +ELE+++ +VKELE SE RL+K E SL +L KLKS
Sbjct: 129 RSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKS 188
Query: 504 FTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEE 563
T+ V ERK + EK K+ E+ + L + K+EQ K K+ +
Sbjct: 189 LTLSFVSERKYLNEKEKENEKLIKELTQ--KLEQNK----------------KMNRDYTR 230
Query: 564 KVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTC 623
NL R L+ E+ SS L K LD +++VE E TR +S
Sbjct: 231 NASNLERN------DLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNKSENEKNRN- 282
Query: 624 PEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEE 683
EDNK+K+L EIE+LK +++ E +E +L K + + + L+ + +EQ+K L+ QLEE
Sbjct: 283 QEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEE 342
Query: 684 IKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQ 743
IK QI K K +E GEV ++A L + R E K R +E K EL + +
Sbjct: 343 IKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKR--- 399
Query: 744 LQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTST 803
L+ R N+N ++ ++ PS RR +
Sbjct: 400 -----ERLRNREFALNNENYSLSNRQVS---------------SPSFTNRRA--AKASHM 437
Query: 804 GVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERSSVLDRYPPAANEL 863
GV TD SG ++T F+ S Q E KK E+ SVL RYPPAA E
Sbjct: 438 GVSTD--SGTQETKKTEDRFVPGSSQSEG-----------KKSREQPSVLSRYPPAAQEH 484
Query: 864 TMRKSWIPWMRK-RENGPSITQEKGPRTNSSPGHPGEVVLSP 904
+ K+W + E+G EK RT S H G V P
Sbjct: 485 S--KAWKGTSKPGTESGLKGKVEKTTRTFSDTTH-GSVPSDP 523
Score = 82.8 bits (203), Expect = 2e-15
Identities = 87/371 (23%), Positives = 174/371 (46%), Gaps = 44/371 (11%)
Query: 199 DFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLK--------SFALML 250
+FT+ E R + Q + + + +E K L K DEL+ L+ S + ML
Sbjct: 3 EFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSML 62
Query: 251 VD-----ERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEH 305
+ +R + IE + ++ +DL + ++E+ E+ + +T + K + ++L K + E
Sbjct: 63 AEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEK 122
Query: 306 KASRFSQEHE---EMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQEL 362
FS+ ++ L + + +++ +L L +++ELE + L K E+ L
Sbjct: 123 LEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASE 182
Query: 363 RDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHS---- 418
+K+ SL + RK + E E ++E++ K +Q E KK+ + +
Sbjct: 183 LEKL-------KSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNL 235
Query: 419 --KELRLE-------VEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNE 469
+LR+E K +R L+ L++ ++++++ ++ N +E N KDL E
Sbjct: 236 ERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNK-SENEKNRNQEDNKVKDLNQE 294
Query: 470 LEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGL 529
+E +K+++K E E L+K + S +DL L ++ KN + + EE K+ +
Sbjct: 295 IEKLKTQIKHFESLEEELKKMK-SKNNDLQ-----DNYLSEQNKNKLLASQLEEIKLQ-I 347
Query: 530 NKNFKVEQGKV 540
K ++E G+V
Sbjct: 348 KKQKELENGEV 358
Score = 80.9 bits (198), Expect = 7e-15
Identities = 87/346 (25%), Positives = 149/346 (43%), Gaps = 48/346 (13%)
Query: 194 MNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKL------------RDELV 241
+++ ++ T L++ + L L Q+K QA E N+ L ++ +DE +
Sbjct: 27 LDELEEATKNLQKAEDELLDL--QDKVIQA--EGSNSSMLAEIEVLRQRVLRIEGKDEEI 82
Query: 242 KLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEV 301
K L+ E+ E L + + + QK E EKL+ S+SK D +L
Sbjct: 83 KRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN 142
Query: 302 DFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEE-----------TNK 350
+ + + S E E + K+ ES +L L +E+L+ N+
Sbjct: 143 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 202
Query: 351 NLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEME---------------GKDE 395
++ E+ ++EL K+ + + N NL + L +E G +
Sbjct: 203 KEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLD 262
Query: 396 EITKTESQCR---ELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQL 452
+ + E++ R E K +E++ K+L E+EKL+ ++ E LEE K KS+ L
Sbjct: 263 YLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDL 322
Query: 453 HLNLEKEKNLTKDLLNELEVVKSRV---KELECSESRLEKAELSLK 495
N E+N K L ++LE +K ++ KELE E E A LS K
Sbjct: 323 QDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSK 368
Score = 46.6 bits (109), Expect = 1e-04
Identities = 72/319 (22%), Positives = 130/319 (40%), Gaps = 32/319 (10%)
Query: 23 IIGNAGEKSLSEDAKKKKKSNRKEDDVMA---SGTVKRHLKTSGECERKTKKSLELSKED 79
I G E +ED + K +E++ + ++R K E E K +++ SK D
Sbjct: 75 IEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELE-KLEEAFSRSKND 133
Query: 80 LIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSI 139
QL + E + + L+ + K + LE S+E R+ + LA E
Sbjct: 134 CTQLCLSLNEERNLTKKISSELEMLRVKVKELE----SSED----RLDKTEQSLASELEK 185
Query: 140 GEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDD 199
+ + +SE L EK+KE + + E E+ + N + + + D
Sbjct: 186 LKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDG 245
Query: 200 FTNLLEQERERLK------KLLEQEKAYQARKEKENAKRLNKLRD---ELVKLKSFALML 250
++ L + R K K +E E ++ EK + NK++D E+ KLK+
Sbjct: 246 ISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT----Q 301
Query: 251 VDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRF 310
+ + E+L K DL E+ K K + S+ +E +KL++ + +
Sbjct: 302 IKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEE-----IKLQIKKQKELENG 356
Query: 311 SQEHEEMNAKLANQESHNR 329
E E+ A L+++ H R
Sbjct: 357 EVEGED--AFLSSKGRHER 373
>gi|216548085 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 322 bits (826), Expect = 1e-87
Identities = 224/582 (38%), Positives = 320/582 (54%), Gaps = 68/582 (11%)
Query: 324 QESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENL 383
+ + +R LR KL L++R++ELEE KNLQKAE+EL +L+DK+ + E NSS++AE+E L
Sbjct: 9 ETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVL 68
Query: 384 RKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFS 443
R+RVL +EGKDEEI + E CR +++KL+EEE+ ++EL+ E+E+LQKRM+ELEKLEEAFS
Sbjct: 69 RQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFS 128
Query: 444 KSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKS 503
+SK++CTQL L+L +E+NLTK + +ELE+++ +VKELE SE RL+K E SL +L KLKS
Sbjct: 129 RSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKS 188
Query: 504 FTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEE 563
T+ V ERK + EK K+ E+ + L + K+EQ K K+ +
Sbjct: 189 LTLSFVSERKYLNEKEKENEKLIKELTQ--KLEQNK----------------KMNRDYTR 230
Query: 564 KVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTC 623
NL R L+ E+ SS L K LD +++VE E TR +S
Sbjct: 231 NASNLERN------DLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNKSENEKNRN- 282
Query: 624 PEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEE 683
EDNK+K+L EIE+LK +++ E +E +L K + + + L+ + +EQ+K L+ QLEE
Sbjct: 283 QEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEE 342
Query: 684 IKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQ 743
IK QI K K +E GEV ++A L + R E K R +E K EL + +
Sbjct: 343 IKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKR--- 399
Query: 744 LQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTST 803
L+ R N+N ++ ++ PS RR +
Sbjct: 400 -----ERLRNREFALNNENYSLSNRQVS---------------SPSFTNRRA--AKASHM 437
Query: 804 GVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERSSVLDRYPPAANEL 863
GV TD SG ++T F+ S Q E KK E+ SVL RYPPAA E
Sbjct: 438 GVSTD--SGTQETKKTEDRFVPGSSQSEG-----------KKSREQPSVLSRYPPAAQEH 484
Query: 864 TMRKSWIPWMRK-RENGPSITQEKGPRTNSSPGHPGEVVLSP 904
+ K+W + E+G EK RT S H G V P
Sbjct: 485 S--KAWKGTSKPGTESGLKGKVEKTTRTFSDTTH-GSVPSDP 523
Score = 82.8 bits (203), Expect = 2e-15
Identities = 87/371 (23%), Positives = 174/371 (46%), Gaps = 44/371 (11%)
Query: 199 DFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLK--------SFALML 250
+FT+ E R + Q + + + +E K L K DEL+ L+ S + ML
Sbjct: 3 EFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSML 62
Query: 251 VD-----ERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEH 305
+ +R + IE + ++ +DL + ++E+ E+ + +T + K + ++L K + E
Sbjct: 63 AEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEK 122
Query: 306 KASRFSQEHE---EMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQEL 362
FS+ ++ L + + +++ +L L +++ELE + L K E+ L
Sbjct: 123 LEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASE 182
Query: 363 RDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHS---- 418
+K+ SL + RK + E E ++E++ K +Q E KK+ + +
Sbjct: 183 LEKL-------KSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNL 235
Query: 419 --KELRLE-------VEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNE 469
+LR+E K +R L+ L++ ++++++ ++ N +E N KDL E
Sbjct: 236 ERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNK-SENEKNRNQEDNKVKDLNQE 294
Query: 470 LEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGL 529
+E +K+++K E E L+K + S +DL L ++ KN + + EE K+ +
Sbjct: 295 IEKLKTQIKHFESLEEELKKMK-SKNNDLQ-----DNYLSEQNKNKLLASQLEEIKLQ-I 347
Query: 530 NKNFKVEQGKV 540
K ++E G+V
Sbjct: 348 KKQKELENGEV 358
Score = 80.9 bits (198), Expect = 7e-15
Identities = 87/346 (25%), Positives = 149/346 (43%), Gaps = 48/346 (13%)
Query: 194 MNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKL------------RDELV 241
+++ ++ T L++ + L L Q+K QA E N+ L ++ +DE +
Sbjct: 27 LDELEEATKNLQKAEDELLDL--QDKVIQA--EGSNSSMLAEIEVLRQRVLRIEGKDEEI 82
Query: 242 KLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEV 301
K L+ E+ E L + + + QK E EKL+ S+SK D +L
Sbjct: 83 KRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN 142
Query: 302 DFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEE-----------TNK 350
+ + + S E E + K+ ES +L L +E+L+ N+
Sbjct: 143 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 202
Query: 351 NLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEME---------------GKDE 395
++ E+ ++EL K+ + + N NL + L +E G +
Sbjct: 203 KEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLD 262
Query: 396 EITKTESQCR---ELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQL 452
+ + E++ R E K +E++ K+L E+EKL+ ++ E LEE K KS+ L
Sbjct: 263 YLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDL 322
Query: 453 HLNLEKEKNLTKDLLNELEVVKSRV---KELECSESRLEKAELSLK 495
N E+N K L ++LE +K ++ KELE E E A LS K
Sbjct: 323 QDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSK 368
Score = 46.6 bits (109), Expect = 1e-04
Identities = 72/319 (22%), Positives = 130/319 (40%), Gaps = 32/319 (10%)
Query: 23 IIGNAGEKSLSEDAKKKKKSNRKEDDVMA---SGTVKRHLKTSGECERKTKKSLELSKED 79
I G E +ED + K +E++ + ++R K E E K +++ SK D
Sbjct: 75 IEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELE-KLEEAFSRSKND 133
Query: 80 LIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSI 139
QL + E + + L+ + K + LE S+E R+ + LA E
Sbjct: 134 CTQLCLSLNEERNLTKKISSELEMLRVKVKELE----SSED----RLDKTEQSLASELEK 185
Query: 140 GEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDD 199
+ + +SE L EK+KE + + E E+ + N + + + D
Sbjct: 186 LKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDG 245
Query: 200 FTNLLEQERERLK------KLLEQEKAYQARKEKENAKRLNKLRD---ELVKLKSFALML 250
++ L + R K K +E E ++ EK + NK++D E+ KLK+
Sbjct: 246 ISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT----Q 301
Query: 251 VDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRF 310
+ + E+L K DL E+ K K + S+ +E +KL++ + +
Sbjct: 302 IKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEE-----IKLQIKKQKELENG 356
Query: 311 SQEHEEMNAKLANQESHNR 329
E E+ A L+++ H R
Sbjct: 357 EVEGED--AFLSSKGRHER 373
>gi|24308179 CTTNBP2 N-terminal like [Homo sapiens]
Length = 639
Score = 151 bits (381), Expect = 4e-36
Identities = 94/286 (32%), Positives = 158/286 (55%), Gaps = 3/286 (1%)
Query: 74 ELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAIL 133
+LSK +L+ L SI+EGEL+AR+ VI LK + + +E YG L L RD
Sbjct: 5 KLSKPELLTLFSILEGELEARDLVIEALKAQH-RDTFIEERYGKYNISDPLMALQRDFET 63
Query: 134 AQEKSIGED--VYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHT 191
+EK+ GE V P+S L + ++ K RML QL AE HR+ + +LE E+ +H
Sbjct: 64 LKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHA 123
Query: 192 DYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLV 251
+ DD T +LE+ERERL + LE EK+ + EKE K ++L +E + K + MLV
Sbjct: 124 QDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLV 183
Query: 252 DERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFS 311
E + + + QK +L+ KL +E+ ++ + + +R++ L+ E E + S F
Sbjct: 184 LECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFD 243
Query: 312 QEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEE 357
E E++ AKL +E+ + L+ ++ L + +++LE ++++ E+
Sbjct: 244 IEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQ 289
Score = 72.0 bits (175), Expect = 3e-12
Identities = 51/202 (25%), Positives = 106/202 (52%), Gaps = 12/202 (5%)
Query: 403 QCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNL 462
QC+ +++++ + L + +K + +LE+ + ++ +E + LEKE+
Sbjct: 89 QCKNMQERMLSQ------LAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKER-- 140
Query: 463 TKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQE 522
+ L +LE KS+VK+ E + +L L+++ ++ K + MLV E K K +E
Sbjct: 141 -ERLTQQLEFEKSQVKKFEKEQKKLSS---QLEEERSRHKQLSSMLVLECKKATNKAAEE 196
Query: 523 ERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSE 582
+K L+ + E+ +V + E+L E K+ L+ ++++E+++ ER++L KL E
Sbjct: 197 GQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNRE 256
Query: 583 EEKSSELSCSVDLLKKRLDGIE 604
E ++ L ++ LKK + +E
Sbjct: 257 ENRTKTLKEEMESLKKIVKDLE 278
Score = 61.6 bits (148), Expect = 4e-09
Identities = 81/312 (25%), Positives = 135/312 (43%), Gaps = 53/312 (16%)
Query: 229 NAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQ-----------KVQDLTQKLRE 277
N ++L+K EL+ L S ++ R + IE L Q + + D L+
Sbjct: 2 NLEKLSK--PELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQR 59
Query: 278 EEEKLKAITSKSKE----DRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRL 333
+ E LK K+ + +LK+ + + E M ++LA ES +R++ L
Sbjct: 60 DFETLKEKNDGEKQPVCTNPLSILKVVM------KQCKNMQERMLSQLAAAESRHRKVIL 113
Query: 334 KLVGLTQR----IEELEETNKNLQKAEEEL-QEL---RDKIAKGECGNSSLMAEVENLRK 385
L QR E ++ L+K E L Q+L + ++ K E L +++E R
Sbjct: 114 DLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERS 173
Query: 386 RVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEK-------- 437
R ++ + +C++ K EE + EL L++EK + R+S+LE+
Sbjct: 174 RHKQLS------SMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKR 227
Query: 438 -------LEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKA 490
+E+ S+ E QL L +E+N TK L E+E +K VK+LE S
Sbjct: 228 GLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPN 287
Query: 491 ELSLKDDLTKLK 502
E LK +T K
Sbjct: 288 E-QLKKPVTVSK 298
Score = 60.1 bits (144), Expect = 1e-08
Identities = 82/317 (25%), Positives = 140/317 (44%), Gaps = 40/317 (12%)
Query: 631 ELTLEIERLKKRL-QQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIA 689
++T +E+ ++RL QQLE + + K E E +L + E+ + LS L ++ + A
Sbjct: 131 DVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLV-LECKKA 189
Query: 690 KNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNK---EDQLSQLQV 746
NKA E+G+ + + +LE+ KSR K E + E+ L + E QLS+ +
Sbjct: 190 TNKAAEEGQKAGELS-----LKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDI 244
Query: 747 DYSVLQQRFMEEENKNKNMGQEVLNL---TKELELSKRYSRALRPSVNGRRMVDVPVT-S 802
+ L+ + EEN+ K + +E+ +L K+LE S ++S + + PVT S
Sbjct: 245 EREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHS-------SPNEQLKKPVTVS 297
Query: 803 TGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQV---GLKKP-------VERSSV 852
G T+ + + +T +SF E SN+ ++ GL P + +
Sbjct: 298 KGTATEPLMLMSVFCQT------ESFPAERTHGSNIAKMTNTGLPGPATPAYSYAKTNGH 351
Query: 853 LDRYPPAANELTMRKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEVVLSPKQGQPLHI 912
D ELT + + RE ++ QEK P N G P + PL
Sbjct: 352 CDPEIQTTRELTAGNNVENQVPPREKSVALAQEK-PVENG--GCPVGIETPVPMPSPLSS 408
Query: 913 RVTPDHENSTATLEITS 929
+ +STA+ +TS
Sbjct: 409 SGSSLSPSSTASSSLTS 425
Score = 57.4 bits (137), Expect = 8e-08
Identities = 72/310 (23%), Positives = 142/310 (45%), Gaps = 38/310 (12%)
Query: 389 EMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSE 448
E+E +D I ++Q R+ EE + + + LQ+ L++ + + +
Sbjct: 21 ELEARDLVIEALKAQHRDT---FIEERYGKYNISDPLMALQRDFETLKEKNDG--EKQPV 75
Query: 449 CTQ----LHLNLEKEKNLTKDLLNELEVVKSRVKE--LECSESRLEKAELSLKDDLTKLK 502
CT L + +++ KN+ + +L++L +SR ++ L+ E R A+ + + D
Sbjct: 76 CTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGD----- 130
Query: 503 SFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEME 562
T ML ER+ + ++++ E+ +V K F+ EQ K+ +EE + K S M
Sbjct: 131 DVTYMLEKERERLTQQLEFEKSQV----KKFEKEQKKL----SSQLEEERSRHKQLSSM- 181
Query: 563 EKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELT 622
L E + K E +K+ ELS ++ K R+ +EE E+ R R G +
Sbjct: 182 -----LVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEE---ELAAERKR-GLQTE 232
Query: 623 CPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLE 682
+ ++ E +E E+L+ +L + E + KT E + +K + + ++ S E
Sbjct: 233 AQVEKQLSEFDIEREQLRAKLNR----EENRTKTLKEEMESLKKIVKDLEASHQHSSPNE 288
Query: 683 EIKHQIAKNK 692
++K + +K
Sbjct: 289 QLKKPVTVSK 298
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 137 bits (345), Expect = 6e-32
Identities = 194/848 (22%), Positives = 364/848 (42%), Gaps = 142/848 (16%)
Query: 88 EGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGE-DVYEK 146
E E+QA+ED + +KTK +A E E+ L + L QE+ E ++Y +
Sbjct: 851 EEEMQAKEDEL-----QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 147 PISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQ 206
RL K++E LE++L +E+E + D + + Q
Sbjct: 906 AEEMRVRLAAKKQE-----LEEIL----------HEMEARLEEEEDRGQQLQAERKKMAQ 950
Query: 207 ERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQ 266
+ L++ LE+E+A + + + E K++ KL+ L++ D+ ++ L +
Sbjct: 951 QMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 267 KVQDLTQKLREEEEKLKAIT-----------------SKSKEDRQKLLKLEVDFEHKASR 309
++ DLT L EEEEK K +T K ++ RQ+L KL+ E AS
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Query: 310 FSQEHEEMNAKLANQE----SHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDK 365
F ++ ++ A++A + +L+ L L I + K +++ E + +L++
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 366 I-------AKGECGNSSLMAEVENLRKRV---LEMEGKDEEI-TKTESQCRELRKKLQEE 414
+ K E L E+E L+ + L+ +E+ K E + L+K L EE
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186
Query: 415 -EHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEV- 472
H +++ +K + + EL + E F ++K+ + LEKE DL EL V
Sbjct: 1187 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE---NADLAGELRVL 1243
Query: 473 -------------VKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKI 519
++++V+EL+ S E+A L D + KL+ +E +++ +
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-------NEVESVTGML 1296
Query: 520 KQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKS---EMEEKVYNLTRERDELI 576
+ E K L K+ ++ D E L EE+++ L + + ++EE+ +L + DE +
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 577 GKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSE---------------- 620
++ E S L+ + KK+L + G+ R E
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 621 ---------------LTCPEDNKIKELTLEIERLKKRLQQLEVVEGDL-MKTEDEYDQLE 664
L DN+ ++L +E+ +++ QL E ++ K DE D+ E
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 665 QKFRTEQDKANFLSQQLE---EIKHQIAKNKAIEKGE---VVSQEAELRHRFRLEEAKSR 718
+ R ++ KA L++ LE E K ++ + + K E +VS + ++ E R
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 719 DLKAEVQALKEKIHELMNK----EDQLSQLQVDYSV--------LQQRFMEEENKNKNMG 766
L+ +++ +K ++ EL ++ ED +L+V+ LQ R + E K + +
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 767 QEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTD-AVSG--EAAEEETPAVF 823
+++ ELE +R RAL + ++ ++ + +Q D A+ G EA ++
Sbjct: 1596 RQLHEYETELE-DERKQRAL--AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652
Query: 824 IRKSFQEE 831
K FQ E
Sbjct: 1653 QMKDFQRE 1660
Score = 115 bits (287), Expect = 3e-25
Identities = 185/889 (20%), Positives = 362/889 (40%), Gaps = 160/889 (17%)
Query: 13 DGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKE--------DDVMASGTVKRHLKTSGE 64
+GHIS + + E++ A+K+K+ +E +D + S ++ L+ E
Sbjct: 1117 EGHISDLQEDL---DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1173
Query: 65 CERKT-KKSL-ELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEK 122
E KK+L E ++ Q+ + + QA E++ L+ K L+ + + E E
Sbjct: 1174 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 123 VLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYE 182
+ +L Q K E +K +++ L+ K + R E L +K H+
Sbjct: 1234 A-DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKVHK----- 1284
Query: 183 LENEKHKHTDYMNKSD------------------DFTNLLEQERE-------RLKKLLEQ 217
L+NE T +N+++ D LL++E +L++L E+
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344
Query: 218 EKAYQARKEKENAKRLN----------KLRDELVKLKSFALML-------------VDER 254
+ Q + ++E + N +L D KL+ FA + ++
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 255 QMHIEQLGLQSQKVQDLTQKLREEEEKL-------KAITSKSKEDRQKLLKLEVDFEHKA 307
E+ K++ +L++E + L + + S ++ ++K +L + ++ +
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464
Query: 308 SRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIA 367
S+++ E + A+ +E+ L L + EELE TNK L+ E+L +D +
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 368 KG----ECGNSSLMAEVENLRKRVLEMEGK----------------------DEEITKTE 401
K E +L ++E ++ ++ E+E + + ++ +
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 402 SQCRELRKKLQEEEHHSKELRLEVE------------KLQKRMSELEKLEEAFSKSKSEC 449
Q E R++LQ + H E LE E KL+ + +LE ++ K + E
Sbjct: 1585 EQNEEKRRQLQ-RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643
Query: 450 TQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLV 509
+ L K + KD ELE ++ E+ + EK SL+ DL +L+
Sbjct: 1644 IK---QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 510 DERKNM-MEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNL 568
RK +EK + E L+ + + D +L ++ +L+ E+EE+ N+
Sbjct: 1701 RARKQADLEKEELAEELASSLS-----GRNALQDEKRRL---EARIAQLEEELEEEQGNM 1752
Query: 569 TRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNK 628
D + + E+ S+EL+ +K +++ER+ RS K E+ +K
Sbjct: 1753 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-KLHEMEGAVKSK 1811
Query: 629 IKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQI 688
K I L+ ++ QLE +Q+EQ+ R +Q L Q+ +++K +
Sbjct: 1812 FKS---TIAALEAKIAQLE-------------EQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 689 AKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDY 748
+ V E ++ +++ + K A V+ LK ++ E E++ ++ +
Sbjct: 1856 LQ---------VEDERKMAEQYKEQAEKG---NARVKQLKRQLEE---AEEESQRINANR 1900
Query: 749 SVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVD 797
LQ+ E N+ MG+EV L +L S GRR+++
Sbjct: 1901 RKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1949
Score = 109 bits (272), Expect = 2e-23
Identities = 147/629 (23%), Positives = 277/629 (44%), Gaps = 75/629 (11%)
Query: 203 LLEQERERLKKLLEQEKAYQARKEKENAKR-LNKLRDELVKLKSFALMLVDERQMHIEQL 261
L E ER K+ + A+QA A++ K + +L +K ++ Q
Sbjct: 775 LAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQW 834
Query: 262 GLQSQKVQDLTQKLREEEEKL--KAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNA 319
KV+ L Q R+EEE + K+KE +QK + E K S+ ++E +
Sbjct: 835 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 894
Query: 320 KLANQE---SHNRQLRLKLVGLTQRIEE-LEETNKNLQKAEEELQEL---RDKIAKGECG 372
+L + + ++R++L Q +EE L E L++ E+ Q+L R K+A+
Sbjct: 895 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 373 NSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRM 432
+ E E R+++ + E++T E++ ++L ++ + + +L E + L++R+
Sbjct: 955 LEEQLEEEEAARQKL-----QLEKVT-AEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008
Query: 433 SEL-EKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAE 491
S+L L E K+K NL K KN + +++ELEV R+K+ E S LEK +
Sbjct: 1009 SDLTTNLAEEEEKAK--------NLTKLKNKHESMISELEV---RLKKEEKSRQELEKLK 1057
Query: 492 LSLKDD--------------LTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQ 537
L+ D + +LK +E + + ++ E + + K + +
Sbjct: 1058 RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1117
Query: 538 GKVMDVTEKLIEE---SKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVD 594
G + D+ E L E K K K ++ E++ L E ++ + +++E ++ V
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Query: 595 LLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLK-------KRLQQLE 647
+LKK LD E TR + E+ ++ELT ++E+ K K Q LE
Sbjct: 1178 VLKKALD-------EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Query: 648 VVEGDL-----------MKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAK-NKAIE 695
DL + E + +LE + + Q K + + E+ ++ K +E
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 696 KGEVVSQEAELRHRFRLEE---AKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQ 752
+ EAE + +L + + S L+ + L+E+ + +N +L QL+ + + LQ
Sbjct: 1291 SVTGMLNEAEGK-AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 753 QRFMEEENKNKNMGQEVLNLTKELELSKR 781
+ EE +N+ + + L +L SK+
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Score = 90.1 bits (222), Expect = 1e-17
Identities = 103/479 (21%), Positives = 224/479 (46%), Gaps = 49/479 (10%)
Query: 385 KRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSK 444
K +L++ ++EE+ E + ++ +++ Q+ E+ KEL + +L + + L++ +A ++
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 445 SKSECTQLHLNLEKEKNLTKDLLNE----LEVVKSRVKELECSESRLEKAELSLKDDLTK 500
+E ++ + L +K +++L+E LE + R ++L+ ++ + L L++ L +
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 501 LKSFTVMLVDERKNMMEKIKQEERKV-------DGLNKNFKVEQGKVMDVTEKLIEE--- 550
++ L E+ KIK+ E ++ + L+K K+ + ++ D+T L EE
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 551 SKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREI 610
+K L KLK++ E + EL +LK EE+ EL + LK++L+G E
Sbjct: 1022 AKNLTKLKNKHESMI-------SELEVRLKKEEKSRQEL----EKLKRKLEGDASDFHEQ 1070
Query: 611 TRGRSRKGSELTCPEDNKIKELTLEIERL-------KKRLQQLEVVEGDLMKTEDEYDQL 663
+ +EL K +EL + RL L+++ +EG + +++ D
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 664 EQKFRTEQDKANFLSQQLEEIKHQI---AKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL 720
+ + L ++LE +K ++ + A ++ +E E+ + + ++R
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 721 KAEVQALKEK----IHELMNKEDQLSQLQVDYSVLQQRFMEEENKN-----KNMG---QE 768
+A+VQ +++K + EL + +Q + + + +Q +E+EN + + +G QE
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT-LEKENADLAGELRVLGQAKQE 1249
Query: 769 VLNLTKELELS-KRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRK 826
V + K+LE + R ++ V + ++V+G E E A+ + K
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 137 bits (345), Expect = 6e-32
Identities = 194/848 (22%), Positives = 364/848 (42%), Gaps = 142/848 (16%)
Query: 88 EGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGE-DVYEK 146
E E+QA+ED + +KTK +A E E+ L + L QE+ E ++Y +
Sbjct: 858 EEEMQAKEDEL-----QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 147 PISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQ 206
RL K++E LE++L +E+E + D + + Q
Sbjct: 913 AEEMRVRLAAKKQE-----LEEIL----------HEMEARLEEEEDRGQQLQAERKKMAQ 957
Query: 207 ERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQ 266
+ L++ LE+E+A + + + E K++ KL+ L++ D+ ++ L +
Sbjct: 958 QMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 267 KVQDLTQKLREEEEKLKAIT-----------------SKSKEDRQKLLKLEVDFEHKASR 309
++ DLT L EEEEK K +T K ++ RQ+L KL+ E AS
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Query: 310 FSQEHEEMNAKLANQE----SHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDK 365
F ++ ++ A++A + +L+ L L I + K +++ E + +L++
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 366 I-------AKGECGNSSLMAEVENLRKRV---LEMEGKDEEI-TKTESQCRELRKKLQEE 414
+ K E L E+E L+ + L+ +E+ K E + L+K L EE
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193
Query: 415 -EHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEV- 472
H +++ +K + + EL + E F ++K+ + LEKE DL EL V
Sbjct: 1194 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE---NADLAGELRVL 1250
Query: 473 -------------VKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKI 519
++++V+EL+ S E+A L D + KL+ +E +++ +
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-------NEVESVTGML 1303
Query: 520 KQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKS---EMEEKVYNLTRERDELI 576
+ E K L K+ ++ D E L EE+++ L + + ++EE+ +L + DE +
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 577 GKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSE---------------- 620
++ E S L+ + KK+L + G+ R E
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 621 ---------------LTCPEDNKIKELTLEIERLKKRLQQLEVVEGDL-MKTEDEYDQLE 664
L DN+ ++L +E+ +++ QL E ++ K DE D+ E
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 665 QKFRTEQDKANFLSQQLE---EIKHQIAKNKAIEKGE---VVSQEAELRHRFRLEEAKSR 718
+ R ++ KA L++ LE E K ++ + + K E +VS + ++ E R
Sbjct: 1483 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 719 DLKAEVQALKEKIHELMNK----EDQLSQLQVDYSV--------LQQRFMEEENKNKNMG 766
L+ +++ +K ++ EL ++ ED +L+V+ LQ R + E K + +
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 767 QEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTD-AVSG--EAAEEETPAVF 823
+++ ELE +R RAL + ++ ++ + +Q D A+ G EA ++
Sbjct: 1603 RQLHEYETELE-DERKQRAL--AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659
Query: 824 IRKSFQEE 831
K FQ E
Sbjct: 1660 QMKDFQRE 1667
Score = 115 bits (287), Expect = 3e-25
Identities = 185/889 (20%), Positives = 362/889 (40%), Gaps = 160/889 (17%)
Query: 13 DGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKE--------DDVMASGTVKRHLKTSGE 64
+GHIS + + E++ A+K+K+ +E +D + S ++ L+ E
Sbjct: 1124 EGHISDLQEDL---DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1180
Query: 65 CERKT-KKSL-ELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEK 122
E KK+L E ++ Q+ + + QA E++ L+ K L+ + + E E
Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 123 VLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYE 182
+ +L Q K E +K +++ L+ K + R E L +K H+
Sbjct: 1241 A-DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKVHK----- 1291
Query: 183 LENEKHKHTDYMNKSD------------------DFTNLLEQERE-------RLKKLLEQ 217
L+NE T +N+++ D LL++E +L++L E+
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351
Query: 218 EKAYQARKEKENAKRLN----------KLRDELVKLKSFALML-------------VDER 254
+ Q + ++E + N +L D KL+ FA + ++
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 255 QMHIEQLGLQSQKVQDLTQKLREEEEKL-------KAITSKSKEDRQKLLKLEVDFEHKA 307
E+ K++ +L++E + L + + S ++ ++K +L + ++ +
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471
Query: 308 SRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIA 367
S+++ E + A+ +E+ L L + EELE TNK L+ E+L +D +
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 368 KG----ECGNSSLMAEVENLRKRVLEMEGK----------------------DEEITKTE 401
K E +L ++E ++ ++ E+E + + ++ +
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 402 SQCRELRKKLQEEEHHSKELRLEVE------------KLQKRMSELEKLEEAFSKSKSEC 449
Q E R++LQ + H E LE E KL+ + +LE ++ K + E
Sbjct: 1592 EQNEEKRRQLQ-RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650
Query: 450 TQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLV 509
+ L K + KD ELE ++ E+ + EK SL+ DL +L+
Sbjct: 1651 IK---QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 510 DERKNM-MEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNL 568
RK +EK + E L+ + + D +L ++ +L+ E+EE+ N+
Sbjct: 1708 RARKQADLEKEELAEELASSLS-----GRNALQDEKRRL---EARIAQLEEELEEEQGNM 1759
Query: 569 TRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNK 628
D + + E+ S+EL+ +K +++ER+ RS K E+ +K
Sbjct: 1760 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-KLHEMEGAVKSK 1818
Query: 629 IKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQI 688
K I L+ ++ QLE +Q+EQ+ R +Q L Q+ +++K +
Sbjct: 1819 FKS---TIAALEAKIAQLE-------------EQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 689 AKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDY 748
+ V E ++ +++ + K A V+ LK ++ E E++ ++ +
Sbjct: 1863 LQ---------VEDERKMAEQYKEQAEKG---NARVKQLKRQLEE---AEEESQRINANR 1907
Query: 749 SVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVD 797
LQ+ E N+ MG+EV L +L S GRR+++
Sbjct: 1908 RKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1956
Score = 109 bits (272), Expect = 2e-23
Identities = 147/629 (23%), Positives = 277/629 (44%), Gaps = 75/629 (11%)
Query: 203 LLEQERERLKKLLEQEKAYQARKEKENAKR-LNKLRDELVKLKSFALMLVDERQMHIEQL 261
L E ER K+ + A+QA A++ K + +L +K ++ Q
Sbjct: 782 LAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQW 841
Query: 262 GLQSQKVQDLTQKLREEEEKL--KAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNA 319
KV+ L Q R+EEE + K+KE +QK + E K S+ ++E +
Sbjct: 842 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 901
Query: 320 KLANQE---SHNRQLRLKLVGLTQRIEE-LEETNKNLQKAEEELQEL---RDKIAKGECG 372
+L + + ++R++L Q +EE L E L++ E+ Q+L R K+A+
Sbjct: 902 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 373 NSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRM 432
+ E E R+++ + E++T E++ ++L ++ + + +L E + L++R+
Sbjct: 962 LEEQLEEEEAARQKL-----QLEKVT-AEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015
Query: 433 SEL-EKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAE 491
S+L L E K+K NL K KN + +++ELEV R+K+ E S LEK +
Sbjct: 1016 SDLTTNLAEEEEKAK--------NLTKLKNKHESMISELEV---RLKKEEKSRQELEKLK 1064
Query: 492 LSLKDD--------------LTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQ 537
L+ D + +LK +E + + ++ E + + K + +
Sbjct: 1065 RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1124
Query: 538 GKVMDVTEKLIEE---SKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVD 594
G + D+ E L E K K K ++ E++ L E ++ + +++E ++ V
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Query: 595 LLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLK-------KRLQQLE 647
+LKK LD E TR + E+ ++ELT ++E+ K K Q LE
Sbjct: 1185 VLKKALD-------EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Query: 648 VVEGDL-----------MKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAK-NKAIE 695
DL + E + +LE + + Q K + + E+ ++ K +E
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 696 KGEVVSQEAELRHRFRLEE---AKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQ 752
+ EAE + +L + + S L+ + L+E+ + +N +L QL+ + + LQ
Sbjct: 1298 SVTGMLNEAEGK-AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 753 QRFMEEENKNKNMGQEVLNLTKELELSKR 781
+ EE +N+ + + L +L SK+
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Score = 90.1 bits (222), Expect = 1e-17
Identities = 103/479 (21%), Positives = 224/479 (46%), Gaps = 49/479 (10%)
Query: 385 KRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSK 444
K +L++ ++EE+ E + ++ +++ Q+ E+ KEL + +L + + L++ +A ++
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 445 SKSECTQLHLNLEKEKNLTKDLLNE----LEVVKSRVKELECSESRLEKAELSLKDDLTK 500
+E ++ + L +K +++L+E LE + R ++L+ ++ + L L++ L +
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 501 LKSFTVMLVDERKNMMEKIKQEERKV-------DGLNKNFKVEQGKVMDVTEKLIEE--- 550
++ L E+ KIK+ E ++ + L+K K+ + ++ D+T L EE
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 551 SKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREI 610
+K L KLK++ E + EL +LK EE+ EL + LK++L+G E
Sbjct: 1029 AKNLTKLKNKHESMI-------SELEVRLKKEEKSRQEL----EKLKRKLEGDASDFHEQ 1077
Query: 611 TRGRSRKGSELTCPEDNKIKELTLEIERL-------KKRLQQLEVVEGDLMKTEDEYDQL 663
+ +EL K +EL + RL L+++ +EG + +++ D
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 664 EQKFRTEQDKANFLSQQLEEIKHQI---AKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL 720
+ + L ++LE +K ++ + A ++ +E E+ + + ++R
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 721 KAEVQALKEK----IHELMNKEDQLSQLQVDYSVLQQRFMEEENKN-----KNMG---QE 768
+A+VQ +++K + EL + +Q + + + +Q +E+EN + + +G QE
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT-LEKENADLAGELRVLGQAKQE 1256
Query: 769 VLNLTKELELS-KRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRK 826
V + K+LE + R ++ V + ++V+G E E A+ + K
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 137 bits (345), Expect = 6e-32
Identities = 194/848 (22%), Positives = 364/848 (42%), Gaps = 142/848 (16%)
Query: 88 EGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGE-DVYEK 146
E E+QA+ED + +KTK +A E E+ L + L QE+ E ++Y +
Sbjct: 858 EEEMQAKEDEL-----QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 147 PISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQ 206
RL K++E LE++L +E+E + D + + Q
Sbjct: 913 AEEMRVRLAAKKQE-----LEEIL----------HEMEARLEEEEDRGQQLQAERKKMAQ 957
Query: 207 ERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQ 266
+ L++ LE+E+A + + + E K++ KL+ L++ D+ ++ L +
Sbjct: 958 QMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 267 KVQDLTQKLREEEEKLKAIT-----------------SKSKEDRQKLLKLEVDFEHKASR 309
++ DLT L EEEEK K +T K ++ RQ+L KL+ E AS
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Query: 310 FSQEHEEMNAKLANQE----SHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDK 365
F ++ ++ A++A + +L+ L L I + K +++ E + +L++
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 366 I-------AKGECGNSSLMAEVENLRKRV---LEMEGKDEEI-TKTESQCRELRKKLQEE 414
+ K E L E+E L+ + L+ +E+ K E + L+K L EE
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193
Query: 415 -EHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEV- 472
H +++ +K + + EL + E F ++K+ + LEKE DL EL V
Sbjct: 1194 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE---NADLAGELRVL 1250
Query: 473 -------------VKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKI 519
++++V+EL+ S E+A L D + KL+ +E +++ +
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-------NEVESVTGML 1303
Query: 520 KQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKS---EMEEKVYNLTRERDELI 576
+ E K L K+ ++ D E L EE+++ L + + ++EE+ +L + DE +
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 577 GKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSE---------------- 620
++ E S L+ + KK+L + G+ R E
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 621 ---------------LTCPEDNKIKELTLEIERLKKRLQQLEVVEGDL-MKTEDEYDQLE 664
L DN+ ++L +E+ +++ QL E ++ K DE D+ E
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 665 QKFRTEQDKANFLSQQLE---EIKHQIAKNKAIEKGE---VVSQEAELRHRFRLEEAKSR 718
+ R ++ KA L++ LE E K ++ + + K E +VS + ++ E R
Sbjct: 1483 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 719 DLKAEVQALKEKIHELMNK----EDQLSQLQVDYSV--------LQQRFMEEENKNKNMG 766
L+ +++ +K ++ EL ++ ED +L+V+ LQ R + E K + +
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 767 QEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTD-AVSG--EAAEEETPAVF 823
+++ ELE +R RAL + ++ ++ + +Q D A+ G EA ++
Sbjct: 1603 RQLHEYETELE-DERKQRAL--AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659
Query: 824 IRKSFQEE 831
K FQ E
Sbjct: 1660 QMKDFQRE 1667
Score = 111 bits (277), Expect = 5e-24
Identities = 181/868 (20%), Positives = 355/868 (40%), Gaps = 160/868 (18%)
Query: 13 DGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKE--------DDVMASGTVKRHLKTSGE 64
+GHIS + + E++ A+K+K+ +E +D + S ++ L+ E
Sbjct: 1124 EGHISDLQEDL---DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1180
Query: 65 CERKT-KKSL-ELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEK 122
E KK+L E ++ Q+ + + QA E++ L+ K L+ + + E E
Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 123 VLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYE 182
+ +L Q K E +K +++ L+ K + R E L +K H+
Sbjct: 1241 A-DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKVHK----- 1291
Query: 183 LENEKHKHTDYMNKSD------------------DFTNLLEQERE-------RLKKLLEQ 217
L+NE T +N+++ D LL++E +L++L E+
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351
Query: 218 EKAYQARKEKENAKRLN----------KLRDELVKLKSFALML-------------VDER 254
+ Q + ++E + N +L D KL+ FA + ++
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 255 QMHIEQLGLQSQKVQDLTQKLREEEEKL-------KAITSKSKEDRQKLLKLEVDFEHKA 307
E+ K++ +L++E + L + + S ++ ++K +L + ++ +
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471
Query: 308 SRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIA 367
S+++ E + A+ +E+ L L + EELE TNK L+ E+L +D +
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 368 KG----ECGNSSLMAEVENLRKRVLEMEGK----------------------DEEITKTE 401
K E +L ++E ++ ++ E+E + + ++ +
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 402 SQCRELRKKLQEEEHHSKELRLEVE------------KLQKRMSELEKLEEAFSKSKSEC 449
Q E R++LQ + H E LE E KL+ + +LE ++ K + E
Sbjct: 1592 EQNEEKRRQLQ-RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650
Query: 450 TQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLV 509
+ L K + KD ELE ++ E+ + EK SL+ DL +L+
Sbjct: 1651 IK---QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 510 DERKNM-MEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNL 568
RK +EK + E L+ + + D +L ++ +L+ E+EE+ N+
Sbjct: 1708 RARKQADLEKEELAEELASSLS-----GRNALQDEKRRL---EARIAQLEEELEEEQGNM 1759
Query: 569 TRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNK 628
D + + E+ S+EL+ +K +++ER+ RS K E+ +K
Sbjct: 1760 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-KLHEMEGAVKSK 1818
Query: 629 IKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQI 688
K I L+ ++ QLE +Q+EQ+ R +Q L Q+ +++K +
Sbjct: 1819 FKS---TIAALEAKIAQLE-------------EQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 689 AKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDY 748
+ V E ++ +++ + K A V+ LK ++ E E++ ++ +
Sbjct: 1863 LQ---------VEDERKMAEQYKEQAEKG---NARVKQLKRQLEE---AEEESQRINANR 1907
Query: 749 SVLQQRFMEEENKNKNMGQEVLNLTKEL 776
LQ+ E N+ MG+EV L +L
Sbjct: 1908 RKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 109 bits (273), Expect = 1e-23
Identities = 138/562 (24%), Positives = 247/562 (43%), Gaps = 52/562 (9%)
Query: 29 EKSLSEDAKKKKKSNRKE--DDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSI 86
EK+ + D +K K+ ++ DD++ +R L ++ E +++ L L++E I
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL-LAEEKNISSKYA 1475
Query: 87 ME---GELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDV 143
E E +ARE L + E LEA K+L+ D + +++ +G++V
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD-DVGKNV 1534
Query: 144 YEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNL 203
+E + + R E Q E + LE+L D + ++D
Sbjct: 1535 HE--LEKSKRALETQMEEMKTQLEEL---------------------EDELQATEDAKLR 1571
Query: 204 LEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGL 263
LE + LK E++ QAR E+ KR R +L + L DER+ Q L
Sbjct: 1572 LEVNMQALKGQFERD--LQARDEQNEEKRRQLQR----QLHEYETELEDERK----QRAL 1621
Query: 264 QSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEV---DFEHKASRFSQEHEEMNAK 320
+ + L L++ E + + +E ++L KL+ DF+ + +E+ A
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 321 LANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEV 380
E + L L+ L + + E K +A+ E +EL +++A G ++L E
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARK---QADLEKEELAEELASSLSGRNALQDEK 1738
Query: 381 ENLRKRVLEMEGK-DEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLE 439
L R+ ++E + +EE E+ +RK Q+ E S EL E QK S ++LE
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 440 EAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAEL-SLKDDL 498
++K ++LH K+ K + LE ++++E E+R ++A SLK
Sbjct: 1799 R---QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855
Query: 499 TKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLK 558
KLK + + DERK M E+ K++ K + K K + + + ++++ +KL +
Sbjct: 1856 KKLKEILLQVEDERK-MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Query: 559 SEMEEKVYNLTRERDELIGKLK 580
E E + RE + L KL+
Sbjct: 1915 DEATESNEAMGREVNALKSKLR 1936
Score = 109 bits (272), Expect = 2e-23
Identities = 147/629 (23%), Positives = 277/629 (44%), Gaps = 75/629 (11%)
Query: 203 LLEQERERLKKLLEQEKAYQARKEKENAKR-LNKLRDELVKLKSFALMLVDERQMHIEQL 261
L E ER K+ + A+QA A++ K + +L +K ++ Q
Sbjct: 782 LAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQW 841
Query: 262 GLQSQKVQDLTQKLREEEEKL--KAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNA 319
KV+ L Q R+EEE + K+KE +QK + E K S+ ++E +
Sbjct: 842 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 901
Query: 320 KLANQE---SHNRQLRLKLVGLTQRIEE-LEETNKNLQKAEEELQEL---RDKIAKGECG 372
+L + + ++R++L Q +EE L E L++ E+ Q+L R K+A+
Sbjct: 902 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 373 NSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRM 432
+ E E R+++ + E++T E++ ++L ++ + + +L E + L++R+
Sbjct: 962 LEEQLEEEEAARQKL-----QLEKVT-AEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015
Query: 433 SEL-EKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAE 491
S+L L E K+K NL K KN + +++ELEV R+K+ E S LEK +
Sbjct: 1016 SDLTTNLAEEEEKAK--------NLTKLKNKHESMISELEV---RLKKEEKSRQELEKLK 1064
Query: 492 LSLKDD--------------LTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQ 537
L+ D + +LK +E + + ++ E + + K + +
Sbjct: 1065 RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1124
Query: 538 GKVMDVTEKLIEE---SKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVD 594
G + D+ E L E K K K ++ E++ L E ++ + +++E ++ V
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Query: 595 LLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLK-------KRLQQLE 647
+LKK LD E TR + E+ ++ELT ++E+ K K Q LE
Sbjct: 1185 VLKKALD-------EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Query: 648 VVEGDL-----------MKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAK-NKAIE 695
DL + E + +LE + + Q K + + E+ ++ K +E
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 696 KGEVVSQEAELRHRFRLEE---AKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQ 752
+ EAE + +L + + S L+ + L+E+ + +N +L QL+ + + LQ
Sbjct: 1298 SVTGMLNEAEGK-AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 753 QRFMEEENKNKNMGQEVLNLTKELELSKR 781
+ EE +N+ + + L +L SK+
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Score = 90.1 bits (222), Expect = 1e-17
Identities = 103/479 (21%), Positives = 224/479 (46%), Gaps = 49/479 (10%)
Query: 385 KRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSK 444
K +L++ ++EE+ E + ++ +++ Q+ E+ KEL + +L + + L++ +A ++
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 445 SKSECTQLHLNLEKEKNLTKDLLNE----LEVVKSRVKELECSESRLEKAELSLKDDLTK 500
+E ++ + L +K +++L+E LE + R ++L+ ++ + L L++ L +
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 501 LKSFTVMLVDERKNMMEKIKQEERKV-------DGLNKNFKVEQGKVMDVTEKLIEE--- 550
++ L E+ KIK+ E ++ + L+K K+ + ++ D+T L EE
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 551 SKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREI 610
+K L KLK++ E + EL +LK EE+ EL + LK++L+G E
Sbjct: 1029 AKNLTKLKNKHESMI-------SELEVRLKKEEKSRQEL----EKLKRKLEGDASDFHEQ 1077
Query: 611 TRGRSRKGSELTCPEDNKIKELTLEIERL-------KKRLQQLEVVEGDLMKTEDEYDQL 663
+ +EL K +EL + RL L+++ +EG + +++ D
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 664 EQKFRTEQDKANFLSQQLEEIKHQI---AKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL 720
+ + L ++LE +K ++ + A ++ +E E+ + + ++R
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 721 KAEVQALKEK----IHELMNKEDQLSQLQVDYSVLQQRFMEEENKN-----KNMG---QE 768
+A+VQ +++K + EL + +Q + + + +Q +E+EN + + +G QE
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT-LEKENADLAGELRVLGQAKQE 1256
Query: 769 VLNLTKELELS-KRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRK 826
V + K+LE + R ++ V + ++V+G E E A+ + K
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 137 bits (345), Expect = 6e-32
Identities = 194/848 (22%), Positives = 364/848 (42%), Gaps = 142/848 (16%)
Query: 88 EGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGE-DVYEK 146
E E+QA+ED + +KTK +A E E+ L + L QE+ E ++Y +
Sbjct: 851 EEEMQAKEDEL-----QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 147 PISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQ 206
RL K++E LE++L +E+E + D + + Q
Sbjct: 906 AEEMRVRLAAKKQE-----LEEIL----------HEMEARLEEEEDRGQQLQAERKKMAQ 950
Query: 207 ERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQ 266
+ L++ LE+E+A + + + E K++ KL+ L++ D+ ++ L +
Sbjct: 951 QMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 267 KVQDLTQKLREEEEKLKAIT-----------------SKSKEDRQKLLKLEVDFEHKASR 309
++ DLT L EEEEK K +T K ++ RQ+L KL+ E AS
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Query: 310 FSQEHEEMNAKLANQE----SHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDK 365
F ++ ++ A++A + +L+ L L I + K +++ E + +L++
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 366 I-------AKGECGNSSLMAEVENLRKRV---LEMEGKDEEI-TKTESQCRELRKKLQEE 414
+ K E L E+E L+ + L+ +E+ K E + L+K L EE
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186
Query: 415 -EHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEV- 472
H +++ +K + + EL + E F ++K+ + LEKE DL EL V
Sbjct: 1187 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE---NADLAGELRVL 1243
Query: 473 -------------VKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKI 519
++++V+EL+ S E+A L D + KL+ +E +++ +
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-------NEVESVTGML 1296
Query: 520 KQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKS---EMEEKVYNLTRERDELI 576
+ E K L K+ ++ D E L EE+++ L + + ++EE+ +L + DE +
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 577 GKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSE---------------- 620
++ E S L+ + KK+L + G+ R E
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 621 ---------------LTCPEDNKIKELTLEIERLKKRLQQLEVVEGDL-MKTEDEYDQLE 664
L DN+ ++L +E+ +++ QL E ++ K DE D+ E
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 665 QKFRTEQDKANFLSQQLE---EIKHQIAKNKAIEKGE---VVSQEAELRHRFRLEEAKSR 718
+ R ++ KA L++ LE E K ++ + + K E +VS + ++ E R
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 719 DLKAEVQALKEKIHELMNK----EDQLSQLQVDYSV--------LQQRFMEEENKNKNMG 766
L+ +++ +K ++ EL ++ ED +L+V+ LQ R + E K + +
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 767 QEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTD-AVSG--EAAEEETPAVF 823
+++ ELE +R RAL + ++ ++ + +Q D A+ G EA ++
Sbjct: 1596 RQLHEYETELE-DERKQRAL--AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652
Query: 824 IRKSFQEE 831
K FQ E
Sbjct: 1653 QMKDFQRE 1660
Score = 111 bits (277), Expect = 5e-24
Identities = 181/868 (20%), Positives = 355/868 (40%), Gaps = 160/868 (18%)
Query: 13 DGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKE--------DDVMASGTVKRHLKTSGE 64
+GHIS + + E++ A+K+K+ +E +D + S ++ L+ E
Sbjct: 1117 EGHISDLQEDL---DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1173
Query: 65 CERKT-KKSL-ELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEK 122
E KK+L E ++ Q+ + + QA E++ L+ K L+ + + E E
Sbjct: 1174 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 123 VLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYE 182
+ +L Q K E +K +++ L+ K + R E L +K H+
Sbjct: 1234 A-DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKVHK----- 1284
Query: 183 LENEKHKHTDYMNKSD------------------DFTNLLEQERE-------RLKKLLEQ 217
L+NE T +N+++ D LL++E +L++L E+
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344
Query: 218 EKAYQARKEKENAKRLN----------KLRDELVKLKSFALML-------------VDER 254
+ Q + ++E + N +L D KL+ FA + ++
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 255 QMHIEQLGLQSQKVQDLTQKLREEEEKL-------KAITSKSKEDRQKLLKLEVDFEHKA 307
E+ K++ +L++E + L + + S ++ ++K +L + ++ +
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464
Query: 308 SRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIA 367
S+++ E + A+ +E+ L L + EELE TNK L+ E+L +D +
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 368 KG----ECGNSSLMAEVENLRKRVLEMEGK----------------------DEEITKTE 401
K E +L ++E ++ ++ E+E + + ++ +
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 402 SQCRELRKKLQEEEHHSKELRLEVE------------KLQKRMSELEKLEEAFSKSKSEC 449
Q E R++LQ + H E LE E KL+ + +LE ++ K + E
Sbjct: 1585 EQNEEKRRQLQ-RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643
Query: 450 TQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLV 509
+ L K + KD ELE ++ E+ + EK SL+ DL +L+
Sbjct: 1644 IK---QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 510 DERKNM-MEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNL 568
RK +EK + E L+ + + D +L ++ +L+ E+EE+ N+
Sbjct: 1701 RARKQADLEKEELAEELASSLS-----GRNALQDEKRRL---EARIAQLEEELEEEQGNM 1752
Query: 569 TRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNK 628
D + + E+ S+EL+ +K +++ER+ RS K E+ +K
Sbjct: 1753 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-KLHEMEGAVKSK 1811
Query: 629 IKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQI 688
K I L+ ++ QLE +Q+EQ+ R +Q L Q+ +++K +
Sbjct: 1812 FKS---TIAALEAKIAQLE-------------EQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 689 AKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDY 748
+ V E ++ +++ + K A V+ LK ++ E E++ ++ +
Sbjct: 1856 LQ---------VEDERKMAEQYKEQAEKG---NARVKQLKRQLEE---AEEESQRINANR 1900
Query: 749 SVLQQRFMEEENKNKNMGQEVLNLTKEL 776
LQ+ E N+ MG+EV L +L
Sbjct: 1901 RKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 109 bits (273), Expect = 1e-23
Identities = 138/562 (24%), Positives = 247/562 (43%), Gaps = 52/562 (9%)
Query: 29 EKSLSEDAKKKKKSNRKE--DDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSI 86
EK+ + D +K K+ ++ DD++ +R L ++ E +++ L L++E I
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL-LAEEKNISSKYA 1468
Query: 87 ME---GELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDV 143
E E +ARE L + E LEA K+L+ D + +++ +G++V
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD-DVGKNV 1527
Query: 144 YEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNL 203
+E + + R E Q E + LE+L D + ++D
Sbjct: 1528 HE--LEKSKRALETQMEEMKTQLEEL---------------------EDELQATEDAKLR 1564
Query: 204 LEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGL 263
LE + LK E++ QAR E+ KR R +L + L DER+ Q L
Sbjct: 1565 LEVNMQALKGQFERD--LQARDEQNEEKRRQLQR----QLHEYETELEDERK----QRAL 1614
Query: 264 QSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEV---DFEHKASRFSQEHEEMNAK 320
+ + L L++ E + + +E ++L KL+ DF+ + +E+ A
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 321 LANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEV 380
E + L L+ L + + E K +A+ E +EL +++A G ++L E
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARK---QADLEKEELAEELASSLSGRNALQDEK 1731
Query: 381 ENLRKRVLEMEGK-DEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLE 439
L R+ ++E + +EE E+ +RK Q+ E S EL E QK S ++LE
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 440 EAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAEL-SLKDDL 498
++K ++LH K+ K + LE ++++E E+R ++A SLK
Sbjct: 1792 R---QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848
Query: 499 TKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLK 558
KLK + + DERK M E+ K++ K + K K + + + ++++ +KL +
Sbjct: 1849 KKLKEILLQVEDERK-MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Query: 559 SEMEEKVYNLTRERDELIGKLK 580
E E + RE + L KL+
Sbjct: 1908 DEATESNEAMGREVNALKSKLR 1929
Score = 109 bits (272), Expect = 2e-23
Identities = 147/629 (23%), Positives = 277/629 (44%), Gaps = 75/629 (11%)
Query: 203 LLEQERERLKKLLEQEKAYQARKEKENAKR-LNKLRDELVKLKSFALMLVDERQMHIEQL 261
L E ER K+ + A+QA A++ K + +L +K ++ Q
Sbjct: 775 LAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQW 834
Query: 262 GLQSQKVQDLTQKLREEEEKL--KAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNA 319
KV+ L Q R+EEE + K+KE +QK + E K S+ ++E +
Sbjct: 835 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 894
Query: 320 KLANQE---SHNRQLRLKLVGLTQRIEE-LEETNKNLQKAEEELQEL---RDKIAKGECG 372
+L + + ++R++L Q +EE L E L++ E+ Q+L R K+A+
Sbjct: 895 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 373 NSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRM 432
+ E E R+++ + E++T E++ ++L ++ + + +L E + L++R+
Sbjct: 955 LEEQLEEEEAARQKL-----QLEKVT-AEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008
Query: 433 SEL-EKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAE 491
S+L L E K+K NL K KN + +++ELEV R+K+ E S LEK +
Sbjct: 1009 SDLTTNLAEEEEKAK--------NLTKLKNKHESMISELEV---RLKKEEKSRQELEKLK 1057
Query: 492 LSLKDD--------------LTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQ 537
L+ D + +LK +E + + ++ E + + K + +
Sbjct: 1058 RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1117
Query: 538 GKVMDVTEKLIEE---SKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVD 594
G + D+ E L E K K K ++ E++ L E ++ + +++E ++ V
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Query: 595 LLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLK-------KRLQQLE 647
+LKK LD E TR + E+ ++ELT ++E+ K K Q LE
Sbjct: 1178 VLKKALD-------EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Query: 648 VVEGDL-----------MKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAK-NKAIE 695
DL + E + +LE + + Q K + + E+ ++ K +E
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 696 KGEVVSQEAELRHRFRLEE---AKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQ 752
+ EAE + +L + + S L+ + L+E+ + +N +L QL+ + + LQ
Sbjct: 1291 SVTGMLNEAEGK-AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 753 QRFMEEENKNKNMGQEVLNLTKELELSKR 781
+ EE +N+ + + L +L SK+
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Score = 90.1 bits (222), Expect = 1e-17
Identities = 103/479 (21%), Positives = 224/479 (46%), Gaps = 49/479 (10%)
Query: 385 KRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSK 444
K +L++ ++EE+ E + ++ +++ Q+ E+ KEL + +L + + L++ +A ++
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 445 SKSECTQLHLNLEKEKNLTKDLLNE----LEVVKSRVKELECSESRLEKAELSLKDDLTK 500
+E ++ + L +K +++L+E LE + R ++L+ ++ + L L++ L +
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 501 LKSFTVMLVDERKNMMEKIKQEERKV-------DGLNKNFKVEQGKVMDVTEKLIEE--- 550
++ L E+ KIK+ E ++ + L+K K+ + ++ D+T L EE
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 551 SKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREI 610
+K L KLK++ E + EL +LK EE+ EL + LK++L+G E
Sbjct: 1022 AKNLTKLKNKHESMI-------SELEVRLKKEEKSRQEL----EKLKRKLEGDASDFHEQ 1070
Query: 611 TRGRSRKGSELTCPEDNKIKELTLEIERL-------KKRLQQLEVVEGDLMKTEDEYDQL 663
+ +EL K +EL + RL L+++ +EG + +++ D
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 664 EQKFRTEQDKANFLSQQLEEIKHQI---AKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL 720
+ + L ++LE +K ++ + A ++ +E E+ + + ++R
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 721 KAEVQALKEK----IHELMNKEDQLSQLQVDYSVLQQRFMEEENKN-----KNMG---QE 768
+A+VQ +++K + EL + +Q + + + +Q +E+EN + + +G QE
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT-LEKENADLAGELRVLGQAKQE 1249
Query: 769 VLNLTKELELS-KRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRK 826
V + K+LE + R ++ V + ++V+G E E A+ + K
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 133 bits (335), Expect = 9e-31
Identities = 175/813 (21%), Positives = 359/813 (44%), Gaps = 90/813 (11%)
Query: 24 IGNAGEKSLSEDAKKKKK---SNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDL 80
I N E L D KK++ + K + G + R E E K K+ + +E
Sbjct: 1081 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ 1140
Query: 81 IQLLSIME--GELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKS 138
QLL++ E E+Q + + I LK E E+ H E E++ + + KS
Sbjct: 1141 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHM---ETERLELAQKLNENYEEVKS 1197
Query: 139 IGEDVYEKPISELDRLEEKQKETYRRML-----------EQLLLAE---KCHRRTVYELE 184
I ++ K + EL + E +++ R + E+L +A K H+ T+ EL
Sbjct: 1198 ITKE--RKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELR 1255
Query: 185 NEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKE----KENAKRLNKLRDEL 240
+ T + + D + +E + L E+++ KE +E L L ++
Sbjct: 1256 RSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQS 1315
Query: 241 VKLKSFALMLVDERQMHIEQLGLQSQK-VQDLTQK---LREEEEKLKAITSKSKED-RQK 295
S L ++ ++ + + +SQ+ ++ LT++ L+ +E L+ + KE R+
Sbjct: 1316 TTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRET 1375
Query: 296 LLKL-EVDFEHKASRFSQEHEEMNAKLANQ-------ESHNRQLRLKLVGLTQRIEELEE 347
L K+ E + + S +E + K+ ++ +S ++ ++++GL++R++E +
Sbjct: 1376 LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD 1435
Query: 348 TNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCREL 407
K++ K +++LQ L++ L +E + L++ + E+ K E TE + +
Sbjct: 1436 EMKSVAKEKDDLQRLQEV----------LQSESDQLKENIKEIVAKHLE---TEEELKVA 1482
Query: 408 RKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNL----- 462
L+E+E ELR+ + + + +S ++K EA + Q E++ N+
Sbjct: 1483 HCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISE 1542
Query: 463 TKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQE 522
++ +NEL+ K K + + +E L L + L + + +++ E++ M +
Sbjct: 1543 VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEAL 1602
Query: 523 ERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSE 582
+ + D L +N K K+ + EK + K + +E +EK+ + +++ + +
Sbjct: 1603 QIERDQLKENTKEIVAKMKESQEKEYQFLK--MTAVNETQEKMCEIEHLKEQFETQKLNL 1660
Query: 583 EEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLE-IERLKK 641
E +E +L + L+ + V +E R R E E +++KE E I R +
Sbjct: 1661 ENIETENIRLTQILHENLEEMRSVTKE--RDDLRSVEETLKVERDQLKENLRETITRDLE 1718
Query: 642 RLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEV-V 700
+ ++L++V L + ++ D+L +K N +S ++++H N A++ ++ +
Sbjct: 1719 KQEELKIVHMHLKEHQETIDKLRG---IVSEKTNEISNMQKDLEHS---NDALKAQDLKI 1772
Query: 701 SQEAELRHRFRLEEAKS-------------------RDLKAEVQALKEKIHELMNKEDQL 741
+E + H E+ ++ +DL+ L+EKI EL E QL
Sbjct: 1773 QEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQL 1832
Query: 742 SQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTK 774
L+ D + Q++ E E K + + L L+K
Sbjct: 1833 ITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSK 1865
Score = 125 bits (313), Expect = 3e-28
Identities = 196/865 (22%), Positives = 375/865 (43%), Gaps = 123/865 (14%)
Query: 58 HLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGS 117
HLK E + ++S+ +I + + + +E++ + + ++ P V E
Sbjct: 1243 HLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEV---- 1298
Query: 118 AEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHR 177
+E ++ + L L E+S +D E++RL +K + + L E+ +
Sbjct: 1299 SETQETMNELE----LLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL 1354
Query: 178 RTVYELENEKH------------KHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARK 225
+T+ E KH K + +K + N+ E++ E K + E E+ K
Sbjct: 1355 KTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQF----K 1410
Query: 226 EKENA------------KRLNKLRDEL---VKLKSFALMLVDERQMHIEQLGLQSQKVQD 270
K++A KRL + DE+ K K L + Q +QL + +++
Sbjct: 1411 PKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQL---KENIKE 1467
Query: 271 LTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFS---QEHEEMNAKLAN--QE 325
+ K E EE+LK KE + + +L V+ K + S ++ E +N KL N QE
Sbjct: 1468 IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE 1527
Query: 326 SHNR--QLRLKLVGLTQ-RIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVEN 382
+ + Q +K + Q ++ EL++ ++ + + LQ + K+ + E++
Sbjct: 1528 IYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQI 1587
Query: 383 LRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLE------VEKLQKRMSELE 436
+ K EM+ E + Q +E K++ + S+E + V + Q++M E+E
Sbjct: 1588 MIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIE 1647
Query: 437 KLEEAFSKSKSECTQLHLNLEKEK-NLTKDLLNELEVVKSRVKE---LECSESRLEKAEL 492
L+E F K N+E E LT+ L LE ++S KE L E L+
Sbjct: 1648 HLKEQFETQKLNLE----NIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERD 1703
Query: 493 SLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESK 552
LK++L + + + +E K + +K+ + +D L + ++ ++ +K +E S
Sbjct: 1704 QLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNM-QKDLEHSN 1762
Query: 553 KLLK---LKSEMEEKVYNL-TRERDELIGKLKS-EEEKSSELSCSVDLLKKRLDGIEEVE 607
LK LK + E ++ ++ +E+ E I KL+ EK+ +LS ++ K + +++
Sbjct: 1763 DALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLS---NMQKDLENSNAKLQ 1819
Query: 608 REITRGRSRKGSELTCPED-NKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQK 666
+I ++ + +T +D N+ ++ E+E+LKK+++ + L K E E L QK
Sbjct: 1820 EKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLT---LSKLEIENLNLAQK 1876
Query: 667 FRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL------ 720
L + LEE+K + + + + E + + + L+E K+RDL
Sbjct: 1877 ----------LHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQEL 1926
Query: 721 ----------KAEVQALKEKIHELMNKEDQLSQLQVDY----SVLQQRFMEEENK----- 761
K V L+EKI E K Q+S +Q D LQ++ E + K
Sbjct: 1927 KTARMLSKEHKETVDKLREKISE---KTIQISDIQKDLDKSKDELQKKIQELQKKELQLL 1983
Query: 762 ----NKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEE 817
+ NM + +N E+E K+ A S+ RM + +T ++ A+E
Sbjct: 1984 RVKEDVNMSHKKIN---EMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE 2040
Query: 818 ETPAVFIRKSFQ-EENHIMSNLRQV 841
I++S + E + ++ LR++
Sbjct: 2041 RDELRRIKESLKMERDQFIATLREM 2065
Score = 115 bits (289), Expect = 2e-25
Identities = 185/875 (21%), Positives = 384/875 (43%), Gaps = 148/875 (16%)
Query: 71 KSLELSKEDLIQLLSIMEGEL-QAREDVIHML-KTEKTKPEVLEAHYGSAEPEKVLRVLH 128
KS+ K+DL +L +++ E Q +E++ ++ K +T+ E+ AH E E+ + L
Sbjct: 1438 KSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELR 1497
Query: 129 RD---------AILAQEKSIGE-------DVYEKP----ISELDRLEEKQKETYRRMLEQ 168
+ I Q ++I + ++YEK I ++ ++EK E L+Q
Sbjct: 1498 VNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNE-----LKQ 1552
Query: 169 LLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKE-- 226
K + +E++ + T+ + +S + ++ +E+E +K++ E A Q ++
Sbjct: 1553 FKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQE---ALQIERDQL 1609
Query: 227 KENAKRL-NKLRDELVK----LKSFALMLVDERQMHIEQLGLQ--SQKVQ---------D 270
KEN K + K+++ K LK A+ E+ IE L Q +QK+
Sbjct: 1610 KENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIR 1669
Query: 271 LTQKLREEEEKLKAITSKSKEDR--QKLLKLEVD-----FEHKASRFSQEHEEMNAKLAN 323
LTQ L E E+++++T + + R ++ LK+E D +R ++ EE+ +
Sbjct: 1670 LTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMH 1729
Query: 324 QESHNRQLRLKLVGL-TQRIEELEETNKNLQKAEEELQ----ELRDKIAKGECGNSSLMA 378
+ H + KL G+ +++ E+ K+L+ + + L+ ++++++
Sbjct: 1730 LKEHQETID-KLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQE 1788
Query: 379 EVENLRKRVLEMEGKDEEITKT-ESQCRELRKKLQE---EEHHSKELRLEVEKLQKRMSE 434
++ LR V E K + K E+ +L++K+QE EH L+ +V + QK++SE
Sbjct: 1789 TIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSE 1848
Query: 435 LEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKE---LECSESRLEKAE 491
+E+L++ ++L + + NL + L LE +KS +KE L E L+
Sbjct: 1849 MEQLKKQIKDQSLTLSKLEI---ENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER 1905
Query: 492 LSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEES 551
LK+ L + K+ + + E K K+ + VD L + + ++ D+ + L +
Sbjct: 1906 DQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSK 1965
Query: 552 KKLLKLKSEMEEKVYNLTRERDEL---------IGKLKSEEEKSSELSCSV-----DLLK 597
+L K E+++K L R ++++ + +LK + E + SV L K
Sbjct: 1966 DELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTK 2025
Query: 598 KRLDGIEEV-----EREITR---------------------GRSRKGSELTCPEDNKIKE 631
K + +EE+ ER+ R R R+ ++ PE + +
Sbjct: 2026 KLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVK-PEKRLLSD 2084
Query: 632 LTLEI-ERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIA- 689
+ E L+++ +++ + + +D Y+ L + + + F + +K ++
Sbjct: 2085 GQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSL 2144
Query: 690 ---KNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQV 746
+ K IEK +Q + F K + + + V +KE+ HE +NK
Sbjct: 2145 PYLQTKHIEKLFTANQRCSM--EFHRIMKKLKYVLSYVTKIKEEQHESINK--------- 2193
Query: 747 DYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQ 806
+ F++E K K + ++ +L ++ ++ R R L+ + N +
Sbjct: 2194 ----FEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQN-----------MDLH 2238
Query: 807 TDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQV 841
+ + + +E E P+ I+ FQ+ ++SN +++
Sbjct: 2239 IEEILKDFSESEFPS--IKTEFQQ---VLSNRKEM 2268
Score = 108 bits (270), Expect = 3e-23
Identities = 188/896 (20%), Positives = 390/896 (43%), Gaps = 117/896 (13%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMAS---GTVKRHLKTSGECERK-TKKSLELSKEDLIQLL 84
+K + D +K+ +S E + S G V + L + E E K T EL+KE
Sbjct: 679 KKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKE------ 732
Query: 85 SIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVY 144
+E RE+VI + + + EV + + L + I +++ + +V
Sbjct: 733 --VEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHI-----ITSEKDKLFSEVV 785
Query: 145 EKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNK-------- 196
K LEE K + L + ++ T E +N K H D+ K
Sbjct: 786 HKESRVQGLLEEIGKTK-----DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN 840
Query: 197 ---SDDFTNLLEQERERLKKL--LEQEKAYQAR----KEKENAKRLNK---LRDELVKLK 244
+ + NL ++ ++ L L+ E +Y+ + K +E +RLN+ L+++L
Sbjct: 841 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
Query: 245 SFALMLVDERQMHIEQLGLQSQKVQDLTQK---LREEEEKLKAITSKSKEDRQKLLKLEV 301
S + E+ + E+L ++V+ LTQ+ L++ +E L+ + K D + + +
Sbjct: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI 960
Query: 302 DFEHK---ASRFSQEHEE----MNAKLANQESHNRQL-----------RLKLVGLTQRIE 343
D + + A ++H+E + +K++ + S N + + K+VG+ ++ +
Sbjct: 961 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK-Q 1019
Query: 344 ELEETNKNLQKAE---EELQELRDKI-----AKGECGN--SSLMAEVENLR---KRVLEM 390
+LE N A+ E+ E + KI K E S++AE E L+ K +EM
Sbjct: 1020 DLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM 1079
Query: 391 EGKD-EEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSEC 449
++ EE+ + ++ ++ + +E++H+ + E+ + R++E+E+ + S+ E
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 450 TQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLV 509
Q LN+++E + + +NE+E +K+ +K E + +E L L L + +
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT 1199
Query: 510 DERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEK-------LIEESKKLLKLKSEME 562
ERK + E K E + D L + + + E+ L E + + +L+ +
Sbjct: 1200 KERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVS 1259
Query: 563 EKVYNLTRERDELIGKLKSEEE-----KSSELSCSVDLLKKRLDGIEEVEREITRGRSRK 617
EK + +D K +EE + EL +V + + + + E+E + ++
Sbjct: 1260 EKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKD 1319
Query: 618 GSELTCPE------DNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQ 671
+ L E + K +E EI+ L K L+ ++ L E ++DQL++ R +
Sbjct: 1320 STTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEAL---EVKHDQLKEHIR--E 1374
Query: 672 DKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKI 731
A Q ++ + K K E ++VS+ +F+ +++ ++ E+ L +++
Sbjct: 1375 TLAKIQESQSKQEQSLNMKEKDNETTKIVSE----MEQFKPKDSALLRIEIEMLGLSKRL 1430
Query: 732 HELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEV----LNLTKELELSKRYSRALR 787
E ++ +++ + D LQ+ E ++ K +E+ L +EL+++ +
Sbjct: 1431 QESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQE 1490
Query: 788 PSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQE--ENHIMSNLRQV 841
++N R V++ T + T EA ++ ++ QE E N++Q+
Sbjct: 1491 ETINELR-VNLSEKETEISTIQKQLEAINDK-----LQNKIQEIYEKEEQFNIKQI 1540
Score = 97.4 bits (241), Expect = 7e-20
Identities = 155/774 (20%), Positives = 340/774 (43%), Gaps = 86/774 (11%)
Query: 38 KKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDV 97
K+ K +RK D + L+ + + ++++ +++ ++ ++ + E LQ D
Sbjct: 1551 KQFKEHRKAKDSALQSIESKMLELTNRLQ-ESQEEIQIMIKEKEEMKRVQEA-LQIERDQ 1608
Query: 98 IHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEK 157
+ E TK V + EK + L A+ ++ + E + K E +L +
Sbjct: 1609 LK----ENTKEIVAKM---KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLE 1661
Query: 158 QKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQ 217
ET L Q+L R+V + ++ + + D L E RE + + LE+
Sbjct: 1662 NIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERD--QLKENLRETITRDLEK 1719
Query: 218 EKAYQA--RKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQ-- 273
++ + KE+ + ++KLR + + + + + + + L Q K+Q+ +
Sbjct: 1720 QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIA 1779
Query: 274 --KLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNA---KLANQESHN 328
L+E++E + + E KL ++ D E+ ++ ++ +E+ A +L +
Sbjct: 1780 HMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDV 1839
Query: 329 RQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRK--- 385
+ + K+ + Q +++++ + L K E E L K+ + S+M E +NLR+
Sbjct: 1840 NETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEE 1899
Query: 386 -RVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSE----LEKLEE 440
LE + E + +T+++ E++++L+ SKE + V+KL++++SE + +++
Sbjct: 1900 TLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQK 1959
Query: 441 AFSKSKSECTQLHLNLEKEK----------NLTKDLLNELEVVKSR--VKELECSESRLE 488
KSK E + L+K++ N++ +NE+E +K + + L R++
Sbjct: 1960 DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMD 2019
Query: 489 KAELSLK--DDLTKLKSFTVMLVDERKNMMEKIKQEERKV----------DGLNKNFKVE 536
+L+ K + L +++ DE + + E +K E + D N K E
Sbjct: 2020 NFQLTKKLHESLEEIR-IVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPE 2078
Query: 537 QGKVMD----VTEKLIEES---KKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSEL 589
+ + D +TE L E+ K+LLK SEM++ L R +L +++ ++E S +
Sbjct: 2079 KRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRV 2138
Query: 590 SCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVV 649
++ L + IE++ R ++E R+ K+ L+ V
Sbjct: 2139 KANLSLPYLQTKHIEKLFTANQR-------------------CSMEFHRIMKK---LKYV 2176
Query: 650 EGDLMKTEDEYDQLEQKFRTE-QDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRH 708
+ K ++E + KF + D+ + L +I+H + ++ + E+ +
Sbjct: 2177 LSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQH-LQQDCDVPSRELRDLKLNQNM 2235
Query: 709 RFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKN 762
+EE ++E ++K + ++++ +++Q ++ L RF E+ KN
Sbjct: 2236 DLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEW--LNTRFDIEKLKN 2287
Score = 86.3 bits (212), Expect = 2e-16
Identities = 122/631 (19%), Positives = 275/631 (43%), Gaps = 85/631 (13%)
Query: 195 NKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDER 254
++SD F+N L+ E +E A + ++ LN LR + D
Sbjct: 467 SESDVFSNTLDTLSE-----IEWNPATKLLNQENIESELNSLRADY-----------DNL 510
Query: 255 QMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEV----DFEHKASRF 310
+ EQL + ++++ L K + + ++ +A+ K+K+D++ L E+ + A +
Sbjct: 511 VLDYEQLRTEKEEME-LKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVY 569
Query: 311 SQEHE-EMNAKLAN-QESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAK 368
+Q+ E E+++K+ +E ++ +L+ +Q++E ++ ++ E+ ++++ +
Sbjct: 570 NQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFD 629
Query: 369 GECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEK- 427
E E LR LE++ K +E+ T Q + Q + K++++++EK
Sbjct: 630 AETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKE 689
Query: 428 LQKRMSELEKLEEAFSKSKSECTQLHLNLE-KEKNLTKDLLNELEVVKS------RVKEL 480
LQ +E+ KL + +L LE K +L K+L E+E ++ + EL
Sbjct: 690 LQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSEL 749
Query: 481 ECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNF---KVEQ 537
+ S +E+ ++D +L ++ E+ + ++ +E +V GL + K +
Sbjct: 750 KSLPSEVERLRKEIQDKSEELH----IITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL 805
Query: 538 GKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLK 597
+ +E + L + E+K + E + + ++ + +++ + S+ LK
Sbjct: 806 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK 865
Query: 598 KRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTE 657
L + +E TR +++E E+E+LK +QLE + L E
Sbjct: 866 TELSYKTQELQEKTR---------------EVQERLNEMEQLK---EQLENRDSTLQTVE 907
Query: 658 DEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKS 717
E + +K + ++ L+Q+ +++K Q+ ++ IE+ ++ S
Sbjct: 908 REKTLITEKLQQTLEEVKTLTQEKDDLK-QLQESLQIERDQLKS---------------- 950
Query: 718 RDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNM-----------G 766
D+ V + +L N + L Q Q + L+ + EE ++N +M
Sbjct: 951 -DIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQ 1009
Query: 767 QEVLNLTKELELSKRYSRALRPSVNGRRMVD 797
Q+++ + K+ +L + ++ L V +++
Sbjct: 1010 QKMVGIDKKQDLEAKNTQTLTADVKDNEIIE 1040
Score = 47.4 bits (111), Expect = 8e-05
Identities = 97/486 (19%), Positives = 187/486 (38%), Gaps = 107/486 (22%)
Query: 102 KTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELD----RLEEK 157
+ EK K +++ + + + R L RD L Q + + K SE + + E +
Sbjct: 2201 EVEKQKELLIKIQHLQQDCDVPSREL-RDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQ 2259
Query: 158 QKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNL-----------LEQ 206
Q + R+ + Q L R + +L+N K D + + ++F N E+
Sbjct: 2260 QVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEE 2319
Query: 207 ERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQ 266
+ K EQ+ K ++ K L+ L D + H+ S+
Sbjct: 2320 RSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVT-----SR 2374
Query: 267 KVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQES 326
Q T+K+RE E L + K++K++ +E E N +A ++
Sbjct: 2375 ATQLTTEKIRELENSLHEAKESAMHKESKIIKMQ-----------KELEVTNDIIAKLQA 2423
Query: 327 HNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKR 386
++ E+NK L+K +E +Q L+DK+A G E+E+L+ +
Sbjct: 2424 -----------------KVHESNKCLEKTKETIQVLQDKVA---LGAKPYKEEIEDLKMK 2463
Query: 387 VLEMEGK--------DEEITKTESQ-------CRELRKKLQEEE---------------- 415
+++++ + ++EI+ T++ R LR+ L+ +
Sbjct: 2464 LVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQP 2523
Query: 416 --------------HHSKELRLEVE--KLQKRMSELEKLEEAFSKSKSECTQLHLNLEKE 459
++K L L+ E +L+K +S+L++ E K K+E + +L E
Sbjct: 2524 SNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNE 2583
Query: 460 KNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKI 519
K E + + K++ C S + +K K T ER N+ + +
Sbjct: 2584 VKTWK----ERTLKREAHKQVTCENS---PKSPKVTGTASKKKQITPSQCKER-NLQDPV 2635
Query: 520 KQEERK 525
+E K
Sbjct: 2636 PKESPK 2641
Score = 45.8 bits (107), Expect = 2e-04
Identities = 80/381 (20%), Positives = 165/381 (43%), Gaps = 47/381 (12%)
Query: 394 DEEITKT-ESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQL 452
DE + K + +L+K+L+E ++ +E ++L + + E + L++ ++ T++
Sbjct: 341 DEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRM 400
Query: 453 HLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDER 512
+ + L + E+ R + + ++ K + S D + T +
Sbjct: 401 LVT-------SSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIP--TNITTKTH 451
Query: 513 KNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRER 572
K + +++ + V + F +D ++ L + +E ++ +L +
Sbjct: 452 KLSINLLREIDESVCSESDVF----SNTLDTLSEIEWNPATKLLNQENIESELNSLRADY 507
Query: 573 DELIGKLKSEEEKSSELSCSVDLLKKR-LDGIEEVEREITRGRSRKGSELTCPEDNKIKE 631
D L+ L E+ ++ + + L +K LD E +ER +++K E+ +
Sbjct: 508 DNLV--LDYEQLRTEKEEMELKLKEKNDLDEFEALER-----KTKKDQEM---------Q 551
Query: 632 LTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFL-----SQQLEEIKH 686
L EI LK ++ EV DL E+E + R ++D+ L SQ+LE IK
Sbjct: 552 LIHEISNLKNLVKHAEVYNQDL---ENELSSKVELLREKEDQIKKLQEYIDSQKLENIKM 608
Query: 687 QIAKN-KAIEKGEVVSQEAELRHRFRLE-EAKSRDLKAEVQALKEKIHEL------MNKE 738
++ + ++IE + + Q L+ + +S L++E LKEK+ EL M +
Sbjct: 609 DLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMEND 668
Query: 739 DQLSQLQVDYSVLQQRFMEEE 759
QL Q Q++ Q +E+E
Sbjct: 669 IQLYQSQLEAKKKMQVDLEKE 689
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 132 bits (331), Expect = 3e-30
Identities = 192/901 (21%), Positives = 387/901 (42%), Gaps = 117/901 (12%)
Query: 34 EDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQA 93
E+ ++K + +E +++A ++ + E E + + L K++L ++L +E ++
Sbjct: 876 EEMERKHQQLLEEKNILAE-QLQAETELFAEAE-EMRARLAAKKQELEEILHDLESRVEE 933
Query: 94 REDVIHMLKTEKTK--------PEVLEAHYGSAEP----------------EKVLRVLHR 129
E+ +L+ EK K E L+ G+ + E++L + +
Sbjct: 934 EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ 993
Query: 130 DAILAQEKSIGEDVYEKPISELDRLEEKQKETYR-RMLEQLLLAE-----KCHRRTVYEL 183
++ +EK + ED + S+L EEK K + R +++++++ K +T EL
Sbjct: 994 NSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053
Query: 184 ENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKL 243
E K K D T L+ + L+ +++ K A+KE+E L + DE +
Sbjct: 1054 EKAK-------RKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH- 1105
Query: 244 KSFALMLVDERQMHIEQL-------GLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKL 296
K+ AL +V E Q I +L K + + L EE E LK + +
Sbjct: 1106 KNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQ 1165
Query: 297 LKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLK----LVGLTQRIEELEETNKNL 352
+L E + + + EE + N E+ + +R + L L++++E+ + NL
Sbjct: 1166 QELRTKREQEVAELKKALEE---ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222
Query: 353 QKAEEELQELRDKIAKGECGNSSLMAEVENLRKR----VLEMEGKDEEITKTESQCRELR 408
+K ++ L+ ++A + AE E+ RK+ V E+ K E + + E
Sbjct: 1223 EKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA 1282
Query: 409 KKLQEEEHHSKELRLEVEK-----------LQKRMSELEKLEEAFSKSKSECTQLHLNLE 457
KLQ E + L E EK L+ ++ + ++L + ++ K + LE
Sbjct: 1283 SKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLE 1342
Query: 458 KEKN-LTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSF---TVMLVDERK 513
+EKN L + E E K+ K++ +S+L + + DDL ++S L+ + +
Sbjct: 1343 EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE 1402
Query: 514 NMMEKIKQEERKVDGLNKNFKVEQGKVMDVT----------EKLIEESKKLLKLKSEMEE 563
+ ++++++ D L K Q ++ D+T L ++ KK +L +E +
Sbjct: 1403 ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS 1462
Query: 564 KVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTC 623
ERD + + +E K+ L+ + L++ L+ EE ER+ + R+ ++
Sbjct: 1463 ISARYAEERDRAEAEAREKETKALSLARA---LEEALEAKEEFERQNKQLRADMEDLMSS 1519
Query: 624 PEDNKIKELTLEIERLKKRLQ--------QLEVVEGDLMKTEDEYDQLEQKFRT------ 669
+D + + E+E+ K+ L+ QLE +E +L TED +LE +
Sbjct: 1520 KDD--VGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE 1577
Query: 670 ---------EQDKANFLSQQLEEIKHQI---AKNKAIEKGEVVSQEAELRHRFRLEEAKS 717
++K L +Q+ E++ ++ K +A+ E +L+ EA +
Sbjct: 1578 RDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN 1637
Query: 718 RDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELE 777
+ ++ L++ ++ + + +L + + + + E E K K++ E+L L +EL
Sbjct: 1638 KARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELA 1697
Query: 778 LSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSN 837
S+ RA R + R + +T++ A+ E E + + +EE M
Sbjct: 1698 SSE---RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMEL 1754
Query: 838 L 838
L
Sbjct: 1755 L 1755
Score = 130 bits (327), Expect = 8e-30
Identities = 188/811 (23%), Positives = 375/811 (46%), Gaps = 111/811 (13%)
Query: 88 EGELQAREDVIHMLKTEKTKPE------------VLE-----AHYGSAEPEKVLRVLHRD 130
E ELQA+++ + +K ++TK E +LE A AE E
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 131 AILAQEKSIGEDVY---------EKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVY 181
A LA +K E++ E+ +++ + E+K+ + + + LE+ L E+ R+
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ--- 967
Query: 182 ELENEKHKHTDYMNKSDDFTNLLEQERERL---KKLLEQ---EKAYQARKEKENAKRLNK 235
+L+ EK + K ++ LLE + + KKL+E E + Q +E+E AK L K
Sbjct: 968 KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAK 1027
Query: 236 LR----------DELVKLKSFALMLVD--ERQMHIEQLGLQSQ------KVQDLTQKLRE 277
+R +E +K + ++ +R++ E LQ Q ++ +L +L +
Sbjct: 1028 IRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAK 1087
Query: 278 EEEKLKAITSKSKED---RQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLK 334
+EE+L+ ++ ++ + LK+ + + + + ++ E A E R L +
Sbjct: 1088 KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEE 1147
Query: 335 LVGLTQRIEELEETNKNLQ----KAEEELQELRDKIAKGECGNSSLMAEVENLRKR-VLE 389
L L +E+ +T Q K E+E+ EL+ K + E N A+++++R+R
Sbjct: 1148 LEALKTELEDTLDTTAAQQELRTKREQEVAELK-KALEEETKNHE--AQIQDMRQRHATA 1204
Query: 390 MEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSEC 449
+E E++ + + L K Q E +KEL EV+ LQ+ +E E + K ++
Sbjct: 1205 LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRK---KLDAQV 1261
Query: 450 TQLHLNLEKEKNLTKDLL-------NELEVVKSRVKELECSESRLEKAELSLKDDLTKLK 502
+LH + + L +L NEL+ V + ++E E + K SL+ L +
Sbjct: 1262 QELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ 1321
Query: 503 SFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEME 562
++ N+ +I+Q E + KN EQ + + K +E K++L L+S++
Sbjct: 1322 ELLQEETRQKLNLSSRIRQLEEE-----KNSLQEQQEEEEEARKNLE--KQVLALQSQLA 1374
Query: 563 EKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLD--GIEEVEREITRGR-SRKGS 619
+ ++ D+ +G ++S EE +L + L +RL+ + + E T+ R ++
Sbjct: 1375 D----TKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430
Query: 620 ELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDL-MKTEDEYDQLEQKFRTEQDKANFLS 678
+LT D++ +++ +E+ +K+ QL E + + +E D+ E + R ++ KA L+
Sbjct: 1431 DLTVDLDHQ-RQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA 1489
Query: 679 QQLE---EIKHQIAK-NKAI--EKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIH 732
+ LE E K + + NK + + +++S + ++ E R L+ +V+ ++ ++
Sbjct: 1490 RALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE 1549
Query: 733 ELMNK----EDQLSQLQVDYSV--------LQQRFMEEENKNKNMGQEVLNLTKELELSK 780
EL ++ ED +L+V+ LQ R + E K + + ++V L ELE +
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE-DE 1608
Query: 781 RYSRALRPSVNGRRMVDVPVTSTGVQTDAVS 811
R RAL +V ++ +++ + Q +A +
Sbjct: 1609 RKQRAL--AVASKKKMEIDLKDLEAQIEAAN 1637
Score = 127 bits (318), Expect = 8e-29
Identities = 163/721 (22%), Positives = 321/721 (44%), Gaps = 104/721 (14%)
Query: 146 KPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLE 205
KP+ ++ R Q+E + E+LL ++ + ELE + KH + + + L+
Sbjct: 842 KPLLQVTR----QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ 897
Query: 206 QERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDER---QMHIEQLG 262
E E + E+ +A A K++E + L+ L + + + +L +E+ Q HI+ L
Sbjct: 898 AETELFAE-AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE 956
Query: 263 LQSQKVQDLTQKLREEEEKLKAITSKSKED-------RQKLLKLEVDFEHKASRFSQEHE 315
Q + + QKL+ E+ +A K +E+ K +K + E + + S +
Sbjct: 957 EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA 1016
Query: 316 EMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQ----ELRDKIAKGEC 371
E K N + + + L +R+++ E+T + L+KA+ +L +L+D+IA+
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE--- 1073
Query: 372 GNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKR 431
L A+++ L+ L++ K+EE+ L + E H + L++ V +LQ +
Sbjct: 1074 ----LQAQIDELK---LQLAKKEEELQGA------LARGDDETLHKNNALKV-VRELQAQ 1119
Query: 432 MSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAE 491
++EL++ E+ S+++ EK+K +DL ELE +K+ +++ + + ++
Sbjct: 1120 IAELQEDFESEKASRNKA-------EKQK---RDLSEELEALKTELEDTLDTTAAQQELR 1169
Query: 492 LSLKDDLTKLKSFTVMLVDERKN------------------MMEKIKQEERKVDGLNKNF 533
+ ++ +LK L +E KN + E+++Q +R L KN
Sbjct: 1170 TKREQEVAELKK---ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKN- 1225
Query: 534 KVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSV 593
+QG D ++L E K L ++K+E E K L + EL K+ + EL+
Sbjct: 1226 --KQGLETD-NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA 1282
Query: 594 DLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDL 653
L+ LD + + E +KG + + +L E L++ +Q + +
Sbjct: 1283 SKLQNELDNVSTLLEE----AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRI 1338
Query: 654 MKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKA---IEKGEVVSQEAELRHRF 710
+ E+E + L+++ E++ L +Q+ ++ Q+A K + G + S E +
Sbjct: 1339 RQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLL 1398
Query: 711 RLEEAKSRDLKAEVQALKEKIHELMNK-EDQLSQLQVDYSVLQQRFMEEENKNKNMGQEV 769
+ EA S+ L+ + A +K+ + N+ + +L L VD +Q E K K Q
Sbjct: 1399 KDAEALSQRLEEKALAY-DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ-- 1455
Query: 770 LNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQ 829
L +E +S RY+ + D EA E+ET A+ + ++ +
Sbjct: 1456 -LLAEEKSISARYAE---------------------ERDRAEAEAREKETKALSLARALE 1493
Query: 830 E 830
E
Sbjct: 1494 E 1494
Score = 125 bits (314), Expect = 2e-28
Identities = 169/761 (22%), Positives = 321/761 (42%), Gaps = 75/761 (9%)
Query: 59 LKTSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSA 118
L+ E E+ ++ E K DL + L ++ EL+ D + +TK E A A
Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA 1182
Query: 119 EPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLE---EKQKETYRRMLEQLLLAEKC 175
E+ + + Q + + + + + R + EK K+ ++L K
Sbjct: 1183 LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV 1242
Query: 176 HRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKR-LN 234
++ E E+++ K ++ + E +RL+ L EKA + + E +N L
Sbjct: 1243 LQQVKAESEHKRKK----LDAQVQELHAKVSEGDRLRVEL-AEKASKLQNELDNVSTLLE 1297
Query: 235 KLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQ 294
+ + +K A L + Q E L ++++ +L+ ++R+ EE+ ++ + +E+ +
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357
Query: 295 KLLKLEVDFEHKASRFSQEHEEMNAKLANQES---HNRQLRLKLVGLTQRIEE------- 344
LE S+ + ++++ L ES ++L L+QR+EE
Sbjct: 1358 ARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDK 1417
Query: 345 LEETNKNLQKAEEEL-------QELRDKIAKGECGNSSLMAEVENLRKRV------LEME 391
LE+T LQ+ ++L +++ + K + L+AE +++ R E E
Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE 1477
Query: 392 GKDEEITKTESQCRELRKKL---QEEEHHSKELRLEVEKLQ-------KRMSELEKLEEA 441
+++E TK S R L + L +E E +K+LR ++E L K + ELEK + A
Sbjct: 1478 AREKE-TKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536
Query: 442 FSKSKSECTQLHLNLEKEKNLTKDLLNELEV------------VKSRVKELECSESRLEK 489
+ E LE E T+D LEV +++R ++ E + L K
Sbjct: 1537 LEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK 1596
Query: 490 AELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIE 549
L+ +L + + V +K M +K E +++ NK +++I+
Sbjct: 1597 QVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK-----------ARDEVIK 1645
Query: 550 ESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVERE 609
+ +KL + + ++ RDE+ + K E+K L + L++ L E R
Sbjct: 1646 QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRH 1705
Query: 610 ITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRT 669
+ R E+T K L E RL+ R+ QL E +L + + + L +FR
Sbjct: 1706 AEQERDELADEITNSASGK-SALLDEKRRLEARIAQL---EEELEEEQSNMELLNDRFRK 1761
Query: 670 EQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFR-LEEAKSRDLKAEVQALK 728
+ + L+ +L + A+ + ++ Q EL+ + + LE A KA + AL+
Sbjct: 1762 TTLQVDTLNAEL-AAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE 1820
Query: 729 EKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEV 769
KI +L E+QL Q + + + E K K + +V
Sbjct: 1821 AKIGQL---EEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858
Score = 117 bits (292), Expect = 9e-26
Identities = 137/613 (22%), Positives = 293/613 (47%), Gaps = 88/613 (14%)
Query: 219 KAYQARKEKENA-KRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQ---K 274
KA+ ++++ +A K L + +KL+ + V + + Q+ Q +++Q + K
Sbjct: 804 KAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLK 863
Query: 275 LREEEEKLKAITSKSKEDRQKLLK----LEVDFEHKASRFSQEHEEMNAKLANQESHNRQ 330
++E++ K++ + + Q+LL+ L + + F+ E EEM A+LA ++ +
Sbjct: 864 VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA-EAEEMRARLAAKKQELEE 922
Query: 331 LRLKLVGLTQRIEELEETNKNLQ----KAEEELQELRDKIAKGECGNSSLM-------AE 379
+ L L R+EE EE N+ LQ K + +Q+L +++ + E L A+
Sbjct: 923 I---LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAK 979
Query: 380 VENLRKRVLEMEGKDEEITKT----ESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSEL 435
++ + + +L +E ++ + K E + E +L EEE +K L K + +S+L
Sbjct: 980 IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDL 1039
Query: 436 EKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLK 495
E+ + K++ E + L+ E T DL +++ +++++ EL+ +L K E L+
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGE---TTDLQDQIAELQAQIDELKL---QLAKKEEELQ 1093
Query: 496 DDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLL 555
L + T+ + N ++ +++ + ++ L ++F+ E+ ++ + S++L
Sbjct: 1094 GALARGDDETL----HKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELE 1149
Query: 556 KLKSEMEEKV------YNLTRERDELIGKLKS--EEEKSSELSCSVDLLKKRLDGIEEVE 607
LK+E+E+ + L +R++ + +LK EEE + + D+ ++ +EE+
Sbjct: 1150 ALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELS 1209
Query: 608 REITRGRSRKGS-------------ELTCPEDNKIKELTLEIERLKKRL----QQL--EV 648
++ + + K + EL C E ++++ E E +K+L Q+L +V
Sbjct: 1210 EQLEQAKRFKANLEKNKQGLETDNKELAC-EVKVLQQVKAESEHKRKKLDAQVQELHAKV 1268
Query: 649 VEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRH 708
EGD ++ E + K + E D + L ++ E+ + AK+ A S E++L+
Sbjct: 1269 SEGDRLRV--ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA-------SLESQLQD 1319
Query: 709 RFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQE 768
L L+E+ + +N ++ QL+ + + LQ++ EEE KN+ ++
Sbjct: 1320 TQEL--------------LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQ 1365
Query: 769 VLNLTKELELSKR 781
VL L +L +K+
Sbjct: 1366 VLALQSQLADTKK 1378
Score = 106 bits (264), Expect = 2e-22
Identities = 152/736 (20%), Positives = 307/736 (41%), Gaps = 71/736 (9%)
Query: 28 GEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIM 87
G++ E A+K K + D+V T+ + G K SLE +D +LL
Sbjct: 1271 GDRLRVELAEKASKLQNELDNV---STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEE 1327
Query: 88 EGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKP 147
+ I L+ EK + + A +VL + LA K +D
Sbjct: 1328 TRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD----D 1383
Query: 148 ISELDRLEEKQK------ETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFT 201
+ ++ LEE +K E + LE+ LA +T L+ E T ++
Sbjct: 1384 LGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVA 1443
Query: 202 NLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQL 261
+ LE+++++ +LL +EK+ AR +E + + R++ K S A L + +
Sbjct: 1444 SNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEA----- 1498
Query: 262 GLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKL 321
++ + ++LR + E L + ++ +L K + E + + EE+ +L
Sbjct: 1499 ---KEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555
Query: 322 ANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVE 381
E +L + + + + E ++LQ +E+ +E + + K L AE+E
Sbjct: 1556 QATEDAKLRLEVNMQAMKAQFE------RDLQTRDEQNEEKKRLLIKQV---RELEAELE 1606
Query: 382 NLRK-RVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEK-LE 439
+ RK R L + K K E ++L +++ E+ ++ KLQ +M + ++ LE
Sbjct: 1607 DERKQRALAVASKK----KMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELE 1662
Query: 440 EAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLT 499
EA + Q + E EK L K L E+ ++ + E + E+ L D++T
Sbjct: 1663 EARASRDEIFAQ---SKESEKKL-KSLEAEILQLQEELASSERARRHAEQERDELADEIT 1718
Query: 500 KLKSFTVMLVDERKNMM-------EKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESK 552
S L+DE++ + E++++E+ ++ LN F+ +V + +L E
Sbjct: 1719 NSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERS 1778
Query: 553 KLLKLKSEMEEKVYNLTRERDELIGKLKS-EEEKSSELSCSVDLLKKRLDGIEEVEREIT 611
K + ++ L R+ EL KL+ E S+ ++ L+ ++ +EE +
Sbjct: 1779 AAQKSDNARQQ----LERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 612 RGRSRKGSELTCPEDNKIKELTLEIE------------------RLKKRLQQLEVVEGDL 653
+ R+ ++L + K+KE+ +++E R+K+ +QLE E +
Sbjct: 1835 KERAA-ANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEA 1893
Query: 654 MKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLE 713
+ +L+++ + LS+++ +K+++ + I S +L
Sbjct: 1894 TRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASL 1953
Query: 714 EAKSRDLKAEVQALKE 729
E D +++ + E
Sbjct: 1954 ELSDDDTESKTSDVNE 1969
Score = 103 bits (257), Expect = 1e-21
Identities = 140/640 (21%), Positives = 267/640 (41%), Gaps = 89/640 (13%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIME 88
EK+L+ D +K K+ +++ + + + + E+K KK +L E+ E
Sbjct: 1410 EKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAE 1469
Query: 89 ----GELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVY 144
E +ARE L + E LEA K LR D +++ + +G++V+
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED-LMSSKDDVGKNVH 1528
Query: 145 EKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLL 204
E + + R E+Q E R LE+L ++ +L E + D
Sbjct: 1529 E--LEKSKRALEQQVEEMRTQLEEL--EDELQATEDAKLRLEVNMQAMKAQFERDLQTRD 1584
Query: 205 EQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQ 264
EQ E+ + L++Q + +A E E +R AL + +++M I+ L+
Sbjct: 1585 EQNEEKKRLLIKQVRELEAELEDERKQR--------------ALAVASKKKMEIDLKDLE 1630
Query: 265 SQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQ 324
+Q + K R+E K +D Q+ L+ E +ASR +E+ A+
Sbjct: 1631 AQI--EAANKARDEVIKQLRKLQAQMKDYQRELE-----EARASR-----DEIFAQSKES 1678
Query: 325 ESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLR 384
E + L +++ L EEL + + + AE+E EL D+I G S+L+ E L
Sbjct: 1679 EKKLKSLEAEILQLQ---EELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLE 1735
Query: 385 KRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSK 444
R+ ++E E+L++ S +E L + F K
Sbjct: 1736 ARIAQLE----------------------------------EELEEEQSNMELLNDRFRK 1761
Query: 445 SKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSF 504
+ + L+ L E++ + N + ++ + KEL+ LE A S K K+
Sbjct: 1762 TTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKS------KFKAT 1815
Query: 505 TVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEK 564
L + + E+++QE ++ NK + + K+ ++ ++ +E + + K +ME+
Sbjct: 1816 ISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEK- 1874
Query: 565 VYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEE----VEREIT--RGRSRKG 618
+L +L+ EE+++ + S L++ LD E + RE++ + R R+G
Sbjct: 1875 ---ANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRG 1931
Query: 619 SELTCPEDNK-IKELTLEIERLKKRLQQLEVVEGDLMKTE 657
++ ++L LE L+ E D+ +T+
Sbjct: 1932 GPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQ 1971
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 130 bits (328), Expect = 6e-30
Identities = 166/732 (22%), Positives = 335/732 (45%), Gaps = 81/732 (11%)
Query: 26 NAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLS 85
N + + D KKKK +N + SG S E E+K Q
Sbjct: 75 NPSVGTAASDTKKKKINNGTNPETTTSGGCH-----SPEDEQKASH----------QHQE 119
Query: 86 IMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKS---IGED 142
+ EL+A+ I +L +KT E+ A Y S K L RD I S GE
Sbjct: 120 ALRRELEAQVHTIRILTCQKT--ELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGE- 176
Query: 143 VYEKPISELDRLEEKQKETYRRMLEQLL-----LAEKCHRRTVY--ELENEKHKHTDYMN 195
E+ +S + QK+ R +E+L L+ + +R T+ EL+ + K + +
Sbjct: 177 -LEQALSAV----ATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQ 231
Query: 196 KSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDER- 254
+ + ++ + LK+ LE+ K +++ + + L EL + + V+E
Sbjct: 232 LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQ--AEADHLGKELQSVSAKLQAQVEENE 289
Query: 255 ------QMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKAS 308
Q E++ Q +K+Q+ +K++E+EEK++ K +E +K+ + E K
Sbjct: 290 LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEE 349
Query: 309 RFSQEHE---EMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDK 365
+ ++ E E K+ QE + K+ + + E EE + L++ E +++R++
Sbjct: 350 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ 409
Query: 366 IAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKL--QEEEHHSKELRL 423
K + + E E +++ +M ++E+I + E + RE KK+ QEE+ H +E
Sbjct: 410 EEKRQ--EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR 467
Query: 424 EVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECS 483
E EK Q++ E+ + EE + + Q E+E+ + K E +V + K E
Sbjct: 468 EEEKRQEQ-EEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRK---QEEKVWRQEEKIREQE 523
Query: 484 ESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDV 543
E E+ E + + + + +E+ + EKI +EE++ + +K ++ E
Sbjct: 524 EKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQE------- 576
Query: 544 TEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGI 603
EK+ E+ +K+ + EEK+ +R E K+ +EEK E + ++++ + I
Sbjct: 577 -EKIREQEEKVWR----QEEKIREQEEKRQEQEEKMWKQEEKIRE---QEEKIQEQEEKI 628
Query: 604 EEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQL 663
E E +I R+ E+T ++ K+ E + E++ ++ ++++ E + + E++ +
Sbjct: 629 REQEEKI-----REQEEMTQEQEEKMGE---QEEKMCEQEEKMQEQEETMWRQEEKIREQ 680
Query: 664 EQKFRTEQDKANFLSQQLEEIKHQI--AKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLK 721
E+K R +++K + ++E + ++ + K E+ E + ++ E + R +E K + +
Sbjct: 681 EKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE---KMRRQEEKMWEQE 737
Query: 722 AEVQALKEKIHE 733
++ +EK+ E
Sbjct: 738 VRLRQQEEKMQE 749
Score = 64.3 bits (155), Expect = 7e-10
Identities = 86/396 (21%), Positives = 176/396 (44%), Gaps = 67/396 (16%)
Query: 389 EMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRM-------SELEKLEEA 441
E+E + I Q EL+ L +H K+L E L R+ ELE+ A
Sbjct: 124 ELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSA 183
Query: 442 FSKSKSECTQLHLNLEKEKN-----LTKDLLNELEVVKSRVK---ELECSESRLEKAELS 493
+ K + + L KE++ L ++ + + E+ + K +L+ ES + +L+
Sbjct: 184 VATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLN 243
Query: 494 LKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKK 553
+K+ KL ER ++ +Q + + D L K + K+ + +EE++
Sbjct: 244 VKELKRKL---------ERAKLLLPQQQLQAEADHLGKELQSVSAKL----QAQVEENEL 290
Query: 554 LLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRG 613
+L + EEK++ + E K++ +EEK ++++ + I E E ++
Sbjct: 291 WNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEK----------IREQEEKIREQEEKM--- 337
Query: 614 RSRKGSELTCPEDNKIK---ELTLEIERLKKRLQQLEVVEGDLMKTEDEYD-QLEQKFRT 669
R+ E+ ++ K++ E+ E E +R +++ + + M+ ++E + E+K R
Sbjct: 338 --RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR- 394
Query: 670 EQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKE 729
+LEE H+ + K E+ E +E ++R E+ K ++ +A++ +E
Sbjct: 395 ----------ELEEKMHE--QEKIREQEEKRQEEEKIR-----EQEKRQEQEAKMWRQEE 437
Query: 730 KIHELMNK--EDQLSQLQVDYSVLQQRFMEEENKNK 763
KI E K E + + + + +Q + EE K +
Sbjct: 438 KIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ 473
Score = 49.3 bits (116), Expect = 2e-05
Identities = 56/312 (17%), Positives = 144/312 (46%), Gaps = 22/312 (7%)
Query: 466 LLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERK 525
L ELE ++ L C ++ L+ A + + +L+ L+ + + + E+
Sbjct: 121 LRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQA 180
Query: 526 VDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEK 585
+ + K + ++T++ S +L + EE L + +L KL+ E +
Sbjct: 181 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE----LKEKNAKLQEKLQLVESE 236
Query: 586 SSELSCSVDLLKKRLDGIEEV--EREITRGRSRKGSELTCP--------EDNKI--KELT 633
SE+ +V LK++L+ + + ++++ G EL E+N++ +
Sbjct: 237 KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQ 296
Query: 634 LEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKA 693
+ E++ ++ ++++ E + + E++ + E+K R +++K + + E + ++ + +
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 356
Query: 694 I--EKGEVVSQEAEL----RHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVD 747
+ EK E + ++ E+ + R +E + + +++ L+EK+HE +Q + Q +
Sbjct: 357 MMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE 416
Query: 748 YSVLQQRFMEEE 759
+ +Q +E+
Sbjct: 417 EKIREQEKRQEQ 428
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 127 bits (320), Expect = 5e-29
Identities = 176/821 (21%), Positives = 365/821 (44%), Gaps = 99/821 (12%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLS-IM 87
++ LS + K ED V G + L+ S K +E K +L+ + S
Sbjct: 90 QQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQS---HINYVKEIENLKNELMAVRSKYS 146
Query: 88 EGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVL-------RVLHRDAILAQEKSIG 140
E + ++ + + T+ E L+ S + K L R + IL +K +
Sbjct: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
Query: 141 EDVYEKP--ISELDRLEEKQKETYRRML----EQLLLAEKCHRRTVYEL----ENEKHKH 190
EK +++L + E + Y++ + E+LL + H+ V EL E +H
Sbjct: 207 ATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEH 266
Query: 191 TDYMNKSDDFTNLLEQERERLKKLLEQE---KAYQARKEKENAKRLNKLRDELVKLKSFA 247
+NK ++ L ++ E +K ++++ + RK NA + N++ L++ +F
Sbjct: 267 EAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFV 326
Query: 248 LMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKA 307
+V+E+ H+E L+E E + + + LKLE+D +H
Sbjct: 327 EQVVNEKVKHLEDT-------------LKELESQHSILKDEVTYMNNLKLKLEMDAQHIK 373
Query: 308 SRFSQEHEEMNAK-----LANQESH--NRQLRLKLVGLTQRI-EELEETNKNLQKAEE-- 357
F E E++ K LA +E +L+ +L GL ++ +E+ N+ +Q +E
Sbjct: 374 DEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQH 433
Query: 358 --ELQELRDK-IAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEE 414
E+ EL + ++ E +LM E++ L+++ ++ + +E RE+ + LQ E
Sbjct: 434 QKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTE 493
Query: 415 EHHSK-ELRLEVEKL-QKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEV 472
S ++ E E + Q++ S++ +L++ + +E L + + + + LL++ E+
Sbjct: 494 LGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQEL 553
Query: 473 V---KSRVKELECSESRLEKAELSLKDDLTK-LKSFTVMLVDERKNMMEKIKQEERKVDG 528
V ++ +K L+ ++ + LS +D + K L+ L +E+ + + K+K ++D
Sbjct: 554 VPELENTIKNLQ-EKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDN 612
Query: 529 LNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSE 588
+K + E+ ++++ +K+ ++ ++ SE+E+KV LT +E + + ++K +
Sbjct: 613 FHKKCEREERLILELGKKV----EQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEK 668
Query: 589 LSCSVDLLKKRLDGIEEVEREITRGRSRKGSE-----------LTCPEDNKIKELTLEIE 637
L + +L + + + + + ++ SE L+ ED +KE I
Sbjct: 669 LMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKE---HIT 725
Query: 638 RLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKG 697
+L+K+L QL V E D + E +Q+ QK + FL + E+ + +
Sbjct: 726 QLEKKL-QLMVEEQDNLNKLLENEQV-QKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVL 783
Query: 698 EVVSQ------EAELRHRFRLEEAKSRDLKAEVQALK-------EKIHELMNKEDQ---- 740
+ V + E + F+ +E K +L+ E++ L+ E++ L+ +Q
Sbjct: 784 QAVGESLAKINEEKCNLAFQRDE-KVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVL 842
Query: 741 ----LSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELE 777
L ++Q + LQ +E +N N+ E NL ++E
Sbjct: 843 LRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVE 883
Score = 103 bits (258), Expect = 8e-22
Identities = 175/807 (21%), Positives = 346/807 (42%), Gaps = 109/807 (13%)
Query: 92 QAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISEL 151
Q E V+ + K K E E+ E + +LR ++ +L + K + E EK +
Sbjct: 803 QRDEKVLELEKEIKCLQE--ESVVQCEELKSLLRDYEQEKVLLR-KELEEIQSEKEALQS 859
Query: 152 DRLEEKQKETYRRMLEQLLLA---EKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQE- 207
D LE K R+ Q LL E + E+ NEK K ++ + ++ LLEQ+
Sbjct: 860 DLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKC--FIKEHENLKPLLEQKE 917
Query: 208 -RERLKKLLE----------------------QEKAYQARKE-KENAKRLNKLRDELVKL 243
R+R +L+ +EK KE KE +++NK++ VK
Sbjct: 918 LRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKA 977
Query: 244 KSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDF 303
K ++ ++Q V++ + LR E+++L A + + L +++
Sbjct: 978 KK-----------ELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEY 1026
Query: 304 EHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELR 363
E ++ + E E N E RQLR T + E + N++L E LQ
Sbjct: 1027 EKQSEQLDVEKERANNFEHRIEDLTRQLR----NSTLQCETINSDNEDLLARIETLQSNA 1082
Query: 364 D--KIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKEL 421
++ E + M + E L L+ E K +E T ++ EL+ +LQ+E+
Sbjct: 1083 KLLEVQILEVQRAKAMVDKE-LEAEKLQKEQKIKEHATTVNELEELQVQLQKEK------ 1135
Query: 422 RLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELE 481
++LQK M ELE ++ K + T +++ + + L K+L +L +++++LE
Sbjct: 1136 ----KQLQKTMQELELVK----KDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE 1187
Query: 482 CSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVM 541
++ + +L++++T L+S +V +E+ ++++ + +K ++ K
Sbjct: 1188 QEIKIQKQKQETLQEEITSLQS-SVQQYEEKNTKIKQLLVKTKK--------ELADSKQA 1238
Query: 542 DVTEKLIEESKKLLKLKSEMEEKVY-----NLTRERDELIGKLKSEEEKSSELSCSVDLL 596
+ +++ S K S+ + +VY +T E+ ++ LK+ E+ ++
Sbjct: 1239 ETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQR---TLSAY 1295
Query: 597 KKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKT 656
++R+ ++E R ++ SE E K++ + ++ K + Q E EG K
Sbjct: 1296 QQRVTALQEECRAAKAEQATVTSEF---ESYKVRVHNVLKQQKNKSMSQAE-TEG--AKQ 1349
Query: 657 EDEY-----DQLEQKFRTEQDKANFLSQQLEEIKHQ-----IAKNKAIEKGEVVSQEAEL 706
E E+ DQL+ K + Q+ +L+ ++ + NK ++ E VS+EAEL
Sbjct: 1350 EREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQ--ETVSKEAEL 1407
Query: 707 RHRFRLEEAKSRDLKAE----VQALKEKIHELMNK-EDQLSQLQVDYSVLQQRFMEEENK 761
R + ++++ +K+E V L + L N DQ+ LQ ++ + ++ +K
Sbjct: 1408 REKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSK 1467
Query: 762 NKNMGQEVLNLTKE-LELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETP 820
M ++ L E S S+ ++ RR D+P+ T +T
Sbjct: 1468 ---MEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTE 1524
Query: 821 AVFIRKSFQEENHIMSNLRQVGLKKPV 847
+V ++ + + N + L+ P+
Sbjct: 1525 SVSSASTYTQSLEQLLNSPETKLEPPL 1551
Score = 49.7 bits (117), Expect = 2e-05
Identities = 58/300 (19%), Positives = 142/300 (47%), Gaps = 30/300 (10%)
Query: 489 KAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLI 548
K E K+DL K +ML+ + K+ ++++E ++ ++ V +G D+ + L
Sbjct: 21 KLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEEL----RSKPVTEG-TGDIIKALT 75
Query: 549 EESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVE- 607
E LL K+E E++ +L +E ++ K + E+ + +L + ++ ++E+E
Sbjct: 76 ERLDALLLEKAETEQQCLSLKKENIKM--KQEVEDSVTKMGDAHKELEQSHINYVKEIEN 133
Query: 608 --REITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQ 665
E+ RS+ + + + + ++E L ++L+ E ++ K ++E +++
Sbjct: 134 LKNELMAVRSKYSEDKANLQKQLEEAMNTQLE-LSEQLKFQNNSEDNVKKLQEEIEKIRP 192
Query: 666 KFRTEQDKANFLSQQLE-----------EIKHQIAKNKAIEKGEVVSQEAELRHRFRLEE 714
F +++ +L +QL+ ++++ I N + + S + EL + +
Sbjct: 193 GF---EEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQ 249
Query: 715 AKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTK 774
+ ++L +++A ++ +NK ++L + ++++Q E+N K E+ NL K
Sbjct: 250 EEVKELMCQIEASAKEHEAEINKLNELKE-----NLVKQCEASEKNIQKKYECELENLRK 304
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 126 bits (317), Expect = 1e-28
Identities = 175/780 (22%), Positives = 348/780 (44%), Gaps = 123/780 (15%)
Query: 104 EKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYR 163
E+TK E+ + E E+ + L QEK+ D+ + SE + L + ++
Sbjct: 861 ERTKEELARSEARRKELEEKM------VSLLQEKN---DLQLQVQSETENLMDAEERCEG 911
Query: 164 RMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKS---DDFTNLLEQERERLKKLL---EQ 217
+ ++LL K T LE E+ +++ + K +D + L+++ + L+ L E+
Sbjct: 912 LIKSKILLEAKVKELTE-RLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEK 970
Query: 218 EKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQ---K 274
EK K K ++ + L + + KL L + Q ++ L ++ KV L + K
Sbjct: 971 EKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAK 1030
Query: 275 LR----------EEEEKLKAITSKSKE--------DRQKLLKLEVD---FEHKASRFSQE 313
L E+E+KL+A ++K ++ ++ LE D E K + E
Sbjct: 1031 LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFE 1090
Query: 314 HEEMNAKLANQESHNRQLRLKLVGLTQRIEELEE-------TNKNLQKAEEEL-QELRDK 365
++ AK+ +++ H+ Q + K+ L RIEELEE ++K +L +EL +
Sbjct: 1091 LSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEI 1150
Query: 366 IAKGECGNSSLMAEVENLRKRVLEME----GKDEEITKTESQCRELRKK----LQEEEHH 417
+ E + + A++E +KR E + +E + E+ LRKK + E
Sbjct: 1151 SERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQ 1210
Query: 418 SKELRLEVEKLQKRMSELEKLE--------EAFSKSKSECTQLHLNLEKEKNLTK----- 464
L+ +KL+K SEL K+E EA SKSKS + +E + + K
Sbjct: 1211 IDNLQRVKQKLEKEKSEL-KMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ 1269
Query: 465 --DLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEK---- 518
L+++L + K+R++ S + + SL LTK K ++E K ME+
Sbjct: 1270 QTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKA 1329
Query: 519 -------IKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRE 571
++ D L + ++ EQ ++ L + + ++ + +++ E T E
Sbjct: 1330 KNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEE 1389
Query: 572 RDELIGKLK---SEEEKSSELS----CSVDLLKKRLDG-IEEVEREITRG---------R 614
+E KL E E+++E + S++ K+RL G +E++ R++ R +
Sbjct: 1390 LEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKK 1449
Query: 615 SRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKA 674
R ++ K+ E E+E +K + L +L K + Y+++ + T + +
Sbjct: 1450 QRNFDKVLAEWKQKLDESQAELEAAQKESRSLST---ELFKMRNAYEEVVDQLETLRREN 1506
Query: 675 NFLSQQLEEIKHQIAK-NKAIEKGE----VVSQE--------AELRHRFRLEEAKSRDLK 721
L +++ ++ QIA+ K +++ E +V QE E+ EE+K ++
Sbjct: 1507 KNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQ 1566
Query: 722 AEVQALKEKI-HELMNKEDQLSQLQVD---YSVLQQRFMEEENKNKNMGQEVLNLTKELE 777
E+ +K ++ +++ K++++ QL+ + + Q ++ E +++N + L L K++E
Sbjct: 1567 LELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRN---DALRLKKKME 1623
Score = 119 bits (298), Expect = 2e-26
Identities = 173/858 (20%), Positives = 356/858 (41%), Gaps = 76/858 (8%)
Query: 37 KKKKKSNRKEDDVMASGTVKRHLKTSGE-CERKTKKSLELSKEDLIQLLSI---MEGELQ 92
K K ++ DD+ S ++ L+ E +RK + L++S+E ++ L + +E +L+
Sbjct: 1026 KINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLK 1085
Query: 93 AREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELD 152
+E + L+ + +V + E R+ + + E ++ +
Sbjct: 1086 KKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKI--------- 1136
Query: 153 RLEEKQKETYRRMLEQLL-LAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERL 211
EKQ+ R LE++ E+ T ++E K + ++ D Q E
Sbjct: 1137 ---EKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQH-EAT 1192
Query: 212 KKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDL 271
L +++A + E L +++ +L K KS M +D+ +IE L S+ ++
Sbjct: 1193 AATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEAL---SKSKSNI 1249
Query: 272 TQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQL 331
+ R E++ I +K ++ Q L D + +R ++ E++ ++ +ES QL
Sbjct: 1250 ERTCRTVEDQFSEIKAKDEQQTQ----LIHDLNMQKARLQTQNGELSHRVEEKESLISQL 1305
Query: 332 RLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEME 391
LTQ++EEL+ + KA+ + ++ +C E E K L+
Sbjct: 1306 TKSKQALTQQLEELKRQMEEETKAKNAMAHALQS-SRHDCDLLREQYEEEQEAKAELQ-- 1362
Query: 392 GKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSE-LEKLEEAFSKSKSECT 450
++K S+ + R K + + E E+E+ +K++++ L++ EE + S+C
Sbjct: 1363 ---RALSKANSEVAQWRTKYETDAIQRTE---ELEEAKKKLAQRLQEAEENTETANSKCA 1416
Query: 451 QLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVD 510
L ++ + +DL+ +LE + L+ + +K K L D
Sbjct: 1417 SLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKL-----------D 1465
Query: 511 ERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTR 570
E + +E ++E R + + +V+D E L E+K L + S++ E++ +
Sbjct: 1466 ESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGK 1525
Query: 571 ERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIK 630
E K E++ S+L +++ ++ L+ E + S+ SEL D K+
Sbjct: 1526 NLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSEL----DRKVI 1581
Query: 631 ELTLEIERLKKRLQQLEVVEGDLMKTE--DEYDQLEQKFRTEQDKANFLSQQLEEIKHQI 688
E EIE+LK+ Q+ ++ E D L K + E D N + QL Q+
Sbjct: 1582 EKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGD-LNEMEIQLGHSNRQM 1640
Query: 689 A---KNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEK----IHELMNKEDQL 741
A K+ +G++ + L R E DLK ++ ++ + + EL + L
Sbjct: 1641 AETQKHLRTVQGQLKDSQLHLDDALRSNE----DLKEQLAIVERRNGLLLEELEEMKVAL 1696
Query: 742 SQLQVDYSVLQQRFMEEENKNK---NMGQEVLNLTKELE-----LSKRYSRALRPSVNGR 793
Q + + +Q ++ ++ + + ++N K+LE +++ S N
Sbjct: 1697 EQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAE 1756
Query: 794 RMVDVPVTSTGVQTDAVSGE---AAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERS 850
+T + + + E +A E + ++ ++ H + Q+ LK ++
Sbjct: 1757 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI 1816
Query: 851 SVLD-RYPPAANELTMRK 867
L+ R NEL + +
Sbjct: 1817 QKLENRVRELENELDVEQ 1834
Score = 111 bits (277), Expect = 5e-24
Identities = 147/677 (21%), Positives = 313/677 (46%), Gaps = 73/677 (10%)
Query: 71 KSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEK--VLRVLH 128
KS + + L +L ME E +A+ + H L++ + ++L Y + K + R L
Sbjct: 1307 KSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALS 1366
Query: 129 R-DAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAE----KCH--RRTVY 181
+ ++ +AQ ++ E I + LEE +K+ +R+ E E KC +T
Sbjct: 1367 KANSEVAQWRTKYET---DAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQ 1423
Query: 182 ELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQ--EKAYQARKEKENAKRLNK-LRD 238
L+ E + +S L++++ K+L + +K +++ E E A++ ++ L
Sbjct: 1424 RLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLST 1483
Query: 239 ELVKLKSFALMLVDERQ-MHIEQLGLQSQKVQDLTQKLRE------EEEKLKAITSKSKE 291
EL K+++ +VD+ + + E LQ +++ DLT+++ E E EK K + + K
Sbjct: 1484 ELFKMRNAYEEVVDQLETLRRENKNLQ-EEISDLTEQIAETGKNLQEAEKTKKLVEQEKS 1542
Query: 292 DRQKLLK-LEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNK 350
D Q L+ +E EH+ S+ + E++ + +L K++ ++ EE+E+ +
Sbjct: 1543 DLQVALEEVEGSLEHEESKILRVQLELSQVKS-------ELDRKVI---EKDEEIEQLKR 1592
Query: 351 NLQKAEEELQELRDKIAKGECGNSSLMAEVE-NLRKRVLEMEGKDEEITKTESQCRELRK 409
N Q+A E LQ + D + L ++E +L + +++ + ++ +T+ R ++
Sbjct: 1593 NSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQG 1652
Query: 410 KLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNE 469
+L++ + H + E L+++++ +E+ + E ++ + LE+ + + E
Sbjct: 1653 QLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLE---ELEEMKVALEQTERTRRLSEQE 1709
Query: 470 LEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGL 529
L RV+ L + L + L+ D+ + ++ + E +N EK K+ +
Sbjct: 1710 LLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMM 1769
Query: 530 NKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIG-KLKSEEEKSSE 588
+ K EQ + S L ++K +E+ V +L DE LK +++ +
Sbjct: 1770 AEELKKEQ-----------DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1818
Query: 589 LSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEV 648
L V L+ LD ++ E +G + + K+KE+T + E K + +L+
Sbjct: 1819 LENRVRELENELDVEQKRGAEALKGAHKY--------ERKVKEMTYQAEEDHKNILRLQ- 1869
Query: 649 VEGDLM-KTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVV-SQEAEL 706
DL+ K + + +++ +++AN + ++H++ +A E+ ++ SQ +L
Sbjct: 1870 ---DLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHEL--EEAAERADIAESQVNKL 1924
Query: 707 RHRFRLEEAKSRDLKAE 723
R AKSRD+ ++
Sbjct: 1925 R-------AKSRDVGSQ 1934
Score = 102 bits (254), Expect = 2e-21
Identities = 135/602 (22%), Positives = 260/602 (43%), Gaps = 130/602 (21%)
Query: 343 EELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTES 402
E+ E T + L ++E +EL +K+ SL+ E +L+ L+++ + E + E
Sbjct: 858 EDFERTKEELARSEARRKELEEKMV-------SLLQEKNDLQ---LQVQSETENLMDAEE 907
Query: 403 QC--------------RELRKKLQEEEHHSKELRLEVEKLQKRMSELEK----LEEAFSK 444
+C +EL ++L+EEE + EL + L+ + S L++ LE +K
Sbjct: 908 RCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTK 967
Query: 445 SKSECTQLHLNLEKEKNLTKDL------------------------LNELEVVKSRVK-- 478
+ E H K KNL++++ L++L+V + +V
Sbjct: 968 VEKE---KHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGL 1024
Query: 479 ------------ELECS-------ESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKI 519
+LE S + LE+A+ L+ DL + + L ++++ + EK+
Sbjct: 1025 IKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKL 1084
Query: 520 KQEERKVDGLNKNFKVEQGKVMDVTEKL------IEESKKLLK----LKSEMEEKVYNLT 569
K++E ++ L EQ + +K+ IEE ++ ++ L++++E++ +L
Sbjct: 1085 KKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLA 1144
Query: 570 RERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVER---EITRGRSRKGSELTCPED 626
RE +E+ +L EE S S +++ KKR +++ R E T + L +
Sbjct: 1145 RELEEISERL---EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQA 1201
Query: 627 NKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEY-----------DQLEQKFRTEQDKAN 675
+ + EL +I+ L++ Q+LE + +L D+ +E+ RT +D+ +
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFS 1261
Query: 676 FLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELM 735
+ + +E + Q+ + ++K + +Q EL HR +E+ L QAL +++ EL
Sbjct: 1262 EIKAK-DEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEEL- 1319
Query: 736 NKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVL-------NLTKELELSKRYSRALRP 788
+R MEEE K KN L +L +E ++ ++A
Sbjct: 1320 -----------------KRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQ 1362
Query: 789 SVNGRRMVDVPVTSTGVQTDAVS-GEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPV 847
+ +V T +TDA+ E EE + R EEN +N + L+K
Sbjct: 1363 RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTK 1422
Query: 848 ER 849
+R
Sbjct: 1423 QR 1424
Score = 75.9 bits (185), Expect = 2e-13
Identities = 75/329 (22%), Positives = 148/329 (44%), Gaps = 51/329 (15%)
Query: 456 LEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNM 515
L K K++ E + +EL SE+R ++ E + L + + + E +N+
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL 902
Query: 516 MEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDEL 575
M+ E + +GL K+ + + KV ++TE+L EE + EL
Sbjct: 903 MD----AEERCEGLIKSKILLEAKVKELTERLEEEEEM------------------NSEL 940
Query: 576 IGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLE 635
+ K ++ E+K S L +D L+ L +E+ E+ T +NK+K L+ E
Sbjct: 941 VAKKRNLEDKCSSLKRDIDDLELTLTKVEK-EKHAT--------------ENKVKNLSEE 985
Query: 636 IERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKAN-------FLSQQLEEIKHQI 688
+ L++ + +L + L ++ + Q + E+DK N L QQ ++++ +
Sbjct: 986 MTALEENISKLTKEKKSL---QEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL 1042
Query: 689 AKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDY 748
+ K + + ++ + +L ++ + DL+ + Q ++EK L KE +LSQLQ
Sbjct: 1043 EQEKKL-RADLERAKRKLEGDLKMSQESIMDLENDKQQIEEK---LKKKEFELSQLQAKI 1098
Query: 749 SVLQQRFMEEENKNKNMGQEVLNLTKELE 777
Q ++ + K K + + L +E+E
Sbjct: 1099 DDEQVHSLQFQKKIKELQARIEELEEEIE 1127
Score = 66.6 bits (161), Expect = 1e-10
Identities = 108/466 (23%), Positives = 189/466 (40%), Gaps = 68/466 (14%)
Query: 26 NAGEKSLSE-DAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLL 84
NA E+ + + + +++ N +E+ + + K E E KTKK +E K DL L
Sbjct: 1490 NAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAE-KTKKLVEQEKSDLQVAL 1548
Query: 85 SIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVY 144
+EG L+ E I ++ E ++ + E +V+ +D + Q K +
Sbjct: 1549 EEVEGSLEHEESKILRVQLELSQ----------VKSELDRKVIEKDEEIEQLKRNSQRAA 1598
Query: 145 EKPISELD----------RLEEKQKETYRRMLEQL------LLAEKCHRRTVYELENEKH 188
E S LD RL++K + M QL + + H RTV +
Sbjct: 1599 EALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQ 1658
Query: 189 KHTDYMNKSDDF-----------TNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLR 237
H D +S++ LL +E E +K LEQ + + E+E L
Sbjct: 1659 LHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQE----LLDAS 1714
Query: 238 DELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLK-AITSKSKEDRQKL 296
D + L S L++ ++ + +V++ Q+ R EEK K AIT + +
Sbjct: 1715 DRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEE-- 1772
Query: 297 LKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLK-----LVGLTQRIEELE----- 346
LK E D R + E+ L ++ QL LK + L R+ ELE
Sbjct: 1773 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDV 1832
Query: 347 ------ETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVL----EMEGKDEE 396
E K K E +++E+ + + L V+ L+ +V + E +E+
Sbjct: 1833 EQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892
Query: 397 ITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSEL--EKLEE 440
S+CR ++ +L+E + +V KL+ + ++ +K+EE
Sbjct: 1893 ANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 126 bits (316), Expect = 1e-28
Identities = 210/940 (22%), Positives = 403/940 (42%), Gaps = 141/940 (15%)
Query: 20 KPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKED 79
K S+ ++ ++SL + ++ + D AS + + E E S L+KE
Sbjct: 81 KESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS--EAEDLVGNSDSLNKEQ 138
Query: 80 LIQLLSIMEGELQARED-------VIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAI 132
LIQ L ME L + ML+ EK K + + S +K LR R A
Sbjct: 139 LIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGIL----SQSQDKSLR---RIAE 191
Query: 133 LAQEKSIGEDVYEKPISELDR-LEEKQKETYRRMLEQLLLAEKCHR--------RTVYEL 183
L +E + + + E D LEEK + + LL ++ + + +L
Sbjct: 192 LREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQL 251
Query: 184 ENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKL 243
E + T N D ++E + +K L E Q K +EN L + ++ +
Sbjct: 252 EPQAEVFTKEENPESDGEPVVE-DGTSVKTL---ETLQQRVKRQENL--LKRCKETIQSH 305
Query: 244 KSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDF 303
K +L E++ EQL + Q+++ + K EK K IT + ++ + + +LE D
Sbjct: 306 KEQCTLLTSEKEALQEQLDERLQELEKI--KDLHMAEKTKLIT-QLRDAKNLIEQLEQD- 361
Query: 304 EHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAE-EELQEL 362
K ++ +M+ L +E QLR ++ +T + EEL E + ++A EEL++
Sbjct: 362 --KGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA 419
Query: 363 RDKIAKGECGNSSLMAEVENLRKRVLEMEGKD-----EEITKTESQCRELRKKLQEEEH- 416
K E L AE++ K + + ++ +E+++ + + ++ KK EE+
Sbjct: 420 LSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIA 479
Query: 417 -----HSKELRLEVEKLQKRMSELEK-----LEEAFSKSKSECTQL-------------H 453
H KEL + ++L K++ E+ ++ A KS+SE ++
Sbjct: 480 KLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEE 539
Query: 454 LNLEKEKNLT------KDLLNELEVVKSRVKELECS-ESRLEKAELSLKDDLTKL----- 501
L L+K+ LT +DL E E ++R+ ELE S E L++ + KD L
Sbjct: 540 LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
Query: 502 ---KSFTVMLVDERKNMMEKIKQEE-----RKVDGLNKNFKVEQGKVMDVTEKLIEESKK 553
K TVM V++ K +E +K ++ K+ L + ++ E K+ EK +E +
Sbjct: 600 KHNKEITVM-VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR---EKCEQEKET 655
Query: 554 LLKLKS--------EMEEKVY-----------NLTRERDELIGKLKSEEEKSSELSCSVD 594
LLK K EM EK +L+ E E++ EE+ S L D
Sbjct: 656 LLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTD 715
Query: 595 LLKKRLDG------------IEEV--EREITRGRSRKGSELTCPEDNKIKELTLEIER-L 639
+K+ L+ ++ + E E++ R+ K + + N+++ L E ++ L
Sbjct: 716 KMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALK---DQINQLELLLKERDKHL 772
Query: 640 KKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEV 699
K+ +E +E D+ ++E E Q K Q + +Q + + Q+A+ + + ++
Sbjct: 773 KEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ-KLLDL 831
Query: 700 VSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNK-EDQLSQLQVDYSVLQQRF--- 755
++ L + EA+ +D+ E+ A K ++ +LM + E Q S+++ L Q +
Sbjct: 832 ETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESK 891
Query: 756 MEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAA 815
+E+ NK + +++L + + L R + ++ +++ + D++
Sbjct: 892 LEDGNKEQEQTKQILVEKENMILQMREGQ--------KKEIEILTQKLSAKEDSIHILNE 943
Query: 816 EEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERSSVLDR 855
E ET K ++ +++ KK +++ + L +
Sbjct: 944 EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKK 983
Score = 116 bits (291), Expect = 1e-25
Identities = 166/756 (21%), Positives = 331/756 (43%), Gaps = 99/756 (13%)
Query: 29 EKSLS-----EDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQL 83
EK+LS E+A++K K+ E +K KTS E ++ L K++++ +
Sbjct: 417 EKALSTAQKTEEARRKLKAEMDEQ-------IKTIEKTSEEERISLQQELSRVKQEVVDV 469
Query: 84 LSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDV 143
+ E A+ +H E E E ++ R+ ++ +
Sbjct: 470 MKKSSEEQIAKLQKLH------------EKELARKEQELTKKLQTREREFQEQMKVA--- 514
Query: 144 YEKPISELDRLEEKQKETYRRMLEQLLLAEKC----HRRTVYELENEKHKH-TDYMNKSD 198
EK SE ++ +++++ LE+L L +K + +L+ E + T +
Sbjct: 515 LEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELES 574
Query: 199 DFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHI 258
L++ + + K L +A + + KE + K + EL LK
Sbjct: 575 SLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKH------------- 621
Query: 259 EQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMN 318
+Q L ++K+Q L Q+ + E EKL+ K +++++ LLK K F EEMN
Sbjct: 622 QQDALWTEKLQVLKQQYQTEMEKLR---EKCEQEKETLLK------DKEIIFQAHIEEMN 672
Query: 319 AKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMA 378
K + L +K L EL E K K EEEL L+D+ K + + M
Sbjct: 673 EKTLEK------LDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMD 726
Query: 379 EVENLRKRVLEMEGKDEEIT--KTES----QCRELRKKLQEEEHHSKELRLEVEKLQKRM 432
E +N ++ ++ K+ E++ +TE Q +L L+E + H KE + VE L+ +
Sbjct: 727 EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADI 786
Query: 433 SELE-KLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEK-- 489
E +L++A +K + Q + + E+ TK +L ++ ++ +LE L K
Sbjct: 787 KRSEGELQQA--SAKLDVFQSYQSATHEQ--TKAYEEQLAQLQQKLLDLETERILLTKQV 842
Query: 490 --AELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNF--KVEQG-KVMDVT 544
E KD T+L + + + D + + ++ + E+KV L + + K+E G K + T
Sbjct: 843 AEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQT 902
Query: 545 EK-LIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGI 603
++ L+E+ +L+++ ++++ LT++ L K S + E +K+++ +
Sbjct: 903 KQILVEKENMILQMREGQKKEIEILTQK---LSAKEDSIHILNEEYETKFKNQEKKMEKV 959
Query: 604 EEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRL--QQLEVVEGDLMKTEDEYD 661
++ +E+ +K + +++ LE+ + +K+ + LE+ + + D
Sbjct: 960 KQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVS 1019
Query: 662 QLE--QKFRTEQ----------DKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHR 709
+LE QK + E D + ++L + ++ + I+ E + AEL+ +
Sbjct: 1020 RLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQK 1079
Query: 710 FRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQ 745
L + ++ E+ LKE E + ++ L++LQ
Sbjct: 1080 ILLFGCEKEEMNKEITWLKE---EGVKQDTTLNELQ 1112
Score = 110 bits (275), Expect = 8e-24
Identities = 154/735 (20%), Positives = 334/735 (45%), Gaps = 108/735 (14%)
Query: 110 VLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPI---SELDRLEEKQKETYRRML 166
+ E+ + S+ E ++R R+++ + ++ P SE + L + L
Sbjct: 80 IKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQL 139
Query: 167 EQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKE 226
Q L RR L + + K+++ + +L++E+++L+ +L Q + R+
Sbjct: 140 IQRL------RRMERSLSSYRGKYSELVTAYQ----MLQREKKKLQGILSQSQDKSLRRI 189
Query: 227 KENAKRLNKLRDELVKLKSFALMLVDERQMHIE----QLGLQSQKVQ------DLTQKLR 276
E + L + L+ ++E+ +I Q+ L Q+++ D+ + L
Sbjct: 190 AELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLP 249
Query: 277 EEEEKLKAITS------------------KSKEDRQKLLKLEVDFEHKASRFSQEHEEMN 318
+ E + + T K+ E Q+ +K + + + Q H+E
Sbjct: 250 QLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQC 309
Query: 319 AKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEE-----ELQELRDKIAKGECGN 373
L +++ ++ L +R++ELE+ K+L AE+ +L++ ++ I + E
Sbjct: 310 TLLTSEKEALQEQ------LDERLQELEKI-KDLHMAEKTKLITQLRDAKNLIEQLEQDK 362
Query: 374 SSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQE-EEHHSKELRLEVEKLQKRM 432
++AE + LEM K+EEI + S+ +++ + +E E K R E+L+K +
Sbjct: 363 GMVIAETKRQMHETLEM--KEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKAL 420
Query: 433 SELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAEL 492
S +K EEA K K+E + +++ E E+ +
Sbjct: 421 STAQKTEEARRKLKAEMDE---------------------------QIKTIEKTSEEERI 453
Query: 493 SLKDDLTKLKSFTVMLV----DERKNMMEKIKQEE--RKVDGLNKNFKVEQGKVMDVTEK 546
SL+ +L+++K V ++ +E+ ++K+ ++E RK L K + + + + +
Sbjct: 454 SLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKV 513
Query: 547 LIEESK-KLLKLKSEMEEKVYNLTRERDELIGK--LKSEEEKSSELSCSVDLLKKRLDGI 603
+E+S+ + LK+ E E++ +L E EL K L E K +L + + R+ +
Sbjct: 514 ALEKSQSEYLKISQEKEQQ-ESLALEELELQKKAILTESENKLRDLQQEAETYRTRILEL 572
Query: 604 E-EVEREITRGRSRK---GSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDE 659
E +E+ + +++ L ++ KE+T+ +E+ K L+ L+ + D + TE +
Sbjct: 573 ESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLK-HQQDALWTE-K 630
Query: 660 YDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNK-AIEKGEVVSQEAELRHRFRLEEAKSR 718
L+Q+++TE +K L ++ E+ K + K+K I + + + + +++ +
Sbjct: 631 LQVLKQQYQTEMEK---LREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELE 687
Query: 719 DLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKN-MGQEVLNLTKELE 777
L +E+ + + H+L E++LS L+ ++Q + ++ KN Q+V ++ KE E
Sbjct: 688 SLSSELSEVLKARHKL---EEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHE 744
Query: 778 LS-KRYSRALRPSVN 791
+S +R +AL+ +N
Sbjct: 745 VSIQRTEKALKDQIN 759
Score = 103 bits (256), Expect = 1e-21
Identities = 176/824 (21%), Positives = 355/824 (43%), Gaps = 116/824 (14%)
Query: 30 KSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGE-------CERKTKKSLELSKEDLIQ 82
K+ E+ + K S+ K + + +++ K S E C +KT+ LE +LI
Sbjct: 1179 KTTDEEFQSLKSSHEKSNKSLEDKSLE-FKKLSEELAIQLDICCKKTEALLEAKTNELIN 1237
Query: 83 LLSIMEGELQAREDVIHML-KTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILA------- 134
+ S + +R + H +T K K +L +E E LR L +
Sbjct: 1238 ISSSKTNAILSR--ISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295
Query: 135 ---------QEKSIGEDVYEKPISELDRLEEK---------QKETYRRMLEQLLLAEKCH 176
Q KS+ D+ E ++E + L+++ +KE+ L++ L +E +
Sbjct: 1296 THQLEEKENQIKSMKADI-ESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL-SENIN 1353
Query: 177 RRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARK---EKENAKRL 233
T+ + E K K + + S T+L Q + + L E+E A + + ++E + L
Sbjct: 1354 AVTLMK-EELKEKKVEISSLSKQLTDLNVQLQNSIS-LSEKEAAISSLRKQYDEEKCELL 1411
Query: 234 NKLRD------ELVKLKSFALMLVDERQMHIEQLGLQSQ----KVQDLTQKLREEEEKLK 283
++++D L K K AL VD+ + ++Q + Q+ ++L+ + E LK
Sbjct: 1412 DQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE-LK 1470
Query: 284 AITSKSKEDRQKLLKLEVDFEHKA------------SRFSQEHEEMNAKLANQESHNRQL 331
+ + K+++ LLK E+D ++K S+ ++ + +L +Q + +L
Sbjct: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMEL 1530
Query: 332 RLKLVGLTQRIEELEETNKNL-QKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEM 390
+ T IE L E KN Q+ + E +EL K+ + V+ +++L +
Sbjct: 1531 EDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTL 1590
Query: 391 EGK------DEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSK 444
E + + E K E + L K +EEE + E RLE E K K E+ +
Sbjct: 1591 ENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAA 1650
Query: 445 SKSEC-TQLHLNLEKEKNLTKDLLNELEV-VKSRVKELECSESRLEKAELSLKDDLTKLK 502
K + +Q+ E+ K T+ L+EL ++ R +E+ E +L+ E S +
Sbjct: 1651 IKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESS--------Q 1702
Query: 503 SFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEME 562
S T+++ KN+ +QEE G + K + K+ + L E+ K L ++ E E
Sbjct: 1703 SETLIVPRSAKNVAAYTEQEEADSQGCVQ--KTYEEKISVLQRNLTEKEKLLQRVGQEKE 1760
Query: 563 EKV---YNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGS 619
E V + + + E + KL+ E K E + L++ L+ +++K S
Sbjct: 1761 ETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEE-----------KNKKYS 1809
Query: 620 ELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQ 679
+ +E E K +Q + E+ +D +++ + ++ L Q
Sbjct: 1810 LIVAQH--------VEKEGGKNNIQAKQ-------NLENVFDDVQKTLQEKELTCQILEQ 1854
Query: 680 QLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEV--QALKEKIHELMNK 737
+++E+ + + K + + E+ ++ L++ R+ E+ + +EK + +
Sbjct: 1855 KIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQ 1914
Query: 738 EDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKR 781
LS ++ ++ L+ + E + + +G+E++ L K+L + ++
Sbjct: 1915 PKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRK 1958
Score = 96.7 bits (239), Expect = 1e-19
Identities = 183/879 (20%), Positives = 369/879 (41%), Gaps = 181/879 (20%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVM---ASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLS 85
E + E ++K+K+ N K ++ ++G + + + + E+ + +L ++S
Sbjct: 986 ENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVIS 1045
Query: 86 IMEGEL--QARE-DVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGED 142
I E +L QA E IH ++ ++ + EV E +K+L + EK +
Sbjct: 1046 IWEKKLNQQAEELQEIHEIQLQEKEQEVAELK------QKIL-------LFGCEK----E 1088
Query: 143 VYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYM----NKSD 198
K I+ L KQ T + EQL + H ++ + E + H + + NKS
Sbjct: 1089 EMNKEITWLKEEGVKQDTTLNELQEQLK-QKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
Query: 199 DFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSF---ALMLVDERQ 255
L+++ LK L E++K RK E +L +E LKS + ++++
Sbjct: 1148 KENTFLQEQLVELKMLAEEDK----RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
Query: 256 MHIE--------QLGLQSQKVQDLTQKLREE-----EEKLKAITSKSKEDRQKLLKLEV- 301
+ + QL + +K + L + E K AI S+ + + K++
Sbjct: 1204 LEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEA 1263
Query: 302 ---------DFEHKASRFSQEHEEMNA-------KLANQESHNRQLRLKLVGLTQRIEEL 345
+ E + + ++E +N +L +E+ + ++ + L E L
Sbjct: 1264 LLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL 1323
Query: 346 EETNKNLQKAEEELQELRDKIAKGECGNSSLMAEV-ENLRKRVLEMEGKDEEIT------ 398
++ N Q+A E + ++ K N + + + E L+++ +E+ +++T
Sbjct: 1324 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1383
Query: 399 -------KTESQCRELRKKLQEEE----HHSKELRLEVEKLQK-RMSELEKLEE---AFS 443
+ E+ LRK+ EE+ ++L +V+ L K ++S LE++++ FS
Sbjct: 1384 QNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFS 1443
Query: 444 KSKSECT-------------QLHLNLEKEKNLTKD-----LLNELEVVKSRVK----ELE 481
+ K + Q+ L L+ ++ KD L EL+ R E+E
Sbjct: 1444 EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1503
Query: 482 CSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLN---KNFKVEQ- 537
+S++EK E +L+ T+LKS T +++ + + I Q+ +++ LN KN+ ++
Sbjct: 1504 DDKSKMEKKESNLE---TELKSQTARIME----LEDHITQKTIEIESLNEVLKNYNQQKD 1556
Query: 538 ---------------------GKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELI 576
+V + EK++ ++ +K+E+E K L E L
Sbjct: 1557 IEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKEL--EHVNLS 1614
Query: 577 GKLKSEEEKS------SELSCSVDLLKKR------------LDGIEEVEREITRGRSRKG 618
K K EE K+ SE + + LK++ L +EE E + +G
Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHL 1674
Query: 619 SELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLM------------KTEDEYDQLEQK 666
SEL + K++E E+ L+++L+ +E + + + ++E D
Sbjct: 1675 SEL----NTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCV 1730
Query: 667 FRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQA 726
+T ++K + L + L E K ++ + EK E VS E+R +++ K +A+
Sbjct: 1731 QKTYEEKISVLQRNLTE-KEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHE 1789
Query: 727 LKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNM 765
+ I L +++L + YS++ + +E+E N+
Sbjct: 1790 DQSMIGHL---QEELEEKNKKYSLIVAQHVEKEGGKNNI 1825
Score = 67.8 bits (164), Expect = 6e-11
Identities = 71/315 (22%), Positives = 143/315 (45%), Gaps = 24/315 (7%)
Query: 135 QEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYM 194
QEK + + E+ I ELD +QKE +R +E+ L K + + + ++K T+ +
Sbjct: 1843 QEKELTCQILEQKIKELDSCLVRQKEVHRVEMEE--LTSKYEKLQALQQMDGRNKPTELL 1900
Query: 195 NKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDER 254
++ + + + +L +E + K + KL E+V+L+ ML E
Sbjct: 1901 EENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEH 1960
Query: 255 QMHIEQLGLQSQKVQDLTQKLREEEEKLK-----AITSKSKEDRQKLLKLEVDFEHKASR 309
Q +E L+ + Q+ +K+++E+E L+ + +E +L + E + E
Sbjct: 1961 QQELEI--LKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKE 2018
Query: 310 FSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKG 369
+ +E+ A+L ESH + L ++I E ++ K K EE+ + R++
Sbjct: 2019 TINKAQEVEAELL--ESHQEETN----QLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Query: 370 ECGNSSLMAEVENLRKRV---LEME---GKDE-EITKTESQCRELRKKLQEEEHHSKELR 422
+ L ++E L+K+ LE E G D I + ++Q + + + + +E R
Sbjct: 2073 KV--RDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFR 2130
Query: 423 LEVEKLQKRMSELEK 437
++ L+ R+ + EK
Sbjct: 2131 EQIHNLEDRLKKYEK 2145
Score = 66.2 bits (160), Expect = 2e-10
Identities = 114/527 (21%), Positives = 223/527 (42%), Gaps = 78/527 (14%)
Query: 1 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLK 60
M + + + ++ H+S + E + E+ K +S++ E ++
Sbjct: 1659 MEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAY 1718
Query: 61 TSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSA-- 118
T E E ++ ++ + E+ I S+++ L +E ++ + EK E + +H+
Sbjct: 1719 TEQE-EADSQGCVQKTYEEKI---SVLQRNLTEKEKLLQRVGQEKE--ETVSSHFEMRCQ 1772
Query: 119 EPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAE--KCH 176
E+++++ H +A +++S+ + E+ LEEK K+ Y ++ Q + E K +
Sbjct: 1773 YQERLIKLEHAEAKQHEDQSMIGHLQEE-------LEEKNKK-YSLIVAQHVEKEGGKNN 1824
Query: 177 RRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKL 236
+ LEN + + + +LEQ+ + L L ++K + +E + KL
Sbjct: 1825 IQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKL 1884
Query: 237 ------------------------RDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLT 272
+ LV+ K + M + + G + +K
Sbjct: 1885 QALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREK----- 1939
Query: 273 QKLREEEEKL-KAITSKSKEDRQKL--LKLEVDFEHKASRFSQEHEEMNAKLANQESHNR 329
QKL +E +L K + KE +Q+L LK E D E + + QE E++ K HN
Sbjct: 1940 QKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE-EKIKQEQEDLELK------HNS 1992
Query: 330 QLRLKL----VGLTQRIEELEETNKN-LQKAEEELQELRDKIAKGECGNSSLMAEVENLR 384
L+ + L Q+ +ELE T K + KA+E EL + S E L
Sbjct: 1993 TLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLE----------SHQEETNQLL 2042
Query: 385 KRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSK--ELRLEVEKLQKRMSELEKLEEAF 442
K++ E KD+++ +T + E+ +EEE +K +L+ ++E+LQK+ + + EE
Sbjct: 2043 KKIAE---KDDDLKRTAKRYEEILDA-REEEMTAKVRDLQTQLEELQKKYQQKLEQEENP 2098
Query: 443 SKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEK 489
+L L ++ L D + + + ++ LE + EK
Sbjct: 2099 GNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEK 2145
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 125 bits (315), Expect = 2e-28
Identities = 156/702 (22%), Positives = 307/702 (43%), Gaps = 84/702 (11%)
Query: 130 DAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHK 189
+ ++A+E+ + + V EK ++ +RL E + + M E+L L E+ T E E+ +
Sbjct: 845 EEMMAKEEELVK-VREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELR 903
Query: 190 HTDYMNKSD------DFTNLLEQERERLKKLLEQEKAYQAR--------KEKENAKR--- 232
K + D +E+E ER + L ++K Q +E+E+A++
Sbjct: 904 ARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQ 963
Query: 233 LNKLRDE--LVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSK 290
L K+ E L KL+ ++L D+ ++ L ++ + T L EEEEK K++ +K K
Sbjct: 964 LEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSL-AKLK 1022
Query: 291 EDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNK 350
+ ++ D E + R ++ +E+ E + L ++ L +I EL+
Sbjct: 1023 NKHEAMI---TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELK---M 1076
Query: 351 NLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEM----EGKDEEITKTESQCRE 406
L K EEELQ ++ + + + ++ L ++ E+ E + K E Q R+
Sbjct: 1077 QLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRD 1136
Query: 407 LRKKLQ----EEEHHSKELRLEVEKLQKRMSELEKLEEAFSK-SKSECTQLHLNLEKEKN 461
L ++L+ E E + E KR E+ L++ + +K+ Q+ +K
Sbjct: 1137 LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ 1196
Query: 462 LTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQ 521
++L +LE K RVK + LEKA+ +L+++ +L + +L+ + + K K+
Sbjct: 1197 AVEELAEQLEQTK-RVK------ANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249
Query: 522 EERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKS 581
E ++ L F + ++++E+ +KV L E D + G L
Sbjct: 1250 VEAQLQELQVKFNEGE------------------RVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 582 EEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPED--NKIKELTLEIERL 639
+ KSS+L+ L+ +L +E+ +E R + ++L ED N +E E E
Sbjct: 1292 SDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA 1351
Query: 640 KKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEV 699
K L++ + + Q+ + +D L + EE+K ++ K+ +G
Sbjct: 1352 KHNLEK---------QIATLHAQVADMKKKMEDSVGCL-ETAEEVKRKLQKDL---EGLS 1398
Query: 700 VSQEAELRHRFRLEEAKSR------DLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQ 753
E ++ +LE+ K+R DL ++ ++ L K+ + QL + +
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA 1458
Query: 754 RFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRM 795
++ EE ++ + +E TK L L++ A+ R+
Sbjct: 1459 KYAEERDRAEAEARE--KETKALSLARALEEAMEQKAELERL 1498
Score = 111 bits (277), Expect = 5e-24
Identities = 172/805 (21%), Positives = 335/805 (41%), Gaps = 105/805 (13%)
Query: 32 LSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGEL 91
+ E+A +K + +K ++ + + L+ E ER ++ E K DL + EL
Sbjct: 1092 VEEEAAQKNMALKKIRELESQIS---ELQEDLESERASRNKAEKQKRDLGE-------EL 1141
Query: 92 QAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGED--VYEKPIS 149
+A LKTE LE S ++ LR + +K++ E+ +E I
Sbjct: 1142 EA-------LKTE------LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188
Query: 150 ELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERE 209
E+ + + E LEQ + + LENE+ + + + E +R+
Sbjct: 1189 EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRK 1248
Query: 210 RLKKLLEQEKAYQARKEK---ENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQ 266
+++ L++ + E+ E A ++ KL+ EL + + +
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 267 KVQDLTQKLREEEEKLKAITSKSK--EDRQKLLKLEVDFEHKASR--------------- 309
++QD + L+EE + ++++K K ED + + +++ E +A
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 310 FSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEE-------LEETNKNLQKAEEELQEL 362
++ E+ L E R+L+ L GL+QR EE LE+T LQ+ ++L
Sbjct: 1369 MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVD 1428
Query: 363 RDKIAKGECG-------NSSLMAEVENLRKRV------LEMEGKDEEITKTESQCRELRK 409
D + C L+AE + + + E E +++E TK S R L +
Sbjct: 1429 LDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKE-TKALSLARALEE 1487
Query: 410 KLQEE---EHHSKELRLEVEKLQ-------KRMSELEKLEEAFSKSKSECTQLHLNLEKE 459
++++ E +K+ R E+E L K + ELEK + A + E LE E
Sbjct: 1488 AMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE 1547
Query: 460 KNLTKDLLNELEVVKSRVK-ELECS-ESRLEKAELSLKDDLTKLKSFTVMLVDERKNMME 517
T+D LEV +K + E + R E++E K + +++ L DERK
Sbjct: 1548 LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSM 1607
Query: 518 KIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNL--TR-ERDE 574
+ ++ L + K + + + E K+L KL+++M++ + L TR R+E
Sbjct: 1608 AVAARKK----LEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREE 1663
Query: 575 LIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTL 634
++ + K E+K + + L++ L E +R+ + R E+ L
Sbjct: 1664 ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALE- 1722
Query: 635 EIERLKKRLQQL-----------EVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEE 683
E RL+ R+ QL E++ L K + DQ+ E+ A Q+ E
Sbjct: 1723 EKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHA----QKNEN 1778
Query: 684 IKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKI-HELMNKEDQLS 742
+ Q+ + K ++ E ++ +++ A L+A++ L+E++ +E ++
Sbjct: 1779 ARQQLERQNKELKVKLQEMEGTVKSKYK---ASITALEAKIAQLEEQLDNETKERQAACK 1835
Query: 743 QLQVDYSVLQQRFMEEENKNKNMGQ 767
Q++ L+ ++ +++ +N Q
Sbjct: 1836 QVRRTEKKLKDVLLQVDDERRNAEQ 1860
Score = 93.6 bits (231), Expect = 1e-18
Identities = 109/528 (20%), Positives = 250/528 (47%), Gaps = 75/528 (14%)
Query: 310 FSQEHEEMNAKLANQESHNRQLRLK------LVGLTQRIEELEETNKNLQKAEEELQELR 363
F++ +++ A Q + L+L+ L + + ++ + + EEEL ++R
Sbjct: 799 FAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVR 858
Query: 364 DK-------IAKGECGNSSLMAEVENLRKRV---LEMEGKDEEI--------TKTESQCR 405
+K + + E S LMAE L++++ E+ + EE+ + E C
Sbjct: 859 EKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICH 918
Query: 406 ELRKKLQEEEHHSKELRLEVEKLQKRMSELEKL--EEAFSKSKSECTQLHL-----NLEK 458
+L +++EEE + L+ E +K+Q+ + ELE+ EE ++ K + ++ LE+
Sbjct: 919 DLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEE 978
Query: 459 EKNLTKD----LLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKS-FTVMLVDERK 513
E+ + +D L E ++++ R+ E + + E+ S L KLK+ M+ D
Sbjct: 979 EQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKS----LAKLKNKHEAMITD--- 1031
Query: 514 NMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERD 573
+ E++++EE++ L K + +G D+++++ E ++ +LK + L ++ +
Sbjct: 1032 -LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQ-------LAKKEE 1083
Query: 574 ELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRK----------GSELTC 623
EL L EE++++ + ++ +++ I E++ ++ R+ + G EL
Sbjct: 1084 ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEA 1143
Query: 624 PE---DNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKA-NFLSQ 679
+ ++ + + E KR Q++ +++ L + ++ Q+ R + +A L++
Sbjct: 1144 LKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAE 1203
Query: 680 QLEE---IKHQIAKNKAI---EKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHE 733
QLE+ +K + K K E+GE+ ++ L E K + ++A++Q L+ K +E
Sbjct: 1204 QLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNE 1263
Query: 734 ----LMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELE 777
D++++LQV+ + + ++K+ + ++ L +L+
Sbjct: 1264 GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ 1311
Score = 84.0 bits (206), Expect = 8e-16
Identities = 120/568 (21%), Positives = 232/568 (40%), Gaps = 64/568 (11%)
Query: 29 EKSLSEDAKKKKKSNRKE--DDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSI 86
EK + D +K K+ ++ DD++ +R +++ E+K KK +L E+
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQR--QSACNLEKKQKKFDQLLAEEKTISAKY 1460
Query: 87 ME----GELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGED 142
E E +ARE L + E +E K R D +++ + +G+
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMED-LMSSKDDVGKS 1519
Query: 143 VYEKPISE--LDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDF 200
V+E S+ L++ E+ K + ++L E R L+ K + + D
Sbjct: 1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRD-- 1577
Query: 201 TNLLEQERERLKKLLEQEKAYQARKEKENAKRL------NKLRDELVKLKSFALMLVDER 254
EQ E+ K+L+ Q + +A E E +R KL +L L++ R
Sbjct: 1578 ----EQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR 1633
Query: 255 QMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEH 314
I+QL +++D ++L + + I +++KE+ +KL +E +
Sbjct: 1634 DEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAE------------ 1681
Query: 315 EEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNS 374
+ Q EEL + ++A++E EL D+IA +
Sbjct: 1682 -----------------------MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 375 SLMAEVENLRKRVLEMEGK-DEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMS 433
+ E L R+ ++E + +EE TE L+K + + + +L LE QK +
Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNEN 1778
Query: 434 ELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAEL- 492
++LE + K + ++ + K+ K + LE ++++E +E++ +A
Sbjct: 1779 ARQQLERQNKELKVKLQEMEGTV---KSKYKASITALEAKIAQLEEQLDNETKERQAACK 1835
Query: 493 SLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESK 552
++ KLK + + DER+N E+ K + K K K + + + ++ +
Sbjct: 1836 QVRRTEKKLKDVLLQVDDERRN-AEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRR 1894
Query: 553 KLLKLKSEMEEKVYNLTRERDELIGKLK 580
KL + + E + RE L KL+
Sbjct: 1895 KLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 82.0 bits (201), Expect = 3e-15
Identities = 91/411 (22%), Positives = 194/411 (47%), Gaps = 49/411 (11%)
Query: 385 KRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSK 444
K +L++ ++EE+ E + ++R+K E+ E+ +L +L++ +A ++
Sbjct: 835 KPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETE 894
Query: 445 SKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSF 504
+E +L L +K +++ ++LE +RV+E E L+ + ++ ++ +L+
Sbjct: 895 LCAEAEELRARLTAKKQELEEICHDLE---ARVEEEEERCQHLQAEKKKMQQNIQELEE- 950
Query: 505 TVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEK 564
++E ++ +K++ E+ + K + EQ + D KL +E K L+ + E
Sbjct: 951 ---QLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKK---LLEDRIAEF 1004
Query: 565 VYNLT--RERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELT 622
NLT E+ + + KLK++ E + L++RL E+ +E+ + R + + T
Sbjct: 1005 TTNLTEEEEKSKSLAKLKNKHE------AMITDLEERLRREEKQRQELEKTRRKLEGDST 1058
Query: 623 CPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLE 682
D +I EL +I LK + L K E+E + E + N +++
Sbjct: 1059 DLSD-QIAELQAQIAELKMQ----------LAKKEEELQAALARVEEEAAQKNMALKKIR 1107
Query: 683 EIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMN----KE 738
E++ QI+ E E + E R++ E + RDL E++ALK ++ + ++ ++
Sbjct: 1108 ELESQIS-----ELQEDLESERASRNK---AEKQKRDLGEELEALKTELEDTLDSTAAQQ 1159
Query: 739 DQLSQLQVDYSVLQQRFMEE--------ENKNKNMGQEVLNLTKELELSKR 781
+ S+ + + ++L++ EE + + Q V L ++LE +KR
Sbjct: 1160 ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 124 bits (311), Expect = 5e-28
Identities = 187/890 (21%), Positives = 383/890 (43%), Gaps = 78/890 (8%)
Query: 25 GNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQ-- 82
G+ GE +L+ ++ D+ AS +K S E +++ +K L +++
Sbjct: 71 GHGGESNLALKRDDVTLLRQEVQDLQAS--LKEEKWYSEELKKELEKYQGLQQQEAKPDG 128
Query: 83 LLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGED 142
L++ ELQ+ E + +TE + ++ + + + + +E+S+ E
Sbjct: 129 LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 143 VYEKPISELDRL-EEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFT 201
+K + RL EE KE + Q L E R + ++ K + D+ T
Sbjct: 189 AEQK----VTRLTEELNKEA---TVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMT 241
Query: 202 NLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQL 261
LE+ERE +KL ++ K Q++ A +++LR EL K + V E Q +
Sbjct: 242 --LERERES-EKLKDECKKLQSQYASSEAT-ISQLRSELAKGPQEVAVYVQELQKLKSSV 297
Query: 262 GLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKL 321
+QK Q LT+ L ++E+ + K E+ ++ K + +++ ++L
Sbjct: 298 NELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQK----DLDCQQLQSRL 353
Query: 322 ANQESHNRQLRLKLV---GLTQRI-EELEETNKNLQKAEEELQELRDKIAKGECGNSSLM 377
+ E+ ++ ++L TQ++ EEL E Q + E ++L+ + + E L
Sbjct: 354 SASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQ 413
Query: 378 AEVENLRKRVLEMEGKDEEITKTESQCREL-RKKLQEEEHHSKELRLEVEKLQKRMSE-- 434
+E+ L ++LE E + E + R+L +KL ++E +L+L++ +L++++ E
Sbjct: 414 SEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKV 473
Query: 435 --LEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAEL 492
+L+ K+K + + + ++ N+LE V ++ + + LE
Sbjct: 474 TNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEAL-- 531
Query: 493 SLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLN----KNFKVEQGKVMDVTEKLI 548
L K K +L ER+++ KI+ E + LN KN +++ +V +TEKL
Sbjct: 532 -----LQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQE-QVTQLTEKLK 585
Query: 549 EESKKLLK----LKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCS---VDLLKKRLD 601
+S+ + L +++E+ +L +D ++ S E +S+L+ S V L ++
Sbjct: 586 NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645
Query: 602 GIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYD 661
E+ ++ + ++L D L + + L K QL+ V L ++
Sbjct: 646 AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS 705
Query: 662 QLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQE------------------ 703
QLE + ++K L Q+ EE++ QI K +A S+E
Sbjct: 706 QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 765
Query: 704 --AELRHRFRLEE----AKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFME 757
EL + +E+ + DL+ + +AL+ +L +E++ L+ D+ L Q E
Sbjct: 766 RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ---E 822
Query: 758 EENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEE 817
+ +++ + + EL+ K AL ++ + + S ++ E +
Sbjct: 823 TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK-DKLSKVSDSLKNSKSEFEKENQ 881
Query: 818 ETPAVF--IRKSFQEENHIMSNLRQVGLKKPVERSSVLDRYPPAANELTM 865
+ A + K+ +E H + + LK+ E L++ A+++L +
Sbjct: 882 KGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKL 931
Score = 122 bits (305), Expect = 3e-27
Identities = 193/913 (21%), Positives = 389/913 (42%), Gaps = 124/913 (13%)
Query: 59 LKTSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVI-HMLKTEKTKPEVLEAHYGS 117
L GE +K K+ L + L + + Q RE+ H L+ + E+ + H
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQS---EINQLHSKL 423
Query: 118 AEPEKVLRVLH----RDAILAQEKSIGEDVYEKPIS-ELDRLEEKQKETYRRMLEQLLLA 172
E E+ L H L+ EK + ++ + +L RLEE+ KE E
Sbjct: 424 LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL 483
Query: 173 EKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKR 232
+K ++ + ++ +D +L Q ++ +K+ E Q K KEN
Sbjct: 484 DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQ--KSKENISL 541
Query: 233 LNKLRDEL-VKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKA------- 284
L K R++L K+++ Q+ + LQ Q Q LT+KL+ + E K
Sbjct: 542 LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQ-LTEKLKNQSESHKQAQENLHD 600
Query: 285 -------------------------ITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNA 319
+ S+ E ++K+ +L++ + K A
Sbjct: 601 QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA 660
Query: 320 KLANQESH-----------NRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAK 368
+ A+ ++H ++L L Q +L++ ++ + E L+E ++K
Sbjct: 661 QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLS 720
Query: 369 GECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQ-EEEHHSKELRLEVE- 426
E L +++ L LE++ E+ + Q R+L L+ SK+L +E E
Sbjct: 721 LEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI 780
Query: 427 ------KLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTK----DLLNELEVVKSR 476
LQK+ LE +++ +K + E L + E TK +L N ++ +
Sbjct: 781 VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE 840
Query: 477 VKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERK----VDGLNKN 532
+++++ + L ++KD L+K+ D KN + ++E +K + L K
Sbjct: 841 LQKVKMEKEALMTELSTVKDKLSKVS-------DSLKNSKSEFEKENQKGKAAILDLEKT 893
Query: 533 FKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRE----RDELI---GKLKSEEEK 585
K + ++ E ++E K+L K + +E + L E +++LI LK E++
Sbjct: 894 CKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
Query: 586 SSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKE-LTLEIERLKKRLQ 644
+L +++ LK+ + ++ + E +G + +NK+++ LT + L +
Sbjct: 954 EQQLQGNINELKQSSEQ-KKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE 1012
Query: 645 QLEVVEGDLMKTEDEYDQLEQKF--------------RTEQDKANFLSQQLEEIKHQIA- 689
++ V++ + K+++ + QL+ F ++ ++K + + L ++QI
Sbjct: 1013 KISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072
Query: 690 KNKAIEK----GEVVSQEAELRHRFRLEEAKS-RDLKAEVQALKEKIHELMNKEDQLSQL 744
+NK I++ + Q++ + + E K+ +D++ E ++LKEK EL+N++ +L+++
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE-KSLKEK--ELVNEKSKLAEI 1129
Query: 745 QVDYSVLQQR---FMEEENKNKNMG--QEVLNLTKELELSKRYSRALRPSVNG-RRMVDV 798
+ + Q++ + EE K+ + +E+ NL +L + L+ + + V+
Sbjct: 1130 E-EIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ 1188
Query: 799 PVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERSSVLDRYPP 858
+ + D V E EEE FI K + + I ++VG+KK E + L
Sbjct: 1189 EKRNQQILKDQVKKE--EEELKKEFIEKEAKLHSEIKE--KEVGMKKHEENEAKLTMQIT 1244
Query: 859 AANEL--TMRKSW 869
A NE T++K W
Sbjct: 1245 ALNENLGTVKKEW 1257
Score = 115 bits (287), Expect = 3e-25
Identities = 171/825 (20%), Positives = 359/825 (43%), Gaps = 99/825 (12%)
Query: 33 SEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKS---LELSKEDLIQLLSIMEG 89
S AK ++ N E + G + ++ +K+K++ LE +EDL + EG
Sbjct: 499 STTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEG 558
Query: 90 E---LQAREDVIHMLK------TEKTKPEVLEAH-------YGSAEPEKVLRVLHRDAIL 133
E L ++ H L+ TEK K + E+H + + +K +D +L
Sbjct: 559 ETAVLNQLQEKNHTLQEQVTQLTEKLKNQS-ESHKQAQENLHDQVQEQKAHLRAAQDRVL 617
Query: 134 AQEKSIGE-----DVYEKPISELDRLEEKQKETYRRMLEQLLLAEKC----HRRTVYE-L 183
+ E S+ E + ++ +S+LD ++ K K E A++ H T L
Sbjct: 618 SLETSVNELNSQLNESKEKVSQLD-IQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNAL 676
Query: 184 ENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQAR------KEKENAKRLNKLR 237
++++ + + D T L+ ++E +L K Y+ + K +E ++ KL
Sbjct: 677 QDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE 736
Query: 238 DELVKLKSF---ALM-LVDERQMHIE----------QLGLQSQKVQDLTQKLREEEEKLK 283
+ +++K+ AL L +RQ++ + QL ++ + V L+++ E L+
Sbjct: 737 ADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALE 796
Query: 284 AITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIE 343
+I K + ++ L+ DFE + +HEE+N ++ + ++++++ L +
Sbjct: 797 SIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEAL---MT 853
Query: 344 ELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDE-EITKTES 402
EL L K + L+ + + K N A + +L K E++ + + ++ T
Sbjct: 854 ELSTVKDKLSKVSDSLKNSKSEFEKE---NQKGKAAILDLEKTCKELKHQLQVQMENTLK 910
Query: 403 QCRELRKKLQEEEHHSKELRLEVEKLQKRMSE----LEKLEEAFSKSKSECTQLHLNLEK 458
+ +EL+K L++E+ S +L+LE+ +Q+++ + L++ E+ + + +L + E+
Sbjct: 911 EQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQ 970
Query: 459 EKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEK 518
+K + L EL++ + ELE ++L++ +L K +L + + E
Sbjct: 971 KKKQIEALQGELKIAVLQKTELE---NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027
Query: 519 IKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEM--------EEKVYNLTR 570
KQ + G + + V EKL + L+ ++++ E K T
Sbjct: 1028 FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL 1087
Query: 571 ERD------ELIGKLKSEEEKSSELSCSVDLL---KKRLDGIEEVEREITRGRSRKGSEL 621
E+D +L + K+ ++ E S L K +L IEE++ + ++ EL
Sbjct: 1088 EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL 1147
Query: 622 TCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQL 681
+ IKE+T + + +QQ ++G K + +EQ+ R +Q + + ++
Sbjct: 1148 KSHKLESIKEITNLKDAKQLLIQQKLELQG---KADSLKAAVEQEKRNQQILKDQVKKEE 1204
Query: 682 EEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQL 741
EE+K + + +A E+ +E ++ E L ++ AL E L
Sbjct: 1205 EELKKEFIEKEAKLHSEIKEKEVGMKK----HEENEAKLTMQITALNE----------NL 1250
Query: 742 SQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRAL 786
++ ++ Q+R E E + ++ E+ L ++ ++ RAL
Sbjct: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL 1295
Score = 81.3 bits (199), Expect = 5e-15
Identities = 110/554 (19%), Positives = 235/554 (42%), Gaps = 55/554 (9%)
Query: 37 KKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKK--SLELSKEDLIQLLSIMEGELQAR 94
+++K+ +++ + ++ T +H + + + + +++ KE L+ LS ++ +L
Sbjct: 806 EEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKV 865
Query: 95 EDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRL 154
D + K+E K E + + EK + L + E ++ E EL +
Sbjct: 866 SDSLKNSKSEFEK-ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ------KELKKS 918
Query: 155 EEKQKETYRR-------MLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQE 207
EK+KE + M EQL+ A+ + +NEK + N N L+Q
Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQNTLK------QNEKEEQQLQGN-----INELKQS 967
Query: 208 RERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQK 267
E+ KK +E + + + NKL+ +L + ++L + +K
Sbjct: 968 SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAA--------------QELAAEKEK 1013
Query: 268 VQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEM---NAKLANQ 324
+ L + +E K + S +LL D + + S E++ ++ NQ
Sbjct: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ 1073
Query: 325 ESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLR 384
++L+ L Q + E+ + KA +++Q+ + K S +AE+E ++
Sbjct: 1074 NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK 1133
Query: 385 KRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELR-LEVEKLQKRMSELEKLEEAFS 443
R +++EITK + + + + +E + K+ + L +++ + + + L+ A
Sbjct: 1134 CR------QEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVE 1187
Query: 444 KSKSECTQLHLNLEK-EKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLK 502
+ K L ++K E+ L K+ + + + S +KE E + E+ E L +T L
Sbjct: 1188 QEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALN 1247
Query: 503 SFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEME 562
+ E ++ ++ + E++ D L V + V + ++ ++ LK + E+E
Sbjct: 1248 ENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIE 1307
Query: 563 E---KVYNLTRERD 573
+ KV L R+ D
Sbjct: 1308 KLQTKVLELQRKLD 1321
Score = 65.9 bits (159), Expect = 2e-10
Identities = 85/408 (20%), Positives = 172/408 (42%), Gaps = 43/408 (10%)
Query: 36 AKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQAR- 94
A+ K N KE+ + LK S E ++K ++L+ + + + +E +LQ +
Sbjct: 943 AQNTLKQNEKEEQQLQGNI--NELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000
Query: 95 EDVIHMLKTEKTKPEVLEAHYG-SAEPEKVLR--VLHRDAILAQEKSIGEDVYEK-PISE 150
L EK K VL+ +Y S E K L+ R++ L + + V EK +++
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQ 1060
Query: 151 LDRLEEK-QKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERE 209
D + + Q +++++L A+ + + E + + + +L E+E
Sbjct: 1061 EDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELV 1120
Query: 210 RLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQ 269
K L + + + R+EKE K +L+ ++ L D +Q+ I+Q K
Sbjct: 1121 NEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKAD 1180
Query: 270 DLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNR 329
L + +E+ + + + K++ ++L K +F K ++ E +E + E +
Sbjct: 1181 SLKAAVEQEKRNQQILKDQVKKEEEELKK---EFIEKEAKLHSEIKEKEVGMKKHEENEA 1237
Query: 330 QLRLKLVGLTQ--------------RIEELEETNKNL-----------QKAEEELQELRD 364
+L +++ L + R+ ELE+ +L Q ++E + L +
Sbjct: 1238 KLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLE 1297
Query: 365 KIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQ 412
+ KGE E+E L+ +VLE++ K + T + + LQ
Sbjct: 1298 RCLKGE-------GEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 124 bits (310), Expect = 7e-28
Identities = 199/941 (21%), Positives = 396/941 (42%), Gaps = 136/941 (14%)
Query: 34 EDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQA 93
E A K++ + +D++ S ++ L+ K K L+L + + S+ + E +
Sbjct: 851 EMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQS--EADSLADAEERC 908
Query: 94 REDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDR 153
+ + + ++ E EV E AE E+ + +A L +K ED + ++D
Sbjct: 909 EQLIKNKIQLEAKIKEVTER----AEEEEEI-----NAELTAKKRKLEDECSELKKDIDD 959
Query: 154 LE------EKQKETYRRMLEQLLLAEKCHRRTVYELENEK------HKHT-DYMNKSDDF 200
LE EK+K ++ L T+ +L EK H+ T D + +D
Sbjct: 960 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDK 1019
Query: 201 TNLL-------EQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDE 253
N+L EQ+ + L+ LEQEK + R + E AKR KL + L L E
Sbjct: 1020 VNILTKAKTKLEQQVDDLEGSLEQEK--KLRMDLERAKR--KLEGD--------LKLAQE 1067
Query: 254 RQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQE 313
M +E Q L +KL ++E ++ + SK ++++ ++L+ + +R +
Sbjct: 1068 STMDME------NDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEEL 1121
Query: 314 HEEMNAKLANQ---ESHNRQLRLKLVGLTQRIEEL-------EETNKNLQKAEEELQELR 363
EE+ A+ A++ E L +L +++R+EE E NK K E E Q+LR
Sbjct: 1122 GEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNK---KREAEFQKLR 1178
Query: 364 DKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRL 423
+ + + +++A + +K M E+I + ++L K+ E + + +L
Sbjct: 1179 RDLEEATLQHEAMVAALR--KKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSS 1236
Query: 424 EVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECS 483
E + K LEK+ + SE L+ ++ + L+N+L ++R++
Sbjct: 1237 NAEAISKAKGNLEKMCRSLEDQVSE-------LKTKEEEQQRLINDLTAQRARLQTEAGE 1289
Query: 484 ESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEK-----------IKQEERKVDGLNKN 532
SR + +L L++ K + ++E K+ +E+ ++ D L +
Sbjct: 1290 YSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQ 1349
Query: 533 FKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSE---- 588
++ EQ ++ L + + ++ + +++ E T E +E KL +++ E
Sbjct: 1350 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEA 1409
Query: 589 ---LSCSVDLLKKRLDG-IEEVEREITRG---------RSRKGSELTCPEDNKIKELTLE 635
S++ K+RL +E++ ++ R + R ++ K +E E
Sbjct: 1410 VNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAE 1469
Query: 636 IERLKKRLQQLEVVEGDLMKTEDEY----DQLEQKFRTEQDKANFLS------------- 678
+E +K + L +L K ++ Y DQLE R ++ +S
Sbjct: 1470 LEASQKESRSLST---ELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQI 1526
Query: 679 QQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKI-HELMNK 737
+LE+IK Q+ + K + + EA L H EE K ++ E+ +K ++ ++ K
Sbjct: 1527 HELEKIKKQVEQEKCEIQAALEEAEASLEH----EEGKILRIQLELNQVKSEVDRKIAEK 1582
Query: 738 EDQLSQLQVDYSVL---QQRFMEEENKNKNMGQEVLNLTK----ELELSKRY-SRALRPS 789
++++ QL+ +++ + Q ++ E +++N V + E+E+ + +R S
Sbjct: 1583 DEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAES 1642
Query: 790 VNGRRMVDVPVTSTGVQ-TDAVSGEAAEEETPAVFIRKS---FQEENHIMSNLRQVGLKK 845
+ R + T + DA+ G+ +E A+ R++ E + + L Q +
Sbjct: 1643 LRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSR 1702
Query: 846 PVERSSVLDRYPPAANELTMRKSWIPWMRKRENGPSITQEK 886
+ +LD T S I +K EN S Q +
Sbjct: 1703 KIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSE 1743
Score = 122 bits (305), Expect = 3e-27
Identities = 195/866 (22%), Positives = 360/866 (41%), Gaps = 142/866 (16%)
Query: 68 KTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEV-LEAHYGSAEPEKVLRV 126
K KK+L+ + + + +LQA ED +++L KTK E ++ GS E EK LR+
Sbjct: 997 KEKKALQETHQQTLD-------DLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRM 1049
Query: 127 --------LHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLE---------QL 169
L D LAQE ++ + ++ + E +LE+K+ E + + QL
Sbjct: 1050 DLERAKRKLEGDLKLAQESTMDMENDKQQLDE--KLEKKEFEISNLISKIEDEQAVEIQL 1107
Query: 170 LLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKEN 229
K + + EL E K++ + L +E E + + LE+ + + + N
Sbjct: 1108 QKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELN 1167
Query: 230 AKR---LNKLRDELVKLK-SFALMLVDERQMHIE---QLGLQSQKVQDLTQKLREEEEKL 282
KR KLR +L + M+ R+ H + +LG Q +Q + QKL +E+ +L
Sbjct: 1168 KKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSEL 1227
Query: 283 KAITS------------------------------KSKEDRQKLLKLEVDFEHKASRFSQ 312
K T K+KE+ Q+ +L D + +R
Sbjct: 1228 KMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQ--RLINDLTAQRARLQT 1285
Query: 313 EHEEMNAKLANQESHNRQLRLKLVGLTQRIEEL-----EETN-KN-----LQKAEEELQE 361
E E + +L +++ QL TQ+IEEL EET KN LQ + +
Sbjct: 1286 EAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDL 1345
Query: 362 LRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDE-----EITKTESQCRELRKKLQEEEH 416
LR++ + + G + L + V + K E + E ++L ++LQE E
Sbjct: 1346 LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE 1405
Query: 417 HSKELRLEVEKLQKR----MSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEV 472
H + + + L+K +E+E L +S + C L +K++N K L +
Sbjct: 1406 HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALD---KKQRNFDKVLSEWKQK 1462
Query: 473 VKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKN 532
+ ELE S +K SL +L K+K+ + +E + +E +++E NKN
Sbjct: 1463 YEETQAELEAS----QKESRSLSTELFKVKN----VYEESLDQLETLRRE-------NKN 1507
Query: 533 FKVEQGKVMDVTEKLIEESK---KLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSEL 589
Q ++ D+TE++ E K +L K+K ++E++ + +E L+ EE K +
Sbjct: 1508 L---QQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRI 1564
Query: 590 SCSVDLLKKRLD-GIEEVEREI---TRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQ 645
++ +K +D I E + EI R +R + D +I+ + R+KK++
Sbjct: 1565 QLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRN-DALRVKKKM-- 1621
Query: 646 LEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAE 705
EGDL + E + + + + N+ + Q I K + + + + +
Sbjct: 1622 ----EGDLNEMEIQLNHANR--LAAESLRNYRNTQ------GILKETQLHLDDALRGQED 1669
Query: 706 LRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEE----NK 761
L+ + + E ++ L+AE++ L + + Q +D S Q + N
Sbjct: 1670 LKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT 1729
Query: 762 NKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGE---AAEEE 818
K + +V L E+E ++ S N +T + + + E +A E
Sbjct: 1730 KKKLENDVSQLQSEVE------EVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1783
Query: 819 TPAVFIRKSFQEENHIMSNLRQVGLK 844
+ ++ ++ H + Q+ LK
Sbjct: 1784 RMKKNLEQTVKDLQHRLDEAEQLALK 1809
Score = 117 bits (293), Expect = 7e-26
Identities = 163/786 (20%), Positives = 342/786 (43%), Gaps = 112/786 (14%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDL---IQLLS 85
E +L +A + D + G +L+ + K K L++ +DL + +S
Sbjct: 1183 EATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAIS 1242
Query: 86 IMEGELQ----AREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGE 141
+G L+ + ED + LKT++ + + L + R A E S
Sbjct: 1243 KAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRA--------RLQTEAGEYSRQL 1294
Query: 142 DVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFT 201
D + +S+L R ++ + + QL K + L++ +H + ++
Sbjct: 1295 DEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQ 1354
Query: 202 NLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQL 261
+ + L K + ++ + E + +R +L + KL + E + H+E +
Sbjct: 1355 EGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ----RLQEAEEHVEAV 1410
Query: 262 GLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKL 321
+ ++ Q+L+ E E L +S L K + +F+ S + Q++EE A+L
Sbjct: 1411 NAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAEL 1470
Query: 322 ANQESHNRQLRLKLVGL-------TQRIEELEETNKNLQKAEEELQELRDKIAKGECGNS 374
+ +R L +L + ++E L NKNLQ +E+ +L ++IA+G
Sbjct: 1471 EASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQ---QEISDLTEQIAEG----G 1523
Query: 375 SLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEV--------E 426
+ E+E ++K+V ++E + ++ E L+ EE ++LE+
Sbjct: 1524 KQIHELEKIKKQV------EQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1577
Query: 427 KLQKRMSELEKL--------EEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVK 478
K+ ++ E+++L E S +E + L +K + D LNE+E+ +
Sbjct: 1578 KIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGD-LNEMEIQLNHAN 1636
Query: 479 ELECSESR--------LEKAELSLKDDLTKLKSF--TVMLVDERKNMME-KIKQEERKVD 527
L R L++ +L L D L + + +V+ R N+++ +I++ ++
Sbjct: 1637 RLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLE 1696
Query: 528 GLNKNFKVEQGKVMDVTEK---LIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEE 584
++ K+ + +++D +E+ L ++ L+ K ++E V L E +E+I + ++ EE
Sbjct: 1697 QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEE 1756
Query: 585 KS-----------------SELSCSVDLLKKRLD--------GIEEVEREITRGRSRKGS 619
K+ + S ++ +KK L+ ++E E+ +G ++
Sbjct: 1757 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ 1816
Query: 620 ELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQ 679
+L + +++EL E+E +KR E V+G L K E +L ++TE+D+ N L
Sbjct: 1817 KL----EARVRELEGEVENEQKR--NAEAVKG-LRKHERRVKEL--TYQTEEDRKNVLRL 1867
Query: 680 Q--LEEIKHQIA--KNKAIEKGEV----VSQEAELRHRFRLEEAKSRDLKAEVQALKEKI 731
Q +++++ ++ K +A E E +S+ +L+H E ++ +++V L+ K
Sbjct: 1868 QDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKS 1927
Query: 732 HELMNK 737
E+ K
Sbjct: 1928 REVHTK 1933
Score = 107 bits (268), Expect = 5e-23
Identities = 146/664 (21%), Positives = 288/664 (43%), Gaps = 77/664 (11%)
Query: 189 KHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKE---KENAKRLNKLRDELVKLKS 245
KH +M LL+ E K++ ++ +Q K+ K AKR +L +++V L
Sbjct: 828 KHWPWMKLFFKIKPLLKSA-ETEKEMATMKEEFQKTKDELAKSEAKR-KELEEKMVTLLK 885
Query: 246 FALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQ---KLLKLEVD 302
L + Q + L ++ + L + + E K+K +T +++E+ + +L +
Sbjct: 886 EKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRK 945
Query: 303 FEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQEL 362
E + S ++ +++ LA E K+ LT+ + L+ET L K ++ LQE
Sbjct: 946 LEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQET 1005
Query: 363 R----DKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHS 418
D + E + L L ++V ++EG E+ K ++KL+
Sbjct: 1006 HQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE------ 1059
Query: 419 KELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVK 478
+L+L E ++ ++L+E K + E + L +E E+ + L +++ +++R++
Sbjct: 1060 GDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIE 1119
Query: 479 EL-------ECSESRLEKAELSLKDDLTKLK----------SFTVMLVDERKNMMEKIK- 520
EL S ++ EK L +L ++ S V L +R+ +K++
Sbjct: 1120 ELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRR 1179
Query: 521 -------QEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERD 573
Q E V L K ++ + + L +KL K KSE++ + +L+
Sbjct: 1180 DLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLS-SNA 1238
Query: 574 ELIGKLKSEEEK-SSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSEL------TCPED 626
E I K K EK L V LK + + + + ++T R+R +E +D
Sbjct: 1239 EAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKD 1298
Query: 627 NKIKEL-------TLEIERLKKRLQQ----LEVVEGDLMKTEDEYDQLEQKFRTEQDKAN 675
+ +L T +IE LK +L++ + L + + D L +++ EQ+
Sbjct: 1299 ALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKA 1358
Query: 676 FLSQQLEEIKHQIA------KNKAIEKGEVVSQEAELRHRFRLEEAKS--RDLKAEVQAL 727
L + L + ++A + AI++ E + +EA+ + RL+EA+ + A+ +L
Sbjct: 1359 ELQRALSKANSEVAQWRTKYETDAIQRTEEL-EEAKKKLAQRLQEAEEHVEAVNAKCASL 1417
Query: 728 KEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKN-----KNMGQEVLNLTKELELSKRY 782
++ L N+ + L L V+ S ++++ +N Q+ ELE S++
Sbjct: 1418 EKTKQRLQNEVEDL-MLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKE 1476
Query: 783 SRAL 786
SR+L
Sbjct: 1477 SRSL 1480
Score = 68.2 bits (165), Expect = 5e-11
Identities = 116/564 (20%), Positives = 227/564 (40%), Gaps = 97/564 (17%)
Query: 71 KSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRD 130
+ LE +K+ L Q L E ++A L EKTK + E E ++ + R
Sbjct: 1387 EELEEAKKKLAQRLQEAEEHVEAVNAKCASL--EKTKQRLQN------EVEDLMLDVERS 1438
Query: 131 AILAQEKSIGEDVYEKPISELDR--------LEEKQKETYRRMLEQLLLAEKCHRRTVYE 182
+ ++K +SE + LE QKE+ R + +L + + ++ +
Sbjct: 1439 NAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKES-RSLSTELFKVKNVYEESLDQ 1497
Query: 183 LENEKHKHTDYMNKSDDFTNLLEQ------ERERLKKLLEQEKA-YQARKEKENAK---- 231
LE + ++ + + D T + + E E++KK +EQEK QA E+ A
Sbjct: 1498 LETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHE 1557
Query: 232 --RLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKS 289
++ +++ EL ++KS + E+ I+QL +V + Q + E + + +
Sbjct: 1558 EGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRV 1617
Query: 290 KEDRQ-KLLKLEVDFEHKASRFSQE---------------HEEMNAKLANQESHNRQLRL 333
K+ + L ++E+ H A+R + E ++ L QE QL +
Sbjct: 1618 KKKMEGDLNEMEIQLNH-ANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAI 1676
Query: 334 --KLVGLTQ-RIEEL----EETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKR 386
+ L Q IEEL E+T ++ + AE+EL + +++ N+SL+ + L
Sbjct: 1677 VERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLEND 1736
Query: 387 VLEMEGKDEEITKTESQCRELRKK-----------LQEEEHHSKEL-------------- 421
V +++ + EE+ + E KK L++E+ S L
Sbjct: 1737 VSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1796
Query: 422 ---------------RLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDL 466
+ +++KL+ R+ ELE E K +E + L K + K+L
Sbjct: 1797 QHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVK---GLRKHERRVKEL 1853
Query: 467 LNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKV 526
+ E + V L+ +L+ S K + + + + + + + ++++ E +
Sbjct: 1854 TYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERA 1913
Query: 527 DGLNKNFKVEQGKVMDVTEKLIEE 550
D + K +V K+ E
Sbjct: 1914 DIAESQVNKLRVKSREVHTKISAE 1937
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 123 bits (308), Expect = 1e-27
Identities = 154/727 (21%), Positives = 323/727 (44%), Gaps = 83/727 (11%)
Query: 104 EKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYR 163
EK +VLE E + RD + G+ EK E +RL K++Y
Sbjct: 4 EKGGKQVLE--------ESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYD 55
Query: 164 RMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQA 223
E+ L+A KC + N T DD T + ++E K + AY
Sbjct: 56 N--EKRLMA-KCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD- 111
Query: 224 RKEKENAKRLNKLRDELVKLKSFALM---LVDERQMHIEQLGLQSQKVQDLTQKLREEEE 280
KE++ + + L++E+V L L ++ +I L ++V +L E
Sbjct: 112 -KEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVV 170
Query: 281 KLKAITSKSKEDRQKLLKLEVDFEHKASRFSQE----HEEMNAKLANQESHNRQLRLKLV 336
KL+ +++ E +Q+ + + + EH S+F QE E + + +E ++L+
Sbjct: 171 KLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQA 230
Query: 337 GLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKR---------- 386
+ R E++ + +QK++EELQ+L ++ + + N E+E + R
Sbjct: 231 DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQ 290
Query: 387 ---------------VLEMEGKDEEITKTE---SQCRELRKKLQEEEHHSKELRLEVEK- 427
LE++ K+EE+ + + ++R+++ ++ HH+++ + EVE+
Sbjct: 291 HSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH 350
Query: 428 ---LQKRMSELEKLEEAFSKSKSECTQLHLN--LEKEKNLTKDLLNELEVVKSR---VKE 479
L+ ++ LE+ EA SK ++E + ++ L + L K++L + + + VK
Sbjct: 351 KETLKNQIVGLEREVEA-SKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKL 409
Query: 480 LECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGK 539
E ++ LE + KD+ K + L ER + + +KV ++ KV + +
Sbjct: 410 HEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQ 469
Query: 540 VMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGK-LKSEEEKSSELSCSVDLLKK 598
+ D +K+ E ++K + ++ +Y R L K L +++ +++ + ++
Sbjct: 470 IFDYRKKIAES-----EIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIH 524
Query: 599 RLDGIEE---------VEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVV 649
++D ++E V+ + + R K E E K+++ LE K +++ E
Sbjct: 525 QVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALE---TKHFIEKQEAE 581
Query: 650 EGDLMK--TEDEYDQLEQKFRTEQ--DKANFLSQQLEEIKHQIA-KNKAIEKGEVVSQEA 704
E L++ E + ++L QK +Q + + L QL ++A + I+ + V +
Sbjct: 582 ERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKG 641
Query: 705 ELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKN 764
E ++ RLE+ R L+ E++ L+ + L + +L+ ++ +Q+ ++E + +
Sbjct: 642 ESQYNQRLED--MRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRA 699
Query: 765 MGQEVLN 771
+ +E+ N
Sbjct: 700 LEEELEN 706
Score = 109 bits (272), Expect = 2e-23
Identities = 164/772 (21%), Positives = 344/772 (44%), Gaps = 62/772 (8%)
Query: 46 EDDVMASGTVKRHLKTSGEC-------ERKTKKSLELSKEDLIQLLSIME-GELQAREDV 97
+DD ++K+ ++ + + E+K K+++ KE+++ L ++E G + +
Sbjct: 86 QDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQH 145
Query: 98 IHMLKTEKTKPEVL-EAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDR-LE 155
++ + K EV E +E K+ L + QE ++ E IS+ + ++
Sbjct: 146 SNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQ 205
Query: 156 EKQKETYR--RMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQE------ 207
++Q E R R E+L K + + + E Y+ KS + LEQ+
Sbjct: 206 QRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKI 265
Query: 208 -RERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQ 266
ER K LEQ + A+ ++EN + + + ++L + + + ++ + Q+ L
Sbjct: 266 LNERAAKELEQFQMRNAKLQQENEQH-SLVCEQLSQENQQKALELKAKEEEVHQMRLDIG 324
Query: 267 KV----QDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLA 322
K+ + + +KL E++ + + + +++ LE + E + + + M+ L
Sbjct: 325 KLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLR 384
Query: 323 NQESHNRQLRLKLVGLTQRIEEL----EETNKNL----QKAEEELQELRDKIAKGECGNS 374
++ N+ + LK V TQ+ +L E+ +NL Q ++E Q+ R I E
Sbjct: 385 ERDILNKNM-LKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERD 443
Query: 375 SLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSE 434
+ + +L ++VL E+I E+Q + RKK+ E E K+ + E ++ S+
Sbjct: 444 RYINQASDLTQKVLM---NMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVR---SD 497
Query: 435 LEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSL 494
+ +++ E T + L+ + +L ++ +S + +L + R+EK + +L
Sbjct: 498 RNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETL 557
Query: 495 KDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKL 554
K +L KL+ + E K+ +EK + EERK+ + + + + + + K+L
Sbjct: 558 KAELQKLRQQAL----ETKHFIEKQEAEERKLLRI----------IAEADGERLRQKKEL 603
Query: 555 LKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGR 614
++ SE + L R DEL + + + S L+ +RL+ + + EI + R
Sbjct: 604 DQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLR 663
Query: 615 SRKG---SELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQ 671
KG + E+ + + ++ E LK+R + +E +L + + +K
Sbjct: 664 REKGILARSMANVEELRQEFFHMQRELLKER-TRCRALEEELENPLNVHRW--RKLEASD 720
Query: 672 DKANFLSQQLEEI-KHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAE-VQALKE 729
A L Q++ + K I+K + + + E++ QE E + L+ +R E + LK
Sbjct: 721 PNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLY-MELKHVLARQPGPEAAEQLKL 779
Query: 730 KIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKR 781
L +K+ QL L + ++ + + E + + + + E+ NL K+ KR
Sbjct: 780 YRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKR 831
Score = 85.5 bits (210), Expect = 3e-16
Identities = 129/636 (20%), Positives = 263/636 (41%), Gaps = 79/636 (12%)
Query: 33 SEDAKKKKKSNRKEDDVMASGTVK-------RHLKTSGECERKTKKSLELSKEDLIQLLS 85
S++ +K + KE ++ K R+ K E E+ + +LS+E+ + L
Sbjct: 249 SKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKAL- 307
Query: 86 IMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYE 145
EL+A+E+ +H ++ + K + E++ + LH E ++ +
Sbjct: 308 ----ELKAKEEEVHQMRLDIGKLNKIR--------EQIHKKLHHTEDQKAEVEQHKETLK 355
Query: 146 KPISELDRLEE---KQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTN 202
I L+R E KQ E R+ +++LL + + + N K TD + +
Sbjct: 356 NQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKR 415
Query: 203 LLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLG 262
LE E + K ++++ EKE + +N+ D K+ LM +++ ++ Q+
Sbjct: 416 NLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKV----LMNMEDIKVRETQIF 471
Query: 263 LQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLE---VDFEHKASRFSQEHEEMNA 319
+K+ + KL++++ +A+ S + L++ + D + K + +E+
Sbjct: 472 DYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKE 531
Query: 320 KLANQESHNRQLRLKLVGLTQRIEELEETNK-NLQKAEEELQELRDKIAKGECGNSSLM- 377
++ +ES +L L+ QRIE+ +ET K LQK ++ E + I K E L+
Sbjct: 532 DISAKESALVKLHLE----QQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLR 587
Query: 378 ----AEVENLRKR------VLEMEGKDEEITKTESQCRELRKKLQEEE------------ 415
A+ E LR++ + E + ++ + + L +K++ ++
Sbjct: 588 IIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQ 647
Query: 416 --HHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELE-- 471
+ LRLE++KL++ L + + + E + L KE+ + L ELE
Sbjct: 648 RLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENP 707
Query: 472 VVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNK 531
+ R ++LE S+ + + +L S T +V++ + EK K L +
Sbjct: 708 LNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLAR 767
Query: 532 NFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSC 591
E + + + + + + K+ LK+ L +L E +S E
Sbjct: 768 QPGPEAAEQLKLYRRTLHDKKQQLKV-----------------LSSELNMYEVQSKEYKY 810
Query: 592 SVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDN 627
V+ L L +++ R + ++ T P DN
Sbjct: 811 EVEKLTNELQNLKKKYLAQKRKEQLQKNKDTAPMDN 846
Score = 60.1 bits (144), Expect = 1e-08
Identities = 81/386 (20%), Positives = 170/386 (44%), Gaps = 59/386 (15%)
Query: 426 EKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSES 485
+ L+K E E+L KS +L + K + L +++ V + +K + ++
Sbjct: 34 KSLEKFRIEYERLHAVMKKSYDNEKRL---MAKCRELNAEIVVNSAKVATALKLSQDDQT 90
Query: 486 RLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTE 545
+ SLK ++ K D+ + E I + ++ L K VEQG + + +
Sbjct: 91 TIA----SLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTK--LVEQGSGLSMDQ 144
Query: 546 KLIEESKKLLKLKSEMEEKVYNLTRERDELIG---KLKSEEEKSSELSCSVDLLKKRLD- 601
+ LL+ K E+ T+ERD+L+ KL+ +++E + K+ +
Sbjct: 145 H--SNIRDLLRFKEEV-------TKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEH 195
Query: 602 GIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYD 661
I + ++EI + ++ E + E+L+K L+Q ++ D+ + E
Sbjct: 196 AISQFQQEIQQRQNEASREFR------------KKEKLEKELKQ---IQADMDSRQTEIK 240
Query: 662 QLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLK 721
L+Q + +++ L QQL+E K I +A ++ E + ++R+ +E + L
Sbjct: 241 ALQQYVQKSKEELQKLEQQLKEQK--ILNERAAKELE----QFQMRNAKLQQENEQHSLV 294
Query: 722 AEV--QALKEKIHELMNKEDQLSQLQVDYSVL--------------QQRFMEEENKNKNM 765
E Q ++K EL KE+++ Q+++D L + + E E + +
Sbjct: 295 CEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETL 354
Query: 766 GQEVLNLTKELELSKRYSRALRPSVN 791
+++ L +E+E SK+ + R +++
Sbjct: 355 KNQIVGLEREVEASKKQAELDRKAMD 380
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 122 bits (307), Expect = 2e-27
Identities = 174/773 (22%), Positives = 355/773 (45%), Gaps = 98/773 (12%)
Query: 36 AKKKKKSNRKEDDVMASG----TVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGEL 91
AKK +K R+E+ + G VK L E + +++L+ +++L Q L +E ++
Sbjct: 1666 AKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDM 1725
Query: 92 QAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVL-----RVLHRDAILAQEKSIGEDVYEK 146
+ L E+ K ++E AE E+ L ++ + LAQE+ + EK
Sbjct: 1726 EELSWKEEELNQEEGK--LVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEK 1783
Query: 147 PISELDRLEEKQKETYRRMLEQLL-----LAEKCHRRTVYELENEKHKHTDYMNKSDDFT 201
+++ E+++ R+ EQL+ LA+K R E K+K Y K+
Sbjct: 1784 LAQHKEKMPEEEERLGRKR-EQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKN---- 1838
Query: 202 NLLEQERERLKKLLEQEKAYQARKEK--ENAKRLNKLRDELVKLKSFALMLVDERQMHIE 259
L QE++ L + E+EK Q RKE N +RL + +LV++K+
Sbjct: 1839 --LAQEKKNLAQ--EKEKLAQ-RKENLLYNKERLTHSKKQLVQVKN-------------- 1879
Query: 260 QLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNA 319
+LG+ ++ + + +KL +E+E + K E +KL+++E K + +QE ++
Sbjct: 1880 KLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLAL 1939
Query: 320 KLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAE 379
+ A + R LR +L + + + L K L + + L E ++ ++KGE +S
Sbjct: 1940 EKAMVQGKKR-LRGEL-DIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETS---- 1993
Query: 380 VENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEE--HHSKELRLEVEKLQKRMSELEK 437
+ ++T+ E + E + L+E+ H + L +E ++ K E +
Sbjct: 1994 -------------RQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTR 2040
Query: 438 LEEAFSKSKSECTQLHLNL-EKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKD 496
+ F + + + + L +K ++L+K+ +++K+ +++L E +L + E+ +
Sbjct: 2041 GQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKA-LQKLTRDERKLTQEEIKM-- 2097
Query: 497 DLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKV--EQGKVMDVTEKLIEESKKL 554
TK+K + V ER+ +E+ K + ++ D K ++ ++ K+ KL + +++
Sbjct: 2098 --TKMKR--ALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRM 2153
Query: 555 LKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGR 614
+ + +M E+ L R+ E+I L EEE E + LK+R +E +R
Sbjct: 2154 INKEEKMTEEESKLARKHSEVI--LDDEEEGGIEEEEVIPFLKRRWRKRKEAKR------ 2205
Query: 615 SRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKA 674
K E + ++++ E ++ L +LE E + +E+E ++ E++ R E
Sbjct: 2206 GDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQES--LSSEEEEEREEEEEREE---- 2259
Query: 675 NFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHEL 734
EE++ + + K E+GE E E + + ++ K ++ E + + E+ E+
Sbjct: 2260 -------EEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEI 2312
Query: 735 MNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALR 787
M++E+ S + EE ++ K E+L K+ +L ++ ++LR
Sbjct: 2313 MSEEETESLSDEEEEEESCSLEEEVDREK----EILKKEKQFKLQEQRRKSLR 2361
Score = 118 bits (296), Expect = 3e-26
Identities = 170/807 (21%), Positives = 363/807 (44%), Gaps = 71/807 (8%)
Query: 34 EDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQA 93
E +KK++K ++ V++ K TK+ ++S+E ++ ++ +E ++
Sbjct: 1386 EISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEE--VEEMATLEEKVVK 1443
Query: 94 REDVIHMLKT-------EKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEK 146
+E + M++ +K E + H + + K + +L +E+ + + EK
Sbjct: 1444 QEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQ-AGEK 1502
Query: 147 PISELDRLEEKQK---ETYRRMLEQLLLAE------KCHRRTVYELENEKHKHTDYMNKS 197
E + L+E +K E ++++ E +L ++ K E E + +
Sbjct: 1503 LSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVT 1562
Query: 198 DDFTNLLEQ--------ERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKL-KSFAL 248
++ ++ E+ +R R +K QE+ A++E++ A+ +L E KL +++
Sbjct: 1563 EEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVK 1622
Query: 249 MLVDERQM---------HIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKL 299
+ D+R+M E L + +K+ +KL ++ +KL K + +KL K
Sbjct: 1623 ITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKK 1682
Query: 300 EVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEEL 359
+ +Q+ EE+ + N + ++L +L L +EEL + L + E +L
Sbjct: 1683 GGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKL 1742
Query: 360 QELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSK 419
E + K+A+ E +L + E L + ++ ++E + + + + + ++K+ EEE +
Sbjct: 1743 VEEKKKLAEEE---EALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEE---E 1796
Query: 420 ELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLT---KDLLNELEVVKSR 476
L + E+L ++ +L + E + S E T+ + L ++KNL K+L E E + R
Sbjct: 1797 RLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQR 1856
Query: 477 VKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVE 536
+ L ++ RL ++ L KL F +L + EK+ QE+ V +
Sbjct: 1857 KENLLYNKERLTHSKKQLVQVKNKLGMFNKILA----QVEEKLTQEKETVIKKKEKLAET 1912
Query: 537 QGKVMDVTEKLIEESKKLL--KLKSEMEE-KVYNLTRERDELIGKLKSEEEKSSELSCSV 593
+ K++ V + L ++ +KL K+K +E+ V R R EL K E+ + E+
Sbjct: 1913 EKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGEL-DIAKEEKALNLEMKRLA 1971
Query: 594 DLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDL 653
+ + ++G E + + T SR+ ++ ++L+LE + L + L + E ++
Sbjct: 1972 EEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEI 2031
Query: 654 MKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKN--------KAIEK-----GEVV 700
K + E+ + ++ F Q K S++L + + ++K KA++K ++
Sbjct: 2032 AKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLT 2091
Query: 701 SQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEEN 760
+E ++ R K R L E L K + K +L++ D L ++ + N
Sbjct: 2092 QEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTK---DEKKLARKQRKLAN 2148
Query: 761 KNKNMGQEVLNLT-KELELSKRYSRAL 786
K + M + +T +E +L++++S +
Sbjct: 2149 KMRRMINKEEKMTEEESKLARKHSEVI 2175
Score = 111 bits (277), Expect = 5e-24
Identities = 189/880 (21%), Positives = 372/880 (42%), Gaps = 119/880 (13%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIME 88
E+ ++ + + ++ KE V +RH++ + R +K K+ + + +
Sbjct: 1541 EEEVTLEEEVSREGEEKEQQVTEE---QRHIQEEHKWARIHRKRARAEKKRAQEERKLAQ 1597
Query: 89 GELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPI 148
E + ++ + + E+ ++ +A+ + ++ + + AQ++ EK
Sbjct: 1598 EEEKLAQEERQLAQEER---KLAQAYVKITQDDR--EMAQAEGKFAQKEETLAQRGEKLS 1652
Query: 149 SELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQER 208
E ++L +K+K+ LA+K + + E+ K K + N+L Q+
Sbjct: 1653 QEAEKLAQKRKK----------LAKKWEK-----VAREEEKLAKKGGKLAEVKNILAQKV 1697
Query: 209 ERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKV 268
E L + EQ +Q EKE A+ L +L ++ +E E+L + K+
Sbjct: 1698 EELPQR-EQNLDWQ---EKELAQELEELEWDM-----------EELSWKEEELNQEEGKL 1742
Query: 269 QDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHN 328
+ +KL EEEE L K E+ KL + E + + +Q E+M +
Sbjct: 1743 VEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKR 1802
Query: 329 RQLRLKLVGLTQR----IEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLR 384
QL K + L Q+ I +EE KN ++ ++K +L E E L
Sbjct: 1803 EQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEK--------KNLAQEKEKLA 1854
Query: 385 KRVLEMEGKDEEITKTESQCRELRKKL--------QEEEHHSKELRLEVEKLQKRMSELE 436
+R + E +T ++ Q +++ KL Q EE ++E ++K +K ++E E
Sbjct: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEK-LAETE 1913
Query: 437 K----LEEAFSKSKSECTQLHLNLEKEKNLT---KDLLNELEVVKSRVKELECSESRLEK 489
K +E++ +K + + Q + L EK + K L EL++ K K L RL +
Sbjct: 1914 KKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEE-KALNLEMKRLAE 1972
Query: 490 AELSL---KDDLTK-----------LKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKV 535
++ L K+ L+K + L + + ++ EKI E ++ + ++ ++
Sbjct: 1973 EKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEES-EI 2031
Query: 536 EQGKV---------MDVTEKLIEESKKLLKLKSEMEEKVYNLTR--------ERDELIGK 578
+GK+ + KL + S+KL+K + + ++ L + RDE K
Sbjct: 2032 AKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDER--K 2089
Query: 579 LKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGR-SRKGSELTCPEDN---KIKELTL 634
L EE K +++ ++ + ++RL IE+ + +I S K SELT E K ++L
Sbjct: 2090 LTQEEIKMTKMKRALFVKERRLS-IEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLAN 2148
Query: 635 EIERLKKRLQQLEVVEGDLMKTEDEY--DQLEQKFRTEQDKANFLSQQLEEIKHQIAKNK 692
++ R+ + +++ E L + E D E+ E++ FL ++ + K +K
Sbjct: 2149 KMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDK 2208
Query: 693 AIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQ 752
EK E E F E D + ++L + E +E++ + +V
Sbjct: 2209 PKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEV------ 2262
Query: 753 QRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMV--DVPVTSTGVQTDAV 810
R EEE K + G+E +E E K+ + V + V + + +T+++
Sbjct: 2263 -REEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESL 2321
Query: 811 SGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERS 850
S E EEE+ + + + E I+ +Q L++ +S
Sbjct: 2322 SDEEEEEESCS--LEEEVDREKEILKKEKQFKLQEQRRKS 2359
Score = 32.7 bits (73), Expect = 2.2
Identities = 67/319 (21%), Positives = 126/319 (39%), Gaps = 70/319 (21%)
Query: 32 LSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGEL 91
L++D KK + RK + M K T E + K S + ++ EG +
Sbjct: 2132 LTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDE-------EEGGI 2184
Query: 92 QAREDVIHMLKTEKTK------------------PEVLEAHYGSAEPEKVLRVLHRDAIL 133
+ E+VI LK K EV + S E E +L L + L
Sbjct: 2185 E-EEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESL 2243
Query: 134 A---------QEKSIGEDVYEKPISELDRLE------EKQKETYRRMLEQLLLAEKCHRR 178
+ +E+ E+V E+ + E EK++E ++ ++ E +
Sbjct: 2244 SSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKE 2303
Query: 179 TVYELENEKHKHTDYMNKSDDFTN----LLEQERERLKKLLEQEKAYQARKE-------- 226
V+E + E + + SD+ LE+E +R K++L++EK ++ +++
Sbjct: 2304 EVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGR 2363
Query: 227 -------------KENAKRLNKLRDELVKLKSFALMLVDERQMHI--EQLGLQSQK--VQ 269
K A RL L+ L KL S AL + ++ + + +Q+ + +K V
Sbjct: 2364 ERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWEDKKATVV 2423
Query: 270 DLTQKLREEEEKLKAITSK 288
++ +K +K + + K
Sbjct: 2424 EIPRKFLGTMDKEREVMGK 2442
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 122 bits (307), Expect = 2e-27
Identities = 174/822 (21%), Positives = 351/822 (42%), Gaps = 110/822 (13%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIME 88
E+ E+ + K + E+ +R L R+ K+ ++D + E
Sbjct: 185 ERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRV-FQEEEE 243
Query: 89 GELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPI 148
E + RE V+ + EK + E + E E+ LR L R +
Sbjct: 244 KEWRKRETVLRK-EEEKLQEEEPQRQRELQEEEEQLRKLERQEL---------------- 286
Query: 149 SELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQER 208
+R EE+Q++ R +QL ++ RR E E+ + + E+
Sbjct: 287 -RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE---------ERRE 336
Query: 209 ERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALM-----LVDERQMHIEQLGL 263
++L++ E+ + Q R+E+E +R +LR E + + + L E+Q+ EQ
Sbjct: 337 QQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR 396
Query: 264 QSQKVQDLTQKLREE----EEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNA 319
+ Q+++ Q RE+ E++L+ +E ++ + + + E + R +E EE
Sbjct: 397 REQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD 456
Query: 320 KLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAE 379
L +E R + + +R +E E + L+ EEE +E +++ L E
Sbjct: 457 WLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER------REQQLRRE 510
Query: 380 VENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEH----HSKELRLEVEKLQKRMS-E 434
E R++ L+ + ++E + + ++LR++ +E +E RLE E+ ++R+ E
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570
Query: 435 LEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNE----LEVVKSRVKELECSESRLEKA 490
E+ + K + E Q L E+E+ L + L E LE + R + L+ E E+
Sbjct: 571 QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERR 630
Query: 491 ELSLKDDLTKLKSFTVMLVDERKNMMEKIK--QEERKVDGLNKNFKVEQGKVMDVTEKLI 548
+ LK + + + + ++++ +++K +EE +++ K E+ + ++ E+
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 549 EESKKLLK---------LKSE---MEEKVYNLTRERDELIGKLKSEEE---KSSELSCSV 593
E++++ +K L+SE + KVY+ R+++ + + EE+ + SEL
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750
Query: 594 DLLKKRLDGIEEVEREIT----------RGRSRKGSELTCPEDNKIKELTLEIERLKKRL 643
+ R EE R+ T RGR R + P + +E L E ++R
Sbjct: 751 EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR---PPLREQRERQLRAEERQQRE 807
Query: 644 QQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFL-----------SQQLEEIKHQIAKNK 692
Q+ + E+E +Q ++ R + + FL +QQL+E + + +++
Sbjct: 808 QR-------FLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQ 860
Query: 693 AIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQ 752
E+ Q + + R++LEE + R + K + E + KE QL Q + +
Sbjct: 861 --ERRRSQEQRRDQKWRWQLEEERKR--RRHTLYAKPALQEQLRKEQQLLQEE------E 910
Query: 753 QRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRR 794
+ EE + + ++ +E +L + + LR RR
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952
Score = 111 bits (277), Expect = 5e-24
Identities = 173/891 (19%), Positives = 372/891 (41%), Gaps = 79/891 (8%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIME 88
E+ + +++++ R+E + ++R + E ++ ++ +L +E ++ +
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRRE--QQLRREQQLRREQQLRREQQLR 414
Query: 89 GELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLH--RDAILAQEKS-------- 138
E Q R + L+ E+ + + H +++ R RD + +E++
Sbjct: 415 REQQLRRE--QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472
Query: 139 ---IGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTV-YELENEKHKHTDYM 194
+ D E+ +LEE+++ + EQ L E+ RR + + E+ + +
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL 532
Query: 195 NKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVK---------LKS 245
E+ RE+L K E+++ Q R+E+ + + RD+L+K LK
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR 592
Query: 246 FALMLVDER--QMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDF 303
+++R + +E+L + ++ Q L ++ EEE + + + S+ +E+R++
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652
Query: 304 EHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELR 363
E + R +E EE + + H + R + + ++ + E + K + +L+
Sbjct: 653 ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA 712
Query: 364 D-------KIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKL----- 411
D + + G + E R+R E++ ++EE + Q E R+
Sbjct: 713 DARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQ 772
Query: 412 QEEEHHSKELRL-------EVEKLQKRMSELEKLEEAFSKSKSECTQ-LHLNLEKEKNLT 463
EE+ RL E + Q R E ++ E+ F + E Q E+EK L
Sbjct: 773 AEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL- 831
Query: 464 KDLLNELEVV--KSRVKELECSESRL-EKAELSLKDDLTKLKSFTVMLVDERKNMMEKIK 520
L E E + + R ++L+ E L E E + + + + L +ERK +
Sbjct: 832 -QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY 890
Query: 521 QEERKVDGLNKNFKVEQGKVMDVTEKL-IEESKKLLKLKSEMEEKVYNLTRERDELIGKL 579
+ L + + EQ + + E+L EE +K + + E + + ++ +E + +
Sbjct: 891 AK----PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE 946
Query: 580 KSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKI---KELTLEI 636
+ E+ + E KK E++ E R R+ E E+ ++ +E L
Sbjct: 947 EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE 1006
Query: 637 ERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAI-- 694
ER K+R Q+ E K ++ + EQ R E++K ++L+E + Q + + +
Sbjct: 1007 EREKRRRQEW---ERQYRKKDELQQEEEQLLREEREK-----RRLQERERQYREEEELQQ 1058
Query: 695 EKGEVVSQEAELRHRFRLEE--AKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQ 752
E+ +++ +E E R R LE K +L+ E + L + E ++++ Q + + + Q
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQ 1118
Query: 753 --QRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVP---VTSTGVQT 807
++ + EE + + + +E E+ + + LR RR ++ +Q
Sbjct: 1119 EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Query: 808 DAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERSSVLDRYPP 858
+ E+E + ++EE + R+ + +RS + ++ P
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEP 1229
Score = 101 bits (252), Expect = 4e-21
Identities = 174/860 (20%), Positives = 361/860 (41%), Gaps = 116/860 (13%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIME 88
E+ + + ++ R+E + +KR + E ER+ ++ +E QLL
Sbjct: 524 EEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK--- 580
Query: 89 GELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPI 148
RE+ + ++ + E LE E E++ + R+ L +E+ E+ + +
Sbjct: 581 -----REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEP--EEERRQQL 633
Query: 149 SELDRLEEKQKETYRR----MLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLL 204
+ + EE++++ RR EQ L E+ R L+ E H + + +
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE---HEEERREQELAEEEQ 690
Query: 205 EQERERLKKLL-------------EQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLV 251
EQ RER+K + Q K Y +R K+ +R + ++E + + L
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSKVY-SRPRKQEGQRRRQEQEEKRRRRESELQWQ 749
Query: 252 DERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKS-----KEDRQKLLKLEVDFEHK 306
+E + H +Q + ++ +D T + + EE+ + S +E R++ L+ E + + +
Sbjct: 750 EEERAHRQQQ--EEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE-ERQQR 806
Query: 307 ASRFSQEHEEMNAKLANQESHNRQLRL----KLVGLTQRIEELEETNKNLQK-------- 354
RF E EE + + ++L+ + + +R ++L+E LQ+
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQ 866
Query: 355 -----------AEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQ 403
EEE + R + L E + L++ E++ ++ E + + Q
Sbjct: 867 EQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ 926
Query: 404 CRELRKKLQEEEHHSKELRLEVEKLQKRMSELE-----KLEEAFSKSKSECTQLHLNLEK 458
R+ R++ Q ++ + LR E EK +++ E + KL++ + E + E+
Sbjct: 927 ERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER 986
Query: 459 EKNLTKDLLNELEVVKSRVKELECSESRLEKAELSL--KDDLTKLKSFTVMLVDERKNMM 516
EK ++ EL+ + ++ E + R ++ E KD+L + + + E++ +
Sbjct: 987 EKKYREE--EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQ 1044
Query: 517 EK---------IKQEERKVDG----------LNKNFKVEQGKVMDVTEKLIEESKKLLKL 557
E+ ++QEE ++ G L + ++ E+ + + L EE +K +
Sbjct: 1045 ERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ 1104
Query: 558 KSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRK 617
+ E + + ++ +E + + + E+ + EL ++ E++ RE R R+
Sbjct: 1105 ERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQ 1164
Query: 618 GSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLE---QKFRTEQDKA 674
E E+ +EL E E+L + Q+ E + E+E Q + Q++R E ++
Sbjct: 1165 ELERQYREE---EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221
Query: 675 NFLSQQLEEIKHQIAKNKAIEKGEVVSQ-----EAELRHR-------FRLEEAKSRDLKA 722
+ Q E ++ + NK KG Q +++LR R L E + RD +
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQ 1281
Query: 723 EVQALKEK-----IHELMNKEDQLSQLQVD-YSVLQQRFMEEENKNKNMGQEVLNLTKEL 776
E + +++ E + +E+Q + D S +++ + EE + K QE +E
Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREE 1341
Query: 777 E--LSKRYSRALRPSVNGRR 794
E L +R + LR R+
Sbjct: 1342 EQLLQEREEQPLRRQERDRK 1361
Score = 100 bits (249), Expect = 8e-21
Identities = 138/615 (22%), Positives = 276/615 (44%), Gaps = 73/615 (11%)
Query: 201 TNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQ 260
T L E++R R +E Q R+++E+ +R +RQ+ E
Sbjct: 93 TGLDEEKRARCDG---KESLLQDRRQEEDQRRFEPR----------------DRQLEEEP 133
Query: 261 LGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQK----LLKLEVDFEHKASRFSQEHEE 316
+ QK Q+ ++L E EE+ + + DRQ+ L + +++ + R ++E +
Sbjct: 134 GQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQL 193
Query: 317 MNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGE------ 370
+ K E + +L+ R E LE K ++ +++ +E +D++ + E
Sbjct: 194 QSCKGHETEEFPDEEQLR------RRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWR 247
Query: 371 CGNSSLMAEVENLR----KRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVE 426
+ L E E L+ +R E++ ++E++ K E Q ELR++ QEEE + LR E +
Sbjct: 248 KRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ--ELRRERQEEEQQQQRLRREQQ 305
Query: 427 KLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESR 486
+K+ E + +E + + Q E++ ++ E ++ + + +E + R
Sbjct: 306 LRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLR 365
Query: 487 LEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEK 546
E+ E + L + + R+ + + +Q+ R+ L + ++ + + + ++
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRR-EQQLRREQQLRREQQLRREQQLRREQQ 424
Query: 547 L-IEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEE 605
L E+ ++ + K E E + L RE++E LK EEE + K++L +E
Sbjct: 425 LRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERH---EQERRKQQLKRDQE 481
Query: 606 VEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQ 665
ER R R K E E + +E L E+ ++R Q+L K ++E ++L+Q
Sbjct: 482 EER---RERWLKLEEEERREQQERREQQLRREQEERREQRL--------KRQEEEERLQQ 530
Query: 666 KFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQ 725
+ R+EQ L ++ EE + Q+ K + E+ + + E R + EE + + LK E +
Sbjct: 531 RLRSEQQ----LRREQEERREQLLKRE--EEKRLEQERREQRLKREQEERRDQLLKREEE 584
Query: 726 ALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEV------LNLTKELELS 779
++++ +E++L Q V +R +EE + + + +E L K E
Sbjct: 585 RRQQRLKR--EQEERLEQRLKREEV--ERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640
Query: 780 KRYSRALRPSVNGRR 794
+R + LR RR
Sbjct: 641 ERRQQQLRREQQERR 655
Score = 94.4 bits (233), Expect = 6e-19
Identities = 169/798 (21%), Positives = 347/798 (43%), Gaps = 105/798 (13%)
Query: 28 GEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIM 87
GE+ + ++ ++ RKE+++ ++ L+ E R+ ++ + +E+
Sbjct: 1065 GEERETRRRQELERQYRKEEELQQEE--EQLLREEPEKRRRQERERQCREEE-------- 1114
Query: 88 EGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKP 147
ELQ E+ + + EK + + LE Y E E+V + +E+ + E+ ++
Sbjct: 1115 --ELQQEEEQLLREEREKRRRQELERQY--REEEEVQQ--------EEEQLLREEPEKRR 1162
Query: 148 ISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYEL------ENEKHKHTDYMNKSDDFT 201
EL+R + +++E ++ EQLL E+ RR E E ++ K D +
Sbjct: 1163 RQELER-QYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221
Query: 202 NLLEQERERLKKLLEQEKAYQARKEKENAKRL--NKLRDELVKLKSFALMLVDERQMHIE 259
+L Q + + K Y +E E ++L ++LRD + + +L ++++ E
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQ-QDLQHLLGEQQERDRE 1280
Query: 260 QLGLQSQK----VQDLTQKLREEEEKLKAITSKSKEDRQ--------KLLKLEVDFEHKA 307
Q + Q+ + Q REE+++ K KS+E++Q K + E D + +
Sbjct: 1281 QERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFRE 1340
Query: 308 S-RFSQEHEEM-------NAKLANQESHNRQLRLKLVGLTQRIEELEETNKNL------- 352
+ QE EE + K +E +++ K + QR+ E K L
Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400
Query: 353 -QKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKL 411
Q+ E++L++ RD+ + E ++ E RK +++++ + E + + L ++
Sbjct: 1401 CQEREQQLRQDRDRKFREE---EQQLSRQERDRK----FREEEQQVRRQERERKFLEEEQ 1453
Query: 412 QEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELE 471
Q + ++ R E + LQ+R + +E K E QL K ++L ++
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP 1513
Query: 472 VVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVD-ERKNMMEKIKQEERKVDGLN 530
K +E + + ++ L + L + + D +RK E+ ++ER+ L+
Sbjct: 1514 ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 531 KN-----FKVEQGKV--MDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEE 583
+ F++E+ KV + K +E+ ++L + + + + L +ERD K + +E
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ-----LRQERDR---KFREDE 1625
Query: 584 EKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRL 643
+ E L ++ + +E E R + +L D K +E ++ ++
Sbjct: 1626 QLLQERE--EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE-- 1681
Query: 644 QQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQE 703
QQL E D E+E Q+ R ++ + FL ++ ++++ Q + K E+ E + QE
Sbjct: 1682 QQLRRQERDRKFREEE-----QQLRRQERERKFLQEE-QQLRRQELERKFREE-EQLRQE 1734
Query: 704 AEL-------RHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQ--- 753
E R+R LEE + R + E Q +++ +E+QL Q + + + Q
Sbjct: 1735 TEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESD 1794
Query: 754 -RFMEEENKNKNMGQEVL 770
+F EEE + ++ L
Sbjct: 1795 RKFREEEQLRQEREEQQL 1812
Score = 90.1 bits (222), Expect = 1e-17
Identities = 160/792 (20%), Positives = 338/792 (42%), Gaps = 110/792 (13%)
Query: 30 KSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEG 89
+ L +++++ ++E+ ++ KR + E ER+ ++ EL +E+ L E
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPEKRRRQ---ELERQYREEEELQQEEEQLLREEQEK 1190
Query: 90 ELQAREDVIHM---LKTEKTKPEVLEAHYGSA-----EPEKVLRVLHRDAILAQEKSIGE 141
Q RE L+ +K K + S EPEK V RD + + E
Sbjct: 1191 RRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAV--RDNKVYCKGRENE 1248
Query: 142 DVYEKPISEL-DRL------------EEKQKETYRRMLEQLLLAEKCHRRTVYELENEKH 188
+ S+L DR +E+ +E RR +Q H +LE E+
Sbjct: 1249 QFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQ----RDRHFPEEEQLEREEQ 1304
Query: 189 KHTDYMN-KSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFA 247
K + KS + LL +ERE ++ E + RK +E + L + ++ ++ +
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQETD-----RKFREEEQLLQEREEQPLRRQERD 1359
Query: 248 LMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSK---EDRQKLLKLEVDFE 304
+E H EQ +K + Q+LR +E + K + + + ++R++ L+ + D +
Sbjct: 1360 RKFREEELRHQEQ----GRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK 1415
Query: 305 HKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRD 364
+ +E + K +E R+ + L + + +E ++ ++ E+ LQE +
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREE 1475
Query: 365 KIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELR-- 422
+ + + + E + LR++ + + +++E+ E + RK L+EE+ ++ R
Sbjct: 1476 QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE----RKFLEEEQQLHRQQRQR 1531
Query: 423 --LEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKEL 480
L+ E+ +R ++ + + E QL E+++ ++ + R L
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE--------RDRKFRL 1583
Query: 481 ECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEE----RKVDGLNKNFKVE 536
E + R ++ E +D +L+ R+ ++++QE R+ + L + + +
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLR---------RQEGQQQLRQERDRKFREDEQLLQEREEQ 1634
Query: 537 QGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLL 596
Q + K +EE +L + +E+ L +RD K + EE+ E
Sbjct: 1635 QLHRQERDRKFLEEEPQLRR-----QEREQQLRHDRDR---KFREEEQLLQEGEEQQLRR 1686
Query: 597 KKRLDGIEEVEREITRGR------------SRKGSELTCPEDNKIKELTLEIERLKKRLQ 644
++R E E+++ R R+ E E+ ++++ T E E+L+++ +
Sbjct: 1687 QERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQET-EQEQLRRQER 1745
Query: 645 QLEVVEGDLMKTEDEYDQL-----EQKFRTEQDKANFLSQQLEE--IKHQIAKNKAIEKG 697
+++E + ++ E E QL ++KFR E+ L Q+ EE ++ Q + K E+
Sbjct: 1746 YRKILEEEQLRPEREEQQLRRQERDRKFREEEQ----LRQEREEQQLRSQESDRKFREEE 1801
Query: 698 EVVSQEAELRHRFRLEEAKSR------DLKAEVQALKEKIHELMNKEDQLSQLQVDYSVL 751
++ + E + R + + K R L+ + Q L+++ E+Q + +
Sbjct: 1802 QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE 1861
Query: 752 QQRFMEEENKNK 763
Q+ + EEE K +
Sbjct: 1862 QELWQEEEQKRR 1873
Score = 85.1 bits (209), Expect = 4e-16
Identities = 153/751 (20%), Positives = 319/751 (42%), Gaps = 138/751 (18%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIME 88
E+ ++AK++ + +++E ++ ++ + E +RK ++ +L +E Q L E
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREEREEKRRRQ--ETDRKFREEEQLLQEREEQPLRRQE 1357
Query: 89 GELQAREDVIHMLKT------EKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGED 142
+ + RE+ + + E+ + E + E+ LR R+ L Q++
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR 1417
Query: 143 VYEKPISELDR---LEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDD 199
E+ +S +R E++++ R+ E+ L E+ R + + K + + + + +
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR---QERHRKFREEEQLLQERE 1474
Query: 200 FTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIE 259
L QER+R K LE+E+ + R+E++ R +LR + + K L +E+Q+H +
Sbjct: 1475 EQQLHRQERDR--KFLEEEQQLR-RQERDRKFREQELRSQEPERK----FLEEEQQLHRQ 1527
Query: 260 QLGLQ--------------SQKVQDLTQKLREEEEKLKAITSK--SKEDRQKLLKLEVDF 303
Q + Q+ QD +K REEE+ + + S+++R + +LE
Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLE--- 1584
Query: 304 EHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELR 363
E K R QE + M +E Q+ +++L++ R
Sbjct: 1585 EQKVRRQEQERKFME---------------------------DEQQLRRQEGQQQLRQER 1617
Query: 364 DKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRL 423
D+ + + L+ E E ++ L + +D + + E Q R ++ Q ++ R
Sbjct: 1618 DRKFRED---EQLLQERE---EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE 1671
Query: 424 EVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECS 483
E + LQ+ + + +E K + E QL + K L ++ + ++ + +E E
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 484 ESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDV 543
E+ +L ++ K +++E + E+ +Q+ R+ + ++ F+ E+
Sbjct: 1732 RQETEQEQLRRQERYRK-------ILEEEQLRPEREEQQLRRQE-RDRKFREEE------ 1777
Query: 544 TEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGI 603
+L+ E EE+ ++E D K + EE+
Sbjct: 1778 ------------QLRQEREEQQLR-SQESDR---KFREEEQLR----------------- 1804
Query: 604 EEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQL 663
+E E + R + R G + +E L++E ++RL+Q E D +E
Sbjct: 1805 QEREEQQLRPQQRDGK-------YRWEEEQLQLEEQEQRLRQ----ERDRQYRAEEQFAT 1853
Query: 664 EQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAE 723
++K R E+ + L Q+ E+ + Q + K E+ Q+ E RHR ++ E KS++ K
Sbjct: 1854 QEKSRREEQE---LWQEEEQKRRQERERKLREEHIRRQQKEEQRHR-QVGEIKSQEGKGH 1909
Query: 724 VQALKEKIHELMNKEDQLSQLQVDYSVLQQR 754
+ L+ H+ + + S L Y +Q++
Sbjct: 1910 GRLLEPGTHQFASVPVRSSPL---YEYIQEQ 1937
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 121 bits (304), Expect = 4e-27
Identities = 233/1084 (21%), Positives = 427/1084 (39%), Gaps = 173/1084 (15%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIME 88
E +L + K+ K+ +KE + ++ + + ++T K +KED+ L+S +
Sbjct: 883 ETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLR 942
Query: 89 GELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPI 148
+ D+ LKT + E +A S E L +EK + E+V +
Sbjct: 943 QTEEQVNDLKERLKTSTSNVEQYQAMVTSLEES-----------LNKEKQVTEEVRKNIE 991
Query: 149 SELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQER 208
L E Q + ++++E + EL+++K + + M EQ+
Sbjct: 992 VRLKESAEFQTQLEKKLMEV--------EKEKQELQDDKRRAIESM----------EQQL 1033
Query: 209 ERLKKLLE------QEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLG 262
LKK L QE +A N ++ + E K+ V+ + + +L
Sbjct: 1034 SELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIA------VEAQNKYERELM 1087
Query: 263 LQSQKVQDLTQKLREEEEKLKAITSKSKEDRQK----LLKLEVDFEHKASRFSQEHEEMN 318
L + V+ L Q +E+ K+ ++ +E QK LL+ + +E + E +
Sbjct: 1088 LHAADVEAL-QAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCV 1146
Query: 319 AKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMA 378
+ + E NR L +IE+L + K + +E +Q + E + +
Sbjct: 1147 CRCEDLEKQNRLLH-------DQIEKLSD--KVVASVKEGVQGPLNVSLSEEGKSQEQIL 1197
Query: 379 EVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKE--LRLEVEKLQKRMSELE 436
E+ +R E+ E+ + ES R +L E E + L E EK+Q +
Sbjct: 1198 EILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMA 1257
Query: 437 KLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKD 496
+ EE K+++ +N+ E N K L E E ++ +++++ +LE L L++
Sbjct: 1258 QHEELMKKTET------MNVVMETN--KMLREEKERLEQDLQQMQAKVRKLELDILPLQE 1309
Query: 497 DLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLK 556
+L + ML E+K + E +K+ + + L V Q K D EE +KLL
Sbjct: 1310 ANAELSEKSGMLQAEKKLLEEDVKRWKARNQHL-----VSQQKDPDT-----EEYRKLLS 1359
Query: 557 LKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSR 616
K +++ LT E IG+LK+E +S+ L + I+ ++ ++ + R+
Sbjct: 1360 EKEVHTKRIQQLTEE----IGRLKAEIARSNAS------LTNNQNLIQSLKEDLNKVRTE 1409
Query: 617 KGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANF 676
K + K+L +I ++++++ + V+ + + +Y++L + +QDK
Sbjct: 1410 K--------ETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEEL----KAQQDKVME 1457
Query: 677 LSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQ----ALKEKIH 732
S Q HQ E+ V + EL+ E KS+ L+++V+ L EK
Sbjct: 1458 TSAQSSG-DHQ-------EQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKET 1509
Query: 733 ELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLN--------------------- 771
E N ++Q QLQ + S L+Q + + + + Q++
Sbjct: 1510 EARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAG 1569
Query: 772 ----LTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDA----VSGEAAEEETPAVF 823
LTKE E K+ + AL + +DV +T+ Q + + E E + +
Sbjct: 1570 VKDQLTKENEELKQRNGALDQQ---KDELDVRITALKSQYEGRISRLERELREHQERHLE 1626
Query: 824 IRKSFQE-ENHIMSNLRQVGLKKPV---ERSSVLDRYPPAANELTMRKSWIPWMRKRENG 879
R QE N + RQ+ LK ER PP AN ++ + + +
Sbjct: 1627 QRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPTAN---IKPTPVVSTPSKVTA 1683
Query: 880 PSITQEKG-PRTNSSPGHPGEVVLSPKQGQPLHIRVTPDHENSTATLEITSPTSEEFFSS 938
++ K PR + P V +P + T E+ A F S
Sbjct: 1684 AAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGS 1743
Query: 939 TT--VIPTLGNQKPRITIIPSPNVMPQKQKSGDTTLGPERAMSP-------------VTI 983
T+ V T N +P I+ P + Q+Q + P + P V +
Sbjct: 1744 TSGSVRSTSPNVQPSIS---QPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEV 1800
Query: 984 TTFSREKTPESGRGAFADRPTSPIQIMTVST------SAAPAEIAVSPESQEMPMGRTIL 1037
S + P + F +P + T S A VS ++ EMP+ + +
Sbjct: 1801 VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLK 1860
Query: 1038 KVTP 1041
VTP
Sbjct: 1861 SVTP 1864
Score = 101 bits (252), Expect = 4e-21
Identities = 230/1165 (19%), Positives = 469/1165 (40%), Gaps = 147/1165 (12%)
Query: 66 ERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLR 125
ER K + K++ Q+++ M +L+ + L + + E L+ + +V
Sbjct: 744 ERNQKLTATTQKQE--QIINTMTQDLRGANE---KLAVAEVRAENLKKEKEMLKLSEVRL 798
Query: 126 VLHRDAILAQEKSIGEDVYEKPISELDR-LEEKQKETYRRMLEQLLLAEKCHRRTVYELE 184
R+++LA+++ G+++ + + LE + ET +R+ Q+ E +LE
Sbjct: 799 SQQRESLLAEQR--GQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLE 856
Query: 185 NE-KHKHT----------DYMNKSDDFTNLLEQERERLKKL-------------LEQEKA 220
NE + +HT D + D TNL +E LK +E + A
Sbjct: 857 NEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVA 916
Query: 221 YQARKEKENAKRLNKLR-DELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEE 279
Q+ + + NK D+LV V++ + ++ ++ Q + L E
Sbjct: 917 SQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL 976
Query: 280 EKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLT 339
K K +T + +++ + LK +F+ + + E E+ +L + + R + +
Sbjct: 977 NKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDK------RRAIESME 1030
Query: 340 QRIEELEETNKNLQ-KAEEELQEL-----RDKIAKGECGNSSLMA-EVENLRKRVLEMEG 392
Q++ EL++T ++Q + +E LQ ++ A+ +C + +A E +N +R L +
Sbjct: 1031 QQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHA 1090
Query: 393 KDEEITKTESQCRELRKKLQEEEHHSKELRLEVE-KLQKRMSELEKLEEAFSKSKSECTQ 451
D E + +E K+ H +E + E +L + + E+ E S+C
Sbjct: 1091 ADVEALQA---AKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVC 1147
Query: 452 LHLNLEKEKNLTKDLLNEL-EVVKSRVKE-----LECSESRLEKAELSLKDDLTKLKS-- 503
+LEK+ L D + +L + V + VKE L S S K++ + + L ++
Sbjct: 1148 RCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREK 1207
Query: 504 ------FTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKL 557
F V V+ + ++++ ER++ L + E+ KV VT K + + ++L+K
Sbjct: 1208 EIAETRFEVAQVESLR-YRQRVELLERELQELQDSLNAEREKVQ-VTAKTMAQHEELMKK 1265
Query: 558 KSEMEEKVYNLTRERDELIGKLKSE-EEKSSELSCSVDLLKKRLDGIEEVEREITRGRSR 616
M N+ E ++++ + K E+ ++ V L+ + ++E E+ S
Sbjct: 1266 TETM-----NVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAEL----SE 1316
Query: 617 KGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANF 676
K L + K L +++R K R Q L + D +EY +L + +
Sbjct: 1317 KSGMLQAEK----KLLEEDVKRWKARNQHLVSQQKD--PDTEEYRKLLSEKEVHTKRIQQ 1370
Query: 677 LSQQLEEIKHQIAKNKA--IEKGEVVSQEAELRHRFRLE-EAKSRDLKAEVQALKEKIHE 733
L++++ +K +IA++ A ++ E ++ R E E +DL A++ ++EK+
Sbjct: 1371 LTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKT 1430
Query: 734 LMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGR 793
+ Q+ ++ Y + +++K + +E +S + + L+ ++N
Sbjct: 1431 IT----QVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLN-- 1484
Query: 794 RMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERSSVL 853
+ S Q + + +E+ET A +++ + +S LRQ + + +
Sbjct: 1485 -QAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQL- 1542
Query: 854 DRYPPAANELTMRKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEVVLSPKQGQPLHIR 913
R E RK+ + K + + + G + +Q L +R
Sbjct: 1543 -RQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGAL---DQQKDELDVR 1598
Query: 914 VTP---DHENSTATLEITSPTSEEFFSSTTVIPTLGNQKPRITIIPSPNVMPQKQKSGDT 970
+T +E + LE +E P Q+P N +P++Q+
Sbjct: 1599 ITALKSQYEGRISRLERELREHQERHLEQRDEP----QEPS-------NKVPEQQRQ--- 1644
Query: 971 TLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAEIAVSPESQEM 1030
IT + + E G + +D PT+ I+ V ++ + A ++
Sbjct: 1645 ------------ITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKST 1692
Query: 1031 PMGRTILKVTPEKQTVPT--------PVRKYNSNANIITTEDNKIHIHLGSQFKRSPGTS 1082
P VTP T PT P + S + +E H+ + S ++
Sbjct: 1693 PRASIRPMVTPATVTNPTTTPTATVMPTTQVESQ-EAMQSEGPVEHVPVFGSTSGSVRST 1751
Query: 1083 GEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITIT--------PV 1134
V P I+ +P+ ++ +T V + ++H P +++S I P
Sbjct: 1752 SPNVQPSIS-QPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQSSPVERPS 1810
Query: 1135 TTSSARGTQSVSGQDGSSQRPTPTR 1159
T+++ GT S + SS P TR
Sbjct: 1811 TSTAVFGTVSAT---PSSSLPKRTR 1832
Score = 91.3 bits (225), Expect = 5e-18
Identities = 179/818 (21%), Positives = 351/818 (42%), Gaps = 95/818 (11%)
Query: 68 KTKKSLELSKEDLIQLLSIMEGELQ-AREDVIHM---LKTEKTKPEVLEAHYGSAEPEKV 123
+TK+ LE K DLI+ + EL+ EDV + LK T L+ + V
Sbjct: 115 RTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDV 174
Query: 124 LRVLHRDAILAQEKSIGEDVYEKPISEL----DRLEEKQKETYRRMLEQLLLAEKCHRRT 179
V +R+ L QEK + +EL D L +E +LE KC+
Sbjct: 175 -SVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILEL-----KCN--- 225
Query: 180 VYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDE 239
LEN+K + +++ ++ N L+ E L+K +E +++ A K +E
Sbjct: 226 ---LENKKEE----VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNE 278
Query: 240 L---VKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKL 296
L +KL + D+ + +L ++ V++L + L+E E KAI E Q
Sbjct: 279 LNAHIKLSNLYKSAADDSEAKSNEL---TRAVEELHKLLKEAGEANKAIQDHLLEVEQSK 335
Query: 297 LKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKN----- 351
++E + K R +E E N L+ K G EEL +
Sbjct: 336 DQMEKEMLEKIGRLEKELENANDLLS---------ATKRKGAILSEEELAAMSPTAAAVA 386
Query: 352 -LQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKK 410
+ K +L EL + A E + L+ ++EN KR+ + DE + + E++ L+++
Sbjct: 387 KIVKPGMKLTELYN--AYVETQDQLLLEKLEN--KRINKY--LDEIVKEVEAKAPILKRQ 440
Query: 411 LQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNEL 470
+E E K + KL++ M E+++L+E K+ + + L + + + KDL ++
Sbjct: 441 REEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI 500
Query: 471 EVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLN 530
V+ ++E + E+S D + + + LV R N+ E +Q +R + L
Sbjct: 501 RVLLMELEEAR-GNHVIRDEEVSSADISSSSEVISQHLVSYR-NIEELQQQNQRLLVALR 558
Query: 531 KNFKVEQGKVMDVTEKLIEESKKLLKLKSEME--EKVYNLTRERDELIGKLKSEEEK--- 585
+ + + + + T I E + LKL+S + E++ + + +L+ + + +
Sbjct: 559 ELGETREREEQETTSSKITELQ--LKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRI 616
Query: 586 --SSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRL 643
S ++ L LD +V T R ++ P + E T IE K L
Sbjct: 617 LLSQTTGVAIPLHASSLD---DVSLASTPKRPSTSQTVSTPAPVPVIESTEAIE-AKAAL 672
Query: 644 QQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQE 703
+QL+ + + K + E ++++ ++QLE+++ Q+ ++ + ++ +Q
Sbjct: 673 KQLQEIFENYKKEKAENEKIQ-------------NEQLEKLQEQVTDLRS-QNTKISTQL 718
Query: 704 AELRHRFRLEEAKSRDLKAEVQALKEKIHEL----MNKEDQLSQLQVDYSVLQQRFMEEE 759
R+ + + + E+ +L E+ +L +E ++ + D ++ E
Sbjct: 719 DFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE 778
Query: 760 NKNKNM--GQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEE 817
+ +N+ +E+L L+ E+ LS++ +L G+ ++ T +QT E +E
Sbjct: 779 VRAENLKKEKEMLKLS-EVRLSQQ-RESLLAEQRGQNLL-----LTNLQTIQGILERSET 831
Query: 818 ETPAVFIRKSFQEENHIMSNLRQVGLKKPVERSSVLDR 855
ET + ++ H +S+L++ L+ VE+ L R
Sbjct: 832 ETKQ-RLSSQIEKLEHEISHLKK-KLENEVEQRHTLTR 867
Score = 88.6 bits (218), Expect = 3e-17
Identities = 149/708 (21%), Positives = 289/708 (40%), Gaps = 81/708 (11%)
Query: 195 NKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDER 254
NK + F + E + LK E+ K ++ E KRL+ ++ LV L
Sbjct: 23 NKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSL---- 78
Query: 255 QMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEH 314
++ +E+L Q + + + ++L +++ AI S+ +++L + D R SQE
Sbjct: 79 RLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQEL 138
Query: 315 E-------EMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIA 367
E +N KL + +L+LKL +EL+ ++ +++ E+ L++ ++ +
Sbjct: 139 EYLTEDVKRLNEKLKESNTTKGELQLKL-------DELQASDVSVKYREKRLEQEKELL- 190
Query: 368 KGECGNSSLMAEVENLRKRVLEM-EGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVE 426
N+ L E++ +L + K EI + + ++++ E L+ E
Sbjct: 191 --HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNE 248
Query: 427 KLQKRMSE-LEKLEEAFSKSKSECTQLHLNLE---KEKNLTKDLLNELEVVKSR----VK 478
LQK + + L KL+EA + S + H L K NL K ++ E + V+
Sbjct: 249 HLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVE 308
Query: 479 ELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQG 538
EL +A +++D L +++ + K M+EKI + E++++ N +
Sbjct: 309 ELHKLLKEAGEANKAIQDHLLEVEQSKDQM---EKEMLEKIGRLEKELENANDLLSATKR 365
Query: 539 KVMDVTE--------------KLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEE 584
K ++E K+++ KL +L + E L E+ E K +E
Sbjct: 366 KGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDE 425
Query: 585 KSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQ 644
E+ +LK++ + E ++ + + L+ + +KE+ E K +
Sbjct: 426 IVKEVEAKAPILKRQREEYERAQKAV--------ASLSVKLEQAMKEIQRLQEDTDKANK 477
Query: 645 QLEVVEGDLMKTEDEYDQLEQKFRT-----EQDKANFLSQQLEEIKHQIAKNKAIEKGEV 699
Q V+E D + E + L Q+ R E+ + N + + E I+ + + +
Sbjct: 478 QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHL 537
Query: 700 VS-------QEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNK------------EDQ 740
VS Q+ R L E + E + KI EL K + +
Sbjct: 538 VSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSR 597
Query: 741 LSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPV 800
Q+Q+ S+++QR M ++ G + L+ S RPS + PV
Sbjct: 598 QHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPV 657
Query: 801 TSTGVQTDAVSGEAAEEETPAVFIR-KSFQEENHIMSNLRQVGLKKPV 847
T+A+ +AA ++ +F K + EN + N + L++ V
Sbjct: 658 PVI-ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
Score = 87.4 bits (215), Expect = 7e-17
Identities = 121/587 (20%), Positives = 260/587 (44%), Gaps = 82/587 (13%)
Query: 26 NAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSG--------EC-----ERKTKKS 72
N E+ L A + ++ V +V++HL+ + EC ER+
Sbjct: 1080 NKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLK 1139
Query: 73 LELSK-----EDLIQLLSIMEGELQARED-VIHMLKTEKTKPEVLEAHYGSAEPEKVLRV 126
E+SK EDL + ++ +++ D V+ +K P + E++L +
Sbjct: 1140 DEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI 1199
Query: 127 LHRDAILAQEKSIGEDVYEKPISELDRLEEKQK-ETYRRMLEQLLLAEKCHRRTVYELEN 185
L + +EK I E +E +++++ L +Q+ E R L++L + R V
Sbjct: 1200 LR---FIRREKEIAETRFE--VAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAK 1254
Query: 186 EKHKHTDYMNKSD------DFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDE 239
+H + M K++ + +L +E+ERL++ L+Q +A + E + + L++
Sbjct: 1255 TMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELD----ILPLQEA 1310
Query: 240 LVKLKSFALMLVDERQMHIEQLGLQSQKVQDLT--QKLREEEEKLKAITSKSKEDR--QK 295
+L + ML E+++ E + + Q L QK + EE K ++ K + Q+
Sbjct: 1311 NAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQ 1370
Query: 296 L------LKLEVDFEHKASRFSQE-----HEEMNAKLANQESHNRQLRLKLVGLTQRIEE 344
L LK E+ + + +Q E++N +E+ + L K++ + ++++
Sbjct: 1371 LTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKT 1430
Query: 345 LEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQC 404
+ + K ++ + + +EL+ A+ + + + + G +E + +
Sbjct: 1431 ITQVKKIGRRYKTQYEELK--------------AQQDKVMETSAQSSGDHQEQHVSVQEM 1476
Query: 405 RELRKKLQEEEHHSKELRLEVEKLQKRMSELE----KLEEAFSKSKSECTQLHLNLEKEK 460
+EL++ L + E SK L +VE LQK +SE E L+E + +SE ++L +L+
Sbjct: 1477 QELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQ--- 1533
Query: 461 NLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEK-- 518
D + E ++ ++ E E + KA ++ K + L L E + + ++
Sbjct: 1534 ----DRTTQEEQLRQQITE---KEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNG 1586
Query: 519 -IKQEERKVDGLNKNFKVE-QGKVMDVTEKLIEESKKLLKLKSEMEE 563
+ Q++ ++D K + +G++ + +L E ++ L+ + E +E
Sbjct: 1587 ALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 121 bits (303), Expect = 5e-27
Identities = 187/853 (21%), Positives = 359/853 (42%), Gaps = 161/853 (18%)
Query: 59 LKTSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSA 118
L+ + ++ ++LE K L+ +S +GEL+ ML+ E TK +L
Sbjct: 1852 LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELK-------MLQEEVTKMNLLNQQI--- 1901
Query: 119 EPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEK-----QKETYRRMLEQLLLAE 173
E++ RV +EK +D+ E+ +++L L Q T ++ +LL +E
Sbjct: 1902 -QEELSRVTKLKETAEEEK---DDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957
Query: 174 -KCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKR 232
K ++ V ELE EK + K + E +E L+K+ +K + + +
Sbjct: 1958 MKNLKKCVSELEEEKQQLVKEKTKVES-----EIRKEYLEKIQGAQKEPGNKSHAKELQE 2012
Query: 233 LNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQK-LREEEEKLKAITSKSKE 291
L K + + VK + E+ +E+ + VQ +QK L +E L K+
Sbjct: 2013 LLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKK 2072
Query: 292 DRQKLLKLEV---DFEHKASRFSQEHEEMNAKL-ANQESHNRQLRLKLVGLTQRIEELEE 347
+ +L +V D + +A+R ++ ++ +L +N+ES Q++ K L +R+E+ EE
Sbjct: 2073 AQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEE 2132
Query: 348 TN----KNLQ----------------------------KAEEELQELRDKIAKGECGNSS 375
+ KN+Q K ++LQE D +
Sbjct: 2133 KHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTK 2192
Query: 376 LMAEVENLRKRVLE------------MEGKDEEITKTESQCRELRKKLQEEEHHSKELRL 423
M+ +++ R RV++ ++ K+EEI E C L+ +L++ H +EL++
Sbjct: 2193 SMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKI 2252
Query: 424 EVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECS 483
+ +L+ E SK+++E + + K+LL++LE + +
Sbjct: 2253 NISRLEHDKQIWE------SKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNE 2306
Query: 484 ESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKV--- 540
++LE SLKD LT L + +++ N+ I+Q+E + N F EQ +
Sbjct: 2307 LAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQ--NSKFSYEQLETDLQ 2364
Query: 541 --MDVTEKLIEE----SKKLLKLKSEMEEKVY----NLTRERD----ELIGKLKSEEEKS 586
++T +L EE +K++ L S EE + L ++ D EL L EEE++
Sbjct: 2365 ASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEEN 2424
Query: 587 ----SELSCSVDLLKKRLDGIEEVEREITRGRSRKGS----------------------- 619
E +VD + ++ ++ +++E + +++ S
Sbjct: 2425 IVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLE 2484
Query: 620 ----ELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKAN 675
+ +D I+E E +LK+ ++ L DL + D ++R + ++
Sbjct: 2485 ERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVI 2544
Query: 676 FL--SQQLEEIKHQIAKNKAIE----KGEVVSQEAE-----LRHRFRLEEAKSRDLKAEV 724
+ SQQ + ++ Q+ +NK +E K E +E+E LR F + + +DL E+
Sbjct: 2545 TIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEI 2604
Query: 725 QALKEKIHELMN--------------------KEDQLSQLQVDYSVLQQRFMEEENKNKN 764
++LK I +L KE+++ +L +S Q+R E E +
Sbjct: 2605 ESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVC 2664
Query: 765 MGQEVLNLTKELE 777
+ +E E+E
Sbjct: 2665 VQKEAAKKVGEIE 2677
Score = 112 bits (281), Expect = 2e-24
Identities = 164/830 (19%), Positives = 361/830 (43%), Gaps = 136/830 (16%)
Query: 39 KKKSNRKEDDVMASGTVKRHLKTSGECERK----TKKSLEL-SKEDLIQLLSIMEGELQA 93
+K ++KE+DV SG+ K TK E+ +EDLI+ L + E+QA
Sbjct: 1398 QKLISKKEEDVSY---------LSGQLSEKEAALTKIQTEIIEQEDLIKALHT-QLEMQA 1447
Query: 94 RE--DVIHMLKTE----KTKPEVL-EAHYGSAEPEKVLR--VLHRDAILAQEKSIGEDV- 143
+E + I L+ E K KPE + E + ++ L+ ++ R L + KS+ E++
Sbjct: 1448 KEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELS 1507
Query: 144 --------YEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMN 195
K +++++ Q + +L +L L ++ + + E++ ++ +
Sbjct: 1508 LARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSS 1567
Query: 196 KSDDFTNLLE---QERERLKKLLEQEKAYQARKEKENAKRLNKLRDEL-VKLKSFALMLV 251
+ LE +++E+L K +E K+ + + E ++ +L+ E + L+S+
Sbjct: 1568 SCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSY----- 1622
Query: 252 DERQMHIEQLGLQSQKVQDLTQKLREEEE----KLKAITSKSKEDRQKLLKLEVDFEHKA 307
E + +++++Q + + +R+E++ KL++ + KE ++L + E + E
Sbjct: 1623 -------ENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMK 1675
Query: 308 SRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEET--------NKNLQKAEEEL 359
+ + + K+ E N +LR ++ +E ET + L++ + E
Sbjct: 1676 EKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEY 1735
Query: 360 QELRDKIAKGECGNSSLMAEVENLRKRV---------LEMEGK-DEEITKTESQCRELRK 409
+ L K SL EV++L+ ++ LE K D + TE + +
Sbjct: 1736 ETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPG 1795
Query: 410 KLQEEEHHSKELRL------------------------EVEKLQKRMSELEKLEEAFSKS 445
+ +E++ S R E+ +++ +L++ +
Sbjct: 1796 ETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEE 1855
Query: 446 KSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFT 505
K + + LE EKN LL+++ +K L+ +++ ++++L+++
Sbjct: 1856 KQKNKEFSQTLENEKNT---LLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLK 1912
Query: 506 VMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKV 565
+E+ ++ E++ + +++G N+ + E L E K L K SE+EE+
Sbjct: 1913 ETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEK 1972
Query: 566 YNLTRE--------RDELIGKLKSEEEKSSELSCS---VDLLKKRLDGIEEVEREITR-- 612
L +E R E + K++ +++ S + +LLK++ +++++++ R
Sbjct: 1973 QQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ 2032
Query: 613 ------GRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQK 666
R+ K E E K E+T E L + ++ + + +L + D
Sbjct: 2033 EKISALERTVKALEFVQTESQKDLEITK--ENLAQAVEHRKKAQAELASFKVLLDD---- 2086
Query: 667 FRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQA 726
T+ + A L+ L ++K ++ NK K ++ ++ +L RLE+A+ + LK E +
Sbjct: 2087 --TQSEAARVLADNL-KLKKELQSNKESVKSQMKQKDEDLER--RLEQAEEKHLK-EKKN 2140
Query: 727 LKEKI----HELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNL 772
++EK+ E ++ E+ + ++QV L ++ E + +N+ V L
Sbjct: 2141 MQEKLDALRREKVHLEETIGEIQV---TLNKKDKEVQQLQENLDSTVTQL 2187
Score = 101 bits (251), Expect = 5e-21
Identities = 165/786 (20%), Positives = 345/786 (43%), Gaps = 107/786 (13%)
Query: 70 KKSLELSKEDLIQLLSIME-GELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEK------ 122
K+ +EL E LLS +E EL+A + + T +LEA + E ++
Sbjct: 475 KRVVELENEKGALLLSSIELEELKAENEKLSSQIT------LLEAQNRTGEADREVSEIS 528
Query: 123 VLRVLHRDAILAQEKSIGEDVYEKPISELDR------LEEKQKETYRRMLEQLLLAEKCH 176
++ + ++ + A+E G+DV E S+ + LE K+ + L+ L ++
Sbjct: 529 IVDIANKRSSSAEES--GQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAE 586
Query: 177 RRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKL 236
L+ ++ K + + + ++ + L+ E++ EKE A ++
Sbjct: 587 EADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQS 646
Query: 237 R-DELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQK 295
R E + L + L +Q + L V D+ Q ++E E+LK+ + + + K
Sbjct: 647 RTSEEISLNDAGVELKSTKQDGDKSLSA----VPDIGQCHQDELERLKSQILELELNFHK 702
Query: 296 LLKL-EVDFEHKA---SRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEEL------ 345
++ E + + KA S +Q EE N S L + L +++EL
Sbjct: 703 AQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTEL 762
Query: 346 ----EETNKNLQKAEE------ELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDE 395
++ NL +AE E Q D + + + S+ A+ ++++ VL+ E D
Sbjct: 763 RAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDV 822
Query: 396 EITKTESQC--RELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLH 453
++ +E R L+ +LQ +E E+ E+++ S++E+L +A S+ + E T++
Sbjct: 823 QLQFSEQSTLIRSLQSQLQNKE---SEVLEGAERVRHISSKVEELSQALSQKELEITKMD 879
Query: 454 LNLEKEKNLTKDLLNELEVVKSRVKELECSES----RLEKAELSLKDDLTKLKSFTVMLV 509
L ++K + L +E +V E+ S + +L + + SL ++ LK +L
Sbjct: 880 QLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLS 939
Query: 510 DERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEE-KVYNL 568
+ E+++++ GL +N+ E ++++ ++ LLK ++E + K+
Sbjct: 940 RAEEAKKEQVEEDNEVSSGLKQNYD-EMSPAGQISKEELQHEFDLLKKENEQRKRKLQAA 998
Query: 569 TRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNK 628
R EL+ ++ EE+ + L D KK + E E+ + K C +K
Sbjct: 999 LINRKELLQRVSRLEEELANLK---DESKKEIPLSETERGEVEEDKENKEYSEKCVT-SK 1054
Query: 629 IKELTLEIER-LKKRLQQLEVVEGDL---MKTEDEYDQL-EQKFRTEQDKANFLSQQLEE 683
+E+ + +++ + ++ +L+ + DL + E+++ L +Q +T QDK N Q++
Sbjct: 1055 CQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTN----QIDL 1110
Query: 684 IKHQIAKNKAIEKGEVVSQ-----------------------------EAELRHRFRLEE 714
++ +I++N+AI + + S + EL + E
Sbjct: 1111 LQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALE 1170
Query: 715 AKSRDLKAEVQA--------LKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMG 766
+ L+ ++Q LK+ + + ++L Q + DY+ LQ++F E+ +N+N+G
Sbjct: 1171 KEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIG 1230
Query: 767 QEVLNL 772
++ L
Sbjct: 1231 DQLRQL 1236
Score = 97.4 bits (241), Expect = 7e-20
Identities = 171/775 (22%), Positives = 320/775 (41%), Gaps = 103/775 (13%)
Query: 66 ERKTKKSLELSKEDLIQL----LSIMEGELQAREDVIHM--LKTEKTKPEVLEAHYGS-A 118
ERK +++ SKE+ I+L S+++ +L R+ IHM LK ++ E + + S A
Sbjct: 2212 ERKFSDAIQ-SKEEEIRLKEDNCSVLKDQL--RQMSIHMEELKINISRLEHDKQIWESKA 2268
Query: 119 EPEKVLRVLHRDAILAQEKSI------GEDVYEKPISELDRLEEKQKETYRRMLEQLLLA 172
+ E L+ D + + K + +Y +EL +LE + K ++ +
Sbjct: 2269 QTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSL 2328
Query: 173 EKCHRRTVYELENEKHKHTDYMNKSDDFTNL---LEQERERLKKL-----LEQEKAYQAR 224
EKC + + + D N + L L+ RE +L ++++K
Sbjct: 2329 EKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLL 2388
Query: 225 KEKENA-----KRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEE 279
KE A L + D+ +K L +E + +E+ +++K D T +L E
Sbjct: 2389 SGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEE---ENKKAVDKTNQLMETL 2445
Query: 280 EKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLT 339
+ +K + K +K ++ R +++++ +E H L +
Sbjct: 2446 KTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL------EERH-------LSIIL 2492
Query: 340 QRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITK 399
++ + ++E K +EE++ LR + N+ L AE+ R E ++ IT
Sbjct: 2493 EKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYR------EDLNQVITI 2546
Query: 400 TESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKE 459
+SQ ++L L+ + +KEL + KL++++ E E+ E +S + + +L KE
Sbjct: 2547 KDSQQKQL---LEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKE 2603
Query: 460 KNLTKDLLNELEVVKSRVKE----------LECSESRLEKAELSLKDDLTKLKSFTVMLV 509
K +++L + ++E L+ E + + ++ LV
Sbjct: 2604 IESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELV 2663
Query: 510 DERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLT 569
+K +K+ + E K+ K+ + G + + TE E +L + EME+K+ +T
Sbjct: 2664 CVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVT 2723
Query: 570 RERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKI 629
+E L +++S S L S D + LD EL D +
Sbjct: 2724 KENKGLTAQIQSFGRSMSSLQNSRDHANEELD------------------ELKRKYDASL 2765
Query: 630 KELTLEIER---LKKRLQQLEVVEGDLMKTED----EYDQLEQKFRTEQDKANFLSQQLE 682
KEL E+ ++R L + TE+ ++L Q+ ++ ++ LS QLE
Sbjct: 2766 KELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLE 2825
Query: 683 EIKHQI---AKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL------KAEVQALKEKIHE 733
+ +Q+ +K A + E EL + EE K R AEVQ+LK+ +
Sbjct: 2826 DSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSS 2885
Query: 734 LMNKED----QLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSR 784
L N D +L LQ Y + Q + E + K QE + TK ++ + R
Sbjct: 2886 LQNDRDRLLKELKNLQQQYLQINQE-ITELHPLKAQLQEYQDKTKAFQIMQEELR 2939
Score = 94.0 bits (232), Expect = 8e-19
Identities = 161/778 (20%), Positives = 328/778 (42%), Gaps = 66/778 (8%)
Query: 37 KKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQARED 96
K+K++ +K + + S K LK + E ER ++ L+ K+D +L + + + E+
Sbjct: 1171 KEKEQLQKKLQEALTSR--KAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENEN 1228
Query: 97 VIHMLKTEKTKP-EVLEAHYGSAEPEKVLRV---LHRDAILAQEKSIGEDVYEKPI---- 148
+ L+ + + E ++ S + ++ L A E+ + V E +
Sbjct: 1229 IGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDW 1288
Query: 149 -SELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQE 207
S + Q T ++ L + + ELE + T + K + L+++
Sbjct: 1289 PSHSEDASALQGGTSVAQIKAQLKEIEAEK---VELELKVSSTTSELTKKSEEVFQLQEQ 1345
Query: 208 RERLKKLLEQEKAYQARKEKE-NAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQ 266
K+ LE E E E +A+ L + KL+S L + +E L
Sbjct: 1346 IN--KQGLEIESLKTVSHEAEVHAESLQQ------KLESSQLQIAG-----LEHLRELQP 1392
Query: 267 KVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQES 326
K+ +L + + ++EE + ++ + E L K++ + + H ++ + +
Sbjct: 1393 KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE 1452
Query: 327 HNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKR 386
+QL+++L + Q+ EE+ E ++ Q+ + +LQ + N SL E+ R
Sbjct: 1453 RIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGT 1512
Query: 387 VLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSK 446
+ E + + ESQ K E++ L L E+ K ++E+++
Sbjct: 1513 I---ERLTKSLADVESQVSAQNK---EKDTVLGRLALLQEERDKLITEMDRSLLENQSLS 1566
Query: 447 SECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTV 506
S C L L LE + L+ E+E +KS K E +E + + EL + ++ V
Sbjct: 1567 SSCESLKLALEGLTEDKEKLVKEIESLKSS-KIAESTEWQEKHKELQKEYEILLQSYENV 1625
Query: 507 MLVDER-KNMMEKIKQEERKVDG----LNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEM 561
ER ++++E ++QE++++ G N K + ++ + +++ E +K+ K
Sbjct: 1626 SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSK 1685
Query: 562 EEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGR--SRKGS 619
++K+ L E D L ++ + + E C LL EE+ER S+K
Sbjct: 1686 QQKILELEEENDRLRAEVHPAGDTAKE--CMETLLSSNASMKEELERVKMEYETLSKKFQ 1743
Query: 620 ELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLE------QKFRTEQDK 673
L +D+ L+ E++ LK +++ + +L TE +Q Q E ++
Sbjct: 1744 SLMSEKDS----LSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEE 1799
Query: 674 ANFLSQQL-----EEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSR--DLKAEVQA 726
+ LS E + + N A+ K + S + + ++++ K R L+ E Q
Sbjct: 1800 QDSLSMSTRPTCSESVPSAKSANPAVSK-DFSSHDEINNYLQQIDQLKERIAGLEEEKQK 1858
Query: 727 LKEKIHELMNKED----QLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSK 780
KE L N+++ Q+S + +LQ+ + N+ + +E+ +TK E ++
Sbjct: 1859 NKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAE 1916
Score = 86.7 bits (213), Expect = 1e-16
Identities = 179/864 (20%), Positives = 351/864 (40%), Gaps = 124/864 (14%)
Query: 64 ECERKTKKSLELSKEDLIQLLSI--MEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPE 121
E + + + + L +++L+QL++ +E E+Q + V+ E + V A +
Sbjct: 221 EKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQ 280
Query: 122 KVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVY 181
++ R+ IL+Q+ E + + L E ++E + +LE++ L + + +
Sbjct: 281 ELTAAEQRNQILSQQLQQMEAEH----NTLRNTVETEREESKILLEKMELEVAERKLSFH 336
Query: 182 ELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELV 241
L+ E H +LLEQ + + E E Y A ++K A+
Sbjct: 337 NLQEEMH-------------HLLEQFEQAGQAQAELESRYSALEQKHKAE---------- 373
Query: 242 KLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEK-LKAITSKSKEDRQKLLKLE 300
++E+ HI L Q++Q L+++ K L+ ++ + Q + +LE
Sbjct: 374 ---------MEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLE 424
Query: 301 VDFEHKASRFSQ-------EHEEMNAKLANQESHNRQLRL----KLVGLTQRIEELEETN 349
+ K+ SQ + E ++ + + +N + + L +R+ ELE
Sbjct: 425 DQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEK 484
Query: 350 KNLQKAEEELQELRDKIAK--------------GECG---NSSLMAEVENLRKRVLEMEG 392
L + EL+EL+ + K GE + + ++ N R E G
Sbjct: 485 GALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESG 544
Query: 393 KDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQL 452
+D + +EL L E + +E+ +LQ + +E E K +
Sbjct: 545 QDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGE 604
Query: 453 HLNLEKEKNLTKD-------LLNELEVVKSRVKELECSESRLEKA-ELSLKDDLTKLKSF 504
+ K K +D + NE + + KE +E + + E+SL D +LKS
Sbjct: 605 GIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKS- 663
Query: 505 TVMLVDERKNMMEKIKQ----EERKVDGLNKNFKVEQGKVMDVTEK-LIEESKKLLKLKS 559
T D+ + + I Q E ++ ++ K ++ EK L E++K++ L
Sbjct: 664 TKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQ 723
Query: 560 EMEEKVYN----------LTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVERE 609
+EE N L+ ERD+L+ ++K E +EL V L+ L E R
Sbjct: 724 LIEEFKKNADNNSSAFTALSEERDQLLSQVK-ELSMVTELRAQVKQLEMNLAEAERQRRL 782
Query: 610 ITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRT 669
++ + LT +I L++E + +++ L+ D+ E L + ++
Sbjct: 783 DYESQTAHDNLLT----EQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQS 838
Query: 670 E-QDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQ-EAELRHRFRLEEAKSRDLKAEVQAL 727
+ Q+K + + + E ++H +K E + +SQ E E+ +L K RD++ Q +
Sbjct: 839 QLQNKESEVLEGAERVRH--ISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTI 896
Query: 728 KEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALR 787
+EK ++ ++ +S+ ++ E K ++G E+ L ++L L R A +
Sbjct: 897 EEKDQQV---------TEISFSMTEKMVQLNEEK-FSLGVEIKTLKEQLNLLSRAEEAKK 946
Query: 788 PSVNGRRMVDVPVTSTGVQTD----AVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGL 843
V V S+G++ + + +G+ ++EE F ++EN Q L
Sbjct: 947 EQVEEDNEV-----SSGLKQNYDEMSPAGQISKEELQHEF--DLLKKENEQRKRKLQAAL 999
Query: 844 KKPVERSSVLDRYPPAANELTMRK 867
+ R +L R EL K
Sbjct: 1000 ---INRKELLQRVSRLEEELANLK 1020
Score = 81.6 bits (200), Expect = 4e-15
Identities = 167/821 (20%), Positives = 349/821 (42%), Gaps = 120/821 (14%)
Query: 5 NQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASG-TVKRHLKTSG 63
N+G ++ ++ +I+ + ++ EK + + + + E++ ++S T+ +G
Sbjct: 459 NEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTG 518
Query: 64 ECER------------KTKKSLELSKEDLIQL--------LSIMEGELQAREDVIHMLKT 103
E +R K S E S +D+++ LS++ E++ ++ I LK
Sbjct: 519 EADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKL 578
Query: 104 EKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSI-----GEDVYEKPISE--LDRLEE 156
+ EA + + +K ++ + + I + + G+D P E L +E+
Sbjct: 579 QLQGKRAEEADHEVLD-QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEK 637
Query: 157 KQKETYR--RMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLK-K 213
+Q T R E++ L + EL++ K ++ D + E ERLK +
Sbjct: 638 EQASTEHQSRTSEEISLND-----AGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQ 692
Query: 214 LLEQEKAYQARKE------KENAKRLNKLRDELVKLKSFA-------------------- 247
+LE E + +E E AK ++ L + + K A
Sbjct: 693 ILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQ 752
Query: 248 ---LMLVDERQMHIEQLGL-----QSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKL 299
L +V E + ++QL + + Q+ D + + + I S S E + K +K+
Sbjct: 753 VKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKI 812
Query: 300 EV------DFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQ 353
EV D + + S S + ++L N+ES + ++ ++ ++EEL + L
Sbjct: 813 EVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQA---LS 869
Query: 354 KAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQE 413
+ E E+ ++ + + + +VE L++ + E KD+++T+ E +L E
Sbjct: 870 QKELEITKMDQLLLEKK-------RDVETLQQTI---EEKDQQVTEISFSMTEKMVQLNE 919
Query: 414 EEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKN--------LTKD 465
E+ L +E++ L+++++ L + EEA + E ++ L++ + ++
Sbjct: 920 EKF---SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEE 976
Query: 466 LLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERK 525
L +E +++K KE E + +L+ A ++ K+ L ++ L + + ++I E +
Sbjct: 977 LQHEFDLLK---KENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETE 1033
Query: 526 VDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEK 585
+ ++ + ++ VT K E + LK + EK L R +L KL +EE+
Sbjct: 1034 RGEVEEDKENKEYSEKCVTSKCQEIE---IYLKQTISEKEVELQHIRKDLEEKLAAEEQF 1090
Query: 586 SSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQ 645
+ + L+ + + I+ ++ EI+ ++ +T D + + +K+ +
Sbjct: 1091 QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGD---SVALVKETVVI 1147
Query: 646 LEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAE 705
G +E +LE+K + + L ++L+E + KAI K +QE E
Sbjct: 1148 SPPCTGS---SEHWKPELEEKILALEKEKEQLQKKLQEA---LTSRKAILKK---AQEKE 1198
Query: 706 LRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQV 746
R L++ K D + E+ E N DQL QLQ+
Sbjct: 1199 RHLREELKQQKD-DYNRLQEQFDEQSKENENIGDQLRQLQI 1238
Score = 79.0 bits (193), Expect = 3e-14
Identities = 204/1057 (19%), Positives = 419/1057 (39%), Gaps = 154/1057 (14%)
Query: 45 KEDDVMASGTVKRHLKTSGE--CERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLK 102
KE +V+ RH+ + E + ++K LE++K D QLL L+ + DV + +
Sbjct: 843 KESEVLEGAERVRHISSKVEELSQALSQKELEITKMD--QLL------LEKKRDVETLQQ 894
Query: 103 T-EKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQE----------KSIGEDVYEKPISEL 151
T E+ +V E + E K++++ L E S E+ ++ + E
Sbjct: 895 TIEEKDQQVTEISFSMTE--KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEED 952
Query: 152 DRLEEKQKETYRRMLE--QLLLAEKCHRRTVYELENEKHKH---TDYMNKSDDFTNL--L 204
+ + K+ Y M Q+ E H + + ENE+ K +N+ + + L
Sbjct: 953 NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRL 1012
Query: 205 EQERERLKK-------LLEQEKAYQARKEKENAKRLNK-LRDELVKLKSFALMLVDERQM 256
E+E LK L E E+ + ++KEN + K + + +++ + + E+++
Sbjct: 1013 EEELANLKDESKKEIPLSETERG-EVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEV 1071
Query: 257 HI--------EQLGLQSQ---KVQDLTQKLREEEEKLKAITSKSKEDR---QKLLKLEVD 302
+ E+L + Q V+ + Q L+++ ++ + ++ E++ QKL+ D
Sbjct: 1072 ELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTD 1131
Query: 303 FEHKAS-RFSQEHEEMNAKLANQESHNR-QLRLKLVGLTQRIEELEETNKNLQKAEEELQ 360
S +E ++ H + +L K++ L + E+L++ K +E L
Sbjct: 1132 ASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQK------KLQEALT 1185
Query: 361 ELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKE 420
+ + K + L E++ + ++ + +E +K + ++LQ + S +
Sbjct: 1186 SRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESID 1245
Query: 421 LRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELE--------- 471
+L Q+ S LEE K+ Q H E NL D + E
Sbjct: 1246 GKLPSTDQQESCSSTPGLEEPLFKATE---QHHTQPVLESNLCPDWPSHSEDASALQGGT 1302
Query: 472 ---VVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNM------------- 515
+K+++KE+E + LE S +LTK KS V + E+ N
Sbjct: 1303 SVAQIKAQLKEIEAEKVELELKVSSTTSELTK-KSEEVFQLQEQINKQGLEIESLKTVSH 1361
Query: 516 ----------------------MEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKK 553
+E +++ + K+D L K ++ V ++ +L E+
Sbjct: 1362 EAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAA 1421
Query: 554 LLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVER---EI 610
L K+++E+ E+ + +L + K +E+ +L + +K++ + I E R +I
Sbjct: 1422 LTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQI 1481
Query: 611 TRG-RSRKGSELTCPEDNKI--KELTL---EIERLKKRLQQLE-----------VVEGDL 653
R ++ S ++NK +EL+L IERL K L +E V G L
Sbjct: 1482 QRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRL 1541
Query: 654 MKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLE 713
++E D+L + + LS E +K +A E E + +E E ++
Sbjct: 1542 ALLQEERDKLITEMDRSLLENQSLSSSCESLK--LALEGLTEDKEKLVKEIESLKSSKIA 1599
Query: 714 EA-----KSRDLKAEVQALKEKIHELMNKEDQLSQ----LQVDYSVLQQRFMEEENKNKN 764
E+ K ++L+ E + L + + N+ +++ ++ + L + E K
Sbjct: 1600 ESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKE 1659
Query: 765 MGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDA-VSGEAAEEETPAVF 823
+++ +E+E K R S ++++++ + ++ + +G+ A+E +
Sbjct: 1660 TEKQLQEAEQEMEEMKEKMRKFAKS-KQQKILELEEENDRLRAEVHPAGDTAKECMETLL 1718
Query: 824 IRKSFQEENHIMSNLRQVGLKKPVERSSVLDRYPPAANELTMRKSWIPWMRKRENGPSIT 883
+ +E + L K + S++ + E+ K I ++ T
Sbjct: 1719 SSNASMKEELERVKMEYETLSKKFQ--SLMSEKDSLSEEVQDLKHQIEGNVSKQANLEAT 1776
Query: 884 QEKGPRTNSSPGHPGEVVLSPKQGQPLHIRVTPDHENSTATLEITSPTSEEFFSS----T 939
++ +TN + + ++ L + P S + + +P + FSS
Sbjct: 1777 EKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEIN 1836
Query: 940 TVIPTLGNQKPRITIIPSPNVMPQKQKSGDTTLGPER 976
+ + K RI + QK K TL E+
Sbjct: 1837 NYLQQIDQLKERIAGLEEEK---QKNKEFSQTLENEK 1870
Score = 77.4 bits (189), Expect = 8e-14
Identities = 111/563 (19%), Positives = 243/563 (43%), Gaps = 51/563 (9%)
Query: 205 EQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQ 264
EQ LK ++ Q+ +K++ + +++ KLK A + +IE++ Q
Sbjct: 58 EQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQ 117
Query: 265 SQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQ 324
V + EE+L S E+ ++ K++ + K S ++ A Q
Sbjct: 118 GGTVLPTEP---QSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQ 174
Query: 325 ESHNRQLRLKLVGLTQRIEELEETNKNLQ------KAEEELQE-LRDKIAKGECGNSSLM 377
+ + + V + Q+++E EE LQ +AE+ Q+ +R+K A+ E
Sbjct: 175 PAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFE------- 227
Query: 378 AEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEK 437
+V +L++ + + T+ + + R L++KL+E E V+ LQ+ ++ E+
Sbjct: 228 TQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQ 287
Query: 438 ----LEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELS 493
L + + ++E L +E E+ +K LL ++E+ V E + S L++
Sbjct: 288 RNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMEL---EVAERKLSFHNLQEEMHH 344
Query: 494 LKDDLTKLKSFTVMLVDERKNMMEKIKQE-ERKVDGLNKNFKVEQGKVMDVTEKLIEESK 552
L + + L + +K K E E K + K Q ++ + L +++
Sbjct: 345 LLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQ-ELQSACDALKDQNS 403
Query: 553 KLLKLKSE-----------MEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLD 601
KLL+ K+E +E+++ ++E + + +L ++ +++ + D+ +
Sbjct: 404 KLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQ 463
Query: 602 GIEE-----VEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKT 656
+ E +++ + + KG+ L +++EL E E+L ++ LE + +
Sbjct: 464 AVTEENIASLQKRVVELENEKGALLL--SSIELEELKAENEKLSSQITLLE-AQNRTGEA 520
Query: 657 EDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAK 716
+ E ++ + D AN S EE + +N +K + +S L + EE
Sbjct: 521 DREVSEI-----SIVDIANKRSSSAEESGQDVLENTFSQKHKELS-VLLLEMKEAQEEIA 574
Query: 717 SRDLKAEVQALKEKIHELMNKED 739
L+ + + +E HE++++++
Sbjct: 575 FLKLQLQGKRAEEADHEVLDQKE 597
Score = 71.6 bits (174), Expect = 4e-12
Identities = 134/676 (19%), Positives = 266/676 (39%), Gaps = 119/676 (17%)
Query: 66 ERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLR 125
E K K+S E + EDL + + ++ E Q I LK ++ L + + E L
Sbjct: 2573 EEKLKESEE-ANEDLRRSFNALQEEKQDLSKEIESLKVSISQ---LTRQVTALQEEGTLG 2628
Query: 126 VLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELEN 185
+ H AQ K V E+ + L L ++ + E+L+ +K + V E+E+
Sbjct: 2629 LYH-----AQLK-----VKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIED 2678
Query: 186 EKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAK-RLNKLRDELVKLK 244
+ K +++ A R E E A+ R+ +L +LV+++
Sbjct: 2679 KLKKELKHLHHD----------------------AGIMRNETETAEERVAELARDLVEME 2716
Query: 245 SFALMLVDERQ---MHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKED-----RQKL 296
LM+ E + I+ G +Q+ EE ++LK S ++ Q L
Sbjct: 2717 QKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGL 2776
Query: 297 LKLEVDFEHKASRFSQEH---------EEMNAKLANQESHNRQLRLKLVGLTQRIEELEE 347
L E D + FS E++N +L +++ L +L +++ +
Sbjct: 2777 LNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSK 2836
Query: 348 TNKNLQ--------------KAEE--------------ELQELRDKIAKGECGNSSLMAE 379
+LQ K+EE E+Q L+ ++ + L+ E
Sbjct: 2837 AMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKE 2896
Query: 380 VENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLE 439
++NL+++ L++ + E+ ++Q +E + K + + +ELR E Q + +L +
Sbjct: 2897 LKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEK 2956
Query: 440 EAFSKSKSECTQLHLNL--EKEKNLT--KDLLNELEVVKSRVKELECSESRLEKAELSLK 495
++ + + +L +K++ L+ ++L+ EL S+ + L+ R E S
Sbjct: 2957 SSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSAS 3016
Query: 496 DDLTK-LKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKL 554
D ++ L T +L + + +++I Q+E ++ LN NF +L+EE L
Sbjct: 3017 PDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNF-----------SQLLEEKNTL 3065
Query: 555 LKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGR 614
+ + + RE + G L + C+V +E+ +E+ G
Sbjct: 3066 SIQLCDTSQSL----RENQQHYGDLLNH--------CAV---------LEKQVQELQAGP 3104
Query: 615 SRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKA 674
P++ + E L++ Q + L T E ++L + E+D+
Sbjct: 3105 LNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQR 3164
Query: 675 NFLSQQLEEIKHQIAK 690
L + QI +
Sbjct: 3165 VAAENALSVAEEQIRR 3180
Score = 62.4 bits (150), Expect = 3e-09
Identities = 73/397 (18%), Positives = 170/397 (42%), Gaps = 43/397 (10%)
Query: 396 EITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLN 455
E++ + + +R L E H ++ + L E+ + K Q +
Sbjct: 15 ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQ 74
Query: 456 LEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNM 515
L+++ ++ E + ++++++K +L K LT L + + + +
Sbjct: 75 LQQKDEALQE-------------ERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTV 121
Query: 516 MEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEME----EKVYNLTRE 571
+ Q E ++ +K+ E+ ++ + KL E+ + + L++++ E+ + E
Sbjct: 122 LPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTE 181
Query: 572 RDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKE 631
+E + +K + ++ E ++ + + ++ + +R +++ ED ++
Sbjct: 182 MEEFV-MMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQL 240
Query: 632 LT---LEIE---RLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLE--E 683
+T +E E +L+ ++LE E L+ D L+Q+ + + LSQQL+ E
Sbjct: 241 VTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQME 300
Query: 684 IKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQ 743
+H +N V ++ E + E + + K L+E++H L+ + +Q Q
Sbjct: 301 AEHNTLRN------TVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQ 354
Query: 744 LQVD----YSVLQQRF---MEEENKN----KNMGQEV 769
Q + YS L+Q+ MEE+ + + GQE+
Sbjct: 355 AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQEL 391
Score = 59.7 bits (143), Expect = 2e-08
Identities = 111/539 (20%), Positives = 238/539 (44%), Gaps = 72/539 (13%)
Query: 300 EVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKN----LQKA 355
+ D +A + H+E + + N + Q RL Q + EL++ + LQ+
Sbjct: 21 DTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYA--EQLVVELKDIIRQKDVQLQQK 78
Query: 356 EEELQELRDKIAKGECGNSSLMAEVE--NLRKRVLEMEGK------------------DE 395
+E LQE R K A + L A+ + +L K + EM+ + D+
Sbjct: 79 DEALQEER-KAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDK 137
Query: 396 EITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSK-SECTQLHL 454
T+ E + +++ KLQE+E EL + LQ ++++ + + A S ++ E +
Sbjct: 138 SSTEEEMEIEKIKHKLQEKE----EL---ISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQ 190
Query: 455 NLEKEKNLTKDL---LNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDE 511
L++++ L L++ + ++ + + ++R E +D+L +L V D
Sbjct: 191 QLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQL----VTQADV 246
Query: 512 RKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLI---EESKKLLKLKSEMEEKVYNL 568
M +K++ +RK++ ++ V + +V+D+ ++ + E+ ++L + + E +N
Sbjct: 247 ETEMQQKLRVLQRKLEEHEESL-VGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNT 305
Query: 569 TR-----ERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTC 623
R ER+E L+ E + +E S L++ + + E + + ++ S +
Sbjct: 306 LRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSA 365
Query: 624 PEDN---KIKELTLEIERLKKRLQQLE-----VVEGDLMKTEDEYDQLEQKFRTEQDKAN 675
E +++E T I L+K Q+L+ + + + +D+ +Q Q +T Q +
Sbjct: 366 LEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLED 425
Query: 676 FLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELM 735
L Q+ +EI Q +++ E SQ + E + + +L++++ EL
Sbjct: 426 QLQQKSKEIS-QFLNRLPLQQHETASQTS---FPDVYNEGTQAVTEENIASLQKRVVELE 481
Query: 736 NKED-------QLSQLQVDYSVL--QQRFMEEENKNKNMGQEVLNLTKELELSKRYSRA 785
N++ +L +L+ + L Q +E +N+ +EV ++ +KR S A
Sbjct: 482 NEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA 540
Score = 47.4 bits (111), Expect = 8e-05
Identities = 91/448 (20%), Positives = 174/448 (38%), Gaps = 61/448 (13%)
Query: 29 EKSLSEDAKKKKKS--NRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKED--LIQLL 84
+ SL E A+ K++ NR+ D +++ + K + +L +D L+ L
Sbjct: 2762 DASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLS 2821
Query: 85 SIME---GELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGE 141
S +E ++Q+ + L+ E+ + +E K A+ +S+
Sbjct: 2822 SQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSL-- 2879
Query: 142 DVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFT 201
+K +S L ++ + + + +Q L + + EL K + +Y +K+ F
Sbjct: 2880 ---KKAMSSLQNDRDRLLKELKNLQQQYLQINQ----EITELHPLKAQLQEYQDKTKAFQ 2932
Query: 202 NLLEQERERLKKLLEQEKAYQARKEK-------------------ENAKRLNKLRDELVK 242
+ QE R + L Q + +Q R EK + ++L+ L++ + +
Sbjct: 2933 --IMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRE 2990
Query: 243 LKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKS-KEDRQKLLKLEV 301
L+S + + + Q ++ D +Q L E E L+ + S KE QK L+++
Sbjct: 2991 LRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQ- 3049
Query: 302 DFEHKASRFSQEHEEMNA----------KLANQESHNRQLRLKLVGLTQRIEELEETNKN 351
S FSQ EE N L + H L L ++++EL+ N
Sbjct: 3050 ---QLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLN 3106
Query: 352 LQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKL 411
+ A QE K ++ E LR+ +++ T + ELRK L
Sbjct: 3107 IDVAPGAPQEKNGVHRK---------SDPEELREPQQSFSEAQQQLCNTRQEVNELRKLL 3157
Query: 412 QEEEHHSKELRLEVEKLQKRMSELEKLE 439
+EE + ++++ LE E
Sbjct: 3158 EEERDQRVAAENALSVAEEQIRRLEHSE 3185
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 120 bits (300), Expect = 1e-26
Identities = 160/789 (20%), Positives = 330/789 (41%), Gaps = 109/789 (13%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSL-----ELSKEDLIQL 83
E+ + E+ + + D+ + G + + E +KSL EL+ L++L
Sbjct: 406 EELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL 465
Query: 84 LSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDV 143
E E Q+ + L+T E G+A K+L++ + L+++ I E+
Sbjct: 466 ----EMENQSLTKTVEELRTTVDSVE------GNAS--KILKMEKENQRLSKKVEILEN- 512
Query: 144 YEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNL 203
+ ++EKQ + L + L+ EK E E S+ +
Sbjct: 513 --------EIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN---------SERQIKI 555
Query: 204 LEQERERLKKL---LEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQ 260
LEQE E L + L Q A ++ ++ NK+ E +K S L ++ + I++
Sbjct: 556 LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKK 615
Query: 261 LGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEM--- 317
+ + ++ ++ E E +L + +++ ++K+ L++ E K QE+ E+
Sbjct: 616 ---ELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCE-KIEALEQENSELERE 671
Query: 318 NAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLM 377
N KL + L +L L + +L+E N L++ E L+ K+A+ + N L
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
Query: 378 AEVENLRKRV--------------LEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRL 423
+E E L+K + + +G D E + + KK+Q+ E ++L +
Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 424 EVEKLQKRMSE-------LEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSR 476
E + LQK + E LE+LE+ + E +QL + ++ + K L + E+ +
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 477 VKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVE 536
++E LEK +L ++ K V ++K+ E++ L K ++
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCV-----------RLKELEKENKELVKRATID 900
Query: 537 QGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTR---ERDELIGKLKSEEEKSSELSCSV 593
++ + E L+ E K ++ +++E+ + L + ++ L+ +S +++ L +
Sbjct: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL 960
Query: 594 DLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEG-- 651
+ K+ I+E + R + + ++K + E LK+R + +V+
Sbjct: 961 ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP 1020
Query: 652 ------------------DLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKA 693
+L+K +D ++E+ T Q + L QL++++ Q N
Sbjct: 1021 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ-NNNLQ 1079
Query: 694 IEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQ 753
+ + Q L+ + + ++ L+ E L + LMN+ QL ++QQ
Sbjct: 1080 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL--------LIQQ 1131
Query: 754 RFMEEENKN 762
+E EN++
Sbjct: 1132 SSLENENES 1140
Score = 117 bits (293), Expect = 7e-26
Identities = 150/623 (24%), Positives = 286/623 (45%), Gaps = 90/623 (14%)
Query: 204 LEQERERL---KKLLEQEKAYQARKEKEN------AKRLNKLRDELVKLKSFALMLVDER 254
LE++ E+L K+ LEQ + R ++EN A+ RDEL L+ A+ VD+
Sbjct: 267 LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVR-VDKL 325
Query: 255 QMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEH 314
+ + + +++ D+ E KA + KED Q LL+ + E +
Sbjct: 326 ESEVSRY---KERLHDI--------EFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS 374
Query: 315 EEMNAKLANQESHNRQLRLKLVGLT-------QRIEELEETNKNLQKAEE---------- 357
+ KL E N QL+ KL + ++IEEL E N L+ A++
Sbjct: 375 D----KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430
Query: 358 -ELQELRDKIAKGECGNSSLMAEVENLRK-RVLEMEGKDEEITKTESQCRELRKKLQEEE 415
EL+++ E SL EV L R+L++E +++ +TKT ELR + E
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT---VEELRTTVDSVE 487
Query: 416 HHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKS 475
++ ++ L++EK +R+S+ ++ E +E Q +L+ +NL+KDL+ E ++
Sbjct: 488 GNASKI-LKMEKENQRLSKKVEILE------NEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 476 RVKELECSESR----LEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNK 531
++ L + R LE+ L ++ L+ + + + R +EK E K+ L++
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK----ENKI--LHE 594
Query: 532 NFKVEQGKVMDVT------EKLIEESKKLLKLKSEMEEKVYNLTRERDEL---------- 575
+ K K+ + +K +E K+ + E+E ++++L +E + L
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKIT 654
Query: 576 IGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLE 635
K+++ E+++SEL LKK LD + + ++ ++ S+L D + EL
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQL-ESLEKENSQL----DEENLELRRN 709
Query: 636 IERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIE 695
+E LK ++ ++ + + E E +QL++ E KA+F + E+ +Q IE
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGL--ELLKASFKKTERLEVSYQ---GLDIE 764
Query: 696 KGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRF 755
+ + + E++ +DL+ E Q L++ + EL +L QL+ + L+Q
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQET 824
Query: 756 MEEENKNKNMGQEVLNLTKELEL 778
+ E K + +E L ++ E+
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEI 847
Score = 115 bits (287), Expect = 3e-25
Identities = 191/824 (23%), Positives = 363/824 (44%), Gaps = 112/824 (13%)
Query: 10 SASDGHISCPKPSIIGNAGEKSLS---EDAKKKKKSNRKEDDVMASGTVKRHLKTSGECE 66
++S C P + + LS DAK K + R+E ++ L E E
Sbjct: 227 ASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQE----LEEKTEQLLDCKQELE 282
Query: 67 RKTKKSLELSKEDLIQLLS------IMEGELQA-REDVIHMLKTEKTKPEVLEA-HYGSA 118
+ + L +E++ LLS + EL A RE + + K E E H
Sbjct: 283 QMEIELKRLQQENM-NLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEF 341
Query: 119 EPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKET--YRRMLEQLLLAEKCH 176
+V + + +L + K++ ED E + D+L E +KE + L + +
Sbjct: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD 401
Query: 177 RRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKE----NAKR 232
R+ + EL E +S D + L E E++ + E +A Q E + R
Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR 461
Query: 233 LNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDL---TQKLREEEEKLKAITSKS 289
L KL E L V+E + ++ + + K+ + Q+L ++ E L+ +
Sbjct: 462 LLKLEMENQSLTK----TVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE 517
Query: 290 KEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETN 349
K+ Q L D + ++ + E + +E+ RQ+++ L Q E L +T
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETL------RENSERQIKI----LEQENEHLNQTV 567
Query: 350 KNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRK 409
+L++ + E R K + E N L ++ ++ ++E + +I K +E +
Sbjct: 568 SSLRQRSQISAEARVKDIEKE--NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE 625
Query: 410 KLQEEEHHSKELRLEVEKLQKRMSEL----EKLEEAFSKSKSECTQLHLNLEKEKNLTKD 465
+ +E E+ L E E LQK+++ L EK+ EA + SE LE+E K
Sbjct: 626 RAEELENELHHLEKENELLQKKITNLKITCEKI-EALEQENSE-------LERENRKLKK 677
Query: 466 LLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVD---ERKNMMEKIKQE 522
L+ + + +++ LE S+L++ L L+ ++ LK ++ + E K + + +Q
Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
Query: 523 ERKVDGLNKNF-KVEQGKV----MDV----TEKLIEES-KKLLKLKSEMEE-KVYNLTRE 571
++ ++ L +F K E+ +V +D+ +K +E S KK+ +L+SE+++ ++ N T +
Sbjct: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQ 797
Query: 572 RDELIGKLKSEEEKSSELSCSVDLLKKRLDGIE----EVEREITRGRSRKGSELTCPEDN 627
++ + +LK ++ +L L++ +E ++E+E R R + + T E+N
Sbjct: 798 KN--LEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 855
Query: 628 KIKELTLEIER--LKK----------RLQQLEVVEGDLMKTED---------EYDQLEQK 666
+K LE E L K RL++LE +L+K D + +K
Sbjct: 856 NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEK 915
Query: 667 FRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEA-------KSRD 719
+T+Q ++ LE++ H++ K + K ++ E R++L E+ KS +
Sbjct: 916 LKTQQ-----MNNDLEKLTHELEK-IGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLE 969
Query: 720 LKAE-VQALKEKIHELMNKEDQLSQ----LQVDYSVLQQRFMEE 758
+K E + AL+ ++ E N QL Q ++ +Y L+QR EE
Sbjct: 970 IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEE 1013
Score = 114 bits (285), Expect = 6e-25
Identities = 183/850 (21%), Positives = 368/850 (43%), Gaps = 146/850 (17%)
Query: 30 KSLSEDAKKKKKSNRKEDDVMASGTVKR---------HL-KTSGECERKTKKSLELSKED 79
++LS+D K+K K + + + ++ HL +T ++++ S E +D
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584
Query: 80 LIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYG-----SAEPEKVLRVLHRDAILA 134
+ + I+ ++ + ++ EK + + HY + E E L L ++ L
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL 644
Query: 135 QEKSIGEDV-------YEKPISELDRLEEKQKET---YRRMLEQLLLAEKCH-------- 176
Q+K + E+ SEL+R K K+T ++ + QL EK +
Sbjct: 645 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL 704
Query: 177 --RRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKA-----------YQA 223
RR V L+ K ++ + LE E+E+LKK LE KA YQ
Sbjct: 705 ELRRNVESLKCASMKMAQLQLENKE----LESEKEQLKKGLELLKASFKKTERLEVSYQG 760
Query: 224 --------RKEKENA-KRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQK 274
+K EN+ K++ +L EL L+ M Q ++E+L + S++++ +
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQDLE----MENQTLQKNLEELKISSKRLE----Q 812
Query: 275 LREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLK 334
L +E + L+ TS+ ++D+++L K +A EE N K+ N E N+ L K
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLS-K 871
Query: 335 LVGLTQ----RIEELEETNKNL-------------------------QKAEEELQELRDK 365
+G+ + R++ELE+ NK L Q+ +L++L +
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931
Query: 366 IAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRE-----LRKKLQEEEHHSKE 420
+ K L+ + ++ R +E K E K + +E L +L+E +++++
Sbjct: 932 LEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 991
Query: 421 LRLEVEKLQKRMSELEKL--EEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVK 478
LR E++ ++K L++ EE +S + E+E +++ EL VK R+
Sbjct: 992 LRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE---SQETTRELLKVKDRLI 1048
Query: 479 ELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEK---IKQEERKVDGLNKNFKV 535
E+E + + L+ + +LK L +L++ L + + + ++++ + N +V
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108
Query: 536 EQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDL 595
E + + L+ ++ +LL +S +E + ++ +ER++L S + +L +L
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL----EL 1164
Query: 596 LKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMK 655
L +R E E I++ + K + K L +E L+ R QL +K
Sbjct: 1165 LHERQ--ASEYESLISKHGTLKSAH---------KNLEVEHRDLEDRYNQL-------LK 1206
Query: 656 TEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEA 715
+ + + LE+ + EQ+K LE H+ A E ++ + L H +
Sbjct: 1207 QKGQLEDLEKMLKVEQEK-----MLLENKNHETV---AAEYKKLCGENDRLNHTYSQLLK 1258
Query: 716 KSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFME---EENKNKNMGQEVLNL 772
++ L+ + + LK ++ N + + ++L+ ++S L++++ + K N + + L
Sbjct: 1259 ETEVLQTDHKNLKSLLN---NSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL 1315
Query: 773 TKELELSKRY 782
LE R+
Sbjct: 1316 KGNLEEENRH 1325
Score = 102 bits (253), Expect = 3e-21
Identities = 144/661 (21%), Positives = 285/661 (43%), Gaps = 83/661 (12%)
Query: 243 LKSFAL---MLVDERQMHIE---QLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKL 296
LK+ AL L+DER H E +L + + L + + K E RQ L
Sbjct: 190 LKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHL 249
Query: 297 LKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAE 356
D + K R QE EE +L + + Q+ ++L L Q L ++ +
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 357 EELQELRDKIAKGECGNSSL------MAEVENLRKRVLEMEGKDEEITKTESQ------- 403
+EL LR+K + + S + + ++E + RV E++ ++ + +T++
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEG 369
Query: 404 CRELRKKLQEEEHHSKELR-----------LEVEKLQKRMSELEKLEEAFSKSKSECTQL 452
R KL E E + +L+ ++ +K+++ M E LE A +S E L
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE--SL 427
Query: 453 HLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDER 512
HL E E+ L+E + E + SRL K E+ LTK VD
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME-NQSLTKTVEELRTTVDSV 486
Query: 513 KNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKL---IEESKKLLKLKSEMEEKVYNLT 569
+ KI + E++ L+K ++ + +++ + L SK L+K K+++E+ + L
Sbjct: 487 EGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETL- 545
Query: 570 RERDELIGKLKSEEEKSSELSCSVDLLKK--------RLDGIEEVEREITRGRSRKGSEL 621
RE E ++K E+++ L+ +V L++ R+ IE+ + + S+L
Sbjct: 546 RENSE--RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL 603
Query: 622 TCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRT-----------E 670
+ E K +++ E+E K++ ++ E +E +L E E + L++K E
Sbjct: 604 SKIEFEK-RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 671 QDKANF------LSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAK-------- 716
Q+ + L + L+ K+ + +++EK E L R +E K
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
Query: 717 ----SRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNL 772
+++L++E + LK+ + L + +L+V Y L + +N +++ L
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 773 TKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAV-FIRKSFQEE 831
EL+ + ++ L+ + + ++ ++S ++ ++ E+ET + +K ++E
Sbjct: 783 ESELQDLEMENQTLQ-----KNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE 837
Query: 832 N 832
N
Sbjct: 838 N 838
Score = 77.8 bits (190), Expect = 6e-14
Identities = 124/599 (20%), Positives = 261/599 (43%), Gaps = 93/599 (15%)
Query: 32 LSEDAKKKKKSNRK------------EDDVMASGTVKRHLKTSGE--------CERKTKK 71
L +D K+ +K N++ E++ + G +++ KT + C R K
Sbjct: 827 LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL--K 884
Query: 72 SLELSKEDLIQLLSI-MEGELQAREDVI-HMLKTEKTKPEVLEAHYGSAEPEKVLRVLHR 129
LE ++L++ +I ++ + RED++ LKT++ ++ + + E EK+ L++
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH---ELEKI--GLNK 939
Query: 130 DAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHK 189
+ +L E+S +D Y+ LE K + T ++ LE + EK + LE +
Sbjct: 940 ERLLHDEQST-DDRYKL-------LESKLESTLKKSLE--IKEEK-----IAALEARLEE 984
Query: 190 HTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQA------------RKEKENAKRLNKLR 237
T+Y + +++ E LK+ ++E+ Q+ R+ +E + L K++
Sbjct: 985 STNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK 1044
Query: 238 DELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLL 297
D L++++ L E+Q QL ++L + L+A + L
Sbjct: 1045 DRLIEVERNNATLQAEKQALKTQL-----------KQLETQNNNLQAQILALQRQTVSLQ 1093
Query: 298 KLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEE 357
+ + + ++ E+ +N++ + + N QL ++ LE N+++ K E
Sbjct: 1094 EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ-------SSLENENESVIKERE 1146
Query: 358 ELQELRDKIAKG----ECGNSSLMAEVENLRKR--VLEMEGKDEEITKTESQCR--ELRK 409
+L+ L D + K E + +E E+L + L+ K+ E+ + + R +L K
Sbjct: 1147 DLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLK 1206
Query: 410 KLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNE 469
+ + E K L++E EK+ E + + K E +L+ + T+ L +
Sbjct: 1207 QKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD 1266
Query: 470 LEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGL 529
+ +KS + + ++RLE LK+ +L + L N E + Q L
Sbjct: 1267 HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL----NNQCELLSQ-------L 1315
Query: 530 NKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSE 588
N + E ++D + L+ +++ LL+ E ++ + R+ + + +L+ ++EK E
Sbjct: 1316 KGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEE 1374
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 119 bits (299), Expect = 1e-26
Identities = 173/841 (20%), Positives = 356/841 (42%), Gaps = 103/841 (12%)
Query: 68 KTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEV-LEAHYGSAEPEKVLRV 126
K KK+L+ + + + +LQ ED ++ L K K E ++ GS E EK +R+
Sbjct: 996 KEKKALQEAHQQALD-------DLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRM 1048
Query: 127 LHRDAILAQEKSIGE-DVYEKPISELD----RLEEKQK-------------ETYRRMLEQ 168
D A+ K G+ + ++ I +L+ +LEEK K E + + Q
Sbjct: 1049 ---DLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQ 1105
Query: 169 LLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQE---KAYQARK 225
L K ++ + ELE E K + + L +E E + + LE+ + Q
Sbjct: 1106 LQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1165
Query: 226 EKENAKRLNKLRDEL----VKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEK 281
K+ K+R +L ++ ++ A L + + +LG Q +Q + QKL +E+ +
Sbjct: 1166 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1225
Query: 282 LKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQR 341
K + ++++K + + E + + E KL + + L T +
Sbjct: 1226 FKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKL-------EEAQRSLNDFTTQ 1278
Query: 342 IEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEE----- 396
+L+ N L + EE + L ++ +G+ + M ++ KR LE EGK +
Sbjct: 1279 RAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDL----KRQLEEEGKAKNALAHA 1334
Query: 397 ITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNL 456
+ C LR++ +EE EL+ + K +++ E + ++E +L
Sbjct: 1335 LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTE--ELEEAK 1392
Query: 457 EKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMM 516
+K +D +E V ++ LE ++ RL+ L D+ + + L D+++
Sbjct: 1393 KKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAAL-DKKQRNF 1451
Query: 517 EKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLT---RERD 573
+KI E ++ ++ Q ++ ++ S +L KLK+ EE + +L RE
Sbjct: 1452 DKILAEWKQ------KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK 1505
Query: 574 ELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELT 633
L ++ E+ E +V L+K +E + E+ + L E+ KI
Sbjct: 1506 NLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLE-HEEGKILRAQ 1564
Query: 634 LEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLE---EIKHQIAK 690
LE ++K +++ K ++ +++EQ R Q + L L+ ++++ +
Sbjct: 1565 LEFNQIKAEIER---------KLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLR 1615
Query: 691 NKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKE---KIHELMNKEDQLSQ---- 743
K +G++ E +L H R+ + +K+ LK+ ++ + + D L +
Sbjct: 1616 VKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1675
Query: 744 -------LQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMV 796
LQ + L+ + E K QE++ ++ ++L + +L +N ++ +
Sbjct: 1676 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL---INQKKKM 1732
Query: 797 DVPVTSTGVQTDAVSGEA--AEEE-----TPAVFIRKSFQEENHIMSNLRQVGLKKPVER 849
+ +T + + E AEE+ T A + + ++E ++L + +KK +E+
Sbjct: 1733 ESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER--MKKNMEQ 1790
Query: 850 S 850
+
Sbjct: 1791 T 1791
Score = 108 bits (271), Expect = 2e-23
Identities = 210/927 (22%), Positives = 394/927 (42%), Gaps = 161/927 (17%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKK---SLELSKEDLIQLLS 85
E ++ +K K K ++ DD+ G++++ K + ER +K L+L++E ++ L +
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDL--EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN 1073
Query: 86 I---MEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGED 142
+E +L+ +E I+ ++ +VL E R+ + L E++
Sbjct: 1074 DKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAK 1133
Query: 143 VYEKPISEL--------DRLEE------------KQKET----YRRMLEQLLLAE----- 173
V EK S+L +RLEE K++E RR LE+ L
Sbjct: 1134 V-EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1192
Query: 174 ---KCHRRTVYELENE-----------KHKHTDYMNKSDDFTNLLEQ------ERERLKK 213
K H +V EL + + + +++ + DD T+ +EQ E++ +
Sbjct: 1193 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSR 1252
Query: 214 LLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALML---VDERQMHIEQLGL----QSQ 266
LE + K +E + LN + KL++ L ++E++ I QL +Q
Sbjct: 1253 TLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQ 1312
Query: 267 KVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQES 326
+++DL ++L EE + A+ + R L +E + ++ E+ L+ S
Sbjct: 1313 QMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEE----TEAKAELQRVLSKANS 1368
Query: 327 HNRQLRLKL-VGLTQRIEELEETNKNL----QKAEEELQELRDKIAKGECGNSSLMAEVE 381
Q R K QR EELEE K L Q AEE ++ + K + E L E+E
Sbjct: 1369 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIE 1428
Query: 382 NLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRM----SELEK 437
+L ++++E + + + R K L E + +E + E+E QK +EL K
Sbjct: 1429 DL---MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFK 1485
Query: 438 LEEAFSKSKSECTQL---HLNLEKE-KNLTKDL------LNELEVVKSR--VKELECSES 485
L+ A+ +S + NL++E +LT+ L ++ELE V+ + V++LE +S
Sbjct: 1486 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLEL-QS 1544
Query: 486 RLEKAELSLKDD----------LTKLKSFTVMLVDERKNMMEKIKQE-ERKVDGLNKNFK 534
LE+AE SL+ + ++K+ + E+ ME+ K+ +R VD L +
Sbjct: 1545 ALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLD 1604
Query: 535 VE---QGKVMDVTEKL------------------IEESKKLLKLKSEMEEKVYNL---TR 570
E + +V+ V +K+ E K++ L+S +++ L R
Sbjct: 1605 AETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR 1664
Query: 571 ERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIK 630
D+L + E +++ L ++ L+ ++ E RSRK +E E ++
Sbjct: 1665 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTE---------RSRKLAEQELIETSE-- 1713
Query: 631 ELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFL----SQQLEEIKH 686
+ L + + Q + +E DL + + E ++ Q+ R ++KA + EE+K
Sbjct: 1714 RVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKK 1773
Query: 687 QIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQV 746
+ + +E+ + ++ + RL+EA E ALK +L E ++ +L+
Sbjct: 1774 EQDTSAHLERMKKNMEQTIKDLQHRLDEA-------EQIALKGGKKQLQKLEARVRELEG 1826
Query: 747 DYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQ 806
+ Q+R E + + + LT + E K+ N R+ D+ V ++
Sbjct: 1827 ELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKK---------NLLRLQDL-VDKLQLK 1876
Query: 807 TDAVSGEAAEEETPAVFIRKSFQEENH 833
A +A E E A F++ H
Sbjct: 1877 VKAYKRQAEEAEEQANTNLSKFRKVQH 1903
Score = 106 bits (265), Expect = 1e-22
Identities = 159/755 (21%), Positives = 333/755 (44%), Gaps = 104/755 (13%)
Query: 49 VMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKP 108
++ S ++ + T E + K++LE S+ +L M LQ + D+ ++ E+
Sbjct: 841 LLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL 900
Query: 109 EVLEAHYGSAEPEKV---LRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRM 165
E K+ +V + L E+ + ++ K D E +K+
Sbjct: 901 NDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKD----- 955
Query: 166 LEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARK 225
++ L L T+ ++E EKH NK + T + E + KL +++KA Q
Sbjct: 956 IDDLEL-------TLAKVEKEKHATE---NKVKNLTEEMAGLDEIIAKLTKEKKALQ--- 1002
Query: 226 EKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAI 285
+ + + L+ L+ E K+ S + V Q ++ L ++ + + L + KL+
Sbjct: 1003 -EAHQQALDDLQVEEDKVNSLSKSKVKLEQQ-VDDLEGSLEQEKKVRMDLERAKRKLEGD 1060
Query: 286 TSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEEL 345
++E L ++ E K + + + N+K+ +++ QL+ KL RIEEL
Sbjct: 1061 LKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEEL 1120
Query: 346 EETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEG----KDEEITKTE 401
EEEL+ R AK E S L E+E + +R+ E G + E K E
Sbjct: 1121 ----------EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE 1170
Query: 402 SQCRELRKKLQEE--EHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKE 459
++ +++R+ L+E +H + L +K ++EL + + + K + LEKE
Sbjct: 1171 AEFQKMRRDLEEATLQHEATAAALR-KKHADSVAELGEQIDNLQRVKQK-------LEKE 1222
Query: 460 KNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKI 519
K+ + EL+ V S ++++ +++ LEK +L+D + + K+
Sbjct: 1223 KS---EFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYR--------------VKL 1265
Query: 520 KQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKL 579
++ +R ++ +F ++ K+ +L + ++ L S++ + T++ ++L +L
Sbjct: 1266 EEAQRSLN----DFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQL 1321
Query: 580 KSEEEKSSELSCSV-------DLLKKRLDGIEEVEREITRGRSRKGSEL----TCPEDNK 628
+ E + + L+ ++ DLL+++ + E + E+ R S+ SE+ T E +
Sbjct: 1322 EEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDA 1381
Query: 629 IKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQI 688
I+ T E+E KK+L Q L E+ + + K + + + L ++E++ +
Sbjct: 1382 IQR-TEELEEAKKKLAQ------RLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1434
Query: 689 AKNKAIEKGEVVSQE------AELRHRFRLEEAKSRDLKAEVQALKEKIHELMNK-EDQL 741
++ A Q AE + ++ +++ + E ++L ++ +L N E+ L
Sbjct: 1435 ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1494
Query: 742 SQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKEL 776
L+ + +NKN+ +E+ +LT++L
Sbjct: 1495 EHLET-----------FKRENKNLQEEISDLTEQL 1518
Score = 106 bits (265), Expect = 1e-22
Identities = 159/786 (20%), Positives = 341/786 (43%), Gaps = 110/786 (13%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIME 88
E +L +A + D V G +L+ + K K +L +D+ S ME
Sbjct: 1182 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT---SNME 1238
Query: 89 GELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKP- 147
++A+ ++ + +T + + A+ R + + + + EK
Sbjct: 1239 QIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEA 1298
Query: 148 -ISELDRLE---EKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNL 203
IS+L R + +Q E +R LE+ K + L++ +H + ++ T
Sbjct: 1299 LISQLTRGKLSYTQQMEDLKRQLEE---EGKAKNALAHALQSARHDCDLLREQYEEETEA 1355
Query: 204 LEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGL 263
+ + L K + ++ + E + +R +L + KL A L D + +E +
Sbjct: 1356 KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKL---AQRLQDAEEA-VEAVNA 1411
Query: 264 QSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLAN 323
+ ++ +L+ E E L +S L K + +F+ + + Q++EE ++L +
Sbjct: 1412 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1471
Query: 324 QESHNRQLRLKLVGLTQRIEE-------LEETNKNLQKAEEELQELRDKIAKGECGNSSL 376
+ R L +L L EE + NKNLQ EE+ +L +++ +G
Sbjct: 1472 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ---EEISDLTEQLGEG----GKN 1524
Query: 377 MAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVE------KLQK 430
+ E+E +RK++ + E + +S E L+ EE K LR ++E ++++
Sbjct: 1525 VHELEKVRKQL------EVEKLELQSALEEAEASLEHEE--GKILRAQLEFNQIKAEIER 1576
Query: 431 RMSEL-EKLEEAFSKSKSECTQLHLNLEKEKNLTKDLL----------NELEVVKSRV-- 477
+++E E++E+A + L +L+ E ++L NE+E+ S
Sbjct: 1577 KLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANR 1636
Query: 478 ------KELECSESRLEKAELSLKDDLTKLKSF--TVMLVDERKNMMEKIKQEERKV-DG 528
K+++ +S L+ ++ L D + + +V+ R N+++ +E R V +
Sbjct: 1637 MAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQ 1696
Query: 529 LNKNFKVEQGKVMDVTEK---LIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEK 585
++ K+ + ++++ +E+ L ++ L+ K +ME + L E +E + + ++ EEK
Sbjct: 1697 TERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEK 1756
Query: 586 S-----------------SELSCSVDLLKKRLD--------GIEEVEREITRGRSRKGSE 620
+ + S ++ +KK ++ ++E E+ +G ++ +
Sbjct: 1757 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK 1816
Query: 621 LTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQ 680
L + +++EL E+E +KR E V+G + K+E +L ++TE+DK N L Q
Sbjct: 1817 L----EARVRELEGELEAEQKR--NAESVKG-MRKSERRIKEL--TYQTEEDKKNLLRLQ 1867
Query: 681 ----LEEIKHQIAKNKAIEKGEV----VSQEAELRHRFRLEEAKSRDLKAEVQALKEKIH 732
++K + K +A E E +S+ +++H E ++ +++V L+ K
Sbjct: 1868 DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1927
Query: 733 ELMNKE 738
++ K+
Sbjct: 1928 DIGAKQ 1933
Score = 106 bits (264), Expect = 2e-22
Identities = 140/616 (22%), Positives = 263/616 (42%), Gaps = 93/616 (15%)
Query: 295 KLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELE----ETNK 350
K L + E + + +E + L E+ ++L K+V L Q +L+
Sbjct: 839 KPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD 898
Query: 351 NLQKAEEELQEL-RDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEIT----KTESQCR 405
NL AEE +L ++KI L A+V+ + +R+ + E + E+T K E +C
Sbjct: 899 NLNDAEERCDQLIKNKI--------QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECS 950
Query: 406 ELRKKLQ---------EEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNL 456
EL+K + E+E H+ E + V+ L + M+ L+++ +K K + H
Sbjct: 951 ELKKDIDDLELTLAKVEKEKHATENK--VKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1008
Query: 457 EKEKNLTKDLLNELEVVK----SRVKELECSESR-------LEKAELSLKDDLTKLKSFT 505
+ + +D +N L K +V +LE S + LE+A+ L+ DL +
Sbjct: 1009 LDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1068
Query: 506 VMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEME--- 562
+ L +++ + EK+K++E ++ N + EQ + + +KL E ++ +L+ E+E
Sbjct: 1069 MDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAER 1128
Query: 563 ------EKV-YNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVER---EITR 612
EK+ +L+RE +E+ +L EE S +++ KKR +++ R E T
Sbjct: 1129 TARAKVEKLRSDLSRELEEISERL---EEAGGATSVQIEMNKKREAEFQKMRRDLEEATL 1185
Query: 613 GRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYD----------- 661
+ L + + EL +I+ L++ Q+LE + + D+
Sbjct: 1186 QHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1245
Query: 662 QLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLK 721
LE+ RT +D+AN +LEE + + + ++ ++ ++ EL + +EA L
Sbjct: 1246 NLEKVSRTLEDQANEYRVKLEEAQRSL-NDFTTQRAKLQTENGELARQLEEKEALISQLT 1304
Query: 722 AEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVL-------NLTK 774
+ +++ +L +R +EEE K KN L +L +
Sbjct: 1305 RGKLSYTQQMEDL------------------KRQLEEEGKAKNALAHALQSARHDCDLLR 1346
Query: 775 ELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVS-GEAAEEETPAVFIRKSFQEENH 833
E + ++A V + +V T +TDA+ E EE + R EE
Sbjct: 1347 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAV 1406
Query: 834 IMSNLRQVGLKKPVER 849
N + L+K R
Sbjct: 1407 EAVNAKCSSLEKTKHR 1422
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 119 bits (298), Expect = 2e-26
Identities = 180/740 (24%), Positives = 327/740 (44%), Gaps = 114/740 (15%)
Query: 64 ECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHM----LKTEKTKPEVLEAHYGSAE 119
E K S +L E + ++ E Q E ++ K + + E++E +
Sbjct: 677 ELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRS 736
Query: 120 PEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRT 179
E + H LA EK+ +K E + EKQ E LE+ K +T
Sbjct: 737 LETNINTEHEKICLAFEKA------KKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKT 790
Query: 180 VYELENE---KHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKL 236
+ L+ + K H + +++ L E + E K+ +++++A +A + N++
Sbjct: 791 MSMLQQDIICKQHHLESLDRL-----LTESKGEMKKENMKKDEALKALQ--------NQV 837
Query: 237 RDELVKLKSFALMLV---DERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDR 293
+E +K++ L +E +H+ QL +K + +K EE L
Sbjct: 838 SEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCL----------- 886
Query: 294 QKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETN---- 349
QK LK++ + QE E N L + +Q+ L T R ELE+T
Sbjct: 887 QKELKIK-------NHSLQETSEQNVILQHTLQQQQQM---LQQETIRNGELEDTQTKLE 936
Query: 350 KNLQKAEEELQELRD----KIAKGECGNSSLMAEVENLRKRVLEMEGK-----------D 394
K + K E+ELQ+ R+ K+ K E S E + R++V+E+ G
Sbjct: 937 KQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYK 996
Query: 395 EEITKTESQCRELRKKLQEEEHHSKEL-------RLEVEKLQKRMSELEKLEEAFSKSKS 447
EE++K E + L++ + + H +L + E+EK + ELEKL+ +
Sbjct: 997 EELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTE---- 1052
Query: 448 ECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVM 507
T+L L+K + L +L N +KS +++L+ L+KA+LSL++ T +K T
Sbjct: 1053 --TELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAE 1110
Query: 508 LVDERKNMMEKIKQEERKVDGLNK--NFKVEQGKV------MDVTEKLIEESKKLLKL-- 557
L E K +E KQE ++D K N++++Q M + E E +K++KL
Sbjct: 1111 L-RECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEG 1169
Query: 558 ---KSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGR 614
KSE+E K N ++ + L KL++ +E+ E ++ + I ++++EI R +
Sbjct: 1170 TLEKSELELKECN--KQIESLNDKLQNAKEQLREKEF---IMLQNEQEISQLKKEIERTQ 1224
Query: 615 SRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKA 674
R E+ + + + + + Q+L + + + E + + Q +
Sbjct: 1225 QRM-KEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREI 1283
Query: 675 NFLSQQLEEIKHQIAKNK-------AIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQAL 727
LS +LE++K Q++K K A E G +EA L R + E K L AEV++L
Sbjct: 1284 ERLSSELEDMK-QLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKK---LSAEVESL 1339
Query: 728 KEKIH-ELMNKEDQLSQLQV 746
KE H E+++ ++ ++ ++
Sbjct: 1340 KEAYHMEMISHQENHAKWKI 1359
Score = 106 bits (265), Expect = 1e-22
Identities = 129/630 (20%), Positives = 277/630 (43%), Gaps = 76/630 (12%)
Query: 204 LEQERERLK-KLLEQEKAYQARKEK--ENAKRLNKLRDELVKLKSFALMLVDERQMHIEQ 260
+E E LK + + +Q +E+ E A +KL E+ K S L L + + I
Sbjct: 653 IEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVA 712
Query: 261 LGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKL-----------LKLEVDFEHKASR 309
+ K +L Q+L E+ EK++++ + + +K+ L+ + E + R
Sbjct: 713 YSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIER 772
Query: 310 FSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELE--------ETNKNLQKAEEELQE 361
+ E+ + + QE L+ ++ +E L+ E K K +E L+
Sbjct: 773 LEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKA 832
Query: 362 LRDKIAKGECGNSSLMAEVENLRKRVL----EMEGKDEEITKTESQCRE----LRKKLQE 413
L++++++ L + +E ++ ++ ++EG E+ K + E L+K+L+
Sbjct: 833 LQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKI 892
Query: 414 EEHHSKE-----------LRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNL 462
+ H +E L+ + + LQ+ +LE+ +K + + ++L L+K++
Sbjct: 893 KNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRES 952
Query: 463 TKDLLNELEVVKSRVKELECSESRLEKAELSLKD--DLTKLKSFTVMLVDERKNMMEKIK 520
+ + L ++E E ES +A+L + +LT + +D+ K + K++
Sbjct: 953 SAEKLRKME---------EKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKME 1003
Query: 521 QE--ERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERD-ELIG 577
+E K DG NK + Q + +++++K L+ K+ +++ L + EL
Sbjct: 1004 KEIMHLKRDGENKAMHLSQ------LDMILDQTKTELEKKTNAVKELEKLQHSTETELTE 1057
Query: 578 KLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIE 637
L+ E +EL + LK L ++E+ + + + + T IK+LT E+
Sbjct: 1058 ALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTT-----IKDLTAELR 1112
Query: 638 RLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKG 697
K ++E + +L++ + + + + + L + E + ++ + +G
Sbjct: 1113 ECK---MEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEG 1169
Query: 698 EVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFME 757
+ E EL+ + E+ + L+ + L+EK ++ E ++SQL+ + QQR E
Sbjct: 1170 TLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKE 1229
Query: 758 EENKNKNMGQ-------EVLNLTKELELSK 780
E+ K Q E ++L +EL L++
Sbjct: 1230 MESVMKEQEQYIATQYKEAIDLGQELRLTR 1259
Score = 94.7 bits (234), Expect = 5e-19
Identities = 140/709 (19%), Positives = 296/709 (41%), Gaps = 107/709 (15%)
Query: 134 AQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHK---- 189
AQ+++ + E+ I L+ Q + R +L ++K L+ K +
Sbjct: 279 AQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKL 338
Query: 190 HTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALM 249
D + ++ Q E L E KA+Q K+K A++L K++ E L+
Sbjct: 339 KVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKV-AEKLEKVQAEEEILERNLTN 397
Query: 250 LVDERQMHIEQLGLQSQKVQDLTQKLRE-------EEEKLKAITSKSKE-------DRQK 295
E + E+ GL +++ L +KLR+ +EKL+ + K+ E RQ
Sbjct: 398 CEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQS 457
Query: 296 LLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRI----EELEETNKN 351
+LKLE + E+K + MN NR+L++++ +R+ +E+E +
Sbjct: 458 ILKLESELENKDEILRDKFSLMN--------ENRELKVRVAAQNERLDLCQQEIESSRVE 509
Query: 352 LQKAEEELQEL-----------------------RDKIAKGECGNSSLM----------- 377
L+ E+ + +L ++ G C + L+
Sbjct: 510 LRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIK 569
Query: 378 -AEVENLRKRVLEMEGKDEEITKTESQ----------------CRELRKKLQEEEHHSKE 420
AE++ L + + IT +SQ ++ + ++++ H+
Sbjct: 570 EAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMN 629
Query: 421 LRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKEL 480
+ E E+ Q+ ++ +E+L + ++E + L +N+ + + + EL S +L
Sbjct: 630 KQYEKER-QRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKL 688
Query: 481 ECSE----SRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVE 536
E S+L E L++ + S + + +MEK K+ L N E
Sbjct: 689 ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEK----NEKIRSLETNINTE 744
Query: 537 QGKVMDVTEKLIEESKKL-LKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDL 595
K+ EK +KK+ L+ EME+++ L + ++ + K +E+ S L +
Sbjct: 745 HEKICLAFEK----AKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIIC 800
Query: 596 LKKRLDGIE----EVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQL-EVVE 650
+ L+ ++ E + E+ + +K L + N++ E T+++ +L L+ E +
Sbjct: 801 KQHHLESLDRLLTESKGEMKKENMKKDEALKALQ-NQVSEETIKVRQLDSALEICKEELV 859
Query: 651 GDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRF 710
L + E ++ E++ + + ++ L ++L+ H + + + V+ Q + +
Sbjct: 860 LHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQET---SEQNVILQHTLQQQQQ 916
Query: 711 RLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEE 759
L++ R+ E++ + K+ + ++K +Q Q Q + S + R MEE+
Sbjct: 917 MLQQETIRN--GELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEK 963
Score = 77.8 bits (190), Expect = 6e-14
Identities = 121/620 (19%), Positives = 258/620 (41%), Gaps = 91/620 (14%)
Query: 295 KLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQK 354
K+ DF+ K ++M + A + + LR KL L Q+ L N +L
Sbjct: 204 KISGSSTDFQKKP------RDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMT 257
Query: 355 AEE----ELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGK----DEEITKTESQCRE 406
E EL + R K++ E A V L ++++ +E + D+ + + E++ +
Sbjct: 258 KFESIHFELTQSRAKVSMLESAQQQA-ASVPILEEQIINLEAEVSAQDKVLREAENKLEQ 316
Query: 407 LRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDL 466
+K + E+E +E + E KL+ + E K + + ++E L + L+K
Sbjct: 317 SQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEA------LYNAEELSKAF 370
Query: 467 LNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKV 526
+ V ++++++ E LE+ + + + +L+ + E + + EK++Q + +
Sbjct: 371 QQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEEN 430
Query: 527 DGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEK------VYNLTRERDELIGKLK 580
+ + ++ K +V +L E + +LKL+SE+E K ++L E EL ++
Sbjct: 431 NNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVA 490
Query: 581 SEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKG----------SELTCPEDNKI- 629
++ E+ ++ + L +E++ ++ R G S + ED I
Sbjct: 491 AQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIG 550
Query: 630 ----KELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIK 685
+L + R+K +++ E+ + T ++ Q Q+ + S + E +K
Sbjct: 551 CCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVK 610
Query: 686 ---HQIAK----------NKAIEK--GEVVSQEAELRHRFRLEEAKSRDLK-------AE 723
HQ+A+ NK EK +V+ ELR + EA++ DLK ++
Sbjct: 611 LGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQ 670
Query: 724 VQALKE------------------KIHELMNKEDQLSQLQVDYS-------VLQQRFMEE 758
Q ++E K +L+ E QL + V YS L+Q ME+
Sbjct: 671 FQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEK 730
Query: 759 ENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEE 818
K +++ + T+ ++ + +A + + + ++ + Q + + E+E
Sbjct: 731 NEKIRSLETNI--NTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQE 788
Query: 819 TPAVFIRKSFQEENHIMSNL 838
+++ + H + +L
Sbjct: 789 KTMSMLQQDIICKQHHLESL 808
Score = 77.4 bits (189), Expect = 8e-14
Identities = 137/618 (22%), Positives = 253/618 (40%), Gaps = 152/618 (24%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIME 88
++ L+E + KK N K+D+ + + ++ + R+ +LE+ KE+L+ L+ +E
Sbjct: 809 DRLLTESKGEMKKENMKKDEALKA--LQNQVSEETIKVRQLDSALEICKEELVLHLNQLE 866
Query: 89 G-------ELQAREDVIHMLKTE-KTKPEVLEAHYGSAEPEKVLR--------VLHRDAI 132
G +L+ + + ++ L+ E K K L+ ++E +L+ +L ++ I
Sbjct: 867 GNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQE---TSEQNVILQHTLQQQQQMLQQETI 923
Query: 133 LAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCH---------------- 176
E + EK +S+L++ +KQ+E+ L ++ EKC
Sbjct: 924 RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKM--EEKCESAAHEADLKRQKVIEL 981
Query: 177 ----RRTVYELENEK-----------HKHTDYMNKSDDFTNL----------LEQERERL 211
R+ E++ K H D NK+ + L LE++ +
Sbjct: 982 TGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAV 1041
Query: 212 KKL--------LEQEKAYQARK----EKENA--------KRLNKLRDELVKLKSFALMLV 251
K+L E +A Q R+ E +NA ++L +LRD L K A + +
Sbjct: 1042 KELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQK----AQLSL 1097
Query: 252 DERQMHIEQLGLQ----SQKVQDLTQKLREEEEKLK------------------AITSKS 289
+E+ I+ L + +++D Q+L E ++ LK I
Sbjct: 1098 EEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHR 1157
Query: 290 KEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETN 349
E QK++KLE + E E+ K N +++E N
Sbjct: 1158 GEMEQKIIKLE---------GTLEKSELELKECN-------------------KQIESLN 1189
Query: 350 KNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRK 409
LQ A+E+L+E + + E S L E+E ++R+ EME +E Q + +
Sbjct: 1190 DKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKE------QEQYIAT 1243
Query: 410 KLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKD---- 465
+ +E +ELRL E++Q +EL + +++ E +L LE K L+K+
Sbjct: 1244 QYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAH 1303
Query: 466 ---LLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQE 522
L EL K R LE + + E +LS + + K M+ + + KI +
Sbjct: 1304 GNHLAEELGASKVREAHLE-ARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISAD 1362
Query: 523 ERKVDGLNKNFKVEQGKV 540
+K N ++E+ K+
Sbjct: 1363 SQKSSVQQLNEQLEKAKL 1380
Score = 64.3 bits (155), Expect = 7e-10
Identities = 95/441 (21%), Positives = 188/441 (42%), Gaps = 53/441 (12%)
Query: 23 IIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQ 82
+ G A + + D K++ S + E ++M HLK GE K++ LS+ D+I
Sbjct: 981 LTGTARQVKIEMDQYKEELS-KMEKEIM-------HLKRDGE-----NKAMHLSQLDMI- 1026
Query: 83 LLSIMEGELQAREDVI-------HMLKTEKT----KPEVLEAHYGSAEPE--KVLRVLHR 129
L + EL+ + + + H +TE T K EVLE +A E LR L
Sbjct: 1027 -LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQE 1085
Query: 130 DAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHK 189
+ Q+ + + I +L + K ++LL ++ + +EL+ +
Sbjct: 1086 LRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQ 1145
Query: 190 HTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALM 249
T + +EQ+ +L+ LE+ + + KE K++ L D+L K
Sbjct: 1146 VTHLDMTIREHRGEMEQKIIKLEGTLEKSEL----ELKECNKQIESLNDKLQNAK----- 1196
Query: 250 LVDERQMHIEQLGLQS-QKVQDLTQKLREEEEKLKAITSKSKEDRQKLL---KLEVDFEH 305
E+ E + LQ+ Q++ L +++ ++++K + S KE Q + K +D
Sbjct: 1197 ---EQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQ 1253
Query: 306 KASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQEL--R 363
+ ++ + + +LA Q + ++ L+ +E++++ +K L E
Sbjct: 1254 ELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGA 1313
Query: 364 DKI------AKGECGNSSLMAEVENLRKRV-LEMEGKDEEITKTESQCRELRKKLQEEEH 416
K+ A+ + L AEVE+L++ +EM E K + + +Q+
Sbjct: 1314 SKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNE 1373
Query: 417 HSKELRLEVEKLQKRMSELEK 437
++ +LE+E+ Q +S L +
Sbjct: 1374 QLEKAKLELEEAQDTVSNLHQ 1394
Score = 48.9 bits (115), Expect = 3e-05
Identities = 72/385 (18%), Positives = 169/385 (43%), Gaps = 49/385 (12%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIME 88
E L+E +K++ + + A G +K L+ E +K+ +LS E+ + +
Sbjct: 1052 ETELTEALQKREVLETELQN--AHGELKSTLRQLQELRDVLQKA-QLSLEEKYTTIKDLT 1108
Query: 89 GELQAREDVIHMLKTEKTKPEVLEAHYGSAE-----PEKVLRVLHRDAILAQEKSIGEDV 143
EL+ + ++ E K E+LE E ++ +V H D + + + E
Sbjct: 1109 AELRECK-----MEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQK 1163
Query: 144 YEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNL 203
K L++ E + KE +++ E + + E + K + + + L
Sbjct: 1164 IIKLEGTLEKSELELKECNKQI-------ESLNDKLQNAKEQLREKEFIMLQNEQEISQL 1216
Query: 204 ---LEQERERLKKL---LEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMH 257
+E+ ++R+K++ +++++ Y A + KE +LR ++++ L + R
Sbjct: 1217 KKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQ 1276
Query: 258 IE---QLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEH 314
++ ++ S +++D+ Q +E++ + + + + LE + + + S E
Sbjct: 1277 VQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEV 1336
Query: 315 EEMNAK-----LANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAK- 368
E + +++QE+H + K+ +Q+ +++ N+ L+KA+ EL+E +D ++
Sbjct: 1337 ESLKEAYHMEMISHQENH---AKWKISADSQK-SSVQQLNEQLEKAKLELEEAQDTVSNL 1392
Query: 369 ----------GECGNSSLMAEVENL 383
E N +L+ + EN+
Sbjct: 1393 HQQVQDRNEVIEAANEALLTKGENV 1417
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 119 bits (297), Expect = 2e-26
Identities = 179/816 (21%), Positives = 350/816 (42%), Gaps = 122/816 (14%)
Query: 49 VMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKP 108
++ S ++ + T E +KTK L S+ +L + +Q + D+ L+ +
Sbjct: 840 LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDL--QLQVQAESE 897
Query: 109 EVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQ 168
+L+A + K L E++ E+ ++ R E + ++ ++
Sbjct: 898 NLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 957
Query: 169 LLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKE 228
L L T+ ++E EKH NK + T L E + KL ++KA Q +
Sbjct: 958 LEL-------TLAKVEKEKHATE---NKVKNLTEELSGLDETIAKLTREKKALQ----EA 1003
Query: 229 NAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSK 288
+ + L+ L+ E K+ S +++ + +EQ +V+DL L E+E+KL+ +
Sbjct: 1004 HQQALDDLQAEEDKVNS-----LNKTKSKLEQ------QVEDLESSL-EQEKKLRVDLER 1051
Query: 289 SKED--------RQKLLKLEVDFEHKASRFSQ---EHEEMNAKLANQESHNRQLRLKLVG 337
+K ++ +L LE D + R + E+ ++ +K+ ++++ Q + K+
Sbjct: 1052 NKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKE 1111
Query: 338 LTQRIEELEE-----------TNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRK- 385
L RIEELEE T K EL+EL +++ + G +S E+ R+
Sbjct: 1112 LQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG-GVTSTQIELNKKREA 1170
Query: 386 RVLEMEGKDEEIT-KTESQCRELRKK----LQEEEHHSKELRLEVEKLQKRMSELEKLEE 440
L++ EE T + E+ LRKK + E L+ +KL+K SE + +
Sbjct: 1171 EFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEID 1230
Query: 441 AFSKSKSECTQLHLNLEKEKNLTKDLLNEL----EVVKSRVKELECSESRL--EKAEL-- 492
S S ++ NLEK +D L+E E ++ + EL +SRL E EL
Sbjct: 1231 DLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSR 1290
Query: 493 ------SLKDDLTKLKSFTVMLVDERKNMMEK-----------IKQEERKVDGLNKNFKV 535
S+ L++ K +E K +E+ ++ D L + ++
Sbjct: 1291 QLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEE 1350
Query: 536 EQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDE----LIGKLKSEEEKSSELS- 590
EQ ++ L + + ++ + +++ E T E +E L +L+ EE+ ++
Sbjct: 1351 EQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNA 1410
Query: 591 --CSVDLLKKRLDG-IEEVEREITRGRS---------RKGSELTCPEDNKIKELTLEIER 638
S++ K+RL G +E++ ++ R S R ++ K +E E+E
Sbjct: 1411 KCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEA 1470
Query: 639 LKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNK------ 692
K + L +L K ++ Y++ + T + + L Q++ ++ QIA+N
Sbjct: 1471 SLKESRSLST---ELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL 1527
Query: 693 -------AIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKI-HELMNKEDQLSQL 744
+EK ++ E EEAK ++ E+ +K +I ++ K++++ QL
Sbjct: 1528 EKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQL 1587
Query: 745 QVDYS---VLQQRFMEEENKNKNMGQEVLNLTKELE 777
+ +Y Q ++ E +++N E + L K++E
Sbjct: 1588 KRNYQRTVETMQSALDAEVRSRN---EAIRLKKKME 1620
Score = 102 bits (253), Expect = 3e-21
Identities = 158/765 (20%), Positives = 332/765 (43%), Gaps = 90/765 (11%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIME 88
E +L +A + D V G +L+ + K K +L +DL S ME
Sbjct: 1181 EATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLS---SSME 1237
Query: 89 GELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVL--HRDAILAQEKSIGEDVYEK 146
+++ ++ + +T + ++ EA + E ++ L L + + + + + EK
Sbjct: 1238 SVSKSKANLEKICRT--LEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEK 1295
Query: 147 P--ISELDRLEE---KQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFT 201
+S+L R ++ +Q E +R LE+ K + L++ +H + ++
Sbjct: 1296 ESIVSQLSRSKQAFTQQTEELKRQLEE---ENKAKNALAHALQSSRHDCDLLREQYEEEQ 1352
Query: 202 NLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQL 261
+ + L K + ++ + E + +R +L + KL A L D + +E +
Sbjct: 1353 EGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKL---AQRLQDSEEQ-VEAV 1408
Query: 262 GLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKL 321
+ ++ Q+L+ E E L ++ L K + +F+ + + + EE A+L
Sbjct: 1409 NAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAEL 1468
Query: 322 ANQESHNRQLRLKLVGLTQRIEE----LEETNKNLQKAEEELQELRDKIAKGECGNSSLM 377
+R L +L L EE LE + + E+E+ +L ++IA+ N +
Sbjct: 1469 EASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAE----NGKTI 1524
Query: 378 AEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVE----------K 427
E+E RK++ E+E D ++ E++ L+ EE +K LR+++E K
Sbjct: 1525 HELEKSRKQI-ELEKADIQLALEEAEA-----ALEHEE--AKILRIQLELTQVKSEIDRK 1576
Query: 428 LQKRMSELEKLEEAFSKSKSECTQLHLNLE--------KEKNLTKDLLNELEVVKSR--- 476
+ ++ E+E+L+ + ++ E Q L+ E + K + LNE+E+ S
Sbjct: 1577 IAEKDEEIEQLKRNYQRT-VETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANR 1635
Query: 477 -----VKELECSESRLEKAELSLKDDLTKLKSF--TVMLVDERKNMME-KIKQEERKVDG 528
+K L + +L+ +L L D L + + +V+ R N+++ ++++ ++
Sbjct: 1636 QAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ 1695
Query: 529 LNKNFKVEQGKVMDVTEK---LIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEK 585
+ K+ + +++D E+ L ++ L+ K ++E + L E ++ ++ EEK
Sbjct: 1696 TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEK 1755
Query: 586 S----SELSCSVDLLKKRLD---GIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIER 638
+ ++ + + LKK D +E +++ + + L E +K +I++
Sbjct: 1756 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1815
Query: 639 LKKRLQQLEV-VEGDLMKTEDEYDQL--------EQKFRTEQDKANFLSQQLEEIKHQIA 689
L+ R+++LE +EG+ K + L E +++E+D+ N L Q K Q+
Sbjct: 1816 LETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVK 1875
Query: 690 KNKAIEKGEVVSQEAEL------RHRFRLEEAKSRDLKAEVQALK 728
+ E ++A + + LEEA+ R AE Q K
Sbjct: 1876 VKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNK 1920
Score = 68.6 bits (166), Expect = 4e-11
Identities = 110/451 (24%), Positives = 191/451 (42%), Gaps = 73/451 (16%)
Query: 26 NAGEKSLSE-DAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLL 84
NA E++L + + K++ N +++ + + + KT E E K++K +EL K D+ L
Sbjct: 1487 NAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELE-KSRKQIELEKADIQLAL 1545
Query: 85 SIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRD---AILAQEKSIGE 141
E L+ E I ++ E T+ + E AE ++ + L R+ + + ++
Sbjct: 1546 EEAEAALEHEEAKILRIQLELTQVKS-EIDRKIAEKDEEIEQLKRNYQRTVETMQSALDA 1604
Query: 142 DVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDF- 200
+V + +E RL++K + + QL A + T+ L + + + D DD
Sbjct: 1605 EVRSR--NEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDAL 1662
Query: 201 ----------------TNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLK 244
NLL+ E E L+ LEQ + +ARK E + R +L+ +
Sbjct: 1663 RGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE--RARKLAEQELLDSNERVQLLHTQ 1720
Query: 245 SFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLK-AITSKSKEDRQKLLKLEVDF 303
+ +L+ ++++ + + LQS+ V+D ++ R EEK K AIT + + LK E D
Sbjct: 1721 NTSLIHT-KKKLETDLMQLQSE-VEDASRDARNAEEKAKKAITDAAMMAEE--LKKEQDT 1776
Query: 304 EHKASRFSQEHEEMNAKLANQESHNRQLRLK-----LVGLTQRIEELE-----------E 347
R + E+ L ++ QL LK + L RI ELE E
Sbjct: 1777 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTE 1836
Query: 348 TNKNLQKAEEE-----------------LQELRDKIA--------KGECGNSSLMAEVEN 382
+ K L+K E LQ+L DK+ + E + A +
Sbjct: 1837 SVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTK 1896
Query: 383 LRKRVLEMEGKDEEITKTESQCRELRKKLQE 413
RK E+E +E ESQ +LR K ++
Sbjct: 1897 FRKAQHELEEAEERADIAESQVNKLRAKTRD 1927
Score = 40.0 bits (92), Expect = 0.013
Identities = 38/170 (22%), Positives = 80/170 (47%), Gaps = 14/170 (8%)
Query: 628 KIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQ 687
KIK L E K ++ ++ + KT+DE + E K + ++K L Q+ +++ Q
Sbjct: 836 KIKPLLKSAETEK----EMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQ 891
Query: 688 IA--KNKAIEKGEVVSQ--EAELRHRFRLEEAKSR-----DLKAEVQALKEKIH-ELMNK 737
+ ++ E Q +A+ + +++E R ++ AE+ A K K+ E
Sbjct: 892 VQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 951
Query: 738 EDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALR 787
+ + L++ + +++ ENK KN+ +E+ L + + R +AL+
Sbjct: 952 KKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQ 1001
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 118 bits (295), Expect = 4e-26
Identities = 164/791 (20%), Positives = 332/791 (41%), Gaps = 112/791 (14%)
Query: 29 EKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSL-----ELSKEDLIQL 83
E+ + E+ + + D+ + G + + E +KSL EL+ L++L
Sbjct: 406 EELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL 465
Query: 84 LSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDV 143
E E Q+ + L+T E G+A K+L++ + L+++ I E+
Sbjct: 466 ----EMENQSLTKTVEELRTTVDSVE------GNAS--KILKMEKENQRLSKKVEILEN- 512
Query: 144 YEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNL 203
+ ++EKQ + L + L+ EK E E S+ +
Sbjct: 513 --------EIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN---------SERQIKI 555
Query: 204 LEQERERLKKL---LEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQ 260
LEQE E L + L Q A ++ ++ NK+ E +K S L ++ + I++
Sbjct: 556 LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKK 615
Query: 261 LGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEM--- 317
+ + ++ ++ E E +L + +++ ++K+ L++ E K QE+ E+
Sbjct: 616 ---ELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCE-KIEALEQENSELERE 671
Query: 318 NAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLM 377
N KL + L +L L + +L+E N L++ E L+ K+A+ + N L
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
Query: 378 AEVENLRKRV--------------LEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRL 423
+E E L+K + + +G D E + + KK+Q+ E ++L +
Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 424 EVEKLQKRMSE-------LEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSR 476
E + LQK + E LE+LE+ + E +QL + ++ + K L + E+ +
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 477 VKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVE 536
++E LEK +L ++ K V ++K+ E++ L K ++
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCV-----------RLKELEKENKELVKRATID 900
Query: 537 QGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTR---ERDELIGKLKSEEEKSSEL--SC 591
++ + E L+ E K ++ +++E+ + L + ++ L+ +S ++ +L S
Sbjct: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK 960
Query: 592 SVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEG 651
LKK L+ I+E + R + + ++K + E LK+R + +V+
Sbjct: 961 LESTLKKSLE-IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS 1019
Query: 652 --------------------DLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKN 691
+L+K +D ++E+ T Q + L QL++++ Q N
Sbjct: 1020 SPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ-NNN 1078
Query: 692 KAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVL 751
+ + Q L+ + + ++ L+ E L + LMN+ QL ++
Sbjct: 1079 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL--------LI 1130
Query: 752 QQRFMEEENKN 762
QQ +E EN++
Sbjct: 1131 QQSSLENENES 1141
Score = 117 bits (293), Expect = 7e-26
Identities = 150/623 (24%), Positives = 286/623 (45%), Gaps = 90/623 (14%)
Query: 204 LEQERERL---KKLLEQEKAYQARKEKEN------AKRLNKLRDELVKLKSFALMLVDER 254
LE++ E+L K+ LEQ + R ++EN A+ RDEL L+ A+ VD+
Sbjct: 267 LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVR-VDKL 325
Query: 255 QMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEH 314
+ + + +++ D+ E KA + KED Q LL+ + E +
Sbjct: 326 ESEVSRY---KERLHDI--------EFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS 374
Query: 315 EEMNAKLANQESHNRQLRLKLVGLT-------QRIEELEETNKNLQKAEE---------- 357
+ KL E N QL+ KL + ++IEEL E N L+ A++
Sbjct: 375 D----KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430
Query: 358 -ELQELRDKIAKGECGNSSLMAEVENLRK-RVLEMEGKDEEITKTESQCRELRKKLQEEE 415
EL+++ E SL EV L R+L++E +++ +TKT ELR + E
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT---VEELRTTVDSVE 487
Query: 416 HHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKS 475
++ ++ L++EK +R+S+ ++ E +E Q +L+ +NL+KDL+ E ++
Sbjct: 488 GNASKI-LKMEKENQRLSKKVEILE------NEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 476 RVKELECSESR----LEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNK 531
++ L + R LE+ L ++ L+ + + + R +EK E K+ L++
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK----ENKI--LHE 594
Query: 532 NFKVEQGKVMDVT------EKLIEESKKLLKLKSEMEEKVYNLTRERDEL---------- 575
+ K K+ + +K +E K+ + E+E ++++L +E + L
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKIT 654
Query: 576 IGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLE 635
K+++ E+++SEL LKK LD + + ++ ++ S+L D + EL
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQL-ESLEKENSQL----DEENLELRRN 709
Query: 636 IERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIE 695
+E LK ++ ++ + + E E +QL++ E KA+F + E+ +Q IE
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGL--ELLKASFKKTERLEVSYQ---GLDIE 764
Query: 696 KGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRF 755
+ + + E++ +DL+ E Q L++ + EL +L QL+ + L+Q
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQET 824
Query: 756 MEEENKNKNMGQEVLNLTKELEL 778
+ E K + +E L ++ E+
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEI 847
Score = 114 bits (284), Expect = 7e-25
Identities = 176/815 (21%), Positives = 355/815 (43%), Gaps = 84/815 (10%)
Query: 10 SASDGHISCPKPSIIGNAGEKSLS---EDAKKKKKSNRKEDDVMASGTVKRHLKTSGECE 66
++S C P + + LS DAK K + R+E ++ L E E
Sbjct: 227 ASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQE----LEEKTEQLLDCKQELE 282
Query: 67 RKTKKSLELSKEDLIQLLS------IMEGELQA-REDVIHMLKTEKTKPEVLEA-HYGSA 118
+ + L +E++ LLS + EL A RE + + K E E H
Sbjct: 283 QMEIELKRLQQENM-NLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEF 341
Query: 119 EPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKET--YRRMLEQLLLAEKCH 176
+V + + +L + K++ ED E + D+L E +KE + L + +
Sbjct: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD 401
Query: 177 RRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKE----NAKR 232
R+ + EL E +S D + L E E++ + E +A Q E + R
Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR 461
Query: 233 LNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDL---TQKLREEEEKLKAITSKS 289
L KL E L V+E + ++ + + K+ + Q+L ++ E L+ +
Sbjct: 462 LLKLEMENQSLTK----TVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE 517
Query: 290 KEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETN 349
K+ Q L D + ++ + E + +E+ RQ+++ L Q E L +T
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETL------RENSERQIKI----LEQENEHLNQTV 567
Query: 350 KNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRK 409
+L++ + E R K + E N L ++ ++ ++E + +I K +E +
Sbjct: 568 SSLRQRSQISAEARVKDIEKE--NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE 625
Query: 410 KLQEEEHHSKELRLEVEKLQKRMSEL----EKLEEAFSKSKSECTQLHLNLEKEKNLTKD 465
+ +E E+ L E E LQK+++ L EK+ EA + SE LE+E K
Sbjct: 626 RAEELENELHHLEKENELLQKKITNLKITCEKI-EALEQENSE-------LERENRKLKK 677
Query: 466 LLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVD---ERKNMMEKIKQE 522
L+ + + +++ LE S+L++ L L+ ++ LK ++ + E K + + +Q
Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
Query: 523 ERKVDGLNKNFKVEQGKVMDVTEKLIE-ESKKLLKLKSEMEEKVYNLTRERDELIGKLKS 581
++ ++ L +FK + + ++V+ + ++ E+++L K +K+ L E +L + ++
Sbjct: 738 KKGLELLKASFK--KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQT 795
Query: 582 EEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKK 641
++ EL S KRL+ +E+ + + + E +++++ ++E+ K
Sbjct: 796 LQKNLEELKIS----SKRLEQLEKENKSLEQ------------ETSQLEKDKKQLEKENK 839
Query: 642 RL-QQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVV 700
RL QQ E+ + L + + LE++ +T + + +K +NK + K +
Sbjct: 840 RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATI 899
Query: 701 SQE--AELRHRFRLEEAKSRDLKAEVQALKEKIHEL-MNKE----DQLSQLQVDYSVLQQ 753
+ LR E+ K++ + +++ L ++ ++ +NKE D+ S Y +L+
Sbjct: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLES 959
Query: 754 RFMEEENKNKNMGQE-VLNLTKELELSKRYSRALR 787
+ K+ + +E + L LE S Y++ LR
Sbjct: 960 KLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR 994
Score = 112 bits (279), Expect = 3e-24
Identities = 177/829 (21%), Positives = 353/829 (42%), Gaps = 103/829 (12%)
Query: 30 KSLSEDAKKKKKSNRKEDDVMASGTVKR---------HL-KTSGECERKTKKSLELSKED 79
++LS+D K+K K + + + ++ HL +T ++++ S E +D
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584
Query: 80 LIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYG-----SAEPEKVLRVLHRDAILA 134
+ + I+ ++ + ++ EK + + HY + E E L L ++ L
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL 644
Query: 135 QEKSIGEDV-------YEKPISELDRLEEKQKET---YRRMLEQLLLAEKCH-------- 176
Q+K + E+ SEL+R K K+T ++ + QL EK +
Sbjct: 645 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL 704
Query: 177 --RRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKA-----------YQA 223
RR V L+ K ++ + LE E+E+LKK LE KA YQ
Sbjct: 705 ELRRNVESLKCASMKMAQLQLENKE----LESEKEQLKKGLELLKASFKKTERLEVSYQG 760
Query: 224 --------RKEKENA-KRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQK 274
+K EN+ K++ +L EL L+ M Q ++E+L + S++++ +
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQDLE----MENQTLQKNLEELKISSKRLE----Q 812
Query: 275 LREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLK 334
L +E + L+ TS+ ++D+++L K +A EE N K+ N E N+ L K
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLS-K 871
Query: 335 LVGLTQ----RIEELEETNKNLQKAE----EELQELRDKIAKGECGNSSLMAEVENLRKR 386
+G+ + R++ELE+ NK L K + L LR+ + + + ++E L
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931
Query: 387 VLEMEGKDEEITKTESQCRELRKKLQEEEHHS---KELRLEVEKLQKRMSELEKLEEAFS 443
+ ++ E + E + R KL E + S K L ++ EK+ + LE+
Sbjct: 932 LEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 991
Query: 444 KSKSECTQLHLNLE--KEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKL 501
+ + E + N E K++ + ++ + + E + L +KD L ++
Sbjct: 992 QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1051
Query: 502 KSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEK---LIEESKKLLKLK 558
+ L E++ + ++KQ E + + L Q + + + E+ L ++ KL
Sbjct: 1052 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1111
Query: 559 SEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKG 618
S + + +L + +L+ + S E ++ + + LK D + + ++ R+
Sbjct: 1112 STLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQA 1171
Query: 619 SELTCPEDNKIKELTLEI--ERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANF 676
SE E K TL+ + L+ + LE L+K + + + LE+ + EQ+K
Sbjct: 1172 SEY---ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK--- 1225
Query: 677 LSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMN 736
LE H+ A E ++ + L H + ++ L+ + + LK ++ N
Sbjct: 1226 --MLLENKNHETV---AAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLN---N 1277
Query: 737 KEDQLSQLQVDYSVLQQRFME---EENKNKNMGQEVLNLTKELELSKRY 782
+ + ++L+ ++S L++++ + K N + + L LE R+
Sbjct: 1278 SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1326
Score = 102 bits (253), Expect = 3e-21
Identities = 144/661 (21%), Positives = 285/661 (43%), Gaps = 83/661 (12%)
Query: 243 LKSFAL---MLVDERQMHIE---QLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKL 296
LK+ AL L+DER H E +L + + L + + K E RQ L
Sbjct: 190 LKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHL 249
Query: 297 LKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAE 356
D + K R QE EE +L + + Q+ ++L L Q L ++ +
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 357 EELQELRDKIAKGECGNSSL------MAEVENLRKRVLEMEGKDEEITKTESQ------- 403
+EL LR+K + + S + + ++E + RV E++ ++ + +T++
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEG 369
Query: 404 CRELRKKLQEEEHHSKELR-----------LEVEKLQKRMSELEKLEEAFSKSKSECTQL 452
R KL E E + +L+ ++ +K+++ M E LE A +S E L
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE--SL 427
Query: 453 HLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDER 512
HL E E+ L+E + E + SRL K E+ LTK VD
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME-NQSLTKTVEELRTTVDSV 486
Query: 513 KNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKL---IEESKKLLKLKSEMEEKVYNLT 569
+ KI + E++ L+K ++ + +++ + L SK L+K K+++E+ + L
Sbjct: 487 EGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETL- 545
Query: 570 RERDELIGKLKSEEEKSSELSCSVDLLKK--------RLDGIEEVEREITRGRSRKGSEL 621
RE E ++K E+++ L+ +V L++ R+ IE+ + + S+L
Sbjct: 546 RENSE--RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL 603
Query: 622 TCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRT-----------E 670
+ E K +++ E+E K++ ++ E +E +L E E + L++K E
Sbjct: 604 SKIEFEK-RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 671 QDKANF------LSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAK-------- 716
Q+ + L + L+ K+ + +++EK E L R +E K
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
Query: 717 ----SRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNL 772
+++L++E + LK+ + L + +L+V Y L + +N +++ L
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 773 TKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAV-FIRKSFQEE 831
EL+ + ++ L+ + + ++ ++S ++ ++ E+ET + +K ++E
Sbjct: 783 ESELQDLEMENQTLQ-----KNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE 837
Query: 832 N 832
N
Sbjct: 838 N 838
Score = 79.7 bits (195), Expect = 2e-14
Identities = 123/599 (20%), Positives = 260/599 (43%), Gaps = 92/599 (15%)
Query: 32 LSEDAKKKKKSNRK------------EDDVMASGTVKRHLKTSGE--------CERKTKK 71
L +D K+ +K N++ E++ + G +++ KT + C R K
Sbjct: 827 LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL--K 884
Query: 72 SLELSKEDLIQLLSI-MEGELQAREDVI-HMLKTEKTKPEVLEAHYGSAEPEKVLRVLHR 129
LE ++L++ +I ++ + RED++ LKT++ ++ + + E EK+ L++
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH---ELEKI--GLNK 939
Query: 130 DAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHK 189
+ +L E+S + Y+ LE K + T ++ LE + EK + LE +
Sbjct: 940 ERLLHDEQSTDDSRYKL-------LESKLESTLKKSLE--IKEEK-----IAALEARLEE 985
Query: 190 HTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQA------------RKEKENAKRLNKLR 237
T+Y + +++ E LK+ ++E+ Q+ R+ +E + L K++
Sbjct: 986 STNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK 1045
Query: 238 DELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLL 297
D L++++ L E+Q QL ++L + L+A + L
Sbjct: 1046 DRLIEVERNNATLQAEKQALKTQL-----------KQLETQNNNLQAQILALQRQTVSLQ 1094
Query: 298 KLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEE 357
+ + + ++ E+ +N++ + + N QL ++ LE N+++ K E
Sbjct: 1095 EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ-------SSLENENESVIKERE 1147
Query: 358 ELQELRDKIAKG----ECGNSSLMAEVENLRKR--VLEMEGKDEEITKTESQCR--ELRK 409
+L+ L D + K E + +E E+L + L+ K+ E+ + + R +L K
Sbjct: 1148 DLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLK 1207
Query: 410 KLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNE 469
+ + E K L++E EK+ E + + K E +L+ + T+ L +
Sbjct: 1208 QKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD 1267
Query: 470 LEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGL 529
+ +KS + + ++RLE LK+ +L + L N E + Q L
Sbjct: 1268 HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL----NNQCELLSQ-------L 1316
Query: 530 NKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSE 588
N + E ++D + L+ +++ LL+ E ++ + R+ + + +L+ ++EK E
Sbjct: 1317 KGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEE 1375
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.330
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,161,165
Number of Sequences: 37866
Number of extensions: 2311977
Number of successful extensions: 34010
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 511
Number of HSP's successfully gapped in prelim test: 1579
Number of HSP's that attempted gapping in prelim test: 12010
Number of HSP's gapped (non-prelim): 8853
length of query: 1213
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1099
effective length of database: 13,930,794
effective search space: 15309942606
effective search space used: 15309942606
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.