Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 31442761
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31442761 amiloride-sensitive cation channel 5, intestinal
[Homo sapiens]
(505 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31442761 amiloride-sensitive cation channel 5, intestinal [Ho... 1039 0.0
gi|21536349 amiloride-sensitive cation channel 2, neuronal isofo... 227 2e-59
gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo ... 224 1e-58
gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo ... 224 1e-58
gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo ... 224 1e-58
gi|9998944 amiloride-sensitive cation channel 1, neuronal isofor... 224 1e-58
gi|21536351 amiloride-sensitive cation channel 2, neuronal isofo... 205 9e-53
gi|34452695 amiloride-sensitive cation channel 1, neuronal isofo... 202 6e-52
gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo... 191 1e-48
gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo... 176 6e-44
gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo sapi... 129 5e-30
gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo sapi... 101 2e-21
gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2 ... 98 2e-20
gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3 ... 98 2e-20
gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [H... 98 2e-20
gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2 ... 93 6e-19
gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1... 93 6e-19
gi|4826954 parathyroid hormone 2 receptor precursor [Homo sapiens] 32 1.4
gi|237874249 XK, Kell blood group complex subunit-related, X-lin... 31 3.0
gi|4502499 cholesterol 25-hydroxylase [Homo sapiens] 30 3.9
gi|239755728 PREDICTED: hypothetical protein [Homo sapiens] 30 6.7
gi|239750244 PREDICTED: hypothetical protein [Homo sapiens] 30 6.7
gi|239744544 PREDICTED: hypothetical protein [Homo sapiens] 30 6.7
gi|101943240 general transcription factor IIIC, polypeptide 1, a... 30 6.7
>gi|31442761 amiloride-sensitive cation channel 5, intestinal [Homo
sapiens]
Length = 505
Score = 1039 bits (2687), Expect = 0.0
Identities = 505/505 (100%), Positives = 505/505 (100%)
Query: 1 MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKI 60
MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKI
Sbjct: 1 MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKI 60
Query: 61 RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTD 120
RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTD
Sbjct: 61 RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTD 120
Query: 121 AVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNS 180
AVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNS
Sbjct: 121 AVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNS 180
Query: 181 TLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAF 240
TLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAF
Sbjct: 181 TLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAF 240
Query: 241 TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP 300
TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP
Sbjct: 241 TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP 300
Query: 301 NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEF 360
NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEF
Sbjct: 301 NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEF 360
Query: 361 KDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEI 420
KDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEI
Sbjct: 361 KDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEI 420
Query: 421 NYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLL 480
NYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLL
Sbjct: 421 NYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLL 480
Query: 481 KISEMTQWTPPPQNHLGNKNRIEEC 505
KISEMTQWTPPPQNHLGNKNRIEEC
Sbjct: 481 KISEMTQWTPPPQNHLGNKNRIEEC 505
>gi|21536349 amiloride-sensitive cation channel 2, neuronal isoform
b [Homo sapiens]
Length = 528
Score = 227 bits (578), Expect = 2e-59
Identities = 137/447 (30%), Positives = 225/447 (50%), Gaps = 28/447 (6%)
Query: 41 FAISTSFHGIHNIVQ-NRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
FA S++ HG+ +I R ++R LW + LGS++++ R+ YF + T ++
Sbjct: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEV 80
Query: 100 YVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAA 159
++ FPAVT CNLN F+ V+K ++ +++ + + EI + +
Sbjct: 81 AASQLTFPAVTLCNLNEFRFSQVSK-NDLYHAGELLALLNNRYEIPDTQMADEKQLEILQ 139
Query: 160 SHQNF--------SIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFN 211
NF ++ EF G + + LL C F G+ CS +DF VFT YG C+TFN
Sbjct: 140 DKANFRSFKPKPFNMREFYDRAGHDIRDM-LLSCHFRGEVCSAEDFKVVFTRYGKCYTFN 198
Query: 212 HGETLQAKRKVSV--SGRGLSLLFNVNQEAFTDNPALGFVD-----AGIIFVIHSPKKVP 264
G + + K +G GL ++ ++ Q+ + P G D AGI IHS + P
Sbjct: 199 SGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYL--PVWGETDETSFEAGIKVQIHSQDEPP 256
Query: 265 QFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP---NIKLQNFSSYSTSGCLKECKA 321
D LG G V ++ + ++ PWG C + L F SYS + C +C+
Sbjct: 257 FIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCET 316
Query: 322 QHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIE 381
+++ + C C +PG C ++Y C P LD + KD C + C
Sbjct: 317 RYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKD-----QEYCVCEMPCNLTR 371
Query: 382 YPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSEL 441
Y +S PS+ + KYL+KK N+S +YI EN++ ++I + LNY+ +Q+KA ++ L
Sbjct: 372 YGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGL 431
Query: 442 LADLGGQLGLFCGASLITIIEIIEYLF 468
L D+GGQ+GLF GAS++T++E+ +Y +
Sbjct: 432 LGDIGGQMGLFIGASILTVLELFDYAY 458
>gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo
sapiens]
Length = 531
Score = 224 bits (572), Expect = 1e-58
Identities = 147/470 (31%), Positives = 232/470 (49%), Gaps = 39/470 (8%)
Query: 26 KPLPSPTERKKFDHD---FAISTSFHGIHNIVQNRS-KIRRVLWLVVVLGSVSLVTWQIY 81
KP P E ++ D FA + S HG+ ++ S +RR +W V+ SV+ +Q+
Sbjct: 2 KPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVA 61
Query: 82 IRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHL 141
R+ Y + T+++ + ++ FPAVT CN+N + + + + ++
Sbjct: 62 ERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAE 121
Query: 142 QEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVF 201
+ G A F + + G L++ LLDC F G+PC P++F +F
Sbjct: 122 HAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDM-LLDCRFRGQPCGPENFTTIF 180
Query: 202 TEYGNCFTFNHG----ETLQAKRKVSVSGRGLSLLFNVNQEAFT----DNPALGFVDAGI 253
T G C+TFN G E L R G GL ++ +V QE + DN F + GI
Sbjct: 181 TRMGKCYTFNSGADGAELLTTTR--GGMGNGLDIMLDVQQEEYLPVWRDNEETPF-EVGI 237
Query: 254 IFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGEC-----NPNIKLQNFS 308
IHS ++ P D LGL G V+ +Q + PWG+C NPN + +
Sbjct: 238 RVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSD 297
Query: 309 S-----------YSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDH 357
Y+ GC C+ +++ ++CGC +PG C Q+Y +C P +D
Sbjct: 298 PLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDA 357
Query: 358 IEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVK 417
+ KD C +CP C Y +S PS+ A ++L++KLN+S YI EN++
Sbjct: 358 MLRKDSC-------ACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLA 410
Query: 418 IEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYL 467
++I + LNY+ +Q+KA +SELL D+GGQ+GLF GASL+TI+EI++YL
Sbjct: 411 LDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYL 460
>gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo
sapiens]
Length = 549
Score = 224 bits (572), Expect = 1e-58
Identities = 147/470 (31%), Positives = 232/470 (49%), Gaps = 39/470 (8%)
Query: 26 KPLPSPTERKKFDHD---FAISTSFHGIHNIVQNRS-KIRRVLWLVVVLGSVSLVTWQIY 81
KP P E ++ D FA + S HG+ ++ S +RR +W V+ SV+ +Q+
Sbjct: 2 KPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVA 61
Query: 82 IRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHL 141
R+ Y + T+++ + ++ FPAVT CN+N + + + + ++
Sbjct: 62 ERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAE 121
Query: 142 QEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVF 201
+ G A F + + G L++ LLDC F G+PC P++F +F
Sbjct: 122 HAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDM-LLDCRFRGQPCGPENFTTIF 180
Query: 202 TEYGNCFTFNHG----ETLQAKRKVSVSGRGLSLLFNVNQEAFT----DNPALGFVDAGI 253
T G C+TFN G E L R G GL ++ +V QE + DN F + GI
Sbjct: 181 TRMGKCYTFNSGADGAELLTTTR--GGMGNGLDIMLDVQQEEYLPVWRDNEETPF-EVGI 237
Query: 254 IFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGEC-----NPNIKLQNFS 308
IHS ++ P D LGL G V+ +Q + PWG+C NPN + +
Sbjct: 238 RVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSD 297
Query: 309 S-----------YSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDH 357
Y+ GC C+ +++ ++CGC +PG C Q+Y +C P +D
Sbjct: 298 PLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDA 357
Query: 358 IEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVK 417
+ KD C +CP C Y +S PS+ A ++L++KLN+S YI EN++
Sbjct: 358 MLRKDSC-------ACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLA 410
Query: 418 IEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYL 467
++I + LNY+ +Q+KA +SELL D+GGQ+GLF GASL+TI+EI++YL
Sbjct: 411 LDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYL 460
>gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo
sapiens]
Length = 543
Score = 224 bits (572), Expect = 1e-58
Identities = 147/470 (31%), Positives = 232/470 (49%), Gaps = 39/470 (8%)
Query: 26 KPLPSPTERKKFDHD---FAISTSFHGIHNIVQNRS-KIRRVLWLVVVLGSVSLVTWQIY 81
KP P E ++ D FA + S HG+ ++ S +RR +W V+ SV+ +Q+
Sbjct: 2 KPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVA 61
Query: 82 IRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHL 141
R+ Y + T+++ + ++ FPAVT CN+N + + + + ++
Sbjct: 62 ERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAE 121
Query: 142 QEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVF 201
+ G A F + + G L++ LLDC F G+PC P++F +F
Sbjct: 122 HAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDM-LLDCRFRGQPCGPENFTTIF 180
Query: 202 TEYGNCFTFNHG----ETLQAKRKVSVSGRGLSLLFNVNQEAFT----DNPALGFVDAGI 253
T G C+TFN G E L R G GL ++ +V QE + DN F + GI
Sbjct: 181 TRMGKCYTFNSGADGAELLTTTR--GGMGNGLDIMLDVQQEEYLPVWRDNEETPF-EVGI 237
Query: 254 IFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGEC-----NPNIKLQNFS 308
IHS ++ P D LGL G V+ +Q + PWG+C NPN + +
Sbjct: 238 RVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSD 297
Query: 309 S-----------YSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDH 357
Y+ GC C+ +++ ++CGC +PG C Q+Y +C P +D
Sbjct: 298 PLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDA 357
Query: 358 IEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVK 417
+ KD C +CP C Y +S PS+ A ++L++KLN+S YI EN++
Sbjct: 358 MLRKDSC-------ACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLA 410
Query: 418 IEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYL 467
++I + LNY+ +Q+KA +SELL D+GGQ+GLF GASL+TI+EI++YL
Sbjct: 411 LDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYL 460
>gi|9998944 amiloride-sensitive cation channel 1, neuronal isoform 2
[Homo sapiens]
Length = 512
Score = 224 bits (572), Expect = 1e-58
Identities = 141/446 (31%), Positives = 231/446 (51%), Gaps = 28/446 (6%)
Query: 41 FAISTSFHGIHNI-VQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
FA +++ HGI +I V IRRVLW V +GS+ L+ + R+ YF++ T ++
Sbjct: 20 FANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEV 79
Query: 100 YVEKMEFPAVTFCNLNRFQ-----TDAVAKFGVIFFLWHIVSKVL--HLQEITANSTGSR 152
+ + FPAVT CNLN F+ T+ + G + L + ++ HL + + +
Sbjct: 80 VAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQ 139
Query: 153 EATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNH 212
+A + FS++EF+ G L + +L C+F G+ C +DF VFT+YG C+ FN
Sbjct: 140 KANFKHYKPKQFSMLEFLHRVGHDLKDM-MLYCKFKGQECGHQDFTTVFTKYGKCYMFNS 198
Query: 213 GETLQAKRKVSV----SGRGLSLLFNVNQEAFTDNPALGFVD-----AGIIFVIHSPKKV 263
GE K ++ +G GL ++ ++ Q+ + P G + AG+ IHS +
Sbjct: 199 GE--DGKPLLTTVKGGTGNGLEIMLDIQQDEYL--PIWGETEETTFEAGVKVQIHSQSEP 254
Query: 264 PQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPN-IKLQNFSSYSTSGCLKECKAQ 322
P LG G V ++ + + PWGEC + + L F YS + C +C+ +
Sbjct: 255 PFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETR 314
Query: 323 HIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEY 382
+I + C C +PG C +++ C P L + KD ++ C C Y
Sbjct: 315 YIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKD-----SNYCLCRTPCNLTRY 369
Query: 383 PATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELL 442
+S PS+ + KYL KK N+S KYI EN++ ++I + LNY+ +Q+KA V+ LL
Sbjct: 370 NKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALL 429
Query: 443 ADLGGQLGLFCGASLITIIEIIEYLF 468
D+GGQ+GLF GAS++TI+E+ +Y++
Sbjct: 430 GDIGGQMGLFIGASILTILELFDYIY 455
>gi|21536351 amiloride-sensitive cation channel 2, neuronal isoform
a [Homo sapiens]
Length = 574
Score = 205 bits (521), Expect = 9e-53
Identities = 137/493 (27%), Positives = 225/493 (45%), Gaps = 74/493 (15%)
Query: 41 FAISTSFHGIHNIVQ-NRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
FA S++ HG+ +I R ++R LW + LGS++++ R+ YF + T ++
Sbjct: 21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEV 80
Query: 100 YVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAA 159
++ FPAVT CNLN F+ V+K ++ +++ + + EI + +
Sbjct: 81 AASQLTFPAVTLCNLNEFRFSQVSK-NDLYHAGELLALLNNRYEIPDTQMADEKQLEILQ 139
Query: 160 SHQNF--------SIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFN 211
NF ++ EF G + + LL C F G+ CS +DF VFT YG C+TFN
Sbjct: 140 DKANFRSFKPKPFNMREFYDRAGHDIRDM-LLSCHFRGEVCSAEDFKVVFTRYGKCYTFN 198
Query: 212 HGETLQAKRKVSV--SGRGLSLLFNVNQEAFTDNPALGFVD-----AGIIFVIHSPKKVP 264
G + + K +G GL ++ ++ Q+ + P G D AGI IHS + P
Sbjct: 199 SGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYL--PVWGETDETSFEAGIKVQIHSQDEPP 256
Query: 265 QFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP---NIKLQNFSSYSTSGCLKECKA 321
D LG G V ++ + ++ PWG C + L F SYS + C +C+
Sbjct: 257 FIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCET 316
Query: 322 QHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIE 381
+++ + C C +PG C ++Y C P LD + KD C + C
Sbjct: 317 RYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKD-----QEYCVCEMPCNLTR 371
Query: 382 YPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSEL 441
Y +S PS+ + KYL+KK N+S +YI EN++ ++I + LNY+ +Q+KA ++ L
Sbjct: 372 YGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGL 431
Query: 442 ----------------------------------------------LADLGGQLGLFCGA 455
L D+GGQ+GLF GA
Sbjct: 432 LGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGGQMGLFIGA 491
Query: 456 SLITIIEIIEYLF 468
S++T++E+ +Y +
Sbjct: 492 SILTVLELFDYAY 504
>gi|34452695 amiloride-sensitive cation channel 1, neuronal isoform
1 [Homo sapiens]
Length = 563
Score = 202 bits (514), Expect = 6e-52
Identities = 134/453 (29%), Positives = 222/453 (49%), Gaps = 45/453 (9%)
Query: 48 HGIHNIVQNRSKI-----RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVE 102
HG+ ++ R+ RR LW++ S L+ RLL + ++P+ T + ++
Sbjct: 67 HGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTRVHREWSR 126
Query: 103 KMEFPAVTFCNLNRFQTDAVAKFGVIFFLWH-------------IVSKVLHLQEITANST 149
++ FPAVT CN N + ++K G +++ H +VS++L E
Sbjct: 127 QLPFPAVTVCNNNPLRFPRLSK-GDLYYAGHWLGLLLPNRTARPLVSELLRGDE--PRRQ 183
Query: 150 GSREATDFAA----SHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYG 205
R+ DF H F+ G L + LL C++ G+ C P +F+ VFT+YG
Sbjct: 184 WFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDM-LLSCKYRGELCGPHNFSSVFTKYG 242
Query: 206 NCFTFNHGETLQAKRKVSV----SGRGLSLLFNVNQEAFTDNPALGFVD-----AGIIFV 256
C+ FN GE K ++ +G GL ++ ++ Q+ + P G + AG+
Sbjct: 243 KCYMFNSGE--DGKPLLTTVKGGTGNGLEIMLDIQQDEYL--PIWGETEETTFEAGVKVQ 298
Query: 257 IHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPN-IKLQNFSSYSTSGC 315
IHS + P LG G V ++ + + PWGEC + + L F YS + C
Sbjct: 299 IHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITAC 358
Query: 316 LKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPV 375
+C+ ++I + C C +PG C +++ C P L + KD ++ C
Sbjct: 359 RIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKD-----SNYCLCRT 413
Query: 376 SCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKA 435
C Y +S PS+ + KYL KK N+S KYI EN++ ++I + LNY+ +Q+KA
Sbjct: 414 PCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKA 473
Query: 436 VSVSELLADLGGQLGLFCGASLITIIEIIEYLF 468
V+ LL D+GGQ+GLF GAS++TI+E+ +Y++
Sbjct: 474 YEVAALLGDIGGQMGLFIGASILTILELFDYIY 506
>gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo
sapiens]
Length = 666
Score = 191 bits (485), Expect = 1e-48
Identities = 124/441 (28%), Positives = 206/441 (46%), Gaps = 32/441 (7%)
Query: 41 FAISTSFHGIHNIV-QNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
FA +++ HG+ +RR LW + +L S++ +Q Y T P +++
Sbjct: 172 FASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPA 231
Query: 100 YVEKME-FPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFA 158
+ FPAVT CN+NRF+ A++ + + HL +T R+ A
Sbjct: 232 APAPVAGFPAVTLCNINRFRHSALSD-----------ADIFHLANLTGLPPKDRDGHRAA 280
Query: 159 A-SHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQ 217
+ +V+ + G L + L C F G CS +F+ V+T YG C+TFN
Sbjct: 281 GLRYPEPDMVDILNRTGHQLADM-LKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSS 339
Query: 218 AKRKVSVSGRGLSLLFNVNQEAFT----DNPALGFVDAGIIFVIHSPKKVPQFDGLGLLS 273
+ G GL ++ ++ QE + + F +AGI IHS ++ P LG
Sbjct: 340 LPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSF-EAGIRVQIHSQEEPPYIHQLGFGV 398
Query: 274 PVGMHARVTIRQVKTVHQEYPWGECNPNIKL-----QNFSSYSTSGCLKECKAQHIKKQC 328
G V+ ++ + + PWG C +L Q +S+YS S C C+ + + ++C
Sbjct: 399 SPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRC 458
Query: 329 GCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSS-CPVSCEEIEYPATIS 387
C +PG C Y C LD + G CP C Y IS
Sbjct: 459 HCRMVHMPGNETICPPNIYIECADHTLDSLGG------GPEGPCFCPTPCNLTRYGKEIS 512
Query: 388 YSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGG 447
P++ + +YL++K N++ YIREN + +++ + L + +Q+ A +S LL DLGG
Sbjct: 513 MVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGG 572
Query: 448 QLGLFCGASLITIIEIIEYLF 468
Q+GLF GAS++T++EI++Y++
Sbjct: 573 QMGLFIGASILTLLEILDYIY 593
>gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo
sapiens]
Length = 647
Score = 176 bits (445), Expect = 6e-44
Identities = 121/443 (27%), Positives = 202/443 (45%), Gaps = 55/443 (12%)
Query: 41 FAISTSFHGIHNIV-QNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
FA +++ HG+ +RR LW + +L S++ +Q Y T P +++
Sbjct: 172 FASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPA 231
Query: 100 YVEKME-FPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFA 158
+ FPAVT CN+NRF+ A++ + + HL +T R+ A
Sbjct: 232 APAPVAGFPAVTLCNINRFRHSALSD-----------ADIFHLANLTGLPPKDRDGHRAA 280
Query: 159 A-SHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQ 217
+ +V+ + G L + L C F G CS +F+ V+T YG C+TFN
Sbjct: 281 GLRYPEPDMVDILNRTGHQLADM-LKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSS 339
Query: 218 AKRKVSVSGRGLSLLFNVNQEAF----TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLS 273
+ G GL ++ ++ QE + + F +AGI IHS ++ P LG
Sbjct: 340 LPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSF-EAGIRVQIHSQEEPPYIHQLGFGV 398
Query: 274 PVGMHARVTIRQVKTVHQEYPWGECNPNI-----KLQNFSSYSTSGCLKECKAQHIKKQC 328
G V+ ++ + + PWG C +LQ +S+YS S C C+ + + ++C
Sbjct: 399 SPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRC 458
Query: 329 GCVPFLLP---GYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPAT 385
C +P G G E P CP C Y
Sbjct: 459 HCRMVHMPDSLGGGPE----------GPCF-----------------CPTPCNLTRYGKE 491
Query: 386 ISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADL 445
IS P++ + +YL++K N++ YIREN + +++ + L + +Q+ A +S LL DL
Sbjct: 492 ISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDL 551
Query: 446 GGQLGLFCGASLITIIEIIEYLF 468
GGQ+GLF GAS++T++EI++Y++
Sbjct: 552 GGQMGLFIGASILTLLEILDYIY 574
>gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo
sapiens]
Length = 640
Score = 129 bits (325), Expect = 5e-30
Identities = 89/330 (26%), Positives = 153/330 (46%), Gaps = 30/330 (9%)
Query: 176 YLNNSTLLDCEFFGKPCSPKDFAHVF-TEYGNCFTFNHGETLQAKRKVSVSGR-GLSLLF 233
Y +L C F +PC+ ++F +F YGNC+ FN G T +A + GL L+
Sbjct: 240 YPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLIL 299
Query: 234 NVNQEAFTDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEY 293
++ QE + P L AG+ ++H + P G+ + G + + K
Sbjct: 300 DIGQEDYV--PFLAST-AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGE 356
Query: 294 PWGECNPN---IKLQNFSS-----YSTSGCLKECKAQHIKKQCGCVPFLLP-----GYGI 340
P+ C N + +QNF S YS CL+ C H+ + C C +L P Y
Sbjct: 357 PYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCN 416
Query: 341 ECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYL 400
D + C S + + ++ C C SC + +Y TIS + +PS+ + ++
Sbjct: 417 NRDFPDWAHCYSDLQMSVAQRETCI-----GMCKESCNDTQYKMTISMADWPSEASEDWI 471
Query: 401 SKKLNQSRKYI------RENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCG 454
L+Q R R+ +VK+ I + + NY+ ++ A ++ LL++LGGQ G + G
Sbjct: 472 FHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMG 531
Query: 455 ASLITIIEIIEYLFTNFYWICIFFLLKISE 484
S++ +IE E + +F WI I L+ +++
Sbjct: 532 GSVLCLIEFGE-IIIDFVWITIIKLVALAK 560
Score = 49.3 bits (116), Expect = 8e-06
Identities = 25/75 (33%), Positives = 43/75 (57%), Gaps = 2/75 (2%)
Query: 44 STSFHGIHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEK 103
+T+ HG I+ K ++ +W ++ L +LV WQ I + Y +W + S+ V + +
Sbjct: 32 NTNTHGPKRIICEGPK-KKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGF-KT 89
Query: 104 MEFPAVTFCNLNRFQ 118
M+FPAVT CN + F+
Sbjct: 90 MDFPAVTICNASPFK 104
>gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo
sapiens]
Length = 649
Score = 101 bits (251), Expect = 2e-21
Identities = 84/318 (26%), Positives = 145/318 (45%), Gaps = 27/318 (8%)
Query: 176 YLNNSTLLDCEFFGKPCSPKDFAHVFTE-YGNCFTFNHGETLQAKRKVSVSGR--GLSLL 232
Y L+ C F G C ++F +GNC+TFN+ E + S+ G GL ++
Sbjct: 251 YSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNREN-ETILSTSMGGSEYGLQVI 309
Query: 233 FNVNQEAFTDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQE 292
+N+E + NP L G +IH + P + +G M + + ++
Sbjct: 310 LYINEEEY--NPFL-VSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLS 366
Query: 293 YPWGECNPN---IKLQNF--SSYSTSGCLKECKAQHIKKQCGCVPFL--LPGYGIECDLQ 345
P+ +C + + ++N ++YS CL C + ++CGC + LP C+ Q
Sbjct: 367 EPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQ 426
Query: 346 KY---FSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSK 402
++ C + ++L S C +C E+ T S + +PS + K+L
Sbjct: 427 QHPNWMYCYYQLHRAFVQEELGC----QSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLP 482
Query: 403 KLNQ------SRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGAS 456
L ++K + +L K+ I Y DLN + + A S+ LL++ GGQLGL+ S
Sbjct: 483 VLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCS 542
Query: 457 LITIIEIIEYLFTNFYWI 474
++ +IEIIE F +F+ I
Sbjct: 543 VVCVIEIIEVFFIDFFSI 560
Score = 67.4 bits (163), Expect = 3e-11
Identities = 37/109 (33%), Positives = 65/109 (59%), Gaps = 6/109 (5%)
Query: 17 EKIKLCLSKK-PLPSPTER--KKFDHDFAISTSFHGIHNIVQNRSKIRRVLWLVVVLGSV 73
EKIK + K P+ P K+ + ++T+ HG IV +R ++RR+LW+ L +V
Sbjct: 5 EKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAV 64
Query: 74 SLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAV 122
+L+ WQ + + +++T + SI+V + K++FPAVT CN+N ++ V
Sbjct: 65 ALILWQCALLVFSFYT--VSVSIKVHF-RKLDFPAVTICNINPYKYSTV 110
>gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2
[Homo sapiens]
Length = 728
Score = 98.2 bits (243), Expect = 2e-20
Identities = 79/324 (24%), Positives = 145/324 (44%), Gaps = 28/324 (8%)
Query: 185 CEFFGKPCSPKDFAHVFTE-YGNCFTFN--HGETLQAKRKVSVSGRGLSLLFNVNQEAFT 241
C F C+ +++H YGNC+TFN + L ++ GLSL+ Q F
Sbjct: 341 CRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINN-GLSLMLRAEQNDFI 399
Query: 242 DNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPN 301
P L V G ++H + D G G+ +++R+ +G+C N
Sbjct: 400 --PLLSTV-TGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKN 456
Query: 302 ---IKLQNF--SSYSTSGCLKECKAQHIKKQCGCVPFLLPG-YGIE-CDLQKYFSCVSPV 354
+ ++N S Y+ C+ C + + K+CGC P +E CD +K+ S
Sbjct: 457 GSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSW---- 512
Query: 355 LDHIEFKDLCTVGTHNSSCPVSCEE----IEYPATISYSSFPSQKALKYLSKKLNQSRKY 410
+ +K + + C C + Y + YS +PS + +++ + L++ Y
Sbjct: 513 -GYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNY 571
Query: 411 I----RENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEY 466
R + K+ I + +LNYK + +V++ LL++LG Q L+ G+S+++++E+ E
Sbjct: 572 TVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAEL 631
Query: 467 LFTNFYWICIFFLLKISEMTQWTP 490
+F + I LL+ W+P
Sbjct: 632 VF-DLLVIMFLMLLRRFRSRYWSP 654
Score = 47.8 bits (112), Expect = 2e-05
Identities = 23/79 (29%), Positives = 44/79 (55%), Gaps = 2/79 (2%)
Query: 41 FAISTSFHG-IHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
F +T+ HG I + ++++ W V+ L + ++ WQ + YF++P + +I +
Sbjct: 121 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLN 180
Query: 100 YVEKMEFPAVTFCNLNRFQ 118
+K+ FPAVT C LN ++
Sbjct: 181 -SDKLVFPAVTICTLNPYR 198
>gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3
[Homo sapiens]
Length = 692
Score = 98.2 bits (243), Expect = 2e-20
Identities = 79/324 (24%), Positives = 145/324 (44%), Gaps = 28/324 (8%)
Query: 185 CEFFGKPCSPKDFAHVFTE-YGNCFTFN--HGETLQAKRKVSVSGRGLSLLFNVNQEAFT 241
C F C+ +++H YGNC+TFN + L ++ GLSL+ Q F
Sbjct: 305 CRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINN-GLSLMLRAEQNDFI 363
Query: 242 DNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPN 301
P L V G ++H + D G G+ +++R+ +G+C N
Sbjct: 364 --PLLSTV-TGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKN 420
Query: 302 ---IKLQNF--SSYSTSGCLKECKAQHIKKQCGCVPFLLPG-YGIE-CDLQKYFSCVSPV 354
+ ++N S Y+ C+ C + + K+CGC P +E CD +K+ S
Sbjct: 421 GSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSW---- 476
Query: 355 LDHIEFKDLCTVGTHNSSCPVSCEE----IEYPATISYSSFPSQKALKYLSKKLNQSRKY 410
+ +K + + C C + Y + YS +PS + +++ + L++ Y
Sbjct: 477 -GYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNY 535
Query: 411 I----RENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEY 466
R + K+ I + +LNYK + +V++ LL++LG Q L+ G+S+++++E+ E
Sbjct: 536 TVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAEL 595
Query: 467 LFTNFYWICIFFLLKISEMTQWTP 490
+F + I LL+ W+P
Sbjct: 596 VF-DLLVIMFLMLLRRFRSRYWSP 618
Score = 47.8 bits (112), Expect = 2e-05
Identities = 23/79 (29%), Positives = 44/79 (55%), Gaps = 2/79 (2%)
Query: 41 FAISTSFHG-IHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
F +T+ HG I + ++++ W V+ L + ++ WQ + YF++P + +I +
Sbjct: 85 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLN 144
Query: 100 YVEKMEFPAVTFCNLNRFQ 118
+K+ FPAVT C LN ++
Sbjct: 145 -SDKLVFPAVTICTLNPYR 162
>gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [Homo
sapiens]
Length = 669
Score = 98.2 bits (243), Expect = 2e-20
Identities = 79/324 (24%), Positives = 145/324 (44%), Gaps = 28/324 (8%)
Query: 185 CEFFGKPCSPKDFAHVFTE-YGNCFTFN--HGETLQAKRKVSVSGRGLSLLFNVNQEAFT 241
C F C+ +++H YGNC+TFN + L ++ GLSL+ Q F
Sbjct: 282 CRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINN-GLSLMLRAEQNDFI 340
Query: 242 DNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPN 301
P L V G ++H + D G G+ +++R+ +G+C N
Sbjct: 341 --PLLSTV-TGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKN 397
Query: 302 ---IKLQNF--SSYSTSGCLKECKAQHIKKQCGCVPFLLPG-YGIE-CDLQKYFSCVSPV 354
+ ++N S Y+ C+ C + + K+CGC P +E CD +K+ S
Sbjct: 398 GSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSW---- 453
Query: 355 LDHIEFKDLCTVGTHNSSCPVSCEE----IEYPATISYSSFPSQKALKYLSKKLNQSRKY 410
+ +K + + C C + Y + YS +PS + +++ + L++ Y
Sbjct: 454 -GYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNY 512
Query: 411 I----RENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEY 466
R + K+ I + +LNYK + +V++ LL++LG Q L+ G+S+++++E+ E
Sbjct: 513 TVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAEL 572
Query: 467 LFTNFYWICIFFLLKISEMTQWTP 490
+F + I LL+ W+P
Sbjct: 573 VF-DLLVIMFLMLLRRFRSRYWSP 595
Score = 47.8 bits (112), Expect = 2e-05
Identities = 23/79 (29%), Positives = 44/79 (55%), Gaps = 2/79 (2%)
Query: 41 FAISTSFHG-IHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
F +T+ HG I + ++++ W V+ L + ++ WQ + YF++P + +I +
Sbjct: 62 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLN 121
Query: 100 YVEKMEFPAVTFCNLNRFQ 118
+K+ FPAVT C LN ++
Sbjct: 122 -SDKLVFPAVTICTLNPYR 139
>gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2
[Homo sapiens]
Length = 638
Score = 92.8 bits (229), Expect = 6e-19
Identities = 78/302 (25%), Positives = 131/302 (43%), Gaps = 27/302 (8%)
Query: 182 LLDCEFFGKPCSPKDFAHVF-TEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAF 240
+L C + G C + F YG+C+T + T Q G+ L+ V Q+
Sbjct: 260 VLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGIT----HGVGLVLRVEQQPH 315
Query: 241 TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP 300
P L + AGI ++H P G A ++IR+ + P+G C
Sbjct: 316 L--PLLSTL-AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTA 372
Query: 301 N-----IKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVL 355
++L + +SY+ CL C Q + + C C +L P + + S P
Sbjct: 373 GGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHP---LPAGAEYCSSARHPAW 429
Query: 356 DHIEFKDLCTVGTHN----SSCPVSCEEIEYPATISYSSFPSQKALKYLSKKL------N 405
H ++ + TH S CP C E + + S +PS K+ + L +
Sbjct: 430 GHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPH 489
Query: 406 QSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIE 465
QS + R +L KI I Y +LNY+ ++ SV +LL+ +G L+ GAS+++++E++E
Sbjct: 490 QSHRQ-RSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLE 548
Query: 466 YL 467
L
Sbjct: 549 LL 550
Score = 33.5 bits (75), Expect = 0.47
Identities = 18/76 (23%), Positives = 40/76 (52%), Gaps = 2/76 (2%)
Query: 41 FAISTSFHGIHNIVQNR-SKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
F + + HG +V +R ++++ W ++ LG++ + WQ+ + ++ P ++ V
Sbjct: 63 FCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSV- 121
Query: 100 YVEKMEFPAVTFCNLN 115
+ E+ P VT C+ N
Sbjct: 122 HSERKLLPLVTLCDGN 137
>gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1
[Homo sapiens]
Length = 704
Score = 92.8 bits (229), Expect = 6e-19
Identities = 78/302 (25%), Positives = 131/302 (43%), Gaps = 27/302 (8%)
Query: 182 LLDCEFFGKPCSPKDFAHVF-TEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAF 240
+L C + G C + F YG+C+T + T Q G+ L+ V Q+
Sbjct: 326 VLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGIT----HGVGLVLRVEQQPH 381
Query: 241 TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP 300
P L + AGI ++H P G A ++IR+ + P+G C
Sbjct: 382 L--PLLSTL-AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTA 438
Query: 301 N-----IKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVL 355
++L + +SY+ CL C Q + + C C +L P + + S P
Sbjct: 439 GGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHP---LPAGAEYCSSARHPAW 495
Query: 356 DHIEFKDLCTVGTHN----SSCPVSCEEIEYPATISYSSFPSQKALKYLSKKL------N 405
H ++ + TH S CP C E + + S +PS K+ + L +
Sbjct: 496 GHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPH 555
Query: 406 QSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIE 465
QS + R +L KI I Y +LNY+ ++ SV +LL+ +G L+ GAS+++++E++E
Sbjct: 556 QSHRQ-RSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLE 614
Query: 466 YL 467
L
Sbjct: 615 LL 616
Score = 33.5 bits (75), Expect = 0.47
Identities = 18/76 (23%), Positives = 40/76 (52%), Gaps = 2/76 (2%)
Query: 41 FAISTSFHGIHNIVQNR-SKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQ 99
F + + HG +V +R ++++ W ++ LG++ + WQ+ + ++ P ++ V
Sbjct: 129 FCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSV- 187
Query: 100 YVEKMEFPAVTFCNLN 115
+ E+ P VT C+ N
Sbjct: 188 HSERKLLPLVTLCDGN 203
>gi|4826954 parathyroid hormone 2 receptor precursor [Homo sapiens]
Length = 550
Score = 32.0 bits (71), Expect = 1.4
Identities = 18/78 (23%), Positives = 34/78 (43%), Gaps = 5/78 (6%)
Query: 399 YLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLI 458
++S L + ++++ +V I +L I Q S+ D +G I
Sbjct: 184 FVSFMLRATSIFVKDRVVHAHIGVKELESLIMQDDPQNSIEATSVDKSQYIGC-----KI 238
Query: 459 TIIEIIEYLFTNFYWICI 476
++ I +L TN+YWI +
Sbjct: 239 AVVMFIYFLATNYYWILV 256
>gi|237874249 XK, Kell blood group complex subunit-related, X-linked
[Homo sapiens]
Length = 449
Score = 30.8 bits (68), Expect = 3.0
Identities = 12/39 (30%), Positives = 24/39 (61%)
Query: 48 HGIHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLN 86
H I + +R+ +R+ + LGSV +T+Q+Y+ L++
Sbjct: 156 HSIRTLAMHRNAYKRMSQIQAFLGSVPQLTYQLYVSLIS 194
>gi|4502499 cholesterol 25-hydroxylase [Homo sapiens]
Length = 272
Score = 30.4 bits (67), Expect = 3.9
Identities = 17/61 (27%), Positives = 29/61 (47%)
Query: 125 FGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNSTLLD 184
F + FF+WH++ + T + + ++ FA + Q S+ E F + N TLL
Sbjct: 135 FDMEFFVWHLLHHKVPWLYRTFHKVHHQNSSSFALATQYMSVWELFSLGFFDMMNVTLLG 194
Query: 185 C 185
C
Sbjct: 195 C 195
>gi|239755728 PREDICTED: hypothetical protein [Homo sapiens]
Length = 162
Score = 29.6 bits (65), Expect = 6.7
Identities = 14/43 (32%), Positives = 26/43 (60%), Gaps = 3/43 (6%)
Query: 53 IVQNRSKIRRVLWLVVVLGSVSLVTWQ---IYIRLLNYFTWPT 92
+V + S I ++ W+ + G+ LV + + +RLL+YF+W T
Sbjct: 97 VVMSPSTIPKLSWMTLARGAKQLVVQEALLMILRLLSYFSWFT 139
>gi|239750244 PREDICTED: hypothetical protein [Homo sapiens]
Length = 162
Score = 29.6 bits (65), Expect = 6.7
Identities = 14/43 (32%), Positives = 26/43 (60%), Gaps = 3/43 (6%)
Query: 53 IVQNRSKIRRVLWLVVVLGSVSLVTWQ---IYIRLLNYFTWPT 92
+V + S I ++ W+ + G+ LV + + +RLL+YF+W T
Sbjct: 97 VVMSPSTIPKLSWMTLARGAKQLVVQEALLMILRLLSYFSWFT 139
>gi|239744544 PREDICTED: hypothetical protein [Homo sapiens]
Length = 162
Score = 29.6 bits (65), Expect = 6.7
Identities = 14/43 (32%), Positives = 26/43 (60%), Gaps = 3/43 (6%)
Query: 53 IVQNRSKIRRVLWLVVVLGSVSLVTWQ---IYIRLLNYFTWPT 92
+V + S I ++ W+ + G+ LV + + +RLL+YF+W T
Sbjct: 97 VVMSPSTIPKLSWMTLARGAKQLVVQEALLMILRLLSYFSWFT 139
>gi|101943240 general transcription factor IIIC, polypeptide 1, alpha
220kDa [Homo sapiens]
Length = 2109
Score = 29.6 bits (65), Expect = 6.7
Identities = 12/29 (41%), Positives = 19/29 (65%)
Query: 1 MEQTEKSKVYAENGLLEKIKLCLSKKPLP 29
+ Q +K AENGL +++ LSK+P+P
Sbjct: 1138 INQAKKENTAAENGLTVRLQTFLSKRPMP 1166
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,396,599
Number of Sequences: 37866
Number of extensions: 847160
Number of successful extensions: 1902
Number of sequences better than 10.0: 24
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1808
Number of HSP's gapped (non-prelim): 38
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.