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Search of human proteins with 31377679
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31377679 transmembrane channel-like 5 isoform c [Homo
sapiens]
(760 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31377679 transmembrane channel-like 5 isoform c [Homo sapiens] 1518 0.0
gi|157426860 transmembrane channel-like 5 isoform a [Homo sapiens] 1327 0.0
gi|157426862 transmembrane channel-like 5 isoform b [Homo sapiens] 1104 0.0
gi|187608784 transmembrane channel-like 6 [Homo sapiens] 403 e-112
gi|187608791 transmembrane channel-like 6 [Homo sapiens] 403 e-112
gi|238550098 transmembrane channel-like 7 isoform a [Homo sapiens] 234 3e-61
gi|238550100 transmembrane channel-like 7 isoform b [Homo sapiens] 228 1e-59
gi|23943900 transmembrane channel-like 8 [Homo sapiens] 197 3e-50
gi|21389589 transmembrane channel-like 4 isoform 2 [Homo sapiens] 182 1e-45
gi|223718080 transmembrane channel-like 4 isoform 1 [Homo sapiens] 182 1e-45
gi|21071070 transmembrane channel-like 1 [Homo sapiens] 138 2e-32
gi|94536852 transmembrane cochlear-expressed protein 2 [Homo sap... 135 1e-31
gi|122937502 transmembrane channel-like 3 [Homo sapiens] 103 5e-22
gi|225543215 antigen identified by monoclonal antibody Ki-67 iso... 32 1.7
gi|103472005 antigen identified by monoclonal antibody Ki-67 iso... 32 1.7
gi|105990532 apolipoprotein B precursor [Homo sapiens] 32 2.9
gi|126362983 ribosomal RNA processing 15 homolog [Homo sapiens] 31 3.7
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 31 4.9
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 31 4.9
gi|154354987 hook homolog 2 isoform 2 [Homo sapiens] 30 8.3
>gi|31377679 transmembrane channel-like 5 isoform c [Homo sapiens]
Length = 760
Score = 1518 bits (3931), Expect = 0.0
Identities = 760/760 (100%), Positives = 760/760 (100%)
Query: 1 MLSDDHVNEIIIQVENVSSGVQSHPSSNQIFQEKVLLDSSINMVLSISDIDVIDSQTVSK 60
MLSDDHVNEIIIQVENVSSGVQSHPSSNQIFQEKVLLDSSINMVLSISDIDVIDSQTVSK
Sbjct: 1 MLSDDHVNEIIIQVENVSSGVQSHPSSNQIFQEKVLLDSSINMVLSISDIDVIDSQTVSK 60
Query: 61 RNDQKGNQVLRFSTSLNESMSQTLHSLECMGIDTPGSSHETVQGQKLIASLIPMTSRDRI 120
RNDQKGNQVLRFSTSLNESMSQTLHSLECMGIDTPGSSHETVQGQKLIASLIPMTSRDRI
Sbjct: 61 RNDQKGNQVLRFSTSLNESMSQTLHSLECMGIDTPGSSHETVQGQKLIASLIPMTSRDRI 120
Query: 121 KAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCIQCLNSISRAYRRSKNSLSEILN 180
KAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCIQCLNSISRAYRRSKNSLSEILN
Sbjct: 121 KAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCIQCLNSISRAYRRSKNSLSEILN 180
Query: 181 SISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQFTVAKKNTLQF 240
SISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQFTVAKKNTLQF
Sbjct: 181 SISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQFTVAKKNTLQF 240
Query: 241 TGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNMQLAYIFTIGACLTTCFFSLLFS 300
TGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNMQLAYIFTIGACLTTCFFSLLFS
Sbjct: 241 TGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNMQLAYIFTIGACLTTCFFSLLFS 300
Query: 301 MAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSK 360
MAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSK
Sbjct: 301 MAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSK 360
Query: 361 LTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLLLPFVVSC 420
LTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLLLPFVVSC
Sbjct: 361 LTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLLLPFVVSC 420
Query: 421 INLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNTVALSGEECWE 480
INLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNTVALSGEECWE
Sbjct: 421 INLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNTVALSGEECWE 480
Query: 481 TLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGMQLITSLGLQEFDIARNVLELIYAQTL 540
TLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGMQLITSLGLQEFDIARNVLELIYAQTL
Sbjct: 481 TLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGMQLITSLGLQEFDIARNVLELIYAQTL 540
Query: 541 VWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFT 600
VWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFT
Sbjct: 541 VWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFT 600
Query: 601 GVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWVVWIYRNLIGSVH 660
GVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWVVWIYRNLIGSVH
Sbjct: 601 GVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWVVWIYRNLIGSVH 660
Query: 661 FFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKLQDMEKKANP 720
FFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKLQDMEKKANP
Sbjct: 661 FFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKLQDMEKKANP 720
Query: 721 SSLVLERREVEQQGFLHLGEHDGSLDLRSRRSVQEGNPRA 760
SSLVLERREVEQQGFLHLGEHDGSLDLRSRRSVQEGNPRA
Sbjct: 721 SSLVLERREVEQQGFLHLGEHDGSLDLRSRRSVQEGNPRA 760
>gi|157426860 transmembrane channel-like 5 isoform a [Homo sapiens]
Length = 1006
Score = 1327 bits (3434), Expect = 0.0
Identities = 659/662 (99%), Positives = 661/662 (99%)
Query: 99 HETVQGQKLIASLIPMTSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCI 158
H++ QGQKLIASLIPMTSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCI
Sbjct: 345 HKSPQGQKLIASLIPMTSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCI 404
Query: 159 QCLNSISRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSF 218
QCLNSISRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSF
Sbjct: 405 QCLNSISRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSF 464
Query: 219 ILNFSFIIIPQFTVAKKNTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNM 278
ILNFSFIIIPQFTVAKKNTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNM
Sbjct: 465 ILNFSFIIIPQFTVAKKNTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNM 524
Query: 279 QLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKL 338
QLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKL
Sbjct: 525 QLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKL 584
Query: 339 KQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYN 398
KQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYN
Sbjct: 585 KQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYN 644
Query: 399 LEFLKTHSNPGAVLLLPFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKIS 458
LEFLKTHSNPGAVLLLPFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKIS
Sbjct: 645 LEFLKTHSNPGAVLLLPFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKIS 704
Query: 459 IIGILCYYWLNTVALSGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGMQLIT 518
IIGILCYYWLNTVALSGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGMQLIT
Sbjct: 705 IIGILCYYWLNTVALSGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGMQLIT 764
Query: 519 SLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPS 578
SLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPS
Sbjct: 765 SLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPS 824
Query: 579 KAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDT 638
KAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDT
Sbjct: 825 KAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDT 884
Query: 639 LSTRPGYLWVVWIYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEG 698
LSTRPGYLWVVWIYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEG
Sbjct: 885 LSTRPGYLWVVWIYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEG 944
Query: 699 KDKMFLIEKLIKLQDMEKKANPSSLVLERREVEQQGFLHLGEHDGSLDLRSRRSVQEGNP 758
KDKMFLIEKLIKLQDMEKKANPSSLVLERREVEQQGFLHLGEHDGSLDLRSRRSVQEGNP
Sbjct: 945 KDKMFLIEKLIKLQDMEKKANPSSLVLERREVEQQGFLHLGEHDGSLDLRSRRSVQEGNP 1004
Query: 759 RA 760
RA
Sbjct: 1005 RA 1006
>gi|157426862 transmembrane channel-like 5 isoform b [Homo sapiens]
Length = 948
Score = 1104 bits (2855), Expect = 0.0
Identities = 573/662 (86%), Positives = 584/662 (88%), Gaps = 58/662 (8%)
Query: 99 HETVQGQKLIASLIPMTSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCI 158
H++ QGQKLIASLIPMTSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCI
Sbjct: 345 HKSPQGQKLIASLIPMTSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCI 404
Query: 159 QCLNSISRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSF 218
QCLNSISRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSF
Sbjct: 405 QCLNSISRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSF 464
Query: 219 ILNFSFIIIPQFTVAKKNTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNM 278
ILNFSFIIIPQFTVAKKNTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNM
Sbjct: 465 ILNFSFIIIPQFTVAKKNTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNM 524
Query: 279 QLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKL 338
QLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKL
Sbjct: 525 QLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKL 584
Query: 339 KQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYN 398
KQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYN
Sbjct: 585 KQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYN 644
Query: 399 LEFLKTHSNPGAVLLLPFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKIS 458
LEFLKTHSNPGAVLLLPFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKIS
Sbjct: 645 LEFLKTHSNPGAVLLLPFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKIS 704
Query: 459 IIGILCYYWLNTVALSGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGMQLIT 518
IIGILCYYWLNTVALSGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGMQLIT
Sbjct: 705 IIGILCYYWLNTVALSGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGMQLIT 764
Query: 519 SLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPS 578
SLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPS
Sbjct: 765 SLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPS 824
Query: 579 KAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDT 638
KAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWR+ I +Y
Sbjct: 825 KAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRI---------------ITYLY----- 864
Query: 639 LSTRPGYLWVVWIYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEG 698
W + R ++I L+ QI K + L+ + I
Sbjct: 865 --------WQITEGRK---------------IMIRLLHEQIINEGKDKMFLIEKLI---- 897
Query: 699 KDKMFLIEKLIKLQDMEKKANPSSLVLERREVEQQGFLHLGEHDGSLDLRSRRSVQEGNP 758
KLQDMEKKANPSSLVLERREVEQQGFLHLGEHDGSLDLRSRRSVQEGNP
Sbjct: 898 -----------KLQDMEKKANPSSLVLERREVEQQGFLHLGEHDGSLDLRSRRSVQEGNP 946
Query: 759 RA 760
RA
Sbjct: 947 RA 948
>gi|187608784 transmembrane channel-like 6 [Homo sapiens]
Length = 805
Score = 403 bits (1036), Expect = e-112
Identities = 235/649 (36%), Positives = 359/649 (55%), Gaps = 23/649 (3%)
Query: 95 PGSSHETVQGQKLIASLIPMTSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSK---QTHRI 151
P + E + L+ L + R +R P ++ EKR+LR+ + K Q
Sbjct: 137 PTALEEEEKQSLLVKELQSLAVAQRDHMLRGMPLSLAEKRSLREKSRTPRGKWRGQPGSG 196
Query: 152 LQLNCCIQCLNSISRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLL 211
+CC + + A +L L ++ W+ LK IGG+FG+SVLSYF FL+ LL
Sbjct: 197 GVCSCCGRLRYACVLALHSLGLALLSALQALMPWRYALKRIGGQFGSSVLSYFLFLKTLL 256
Query: 212 KFNIFSFILNFSFIIIPQ--FTVAKKNTLQF-TGLEFFTGVGYFRDTVMYYGFYTNSTIQ 268
FN +L +FI+ PQ F A TGLE TG G F TVMYYG Y+N+T+
Sbjct: 257 AFNALLLLLLVAFIMGPQVAFPPALPGPAPVCTGLELLTGAGCFTHTVMYYGHYSNATLN 316
Query: 269 H-------GNS------GASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIY 315
G+ G YNM LAY+ T+G +L++SMA F ++
Sbjct: 317 QPCGSPLDGSQCTPRVGGLPYNMPLAYLSTVGVSFFITCITLVYSMAHSFGESY-RVGST 375
Query: 316 SGGITKLIFC-WDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYM 374
SG +FC WD+ VT ++A +L+Q N+ T ++E L+E + +S + L + +
Sbjct: 376 SGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKELLAEWQLRHSPRSVCGRLRQAAVLG 435
Query: 375 VAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLLLPFVVSCINLAVPCIYSMFRL 434
+ W++ G A+ C AV+ +E+ ++ + +L+LP VV +NL P + +
Sbjct: 436 LVWLLCLGTALGCAVAVHVFSEFMIQSPEAAGQEAVLLVLPLVVGLLNLGAPYLCRVLAA 495
Query: 435 VERYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNT-VALSGEECWETLIGQDIYRLLLM 493
+E ++ P EVYV + RN+ LK++I+G LCY+WL V + +CWE +GQ++YR L+M
Sbjct: 496 LEPHDSPVLEVYVAICRNLILKLAILGTLCYHWLGRRVGVLQGQCWEDFVGQELYRFLVM 555
Query: 494 DFVFSLVNSFLGEFLRRIIGMQLITSLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPF 553
DFV L+++ GE + RII + + EFDIARNVLELIY QTL W+G+ F PLLP
Sbjct: 556 DFVLMLLDTLFGELVWRIISEKKLKRRRKPEFDIARNVLELIYGQTLTWLGVLFSPLLPA 615
Query: 554 IQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRL 613
+Q+I L ++FY K SL+ N Q P + W AS M T F+ LL FP+F G L +W++
Sbjct: 616 VQIIKLLLVFYVKKTSLLANCQAPRRPWLASHMSTVFLTLLCFPAFLGAAVFLCYAVWQV 675
Query: 614 KPSADCGPFRGLPLFIHSIYSWIDTL-STRPGYLWVVWIYRNLIGSVHFFFILTLIVLII 672
KPS+ CGPFR L + W+ L + P W+ W++R L+ + F F+++ ++L +
Sbjct: 676 KPSSTCGPFRTLDTMYEAGRVWVRHLEAAGPRVSWLPWVHRYLMENTFFVFLVSALLLAV 735
Query: 673 TYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKLQDMEKKANPS 721
YL Q+ G++ +I LL EQI NEG+DK+FLI KL + + +++ S
Sbjct: 736 IYLNIQVVRGQRKVICLLKEQISNEGEDKIFLINKLHSIYERKEREERS 784
>gi|187608791 transmembrane channel-like 6 [Homo sapiens]
Length = 805
Score = 403 bits (1036), Expect = e-112
Identities = 235/649 (36%), Positives = 359/649 (55%), Gaps = 23/649 (3%)
Query: 95 PGSSHETVQGQKLIASLIPMTSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSK---QTHRI 151
P + E + L+ L + R +R P ++ EKR+LR+ + K Q
Sbjct: 137 PTALEEEEKQSLLVKELQSLAVAQRDHMLRGMPLSLAEKRSLREKSRTPRGKWRGQPGSG 196
Query: 152 LQLNCCIQCLNSISRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLL 211
+CC + + A +L L ++ W+ LK IGG+FG+SVLSYF FL+ LL
Sbjct: 197 GVCSCCGRLRYACVLALHSLGLALLSALQALMPWRYALKRIGGQFGSSVLSYFLFLKTLL 256
Query: 212 KFNIFSFILNFSFIIIPQ--FTVAKKNTLQF-TGLEFFTGVGYFRDTVMYYGFYTNSTIQ 268
FN +L +FI+ PQ F A TGLE TG G F TVMYYG Y+N+T+
Sbjct: 257 AFNALLLLLLVAFIMGPQVAFPPALPGPAPVCTGLELLTGAGCFTHTVMYYGHYSNATLN 316
Query: 269 H-------GNS------GASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIY 315
G+ G YNM LAY+ T+G +L++SMA F ++
Sbjct: 317 QPCGSPLDGSQCTPRVGGLPYNMPLAYLSTVGVSFFITCITLVYSMAHSFGESY-RVGST 375
Query: 316 SGGITKLIFC-WDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYM 374
SG +FC WD+ VT ++A +L+Q N+ T ++E L+E + +S + L + +
Sbjct: 376 SGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKELLAEWQLRHSPRSVCGRLRQAAVLG 435
Query: 375 VAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLLLPFVVSCINLAVPCIYSMFRL 434
+ W++ G A+ C AV+ +E+ ++ + +L+LP VV +NL P + +
Sbjct: 436 LVWLLCLGTALGCAVAVHVFSEFMIQSPEAAGQEAVLLVLPLVVGLLNLGAPYLCRVLAA 495
Query: 435 VERYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNT-VALSGEECWETLIGQDIYRLLLM 493
+E ++ P EVYV + RN+ LK++I+G LCY+WL V + +CWE +GQ++YR L+M
Sbjct: 496 LEPHDSPVLEVYVAICRNLILKLAILGTLCYHWLGRRVGVLQGQCWEDFVGQELYRFLVM 555
Query: 494 DFVFSLVNSFLGEFLRRIIGMQLITSLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPF 553
DFV L+++ GE + RII + + EFDIARNVLELIY QTL W+G+ F PLLP
Sbjct: 556 DFVLMLLDTLFGELVWRIISEKKLKRRRKPEFDIARNVLELIYGQTLTWLGVLFSPLLPA 615
Query: 554 IQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRL 613
+Q+I L ++FY K SL+ N Q P + W AS M T F+ LL FP+F G L +W++
Sbjct: 616 VQIIKLLLVFYVKKTSLLANCQAPRRPWLASHMSTVFLTLLCFPAFLGAAVFLCYAVWQV 675
Query: 614 KPSADCGPFRGLPLFIHSIYSWIDTL-STRPGYLWVVWIYRNLIGSVHFFFILTLIVLII 672
KPS+ CGPFR L + W+ L + P W+ W++R L+ + F F+++ ++L +
Sbjct: 676 KPSSTCGPFRTLDTMYEAGRVWVRHLEAAGPRVSWLPWVHRYLMENTFFVFLVSALLLAV 735
Query: 673 TYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKLQDMEKKANPS 721
YL Q+ G++ +I LL EQI NEG+DK+FLI KL + + +++ S
Sbjct: 736 IYLNIQVVRGQRKVICLLKEQISNEGEDKIFLINKLHSIYERKEREERS 784
>gi|238550098 transmembrane channel-like 7 isoform a [Homo sapiens]
Length = 723
Score = 234 bits (596), Expect = 3e-61
Identities = 177/647 (27%), Positives = 308/647 (47%), Gaps = 73/647 (11%)
Query: 122 AIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCIQCLNSISRAYRRSKNSLSEILNS 181
++RN + EKR LR I Q ++ L+ Q S++++R E+
Sbjct: 89 SLRNYALNISEKRRLRDI-------QETQMKYLSEWDQWKRYSSKSWKRFLEKAREMTTH 141
Query: 182 ISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFIL-----------------NFSF 224
+ LW++ ++ I GKFGT + SYF+FLR+L+ N+ F++ N SF
Sbjct: 142 LELWREDIRSIEGKFGTGIQSYFSFLRFLVLLNLVIFLIIFMLVLLPVLLTKYKITNSSF 201
Query: 225 IIIPQFTVAKKNTL---QFTGLEFF--------TGVGYFRDTVMYYGFYTNSTIQHGNSG 273
++IP + K+ T+ +GL +F +G G+ +T ++YG YT ++ N
Sbjct: 202 VLIPFKDMDKQCTVYPVSSSGLIYFYSYIIDLLSGTGFLEETSLFYGHYTIDGVKFQNF- 260
Query: 274 ASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFC-WDFTVTH 332
+Y++ LAY+ + A L ++ + F+ N I + IF WDF +T+
Sbjct: 261 -TYDLPLAYLLSTIASLALSLLWIVKRSVEGFKINLIRSEEHFQSYCNKIFAGWDFCITN 319
Query: 333 EKAVKLKQKNLSTEIRENLSE--LRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAA 390
LK +L E+R +L E +RQ+ ++ T + + +S + + V AC A
Sbjct: 320 RSMADLKHSSLRYELRADLEEERMRQKIAERTSEETIRIYSLRLFLNCIVLAVLGACFYA 379
Query: 391 VYYLAEYNLEFLKTHSNPGA------VLLLP-FVVSCINLAVPCIYSMFRLVERYEMPRH 443
+Y ++ E +K + +L LP V++ N P I++ E Y P
Sbjct: 380 IYVATVFSQEHMKKEIDKMVFGENLFILYLPSIVITLANFITPMIFAKIIRYEDYS-PGF 438
Query: 444 EVYVLLIRNIFLKISIIGILCYYWLNTVALSGEE-------------CWETLIGQDIYRL 490
E+ + ++R +F++++ I +L + + + ++ CWET +GQ++Y+L
Sbjct: 439 EIRLTILRCVFMRLATICVLVFTLGSKITSCDDDTCDLCGYNQKLYPCWETQVGQEMYKL 498
Query: 491 LLMDFVFSLVNSFLGEFLRRII-----GMQLITSLGLQEFDIARNVLELIYAQTLVWIGI 545
++ DF+ L + +F R+++ +LI G QEF I NVL ++Y QT+ WIG
Sbjct: 499 MIFDFIIILAVTLFVDFPRKLLVTYCSSCKLIQCWGQQEFAIPDNVLGIVYGQTICWIGA 558
Query: 546 FFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCT 605
FF PLLP I + I+FY K SL+ +P + +RAS FF+ +L ++
Sbjct: 559 FFSPLLPAIATLKFIIIFYVKEWSLLYTCRPSPRPFRASNSNFFFLLVLLIGLCLAII-P 617
Query: 606 LAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWVVWIYRNLIGSVHFFFIL 665
L I+I R+ S CGPF I T+ST P L + + + S F
Sbjct: 618 LTISISRIPSSKACGPFTNFNTTWEVIPK---TVSTFPSSL---QSFIHGVTSEAFAVPF 671
Query: 666 TLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKLQ 712
+I+ +I + + + K ++ L EQ+ E +DK +LI+KL + Q
Sbjct: 672 FMIICLIMFYFIALAGAHKRVVIQLREQLSLESRDKCYLIQKLTEAQ 718
>gi|238550100 transmembrane channel-like 7 isoform b [Homo sapiens]
Length = 613
Score = 228 bits (582), Expect = 1e-59
Identities = 166/604 (27%), Positives = 291/604 (48%), Gaps = 66/604 (10%)
Query: 165 SRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFIL---- 220
S++++R E+ + LW++ ++ I GKFGT + SYF+FLR+L+ N+ F++
Sbjct: 15 SKSWKRFLEKAREMTTHLELWREDIRSIEGKFGTGIQSYFSFLRFLVLLNLVIFLIIFML 74
Query: 221 -------------NFSFIIIPQFTVAKKNTL---QFTGLEFF--------TGVGYFRDTV 256
N SF++IP + K+ T+ +GL +F +G G+ +T
Sbjct: 75 VLLPVLLTKYKITNSSFVLIPFKDMDKQCTVYPVSSSGLIYFYSYIIDLLSGTGFLEETS 134
Query: 257 MYYGFYTNSTIQHGNSGASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYS 316
++YG YT ++ N +Y++ LAY+ + A L ++ + F+ N I +
Sbjct: 135 LFYGHYTIDGVKFQNF--TYDLPLAYLLSTIASLALSLLWIVKRSVEGFKINLIRSEEHF 192
Query: 317 GGITKLIFC-WDFTVTHEKAVKLKQKNLSTEIRENLSE--LRQENSKLTFNQLLTRFSAY 373
IF WDF +T+ LK +L E+R +L E +RQ+ ++ T + + +S
Sbjct: 193 QSYCNKIFAGWDFCITNRSMADLKHSSLRYELRADLEEERMRQKIAERTSEETIRIYSLR 252
Query: 374 MVAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSNPGA------VLLLP-FVVSCINLAVP 426
+ + V AC A+Y ++ E +K + +L LP V++ N P
Sbjct: 253 LFLNCIVLAVLGACFYAIYVATVFSQEHMKKEIDKMVFGENLFILYLPSIVITLANFITP 312
Query: 427 CIYSMFRLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNTVALSGEE--------- 477
I++ E Y P E+ + ++R +F++++ I +L + + + ++
Sbjct: 313 MIFAKIIRYEDYS-PGFEIRLTILRCVFMRLATICVLVFTLGSKITSCDDDTCDLCGYNQ 371
Query: 478 ----CWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRII-----GMQLITSLGLQEFDIA 528
CWET +GQ++Y+L++ DF+ L + +F R+++ +LI G QEF I
Sbjct: 372 KLYPCWETQVGQEMYKLMIFDFIIILAVTLFVDFPRKLLVTYCSSCKLIQCWGQQEFAIP 431
Query: 529 RNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMT 588
NVL ++Y QT+ WIG FF PLLP I + I+FY K SL+ +P + +RAS
Sbjct: 432 DNVLGIVYGQTICWIGAFFSPLLPAIATLKFIIIFYVKEWSLLYTCRPSPRPFRASNSNF 491
Query: 589 FFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWV 648
FF+ +L ++ L I+I R+ S CGPF I T+ST P L
Sbjct: 492 FFLLVLLIGLCLAII-PLTISISRIPSSKACGPFTNFNTTWEVIPK---TVSTFPSSL-- 545
Query: 649 VWIYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKL 708
+ + + S F +I+ +I + + + K ++ L EQ+ E +DK +LI+KL
Sbjct: 546 -QSFIHGVTSEAFAVPFFMIICLIMFYFIALAGAHKRVVIQLREQLSLESRDKCYLIQKL 604
Query: 709 IKLQ 712
+ Q
Sbjct: 605 TEAQ 608
>gi|23943900 transmembrane channel-like 8 [Homo sapiens]
Length = 726
Score = 197 bits (501), Expect = 3e-50
Identities = 153/591 (25%), Positives = 274/591 (46%), Gaps = 64/591 (10%)
Query: 169 RRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIP 228
RR + + + + LW+ L IGG FGT + SYF FLR+LL N+ S +L SF+++P
Sbjct: 75 RRLREAAQRLARGLGLWEGALYEIGGLFGTGIRSYFTFLRFLLLLNLLSLLLTASFVLLP 134
Query: 229 QFTVAKKN-------TLQFTG--------LEFFTGVGY------FRDTVMYYGFYTNSTI 267
+ + TLQ G L F + + F +T ++YG Y
Sbjct: 135 LVWLRPPDPGPTLNLTLQCPGSRQSPPGVLRFHNQLWHVLTGRAFTNTYLFYGAYRVGP- 193
Query: 268 QHGNSGASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFC-W 326
S + Y+++LAY+ + ACL CF L M K + Y ++ +F W
Sbjct: 194 ---ESSSVYSIRLAYLLSPLACLLLCFCGTLRRMVKGLPQKTLLGQGYQAPLSAKVFSSW 250
Query: 327 DFTVTHEKAVKLKQKNLSTEIRENLSELR--QENSKLTFNQLLTRFSAYMVAWVVSTGVA 384
DF + ++A +K+ +S E + L E R Q + T Q R +Y+ V++ +
Sbjct: 251 DFCIRVQEAATIKKHEISNEFKVELEEGRRFQLMQQQTRAQTACRLLSYLRVNVLNGLLV 310
Query: 385 IACCAAVYYLAEYNLEFLKTHSNPGAVLLL----PFVVSCINLAVPCIYSMFRLVERYEM 440
+ +A+++ +Y+ + + LLL P V++ +N P +++ +E Y
Sbjct: 311 VGAISAIFWATKYSQD----NKEESLFLLLQYLPPGVIALVNFLGPLLFTFLVQLENYP- 365
Query: 441 PRHEVYVLLIRNIFLKISIIGILCYYWLNTVALSGEE---------------CWETLIGQ 485
P EV + LI + LK++ +G+ T+ G + CWE +G+
Sbjct: 366 PNTEVNLTLIWCVVLKLASLGMFSVSLGQTILCIGRDKSSCESYGYNVCDYQCWENSVGE 425
Query: 486 DIYRLLLMDFVFSLVNSFLGEFLRRII----GMQLITSLGLQEFDIARNVLELIYAQTLV 541
++Y+L + +F+ ++ +FL RR++ + L +EF + +NVL+++ QT+
Sbjct: 426 ELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAWLEREEFLVPKNVLDIVAGQTVT 485
Query: 542 WIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTG 601
W+G+F+CPLLP + + LF+ FY K +L+ N + S+ +RAS TFF L+
Sbjct: 486 WMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASS-STFFFQLVLLLGLLL 544
Query: 602 VLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSW-IDTLSTRPGYLWVVWIYRNLIGSVH 660
L + + S DCG LF + W + G + + +GS
Sbjct: 545 AAVPLGYVVSSIHSSWDCG------LFTNYSAPWQVVPELVALGLPPIGQRALHYLGSHA 598
Query: 661 FFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKL 711
F F L +++ ++ + T+ I L +Q++ + ++K L+E L +L
Sbjct: 599 FSFPLLIMLSLVLTVCVSQTQANARAIHRLRKQLVWQVQEKWHLVEDLSRL 649
>gi|21389589 transmembrane channel-like 4 isoform 2 [Homo sapiens]
Length = 706
Score = 182 bits (461), Expect = 1e-45
Identities = 158/601 (26%), Positives = 267/601 (44%), Gaps = 74/601 (12%)
Query: 165 SRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSF 224
+R RRSK E L S+ W TLK IGG+FG SYF+ LR+LL N+ + +L
Sbjct: 119 ARLLRRSKEKTKEGLRSLQPWAWTLKRIGGQFGAGTESYFSLLRFLLLLNVLASVLMACM 178
Query: 225 IIIP--------------------QFTVAKKNTLQFTGLEF--FTGVGYFRDTVMYYGFY 262
++P + + + F F +G GY + ++YGFY
Sbjct: 179 TLLPTWLGGAPPGPPGPDISSPCGSYNPHSQGLVTFATQLFNLLSGEGYLEWSPLFYGFY 238
Query: 263 TNSTIQHGNSGASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKL 322
+Y L + F +G C +L + + +
Sbjct: 239 P----PRPRLAVTY---LCWAFAVGLI---CLLLILHRSVSGLKQTLLAESEALTSYSHR 288
Query: 323 IF-CWDFTVTHEKAVKLKQKNLSTEIRENLSE--LRQENSKLTFNQLLTRFSAYMVAWVV 379
+F WDF + + V+L+Q+ + E++ L E +R++ + T Q + ++ ++
Sbjct: 289 VFSAWDFGLCGDVHVRLRQRIILYELKVELEETVVRRQAAVRTLGQQARVWLVRVLLNLL 348
Query: 380 STGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLL------LPFV-VSCINLAVPCIYSMF 432
+ A VY+ +E + LL LP + ++ +N +P ++ +
Sbjct: 349 VVALLGAAFYGVYWATGCTVELQEMPLVQELPLLKLGVNYLPSIFIAGVNFVLPPVFKLI 408
Query: 433 RLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNTVALSGEE--------------- 477
+E Y R V++LL R +FL+++ + +L + N + G+
Sbjct: 409 APLEGYTRSRQIVFILL-RTVFLRLASLVVLLFSLWNQITCGGDSEAEDCKTCGYNYKQL 467
Query: 478 -CWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRII-GM---QLITSLGLQEFDIARNVL 532
CWET++GQ++Y+LLL D + L + L +F R+++ G+ L G QEF + VL
Sbjct: 468 PCWETVLGQEMYKLLLFDLLTVLAVALLIQFPRKLLCGLCPGALGRLAGTQEFQVPDEVL 527
Query: 533 ELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFF-I 591
LIYAQT+VW+G FFCPLLP + + ++FY K ++L P ++ +RAS FF +
Sbjct: 528 GLIYAQTVVWVGSFFCPLLPLLNTVKFLLLFYLKKLTLFSTCSPAARTFRASAANFFFPL 587
Query: 592 FLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTL-STRPGYLWVVW 650
LL + + V L +I+ + PS CGPFRG I I +L T +L+
Sbjct: 588 VLLLGLAISSV--PLLYSIFLIPPSKLCGPFRGQSSIWAQIPESISSLPETTQNFLF--- 642
Query: 651 IYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIK 710
+G+ F L LI I+ + +I L Q E ++K+FL + +
Sbjct: 643 ----FLGTQAFAVPLLLISSILMAYTVALANSYGRLISELKRQRQTEAQNKVFLARRAVA 698
Query: 711 L 711
L
Sbjct: 699 L 699
>gi|223718080 transmembrane channel-like 4 isoform 1 [Homo sapiens]
Length = 712
Score = 182 bits (461), Expect = 1e-45
Identities = 158/601 (26%), Positives = 267/601 (44%), Gaps = 74/601 (12%)
Query: 165 SRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSF 224
+R RRSK E L S+ W TLK IGG+FG SYF+ LR+LL N+ + +L
Sbjct: 125 ARLLRRSKEKTKEGLRSLQPWAWTLKRIGGQFGAGTESYFSLLRFLLLLNVLASVLMACM 184
Query: 225 IIIP--------------------QFTVAKKNTLQFTGLEF--FTGVGYFRDTVMYYGFY 262
++P + + + F F +G GY + ++YGFY
Sbjct: 185 TLLPTWLGGAPPGPPGPDISSPCGSYNPHSQGLVTFATQLFNLLSGEGYLEWSPLFYGFY 244
Query: 263 TNSTIQHGNSGASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKL 322
+Y L + F +G C +L + + +
Sbjct: 245 P----PRPRLAVTY---LCWAFAVGLI---CLLLILHRSVSGLKQTLLAESEALTSYSHR 294
Query: 323 IF-CWDFTVTHEKAVKLKQKNLSTEIRENLSE--LRQENSKLTFNQLLTRFSAYMVAWVV 379
+F WDF + + V+L+Q+ + E++ L E +R++ + T Q + ++ ++
Sbjct: 295 VFSAWDFGLCGDVHVRLRQRIILYELKVELEETVVRRQAAVRTLGQQARVWLVRVLLNLL 354
Query: 380 STGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLL------LPFV-VSCINLAVPCIYSMF 432
+ A VY+ +E + LL LP + ++ +N +P ++ +
Sbjct: 355 VVALLGAAFYGVYWATGCTVELQEMPLVQELPLLKLGVNYLPSIFIAGVNFVLPPVFKLI 414
Query: 433 RLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNTVALSGEE--------------- 477
+E Y R V++LL R +FL+++ + +L + N + G+
Sbjct: 415 APLEGYTRSRQIVFILL-RTVFLRLASLVVLLFSLWNQITCGGDSEAEDCKTCGYNYKQL 473
Query: 478 -CWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRII-GM---QLITSLGLQEFDIARNVL 532
CWET++GQ++Y+LLL D + L + L +F R+++ G+ L G QEF + VL
Sbjct: 474 PCWETVLGQEMYKLLLFDLLTVLAVALLIQFPRKLLCGLCPGALGRLAGTQEFQVPDEVL 533
Query: 533 ELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFF-I 591
LIYAQT+VW+G FFCPLLP + + ++FY K ++L P ++ +RAS FF +
Sbjct: 534 GLIYAQTVVWVGSFFCPLLPLLNTVKFLLLFYLKKLTLFSTCSPAARTFRASAANFFFPL 593
Query: 592 FLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTL-STRPGYLWVVW 650
LL + + V L +I+ + PS CGPFRG I I +L T +L+
Sbjct: 594 VLLLGLAISSV--PLLYSIFLIPPSKLCGPFRGQSSIWAQIPESISSLPETTQNFLF--- 648
Query: 651 IYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIK 710
+G+ F L LI I+ + +I L Q E ++K+FL + +
Sbjct: 649 ----FLGTQAFAVPLLLISSILMAYTVALANSYGRLISELKRQRQTEAQNKVFLARRAVA 704
Query: 711 L 711
L
Sbjct: 705 L 705
>gi|21071070 transmembrane channel-like 1 [Homo sapiens]
Length = 760
Score = 138 bits (347), Expect = 2e-32
Identities = 130/563 (23%), Positives = 242/563 (42%), Gaps = 88/563 (15%)
Query: 185 WQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQFT------------- 231
W+ +K I +FG+SV SYF FLRW+ N+ FIL FS I++P++
Sbjct: 170 WENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWGLPYGSLPRKTV 229
Query: 232 --VAKKNTLQFTGLEFFTGVGYFRDTVMYYGFYTNS-TIQHGNSGASYNMQLAYIFTIGA 288
+ + F L F G+ + +V++YG+Y N TI N + + L+Y
Sbjct: 230 PRAEEASAANFGVLYDFNGLAQY--SVLFYGYYDNKRTIGWMN----FRLPLSYFLVGIM 283
Query: 289 CLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIR 348
C+ F +L +M K ++ K+ WD+ + + + K +++ +
Sbjct: 284 CIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNKFNSITMNFK 343
Query: 349 ENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSNP 408
E ++E ++ +++ N L RF ++ + V + +++ + + EF + +P
Sbjct: 344 EAITE--EKAAQVEENVHLIRFLRFLANFFVFLTLG-GSGYLIFWAVKRSQEFAQ--QDP 398
Query: 409 GAVLL-----LPFVVSCINLAVPCIYSMFRLVERY------EMPRHEVYVLLIRNIFLKI 457
+ + V+S + + P ++ +F +E Y + ++ LL+ N+++ I
Sbjct: 399 DTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFI 458
Query: 458 SIIG------------------------ILCY------------YWLNTVALSGEECWET 481
+ I Y ++++ + CWET
Sbjct: 459 LALMDEINNKIEEEKLVKANITLWEANMIKAYNASFSENSTGPPFFVHPADVPRGPCWET 518
Query: 482 LIGQDIYRLLLMDFVFSLVNSFLGEFLR----RIIGMQLITSL-----GLQEFDIARNVL 532
++GQ+ RL + D + + V +G+FLR R L EFDI+ NVL
Sbjct: 519 MVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVL 578
Query: 533 ELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIF 592
LI+ Q ++W+G FF P LP I ++ L Y + ++M P ++ ++AS+ F++
Sbjct: 579 ALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLG 638
Query: 593 LLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWVVWIY 652
+L F + L + + L PS DCGPF G + ++ I W+ I
Sbjct: 639 MLLLILFLSTMPVLYMIV-SLPPSFDCGPFSGK----NRMFEVIGETLEHDFPSWMAKIL 693
Query: 653 RNLIGSVHFFFILTLIVLIITYL 675
R L ++ ++VL I YL
Sbjct: 694 RQLSNPGLVIAVILVMVLAIYYL 716
>gi|94536852 transmembrane cochlear-expressed protein 2 [Homo
sapiens]
Length = 906
Score = 135 bits (341), Expect = 1e-31
Identities = 146/640 (22%), Positives = 263/640 (41%), Gaps = 112/640 (17%)
Query: 59 SKRNDQKGNQVLRFSTSLNESMSQTLHSLECMGIDTPGSSHETVQGQKLIASLI--PMTS 116
SKR + + L S S ES+S+ + + + +KLIA++ P
Sbjct: 127 SKRQKKPRSSSLASSASGGESLSEE---------ELAQILEQVEEKKKLIATMRSKPWPM 177
Query: 117 RDRIKAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCIQCLNSISRAYRRSKNSLS 176
++ +R +E+ + K K KQ + L +++ + + K
Sbjct: 178 AKKLTELREAQEFVEKYEGA---LGKGKGKQLYAYKML---------MAKKWVKFKRDFD 225
Query: 177 EILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQFTVA--- 233
W+ +K I FG+SV SYF FLRW+ N+ F L F +IIP+ +
Sbjct: 226 NFKTQCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPY 285
Query: 234 ------------KKNTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNMQLA 281
++ + F+ L F G Y + + ++YG+Y N Q Y + +A
Sbjct: 286 GSIPRKTVPRAEEEKAMDFSVLWDFEG--YIKYSALFYGYYNN---QRTIGWLRYRLPMA 340
Query: 282 YIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGIT---KLIFCWDFTVTHEKAVKL 338
Y + ++ SMA + + S T K+ WD+ + + +
Sbjct: 341 YFMVGVSVFGYSLIIVIRSMASNTQGSTGEGE--SDNFTFSFKMFTSWDYLIGNSETADN 398
Query: 339 KQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAA-----VYY 393
K +++T +E++ + ++ N + + LTRF + ++ I CC +Y+
Sbjct: 399 KYASITTSFKESIVDEQESNKEENIH--LTRFLRVLANFL------IICCLCGSGYLIYF 450
Query: 394 LAEYNLEFLKTHSNPGAVLL-LPFVVSCINLAVPCIYSMFRLVERYEMPRH-------EV 445
+ + + +F K + + V+S + + P ++ +E Y PR +
Sbjct: 451 VVKRSQQFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYH-PRTGLKWQLGRI 509
Query: 446 YVLLIRNIFL--------------------KISIIGILCYY----W--------LNTVAL 473
+ L + N++ I+ + YY W L+ +
Sbjct: 510 FALFLGNLYTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPRPPLHPADV 569
Query: 474 SGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRR--IIGMQLITSLGLQ-------E 524
CWET +G + RL + D + + + LG+FLR + M L+ E
Sbjct: 570 PRGSCWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCWCWDLEAGFPSYAE 629
Query: 525 FDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRAS 584
FDI+ NVL LI+ Q ++W+G F+ P L I ++ L Y + ++M + P + ++AS
Sbjct: 630 FDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKAS 689
Query: 585 QMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRG 624
+ F++ LL F +L +A TI L PS DCGPF G
Sbjct: 690 RSNNFYMGLLLLVLFLSLL-PVAYTIMSLPPSFDCGPFSG 728
>gi|122937502 transmembrane channel-like 3 [Homo sapiens]
Length = 1100
Score = 103 bits (258), Expect = 5e-22
Identities = 75/261 (28%), Positives = 127/261 (48%), Gaps = 23/261 (8%)
Query: 476 EECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGMQL-----------ITSLGLQE 524
++CWET +GQ++ +L ++D +F++ + L +F R + L G E
Sbjct: 497 DQCWETYVGQEMLKLSIIDMLFTVASILLIDFFRGLFVRYLSDYWCWDLESKFPEYG--E 554
Query: 525 FDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRAS 584
F IA NVL L+Y Q ++W+G FF P LP ++ L + Y ++ +++ P + +RAS
Sbjct: 555 FKIAENVLHLVYNQGMIWMGAFFSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRAS 614
Query: 585 QMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPG 644
+ F++ +L F F +L T+ I R KPS +CGPF G IY + +
Sbjct: 615 RSNNFYLAMLLFMLFLCMLPTI-FAIVRYKPSLNCGPFSGQ----EKIYDIVSETIEKDF 669
Query: 645 YLWVVWIYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIIN---EGKDK 701
+W + ++ V + L+ ++I YL I K+ L QI N E K K
Sbjct: 670 PVWFGSVVGHISSPVVILPAVLLLFMLIYYLQ-SIARSLKLSNHQLKMQIQNARSEDKKK 728
Query: 702 MF-LIEKLIKLQDMEKKANPS 721
+ ++E I+ Q+ K P+
Sbjct: 729 VAQMVEARIQTQEESTKKLPN 749
Score = 79.7 bits (195), Expect = 9e-15
Identities = 78/310 (25%), Positives = 128/310 (41%), Gaps = 24/310 (7%)
Query: 185 WQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQF------------TV 232
W+ +K I FG+ V SYF FLRWL NI I+ +FI+IP+ T+
Sbjct: 123 WEMRIKKIESHFGSGVASYFIFLRWLFGINIVLTIMTGAFIVIPELIAGQPFGSTARKTI 182
Query: 233 AKKNTLQFTGLEFFTGV-GYFRDTVMYYGFYTNSTIQHGNSGASYNMQLAYIFTIGACLT 291
K+ L+ + GY + +V++YG+Y + A Y + LAY A
Sbjct: 183 PKEQVSSAQDLDTVWSLGGYLQYSVLFYGYYGR---ERKIGRAGYRLPLAYFLVGMAVFA 239
Query: 292 TCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFC-WDFTVTHEKAVKLKQKNLSTEIREN 350
F LL MAK R + + + +FC WD+ + + +A + K + IRE
Sbjct: 240 YSFIILLKKMAKNSRTSLASASNENYTFCWRVFCAWDYLIGNPEAAESKTAAIVNSIREA 299
Query: 351 LSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAE--YNLEFLKTHSNP 408
+ E E K L ++A ++ +Y++ + LE K
Sbjct: 300 ILE---EQEKKKSKNLAVTICLRIIANILVLLSLAGSIYLIYFVVDRSQKLEQSKKELTL 356
Query: 409 GAVLLLPFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWL 468
+ VVS + + P + + +E Y PR + L R + L + + L L
Sbjct: 357 WEKNEVSVVVSLVTMIAPSAFDLIAALEMYH-PRTTLRFQLARVLVLYLGNLYSLIIALL 415
Query: 469 NTV-ALSGEE 477
+ V ++S EE
Sbjct: 416 DKVNSMSIEE 425
>gi|225543215 antigen identified by monoclonal antibody Ki-67 isoform
2 [Homo sapiens]
Length = 2896
Score = 32.3 bits (72), Expect = 1.7
Identities = 34/127 (26%), Positives = 50/127 (39%), Gaps = 21/127 (16%)
Query: 18 SSGVQSHPSSNQIFQEKVLLDSSINMVLSISDIDVIDSQTVSKRNDQKGN---QVLRFST 74
S+G H + +EK D I + + +D+ ++ T SKR Q Q L T
Sbjct: 931 SAGKAMHTPKPSVGEEK---DIIIFVGTPVQKLDLTENLTGSKRRPQTPKEEAQALEDLT 987
Query: 75 SLNESMSQTLHSLECMGIDTPGSSHETVQG---QKLIASLIPMTSRDRIKAIRNQPRTME 131
E TPG + E V K+ P S D + R QP+T
Sbjct: 988 GFKELFQ------------TPGHTEEAVAAGKTTKMPCESSPPESADTPTSTRRQPKTPL 1035
Query: 132 EKRNLRK 138
EKR+++K
Sbjct: 1036 EKRDVQK 1042
>gi|103472005 antigen identified by monoclonal antibody Ki-67 isoform
1 [Homo sapiens]
Length = 3256
Score = 32.3 bits (72), Expect = 1.7
Identities = 34/127 (26%), Positives = 50/127 (39%), Gaps = 21/127 (16%)
Query: 18 SSGVQSHPSSNQIFQEKVLLDSSINMVLSISDIDVIDSQTVSKRNDQKGN---QVLRFST 74
S+G H + +EK D I + + +D+ ++ T SKR Q Q L T
Sbjct: 1291 SAGKAMHTPKPSVGEEK---DIIIFVGTPVQKLDLTENLTGSKRRPQTPKEEAQALEDLT 1347
Query: 75 SLNESMSQTLHSLECMGIDTPGSSHETVQG---QKLIASLIPMTSRDRIKAIRNQPRTME 131
E TPG + E V K+ P S D + R QP+T
Sbjct: 1348 GFKELFQ------------TPGHTEEAVAAGKTTKMPCESSPPESADTPTSTRRQPKTPL 1395
Query: 132 EKRNLRK 138
EKR+++K
Sbjct: 1396 EKRDVQK 1402
>gi|105990532 apolipoprotein B precursor [Homo sapiens]
Length = 4563
Score = 31.6 bits (70), Expect = 2.9
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 1/52 (1%)
Query: 324 FCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMV 375
F W+ V+H K KL I EN ++ +++K+ FN+ L++ YM+
Sbjct: 2129 FNWERQVSHAKE-KLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYMI 2179
>gi|126362983 ribosomal RNA processing 15 homolog [Homo sapiens]
Length = 282
Score = 31.2 bits (69), Expect = 3.7
Identities = 29/151 (19%), Positives = 62/151 (41%), Gaps = 9/151 (5%)
Query: 54 DSQTVSKRNDQKGNQVLRFSTSLNESMSQTLHSLECMGIDTPGSSHETVQGQKLIASLIP 113
D++ K N+ G + + ++M++ L+ TP S + K +
Sbjct: 70 DAEPCDKENENDGESSVGTNMGWADAMAKVLNK------KTPESKPTILVKNKKLEKEKE 123
Query: 114 MTSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQ---LNCCIQCLNSISRAYRR 170
++R++ I+ + + +E + R D + K+T R LQ +Q N++ + +
Sbjct: 124 KLKQERLEKIKQRDKRLEWEMMCRVKPDVVQDKETERNLQRIATRGVVQLFNAVQKHQKN 183
Query: 171 SKNSLSEILNSISLWQKTLKIIGGKFGTSVL 201
+ E +S+ K + + K SVL
Sbjct: 184 VDEKVKEAGSSMRKRAKLISTVSKKDFISVL 214
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 30.8 bits (68), Expect = 4.9
Identities = 16/52 (30%), Positives = 28/52 (53%)
Query: 313 HIYSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSKLTFN 364
H++ GI KL K ++LK + EI++ L E++++N KLT +
Sbjct: 970 HLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTID 1021
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 30.8 bits (68), Expect = 4.9
Identities = 16/52 (30%), Positives = 28/52 (53%)
Query: 313 HIYSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSKLTFN 364
H++ GI KL K ++LK + EI++ L E++++N KLT +
Sbjct: 942 HLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTID 993
>gi|154354987 hook homolog 2 isoform 2 [Homo sapiens]
Length = 717
Score = 30.0 bits (66), Expect = 8.3
Identities = 24/96 (25%), Positives = 46/96 (47%), Gaps = 8/96 (8%)
Query: 107 LIASLIPMTSRDRIKAIRNQPRTMEEKRNLRK-IVDKEKSKQTHRILQLNCCIQCLNSIS 165
L A ++P R+ + ++ +E KR R+ D+E+ ++ R L + + +
Sbjct: 448 LAAEILPAELRETLLRLQ-----LENKRLCRQEAADRERQEELQR--HLEDANRARHGLE 500
Query: 166 RAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVL 201
+R ++ LSE+ + QK L+ GGK S+L
Sbjct: 501 TQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSIL 536
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.327 0.140 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,722,878
Number of Sequences: 37866
Number of extensions: 1044774
Number of successful extensions: 3753
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 3678
Number of HSP's gapped (non-prelim): 30
length of query: 760
length of database: 18,247,518
effective HSP length: 110
effective length of query: 650
effective length of database: 14,082,258
effective search space: 9153467700
effective search space used: 9153467700
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.