Search of human proteins with 30260188

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30260188 Golgi autoantigen, golgin subfamily a, 5 [Homo
sapiens]
         (731 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30260188 Golgi autoantigen, golgin subfamily a, 5 [Homo sapiens]  1407   0.0  
gi|55770834 centromere protein F [Homo sapiens]                       106   7e-23
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         97   5e-20
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]               94   4e-19
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           94   6e-19
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           94   6e-19
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           94   6e-19
gi|21735548 centrosomal protein 2 [Homo sapiens]                       91   3e-18
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    91   3e-18
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]    91   5e-18
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   90   8e-18
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    89   1e-17
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...    89   1e-17
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     88   3e-17
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]    88   3e-17
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]    88   3e-17
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             87   4e-17
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    87   4e-17
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    87   4e-17
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    87   5e-17
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         87   5e-17
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         87   5e-17
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    87   5e-17
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    87   5e-17
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    87   5e-17
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    87   5e-17
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    87   7e-17
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  87   7e-17
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     86   9e-17
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    86   2e-16

>gi|30260188 Golgi autoantigen, golgin subfamily a, 5 [Homo sapiens]
          Length = 731

 Score = 1407 bits (3641), Expect = 0.0
 Identities = 731/731 (100%), Positives = 731/731 (100%)

Query: 1   MSWFVDLAGKAEDLLNRVDQGAATALSRKDNASNIYSKNTDYTELHQQNTDLIYQTGPKS 60
           MSWFVDLAGKAEDLLNRVDQGAATALSRKDNASNIYSKNTDYTELHQQNTDLIYQTGPKS
Sbjct: 1   MSWFVDLAGKAEDLLNRVDQGAATALSRKDNASNIYSKNTDYTELHQQNTDLIYQTGPKS 60

Query: 61  TYISSAADNIRNQKATILAGTANVKVGSRTPVEASHPVENASVPRPSSHFVRRKKSEPDD 120
           TYISSAADNIRNQKATILAGTANVKVGSRTPVEASHPVENASVPRPSSHFVRRKKSEPDD
Sbjct: 61  TYISSAADNIRNQKATILAGTANVKVGSRTPVEASHPVENASVPRPSSHFVRRKKSEPDD 120

Query: 121 ELLFDFLNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQT 180
           ELLFDFLNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQT
Sbjct: 121 ELLFDFLNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQT 180

Query: 181 HEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQS 240
           HEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQS
Sbjct: 181 HEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQS 240

Query: 241 LNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQ 300
           LNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQ
Sbjct: 241 LNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQ 300

Query: 301 LAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADAT 360
           LAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADAT
Sbjct: 301 LAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADAT 360

Query: 361 LKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLN 420
           LKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLN
Sbjct: 361 LKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLN 420

Query: 421 LESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQRE 480
           LESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQRE
Sbjct: 421 LESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQRE 480

Query: 481 EIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQ 540
           EIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQ
Sbjct: 481 EIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQ 540

Query: 541 EFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQ 600
           EFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQ
Sbjct: 541 EFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQ 600

Query: 601 KQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFN 660
           KQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFN
Sbjct: 601 KQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFN 660

Query: 661 DTETNLAGMYGKVRKAASSIDQFSIRLGIFLRRYPIARVFVIIYMALLHLWVMIVLLTYT 720
           DTETNLAGMYGKVRKAASSIDQFSIRLGIFLRRYPIARVFVIIYMALLHLWVMIVLLTYT
Sbjct: 661 DTETNLAGMYGKVRKAASSIDQFSIRLGIFLRRYPIARVFVIIYMALLHLWVMIVLLTYT 720

Query: 721 PEMHHDQPYGK 731
           PEMHHDQPYGK
Sbjct: 721 PEMHHDQPYGK 731


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  106 bits (265), Expect = 7e-23
 Identities = 109/517 (21%), Positives = 221/517 (42%), Gaps = 37/517 (7%)

Query: 138  VEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEES 197
            V +R EK         +   +S ++  +++ K++ E    ++      +  +    Q + 
Sbjct: 2206 VTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQL 2265

Query: 198  SKENVSSNAACPDH----TPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSK 253
             + N +  A C D         + D    E   LR   + LR  +++  ++   +LQ+ K
Sbjct: 2266 KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLK 2325

Query: 254  ETQEELNKARARVE---------KWNADHS-----KSDRMTRGLRAQVDDLTEAVAAKDS 299
            E++   +  + RVE         + N +H+      S      L+A+++ +T+++   + 
Sbjct: 2326 ESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLEL 2385

Query: 300  QLAVL---KVRLQEADQLLSTRTEALEALQSEKSRIMQDQS-------EGNSLQNQALQT 349
             +  +   K  L    Q    R   LE + S    I+Q++        E +S   + LQT
Sbjct: 2386 DVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQT 2445

Query: 350  FQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDE 409
              + L+E  A L  +QE+ K  +   ++++  +E+E+  L + +  A+  Y   +  V+ 
Sbjct: 2446 QLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNG 2505

Query: 410  LQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELE 469
            L Q+V+  K  LE   +E+   K +    +Q +E+L++ L +  G   L      ++EL 
Sbjct: 2506 LIQEVEDGKQKLEKKDEEISRLKNQ----IQDQEQLVSKLSQVEGEHQLWKE--QNLELR 2559

Query: 470  ELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQ 529
             L  E E + + +Q     +      LQ       NE E  +       +++    A + 
Sbjct: 2560 NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKET 2619

Query: 530  ELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELEN 589
            EL+ E+  + Q+   ++E+L   KN L   ++   EEI+  ++QL   TL N   SEL+ 
Sbjct: 2620 ELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLEN---SELKK 2676

Query: 590  RLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQM 626
             L  + +  ++K+  +     E    + + E+  Q +
Sbjct: 2677 SLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL 2713



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 110/494 (22%), Positives = 230/494 (46%), Gaps = 51/494 (10%)

Query: 179  QTHEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEV 238
            +T E  ++    H   ++SS+E++  N A  + +         +ELS +R E   + +E 
Sbjct: 1861 ETSEGLNSDLEMHA--DKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEA 1918

Query: 239  QSLNQEMASLLQRSKETQEELNKARARV-----EKWNADHSKSDRMTRGLRAQVDDLTEA 293
              L  ++  ++Q  K   E+ N+ + +V     E+ +   S+ ++    LR ++D +++ 
Sbjct: 1919 LYLEADL-EVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQ----LRGELDTMSKK 1973

Query: 294  VAAKDSQLAVLKVRLQE--------------ADQLLSTRTEALEALQSEKSRIMQD---- 335
              A D     +K + QE              A+  +  +TE L+ L S+ S +++D    
Sbjct: 1974 TTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHL 2033

Query: 336  QSEGNSLQ--NQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAI 393
            Q +  SL+  +QAL   +  L    A L +E+E   +      ARL++ + E+ N+++A+
Sbjct: 2034 QEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKAL 2093

Query: 394  --TLAER-----KYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLI 446
               L E+     + S  ++ V +L++ ++  ++ +E+ +++ +   +K    L+ +E+  
Sbjct: 2094 EAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEK----LKEREREN 2149

Query: 447  NSLKEGSGFEGLDSSTASSMELEEL-RHEKEMQREEIQKLMGQIHQLRSELQDMEAQQV- 504
            +SLK+    E L+     S E +EL   + E  + E++ L  QI ++   L+  E   V 
Sbjct: 2150 DSLKD--KVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVT 2207

Query: 505  --NEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKD 562
              +E E+  +Q+Q+   Q++         ++ LE  +Q    I+E+       LQ+++K+
Sbjct: 2208 LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKE 2267

Query: 563  RDEEIQKL-RNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLER 621
             +E +  L  +Q   K    S    +E   HQL  ++ + +  LE+   ++  ++ QL+ 
Sbjct: 2268 LNEAVAALCGDQEIMKATEQSLDPPIEEE-HQLRNSIEKLRARLEADEKKQLCVLQQLKE 2326

Query: 622  LEQQMNSASGSSSN 635
             E   +   G   N
Sbjct: 2327 SEHHADLLKGRVEN 2340



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 119/491 (24%), Positives = 215/491 (43%), Gaps = 98/491 (19%)

Query: 221  SHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQE----ELNKARARVEKWNADHSKS 276
            + +L     EN  L+++V++L +E    LQ S+E QE    +   ++A VE       + 
Sbjct: 2139 AEKLKERERENDSLKDKVENLERE----LQMSEENQELVILDAENSKAEVETLKTQIEEM 2194

Query: 277  DRMTR-------GLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEK 329
             R  +        LR++ ++LT+ +  K  QL+       E D+LLS+    LE  +  +
Sbjct: 2195 ARSLKVFELDLVTLRSEKENLTKQIQEKQGQLS-------ELDKLLSSFKSLLEEKEQAE 2247

Query: 330  SRIMQDQSEG-NSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQN 388
             +I ++       LQNQ      + L+EA A L  +QE  K  +      + +    R +
Sbjct: 2248 IQIKEESKTAVEMLQNQL-----KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNS 2302

Query: 389  LAEAITLAERKYSDEKK--------------------RVDELQQQVKLYKLNLESSKQEL 428
            + +   L  R  +DEKK                    RV+ L++++++ + N E +  E 
Sbjct: 2303 IEK---LRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEA 2359

Query: 429  IDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQ 488
             + K +   +    E +  SL+   G E LD  T  S E E L +E + ++E I +L   
Sbjct: 2360 ENSKGEVETLKAKIEGMTQSLR---GLE-LDVVTIRS-EKENLTNELQKEQERISELEII 2414

Query: 489  IHQLRSELQDMEAQQVNEAESA-------REQLQDLHDQIAGQ-------KASKQELETE 534
                 + LQ+ E ++V   E +       + QL++L++++A         KA +Q L ++
Sbjct: 2415 NSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQ 2474

Query: 535  LERLKQEFHYIEEDLYRTKNT---LQS--------------RIKDRDEEIQKLRNQLTNK 577
            +E L+ E   + + L   KN    LQS              +++ +DEEI +L+NQ+ ++
Sbjct: 2475 VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQ 2534

Query: 578  TLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGS 637
                S  S++E   HQL           +  + E  +L  +LE+  Q + S + S  +  
Sbjct: 2535 EQLVSKLSQVEGE-HQL----------WKEQNLELRNLTVELEQKIQVLQSKNASLQDTL 2583

Query: 638  SINMSGIDNGE 648
             +  S   N E
Sbjct: 2584 EVLQSSYKNLE 2594



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 122/548 (22%), Positives = 226/548 (41%), Gaps = 89/548 (16%)

Query: 138  VEIRKEKGKTPVFQSS---QTSSVSSVNPSVTTIKTIEENSFGSQTHEAASNSD-----S 189
            +E    KG+    ++     T S+  +   V TI++ +EN       E    S+     S
Sbjct: 2357 LEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINS 2416

Query: 190  SHEG------QEESSKENVSSNAACPDHTPTPNDDGKSHELSN----LRLENQLLRNEVQ 239
            S E       QE+   +  SS A     T     + +   L N     + + Q L ++V+
Sbjct: 2417 SFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVE 2476

Query: 240  SLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDS 299
             L  E A LLQ   E +      ++ V               GL  +V+D  + +  KD 
Sbjct: 2477 CLELEKAQLLQGLDEAKNNYIVLQSSVN--------------GLIQEVEDGKQKLEKKDE 2522

Query: 300  QLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADA 359
            +++ LK ++Q+ +QL+S  ++     Q  K + ++ ++    L+ Q +Q  Q +      
Sbjct: 2523 EISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELE-QKIQVLQSKNASLQD 2581

Query: 360  TLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKL 419
            TL+  Q SYK +++E    L   +M++ +  E +     K ++ ++ + E+ Q+    + 
Sbjct: 2582 TLEVLQSSYKNLENE----LELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQE 2637

Query: 420  NLESSKQELIDYKQKATR-ILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQ 478
             L   K  L    Q     I  SK++L     E S  +     +   M  +++  E ++ 
Sbjct: 2638 ELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELK----KSLDCMHKDQVEKEGKV- 2692

Query: 479  REEIQKLMGQIHQLRSELQ----DMEAQQVNEAESAREQLQDLHDQIAGQK-------AS 527
            REEI +   ++H+   + Q    D   Q   E ++ RE+L    + ++ QK       +S
Sbjct: 2693 REEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSS 2752

Query: 528  KQELETELERLKQEFHYIEEDLYRTK-------NTLQS-----------------RIKDR 563
            K+EL   L+   Q    I E+L +TK       N L+                  ++++ 
Sbjct: 2753 KEELNNSLKATTQ----ILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEE 2808

Query: 564  DEEIQKLRNQLT-------NKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLV 616
             E +QK  +QL          T+ ++   EL   + +L ETL +K    +    +  SL+
Sbjct: 2809 KEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLL 2868

Query: 617  FQLERLEQ 624
               E+LE+
Sbjct: 2869 ISHEKLEK 2876



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 114/575 (19%), Positives = 240/575 (41%), Gaps = 65/575 (11%)

Query: 114  KKSEPDDELLFDFLNSSQKEPTG---RVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKT 170
            KK E   E L D L+ ++KE       +E++K++ +    + +  S   S N  + T   
Sbjct: 575  KKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQME 634

Query: 171  IEENSFGSQTHEAAS----NSDSSHEGQE-----ESSKENVSSNAACPDHTPTPNDDGKS 221
             E+ +  S+ +   +        SHE  E     E  +EN+S       +      D KS
Sbjct: 635  SEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVL----DSKS 690

Query: 222  HELSNLRLENQLLRNEVQSLNQ----EMASLLQRSKETQEELNKARARVEKWNADHSKSD 277
             E+   +L    L+ + +  +Q    E+ ++  ++ +   ++     +++  + +    D
Sbjct: 691  VEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKD 750

Query: 278  RMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALE-----------ALQ 326
            R  + L A+ + L + + +KD+ L   +    +   L   +  A+            ++ 
Sbjct: 751  RCYQDLHAEYESLRDLLKSKDASLVTNEDH--QRSLLAFDQQPAMHHSFANIIGEQGSMP 808

Query: 327  SEKS--RIMQDQSEGNS--LQNQ--ALQTFQERLHEADATLKREQESYKQMQSEFAARLN 380
            SE+S  R+  DQS  NS  LQN+  +L+   E   + ++ L+++ E   Q++ E    L 
Sbjct: 809  SERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLM 868

Query: 381  KVEMERQN-----------LAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELI 429
            K E   Q+           L E  +  +   ++    ++  +++++L    +E+ + E+ 
Sbjct: 869  KAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQ 928

Query: 430  DYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQI 489
            + K K+  +L+   K +  L E    E  + S+  S+   E+  E   +   ++++   +
Sbjct: 929  ELK-KSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIE-ELTQENGTLKEINASL 986

Query: 490  HQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDL 549
            +Q +  L        N  +   + + +L DQ       KQE    L+R  +E     EDL
Sbjct: 987  NQEKMNLIQKSESFANYIDEREKSISELSDQY------KQEKLILLQRC-EETGNAYEDL 1039

Query: 550  YRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLS 609
             +     Q    +++ +++ L N+ T+  L  + ++ELE       +   +  T L    
Sbjct: 1040 SQKYKAAQ----EKNSKLECLLNECTS--LCENRKNELEQLKEAFAKEHQEFLTKLAFAE 1093

Query: 610  TEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGI 644
                +L+ +LE ++Q + S    + N S     G+
Sbjct: 1094 ERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGL 1128



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 90/467 (19%), Positives = 202/467 (43%), Gaps = 45/467 (9%)

Query: 224 LSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGL 283
           +  ++ EN LL++  +   +E+  L    K  ++ LN+++   E+  A ++  + M R L
Sbjct: 481 MEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDL 540

Query: 284 RAQVDDLTEAVAAKDSQLAVLKVRLQE--ADQLLSTRTEALEALQSEKSRIMQDQSEGNS 341
           + +++    ++  +  +LAV  +  Q   +  LL  R   +E L  + S+          
Sbjct: 541 QEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSK--------TE 592

Query: 342 LQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYS 401
            +++AL +  E   +    LK E+  +   +SE    L ++E E++NL   I   E    
Sbjct: 593 KESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLK 652

Query: 402 DEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSS 461
            ++ +  E  ++V+  +++ E+   E+    +    +L SK   + + K           
Sbjct: 653 TQQIKSHEYNERVRTLEMDRENLSVEI----RNLHNVLDSKSVEVETQKLAY------ME 702

Query: 462 TASSMELEELRHEKEMQRE--EIQKLMGQIHQLRSELQDMEAQQVN------EAESAREQ 513
                E  + +H+KE++    +  +L GQ+  L  +LQ +  + ++      +  +  E 
Sbjct: 703 LQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYES 762

Query: 514 LQDLHDQIAGQKASKQELETELERLKQE--FHYIEEDLYRTKNTLQS-RIKDRDEEIQK- 569
           L+DL         + ++ +  L    Q+   H+   ++   + ++ S R + R E  Q  
Sbjct: 763 LRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSP 822

Query: 570 -----LRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLES--LSTEK--NSLVFQLE 620
                L+N++ +   S  SQ ++ + L +  E L+Q +  +E   +  E+   S V +  
Sbjct: 823 KNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS 882

Query: 621 RLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLA 667
           +   ++   + +  N  +  +S ++N E    + + +L +  ET  A
Sbjct: 883 QRISKLQEDTSAHQNVVAETLSALENKE----KELQLLNDKVETEQA 925



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 106/549 (19%), Positives = 213/549 (38%), Gaps = 59/549 (10%)

Query: 114 KKSEPDDELLFDFLNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEE 173
           KK +   +   D L ++ ++   +VE  K +G     ++ +   +       +  KT ++
Sbjct: 31  KKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE-----SLEKTKQK 85

Query: 174 NSFGSQTHEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQL 233
            S   Q  E+  N     EGQ  S K+ +                    EL   + E + 
Sbjct: 86  ISHELQVKESQVNFQ---EGQLNSGKKQIEK---------------LEQELKRCKSELER 127

Query: 234 LRNEVQSLNQEMASLLQRSKETQEELNKAR----ARVEKWNADHSKSDRMTRGLRAQVDD 289
            +   QS +  +       K     L  ++    ++ E     ++K     + L A+V  
Sbjct: 128 SQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEV-- 185

Query: 290 LTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRI-MQDQSEGNSLQNQALQ 348
             +A+ AK +   + +  +   D      + ++ + Q EK+   +   S+   ++     
Sbjct: 186 --KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSA 243

Query: 349 TF---QERLHEADATL---KREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSD 402
           ++   ++ +  + +TL   KR+  S     S     L++++ + Q L   I   E +   
Sbjct: 244 SYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQG 303

Query: 403 EKKRVDELQQQVKLYKLNLESSKQELID------------------YKQKATRILQSKEK 444
            +K +     + +  +L LE +K ELI+                  Y Q +T+    ++K
Sbjct: 304 HEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQK 363

Query: 445 LINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQV 504
           L    ++ S       S   S+E +    EKE Q EE+ +       L  E   M+A+  
Sbjct: 364 LKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQ-EELSRQQRSFQTLDQECIQMKARLT 422

Query: 505 NEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRD 564
            E + A+     L  ++    + KQ+LE  LE  KQ+    E+  ++     ++ ++   
Sbjct: 423 QELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQ-AFQASQIKENELRRSM 481

Query: 565 EEIQKLRNQLTNKTLSNSSQ-SELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLE 623
           EE++K  N L + +   + +   LE  L  + + L Q Q   E +  +  S    L  L+
Sbjct: 482 EEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQ 541

Query: 624 QQMNSASGS 632
           +++N    S
Sbjct: 542 EKINQQENS 550



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 86/430 (20%), Positives = 166/430 (38%), Gaps = 45/430 (10%)

Query: 23   ATALSRKDNASNIYSK-NTDYTELHQQNTDLIYQTGPKSTYISSAADNIRNQKATILAGT 81
            A  L   D A N Y    +    L Q+  D   +   K   IS   + I++Q+  +++  
Sbjct: 2483 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ-LVSKL 2541

Query: 82   ANVKVGSRTPVEASHPVENASVPRPSSHFVRRKKSEPDDELLFDFLNSSQKEPTGRVEIR 141
            + V+   +   E +  + N +V       V + K+    + L + L SS K     +E+ 
Sbjct: 2542 SQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTL-EVLQSSYKNLENELELT 2600

Query: 142  KEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEESSKEN 201
            K           + S V  VN       T +E     + HE A  +    E QEE S E 
Sbjct: 2601 K---------MDKMSFVEKVNKM-----TAKETELQREMHEMAQKTA---ELQEELSGEK 2643

Query: 202  VSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNK 261
              +  A               +L  L LEN  L+  +  ++++    +++  + +EE+ +
Sbjct: 2644 --NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQ---VEKEGKVREEIAE 2698

Query: 262  ARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEA 321
             + R+ +    H                L +     + ++   + +L   ++ LS++   
Sbjct: 2699 YQLRLHEAEKKHQAL-------------LLDTNKQYEVEIQTYREKLTSKEECLSSQKLE 2745

Query: 322  LEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNK 381
            ++ L+S K  +         +  +  +T  + L   +  LK+E E  +           +
Sbjct: 2746 IDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQ-LKKENERAQGKMKLLIKSCKQ 2804

Query: 382  VEMERQNLAEAITLAERKYSDEKK------RVDELQQQVKLYKLNLESSKQELIDYKQKA 435
            +E E++ L + ++  +     +K       +VDEL  ++K  K  LE   +E  +Y  K 
Sbjct: 2805 LEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKY 2864

Query: 436  TRILQSKEKL 445
              +L S EKL
Sbjct: 2865 CSLLISHEKL 2874



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 70/343 (20%), Positives = 132/343 (38%), Gaps = 27/343 (7%)

Query: 214  TPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKE------TQEELNKARARVE 267
            T N +    E   L+ E   L+ E   + +E+  LLQ +++      T+ E     +   
Sbjct: 1115 TDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPI 1174

Query: 268  KWNADHSKSDRMTRGLRAQVDDLTEAVA--AKDSQLAVLKVRLQEADQLLSTRTEALEAL 325
            + +    +S+R     + Q+D   + ++  + ++QL  L+  L+  +  L    +  E L
Sbjct: 1175 RNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECL 1234

Query: 326  QSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEME 385
            Q E   I  D    N    Q+ +    +  E DA     +E Y     E +   N    +
Sbjct: 1235 QHELQTIRGDLETSNLQDMQSQEISGLKDCEIDA-----EEKYISGPHELSTSQN----D 1285

Query: 386  RQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKL 445
              +L  ++     K ++ +K  + LQ +       L  S+ E I   +K   + +   KL
Sbjct: 1286 NAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRK---MAEEVGKL 1342

Query: 446  INSLKEGSGFEGL-------DSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQD 498
            +N +K  +   GL       D       E    +H   +   +       +     E+Q 
Sbjct: 1343 LNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQM 1402

Query: 499  MEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQE 541
              A+   +  S + + + LHDQ     +   EL+T ++ LK E
Sbjct: 1403 HFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAE 1445



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 33/194 (17%), Positives = 87/194 (44%), Gaps = 16/194 (8%)

Query: 450 KEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAES 509
           KEG     L        +L++L+ EK+ ++ ++  L   + + + ++++    +  E  +
Sbjct: 9   KEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVEN----EKTEGTN 64

Query: 510 AREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQK 569
            + + Q L +     + +KQ++  EL+  + + ++ E  L    N+ + +I+  ++E+++
Sbjct: 65  LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQL----NSGKKQIEKLEQELKR 120

Query: 570 LRNQLTNKTLSNSSQSELENRLH--------QLTETLIQKQTMLESLSTEKNSLVFQLER 621
            +++L     +  S     N  +         LT +     +  E L  + N  V + +R
Sbjct: 121 CKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR 180

Query: 622 LEQQMNSASGSSSN 635
           LE ++ +     ++
Sbjct: 181 LEAEVKALQAKKAS 194


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 147/687 (21%), Positives = 279/687 (40%), Gaps = 87/687 (12%)

Query: 6   DLAGKAEDLLNRVDQGAATALSRKDNASNIYSKNTDYTELHQQNTDLIYQTGPKSTYISS 65
           +L  K E L  R+ +        K   S +  K     +L ++N DL ++    ++++  
Sbjct: 280 ELRDKNESLTMRLHETLKQCQDLKTEKSQMDRK---INQLSEENGDLSFKLREFASHLQQ 336

Query: 66  AADNIRNQKATILAGTAN-VKVGSRTPVEASHPVENASVPRPSSHFVRRKKSEPDDEL-- 122
             D +          T   ++  ++   E S  +++       +  ++ K S+ ++ L  
Sbjct: 337 LQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQ 396

Query: 123 LFDFLNSSQKEPTGRV-EIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTH 181
           L D     + E  G V ++   K +     ++ T   + V    T     E      + H
Sbjct: 397 LQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGH 456

Query: 182 -EAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQS 240
            E      SS     +SS  N+S      +     +    + ++++L  E   L   +Q 
Sbjct: 457 FEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQ 516

Query: 241 LNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQ 300
            +QE+A L Q++KE Q +L +   + E+           ++GLR QV+ L+ ++  K+ Q
Sbjct: 517 QDQELAGLKQQAKEKQAQLAQTLQQQEQ----------ASQGLRHQVEQLSSSLKQKEQQ 566

Query: 301 LAVLK-----VRLQEADQLLSTRTEA-------------LEALQSEKS---RIMQDQSEG 339
           L  +       R   A QL +   E              LEAL+ EK+    I+Q Q + 
Sbjct: 567 LKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQV 626

Query: 340 NSLQNQALQTFQERLHEADATLKRE-------QESYKQMQSEFAARLNKVEMERQNLAEA 392
            +    + QT   +     A L R+        E+ +Q Q E  A++ ++E++ ++  + 
Sbjct: 627 ANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQK 686

Query: 393 ITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLK-- 450
            T  ER   ++    D+LQ+Q++  K +L+ +K  L + K++A   L+ +++ I+ LK  
Sbjct: 687 ATEKERVAQEK----DQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAE 742

Query: 451 -----------------EGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLR 493
                            E +G +GL++      E  +   E E+ R E+ + M   H   
Sbjct: 743 TRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA--ETEVLRRELAEAMAAQHTAE 800

Query: 494 SELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTK 553
           SE +    Q V E  + RE+ +D   + A   A  QE   +L  LK+E     ++L   K
Sbjct: 801 SECE----QLVKEVAAWRERYEDSQQEEAQYGAMFQE---QLMTLKEECEKARQELQEAK 853

Query: 554 NTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKN 613
             +       + +I + +N+L          + L   L Q+ E  ++ Q + + LST + 
Sbjct: 854 EKVAGIESHSELQISRQQNELA------ELHANLARALQQVQEKEVRAQKLADDLSTLQE 907

Query: 614 SLVF---QLERLEQQMNSASGSSSNGS 637
            +     ++ RLE  +  A       S
Sbjct: 908 KMAATSKEVARLETLVRKAGEQQETAS 934



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 99/493 (20%), Positives = 206/493 (41%), Gaps = 79/493 (16%)

Query: 192  EGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEM----AS 247
            E QE +S+E V   A   D  P   ++ +  +  + +   Q +  E + +  E+    A+
Sbjct: 928  EQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAA 987

Query: 248  LLQRSKETQEELNKARARVEKWNADHSKSDR---MTRGLRAQVD---------------D 289
            L++   + QEE  +    V +   +  ++     + +  RA+++                
Sbjct: 988  LMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFAT 1047

Query: 290  LTEAVA-------AKDSQLAVLKVRLQEADQL--LSTRTEALEALQSEKSRIMQDQSEGN 340
            L EA+A        KD +LA  K+R  EA Q+  L    + ++ L+ + ++  ++ + G+
Sbjct: 1048 LQEALAHALTEKEGKDQELA--KLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGS 1105

Query: 341  SLQNQALQTFQE---RLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAE 397
              Q++A    +    +L    A + + ++  ++ Q +  +    +E ER + AE  +  E
Sbjct: 1106 GAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALE 1165

Query: 398  RKYSDEKKRVDEL----------QQQVKLYKLNLESSKQELIDYKQKATRILQSKEK--- 444
                  +++  EL          Q+++  ++  ++   +   ++K +  R  Q  E+   
Sbjct: 1166 TLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNS 1225

Query: 445  LINSLKEGSGFEGLDSSTASSMELEELRHEKEMQR------EEIQKLMGQIHQLRSELQD 498
            LI+SL+E       + S  +   LE+    KE++R      E+ QKL  ++  L++E   
Sbjct: 1226 LISSLEE-------EVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETAS 1278

Query: 499  MEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQS 558
              A+    + + RE++Q L ++   Q+ + + L  EL    +    + ++L         
Sbjct: 1279 NSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQEL--------- 1329

Query: 559  RIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQ 618
              K   E+  +    L+   L ++S   L + L  L    + +Q   E  + EK      
Sbjct: 1330 --KAWQEKFFQKEQALSTLQLEHTSTQALVSEL--LPAKHLCQQLQAEQAAAEKR----H 1381

Query: 619  LERLEQQMNSASG 631
             E LEQ   +A G
Sbjct: 1382 REELEQSKQAAGG 1394



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 82/371 (22%), Positives = 165/371 (44%), Gaps = 45/371 (12%)

Query: 220  KSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADH-SKSDR 278
            K   LS L+LE+        +  Q + S L  +K   ++L   +A  EK + +   +S +
Sbjct: 1339 KEQALSTLQLEH--------TSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQ 1390

Query: 279  MTRGLRAQV----DDLTEAVAAKDSQLAVLKVRLQE--ADQLLSTRTEALEALQSEKSRI 332
               GLRA++     +L E +  +       KV  QE  A QL + +    E L   K   
Sbjct: 1391 AAGGLRAELLRAQRELGELIPLRQ------KVAEQERTAQQLRAEKASYAEQLSMLKKAH 1444

Query: 333  MQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEA 392
                 E   L  +A    Q    E D   ++  +    ++++   RL +V+ E Q+ A  
Sbjct: 1445 GLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARE 1504

Query: 393  ITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEG 452
            + +   KY   K +V E +Q+ +  +  L +  ++L  ++++ T+ ++   K +      
Sbjct: 1505 LEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKL------ 1558

Query: 453  SGFEGLDSSTASSMELEELRHEKEM---QREEIQKLMGQIHQLRSELQDMEAQQVNEAES 509
                  DS  AS ++ ++L+  +      ++E Q+L  Q+++L+++L    +Q+   AE 
Sbjct: 1559 -----ADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQL----SQKEQAAEH 1609

Query: 510  AREQLQDLHDQIAGQKASKQELETE---LERLKQEFHYIEEDLYRTKNTLQS---RIKDR 563
             + Q++        +K   QEL+ +   LE+L++E   +  +  R  + LQ    + K+ 
Sbjct: 1610 YKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEA 1669

Query: 564  DEEIQKLRNQL 574
            ++  + L  Q+
Sbjct: 1670 EQTCRHLTAQV 1680



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 91/454 (20%), Positives = 192/454 (42%), Gaps = 65/454 (14%)

Query: 232  QLLRNEVQSLNQ--------------EMASLLQRSKETQ-------EELNKARARVEKWN 270
            ++L+ ++Q  N+              E A L ++ +E Q       +E ++A+A+V +  
Sbjct: 618  EILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELE 677

Query: 271  AD-HSKSDRMTRGLRA--QVDDLTEAVAAKDSQLAVLKVRLQE----ADQLLSTRTEALE 323
                S+  + T   R   + D L E + A    L V K  L+E    A   L  +   + 
Sbjct: 678  LQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS 737

Query: 324  ALQSE-KSRIMQDQSEGNSLQNQ--ALQTFQERLHEADATLKREQESYKQMQSEFAARLN 380
             L++E +S + Q + E   L+ +    +  + RL +     + E E  ++  +E  A  +
Sbjct: 738  ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQH 797

Query: 381  KVEMERQNLAEAITLAERKYSDEKKRVDE----LQQQVKLYKLNLESSKQELIDYKQKAT 436
              E E + L + +     +Y D ++   +     Q+Q+   K   E ++QEL + K+K  
Sbjct: 798  TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA 857

Query: 437  RILQSKEKLINSLKEGSGFEGLDSSTASSM---------------ELEELRHEKEMQREE 481
             I    E  I+  ++ +    L ++ A ++               +L  L+ +     +E
Sbjct: 858  GIESHSELQIS--RQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKE 915

Query: 482  IQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQ-----KASKQELETELE 536
            + +L   + +   + +    + V E   A ++  +  ++  G+     +A+ Q +E E E
Sbjct: 916  VARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAE 975

Query: 537  RLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQ----LTNKTLSNSSQSELENRL- 591
            ++  E   +   L  ++   Q     ++ E+ +L  +      +  L  ++++ELE RL 
Sbjct: 976  QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035

Query: 592  HQLTETLIQKQTMLESLS---TEKNSLVFQLERL 622
            + L E  ++  T+ E+L+   TEK     +L +L
Sbjct: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQELAKL 1069



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 98/458 (21%), Positives = 187/458 (40%), Gaps = 85/458 (18%)

Query: 181 HEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLE--------NQ 232
           HE   N +   E   + +    + ++  P+    P+   K  E+  L L+        N 
Sbjct: 137 HEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAK-REIRFLELQKVASSSSGNN 195

Query: 233 LLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTE 292
            L     S    M  +LQ  +     L K  A  E+ N D          L  ++ +  +
Sbjct: 196 FLSGSPAS---PMGDILQTPQFQMRRLKKQLAD-ERSNRDE---------LELELAENRK 242

Query: 293 AVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQE 352
            +  KD+Q+A+++ R+      L    +A   L+ ++   ++D++E  ++          
Sbjct: 243 LLTEKDAQIAMMQQRIDRL--ALLNEKQAASPLEPKELEELRDKNESLTM---------- 290

Query: 353 RLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQ 412
           RLHE   TLK+ Q+  K  +S+   ++N++  E  +L+  +          ++    LQQ
Sbjct: 291 RLHE---TLKQCQD-LKTEKSQMDRKINQLSEENGDLSFKL----------REFASHLQQ 336

Query: 413 QVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELR 472
                   L+ +  EL +   KAT+                  E L+       EL    
Sbjct: 337 --------LQDALNELTEEHSKATQ------------------EWLEKQAQLEKELSAAL 370

Query: 473 HEKEMQREEIQKLMGQIHQLR---SELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQ 529
            +K+   E+ + L G++ QL    S+LQD   Q+  E      QL+ L  + A   A+  
Sbjct: 371 QDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNT 430

Query: 530 ELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELEN 589
           +L+  +E L+ E    E  L   +          +EE Q+L + +T+   S S+ S+ + 
Sbjct: 431 QLQARVEMLETERGQQEAKLLAERGHF-------EEEKQQLSSLITDLQSSISNLSQAKE 483

Query: 590 RLHQLTETLIQKQT-MLESLSTEKNSLVFQLERLEQQM 626
            L Q ++    + T  + SL++E  +L   +++ +Q++
Sbjct: 484 ELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQEL 521



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 63/305 (20%), Positives = 132/305 (43%), Gaps = 49/305 (16%)

Query: 221  SHELSNLRLENQLLRNEVQSLNQEM--------ASLLQRSKETQEELNKARARVEKWNAD 272
            + +LS L+  + LL  E + L +            L Q  ++  +EL   RA  E   A+
Sbjct: 1434 AEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAE 1493

Query: 273  HSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRI 332
              +  + T     +++ +T        ++   + R QE  Q L+ + E LE  Q E+++ 
Sbjct: 1494 VQREAQSTA---RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQ 1550

Query: 333  MQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEA 392
            +++ S+  +  +QA +  Q++L    A     Q+  +++Q    A+LN+++ +       
Sbjct: 1551 VEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQ----AQLNELQAQ------- 1599

Query: 393  ITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEG 452
                          + + +Q  + YKL +E +K    D K++  + LQ + + +  L++ 
Sbjct: 1600 --------------LSQKEQAAEHYKLQMEKAKTH-YDAKKQQNQELQEQLRSLEQLQK- 1643

Query: 453  SGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESARE 512
                    +     E E L HE +    + ++       L ++++ +EAQ  +    A +
Sbjct: 1644 -------ENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAH----ADQ 1692

Query: 513  QLQDL 517
            QL+DL
Sbjct: 1693 QLRDL 1697



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 62/317 (19%), Positives = 118/317 (37%), Gaps = 31/317 (9%)

Query: 127  LNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASN 186
            L   Q+    R ++  +  +  VFQ  QT  V  ++  +       +          A  
Sbjct: 1520 LEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQG 1579

Query: 187  SDSSHEGQEESSKEN-----VSSNAACPDHTPTPNDDGKSH----------------ELS 225
             +S  E Q   ++ N     +S      +H     +  K+H                 L 
Sbjct: 1580 GESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE 1639

Query: 226  NLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRA 285
             L+ EN+ LR E + L  E+     ++KE ++      A+V    A  + +D+  R L  
Sbjct: 1640 QLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL-G 1698

Query: 286  QVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQ 345
            +    T+A+ +++ Q    K +L  +   L    E    L S  S++ + Q +G S+  +
Sbjct: 1699 KFQVATDALKSREPQ---AKPQLDLSIDSLDLSCEEGTPL-SITSKLPRTQPDGTSVPGE 1754

Query: 346  ALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKK 405
                  +RL     +L  E   +  + +   A L   E    +L +    + RK    ++
Sbjct: 1755 PASPISQRLPPKVESL--ESLYFTPIPARSQAPL---ESSLDSLGDVFLDSGRKTRSARR 1809

Query: 406  RVDELQQQVKLYKLNLE 422
            R  ++       KL++E
Sbjct: 1810 RTTQIINITMTKKLDVE 1826


>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
          Length = 1946

 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 145/683 (21%), Positives = 267/683 (39%), Gaps = 72/683 (10%)

Query: 44   ELHQQNTDLIYQTGPKSTYISSAADNIR-NQKATILAGTANVKVGSRTPVEAS-HPVE-N 100
            E HQQ  D ++    K + +S A  N++  Q+   L G    +  +R   E   H +E N
Sbjct: 1013 EAHQQTLDDLHMEEEKLSSLSKA--NLKLEQQVDELEGALEQERKARMNCERELHKLEGN 1070

Query: 101  ASVPRPSSHFVRRKKSEPDDELLFDFLNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSS 160
              + R S   +   +    +EL    L  SQ       ++  EKG     Q +       
Sbjct: 1071 LKLNRESMENLESSQRHLAEELRKKELELSQMNS----KVENEKGLVAQLQKT------- 1119

Query: 161  VNPSVTTIKTIEENSFGSQTHEAA---SNSDSSHEGQEESSKENVSSNAACPDHTPTPND 217
            V    T IK ++E     +T  A      +D + +  + + +      ++      T   
Sbjct: 1120 VKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQ 1179

Query: 218  DGKSHELSNLRLENQLLRNEVQS--LNQEMASLLQRSKETQEELNKARARVEKWNADHSK 275
            + K  +L    +E   L  E  S  L +  A  L   +   E L + + ++EK   D S 
Sbjct: 1180 ETKFQKLHR-DMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEK---DKSD 1235

Query: 276  SDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQD 335
                   L  +V+ +T A A  +    + + RL EA   L   T+    L ++K+++  +
Sbjct: 1236 LQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSE 1295

Query: 336  QSEGNSLQNQALQTFQERLHEADAT---LKREQESYKQMQSEFAARLNKVEMERQNLAEA 392
              E           F  RL E +A    L RE+ ++ +   +   +L K    +  LA A
Sbjct: 1296 SGE-----------FLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHA 1344

Query: 393  ITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQK-ATRILQSKEKLINSLKE 451
            +  A+R     +++ +E Q+        L     E++ ++ K    ++Q  E L ++ KE
Sbjct: 1345 LQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKE 1404

Query: 452  -----GSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNE 506
                     E +  + A +  LE  RH+ +++  +    +G++    + L   + Q    
Sbjct: 1405 LAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKA 1464

Query: 507  AESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEE 566
                +++ ++    +   +   Q L TEL +LK  +    E+    + TL+   K+  EE
Sbjct: 1465 LADWKQKHEESQALLDASQKEVQALSTELLKLKNTY----EESIVGQETLRRENKNLQEE 1520

Query: 567  IQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNS---LVFQLERLE 623
            I  L NQ+   T  N ++ E   +L +  +T +Q        + E+N    L FQLE LE
Sbjct: 1521 ISNLTNQVREGT-KNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLE 1579

Query: 624  QQMNSASGSSSNGSSIN-------------MSGIDNGEGTRL------RNVPVLFNDTET 664
             +       S     I               S +D+   +R+      + +    N+ E 
Sbjct: 1580 AKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMEL 1639

Query: 665  NLAGMYGKVRKAASSIDQFSIRL 687
             L+    +V +A  S+ Q  I++
Sbjct: 1640 QLSCANRQVSEATKSLGQLQIQI 1662



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 93/427 (21%), Positives = 188/427 (44%), Gaps = 27/427 (6%)

Query: 225  SNLRLENQL--LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRG 282
            S ++LE ++  L   V+   +  + L  R ++ ++E  + +  ++       KS++  R 
Sbjct: 923  SKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRT 982

Query: 283  LRAQVDDLTEAVAAKDSQLAVLKVR---LQEADQL----LSTRTEALEALQSEKSRIMQ- 334
               +V +LTE V   +  ++ L      +QEA Q     L    E L +L     ++ Q 
Sbjct: 983  TEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQ 1042

Query: 335  -DQSEGNSLQNQALQTFQER-LHEADATLKREQESYKQMQSE---FAARLNKVEMERQNL 389
             D+ EG   Q +  +   ER LH+ +  LK  +ES + ++S     A  L K E+E   +
Sbjct: 1043 VDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQM 1102

Query: 390  AEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSL 449
               +   +   +  +K V ELQ Q+K  K  LE+ +      +++   + Q    L   L
Sbjct: 1103 NSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERL 1162

Query: 450  KEGSGFEGLDSSTASSMELEELRHEK-EMQREEIQKLMGQIHQLRSELQDMEAQQVNEAE 508
            +E  G      S+ + +E+ + +  K +    ++++         + L+   A  + E E
Sbjct: 1163 EEVGG------SSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELE 1216

Query: 509  SAREQLQDLHDQIAGQKASKQ-ELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEI 567
               E LQ +  ++   K+  Q E++  L R++Q     + +  +     + R+ +   ++
Sbjct: 1217 GQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQ-MTRAKANAEKLCTLYEERLHEATAKL 1275

Query: 568  QKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMN 627
             K+  QL N     + +++L +   +    L +K+ ++  LS EK++   Q+E L  Q+ 
Sbjct: 1276 DKV-TQLANDLA--AQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLE 1332

Query: 628  SASGSSS 634
              + S S
Sbjct: 1333 KETKSQS 1339



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 85/435 (19%), Positives = 185/435 (42%), Gaps = 32/435 (7%)

Query: 220  KSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNAD-HSKSDR 278
            + HE S   L+    + EVQ+L+ E+  L    K T EE    +  + + N +   +   
Sbjct: 1470 QKHEESQALLDAS--QKEVQALSTELLKL----KNTYEESIVGQETLRRENKNLQEEISN 1523

Query: 279  MTRGLRAQVDDLTEAVAAK---DSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQD 335
            +T  +R    +LTE    K   + +   ++V L+E +  L      +   Q E      +
Sbjct: 1524 LTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAE 1583

Query: 336  QSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITL 395
                 S +++ ++ F+ +      +L+   +S  + + E      K+E +   +   ++ 
Sbjct: 1584 LERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSC 1643

Query: 396  AERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKAT------RILQSKEKLINSL 449
            A R+ S+  K + +LQ Q+K  ++ L+ S Q   D K++         +LQS+ + + SL
Sbjct: 1644 ANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSL 1703

Query: 450  KEGSGFEGLDSSTASSMELEE-----------LRHEKEMQREEIQKLMGQIHQLRSELQD 498
            +E +   G   S    +E  E           L  +K+    ++ ++  +  ++  E Q+
Sbjct: 1704 QEQTE-RGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQN 1762

Query: 499  MEAQQVN---EAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNT 555
             E +      EA +  E+L+   D IA  + +++ +E  +  L++     E+        
Sbjct: 1763 AEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRK 1822

Query: 556  LQSRIKDRDEEIQ-KLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNS 614
               +++ R  E++ +L  ++     +      LE  + +LT    + +  L  + T+ + 
Sbjct: 1823 QIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDK 1882

Query: 615  LVFQLERLEQQMNSA 629
            L  +++  +QQ+  A
Sbjct: 1883 LQLKVQNYKQQVEVA 1897



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 83/412 (20%), Positives = 175/412 (42%), Gaps = 41/412 (9%)

Query: 214  TPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADH 273
            T +    +H L   + +  LLR + +   QE+ + L R+      L+K  A + +W   +
Sbjct: 1335 TKSQSALAHALQKAQRDCDLLREQYEE-EQEVKAELHRT------LSKVNAEMVQWRMKY 1387

Query: 274  SKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIM 333
              +      +  + +DL +A          L +RLQEA + +        +L  E++R  
Sbjct: 1388 ENN------VIQRTEDLEDAKKE-------LAIRLQEAAEAMGVANARNASL--ERARHQ 1432

Query: 334  QDQSEGNSLQNQA-LQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEA 392
                 G++L +   +++   RL +      +    +KQ   E  A L+  + E Q L+  
Sbjct: 1433 LQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTE 1492

Query: 393  ITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEG 452
            +   +  Y +     + L+++ K    NL+     L +  ++ T+ L   EK+   ++E 
Sbjct: 1493 LLKLKNTYEESIVGQETLRRENK----NLQEEISNLTNQVREGTKNLTEMEKVKKLIEE- 1547

Query: 453  SGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESARE 512
                     T   + LEE     E    +I     ++ + ++EL+   +++  E E+ R 
Sbjct: 1548 -------EKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRR 1600

Query: 513  QLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTL---QSRIKDRDEEIQK 569
            + Q   D +     S+ +   E+ RLK++   +EEDL   +  L     ++ +  + + +
Sbjct: 1601 KQQCTIDSLQSSLDSEAKSRIEVTRLKKK---MEEDLNEMELQLSCANRQVSEATKSLGQ 1657

Query: 570  LRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLER 621
            L+ Q+ +  +     ++L + L +      ++ ++L+S   +  SL  Q ER
Sbjct: 1658 LQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTER 1709



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 73/350 (20%), Positives = 148/350 (42%), Gaps = 60/350 (17%)

Query: 220  KSHELSNLRLENQLLRNEVQS-LNQEMASLLQRS---KETQEELNKARARVEKWNADHSK 275
            K  E+ N R + Q   + +QS L+ E  S ++ +   K+ +E+LN+   ++   N   S+
Sbjct: 1591 KDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSE 1650

Query: 276  SDRMTRGLRAQV--------------DDLTEAVAAKDSQLAVLKVRLQEADQLLS----- 316
            + +    L+ Q+               DL E VA  + + ++L+  L++   L       
Sbjct: 1651 ATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERG 1710

Query: 317  ---TRTEALEA-------------LQSEKSRIMQD----QSEGNSLQNQALQTFQERLHE 356
               +  E LEA             L S+K ++  D    Q E   +  Q  Q  +E+  +
Sbjct: 1711 RRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVV-QECQNAEEKAKK 1769

Query: 357  ADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSD--------EKKRVD 408
            A        E  K+ Q   A     +E  R+N+ + IT  +++ ++         +K++ 
Sbjct: 1770 AAIEAANLSEELKKKQDTIA----HLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQ 1825

Query: 409  ELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMEL 468
            +L+ +V+  +  LE   +   + ++ A R+ +  ++L    +E    + L S   + M+ 
Sbjct: 1826 KLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDK--KNL-SRMQTQMDK 1882

Query: 469  EELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNE-AESAREQLQDL 517
             +L+ +   Q+ E+ +     +  + + Q  E  +V E AE A  Q+  L
Sbjct: 1883 LQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKL 1932



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 70/388 (18%), Positives = 150/388 (38%), Gaps = 43/388 (11%)

Query: 111  VRRKKSEPDDEL---------LFDFLNSS-QKEPTGRVEIRKEKGKTPVFQSSQTSSVSS 160
            + RK SE D+E+           D L SS   E   R+E+ + K K     +     +S 
Sbjct: 1584 LERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSC 1643

Query: 161  VNPSVTTIKT------IEENSFGSQTHEAASNSDSSHEGQEESSKENVSSNAACPDHTPT 214
             N  V+          I+      Q  ++   +    E    + + N    +   D    
Sbjct: 1644 ANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSL 1703

Query: 215  PNDDGKSHELSNLRLENQLLR--NEVQSLNQEMASLLQRSKETQEELNKARARVEKWNAD 272
                 +   LS    E +LL     +     +  SLL + K+ + ++ + +   E+   +
Sbjct: 1704 QEQTERGRRLS----EEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQE 1759

Query: 273  HSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRI 332
               ++   +    +  +L+E +  K   +A L+   +  +Q ++   + L   ++E+  +
Sbjct: 1760 CQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLA--EAEQMAL 1817

Query: 333  MQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEA 392
            M  + +        +Q  + R+ E +  L+ E     + Q   A RL +   E    AE 
Sbjct: 1818 MGSRKQ--------IQKLESRVRELEGELEGEIRRSAEAQRG-ARRLERCIKELTYQAE- 1867

Query: 393  ITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEG 452
                     ++KK +  +Q Q+   +L +++ KQ++   + +A + L   +K  + L E 
Sbjct: 1868 ---------EDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEV 1918

Query: 453  SGFEGLDSSTASSMELEELRHEKEMQRE 480
                 +  S  + ++++     K++Q E
Sbjct: 1919 KERAEVAESQVNKLKIKAREFGKKVQEE 1946


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 93/422 (22%), Positives = 194/422 (45%), Gaps = 29/422 (6%)

Query: 236  NEVQSLNQEMASLLQRSKETQEEL-NKARARVEKWNADHSKSDRMTRG---LRAQVDDLT 291
            +E +   +E A  L+  +E +     +A A  ++        DR+ RG   L+ ++DD T
Sbjct: 1399 SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDAT 1458

Query: 292  EAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQ 351
              +  +   ++ L+ + ++ DQLL+    A+     E+ R    ++EG   + +AL   +
Sbjct: 1459 MDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERA---EAEGREREARALSLTR 1515

Query: 352  --ERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDE 409
              E   EA   L+R+  + +       +  + V      L  A  +AE+  +D + +V E
Sbjct: 1516 ALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTE 1575

Query: 410  LQQQVKLY---KLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSM 466
            L+ ++      KL LE + Q L   K +  R LQ +++     +     +  D+     +
Sbjct: 1576 LEDELTAAEDAKLRLEVTVQAL---KTQHERDLQGRDEAGEERRRQLAKQLRDAE----V 1628

Query: 467  ELEELRHEKEMQREEIQKLMGQIHQLRSELQDM---EAQQVNEAESAREQLQDLHDQIAG 523
            E +E R ++ +     +KL G++ +L++++      + + V +    + Q+++L  ++  
Sbjct: 1629 ERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEE 1688

Query: 524  QKASKQEL-------ETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTN 576
             + S++E+       E  L+ L+ E   ++E+L  +    +   +DRDE   ++ N   +
Sbjct: 1689 TRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLS 1748

Query: 577  KTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNG 636
            K      + +LE RL QL E L ++Q+  E L+     L+ Q+E L  ++++    S+  
Sbjct: 1749 KAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKA 1808

Query: 637  SS 638
             S
Sbjct: 1809 ES 1810



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 146/674 (21%), Positives = 272/674 (40%), Gaps = 118/674 (17%)

Query: 12   EDLLNRVDQGAATALSRKDNASNIYSK-NTDYTELHQQNTDLIYQTGPKSTYISSAADNI 70
            ED L + ++G       K       S+      E  Q+  +L  Q G K   + +A    
Sbjct: 1065 EDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARA 1124

Query: 71   RNQKATILAGTANVKVGSRTPVEASHPVENASVPRPSSHFVRRKKSEPDDELLFDFLNSS 130
             ++         +++       EA   +E+  V R  +   RR   E + E L   L  +
Sbjct: 1125 EDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGE-ELEALRGELEDT 1183

Query: 131  QKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIK-TIEENSFGSQTHEAASNSDS 189
                  + E+R ++ +                  VT +K T+EE +   + HEAA     
Sbjct: 1184 LDSTNAQQELRSKREQ-----------------EVTELKKTLEEET---RIHEAAVQELR 1223

Query: 190  SHEGQEESSKENVSSNAACPDHTPTPNDDGK-SHELSNLRLENQL--LRNEVQSLNQEMA 246
               GQ           A            GK + E + L LE ++  LR E+ SL     
Sbjct: 1224 QRHGQALGELAEQLEQAR----------RGKGAWEKTRLALEAEVSELRAELSSLQTARQ 1273

Query: 247  SLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDS------- 299
               QR +  + +L + + R        +++    +  +A++++++ A+   +S       
Sbjct: 1274 EGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK 1333

Query: 300  QLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEG--NSLQNQA---------LQ 348
            +L+  + +L +A +LL   T A  AL S + R M+ ++ G    L+ +A         LQ
Sbjct: 1334 ELSSTEAQLHDAQELLQEETRAKLALGS-RVRAMEAEAAGLREQLEEEAAARERAGRELQ 1392

Query: 349  TFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVD 408
            T Q +L E           +++ Q E A  L   E  R+  A       ++ +++ + VD
Sbjct: 1393 TAQAQLSE-----------WRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVD 1441

Query: 409  -------ELQQQVKLYKLNLESSKQ--ELIDYKQKATRILQSKEK--LINSLKEGSGFEG 457
                    LQQ++    ++LE  +Q    ++ KQ+    L ++EK  ++ +++E    E 
Sbjct: 1442 RLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEA 1501

Query: 458  LD-SSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQ------DMEAQQVNEAESA 510
                  A ++ L     E++  REE+++   Q   LR+EL+      D   + V+E E A
Sbjct: 1502 EGREREARALSLTRALEEEQEAREELER---QNRALRAELEALLSSKDDVGKSVHELERA 1558

Query: 511  -----------REQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLY-------RT 552
                       R Q+ +L D++   + +K  LE  ++ LK +    E DL          
Sbjct: 1559 CRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH---ERDLQGRDEAGEER 1615

Query: 553  KNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEK 612
            +  L  +++D + E  + R Q   +TL+ +++ +LE  L +L       +  + S    K
Sbjct: 1616 RRQLAKQLRDAEVERDEERKQ---RTLAVAARKKLEGELEEL-------KAQMASAGQGK 1665

Query: 613  NSLVFQLERLEQQM 626
               V QL +++ QM
Sbjct: 1666 EEAVKQLRKMQAQM 1679



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 111/497 (22%), Positives = 194/497 (39%), Gaps = 50/497 (10%)

Query: 127  LNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASN 186
            L +  +E  GR+  RK++ +  V  S   + V         ++T E+        E  ++
Sbjct: 927  LCAEAEETRGRLAARKQELELVV--SELEARVGEEEECSRQMQT-EKKRLQQHIQELEAH 983

Query: 187  SDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMA 246
             ++    +++   E V++ A                +L  L  +N  L  E + L   +A
Sbjct: 984  LEAEEGARQKLQLEKVTTEAKMKKF---------EEDLLLLEDQNSKLSKERKLLEDRLA 1034

Query: 247  SLLQRSKETQEE---LNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAV 303
                ++ E +E+   LNK R + E   AD     R     R +++ L   +  + S+L  
Sbjct: 1035 EFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE 1094

Query: 304  LKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKR 363
              V  Q+       R E L A    K   +Q        +  A     + L EA A L  
Sbjct: 1095 QMVEQQQ-------RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAE 1147

Query: 364  EQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSD--------EKKRVDELQQQVK 415
             QE    ++SE  AR  K E +R++L E +     +  D        ++ R    Q+  +
Sbjct: 1148 AQED---LESERVAR-TKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1203

Query: 416  LYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEK 475
            L K   E ++      ++   R  Q+  +L   L++    +G    T  ++E E      
Sbjct: 1204 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1263

Query: 476  EMQREEIQKLMGQIHQLRSELQDMEAQ-QVNEAESAR----EQLQDLHDQIAGQKASKQE 530
            E+   +  +  G+  + R ELQ  E Q +  + E AR    E+LQ    ++     +  E
Sbjct: 1264 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNE 1323

Query: 531  LETELERLKQEFHYIEEDLY----------RTKNTLQSRIKDRDEEIQKLRNQLTNKTLS 580
             E++  RL +E    E  L+          R K  L SR++  + E   LR QL  +  +
Sbjct: 1324 AESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAA 1383

Query: 581  NS-SQSELENRLHQLTE 596
               +  EL+    QL+E
Sbjct: 1384 RERAGRELQTAQAQLSE 1400



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 98/416 (23%), Positives = 179/416 (43%), Gaps = 57/416 (13%)

Query: 256  QEELNKARAR-VEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQL---AVLKVRLQEA 311
            Q+E+ +ARA+ ++K      +S R    L+ +V  L E  A    QL   A L    +E 
Sbjct: 875  QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 934

Query: 312  DQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQM 371
               L+ R + LE + SE    + ++ E +       +  Q+ + E +A L+ E+ + +++
Sbjct: 935  RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKL 994

Query: 372  QSEFAARLNKVEMERQNLAEAITLAE---RKYSDEKKRVDELQQQVKLYKLNLESSKQEL 428
            Q E        E + +   E + L E    K S E+K +++     +L + + +++++E 
Sbjct: 995  QLEKVT----TEAKMKKFEEDLLLLEDQNSKLSKERKLLED-----RLAEFSSQAAEEE- 1044

Query: 429  IDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQ 488
                         K K +N L+            A+  ++E+   ++E  R+E++KL  +
Sbjct: 1045 ------------EKVKSLNKLRL--------KYEATIADMEDRLRKEEKGRQELEKLKRR 1084

Query: 489  IHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKA-------SKQELETELERLKQE 541
            +    SELQ+   +Q   AE  R QL    +++    A       ++ +L   L   +  
Sbjct: 1085 LDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAA 1144

Query: 542  FHYIEEDL-----YRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTE 596
                +EDL      RTK   Q R  D  EE++ LR +L +   S ++Q EL ++  Q  E
Sbjct: 1145 LAEAQEDLESERVARTKAEKQRR--DLGEELEALRGELEDTLDSTNAQQELRSKREQ--E 1200

Query: 597  TLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRL 652
                K+T+ E     + +    ++ L Q+   A G  +        G    E TRL
Sbjct: 1201 VTELKKTLEEETRIHEAA----VQELRQRHGQALGELAEQLEQARRGKGAWEKTRL 1252



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 66/327 (20%), Positives = 156/327 (47%), Gaps = 38/327 (11%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARV-EKWN-------------ADHSKSDRM 279
            L  E++ L  +MAS  Q  +E  ++L K +A++ E W              + + +S++ 
Sbjct: 1647 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR 1706

Query: 280  TRGLRAQVDDLTEAVAAKD-SQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSE 338
             +GL A+V  L E +AA D ++    + R + AD++ +        L+ ++      Q E
Sbjct: 1707 LKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR------QLE 1760

Query: 339  GNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAIT---L 395
            G       L   +E L E  +  +   + Y+++  +  +   ++  ER   A+A +    
Sbjct: 1761 GR------LGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ 1814

Query: 396  AERKYSDEKKRVDELQQQVKL-YKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSG 454
             ER+  + + R+ E     +  +K+ + + + +L   +++  +  +++E++++       
Sbjct: 1815 LERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ--ETRERILSGKLVRRA 1872

Query: 455  FEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQL 514
             + L       +++EE R   +  R++++K   ++ QL+ +L++ E ++ + A++ R +L
Sbjct: 1873 EKRLKEVV---LQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAE-EEASRAQAGRRRL 1928

Query: 515  Q-DLHDQIAGQKASKQELETELERLKQ 540
            Q +L D     ++  +E+ T   RL++
Sbjct: 1929 QRELEDVTESAESMNREVTTLRNRLRR 1955



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 86/441 (19%), Positives = 181/441 (41%), Gaps = 71/441 (16%)

Query: 188  DSSHEGQEESSKENVSSNAACPDHTPTPNDDGKS-HELSNL-RLENQL---LRNEVQSLN 242
            +   E +EE  ++N +  A       + +D GKS HEL    R+  Q    LR +V  L 
Sbjct: 1518 EEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELE 1577

Query: 243  QEMASLLQRSKETQEELNKARARVEKW-----NADHSKSDRMTRGLR-AQVD------DL 290
             E+ +        +  +   + + E+       A   +  ++ + LR A+V+        
Sbjct: 1578 DELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQR 1637

Query: 291  TEAVAAK---DSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQAL 347
            T AVAA+   + +L  LK ++  A Q      + L  +Q++   + ++  E  + + +  
Sbjct: 1638 TLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIF 1697

Query: 348  QT-----------------FQERLHEADATLKREQESYKQMQSEFA-ARLNKVEM--ERQ 387
                                QE L  +D   ++ Q+   +M  E A   L+K  +  E++
Sbjct: 1698 SQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR 1757

Query: 388  NLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELI---DYKQKATRILQSKEK 444
             L   +   E +  +E+   + L  + +   L +ES   EL     +  KA    Q  E+
Sbjct: 1758 QLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER 1817

Query: 445  LINSLK-----EGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMG------------ 487
             I  L+     E +G       T +++E +  + E+++++E  ++++             
Sbjct: 1818 QIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLK 1877

Query: 488  ----QIHQLR---SELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQ 540
                Q+ + R    +L+D   +     +  + QL++  ++ +  +A ++ L+ ELE + +
Sbjct: 1878 EVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTE 1937

Query: 541  EFHYIEEDLYRTKNTLQSRIK 561
                  E + R   TL++R++
Sbjct: 1938 S----AESMNREVTTLRNRLR 1954



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 57/293 (19%), Positives = 127/293 (43%), Gaps = 33/293 (11%)

Query: 346  ALQTFQERLHEADA--TLKREQESYKQMQSEFAARL-NKVEMERQNLAEAITLAERKYSD 402
            A + FQ+R  +  A   ++R   +Y +++     RL  KV+   Q   +   L  R  + 
Sbjct: 827  ARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQAR--AQ 884

Query: 403  EKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSST 462
            E ++V ELQQQ          S +E+ + + +  ++ + + +L   L+         +  
Sbjct: 885  ELQKVQELQQQ----------SAREVGELQGRVAQLEEERARLAEQLR---------AEA 925

Query: 463  ASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIA 522
                E EE R     +++E++ ++ ++     E ++   Q   E +  ++ +Q+L   + 
Sbjct: 926  ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 985

Query: 523  GQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNS 582
             ++ ++Q+L+ E    + +    EEDL          ++D++ ++ K R  L ++    S
Sbjct: 986  AEEGARQKLQLEKVTTEAKMKKFEEDLL--------LLEDQNSKLSKERKLLEDRLAEFS 1037

Query: 583  SQ-SELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSS 634
            SQ +E E ++  L +  ++ +  +  +           + LE+      G SS
Sbjct: 1038 SQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1090



 Score = 33.5 bits (75), Expect = 0.72
 Identities = 20/86 (23%), Positives = 45/86 (52%), Gaps = 14/86 (16%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEA 293
            LR++++  N  +  L ++ +E +EE ++A+A                R L+ +++D+TE+
Sbjct: 1893 LRDQLEKGNLRVKQLKRQLEEAEEEASRAQAG--------------RRRLQRELEDVTES 1938

Query: 294  VAAKDSQLAVLKVRLQEADQLLSTRT 319
              + + ++  L+ RL+      +TRT
Sbjct: 1939 AESMNREVTTLRNRLRRGPLTFTTRT 1964


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 93/422 (22%), Positives = 194/422 (45%), Gaps = 29/422 (6%)

Query: 236  NEVQSLNQEMASLLQRSKETQEEL-NKARARVEKWNADHSKSDRMTRG---LRAQVDDLT 291
            +E +   +E A  L+  +E +     +A A  ++        DR+ RG   L+ ++DD T
Sbjct: 1391 SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDAT 1450

Query: 292  EAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQ 351
              +  +   ++ L+ + ++ DQLL+    A+     E+ R    ++EG   + +AL   +
Sbjct: 1451 MDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERA---EAEGREREARALSLTR 1507

Query: 352  --ERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDE 409
              E   EA   L+R+  + +       +  + V      L  A  +AE+  +D + +V E
Sbjct: 1508 ALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTE 1567

Query: 410  LQQQVKLY---KLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSM 466
            L+ ++      KL LE + Q L   K +  R LQ +++     +     +  D+     +
Sbjct: 1568 LEDELTAAEDAKLRLEVTVQAL---KTQHERDLQGRDEAGEERRRQLAKQLRDAE----V 1620

Query: 467  ELEELRHEKEMQREEIQKLMGQIHQLRSELQDM---EAQQVNEAESAREQLQDLHDQIAG 523
            E +E R ++ +     +KL G++ +L++++      + + V +    + Q+++L  ++  
Sbjct: 1621 ERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEE 1680

Query: 524  QKASKQEL-------ETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTN 576
             + S++E+       E  L+ L+ E   ++E+L  +    +   +DRDE   ++ N   +
Sbjct: 1681 TRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLS 1740

Query: 577  KTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNG 636
            K      + +LE RL QL E L ++Q+  E L+     L+ Q+E L  ++++    S+  
Sbjct: 1741 KAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKA 1800

Query: 637  SS 638
             S
Sbjct: 1801 ES 1802



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 146/674 (21%), Positives = 272/674 (40%), Gaps = 118/674 (17%)

Query: 12   EDLLNRVDQGAATALSRKDNASNIYSK-NTDYTELHQQNTDLIYQTGPKSTYISSAADNI 70
            ED L + ++G       K       S+      E  Q+  +L  Q G K   + +A    
Sbjct: 1057 EDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARA 1116

Query: 71   RNQKATILAGTANVKVGSRTPVEASHPVENASVPRPSSHFVRRKKSEPDDELLFDFLNSS 130
             ++         +++       EA   +E+  V R  +   RR   E + E L   L  +
Sbjct: 1117 EDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGE-ELEALRGELEDT 1175

Query: 131  QKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIK-TIEENSFGSQTHEAASNSDS 189
                  + E+R ++ +                  VT +K T+EE +   + HEAA     
Sbjct: 1176 LDSTNAQQELRSKREQ-----------------EVTELKKTLEEET---RIHEAAVQELR 1215

Query: 190  SHEGQEESSKENVSSNAACPDHTPTPNDDGK-SHELSNLRLENQL--LRNEVQSLNQEMA 246
               GQ           A            GK + E + L LE ++  LR E+ SL     
Sbjct: 1216 QRHGQALGELAEQLEQAR----------RGKGAWEKTRLALEAEVSELRAELSSLQTARQ 1265

Query: 247  SLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDS------- 299
               QR +  + +L + + R        +++    +  +A++++++ A+   +S       
Sbjct: 1266 EGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK 1325

Query: 300  QLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEG--NSLQNQA---------LQ 348
            +L+  + +L +A +LL   T A  AL S + R M+ ++ G    L+ +A         LQ
Sbjct: 1326 ELSSTEAQLHDAQELLQEETRAKLALGS-RVRAMEAEAAGLREQLEEEAAARERAGRELQ 1384

Query: 349  TFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVD 408
            T Q +L E           +++ Q E A  L   E  R+  A       ++ +++ + VD
Sbjct: 1385 TAQAQLSE-----------WRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVD 1433

Query: 409  -------ELQQQVKLYKLNLESSKQ--ELIDYKQKATRILQSKEK--LINSLKEGSGFEG 457
                    LQQ++    ++LE  +Q    ++ KQ+    L ++EK  ++ +++E    E 
Sbjct: 1434 RLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEA 1493

Query: 458  LD-SSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQ------DMEAQQVNEAESA 510
                  A ++ L     E++  REE+++   Q   LR+EL+      D   + V+E E A
Sbjct: 1494 EGREREARALSLTRALEEEQEAREELER---QNRALRAELEALLSSKDDVGKSVHELERA 1550

Query: 511  -----------REQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLY-------RT 552
                       R Q+ +L D++   + +K  LE  ++ LK +    E DL          
Sbjct: 1551 CRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH---ERDLQGRDEAGEER 1607

Query: 553  KNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEK 612
            +  L  +++D + E  + R Q   +TL+ +++ +LE  L +L       +  + S    K
Sbjct: 1608 RRQLAKQLRDAEVERDEERKQ---RTLAVAARKKLEGELEEL-------KAQMASAGQGK 1657

Query: 613  NSLVFQLERLEQQM 626
               V QL +++ QM
Sbjct: 1658 EEAVKQLRKMQAQM 1671



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 111/497 (22%), Positives = 194/497 (39%), Gaps = 50/497 (10%)

Query: 127  LNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASN 186
            L +  +E  GR+  RK++ +  V  S   + V         ++T E+        E  ++
Sbjct: 919  LCAEAEETRGRLAARKQELELVV--SELEARVGEEEECSRQMQT-EKKRLQQHIQELEAH 975

Query: 187  SDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMA 246
             ++    +++   E V++ A                +L  L  +N  L  E + L   +A
Sbjct: 976  LEAEEGARQKLQLEKVTTEAKMKKF---------EEDLLLLEDQNSKLSKERKLLEDRLA 1026

Query: 247  SLLQRSKETQEE---LNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAV 303
                ++ E +E+   LNK R + E   AD     R     R +++ L   +  + S+L  
Sbjct: 1027 EFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE 1086

Query: 304  LKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKR 363
              V  Q+       R E L A    K   +Q        +  A     + L EA A L  
Sbjct: 1087 QMVEQQQ-------RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAE 1139

Query: 364  EQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSD--------EKKRVDELQQQVK 415
             QE    ++SE  AR  K E +R++L E +     +  D        ++ R    Q+  +
Sbjct: 1140 AQED---LESERVAR-TKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1195

Query: 416  LYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEK 475
            L K   E ++      ++   R  Q+  +L   L++    +G    T  ++E E      
Sbjct: 1196 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1255

Query: 476  EMQREEIQKLMGQIHQLRSELQDMEAQ-QVNEAESAR----EQLQDLHDQIAGQKASKQE 530
            E+   +  +  G+  + R ELQ  E Q +  + E AR    E+LQ    ++     +  E
Sbjct: 1256 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNE 1315

Query: 531  LETELERLKQEFHYIEEDLY----------RTKNTLQSRIKDRDEEIQKLRNQLTNKTLS 580
             E++  RL +E    E  L+          R K  L SR++  + E   LR QL  +  +
Sbjct: 1316 AESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAA 1375

Query: 581  NS-SQSELENRLHQLTE 596
               +  EL+    QL+E
Sbjct: 1376 RERAGRELQTAQAQLSE 1392



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 98/416 (23%), Positives = 179/416 (43%), Gaps = 57/416 (13%)

Query: 256  QEELNKARAR-VEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQL---AVLKVRLQEA 311
            Q+E+ +ARA+ ++K      +S R    L+ +V  L E  A    QL   A L    +E 
Sbjct: 867  QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 926

Query: 312  DQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQM 371
               L+ R + LE + SE    + ++ E +       +  Q+ + E +A L+ E+ + +++
Sbjct: 927  RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKL 986

Query: 372  QSEFAARLNKVEMERQNLAEAITLAE---RKYSDEKKRVDELQQQVKLYKLNLESSKQEL 428
            Q E        E + +   E + L E    K S E+K +++     +L + + +++++E 
Sbjct: 987  QLEKVT----TEAKMKKFEEDLLLLEDQNSKLSKERKLLED-----RLAEFSSQAAEEE- 1036

Query: 429  IDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQ 488
                         K K +N L+            A+  ++E+   ++E  R+E++KL  +
Sbjct: 1037 ------------EKVKSLNKLRL--------KYEATIADMEDRLRKEEKGRQELEKLKRR 1076

Query: 489  IHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKA-------SKQELETELERLKQE 541
            +    SELQ+   +Q   AE  R QL    +++    A       ++ +L   L   +  
Sbjct: 1077 LDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAA 1136

Query: 542  FHYIEEDL-----YRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTE 596
                +EDL      RTK   Q R  D  EE++ LR +L +   S ++Q EL ++  Q  E
Sbjct: 1137 LAEAQEDLESERVARTKAEKQRR--DLGEELEALRGELEDTLDSTNAQQELRSKREQ--E 1192

Query: 597  TLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRL 652
                K+T+ E     + +    ++ L Q+   A G  +        G    E TRL
Sbjct: 1193 VTELKKTLEEETRIHEAA----VQELRQRHGQALGELAEQLEQARRGKGAWEKTRL 1244



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 66/327 (20%), Positives = 156/327 (47%), Gaps = 38/327 (11%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARV-EKWN-------------ADHSKSDRM 279
            L  E++ L  +MAS  Q  +E  ++L K +A++ E W              + + +S++ 
Sbjct: 1639 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR 1698

Query: 280  TRGLRAQVDDLTEAVAAKD-SQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSE 338
             +GL A+V  L E +AA D ++    + R + AD++ +        L+ ++      Q E
Sbjct: 1699 LKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR------QLE 1752

Query: 339  GNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAIT---L 395
            G       L   +E L E  +  +   + Y+++  +  +   ++  ER   A+A +    
Sbjct: 1753 GR------LGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ 1806

Query: 396  AERKYSDEKKRVDELQQQVKL-YKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSG 454
             ER+  + + R+ E     +  +K+ + + + +L   +++  +  +++E++++       
Sbjct: 1807 LERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ--ETRERILSGKLVRRA 1864

Query: 455  FEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQL 514
             + L       +++EE R   +  R++++K   ++ QL+ +L++ E ++ + A++ R +L
Sbjct: 1865 EKRLKEVV---LQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAE-EEASRAQAGRRRL 1920

Query: 515  Q-DLHDQIAGQKASKQELETELERLKQ 540
            Q +L D     ++  +E+ T   RL++
Sbjct: 1921 QRELEDVTESAESMNREVTTLRNRLRR 1947



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 86/441 (19%), Positives = 181/441 (41%), Gaps = 71/441 (16%)

Query: 188  DSSHEGQEESSKENVSSNAACPDHTPTPNDDGKS-HELSNL-RLENQL---LRNEVQSLN 242
            +   E +EE  ++N +  A       + +D GKS HEL    R+  Q    LR +V  L 
Sbjct: 1510 EEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELE 1569

Query: 243  QEMASLLQRSKETQEELNKARARVEKW-----NADHSKSDRMTRGLR-AQVD------DL 290
             E+ +        +  +   + + E+       A   +  ++ + LR A+V+        
Sbjct: 1570 DELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQR 1629

Query: 291  TEAVAAK---DSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQAL 347
            T AVAA+   + +L  LK ++  A Q      + L  +Q++   + ++  E  + + +  
Sbjct: 1630 TLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIF 1689

Query: 348  QT-----------------FQERLHEADATLKREQESYKQMQSEFA-ARLNKVEM--ERQ 387
                                QE L  +D   ++ Q+   +M  E A   L+K  +  E++
Sbjct: 1690 SQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR 1749

Query: 388  NLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELI---DYKQKATRILQSKEK 444
             L   +   E +  +E+   + L  + +   L +ES   EL     +  KA    Q  E+
Sbjct: 1750 QLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER 1809

Query: 445  LINSLK-----EGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMG------------ 487
             I  L+     E +G       T +++E +  + E+++++E  ++++             
Sbjct: 1810 QIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLK 1869

Query: 488  ----QIHQLR---SELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQ 540
                Q+ + R    +L+D   +     +  + QL++  ++ +  +A ++ L+ ELE + +
Sbjct: 1870 EVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTE 1929

Query: 541  EFHYIEEDLYRTKNTLQSRIK 561
                  E + R   TL++R++
Sbjct: 1930 S----AESMNREVTTLRNRLR 1946



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 57/293 (19%), Positives = 127/293 (43%), Gaps = 33/293 (11%)

Query: 346  ALQTFQERLHEADA--TLKREQESYKQMQSEFAARL-NKVEMERQNLAEAITLAERKYSD 402
            A + FQ+R  +  A   ++R   +Y +++     RL  KV+   Q   +   L  R  + 
Sbjct: 819  ARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQAR--AQ 876

Query: 403  EKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSST 462
            E ++V ELQQQ          S +E+ + + +  ++ + + +L   L+         +  
Sbjct: 877  ELQKVQELQQQ----------SAREVGELQGRVAQLEEERARLAEQLR---------AEA 917

Query: 463  ASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIA 522
                E EE R     +++E++ ++ ++     E ++   Q   E +  ++ +Q+L   + 
Sbjct: 918  ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 977

Query: 523  GQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNS 582
             ++ ++Q+L+ E    + +    EEDL          ++D++ ++ K R  L ++    S
Sbjct: 978  AEEGARQKLQLEKVTTEAKMKKFEEDLL--------LLEDQNSKLSKERKLLEDRLAEFS 1029

Query: 583  SQ-SELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSS 634
            SQ +E E ++  L +  ++ +  +  +           + LE+      G SS
Sbjct: 1030 SQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1082



 Score = 33.5 bits (75), Expect = 0.72
 Identities = 20/86 (23%), Positives = 45/86 (52%), Gaps = 14/86 (16%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEA 293
            LR++++  N  +  L ++ +E +EE ++A+A                R L+ +++D+TE+
Sbjct: 1885 LRDQLEKGNLRVKQLKRQLEEAEEEASRAQAG--------------RRRLQRELEDVTES 1930

Query: 294  VAAKDSQLAVLKVRLQEADQLLSTRT 319
              + + ++  L+ RL+      +TRT
Sbjct: 1931 AESMNREVTTLRNRLRRGPLTFTTRT 1956


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 93/422 (22%), Positives = 194/422 (45%), Gaps = 29/422 (6%)

Query: 236  NEVQSLNQEMASLLQRSKETQEEL-NKARARVEKWNADHSKSDRMTRG---LRAQVDDLT 291
            +E +   +E A  L+  +E +     +A A  ++        DR+ RG   L+ ++DD T
Sbjct: 1432 SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDAT 1491

Query: 292  EAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQ 351
              +  +   ++ L+ + ++ DQLL+    A+     E+ R    ++EG   + +AL   +
Sbjct: 1492 MDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERA---EAEGREREARALSLTR 1548

Query: 352  --ERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDE 409
              E   EA   L+R+  + +       +  + V      L  A  +AE+  +D + +V E
Sbjct: 1549 ALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTE 1608

Query: 410  LQQQVKLY---KLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSM 466
            L+ ++      KL LE + Q L   K +  R LQ +++     +     +  D+     +
Sbjct: 1609 LEDELTAAEDAKLRLEVTVQAL---KTQHERDLQGRDEAGEERRRQLAKQLRDAE----V 1661

Query: 467  ELEELRHEKEMQREEIQKLMGQIHQLRSELQDM---EAQQVNEAESAREQLQDLHDQIAG 523
            E +E R ++ +     +KL G++ +L++++      + + V +    + Q+++L  ++  
Sbjct: 1662 ERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEE 1721

Query: 524  QKASKQEL-------ETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTN 576
             + S++E+       E  L+ L+ E   ++E+L  +    +   +DRDE   ++ N   +
Sbjct: 1722 TRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLS 1781

Query: 577  KTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNG 636
            K      + +LE RL QL E L ++Q+  E L+     L+ Q+E L  ++++    S+  
Sbjct: 1782 KAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKA 1841

Query: 637  SS 638
             S
Sbjct: 1842 ES 1843



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 146/674 (21%), Positives = 272/674 (40%), Gaps = 118/674 (17%)

Query: 12   EDLLNRVDQGAATALSRKDNASNIYSK-NTDYTELHQQNTDLIYQTGPKSTYISSAADNI 70
            ED L + ++G       K       S+      E  Q+  +L  Q G K   + +A    
Sbjct: 1098 EDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARA 1157

Query: 71   RNQKATILAGTANVKVGSRTPVEASHPVENASVPRPSSHFVRRKKSEPDDELLFDFLNSS 130
             ++         +++       EA   +E+  V R  +   RR   E + E L   L  +
Sbjct: 1158 EDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGE-ELEALRGELEDT 1216

Query: 131  QKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIK-TIEENSFGSQTHEAASNSDS 189
                  + E+R ++ +                  VT +K T+EE +   + HEAA     
Sbjct: 1217 LDSTNAQQELRSKREQ-----------------EVTELKKTLEEET---RIHEAAVQELR 1256

Query: 190  SHEGQEESSKENVSSNAACPDHTPTPNDDGK-SHELSNLRLENQL--LRNEVQSLNQEMA 246
               GQ           A            GK + E + L LE ++  LR E+ SL     
Sbjct: 1257 QRHGQALGELAEQLEQAR----------RGKGAWEKTRLALEAEVSELRAELSSLQTARQ 1306

Query: 247  SLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDS------- 299
               QR +  + +L + + R        +++    +  +A++++++ A+   +S       
Sbjct: 1307 EGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK 1366

Query: 300  QLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEG--NSLQNQA---------LQ 348
            +L+  + +L +A +LL   T A  AL S + R M+ ++ G    L+ +A         LQ
Sbjct: 1367 ELSSTEAQLHDAQELLQEETRAKLALGS-RVRAMEAEAAGLREQLEEEAAARERAGRELQ 1425

Query: 349  TFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVD 408
            T Q +L E           +++ Q E A  L   E  R+  A       ++ +++ + VD
Sbjct: 1426 TAQAQLSE-----------WRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVD 1474

Query: 409  -------ELQQQVKLYKLNLESSKQ--ELIDYKQKATRILQSKEK--LINSLKEGSGFEG 457
                    LQQ++    ++LE  +Q    ++ KQ+    L ++EK  ++ +++E    E 
Sbjct: 1475 RLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEA 1534

Query: 458  LD-SSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQ------DMEAQQVNEAESA 510
                  A ++ L     E++  REE+++   Q   LR+EL+      D   + V+E E A
Sbjct: 1535 EGREREARALSLTRALEEEQEAREELER---QNRALRAELEALLSSKDDVGKSVHELERA 1591

Query: 511  -----------REQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLY-------RT 552
                       R Q+ +L D++   + +K  LE  ++ LK +    E DL          
Sbjct: 1592 CRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH---ERDLQGRDEAGEER 1648

Query: 553  KNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEK 612
            +  L  +++D + E  + R Q   +TL+ +++ +LE  L +L       +  + S    K
Sbjct: 1649 RRQLAKQLRDAEVERDEERKQ---RTLAVAARKKLEGELEEL-------KAQMASAGQGK 1698

Query: 613  NSLVFQLERLEQQM 626
               V QL +++ QM
Sbjct: 1699 EEAVKQLRKMQAQM 1712



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 111/497 (22%), Positives = 194/497 (39%), Gaps = 50/497 (10%)

Query: 127  LNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASN 186
            L +  +E  GR+  RK++ +  V  S   + V         ++T E+        E  ++
Sbjct: 960  LCAEAEETRGRLAARKQELELVV--SELEARVGEEEECSRQMQT-EKKRLQQHIQELEAH 1016

Query: 187  SDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMA 246
             ++    +++   E V++ A                +L  L  +N  L  E + L   +A
Sbjct: 1017 LEAEEGARQKLQLEKVTTEAKMKKF---------EEDLLLLEDQNSKLSKERKLLEDRLA 1067

Query: 247  SLLQRSKETQEE---LNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAV 303
                ++ E +E+   LNK R + E   AD     R     R +++ L   +  + S+L  
Sbjct: 1068 EFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE 1127

Query: 304  LKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKR 363
              V  Q+       R E L A    K   +Q        +  A     + L EA A L  
Sbjct: 1128 QMVEQQQ-------RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAE 1180

Query: 364  EQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSD--------EKKRVDELQQQVK 415
             QE    ++SE  AR  K E +R++L E +     +  D        ++ R    Q+  +
Sbjct: 1181 AQED---LESERVAR-TKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1236

Query: 416  LYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEK 475
            L K   E ++      ++   R  Q+  +L   L++    +G    T  ++E E      
Sbjct: 1237 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1296

Query: 476  EMQREEIQKLMGQIHQLRSELQDMEAQ-QVNEAESAR----EQLQDLHDQIAGQKASKQE 530
            E+   +  +  G+  + R ELQ  E Q +  + E AR    E+LQ    ++     +  E
Sbjct: 1297 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNE 1356

Query: 531  LETELERLKQEFHYIEEDLY----------RTKNTLQSRIKDRDEEIQKLRNQLTNKTLS 580
             E++  RL +E    E  L+          R K  L SR++  + E   LR QL  +  +
Sbjct: 1357 AESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAA 1416

Query: 581  NS-SQSELENRLHQLTE 596
               +  EL+    QL+E
Sbjct: 1417 RERAGRELQTAQAQLSE 1433



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 98/416 (23%), Positives = 179/416 (43%), Gaps = 57/416 (13%)

Query: 256  QEELNKARAR-VEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQL---AVLKVRLQEA 311
            Q+E+ +ARA+ ++K      +S R    L+ +V  L E  A    QL   A L    +E 
Sbjct: 908  QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 967

Query: 312  DQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQM 371
               L+ R + LE + SE    + ++ E +       +  Q+ + E +A L+ E+ + +++
Sbjct: 968  RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKL 1027

Query: 372  QSEFAARLNKVEMERQNLAEAITLAE---RKYSDEKKRVDELQQQVKLYKLNLESSKQEL 428
            Q E        E + +   E + L E    K S E+K +++     +L + + +++++E 
Sbjct: 1028 QLEKVT----TEAKMKKFEEDLLLLEDQNSKLSKERKLLED-----RLAEFSSQAAEEE- 1077

Query: 429  IDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQ 488
                         K K +N L+            A+  ++E+   ++E  R+E++KL  +
Sbjct: 1078 ------------EKVKSLNKLRL--------KYEATIADMEDRLRKEEKGRQELEKLKRR 1117

Query: 489  IHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKA-------SKQELETELERLKQE 541
            +    SELQ+   +Q   AE  R QL    +++    A       ++ +L   L   +  
Sbjct: 1118 LDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAA 1177

Query: 542  FHYIEEDL-----YRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTE 596
                +EDL      RTK   Q R  D  EE++ LR +L +   S ++Q EL ++  Q  E
Sbjct: 1178 LAEAQEDLESERVARTKAEKQRR--DLGEELEALRGELEDTLDSTNAQQELRSKREQ--E 1233

Query: 597  TLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRL 652
                K+T+ E     + +    ++ L Q+   A G  +        G    E TRL
Sbjct: 1234 VTELKKTLEEETRIHEAA----VQELRQRHGQALGELAEQLEQARRGKGAWEKTRL 1285



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 66/327 (20%), Positives = 156/327 (47%), Gaps = 38/327 (11%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARV-EKWN-------------ADHSKSDRM 279
            L  E++ L  +MAS  Q  +E  ++L K +A++ E W              + + +S++ 
Sbjct: 1680 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR 1739

Query: 280  TRGLRAQVDDLTEAVAAKD-SQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSE 338
             +GL A+V  L E +AA D ++    + R + AD++ +        L+ ++      Q E
Sbjct: 1740 LKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR------QLE 1793

Query: 339  GNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAIT---L 395
            G       L   +E L E  +  +   + Y+++  +  +   ++  ER   A+A +    
Sbjct: 1794 GR------LGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ 1847

Query: 396  AERKYSDEKKRVDELQQQVKL-YKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSG 454
             ER+  + + R+ E     +  +K+ + + + +L   +++  +  +++E++++       
Sbjct: 1848 LERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ--ETRERILSGKLVRRA 1905

Query: 455  FEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQL 514
             + L       +++EE R   +  R++++K   ++ QL+ +L++ E ++ + A++ R +L
Sbjct: 1906 EKRLKEVV---LQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAE-EEASRAQAGRRRL 1961

Query: 515  Q-DLHDQIAGQKASKQELETELERLKQ 540
            Q +L D     ++  +E+ T   RL++
Sbjct: 1962 QRELEDVTESAESMNREVTTLRNRLRR 1988



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 86/441 (19%), Positives = 181/441 (41%), Gaps = 71/441 (16%)

Query: 188  DSSHEGQEESSKENVSSNAACPDHTPTPNDDGKS-HELSNL-RLENQL---LRNEVQSLN 242
            +   E +EE  ++N +  A       + +D GKS HEL    R+  Q    LR +V  L 
Sbjct: 1551 EEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELE 1610

Query: 243  QEMASLLQRSKETQEELNKARARVEKW-----NADHSKSDRMTRGLR-AQVD------DL 290
             E+ +        +  +   + + E+       A   +  ++ + LR A+V+        
Sbjct: 1611 DELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQR 1670

Query: 291  TEAVAAK---DSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQAL 347
            T AVAA+   + +L  LK ++  A Q      + L  +Q++   + ++  E  + + +  
Sbjct: 1671 TLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIF 1730

Query: 348  QT-----------------FQERLHEADATLKREQESYKQMQSEFA-ARLNKVEM--ERQ 387
                                QE L  +D   ++ Q+   +M  E A   L+K  +  E++
Sbjct: 1731 SQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR 1790

Query: 388  NLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELI---DYKQKATRILQSKEK 444
             L   +   E +  +E+   + L  + +   L +ES   EL     +  KA    Q  E+
Sbjct: 1791 QLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER 1850

Query: 445  LINSLK-----EGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMG------------ 487
             I  L+     E +G       T +++E +  + E+++++E  ++++             
Sbjct: 1851 QIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLK 1910

Query: 488  ----QIHQLR---SELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQ 540
                Q+ + R    +L+D   +     +  + QL++  ++ +  +A ++ L+ ELE + +
Sbjct: 1911 EVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTE 1970

Query: 541  EFHYIEEDLYRTKNTLQSRIK 561
                  E + R   TL++R++
Sbjct: 1971 S----AESMNREVTTLRNRLR 1987



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 57/293 (19%), Positives = 127/293 (43%), Gaps = 33/293 (11%)

Query: 346  ALQTFQERLHEADA--TLKREQESYKQMQSEFAARL-NKVEMERQNLAEAITLAERKYSD 402
            A + FQ+R  +  A   ++R   +Y +++     RL  KV+   Q   +   L  R  + 
Sbjct: 860  ARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQAR--AQ 917

Query: 403  EKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSST 462
            E ++V ELQQQ          S +E+ + + +  ++ + + +L   L+         +  
Sbjct: 918  ELQKVQELQQQ----------SAREVGELQGRVAQLEEERARLAEQLR---------AEA 958

Query: 463  ASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIA 522
                E EE R     +++E++ ++ ++     E ++   Q   E +  ++ +Q+L   + 
Sbjct: 959  ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 1018

Query: 523  GQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNS 582
             ++ ++Q+L+ E    + +    EEDL          ++D++ ++ K R  L ++    S
Sbjct: 1019 AEEGARQKLQLEKVTTEAKMKKFEEDLL--------LLEDQNSKLSKERKLLEDRLAEFS 1070

Query: 583  SQ-SELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSS 634
            SQ +E E ++  L +  ++ +  +  +           + LE+      G SS
Sbjct: 1071 SQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1123



 Score = 33.5 bits (75), Expect = 0.72
 Identities = 20/86 (23%), Positives = 45/86 (52%), Gaps = 14/86 (16%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEA 293
            LR++++  N  +  L ++ +E +EE ++A+A                R L+ +++D+TE+
Sbjct: 1926 LRDQLEKGNLRVKQLKRQLEEAEEEASRAQAG--------------RRRLQRELEDVTES 1971

Query: 294  VAAKDSQLAVLKVRLQEADQLLSTRT 319
              + + ++  L+ RL+      +TRT
Sbjct: 1972 AESMNREVTTLRNRLRRGPLTFTTRT 1997


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 111/436 (25%), Positives = 193/436 (44%), Gaps = 67/436 (15%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEA 293
            L +E+  L++ MASL  R +    EL +  A+ E+     +K +     L AQV+ L  A
Sbjct: 1311 LESELMELHETMASLQSRLRRA--ELQRMEAQGERELLQAAKEN-----LTAQVEHLQAA 1363

Query: 294  VA---AKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQ-- 348
            V    A+ S   +L+  L+ A   L  + E +E+ + E+++ +Q+Q E    Q +ALQ  
Sbjct: 1364 VVEARAQASAAGILEEDLRTARSALKLKNEEVES-ERERAQALQEQGELKVAQGKALQEN 1422

Query: 349  ------TFQERLHEADATLKREQESYKQMQSEFAA----------RLNKVEMERQNLAE- 391
                  T  ER  E +    + QE  KQ + + AA          R  +V+++++ + E 
Sbjct: 1423 LALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL 1482

Query: 392  ------------AITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRIL 439
                        A+   E+K + +++++ EL++  +  +  LE    EL    +K  +++
Sbjct: 1483 EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL----EKKDQMI 1538

Query: 440  QSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDM 499
            +S+   +  LK+      L +    ++ELEE  H+ E Q++ I++L GQ    R  L  +
Sbjct: 1539 ESQRGQVQDLKKQ-----LVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL 1593

Query: 500  EAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSR 559
                   ++  + Q   +HD  +      +EL+   + +K +   IEE L R K  L   
Sbjct: 1594 TLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEE-LQRQKEHLTQD 1652

Query: 560  IKDRDEE-------IQKLRNQLTNKTLSNSSQSE-----LENRLHQLTETLIQKQTMLES 607
            ++ RD+E       IQ L +Q T +T       E     L  R  +LT    Q+Q M E 
Sbjct: 1653 LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELT---TQRQLMQER 1709

Query: 608  LSTEKNSLVFQLERLE 623
                K     Q   LE
Sbjct: 1710 AEEGKGPSKAQRGSLE 1725



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 87/436 (19%), Positives = 192/436 (44%), Gaps = 49/436 (11%)

Query: 223  ELSNLRLENQLLRNEVQSLNQE---MASLLQRSKETQEELNKARA----RVEKWNADHSK 275
            +LS  R + +    +++ L+QE      +L R+ + +E L + +A    R++    D   
Sbjct: 695  KLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQD 754

Query: 276  SDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSE----KSR 331
                 +GL +  + L  ++     Q +V++V   + +  + T T+A E +Q E    K  
Sbjct: 755  LAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE 814

Query: 332  IMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKV-EMERQNLA 390
            +  ++S+    ++ A +   +   E    L++++ ++++  ++   +  K     +Q LA
Sbjct: 815  LDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELA 874

Query: 391  EAITLAERKYSDEKKRVDELQQQVKLYKLNLESSK--------QELIDYKQKATRILQSK 442
            +A+   ER+  + + R+ E Q +++  +   E  +        Q  ++ +++   +L   
Sbjct: 875  KALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLL--- 931

Query: 443  EKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQ 502
            E L+ + KE            +S +LE LR + ++Q+ + Q+  G    L+++LQ+ + +
Sbjct: 932  ETLLQTQKE---------LADASQQLERLRQDMKVQKLKEQETTG---ILQTQLQEAQRE 979

Query: 503  QVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKD 562
                A   R+ L  L ++ +     K +L+ ++E LK +    ++     +  +Q ++++
Sbjct: 980  LKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039

Query: 563  RDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERL 622
              E               N  Q ELE     LT +L++K+  L  L    +    +L  L
Sbjct: 1040 TQE--------------YNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSAL 1085

Query: 623  EQQMNSASGSSSNGSS 638
             Q M  A G     S+
Sbjct: 1086 RQDMQEAQGEQKELSA 1101



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 95/442 (21%), Positives = 195/442 (44%), Gaps = 43/442 (9%)

Query: 217  DDGKSHELSNLRLENQLLRNE--VQSLNQEMASLLQRSKETQEELNKARARVEKWNADHS 274
            +  + HE+    L++  L+ +  ++  +QE+ +L   S+ ++ +   ARAR E       
Sbjct: 1912 EQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALG 1971

Query: 275  KSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQ 334
            K+    +G    + +  E   + ++  A L+  L +A Q  S + E  EAL+ ++  I Q
Sbjct: 1972 KAHAALQGKEQHLLEQAELSRSLEASTATLQASL-DACQAHSRQLE--EALRIQEGEI-Q 2027

Query: 335  DQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNK-VEMERQNLAEAI 393
            DQ   +    + +Q  Q+ L + D  L+ +QE  + ++   A R+ + +  E+QNL +  
Sbjct: 2028 DQ---DLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQ-- 2082

Query: 394  TLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGS 453
               ER    E++ +  L Q V+  +L L   +QE+++ ++   R   + E L +S K   
Sbjct: 2083 ---ER----EEEEIRGLHQSVRELQLTLAQKEQEILELRETQQR--NNLEALPHSHKTSP 2133

Query: 454  GFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIH----QLRSELQDME---AQQVNE 506
              E        S++L+ L    + + E +Q  + Q      + R + QD+    AQ    
Sbjct: 2134 MEE-------QSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKAS 2186

Query: 507  AESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDE- 565
              S +E    L   +  + + +Q L+ ELE  ++     +E L+    T  + +  R E 
Sbjct: 2187 VSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE--KERLHSPGATSTAELGSRGEQ 2244

Query: 566  -----EIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLE 620
                 E+  +  + +   +   S  +    L Q    L   ++ L+  + +  S + Q+E
Sbjct: 2245 GVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE 2304

Query: 621  RLEQQMNSASGSSSNGSSINMS 642
            R  +++   +  ++   S+ +S
Sbjct: 2305 RERRKLKREAMRAAQAGSLEIS 2326



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 114/517 (22%), Positives = 219/517 (42%), Gaps = 82/517 (15%)

Query: 235 RNEVQSLNQEMA------SLLQRSKETQEELNKA-RARVEKWNADHSKSDRMTRGLRAQV 287
           R  VQ L Q++A      +LLQ+  +  EE  KA R R++K   +       T  L+ +V
Sbjct: 399 RQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEV 458

Query: 288 DDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRI-MQDQSEGNSLQNQA 346
           D L     +K+ +L      LQ+A + L  + E LE       R+ ++ Q +G+S Q Q 
Sbjct: 459 DSL-----SKEREL------LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQK 507

Query: 347 LQTFQERLH-------------------------------EADATLKREQESYKQMQSEF 375
            +  QE LH                               EA  +   E E  +Q Q+E 
Sbjct: 508 -EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEV 566

Query: 376 AARLNKVEMERQNLAEAITLAERKYSDEKK---RVDELQQQVKLYKLNLESSKQELIDYK 432
            A L + E     L+ +    + + +D +    ++  L + + L K+ L     +L +  
Sbjct: 567 TAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEEN 626

Query: 433 QKATRILQSKEKLINSLKE--GSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIH 490
           Q     +++ E+  N+L+       +  ++    +  LE    + E    E+Q  +  I 
Sbjct: 627 QSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQ 686

Query: 491 QLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLY 550
           + + E+Q   ++  ++ E+A  QL+ LH     Q+A +Q  E  L R  QE    +E L 
Sbjct: 687 EEKEEIQKKLSESRHQQEAATTQLEQLH-----QEAKRQ--EEVLARAVQE----KEALV 735

Query: 551 RTKNTLQSRI----KDRDEEIQKLRNQLTNKTLSNSS--QSELENRLHQLTETLIQKQTM 604
           R K  L+ R+    +DR +  ++L+   + K L  SS  +++ +N + ++T+  ++ Q  
Sbjct: 736 REKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQ 795

Query: 605 L-----ESLSTEKNSLVFQLE----RLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNV 655
                 E +  E   L  +L+    + EQ+ ++A+   +       + ++  +    + V
Sbjct: 796 TVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEV 855

Query: 656 PVLFNDTETNLAGMYGKVRKAASSIDQFSIRLGIFLR 692
             L    E   +    ++ KA  S+++  + L + L+
Sbjct: 856 NQLREKWEKERSWHQQELAKALESLEREKMELEMRLK 892



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 72/407 (17%), Positives = 163/407 (40%), Gaps = 22/407 (5%)

Query: 235  RNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAV 294
            R+++ +L +E +SLLQ   + Q+++   ++++   +      ++  +    +  +     
Sbjct: 988  RDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQ 1047

Query: 295  AAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERL 354
               + + A L + L E +Q L    EA    Q E S + QD  E    Q + L    E L
Sbjct: 1048 KELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE-LSAQMELL 1106

Query: 355  HEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQV 414
             +    +K ++  +   +++    L    +  Q L  ++   E K +  + R+   + Q+
Sbjct: 1107 RQE---VKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQL 1163

Query: 415  KLYKLNLESSKQELID---------YKQKATRILQSKEKLINSLKEGSGFEGLDSSTASS 465
            +      +   Q              +Q    + +S+ +L           GL+     +
Sbjct: 1164 EALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGA 1223

Query: 466  MELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQK 525
              L   +    +     + +   +H+L  +L   + QQ  +    R+Q+Q L +++   +
Sbjct: 1224 RSL--FKRGPLLTALSAEAVASALHKLHQDL--WKTQQTRDV--LRDQVQKLEERLTDTE 1277

Query: 526  ASKQELETELERLKQEFHYIEEDLYR---TKNTLQSRIKDRDEEIQKLRNQLTNKTLSNS 582
            A K ++ TEL+ L+++    +E+  +    +N+L+S + +  E +  L+++L    L   
Sbjct: 1278 AEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM 1337

Query: 583  SQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSA 629
                    L    E L  +   L++   E  +       LE+ + +A
Sbjct: 1338 EAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTA 1384



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 96/409 (23%), Positives = 174/409 (42%), Gaps = 44/409 (10%)

Query: 220  KSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRM 279
            +S ++ +L   + +L  E+Q  +QE+ S     +E  EEL + +  + + + +    + M
Sbjct: 1607 QSSQIHDLESHSTVLARELQERDQEVKS----QREQIEELQRQKEHLTQ-DLERRDQELM 1661

Query: 280  TRGLRAQV--DDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSE---KSRIMQ 334
             +  R QV  D  T      +  L  +K+ L+E  + L+T+ + ++    E    S+  +
Sbjct: 1662 LQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQR 1721

Query: 335  DQSEGNSL----QNQALQTFQERLHEADAT---LKREQESYKQMQSEFAARLNKVEME-- 385
               E   L    + + ++  QE +HE       L+++ +   +   E +  L++ E E  
Sbjct: 1722 GSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIV 1781

Query: 386  --RQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELID-------YKQKAT 436
              +Q L EA    E K    + ++DE Q+ +      LE+ +QE           K+KA 
Sbjct: 1782 VLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKAD 1841

Query: 437  RILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSEL 496
             +  + E+   +LKE  G   L      +  LEE   E  ++   +Q L   +  LR+E 
Sbjct: 1842 ALQGALEQAHMTLKERHG--ELQDHKEQARRLEE---ELAVEGRRVQALEEVLGDLRAES 1896

Query: 497  QDME----AQQVNEAESARE---QLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDL 549
            ++ E    A Q   AE A+E   + + L D     +A  +E + ELE L+ E     +  
Sbjct: 1897 REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAE----SQSS 1952

Query: 550  YRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETL 598
               +   ++R +   E + K    L  K      Q+EL   L   T TL
Sbjct: 1953 RHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 88/419 (21%), Positives = 178/419 (42%), Gaps = 34/419 (8%)

Query: 234 LRNEVQSLNQEMASLLQRSKETQ----EELNKARARVEKWNADHSKSDRMTRGLRA-QVD 288
           L+ EV SL++E   LLQ+++E      E L +   R+ + N +        +G +  Q +
Sbjct: 454 LQGEVDSLSKER-ELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQE 512

Query: 289 DLTEAVAAKD---SQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQ 345
           +L  AV  ++     L  L+ +  E+   L T  EALE+   E   + Q+Q+E  +   +
Sbjct: 513 ELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALAR 572

Query: 346 ALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKK 405
           A Q+  E L  ++ TLK E    +    + +A    + +++  L + +   E +      
Sbjct: 573 AEQSIAE-LSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS 631

Query: 406 RVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFE---GLDSST 462
           R++  +Q     +++L  +++      +K T +    +K      E +G E    L    
Sbjct: 632 RMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKA-----EEAGAELQADLRDIQ 686

Query: 463 ASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIA 522
               E+++   E   Q+E     + Q+HQ     +++ A+ V E E+   +   L  ++ 
Sbjct: 687 EEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQ 746

Query: 523 GQKASKQELETELERLKQEFHYIEEDLYR----------TKNTLQSRIKDRDEEIQKLRN 572
             +  +Q+L  +L+ L      +E  L+           TK  L+ +I+   +  + ++ 
Sbjct: 747 AVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQG 806

Query: 573 Q-----LTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQL-ERLEQQ 625
           +     L   T  + ++ E +    QL +   + +T LE         V QL E+ E++
Sbjct: 807 EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKE 865



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 75/391 (19%), Positives = 160/391 (40%), Gaps = 53/391 (13%)

Query: 266  VEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALE-- 323
            + K + D  K+ +    LR QV  L E +   +++ + +   LQ+  + LS   E     
Sbjct: 1245 LHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKW 1304

Query: 324  -----ALQSEKSRI------MQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQ 372
                 +L+SE   +      +Q +     LQ    Q  +E L  A   L  + E  +   
Sbjct: 1305 EGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAV 1364

Query: 373  SEFAARLNK---VEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELI 429
             E  A+ +    +E + +    A+ L   +   E++R   LQ+Q +L     ++ ++ L 
Sbjct: 1365 VEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLA 1424

Query: 430  DYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQI 489
                  T+ L  +E+ + +L+                +++EL  ++EMQ+  ++ L   +
Sbjct: 1425 ----LLTQTLAEREEEVETLRG---------------QIQELEKQREMQKAALELLSLDL 1465

Query: 490  HQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDL 549
             +   E+ D++ +Q+ E E  R  L+ L   +       QE E +L   +++   +E+D 
Sbjct: 1466 KKRNQEV-DLQQEQIQELEKCRSVLEHLPMAV-------QEREQKLTVQREQIRELEKDR 1517

Query: 550  YRTKNTLQSRIKDRDE----------EIQKLRNQLTNKTLSNSSQSELENRLHQLTETLI 599
               +N L+ ++ + ++          ++Q L+ QL           E  +++    + + 
Sbjct: 1518 ETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIK 1577

Query: 600  QKQTMLESLSTEKNSLVFQLERLEQQMNSAS 630
            + +   E+       L   LE   Q++ + S
Sbjct: 1578 ELEGQRETQRVALTHLTLDLEERSQELQAQS 1608



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 106/467 (22%), Positives = 184/467 (39%), Gaps = 57/467 (12%)

Query: 179  QTHEAASNSDSSHEGQEESSKENVSSNA-------ACPDHTPTPNDDGKSHELSNLRLEN 231
            + H A    +     Q E S+   +S A       AC  H+    +  +  E   ++ ++
Sbjct: 1972 KAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQE-GEIQDQD 2030

Query: 232  QLLRNEVQSLNQEMASL---LQRSKETQEELNKARAR-------VEKWNADHSKSDRMTR 281
               + +VQ L Q +A     L+  +E ++ L K+ A+        EK N    + +   R
Sbjct: 2031 LRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIR 2090

Query: 282  GLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEAL-QSEKSRIMQDQSEGN 340
            GL   V +L   +A K+ ++  L+   Q  +         LEAL  S K+  M++QS   
Sbjct: 2091 GLHQSVRELQLTLAQKEQEILELRETQQRNN---------LEALPHSHKTSPMEEQSLKL 2141

Query: 341  SLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKY 400
                  LQ   ERL  A    +  +  +++   + A  L + +    +L E     +   
Sbjct: 2142 DSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASV 2201

Query: 401  SDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDS 460
             +       LQ +++L +  LE  K+ L      +T  L S+ +    L E SG E   S
Sbjct: 2202 LERDSEQQRLQDELELTRRALE--KERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPS 2259

Query: 461  STASSME--LEELRH-EKEMQREEIQKLMGQIH--QLRSELQDMEAQQVNEAESAREQLQ 515
                  +   + L H ++ + R EI +   Q H  QLRS L+ +E ++      A    Q
Sbjct: 2260 PDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQ 2319

Query: 516  DLHDQIA-------------GQKASKQELETELERLKQEFHYIEEDL---YRTKNTLQSR 559
                +I+             GQK S  +   EL++   E   ++  L    + K    +R
Sbjct: 2320 AGSLEISKATASSPTQQDGRGQKNSDAKCVAELQK---EVVLLQAQLTLERKQKQDYITR 2376

Query: 560  IKDRDEEIQKLRNQLTNKTLSNSSQSE---LENRLHQLTETLIQKQT 603
                  E+  L + L++  L+ +   E   LE    +L E+L Q  T
Sbjct: 2377 SAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLT 2423



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 75/337 (22%), Positives = 152/337 (45%), Gaps = 53/337 (15%)

Query: 314 LLSTRTEALEALQSEKSR-IMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQ 372
           LL  +T+ LE    E+S+ ++Q +S+G+ L+   L   Q+R+ E  A L + Q+  +  +
Sbjct: 248 LLLAKTQELEKEAHERSQELIQLKSQGD-LEKAEL---QDRVTELSALLTQSQKQNEDYE 303

Query: 373 SEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYK 432
               A           L E + + E  +++  +    L +  +  KL+L+   +++    
Sbjct: 304 KMIKA-----------LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDI---- 348

Query: 433 QKATRILQSKEKLINSLKEGSGFEG---LDSSTASSMELEE-------LRHEKEMQREEI 482
              T+++  +    +++ +GSG E    LDSS  S  + ++       +R     +R+ +
Sbjct: 349 ---TQVMVEEG---DNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAV 402

Query: 483 QKLMGQI---HQLRSELQDMEAQQVNEAESAREQLQDL---HDQIAGQKASKQELETELE 536
           Q L  Q+    +  + LQ    Q   E ++ R++LQ L    D +AGQ     +L+ E++
Sbjct: 403 QDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTV---DLQGEVD 459

Query: 537 RLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSS----QSELENRLH 592
            L +E     E L + +  L+ +++  ++E  +LR       L   S    + E +  LH
Sbjct: 460 SLSKE----RELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELH 515

Query: 593 QLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSA 629
                  + Q ML  L  +++  + +L  L + + S+
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESS 552



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 86/362 (23%), Positives = 154/362 (42%), Gaps = 28/362 (7%)

Query: 212 TPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASL--LQRSKETQEE----LNKARAR 265
           T +P  +    +   L LE Q+L  + Q    + AS   L+ S+E Q+     + K +A+
Sbjct: 3   TRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAK 62

Query: 266 VEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEAL 325
           V ++ +   + ++        +    E V  ++  L  L VRL+E  Q    R E+L  +
Sbjct: 63  VLQYRSWCQELEKRLEATGGPIPQRWENV--EEPNLDELLVRLEEEQQ----RCESLAEV 116

Query: 326 QSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQ----ESYKQMQSEFAARLNK 381
            ++    ++   E   + N+AL+   E+L   D +  R++    ES  QM+ EF     K
Sbjct: 117 NTQ----LRLHMEKADVVNKALREDVEKL-TVDWSRARDELMRKESQWQMEQEFFKGYLK 171

Query: 382 VEMERQ-NLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQ 440
            E  R  +L   +    R + + K   D    ++K   + L  S   L+    + T   Q
Sbjct: 172 GEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGS---LLTCCLRLTVGAQ 228

Query: 441 SKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDME 500
           S+E   +   +G     L    A + ELE+  HE+    +E+ +L  Q    ++ELQD  
Sbjct: 229 SREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERS---QELIQLKSQGDLEKAELQDRV 285

Query: 501 AQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRI 560
            +       +++Q +D    I   + + + LET    L +    +  +    K +LQ  I
Sbjct: 286 TELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVI 345

Query: 561 KD 562
           KD
Sbjct: 346 KD 347


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 97/419 (23%), Positives = 192/419 (45%), Gaps = 47/419 (11%)

Query: 243  QEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLA 302
            +EMA++ +  ++T+EEL K  A+         + +     L  + +DL   V A+   LA
Sbjct: 851  KEMANMKEEFEKTKEELAKTEAK-------RKELEEKMVTLMQEKNDLQLQVQAEADALA 903

Query: 303  VLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLK 362
              + R    DQL+ T+ + LEA   E +   +D+ E N+     L   + +L +  + LK
Sbjct: 904  DAEER---CDQLIKTKIQ-LEAKIKEVTERAEDEEEINA----ELTAKKRKLEDECSELK 955

Query: 363  REQESYKQMQSEFAARLNKVEMERQNLAEAITLAER---KYSDEKKRVDELQQQVKLYKL 419
            ++ +  +   ++     +  E + +NL E +   +    K + EKK + E  QQ  L  L
Sbjct: 956  KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT-LDDL 1014

Query: 420  NLESSKQELIDYKQKATRILQSKEKLINSLKEGS-----------GFEG-LDSSTASSME 467
             +E  K   +   +  T++ Q  + L  SL++               EG L  +  S+M+
Sbjct: 1015 QMEEDKVNTL--TKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMD 1072

Query: 468  LEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESARE---QLQDLHDQIAGQ 524
             E   ++K+   E+++K   ++  L+ +++D +A  +   +  +E   ++++L ++I  +
Sbjct: 1073 TE---NDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAE 1129

Query: 525  KASKQELETELERLKQEFHYIEEDLYRTKNTLQSRI---KDRDEEIQKLRNQLTNKTLSN 581
            +AS+ + E +   L +E   I E L        ++I   K R+ E QK+R  L   TL +
Sbjct: 1130 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQH 1189

Query: 582  SSQSELENRLH-----QLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSN 635
             + +    + H     +L E +   Q + + L  EK+ L  ++  L   M + S + +N
Sbjct: 1190 EATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKAN 1248



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 107/543 (19%), Positives = 211/543 (38%), Gaps = 143/543 (26%)

Query: 192  EGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQL----------------LR 235
            E  EE+ K+         +H    N    S E +  RL+N++                L 
Sbjct: 1388 EELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALD 1447

Query: 236  NEVQSLNQEMASLLQRSKETQEELNKARARVEKWNA-------------DHSKS-DRMTR 281
             + ++ ++ +A   Q+ +ETQ EL  ++      +              DH ++  R  +
Sbjct: 1448 KKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENK 1507

Query: 282  GLRAQVDDLTEAVAAKDSQLAVL-KVRLQ---EADQLLSTRTEALEALQSEKSRIMQDQS 337
             L+ ++ DLTE +A     +  L KV+ Q   E  +L ++  EA  +L+ E+ +I++ Q 
Sbjct: 1508 NLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQL 1567

Query: 338  EGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAAR-----------------LN 380
            E N ++++  +   E+  E D   +      + MQS   A                  LN
Sbjct: 1568 ELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLN 1627

Query: 381  KVEME-----------------------------------RQNLAEAITLAERKYSDEKK 405
            ++E++                                   + +L E + + ER+ +  + 
Sbjct: 1628 EMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQA 1687

Query: 406  RVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASS 465
             V+EL+  ++  +   + ++QEL+D  ++   +      LIN+ K               
Sbjct: 1688 EVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKK--------------- 1732

Query: 466  MELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQK 525
                              KL   I Q++ E++D+  +  N  E A++ + D    +A + 
Sbjct: 1733 ------------------KLETDISQIQGEMEDIVQEARNAEEKAKKAITDA-AMMAEEL 1773

Query: 526  ASKQELETELERLKQEFHYIEEDL-YRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQ 584
              +Q+    LER+K+      +DL  R     Q  +K   ++IQKL  ++  + L +  +
Sbjct: 1774 KKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARV--RELESEVE 1831

Query: 585  SEL-------------ENRLHQLT-------ETLIQKQTMLESLSTEKNSLVFQLERLEQ 624
            SE              E R+ +LT       + +++ Q +++ L T+  +   Q E  E+
Sbjct: 1832 SEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEE 1891

Query: 625  QMN 627
            Q N
Sbjct: 1892 QSN 1894



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 91/411 (22%), Positives = 175/411 (42%), Gaps = 62/411 (15%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEA 293
            L  ++ SL +    L +   E + E+N   + +E  +   +  ++M R L          
Sbjct: 1207 LGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTL---------- 1256

Query: 294  VAAKDSQLAVLKVRLQEADQL---LSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTF 350
                + QL+ +K + +E  +L   LS +   L     E SR + ++    S  ++  Q F
Sbjct: 1257 ----EDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAF 1312

Query: 351  QERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDEL 410
             +++ E    LKR+ E   + +S  A  L       Q+      L   +Y +E++   EL
Sbjct: 1313 TQQIEE----LKRQLEEETKAKSTLAHAL-------QSARHDCDLLREQYEEEQEAKAEL 1361

Query: 411  QQQVKLYKLNLESSKQEL---IDYKQKATRILQSKEKLINSLKEG-SGFEGLDSSTASSM 466
            Q+ +   K N E ++       D  Q+   + ++K+KL   L++     E ++S  AS  
Sbjct: 1362 QRGMS--KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCAS-- 1417

Query: 467  ELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKA 526
                L   K+  + E++ LM  + +  +    ++ +Q N  +   E  Q   +  A  +A
Sbjct: 1418 ----LEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEA 1473

Query: 527  SKQE---LETELERLKQEFHYI---EEDLYRTKNTLQSRIKDRDE----------EIQKL 570
            S++E   L TEL ++K  +       E L R    LQ  I D  E          E++K+
Sbjct: 1474 SQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKV 1533

Query: 571  RNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLER 621
            + QL ++      +SEL+  L +   +L  ++  +  +  E N +  +++R
Sbjct: 1534 KKQLDHE------KSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDR 1578



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 103/529 (19%), Positives = 209/529 (39%), Gaps = 47/529 (8%)

Query: 127  LNSSQKEPTGRVEIRKE-----KGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTH 181
            L +  KE T R E  +E       K    +   +     ++    T+  +E+      T 
Sbjct: 919  LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA--TE 976

Query: 182  EAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHE--LSNLRLENQLLRNEVQ 239
                N      G +E+  +      A  +      DD +  E  ++ L      L  +V 
Sbjct: 977  NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVD 1036

Query: 240  SLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDS 299
             L       L++ K+   +L +A+ ++E    D   +   T         L E +  K+ 
Sbjct: 1037 DLEGS----LEQEKKLCMDLERAKRKLE---GDLKLAQESTMDTENDKQQLNEKLKKKEF 1089

Query: 300  QLA----------VLKVRLQEADQLLSTRTEALEA-LQSEKSRIMQDQSEGNSLQNQALQ 348
            +++           L ++LQ+  + L  R E LE  +++E++   + + + + L  + L+
Sbjct: 1090 EMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE-LE 1148

Query: 349  TFQERLHEADATLKREQESYKQMQSEF-AARLNKVEMERQNLAEAITLAERKYSDEKKRV 407
               ERL EA      + E  K+ ++EF   R +  E   Q+ A A  L  +K++D    +
Sbjct: 1149 EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAAL-RKKHADSVAEL 1207

Query: 408  DELQQQVKLYKLNLESSKQEL----IDYKQKATRILQSK---EKLINSLKEGSGFEGLDS 460
             E    ++  K  LE  K EL     D       + ++K   EK+  +L+     + L  
Sbjct: 1208 GEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLE-----DQLSE 1262

Query: 461  STASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQ 520
                  E + L +E   Q+  +    G+  +   E   M +Q     ++  +Q+++L  Q
Sbjct: 1263 IKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQ 1322

Query: 521  IAGQKASKQELETELERLKQEFHYIE---EDLYRTKNTLQSRIKDRDEEIQKLRNQLTNK 577
            +  +  +K  L   L+  + +   +    E+    K  LQ  +   + E+ + R +    
Sbjct: 1323 LEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETD 1382

Query: 578  TLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQM 626
             +  +   ELE    +L + L   +  +E+++++  SL    +RL+ ++
Sbjct: 1383 AIQRT--EELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEV 1429



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 76/357 (21%), Positives = 160/357 (44%), Gaps = 46/357 (12%)

Query: 295  AAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERL 354
            A  + ++A +K   ++  + L+      + L+ +   +MQ++   N LQ Q +Q   + L
Sbjct: 847  AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEK---NDLQLQ-VQAEADAL 902

Query: 355  HEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQV 414
             +A+    +  ++  Q++++      + E E +  AE +T  +RK  DE     EL++ +
Sbjct: 903  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAE-LTAKKRKLEDE---CSELKKDI 958

Query: 415  KLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHE 474
               +L L   ++E             + E  + +L E     GLD + A      +L  E
Sbjct: 959  DDLELTLAKVEKEK-----------HATENKVKNLTEEMA--GLDETIA------KLTKE 999

Query: 475  KEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETE 534
            K        K + + HQ   +   ME  +VN    A+ +L+   D + G    +++L  +
Sbjct: 1000 K--------KALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMD 1051

Query: 535  LERLKQEFH----YIEEDLYRTKNT---LQSRIKDRDEEIQKLRNQLTNK-TLSNSSQS- 585
            LER K++        +E    T+N    L  ++K ++ E+  L+ ++ ++  L+   Q  
Sbjct: 1052 LERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKK 1111

Query: 586  --ELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSIN 640
              EL+ R+ +L E +  ++        +++ L  +LE + +++  A G++S    +N
Sbjct: 1112 IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1168



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 78/373 (20%), Positives = 154/373 (41%), Gaps = 53/373 (14%)

Query: 220  KSHELSNLRLENQLLRNEVQS-LNQEMAS---LLQRSKETQEELNKARARVEKWNADHSK 275
            K  EL  L+  +  +   +QS L+ E+ S    L+  K+ + +LN+   ++   N   ++
Sbjct: 1583 KDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAE 1642

Query: 276  SDRMTRGLRAQVDD----LTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSR 331
            + R  R  +  + D    L +A+  +D         L+E   ++  R   ++A   E   
Sbjct: 1643 ALRNLRNTQGILKDTQLHLDDAIRGQDD--------LKEQLAMVERRANLMQAEVEELRA 1694

Query: 332  IMQDQSEGNSLQNQALQTFQER---LHEADATL----KREQESYKQMQSEFAARLNKVEM 384
             ++    G  +  Q L    ER   LH  + +L    K+ +    Q+Q E    + +   
Sbjct: 1695 SLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARN 1754

Query: 385  ERQNLAEAITLAERKYSDEKKRVD----------ELQQQVKLYKLNLESSKQELIDYKQK 434
              +   +AIT A     + KK  D           ++Q VK  +L L+ ++Q  +   +K
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1814

Query: 435  ATRILQSKEKLINSLKEGS---GFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQ 491
              + L+++ + + S  E       E +         ++EL ++ E  R+ I +L   + +
Sbjct: 1815 QIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1874

Query: 492  LRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYR 551
            L+++++  + Q    AE A EQ            A  ++L+ ELE  K+     E  + +
Sbjct: 1875 LQTKVKAYKRQ----AEEAEEQSNV-------NLAKFRKLQHELEEAKERADIAESQVNK 1923

Query: 552  TKNTLQSRIKDRD 564
                   R+K R+
Sbjct: 1924 L------RVKSRE 1930



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 40/202 (19%), Positives = 88/202 (43%), Gaps = 21/202 (10%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKA-------RARVEKWNADHSKSDRMTRGLRAQ 286
            L  ++  +  EM  ++Q ++  +E+  KA          ++K     +  +RM + +   
Sbjct: 1734 LETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1793

Query: 287  VDDL------TEAVAAKDS--QLAVLKVRLQEADQLLSTR----TEALEALQSEKSRIMQ 334
            V DL       E +A K    Q+  L+ R++E +  + +      EA++ L+  + R+ +
Sbjct: 1794 VKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKE 1853

Query: 335  --DQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEA 392
               Q+E +      LQ   ++L       KR+ E  ++  +   A+  K++ E +   E 
Sbjct: 1854 LTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKER 1913

Query: 393  ITLAERKYSDEKKRVDELQQQV 414
              +AE + +  + +  E+  +V
Sbjct: 1914 ADIAESQVNKLRVKSREVHTKV 1935



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 60/274 (21%), Positives = 114/274 (41%), Gaps = 35/274 (12%)

Query: 383  EMERQNLAEAITLAE------------RKYSDEKKRVDELQQQVKLYKLNLESSKQELID 430
            EM  + LA+ IT  +            RK  + ++ +  +Q  ++ + +N++      + 
Sbjct: 779  EMRDEKLAQLITRTQAICRGFLMRVEFRKMMERRESIFCIQYNIRAF-MNVKHWPWMKLY 837

Query: 431  YKQKATRILQSKEKLINSLKEG--SGFEGLDSSTASSMELEE----LRHEKEMQREEIQK 484
            +K K        EK + ++KE      E L  + A   ELEE    L  EK   + ++Q 
Sbjct: 838  FKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQA 897

Query: 485  ---LMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQE 541
                +    +   +L   + Q   + +   E+ +D  +  A   A K++LE E   LK++
Sbjct: 898  EADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 957

Query: 542  FHYIEEDLYRT---KNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETL 598
               +E  L +    K+  ++++K+  EE+  L   +   T    +  E     HQ T   
Sbjct: 958  IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA----HQQTLDD 1013

Query: 599  IQKQTMLESLSTEKNSLVFQLERLEQQMNSASGS 632
            +Q +        + N+L     +LEQQ++   GS
Sbjct: 1014 LQME------EDKVNTLTKAKTKLEQQVDDLEGS 1041


>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 98/426 (23%), Positives = 202/426 (47%), Gaps = 44/426 (10%)

Query: 234 LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEA 293
           L +EV +L Q    L +   + Q  L    A +   N D   ++   + L A+V+D+  +
Sbjct: 466 LSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRS 525

Query: 294 VAAKDS-------QLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQA 346
           + +KD+       Q+  L+ +LQ+     +T T  L+A Q+E S          SLQ+  
Sbjct: 526 MLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEIS----------SLQS-V 574

Query: 347 LQTFQERL---HEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDE 403
            Q +Q++L    EA   L+ E    +  Q   A  L  +++E  +L++ +T  + +   E
Sbjct: 575 RQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKE 634

Query: 404 KKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTA 463
           K R+    Q ++   L+ E++  ++ + K      LQ + +     +E       DS+ +
Sbjct: 635 KGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQ-RMADSAAS 693

Query: 464 SSMELEELR---HEKEMQREEIQK----LMGQIHQLRSELQDMEAQQVNEAESAREQLQD 516
              +LE+++    +++ Q E +Q+    LM Q+   +  LQ  E Q ++  ++  ++LQ 
Sbjct: 694 LEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSRE-QSLDALQTHYDELQA 752

Query: 517 LHDQIAGQKASKQE----LETE---LERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQK 569
              ++ G+ AS+++    L+ E   LE   Q     +E+L R    L+   ++  E ++K
Sbjct: 753 RLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEK 812

Query: 570 LRNQLTNKTLS----NSSQSELENRLHQLTETLIQKQTMLESL---STEKNSLVFQLERL 622
           LR +L  K+          + L+ ++ ++ E  +Q++ M+E+    +T K+ L+ +L+  
Sbjct: 813 LREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKAT 872

Query: 623 EQQMNS 628
            ++++S
Sbjct: 873 RKRLDS 878



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 101/425 (23%), Positives = 185/425 (43%), Gaps = 39/425 (9%)

Query: 231  NQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDL 290
            N+ L+ +++ L QE    +   K+    L       +K      K+     G+ ++   L
Sbjct: 953  NEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSR--RL 1010

Query: 291  TEAVAAK---DSQLAVLKVRLQEADQLLST--RTEALEA----LQSEKSRIMQDQSEGNS 341
             EA+AAK   D++L  L+ +   +D  L+   R +ALEA    +   K+ + ++  E  +
Sbjct: 1011 QEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIA 1070

Query: 342  LQNQALQTFQERLHEADATL----------KREQESYKQMQSEFA---ARLNKVEMERQN 388
            L +Q L+  +E++ E +  L          KR +ES K++  E      +L  +      
Sbjct: 1071 LTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAA 1130

Query: 389  LAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINS 448
            L E  ++ E   +  +  + +L  QV+      E   +++    Q     L+ +++ +NS
Sbjct: 1131 LREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNS 1190

Query: 449  LKEGSGFEGLDSS------TASSMELEELRHEKEMQREEIQKLMGQIH--QLRSELQDME 500
            LKE      +++        A+S+EL E++ E + +   +QKL  +    Q+R      E
Sbjct: 1191 LKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQE 1250

Query: 501  AQQVN-EAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSR 559
              Q   E   AR QLQ L  Q+  Q + +     E+E LK E    E ++   K  L   
Sbjct: 1251 IAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLT 1310

Query: 560  IKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQL 619
             +   +E++ L+  L N       +SELE     L+ T   K  +   +S  KN++   L
Sbjct: 1311 EQQGRKELEGLQQLLQN------VKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLL 1364

Query: 620  ERLEQ 624
            ++ +Q
Sbjct: 1365 QQNQQ 1369



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 92/460 (20%), Positives = 216/460 (46%), Gaps = 52/460 (11%)

Query: 223  ELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEEL---NKARARVEKWNADHSKSDRM 279
            +L  ++LE   L +++++   E++SL    +  Q++L    +AR R++   A H +  +M
Sbjct: 546  QLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMA-HIQVGQM 604

Query: 280  TR-GL--RAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEA----LQSEKSRI 332
            T+ GL    ++++++ +    ++Q   +K + + A QL     + L+     +Q ++++ 
Sbjct: 605  TQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKT 664

Query: 333  MQDQSEGNSLQN-QALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAE 391
            M ++     L+  +  +   +R+ ++ A+L+++ E  K    +   +L  ++ E  +L +
Sbjct: 665  MVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMK 724

Query: 392  AITLAERKYSDEKKRVDELQQ-----QVKLYKLNLES-SKQELIDYKQKATRILQSKEKL 445
             +TL +      ++ +D LQ      Q +L +L  E+ S+++ I   Q    IL++  + 
Sbjct: 725  QLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQA 784

Query: 446  INSLKE--GSGFEGLDSSTASSME-LEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQ 502
              S KE    G   L+  T  + E LE+LR E  ++  +++ L  +   L+ ++Q ++ Q
Sbjct: 785  AKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQ 844

Query: 503  --------------------QVNEAESARE----QLQDLHDQIAGQKASKQELETELERL 538
                                 ++E ++ R+    +L++L  ++      K+  E EL RL
Sbjct: 845  FLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRL 904

Query: 539  KQEFHYIEEDLYRTKNTLQSRIKDRDE------EIQKLRNQLTNKTLSNSS-QSELENRL 591
             +E   + + +   +  LQS  K+RDE       +Q  + Q+   T +N + + ++E   
Sbjct: 905  HREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQ 964

Query: 592  HQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASG 631
             +  + + +++  +  L ++  S   +++   +   +A G
Sbjct: 965  QEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVG 1004



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 103/509 (20%), Positives = 207/509 (40%), Gaps = 109/509 (21%)

Query: 221  SHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMT 280
            S  L  LR E  +   +V+ L QE A+L ++ ++ +E+  + +  VE +  D +  D++ 
Sbjct: 807  SETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLI 866

Query: 281  RGLRA----------------------------QVDDLTEAVAAKDSQLAVLKVRLQEA- 311
              L+A                            ++  L   VA     +A L+  LQ A 
Sbjct: 867  SELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQ 926

Query: 312  -----------------DQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERL 354
                             +Q+++  TEA EAL+ +   + Q+  +  + Q Q ++     L
Sbjct: 927  KERDEMETHLQSLQFDKEQMVAV-TEANEALKKQIEELQQEARKAITEQKQKMRRLGSDL 985

Query: 355  HEADATLKREQESY--------KQMQSEFAA--------------------------RLN 380
              A   +K + ++Y        +++Q   AA                          R+ 
Sbjct: 986  TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQ 1045

Query: 381  KVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQ 440
             +E E Q ++ + TL E++  +      +  ++ +   L LE   QE   +++K  R+ +
Sbjct: 1046 ALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEE 1105

Query: 441  SKEKLINSLKEGSG-FEGLDSSTASSMELEELRHEKEMQRE-EIQKLMGQIHQL--RSEL 496
            S +KL   L+   G   GL  S A+  E   +      +RE ++ +L  Q+  +  R E 
Sbjct: 1106 SNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEE 1165

Query: 497  QDMEAQQVNEA-----ESAREQLQDLHDQIAGQKASK-------QELETELERLKQEF-- 542
            +D + + + +A     E  +E++  L +Q+A  K          +    EL  +K+E   
Sbjct: 1166 EDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQA 1225

Query: 543  -HYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQK 601
              ++ + L    + LQ R     +EI + + +L        ++++L+    QL E L ++
Sbjct: 1226 KEHLVQKLQAEADDLQIREGKHSQEIAQFQAELA------EARAQLQLLQKQLDEQLSKQ 1279

Query: 602  ---QTMLESLSTEKNSLVFQLERLEQQMN 627
                  +E+L  E +    +++ L+QQ++
Sbjct: 1280 PVGNQEMENLKWEVDQKEREIQSLKQQLD 1308


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 89.7 bits (221), Expect = 8e-18
 Identities = 127/534 (23%), Positives = 245/534 (45%), Gaps = 69/534 (12%)

Query: 157 SVSSVNPSVTTIKTIEENSFG---SQTHEAASNSDSSHEGQ-EESSKENVSS-NAACPDH 211
           S+ S+   ++++   E + +    S++ +   +   SH G    S  ENV   + +  D 
Sbjct: 153 SLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDF 212

Query: 212 TPTPNDDGKS------HELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARAR 265
              P D   S       E+ +LR +   LR +   L  +  SL+ + +    EL ++RA+
Sbjct: 213 QKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAK 272

Query: 266 VEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEAL 325
           V    +   ++  +   L  Q+ +L   V+A+D  L   + +L+++ +++  + ++L+  
Sbjct: 273 VSMLESAQQQAASVPI-LEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQES 331

Query: 326 QSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEME 385
           + E  ++  D  E      +A +   E L+ A+   K    +++Q + + A +L KV+ E
Sbjct: 332 KEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSK----AFQQYKKKVAEKLEKVQAE 387

Query: 386 RQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKL 445
            + L   +T  E+    E KR   LQ++  LYK  LE  K++L   K++       KEKL
Sbjct: 388 EEILERNLTNCEK----ENKR---LQERCGLYKSELEILKEKLRQLKEENN---NGKEKL 437

Query: 446 -INSLKEGSGFEGLDSSTASSMELE-ELRHEKEMQREEIQKLMGQIHQLR------SELQ 497
            I ++K       L  S  S ++LE EL ++ E+ R++   LM +  +L+      +E  
Sbjct: 438 RIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKF-SLMNENRELKVRVAAQNERL 496

Query: 498 DMEAQQVNEAESAREQLQDLHDQIAGQKASKQEL---ETELERLKQEFHYIEEDL----- 549
           D+  Q++   ES+R +L+ L ++I  Q   K+EL   ++ L + +      +ED      
Sbjct: 497 DLCQQEI---ESSRVELRSL-EKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCC 552

Query: 550 ---YRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNS----SQSELENRL----------- 591
                  + L+ ++  ++ EIQKL   LT   LS S    + S+  ++L           
Sbjct: 553 EANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLG 612

Query: 592 -HQLTETL--IQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMS 642
            HQ+ E++    + TM +    E+  LV  +E L  ++      +S+   +NM+
Sbjct: 613 GHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSD-LKVNMA 665



 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 139/629 (22%), Positives = 248/629 (39%), Gaps = 95/629 (15%)

Query: 139  EIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEESS 198
            E+ ++   +   +S  T   S +   +T  K +EE    + +  AA N++   E  E++ 
Sbjct: 677  ELLEKASNSSKLESEMTKKCSQL---LTLEKQLEEKIV-AYSSIAAKNAELEQELMEKNE 732

Query: 199  KE-------NVSSNAACPDHTPTPN---DDGKSHELSNLRLENQLLRNEVQSLNQEMA-S 247
            K        N      C           +  K  E    RLE QL + + Q   QE   S
Sbjct: 733  KIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMS 792

Query: 248  LLQRS--------KETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDS 299
            +LQ+         +     L +++  ++K N    K D   + L+ QV + T  V   DS
Sbjct: 793  MLQQDIICKQHHLESLDRLLTESKGEMKKENM---KKDEALKALQNQVSEETIKVRQLDS 849

Query: 300  QLAVLKVRL-----------QEADQLLSTRTEALEALQSE---KSRIMQDQSEGNSLQNQ 345
             L + K  L           ++ ++ L  ++E +  LQ E   K+  +Q+ SE N +   
Sbjct: 850  ALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQH 909

Query: 346  ALQTFQERLHEADA---------------TLKREQESYKQMQSEFAARLNKVEMERQNLA 390
             LQ  Q+ L +                    K EQE  KQ +S  A +L K+E + ++ A
Sbjct: 910  TLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESS-AEKLRKMEEKCESAA 968

Query: 391  EAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQ----KATRILQ------ 440
                L  +K  +      +++ ++  YK  L   ++E++  K+    KA  + Q      
Sbjct: 969  HEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILD 1028

Query: 441  ----SKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSEL 496
                  EK  N++KE    E L  ST +  EL E   ++E+   E+Q   G++     +L
Sbjct: 1029 QTKTELEKKTNAVKE---LEKLQHSTET--ELTEALQKREVLETELQNAHGELKSTLRQL 1083

Query: 497  QDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKN-- 554
            Q++         S  E+   + D  A  +  K E+E + + L +    ++E  +  K   
Sbjct: 1084 QELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRA 1143

Query: 555  --------TLQSRIKDRDEEIQKLRNQLTNKTLS----NSSQSELENRLHQLTETLIQKQ 602
                    T++    + +++I KL   L    L     N     L ++L    E L +K+
Sbjct: 1144 AQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKE 1203

Query: 603  TMLESLSTEKNSLVFQLERLEQQMNSASGSSSNG----SSINMSGIDNGEGTRLRNVPVL 658
             ++     E + L  ++ER +Q+M              ++     ID G+  RL    V 
Sbjct: 1204 FIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQV- 1262

Query: 659  FNDTETNLAGMYGKVRKAASSIDQFSIRL 687
              ++ T LA    +  +A   I++ S  L
Sbjct: 1263 -QNSHTELAEARHQQVQAQREIERLSSEL 1290



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 74/366 (20%), Positives = 166/366 (45%), Gaps = 17/366 (4%)

Query: 223  ELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRG 282
            EL+    + ++L  E+Q+ + E+ S L++ +E ++ L KA+  +E+            R 
Sbjct: 1054 ELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRE 1113

Query: 283  LRAQVDDLTEAVAAKDSQLAV----LKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSE 338
             + +++D  + +   D  L      LK R  +   L  T  E    ++ +K   ++   E
Sbjct: 1114 CKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEME-QKIIKLEGTLE 1172

Query: 339  GNSLQ----NQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAIT 394
             + L+    N+ +++  ++L  A   L+ ++    Q + E +    ++E  +Q + E  +
Sbjct: 1173 KSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMES 1232

Query: 395  LA---ERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKE 451
            +    E+  + + K   +L Q+++L +  +++S  EL + + +  +  +  E+L + L++
Sbjct: 1233 VMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELED 1292

Query: 452  GSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAR 511
                     +  + +  EEL   K  +     ++  +I +L +E++ ++     E  S +
Sbjct: 1293 MKQLSKEKDAHGNHLA-EELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQ 1351

Query: 512  EQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLR 571
            E           QK+S Q+L  +LE+ K E     E+   T + L  +++DR+E I+   
Sbjct: 1352 ENHAKWKISADSQKSSVQQLNEQLEKAKLEL----EEAQDTVSNLHQQVQDRNEVIEAAN 1407

Query: 572  NQLTNK 577
              L  K
Sbjct: 1408 EALLTK 1413



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 86/430 (20%), Positives = 180/430 (41%), Gaps = 53/430 (12%)

Query: 224 LSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGL 283
           +S LR++  +   E+Q L+  +         T  +L+++             S   T  +
Sbjct: 559 ISELRIKLAIKEAEIQKLHANL---------TANQLSQSLITCNDSQESSKLSSLETEPV 609

Query: 284 RAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQ 343
           +     + E+V  KD     +  + ++  Q L T  E L      +++++Q ++E + L+
Sbjct: 610 KLGGHQVAESV--KDQNQHTMNKQYEKERQRLVTGIEEL------RTKLIQIEAENSDLK 661

Query: 344 -NQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAER---K 399
            N A +T Q +L + +   K    S  +++SE   + +++    + L E I        K
Sbjct: 662 VNMAHRTSQFQLIQEELLEKASNSS--KLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAK 719

Query: 400 YSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLD 459
            ++ ++ + E  ++++  + N+ +  +++    +KA +I   + K +    E        
Sbjct: 720 NAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIE-------- 771

Query: 460 SSTASSMELEELRHEKEMQREEIQKLMGQIHQ-----------LRSELQDMEAQQVNEAE 508
                   LE    +K+ Q +E +K M  + Q           L   L + + +   E  
Sbjct: 772 -------RLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENM 824

Query: 509 SAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQ 568
              E L+ L +Q++ +    ++L++ LE  K+E       L   K   + ++K + EE+ 
Sbjct: 825 KKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVY 884

Query: 569 KLRNQLTNKTLSNSSQSE----LENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQ 624
            L+ +L  K  S    SE    L++ L Q  + L Q+      L   +  L  Q+ +LEQ
Sbjct: 885 CLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQ 944

Query: 625 QMNSASGSSS 634
           ++     SS+
Sbjct: 945 ELQKQRESSA 954


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 111/483 (22%), Positives = 203/483 (42%), Gaps = 93/483 (19%)

Query: 223  ELSNLRLENQLLRNEVQSLNQEM-ASLLQRSKETQEELNKARARVEKWNADHSKSDRMTR 281
            E  N+  E      E+ +  +EM A L  + +E +E L+   +RVE+    +       +
Sbjct: 887  EEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKK 946

Query: 282  GLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNS 341
             ++A + DL E +  ++     L++    A+  +    E +  L+ + S+ ++++     
Sbjct: 947  KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK----- 1001

Query: 342  LQNQALQTFQERLHEADATLKREQESYKQ----------MQSEFAARLNKVEMERQNLAE 391
                  +  ++R+ E  + L  E+E  K           M S+   RL K E  RQ L +
Sbjct: 1002 ------KLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK 1055

Query: 392  AITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELID----------YKQKATRILQS 441
            A    + + +D + ++ ELQ Q+   KL L   ++EL            +K  A ++++ 
Sbjct: 1056 AKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE 1115

Query: 442  KEKLINSLKEGSGFEGLDSSTAS------SMELE-----------------ELRHEKEMQ 478
             +  I  L+E    E    + A       S ELE                 ELR ++E +
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE 1175

Query: 479  REEIQK-LMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETE--- 534
              E++K L  +     +++QDM  +     E   EQL+      A  + +KQ LET+   
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235

Query: 535  -------LERLKQEFHYIEEDLYRTKNTLQSRIKDRD-------EEIQKLRNQLTN-KTL 579
                   L+++K E  +  + L      L +++ + D       E+  KL+N+L N  TL
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295

Query: 580  SNSSQ----------SELENRLHQLTETLIQKQT--------MLESLSTEKNSLVFQLER 621
               ++          + LE++L Q T+ L+Q++T         +  L  EKNSL  Q E 
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQL-QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354

Query: 622  LEQ 624
             E+
Sbjct: 1355 EEE 1357



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 90/442 (20%), Positives = 197/442 (44%), Gaps = 42/442 (9%)

Query: 220  KSHELSNLRLENQLL--RNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSD 277
            K+ E   L L++QL   + +V      + SL +  K+  ++      R+E+    + K +
Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE 1419

Query: 278  RMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQS 337
            +    L+ ++DDLT  +  +    + L+ + ++ DQLL+           E+ R   +  
Sbjct: 1420 KTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAR 1479

Query: 338  EGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAE 397
            E  +      +  +E L EA    +R+ +  +    +  +  + V      L ++    E
Sbjct: 1480 EKETKALSLARALEEAL-EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALE 1538

Query: 398  RKYSDEKKRVDELQQQVKLY---KLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSG 454
            ++  + + +++EL+ +++     KL LE + Q +   K +  R LQ++++          
Sbjct: 1539 QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM---KAQFERDLQTRDE---------- 1585

Query: 455  FEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESARE-- 512
             +  +       ++ EL  E E +R++    +    ++  +L+D+EAQ +  A  AR+  
Sbjct: 1586 -QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ-IEAANKARDEV 1643

Query: 513  ---------QLQDLHDQIAGQKASKQEL-------ETELERLKQEFHYIEEDLYRTKNTL 556
                     Q++D   ++   +AS+ E+       E +L+ L+ E   ++E+L  ++   
Sbjct: 1644 IKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERAR 1703

Query: 557  QSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLV 616
            +   ++RDE   ++ N  + K+     +  LE R+ QL E L ++Q+ +E L+       
Sbjct: 1704 RHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTT 1763

Query: 617  FQLERLEQQM---NSASGSSSN 635
             Q++ L  ++    SA+  S N
Sbjct: 1764 LQVDTLNAELAAERSAAQKSDN 1785



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 91/426 (21%), Positives = 195/426 (45%), Gaps = 41/426 (9%)

Query: 243  QEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLA 302
            ++ ASL  + ++TQE L +   +    ++   + +     L+ Q ++  EA    + Q+ 
Sbjct: 1308 KDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367

Query: 303  VLKVRLQEADQLLSTRTEALEALQSEKSRIMQD------QSEGNSLQNQALQTFQERLHE 356
             L+ +L +  + +      +E+L+  K ++++D      + E  +L    L+  + RL +
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1427

Query: 357  ADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKL 416
                L  + +  +Q+ S    +  K +   Q LAE  +++ R Y++E+ R +   ++ + 
Sbjct: 1428 ELDDLTVDLDHQRQVASNLEKKQKKFD---QLLAEEKSISAR-YAEERDRAEAEAREKET 1483

Query: 417  YKLNLESSKQELIDYKQKATR----ILQSKEKLINSLKE-GSGFEGLD-SSTASSMELEE 470
              L+L  + +E ++ K++  R    +    E L++S  + G     L+ S  A   ++EE
Sbjct: 1484 KALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEE 1543

Query: 471  LRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQ----------------- 513
            +R + E   +E+Q       +L   +Q M+AQ   + ++  EQ                 
Sbjct: 1544 MRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA 1603

Query: 514  -LQDLHDQIAGQKASKQELETELERLKQEF---HYIEEDLYRTKNTLQSRIKDRDEEIQK 569
             L+D   Q A   ASK+++E +L+ L+ +    +   +++ +    LQ+++KD   E+++
Sbjct: 1604 ELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEE 1663

Query: 570  LRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQM-NS 628
             R    ++    +   E E +L  L   ++Q Q  L S    +     + + L  ++ NS
Sbjct: 1664 AR---ASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720

Query: 629  ASGSSS 634
            ASG S+
Sbjct: 1721 ASGKSA 1726



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 102/464 (21%), Positives = 201/464 (43%), Gaps = 26/464 (5%)

Query: 192  EGQEESSKENVSSNAACPDHTPTPNDDGKS-HEL--SNLRLENQL--LRNEVQSLNQEMA 246
            E +EE  ++N    A   D   + +D GK+ HEL  S   LE Q+  +R +++ L  E+ 
Sbjct: 1497 EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ 1556

Query: 247  SLLQRSKETQEELNKARARVEK-WNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLK 305
            +        +  +   +A+ E+       +++   R L  QV +L   +  +  Q A+  
Sbjct: 1557 ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAV 1616

Query: 306  VRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQ 365
               ++ +  L      +EA    +  +++   +   LQ Q ++ +Q  L EA A+  R++
Sbjct: 1617 ASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK---LQAQ-MKDYQRELEEARAS--RDE 1670

Query: 366  ESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSK 425
               +  +SE   +L  +E E   L E +  +ER     ++  DEL  ++     N  S K
Sbjct: 1671 IFAQSKESE--KKLKSLEAEILQLQEELASSERARRHAEQERDELADEIT----NSASGK 1724

Query: 426  QELIDYKQKA-TRILQSKEKLINSLKEGSGFEGL-DSSTASSMELEELRHEKEMQREEIQ 483
              L+D K++   RI Q +E+L    +E S  E L D    ++++++ L  E   +R   Q
Sbjct: 1725 SALLDEKRRLEARIAQLEEELE---EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ 1781

Query: 484  KLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFH 543
            K      QL  + ++++A+ + E E A +        I+  +A   +LE +LE+  +E  
Sbjct: 1782 KSDNARQQLERQNKELKAK-LQELEGAVKS--KFKATISALEAKIGQLEEQLEQEAKERA 1838

Query: 544  YIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQT 603
               + + RT+  L+      ++E +           +N+   +L+ +L +  E   +   
Sbjct: 1839 AANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANA 1898

Query: 604  MLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNG 647
                L  E +      E L +++++       G  I+ S   +G
Sbjct: 1899 SRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSG 1942



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 104/484 (21%), Positives = 204/484 (42%), Gaps = 95/484 (19%)

Query: 223  ELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNAD---------- 272
            E  N   + Q +R    +  +E++  L+++K  +  L K +  +E  N +          
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQ 1245

Query: 273  -HSKSDRMTRGLRAQVDDLTEAVAAKD--------------SQLAVLKVRLQEADQ---- 313
              ++S+   + L AQV +L   V+  D              ++L  +   L+EA++    
Sbjct: 1246 VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305

Query: 314  -------LLSTRTEALEALQSE-------KSRIMQDQSEGNSLQNQALQTFQERLHEADA 359
                   L S   +  E LQ E        SRI Q + E NSLQ Q     QE   EA  
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ-----QEEEEEARK 1360

Query: 360  TLKRE--------QESYKQMQSEFAARLNKVEMERQNLAEAITLAER------KYSDEKK 405
             L+++         ++ K++  +     +  E +++ L +A  L++R       Y   +K
Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEK 1420

Query: 406  RVDELQQQVKLYKLNLESSKQ--ELIDYKQKATRILQSKEKLINS-------LKEGSGFE 456
              + LQQ++    ++L+  +Q    ++ KQK    L ++EK I++         E    E
Sbjct: 1421 TKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEARE 1480

Query: 457  GLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRS----------ELQDMEAQQVNE 506
                + + +  LEE    KE    + ++L   +  L S          EL+  +     +
Sbjct: 1481 KETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQ 1540

Query: 507  AESAREQLQDLHDQIAGQKASKQELETELERLKQEF----HYIEEDLYRTKNTLQSRIKD 562
             E  R QL++L D++   + +K  LE  ++ +K +F       +E     K  L  ++++
Sbjct: 1541 VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRE 1600

Query: 563  RDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERL 622
             + E++  R Q   + L+ +S+ ++E  L  L       +  +E+ +  ++ ++ QL +L
Sbjct: 1601 LEAELEDERKQ---RALAVASKKKMEIDLKDL-------EAQIEAANKARDEVIKQLRKL 1650

Query: 623  EQQM 626
            + QM
Sbjct: 1651 QAQM 1654



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 65/289 (22%), Positives = 136/289 (47%), Gaps = 32/289 (11%)

Query: 361  LKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLN 420
            L R+  + KQ Q      L+ +++ ++N A  + L   ++     +V  L Q V   +  
Sbjct: 801  LARKAFAKKQQQ------LSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQ-VTRQEEE 853

Query: 421  LESSKQELIDYKQKATRI---LQSKEKLINSLKEGSGF--EGLDSSTASSMELEELRHEK 475
            L++  +EL+  K+K T++   L+  E+    L E      E L + T    E EE+R   
Sbjct: 854  LQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARL 913

Query: 476  EMQREEIQKLMGQIHQLRSELQDMEAQQV---NEAESAREQLQDLHDQIAGQKASKQEL- 531
              +++E+++++   H L S +++ E +     NE +  +  +QDL +Q+  ++ ++Q+L 
Sbjct: 914  AAKKQELEEIL---HDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970

Query: 532  ------ETELERLKQEFHYIEED---LYRTKNTLQSRIKDRD----EEIQKLRNQLTNKT 578
                  E +++++++E   +E+      + K  ++ RI +      EE +K +N    + 
Sbjct: 971  LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030

Query: 579  LSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMN 627
                  S+LE RL +  +T  + +     L  E   L  Q+  L+ Q++
Sbjct: 1031 KQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID 1079



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 74/352 (21%), Positives = 163/352 (46%), Gaps = 53/352 (15%)

Query: 286  QVDDLTEAVAAKDSQLAVLKVR-------LQEAD----QLLSTRTEALEALQSEKSRIMQ 334
            QV    E + AKD +L  +K +       L+E +    QLL  +    E LQ+E + +  
Sbjct: 846  QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE-TELFA 904

Query: 335  DQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAIT 394
            +  E  +      Q  +E LH+ ++ ++ E+E  + +Q+E      K++   Q+L E   
Sbjct: 905  EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNE----KKKMQAHIQDLEEQ-- 958

Query: 395  LAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSG 454
            L E + + +K +++++  + K+ K+     ++E++  + + ++ ++ K+ + + + E S 
Sbjct: 959  LDEEEGARQKLQLEKVTAEAKIKKM-----EEEILLLEDQNSKFIKEKKLMEDRIAECSS 1013

Query: 455  FEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQL 514
               L      +  L ++R+++E+   ++++ + +  + R EL+  +A++  + E+     
Sbjct: 1014 --QLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELE--KAKRKLDGETT---- 1065

Query: 515  QDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQL 574
             DL DQIA  +A   EL+ +L + ++E              LQ  +   D+E     N L
Sbjct: 1066 -DLQDQIAELQAQIDELKLQLAKKEEE--------------LQGALARGDDETLHKNNAL 1110

Query: 575  TNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQM 626
                       EL+ ++ +L E    ++        +K  L  +LE L+ ++
Sbjct: 1111 -------KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL 1155



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 30/124 (24%), Positives = 63/124 (50%), Gaps = 13/124 (10%)

Query: 512 EQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDE---EIQ 568
           E+LQ   +++   K  + ++E ELE ++++   + E+    KN L  +++   E   E +
Sbjct: 852 EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEE----KNILAEQLQAETELFAEAE 907

Query: 569 KLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
           ++R +L  K      + ELE  LH L   + +++   + L  EK  +   ++ LE+Q++ 
Sbjct: 908 EMRARLAAK------KQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961

Query: 629 ASGS 632
             G+
Sbjct: 962 EEGA 965



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 54/280 (19%), Positives = 115/280 (41%), Gaps = 23/280 (8%)

Query: 107  SSHFVRRKKSEPDDELLFDFLNSSQKEPTGRVEIRKEKGKTPVFQSS---QTSSVSSVNP 163
            SS   RR   +  DEL  +  NS+  +     E R+ + +    +     + S++  +N 
Sbjct: 1698 SSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757

Query: 164  SV--TTIKTIEENSFGSQTHEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKS 221
                TT++    N+  +    AA  SD++ +  E  +KE     A   +         K+
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE---LKAKLQELEGAVKSKFKA 1814

Query: 222  HELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVE-------KWNADHS 274
              +S L  +   L  +++   +E A+  +  + T+++L +   +VE       ++     
Sbjct: 1815 -TISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQME 1873

Query: 275  KSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQ 334
            K++   + L+ Q+++  E     ++    L+  L +A       TEA E L  E S +  
Sbjct: 1874 KANARMKQLKRQLEEAEEEATRANASRRKLQRELDDA-------TEANEGLSREVSTLKN 1926

Query: 335  DQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSE 374
                G  +   + ++ + +LH   A+L+   +  +   S+
Sbjct: 1927 RLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSD 1966


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 95/421 (22%), Positives = 191/421 (45%), Gaps = 51/421 (12%)

Query: 243  QEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLA 302
            +EMA++ +  ++T+EEL K  A+         + +     L  + +DL   V A+   LA
Sbjct: 851  KEMANMKEEFEKTKEELAKTEAK-------RKELEEKMVTLMQEKNDLQLQVQAEADSLA 903

Query: 303  VLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLK 362
              + R    DQL+ T+ + LEA   E +   +D+ E N+     L   + +L +  + LK
Sbjct: 904  DAEER---CDQLIKTKIQ-LEAKIKEVTERAEDEEEINA----ELTAKKRKLEDECSELK 955

Query: 363  REQESYKQMQSEFAARLNKVEMERQNLAEAITLAER---KYSDEKKRVDELQQQ------ 413
            ++ +  +   ++     +  E + +NL E +   +    K + EKK + E  QQ      
Sbjct: 956  KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1015

Query: 414  --------VKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASS 465
                    +   K+ LE    +L    ++  +I    E+    L EG     L  +  S+
Sbjct: 1016 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKL-EGD----LKLAQEST 1070

Query: 466  MELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEA---QQVNEAESAREQLQDLHDQIA 522
            M++E   ++K+   E+++K   ++  L+S+++D +A   Q   + +  + ++++L ++I 
Sbjct: 1071 MDIE---NDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIE 1127

Query: 523  GQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRI---KDRDEEIQKLRNQLTNKTL 579
             ++AS+ + E +   L +E   I E L        ++I   K R+ E QK+R  L   TL
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1187

Query: 580  SNSSQSELENRLH-----QLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSS 634
             + + +    + H     +L E +   Q + + L  EK+ +  +++ L   M + S +  
Sbjct: 1188 QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKG 1247

Query: 635  N 635
            N
Sbjct: 1248 N 1248



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 90/411 (21%), Positives = 182/411 (44%), Gaps = 55/411 (13%)

Query: 246  ASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVL- 304
            A L  + ++ ++E ++ +  ++      +K ++       +V +LTE +A  D  +A L 
Sbjct: 938  AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLT 997

Query: 305  --KVRLQEADQL----LSTRTEALEALQSEKSRIMQ--DQSEGNSLQNQALQTFQERL-H 355
              K  LQEA Q     L    + +  L   K ++ Q  D  EG+  Q + ++   ER   
Sbjct: 998  KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKR 1057

Query: 356  EADATLKREQESYKQMQSE---FAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQ 412
            + +  LK  QES   ++++      +L K E E   L   I   +      +K++ ELQ 
Sbjct: 1058 KLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQA 1117

Query: 413  QVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELR 472
            +++  +  +E+ +      +++ + + +  E++   L+E  G      +T++ +E+ + R
Sbjct: 1118 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG------ATSAQIEMNKKR 1171

Query: 473  HEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELE 532
             E E Q+            +R +L++   Q    A + R++  D   ++  Q  + Q ++
Sbjct: 1172 -EAEFQK------------MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1218

Query: 533  TELERLKQEFHYIEEDLYRTKNTLQ-----------------SRIKDRDEEIQKLRNQLT 575
             +LE+ K E     +DL     T+                  S IK ++EE Q+L N LT
Sbjct: 1219 QKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLT 1278

Query: 576  NKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQM 626
                  + ++ L+    + +  L +K T++  LS  K +   Q+E L++Q+
Sbjct: 1279 ------AQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQL 1323



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 105/504 (20%), Positives = 216/504 (42%), Gaps = 64/504 (12%)

Query: 192  EGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQL--LRNEVQSLNQEMASLL 249
            E  EE+ K+         +H    N    S E +  RL+N++  L  +V+  N   A+L 
Sbjct: 1388 EELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALD 1447

Query: 250  QRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQ 309
            ++ +   + L + + + E+ +A+   S + +R L  ++  +  A      QL  LK   +
Sbjct: 1448 KKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENK 1507

Query: 310  EADQLLSTRTEAL-------EALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLK 362
               Q +S  TE +         L+  K ++ Q++SE            Q  L EA+A+L+
Sbjct: 1508 NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSE-----------LQAALEEAEASLE 1556

Query: 363  REQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQ----VKLYK 418
             E+    ++Q E    LN+V+ E           +RK +++ + +D++++     V+  +
Sbjct: 1557 HEEGKILRIQLE----LNQVKSE----------VDRKIAEKDEEIDQMKRNHIRIVESMQ 1602

Query: 419  LNLES---SKQELIDYKQKATRILQSKEKLIN--------SLKEGSGFEGLDSSTASSME 467
              L++   S+ + I  K+K    L   E  +N        +L+     + +   T   ++
Sbjct: 1603 STLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLD 1662

Query: 468  -----LEELRHEKEMQREEIQKLMGQIHQLRSELQDME-AQQVNEAE--SAREQLQDLHD 519
                  E+L+ +  M       L  +I +LR+ L+  E ++++ E E   A E++Q LH 
Sbjct: 1663 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1722

Query: 520  QIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTL 579
            Q      +K++LET++ +++ E     ED+ +     + + K    +   +  +L  +  
Sbjct: 1723 QNTSLINTKKKLETDISQIQGEM----EDIIQEARNAEEKAKKAITDAAMMAEELKKEQD 1778

Query: 580  SNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSI 639
            +++    ++  L Q  + L  +    E L+ +      Q+++LE ++    G   +    
Sbjct: 1779 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKK--QIQKLEARVRELEGEVESEQKR 1836

Query: 640  NMSGIDNGEGTRLRNVPVLFNDTE 663
            N+  +  G     R V  L   TE
Sbjct: 1837 NVEAV-KGLRKHERKVKELTYQTE 1859



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 93/448 (20%), Positives = 179/448 (39%), Gaps = 55/448 (12%)

Query: 220  KSHELSNLRL---ENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKS 276
            K  E+S L+    + Q L  ++Q   +E+ + ++  +E  E    +RA+ EK  +D    
Sbjct: 1087 KEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD---- 1142

Query: 277  DRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQ 336
              ++R L    + L EA  A  +Q+ + K R  E  ++     EA   LQ E +     +
Sbjct: 1143 --LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEA--TLQHEATAATLRK 1198

Query: 337  SEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLA 396
               +S+     Q   + L      L++E+   K    + A+ +  V   + NL +     
Sbjct: 1199 KHADSVAELGEQI--DNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRAL 1256

Query: 397  ERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGF- 455
            E + S+ K + +E Q+ +     +L + +  L     + +R L  K+ L++ L  G    
Sbjct: 1257 EDQLSEIKTKEEEQQRLIN----DLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAF 1312

Query: 456  ------------EGLDSSTASSMELEELRHEKEMQRE----------EIQKLMG----QI 489
                        E + + +A +  L+  RH+ ++ RE          E+Q+ M     ++
Sbjct: 1313 TQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEV 1372

Query: 490  HQLRSELQDMEAQQVNEAESAR----EQLQDLHDQI-------AGQKASKQELETELERL 538
             Q R++ +    Q+  E E A+    ++LQD  + +       A  + +KQ L+ E+E L
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1432

Query: 539  KQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETL 598
              +               ++  K   E  QK          S      L   L ++    
Sbjct: 1433 MIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAY 1492

Query: 599  IQKQTMLESLSTEKNSLVFQLERLEQQM 626
             +    LE+L  E  +L  ++  L +Q+
Sbjct: 1493 EESLDQLETLKRENKNLQQEISDLTEQI 1520



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 65/287 (22%), Positives = 138/287 (48%), Gaps = 45/287 (15%)

Query: 370  QMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELI 429
            + + E A    + E  ++ LA+  T A+RK  +EK  +  L Q+    +L +++    L 
Sbjct: 848  ETEKEMANMKEEFEKTKEELAK--TEAKRKELEEK--MVTLMQEKNDLQLQVQAEADSLA 903

Query: 430  DYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQI 489
            D +++  +++++K +L   +KE          T  + + EE+  E   ++   +KL  + 
Sbjct: 904  DAEERCDQLIKTKIQLEAKIKE---------VTERAEDEEEINAELTAKK---RKLEDEC 951

Query: 490  HQLRSELQDME---AQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFH--- 543
             +L+ ++ D+E   A+   E  +   ++++L +++AG   +  +L  E + L QE H   
Sbjct: 952  SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL-QEAHQQT 1010

Query: 544  ----YIEED----LYRTKNTLQSRIKDRD---EEIQKLRNQLT--------NKTLSNSSQ 584
                  EED    L + K  L+ ++ D +   E+ +K+R  L         +  L+  S 
Sbjct: 1011 LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQEST 1070

Query: 585  SELENRLHQLTETLIQKQ---TMLESLSTEKNSLVFQLERLEQQMNS 628
             ++EN   QL E L +K+   + L+S   ++ +L  QL++  +++ +
Sbjct: 1071 MDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQA 1117



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 54/233 (23%), Positives = 106/233 (45%), Gaps = 30/233 (12%)

Query: 409  ELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMEL 468
            E ++++   K   E +K+EL   + K   +   +EK++  ++E +  +    + A S+  
Sbjct: 848  ETEKEMANMKEEFEKTKEELAKTEAKRKEL---EEKMVTLMQEKNDLQLQVQAEADSLAD 904

Query: 469  EELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASK 528
             E R + ++ + +IQ L  +I ++    +D E  ++N   +A+++   L D+ +  K   
Sbjct: 905  AEERCD-QLIKTKIQ-LEAKIKEVTERAEDEE--EINAELTAKKR--KLEDECSELKKDI 958

Query: 529  QELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELE 588
             +LE  L ++++E H  E    + KN L   +   DE I KL  +   K L  + Q  L+
Sbjct: 959  DDLELTLAKVEKEKHATEN---KVKN-LTEEMAGLDETIAKLTKE--KKALQEAHQQTLD 1012

Query: 589  NRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINM 641
            +               L++   + N+L     +LEQQ++   GS      I M
Sbjct: 1013 D---------------LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRM 1050



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 37/202 (18%), Positives = 89/202 (44%), Gaps = 21/202 (10%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKA-------RARVEKWNADHSKSDRMTRGLRAQ 286
            L  ++  +  EM  ++Q ++  +E+  KA          ++K     +  +RM + L   
Sbjct: 1734 LETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1793

Query: 287  VDDL------TEAVAAKDS--QLAVLKVRLQEADQLLSTR----TEALEALQSEKSRIMQ 334
            V DL       E +A K    Q+  L+ R++E +  + +      EA++ L+  + ++ +
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKE 1853

Query: 335  --DQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEA 392
               Q+E +      LQ   ++L     + KR+ E  ++  +   ++  +++ E +   E 
Sbjct: 1854 LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEER 1913

Query: 393  ITLAERKYSDEKKRVDELQQQV 414
              +AE + +  + +  E+  ++
Sbjct: 1914 ADIAESQVNKLRVKSREVHTKI 1935


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 95/443 (21%), Positives = 199/443 (44%), Gaps = 49/443 (11%)

Query: 225  SNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRM----- 279
            +NL    Q L NE   L  E+  LLQ   +++ +  K  A++++     ++ +R+     
Sbjct: 1213 ANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELA 1272

Query: 280  --TRGLRAQVDDLTEAVAAKDSQ-------LAVLKVRLQEADQLLSTRTEALEALQSEKS 330
                 L+ ++D++T  ++  DS+        + L+ +LQ+  +LL        +L    +
Sbjct: 1273 DKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL---ST 1329

Query: 331  RIMQDQSEGNSLQNQALQTFQERLHEAD---ATLKREQESYKQMQSEFAARLNKVEMERQ 387
            ++ Q + E NS + Q L+  +E  H  +   ATL  +    K+   +    L   E  ++
Sbjct: 1330 KLKQVEDEKNSFREQ-LEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKR 1388

Query: 388  NLAEAIT-LAER------KYSDEKKRVDELQQQVKLYKLNLESSKQEL--IDYKQKATRI 438
             L + +  L++R       Y   +K    LQQ++    ++L+  +Q    ++ KQK    
Sbjct: 1389 KLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQ 1448

Query: 439  LQSKEKLINSL----KEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRS 494
            L ++EK I++     ++ +  E  +  T  ++ L     E   Q+ E+++L     Q R+
Sbjct: 1449 LLAEEKTISAKYAEERDRAEAEAREKET-KALSLARALEEAMEQKAELERLN---KQFRT 1504

Query: 495  ELQDMEAQQVNEAESARE---QLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYR 551
            E++D+ + + +  +S  E     + L  Q+   K   +ELE EL+  +     +E +L  
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQA 1564

Query: 552  TKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTM------- 604
             K   +  ++ RDE+ ++ + QL  +     ++ E E +   +     +K  M       
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEA 1624

Query: 605  -LESLSTEKNSLVFQLERLEQQM 626
             ++S +  ++  + QL +L+ QM
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQM 1647



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 105/482 (21%), Positives = 220/482 (45%), Gaps = 79/482 (16%)

Query: 218  DGKSHELSN--LRLENQLLRNE--VQSLNQEMASLLQRSKETQEELNKARARVEKWNADH 273
            D KS +L+     LE+QL   +  +Q  N++  SL  + K+ ++E N  R ++E+     
Sbjct: 1293 DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAK 1352

Query: 274  SKSDRMTRGLRAQVDDLTEAVAAKDSQLAV---LKVRLQEADQLLSTRTE----ALEALQ 326
               ++    L AQV D+ + +      L     +K +LQ+  + LS R E    A + L+
Sbjct: 1353 HNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLE 1412

Query: 327  SEKSRIMQDQSE---GNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVE 383
              K+R+ Q+  +       Q Q+    +++  + D  L  E    K + +++A   ++ E
Sbjct: 1413 KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE----KTISAKYAEERDRAE 1468

Query: 384  ME-RQNLAEAITLAE--RKYSDEKKRVDELQQQVKLYKLNLESSKQEL---IDYKQKATR 437
             E R+   +A++LA    +  ++K  ++ L +Q +    +L SSK ++   +   +K+ R
Sbjct: 1469 AEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKR 1528

Query: 438  ILQSK-EKLINSLKEGSGFEGLDSSTASSMELE------------ELRHEKEMQREEIQK 484
             L+ + E++   L+E    + L ++  + + LE            +L+   E   E+ ++
Sbjct: 1529 ALEQQVEEMKTQLEELE--DELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQ 1586

Query: 485  LMGQIHQLRSELQDMEAQQVNEAESAREQLQ-DLHD------------------------ 519
            L+ Q+ ++ +EL+D E +Q + A +AR++L+ DL D                        
Sbjct: 1587 LVRQVREMEAELED-ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQA 1645

Query: 520  -------QIAGQKASKQEL-------ETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDE 565
                   ++   +AS++E+       E +L+ ++ E   ++E+L   +   +   ++RDE
Sbjct: 1646 QMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDE 1705

Query: 566  EIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQ 625
               ++ N      L+   +  LE R+ QL E L ++Q   E ++        Q++++   
Sbjct: 1706 LADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTD 1765

Query: 626  MN 627
            +N
Sbjct: 1766 LN 1767



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 107/483 (22%), Positives = 198/483 (40%), Gaps = 92/483 (19%)

Query: 226  NLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRA 285
            N   E + L++++ +   ++   LQ   E   E  + RAR+    A   + + +   L A
Sbjct: 866  NRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARL---TAKKQELEEICHDLEA 922

Query: 286  QVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEK----SRIMQDQSEGNS 341
            +V++  E      ++   ++  +QE ++ L     A + LQ EK    +++ + + E   
Sbjct: 923  RVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQII 982

Query: 342  LQNQALQTFQE------RLHEADATLKREQESYKQ----------MQSEFAARLNKVEME 385
            L++Q  +  +E      R+ E    L  E+E  K           M ++   RL + E +
Sbjct: 983  LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ 1042

Query: 386  RQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKL 445
            RQ L +     E   +D   ++ ELQ Q+   K+ L   ++EL                 
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEEL----------------- 1085

Query: 446  INSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVN 505
                             A+   +EE   +K M  ++I++L  QI +L+ +L+   A + N
Sbjct: 1086 ----------------QAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASR-N 1128

Query: 506  EAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDE 565
            +AE                   K++L  ELE LK E   +E+ L  T    + R K R++
Sbjct: 1129 KAEK-----------------QKRDLGEELEALKTE---LEDTLDSTAAQQELRSK-REQ 1167

Query: 566  EIQKLRNQLTNKTLSNSSQ-SELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQ 624
            E+  L+  L  +  ++ +Q  E+  +  Q  E L ++   LE     K +    LE+ +Q
Sbjct: 1168 EVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ---LEQTKRVKAN----LEKAKQ 1220

Query: 625  QMNSASGSSSNGSSINMSGIDNGEGTR------LRNVPVLFNDTETNLAGMYGKVRKAAS 678
             + +  G  +N   + + G  + E  R      L+ + V FN+ E     +  KV K   
Sbjct: 1221 TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQV 1280

Query: 679  SID 681
             +D
Sbjct: 1281 ELD 1283



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 91/431 (21%), Positives = 179/431 (41%), Gaps = 39/431 (9%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEA 293
            L +++  L  ++A L  +  + +EEL  A ARVE+  A  + + +  R L +Q+ +L E 
Sbjct: 1060 LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQED 1119

Query: 294  V-AAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQE 352
            + + + S+    K +    ++L + +TE  + L S  ++  + +S+     N   +T +E
Sbjct: 1120 LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQ-QELRSKREQEVNILKKTLEE 1178

Query: 353  RLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEA----------------ITLA 396
                 +A ++  ++ + Q   E A +L + +  + NL +A                + L 
Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ 1238

Query: 397  ERKYSDEKKRVDELQQQVKLYKLNL-ESSKQELIDYKQKATRILQSKEKLINSLKEGSGF 455
             +  S+ K++  E Q Q    K N  E  + EL D   K    L +   L++     S  
Sbjct: 1239 GKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSK 1298

Query: 456  EGLDSSTASS--MELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQ 513
               D S   S   + +EL  E+  Q+  +   + Q+   ++  ++   ++     +  +Q
Sbjct: 1299 LTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQ 1358

Query: 514  LQDLHDQIAGQKAS--------------KQELETELERLKQ---EFHYIEEDLYRTKNTL 556
            +  LH Q+A  K                K++L+ +LE L Q   E     + L +TK  L
Sbjct: 1359 IATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRL 1418

Query: 557  QSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLV 616
            Q  + D   ++   R    N         +L      ++    +++   E+ + EK +  
Sbjct: 1419 QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 1478

Query: 617  FQLER-LEQQM 626
              L R LE+ M
Sbjct: 1479 LSLARALEEAM 1489



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 109/562 (19%), Positives = 232/562 (41%), Gaps = 45/562 (8%)

Query: 113  RKKSEPDDELLFDFLNSSQKEPTGRVEIRKEKGKTPVFQ-SSQTSSVSSVNPSVTTIKTI 171
            R K E +  +L   L    K    +++  ++K    V + + Q      V  ++   K  
Sbjct: 1162 RSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221

Query: 172  EENSFGSQTHEAA----SNSDSSHEGQE---ESSKENVSSNAACPDHTPTPNDDGKSH-E 223
             EN  G   +E         DS H+ ++   +  +  V  N      T   +   K   E
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 1281

Query: 224  LSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGL 283
            L N+        ++   L ++ ++L  + ++TQE L +   +    +    + +      
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSF 1341

Query: 284  RAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQ 343
            R Q+++  EA    + Q+A L  ++ +  + +      LE  +  K ++ +D  EG S +
Sbjct: 1342 REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDL-EGLSQR 1400

Query: 344  NQALQTFQERLHEADATLKREQESYK---QMQSEFAARLNKVEME-RQNLAEAITLAERK 399
            ++      ++L +    L++E +        Q + A  L K + +  Q LAE  T++  K
Sbjct: 1401 HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA-K 1459

Query: 400  YSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQS----KEKLINSLKE-GSG 454
            Y++E+ R +   ++ +   L+L  + +E ++ K +  R+ +      E L++S  + G  
Sbjct: 1460 YAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKS 1519

Query: 455  FEGLDSST-ASSMELEELRHEKEMQREEIQ-----------KLMGQIHQLRSELQ----- 497
               L+ S  A   ++EE++ + E   +E+Q            L     Q   +LQ     
Sbjct: 1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQ 1579

Query: 498  --DMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEF---HYIEEDLYRT 552
              + + Q V +      +L+D   Q +   A++++LE +L+ L+      +   ++  + 
Sbjct: 1580 SEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQ 1639

Query: 553  KNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEK 612
               LQ+++KD   E+   R    ++    +   E E +L  +   +IQ Q  L +    K
Sbjct: 1640 LRKLQAQMKDCMRELDDTR---ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAK 1696

Query: 613  NSLVFQLERLEQQMNSASGSSS 634
                 + + L  ++ ++SG  +
Sbjct: 1697 RQAQQERDELADEIANSSGKGA 1718



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 98/457 (21%), Positives = 200/457 (43%), Gaps = 72/457 (15%)

Query: 228  RLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARA--RVEKWNADHSKSDRMTRGLRA 285
            R E +    E ++L+  +A  L+ + E + EL +     R E  +   SK D     +  
Sbjct: 1466 RAEAEAREKETKALS--LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDD-----VGK 1518

Query: 286  QVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEA-------LEALQSEKSRIMQDQSE 338
             V +L ++  A + Q+  +K +L+E +  L    +A       L+A++++  R +Q + E
Sbjct: 1519 SVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDE 1578

Query: 339  GNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAER 398
             +  + + L     ++ E +A L+ E+   KQ     AAR  K+EM+ ++L   I  A +
Sbjct: 1579 QSEEKKKQLV---RQVREMEAELEDER---KQRSMAVAAR-KKLEMDLKDLEAHIDSANK 1631

Query: 399  KYSDEKKRVDELQQQVKLYKLNLE---SSKQELIDYKQKATRILQSKEKLINSLKEGSGF 455
               +  K++ +LQ Q+K     L+   +S++E++   ++  + L+S E  +  L+E    
Sbjct: 1632 NRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAA 1691

Query: 456  -----------------EGLDSSTASSMELEELRH--------EKEMQREE--------- 481
                             E  +SS   ++ LEE R         E+E++ E+         
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDR 1751

Query: 482  IQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELE--------T 533
            ++K   QI Q+ ++L ++E     + E+AR+QL+  + ++   K   QE+E         
Sbjct: 1752 LKKANLQIDQINTDL-NLERSHAQKNENARQQLERQNKEL---KVKLQEMEGTVKSKYKA 1807

Query: 534  ELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQ 593
             +  L+ +   +EE L       Q+  K      +KL++ L        +  + +++  +
Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADK 1867

Query: 594  LTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSAS 630
             +  L Q +  LE    E         +L++++  A+
Sbjct: 1868 ASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDAT 1904



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 87/395 (22%), Positives = 168/395 (42%), Gaps = 56/395 (14%)

Query: 217  DDGKSHELSNLRLENQL----------LRNEVQSLNQEMASLLQRSKETQEELNKARARV 266
            D+ ++ E + LRLE  L          L+   +   ++   L+++ +E + EL   R + 
Sbjct: 1546 DELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQR 1605

Query: 267  EKWNADHSKSDRMTRGLRAQVDDLT----EAVAAKDSQLAVLKVRLQEADQLLSTRTEAL 322
                A   K +   + L A +D       EA+       A +K  ++E D   ++R E L
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665

Query: 323  EALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKV 382
               +  + ++        S++ + +Q  QE L  A+   ++ Q+   ++  E A    K 
Sbjct: 1666 AQAKENEKKL-------KSMEAEMIQ-LQEELAAAERAKRQAQQERDELADEIANSSGKG 1717

Query: 383  EM---ERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELI---DYKQKAT 436
             +   E++ L   I   E +  +E+   + +  ++K   L ++    +L     + QK  
Sbjct: 1718 ALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNE 1777

Query: 437  RILQSKEKLINSLK------EGSGFEGLDSS-TASSMELEELRHEKEMQREEIQKLMGQI 489
               Q  E+    LK      EG+      +S TA   ++ +L  + + + +E Q    Q+
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1837

Query: 490  HQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDL 549
             +   +L+D+  Q  +E  +A EQ +D  D     KAS     T L++LK++    EE+ 
Sbjct: 1838 RRTEKKLKDVLLQVDDERRNA-EQYKDQAD-----KAS-----TRLKQLKRQLEEAEEEA 1886

Query: 550  YR---TKNTLQSRIKDRDE-------EIQKLRNQL 574
             R   ++  LQ  ++D  E       E+  L+N+L
Sbjct: 1887 QRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 58/330 (17%), Positives = 138/330 (41%), Gaps = 21/330 (6%)

Query: 216  NDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSK 275
            N D    +L  L+ + +    E+         +L ++KE +++L    A + +   + + 
Sbjct: 1632 NRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAA 1691

Query: 276  SDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQD 335
            ++R  R  + + D+L + +A    + A+     +  +  ++   E LE  Q   + ++ D
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQG-NTELIND 1750

Query: 336  QSEGNSLQNQALQT--------------FQERLHEADATLK-REQESYKQMQSEFAARLN 380
            + +  +LQ   + T               +++L   +  LK + QE    ++S++ A + 
Sbjct: 1751 RLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASIT 1810

Query: 381  KVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQ 440
             +E +   L E +    ++     K+V   ++++K   L ++  ++    YK +A +   
Sbjct: 1811 ALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAST 1870

Query: 441  SKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDME 500
              ++L   L+E       + +  ++    +L+ E E   E    +  ++  L+++L+  +
Sbjct: 1871 RLKQLKRQLEEAE-----EEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGD 1925

Query: 501  AQQVNEAESAREQLQDLHDQIAGQKASKQE 530
               V     AR+   D  D+    KA   E
Sbjct: 1926 LPFVVPRRMARKGAGDGSDEEVDGKADGAE 1955



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 51/234 (21%), Positives = 112/234 (47%), Gaps = 21/234 (8%)

Query: 413  QVKLYKLNLESSKQELIDYKQK---ATRILQSKEKLINSL--KEGSGFEGLDSSTASSME 467
            QV   +  + + ++EL+  ++K   A   L   E L + L  ++    E L + T    E
Sbjct: 839  QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898

Query: 468  LEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVN-EAESAREQLQDLHDQIAGQKA 526
             EELR     +++E++++   + + R E ++   Q +  E +  ++ +Q+L +Q+  +++
Sbjct: 899  AEELRARLTAKKQELEEICHDL-EARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES 957

Query: 527  SKQEL-------ETELERLKQEFHYIEED---LYRTKNTLQSRIKD----RDEEIQKLRN 572
            ++Q+L       E +L++L++E   +E+    L + K  L+ RI +      EE +K ++
Sbjct: 958  ARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKS 1017

Query: 573  QLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQM 626
                K    +  ++LE RL +  +   + +     L  +   L  Q+  L+ Q+
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071


>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
          Length = 971

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 91/414 (21%), Positives = 189/414 (45%), Gaps = 32/414 (7%)

Query: 232 QLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLT 291
           Q+L+ ++    +   +LL + KE + EL  AR R+++  +D          L+A    +T
Sbjct: 218 QVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQAT--QMT 275

Query: 292 EAVAAKDSQLAVLKV-----RLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQA 346
           + V  KD +    +V     +L+E    L ++T++L+  + +K +I++ + + N  +   
Sbjct: 276 QEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLD--EEQKQQILELEKKVNEAKRTQ 333

Query: 347 LQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKR 406
            + ++  L    + L   +E   Q+    +  L ++  +     EA+        D+KK 
Sbjct: 334 QEYYERELKNLQSRL---EEEVTQLNEAHSKTLEELAWKHHMAIEAVH--SNAIRDKKKL 388

Query: 407 VDELQQQVKLYKLNLESSKQELIDYKQKATRILQSK-----------EKLINSLKEGSGF 455
             +L++Q    KLNLE  K +L    +    +L+ K           + ++   ++G G 
Sbjct: 389 QMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGS 448

Query: 456 -EGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQL 514
            EGL +S   S E   L++E ++ ++ +++    +  +  EL+  E QQ  E  +A ++ 
Sbjct: 449 AEGLIASLQDSQE--RLQNELDLTKDSLKETKDALLNVEGELEQ-ERQQHEETIAAMKEE 505

Query: 515 QDLH-DQIAGQKASK--QELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLR 571
           + L  D++A     K  + L  E  +L++E     E+  ++  +   ++KDR++   +  
Sbjct: 506 EKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDS 565

Query: 572 NQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQ 625
            Q   + L N      +N   QL+++    Q +    + E+  L  +LE LE+Q
Sbjct: 566 WQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQ 619



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 95/435 (21%), Positives = 189/435 (43%), Gaps = 69/435 (15%)

Query: 212 TPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEK--- 268
           T + +++ K   L   +  N+  R + +   +E+ +L  R +E   +LN+A ++  +   
Sbjct: 308 TQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELA 367

Query: 269 WN------ADHSKSDRMTRGLRAQVDD--------LTEAVAAKDSQLAVLKVRLQEADQL 314
           W       A HS + R  + L+  +++        L E       +L  LK  L++    
Sbjct: 368 WKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDK--- 424

Query: 315 LSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERL-HEADATLKREQESYKQMQS 373
           L+T  + +  LQ    +  Q       L   +LQ  QERL +E D T    ++S K+ + 
Sbjct: 425 LNTANQEIGHLQDMVRKSEQGLGSAEGLI-ASLQDSQERLQNELDLT----KDSLKETKD 479

Query: 374 EFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLY----------KLNLES 423
                  ++E ERQ   E I   +    +EK +VD++   +++           KL  E 
Sbjct: 480 ALLNVEGELEQERQQHEETIAAMKE---EEKLKVDKMAHDLEIKWTENLRQECSKLREEL 536

Query: 424 SKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQ 483
             Q   D K   +++LQ K++  N+ ++           +   ++E+L ++  + ++ ++
Sbjct: 537 RLQHEEDKKSAMSQLLQLKDREKNAARD-----------SWQKKVEDLLNQISLLKQNLE 585

Query: 484 KLMGQIHQLRSELQDMEAQQVNEAESAR---EQLQDLHDQIAGQKASKQELETELERLKQ 540
               Q+ Q ++ LQ ++AQ   E +      E+L++ H Q    K+ K       E    
Sbjct: 586 I---QLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQ--RHKSLK-------EAHVL 633

Query: 541 EFHYIEEDLYRTKNTLQSRIKDR-DEEIQKLRNQLTNKTLSNSSQSELENRLHQLT-ETL 598
            F  +EE+  + +  L++ ++ +   E+Q L++   ++      + E+E  L  L  E  
Sbjct: 634 AFQTMEEEKEKEQRALENHLQQKHSAELQSLKD--AHRESMEGFRIEMEQELQTLRFELE 691

Query: 599 IQKQTMLESLSTEKN 613
            + + ML SL +E N
Sbjct: 692 DEGKAMLASLRSELN 706



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 63/314 (20%), Positives = 136/314 (43%), Gaps = 21/314 (6%)

Query: 318 RTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAA 377
           + +AL   ++ K R+   Q    +   Q + T    + E     + +  S+ Q+Q +F  
Sbjct: 2   KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK 61

Query: 378 --RLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVK-LYKLNLESSKQELIDYKQK 434
             RL   +++  +  E   L + +  D    V++ Q++ + L+++ +ES  + L + + +
Sbjct: 62  DKRLALEDLQAAHRREIQELLKSQ-QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120

Query: 435 ATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRS 494
             ++++  E  +N  K  S +E          EL+ L+  +    E +Q    +   LR 
Sbjct: 121 RKKLIEDYEGKLN--KAQSFYE---------RELDTLKRSQLFTAESLQASKEKEADLRK 169

Query: 495 ELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKN 554
           E Q  EA         + +LQ + D+        Q+L+T L   +     +++ L   K 
Sbjct: 170 EFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKE 229

Query: 555 ---TLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTE 611
               L S+ K+ + E+   R +L  +    S      + +  L  T + ++  ++ L +E
Sbjct: 230 GEMALLSKHKEVESELAAARERLQQQA---SDLVLKASHIGMLQATQMTQEVTIKDLESE 286

Query: 612 KNSLVFQLERLEQQ 625
           K+ +  +L +LE++
Sbjct: 287 KSRVNERLSQLEEE 300


>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
          Length = 1140

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 91/414 (21%), Positives = 189/414 (45%), Gaps = 32/414 (7%)

Query: 232 QLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLT 291
           Q+L+ ++    +   +LL + KE + EL  AR R+++  +D          L+A    +T
Sbjct: 338 QVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQAT--QMT 395

Query: 292 EAVAAKDSQLAVLKV-----RLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQA 346
           + V  KD +    +V     +L+E    L ++T++L+  + +K +I++ + + N  +   
Sbjct: 396 QEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLD--EEQKQQILELEKKVNEAKRTQ 453

Query: 347 LQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKR 406
            + ++  L    + L   +E   Q+    +  L ++  +     EA+        D+KK 
Sbjct: 454 QEYYERELKNLQSRL---EEEVTQLNEAHSKTLEELAWKHHMAIEAVH--SNAIRDKKKL 508

Query: 407 VDELQQQVKLYKLNLESSKQELIDYKQKATRILQSK-----------EKLINSLKEGSGF 455
             +L++Q    KLNLE  K +L    +    +L+ K           + ++   ++G G 
Sbjct: 509 QMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGS 568

Query: 456 -EGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQL 514
            EGL +S   S E   L++E ++ ++ +++    +  +  EL+  E QQ  E  +A ++ 
Sbjct: 569 AEGLIASLQDSQE--RLQNELDLTKDSLKETKDALLNVEGELEQ-ERQQHEETIAAMKEE 625

Query: 515 QDLH-DQIAGQKASK--QELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLR 571
           + L  D++A     K  + L  E  +L++E     E+  ++  +   ++KDR++   +  
Sbjct: 626 EKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDS 685

Query: 572 NQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQ 625
            Q   + L N      +N   QL+++    Q +    + E+  L  +LE LE+Q
Sbjct: 686 WQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQ 739



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 95/435 (21%), Positives = 189/435 (43%), Gaps = 69/435 (15%)

Query: 212 TPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEK--- 268
           T + +++ K   L   +  N+  R + +   +E+ +L  R +E   +LN+A ++  +   
Sbjct: 428 TQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELA 487

Query: 269 WN------ADHSKSDRMTRGLRAQVDD--------LTEAVAAKDSQLAVLKVRLQEADQL 314
           W       A HS + R  + L+  +++        L E       +L  LK  L++    
Sbjct: 488 WKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDK--- 544

Query: 315 LSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERL-HEADATLKREQESYKQMQS 373
           L+T  + +  LQ    +  Q       L   +LQ  QERL +E D T    ++S K+ + 
Sbjct: 545 LNTANQEIGHLQDMVRKSEQGLGSAEGLI-ASLQDSQERLQNELDLT----KDSLKETKD 599

Query: 374 EFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLY----------KLNLES 423
                  ++E ERQ   E I   +    +EK +VD++   +++           KL  E 
Sbjct: 600 ALLNVEGELEQERQQHEETIAAMKE---EEKLKVDKMAHDLEIKWTENLRQECSKLREEL 656

Query: 424 SKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQ 483
             Q   D K   +++LQ K++  N+ ++           +   ++E+L ++  + ++ ++
Sbjct: 657 RLQHEEDKKSAMSQLLQLKDREKNAARD-----------SWQKKVEDLLNQISLLKQNLE 705

Query: 484 KLMGQIHQLRSELQDMEAQQVNEAESAR---EQLQDLHDQIAGQKASKQELETELERLKQ 540
               Q+ Q ++ LQ ++AQ   E +      E+L++ H Q    K+ K       E    
Sbjct: 706 I---QLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQ--RHKSLK-------EAHVL 753

Query: 541 EFHYIEEDLYRTKNTLQSRIKDR-DEEIQKLRNQLTNKTLSNSSQSELENRLHQLT-ETL 598
            F  +EE+  + +  L++ ++ +   E+Q L++   ++      + E+E  L  L  E  
Sbjct: 754 AFQTMEEEKEKEQRALENHLQQKHSAELQSLKD--AHRESMEGFRIEMEQELQTLRFELE 811

Query: 599 IQKQTMLESLSTEKN 613
            + + ML SL +E N
Sbjct: 812 DEGKAMLASLRSELN 826



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 78/395 (19%), Positives = 165/395 (41%), Gaps = 47/395 (11%)

Query: 242 NQEMASLLQRSKETQEE-----LNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAA 296
           N E  S +Q  K+  EE     L + R ++ ++ +      ++T  L     DL   +  
Sbjct: 62  NDEHESAIQALKDAHEEEIQQILAETREKILQYKS------KVTEEL-----DLRRKIQV 110

Query: 297 KDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHE 356
            +S L          +  +  + +AL   ++ K R+   Q    +   Q + T    + E
Sbjct: 111 LESSL----------EDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEE 160

Query: 357 ADATLKREQESYKQMQSEFAA--RLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQV 414
                + +  S+ Q+Q +F    RL   +++  +  E   L + +  D    V++ Q++ 
Sbjct: 161 IRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQ-QDHSASVNKGQEKA 219

Query: 415 K-LYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRH 473
           + L+++ +ES  + L + + +  ++++  E  +N  K  S +E          EL+ L+ 
Sbjct: 220 EELHRMEVESLNKMLEELRLERKKLIEDYEGKLN--KAQSFYE---------RELDTLKR 268

Query: 474 EKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELET 533
            +    E +Q    +   LR E Q  EA         + +LQ + D+        Q+L+T
Sbjct: 269 SQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQT 328

Query: 534 ELERLKQEFHYIEEDLYRTKN---TLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENR 590
            L   +     +++ L   K     L S+ K+ + E+   R +L  +    S      + 
Sbjct: 329 ALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQA---SDLVLKASH 385

Query: 591 LHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQ 625
           +  L  T + ++  ++ L +EK+ +  +L +LE++
Sbjct: 386 IGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE 420


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 114/465 (24%), Positives = 207/465 (44%), Gaps = 69/465 (14%)

Query: 187  SDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMA 246
            SDS    + E  KEN    AA  D   T  +    H+L  +++EN L   E + L + + 
Sbjct: 866  SDSLKNSKSEFEKENQKGKAAILDLEKTCKE--LKHQLQ-VQMENTL--KEQKELKKSLE 920

Query: 247  SLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKV 306
               + S + + ELN  + ++ +      ++++  + L+  +++L ++   K  Q+     
Sbjct: 921  KEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI----- 975

Query: 307  RLQEADQLLSTRTEALEALQSE-KSRIMQDQSEGNSLQNQALQTFQERLHEADA------ 359
                            EALQ E K  ++Q     N LQ Q  Q  QE   E +       
Sbjct: 976  ----------------EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN 1019

Query: 360  TLKREQESYKQMQSEFAARLNKVEMERQNLA---EAITLAERKYSDEKKRV---DELQQQ 413
              ++ QE++KQ+QS+F  R +++   RQ+L    E ++LA+      + ++   ++L Q+
Sbjct: 1020 NYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE 1079

Query: 414  VKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRH 473
            +K  K  LE    +     Q+  + LQ  +K   SLKE    + L +  +   E+EE++ 
Sbjct: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDIQKE-KSLKE----KELVNEKSKLAEIEEIKC 1134

Query: 474  EKEMQREEIQKLMGQI--HQLRS--------ELQDMEAQQVNEAESAREQLQDLHDQIA- 522
             +E   +EI KL  ++  H+L S        + + +  QQ  E +   + L+   +Q   
Sbjct: 1135 RQE---KEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKR 1191

Query: 523  GQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLT--NKTLS 580
             Q+  K +++ E E LK+EF   E  L+      +  +K  +E   KL  Q+T  N+ L 
Sbjct: 1192 NQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLG 1251

Query: 581  ------NSSQ---SELENRLHQLTETLIQKQTMLESLSTEKNSLV 616
                   SSQ   SELE +   L   +   +  +++   E+ +L+
Sbjct: 1252 TVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALL 1296



 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 117/512 (22%), Positives = 217/512 (42%), Gaps = 53/512 (10%)

Query: 140 IRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEESSK 199
           +R+   +TP    SQ S + S   S T I T++ N+  S           S    +E  K
Sbjct: 2   LRRILQRTPGRVGSQGSDLDS---SATPINTVDVNNESSSEGFICPQCMKSLGSADELFK 58

Query: 200 ENVSSNAACPDHTPTPNDDGKSHELSNLRLENQ---LLRNEVQSLNQEMASLLQRSKETQ 256
              + + A        ND G   E SNL L+     LLR EVQ L     + L+  K   
Sbjct: 59  HYEAVHDA-------GNDSGHGGE-SNLALKRDDVTLLRQEVQDLQ----ASLKEEKWYS 106

Query: 257 EELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLS 316
           EEL K   + +      +K D +     A++  L + +    ++   +K   Q  D    
Sbjct: 107 EELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIK---QMKDLFEQ 163

Query: 317 TRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFA 376
              +    +   KS+  +++S   + + +  +  +E   EA      + E  ++   E  
Sbjct: 164 KAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDV 223

Query: 377 ARLNKVEMERQNLAEAITLAERKYSDE-KKRVDELQQQVKLYKLNLESSKQELIDYKQKA 435
           A L K  ++ Q L + +TL   + S++ K    +LQ Q    +  +   + EL    Q+ 
Sbjct: 224 AVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEV 283

Query: 436 TRILQSKEKLINSL-----KEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIH 490
              +Q  +KL +S+     K  +  E L        +LEE  +E+ + ++ IQ  + Q  
Sbjct: 284 AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ-- 341

Query: 491 QLRSELQDMEAQQVNEAESARE-QLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDL 549
                 +D++ QQ+    SA E  L  +H +++ +  + Q+L+ EL  ++ ++ +++ + 
Sbjct: 342 ------KDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEF 395

Query: 550 YRTKNTLQSRIKDRDE---EIQKLRNQLTNKTLSNSSQ-SELENRLHQLTETLIQKQTML 605
                 LQ + +++++   ++Q   NQL +K L    Q  E   RL +      Q+Q   
Sbjct: 396 ----KQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKE------QRQLSS 445

Query: 606 ESLSTEKN---SLVFQLERLEQQMNSASGSSS 634
           E L  ++     L  +L RLE+Q+     +S+
Sbjct: 446 EKLMDKEQQVADLQLKLSRLEEQLKEKVTNST 477



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 110/493 (22%), Positives = 207/493 (41%), Gaps = 52/493 (10%)

Query: 178  SQTHEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNE 237
            +Q  E   N   SH+  +E+  + V    A   H     D   S E S   L +QL  ++
Sbjct: 578  TQLTEKLKNQSESHKQAQENLHDQVQEQKA---HLRAAQDRVLSLETSVNELNSQLNESK 634

Query: 238  VQS--------------LNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGL 283
             +               L+ E A   QR+ + Q  L+ A+      NA   K   + + +
Sbjct: 635  EKVSQLDIQIKAKTELLLSAEAAKTAQRA-DLQNHLDTAQ------NALQDKQQELNK-I 686

Query: 284  RAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQ 343
              Q+D +T  +  K    + L+  L+E  +   +  +  E L+ +  ++  D  E  + +
Sbjct: 687  TTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASK 746

Query: 344  NQALQTFQERLH-----EADAT-LKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAE 397
             QALQ  Q++       E  AT L ++ E  K++ S     L K     +++ + +T  E
Sbjct: 747  EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE 806

Query: 398  RKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKA--------TRILQSKEKLI--- 446
             +    K+  + L Q+ K+    L +  Q  +   QK         T +   K+KL    
Sbjct: 807  EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS 866

Query: 447  NSLKEG-SGFEGLDSS-TASSMELE----ELRHEKEMQREEIQKLMGQIHQLRSELQDME 500
            +SLK   S FE  +    A+ ++LE    EL+H+ ++Q E   K   ++ +   + ++  
Sbjct: 867  DSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEAS 926

Query: 501  AQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRI 560
             Q   E  S +EQL    + +   +  +Q+L+  +  LKQ     ++ +   +  L+  +
Sbjct: 927  HQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV 986

Query: 561  KDRDEEIQKLRNQLTNKTLSNSSQSE----LENRLHQLTETLIQKQTMLESLSTEKNSLV 616
              + E   KL+ QLT      +++ E    L+N   +  ET  Q Q+      +E  +  
Sbjct: 987  LQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATR 1046

Query: 617  FQLERLEQQMNSA 629
              L+ +E++++ A
Sbjct: 1047 QDLKSVEEKLSLA 1059



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 101/515 (19%), Positives = 205/515 (39%), Gaps = 67/515 (13%)

Query: 146 KTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEE--SSKENVS 203
           KT + Q      V+ +   +  ++T+ +N    +  E+    D   + Q +  SS+  +S
Sbjct: 211 KTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATIS 270

Query: 204 SNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKAR 263
              +               EL+    E  +   E+Q L   +  L Q+++   E L K  
Sbjct: 271 QLRS---------------ELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKE 315

Query: 264 ARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALE 323
               K    H++     + ++A +           S+L+  +  L      LS + EA +
Sbjct: 316 QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQ 375

Query: 324 ALQSEKSRI-------------------------MQDQSEGNSLQNQALQTFQERLHEAD 358
            L+ E S +                         +Q QSE N L ++ L+T + +L EA 
Sbjct: 376 KLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET-ERQLGEAH 434

Query: 359 ATLKREQE--SYKQMQSEFAARLNKVEMER--QNLAEAITLAERKYSDEKKRVDELQQQV 414
             LK +++  S K M  E      ++++ R  + L E +T +        K   + Q+Q 
Sbjct: 435 GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQ 494

Query: 415 KLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHE 474
            L +      ++   D +Q   +I    +K+ N        E L   +  ++ L E   E
Sbjct: 495 ALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN-------LEALLQKSKENISLLEKERE 547

Query: 475 K--------EMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKA 526
                    E +   + +L  + H L+ ++  +  +  N++ES ++  ++LHDQ+  QKA
Sbjct: 548 DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKA 607

Query: 527 SKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQ-KLRNQLTNKTLSNSSQS 585
             +  +  +  L+   + +   L    N  + ++   D +I+ K    L+ +    + ++
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQL----NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA 663

Query: 586 ELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLE 620
           +L+N L      L  KQ  L  ++T+ + +  +L+
Sbjct: 664 DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ 698



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 88/410 (21%), Positives = 168/410 (40%), Gaps = 59/410 (14%)

Query: 237 EVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAA 296
           +VQ+L   M   L+R +E++    K +   +K  + ++ S+     LR+++    + VA 
Sbjct: 232 QVQTLMDNMT--LERERESE----KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAV 285

Query: 297 KDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHE 356
              +L  LK  + E  Q   T TE L   + + +++ +  +E    ++ + +  Q  LH+
Sbjct: 286 YVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNE----ESVSKKNIQATLHQ 341

Query: 357 ADATLKREQESYKQMQSEFAAR---LNKVEME-------RQNLAEAITLAERKYSDEKKR 406
            D   +       Q+QS  +A    L+++ +E        Q L E ++  E KY   K  
Sbjct: 342 KDLDCQ-------QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAE 394

Query: 407 VDELQQQ---VKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTA 463
             +LQQQ    + + L L+S   +L     +  R L      +   ++ S  + +D    
Sbjct: 395 FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQ 454

Query: 464 SS------MELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDL 517
            +        LEE   EK     E+Q  + +  Q   E Q ++     +   A+  L+ +
Sbjct: 455 VADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQV 514

Query: 518 HDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNK 577
             QI  +    Q LE  L++ K+    +E              K+R++   K++      
Sbjct: 515 LRQIGDKDQKIQNLEALLQKSKENISLLE--------------KEREDLYAKIQ------ 554

Query: 578 TLSNSSQSELENRLHQLTETLIQKQTML-ESLSTEKNSLVFQLERLEQQM 626
             +   ++ + N+L +   TL ++ T L E L  +  S     E L  Q+
Sbjct: 555 --AGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV 602


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 92/411 (22%), Positives = 182/411 (44%), Gaps = 55/411 (13%)

Query: 246  ASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVL- 304
            A L  + ++ ++E ++ +  ++      +K ++       +V +LTE +A  D  +A L 
Sbjct: 940  AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLT 999

Query: 305  --KVRLQEADQL----LSTRTEALEALQSEKSRIMQ--DQSEGNSLQNQALQTFQERL-H 355
              K  LQEA Q     L    + +  L   K ++ Q  D  EG+  Q + L+   ER   
Sbjct: 1000 KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKR 1059

Query: 356  EADATLKREQESYKQMQSE---FAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQ 412
            + +  LK  QES   +++E      +L K E E  NL   I   +      +K++ ELQ 
Sbjct: 1060 KLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQA 1119

Query: 413  QVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELR 472
            +++  +  +E+ +      +++ + + +  E++   L+E  G      +T++ +E+ + R
Sbjct: 1120 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG------ATSAQIEMNKKR 1173

Query: 473  HEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELE 532
             E E Q+            +R +L++   Q    A + R++  D   ++  Q  + Q ++
Sbjct: 1174 -EAEFQK------------MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1220

Query: 533  TELERLKQEFHYIEEDL-----------------YRTKNTLQSRIKDRDEEIQKLRNQLT 575
             +LE+ K E     +DL                  RT     S +K ++EE Q+L N LT
Sbjct: 1221 QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280

Query: 576  NKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQM 626
                  + +  L+    + +  L +K+ ++  LS  K +   Q+E L++Q+
Sbjct: 1281 ------AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL 1325



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 106/504 (21%), Positives = 215/504 (42%), Gaps = 64/504 (12%)

Query: 192  EGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQL--LRNEVQSLNQEMASLL 249
            E  EE+ K+      A  +H    N    S E +  RL+N++  L  +V+  N   A+L 
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD 1449

Query: 250  QRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQ 309
            ++ +   + L + + + E+ +A+   S +  R L  ++  +  A      QL  LK   +
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENK 1509

Query: 310  EADQLLSTRTEAL-------EALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLK 362
               Q +S  TE +         L+  K ++ Q++ E            Q  L EA+A+L+
Sbjct: 1510 NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE-----------LQAALEEAEASLE 1558

Query: 363  REQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQ----VKLYK 418
             E+    ++Q E    LN+V+ E           +RK +++ + +D+L++     V+  +
Sbjct: 1559 HEEGKILRIQLE----LNQVKSE----------VDRKIAEKDEEIDQLKRNHIRIVESMQ 1604

Query: 419  LNLES---SKQELIDYKQKATRILQSKEKLIN--------SLKEGSGFEGLDSSTASSME 467
              L++   S+ + I  K+K    L   E  +N        +L+     +G+   T   ++
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD 1664

Query: 468  -----LEELRHEKEMQREEIQKLMGQIHQLRSELQDME-AQQVNEAE--SAREQLQDLHD 519
                  E+L+ +  M       L  +I +LR+ L+  E ++++ E E   A E++Q LH 
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1724

Query: 520  QIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTL 579
            Q      +K++LET++ +++ E     ED+ +     + + K    +   +  +L  +  
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEM----EDILQEARNAEEKAKKAITDAAMMAEELKKEQD 1780

Query: 580  SNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSI 639
            +++    ++  + Q  + L  +    E L+ +      Q+++LE ++    G   +    
Sbjct: 1781 TSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK--QIQKLEARVRELEGEVESEQKR 1838

Query: 640  NMSGIDNGEGTRLRNVPVLFNDTE 663
            N   +  G     R V  L   TE
Sbjct: 1839 NAEAV-KGLRKHERRVKELTYQTE 1861



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 93/561 (16%), Positives = 218/561 (38%), Gaps = 80/561 (14%)

Query: 139  EIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEESS 198
            ++ KEK  T     + T  ++ ++ ++   K  +E     + H+   +     + Q E  
Sbjct: 969  KVEKEKHATENKVKNLTEEMAGLDETIA--KLTKEKKALQEAHQQTLD-----DLQAEED 1021

Query: 199  KENVSSNAACPDHTPTPNDDGKSHELSNLRLENQ-----------LLRNEVQSLNQEMAS 247
            K N  + A         + +G   +   LR++ +           L +  +  +  E   
Sbjct: 1022 KVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQ 1081

Query: 248  LLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDS-------- 299
            L ++ K+ + E++  ++++E   A   +  +  + L+A++++L E + A+ +        
Sbjct: 1082 LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1141

Query: 300  ------QLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQER 353
                  +L  +  RL+EA    S + E  +  ++E  ++ +D  E          T +++
Sbjct: 1142 RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1201

Query: 354  LHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQ 413
              ++ A L  + ++ ++++ +     ++++ME  +LA  +    +   + +K    L+ Q
Sbjct: 1202 HADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261

Query: 414  VKLYKLNLESSKQELIDYKQKATRI----------LQSKEKLINSLKEGSGF-------- 455
            +   K   E  ++ + D   +  R+          L  KE L++ L  G           
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321

Query: 456  -----EGLDSSTASSMELEELRHEKEMQRE----------EIQKLMGQIH---------- 490
                 E + +  A +  L+  RH+ ++ RE          E+Q+ + + +          
Sbjct: 1322 KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY 1381

Query: 491  -----QLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYI 545
                 Q   EL++ + +     ++A E ++ ++ + A  + +KQ L+ E+E L  +    
Sbjct: 1382 ETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERT 1441

Query: 546  EEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTML 605
                       ++  K   E  QK          S      L   L ++     +    L
Sbjct: 1442 NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQL 1501

Query: 606  ESLSTEKNSLVFQLERLEQQM 626
            E+L  E  +L  ++  L +Q+
Sbjct: 1502 ETLKRENKNLQQEISDLTEQI 1522



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 88/399 (22%), Positives = 180/399 (45%), Gaps = 80/399 (20%)

Query: 249  LQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQV-------DDLTEAVAAKDSQL 301
            L +S ET++E+   +   +K   + +KS+   + L  ++       +DL   V A+   L
Sbjct: 845  LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904

Query: 302  AVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATL 361
            A  + R    DQL+ T+ + LEA   E +   +D+ E N+     L   + +L +  + L
Sbjct: 905  ADAEER---CDQLIKTKIQ-LEAKIKEVTERAEDEEEINA----ELTAKKRKLEDECSEL 956

Query: 362  KREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNL 421
            K++ +       +    L KVE E+      +    +  ++E   +DE   ++   K  L
Sbjct: 957  KKDID-------DLELTLAKVEKEKHATENKV----KNLTEEMAGLDETIAKLTKEKKAL 1005

Query: 422  ESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREE 481
            + + Q+ +D        LQ++E  +N+L            T + ++LE+       Q ++
Sbjct: 1006 QEAHQQTLDD-------LQAEEDKVNTL------------TKAKIKLEQ-------QVDD 1039

Query: 482  IQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQE 541
            ++  + Q  +LR +L+  + +   + + A+E + D+ ++       KQ+L+ +L+  K+E
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENE-------KQQLDEKLK--KKE 1090

Query: 542  FHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQK 601
            F           + LQS+I+D     Q L  QL  K        EL+ R+ +L E +  +
Sbjct: 1091 FEI---------SNLQSKIEDE----QALGIQLQKKI------KELQARIEELEEEIEAE 1131

Query: 602  QTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSIN 640
            +        +++ L  +LE + +++  A G++S    +N
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1170



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 82/372 (22%), Positives = 159/372 (42%), Gaps = 51/372 (13%)

Query: 220  KSHELSNLRLENQLLRNEVQS-LNQEMAS---LLQRSKETQEELNKARARVEKWN---AD 272
            K  E+  L+  +  +   +QS L+ E+ S    ++  K+ + +LN+   ++   N   A+
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1644

Query: 273  HSKSDRMTRGL----RAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEAL--Q 326
              ++ R T+G+    +  +DD   +      QLA+++ R      LL    E L A   Q
Sbjct: 1645 ALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRAN----LLQAEIEELRATLEQ 1700

Query: 327  SEKSRIMQDQSEGNSLQN-QALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEME 385
            +E+SR + +Q   ++ +  Q L T    L     T K+ +    QMQ E    L +    
Sbjct: 1701 TERSRKIAEQELLDASERVQLLHTQNTSLIN---TKKKLETDISQMQGEMEDILQEARNA 1757

Query: 386  RQNLAEAITLAERKYSDEKKRVD----------ELQQQVKLYKLNLESSKQELIDYKQKA 435
             +   +AIT A     + KK  D           ++Q VK  +L L+ ++Q  +   +K 
Sbjct: 1758 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQ 1817

Query: 436  TRILQSKEKLINSLKEGS---GFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQL 492
             + L+++ + +    E       E +         ++EL ++ E  R+ I +L   + +L
Sbjct: 1818 IQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKL 1877

Query: 493  RSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRT 552
            +++++  + Q    AE A EQ            A  ++L+ ELE  ++     E  + + 
Sbjct: 1878 QAKVKSYKRQ----AEEAEEQSNT-------NLAKFRKLQHELEEAEERADIAESQVNKL 1926

Query: 553  KNTLQSRIKDRD 564
                  R+K R+
Sbjct: 1927 ------RVKSRE 1932



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 41/202 (20%), Positives = 89/202 (44%), Gaps = 21/202 (10%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKA-------RARVEKWNADHSKSDRMTRGLRAQ 286
            L  ++  +  EM  +LQ ++  +E+  KA          ++K     +  +RM + +   
Sbjct: 1736 LETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1795

Query: 287  VDDL------TEAVAAKDS--QLAVLKVRLQEADQLLSTR----TEALEALQSEKSRIMQ 334
            V DL       E +A K    Q+  L+ R++E +  + +      EA++ L+  + R+ +
Sbjct: 1796 VKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE 1855

Query: 335  --DQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEA 392
               Q+E +      LQ   ++L     + KR+ E  ++  +   A+  K++ E +   E 
Sbjct: 1856 LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEER 1915

Query: 393  ITLAERKYSDEKKRVDELQQQV 414
              +AE + +  + +  E+  +V
Sbjct: 1916 ADIAESQVNKLRVKSREVHTKV 1937



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 53/233 (22%), Positives = 103/233 (44%), Gaps = 30/233 (12%)

Query: 409  ELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMEL 468
            E ++++   K   +  K EL   + K   +   +EK++  LKE +  +    + A  +  
Sbjct: 850  ETEKEMATMKEEFQKIKDELAKSEAKRKEL---EEKMVTLLKEKNDLQLQVQAEAEGLAD 906

Query: 469  EELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASK 528
             E R + ++ + +IQ L  +I ++    +D E  ++N   +A+++   L D+ +  K   
Sbjct: 907  AEERCD-QLIKTKIQ-LEAKIKEVTERAEDEE--EINAELTAKKR--KLEDECSELKKDI 960

Query: 529  QELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELE 588
             +LE  L ++++E H  E    + KN L   +   DE I KL  +   K L  + Q  L+
Sbjct: 961  DDLELTLAKVEKEKHATEN---KVKN-LTEEMAGLDETIAKLTKE--KKALQEAHQQTLD 1014

Query: 589  NRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINM 641
            +               L++   + N+L     +LEQQ++   GS      + M
Sbjct: 1015 D---------------LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM 1052


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 92/411 (22%), Positives = 182/411 (44%), Gaps = 55/411 (13%)

Query: 246  ASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVL- 304
            A L  + ++ ++E ++ +  ++      +K ++       +V +LTE +A  D  +A L 
Sbjct: 940  AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLT 999

Query: 305  --KVRLQEADQL----LSTRTEALEALQSEKSRIMQ--DQSEGNSLQNQALQTFQERL-H 355
              K  LQEA Q     L    + +  L   K ++ Q  D  EG+  Q + L+   ER   
Sbjct: 1000 KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKR 1059

Query: 356  EADATLKREQESYKQMQSE---FAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQ 412
            + +  LK  QES   +++E      +L K E E  NL   I   +      +K++ ELQ 
Sbjct: 1060 KLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQA 1119

Query: 413  QVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELR 472
            +++  +  +E+ +      +++ + + +  E++   L+E  G      +T++ +E+ + R
Sbjct: 1120 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG------ATSAQIEMNKKR 1173

Query: 473  HEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELE 532
             E E Q+            +R +L++   Q    A + R++  D   ++  Q  + Q ++
Sbjct: 1174 -EAEFQK------------MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1220

Query: 533  TELERLKQEFHYIEEDL-----------------YRTKNTLQSRIKDRDEEIQKLRNQLT 575
             +LE+ K E     +DL                  RT     S +K ++EE Q+L N LT
Sbjct: 1221 QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280

Query: 576  NKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQM 626
                  + +  L+    + +  L +K+ ++  LS  K +   Q+E L++Q+
Sbjct: 1281 ------AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL 1325



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 106/504 (21%), Positives = 215/504 (42%), Gaps = 64/504 (12%)

Query: 192  EGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQL--LRNEVQSLNQEMASLL 249
            E  EE+ K+      A  +H    N    S E +  RL+N++  L  +V+  N   A+L 
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD 1449

Query: 250  QRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQ 309
            ++ +   + L + + + E+ +A+   S +  R L  ++  +  A      QL  LK   +
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENK 1509

Query: 310  EADQLLSTRTEAL-------EALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLK 362
               Q +S  TE +         L+  K ++ Q++ E            Q  L EA+A+L+
Sbjct: 1510 NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE-----------LQAALEEAEASLE 1558

Query: 363  REQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQ----VKLYK 418
             E+    ++Q E    LN+V+ E           +RK +++ + +D+L++     V+  +
Sbjct: 1559 HEEGKILRIQLE----LNQVKSE----------VDRKIAEKDEEIDQLKRNHIRIVESMQ 1604

Query: 419  LNLES---SKQELIDYKQKATRILQSKEKLIN--------SLKEGSGFEGLDSSTASSME 467
              L++   S+ + I  K+K    L   E  +N        +L+     +G+   T   ++
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD 1664

Query: 468  -----LEELRHEKEMQREEIQKLMGQIHQLRSELQDME-AQQVNEAE--SAREQLQDLHD 519
                  E+L+ +  M       L  +I +LR+ L+  E ++++ E E   A E++Q LH 
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1724

Query: 520  QIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTL 579
            Q      +K++LET++ +++ E     ED+ +     + + K    +   +  +L  +  
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEM----EDILQEARNAEEKAKKAITDAAMMAEELKKEQD 1780

Query: 580  SNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSI 639
            +++    ++  + Q  + L  +    E L+ +      Q+++LE ++    G   +    
Sbjct: 1781 TSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK--QIQKLEARVRELEGEVESEQKR 1838

Query: 640  NMSGIDNGEGTRLRNVPVLFNDTE 663
            N   +  G     R V  L   TE
Sbjct: 1839 NAEAV-KGLRKHERRVKELTYQTE 1861



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 93/561 (16%), Positives = 218/561 (38%), Gaps = 80/561 (14%)

Query: 139  EIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEESS 198
            ++ KEK  T     + T  ++ ++ ++   K  +E     + H+   +     + Q E  
Sbjct: 969  KVEKEKHATENKVKNLTEEMAGLDETIA--KLTKEKKALQEAHQQTLD-----DLQAEED 1021

Query: 199  KENVSSNAACPDHTPTPNDDGKSHELSNLRLENQ-----------LLRNEVQSLNQEMAS 247
            K N  + A         + +G   +   LR++ +           L +  +  +  E   
Sbjct: 1022 KVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQ 1081

Query: 248  LLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDS-------- 299
            L ++ K+ + E++  ++++E   A   +  +  + L+A++++L E + A+ +        
Sbjct: 1082 LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1141

Query: 300  ------QLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQER 353
                  +L  +  RL+EA    S + E  +  ++E  ++ +D  E          T +++
Sbjct: 1142 RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1201

Query: 354  LHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQ 413
              ++ A L  + ++ ++++ +     ++++ME  +LA  +    +   + +K    L+ Q
Sbjct: 1202 HADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261

Query: 414  VKLYKLNLESSKQELIDYKQKATRI----------LQSKEKLINSLKEGSGF-------- 455
            +   K   E  ++ + D   +  R+          L  KE L++ L  G           
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321

Query: 456  -----EGLDSSTASSMELEELRHEKEMQRE----------EIQKLMGQIH---------- 490
                 E + +  A +  L+  RH+ ++ RE          E+Q+ + + +          
Sbjct: 1322 KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY 1381

Query: 491  -----QLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYI 545
                 Q   EL++ + +     ++A E ++ ++ + A  + +KQ L+ E+E L  +    
Sbjct: 1382 ETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERT 1441

Query: 546  EEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTML 605
                       ++  K   E  QK          S      L   L ++     +    L
Sbjct: 1442 NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQL 1501

Query: 606  ESLSTEKNSLVFQLERLEQQM 626
            E+L  E  +L  ++  L +Q+
Sbjct: 1502 ETLKRENKNLQQEISDLTEQI 1522



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 88/399 (22%), Positives = 180/399 (45%), Gaps = 80/399 (20%)

Query: 249  LQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQV-------DDLTEAVAAKDSQL 301
            L +S ET++E+   +   +K   + +KS+   + L  ++       +DL   V A+   L
Sbjct: 845  LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904

Query: 302  AVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATL 361
            A  + R    DQL+ T+ + LEA   E +   +D+ E N+     L   + +L +  + L
Sbjct: 905  ADAEER---CDQLIKTKIQ-LEAKIKEVTERAEDEEEINA----ELTAKKRKLEDECSEL 956

Query: 362  KREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNL 421
            K++ +       +    L KVE E+      +    +  ++E   +DE   ++   K  L
Sbjct: 957  KKDID-------DLELTLAKVEKEKHATENKV----KNLTEEMAGLDETIAKLTKEKKAL 1005

Query: 422  ESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREE 481
            + + Q+ +D        LQ++E  +N+L            T + ++LE+       Q ++
Sbjct: 1006 QEAHQQTLDD-------LQAEEDKVNTL------------TKAKIKLEQ-------QVDD 1039

Query: 482  IQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQE 541
            ++  + Q  +LR +L+  + +   + + A+E + D+ ++       KQ+L+ +L+  K+E
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENE-------KQQLDEKLK--KKE 1090

Query: 542  FHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQK 601
            F           + LQS+I+D     Q L  QL  K        EL+ R+ +L E +  +
Sbjct: 1091 FEI---------SNLQSKIEDE----QALGIQLQKKI------KELQARIEELEEEIEAE 1131

Query: 602  QTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSIN 640
            +        +++ L  +LE + +++  A G++S    +N
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1170



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 82/372 (22%), Positives = 159/372 (42%), Gaps = 51/372 (13%)

Query: 220  KSHELSNLRLENQLLRNEVQS-LNQEMAS---LLQRSKETQEELNKARARVEKWN---AD 272
            K  E+  L+  +  +   +QS L+ E+ S    ++  K+ + +LN+   ++   N   A+
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1644

Query: 273  HSKSDRMTRGL----RAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEAL--Q 326
              ++ R T+G+    +  +DD   +      QLA+++ R      LL    E L A   Q
Sbjct: 1645 ALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRAN----LLQAEIEELRATLEQ 1700

Query: 327  SEKSRIMQDQSEGNSLQN-QALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEME 385
            +E+SR + +Q   ++ +  Q L T    L     T K+ +    QMQ E    L +    
Sbjct: 1701 TERSRKIAEQELLDASERVQLLHTQNTSLIN---TKKKLETDISQMQGEMEDILQEARNA 1757

Query: 386  RQNLAEAITLAERKYSDEKKRVD----------ELQQQVKLYKLNLESSKQELIDYKQKA 435
             +   +AIT A     + KK  D           ++Q VK  +L L+ ++Q  +   +K 
Sbjct: 1758 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQ 1817

Query: 436  TRILQSKEKLINSLKEGS---GFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQL 492
             + L+++ + +    E       E +         ++EL ++ E  R+ I +L   + +L
Sbjct: 1818 IQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKL 1877

Query: 493  RSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRT 552
            +++++  + Q    AE A EQ            A  ++L+ ELE  ++     E  + + 
Sbjct: 1878 QAKVKSYKRQ----AEEAEEQSNT-------NLAKFRKLQHELEEAEERADIAESQVNKL 1926

Query: 553  KNTLQSRIKDRD 564
                  R+K R+
Sbjct: 1927 ------RVKSRE 1932



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 41/202 (20%), Positives = 89/202 (44%), Gaps = 21/202 (10%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKA-------RARVEKWNADHSKSDRMTRGLRAQ 286
            L  ++  +  EM  +LQ ++  +E+  KA          ++K     +  +RM + +   
Sbjct: 1736 LETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1795

Query: 287  VDDL------TEAVAAKDS--QLAVLKVRLQEADQLLSTR----TEALEALQSEKSRIMQ 334
            V DL       E +A K    Q+  L+ R++E +  + +      EA++ L+  + R+ +
Sbjct: 1796 VKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE 1855

Query: 335  --DQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEA 392
               Q+E +      LQ   ++L     + KR+ E  ++  +   A+  K++ E +   E 
Sbjct: 1856 LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEER 1915

Query: 393  ITLAERKYSDEKKRVDELQQQV 414
              +AE + +  + +  E+  +V
Sbjct: 1916 ADIAESQVNKLRVKSREVHTKV 1937



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 53/233 (22%), Positives = 103/233 (44%), Gaps = 30/233 (12%)

Query: 409  ELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMEL 468
            E ++++   K   +  K EL   + K   +   +EK++  LKE +  +    + A  +  
Sbjct: 850  ETEKEMATMKEEFQKIKDELAKSEAKRKEL---EEKMVTLLKEKNDLQLQVQAEAEGLAD 906

Query: 469  EELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASK 528
             E R + ++ + +IQ L  +I ++    +D E  ++N   +A+++   L D+ +  K   
Sbjct: 907  AEERCD-QLIKTKIQ-LEAKIKEVTERAEDEE--EINAELTAKKR--KLEDECSELKKDI 960

Query: 529  QELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELE 588
             +LE  L ++++E H  E    + KN L   +   DE I KL  +   K L  + Q  L+
Sbjct: 961  DDLELTLAKVEKEKHATEN---KVKN-LTEEMAGLDETIAKLTKE--KKALQEAHQQTLD 1014

Query: 589  NRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINM 641
            +               L++   + N+L     +LEQQ++   GS      + M
Sbjct: 1015 D---------------LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM 1052


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 117/572 (20%), Positives = 230/572 (40%), Gaps = 96/572 (16%)

Query: 139  EIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEESS 198
            ++ KEK  T     + T  ++ ++  +   K  +E     + H+ A +     + Q E  
Sbjct: 963  KVEKEKHATENKVKNLTEEMAGLDEIIA--KLTKEKKALQEAHQQALD-----DLQAEED 1015

Query: 199  KENVSSNAACPDHTPTPNDDGKSHELSNLRLENQ-----------LLRNEVQSLNQEMAS 247
            K N  + A         + +G   +   +R++ +           L +  +  L  +   
Sbjct: 1016 KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQ 1075

Query: 248  LLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAK---------- 297
            L +R K+   ELN   AR+E   A  S+  +  + L+A++++L E + A+          
Sbjct: 1076 LDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKL 1135

Query: 298  ----DSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQER 353
                  +L  +  RL+EA    S + E  +  ++E  ++ +D  E  +LQ++A      +
Sbjct: 1136 RSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEA-TLQHEATAAALRK 1194

Query: 354  LH--------EADATLKREQESYKQMQSEFAARLNKV--EME-----RQNLAEAITLAER 398
             H        E    L+R ++  ++ +SEF   L+ V   ME     + NL +     E 
Sbjct: 1195 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 1254

Query: 399  KYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGF--- 455
            + ++ + + +E Q+ V     +L S + +L     + +R L  KE LI+ L  G      
Sbjct: 1255 QMNEHRSKAEETQRSVN----DLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQ 1310

Query: 456  ----------EGLDSSTASSMELEELRHEKEMQREE--------------IQKLMGQIHQ 491
                      E + +  A +  L+  RH+ ++ RE+              + K   ++ Q
Sbjct: 1311 QLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ 1370

Query: 492  LRSELQDMEAQQVNEAESAR----EQLQDLHDQIAGQKASKQELETELERLKQEFHYIEE 547
             R++ +    Q+  E E A+    ++LQ+  + +    A    LE    RL+ E   +  
Sbjct: 1371 WRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV 1430

Query: 548  DLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELEN----------RLHQLTET 597
            D+ R+ N   + +  +     K+  +   K     SQSELE+           L +L   
Sbjct: 1431 DVERS-NAAAAALDKKQRNFDKILAEWKQK--YEESQSELESSQKEARSLSTELFKLKNA 1487

Query: 598  LIQKQTMLESLSTEKNSLVFQLERLEQQMNSA 629
              +    LE+   E  +L  ++  L +Q+ S+
Sbjct: 1488 YEESLEHLETFKRENKNLQEEISDLTEQLGSS 1519



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 89/426 (20%), Positives = 182/426 (42%), Gaps = 61/426 (14%)

Query: 243  QEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLA 302
            +EMAS+       +EE  + +  +EK  A   + +     L  + +DL   V A+   LA
Sbjct: 847  KEMASM-------KEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA 899

Query: 303  VLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLK 362
              + R    DQL+  + + LEA   E +  ++D+ E     N  L   + +L +  + LK
Sbjct: 900  DAEER---CDQLIKNKIQ-LEAKVKEMNERLEDEEE----MNAELTAKKRKLEDECSELK 951

Query: 363  REQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLE 422
            R+ +       +    L KVE E+      +    +  ++E   +DE+  ++   K  L+
Sbjct: 952  RDID-------DLELTLAKVEKEKHATENKV----KNLTEEMAGLDEIIAKLTKEKKALQ 1000

Query: 423  SSKQELIDYKQ----KATRILQSKEKLINSLKEGSGFEGLDSSTASSMELE--------- 469
             + Q+ +D  Q    K   + ++K KL   + +  G   L+      M+LE         
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEG--SLEQEKKVRMDLERAKRKLEGD 1058

Query: 470  ---------ELRHEKEMQREEIQKLMGQIHQLRSELQDMEA---QQVNEAESAREQLQDL 517
                     +L ++K+   E ++K   +++ L + ++D +A   Q   + +  + ++++L
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118

Query: 518  HDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRI---KDRDEEIQKLRNQL 574
             +++  ++ ++ ++E     L +E   I E L         +I   K R+ E QK+R  L
Sbjct: 1119 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1178

Query: 575  TNKTLSNSSQSELENRLH-----QLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSA 629
               TL + + +    + H     +L E +   Q + + L  EK+    +L+ +   M   
Sbjct: 1179 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI 1238

Query: 630  SGSSSN 635
              + +N
Sbjct: 1239 IKAKAN 1244



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 105/537 (19%), Positives = 221/537 (41%), Gaps = 72/537 (13%)

Query: 158  VSSVNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPND 217
            +S  N  V   +T  E     +T E         +  +E+ +   + NA C     T + 
Sbjct: 1361 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR 1420

Query: 218  DGKSHELSNLRLENQ-------LLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWN 270
                +E+ +L ++ +        L  + ++ ++ +A   Q+ +E+Q EL  ++      +
Sbjct: 1421 --LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLS 1478

Query: 271  ADHSKSD--------------RMTRGLRAQVDDLTEAVAAKDSQLAVL-KVRLQ---EAD 312
             +  K                R  + L+ ++ DLTE + +    +  L KVR Q   E  
Sbjct: 1479 TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKM 1538

Query: 313  QLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQ 372
            +L S   EA  +L+ E+ +I++ Q E N ++ +  +   E+  E +   +        +Q
Sbjct: 1539 ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQ 1598

Query: 373  SEFAARL----------NKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLE 422
            +   A             K+E +   +   ++ A R  ++ +K+V  LQ  +K  ++ L+
Sbjct: 1599 TSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLD 1658

Query: 423  SSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEI 482
             + +   D K+    + +    L   L+E      +   T  S +L E    +  +R ++
Sbjct: 1659 DAVRANDDLKENIAIVERRNNLLQAELEE---LRAVVEQTERSRKLAEQELIETSERVQL 1715

Query: 483  ------------QKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQE 530
                        +K+   + QL++E+++   +  N  E A++ + D    +A +   +Q+
Sbjct: 1716 LHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDA-AMMAEELKKEQD 1774

Query: 531  LETELERLKQEFHYIEEDL-YRTKNTLQSRIKDRDEEIQK-------LRNQLTNKTLSNS 582
                LER+K+      +DL +R     Q  +K   +++QK       L N+L  +   N+
Sbjct: 1775 TSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1834

Query: 583  ----SQSELENRLHQLT-------ETLIQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
                   + E R+ +LT       + L++ Q +++ L  +  +   Q E  E+Q N+
Sbjct: 1835 ESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANT 1891



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 97/454 (21%), Positives = 199/454 (43%), Gaps = 47/454 (10%)

Query: 192  EGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQ--LLRNEVQSLNQEMASL- 248
            E +EE + E  +      D       D    EL+  ++E +     N+V++L +EMA L 
Sbjct: 927  EDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 986

Query: 249  -----LQRSKETQEELNKARARVEKWNADHSKSDRMTRG---LRAQVDDLTEAVAAKDSQ 300
                 L + K+  +E +  +  ++   A+  K + +T+    L  QVDDL  ++  +   
Sbjct: 987  EIIAKLTKEKKALQEAH--QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKV 1044

Query: 301  LAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADAT 360
               L+   ++ +  L    E++  L+++K    Q   E    ++  L     R+ +  A 
Sbjct: 1045 RMDLERAKRKLEGDLKLTQESIMDLENDK----QQLDERLKKKDFELNALNARIEDEQAL 1100

Query: 361  LKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVK----L 416
              + Q+  K++Q    AR+ ++E E +    A    E+  SD  + ++E+ ++++     
Sbjct: 1101 GSQLQKKLKELQ----ARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGA 1156

Query: 417  YKLNLESSKQELIDYKQKATRILQS------------KEKLINSLKEGSGFEGLDSSTAS 464
              + +E +K+   ++ QK  R L+             ++K  +S+ E    E +D+    
Sbjct: 1157 TSVQIEMNKKREAEF-QKMRRDLEEATLQHEATAAALRKKHADSVAELG--EQIDNLQRV 1213

Query: 465  SMELEELRHEKEMQREEIQKLMGQIHQLRSELQDM---EAQQVNEAESAREQLQDLHDQI 521
              +LE+ + E +++ +++   M QI + ++ L+ M      Q+NE  S  E+ Q   + +
Sbjct: 1214 KQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDL 1273

Query: 522  AGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQ---KLRNQLTNKT 578
              Q+A  Q    EL R   E   +   L R K T   +++D   +++   K +N L +  
Sbjct: 1274 TSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHAL 1333

Query: 579  LSNSSQSE-LENRLHQLTETLIQKQTMLESLSTE 611
             S     + L  +  + TE   + Q +L   ++E
Sbjct: 1334 QSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1367



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 94/489 (19%), Positives = 201/489 (41%), Gaps = 56/489 (11%)

Query: 34   NIYSKNTDYTE--------LHQQNTDLIYQTGPKSTYISSAADNIRNQKATILAGTANVK 85
            N Y ++ ++ E        L ++ +DL  Q G     I    + +R Q    L       
Sbjct: 1486 NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHEL-EKVRKQ----LEAEKMEL 1540

Query: 86   VGSRTPVEASHPVENASVPRPSSHF------VRRKKSEPDDELLFDFLNSSQKEPTGRVE 139
              +    EAS   E   + R    F      + RK +E D+E+          E   R  
Sbjct: 1541 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEM----------EQAKRNH 1590

Query: 140  IRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEESSK 199
            +R         Q+S  +   S N ++   K +E +    +   + +N  ++   ++  S 
Sbjct: 1591 LRVVDS----LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSL 1646

Query: 200  ENVSSNAACP-DHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEE 258
            +++  +     D     NDD K + ++ +   N LL+ E++ L   +    +  K  ++E
Sbjct: 1647 QSLLKDTQIQLDDAVRANDDLKEN-IAIVERRNNLLQAELEELRAVVEQTERSRKLAEQE 1705

Query: 259  LNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTR 318
            L +   RV+     HS++  +    +    DL++     +  +   +   ++A + ++  
Sbjct: 1706 LIETSERVQLL---HSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDA 1762

Query: 319  TEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADA-TLKREQESYKQMQSEFAA 377
                E L+ E+      +    +++ Q ++  Q RL EA+   LK  ++  +++++    
Sbjct: 1763 AMMAEELKKEQDTSAHLERMKKNME-QTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1821

Query: 378  RLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATR 437
              N++E E++  AE++    +     ++R+ EL  Q +  + NL    Q+L+D       
Sbjct: 1822 LENELEAEQKRNAESV----KGMRKSERRIKELTYQTEEDRKNL-LRLQDLVDK------ 1870

Query: 438  ILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQ 497
             LQ K K      E    E  + +  +  +  +++HE +   E       Q+++LR++ +
Sbjct: 1871 -LQLKVKAYKRQAE----EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1925

Query: 498  DMEAQQVNE 506
            D+  + +NE
Sbjct: 1926 DIGTKGLNE 1934



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 63/287 (21%), Positives = 135/287 (47%), Gaps = 47/287 (16%)

Query: 373  SEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYK 432
            +E    +  ++ E   L EA+  +E +  + ++++  L Q+    +L +++ +  L D +
Sbjct: 843  AEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAE 902

Query: 433  QKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQRE---EIQKLMGQI 489
            ++  +++++K +L   +KE +               E L  E+EM  E   + +KL  + 
Sbjct: 903  ERCDQLIKNKIQLEAKVKEMN---------------ERLEDEEEMNAELTAKKRKLEDEC 947

Query: 490  HQLRSELQDME---AQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFH--- 543
             +L+ ++ D+E   A+   E  +   ++++L +++AG      +L  E + L QE H   
Sbjct: 948  SELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL-QEAHQQA 1006

Query: 544  ----YIEED----LYRTKNTLQSRIKDRD---EEIQKLRNQLT--------NKTLSNSSQ 584
                  EED    L + K  L+ ++ D +   E+ +K+R  L         +  L+  S 
Sbjct: 1007 LDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1066

Query: 585  SELENRLHQLTETLIQKQTMLESLST---EKNSLVFQLERLEQQMNS 628
             +LEN   QL E L +K   L +L+    ++ +L  QL++  +++ +
Sbjct: 1067 MDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 1113



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 64/286 (22%), Positives = 118/286 (41%), Gaps = 41/286 (14%)

Query: 383  EMERQNLAEAIT---------LAERKYSDEKKRVDEL---QQQVKLYKLNLESSKQELID 430
            EM  + L+  IT         LA  +Y    +R D L   Q  ++ + + +++     + 
Sbjct: 775  EMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAF-MGVKNWPWMKLY 833

Query: 431  YKQKATRILQSKEKLINSLKEGSGF--EGLDSSTASSMELEEL-------RHEKEMQREE 481
            +K K       +EK + S+KE      E L+ S A   ELEE        +++ ++Q + 
Sbjct: 834  FKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893

Query: 482  IQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQE 541
             Q  +    +   +L   + Q   + +   E+L+D  +  A   A K++LE E   LK++
Sbjct: 894  EQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRD 953

Query: 542  FHYIEEDLYRT---KNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETL 598
               +E  L +    K+  ++++K+  EE+  L   +   T    +  E            
Sbjct: 954  IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH---------- 1003

Query: 599  IQKQTMLESLSTEK---NSLVFQLERLEQQMNSASGSSSNGSSINM 641
               Q  L+ L  E+   N+L     +LEQQ++   GS      + M
Sbjct: 1004 ---QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRM 1046


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 120/533 (22%), Positives = 227/533 (42%), Gaps = 92/533 (17%)

Query: 182  EAASNSDSSHEGQEESSKENV------SSNAACPDHTPTPNDDGKSH--ELSNLRLENQL 233
            E +S  D + E QE+ S E +      S  A       T       H  EL   RLE + 
Sbjct: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEA 293
              +EV  LN  +AS  ++S+E Q  L K +A++           R     + +++DL  +
Sbjct: 3199 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKL----------GRSEERDKEELEDLKFS 3248

Query: 294  VAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQD----QSEGNSLQNQAL-Q 348
            + ++  +   L + L++  QLL+   + +E+      R++ D    + +G +L+ Q L +
Sbjct: 3249 LESQKQRNLQLNLLLEQQKQLLNESQQKIES-----QRMLYDAQLSEEQGRNLELQVLLE 3303

Query: 349  TFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVD 408
            + + R+ E  +TL RE+E + Q+QS      ++  +  ++L + +   +++  ++  R+ 
Sbjct: 3304 SEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL---QKQLEEKHSRIV 3360

Query: 409  ELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMEL 468
            EL  + + YKL+   ++Q++   +Q   + LQ++++        +  EG         ++
Sbjct: 3361 ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQE--------ANTEGQKKMHELQSKV 3412

Query: 469  EELRHEKEMQREEIQK--LMGQ-IHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQK 525
            E+L+ + E +R+++ K  L GQ +  +  E Q  E ++  + ES R   Q+L++      
Sbjct: 3413 EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSL 3472

Query: 526  AS----------KQELET--------------------ELERLKQEFHYIEEDLYRTKNT 555
             S          K E ET                    ELE ++Q+   +   L      
Sbjct: 3473 TSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQK 3532

Query: 556  LQSRIK-----DRD-----EEIQKLRNQLTNKTLSNSSQSEL---ENRLHQLTETLIQKQ 602
               R++     D D     E I ++  QL   T     +  L         LTE L+++ 
Sbjct: 3533 ASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQN 3592

Query: 603  TML----ESLSTEKNSLVFQLERLEQQM---NSASGSSSNGSSINMSGIDNGE 648
              L      L+ EKN L   + +LE+Q+           N S  +++G  N E
Sbjct: 3593 AELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIE 3645



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 109/508 (21%), Positives = 213/508 (41%), Gaps = 79/508 (15%)

Query: 182  EAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSL 241
            + +S S SS      S  E    +    +HT   ++   S+  S++   +  + ++V   
Sbjct: 1758 DRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE 1817

Query: 242  NQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQL 301
              E++  L RS     E++     +            ++  L+A V+ L EA++   SQL
Sbjct: 1818 GTELSQRLVRSGFAGTEIDPENEELML---------NISSRLQAAVEKLLEAISETSSQL 1868

Query: 302  AVLKV-----------RLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTF 350
               KV           + QEA + L  + E  E L  E+SR  +  +   S     +  +
Sbjct: 1869 EHAKVTQTELMRESFRQKQEATESLKCQEELRERLH-EESRAREQLAVELSKAEGVIDGY 1927

Query: 351  QERLHEADATLKREQESYKQMQSEFAA---RLNKVEMERQNLAEAITLAERKYSDEKKRV 407
             +     +  ++ + +   +++ E      RL ++E E+Q + E   L  R+    K   
Sbjct: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987

Query: 408  DELQQQV-----KLY--KLNLESSKQELIDYKQKATRILQ-SKEKLIN---SLKEGSGFE 456
              ++QQ+     KL   KL ++   +++ D  QK  + L+   E+ ++    L++    E
Sbjct: 1988 GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTE 2047

Query: 457  GLD---SSTASSMELEELR-----------HEKEMQREEIQKLMGQIHQLRSELQDMEAQ 502
             +D    + A   +LE++R           HE+++ ++EIQKL  Q+ ++    Q +   
Sbjct: 2048 LMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL-KVVPRFQPISEH 2106

Query: 503  QVNEAESAREQLQDLHDQIAGQKASKQELE-------TELERLKQEFHYIEEDLYRTKNT 555
            Q  E E     L++  D+ +    SK++L+        E+E+L+     +E+ L  + +T
Sbjct: 2107 QTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADT 2166

Query: 556  LQSRIKDR--------------DEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQK 601
             Q +++DR              + ++Q  R+ +  K       + LE +L Q  E L  K
Sbjct: 2167 FQ-KVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK---EKEITNLEEQLEQFREELENK 2222

Query: 602  ----QTMLESLSTEKNSLVFQLERLEQQ 625
                Q +   L  +K     +L+ LEQ+
Sbjct: 2223 NEEVQQLHMQLEIQKKESTTRLQELEQE 2250



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 85/431 (19%), Positives = 180/431 (41%), Gaps = 49/431 (11%)

Query: 265 RVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEA 324
           R E++  D S S++  +     ++ +   +A K  ++  L   L+E    ++  TE L+ 
Sbjct: 135 REEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE--MRVTYGTEGLQQ 192

Query: 325 LQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEM 384
           LQ  ++ I Q     + +  Q     Q+   E D T++   E  +Q Q        K+++
Sbjct: 193 LQEFEAAIKQR----DGIITQLTANLQQARREKDETMREFLELTEQSQ--------KLQI 240

Query: 385 ERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEK 444
           + Q L  + TL    +S     + + +QQ+  ++  LE     L DY++K          
Sbjct: 241 QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF 300

Query: 445 LINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQV 504
           L   +K                E+E+ +  +   +EEIQ+    I +L +++ + E + +
Sbjct: 301 LQEKIK--------------VYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTL 346

Query: 505 ---NEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIK 561
              ++  +A + L +L +QI  +    + ++ EL   KQ+     E++ +   T++  ++
Sbjct: 347 ELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVE-ELQ 405

Query: 562 DRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQ-LE 620
            R+ +  +    +  + +   +Q +LE    +L E   Q+   +      K  L+ Q + 
Sbjct: 406 KRNHKDSQFETDIVQR-MEQETQRKLEQLRAELDEMYGQQIVQM------KQELIRQHMA 458

Query: 621 RLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSI 680
           ++E+      G   N      +   N +  +L NV +     E N+     K++   S  
Sbjct: 459 QMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAI----NELNI-----KLQDTNSQK 509

Query: 681 DQFSIRLGIFL 691
           ++    LG+ L
Sbjct: 510 EKLKEELGLIL 520



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 80/405 (19%), Positives = 175/405 (43%), Gaps = 44/405 (10%)

Query: 228  RLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQV 287
            + + + L +E+Q+L+ +M       K  QE    ++  +E +N    +S  +   ++ ++
Sbjct: 3084 KADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLE-YNIQQKQSQMLE--MQVEL 3140

Query: 288  DDLTEAVAAKDSQLAVLKVRLQEA-DQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQA 346
              + +       QL+  K+ + E   +L  T+ E    L+++   + + ++    ++++ 
Sbjct: 3141 SSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKT 3200

Query: 347  LQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKR 406
                 + +H  + TL  EQ+  +++Q  +A    K ++ R    +   L + K+S E ++
Sbjct: 3201 -----DEVHLLNDTLASEQKKSRELQ--WALEKEKAKLGRSEERDKEELEDLKFSLESQK 3253

Query: 407  VDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSM 466
               LQ       L LE  KQ L + +QK    ++S+  L ++         L      ++
Sbjct: 3254 QRNLQ-----LNLLLEQQKQLLNESQQK----IESQRMLYDAQ--------LSEEQGRNL 3296

Query: 467  ELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQ-QVNEAESAREQLQDLHDQIAGQK 525
            EL+ L   ++++  E+   + +  +L ++LQ  +   Q      + + L++L  Q+  + 
Sbjct: 3297 ELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKH 3356

Query: 526  ASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQS 585
            +   EL  E E+ K +          +  T Q   KDR    + L+ +    T       
Sbjct: 3357 SRIVELLNETEKYKLD----------SLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMH 3406

Query: 586  ELENRLHQLTETLIQKQTMLESLSTEKNSL-----VFQLERLEQQ 625
            EL++++  L   L +K+  +  L  E   L      FQ + LE++
Sbjct: 3407 ELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3451



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 121/627 (19%), Positives = 261/627 (41%), Gaps = 98/627 (15%)

Query: 92  VEASHPVENASVPRPSSHFVRRKKS--------EPDDELLFDFLNSSQKEPTGRVEIRKE 143
           ++AS  + N++    ++  ++ K+         E  D LL D+    +++ T ++   +E
Sbjct: 245 LQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDY-QKKKEDFTMQISFLQE 303

Query: 144 KGKTPVFQSSQTSSVSSVNPSVT----------TIKTIEENSFGSQTHEAASNSDSS-HE 192
           K K  V++  Q   V + N                K IEE     +  +  + +D    E
Sbjct: 304 KIK--VYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE 361

Query: 193 GQEESSKENVSSNAACPDHTPTPNDDGKS-HELSNLRLENQLLRNEVQSLNQEMASLLQR 251
            QE+  ++N        + T +   + +S  E+  L    + L+      +Q    ++QR
Sbjct: 362 LQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR 421

Query: 252 -SKETQEELNKARARVEKWNADH--SKSDRMTRGLRAQVDDLTEA--------------V 294
             +ETQ +L + RA +++            + R   AQ++++                 +
Sbjct: 422 MEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNI 481

Query: 295 AAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERL 354
              + Q+ ++ V + E +  L       E L+ E   I++++    +LQ Q L+   E L
Sbjct: 482 TVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKC---ALQRQ-LEDLVEEL 537

Query: 355 HEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAE-RKYSDEKKRVDELQQQ 413
             +   ++R +++  + +S+       +       AE ++ +E RK  + K   +    +
Sbjct: 538 SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYK 597

Query: 414 VKLYKLNLESS-------KQELIDYKQKATRILQSKEKLINSLKEGSGFE---------- 456
           +KL  L  E +       + +  + ++  T++L S E+ ++ LKE    E          
Sbjct: 598 IKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKD 657

Query: 457 -----------GLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVN 505
                      GL +    S ++E ++ EK+    +  +L+ +I    S+L+D++   VN
Sbjct: 658 NLGIHYKQQIDGLQNEM--SQKIETMQFEKDNLITKQNQLILEI----SKLKDLQQSLVN 711

Query: 506 -EAESAREQLQDLHDQI---AGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIK 561
            ++E    Q+ +L  +I     ++  K  LE E++ L+ +   +E+ +   +N LQ +  
Sbjct: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771

Query: 562 DRDEEIQKLRNQLTNKTLSNS-------SQSE----LENRLHQLTETLIQK--QTMLESL 608
             + E   L+++   KTL +        SQ E    L++   +  +++ +K  + ++E  
Sbjct: 772 QLEAENSILKDE--KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEEN 829

Query: 609 STEKNSLVFQLERLEQQMNSASGSSSN 635
              K   +   E +E+Q N+ S +  N
Sbjct: 830 EDLKQQCIQLNEEIEKQRNTFSFAEKN 856



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 93/481 (19%), Positives = 199/481 (41%), Gaps = 67/481 (13%)

Query: 220  KSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEK------WNADH 273
            K+ + S L L  + L+ ++Q  N+E+  L  R +E ++ L  +    +K      + A  
Sbjct: 2121 KTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVE 2180

Query: 274  SKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEAL-------Q 326
            +K +     L  Q+    +A+  K+ ++  L+ +L++  + L  + E ++ L       +
Sbjct: 2181 AKPEL---SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2237

Query: 327  SEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMER 386
             E +  +Q+  + N L    ++     + E+DA   ++Q     +  +FA  + + E+E 
Sbjct: 2238 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV---LFGKFAQIIQEKEVEI 2294

Query: 387  QNLAEAITLAER--KYSDEKKRVDELQQQVK-----------------------LYKLN- 420
              L E +T  ++  K + + K ++E  + ++                       + +LN 
Sbjct: 2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNE 2354

Query: 421  -LESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQR 479
             +E  +QEL +  QK +    S  +  +SLK       +    A   ++E    E    +
Sbjct: 2355 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVV-IAEKLALEQQVETANEEMTFMK 2413

Query: 480  EEIQKLMGQIHQLRSELQDM--EAQQVNEAESAREQLQDLH-DQIAGQKASKQELETE-- 534
              +++   +++QL  EL  +  E + V + +S  E   ++  D ++  K   + + TE  
Sbjct: 2414 NVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDA 2473

Query: 535  LERLKQE--FHYIEE-------DLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQS 585
            L+ L+ +  F   EE       +L      L+S +  +D E+ +   Q+  K +    Q 
Sbjct: 2474 LKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQI--KDMQEQGQF 2531

Query: 586  ELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGID 645
            E E     L + ++  Q ++E           QLE +++       + +  S    + I 
Sbjct: 2532 ETE----MLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQ 2587

Query: 646  N 646
            N
Sbjct: 2588 N 2588



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 94/451 (20%), Positives = 183/451 (40%), Gaps = 58/451 (12%)

Query: 218  DGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSD 277
            D +  E     LE Q+L    +   +EM+S L R +E   +L  +    +  +     S+
Sbjct: 3285 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ--SRPPLPSE 3342

Query: 278  RMTRGLRAQVDDLTEAVAAKDSQLAVLKV-RLQEADQLLSTRTEALEALQSEKSRIMQDQ 336
             + + L+ Q+++    +    ++    K+  LQ   Q+   R    + LQ+E+    + Q
Sbjct: 3343 DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQ 3402

Query: 337  SEGNSLQNQA------LQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMER---Q 387
             + + LQ++       L+  ++++++ D   +R Q   ++ Q +   R  K E  R   Q
Sbjct: 3403 KKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQ 3462

Query: 388  NLAEAITLA-----------------ERKYSDEKKRVDE------LQQQVKLYKLNLESS 424
            NL E  T +                 E K S+  K ++          ++++ +  L+  
Sbjct: 3463 NLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCV 3522

Query: 425  KQELIDYKQKATRILQSK--------------EKLINSLKEGSGFEGLDSSTAS-SMELE 469
              +L    QKA+  LQ +              +++I  L++ +G +G + S  S S    
Sbjct: 3523 ASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCG 3582

Query: 470  ELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQ 529
             L      Q  E   L G I QL  E  D+     N      EQ++      AG+  S +
Sbjct: 3583 SLTERLLRQNAE---LTGHISQLTEEKNDLR----NMVMKLEEQIRWYRQTGAGRDNSSR 3635

Query: 530  ELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELEN 589
                    ++      +E   R K TLQ  +K  + E+ KL+ +L N +L  +   + E+
Sbjct: 3636 FSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEH 3695

Query: 590  -RLHQLTETLIQKQTMLESLSTEKNSLVFQL 619
              L ++    ++ ++  ++L  +K  L+  L
Sbjct: 3696 VTLKRIYGKYLRAESFRKALIYQKKYLLLLL 3726



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 83/414 (20%), Positives = 157/414 (37%), Gaps = 91/414 (21%)

Query: 201  NVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELN 260
            N+    +   H+ +   D   H+L  +  E   L  +V++ N+EM  +    KET  ++N
Sbjct: 2365 NIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMN 2424

Query: 261  ----------KARARVEKWNA----------DHSKSDR------MTR------------- 281
                      + R  VEK  +          DH   D+      +T              
Sbjct: 2425 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2484

Query: 282  -----------GLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKS 330
                        L  ++  L   V+AKD +L     ++++  +     TE L+       
Sbjct: 2485 SFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQ 2544

Query: 331  RIMQD--------QSEGNSLQ--------NQALQTFQERLHEADATLKREQESYKQMQSE 374
            +I+++        Q +  ++Q        NQ + +  ER +  +    RE E    + S 
Sbjct: 2545 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDI-SA 2603

Query: 375  FAARLNKVEMERQNL-------AEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQE 427
               R++++E +   +        E + +AE+   +++K++ ELQ   KL + N +  +++
Sbjct: 2604 LTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQ---KLLEGNEKKQREK 2660

Query: 428  LIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMG 487
                  +   +L++  +L +S +E   F           ELE LR E    + E+     
Sbjct: 2661 EKKRSPQDVEVLKTTTELFHSNEESGFFN----------ELEALRAESVATKAELASYKE 2710

Query: 488  QIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQE 541
            +  +L+ EL   E        S ++ L  + D +A  K     LE E E   QE
Sbjct: 2711 KAEKLQEELLVKETNMT----SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2760



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 75/438 (17%), Positives = 179/438 (40%), Gaps = 39/438 (8%)

Query: 223  ELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQE---ELNKARARVEKWNADHSKSDRM 279
            + + L  EN +L++E ++L   +      S+E +    +  K++++   W  +       
Sbjct: 769  KFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEE 828

Query: 280  TRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEG 339
               L+ Q   L E +  + +  +  +   +   Q L      L  ++ +    ++D    
Sbjct: 829  NEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDD----LEDSKNK 884

Query: 340  NSLQNQA-LQTFQERLHEA---DATLKREQESYKQMQSEFAARLNK---VEMERQNLAEA 392
              L+ ++ L+   E LH       T+K +   + + ++  A  L     VE +   L E 
Sbjct: 885  QELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEK 944

Query: 393  ITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRI-LQSKE-KLINSLK 450
            + + +R+  +  +R+ +L +Q+K     +    +E+   KQ+  ++ L+ +E ++I +  
Sbjct: 945  LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 1004

Query: 451  EGSGFEGLDSSTASSME--LEELRHEKEMQREEIQKLMGQIHQLRSELQ-DMEAQQVNEA 507
                 +  D+  +S ++  +       E    ++ K  G+  ++  E +   E   V E 
Sbjct: 1005 RAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE 1064

Query: 508  ESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEI 567
                + + D    +  + + +    +E ++L++E + ++ +    +N L+ ++     E 
Sbjct: 1065 SKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE----QNDLRLQM-----EA 1115

Query: 568  QKLRNQLTNKTLSNSSQSELENR----LHQLTETLIQKQTMLESLSTEKNSLVFQLERLE 623
            Q++   L   T  +  +  +EN     L  L E LI  Q        EK   + ++ +LE
Sbjct: 1116 QRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQ-------EEKIKELQKIHQLE 1168

Query: 624  QQMNSASGSSSNGSSINM 641
             Q      +   G  +++
Sbjct: 1169 LQTMKTQETGDEGKPLHL 1186



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 95/523 (18%), Positives = 211/523 (40%), Gaps = 62/523 (11%)

Query: 217  DDGKSHELSNLR-LENQLLRNEVQSLNQEMASLLQRSKETQE----ELNKARARVEKWN- 270
            D     +LS+L+ LE   L  +VQ L   ++SL Q+ KET++    E++  + R++  + 
Sbjct: 1318 DVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1377

Query: 271  ----------------ADHSKSDRMTRGLRAQVDDLTE---AVAAKDSQLAVLKVRLQEA 311
                            +D  ++      ++  +D   E       K+    V  +  Q  
Sbjct: 1378 STVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQ 1437

Query: 312  DQLLSTRTEALEAL------QSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQ 365
            +QL     + + ++      Q+E SRI   +    S +       QE+ +  +  L ++Q
Sbjct: 1438 EQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQ 1497

Query: 366  ---ESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVD-------ELQQQVK 415
               ++++ +  +F      +  E     + I L+     D  +  D       E+  + K
Sbjct: 1498 IGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDK 1557

Query: 416  LYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEK 475
             + +  +S   E+      A+R L   E+ +  +++    +  +   A+ +  +    + 
Sbjct: 1558 TFIVR-QSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQM 1616

Query: 476  EMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQ--LQDLHDQIAGQKASKQELET 533
            E QRE+ ++L  +I +L  +L    +       S RE+  L++L        A +++L  
Sbjct: 1617 ERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCC 1676

Query: 534  ELERLKQEFHYIEEDLYRTKNTLQSRIKD---RDEEIQKLRNQLTNKTLSNS--SQSELE 588
            EL     +         +  N  Q  +++   +++E+ +    +  + LSN   +  +  
Sbjct: 1677 ELRNSSTQ--------TQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKAN 1728

Query: 589  NRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGE 648
            NRL ++   +++    +E   T    ++  L+R  +  +SAS    + +  ++    + E
Sbjct: 1729 NRLLKILLEVVKTTAAVE--ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEE 1786

Query: 649  GTRLRNVPV---LFNDTETNLAGMYGKVRKAASSIDQFSIRLG 688
             TR+ +  +     +D   N   M+ KV +  + + Q  +R G
Sbjct: 1787 HTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSG 1829



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 57/252 (22%), Positives = 112/252 (44%), Gaps = 34/252 (13%)

Query: 391  EAITLAERKYSDEK----KRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLI 446
            + ++L E  YSD +    ++V E   + +   +N  SS ++LI   Q     LQ + ++ 
Sbjct: 2956 QVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQ-----LQREAEVY 3010

Query: 447  NSLKEGSGFEGLDSSTASSME---LEELRHEKEMQREEIQKL-----MGQIHQLRSELQD 498
            +S +    F         +++   LEE        R E+  L     +G ++ L   +Q+
Sbjct: 3011 DSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQE 3070

Query: 499  --------MEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLY 550
                    ME  Q  +  S   ++Q LH Q+ G+K + +  E E E+  QE   +E ++ 
Sbjct: 3071 QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKR-EQESEKPSQEL--LEYNIQ 3127

Query: 551  RTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRL-HQLTETLIQKQTMLESLS 609
            +     QS++ +   E+  ++++ T      SS+  +   L  +L +T ++ +T L++  
Sbjct: 3128 QK----QSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQH 3183

Query: 610  TEKNSL-VFQLE 620
                 L  F+LE
Sbjct: 3184 KHLKELEAFRLE 3195



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 91/467 (19%), Positives = 186/467 (39%), Gaps = 55/467 (11%)

Query: 182  EAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEV--Q 239
            E   N+ S  E   E + + +    AC        +D K+ +    + + + L  E+  Q
Sbjct: 844  EKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQ 903

Query: 240  SLN----QEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRG----LRAQVDDLT 291
             +N    +  +S+    K    E  +    VEK   +  +   +T+     L  ++ DL+
Sbjct: 904  RINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLS 963

Query: 292  EAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQ 351
            E +  K  +++ L    +E   L   + +   +L+  +  I+ + +   ++Q+   Q   
Sbjct: 964  EQLKQKHGEISFLN---EEVKSLKQEKEQV--SLRCRELEIIINHNRAENVQSCDTQVSS 1018

Query: 352  ERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQ 411
                    T +  + S  ++   F    +K+ +E +   E +T+ E     E+  +D L 
Sbjct: 1019 LLDGVVTMTSRGAEGSVSKVNKSFGEE-SKIMVEDKVSFENMTVGEES-KQEQLILDHLP 1076

Query: 412  QQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGF-EGLDSSTASSMELEE 470
               K  + +L +++    D  QK   +L+S++  +    E       L  ST      E 
Sbjct: 1077 SVTK--ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREY 1134

Query: 471  LRHEKEM------------QREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLH 518
            + +EK+             Q E+I++L  +IHQL  ELQ M+ Q+  +      + + LH
Sbjct: 1135 MENEKDKALCSLKEELIFAQEEKIKELQ-KIHQL--ELQTMKTQETGD------EGKPLH 1185

Query: 519  DQIAG-QKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNK 577
              I   QKA  +E    L+ L      +  + Y      +   +D++          +  
Sbjct: 1186 LLIGKLQKAVSEECSYFLQTLCS----VLGEYYTPALKCEVNAEDKEN---------SGD 1232

Query: 578  TLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQ 624
             +S +   EL++  +++ +      T+L  ++ E N L+    RL +
Sbjct: 1233 YISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSK 1279


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 120/533 (22%), Positives = 227/533 (42%), Gaps = 92/533 (17%)

Query: 182  EAASNSDSSHEGQEESSKENV------SSNAACPDHTPTPNDDGKSH--ELSNLRLENQL 233
            E +S  D + E QE+ S E +      S  A       T       H  EL   RLE + 
Sbjct: 3131 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3190

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEA 293
              +EV  LN  +AS  ++S+E Q  L K +A++           R     + +++DL  +
Sbjct: 3191 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKL----------GRSEERDKEELEDLKFS 3240

Query: 294  VAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQD----QSEGNSLQNQAL-Q 348
            + ++  +   L + L++  QLL+   + +E+      R++ D    + +G +L+ Q L +
Sbjct: 3241 LESQKQRNLQLNLLLEQQKQLLNESQQKIES-----QRMLYDAQLSEEQGRNLELQVLLE 3295

Query: 349  TFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVD 408
            + + R+ E  +TL RE+E + Q+QS      ++  +  ++L + +   +++  ++  R+ 
Sbjct: 3296 SEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL---QKQLEEKHSRIV 3352

Query: 409  ELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMEL 468
            EL  + + YKL+   ++Q++   +Q   + LQ++++        +  EG         ++
Sbjct: 3353 ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQE--------ANTEGQKKMHELQSKV 3404

Query: 469  EELRHEKEMQREEIQK--LMGQ-IHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQK 525
            E+L+ + E +R+++ K  L GQ +  +  E Q  E ++  + ES R   Q+L++      
Sbjct: 3405 EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSL 3464

Query: 526  AS----------KQELET--------------------ELERLKQEFHYIEEDLYRTKNT 555
             S          K E ET                    ELE ++Q+   +   L      
Sbjct: 3465 TSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQK 3524

Query: 556  LQSRIK-----DRD-----EEIQKLRNQLTNKTLSNSSQSEL---ENRLHQLTETLIQKQ 602
               R++     D D     E I ++  QL   T     +  L         LTE L+++ 
Sbjct: 3525 ASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQN 3584

Query: 603  TML----ESLSTEKNSLVFQLERLEQQM---NSASGSSSNGSSINMSGIDNGE 648
              L      L+ EKN L   + +LE+Q+           N S  +++G  N E
Sbjct: 3585 AELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIE 3637



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 106/490 (21%), Positives = 205/490 (41%), Gaps = 53/490 (10%)

Query: 220  KSHELSNLRLENQLLRNEVQSLNQEM-ASLLQRSKET---QEELNKARARVEKWNADHSK 275
            K+ EL +LR +NQ L  +++ + + +    + R  E    Q+E+ K   +++        
Sbjct: 2044 KNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPI 2103

Query: 276  SDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALE--ALQSEKSRIM 333
            S+  TR +    + L E    K S+L + K +LQ   Q  +   E LE    + E++ ++
Sbjct: 2104 SEHQTREVEQLANHLKEKTD-KCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162

Query: 334  QDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAI 393
            +D+    +++ +   + + +L      + R+++    ++ +      ++E + + + +  
Sbjct: 2163 EDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLH 2222

Query: 394  TLAERKYSDEKKRVDELQQQVKLYKLNLES-----------SKQELIDYKQKATRILQSK 442
               E +  +   R+ EL+Q+ KL+K ++E            S Q+      K  +I+Q K
Sbjct: 2223 MQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEK 2282

Query: 443  EKLINSLKEGSGFEGLDSSTASSMELEELRHEK--EMQREEIQKLMGQIHQLRSELQDME 500
            E  I+ L E          T    +L+     K  E + E I+ L  QI  L S+ + ++
Sbjct: 2283 EVEIDQLNE--------QVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVK 2334

Query: 501  AQQVNEAESAREQLQDLHDQIA--GQKAS--KQELETELERLKQEFHYI------EEDLY 550
              +  E E   E ++ L  ++A  GQK S     L  E + LK +   +       E   
Sbjct: 2335 RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQV 2394

Query: 551  RTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLST 610
             T N   + +K+  +E     NQLT +  S   + E   ++  + E  +     ++ LS 
Sbjct: 2395 ETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSV--NVAIDHLSK 2452

Query: 611  EKNSLVF-----QLERLEQQMNSAS-GSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTET 664
            +K  L        L+ LE Q    S   +  GS IN+        TRL  +    +  + 
Sbjct: 2453 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLE-------TRLLQLESTVSAKDL 2505

Query: 665  NLAGMYGKVR 674
             L   Y +++
Sbjct: 2506 ELTQCYKQIK 2515



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 106/502 (21%), Positives = 210/502 (41%), Gaps = 75/502 (14%)

Query: 182  EAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSL 241
            + +S S SS      S  E    +    +HT   ++   S+  S++   +  + ++V   
Sbjct: 1758 DRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE 1817

Query: 242  NQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQL 301
              E++  L RS     E++     +            ++  L+A V+ L EA++   SQL
Sbjct: 1818 GTELSQRLVRSGFAGTEIDPENEELML---------NISSRLQAAVEKLLEAISETSSQL 1868

Query: 302  AVLKV-----------RLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTF 350
               KV           + QEA + L  + E  E L  E+SR  +  +   S     +  +
Sbjct: 1869 EHAKVTQTELMRESFRQKQEATESLKCQEELRERLH-EESRAREQLAVELSKAEGVIDGY 1927

Query: 351  QERLHEADATLKREQESYKQMQSEFAA---RLNKVEMERQNLAEAITLAERKYSDEKKRV 407
             +     +  ++ + +   +++ E      RL ++E E+Q + E   L  R+    K   
Sbjct: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987

Query: 408  DELQQQV-----KLY--KLNLESSKQELIDYKQKATRILQ-SKEKLIN---SLKEGSGFE 456
              ++QQ+     KL   KL ++   +++ D  QK  + L+   E+ ++    L++    E
Sbjct: 1988 GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTE 2047

Query: 457  GLD---SSTASSMELEELR-----------HEKEMQREEIQKLMGQIHQLRSELQDMEAQ 502
             +D    + A   +LE++R           HE+++ ++EIQKL  Q+ ++    Q +   
Sbjct: 2048 LMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL-KVVPRFQPISEH 2106

Query: 503  QVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQS-RIK 561
            Q  E E     L++  D+ +    SK++L+ +++   +E   +E   +R +   Q+  ++
Sbjct: 2107 QTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLE---FRVRELEQALLVE 2163

Query: 562  DR--------------DEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQK----QT 603
            DR              + ++Q  R+ +  K       + LE +L Q  E L  K    Q 
Sbjct: 2164 DRKHFGAVEAKPELSLEVQLQAERDAIDRK---EKEITNLEEQLEQFREELENKNEEVQQ 2220

Query: 604  MLESLSTEKNSLVFQLERLEQQ 625
            +   L  +K     +L+ LEQ+
Sbjct: 2221 LHMQLEIQKKESTTRLQELEQE 2242



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 85/431 (19%), Positives = 180/431 (41%), Gaps = 49/431 (11%)

Query: 265 RVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEA 324
           R E++  D S S++  +     ++ +   +A K  ++  L   L+E    ++  TE L+ 
Sbjct: 135 REEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE--MRVTYGTEGLQQ 192

Query: 325 LQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEM 384
           LQ  ++ I Q     + +  Q     Q+   E D T++   E  +Q Q        K+++
Sbjct: 193 LQEFEAAIKQR----DGIITQLTANLQQARREKDETMREFLELTEQSQ--------KLQI 240

Query: 385 ERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEK 444
           + Q L  + TL    +S     + + +QQ+  ++  LE     L DY++K          
Sbjct: 241 QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF 300

Query: 445 LINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQV 504
           L   +K                E+E+ +  +   +EEIQ+    I +L +++ + E + +
Sbjct: 301 LQEKIK--------------VYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTL 346

Query: 505 ---NEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIK 561
              ++  +A + L +L +QI  +    + ++ EL   KQ+     E++ +   T++  ++
Sbjct: 347 ELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVE-ELQ 405

Query: 562 DRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQ-LE 620
            R+ +  +    +  + +   +Q +LE    +L E   Q+   +      K  L+ Q + 
Sbjct: 406 KRNHKDSQFETDIVQR-MEQETQRKLEQLRAELDEMYGQQIVQM------KQELIRQHMA 458

Query: 621 RLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSI 680
           ++E+      G   N      +   N +  +L NV +     E N+     K++   S  
Sbjct: 459 QMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAI----NELNI-----KLQDTNSQK 509

Query: 681 DQFSIRLGIFL 691
           ++    LG+ L
Sbjct: 510 EKLKEELGLIL 520



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 97/465 (20%), Positives = 198/465 (42%), Gaps = 73/465 (15%)

Query: 218  DGKSHELSNLRLENQLLRNEVQSLNQEMASL-----------LQRSKETQEELNKARARV 266
            D K  E++NL  + +  R E+++ N+E+  L             R +E ++E    +  +
Sbjct: 2191 DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDM 2250

Query: 267  EKWNADHSKSDRMT---------------RGLRAQVDDLTEAVAAKDSQLAVL---KVRL 308
            EK      +SD M+               +    ++D L E V     QL +    KV +
Sbjct: 2251 EKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKV-I 2309

Query: 309  QEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADA-------TL 361
            +E ++L+      +E L S++  + +++ E     N+ ++  Q+ L            +L
Sbjct: 2310 EEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSL 2369

Query: 362  KREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNL 421
              E +S K       A    +E + +   E +T  +    +   ++++L Q++   K   
Sbjct: 2370 SEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER 2429

Query: 422  ES----------SKQELIDY--KQKATRILQSKEKLINSLKEGSGFEGLDSSTASS---M 466
            ES          S    ID+  K K    +   E  + SL+  + F+  + +   S   +
Sbjct: 2430 ESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINL 2489

Query: 467  ELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDL----HDQIA 522
            E   L+ E  +  +++     ++ Q   +++DM+ Q   E E  ++++ +L     +++A
Sbjct: 2490 ETRLLQLESTVSAKDL-----ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVA 2544

Query: 523  GQKASKQELETELERLK--QEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLS 580
                S+ +LE   E  K  Q+   I  +  RT   +Q+  + R++E+    + LT +   
Sbjct: 2545 AALVSQIQLEAVQEYAKFCQDNQTISSEPERT--NIQNLNQLREDELGSDISALTLRI-- 2600

Query: 581  NSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQ 625
                SELE+++ ++  +LI ++  +E    EKN L  + + LE Q
Sbjct: 2601 ----SELESQVVEMHTSLILEKEQVE--IAEKNVLEKEKKLLELQ 2639



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 80/405 (19%), Positives = 175/405 (43%), Gaps = 44/405 (10%)

Query: 228  RLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQV 287
            + + + L +E+Q+L+ +M       K  QE    ++  +E +N    +S  +   ++ ++
Sbjct: 3076 KADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLE-YNIQQKQSQMLE--MQVEL 3132

Query: 288  DDLTEAVAAKDSQLAVLKVRLQEA-DQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQA 346
              + +       QL+  K+ + E   +L  T+ E    L+++   + + ++    ++++ 
Sbjct: 3133 SSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKT 3192

Query: 347  LQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKR 406
                 + +H  + TL  EQ+  +++Q  +A    K ++ R    +   L + K+S E ++
Sbjct: 3193 -----DEVHLLNDTLASEQKKSRELQ--WALEKEKAKLGRSEERDKEELEDLKFSLESQK 3245

Query: 407  VDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSM 466
               LQ       L LE  KQ L + +QK    ++S+  L ++         L      ++
Sbjct: 3246 QRNLQ-----LNLLLEQQKQLLNESQQK----IESQRMLYDAQ--------LSEEQGRNL 3288

Query: 467  ELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQ-QVNEAESAREQLQDLHDQIAGQK 525
            EL+ L   ++++  E+   + +  +L ++LQ  +   Q      + + L++L  Q+  + 
Sbjct: 3289 ELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKH 3348

Query: 526  ASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQS 585
            +   EL  E E+ K +          +  T Q   KDR    + L+ +    T       
Sbjct: 3349 SRIVELLNETEKYKLD----------SLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMH 3398

Query: 586  ELENRLHQLTETLIQKQTMLESLSTEKNSL-----VFQLERLEQQ 625
            EL++++  L   L +K+  +  L  E   L      FQ + LE++
Sbjct: 3399 ELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3443



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 121/627 (19%), Positives = 261/627 (41%), Gaps = 98/627 (15%)

Query: 92  VEASHPVENASVPRPSSHFVRRKKS--------EPDDELLFDFLNSSQKEPTGRVEIRKE 143
           ++AS  + N++    ++  ++ K+         E  D LL D+    +++ T ++   +E
Sbjct: 245 LQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDY-QKKKEDFTMQISFLQE 303

Query: 144 KGKTPVFQSSQTSSVSSVNPSVT----------TIKTIEENSFGSQTHEAASNSDSS-HE 192
           K K  V++  Q   V + N                K IEE     +  +  + +D    E
Sbjct: 304 KIK--VYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE 361

Query: 193 GQEESSKENVSSNAACPDHTPTPNDDGKS-HELSNLRLENQLLRNEVQSLNQEMASLLQR 251
            QE+  ++N        + T +   + +S  E+  L    + L+      +Q    ++QR
Sbjct: 362 LQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR 421

Query: 252 -SKETQEELNKARARVEKWNADH--SKSDRMTRGLRAQVDDLTEA--------------V 294
             +ETQ +L + RA +++            + R   AQ++++                 +
Sbjct: 422 MEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNI 481

Query: 295 AAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERL 354
              + Q+ ++ V + E +  L       E L+ E   I++++    +LQ Q L+   E L
Sbjct: 482 TVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKC---ALQRQ-LEDLVEEL 537

Query: 355 HEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAE-RKYSDEKKRVDELQQQ 413
             +   ++R +++  + +S+       +       AE ++ +E RK  + K   +    +
Sbjct: 538 SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYK 597

Query: 414 VKLYKLNLESS-------KQELIDYKQKATRILQSKEKLINSLKEGSGFE---------- 456
           +KL  L  E +       + +  + ++  T++L S E+ ++ LKE    E          
Sbjct: 598 IKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKD 657

Query: 457 -----------GLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVN 505
                      GL +    S ++E ++ EK+    +  +L+ +I    S+L+D++   VN
Sbjct: 658 NLGIHYKQQIDGLQNEM--SQKIETMQFEKDNLITKQNQLILEI----SKLKDLQQSLVN 711

Query: 506 -EAESAREQLQDLHDQI---AGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIK 561
            ++E    Q+ +L  +I     ++  K  LE E++ L+ +   +E+ +   +N LQ +  
Sbjct: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771

Query: 562 DRDEEIQKLRNQLTNKTLSNS-------SQSE----LENRLHQLTETLIQK--QTMLESL 608
             + E   L+++   KTL +        SQ E    L++   +  +++ +K  + ++E  
Sbjct: 772 QLEAENSILKDE--KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEEN 829

Query: 609 STEKNSLVFQLERLEQQMNSASGSSSN 635
              K   +   E +E+Q N+ S +  N
Sbjct: 830 EDLKQQCIQLNEEIEKQRNTFSFAEKN 856



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 94/451 (20%), Positives = 183/451 (40%), Gaps = 58/451 (12%)

Query: 218  DGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSD 277
            D +  E     LE Q+L    +   +EM+S L R +E   +L  +    +  +     S+
Sbjct: 3277 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ--SRPPLPSE 3334

Query: 278  RMTRGLRAQVDDLTEAVAAKDSQLAVLKV-RLQEADQLLSTRTEALEALQSEKSRIMQDQ 336
             + + L+ Q+++    +    ++    K+  LQ   Q+   R    + LQ+E+    + Q
Sbjct: 3335 DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQ 3394

Query: 337  SEGNSLQNQA------LQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMER---Q 387
             + + LQ++       L+  ++++++ D   +R Q   ++ Q +   R  K E  R   Q
Sbjct: 3395 KKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQ 3454

Query: 388  NLAEAITLA-----------------ERKYSDEKKRVDE------LQQQVKLYKLNLESS 424
            NL E  T +                 E K S+  K ++          ++++ +  L+  
Sbjct: 3455 NLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCV 3514

Query: 425  KQELIDYKQKATRILQSK--------------EKLINSLKEGSGFEGLDSSTAS-SMELE 469
              +L    QKA+  LQ +              +++I  L++ +G +G + S  S S    
Sbjct: 3515 ASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCG 3574

Query: 470  ELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQ 529
             L      Q  E   L G I QL  E  D+     N      EQ++      AG+  S +
Sbjct: 3575 SLTERLLRQNAE---LTGHISQLTEEKNDLR----NMVMKLEEQIRWYRQTGAGRDNSSR 3627

Query: 530  ELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELEN 589
                    ++      +E   R K TLQ  +K  + E+ KL+ +L N +L  +   + E+
Sbjct: 3628 FSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEH 3687

Query: 590  -RLHQLTETLIQKQTMLESLSTEKNSLVFQL 619
              L ++    ++ ++  ++L  +K  L+  L
Sbjct: 3688 VTLKRIYGKYLRAESFRKALIYQKKYLLLLL 3718



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 83/414 (20%), Positives = 157/414 (37%), Gaps = 91/414 (21%)

Query: 201  NVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELN 260
            N+    +   H+ +   D   H+L  +  E   L  +V++ N+EM  +    KET  ++N
Sbjct: 2357 NIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMN 2416

Query: 261  ----------KARARVEKWNA----------DHSKSDR------MTR------------- 281
                      + R  VEK  +          DH   D+      +T              
Sbjct: 2417 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2476

Query: 282  -----------GLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKS 330
                        L  ++  L   V+AKD +L     ++++  +     TE L+       
Sbjct: 2477 SFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQ 2536

Query: 331  RIMQD--------QSEGNSLQ--------NQALQTFQERLHEADATLKREQESYKQMQSE 374
            +I+++        Q +  ++Q        NQ + +  ER +  +    RE E    + S 
Sbjct: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDI-SA 2595

Query: 375  FAARLNKVEMERQNL-------AEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQE 427
               R++++E +   +        E + +AE+   +++K++ ELQ   KL + N +  +++
Sbjct: 2596 LTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQ---KLLEGNEKKQREK 2652

Query: 428  LIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMG 487
                  +   +L++  +L +S +E   F           ELE LR E    + E+     
Sbjct: 2653 EKKRSPQDVEVLKTTTELFHSNEESGFFN----------ELEALRAESVATKAELASYKE 2702

Query: 488  QIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQE 541
            +  +L+ EL   E        S ++ L  + D +A  K     LE E E   QE
Sbjct: 2703 KAEKLQEELLVKETNMT----SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2752



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 75/438 (17%), Positives = 179/438 (40%), Gaps = 39/438 (8%)

Query: 223  ELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQE---ELNKARARVEKWNADHSKSDRM 279
            + + L  EN +L++E ++L   +      S+E +    +  K++++   W  +       
Sbjct: 769  KFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEE 828

Query: 280  TRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEG 339
               L+ Q   L E +  + +  +  +   +   Q L      L  ++ +    ++D    
Sbjct: 829  NEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDD----LEDSKNK 884

Query: 340  NSLQNQA-LQTFQERLHEA---DATLKREQESYKQMQSEFAARLNK---VEMERQNLAEA 392
              L+ ++ L+   E LH       T+K +   + + ++  A  L     VE +   L E 
Sbjct: 885  QELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEK 944

Query: 393  ITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRI-LQSKE-KLINSLK 450
            + + +R+  +  +R+ +L +Q+K     +    +E+   KQ+  ++ L+ +E ++I +  
Sbjct: 945  LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 1004

Query: 451  EGSGFEGLDSSTASSME--LEELRHEKEMQREEIQKLMGQIHQLRSELQ-DMEAQQVNEA 507
                 +  D+  +S ++  +       E    ++ K  G+  ++  E +   E   V E 
Sbjct: 1005 RAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE 1064

Query: 508  ESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEI 567
                + + D    +  + + +    +E ++L++E + ++ +    +N L+ ++     E 
Sbjct: 1065 SKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE----QNDLRLQM-----EA 1115

Query: 568  QKLRNQLTNKTLSNSSQSELENR----LHQLTETLIQKQTMLESLSTEKNSLVFQLERLE 623
            Q++   L   T  +  +  +EN     L  L E LI  Q        EK   + ++ +LE
Sbjct: 1116 QRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQ-------EEKIKELQKIHQLE 1168

Query: 624  QQMNSASGSSSNGSSINM 641
             Q      +   G  +++
Sbjct: 1169 LQTMKTQETGDEGKPLHL 1186



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 95/523 (18%), Positives = 211/523 (40%), Gaps = 62/523 (11%)

Query: 217  DDGKSHELSNLR-LENQLLRNEVQSLNQEMASLLQRSKETQE----ELNKARARVEKWN- 270
            D     +LS+L+ LE   L  +VQ L   ++SL Q+ KET++    E++  + R++  + 
Sbjct: 1318 DVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1377

Query: 271  ----------------ADHSKSDRMTRGLRAQVDDLTE---AVAAKDSQLAVLKVRLQEA 311
                            +D  ++      ++  +D   E       K+    V  +  Q  
Sbjct: 1378 STVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQ 1437

Query: 312  DQLLSTRTEALEAL------QSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQ 365
            +QL     + + ++      Q+E SRI   +    S +       QE+ +  +  L ++Q
Sbjct: 1438 EQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQ 1497

Query: 366  ---ESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVD-------ELQQQVK 415
               ++++ +  +F      +  E     + I L+     D  +  D       E+  + K
Sbjct: 1498 IGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDK 1557

Query: 416  LYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEK 475
             + +  +S   E+      A+R L   E+ +  +++    +  +   A+ +  +    + 
Sbjct: 1558 TFIVR-QSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQM 1616

Query: 476  EMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQ--LQDLHDQIAGQKASKQELET 533
            E QRE+ ++L  +I +L  +L    +       S RE+  L++L        A +++L  
Sbjct: 1617 ERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCC 1676

Query: 534  ELERLKQEFHYIEEDLYRTKNTLQSRIKD---RDEEIQKLRNQLTNKTLSNS--SQSELE 588
            EL     +         +  N  Q  +++   +++E+ +    +  + LSN   +  +  
Sbjct: 1677 ELRNSSTQ--------TQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKAN 1728

Query: 589  NRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGE 648
            NRL ++   +++    +E   T    ++  L+R  +  +SAS    + +  ++    + E
Sbjct: 1729 NRLLKILLEVVKTTAAVE--ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEE 1786

Query: 649  GTRLRNVPV---LFNDTETNLAGMYGKVRKAASSIDQFSIRLG 688
             TR+ +  +     +D   N   M+ KV +  + + Q  +R G
Sbjct: 1787 HTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSG 1829



 Score = 37.4 bits (85), Expect = 0.050
 Identities = 95/446 (21%), Positives = 172/446 (38%), Gaps = 65/446 (14%)

Query: 224  LSNLRLENQLLRNEVQ--SLNQEMASLLQRSKETQEELNKARAR-VEKWNADHSKSDRMT 280
            +S++    QL+ NE Q   + QE+    Q  ++  E L +A  R +E+   D  +     
Sbjct: 1571 VSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEI 1630

Query: 281  RGLRAQVDDLTEAVAAKDSQLAVLKVR--LQEADQLLSTRTEALEALQSEKSRIMQDQSE 338
            + L  Q   L +  +  +  L   + R  L+E + L        E L  E          
Sbjct: 1631 KRLNRQ---LAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQN 1687

Query: 339  GNSLQNQAL-QTFQERLHEADATLKREQESYKQMQSEFAA------RLNKVEMERQNLAE 391
            GN  Q +   QTF+E+    +   K E    + + +E  A      RL K+ +E      
Sbjct: 1688 GNENQGEVEEQTFKEK----ELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTA 1743

Query: 392  AIT---------LAERKYSDEKKRV----DELQQQVK--LYKLNLESSKQELIDYKQKA- 435
            A+          + +R    +         E +  VK  +++ +   + + +  Y     
Sbjct: 1744 AVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDM 1803

Query: 436  --------TRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELR-HEKEMQREEIQKLM 486
                    +++ +   +L   L   SGF G    T    E EEL  +     +  ++KL+
Sbjct: 1804 PRNDINMWSKVTEEGTELSQRLVR-SGFAG----TEIDPENEELMLNISSRLQAAVEKLL 1858

Query: 487  GQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETEL---ERLKQEFH 543
              I +  S+L+  +  Q      +  Q Q+  + +  Q+  ++ L  E    E+L  E  
Sbjct: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELS 1918

Query: 544  YIEE--DLYRTKNTLQSR-IKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQ 600
              E   D Y  + TL  R I+++ + I +L  +L   +          NRL +L     Q
Sbjct: 1919 KAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS----------NRLQELEAEQQQ 1968

Query: 601  KQTMLESLSTEKNSLVFQLERLEQQM 626
             Q   E LS +K ++  +   +EQQ+
Sbjct: 1969 IQEERELLSRQKEAMKAEAGPVEQQL 1994



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 57/252 (22%), Positives = 112/252 (44%), Gaps = 34/252 (13%)

Query: 391  EAITLAERKYSDEK----KRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLI 446
            + ++L E  YSD +    ++V E   + +   +N  SS ++LI   Q     LQ + ++ 
Sbjct: 2948 QVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQ-----LQREAEVY 3002

Query: 447  NSLKEGSGFEGLDSSTASSME---LEELRHEKEMQREEIQKL-----MGQIHQLRSELQD 498
            +S +    F         +++   LEE        R E+  L     +G ++ L   +Q+
Sbjct: 3003 DSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQE 3062

Query: 499  --------MEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLY 550
                    ME  Q  +  S   ++Q LH Q+ G+K + +  E E E+  QE   +E ++ 
Sbjct: 3063 QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKR-EQESEKPSQEL--LEYNIQ 3119

Query: 551  RTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRL-HQLTETLIQKQTMLESLS 609
            +     QS++ +   E+  ++++ T      SS+  +   L  +L +T ++ +T L++  
Sbjct: 3120 QK----QSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQH 3175

Query: 610  TEKNSL-VFQLE 620
                 L  F+LE
Sbjct: 3176 KHLKELEAFRLE 3187



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 91/467 (19%), Positives = 186/467 (39%), Gaps = 55/467 (11%)

Query: 182  EAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEV--Q 239
            E   N+ S  E   E + + +    AC        +D K+ +    + + + L  E+  Q
Sbjct: 844  EKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQ 903

Query: 240  SLN----QEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRG----LRAQVDDLT 291
             +N    +  +S+    K    E  +    VEK   +  +   +T+     L  ++ DL+
Sbjct: 904  RINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLS 963

Query: 292  EAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQ 351
            E +  K  +++ L    +E   L   + +   +L+  +  I+ + +   ++Q+   Q   
Sbjct: 964  EQLKQKHGEISFLN---EEVKSLKQEKEQV--SLRCRELEIIINHNRAENVQSCDTQVSS 1018

Query: 352  ERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQ 411
                    T +  + S  ++   F    +K+ +E +   E +T+ E     E+  +D L 
Sbjct: 1019 LLDGVVTMTSRGAEGSVSKVNKSFGEE-SKIMVEDKVSFENMTVGEES-KQEQLILDHLP 1076

Query: 412  QQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGF-EGLDSSTASSMELEE 470
               K  + +L +++    D  QK   +L+S++  +    E       L  ST      E 
Sbjct: 1077 SVTK--ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREY 1134

Query: 471  LRHEKEM------------QREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLH 518
            + +EK+             Q E+I++L  +IHQL  ELQ M+ Q+  +      + + LH
Sbjct: 1135 MENEKDKALCSLKEELIFAQEEKIKELQ-KIHQL--ELQTMKTQETGD------EGKPLH 1185

Query: 519  DQIAG-QKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNK 577
              I   QKA  +E    L+ L      +  + Y      +   +D++          +  
Sbjct: 1186 LLIGKLQKAVSEECSYFLQTLCS----VLGEYYTPALKCEVNAEDKEN---------SGD 1232

Query: 578  TLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQ 624
             +S +   EL++  +++ +      T+L  ++ E N L+    RL +
Sbjct: 1233 YISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSK 1279


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 85/430 (19%), Positives = 189/430 (43%), Gaps = 25/430 (5%)

Query: 224  LSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGL 283
            +S L ++    + ++Q     + +L +  K  Q+E+     + E+  A + K ++    L
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425

Query: 284  RAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQ 343
            + ++DDL   +  +   ++ L+ + ++ DQLL+           E+ R   +  E  +  
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485

Query: 344  NQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDE 403
                +  +E L EA   L+R  +  K    +  +  + V      L ++    E +  + 
Sbjct: 1486 LSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544

Query: 404  KKRVDELQQQVKL---YKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDS 460
            K +++EL+ +++     KL LE + Q L   K +  R LQ++++     +     +  + 
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQAL---KGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 461  STASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEA-----QQVNEAESAREQLQ 515
             T    ELE+ R ++ +     +KL G +  L  ELQ   A     + + +    + Q++
Sbjct: 1602 ET----ELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQLRKLQAQMK 1655

Query: 516  DLHDQIAGQKASKQEL-------ETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQ 568
            D   ++   +AS+ E+       E + + L+ +   ++EDL   +   +    +++E  +
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1715

Query: 569  KLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
            +L + L+ +      +  LE R+ QL E L ++Q  +E++S        Q E+L  ++ +
Sbjct: 1716 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775

Query: 629  ASGSSSNGSS 638
               ++    S
Sbjct: 1776 ERSTAQKNES 1785



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 89/426 (20%), Positives = 176/426 (41%), Gaps = 30/426 (7%)

Query: 225  SNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLR 284
            +NL    Q L  E   L  E+  L Q  +E + +  K  A+V++  +  S  +R    L 
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1279

Query: 285  AQVDDLTEAVAAKDSQL--------------AVLKVRLQEADQLLSTRTEALEALQSEKS 330
             +V  L   V +    L              A L  +LQ+  +LL   T       +  +
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK---LNVST 1336

Query: 331  RIMQDQSEGNSLQNQALQTFQ--ERLHEADATLKREQESYKQMQSEFAARLNKVEMERQN 388
            ++ Q + E NSLQ+Q  +  +  + L    +TL  +    K+   +FA+ +  +E  ++ 
Sbjct: 1337 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396

Query: 389  LAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINS 448
              + I    ++Y ++    D+L++     +  L+    +L + +Q  + + + + K    
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456

Query: 449  LKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAE 508
            L E        +      E E    EKE +   + + + +  + + EL+        E E
Sbjct: 1457 LAEEKNISSKYADERDRAEAEA--REKETKALSLARALEEALEAKEELERTNKMLKAEME 1514

Query: 509  SAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQ 568
                   D+   +   + SK+ LET++E +K +   +E++L  T++  + R+   +  +Q
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA-KLRL---EVNMQ 1570

Query: 569  KLRNQLTNKTLSNSSQSE-----LENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLE 623
             L+ Q      +   Q+E     L+ +LH+    L  ++      +  K  L   L+ LE
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1630

Query: 624  QQMNSA 629
             Q +SA
Sbjct: 1631 LQADSA 1636



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 108/476 (22%), Positives = 204/476 (42%), Gaps = 83/476 (17%)

Query: 225  SNLRLENQLLRNEVQSLNQEMAS-------LLQRSKETQEELNKARARVEKWNADHSKSD 277
            S L  E  LL+ ++Q+  +  A        L  + +E +E L++  AR+E+      +  
Sbjct: 883  SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942

Query: 278  RMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQS 337
               + +  Q+ DL E +  ++ + A  K++L++      T    ++ L+ E   +M DQ+
Sbjct: 943  AERKKMAQQMLDLEEQL--EEEEAARQKLQLEKV-----TAEAKIKKLEDE-ILVMDDQN 994

Query: 338  EGNSLQNQALQTFQERLHEADATLKREQESYKQ----------MQSEFAARLNKVEMERQ 387
               S + + L+   ER+ +    L  E+E  K           M SE   RL K E  RQ
Sbjct: 995  NKLSKERKLLE---ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051

Query: 388  NLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQEL----------IDYKQKATR 437
             L +     E   SD  +++ +LQ Q+   K+ L   ++EL          I  K  A +
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1111

Query: 438  ILQSKEKLINSLKE-------------------GSGFEG----LDSSTASSMELEELRHE 474
             ++  E  I+ L+E                   G   E     L+ +  S+   +ELR +
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1171

Query: 475  KEMQREEIQKLMG-QIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELET 533
            +E +   ++K +  +     +++Q+M  +     E   EQL+      A    +KQ LE 
Sbjct: 1172 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1231

Query: 534  E----------LERLKQEFHYIEEDLYRTKNTLQSRIKDRD-------EEIQKLRNQLTN 576
            E          L + KQE  + ++ L      LQS+  D +       +++ KL+N++ +
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1291

Query: 577  KT-LSNSSQS---ELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
             T + N ++    +L   +  L+  L   Q +L+  + +K ++  +L +LE++ NS
Sbjct: 1292 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1347



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 100/404 (24%), Positives = 177/404 (43%), Gaps = 45/404 (11%)

Query: 237  EVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAA 296
            +V    +EM +     ++T+E   KA   +++    HS+       L+ Q+   TE  A 
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 297  KDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHE 356
             +     L  + QE +++L    E    L+ E+ R  Q Q+E   +  Q L   +E+L E
Sbjct: 906  AEEMRVRLAAKKQELEEILH---EMEARLEEEEDRGQQLQAERKKMAQQMLD-LEEQLEE 961

Query: 357  ADATLKREQ-------ESYKQMQSEFAA---RLNKVEMERQNLAEAITLAERKYSDEKKR 406
             +A  ++ Q          K+++ E      + NK+  ER+ L E I+      ++E+++
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021

Query: 407  VDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSM 466
               L +     K   ES   EL    +K  +  Q  EKL   L EG   +  +       
Sbjct: 1022 AKNLTK----LKNKHESMISELEVRLKKEEKSRQELEKLKRKL-EGDASDFHEQIADLQA 1076

Query: 467  ELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESARE---QLQDLHDQIAG 523
            ++ EL+ +   + EE+Q  +       + L D  AQ+ N  +  RE    + DL + +  
Sbjct: 1077 QIAELKMQLAKKEEELQAAL-------ARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129

Query: 524  QKAS-------KQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTN 576
            ++A+       K++L  ELE LK E   +E+ L  T    + R K R++E+  L+  L  
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTE---LEDTLDSTATQQELRAK-REQEVTVLKKALDE 1185

Query: 577  KTLSNSSQSELENRLH-----QLTETLIQKQTMLESLSTEKNSL 615
            +T S+ +Q +   + H     +LTE L Q +    +L   K +L
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 84/440 (19%), Positives = 180/440 (40%), Gaps = 60/440 (13%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEA 293
            L+N+ +S+  E+   L++ +++++EL K + ++E    D S        L+AQ+ +L   
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLE---GDASDFHEQIADLQAQIAELKMQ 1084

Query: 294  VAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQA------- 346
            +A K+ +L     RL +     +   + +  L+   S + +D     + +N+A       
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 347  ---LQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDE 403
               L+  +  L +   +   +QE   + + E       ++ E ++    +    +K++  
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204

Query: 404  KKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTA 463
             + + E  +Q K  K NL+ +KQ L    +K    L  + +++   K+            
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTL----EKENADLAGELRVLGQAKQ------------ 1248

Query: 464  SSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESA------------- 510
               E+E  + + E Q +E+Q       + R+EL D   +  NE ES              
Sbjct: 1249 ---EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305

Query: 511  --------REQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDL---YRTKNTLQSR 559
                      QLQD  + +  +   K  + T+L +L++E + +++ L      K  L+  
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365

Query: 560  IKDRDEEI----QKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSL 615
            I   + ++    +KL++  +        +   +  +  LT+   +K    + L   KN L
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425

Query: 616  VFQLERLEQQMNSASGSSSN 635
              +L+ L   +++     SN
Sbjct: 1426 QQELDDLVVDLDNQRQLVSN 1445



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 94/440 (21%), Positives = 205/440 (46%), Gaps = 53/440 (12%)

Query: 228  RLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNAD--HSKSDRMTRGLRA 285
            R E +    E ++L+  +A  L+ + E +EEL +    ++    D   SK D     +  
Sbjct: 1473 RAEAEAREKETKALS--LARALEEALEAKEELERTNKMLKAEMEDLVSSKDD-----VGK 1525

Query: 286  QVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEA-------LEALQSEKSRIMQDQSE 338
             V +L ++  A ++Q+  +K +L+E +  L    +A       ++AL+ +  R +Q + E
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585

Query: 339  GNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAER 398
             N  + + LQ    +LHE +  L+ E    ++ ++  AA   K+E + ++L      A +
Sbjct: 1586 QNEEKRRQLQ---RQLHEYETELEDE----RKQRALAAAAKKKLEGDLKDLELQADSAIK 1638

Query: 399  KYSDEKKRVDELQQQVKLYKLNLE---SSKQELIDYKQKATRILQSKEKLINSLKEGSGF 455
               +  K++ +LQ Q+K ++  LE   +S+ E+    ++  +  +S E  +  L+E    
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698

Query: 456  EGLDSSTASSMELEELRHE-------KEMQREEIQKLMGQIHQLRSELQD----MEAQQV 504
                   A  +E EEL  E       +   ++E ++L  +I QL  EL++    MEA   
Sbjct: 1699 AERARKQAD-LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS- 1756

Query: 505  NEAESAREQLQDLHDQIAGQKAS-------KQELETELERLKQEFHYIE----EDLYRTK 553
            +    A +Q + L +++A ++++       +Q+LE + + L+ + H +E         T 
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816

Query: 554  NTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKN 613
              L+++I   +E++++   +   K  +  S  + + +L ++   +  ++ M E    +  
Sbjct: 1817 AALEAKIAQLEEQVEQ---EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1873

Query: 614  SLVFQLERLEQQMNSASGSS 633
                ++++L++Q+  A   S
Sbjct: 1874 KGNARVKQLKRQLEEAEEES 1893



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 90/433 (20%), Positives = 185/433 (42%), Gaps = 30/433 (6%)

Query: 279  MTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQ--DQ 336
            M RG  A+     +A A +  QL  +KV  +     L  R      L ++   ++Q   Q
Sbjct: 796  MCRGYLAR-----KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ 850

Query: 337  SEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLA 396
             E    +   LQ  +ER  +A+  LK  ++ + Q+  E      +++ E +  AEA  + 
Sbjct: 851  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910

Query: 397  ERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFE 456
             R  + +K+ ++E+  +++      E   Q+L   ++K  + +   E+ +   +      
Sbjct: 911  VR-LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969

Query: 457  GLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAR----- 511
             L+  TA + ++++L  E  +  ++  KL  +   L   + D+      E E A+     
Sbjct: 970  QLEKVTAEA-KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1028

Query: 512  -----EQLQDLHDQIAGQKASKQELE---TELERLKQEFHYIEEDLYRTKNTLQSRIKDR 563
                   + +L  ++  ++ S+QELE    +LE    +FH    DL      L+ ++  +
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1088

Query: 564  DEEIQ----KLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQL 619
            +EE+Q    +L +++  K  +     ELE  +  L E L  ++        +K  L  +L
Sbjct: 1089 EEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1148

Query: 620  ERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASS 679
            E L+ ++     S++    +        E T L+    L  +T ++ A +    +K A +
Sbjct: 1149 EALKTELEDTLDSTATQQELRAK--REQEVTVLKK--ALDEETRSHEAQVQEMRQKHAQA 1204

Query: 680  IDQFSIRLGIFLR 692
            +++ + +L  F R
Sbjct: 1205 VEELTEQLEQFKR 1217



 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 82/379 (21%), Positives = 164/379 (43%), Gaps = 59/379 (15%)

Query: 223  ELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRG 282
            +L +L L+        +   +++  L  + K+ Q EL  ARA  ++  A   ++++  + 
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684

Query: 283  LRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEK----SRIMQDQSE 338
            L A +  L E +AA +       +  +E  + L++      ALQ EK    +RI Q + E
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744

Query: 339  GNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLN---KVEMERQNLAEAITL 395
                Q   ++   +R+ +A  T + EQ S +       A+ N   + ++ERQN      L
Sbjct: 1745 LEEEQGN-MEAMSDRVRKA--TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1801

Query: 396  AERK---YSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEG 452
             E +    S  K  +  L+ ++   +  +E   +E    KQ AT+ L+ K+K +  +   
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEIL-- 1855

Query: 453  SGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDME--AQQVNEAESA 510
                         +++E+ R   E  +E+ +K   ++ QL+ +L++ E  +Q++N     
Sbjct: 1856 -------------LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN----- 1897

Query: 511  REQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDE-EIQK 569
                           A++++L+ EL+   +      E + R  N L+S+++  +E     
Sbjct: 1898 ---------------ANRRKLQRELDEATES----NEAMGREVNALKSKLRRGNETSFVP 1938

Query: 570  LRNQLTNKTLSNSSQSELE 588
             R     + + N+  SE E
Sbjct: 1939 SRRSGGRRVIENADGSEEE 1957


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 85/430 (19%), Positives = 189/430 (43%), Gaps = 25/430 (5%)

Query: 224  LSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGL 283
            +S L ++    + ++Q     + +L +  K  Q+E+     + E+  A + K ++    L
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432

Query: 284  RAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQ 343
            + ++DDL   +  +   ++ L+ + ++ DQLL+           E+ R   +  E  +  
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492

Query: 344  NQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDE 403
                +  +E L EA   L+R  +  K    +  +  + V      L ++    E +  + 
Sbjct: 1493 LSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551

Query: 404  KKRVDELQQQVKL---YKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDS 460
            K +++EL+ +++     KL LE + Q L   K +  R LQ++++     +     +  + 
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQAL---KGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 461  STASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEA-----QQVNEAESAREQLQ 515
             T    ELE+ R ++ +     +KL G +  L  ELQ   A     + + +    + Q++
Sbjct: 1609 ET----ELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQLRKLQAQMK 1662

Query: 516  DLHDQIAGQKASKQEL-------ETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQ 568
            D   ++   +AS+ E+       E + + L+ +   ++EDL   +   +    +++E  +
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1722

Query: 569  KLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
            +L + L+ +      +  LE R+ QL E L ++Q  +E++S        Q E+L  ++ +
Sbjct: 1723 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782

Query: 629  ASGSSSNGSS 638
               ++    S
Sbjct: 1783 ERSTAQKNES 1792



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 89/426 (20%), Positives = 176/426 (41%), Gaps = 30/426 (7%)

Query: 225  SNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLR 284
            +NL    Q L  E   L  E+  L Q  +E + +  K  A+V++  +  S  +R    L 
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1286

Query: 285  AQVDDLTEAVAAKDSQL--------------AVLKVRLQEADQLLSTRTEALEALQSEKS 330
             +V  L   V +    L              A L  +LQ+  +LL   T       +  +
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK---LNVST 1343

Query: 331  RIMQDQSEGNSLQNQALQTFQ--ERLHEADATLKREQESYKQMQSEFAARLNKVEMERQN 388
            ++ Q + E NSLQ+Q  +  +  + L    +TL  +    K+   +FA+ +  +E  ++ 
Sbjct: 1344 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403

Query: 389  LAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINS 448
              + I    ++Y ++    D+L++     +  L+    +L + +Q  + + + + K    
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463

Query: 449  LKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAE 508
            L E        +      E E    EKE +   + + + +  + + EL+        E E
Sbjct: 1464 LAEEKNISSKYADERDRAEAEA--REKETKALSLARALEEALEAKEELERTNKMLKAEME 1521

Query: 509  SAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQ 568
                   D+   +   + SK+ LET++E +K +   +E++L  T++  + R+   +  +Q
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA-KLRL---EVNMQ 1577

Query: 569  KLRNQLTNKTLSNSSQSE-----LENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLE 623
             L+ Q      +   Q+E     L+ +LH+    L  ++      +  K  L   L+ LE
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1637

Query: 624  QQMNSA 629
             Q +SA
Sbjct: 1638 LQADSA 1643



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 108/476 (22%), Positives = 204/476 (42%), Gaps = 83/476 (17%)

Query: 225  SNLRLENQLLRNEVQSLNQEMAS-------LLQRSKETQEELNKARARVEKWNADHSKSD 277
            S L  E  LL+ ++Q+  +  A        L  + +E +E L++  AR+E+      +  
Sbjct: 890  SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949

Query: 278  RMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQS 337
               + +  Q+ DL E +  ++ + A  K++L++      T    ++ L+ E   +M DQ+
Sbjct: 950  AERKKMAQQMLDLEEQL--EEEEAARQKLQLEKV-----TAEAKIKKLEDE-ILVMDDQN 1001

Query: 338  EGNSLQNQALQTFQERLHEADATLKREQESYKQ----------MQSEFAARLNKVEMERQ 387
               S + + L+   ER+ +    L  E+E  K           M SE   RL K E  RQ
Sbjct: 1002 NKLSKERKLLE---ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1058

Query: 388  NLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQEL----------IDYKQKATR 437
             L +     E   SD  +++ +LQ Q+   K+ L   ++EL          I  K  A +
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118

Query: 438  ILQSKEKLINSLKE-------------------GSGFEG----LDSSTASSMELEELRHE 474
             ++  E  I+ L+E                   G   E     L+ +  S+   +ELR +
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1178

Query: 475  KEMQREEIQKLMG-QIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELET 533
            +E +   ++K +  +     +++Q+M  +     E   EQL+      A    +KQ LE 
Sbjct: 1179 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1238

Query: 534  E----------LERLKQEFHYIEEDLYRTKNTLQSRIKDRD-------EEIQKLRNQLTN 576
            E          L + KQE  + ++ L      LQS+  D +       +++ KL+N++ +
Sbjct: 1239 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1298

Query: 577  KT-LSNSSQS---ELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
             T + N ++    +L   +  L+  L   Q +L+  + +K ++  +L +LE++ NS
Sbjct: 1299 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1354



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 100/404 (24%), Positives = 177/404 (43%), Gaps = 45/404 (11%)

Query: 237  EVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAA 296
            +V    +EM +     ++T+E   KA   +++    HS+       L+ Q+   TE  A 
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 297  KDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHE 356
             +     L  + QE +++L    E    L+ E+ R  Q Q+E   +  Q L   +E+L E
Sbjct: 913  AEEMRVRLAAKKQELEEILH---EMEARLEEEEDRGQQLQAERKKMAQQMLD-LEEQLEE 968

Query: 357  ADATLKREQ-------ESYKQMQSEFAA---RLNKVEMERQNLAEAITLAERKYSDEKKR 406
             +A  ++ Q          K+++ E      + NK+  ER+ L E I+      ++E+++
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028

Query: 407  VDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSM 466
               L +     K   ES   EL    +K  +  Q  EKL   L EG   +  +       
Sbjct: 1029 AKNLTK----LKNKHESMISELEVRLKKEEKSRQELEKLKRKL-EGDASDFHEQIADLQA 1083

Query: 467  ELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESARE---QLQDLHDQIAG 523
            ++ EL+ +   + EE+Q  +       + L D  AQ+ N  +  RE    + DL + +  
Sbjct: 1084 QIAELKMQLAKKEEELQAAL-------ARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136

Query: 524  QKAS-------KQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTN 576
            ++A+       K++L  ELE LK E   +E+ L  T    + R K R++E+  L+  L  
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTE---LEDTLDSTATQQELRAK-REQEVTVLKKALDE 1192

Query: 577  KTLSNSSQSELENRLH-----QLTETLIQKQTMLESLSTEKNSL 615
            +T S+ +Q +   + H     +LTE L Q +    +L   K +L
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 84/440 (19%), Positives = 180/440 (40%), Gaps = 60/440 (13%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEA 293
            L+N+ +S+  E+   L++ +++++EL K + ++E    D S        L+AQ+ +L   
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLE---GDASDFHEQIADLQAQIAELKMQ 1091

Query: 294  VAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQA------- 346
            +A K+ +L     RL +     +   + +  L+   S + +D     + +N+A       
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 347  ---LQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDE 403
               L+  +  L +   +   +QE   + + E       ++ E ++    +    +K++  
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 404  KKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTA 463
             + + E  +Q K  K NL+ +KQ L    +K    L  + +++   K+            
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTL----EKENADLAGELRVLGQAKQ------------ 1255

Query: 464  SSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESA------------- 510
               E+E  + + E Q +E+Q       + R+EL D   +  NE ES              
Sbjct: 1256 ---EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312

Query: 511  --------REQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDL---YRTKNTLQSR 559
                      QLQD  + +  +   K  + T+L +L++E + +++ L      K  L+  
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372

Query: 560  IKDRDEEI----QKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSL 615
            I   + ++    +KL++  +        +   +  +  LT+   +K    + L   KN L
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432

Query: 616  VFQLERLEQQMNSASGSSSN 635
              +L+ L   +++     SN
Sbjct: 1433 QQELDDLVVDLDNQRQLVSN 1452



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 94/440 (21%), Positives = 205/440 (46%), Gaps = 53/440 (12%)

Query: 228  RLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNAD--HSKSDRMTRGLRA 285
            R E +    E ++L+  +A  L+ + E +EEL +    ++    D   SK D     +  
Sbjct: 1480 RAEAEAREKETKALS--LARALEEALEAKEELERTNKMLKAEMEDLVSSKDD-----VGK 1532

Query: 286  QVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEA-------LEALQSEKSRIMQDQSE 338
             V +L ++  A ++Q+  +K +L+E +  L    +A       ++AL+ +  R +Q + E
Sbjct: 1533 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592

Query: 339  GNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAER 398
             N  + + LQ    +LHE +  L+ E    ++ ++  AA   K+E + ++L      A +
Sbjct: 1593 QNEEKRRQLQ---RQLHEYETELEDE----RKQRALAAAAKKKLEGDLKDLELQADSAIK 1645

Query: 399  KYSDEKKRVDELQQQVKLYKLNLE---SSKQELIDYKQKATRILQSKEKLINSLKEGSGF 455
               +  K++ +LQ Q+K ++  LE   +S+ E+    ++  +  +S E  +  L+E    
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705

Query: 456  EGLDSSTASSMELEELRHE-------KEMQREEIQKLMGQIHQLRSELQD----MEAQQV 504
                   A  +E EEL  E       +   ++E ++L  +I QL  EL++    MEA   
Sbjct: 1706 AERARKQAD-LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS- 1763

Query: 505  NEAESAREQLQDLHDQIAGQKAS-------KQELETELERLKQEFHYIE----EDLYRTK 553
            +    A +Q + L +++A ++++       +Q+LE + + L+ + H +E         T 
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823

Query: 554  NTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKN 613
              L+++I   +E++++   +   K  +  S  + + +L ++   +  ++ M E    +  
Sbjct: 1824 AALEAKIAQLEEQVEQ---EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880

Query: 614  SLVFQLERLEQQMNSASGSS 633
                ++++L++Q+  A   S
Sbjct: 1881 KGNARVKQLKRQLEEAEEES 1900



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 90/433 (20%), Positives = 185/433 (42%), Gaps = 30/433 (6%)

Query: 279  MTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQ--DQ 336
            M RG  A+     +A A +  QL  +KV  +     L  R      L ++   ++Q   Q
Sbjct: 803  MCRGYLAR-----KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ 857

Query: 337  SEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLA 396
             E    +   LQ  +ER  +A+  LK  ++ + Q+  E      +++ E +  AEA  + 
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917

Query: 397  ERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFE 456
             R  + +K+ ++E+  +++      E   Q+L   ++K  + +   E+ +   +      
Sbjct: 918  VR-LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976

Query: 457  GLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAR----- 511
             L+  TA + ++++L  E  +  ++  KL  +   L   + D+      E E A+     
Sbjct: 977  QLEKVTAEA-KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1035

Query: 512  -----EQLQDLHDQIAGQKASKQELE---TELERLKQEFHYIEEDLYRTKNTLQSRIKDR 563
                   + +L  ++  ++ S+QELE    +LE    +FH    DL      L+ ++  +
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1095

Query: 564  DEEIQ----KLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQL 619
            +EE+Q    +L +++  K  +     ELE  +  L E L  ++        +K  L  +L
Sbjct: 1096 EEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1155

Query: 620  ERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASS 679
            E L+ ++     S++    +        E T L+    L  +T ++ A +    +K A +
Sbjct: 1156 EALKTELEDTLDSTATQQELRAK--REQEVTVLKK--ALDEETRSHEAQVQEMRQKHAQA 1211

Query: 680  IDQFSIRLGIFLR 692
            +++ + +L  F R
Sbjct: 1212 VEELTEQLEQFKR 1224



 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 82/379 (21%), Positives = 164/379 (43%), Gaps = 59/379 (15%)

Query: 223  ELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRG 282
            +L +L L+        +   +++  L  + K+ Q EL  ARA  ++  A   ++++  + 
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691

Query: 283  LRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEK----SRIMQDQSE 338
            L A +  L E +AA +       +  +E  + L++      ALQ EK    +RI Q + E
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751

Query: 339  GNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLN---KVEMERQNLAEAITL 395
                Q   ++   +R+ +A  T + EQ S +       A+ N   + ++ERQN      L
Sbjct: 1752 LEEEQGN-MEAMSDRVRKA--TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1808

Query: 396  AERK---YSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEG 452
             E +    S  K  +  L+ ++   +  +E   +E    KQ AT+ L+ K+K +  +   
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEIL-- 1862

Query: 453  SGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDME--AQQVNEAESA 510
                         +++E+ R   E  +E+ +K   ++ QL+ +L++ E  +Q++N     
Sbjct: 1863 -------------LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN----- 1904

Query: 511  REQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDE-EIQK 569
                           A++++L+ EL+   +      E + R  N L+S+++  +E     
Sbjct: 1905 ---------------ANRRKLQRELDEATES----NEAMGREVNALKSKLRRGNETSFVP 1945

Query: 570  LRNQLTNKTLSNSSQSELE 588
             R     + + N+  SE E
Sbjct: 1946 SRRSGGRRVIENADGSEEE 1964


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 85/430 (19%), Positives = 189/430 (43%), Gaps = 25/430 (5%)

Query: 224  LSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGL 283
            +S L ++    + ++Q     + +L +  K  Q+E+     + E+  A + K ++    L
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432

Query: 284  RAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQ 343
            + ++DDL   +  +   ++ L+ + ++ DQLL+           E+ R   +  E  +  
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492

Query: 344  NQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDE 403
                +  +E L EA   L+R  +  K    +  +  + V      L ++    E +  + 
Sbjct: 1493 LSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551

Query: 404  KKRVDELQQQVKL---YKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDS 460
            K +++EL+ +++     KL LE + Q L   K +  R LQ++++     +     +  + 
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQAL---KGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 461  STASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEA-----QQVNEAESAREQLQ 515
             T    ELE+ R ++ +     +KL G +  L  ELQ   A     + + +    + Q++
Sbjct: 1609 ET----ELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQLRKLQAQMK 1662

Query: 516  DLHDQIAGQKASKQEL-------ETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQ 568
            D   ++   +AS+ E+       E + + L+ +   ++EDL   +   +    +++E  +
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1722

Query: 569  KLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
            +L + L+ +      +  LE R+ QL E L ++Q  +E++S        Q E+L  ++ +
Sbjct: 1723 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782

Query: 629  ASGSSSNGSS 638
               ++    S
Sbjct: 1783 ERSTAQKNES 1792



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 89/426 (20%), Positives = 176/426 (41%), Gaps = 30/426 (7%)

Query: 225  SNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLR 284
            +NL    Q L  E   L  E+  L Q  +E + +  K  A+V++  +  S  +R    L 
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1286

Query: 285  AQVDDLTEAVAAKDSQL--------------AVLKVRLQEADQLLSTRTEALEALQSEKS 330
             +V  L   V +    L              A L  +LQ+  +LL   T       +  +
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK---LNVST 1343

Query: 331  RIMQDQSEGNSLQNQALQTFQ--ERLHEADATLKREQESYKQMQSEFAARLNKVEMERQN 388
            ++ Q + E NSLQ+Q  +  +  + L    +TL  +    K+   +FA+ +  +E  ++ 
Sbjct: 1344 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403

Query: 389  LAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINS 448
              + I    ++Y ++    D+L++     +  L+    +L + +Q  + + + + K    
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463

Query: 449  LKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAE 508
            L E        +      E E    EKE +   + + + +  + + EL+        E E
Sbjct: 1464 LAEEKNISSKYADERDRAEAEA--REKETKALSLARALEEALEAKEELERTNKMLKAEME 1521

Query: 509  SAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQ 568
                   D+   +   + SK+ LET++E +K +   +E++L  T++  + R+   +  +Q
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA-KLRL---EVNMQ 1577

Query: 569  KLRNQLTNKTLSNSSQSE-----LENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLE 623
             L+ Q      +   Q+E     L+ +LH+    L  ++      +  K  L   L+ LE
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1637

Query: 624  QQMNSA 629
             Q +SA
Sbjct: 1638 LQADSA 1643



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 108/476 (22%), Positives = 204/476 (42%), Gaps = 83/476 (17%)

Query: 225  SNLRLENQLLRNEVQSLNQEMAS-------LLQRSKETQEELNKARARVEKWNADHSKSD 277
            S L  E  LL+ ++Q+  +  A        L  + +E +E L++  AR+E+      +  
Sbjct: 890  SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949

Query: 278  RMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQS 337
               + +  Q+ DL E +  ++ + A  K++L++      T    ++ L+ E   +M DQ+
Sbjct: 950  AERKKMAQQMLDLEEQL--EEEEAARQKLQLEKV-----TAEAKIKKLEDE-ILVMDDQN 1001

Query: 338  EGNSLQNQALQTFQERLHEADATLKREQESYKQ----------MQSEFAARLNKVEMERQ 387
               S + + L+   ER+ +    L  E+E  K           M SE   RL K E  RQ
Sbjct: 1002 NKLSKERKLLE---ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1058

Query: 388  NLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQEL----------IDYKQKATR 437
             L +     E   SD  +++ +LQ Q+   K+ L   ++EL          I  K  A +
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118

Query: 438  ILQSKEKLINSLKE-------------------GSGFEG----LDSSTASSMELEELRHE 474
             ++  E  I+ L+E                   G   E     L+ +  S+   +ELR +
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1178

Query: 475  KEMQREEIQKLMG-QIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELET 533
            +E +   ++K +  +     +++Q+M  +     E   EQL+      A    +KQ LE 
Sbjct: 1179 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1238

Query: 534  E----------LERLKQEFHYIEEDLYRTKNTLQSRIKDRD-------EEIQKLRNQLTN 576
            E          L + KQE  + ++ L      LQS+  D +       +++ KL+N++ +
Sbjct: 1239 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1298

Query: 577  KT-LSNSSQS---ELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
             T + N ++    +L   +  L+  L   Q +L+  + +K ++  +L +LE++ NS
Sbjct: 1299 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1354



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 100/404 (24%), Positives = 177/404 (43%), Gaps = 45/404 (11%)

Query: 237  EVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAA 296
            +V    +EM +     ++T+E   KA   +++    HS+       L+ Q+   TE  A 
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 297  KDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHE 356
             +     L  + QE +++L    E    L+ E+ R  Q Q+E   +  Q L   +E+L E
Sbjct: 913  AEEMRVRLAAKKQELEEILH---EMEARLEEEEDRGQQLQAERKKMAQQMLD-LEEQLEE 968

Query: 357  ADATLKREQ-------ESYKQMQSEFAA---RLNKVEMERQNLAEAITLAERKYSDEKKR 406
             +A  ++ Q          K+++ E      + NK+  ER+ L E I+      ++E+++
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028

Query: 407  VDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSM 466
               L +     K   ES   EL    +K  +  Q  EKL   L EG   +  +       
Sbjct: 1029 AKNLTK----LKNKHESMISELEVRLKKEEKSRQELEKLKRKL-EGDASDFHEQIADLQA 1083

Query: 467  ELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESARE---QLQDLHDQIAG 523
            ++ EL+ +   + EE+Q  +       + L D  AQ+ N  +  RE    + DL + +  
Sbjct: 1084 QIAELKMQLAKKEEELQAAL-------ARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136

Query: 524  QKAS-------KQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTN 576
            ++A+       K++L  ELE LK E   +E+ L  T    + R K R++E+  L+  L  
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTE---LEDTLDSTATQQELRAK-REQEVTVLKKALDE 1192

Query: 577  KTLSNSSQSELENRLH-----QLTETLIQKQTMLESLSTEKNSL 615
            +T S+ +Q +   + H     +LTE L Q +    +L   K +L
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 84/440 (19%), Positives = 180/440 (40%), Gaps = 60/440 (13%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEA 293
            L+N+ +S+  E+   L++ +++++EL K + ++E    D S        L+AQ+ +L   
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLE---GDASDFHEQIADLQAQIAELKMQ 1091

Query: 294  VAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQA------- 346
            +A K+ +L     RL +     +   + +  L+   S + +D     + +N+A       
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 347  ---LQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDE 403
               L+  +  L +   +   +QE   + + E       ++ E ++    +    +K++  
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 404  KKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTA 463
             + + E  +Q K  K NL+ +KQ L    +K    L  + +++   K+            
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTL----EKENADLAGELRVLGQAKQ------------ 1255

Query: 464  SSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESA------------- 510
               E+E  + + E Q +E+Q       + R+EL D   +  NE ES              
Sbjct: 1256 ---EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312

Query: 511  --------REQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDL---YRTKNTLQSR 559
                      QLQD  + +  +   K  + T+L +L++E + +++ L      K  L+  
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372

Query: 560  IKDRDEEI----QKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSL 615
            I   + ++    +KL++  +        +   +  +  LT+   +K    + L   KN L
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432

Query: 616  VFQLERLEQQMNSASGSSSN 635
              +L+ L   +++     SN
Sbjct: 1433 QQELDDLVVDLDNQRQLVSN 1452



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 94/440 (21%), Positives = 205/440 (46%), Gaps = 53/440 (12%)

Query: 228  RLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNAD--HSKSDRMTRGLRA 285
            R E +    E ++L+  +A  L+ + E +EEL +    ++    D   SK D     +  
Sbjct: 1480 RAEAEAREKETKALS--LARALEEALEAKEELERTNKMLKAEMEDLVSSKDD-----VGK 1532

Query: 286  QVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEA-------LEALQSEKSRIMQDQSE 338
             V +L ++  A ++Q+  +K +L+E +  L    +A       ++AL+ +  R +Q + E
Sbjct: 1533 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592

Query: 339  GNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAER 398
             N  + + LQ    +LHE +  L+ E    ++ ++  AA   K+E + ++L      A +
Sbjct: 1593 QNEEKRRQLQ---RQLHEYETELEDE----RKQRALAAAAKKKLEGDLKDLELQADSAIK 1645

Query: 399  KYSDEKKRVDELQQQVKLYKLNLE---SSKQELIDYKQKATRILQSKEKLINSLKEGSGF 455
               +  K++ +LQ Q+K ++  LE   +S+ E+    ++  +  +S E  +  L+E    
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705

Query: 456  EGLDSSTASSMELEELRHE-------KEMQREEIQKLMGQIHQLRSELQD----MEAQQV 504
                   A  +E EEL  E       +   ++E ++L  +I QL  EL++    MEA   
Sbjct: 1706 AERARKQAD-LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS- 1763

Query: 505  NEAESAREQLQDLHDQIAGQKAS-------KQELETELERLKQEFHYIE----EDLYRTK 553
            +    A +Q + L +++A ++++       +Q+LE + + L+ + H +E         T 
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823

Query: 554  NTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKN 613
              L+++I   +E++++   +   K  +  S  + + +L ++   +  ++ M E    +  
Sbjct: 1824 AALEAKIAQLEEQVEQ---EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880

Query: 614  SLVFQLERLEQQMNSASGSS 633
                ++++L++Q+  A   S
Sbjct: 1881 KGNARVKQLKRQLEEAEEES 1900



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 90/433 (20%), Positives = 185/433 (42%), Gaps = 30/433 (6%)

Query: 279  MTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQ--DQ 336
            M RG  A+     +A A +  QL  +KV  +     L  R      L ++   ++Q   Q
Sbjct: 803  MCRGYLAR-----KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ 857

Query: 337  SEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLA 396
             E    +   LQ  +ER  +A+  LK  ++ + Q+  E      +++ E +  AEA  + 
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917

Query: 397  ERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFE 456
             R  + +K+ ++E+  +++      E   Q+L   ++K  + +   E+ +   +      
Sbjct: 918  VR-LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976

Query: 457  GLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAR----- 511
             L+  TA + ++++L  E  +  ++  KL  +   L   + D+      E E A+     
Sbjct: 977  QLEKVTAEA-KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1035

Query: 512  -----EQLQDLHDQIAGQKASKQELE---TELERLKQEFHYIEEDLYRTKNTLQSRIKDR 563
                   + +L  ++  ++ S+QELE    +LE    +FH    DL      L+ ++  +
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1095

Query: 564  DEEIQ----KLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQL 619
            +EE+Q    +L +++  K  +     ELE  +  L E L  ++        +K  L  +L
Sbjct: 1096 EEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1155

Query: 620  ERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASS 679
            E L+ ++     S++    +        E T L+    L  +T ++ A +    +K A +
Sbjct: 1156 EALKTELEDTLDSTATQQELRAK--REQEVTVLKK--ALDEETRSHEAQVQEMRQKHAQA 1211

Query: 680  IDQFSIRLGIFLR 692
            +++ + +L  F R
Sbjct: 1212 VEELTEQLEQFKR 1224



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 76/351 (21%), Positives = 154/351 (43%), Gaps = 58/351 (16%)

Query: 223  ELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRG 282
            +L +L L+        +   +++  L  + K+ Q EL  ARA  ++  A   ++++  + 
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691

Query: 283  LRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEK----SRIMQDQSE 338
            L A +  L E +AA +       +  +E  + L++      ALQ EK    +RI Q + E
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751

Query: 339  GNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLN---KVEMERQNLAEAITL 395
                Q   ++   +R+ +A  T + EQ S +       A+ N   + ++ERQN      L
Sbjct: 1752 LEEEQGN-MEAMSDRVRKA--TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1808

Query: 396  AERK---YSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEG 452
             E +    S  K  +  L+ ++   +  +E   +E    KQ AT+ L+ K+K +  +   
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEIL-- 1862

Query: 453  SGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDME--AQQVNEAESA 510
                         +++E+ R   E  +E+ +K   ++ QL+ +L++ E  +Q++N     
Sbjct: 1863 -------------LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN----- 1904

Query: 511  REQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIK 561
                           A++++L+ EL+   +      E + R  N L+S+++
Sbjct: 1905 ---------------ANRRKLQRELDEATES----NEAMGREVNALKSKLR 1936


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 85/430 (19%), Positives = 189/430 (43%), Gaps = 25/430 (5%)

Query: 224  LSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGL 283
            +S L ++    + ++Q     + +L +  K  Q+E+     + E+  A + K ++    L
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425

Query: 284  RAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQ 343
            + ++DDL   +  +   ++ L+ + ++ DQLL+           E+ R   +  E  +  
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485

Query: 344  NQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDE 403
                +  +E L EA   L+R  +  K    +  +  + V      L ++    E +  + 
Sbjct: 1486 LSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544

Query: 404  KKRVDELQQQVKL---YKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDS 460
            K +++EL+ +++     KL LE + Q L   K +  R LQ++++     +     +  + 
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQAL---KGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 461  STASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEA-----QQVNEAESAREQLQ 515
             T    ELE+ R ++ +     +KL G +  L  ELQ   A     + + +    + Q++
Sbjct: 1602 ET----ELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQLRKLQAQMK 1655

Query: 516  DLHDQIAGQKASKQEL-------ETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQ 568
            D   ++   +AS+ E+       E + + L+ +   ++EDL   +   +    +++E  +
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1715

Query: 569  KLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
            +L + L+ +      +  LE R+ QL E L ++Q  +E++S        Q E+L  ++ +
Sbjct: 1716 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775

Query: 629  ASGSSSNGSS 638
               ++    S
Sbjct: 1776 ERSTAQKNES 1785



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 89/426 (20%), Positives = 176/426 (41%), Gaps = 30/426 (7%)

Query: 225  SNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLR 284
            +NL    Q L  E   L  E+  L Q  +E + +  K  A+V++  +  S  +R    L 
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1279

Query: 285  AQVDDLTEAVAAKDSQL--------------AVLKVRLQEADQLLSTRTEALEALQSEKS 330
             +V  L   V +    L              A L  +LQ+  +LL   T       +  +
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK---LNVST 1336

Query: 331  RIMQDQSEGNSLQNQALQTFQ--ERLHEADATLKREQESYKQMQSEFAARLNKVEMERQN 388
            ++ Q + E NSLQ+Q  +  +  + L    +TL  +    K+   +FA+ +  +E  ++ 
Sbjct: 1337 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396

Query: 389  LAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINS 448
              + I    ++Y ++    D+L++     +  L+    +L + +Q  + + + + K    
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456

Query: 449  LKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAE 508
            L E        +      E E    EKE +   + + + +  + + EL+        E E
Sbjct: 1457 LAEEKNISSKYADERDRAEAEA--REKETKALSLARALEEALEAKEELERTNKMLKAEME 1514

Query: 509  SAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQ 568
                   D+   +   + SK+ LET++E +K +   +E++L  T++  + R+   +  +Q
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA-KLRL---EVNMQ 1570

Query: 569  KLRNQLTNKTLSNSSQSE-----LENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLE 623
             L+ Q      +   Q+E     L+ +LH+    L  ++      +  K  L   L+ LE
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1630

Query: 624  QQMNSA 629
             Q +SA
Sbjct: 1631 LQADSA 1636



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 108/476 (22%), Positives = 204/476 (42%), Gaps = 83/476 (17%)

Query: 225  SNLRLENQLLRNEVQSLNQEMAS-------LLQRSKETQEELNKARARVEKWNADHSKSD 277
            S L  E  LL+ ++Q+  +  A        L  + +E +E L++  AR+E+      +  
Sbjct: 883  SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942

Query: 278  RMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQS 337
               + +  Q+ DL E +  ++ + A  K++L++      T    ++ L+ E   +M DQ+
Sbjct: 943  AERKKMAQQMLDLEEQL--EEEEAARQKLQLEKV-----TAEAKIKKLEDE-ILVMDDQN 994

Query: 338  EGNSLQNQALQTFQERLHEADATLKREQESYKQ----------MQSEFAARLNKVEMERQ 387
               S + + L+   ER+ +    L  E+E  K           M SE   RL K E  RQ
Sbjct: 995  NKLSKERKLLE---ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051

Query: 388  NLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQEL----------IDYKQKATR 437
             L +     E   SD  +++ +LQ Q+   K+ L   ++EL          I  K  A +
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1111

Query: 438  ILQSKEKLINSLKE-------------------GSGFEG----LDSSTASSMELEELRHE 474
             ++  E  I+ L+E                   G   E     L+ +  S+   +ELR +
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1171

Query: 475  KEMQREEIQKLMG-QIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELET 533
            +E +   ++K +  +     +++Q+M  +     E   EQL+      A    +KQ LE 
Sbjct: 1172 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1231

Query: 534  E----------LERLKQEFHYIEEDLYRTKNTLQSRIKDRD-------EEIQKLRNQLTN 576
            E          L + KQE  + ++ L      LQS+  D +       +++ KL+N++ +
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1291

Query: 577  KT-LSNSSQS---ELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
             T + N ++    +L   +  L+  L   Q +L+  + +K ++  +L +LE++ NS
Sbjct: 1292 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1347



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 100/404 (24%), Positives = 177/404 (43%), Gaps = 45/404 (11%)

Query: 237  EVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAA 296
            +V    +EM +     ++T+E   KA   +++    HS+       L+ Q+   TE  A 
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 297  KDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHE 356
             +     L  + QE +++L    E    L+ E+ R  Q Q+E   +  Q L   +E+L E
Sbjct: 906  AEEMRVRLAAKKQELEEILH---EMEARLEEEEDRGQQLQAERKKMAQQMLD-LEEQLEE 961

Query: 357  ADATLKREQ-------ESYKQMQSEFAA---RLNKVEMERQNLAEAITLAERKYSDEKKR 406
             +A  ++ Q          K+++ E      + NK+  ER+ L E I+      ++E+++
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021

Query: 407  VDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSM 466
               L +     K   ES   EL    +K  +  Q  EKL   L EG   +  +       
Sbjct: 1022 AKNLTK----LKNKHESMISELEVRLKKEEKSRQELEKLKRKL-EGDASDFHEQIADLQA 1076

Query: 467  ELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESARE---QLQDLHDQIAG 523
            ++ EL+ +   + EE+Q  +       + L D  AQ+ N  +  RE    + DL + +  
Sbjct: 1077 QIAELKMQLAKKEEELQAAL-------ARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129

Query: 524  QKAS-------KQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTN 576
            ++A+       K++L  ELE LK E   +E+ L  T    + R K R++E+  L+  L  
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTE---LEDTLDSTATQQELRAK-REQEVTVLKKALDE 1185

Query: 577  KTLSNSSQSELENRLH-----QLTETLIQKQTMLESLSTEKNSL 615
            +T S+ +Q +   + H     +LTE L Q +    +L   K +L
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 84/440 (19%), Positives = 180/440 (40%), Gaps = 60/440 (13%)

Query: 234  LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEA 293
            L+N+ +S+  E+   L++ +++++EL K + ++E    D S        L+AQ+ +L   
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLE---GDASDFHEQIADLQAQIAELKMQ 1084

Query: 294  VAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQA------- 346
            +A K+ +L     RL +     +   + +  L+   S + +D     + +N+A       
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 347  ---LQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDE 403
               L+  +  L +   +   +QE   + + E       ++ E ++    +    +K++  
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204

Query: 404  KKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTA 463
             + + E  +Q K  K NL+ +KQ L    +K    L  + +++   K+            
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTL----EKENADLAGELRVLGQAKQ------------ 1248

Query: 464  SSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESA------------- 510
               E+E  + + E Q +E+Q       + R+EL D   +  NE ES              
Sbjct: 1249 ---EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305

Query: 511  --------REQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDL---YRTKNTLQSR 559
                      QLQD  + +  +   K  + T+L +L++E + +++ L      K  L+  
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365

Query: 560  IKDRDEEI----QKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSL 615
            I   + ++    +KL++  +        +   +  +  LT+   +K    + L   KN L
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425

Query: 616  VFQLERLEQQMNSASGSSSN 635
              +L+ L   +++     SN
Sbjct: 1426 QQELDDLVVDLDNQRQLVSN 1445



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 94/440 (21%), Positives = 205/440 (46%), Gaps = 53/440 (12%)

Query: 228  RLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNAD--HSKSDRMTRGLRA 285
            R E +    E ++L+  +A  L+ + E +EEL +    ++    D   SK D     +  
Sbjct: 1473 RAEAEAREKETKALS--LARALEEALEAKEELERTNKMLKAEMEDLVSSKDD-----VGK 1525

Query: 286  QVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEA-------LEALQSEKSRIMQDQSE 338
             V +L ++  A ++Q+  +K +L+E +  L    +A       ++AL+ +  R +Q + E
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585

Query: 339  GNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAER 398
             N  + + LQ    +LHE +  L+ E    ++ ++  AA   K+E + ++L      A +
Sbjct: 1586 QNEEKRRQLQ---RQLHEYETELEDE----RKQRALAAAAKKKLEGDLKDLELQADSAIK 1638

Query: 399  KYSDEKKRVDELQQQVKLYKLNLE---SSKQELIDYKQKATRILQSKEKLINSLKEGSGF 455
               +  K++ +LQ Q+K ++  LE   +S+ E+    ++  +  +S E  +  L+E    
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698

Query: 456  EGLDSSTASSMELEELRHE-------KEMQREEIQKLMGQIHQLRSELQD----MEAQQV 504
                   A  +E EEL  E       +   ++E ++L  +I QL  EL++    MEA   
Sbjct: 1699 AERARKQAD-LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS- 1756

Query: 505  NEAESAREQLQDLHDQIAGQKAS-------KQELETELERLKQEFHYIE----EDLYRTK 553
            +    A +Q + L +++A ++++       +Q+LE + + L+ + H +E         T 
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816

Query: 554  NTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKN 613
              L+++I   +E++++   +   K  +  S  + + +L ++   +  ++ M E    +  
Sbjct: 1817 AALEAKIAQLEEQVEQ---EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1873

Query: 614  SLVFQLERLEQQMNSASGSS 633
                ++++L++Q+  A   S
Sbjct: 1874 KGNARVKQLKRQLEEAEEES 1893



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 90/433 (20%), Positives = 185/433 (42%), Gaps = 30/433 (6%)

Query: 279  MTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQ--DQ 336
            M RG  A+     +A A +  QL  +KV  +     L  R      L ++   ++Q   Q
Sbjct: 796  MCRGYLAR-----KAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ 850

Query: 337  SEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLA 396
             E    +   LQ  +ER  +A+  LK  ++ + Q+  E      +++ E +  AEA  + 
Sbjct: 851  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910

Query: 397  ERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFE 456
             R  + +K+ ++E+  +++      E   Q+L   ++K  + +   E+ +   +      
Sbjct: 911  VR-LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969

Query: 457  GLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAR----- 511
             L+  TA + ++++L  E  +  ++  KL  +   L   + D+      E E A+     
Sbjct: 970  QLEKVTAEA-KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1028

Query: 512  -----EQLQDLHDQIAGQKASKQELE---TELERLKQEFHYIEEDLYRTKNTLQSRIKDR 563
                   + +L  ++  ++ S+QELE    +LE    +FH    DL      L+ ++  +
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1088

Query: 564  DEEIQ----KLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQL 619
            +EE+Q    +L +++  K  +     ELE  +  L E L  ++        +K  L  +L
Sbjct: 1089 EEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1148

Query: 620  ERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASS 679
            E L+ ++     S++    +        E T L+    L  +T ++ A +    +K A +
Sbjct: 1149 EALKTELEDTLDSTATQQELRAK--REQEVTVLKK--ALDEETRSHEAQVQEMRQKHAQA 1204

Query: 680  IDQFSIRLGIFLR 692
            +++ + +L  F R
Sbjct: 1205 VEELTEQLEQFKR 1217



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 76/351 (21%), Positives = 154/351 (43%), Gaps = 58/351 (16%)

Query: 223  ELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRG 282
            +L +L L+        +   +++  L  + K+ Q EL  ARA  ++  A   ++++  + 
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684

Query: 283  LRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEK----SRIMQDQSE 338
            L A +  L E +AA +       +  +E  + L++      ALQ EK    +RI Q + E
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744

Query: 339  GNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLN---KVEMERQNLAEAITL 395
                Q   ++   +R+ +A  T + EQ S +       A+ N   + ++ERQN      L
Sbjct: 1745 LEEEQGN-MEAMSDRVRKA--TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1801

Query: 396  AERK---YSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEG 452
             E +    S  K  +  L+ ++   +  +E   +E    KQ AT+ L+ K+K +  +   
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEIL-- 1855

Query: 453  SGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDME--AQQVNEAESA 510
                         +++E+ R   E  +E+ +K   ++ QL+ +L++ E  +Q++N     
Sbjct: 1856 -------------LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN----- 1897

Query: 511  REQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIK 561
                           A++++L+ EL+   +      E + R  N L+S+++
Sbjct: 1898 ---------------ANRRKLQRELDEATES----NEAMGREVNALKSKLR 1929


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 112/567 (19%), Positives = 238/567 (41%), Gaps = 45/567 (7%)

Query: 94   ASHPVENASVPRPSSHFVRRKKSEPDDELLFDFLNSSQ--KEPTGRVEIRKEKGK--TPV 149
            ++ P  + SVP   S      K     + + ++L      KE    +E  K+K K  +  
Sbjct: 1806 STRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQT 1865

Query: 150  FQSSQTSSVSSVNPSVTTIKTIEE-----NSFGSQTHEAASNSDSSHEGQEESSKENVSS 204
             ++ + + +S ++     +K ++E     N    Q  E  S      E  EE  K+++  
Sbjct: 1866 LENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEE-KDDLEE 1924

Query: 205  NAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARA 264
                       +      ++++ +++N+LL +E+++L + ++ L +  ++  +E  K  +
Sbjct: 1925 RLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVES 1984

Query: 265  RVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLK---VRLQEADQLLSTRTEA 321
             + K   +  +  +   G ++   +L E +  K  ++  L+   +R QE    L    +A
Sbjct: 1985 EIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKA 2044

Query: 322  LEALQSEKSRIMQDQSEGNSLQNQALQTFQERL-----------HEADATLKREQESYKQ 370
            LE +Q+E  + ++   E  +   +  +  Q  L            EA   L    +  K+
Sbjct: 2045 LEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKE 2104

Query: 371  MQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELID 430
            +QS   +  ++++ + ++L   +  AE K+  EKK + E    ++  K++LE +  E+  
Sbjct: 2105 LQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEI-- 2162

Query: 431  YKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIH 490
                    L  K+K +  L+     E LDS+     +L          +++  +++ +  
Sbjct: 2163 -----QVTLNKKDKEVQQLQ-----ENLDSTVT---QLAAFTKSMSSLQDDRDRVIDEAK 2209

Query: 491  QLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLY 550
            +   +  D    +  E     +    L DQ+       +EL+  + RL+ +   I E   
Sbjct: 2210 KWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHD-KQIWESKA 2268

Query: 551  RTKNTLQSRIKDR-DEEIQKLRNQL-TNKTLSNSSQSE---LENRLHQLTETLIQKQTML 605
            +T+  LQ ++ D    E ++L +QL   + L +SSQ+E   LE+ L  L + L      L
Sbjct: 2269 QTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSL 2328

Query: 606  ESLSTEKNSLVFQLERLEQQMNSASGS 632
            E    +K +L   + + E  + ++  S
Sbjct: 2329 EKCKEQKGNLEGIIRQQEADIQNSKFS 2355



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 109/498 (21%), Positives = 221/498 (44%), Gaps = 41/498 (8%)

Query: 173  ENSFGSQTHEAASNSDSSHEGQEESSKENVS-SNAACPDHTPTPNDDGKSHELSNLRLEN 231
            E    S T E    S+   + QE+ +K+ +   +     H    + +    +L + +L+ 
Sbjct: 1322 ELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQI 1381

Query: 232  QLLRN--EVQSLNQEMASLLQRSKETQE----ELNKARARVEKWNADHSKSDRMTRGLRA 285
              L +  E+Q    E+  L+ + +E       +L++  A + K   +  + + + + L  
Sbjct: 1382 AGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHT 1441

Query: 286  QVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQ 345
            Q++   +    +  QL V    +++  + +   + A + +Q +    +  + E    +N+
Sbjct: 1442 QLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALK-ENK 1500

Query: 346  ALQTFQERLHEADATLKREQESYKQMQSEFAAR-------LNKVEMERQNLAEAITLAER 398
            +LQ   E L  A  T++R  +S   ++S+ +A+       L ++ + ++   + IT  +R
Sbjct: 1501 SLQ---EELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDR 1557

Query: 399  KYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQ--KATRILQSKEKLINSLKEGSGFE 456
                E + +    + +KL    L   K++L+   +  K+++I +S E      +    +E
Sbjct: 1558 SLL-ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYE 1616

Query: 457  GLDSSTAS-SMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQ 515
             L  S  + S E E ++H  E  R+E Q+L G++    +  ++ E +Q+ EAE   E+++
Sbjct: 1617 ILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE-KQLQEAEQEMEEMK 1675

Query: 516  DLHDQIAGQKASK-QELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQL 574
            +   + A  K  K  ELE E +RL+ E H   +       TL S      EE+++++  +
Sbjct: 1676 EKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVK--M 1733

Query: 575  TNKTLSNSSQS----------ELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQ 624
              +TLS   QS          E+++  HQ+ E  + KQ  LE+     N    Q    E+
Sbjct: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQI-EGNVSKQANLEATEKHDN----QTNVTEE 1788

Query: 625  QMNSASGSSSNGSSINMS 642
               S  G +    S++MS
Sbjct: 1789 GTQSIPGETEEQDSLSMS 1806



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 109/501 (21%), Positives = 199/501 (39%), Gaps = 113/501 (22%)

Query: 220  KSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRM 279
            K  E+       Q ++ ++Q+        L+ +K  QEEL+ AR  +E          R+
Sbjct: 1467 KPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIE----------RL 1516

Query: 280  TRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEG 339
            T+ L      ++     KD+ L  L +  +E D+L++    +L   QS     +    E 
Sbjct: 1517 TKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQS-----LSSSCES 1571

Query: 340  NSLQNQALQTFQERLHEADATLKRE--------QESYKQMQSEFAARLNKVEM---ERQN 388
              L  + L   +E+L +   +LK          QE +K++Q E+   L   E    E + 
Sbjct: 1572 LKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAER 1631

Query: 389  LAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINS 448
            +   +    ++  +   ++   +   K  +  L+ ++QE+ + K+K  +  +SK++ I  
Sbjct: 1632 IQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILE 1691

Query: 449  LKEGSG----------------FEGLDSSTASSME-LEELRHEKEMQREEIQKLMGQIHQ 491
            L+E +                  E L SS AS  E LE ++ E E   ++ Q LM +   
Sbjct: 1692 LEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDS 1751

Query: 492  LRSELQDMEAQ-QVNEAESAREQLQDLHDQ-----------IAGQKASKQELET------ 533
            L  E+QD++ Q + N ++ A  +  + HD            I G+   +  L        
Sbjct: 1752 LSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTC 1811

Query: 534  -----------------------------ELERLKQEFHYIEED----------LYRTKN 554
                                         ++++LK+    +EE+          L   KN
Sbjct: 1812 SESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKN 1871

Query: 555  TLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNS 614
            TL S+I  +D E++ L+ ++T   L N    E  +R+ +L ET  +++  LE        
Sbjct: 1872 TLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLE-------- 1923

Query: 615  LVFQLERLEQQMNSASGSSSN 635
                 ERL  Q+   +GS  N
Sbjct: 1924 -----ERLMNQLAELNGSIGN 1939



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 93/461 (20%), Positives = 205/461 (44%), Gaps = 61/461 (13%)

Query: 179  QTHEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEV 238
            +  +A   ++   E  +   KEN+   A           D     +S+L+ +   +  + 
Sbjct: 2430 ENKKAVDKTNQLMETLKTIKKENIQQKAQL---------DSFVKSMSSLQNDRDRIVGDY 2480

Query: 239  QSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKD 298
            Q L +   S++    +  +E            A+++K     RGLR+ +DDL    A  D
Sbjct: 2481 QQLEERHLSIILEKDQLIQEAA----------AENNKLKEEIRGLRSHMDDLNSENAKLD 2530

Query: 299  SQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEAD 358
            ++L   +   ++ +Q+++ +        S++ ++++ Q +    QN+ L+    +L E  
Sbjct: 2531 AELIQYR---EDLNQVITIK-------DSQQKQLLEVQLQ----QNKELENKYAKLEE-- 2574

Query: 359  ATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQ--VKL 416
              LK  +E+ + ++  F    N ++ E+Q+L++ I   +   S   ++V  LQ++  + L
Sbjct: 2575 -KLKESEEANEDLRRSF----NALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGL 2629

Query: 417  YKLNLESSKQEL----IDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELR 472
            Y   L+  ++E+      +     RI + +E+L+   KE +   G +       EL+ L 
Sbjct: 2630 YHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVG-EIEDKLKKELKHLH 2688

Query: 473  HEKEMQREEIQKLMGQIHQLRSELQDMEAQQV---NEAESAREQLQDLHDQIAGQKASKQ 529
            H+  + R E +    ++ +L  +L +ME + +    E +    Q+Q     ++  + S+ 
Sbjct: 2689 HDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRD 2748

Query: 530  ELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTL--SNSSQSEL 587
                EL+ LK+++    ++L + K   +  + +R+      R+ L ++T    NS++   
Sbjct: 2749 HANEELDELKRKYDASLKELAQLK---EQGLLNRE------RDALLSETAFSMNSTEENS 2799

Query: 588  ENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
             + L +L + L+ K   L  LS++      Q++   + M S
Sbjct: 2800 LSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMAS 2840



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 100/523 (19%), Positives = 229/523 (43%), Gaps = 46/523 (8%)

Query: 143  EKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEESSKENV 202
            EK +      S+TS   S+N +   +K+ +++  G ++  A  +    H+ + E  K  +
Sbjct: 636  EKEQASTEHQSRTSEEISLNDAGVELKSTKQD--GDKSLSAVPDIGQCHQDELERLKSQI 693

Query: 203  SS---NAACPDHTPTPNDDGKSHELSNLRLENQLLR----------NEVQSLNQEMASLL 249
                 N          N D K+ E+SNL   NQL+           +   +L++E   LL
Sbjct: 694  LELELNFHKAQEIYEKNLDEKAKEISNL---NQLIEEFKKNADNNSSAFTALSEERDQLL 750

Query: 250  QRSKETQEELNKARARVEKWNADHSKSDRMTRG-----------LRAQVDDLTEAVAAKD 298
             + KE    + + RA+V++   + ++++R  R            L  Q+  L+    +KD
Sbjct: 751  SQVKELSM-VTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKD 809

Query: 299  SQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEAD 358
             ++ VL+  L +     S ++  + +LQS+      +  EG     + ++    ++ E  
Sbjct: 810  VKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGA----ERVRHISSKVEELS 865

Query: 359  ATLKREQESYKQMQSEFAARLNKVEMERQNLAEAIT-LAERKYSDEKKRVDELQQQVKLY 417
              L +++    +M      +   VE  +Q + E    + E  +S  +K V   +++  L 
Sbjct: 866  QALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSL- 924

Query: 418  KLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEM 477
             + +++ K++L +   +A    + + +  N +  G      + S A  +  EEL+HE ++
Sbjct: 925  GVEIKTLKEQL-NLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDL 983

Query: 478  QREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQD-LHDQIAGQKASKQELETELE 536
             ++E ++   ++       +++  Q+V+  E     L+D    +I   +  + E+E + E
Sbjct: 984  LKKENEQRKRKLQAALINRKEL-LQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKE 1042

Query: 537  RLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTE 596
              +     +       +  L+  I +++ E+Q +R  L  K    +++ + +  + Q+ +
Sbjct: 1043 NKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKL---AAEEQFQALVKQMNQ 1099

Query: 597  TLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSI 639
            TL  K   ++ L  E    + + + + Q++ +++  +S+G S+
Sbjct: 1100 TLQDKTNQIDLLQAE----ISENQAIIQKLITSNTDASDGDSV 1138



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 90/469 (19%), Positives = 200/469 (42%), Gaps = 49/469 (10%)

Query: 227 LRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQ 286
           L+ +++ L+ E ++ + ++  L   +K     LNK    +E+  A              Q
Sbjct: 75  LQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKY---IEEMKAQGGTVLPTEPQSEEQ 131

Query: 287 VDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQA 346
           +    ++   ++ ++  +K +LQE ++L+ST    L   Q+E+      + E   +  Q 
Sbjct: 132 LSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQ 191

Query: 347 LQTFQERLHEADATLKREQ--ESYKQMQSEFAARL-NKVEMERQNLAEAITLAERKYSDE 403
           LQ  +E +    A L + Q  ++ +Q+  E  AR   +V +    L + +T A+ +    
Sbjct: 192 LQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVE---- 247

Query: 404 KKRVDELQQQVKLYKLNLESSKQELI-----------------DYKQKATRILQSKEKLI 446
                E+QQ++++ +  LE  ++ L+                    Q  ++ LQ  E   
Sbjct: 248 ----TEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEH 303

Query: 447 NSLKEGSGFEGLDSS-TASSMELEELRHEKEMQ--REEIQKLMGQIHQLRSELQDMEAQQ 503
           N+L+     E  +S      MELE    +      +EE+  L+ Q  Q      ++E++ 
Sbjct: 304 NTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRY 363

Query: 504 VNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEED-------LYRTKNTL 556
               +  + ++++    I   + + QEL++  + LK +   + +D         +T   L
Sbjct: 364 SALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQL 423

Query: 557 QSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQK-----QTMLESLSTE 611
           + +++ + +EI +  N+L  +    +SQ+   +  ++ T+ + ++     Q  +  L  E
Sbjct: 424 EDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENE 483

Query: 612 KNSLV---FQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPV 657
           K +L+    +LE L+ +    S   +   + N +G  + E + +  V +
Sbjct: 484 KGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDI 532



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 89/450 (19%), Positives = 203/450 (45%), Gaps = 39/450 (8%)

Query: 185  SNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQE 244
            SN+D+S        KE V  +  C   +     + +   L+ L  E + L+ ++Q     
Sbjct: 1128 SNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILA-LEKEKEQLQKKLQEALTS 1186

Query: 245  MASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVL 304
              ++L++++E +  L   R  +++   D+++       L+ Q D+ ++       QL  L
Sbjct: 1187 RKAILKKAQEKERHL---REELKQQKDDYNR-------LQEQFDEQSKENENIGDQLRQL 1236

Query: 305  KVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERL------HEAD 358
            +++++E+       T+  E+  S     +++     + Q+      +  L      H  D
Sbjct: 1237 QIQVRESIDGKLPSTDQQESCSSTPG--LEEPLFKATEQHHTQPVLESNLCPDWPSHSED 1294

Query: 359  ATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYK 418
            A+  +   S  Q++    A+L ++E E+  L   ++    + + + + V +LQ+Q+    
Sbjct: 1295 ASALQGGTSVAQIK----AQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQG 1350

Query: 419  LNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQ 478
            L +ES K    + +  A  +   ++KL +S  + +G E L        EL++L  +KE  
Sbjct: 1351 LEIESLKTVSHEAEVHAESL---QQKLESSQLQIAGLEHLRELQPKLDELQKLISKKE-- 1405

Query: 479  REEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERL 538
             E++  L GQ+ +  + L  ++ + + + +  +     L  Q        ++L+ EL  +
Sbjct: 1406 -EDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEM 1464

Query: 539  KQEFHYIEED---LYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLT 595
            KQ+   I E+     + +  LQ+ +  R E +++      NK+L     S     + +LT
Sbjct: 1465 KQKPEEIGEESRAKQQIQRKLQAALISRKEALKE------NKSL-QEELSLARGTIERLT 1517

Query: 596  ETLIQKQTMLESLSTEKNSLVFQLERLEQQ 625
            ++L   ++ + + + EK++++ +L  L+++
Sbjct: 1518 KSLADVESQVSAQNKEKDTVLGRLALLQEE 1547



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 78/409 (19%), Positives = 167/409 (40%), Gaps = 29/409 (7%)

Query: 230  ENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKW-----NADHSKSD--RMTRG 282
            E Q L+  + S   ++A+  +     Q++ ++     +KW     +A  SK +  R+   
Sbjct: 2172 EVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKED 2231

Query: 283  LRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSL 342
              + + D    ++    +L +   RL+   Q+  ++ +    LQ +    +Q +++    
Sbjct: 2232 NCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLS 2291

Query: 343  QNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSD 402
            Q +  +          A L+ E +S K   ++ +  L K + ++ NL   I   E    +
Sbjct: 2292 QLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQN 2351

Query: 403  EKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSST 462
             K   ++L+  ++  +       +E+   +QK   +L  KE+ I                
Sbjct: 2352 SKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAI---------------- 2395

Query: 463  ASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIA 522
               + + ELR + + + +E++ L+ Q  +    L++   + V++     E L+ +  +  
Sbjct: 2396 --QVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENI 2453

Query: 523  GQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKL---RNQLTNKTL 579
             QKA        +  L+ +   I  D  + +    S I ++D+ IQ+     N+L  +  
Sbjct: 2454 QQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIR 2513

Query: 580  S-NSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMN 627
               S   +L +   +L   LIQ +  L  + T K+S   QL  ++ Q N
Sbjct: 2514 GLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQN 2562



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 67/296 (22%), Positives = 135/296 (45%), Gaps = 40/296 (13%)

Query: 336 QSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITL 395
           Q       N   +  QERL  A+           Q+  E    + + +++ Q   EA+  
Sbjct: 36  QESDMEFNNTTQEDVQERLAYAE-----------QLVVELKDIIRQKDVQLQQKDEALQ- 83

Query: 396 AERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRIL----QSKEKLINSLKE 451
            ERK +D K +  +L  + KL  LN     + + + K +   +L    QS+E+L    K 
Sbjct: 84  EERKAADNKIKKLKLHAKAKLTSLN-----KYIEEMKAQGGTVLPTEPQSEEQLSKHDK- 137

Query: 452 GSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAR 511
                   SST   ME+E+++H+ + + E I  L  Q+ Q ++E     + ++ E    +
Sbjct: 138 --------SSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMK 189

Query: 512 EQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNT-LQSRIKDRDEEIQKL 570
           +QLQ+  + I+  +A  Q  +T+ E+  Q+       + R K+   +++++  ++E+ +L
Sbjct: 190 QQLQEKEEFISTLQA--QLSQTQAEQAAQQ-------VVREKDARFETQVRLHEDELLQL 240

Query: 571 RNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQM 626
             Q   +T        L+ +L +  E+L+ +  +++ L  E  +   + + L QQ+
Sbjct: 241 VTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQL 296



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 76/395 (19%), Positives = 169/395 (42%), Gaps = 69/395 (17%)

Query: 230  ENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVE---KWNADHSKSDRMTRGLRA- 285
            EN+ L  ++QS  + M+SL        EEL++ + + +   K  A   +   + R   A 
Sbjct: 2725 ENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDAL 2784

Query: 286  -----------------QVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSE 328
                              ++ L + + +KD QL  L  +L+++   + + ++A+ +LQ+E
Sbjct: 2785 LSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE 2844

Query: 329  KSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQN 388
            +  +  +  +    +       ++R     +T   E +S K+  S      +++  E +N
Sbjct: 2845 RDHLWNELEKFRKSEEG-----KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKN 2899

Query: 389  LAEAITLAERKYSD---EKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKL 445
            L +      ++ ++    K ++ E Q + K +++  E  +QE + ++ +  ++   K   
Sbjct: 2900 LQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEK--- 2956

Query: 446  INSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVN 505
                              SS E+    HE+ M+ + +  +  +  QL S LQ++    + 
Sbjct: 2957 ------------------SSWEI----HERRMKEQYLMAISDKDQQL-SHLQNL----IR 2989

Query: 506  EAESAREQLQDLHDQIAGQKA--------SKQELETELERLKQEFHYIEEDLYRTKNTLQ 557
            E  S+  Q Q L  Q   Q +          Q L  E E L+ + +   +++++ +  +Q
Sbjct: 2990 ELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQ 3049

Query: 558  SRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLH 592
             ++     ++ + +N L+ + L ++SQS  EN+ H
Sbjct: 3050 -QLNSNFSQLLEEKNTLSIQ-LCDTSQSLRENQQH 3082



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 96/446 (21%), Positives = 179/446 (40%), Gaps = 96/446 (21%)

Query: 220  KSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRM 279
            K  +L +L  + +   N+VQS ++ MASL         EL K R           KS+  
Sbjct: 2813 KDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR-----------KSEEG 2861

Query: 280  TRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEG 339
             +   AQ        +   +++  LK              +A+ +LQ+++ R+++   E 
Sbjct: 2862 KQRSAAQ-------PSTSPAEVQSLK--------------KAMSSLQNDRDRLLK---EL 2897

Query: 340  NSLQNQALQTFQE--RLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAE 397
             +LQ Q LQ  QE   LH   A L+  Q+  K  Q      + + E+ ++NL+    L +
Sbjct: 2898 KNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQ------IMQEELRQENLSWQHELHQ 2951

Query: 398  RKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEG 457
             +   EK   +  ++++K   L   S K + + + Q   R L+S       LK     + 
Sbjct: 2952 LRM--EKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQA 3009

Query: 458  LDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEA--------------QQ 503
               ++AS    + L +E E+ R ++   + +IHQ    +Q + +              Q 
Sbjct: 3010 SPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQL 3069

Query: 504  VNEAESAREQLQ---DLHDQIAGQKASKQELET-------------------------EL 535
             + ++S RE  Q   DL +  A  +   QEL+                          EL
Sbjct: 3070 CDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEEL 3129

Query: 536  ERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQL- 594
               +Q F   ++ L  T+  +    K  +EE    R+Q   +  + ++ S  E ++ +L 
Sbjct: 3130 REPQQSFSEAQQQLCNTRQEVNELRKLLEEE----RDQ---RVAAENALSVAEEQIRRLE 3182

Query: 595  -TETLIQKQTMLESLSTEKNSLVFQL 619
             +E    +  ++ S  T++ +L+  L
Sbjct: 3183 HSEWDSSRTPIIGSCGTQEQALLIDL 3208



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 93/438 (21%), Positives = 179/438 (40%), Gaps = 39/438 (8%)

Query: 188 DSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMAS 247
           +  H+ + E    ++ S         +  D  K      L+ +N+      Q++ Q    
Sbjct: 367 EQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQ 426

Query: 248 LLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVR 307
           L Q+SKE  + LN+   +  +  +  S  D    G +A  +   E +A+   ++  L+  
Sbjct: 427 LQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTE---ENIASLQKRVVELE-- 481

Query: 308 LQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQES 367
             E   LL +  E LE L++E  ++        S Q   L+  Q R  EAD    RE   
Sbjct: 482 -NEKGALLLSSIE-LEELKAENEKL--------SSQITLLEA-QNRTGEAD----REVSE 526

Query: 368 YKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQE 427
              +        +  E  +  L    +   ++ S     + E Q+++   KL L+  + E
Sbjct: 527 ISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAE 586

Query: 428 LIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMG 487
             D++     +L  KE     +K+  G EG+ +     + LE+   +  +   E   L  
Sbjct: 587 EADHE-----VLDQKE-----MKQMEG-EGI-APIKMKVFLEDTGQDFPLMPNEESSLPA 634

Query: 488 -QIHQLRSELQDMEAQQVNEAESA---REQLQDLHDQIAGQKASKQELETELERLKQEFH 543
            +  Q  +E Q   +++++  ++    +   QD    ++      Q  + ELERLK +  
Sbjct: 635 VEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQIL 694

Query: 544 YIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNS-SQSELENRLHQLTETLIQKQ 602
            +E + ++ +   +  + ++ +EI  L NQL  +   N+ + S     L +  + L+ + 
Sbjct: 695 ELELNFHKAQEIYEKNLDEKAKEISNL-NQLIEEFKKNADNNSSAFTALSEERDQLLSQV 753

Query: 603 TMLESLSTEKNSLVFQLE 620
             L S+ TE  + V QLE
Sbjct: 754 KEL-SMVTELRAQVKQLE 770


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 93/456 (20%), Positives = 186/456 (40%), Gaps = 48/456 (10%)

Query: 221  SHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNA--DHSKSDR 278
            S E  +L+ +  +   ++    + +A+  + SK  Q  L K    V K     D    D+
Sbjct: 1786 SKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDK 1845

Query: 279  MT-----RGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIM 333
            ++       ++ Q+ +  EAV +   +LA ++  L  A Q L   T+  + L SE++R+ 
Sbjct: 1846 LSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQ 1905

Query: 334  QDQSEG----------NSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVE 383
            +D SE              + Q LQ  Q  + E    L +++  ++++Q E  +  +K+E
Sbjct: 1906 KDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLE 1965

Query: 384  MERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKE 443
              +  L E     E++ +D+K ++D++  +V         + +E +   Q+  R  +S E
Sbjct: 1966 TSKVTLKEQQHQLEKELTDQKSKLDQVLSKV--------LAAEERVRTLQEEERWCESLE 2017

Query: 444  KLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQ 503
            K ++  K     E        S EL  L+ E +  R +   L    +Q  +E +  E Q 
Sbjct: 2018 KTLSQTKRQLS-EREQQLVEKSGELLALQKEADSMRADFSLLR---NQFLTERKKAEKQV 2073

Query: 504  VNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDR 563
             +  E+ + Q   L   +  QK     ++ E+  ++     + +D +     L   +   
Sbjct: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIE----LVAQDNHERARRLMKELNQM 2129

Query: 564  DEEIQKLRNQLTN---------------KTLSNSSQSELENRLHQLTETLIQKQTMLESL 608
              E  +L+ Q+ N               +TL +  + E+   L  L + L +    LE++
Sbjct: 2130 QYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAI 2189

Query: 609  STEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGI 644
                 +L  +LE L++ +            +N S +
Sbjct: 2190 LERNENLEGELESLKENLPFTMNEGPFEEKLNFSQV 2225



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 90/447 (20%), Positives = 194/447 (43%), Gaps = 63/447 (14%)

Query: 220  KSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRM 279
            K  E   +R   +    E++ L+  +  LLQ  K  + E+ +    V+K        D  
Sbjct: 1338 KKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGN 1397

Query: 280  TRGLRAQVD---------DLTEAVAAKDSQLAVLKVRLQEADQLLSTRTE---------- 320
               L  +++         D+ + +   +  L   +  L+EAD+LL+              
Sbjct: 1398 VESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTK 1457

Query: 321  -ALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLK------REQESYKQMQS 373
             A+E     K  ++Q +S+   L+ +A +T    L +AD  L+      ++ E +K  Q 
Sbjct: 1458 NAVEKFTDAKRSLLQTESDAEELERRAQET-AVNLVKADQQLRSLQADAKDLEQHKIKQE 1516

Query: 374  EFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQ 433
            E    +NK+   + +  + ++  + K ++E   + +LQ+ +++ + N +   Q L    +
Sbjct: 1517 EILKEINKIVAAKDSDFQCLSKKKEKLTEE---LQKLQKDIEMAERNEDHHLQVL----K 1569

Query: 434  KATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLR 493
            ++  +LQ+K   +  LK           T+   E+  L  +   ++EE+  L G + Q +
Sbjct: 1570 ESEVLLQAKRAELEKLKS--------QVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAK 1621

Query: 494  SELQDMEAQQVNEAESARE-----QLQDLHDQIAGQKASKQELETELERLKQEFHYIEED 548
            ++LQ  EA ++ E E   +     +++ L ++++ QK    EL  ++   K +   I+++
Sbjct: 1622 ADLQ--EALRLGETEVTEKCNHIREVKSLLEELSFQKG---ELNVQISERKTQLTLIKQE 1676

Query: 549  LYRTKNTLQSRIKDRDEEIQKLRN-----QLTNKTLS------NSSQSELENRLHQLTET 597
            + + +  LQ  ++   +   +L+N     QL N  L       +   SELE     + E 
Sbjct: 1677 IEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEE 1736

Query: 598  LIQKQTMLESLSTEKNSLVFQLERLEQ 624
             ++ + + +    +K  + +Q + LE+
Sbjct: 1737 KLELENLQQISQQQKGEIEWQKQLLER 1763



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 100/474 (21%), Positives = 199/474 (41%), Gaps = 83/474 (17%)

Query: 228  RLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRM-------- 279
            R E + L+++V S  QEMA L ++    +EEL+  +  + +  AD  ++ R+        
Sbjct: 1579 RAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEK 1638

Query: 280  ----------TRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEK 329
                         L  Q  +L   ++ + +QL ++K  +++ ++ L      +   ++E 
Sbjct: 1639 CNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTEL 1698

Query: 330  SRIMQD-QSEGNSLQNQALQTFQERLHEADAT---------------------------- 360
              I+   Q E + LQ   LQ   +R+ E + T                            
Sbjct: 1699 KNILDMLQLENHELQGLKLQ-HDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQ 1757

Query: 361  ---LKREQESYKQMQSEFAARLNKVEM---ERQNLAEAITLAERKYSDEKKRVDELQQQV 414
               L+R++   ++M +E  A  + VE    E+++L E   + E+K +  K+ +   ++  
Sbjct: 1758 KQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENS 1817

Query: 415  KLYKLNLESSKQELIDYKQKATRI-----------------LQSKEKLINSLKEGSGFEG 457
            K+ + NLE  +  +   +Q+  ++                 LQ K + +NSL+E      
Sbjct: 1818 KMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQ 1877

Query: 458  LDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDL 517
               + A    L   +H+  +  E+  +L   I +  +  +D +     E E+ ++QLQ L
Sbjct: 1878 DHLNLAKQDLLHTTKHQDVLLSEQ-TRLQKDISEWANRFEDCQ----KEEETKQQQLQVL 1932

Query: 518  HDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNK 577
             ++I   K    + E   +RL++E    E  L  +K TL+ +    ++E+   +++L ++
Sbjct: 1933 QNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKL-DQ 1991

Query: 578  TLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASG 631
             LS    +E      +   TL +++   ESL    +    QL   EQQ+   SG
Sbjct: 1992 VLSKVLAAE------ERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSG 2039



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 90/437 (20%), Positives = 185/437 (42%), Gaps = 62/437 (14%)

Query: 223  ELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRG 282
            +  N+R E   L + +Q  ++  ASL Q    TQ +L+   A +E   A  +  D     
Sbjct: 669  DAENMRKELAELESALQEQHEVNASLQQ----TQGDLSAYEAELE---ARLNLRDAEANQ 721

Query: 283  LRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRI---MQDQSEG 339
            L+ +++ +T     + S L     + ++A +    + +  E  + E S +   ++   + 
Sbjct: 722  LKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDD 781

Query: 340  NSLQNQALQTFQERL-HEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAI----- 393
            N+L  Q L+ FQ  L H  D  ++ E+ + +  +     +L   EM   + ++ +     
Sbjct: 782  NNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLA 841

Query: 394  --------TLAERKYSDEKKRVDE--LQQQVKLYKLNLESSKQEL-------------ID 430
                     LA  K+  ++ +V E  LQ+++ L +  L + ++E               D
Sbjct: 842  DLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFD 901

Query: 431  YKQKATRILQSKEKL------INSLKEGSGFEGLDSSTASS------MELEELRHEKEMQ 478
             +Q   RI Q + ++      + S++E  G   L    A         +L EL  +K+++
Sbjct: 902  KRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLE 961

Query: 479  ----REEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETE 534
                +E++  L  ++ +L+  +   +     E   A++QL+ LH  +      + E   E
Sbjct: 962  DAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQE 1021

Query: 535  LERLKQEFHYIEEDLYRTK---NTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRL 591
             ER  ++      DL R +     LQ+ ++ + E+ +    +    T +NS   E+E   
Sbjct: 1022 AERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIE--- 1078

Query: 592  HQLTETLIQKQTMLESL 608
             +L ET+ +++T +  L
Sbjct: 1079 -KLNETMERQRTEIARL 1094



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 86/466 (18%), Positives = 202/466 (43%), Gaps = 69/466 (14%)

Query: 219  GKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDR 278
            GK  +L  +  + Q L + +  +   +A   +  K+ +E+L + +          + ++ 
Sbjct: 559  GKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQI---------AANEA 609

Query: 279  MTRGLRAQVDDLTEAVA-----AKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIM 333
            + + L   +  L E +      A  +Q    K+R  E + LL   TE  +  + ++  I+
Sbjct: 610  LKKDLEGVISGLQEYLGTIKGQATQAQNECRKLR-DEKETLLQRLTEVEQ--ERDQLEIV 666

Query: 334  QDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLN------------- 380
               +E    +   L++  +  HE +A+L++ Q      ++E  ARLN             
Sbjct: 667  AMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL 726

Query: 381  --------------KVEMERQNLAEAITLAERKYSDEKKRVD-ELQQQVKLYKLNLESSK 425
                          + E+E++  A    L + ++S+EK++ + EL  ++K  + +    K
Sbjct: 727  EKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLK 786

Query: 426  QELIDYKQKATRILQS----------KEKLINSLKEGSGFEGLDS-STASSMELEELRHE 474
            Q+L D++     ++             ++L   LK G+G   + S S      L +L+ +
Sbjct: 787  QQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQ 846

Query: 475  --KEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQI--AGQKASKQE 530
              + + R + ++   Q+ +   +LQ+  A Q  +  + +E+ +   ++   A     K++
Sbjct: 847  FSEILARSKWERDEAQVRE--RKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQ 904

Query: 531  LETELERLKQEFHYIEEDLYRTKNTLQS----RIKDRDEEIQKLRNQLTNKTLSNSSQSE 586
             E  +++++ E HY++E+L ++   +Q     ++++ DEE +++  QL  + L    + E
Sbjct: 905  HEARIQQMENEIHYLQENL-KSMEEIQGLTDLQLQEADEEKERILAQL--RELEKKKKLE 961

Query: 587  LENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGS 632
                  Q+     + + + ++++T       +L   + Q+ S  G+
Sbjct: 962  DAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGT 1007



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 110/536 (20%), Positives = 212/536 (39%), Gaps = 58/536 (10%)

Query: 107 SSHFVRRKKSEPDDELLFDFLNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVT 166
           S+  V+ KK EPD++L  D +N     P       KEK K    Q+  +     +  +  
Sbjct: 407 SAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEK-KISAAQTRLSELHDEIEKAEQ 465

Query: 167 TIKTIEENSFGSQTHEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSN 226
            I    E     Q  EA      S  G++   K+                  G+   ++ 
Sbjct: 466 QILRATEEF--KQLEEAIQLKKISEAGKDLLYKQL----------------SGRLQLVNK 507

Query: 227 LRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQ 286
           LR E   L  +++   QE+A   +  K+ Q  ++   ++  K    HS       G   Q
Sbjct: 508 LRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPK----HSHMKAQKSGKEQQ 563

Query: 287 VDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQA 346
           +D + +     +S+L          D++LS   +  E ++  + ++ + Q   N    + 
Sbjct: 564 LDIMNKQYQQLESRL----------DEILSRIAKETEEIKDLEEQLTEGQIAANEALKKD 613

Query: 347 LQTFQERLHEADATLK----REQESYKQMQSE---FAARLNKVEMERQNLAEAITLAERK 399
           L+     L E   T+K    + Q   ++++ E      RL +VE ER  L E + +    
Sbjct: 614 LEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQL-EIVAMDAEN 672

Query: 400 YSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLD 459
              E   ++   Q+      +L+ ++ +L  Y+ +    L  ++   N LKE    E   
Sbjct: 673 MRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKE----ELEK 728

Query: 460 SSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQD--- 516
            +  + +E   L+ E E +R+ ++  +G     +++  + + Q+ +E  +  + LQD   
Sbjct: 729 VTRLTQLEQSALQAELEKERQALKNALG-----KAQFSEEKEQENSELHAKLKHLQDDNN 783

Query: 517 -LHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTK-NTLQSRIKDRDEEIQKLRNQL 574
            L  Q+   +     +   L R ++    ++E   + K  T +  I    + + K    L
Sbjct: 784 LLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADL 843

Query: 575 TNKTLSNSSQSELENRLHQLTETLIQKQTML--ESLSTEKNSLVFQLER-LEQQMN 627
             +     ++S+ E    Q+ E  +Q++  L  E L+T +       ER LE +MN
Sbjct: 844 QKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMN 899



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 71/327 (21%), Positives = 140/327 (42%), Gaps = 60/327 (18%)

Query: 352 ERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQ 411
           E L     T +  QE++++   E   RL +   ++    E +   + ++ +E K  D+L 
Sbjct: 248 ESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLN 307

Query: 412 QQVK----LYKLNLE------SSKQELIDYKQ-KATRILQSKEKLINSL---KEGSGFEG 457
           + +K    L K + E      ++K EL+  K  + TR  Q + +L   L   K  + FE 
Sbjct: 308 KSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEP 367

Query: 458 L----------DSSTASSMELEELRHEKEM-----------QREEIQKLMGQIHQLRSEL 496
           L          D +   S  + + R+++ M           Q  +I+K M    QLR++ 
Sbjct: 368 LNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKK-MEPDEQLRNDH 426

Query: 497 QDMEAQ-----QVNEAE----SAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEE 547
            ++        Q+ + E    +A+ +L +LHD+I       ++ E ++ R  +EF  +EE
Sbjct: 427 MNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEI-------EKAEQQILRATEEFKQLEE 479

Query: 548 DLY------RTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQ-SELENRLHQLTETLIQ 600
            +         K+ L  ++  R + + KLR +  +  L    Q  E+  +  ++ +  I 
Sbjct: 480 AIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIA 539

Query: 601 KQTMLESLSTEKNSLVFQLERLEQQMN 627
             + L+S   + + +  Q    EQQ++
Sbjct: 540 IDS-LDSKDPKHSHMKAQKSGKEQQLD 565



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 33/146 (22%), Positives = 69/146 (47%), Gaps = 9/146 (6%)

Query: 486  MGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYI 545
            MG +H    E  ++E  +V+  E   + L+    +    +ASK++ E E+E    E H+ 
Sbjct: 1308 MGVLHCNVPEHHNLE-NEVSRLEDIMQHLKSKKREERWMRASKRQSEKEME----ELHHN 1362

Query: 546  EEDLYRTKNTLQSRIKDRDEEIQKLRNQ---LTNKTLSNSSQSELENRLHQLTETLIQKQ 602
             +DL + K +L+  +++    +QK + Q   +     S  ++ E+E  L    E ++ + 
Sbjct: 1363 IDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKH-HEDIVDEI 1421

Query: 603  TMLESLSTEKNSLVFQLERLEQQMNS 628
              +E    ++ S + + +RL  +  S
Sbjct: 1422 ECIEKTLLKRRSELREADRLLAEAES 1447



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 33/173 (19%), Positives = 77/173 (44%), Gaps = 18/173 (10%)

Query: 471  LRHEKEMQREEIQKLMGQIHQLRSELQDMEAQ--QVNEAESAREQLQDLHDQIAGQKASK 528
            +R  K    +E+++L   I  L  E + +E +  +++     R+Q +D  D       ++
Sbjct: 1345 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTE 1404

Query: 529  QELETEL---ERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQS 585
             E+E  L   E +  E   IE+ L + +    S +++ D  + +  ++L+       ++ 
Sbjct: 1405 LEIEKSLKHHEDIVDEIECIEKTLLKRR----SELREADRLLAEAESELS------CTKE 1454

Query: 586  ELENRLHQLTE---TLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSN 635
            + +N + + T+   +L+Q ++  E L          L + +QQ+ S    + +
Sbjct: 1455 KTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKD 1507


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 105/428 (24%), Positives = 206/428 (48%), Gaps = 78/428 (18%)

Query: 222 HELSNLRLENQL--LRNEVQSLNQEMASLLQRSKET--------QEELNKARARVEKWNA 271
           H     +L  QL   +N ++ L Q+   ++  +K          +EE+ + R+R+++   
Sbjct: 337 HMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTT 396

Query: 272 DHSK-SDRMTRGLRAQVDDLTEAVA-AKDSQLAVLKVRLQEADQLLS---TRTEALEALQ 326
              +  ++  +  RA  ++L +A++ A+ ++ A  K++ +  +Q+ +   T  E   +LQ
Sbjct: 397 QGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQ 456

Query: 327 SEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQS---EFAARLNKVE 383
            E SR+ Q+  +     ++      ++LHE +   ++EQE  K++Q+   EF  ++ KV 
Sbjct: 457 QELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELA-RKEQELTKKLQTREREFQEQM-KVA 514

Query: 384 MERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKA----TRIL 439
           +E+   +E + +++ K   E   ++EL+ Q K     L  S+ +L D +Q+A    TRIL
Sbjct: 515 LEKSQ-SEYLKISQEKEQQESLALEELELQKKAI---LTESENKLRDLQQEAETYRTRIL 570

Query: 440 QSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDM 499
           + +  L  SL+E    +      A  +E E+ +H KE+       +M + H  ++EL+ +
Sbjct: 571 ELESSLEKSLQEN---KNQSKDLAVHLEAEKNKHNKEIT------VMVEKH--KTELESL 619

Query: 500 EAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSR 559
           + QQ        E+LQ L          KQ+ +TE+E+L+++    +E L          
Sbjct: 620 KHQQ---DALWTEKLQVL----------KQQYQTEMEKLREKCEQEKETL---------- 656

Query: 560 IKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQL 619
           +KD++   Q    ++  KTL                E L  KQT LESLS+E + ++   
Sbjct: 657 LKDKEIIFQAHIEEMNEKTL----------------EKLDVKQTELESLSSELSEVLKAR 700

Query: 620 ERLEQQMN 627
            +LE++++
Sbjct: 701 HKLEEELS 708



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 95/410 (23%), Positives = 189/410 (46%), Gaps = 34/410 (8%)

Query: 234 LRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEA 293
           L+ E+  + QE+  ++++S E  E++ K +   EK  A   K   +T+ L+ +  +  E 
Sbjct: 455 LQQELSRVKQEVVDVMKKSSE--EQIAKLQKLHEKELA--RKEQELTKKLQTREREFQEQ 510

Query: 294 --VAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIM-QDQSEGNSLQNQALQTF 350
             VA + SQ   LK+  ++  Q     + ALE L+ +K  I+ + +++   LQ +A +T+
Sbjct: 511 MKVALEKSQSEYLKISQEKEQQ----ESLALEELELQKKAILTESENKLRDLQQEA-ETY 565

Query: 351 QERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDEL 410
           + R+ E +++L++  +  K    + A  L   E E+    + IT+   K+  E + +   
Sbjct: 566 RTRILELESSLEKSLQENKNQSKDLAVHL---EAEKNKHNKEITVMVEKHKTELESLKHQ 622

Query: 411 Q-----QQVKLYKLNLESSKQELIDY-KQKATRILQSKEKLINSLKEGSGFEGLDSSTAS 464
           Q     +++++ K   ++  ++L +  +Q+   +L+ KE +  +  E    + L+     
Sbjct: 623 QDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVK 682

Query: 465 SMELEELRHE-------KEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDL 517
             ELE L  E       +    EE+  L  Q  +++ EL+    +Q N  +   + +   
Sbjct: 683 QTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKE 742

Query: 518 HDQI--AGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLT 575
           H+      +KA K ++      LK+   +++E     +N L++ IK  + E+Q+   +L 
Sbjct: 743 HEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVEN-LEADIKRSEGELQQASAKL- 800

Query: 576 NKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQ 625
              +  S QS    +     E L Q Q  L  L TE+  L  Q+  +E Q
Sbjct: 801 --DVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ 848



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 92/451 (20%), Positives = 203/451 (45%), Gaps = 57/451 (12%)

Query: 220  KSHELSNLRLE-------NQL---LRNEVQSLNQEMA---SLLQRSKETQEELNKARARV 266
            K HE+S  R E       NQL   L+   + L +  A   +L    K ++ EL +A A++
Sbjct: 741  KEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKL 800

Query: 267  EKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQ 326
            + + +  S +   T+    Q+  L + +   +++  +L  ++ E +         L+A +
Sbjct: 801  DVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHK 860

Query: 327  SEKSRIMQDQSEGNSLQNQAL----QTFQERLHEADATLKREQESYKQMQSEFAARLNKV 382
             +   +MQ   + NS   Q +    Q ++ +L + +    +EQE  KQ+  E    + ++
Sbjct: 861  IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGN----KEQEQTKQILVEKENMILQM 916

Query: 383  EMERQNLAEAITLA---------------ERKYSDEKKRVDELQQQVKLYKLNLESSKQE 427
               ++   E +T                 E K+ +++K++++++Q+ K  +   E+ K++
Sbjct: 917  REGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQ---ETLKKK 973

Query: 428  LIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMG 487
            L+D + K  + L++    ++  ++    + L+ + A+S  + +     E  ++E  + + 
Sbjct: 974  LLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLT 1033

Query: 488  QIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQE---FHY 544
            ++H  R EL D+ +    +     E+LQ++H+         QE E E+  LKQ+   F  
Sbjct: 1034 EVH--RRELNDVISIWEKKLNQQAEELQEIHE------IQLQEKEQEVAELKQKILLFGC 1085

Query: 545  IEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETL------ 598
             +E++ +    L+     +D  + +L+ QL  K+   +S ++ E +L    E L      
Sbjct: 1086 EKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNK 1145

Query: 599  -IQKQTMLESLSTEKNSLVFQLERLEQQMNS 628
             +++ T L+    E   L  + +R   ++ S
Sbjct: 1146 SLKENTFLQEQLVELKMLAEEDKRKVSELTS 1176



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 122/571 (21%), Positives = 239/571 (41%), Gaps = 95/571 (16%)

Query: 124  FDFLNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEA 183
            FD L    ++   ++E ++   +T +   SQT+ +  +   +T  KTIE  S        
Sbjct: 1495 FDCLKGEMEDDKSKMEKKESNLETEL--KSQTARIMELEDHITQ-KTIEIESLNEVLKNY 1551

Query: 184  ASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQL--LRNEVQSL 241
                D  H       KE V       +     ++  K  E   L LENQ+  ++ E+++ 
Sbjct: 1552 NQQKDIEH-------KELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETK 1604

Query: 242  NQEMASLLQRSKETQEELNKARARVEKWNAD---------HSKSDRMTRGLRAQVDDLTE 292
             +E+  +    K  +EEL     R+E  +A            K   + + L +Q+++  E
Sbjct: 1605 KKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEE 1664

Query: 293  AVA-AKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIM------------QDQSEG 339
                  +S L+ L  +LQE ++ +    E L++++S +S  +             +Q E 
Sbjct: 1665 QYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEA 1724

Query: 340  NSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNK-VEMERQNLAEAITL--A 396
            +S Q    +T++E++      L  +++  +++  E    ++   EM  Q     I L  A
Sbjct: 1725 DS-QGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHA 1783

Query: 397  ERKYSDEKKRVDELQQQV----KLYKL------------NLESSKQELIDYKQKATRILQ 440
            E K  +++  +  LQ+++    K Y L            N   +KQ L +      + LQ
Sbjct: 1784 EAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQ 1843

Query: 441  SKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDME 500
             KE     L++    + LDS          L  +KE+ R E+++L  +  +L++ LQ M+
Sbjct: 1844 EKELTCQILEQK--IKELDSC---------LVRQKEVHRVEMEELTSKYEKLQA-LQQMD 1891

Query: 501  AQ-------QVNEAESAREQL-------------QDLHDQIAGQKASKQELETELERLKQ 540
             +       + N  E ++  L              DL  ++AG +  KQ+L  E+ RL++
Sbjct: 1892 GRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQK 1951

Query: 541  EFHYIEEDLYRTKNTLQSRI-KDRDEEIQ------KLRNQLTNKTLSNSSQSELENRLHQ 593
            +   + ++  +    L+    ++R+E+I+      +L++  T K L     ++L  +  +
Sbjct: 1952 DLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQE 2011

Query: 594  LTETLIQKQTMLESLSTEKNSLVFQLERLEQ 624
            L  T+  K+T+ ++   E   L    E   Q
Sbjct: 2012 LEMTI--KETINKAQEVEAELLESHQEETNQ 2040



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 79/419 (18%), Positives = 183/419 (43%), Gaps = 16/419 (3%)

Query: 221  SHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMT 280
            +H+L     + + ++ +++SL  E  +L +     Q+  ++  + + +   + S++    
Sbjct: 1296 THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAV 1355

Query: 281  RGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQS----EKSRIMQDQ 336
              ++ ++ +    +++   QL  L V+LQ +  L S +  A+ +L+     EK  ++ DQ
Sbjct: 1356 TLMKEELKEKKVEISSLSKQLTDLNVQLQNSISL-SEKEAAISSLRKQYDEEKCELL-DQ 1413

Query: 337  SEGNSLQNQALQTFQ-ERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITL 395
             +  S +   L   +   L + D    +  E  K+ QS F    N V+     L   + L
Sbjct: 1414 VQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVK----ELQIQLEL 1469

Query: 396  AERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGF 455
              ++  ++ ++++ L++++       +  K E+ D K K  +   + E  + S +     
Sbjct: 1470 KSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS-QTARIM 1528

Query: 456  EGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQ 515
            E  D  T  ++E+E L    +   ++      ++ Q     Q++  ++ N  + A E++ 
Sbjct: 1529 ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588

Query: 516  DLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLT 575
             L +Q+   KA  +  + ELE +       EE+L   ++ L+S    +  E+++   Q  
Sbjct: 1589 TLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKI 1648

Query: 576  NKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSS 634
               +     S++E +  Q  +     ++ L  L+T+      ++  LE+++ S   S S
Sbjct: 1649 -AAIKKQLLSQMEEKEEQYKK---GTESHLSELNTKLQEREREVHILEEKLKSVESSQS 1703



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 96/516 (18%), Positives = 209/516 (40%), Gaps = 68/516 (13%)

Query: 127  LNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEE-NSFG--SQTHEA 183
            LN+  +E    V I +EK K+     S+T  V     +V      EE +S G   +T+E 
Sbjct: 1677 LNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEE 1736

Query: 184  ASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNE-VQSLN 242
              +    +  ++E   + V              +   SH     + + +L++ E  ++  
Sbjct: 1737 KISVLQRNLTEKEKLLQRVGQEK---------EETVSSHFEMRCQYQERLIKLEHAEAKQ 1787

Query: 243  QEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQ------VDDLTEAVAA 296
             E  S++   +E  EE NK  + +    A H + +     ++A+       DD+ + +  
Sbjct: 1788 HEDQSMIGHLQEELEEKNKKYSLIV---AQHVEKEGGKNNIQAKQNLENVFDDVQKTLQE 1844

Query: 297  KDSQLAVLKVRLQEADQLLSTRTEA----LEALQSEKSRIMQ-DQSEGNSLQNQALQTFQ 351
            K+    +L+ +++E D  L  + E     +E L S+  ++    Q +G +   + L+   
Sbjct: 1845 KELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENT 1904

Query: 352  ERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQ 411
            E   ++     +   + +   ++   +L   E E+Q L + I    R   D +    E Q
Sbjct: 1905 EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIV---RLQKDLRMLRKEHQ 1961

Query: 412  QQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEEL 471
            Q++++ K   +  ++E         +I Q +E L                        EL
Sbjct: 1962 QELEILKKEYDQEREE---------KIKQEQEDL------------------------EL 1988

Query: 472  RHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASK-QE 530
            +H   + ++ +++   Q+ Q   EL+    + +N+A+    +L + H +   Q   K  E
Sbjct: 1989 KHNSTL-KQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAE 2047

Query: 531  LETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENR 590
             + +L+R  + +   EE L   +  + ++++D   ++++L+ +   K     +       
Sbjct: 2048 KDDDLKRTAKRY---EEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVT 2104

Query: 591  LHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQM 626
            + +L   L QK T++     ++     Q+  LE ++
Sbjct: 2105 IMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRL 2140



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 116/527 (22%), Positives = 221/527 (41%), Gaps = 59/527 (11%)

Query: 142 KEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEESSKEN 201
           +E G T  F       V SV     +   I+E+ F S + E+   + S    +E  ++ +
Sbjct: 53  RESGDTQSFAQKLQLRVPSVESLFRS--PIKESLFRSSSKESLVRTSS----RESLNRLD 106

Query: 202 VSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNK 261
           + S+ A  D  P  + D ++ +L               SLN+E   L+QR +  +  L+ 
Sbjct: 107 LDSSTASFD--PPSDMDSEAEDLVG----------NSDSLNKEQ--LIQRLRRMERSLSS 152

Query: 262 ARARVEKWNADHS---KSDRMTRGLRAQVDDLT-EAVAAKDSQLAV---LKVRLQEA-DQ 313
            R +  +    +    +  +  +G+ +Q  D +   +A    +L +    K  LQE  D 
Sbjct: 153 YRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDA 212

Query: 314 LLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQ-ESYKQMQ 372
            L  + + +  LQ++ S + Q    G  +    L+   +   +A+   K E  ES  +  
Sbjct: 213 SLEEKDQYISVLQTQVSLLKQRLRNG-PMNVDVLKPLPQLEPQAEVFTKEENPESDGEPV 271

Query: 373 SEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYK 432
            E    +  +E  +Q +     L +R     K+ +   ++Q  L     E+ +++L +  
Sbjct: 272 VEDGTSVKTLETLQQRVKRQENLLKRC----KETIQSHKEQCTLLTSEKEALQEQLDERL 327

Query: 433 QKATRI----LQSKEKLINSLKEGSGF-EGLDSSTASSM-ELEELRHEK-EMQREEIQKL 485
           Q+  +I    +  K KLI  L++     E L+      + E +   HE  EM+ EEI +L
Sbjct: 328 QELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQL 387

Query: 486 MGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETEL-ERLK----- 539
             +I Q+ ++ +++  Q+     +A E+L+         + ++++L+ E+ E++K     
Sbjct: 388 RSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKT 447

Query: 540 --QEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRL------ 591
             +E   ++++L R K  +   +K   EE      +L  K L+   Q EL  +L      
Sbjct: 448 SEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ-ELTKKLQTRERE 506

Query: 592 --HQLTETLIQKQTMLESLSTEKNSL-VFQLERLEQQMNSASGSSSN 635
              Q+   L + Q+    +S EK       LE LE Q  +    S N
Sbjct: 507 FQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESEN 553



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 103/534 (19%), Positives = 207/534 (38%), Gaps = 87/534 (16%)

Query: 129  SSQKEPTGRVEIRKEKGKTPVFQSSQ------TSSVSSVNPSVTTIKTIEENSFGSQTHE 182
            + ++E T ++ + KE     + +  +      T  +S+   S+  +    E  F +Q  +
Sbjct: 896  NKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKK 955

Query: 183  AASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLN 242
                   + E QE   K+ +   A                EL N  LE        Q   
Sbjct: 956  MEKVKQKAKEMQETLKKKLLDQEAKL------------KKELENTALELS------QKEK 997

Query: 243  QEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLA 302
            Q  A +L+ ++     ++ A +R+E    +  +S  +T   R +++D+      K +Q A
Sbjct: 998  QFNAKMLEMAQANSAGISDAVSRLETNQKEQIES--LTEVHRRELNDVISIWEKKLNQQA 1055

Query: 303  -----VLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQS---EGNSLQNQALQTFQERL 354
                 + +++LQE +Q ++   + +     EK  + ++ +   E    Q+  L   QE+L
Sbjct: 1056 EELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL 1115

Query: 355  HEADA---TLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQ 411
             +  A   +L +++   K    +    LNK   E   L E +   +    ++K++V EL 
Sbjct: 1116 KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELT 1175

Query: 412  QQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFE--------------- 456
             ++K      +S K       +K+ + L+ K      L E    +               
Sbjct: 1176 SKLKTTDEEFQSLKSS----HEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAK 1231

Query: 457  -----GLDSSTASSM--ELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVN---E 506
                  + SS  +++   +   +H     +E +      + +L ++L+ +  +Q      
Sbjct: 1232 TNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNIS 1291

Query: 507  AESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEE 566
             + A  QL++  +QI   KA  + L TE E L++E               Q    +++  
Sbjct: 1292 FQQATHQLEEKENQIKSMKADIESLVTEKEALQKE-----------GGNQQQAASEKESC 1340

Query: 567  IQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLE 620
            I +L+ +L          SE  N +  + E L +K+  + SLS +   L  QL+
Sbjct: 1341 ITQLKKEL----------SENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQ 1384


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 95/417 (22%), Positives = 191/417 (45%), Gaps = 43/417 (10%)

Query: 243  QEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLA 302
            +EMA++ +  + T+EEL ++ AR ++         +    L+ QV   TE +   +    
Sbjct: 851  KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAE---- 906

Query: 303  VLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLK 362
                  +  + L+ ++   LEA   E +  ++++ E NS     L   +  L +  ++LK
Sbjct: 907  ------ERCEGLIKSKI-LLEAKVKELTERLEEEEEMNS----ELVAKKRNLEDKCSSLK 955

Query: 363  REQESYKQMQSEFAARLNKVEMERQNLAEAITLAER---KYSDEKKRVDELQQQVKLYKL 419
            R+ +  +   ++     +  E + +NL+E +T  E    K + EKK + E  QQ  L  L
Sbjct: 956  RDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQT-LDDL 1014

Query: 420  NLESSK-QELIDYKQKATR-------ILQSKEKLINSLKEGS-GFEG-LDSSTASSMELE 469
             +E  K   LI    K  +        L+ ++KL   L+      EG L  S  S M+LE
Sbjct: 1015 QVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLE 1074

Query: 470  ELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESARE---QLQDLHDQIAGQKA 526
               ++K+   E+++K   ++ QL++++ D +   +   +  +E   ++++L ++I  +  
Sbjct: 1075 ---NDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHT 1131

Query: 527  SKQELETELERLKQEFHYIEEDLYRTKNTLQSRI---KDRDEEIQKLRNQLTNKTLSNSS 583
             + ++E +   L +E   I E L        ++I   K R+ E QK+R  L   TL + +
Sbjct: 1132 LRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191

Query: 584  -----QSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSN 635
                 + +  + + +L E +   Q + + L  EK+ L  +++ +   + + S S SN
Sbjct: 1192 TAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSN 1248



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 96/442 (21%), Positives = 188/442 (42%), Gaps = 49/442 (11%)

Query: 223  ELSNLRLENQLLRNEVQSLNQE---MASLLQRSKETQEELNKARARVEKWNADHSKSDRM 279
            ++ NL+   Q L  E   L  E   MAS ++   +++  + +    VE   ++    D  
Sbjct: 1210 QIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ 1269

Query: 280  TRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEG 339
               L   + DL    A   +Q   L  R++E + L+S  T++ +AL  +   + +   E 
Sbjct: 1270 QTQL---IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEE 1326

Query: 340  NSLQNQALQTFQERLHEADATLKR---EQESYKQMQ-------SEFAARLNKVEMERQNL 389
               +N      Q   H+ D   ++   EQE+  ++Q       SE A    K E +    
Sbjct: 1327 TKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQR 1386

Query: 390  AEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSL 449
             E +  A++K +   +  +E  +       +LE +KQ L    +   R L+       +L
Sbjct: 1387 TEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL 1446

Query: 450  KEGSGFEGLDSSTAS-SMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVN--- 505
             +       D   A    +L+E + E E  ++E + L  ++ ++R+  +++  Q      
Sbjct: 1447 DKKQ--RNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRR 1504

Query: 506  EAESAREQLQDLHDQIAG-----QKASK----------------QELETELERLKQEFHY 544
            E ++ +E++ DL +QIA      Q+A K                +E+E  LE  + +   
Sbjct: 1505 ENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILR 1564

Query: 545  IEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTM 604
            ++ +L + K+ L  ++ ++DEEI++L+    ++  + + QS L+  +    + L  K+ M
Sbjct: 1565 VQLELSQVKSELDRKVIEKDEEIEQLKR--NSQRAAEALQSVLDAEIRSRNDALRLKKKM 1622

Query: 605  LESLSTEKNSLVFQLERLEQQM 626
               L    N +  QL    +QM
Sbjct: 1623 EGDL----NEMEIQLGHSNRQM 1640



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 136/687 (19%), Positives = 274/687 (39%), Gaps = 89/687 (12%)

Query: 6    DLAGKAEDLLNRVDQGAATALSRKDNASNIYSKNTDYTELHQQNTDLIYQTGPKSTYISS 65
            D+A   E L         T  + +D  S I +K+   T+L     DL  Q     T    
Sbjct: 1234 DMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH---DLNMQKARLQTQNGE 1290

Query: 66   AADNIRNQKATILAGTANVKVGSRTPVEASHPVENASVPRPS-SHFVRRKKSEPDDELLF 124
             +  +  +++ I   T + +  ++   E    +E  +  + + +H ++   S  D +LL 
Sbjct: 1291 LSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQ--SSRHDCDLLR 1348

Query: 125  DFLNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAA 184
            +     ++E   + E+++              ++S  N  V   +T  E     +T E  
Sbjct: 1349 E---QYEEEQEAKAELQR--------------ALSKANSEVAQWRTKYETDAIQRTEELE 1391

Query: 185  SNSDSSHEGQEESSKENVSSNAACPDHTPTPN-----------DDGKSHEL-----SNLR 228
                   +  +E+ +   ++N+ C     T             D  +SH          R
Sbjct: 1392 EAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQR 1451

Query: 229  LENQLLRNEVQSLNQEMASLLQRSKETQE---ELNKARARVEKWNADHSKSDRMTRGLRA 285
              +++L    Q L++  A L    KE++    EL K R   E+         R  + L+ 
Sbjct: 1452 NFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQE 1511

Query: 286  QVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALE----ALQSEKSRIMQDQSEGNS 341
            ++ DLTE +A     L   +   +  +Q  S    ALE    +L+ E+S+I++ Q E + 
Sbjct: 1512 EISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQ 1571

Query: 342  LQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLN----------KVEMERQNLAE 391
            ++++  +   E+  E +   +  Q + + +QS   A +           K+E +   +  
Sbjct: 1572 VKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEI 1631

Query: 392  AITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKE 451
             +  + R+ ++ +K +  +Q Q+K  +L+L+ + +   D K++   + +    L+  L+E
Sbjct: 1632 QLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEE 1691

Query: 452  GSGFEGLDSSTASSMELEELRHEKEMQREEIQ---------KLMGQIHQLRSELQDMEAQ 502
                      T    E E L     +Q    Q         KL   I Q ++E+++   +
Sbjct: 1692 MKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQE 1751

Query: 503  QVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDL-YRTKNTLQSRIK 561
              N  E A++ + D    +A +   +Q+    LER+K+      +DL +R     Q  +K
Sbjct: 1752 SRNAEEKAKKAITDA-AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1810

Query: 562  DRDEEIQKLRNQLTNKTLSNSSQSE-------------LENRLHQLT-------ETLIQK 601
               ++IQKL N++  + L N    E              E ++ ++T       + +++ 
Sbjct: 1811 GGKKQIQKLENRV--RELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRL 1868

Query: 602  QTMLESLSTEKNSLVFQLERLEQQMNS 628
            Q +++ L  +  S   Q E  E+Q N+
Sbjct: 1869 QDLVDKLQAKVKSYKRQAEEAEEQANT 1895



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 95/455 (20%), Positives = 204/455 (44%), Gaps = 82/455 (18%)

Query: 192  EGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQ--LLRNEVQSLNQEMASLL 249
            E +EE + E V+      D   +   D    EL+  ++E +     N+V++L++EM +L 
Sbjct: 931  EEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTAL- 989

Query: 250  QRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQ 309
                  +E ++K     +     H ++          +DDL      +D    ++K+  +
Sbjct: 990  ------EENISKLTKEKKSLQEAHQQT----------LDDLQ---VEEDKVNGLIKINAK 1030

Query: 310  EADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYK 369
                 L  +T+ LE    ++ ++  D           L+  QE + + +   ++ +E  K
Sbjct: 1031 -----LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLK 1085

Query: 370  QMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKL-YKLNLESSKQEL 428
            + + E +    K++ E+ +  +     ++K  + + R++EL+++++  + L  +  KQ  
Sbjct: 1086 KKEFELSQLQAKIDDEQVHSLQ----FQKKIKELQARIEELEEEIEAEHTLRAKIEKQR- 1140

Query: 429  IDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQ 488
                   + + +  E++   L+E SG      +T++ +E+ + R E E Q+         
Sbjct: 1141 -------SDLARELEEISERLEEASG------ATSAQIEMNKKR-EAEFQK--------- 1177

Query: 489  IHQLRSELQDMEAQQVNEAESAREQLQD----LHDQIAGQKASKQELETELERLKQEFHY 544
               +R +L++   Q    A + R++  D    L +QI   +  KQ+LE E   LK E   
Sbjct: 1178 ---MRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDD 1234

Query: 545  IE---EDLYRTKNTLQ----------SRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRL 591
            +    E L ++K+ ++          S IK +DE+  +L + L      N  ++ L+ + 
Sbjct: 1235 MASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDL------NMQKARLQTQN 1288

Query: 592  HQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQM 626
             +L+  + +K++++  L+  K +L  QLE L++QM
Sbjct: 1289 GELSHRVEEKESLISQLTKSKQALTQQLEELKRQM 1323



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 73/349 (20%), Positives = 158/349 (45%), Gaps = 46/349 (13%)

Query: 310  EADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYK 369
            EA++ ++T  E  E  + E +R    ++    L+ + +   QE+            +   
Sbjct: 848  EAEKEMATMKEDFERTKEELAR---SEARRKELEEKMVSLLQEK-----------NDLQL 893

Query: 370  QMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDE---LQQQVKLYKLNLE---- 422
            Q+QSE    L   E   + L ++  L E K  +  +R++E   +  ++   K NLE    
Sbjct: 894  QVQSE-TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCS 952

Query: 423  SSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEI 482
            S K+++ D +   T++ + K    N +K  S     +  TA    + +L  EK+  +E  
Sbjct: 953  SLKRDIDDLELTLTKVEKEKHATENKVKNLS-----EEMTALEENISKLTKEKKSLQEAH 1007

Query: 483  QKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEF 542
            Q+ +  +         +E  +VN       +L+   D + G    +++L  +LER K++ 
Sbjct: 1008 QQTLDDLQ--------VEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKL 1059

Query: 543  H----YIEE---DLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSN----SSQSELENRL 591
                   +E   DL   K  ++ ++K ++ E+ +L+ ++ ++ + +        EL+ R+
Sbjct: 1060 EGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARI 1119

Query: 592  HQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSIN 640
             +L E +  + T+   +  +++ L  +LE + +++  ASG++S    +N
Sbjct: 1120 EELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMN 1168



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 76/414 (18%), Positives = 189/414 (45%), Gaps = 28/414 (6%)

Query: 228  RLENQLLRNEVQ--SLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRG--- 282
            R + +L R+E +   L ++M SLLQ   + Q ++   ++  E       + + + +    
Sbjct: 862  RTKEELARSEARRKELEEKMVSLLQEKNDLQLQV---QSETENLMDAEERCEGLIKSKIL 918

Query: 283  LRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQ-SEGNS 341
            L A+V +LTE +  ++   + L  + +  +   S+    ++ L+   +++ +++ +  N 
Sbjct: 919  LEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENK 978

Query: 342  LQN--QALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVE---MERQNLAEAITLA 396
            ++N  + +   +E + +     K  QE+++Q   +     +KV         L +     
Sbjct: 979  VKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDL 1038

Query: 397  ERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDY---KQKATRILQSKEKLINSLKEGS 453
            E     EKK   +L++  +  + +L+ S++ ++D    KQ+    L+ KE  ++ L+   
Sbjct: 1039 EGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAK- 1097

Query: 454  GFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQ 513
                +D     S++ ++   E + + EE+++ +   H LR++++   +    E E   E+
Sbjct: 1098 ----IDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISER 1153

Query: 514  LQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQ 573
            L++     + Q    ++ E E ++++++   +EE   + + T  +  K + + + +L  Q
Sbjct: 1154 LEEASGATSAQIEMNKKREAEFQKMRRD---LEEATLQHEATAATLRKKQADSVAELGEQ 1210

Query: 574  LTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMN 627
            + N       + +LE    +L   +    + +E+LS  K+++      +E Q +
Sbjct: 1211 IDN---LQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFS 1261



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 77/367 (20%), Positives = 161/367 (43%), Gaps = 29/367 (7%)

Query: 220  KSHELSNLRLENQLLRNEVQS-LNQEMAS---LLQRSKETQEELNKARARVEKWNADHSK 275
            K  E+  L+  +Q     +QS L+ E+ S    L+  K+ + +LN+   ++   N   ++
Sbjct: 1583 KDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAE 1642

Query: 276  SDRMTRGLRAQVDD----LTEAVAAKDS---QLAVLKVRLQEADQLLSTRTEALEALQSE 328
            + +  R ++ Q+ D    L +A+ + +    QLA+++ R     + L     ALE  Q+E
Sbjct: 1643 TQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALE--QTE 1700

Query: 329  KSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQN 388
            ++R + +Q   ++  +  +Q    +      T K+ +    Q Q+E    + +     + 
Sbjct: 1701 RTRRLSEQELLDA--SDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEK 1758

Query: 389  LAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRIL-----QSKE 443
              +AIT A    ++E K+  +    ++  K NLE + ++L     +A ++      +  +
Sbjct: 1759 AKKAITDAAMM-AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ 1817

Query: 444  KLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQ 503
            KL N ++E      LD       E  +  H+ E + +E+     + H+    LQD+  + 
Sbjct: 1818 KLENRVRELEN--ELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKL 1875

Query: 504  VNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDR 563
              + +S + Q ++  +Q   Q +  + ++ ELE   +     E  + +       R K R
Sbjct: 1876 QAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKL------RAKSR 1929

Query: 564  DEEIQKL 570
            D   QK+
Sbjct: 1930 DVGSQKM 1936


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.123    0.320 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,257,711
Number of Sequences: 37866
Number of extensions: 994603
Number of successful extensions: 16454
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 445
Number of HSP's successfully gapped in prelim test: 1242
Number of HSP's that attempted gapping in prelim test: 6175
Number of HSP's gapped (non-prelim): 5385
length of query: 731
length of database: 18,247,518
effective HSP length: 110
effective length of query: 621
effective length of database: 14,082,258
effective search space: 8745082218
effective search space used: 8745082218
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.