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Search of human proteins with 29826279
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29826279 tubby isoform b [Homo sapiens]
(506 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29826279 tubby isoform b [Homo sapiens] 1001 0.0
gi|19923167 tubby isoform a [Homo sapiens] 971 0.0
gi|21536436 tubby like protein 3 isoform 1 [Homo sapiens] 458 e-129
gi|238550202 tubby like protein 3 isoform 2 [Homo sapiens] 446 e-125
gi|157266334 tubby like protein 1 [Homo sapiens] 420 e-117
gi|238859545 tubby like protein 2 [Homo sapiens] 331 1e-90
gi|55953100 tubby like protein 4 isoform 1 [Homo sapiens] 78 2e-14
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 50 4e-06
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 48 2e-05
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 48 2e-05
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 48 2e-05
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 48 2e-05
gi|239743051 PREDICTED: hypothetical protein XP_002342747 [Homo ... 47 4e-05
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 46 9e-05
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 46 9e-05
gi|55741677 SET domain containing 1A [Homo sapiens] 45 2e-04
gi|153070260 myristoylated alanine-rich protein kinase C substra... 44 5e-04
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora... 42 0.001
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 42 0.002
gi|158854042 hypothetical protein LOC222183 [Homo sapiens] 41 0.002
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens] 41 0.002
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 41 0.002
gi|61742808 hypothetical protein LOC283638 isoform 2 [Homo sapiens] 41 0.003
gi|163644261 hypothetical protein LOC283638 isoform 1 [Homo sapi... 41 0.003
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 40 0.004
gi|21361684 G patch domain containing 1 [Homo sapiens] 40 0.007
gi|21396500 HIRA interacting protein 3 [Homo sapiens] 39 0.009
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 39 0.011
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 39 0.011
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 39 0.011
>gi|29826279 tubby isoform b [Homo sapiens]
Length = 506
Score = 1001 bits (2587), Expect = 0.0
Identities = 506/506 (100%), Positives = 506/506 (100%)
Query: 1 MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRR 60
MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRR
Sbjct: 1 MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRR 60
Query: 61 ARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQG 120
ARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQG
Sbjct: 61 ARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQG 120
Query: 121 GAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQD 180
GAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQD
Sbjct: 121 GAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQD 180
Query: 181 LRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAP 240
LRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAP
Sbjct: 181 LRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAP 240
Query: 241 EQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLA 300
EQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLA
Sbjct: 241 EQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLA 300
Query: 301 GRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLES 360
GRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLES
Sbjct: 301 GRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLES 360
Query: 361 GTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTE 420
GTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTE
Sbjct: 361 GTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTE 420
Query: 421 SIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTM 480
SIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTM
Sbjct: 421 SIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTM 480
Query: 481 DYNYPLCALQAFAIALSSFDSKLACE 506
DYNYPLCALQAFAIALSSFDSKLACE
Sbjct: 481 DYNYPLCALQAFAIALSSFDSKLACE 506
>gi|19923167 tubby isoform a [Homo sapiens]
Length = 561
Score = 971 bits (2510), Expect = 0.0
Identities = 493/493 (100%), Positives = 493/493 (100%)
Query: 14 VLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVES 73
VLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVES
Sbjct: 69 VLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVES 128
Query: 74 YLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKG 133
YLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKG
Sbjct: 129 YLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKG 188
Query: 134 TSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSS 193
TSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSS
Sbjct: 189 TSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSS 248
Query: 194 MSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEE 253
MSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEE
Sbjct: 249 MSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEE 308
Query: 254 FALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYL 313
FALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYL
Sbjct: 309 FALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYL 368
Query: 314 ISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYE 373
ISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYE
Sbjct: 369 ISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYE 428
Query: 374 TNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWN 433
TNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWN
Sbjct: 429 TNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWN 488
Query: 434 DDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFA 493
DDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFA
Sbjct: 489 DDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFA 548
Query: 494 IALSSFDSKLACE 506
IALSSFDSKLACE
Sbjct: 549 IALSSFDSKLACE 561
>gi|21536436 tubby like protein 3 isoform 1 [Homo sapiens]
Length = 442
Score = 458 bits (1179), Expect = e-129
Identities = 251/497 (50%), Positives = 322/497 (64%), Gaps = 71/497 (14%)
Query: 13 SVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVE 72
SV +E +RQ KLD QR LLE++Q+KKR EP MVQ N + R R + R S+EQ PLV
Sbjct: 14 SVFHEEMMKMRQAKLDYQRLLLEKRQRKKRLEPFMVQPNPEARLRRAKPRASDEQTPLVN 73
Query: 73 SYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHK 132
+ S +
Sbjct: 74 CHTPHSNVILH------------------------------------------------- 84
Query: 133 GTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISS 192
G GPAA+ + E P +V + D A++ +TA+ G L+ +Q+ IS
Sbjct: 85 GIDGPAAVLKP-DEVHAPSVSSSVVEED-AENTVDTASKPG-------LQERLQKHDISE 135
Query: 193 SMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDV---EVQ 249
S++FDE E + S S+ L RP+SA+S+ S S + A QP D ++
Sbjct: 136 SVNFDE----ETDGISQSACLE---RPNSASSQNSTDTGTSGSATAA--QPADNLLGDID 186
Query: 250 DLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKT 309
DLE+F PAPQG+T++CRI RDK+GMDRG++PTY+++L++E+ +K+FLLA RKRKKSKT
Sbjct: 187 DLEDFVYSPAPQGVTVRCRIIRDKRGMDRGLFPTYYMYLEKEENQKIFLLAARKRKKSKT 246
Query: 310 SNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAA 369
+NYLIS+DP DLSR G+SY+GKLRSNLMGTKFTVYD G+ P K + T RQELAA
Sbjct: 247 ANYLISIDPVDLSREGESYVGKLRSNLMGTKFTVYDRGICPMKGRGLVGAAHT-RQELAA 305
Query: 370 VCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKT 429
+ YETNVLGFKGPRKMSVI+PGM + H+++ +P+N H++LL+RWQN+ E+++EL NK
Sbjct: 306 ISYETNVLGFKGPRKMSVIIPGMTLNHKQIPYQPQNNHDSLLSRWQNRTMENLVELHNKA 365
Query: 430 PVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCAL 489
PVWN DTQSYVLNF GRVTQASVKNFQI+H NDPDYIVMQFGRVA+DVFT+DYNYPLCA+
Sbjct: 366 PVWNSDTQSYVLNFRGRVTQASVKNFQIVHKNDPDYIVMQFGRVADDVFTLDYNYPLCAV 425
Query: 490 QAFAIALSSFDSKLACE 506
QAF I LSSFDSKLACE
Sbjct: 426 QAFGIGLSSFDSKLACE 442
>gi|238550202 tubby like protein 3 isoform 2 [Homo sapiens]
Length = 501
Score = 446 bits (1148), Expect = e-125
Identities = 245/491 (49%), Positives = 316/491 (64%), Gaps = 71/491 (14%)
Query: 13 SVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVE 72
SV +E +RQ KLD QR LLE++Q+KKR EP MVQ N + R R + R S+EQ PLV
Sbjct: 14 SVFHEEMMKMRQAKLDYQRLLLEKRQRKKRLEPFMVQPNPEARLRRAKPRASDEQTPLVN 73
Query: 73 SYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHK 132
+ S +
Sbjct: 74 CHTPHSNVILH------------------------------------------------- 84
Query: 133 GTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISS 192
G GPAA+ + E P +V + D A++ +TA+ G L+ +Q+ IS
Sbjct: 85 GIDGPAAVLKP-DEVHAPSVSSSVVEED-AENTVDTASKPG-------LQERLQKHDISE 135
Query: 193 SMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDV---EVQ 249
S++FDE E + S S+ L RP+SA+S+ S S + A QP D ++
Sbjct: 136 SVNFDE----ETDGISQSACLE---RPNSASSQNSTDTGTSGSATAA--QPADNLLGDID 186
Query: 250 DLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKT 309
DLE+F PAPQG+T++CRI RDK+GMDRG++PTY+++L++E+ +K+FLLA RKRKKSKT
Sbjct: 187 DLEDFVYSPAPQGVTVRCRIIRDKRGMDRGLFPTYYMYLEKEENQKIFLLAARKRKKSKT 246
Query: 310 SNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAA 369
+NYLIS+DP DLSR G+SY+GKLRSNLMGTKFTVYD G+ P K + T RQELAA
Sbjct: 247 ANYLISIDPVDLSREGESYVGKLRSNLMGTKFTVYDRGICPMKGRGLVGAAHT-RQELAA 305
Query: 370 VCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKT 429
+ YETNVLGFKGPRKMSVI+PGM + H+++ +P+N H++LL+RWQN+ E+++EL NK
Sbjct: 306 ISYETNVLGFKGPRKMSVIIPGMTLNHKQIPYQPQNNHDSLLSRWQNRTMENLVELHNKA 365
Query: 430 PVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCAL 489
PVWN DTQSYVLNF GRVTQASVKNFQI+H NDPDYIVMQFGRVA+DVFT+DYNYPLCA+
Sbjct: 366 PVWNSDTQSYVLNFRGRVTQASVKNFQIVHKNDPDYIVMQFGRVADDVFTLDYNYPLCAV 425
Query: 490 QAFAIALSSFD 500
QAF I LSSFD
Sbjct: 426 QAFGIGLSSFD 436
>gi|157266334 tubby like protein 1 [Homo sapiens]
Length = 542
Score = 420 bits (1080), Expect = e-117
Identities = 223/406 (54%), Positives = 274/406 (67%), Gaps = 35/406 (8%)
Query: 101 PTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSD 160
P P R + G+G RK KK K G + S + P + VG+
Sbjct: 172 PDPPPKPLRVRNKEAPAGEGTKMRKTKK-KGSGEADKDPSGSPASARKSPAAMFLVGE-- 228
Query: 161 HAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPS 220
G + +++KG ++EE+EEE ++ + N +
Sbjct: 229 -----------------GSPDKKALKKKGTPKGAR--KEEEEEEEAATVIKKSNQKGKAK 269
Query: 221 SATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGM 280
+K+ E A +P VEV + EF LRPAPQG T++CR+TRDKKGMDRGM
Sbjct: 270 GKGKKKAKEERAPSPP---------VEVDEPREFVLRPAPQGRTVRCRLTRDKKGMDRGM 320
Query: 281 YPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTK 340
YP+YFLHLD E KKVFLLAGRKRK+SKT+NYLIS+DPT+LSRGG+++IGKLRSNL+G +
Sbjct: 321 YPSYFLHLDTE--KKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNR 378
Query: 341 FTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVS 400
FTV+DNG NPQ+ S+ + S LRQELAAV YETNVLGF+GPR+M+VI+PGM+ +ERV
Sbjct: 379 FTVFDNGQNPQRGYSTNVAS--LRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVP 436
Query: 401 IRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHG 460
IRPRN + LL RWQNK ES+IEL NK PVWNDD+ SY LNF GRVTQASVKNFQI+H
Sbjct: 437 IRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHA 496
Query: 461 NDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE 506
+DPDYIV+QFGRVAED FT+DY YPLCALQAFAIALSSFD KLACE
Sbjct: 497 DDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE 542
Score = 30.4 bits (67), Expect = 4.0
Identities = 26/87 (29%), Positives = 35/87 (40%), Gaps = 18/87 (20%)
Query: 197 DEDEEDEEENSSSSSQL-----NSNTRPSSATSRKSVREAASAP-----SPTAPEQPVDV 246
+EDEEDEEE + + R S+ K R A P SP P +P+ V
Sbjct: 122 EEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRV 181
Query: 247 EVQDLEEFALRPAPQGITIKCRITRDK 273
++ AP G K R T+ K
Sbjct: 182 RNKE--------APAGEGTKMRKTKKK 200
>gi|238859545 tubby like protein 2 [Homo sapiens]
Length = 520
Score = 331 bits (848), Expect = 1e-90
Identities = 202/522 (38%), Positives = 290/522 (55%), Gaps = 34/522 (6%)
Query: 7 SDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEE 66
+D + +L E +R QKL++QR L E+KQ++KRQE LMVQAN D P R+ EE
Sbjct: 5 NDTLMRDILGHELAAMRLQKLEQQRRLFEKKQRQKRQELLMVQANPDASPWLWRSCLREE 64
Query: 67 QA----PLVESYLSSSGSTSYQVQEADS-LASVQLGAT-RPTAPASAKRTKAAATAGG-- 118
+ L +L S ++ S L +V G R RT+A G
Sbjct: 65 RLLGDRGLGNPFLRKKVSEAHLPSGIHSALGTVSCGGDGRGERGLPTPRTEAVFRNLGLQ 124
Query: 119 --------QGGAARKEKKGKHKGTSGPAALAEDKS------EAQGPVQILTVGQSDHAQD 164
A E+ G+ P + +A G+SD +QD
Sbjct: 125 SPFLSWLPDNSDAELEEVSVENGSVSPPPFKQSPRIRRKGWQAHQRPGTRAEGESD-SQD 183
Query: 165 AGETAAGGGERPS-GQDLRATMQRKGISSSMSFDEDEEDEEENSSSSS-----QLNSNTR 218
G+ P+ G D + ++ E E ++SS +L+ +
Sbjct: 184 MGDAHKSPNMGPNPGMDGDCVYENLAFQKEEDLEKKREASESTGTNSSAAHNEELSKALK 243
Query: 219 PSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDR 278
T +R AS A P +D+E + LRPA G ++C +TRDK G+D+
Sbjct: 244 GEGGTDSDHMRHEASL----AIRSPCPGLEEDMEAYVLRPALPGTMMQCYLTRDKHGVDK 299
Query: 279 GMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMG 338
G++P Y+L+L+ D + FLLAGRKR++SKTSNYLIS+DPT LSR GD+++GK+RSN+
Sbjct: 300 GLFPLYYLYLETSDSLQRFLLAGRKRRRSKTSNYLISLDPTHLSRDGDNFVGKVRSNVFS 359
Query: 339 TKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHER 398
TKFT++DNGVNP + T + +RQEL AVCYE NVLG+ GPRKM+VI+PG N ++R
Sbjct: 360 TKFTIFDNGVNPDR-EHLTRNTARIRQELGAVCYEPNVLGYLGPRKMTVILPGTNSQNQR 418
Query: 399 VSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQII 458
++++P NE E+LL+R+Q + + ++ L NKTP W+ + Y LNFHGRVT+ASVKNFQI+
Sbjct: 419 INVQPLNEQESLLSRYQRGDKQGLLLLHNKTPSWDKENGVYTLNFHGRVTRASVKNFQIV 478
Query: 459 HGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFD 500
+++V+QFGRV D FTMD+ +P LQAF+I LSSF+
Sbjct: 479 DPKHQEHLVLQFGRVGPDTFTMDFCFPFSPLQAFSICLSSFN 520
>gi|55953100 tubby like protein 4 isoform 1 [Homo sapiens]
Length = 1543
Score = 77.8 bits (190), Expect = 2e-14
Identities = 39/80 (48%), Positives = 53/80 (66%), Gaps = 5/80 (6%)
Query: 425 LQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQI-IHGNDPDYIVMQFGRVAEDVFTMDYN 483
+ NK P+WN+ TQ Y L+F GRVTQ S KNFQI + G VMQFGR+ + +D+
Sbjct: 1467 MANKQPLWNEATQVYQLDFGGRVTQESAKNFQIELEGRQ----VMQFGRIDGSAYILDFQ 1522
Query: 484 YPLCALQAFAIALSSFDSKL 503
YP A+QAFA+AL++ +L
Sbjct: 1523 YPFSAVQAFAVALANVTQRL 1542
Score = 29.3 bits (64), Expect = 8.8
Identities = 18/69 (26%), Positives = 35/69 (50%), Gaps = 14/69 (20%)
Query: 327 SYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMS 386
+Y+ ++ SN+ GTKF + + L L AV Y+T++L + PR+M+
Sbjct: 594 NYLAQVTSNIWGTKFKIVG-------------LAAFLPTNLGAVIYKTSLLHLQ-PRQMT 639
Query: 387 VIVPGMNMV 395
+ +P + +
Sbjct: 640 IYLPEVRKI 648
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 50.4 bits (119), Expect = 4e-06
Identities = 51/236 (21%), Positives = 90/236 (38%), Gaps = 34/236 (14%)
Query: 37 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASV-- 94
K +K + P+ V+A P+ RA S SSS S+S E + A+
Sbjct: 181 KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK 240
Query: 95 ------QLGATRPTAPASAKRTKAAATAGGQGGAARKEKK------GKHKGTSGPAALAE 142
Q+ A P A+ K++++ ++KK G + P+A
Sbjct: 241 KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPP 300
Query: 143 DKSEAQGPVQILTVGQS--DHAQDAGETAAGGGERPSGQDLRATMQR------------K 188
KS P + Q + ++D+ + + E +A + + +
Sbjct: 301 KKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAE 360
Query: 189 GISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPV 244
S S D E+DE + + + NS+ +P+ T +V+ AA AP+QPV
Sbjct: 361 SSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAA------APKQPV 410
Score = 44.7 bits (104), Expect = 2e-04
Identities = 51/237 (21%), Positives = 91/237 (38%), Gaps = 21/237 (8%)
Query: 19 GRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLV--ESYLS 76
G+ L +K D + E ++ + MV +QAP +S
Sbjct: 413 GQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSD 472
Query: 77 SSGSTSYQVQEADSLASVQ------LGATRPTAPASAKRTKAAATAGGQGGAARKEKKGK 130
S S+S + +E S ++V+ G P+ PASAK+ KA ++ + +E++ K
Sbjct: 473 SDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEK 532
Query: 131 HKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGI 190
KG P A + G S G+ A E + A + K
Sbjct: 533 LKGKGSPRPQAPKAN-----------GTSALTAQNGKAAKNSEEEEEEKKKAAVVVSK-- 579
Query: 191 SSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVE 247
S S+ + E +E + ++ P++ RK + AS+P E+ ++V+
Sbjct: 580 SGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVD 636
Score = 32.0 bits (71), Expect = 1.4
Identities = 49/238 (20%), Positives = 93/238 (39%), Gaps = 34/238 (14%)
Query: 30 QRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLV--------------ESYL 75
+++L Q KK ++ V+++ D S + + E++ P ++
Sbjct: 301 KKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAE 360
Query: 76 SSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTS 135
SSS S+ E D S G T+ ++ A TK+ A + AA K+ G
Sbjct: 361 SSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAV---KPAAAPKQPVG------ 411
Query: 136 GPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGI--SSS 193
G L K+++ + + + + + T + L A +G SSS
Sbjct: 412 GGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSS 471
Query: 194 MSFDEDEEDEEENSSSSSQLN---------SNTRPSSATSRKSVREAASAPSPTAPEQ 242
S E+EEE +S S+ + ++P+SA K+ +S+ ++ E+
Sbjct: 472 DSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEE 529
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/223 (25%), Positives = 88/223 (39%), Gaps = 28/223 (12%)
Query: 49 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQ-----LGATRPTA 103
Q P ++RA++ EE ES S GS S + A + + V+ L +A
Sbjct: 251 QVKGGALPPAKRAKKPEE-----ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
Query: 104 PASAKRTKAAATA--GGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQ--ILTVGQS 159
PA K A A G G A + K GK + S ++ SE + P +L S
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365
Query: 160 DHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSF----DEDEEDEEENSSSSSQLNS 215
G +A E P A + G + + + +ED + E S S + +
Sbjct: 366 GKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Query: 216 NTRPS---------SATSRKSVREAASAPSPTAPEQPVDVEVQ 249
+PS SA +++S R+ A AP+P P +VQ
Sbjct: 426 QAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKTGPAAAQVQ 467
Score = 45.8 bits (107), Expect = 9e-05
Identities = 46/185 (24%), Positives = 79/185 (42%), Gaps = 20/185 (10%)
Query: 53 DGRPRSRRARQSEEQAPLVESYLSS--SGSTSYQVQEADSLASVQLGATRPTAPASAKRT 110
D S + SEE+ P ++ L + SG TS Q+GA A S ++
Sbjct: 338 DSESSSEESSDSEEETPAAKALLQAKASGKTS------------QVGAASAPAKESPRKG 385
Query: 111 KAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAA 170
A A G G A K + GK + S ++ E SE + P Q G++ + A +A
Sbjct: 386 AAPAPPGKTGPAVAKAQAGKREEDS-QSSSEESDSEEEAPAQAKPSGKAPQVRAA---SA 441
Query: 171 GGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 230
E P A ++ G +++ + + EE++ SSS + +S+ +A + V+
Sbjct: 442 PAKESPRKGAAPAPPRKTGPAAAQV--QVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 499
Query: 231 AASAP 235
+P
Sbjct: 500 LGKSP 504
Score = 39.7 bits (91), Expect = 0.007
Identities = 45/207 (21%), Positives = 78/207 (37%), Gaps = 14/207 (6%)
Query: 50 ANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKR 109
A A R ++ S E++ E + + + Q + A + + APA ++
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458
Query: 110 TKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA---- 165
T AA G + + S ALA A Q+ +G+S + A
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALA-----AMNAAQVKPLGKSPQVKPASTMG 513
Query: 166 -GETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS 224
G G G P G+ AT + D + EE + SS ++ + P+ S
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQ--VGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 225 RKSVREA--ASAPSPTAPEQPVDVEVQ 249
++ +A S+P+ P++ V VQ
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQ 598
Score = 39.3 bits (90), Expect = 0.009
Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 34/240 (14%)
Query: 37 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQL 96
K ++ P+ VQ A+ +P + SEE + +S + + T+ Q + A + +
Sbjct: 586 KGPPQKAGPVAVQVKAE-KPMDN-SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 643
Query: 97 GATRPTAPASAK---------RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA 147
+ ASAK + A TA G++ G + ++ E SE
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 148 QGPVQILTVGQSDHAQDAGETAAG-----------------GGERPSGQDLRATMQRKGI 190
+ +TVGQ+ + A G P+ ++A Q
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 763
Query: 191 SSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSP-TAPEQPVDVEVQ 249
SS E+E D EE ++S +Q+ ++ + + A + + A SA +AP + V Q
Sbjct: 764 SS-----EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 818
Score = 29.3 bits (64), Expect = 8.8
Identities = 41/202 (20%), Positives = 71/202 (35%), Gaps = 24/202 (11%)
Query: 60 RARQSEEQAPLV--ESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAG 117
R R++EE A L ++ +S STS +E + + AT A ++ A +
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 118 GQGGAARKEKKGKHKGTSGP--------AALAEDKSEAQGPVQILTVGQSDHAQDAGETA 169
+ A + +K G S P A L KS + ++ G
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 170 AGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVR 229
A G G +S + + E+ SSSS + + +PS ++
Sbjct: 181 AFGAAAKPGM--------------VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKAS 226
Query: 230 EAASAPSPTAPEQPVDVEVQDL 251
++ SP P +V D+
Sbjct: 227 SVSTKESPARKAAPAPGKVGDV 248
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/223 (25%), Positives = 88/223 (39%), Gaps = 28/223 (12%)
Query: 49 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQ-----LGATRPTA 103
Q P ++RA++ EE ES S GS S + A + + V+ L +A
Sbjct: 251 QVKGGALPPAKRAKKPEE-----ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
Query: 104 PASAKRTKAAATA--GGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQ--ILTVGQS 159
PA K A A G G A + K GK + S ++ SE + P +L S
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365
Query: 160 DHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSF----DEDEEDEEENSSSSSQLNS 215
G +A E P A + G + + + +ED + E S S + +
Sbjct: 366 GKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Query: 216 NTRPS---------SATSRKSVREAASAPSPTAPEQPVDVEVQ 249
+PS SA +++S R+ A AP+P P +VQ
Sbjct: 426 QAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKTGPAAAQVQ 467
Score = 45.8 bits (107), Expect = 9e-05
Identities = 46/185 (24%), Positives = 79/185 (42%), Gaps = 20/185 (10%)
Query: 53 DGRPRSRRARQSEEQAPLVESYLSS--SGSTSYQVQEADSLASVQLGATRPTAPASAKRT 110
D S + SEE+ P ++ L + SG TS Q+GA A S ++
Sbjct: 338 DSESSSEESSDSEEETPAAKALLQAKASGKTS------------QVGAASAPAKESPRKG 385
Query: 111 KAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAA 170
A A G G A K + GK + S ++ E SE + P Q G++ + A +A
Sbjct: 386 AAPAPPGKTGPAVAKAQAGKREEDS-QSSSEESDSEEEAPAQAKPSGKAPQVRAA---SA 441
Query: 171 GGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 230
E P A ++ G +++ + + EE++ SSS + +S+ +A + V+
Sbjct: 442 PAKESPRKGAAPAPPRKTGPAAAQV--QVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 499
Query: 231 AASAP 235
+P
Sbjct: 500 LGKSP 504
Score = 39.7 bits (91), Expect = 0.007
Identities = 45/207 (21%), Positives = 78/207 (37%), Gaps = 14/207 (6%)
Query: 50 ANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKR 109
A A R ++ S E++ E + + + Q + A + + APA ++
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458
Query: 110 TKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA---- 165
T AA G + + S ALA A Q+ +G+S + A
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALA-----AMNAAQVKPLGKSPQVKPASTMG 513
Query: 166 -GETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS 224
G G G P G+ AT + D + EE + SS ++ + P+ S
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQ--VGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 225 RKSVREA--ASAPSPTAPEQPVDVEVQ 249
++ +A S+P+ P++ V VQ
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQ 598
Score = 39.3 bits (90), Expect = 0.009
Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 34/240 (14%)
Query: 37 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQL 96
K ++ P+ VQ A+ +P + SEE + +S + + T+ Q + A + +
Sbjct: 586 KGPPQKAGPVAVQVKAE-KPMDN-SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 643
Query: 97 GATRPTAPASAK---------RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA 147
+ ASAK + A TA G++ G + ++ E SE
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 148 QGPVQILTVGQSDHAQDAGETAAG-----------------GGERPSGQDLRATMQRKGI 190
+ +TVGQ+ + A G P+ ++A Q
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 763
Query: 191 SSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSP-TAPEQPVDVEVQ 249
SS E+E D EE ++S +Q+ ++ + + A + + A SA +AP + V Q
Sbjct: 764 SS-----EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 818
Score = 35.8 bits (81), Expect = 0.094
Identities = 47/212 (22%), Positives = 71/212 (33%), Gaps = 31/212 (14%)
Query: 49 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAK 108
QA A PR RA +S ++ SSS S V A + + T P +
Sbjct: 977 QAQAASTPRKARASESTARS-------SSSESEDEDVIPATQCLTPGIRTNVVTMPTAHP 1029
Query: 109 RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA-----QGPVQILTVGQSD--- 160
R A+ G + + K GPA K+ A Q +++L S+
Sbjct: 1030 RIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP 1089
Query: 161 ---HAQDAGETAAGGGERPSGQDLRATMQRKG-----------ISSSMSFDEDEEDEEEN 206
Q + + G P+ ++Q KG + + E +D E++
Sbjct: 1090 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDS 1149
Query: 207 SSSSSQLNSNTRPSSATSRKSVREAASAPSPT 238
S SSS S KS PS T
Sbjct: 1150 SDSSS--GSEEDGEGPQGAKSAHTLGPTPSRT 1179
Score = 29.3 bits (64), Expect = 8.8
Identities = 41/202 (20%), Positives = 71/202 (35%), Gaps = 24/202 (11%)
Query: 60 RARQSEEQAPLV--ESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAG 117
R R++EE A L ++ +S STS +E + + AT A ++ A +
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 118 GQGGAARKEKKGKHKGTSGP--------AALAEDKSEAQGPVQILTVGQSDHAQDAGETA 169
+ A + +K G S P A L KS + ++ G
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 170 AGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVR 229
A G G +S + + E+ SSSS + + +PS ++
Sbjct: 181 AFGAAAKPGM--------------VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKAS 226
Query: 230 EAASAPSPTAPEQPVDVEVQDL 251
++ SP P +V D+
Sbjct: 227 SVSTKESPARKAAPAPGKVGDV 248
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/223 (25%), Positives = 88/223 (39%), Gaps = 28/223 (12%)
Query: 49 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQ-----LGATRPTA 103
Q P ++RA++ EE ES S GS S + A + + V+ L +A
Sbjct: 251 QVKGGALPPAKRAKKPEE-----ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
Query: 104 PASAKRTKAAATA--GGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQ--ILTVGQS 159
PA K A A G G A + K GK + S ++ SE + P +L S
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365
Query: 160 DHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSF----DEDEEDEEENSSSSSQLNS 215
G +A E P A + G + + + +ED + E S S + +
Sbjct: 366 GKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Query: 216 NTRPS---------SATSRKSVREAASAPSPTAPEQPVDVEVQ 249
+PS SA +++S R+ A AP+P P +VQ
Sbjct: 426 QAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKTGPAAAQVQ 467
Score = 45.8 bits (107), Expect = 9e-05
Identities = 46/185 (24%), Positives = 79/185 (42%), Gaps = 20/185 (10%)
Query: 53 DGRPRSRRARQSEEQAPLVESYLSS--SGSTSYQVQEADSLASVQLGATRPTAPASAKRT 110
D S + SEE+ P ++ L + SG TS Q+GA A S ++
Sbjct: 338 DSESSSEESSDSEEETPAAKALLQAKASGKTS------------QVGAASAPAKESPRKG 385
Query: 111 KAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAA 170
A A G G A K + GK + S ++ E SE + P Q G++ + A +A
Sbjct: 386 AAPAPPGKTGPAVAKAQAGKREEDS-QSSSEESDSEEEAPAQAKPSGKAPQVRAA---SA 441
Query: 171 GGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 230
E P A ++ G +++ + + EE++ SSS + +S+ +A + V+
Sbjct: 442 PAKESPRKGAAPAPPRKTGPAAAQV--QVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 499
Query: 231 AASAP 235
+P
Sbjct: 500 LGKSP 504
Score = 39.7 bits (91), Expect = 0.007
Identities = 45/207 (21%), Positives = 78/207 (37%), Gaps = 14/207 (6%)
Query: 50 ANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKR 109
A A R ++ S E++ E + + + Q + A + + APA ++
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458
Query: 110 TKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA---- 165
T AA G + + S ALA A Q+ +G+S + A
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALA-----AMNAAQVKPLGKSPQVKPASTMG 513
Query: 166 -GETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS 224
G G G P G+ AT + D + EE + SS ++ + P+ S
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQ--VGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 225 RKSVREA--ASAPSPTAPEQPVDVEVQ 249
++ +A S+P+ P++ V VQ
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQ 598
Score = 39.3 bits (90), Expect = 0.009
Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 34/240 (14%)
Query: 37 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQL 96
K ++ P+ VQ A+ +P + SEE + +S + + T+ Q + A + +
Sbjct: 586 KGPPQKAGPVAVQVKAE-KPMDN-SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 643
Query: 97 GATRPTAPASAK---------RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA 147
+ ASAK + A TA G++ G + ++ E SE
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 148 QGPVQILTVGQSDHAQDAGETAAG-----------------GGERPSGQDLRATMQRKGI 190
+ +TVGQ+ + A G P+ ++A Q
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 763
Query: 191 SSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSP-TAPEQPVDVEVQ 249
SS E+E D EE ++S +Q+ ++ + + A + + A SA +AP + V Q
Sbjct: 764 SS-----EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 818
Score = 29.3 bits (64), Expect = 8.8
Identities = 41/202 (20%), Positives = 71/202 (35%), Gaps = 24/202 (11%)
Query: 60 RARQSEEQAPLV--ESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAG 117
R R++EE A L ++ +S STS +E + + AT A ++ A +
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 118 GQGGAARKEKKGKHKGTSGP--------AALAEDKSEAQGPVQILTVGQSDHAQDAGETA 169
+ A + +K G S P A L KS + ++ G
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 170 AGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVR 229
A G G +S + + E+ SSSS + + +PS ++
Sbjct: 181 AFGAAAKPGM--------------VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKAS 226
Query: 230 EAASAPSPTAPEQPVDVEVQDL 251
++ SP P +V D+
Sbjct: 227 SVSTKESPARKAAPAPGKVGDV 248
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/223 (25%), Positives = 88/223 (39%), Gaps = 28/223 (12%)
Query: 49 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQ-----LGATRPTA 103
Q P ++RA++ EE ES S GS S + A + + V+ L +A
Sbjct: 251 QVKGGALPPAKRAKKPEE-----ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
Query: 104 PASAKRTKAAATA--GGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQ--ILTVGQS 159
PA K A A G G A + K GK + S ++ SE + P +L S
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365
Query: 160 DHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSF----DEDEEDEEENSSSSSQLNS 215
G +A E P A + G + + + +ED + E S S + +
Sbjct: 366 GKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Query: 216 NTRPS---------SATSRKSVREAASAPSPTAPEQPVDVEVQ 249
+PS SA +++S R+ A AP+P P +VQ
Sbjct: 426 QAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKTGPAAAQVQ 467
Score = 45.8 bits (107), Expect = 9e-05
Identities = 46/185 (24%), Positives = 79/185 (42%), Gaps = 20/185 (10%)
Query: 53 DGRPRSRRARQSEEQAPLVESYLSS--SGSTSYQVQEADSLASVQLGATRPTAPASAKRT 110
D S + SEE+ P ++ L + SG TS Q+GA A S ++
Sbjct: 338 DSESSSEESSDSEEETPAAKALLQAKASGKTS------------QVGAASAPAKESPRKG 385
Query: 111 KAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAA 170
A A G G A K + GK + S ++ E SE + P Q G++ + A +A
Sbjct: 386 AAPAPPGKTGPAVAKAQAGKREEDS-QSSSEESDSEEEAPAQAKPSGKAPQVRAA---SA 441
Query: 171 GGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 230
E P A ++ G +++ + + EE++ SSS + +S+ +A + V+
Sbjct: 442 PAKESPRKGAAPAPPRKTGPAAAQV--QVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 499
Query: 231 AASAP 235
+P
Sbjct: 500 LGKSP 504
Score = 39.7 bits (91), Expect = 0.007
Identities = 45/207 (21%), Positives = 78/207 (37%), Gaps = 14/207 (6%)
Query: 50 ANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKR 109
A A R ++ S E++ E + + + Q + A + + APA ++
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458
Query: 110 TKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA---- 165
T AA G + + S ALA A Q+ +G+S + A
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALA-----AMNAAQVKPLGKSPQVKPASTMG 513
Query: 166 -GETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS 224
G G G P G+ AT + D + EE + SS ++ + P+ S
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQ--VGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 225 RKSVREA--ASAPSPTAPEQPVDVEVQ 249
++ +A S+P+ P++ V VQ
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQ 598
Score = 39.3 bits (90), Expect = 0.009
Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 34/240 (14%)
Query: 37 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQL 96
K ++ P+ VQ A+ +P + SEE + +S + + T+ Q + A + +
Sbjct: 586 KGPPQKAGPVAVQVKAE-KPMDN-SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 643
Query: 97 GATRPTAPASAK---------RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA 147
+ ASAK + A TA G++ G + ++ E SE
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 148 QGPVQILTVGQSDHAQDAGETAAG-----------------GGERPSGQDLRATMQRKGI 190
+ +TVGQ+ + A G P+ ++A Q
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 763
Query: 191 SSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSP-TAPEQPVDVEVQ 249
SS E+E D EE ++S +Q+ ++ + + A + + A SA +AP + V Q
Sbjct: 764 SS-----EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 818
Score = 29.3 bits (64), Expect = 8.8
Identities = 41/202 (20%), Positives = 71/202 (35%), Gaps = 24/202 (11%)
Query: 60 RARQSEEQAPLV--ESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAG 117
R R++EE A L ++ +S STS +E + + AT A ++ A +
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 118 GQGGAARKEKKGKHKGTSGP--------AALAEDKSEAQGPVQILTVGQSDHAQDAGETA 169
+ A + +K G S P A L KS + ++ G
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 170 AGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVR 229
A G G +S + + E+ SSSS + + +PS ++
Sbjct: 181 AFGAAAKPGM--------------VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKAS 226
Query: 230 EAASAPSPTAPEQPVDVEVQDL 251
++ SP P +V D+
Sbjct: 227 SVSTKESPARKAAPAPGKVGDV 248
>gi|239743051 PREDICTED: hypothetical protein XP_002342747 [Homo
sapiens]
Length = 306
Score = 47.0 bits (110), Expect = 4e-05
Identities = 55/213 (25%), Positives = 85/213 (39%), Gaps = 37/213 (17%)
Query: 38 QKKKRQEPLMVQANADGRPRSRR---------ARQSEEQAPLVESYLSSSGSTSYQVQEA 88
+K+K Q+P A G+ R R A+ EE+A + SS T +
Sbjct: 85 EKRKPQQPQRRPAGGTGQRRGSRSSSSADQQGAQDREEEAAAAPAPTSSGHRTEKR---- 140
Query: 89 DSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAE-DKSEA 147
Q RP A +R + + Q A +E+ + T+ P + ++E
Sbjct: 141 ----KPQQPQCRPAAGTGQRRGSGCSPSADQQRAQDREE----EATAAPVPTSSGHRTEK 192
Query: 148 QGPVQILTVGQSDHAQDAGETAAGGGER--PSGQDLRATMQRKGISSSMSFDEDEEDEEE 205
+ +Q+ Q AG T G R PS Q T QR+G SS S D+ + E
Sbjct: 193 RKRLQL-------QCQPAGGTGQRRGSRSSPSRQPAGGTGQRRGSRSSPSADQQRAQDRE 245
Query: 206 NSSSSSQLNSNTRPSSATSRKSVREAASAPSPT 238
++ Q RP+ T ++ R A+AP PT
Sbjct: 246 EEAAQPQ----RRPAGGTGQR--RGTAAAPVPT 272
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 45.8 bits (107), Expect = 9e-05
Identities = 46/185 (24%), Positives = 79/185 (42%), Gaps = 20/185 (10%)
Query: 53 DGRPRSRRARQSEEQAPLVESYLSS--SGSTSYQVQEADSLASVQLGATRPTAPASAKRT 110
D S + SEE+ P ++ L + SG TS Q+GA A S ++
Sbjct: 261 DSESSSEESSDSEEETPAAKALLQAKASGKTS------------QVGAASAPAKESPRKG 308
Query: 111 KAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAA 170
A A G G A K + GK + S ++ E SE + P Q G++ + A +A
Sbjct: 309 AAPAPPGKTGPAVAKAQAGKREEDS-QSSSEESDSEEEAPAQAKPSGKAPQVRAA---SA 364
Query: 171 GGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 230
E P A ++ G +++ + + EE++ SSS + +S+ +A + V+
Sbjct: 365 PAKESPRKGAAPAPPRKTGPAAAQV--QVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 422
Query: 231 AASAP 235
+P
Sbjct: 423 LGKSP 427
Score = 45.4 bits (106), Expect = 1e-04
Identities = 60/248 (24%), Positives = 97/248 (39%), Gaps = 39/248 (15%)
Query: 33 LLEQKQKKKRQEP-----LMVQANADG---------RPRSRRARQSEEQAPLVESYLSSS 78
LL K +K EP L+ + +G +P A Q++ + E SSS
Sbjct: 151 LLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSS---EDTSSSS 207
Query: 79 GSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATA--GGQGGAARKEKKGKHKGTSG 136
T +V+ ++ + V+ + APA K A A G G A + K GK + S
Sbjct: 208 DETDVEVKASEKILQVRAAS----APAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSE 263
Query: 137 PAALAEDKSEAQGPVQ--ILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSM 194
++ SE + P +L S G +A E P A + G + +
Sbjct: 264 SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAK 323
Query: 195 SF----DEDEEDEEENSSSSSQLNSNTRPS---------SATSRKSVREAASAPSPTAPE 241
+ +ED + E S S + + +PS SA +++S R+ A AP+P
Sbjct: 324 AQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKT 382
Query: 242 QPVDVEVQ 249
P +VQ
Sbjct: 383 GPAAAQVQ 390
Score = 39.7 bits (91), Expect = 0.007
Identities = 45/207 (21%), Positives = 78/207 (37%), Gaps = 14/207 (6%)
Query: 50 ANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKR 109
A A R ++ S E++ E + + + Q + A + + APA ++
Sbjct: 322 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 381
Query: 110 TKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA---- 165
T AA G + + S ALA A Q+ +G+S + A
Sbjct: 382 TGPAAAQVQVGKQEEDSRSSSEESDSDREALA-----AMNAAQVKPLGKSPQVKPASTMG 436
Query: 166 -GETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS 224
G G G P G+ AT + D + EE + SS ++ + P+ S
Sbjct: 437 MGPLGKGAGPVPPGKVGPATPSAQ--VGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 494
Query: 225 RKSVREA--ASAPSPTAPEQPVDVEVQ 249
++ +A S+P+ P++ V VQ
Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQ 521
Score = 39.3 bits (90), Expect = 0.009
Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 34/240 (14%)
Query: 37 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQL 96
K ++ P+ VQ A+ +P + SEE + +S + + T+ Q + A + +
Sbjct: 509 KGPPQKAGPVAVQVKAE-KPMDN-SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 566
Query: 97 GATRPTAPASAK---------RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA 147
+ ASAK + A TA G++ G + ++ E SE
Sbjct: 567 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626
Query: 148 QGPVQILTVGQSDHAQDAGETAAG-----------------GGERPSGQDLRATMQRKGI 190
+ +TVGQ+ + A G P+ ++A Q
Sbjct: 627 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 686
Query: 191 SSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSP-TAPEQPVDVEVQ 249
SS E+E D EE ++S +Q+ ++ + + A + + A SA +AP + V Q
Sbjct: 687 SS-----EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 741
Score = 35.4 bits (80), Expect = 0.12
Identities = 49/228 (21%), Positives = 80/228 (35%), Gaps = 34/228 (14%)
Query: 49 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAK 108
QA A PR RA +S ++ SSS S V A + + T P +
Sbjct: 900 QAQAASTPRKARASESTARS-------SSSESEDEDVIPATQCLTPGIRTNVVTMPTAHP 952
Query: 109 RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA-----QGPVQILTVGQSD--- 160
R A+ G + + K GPA K+ A Q +++L S+
Sbjct: 953 RIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP 1012
Query: 161 ---HAQDAGETAAGGGERPSGQDLRATMQRKG-----------ISSSMSFDEDEEDEEEN 206
Q + + G P+ ++Q KG + + E +D E++
Sbjct: 1013 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDS 1072
Query: 207 SSSSSQLNSNTR-PSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEE 253
S SSS + P A S ++ P+P+ E V+ + E
Sbjct: 1073 SDSSSGSEEDGEGPQGAKSAHTL----VGPTPSRTETLVEETAAESSE 1116
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 45.8 bits (107), Expect = 9e-05
Identities = 46/185 (24%), Positives = 79/185 (42%), Gaps = 20/185 (10%)
Query: 53 DGRPRSRRARQSEEQAPLVESYLSS--SGSTSYQVQEADSLASVQLGATRPTAPASAKRT 110
D S + SEE+ P ++ L + SG TS Q+GA A S ++
Sbjct: 261 DSESSSEESSDSEEETPAAKALLQAKASGKTS------------QVGAASAPAKESPRKG 308
Query: 111 KAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAA 170
A A G G A K + GK + S ++ E SE + P Q G++ + A +A
Sbjct: 309 AAPAPPGKTGPAVAKAQAGKREEDS-QSSSEESDSEEEAPAQAKPSGKAPQVRAA---SA 364
Query: 171 GGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 230
E P A ++ G +++ + + EE++ SSS + +S+ +A + V+
Sbjct: 365 PAKESPRKGAAPAPPRKTGPAAAQV--QVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 422
Query: 231 AASAP 235
+P
Sbjct: 423 LGKSP 427
Score = 45.4 bits (106), Expect = 1e-04
Identities = 60/248 (24%), Positives = 97/248 (39%), Gaps = 39/248 (15%)
Query: 33 LLEQKQKKKRQEP-----LMVQANADG---------RPRSRRARQSEEQAPLVESYLSSS 78
LL K +K EP L+ + +G +P A Q++ + E SSS
Sbjct: 151 LLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSS---EDTSSSS 207
Query: 79 GSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATA--GGQGGAARKEKKGKHKGTSG 136
T +V+ ++ + V+ + APA K A A G G A + K GK + S
Sbjct: 208 DETDVEVKASEKILQVRAAS----APAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSE 263
Query: 137 PAALAEDKSEAQGPVQ--ILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSM 194
++ SE + P +L S G +A E P A + G + +
Sbjct: 264 SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAK 323
Query: 195 SF----DEDEEDEEENSSSSSQLNSNTRPS---------SATSRKSVREAASAPSPTAPE 241
+ +ED + E S S + + +PS SA +++S R+ A AP+P
Sbjct: 324 AQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKT 382
Query: 242 QPVDVEVQ 249
P +VQ
Sbjct: 383 GPAAAQVQ 390
Score = 39.7 bits (91), Expect = 0.007
Identities = 45/207 (21%), Positives = 78/207 (37%), Gaps = 14/207 (6%)
Query: 50 ANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKR 109
A A R ++ S E++ E + + + Q + A + + APA ++
Sbjct: 322 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 381
Query: 110 TKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA---- 165
T AA G + + S ALA A Q+ +G+S + A
Sbjct: 382 TGPAAAQVQVGKQEEDSRSSSEESDSDREALA-----AMNAAQVKPLGKSPQVKPASTMG 436
Query: 166 -GETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS 224
G G G P G+ AT + D + EE + SS ++ + P+ S
Sbjct: 437 MGPLGKGAGPVPPGKVGPATPSAQ--VGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 494
Query: 225 RKSVREA--ASAPSPTAPEQPVDVEVQ 249
++ +A S+P+ P++ V VQ
Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQ 521
Score = 39.3 bits (90), Expect = 0.009
Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 34/240 (14%)
Query: 37 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQL 96
K ++ P+ VQ A+ +P + SEE + +S + + T+ Q + A + +
Sbjct: 509 KGPPQKAGPVAVQVKAE-KPMDN-SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 566
Query: 97 GATRPTAPASAK---------RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA 147
+ ASAK + A TA G++ G + ++ E SE
Sbjct: 567 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626
Query: 148 QGPVQILTVGQSDHAQDAGETAAG-----------------GGERPSGQDLRATMQRKGI 190
+ +TVGQ+ + A G P+ ++A Q
Sbjct: 627 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 686
Query: 191 SSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSP-TAPEQPVDVEVQ 249
SS E+E D EE ++S +Q+ ++ + + A + + A SA +AP + V Q
Sbjct: 687 SS-----EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 741
Score = 35.8 bits (81), Expect = 0.094
Identities = 47/212 (22%), Positives = 71/212 (33%), Gaps = 31/212 (14%)
Query: 49 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAK 108
QA A PR RA +S ++ SSS S V A + + T P +
Sbjct: 900 QAQAASTPRKARASESTARS-------SSSESEDEDVIPATQCLTPGIRTNVVTMPTAHP 952
Query: 109 RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA-----QGPVQILTVGQSD--- 160
R A+ G + + K GPA K+ A Q +++L S+
Sbjct: 953 RIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP 1012
Query: 161 ---HAQDAGETAAGGGERPSGQDLRATMQRKG-----------ISSSMSFDEDEEDEEEN 206
Q + + G P+ ++Q KG + + E +D E++
Sbjct: 1013 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDS 1072
Query: 207 SSSSSQLNSNTRPSSATSRKSVREAASAPSPT 238
S SSS S KS PS T
Sbjct: 1073 SDSSS--GSEEDGEGPQGAKSAHTLGPTPSRT 1102
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 44.7 bits (104), Expect = 2e-04
Identities = 45/211 (21%), Positives = 72/211 (34%), Gaps = 5/211 (2%)
Query: 39 KKKRQEPLMV-QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLG 97
K KR+EP + +A+ + RPR + +E P E G + + D + G
Sbjct: 894 KVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDE----ERG 949
Query: 98 ATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVG 157
T+ S A + + + E+ + A D ++ + V
Sbjct: 950 KTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDE 1009
Query: 158 QSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNT 217
+SD + A GE S D ++ SSS S + SSS
Sbjct: 1010 ESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEE 1069
Query: 218 RPSSATSRKSVREAASAPSPTAPEQPVDVEV 248
RP++ S P+P E PV V
Sbjct: 1070 RPAALPSASPPPREVPVPTPAPVEVPVPERV 1100
Score = 36.6 bits (83), Expect = 0.055
Identities = 26/85 (30%), Positives = 37/85 (43%), Gaps = 7/85 (8%)
Query: 159 SDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTR 218
+D +A E E P Q L+ Q++ +E EE+EEE+S SSS +
Sbjct: 1332 ADEVLEAPEVVVAEAEEPKPQQLQ---QQREEGEEEGEEEGEEEEEESSDSSSSSDG--- 1385
Query: 219 PSSATSRKSVREAASAPSPTAPEQP 243
A R+S+R A P P P
Sbjct: 1386 -EGALRRRSLRSHARRRRPPPPPPP 1409
>gi|153070260 myristoylated alanine-rich protein kinase C substrate
[Homo sapiens]
Length = 332
Score = 43.5 bits (101), Expect = 5e-04
Identities = 53/232 (22%), Positives = 88/232 (37%), Gaps = 17/232 (7%)
Query: 30 QRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEAD 89
+ A+ K QE V+ N D P + + EE L ++GS +E
Sbjct: 21 EAAVASSPSKANGQENGHVKVNGDASPAAAESGAKEE--------LQANGSAPAADKEEP 72
Query: 90 SLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQG 149
+ A GA P+A A++ + AA A + GA+ EK+ G AA + A+G
Sbjct: 73 AAAGS--GAASPSA---AEKGEPAAAAAPEAGASPVEKEAP---AEGEAAEPGSPTAAEG 124
Query: 150 PVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSS 209
S + G T + E P + R + ++ S SF +++++ E +
Sbjct: 125 EAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNKKEAGEGGEA 184
Query: 210 SSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQ 261
+ + +A + A A S P + E EE A PQ
Sbjct: 185 EAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAPGE-EAAAGEEGAAGGDPQ 235
Score = 33.5 bits (75), Expect = 0.47
Identities = 43/156 (27%), Positives = 61/156 (39%), Gaps = 21/156 (13%)
Query: 106 SAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA 165
S K+ K A GG+ A E GK + G AA A + A G Q G+ A +
Sbjct: 170 SFKKNKKEAGEGGEAEAPAAEG-GKDEAAGGAAAAAAEAGAASGE-QAAAPGEEAAAGEE 227
Query: 166 GETAAGGGERPSGQDLRATMQRKGISS--SMSFDEDEEDEEENSSSSSQLNSNTRPSSAT 223
G AAGG + + A K +S + + +E + EE+ + + +SA
Sbjct: 228 G--AAGGDPQEAKPQEAAVAPEKPPASDETKAAEEPSKVEEKKAEEAG--------ASAA 277
Query: 224 SRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPA 259
A APS P P + E EE A A
Sbjct: 278 -------ACEAPSAAGPGAPPEQEAAPAEEPAAAAA 306
>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 1 [Homo sapiens]
Length = 559
Score = 42.4 bits (98), Expect = 0.001
Identities = 53/253 (20%), Positives = 97/253 (38%), Gaps = 35/253 (13%)
Query: 2 TSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRA 61
TSKPH + ++ +R R E K K E +++ D +
Sbjct: 191 TSKPHK--------------VTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEG 236
Query: 62 R-QSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQG 120
R EE+AP ++ + + + S + G P P +K ATA
Sbjct: 237 RLPKEEKAPPPKAAFKEPKMALKETKLEST--SPKGGPPPPPPPPPRASSKRPATADSPK 294
Query: 121 GAARKEKKGKHKGT-SGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQ 179
+A+K+KK KG+ S P S + + A+D T G+
Sbjct: 295 PSAKKQKKSSSKGSRSAPGTSPRTSSSS-------SFSDKKPAKDKSST--------RGE 339
Query: 180 DLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTA 239
++A + + ++ +E ++E + S S +S + SS++ S ++ PS
Sbjct: 340 KVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSS--DSDFEPSQNH 397
Query: 240 PEQPVDVEVQDLE 252
+ P+ V+DL+
Sbjct: 398 SQGPLRSMVEDLQ 410
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 41.6 bits (96), Expect = 0.002
Identities = 59/284 (20%), Positives = 107/284 (37%), Gaps = 47/284 (16%)
Query: 6 HSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSE 65
H +++ L++ R+Q + + + ++ ++ K Q A S S+
Sbjct: 2677 HLEFLRDEELEERREKRRKQLAEEETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSD 2736
Query: 66 EQAPLVESYLSSSGSTSYQVQEAD----SLASVQLGATRPTAPASAKRTKAAATAGGQGG 121
P+ +SY ++ ST E+ +L S Q T PT PA + + + G+GG
Sbjct: 2737 G-TPMPDSYPTTPSSTDAATSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGG 2795
Query: 122 AARK---EKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA------------- 165
++ + + + G + P+ AE P +T + A+D+
Sbjct: 2796 SSTQLLMPVEPEELGPTRPSGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGS 2855
Query: 166 ----------------GET-AAGGGERP------SGQDLRATMQRKGISSSMSFDEDEED 202
G+T AAG E+P G A + +G S E +
Sbjct: 2856 PMDTSSLASCTLEEAVGDTSAAGSSEQPRAGSSTPGDAPPAVAEVQGRSDGSG--ESAQP 2913
Query: 203 EEENSSSSSQLNSNTRPSS-ATSRKSVREAASAPSPTAPEQPVD 245
E++S +S +S+TR S+ A S R P P+ + D
Sbjct: 2914 PEDSSPPASSESSSTRDSAVAISGADSRGILEEPLPSTSSEEED 2957
>gi|158854042 hypothetical protein LOC222183 [Homo sapiens]
Length = 653
Score = 41.2 bits (95), Expect = 0.002
Identities = 51/229 (22%), Positives = 82/229 (35%), Gaps = 34/229 (14%)
Query: 23 RQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTS 82
R+++ R R+ + K+K+K +E + GR RS R +P + S+ S S S S
Sbjct: 219 RRKRRHRSRSS-KCKRKEKNKEKKRPHTESPGR-RSHRHSSGSSHSPSLSSHYSDSRSPS 276
Query: 83 Y----QVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSG-- 136
E S + +R +P+ + GG G ++ G H G G
Sbjct: 277 RLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSG-----QRSGAHGGRPGSA 331
Query: 137 ---------PAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQR 187
P+ DK+ A P +S + A + GG G R +R
Sbjct: 332 HSPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAPSSQGRGGRAAGGAGRRRRRRR 391
Query: 188 KGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPS 236
+ +S+S+ + RP A R S R + A S
Sbjct: 392 R------------RRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARS 428
Score = 33.9 bits (76), Expect = 0.36
Identities = 54/234 (23%), Positives = 89/234 (38%), Gaps = 41/234 (17%)
Query: 20 RNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSG 79
R R + A K+KKK++ G RSR+ R+ E + S G
Sbjct: 152 RGYRTKHWSSSSASPPPKKKKKKK---------GGHRRSRKKRRLESEC--------SCG 194
Query: 80 STSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKH-------- 131
S+S ++ S+ + R + + KR + ++ + KEKK H
Sbjct: 195 SSSPLRKKKKSVKKHR--RDRSDSGSRRKRRHRSRSSKCKRKEKNKEKKRPHTESPGRRS 252
Query: 132 ----KGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPS--GQDLRATM 185
G+S +L+ S+++ P + L+ D + G + G PS G +
Sbjct: 253 HRHSSGSSHSPSLSSHYSDSRSPSR-LSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSP 311
Query: 186 QRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTA 239
QR G S S S + +PSS + R + AA+AP+P A
Sbjct: 312 QRNGGSGQRS-------GAHGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPA 358
>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
Length = 538
Score = 41.2 bits (95), Expect = 0.002
Identities = 39/159 (24%), Positives = 65/159 (40%), Gaps = 22/159 (13%)
Query: 97 GATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTV 156
GA RP + R GG GGA + +G+ +G L E+++ A+G ++ +
Sbjct: 244 GAARPVSLREVVRY-----LGGSGGAGGRLTRGRVQG------LLEEEAAARGRLERTRL 292
Query: 157 GQS--DHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLN 214
G G RPS + R +R D+++EDEE++ S S++
Sbjct: 293 GALALPRGDRPGRAPPAASARPS-RSKRGGEERVLEKEEEEDDDEDEDEEDDVSEGSEVP 351
Query: 215 SNTRPSSATSR--------KSVREAASAPSPTAPEQPVD 245
+ RP+ A +S +E +P P Q D
Sbjct: 352 ESDRPAGAQHHQLNGERGPQSAKERVKEWTPCGPHQGQD 390
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 41.2 bits (95), Expect = 0.002
Identities = 34/126 (26%), Positives = 58/126 (46%), Gaps = 9/126 (7%)
Query: 23 RQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTS 82
+++K D++R ++K R+ L + + PR+R + + + SS STS
Sbjct: 414 KKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTS 473
Query: 83 YQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAE 142
+ + A S G T P P S + T TA +G RKE+ + +GP E
Sbjct: 474 WH-RPASPCPSPGPGHTLPPKPPSPRGT----TASPKGRVRRKEEAKESPSAAGP----E 524
Query: 143 DKSEAQ 148
DKS+++
Sbjct: 525 DKSQSK 530
>gi|61742808 hypothetical protein LOC283638 isoform 2 [Homo sapiens]
Length = 1484
Score = 40.8 bits (94), Expect = 0.003
Identities = 60/245 (24%), Positives = 96/245 (39%), Gaps = 39/245 (15%)
Query: 23 RQQKLDRQRALLEQKQKKKRQEPLMVQANADG-RPRSRRARQSEEQAPLVESYLSSSGST 81
R+Q +RQ L R EP+ A G RPR SEE+ P++ ++L SS
Sbjct: 934 REQSSERQHHPLGPTDMG-RGEPVRRSAIRRGHRPRGSLDWPSEERGPVL-AHLPSSDVM 991
Query: 82 SYQVQEADSLASVQLGATR-PTAPASAKRTKAAATAGGQGGAARKEK-KGKHKGTSGPAA 139
+ + ++ + +LG+ R P AP + AAR+E+ + GP A
Sbjct: 992 ASNHETPEATGAGRLGSRRKPAAPPPSP-------------AAREEQSRSSASSQKGPQA 1038
Query: 140 LAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGER-----------PSGQDLRA----- 183
L S + + + DA +T A GER P+ + +
Sbjct: 1039 LTRSNSLSTPRPTRASRLRRARLGDASDTEAADGERGSLGNPEPVGRPAAEQAKKLSRLD 1098
Query: 184 --TMQRKGISSSMSFDEDEEDEEENSSSSSQLN---SNTRPSSATSRKSVREAASAPSPT 238
M RK S + E S S + ++ +P+ A +R R+AA+ + T
Sbjct: 1099 ILAMPRKRAGSFTGTSDPEAAPARTSFSGRSVELCCASRKPTMAEARAVSRKAANTATTT 1158
Query: 239 APEQP 243
P QP
Sbjct: 1159 GPRQP 1163
>gi|163644261 hypothetical protein LOC283638 isoform 1 [Homo sapiens]
Length = 1554
Score = 40.8 bits (94), Expect = 0.003
Identities = 60/245 (24%), Positives = 96/245 (39%), Gaps = 39/245 (15%)
Query: 23 RQQKLDRQRALLEQKQKKKRQEPLMVQANADG-RPRSRRARQSEEQAPLVESYLSSSGST 81
R+Q +RQ L R EP+ A G RPR SEE+ P++ ++L SS
Sbjct: 1004 REQSSERQHHPLGPTDMG-RGEPVRRSAIRRGHRPRGSLDWPSEERGPVL-AHLPSSDVM 1061
Query: 82 SYQVQEADSLASVQLGATR-PTAPASAKRTKAAATAGGQGGAARKEK-KGKHKGTSGPAA 139
+ + ++ + +LG+ R P AP + AAR+E+ + GP A
Sbjct: 1062 ASNHETPEATGAGRLGSRRKPAAPPPSP-------------AAREEQSRSSASSQKGPQA 1108
Query: 140 LAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGER-----------PSGQDLRA----- 183
L S + + + DA +T A GER P+ + +
Sbjct: 1109 LTRSNSLSTPRPTRASRLRRARLGDASDTEAADGERGSLGNPEPVGRPAAEQAKKLSRLD 1168
Query: 184 --TMQRKGISSSMSFDEDEEDEEENSSSSSQLN---SNTRPSSATSRKSVREAASAPSPT 238
M RK S + E S S + ++ +P+ A +R R+AA+ + T
Sbjct: 1169 ILAMPRKRAGSFTGTSDPEAAPARTSFSGRSVELCCASRKPTMAEARAVSRKAANTATTT 1228
Query: 239 APEQP 243
P QP
Sbjct: 1229 GPRQP 1233
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 40.4 bits (93), Expect = 0.004
Identities = 48/235 (20%), Positives = 82/235 (34%), Gaps = 34/235 (14%)
Query: 11 PYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPL 70
PYS++ R+ R ++K+KKK+ R R+SE +P
Sbjct: 170 PYSLV-------RESSSSRSPTPKQKKKKKKKD----------------RGRRSESSSPR 206
Query: 71 VESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGK 130
E SS E+ R P S +++K + + +
Sbjct: 207 RERKKSSKKKKHRSESESKKRKH------RSPTPKSKRKSKDKKRKRSRSTTPAPKSRRA 260
Query: 131 HKGTSGPAALAEDKSEAQ---GPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQR 187
H+ TS +A + D S ++ + T + + G G+ P + + QR
Sbjct: 261 HRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQR 320
Query: 188 KGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQ 242
SS + + E+ + S TRPS + R S AP+P E+
Sbjct: 321 P--SSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAER 373
Score = 39.7 bits (91), Expect = 0.007
Identities = 33/165 (20%), Positives = 68/165 (41%), Gaps = 19/165 (11%)
Query: 86 QEADSLASVQLGATR------PTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAA 139
Q+ +LA++Q R ++ +S+ + +++++ G++ + +G A
Sbjct: 2516 QQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVA 2575
Query: 140 LAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDED 199
L S P + + G+ P+ + R++ SSS S
Sbjct: 2576 LKRVPSPTPAPKEAVREGRPPEPT------------PAKRKRRSSSSSSSSSSSSSSSSS 2623
Query: 200 EEDEEENSSSSSQLNSNTRPSSATSRKSVREAASA-PSPTAPEQP 243
+SSSSS +S++ SS++S + A P P +P++P
Sbjct: 2624 SSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKP 2668
Score = 38.5 bits (88), Expect = 0.015
Identities = 33/149 (22%), Positives = 59/149 (39%), Gaps = 2/149 (1%)
Query: 97 GATRPTAPASAKRTKA--AATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQIL 154
GA +P+A A+ + K ++++ ++ +S + + D + PVQ
Sbjct: 2514 GAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPE 2573
Query: 155 TVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLN 214
+ + A RP +R SSS S +SSSSS +
Sbjct: 2574 VALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSS 2633
Query: 215 SNTRPSSATSRKSVREAASAPSPTAPEQP 243
S++ SS++S S + + P P A +P
Sbjct: 2634 SSSSSSSSSSSSSSSPSPAKPGPQALPKP 2662
Score = 30.0 bits (66), Expect = 5.2
Identities = 49/218 (22%), Positives = 81/218 (37%), Gaps = 31/218 (14%)
Query: 45 PLMVQANADGRPRS-RRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTA 103
PL+ +A + P + ++R + E+AP S + + S S D Q + P+A
Sbjct: 2400 PLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQD-----QPRSPVPSA 2454
Query: 104 PASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQ 163
+ R A T G + +SG A + + + H+
Sbjct: 2455 FSDQSRCLIAQTTPVAGSQSL---------SSGAVATTTSSAGDHNGMLSVPAPGVPHSD 2505
Query: 164 DAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSAT 223
A+ G ++PS L A K E +SSSSS +S++ SS++
Sbjct: 2506 VGEPPASTGAQQPSA--LAALQPAK--------------ERRSSSSSSSSSSSSSSSSSS 2549
Query: 224 SRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQ 261
S S +S+ PV EV + PAP+
Sbjct: 2550 SSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPK 2587
>gi|21361684 G patch domain containing 1 [Homo sapiens]
Length = 931
Score = 39.7 bits (91), Expect = 0.007
Identities = 44/180 (24%), Positives = 75/180 (41%), Gaps = 17/180 (9%)
Query: 98 ATRPTAPASAKRTKAAATAGGQGGAARKE-KKGKHKGTSGPAALAEDKSEAQGPVQI--- 153
A+ PT AS+++ +R + K + K S L+ +S+A+ P Q
Sbjct: 657 ASLPTTQASSEKVSQHRGPDKSRKPSRWDTSKHEKKEDSISEFLSLARSKAEPPKQQSSP 716
Query: 154 LTVGQSDHA----------QDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDE 203
L + +HA +D A G G RPS RA S S ++++ D
Sbjct: 717 LVNKEEEHAPELSANQTVNKDVDAQAEGEGSRPSMDLFRAIFASSSDEKSSSSEDEQGDS 776
Query: 204 EENSSSSSQLN-SNTRPSSATSRKSVREA-ASAPSPTAPEQPVD-VEVQDLEEFALRPAP 260
E++ + S + N +++ + SV A AP P P+ +++ + EEF R P
Sbjct: 777 EDDQAGSGEANFQSSQDTDLGETSSVAHALVPAPQEPPPSFPIQKMQIDEREEFGPRLPP 836
>gi|21396500 HIRA interacting protein 3 [Homo sapiens]
Length = 556
Score = 39.3 bits (90), Expect = 0.009
Identities = 46/227 (20%), Positives = 85/227 (37%), Gaps = 45/227 (19%)
Query: 16 DDEGRNLRQQKLDRQRALLEQ-KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESY 74
+ E L Q+K R+ + E+ K++ + + + ++GR +S R +S +Q +
Sbjct: 226 ESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRL 285
Query: 75 LSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGT 134
L S S Q K AA++G G R+ +
Sbjct: 286 LGDSDSEEEQ--------------------------KEAASSGDDSGRDREPPVQRK--- 316
Query: 135 SGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSM 194
+ED+++ +G ++ + + GE A G + M R G +S
Sbjct: 317 ------SEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRK---------MARLGSTSGE 361
Query: 195 SFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPE 241
D + E + + Q R S +SRK ++S+ S +PE
Sbjct: 362 ESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPE 408
Score = 34.7 bits (78), Expect = 0.21
Identities = 38/189 (20%), Positives = 76/189 (40%), Gaps = 10/189 (5%)
Query: 36 QKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVES-YLSSSGSTSYQVQEADSLASV 94
+++ +R + +++ + R R A++ EE + E Y + ++A ASV
Sbjct: 128 KEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASV 187
Query: 95 QLGATRPTAPAS----AKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGP 150
R + S +RT A G +G + KE + + S LA+ K + +
Sbjct: 188 SRKQAREESEESEAEPVQRT-AKKVEGNKGTKSLKESEQE----SEEEILAQKKEQREEE 242
Query: 151 VQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSS 210
V+ + + D G R S ++ R+ Q+ + + EE+++E +SS
Sbjct: 243 VEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSG 302
Query: 211 SQLNSNTRP 219
+ P
Sbjct: 303 DDSGRDREP 311
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 38.9 bits (89), Expect = 0.011
Identities = 40/212 (18%), Positives = 85/212 (40%), Gaps = 20/212 (9%)
Query: 20 RNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLS-SS 78
R + ++ R+R LEQ ++K+ +E M + + R + R R++EE+ E+ S+
Sbjct: 142 REMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSA 201
Query: 79 GSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPA 138
+ + +D + + + P P G G KE+K + +
Sbjct: 202 HHRTMREDYSDKVKASHWSRSPPRPPRERFEL-------GDGRKPVKEEKMEERD----- 249
Query: 139 ALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDE 198
L D + + + +S A+ +G G ++ + S +E
Sbjct: 250 -LLSDLQDISDSERKTSSAESSSAE------SGSGSEEEEEEEEEEEEEGSTSEESEEEE 302
Query: 199 DEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 230
+EE+EEE + S+ ++ + + S + + E
Sbjct: 303 EEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 334
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 38.9 bits (89), Expect = 0.011
Identities = 40/212 (18%), Positives = 85/212 (40%), Gaps = 20/212 (9%)
Query: 20 RNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLS-SS 78
R + ++ R+R LEQ ++K+ +E M + + R + R R++EE+ E+ S+
Sbjct: 152 REMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSA 211
Query: 79 GSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPA 138
+ + +D + + + P P G G KE+K + +
Sbjct: 212 HHRTMREDYSDKVKASHWSRSPPRPPRERFEL-------GDGRKPVKEEKMEERD----- 259
Query: 139 ALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDE 198
L D + + + +S A+ +G G ++ + S +E
Sbjct: 260 -LLSDLQDISDSERKTSSAESSSAE------SGSGSEEEEEEEEEEEEEGSTSEESEEEE 312
Query: 199 DEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 230
+EE+EEE + S+ ++ + + S + + E
Sbjct: 313 EEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 344
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 38.9 bits (89), Expect = 0.011
Identities = 40/212 (18%), Positives = 85/212 (40%), Gaps = 20/212 (9%)
Query: 20 RNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLS-SS 78
R + ++ R+R LEQ ++K+ +E M + + R + R R++EE+ E+ S+
Sbjct: 143 REMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSA 202
Query: 79 GSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPA 138
+ + +D + + + P P G G KE+K + +
Sbjct: 203 HHRTMREDYSDKVKASHWSRSPPRPPRERFEL-------GDGRKPVKEEKMEERD----- 250
Query: 139 ALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDE 198
L D + + + +S A+ +G G ++ + S +E
Sbjct: 251 -LLSDLQDISDSERKTSSAESSSAE------SGSGSEEEEEEEEEEEEEGSTSEESEEEE 303
Query: 199 DEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 230
+EE+EEE + S+ ++ + + S + + E
Sbjct: 304 EEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 335
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.126 0.353
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,444,996
Number of Sequences: 37866
Number of extensions: 914729
Number of successful extensions: 8663
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 398
Number of HSP's that attempted gapping in prelim test: 7107
Number of HSP's gapped (non-prelim): 1521
length of query: 506
length of database: 18,247,518
effective HSP length: 107
effective length of query: 399
effective length of database: 14,195,856
effective search space: 5664146544
effective search space used: 5664146544
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.