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Search of human proteins with 29294647
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29294647 eukaryotic translation initiation factor 2C, 3
isoform a [Homo sapiens]
(860 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29294647 eukaryotic translation initiation factor 2C, 3 isofo... 1764 0.0
gi|6912352 eukaryotic translation initiation factor 2C, 1 [Homo ... 1501 0.0
gi|29029593 eukaryotic translation initiation factor 2C, 4 [Homo... 1436 0.0
gi|29171734 eukaryotic translation initiation factor 2C, 2 [Homo... 1419 0.0
gi|29337286 eukaryotic translation initiation factor 2C, 3 isofo... 1283 0.0
gi|221316711 piwi-like 4 [Homo sapiens] 165 2e-40
gi|66346725 piwi-like 1 [Homo sapiens] 163 7e-40
gi|209180418 piwi-like 2 [Homo sapiens] 147 4e-35
gi|24431985 piwi-like 2 [Homo sapiens] 147 4e-35
gi|153792298 piwi-like 3 [Homo sapiens] 144 3e-34
gi|169217928 PREDICTED: similar to piwi like homolog 2 [Homo sap... 50 1e-05
gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens] 34 0.66
gi|114199473 vacuolar protein sorting 41 isoform 2 [Homo sapiens] 34 0.66
gi|114199475 vacuolar protein sorting 41 isoform 1 [Homo sapiens] 34 0.66
gi|188536004 zinc finger protein 469 [Homo sapiens] 31 5.6
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 31 5.6
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens] 30 9.6
gi|39812019 amino-terminal enhancer of split isoform a [Homo sap... 30 9.6
>gi|29294647 eukaryotic translation initiation factor 2C, 3 isoform
a [Homo sapiens]
Length = 860
Score = 1764 bits (4568), Expect = 0.0
Identities = 860/860 (100%), Positives = 860/860 (100%)
Query: 1 MEIGSAGPAGAQPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPR 60
MEIGSAGPAGAQPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPR
Sbjct: 1 MEIGSAGPAGAQPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPR 60
Query: 61 RVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRP 120
RVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRP
Sbjct: 61 RVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRP 120
Query: 121 FKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGR 180
FKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGR
Sbjct: 121 FKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGR 180
Query: 181 SFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLD 240
SFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLD
Sbjct: 181 SFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLD 240
Query: 241 IHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLE 300
IHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLE
Sbjct: 241 IHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLE 300
Query: 301 NGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDN 360
NGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDN
Sbjct: 301 NGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDN 360
Query: 361 QTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQ 420
QTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQ
Sbjct: 361 QTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQ 420
Query: 421 YGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISK 480
YGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISK
Sbjct: 421 YGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISK 480
Query: 481 DAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTL 540
DAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTL
Sbjct: 481 DAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTL 540
Query: 541 LGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVT 600
LGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVT
Sbjct: 541 LGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVT 600
Query: 601 HPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRF 660
HPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRF
Sbjct: 601 HPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRF 660
Query: 661 KPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCAD 720
KPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCAD
Sbjct: 661 KPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCAD 720
Query: 721 RTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADEL 780
RTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADEL
Sbjct: 721 RTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADEL 780
Query: 781 QLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDP 840
QLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDP
Sbjct: 781 QLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDP 840
Query: 841 QALAKAVQIHQDTLRTMYFA 860
QALAKAVQIHQDTLRTMYFA
Sbjct: 841 QALAKAVQIHQDTLRTMYFA 860
>gi|6912352 eukaryotic translation initiation factor 2C, 1 [Homo
sapiens]
Length = 857
Score = 1501 bits (3887), Expect = 0.0
Identities = 726/864 (84%), Positives = 786/864 (90%), Gaps = 18/864 (2%)
Query: 6 AGPAGA---------QPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPD 56
AGP+GA Q + PRRPG GT+GKPIKLLAN F+V+IPKIDVY YEVDIKPD
Sbjct: 3 AGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPD 62
Query: 57 KCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGG 116
KCPRRVNREVV+ MVQHFK IFGDR+PVYDGK+++YT LP+ VD +VT+PGEG
Sbjct: 63 KCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEG- 121
Query: 117 KDRPFKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYT 176
KDR FKVSIK+++ VSW +LHE L +P PLE V A+DV +RHL SM+YT
Sbjct: 122 KDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLE--------SVQALDVAMRHLASMRYT 173
Query: 177 PVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMC 236
PVGRSFFS PEGY HPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVI+FMC
Sbjct: 174 PVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMC 233
Query: 237 EVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFP 296
EVLDI NIDEQP+PLTDS RV+FTKEIKGLKVEVTHCG M+RKYRVCNVTRRPASHQTFP
Sbjct: 234 EVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFP 293
Query: 297 LQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKK 356
LQLE+GQTVE TVAQYF++KY LQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKK
Sbjct: 294 LQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKK 353
Query: 357 LTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPA 416
LTDNQTSTMIKATARSAPDRQEEISRL+++A+Y DP++QEF KV+D+M VTGRVLPA
Sbjct: 354 LTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPA 413
Query: 417 PMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLR 476
P+LQYGGRNR +ATP+ GVWDMRGKQF+ G+EIK+WAIACFA Q+QCREE+LK FTDQLR
Sbjct: 414 PILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLR 473
Query: 477 KISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRV 536
KISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRV
Sbjct: 474 KISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRV 533
Query: 537 GDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLG 596
GDTLLGMATQCVQVKNV+KTSPQTLSNLCLKINVKLGGINNILVPHQR +VFQQPVIFLG
Sbjct: 534 GDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLG 593
Query: 597 ADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYK 656
ADVTHPPAGDGKKPSI AVVGSMDAHPSRYCATVRVQRPRQEII+DL+ MVRELLIQFYK
Sbjct: 594 ADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYK 653
Query: 657 STRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRL 716
STRFKPTRIIFYRDGV EGQ Q+L+YELLAIR+ACI LEKDYQPGITYIVVQKRHHTRL
Sbjct: 654 STRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRL 713
Query: 717 FCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFT 776
FCAD+ ER+G+SGNIPAGTTVDT+ITHP+EFDFYLCSHAGIQGTSRPSHY+VLWDDN FT
Sbjct: 714 FCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFT 773
Query: 777 ADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSN 836
ADELQ+LTYQLCHTYVRCTRSVSIPAPAYYA LVAFRARYHLVDKEHDS EGSH+SGQSN
Sbjct: 774 ADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSN 833
Query: 837 GRDPQALAKAVQIHQDTLRTMYFA 860
GRDPQALAKAVQ+HQDTLRTMYFA
Sbjct: 834 GRDPQALAKAVQVHQDTLRTMYFA 857
>gi|29029593 eukaryotic translation initiation factor 2C, 4 [Homo
sapiens]
Length = 861
Score = 1436 bits (3716), Expect = 0.0
Identities = 703/866 (81%), Positives = 770/866 (88%), Gaps = 21/866 (2%)
Query: 7 GPAGAQPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNREV 66
GP L PRRPG GT+GKPI+LLAN FQV+IPKIDVY Y+VDIKP+K PRRVNREV
Sbjct: 5 GPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREV 64
Query: 67 VDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSIK 126
VD+MV+HFK+ IFGDR+P YDGKR++YTA+PLP+ VD++VTLPGEG KD+ FKVS++
Sbjct: 65 VDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEG-KDQTFKVSVQ 123
Query: 127 FVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAP 186
+VS VS LL E L G P + V A+DV+ RHLPSM+YTPVGRSFFS P
Sbjct: 124 WVSVVSLQLLLEALAGHLNEVP--------DDSVQALDVITRHLPSMRYTPVGRSFFSPP 175
Query: 187 EGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDE 246
EGY HPLGGGREVWFGFHQSVRPAMW MMLNIDVSATAFY+AQP+I+FMCEVLDI NI+E
Sbjct: 176 EGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINE 235
Query: 247 QPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVE 306
Q +PLTDS RVKFTKEI+GLKVEVTHCG M+RKYRVCNVTRRPASHQTFPLQLENGQ +E
Sbjct: 236 QTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAME 295
Query: 307 RTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMI 366
TVAQYF++KY+LQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMI
Sbjct: 296 CTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMI 355
Query: 367 KATARSAPDRQEEISRLVRSANYE--TDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGR 424
KATARSAPDRQEEISRLV+S + DP+++EF V +EM +TGRVLPAPMLQYGGR
Sbjct: 356 KATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGR 415
Query: 425 NRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGM 484
N+TVATP+ GVWDMRGKQF+ G+EIK+WA+ACFA Q+QCRE++LK FTDQLRKISKDAGM
Sbjct: 416 NKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGM 475
Query: 485 PIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMA 544
PIQGQPCFCKYAQGADSVEPMF+HLK TY GLQLI+VILPGKTPVYAEVKRVGDTLLGMA
Sbjct: 476 PIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMA 535
Query: 545 TQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPA 604
TQCVQVKNV+KTSPQTLSNLCLKIN KLGGINN+LVPHQRPSVFQQPVIFLGADVTHPPA
Sbjct: 536 TQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPA 595
Query: 605 GDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEI----------IQDLASMVRELLIQF 654
GDGKKPSIAAVVGSMD HPSRYCATVRVQ RQEI IQDL +MVRELLIQF
Sbjct: 596 GDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQF 655
Query: 655 YKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHT 714
YKSTRFKPTRII+YR GVSEGQ +QV + EL+AIR+ACISLE+DY+PGITYIVVQKRHHT
Sbjct: 656 YKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHT 715
Query: 715 RLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNC 774
RLFCAD+TERVG+SGN+PAGTTVD+ ITHP EFDFYLCSHAGIQGTSRPSHY VLWDDNC
Sbjct: 716 RLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNC 775
Query: 775 FTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQ 834
FTADELQLLTYQLCHTYVRCTRSVSIPAPAYYA LVAFRARYHLVDK+HDSAEGSHVSGQ
Sbjct: 776 FTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQ 835
Query: 835 SNGRDPQALAKAVQIHQDTLRTMYFA 860
SNGRDPQALAKAVQIH DT TMYFA
Sbjct: 836 SNGRDPQALAKAVQIHHDTQHTMYFA 861
>gi|29171734 eukaryotic translation initiation factor 2C, 2 [Homo
sapiens]
Length = 859
Score = 1419 bits (3672), Expect = 0.0
Identities = 689/864 (79%), Positives = 768/864 (88%), Gaps = 18/864 (2%)
Query: 6 AGPAGAQPL---------LMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPD 56
AGPA A P P RP +GT G+ IKL AN F+++IPKID+Y YE+DIKP+
Sbjct: 5 AGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPE 64
Query: 57 KCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGG 116
KCPRRVNRE+V+ MVQHFK IFGDR+PV+DG+++LYTA PLP+ V+L+VTLPGEG
Sbjct: 65 KCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEG- 123
Query: 117 KDRPFKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYT 176
KDR FKVSIK+VS VS LH+ L+GR P E + A+DVV+RHLPSM+YT
Sbjct: 124 KDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFET--------IQALDVVMRHLPSMRYT 175
Query: 177 PVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMC 236
PVGRSFF+A EG +PLGGGREVWFGFHQSVRP++WKMMLNIDVSATAFYKAQPVI+F+C
Sbjct: 176 PVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVC 235
Query: 237 EVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFP 296
EVLD +I+EQ +PLTDS RVKFTKEIKGLKVE+THCG M+RKYRVCNVTRRPASHQTFP
Sbjct: 236 EVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFP 295
Query: 297 LQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKK 356
LQ E+GQTVE TVAQYF++++ L L+YPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKK
Sbjct: 296 LQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKK 355
Query: 357 LTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPA 416
LTDNQTSTMI+ATARSAPDRQEEIS+L+RSA++ TDP+V+EF V+DEM VTGRVL
Sbjct: 356 LTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQP 415
Query: 417 PMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLR 476
P + YGGRN+ +ATP GVWDMR KQFHTG+EIK+WAIACFA QRQC E LK FT+QLR
Sbjct: 416 PSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLR 475
Query: 477 KISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRV 536
KIS+DAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTY+GLQL++VILPGKTPVYAEVKRV
Sbjct: 476 KISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRV 535
Query: 537 GDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLG 596
GDT+LGMATQCVQ+KNV +T+PQTLSNLCLKINVKLGG+NNIL+P RP VFQQPVIFLG
Sbjct: 536 GDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLG 595
Query: 597 ADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYK 656
ADVTHPPAGDGKKPSIAAVVGSMDAHP+RYCATVRVQ+ RQEIIQDLA+MVRELLIQFYK
Sbjct: 596 ADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYK 655
Query: 657 STRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRL 716
STRFKPTRIIFYRDGVSEGQF+QVL++ELLAIREACI LEKDYQPGIT+IVVQKRHHTRL
Sbjct: 656 STRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRL 715
Query: 717 FCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFT 776
FC D+ ERVG+SGNIPAGTTVDT ITHP EFDFYLCSHAGIQGTSRPSHYHVLWDDN F+
Sbjct: 716 FCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFS 775
Query: 777 ADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSN 836
+DELQ+LTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSH SGQSN
Sbjct: 776 SDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSN 835
Query: 837 GRDPQALAKAVQIHQDTLRTMYFA 860
GRD QALAKAVQ+HQDTLRTMYFA
Sbjct: 836 GRDHQALAKAVQVHQDTLRTMYFA 859
>gi|29337286 eukaryotic translation initiation factor 2C, 3 isoform
b [Homo sapiens]
Length = 626
Score = 1283 bits (3320), Expect = 0.0
Identities = 626/626 (100%), Positives = 626/626 (100%)
Query: 235 MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQT 294
MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQT
Sbjct: 1 MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQT 60
Query: 295 FPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCI 354
FPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCI
Sbjct: 61 FPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCI 120
Query: 355 KKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVL 414
KKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVL
Sbjct: 121 KKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVL 180
Query: 415 PAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQ 474
PAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQ
Sbjct: 181 PAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQ 240
Query: 475 LRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVK 534
LRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVK
Sbjct: 241 LRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVK 300
Query: 535 RVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIF 594
RVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIF
Sbjct: 301 RVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIF 360
Query: 595 LGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQF 654
LGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQF
Sbjct: 361 LGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQF 420
Query: 655 YKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHT 714
YKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHT
Sbjct: 421 YKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHT 480
Query: 715 RLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNC 774
RLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNC
Sbjct: 481 RLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNC 540
Query: 775 FTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQ 834
FTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQ
Sbjct: 541 FTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQ 600
Query: 835 SNGRDPQALAKAVQIHQDTLRTMYFA 860
SNGRDPQALAKAVQIHQDTLRTMYFA
Sbjct: 601 SNGRDPQALAKAVQIHQDTLRTMYFA 626
>gi|221316711 piwi-like 4 [Homo sapiens]
Length = 852
Score = 165 bits (417), Expect = 2e-40
Identities = 184/808 (22%), Positives = 344/808 (42%), Gaps = 95/808 (11%)
Query: 24 GTMGKPIKLLANCFQVEIPKI-DVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDR 82
G+ G P+KL+ N F ++ P+ +Y Y V PD RR+ + + H +++ ++
Sbjct: 100 GSSGIPVKLVTNLFNLDFPQDWQLYQYHVTYIPDLASRRLR---IALLYSHSELS---NK 153
Query: 83 RPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSIKFVSRVSWHLLHEVLTG 142
+DG L+ + L T L E + K++I
Sbjct: 154 AKAFDGA-ILFLSQKLEEKVT------ELSSETQRGETIKMTI----------------- 189
Query: 143 RTLPEPLELDKPISTNPVHAVDVVLRH-LPSMKYTPVGRSFFSAPEGYDHPLGGGREVWF 201
TL L P+ + +++ R L + +GR+F++ E + P +W
Sbjct: 190 -TLKRELPSSSPVC---IQVFNIIFRKILKKLSMYQIGRNFYNPSEPMEIPQHK-LSLWP 244
Query: 202 GFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTK 261
GF SV K++ + DVS + + V++FM + R K
Sbjct: 245 GFAISVSYFERKLLFSADVSYKVL-RNETVLEFMTALCQ--------RTGLSCFTQTCEK 295
Query: 262 EIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQL 321
++ GL V + R Y + ++ TF Q +G E T Y++++Y + +
Sbjct: 296 QLIGLIVLTRY---NNRTYSIDDIDWSVKPTHTF--QKRDG--TEITYVDYYKQQYDITV 348
Query: 322 KYPHLPCL-QVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTST--MIKATAR----SAP 374
+ P L + +++++ ++ +++ + LTD TS ++KA A S
Sbjct: 349 SDLNQPMLVSLLKKKRNDNSEAQLAHLIPELCFLTGLTDQATSDFQLMKAVAEKTRLSPS 408
Query: 375 DRQEEISRLV------RSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTV 428
RQ+ ++RLV +A +E + + F ++ +TGR++P+ +
Sbjct: 409 GRQQRLARLVDNIQRNTNARFELETWGLHFGSQIS-----LTGRIVPSEKILMQDHICQP 463
Query: 429 ATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQG 488
+ + D+R + + W I C E + + F + LR+++ G +
Sbjct: 464 VSAADWSKDIRTCKILNAQSLNTWLILC----SDRTEYVAESFLNCLRRVAGSMGFNVDY 519
Query: 489 QPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAE-VKRVGDTLLGMATQC 547
A V + +++ +QL++ ILP Y + +K+ + + +QC
Sbjct: 520 PKIIKVQENPAAFVRAIQQYVD---PDVQLVMCILPSNQKTYYDSIKKYLSSDCPVPSQC 576
Query: 548 VQVKNVIKTSPQT--LSNLCLKINVKLGG-INNILVPHQRPSVFQQPVIFLGADVTHPPA 604
V + + K + + +++ KLGG + + +P + ++ +G DV
Sbjct: 577 VLARTLNKQGMMMSIATKIAMQMTCKLGGELWAVEIP-------LKSLMVVGIDVCKDAL 629
Query: 605 GDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTR 664
K + V S++ +R+ + +QR ++ L + L ++YK P R
Sbjct: 630 S--KDVMVVGCVASVNPRITRWFSRCILQRTMTDVADCLKVFMTGALNKWYKYNHDLPAR 687
Query: 665 IIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTER 724
II YR GV +GQ + ++ YE+ + + + ++ IVV+K+ R F TE
Sbjct: 688 IIVYRAGVGDGQLKTLIEYEVPQLLSSVAESSSNTSSRLSVIVVRKKCMPRFF----TEM 743
Query: 725 VGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLT 784
N P GT VD++ T +DFYL S +GT P++Y+V++DDN D +Q LT
Sbjct: 744 NRTVQNPPLGTVVDSEATRNEWYDFYLISQVACRGTVSPTYYNVIYDDNGLKPDHMQRLT 803
Query: 785 YQLCHTYVRCTRSVSIPAPAYYAHLVAF 812
++LCH Y VS+PAP YAH + F
Sbjct: 804 FKLCHLYYNWPGIVSVPAPCQYAHKLTF 831
>gi|66346725 piwi-like 1 [Homo sapiens]
Length = 861
Score = 163 bits (412), Expect = 7e-40
Identities = 168/684 (24%), Positives = 290/684 (42%), Gaps = 71/684 (10%)
Query: 154 PISTNPVHAVDVVLRHLPS-MKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMW 212
P S + +++ R L M +GR++++ + D P +W GF S+
Sbjct: 203 PTSPTCLQFYNIIFRRLLKIMNLQQIGRNYYNPNDPIDIP-SHRLVIWPGFTTSILQYEN 261
Query: 213 KMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTH 272
+ML DVS +++ V+ FM H +E + + +KE+ GL V +
Sbjct: 262 SIMLCTDVSHKVL-RSETVLDFMFNFY--HQTEEH------KFQEQVSKELIGLVVLTKY 312
Query: 273 CGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVG 332
+ YRV ++ TF + E + +Y+R++Y ++ P L V
Sbjct: 313 ---NNKTYRVDDIDWDQNPKSTF----KKADGSEVSFLEYYRKQYNQEITDLKQPVL-VS 364
Query: 333 QEQKH----------TYLPLEVCNIVAGQRCIKKLTD------NQTSTMIKATARSAPDR 376
Q ++ L E+C + LTD N + T + R
Sbjct: 365 QPKRRRGPGGTLPGPAMLIPELCYLTG-------LTDKMRNDFNVMKDLAVHTRLTPEQR 417
Query: 377 QEEISRLVR--SANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHG 434
Q E+ RL+ N ++++ + +GR+L + GG+ P
Sbjct: 418 QREVGRLIDYIHKNDNVQRELRDWGLSFDSNLLSFSGRILQTEKIHQGGKTFDY-NPQFA 476
Query: 435 VW--DMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCF 492
W + RG + + W + T+R E L K++ GM ++
Sbjct: 477 DWSKETRGAPLISVKPLDNWLL--IYTRRNY--EAANSLIQNLFKVTPAMGMQMRKAIMI 532
Query: 493 CKYAQGADSVEPMFRHLKNTYSGLQLIIVIL--PGKTPVYAEVKRVGDTLLGMATQCVQV 550
+ D E R L+ + I+V L + Y +K+ T +QCV
Sbjct: 533 ----EVDDRTEAYLRVLQQKVTADTQIVVCLLSSNRKDKYDAIKKYLCTDCPTPSQCVVA 588
Query: 551 KNVIK--TSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGK 608
+ + K T + + L++N K+GG R + + V+ +G D H +
Sbjct: 589 RTLGKQQTVMAIATKIALQMNCKMGG------ELWRVDIPLKLVMIVGIDCYHDMTAGRR 642
Query: 609 KPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFY 668
SIA V S++ +R+ + Q QE++ L ++ L + + P+RII Y
Sbjct: 643 --SIAGFVASINEGMTRWFSRCIFQDRGQELVDGLKVCLQAALRAWNSCNEYMPSRIIVY 700
Query: 669 RDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRS 728
RDGV +GQ + ++ YE+ + S+ + Y P +T IVV+KR +TR F + GR
Sbjct: 701 RDGVGDGQLKTLVNYEVPQFLDCLKSIGRGYNPRLTVIVVKKRVNTRFFA----QSGGRL 756
Query: 729 GNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLC 788
N GT +D ++T P +DF++ S A G+ P+HY+V++D++ D +Q LTY+LC
Sbjct: 757 QNPLPGTVIDVEVTRPEWYDFFIVSQAVRSGSVSPTHYNVIYDNSGLKPDHIQRLTYKLC 816
Query: 789 HTYVRCTRSVSIPAPAYYAHLVAF 812
H Y + +PAP YAH +AF
Sbjct: 817 HIYYNWPGVIRVPAPCQYAHKLAF 840
>gi|209180418 piwi-like 2 [Homo sapiens]
Length = 973
Score = 147 bits (371), Expect = 4e-35
Identities = 164/659 (24%), Positives = 292/659 (44%), Gaps = 69/659 (10%)
Query: 178 VGRSFF---SAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQF 234
VGR+F+ SA H L ++W G+ S+R + L DVS VI+
Sbjct: 339 VGRNFYDPTSAMVLQQHRL----QIWPGYAASIRRTDGGLFLLADVS-------HKVIRN 387
Query: 235 MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQT 294
C + +H I +Q + + + + TK + G + +T R YR+ +V +
Sbjct: 388 DCVLDVMHAIYQQNK---EHFQDECTKLLVG-NIVITRYNN--RTYRIDDVDWNKTPKDS 441
Query: 295 FPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCL---------QVGQEQKHTYLPLEVC 345
F + +G+ + T +Y+ + Y + +K P L G K L L
Sbjct: 442 FTMS--DGKEI--TFLEYYSKNYGITVKEEDQPLLIHRPSERQDNHGMLLKGEILLLPEL 497
Query: 346 NIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVR--SANYETDPFVQEFQFKVR 403
+ + G K + + S + L++ + N + + +++
Sbjct: 498 SFMTGIPEKMKKDFRAMKDLAQQINLSPKQHHSALECLLQRIAKNEAATNELMRWGLRLQ 557
Query: 404 DEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQR-- 461
++ + GRVLP + +N + T W + + + I M A F +R
Sbjct: 558 KDVHKIEGRVLPMERINL--KNTSFITSQELNWVKEVTRDPSILTIPMHFWALFYPKRAM 615
Query: 462 -QCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSG---LQ 517
Q RE + + L KI+ GM + P + + D +E R +++T +Q
Sbjct: 616 DQARELV-----NMLEKIAGPIGMRMS-PPAWVELKD--DRIETYVRTIQSTLGAEGKIQ 667
Query: 518 LIIVILPG-KTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSP--QTLSNLCLKINVKLGG 574
+++ I+ G + +Y +K++ + +Q V V+ + + + + L+IN KLGG
Sbjct: 668 MVVCIIMGPRDDLYGAIKKLCCVQSPVPSQVVNVRTIGQPTRLRSVAQKILLQINCKLGG 727
Query: 575 -INNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQ 633
+ + +P ++ ++ +G DV H P+ + S+ V S++ +++ + V Q
Sbjct: 728 ELWGVDIPLKQ-------LMVIGMDVYHDPSRGMR--SVVGFVASINLTLTKWYSRVVFQ 778
Query: 634 RPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACI 693
P QEI+ L + L +FY+ P +I+ YRDGVS+GQ + V YE+ +++ C
Sbjct: 779 MPHQEIVDSLKLCLVGSLKKFYEVNHCLPEKIVVYRDGVSDGQLKTVANYEIPQLQK-CF 837
Query: 694 SLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCS 753
++YQP + VVQK+ T L+ A V + GT VD IT DFYL +
Sbjct: 838 EAFENYQPKMVVFVVQKKISTNLYLAAPQNFVTPT----PGTVVDHTITSCEWVDFYLLA 893
Query: 754 HAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAF 812
H QG P+HY + + + D +Q LT++LCH Y ++ +PAP YAH +AF
Sbjct: 894 HHVRQGCGIPTHYVCVLNTANLSPDHMQRLTFKLCHMYWNWPGTIRVPAPCKYAHKLAF 952
>gi|24431985 piwi-like 2 [Homo sapiens]
Length = 973
Score = 147 bits (371), Expect = 4e-35
Identities = 164/659 (24%), Positives = 292/659 (44%), Gaps = 69/659 (10%)
Query: 178 VGRSFF---SAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQF 234
VGR+F+ SA H L ++W G+ S+R + L DVS VI+
Sbjct: 339 VGRNFYDPTSAMVLQQHRL----QIWPGYAASIRRTDGGLFLLADVS-------HKVIRN 387
Query: 235 MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQT 294
C + +H I +Q + + + + TK + G + +T R YR+ +V +
Sbjct: 388 DCVLDVMHAIYQQNK---EHFQDECTKLLVG-NIVITRYNN--RTYRIDDVDWNKTPKDS 441
Query: 295 FPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCL---------QVGQEQKHTYLPLEVC 345
F + +G+ + T +Y+ + Y + +K P L G K L L
Sbjct: 442 FTMS--DGKEI--TFLEYYSKNYGITVKEEDQPLLIHRPSERQDNHGMLLKGEILLLPEL 497
Query: 346 NIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVR--SANYETDPFVQEFQFKVR 403
+ + G K + + S + L++ + N + + +++
Sbjct: 498 SFMTGIPEKMKKDFRAMKDLAQQINLSPKQHHSALECLLQRIAKNEAATNELMRWGLRLQ 557
Query: 404 DEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQR-- 461
++ + GRVLP + +N + T W + + + I M A F +R
Sbjct: 558 KDVHKIEGRVLPMERINL--KNTSFITSQELNWVKEVTRDPSILTIPMHFWALFYPKRAM 615
Query: 462 -QCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSG---LQ 517
Q RE + + L KI+ GM + P + + D +E R +++T +Q
Sbjct: 616 DQARELV-----NMLEKIAGPIGMRMS-PPAWVELKD--DRIETYVRTIQSTLGAEGKIQ 667
Query: 518 LIIVILPG-KTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSP--QTLSNLCLKINVKLGG 574
+++ I+ G + +Y +K++ + +Q V V+ + + + + L+IN KLGG
Sbjct: 668 MVVCIIMGPRDDLYGAIKKLCCVQSPVPSQVVNVRTIGQPTRLRSVAQKILLQINCKLGG 727
Query: 575 -INNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQ 633
+ + +P ++ ++ +G DV H P+ + S+ V S++ +++ + V Q
Sbjct: 728 ELWGVDIPLKQ-------LMVIGMDVYHDPSRGMR--SVVGFVASINLTLTKWYSRVVFQ 778
Query: 634 RPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACI 693
P QEI+ L + L +FY+ P +I+ YRDGVS+GQ + V YE+ +++ C
Sbjct: 779 MPHQEIVDSLKLCLVGSLKKFYEVNHCLPEKIVVYRDGVSDGQLKTVANYEIPQLQK-CF 837
Query: 694 SLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCS 753
++YQP + VVQK+ T L+ A V + GT VD IT DFYL +
Sbjct: 838 EAFENYQPKMVVFVVQKKISTNLYLAAPQNFVTPT----PGTVVDHTITSCEWVDFYLLA 893
Query: 754 HAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAF 812
H QG P+HY + + + D +Q LT++LCH Y ++ +PAP YAH +AF
Sbjct: 894 HHVRQGCGIPTHYVCVLNTANLSPDHMQRLTFKLCHMYWNWPGTIRVPAPCKYAHKLAF 952
>gi|153792298 piwi-like 3 [Homo sapiens]
Length = 882
Score = 144 bits (363), Expect = 3e-34
Identities = 190/824 (23%), Positives = 342/824 (41%), Gaps = 116/824 (14%)
Query: 24 GTMGKPIKLLANCFQV-EIPKIDVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDR 82
G+ G ++LLAN F+V P+ Y Y VD KPD + ++D QH + FG+R
Sbjct: 119 GSEGTVVQLLANHFRVISRPQWVAYKYNVDYKPDIEDGNLRTILLD---QHRRK--FGER 173
Query: 83 RPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSIKFVSRVSWHLLHEVLTG 142
++DG SL + PL K+R RV W L
Sbjct: 174 H-IFDGN-SLLLSRPL------------------KER----------RVEW--LSTTKDK 201
Query: 143 RTLPEPLELDK---PISTNPVHAVDVVLRH-LPSMKYTPVGRSFFSAPEG---YDHPLGG 195
+ +E K P S + + +++ R + + VGR++++ + Y H G
Sbjct: 202 NIVKITVEFSKELTPTSPDCLRYYNILFRRTFKLLDFEQVGRNYYTKKKAIQLYRH--GT 259
Query: 196 GREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSH 255
E+W G+ SV + L DVS + + F+ + T +
Sbjct: 260 SLEIWLGYVTSVLQYENSITLCADVSHKLL-RIETAYDFIKRT--------SAQAQTGNI 310
Query: 256 RVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFRE 315
R + T ++ G V + + YRV ++ + TF +G + T Y+R+
Sbjct: 311 REEVTNKLIGSIVLTKY---NNKTYRVDDIDWKQNPEDTF--NKSDGSKI--TYIDYYRQ 363
Query: 316 KYTLQLKYPHLPCLQ---------VGQEQKHTYLPLEVCNIVAGQRCIKKLTD------N 360
++ + P L G +++ L ++C++ LTD +
Sbjct: 364 QHKEIVTVKKQPLLVSQGRWKKGLTGTQREPILLIPQLCHMTG-------LTDEICKDYS 416
Query: 361 QTSTMIKATARSAPDRQEEISRLVRSA--NYETDPFVQEFQFKVRDEMAHVTGRVLPAPM 418
+ K T S R + + + N + +Q + K V GRVL
Sbjct: 417 IVKELAKHTRLSPRRRHHTLKEFINTLQDNKKVRELLQLWDLKFDTNFLSVPGRVLKNAN 476
Query: 419 LQYGGRNRTVATPSHGVW--DMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLR 476
+ G R V S G W ++R + + W I ++ LKG L+
Sbjct: 477 IVQG--RRMVKANSQGDWSREIRELPLLNAMPLHSWLIL-YSRSSHREAMSLKG---HLQ 530
Query: 477 KISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYS-GLQLIIV-----ILPGKTPV- 529
++ G+ ++ ++ + ++ + T G+ ++V ILP
Sbjct: 531 SVTAPMGITMKPAEMIEVDGDANSYIDTLRKYTRPTLQMGMSCLLVFKVICILPNDDKRR 590
Query: 530 YAEVKRVGDTLLGMATQCVQVKNVIKTSPQTL-SNLCLKINVKLGGINNILVPHQRPSVF 588
Y +KR T + +QCV K + K +T+ + + ++N K+GG +
Sbjct: 591 YDSIKRYLCTKCPIPSQCVVKKTLEKVQARTIVTKIAQQMNCKMGGAL------WKVETD 644
Query: 589 QQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVR 648
Q +F+G D H ++ SIA V S +A +++ + +Q+ +E++++L ++
Sbjct: 645 VQRTMFVGIDCFHDIVN--RQKSIAGFVASTNAELTKWYSQCVIQKTGEELVKELEICLK 702
Query: 649 ELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVV 708
L + K+ P +I YRDGV +GQ + +L +E + ++ + + +IVV
Sbjct: 703 AALDVWCKNESSMPHSVIVYRDGVGDGQLQALLDHEAKKMSTYLKTISPNNFT-LAFIVV 761
Query: 709 QKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHV 768
+KR +TR F + N P GT +D ++T +DF++ S + GT P+HY+V
Sbjct: 762 KKRINTRFFL----KHGSNFQNPPPGTVIDVELTRNEWYDFFIVSQSVQDGTVTPTHYNV 817
Query: 769 LWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAF 812
++D + D +Q LTY LCH Y + +PAP +YAH +A+
Sbjct: 818 IYDTIGLSPDTVQRLTYCLCHMYYNLPGIIRVPAPCHYAHKLAY 861
>gi|169217928 PREDICTED: similar to piwi like homolog 2 [Homo
sapiens]
Length = 349
Score = 49.7 bits (117), Expect = 1e-05
Identities = 60/269 (22%), Positives = 124/269 (46%), Gaps = 29/269 (10%)
Query: 401 KVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQ 460
+++ ++ + GRVLP + +N + T W + + + I M A F +
Sbjct: 49 RLQKDVHKIEGRVLPMERINL--KNTSFITSQELNWVKEVTRDPSILTIPMHFWALFYPK 106
Query: 461 R---QCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSG-- 515
R Q RE + + L KI+ GM + P + + D +E R +++T
Sbjct: 107 RAMDQARELV-----NMLEKIAGPIGMRMS-PPAWVELKD--DRIETYVRTIQSTLGAEG 158
Query: 516 -LQLIIVILPG-KTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSP--QTLSNLCLKINVK 571
+Q+++ I+ G + +Y +K++ + +Q V V+ + + + + L+IN K
Sbjct: 159 KIQMVVCIIMGPRDDLYGAIKKLCCVQSPVPSQVVNVRTIGQPTRLRSVAQKILLQINCK 218
Query: 572 LGG-INNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATV 630
LGG + + +P ++ ++ +G DV H P+ + S+ V S++ +++ + V
Sbjct: 219 LGGELWGVDIPLKQ-------LMVIGMDVYHDPSRGMR--SVVGFVASINLTLTKWYSRV 269
Query: 631 RVQRPRQEIIQDLASMVRELLIQFYKSTR 659
Q P QEI+ L + L +FY++ +
Sbjct: 270 VFQMPHQEIVDSLKLCLVGSLKKFYEAAQ 298
>gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens]
Length = 1088
Score = 33.9 bits (76), Expect = 0.66
Identities = 43/148 (29%), Positives = 56/148 (37%), Gaps = 32/148 (21%)
Query: 698 DYQPG------ITYIVVQKRHHTRLFCADRT---ERVGRSGNI-----PAGTTVDTDITH 743
DY PG + + V H R + A+ T E V + G I P +D D H
Sbjct: 746 DYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLD-GH 804
Query: 744 PYEFDFYLCSHAGIQGTSRPSHY----HV---------LWDD--NCFTADELQLLTYQLC 788
DF LC+ G + T +Y HV LWDD NC D L+ L +
Sbjct: 805 IKLTDFGLCT--GFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRAR 862
Query: 789 HTYVRCTRSVSIPAPAYYAHLVAFRARY 816
+ RC + P Y A V R Y
Sbjct: 863 KQHQRCLAHSLVGTPNYIAPEVLLRKGY 890
>gi|114199473 vacuolar protein sorting 41 isoform 2 [Homo sapiens]
Length = 829
Score = 33.9 bits (76), Expect = 0.66
Identities = 25/99 (25%), Positives = 48/99 (48%), Gaps = 9/99 (9%)
Query: 626 YCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYEL 685
YCA RPR +IIQ L+ E+ F+ Y SEG + L+Y +
Sbjct: 273 YCA-----RPRLDIIQPLSETCEEISSDALTVRGFQENECRDYHLEYSEG---ESLFY-I 323
Query: 686 LAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTER 724
++ R+ ++ E+D I +++ +K++ L A+ +++
Sbjct: 324 VSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQK 362
>gi|114199475 vacuolar protein sorting 41 isoform 1 [Homo sapiens]
Length = 854
Score = 33.9 bits (76), Expect = 0.66
Identities = 25/99 (25%), Positives = 48/99 (48%), Gaps = 9/99 (9%)
Query: 626 YCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYEL 685
YCA RPR +IIQ L+ E+ F+ Y SEG + L+Y +
Sbjct: 298 YCA-----RPRLDIIQPLSETCEEISSDALTVRGFQENECRDYHLEYSEG---ESLFY-I 348
Query: 686 LAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTER 724
++ R+ ++ E+D I +++ +K++ L A+ +++
Sbjct: 349 VSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQK 387
>gi|188536004 zinc finger protein 469 [Homo sapiens]
Length = 3925
Score = 30.8 bits (68), Expect = 5.6
Identities = 26/96 (27%), Positives = 40/96 (41%), Gaps = 6/96 (6%)
Query: 80 GDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSIKFVSRVS----WHL 135
G RRP G+++ LP V + + PG G P + S +S S HL
Sbjct: 3424 GVRRPGAPGQKARALEGTLPSKRRRVAMPGSAPGPGEDRPPPRGSSPILSEGSLPALLHL 3483
Query: 136 LHEVLTGRTLPEPLELDKPIS--TNPVHAVDVVLRH 169
EV T P L++P+ T+P+ ++ H
Sbjct: 3484 CSEVAPSTTKGWPETLERPVDPVTHPIRGCELPSNH 3519
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 30.8 bits (68), Expect = 5.6
Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 3/51 (5%)
Query: 446 GVEIKMWAIACFATQRQCREEILKGFT--DQLRKISKDAGMPIQGQ-PCFC 493
GV + MWA+ C + R L G + DQL +I + G P + Q P C
Sbjct: 191 GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241
>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
Length = 1318
Score = 30.0 bits (66), Expect = 9.6
Identities = 19/69 (27%), Positives = 29/69 (42%), Gaps = 11/69 (15%)
Query: 183 FSAPEGYDHPLGGG-----------REVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPV 231
F A Y++PLG G R +W G H + +P+ K ++ S Y
Sbjct: 530 FEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDA 589
Query: 232 IQFMCEVLD 240
+FM +LD
Sbjct: 590 QEFMAFLLD 598
>gi|39812019 amino-terminal enhancer of split isoform a [Homo
sapiens]
Length = 264
Score = 30.0 bits (66), Expect = 9.6
Identities = 45/160 (28%), Positives = 61/160 (38%), Gaps = 13/160 (8%)
Query: 702 GITYIVVQKRH-----HTRLFCADRTERVG--RSGNIPAGTTVDTDITHPYEFDFY-LCS 753
GIT +QKR + R A TE V R G AG T FD +
Sbjct: 12 GITAAFLQKRKLRLSKNHRPARAKVTEHVRGTRPGRATAGPAASTRAAGSLFFDRWGNRG 71
Query: 754 HAGIQGTSR-PSHYHVLWDDNCFTA-DELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVA 811
AG +G+S P D+C DE QLL Q + C + S + +++
Sbjct: 72 PAGCRGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMY 131
Query: 812 FRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQ 851
+ Y L + H AE + + NG Q L Q HQ
Sbjct: 132 YEMSYGLNIEMHKQAE---IVKRLNGICAQVLPYLSQEHQ 168
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,431,295
Number of Sequences: 37866
Number of extensions: 1623776
Number of successful extensions: 3133
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 3101
Number of HSP's gapped (non-prelim): 25
length of query: 860
length of database: 18,247,518
effective HSP length: 111
effective length of query: 749
effective length of database: 14,044,392
effective search space: 10519249608
effective search space used: 10519249608
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.