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Search of human proteins with 29171730
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29171730 cytochrome P450, family 20, subfamily A,
polypeptide 1 [Homo sapiens]
(462 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29171730 cytochrome P450, family 20, subfamily A, polypeptide... 921 0.0
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 83 5e-16
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 75 1e-13
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 75 2e-13
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 70 4e-12
gi|5729796 cytochrome P450, family 46 [Homo sapiens] 70 5e-12
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 69 7e-12
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ... 68 2e-11
gi|4503195 cytochrome P450, family 17 [Homo sapiens] 65 1e-10
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 65 2e-10
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ... 65 2e-10
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide... 63 5e-10
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ... 62 1e-09
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ... 61 2e-09
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ... 60 4e-09
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H... 60 4e-09
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H... 60 4e-09
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ... 59 7e-09
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ... 59 9e-09
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 58 2e-08
gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ... 57 4e-08
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ... 57 4e-08
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 57 4e-08
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 56 6e-08
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1... 55 2e-07
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide... 55 2e-07
gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II [... 54 2e-07
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ... 54 3e-07
gi|13904858 cytochrome P450, family 19 [Homo sapiens] 54 4e-07
gi|13904860 cytochrome P450, family 19 [Homo sapiens] 54 4e-07
>gi|29171730 cytochrome P450, family 20, subfamily A, polypeptide 1
[Homo sapiens]
Length = 462
Score = 921 bits (2381), Expect = 0.0
Identities = 462/462 (100%), Positives = 462/462 (100%)
Query: 1 MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVN 60
MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVN
Sbjct: 1 MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVN 60
Query: 61 LHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSEN 120
LHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSEN
Sbjct: 61 LHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSEN 120
Query: 121 HMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMV 180
HMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMV
Sbjct: 121 HMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMV 180
Query: 181 MGSTFEDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNMTRKKQYEDALMQLESVLRNIIK 240
MGSTFEDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNMTRKKQYEDALMQLESVLRNIIK
Sbjct: 181 MGSTFEDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNMTRKKQYEDALMQLESVLRNIIK 240
Query: 241 ERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQK 300
ERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQK
Sbjct: 241 ERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQK 300
Query: 301 KLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPR 360
KLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPR
Sbjct: 301 KLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPR 360
Query: 361 ETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLGFSGTQECPELRFAYMVTT 420
ETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLGFSGTQECPELRFAYMVTT
Sbjct: 361 ETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLGFSGTQECPELRFAYMVTT 420
Query: 421 VLLSVLVKRLHLLSVEGQVIETKYELVTSSREEAWITVSKRY 462
VLLSVLVKRLHLLSVEGQVIETKYELVTSSREEAWITVSKRY
Sbjct: 421 VLLSVLVKRLHLLSVEGQVIETKYELVTSSREEAWITVSKRY 462
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 83.2 bits (204), Expect = 5e-16
Identities = 109/456 (23%), Positives = 191/456 (41%), Gaps = 69/456 (15%)
Query: 12 LLALVGAVLYLYPASRQAA----GIPGITPTEEKDGNLPDIVNSGSLHE----FLVNLHE 63
LLA+ +LYLY GIPG TP LP + N S H+ F + H+
Sbjct: 14 LLAVSLVLLYLYGTHSHGLFKKLGIPGPTP-------LPFLGNILSYHKGFCMFDMECHK 66
Query: 64 RYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSENH-- 121
+YG V F+ G++ V+++ D++K + S + + S++E+
Sbjct: 67 KYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEW 126
Query: 122 --MRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPET-QHVPLSQHMLGFAMKSVTQ 178
+R L + LK ++ + + L+ ET + V L ++M +T
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
Query: 179 MVMGSTF-----------EDDQEVIRFQKNHGTVWSEIGKGFLDGSLD------------ 215
G E+ ++++RF S FL L+
Sbjct: 187 TSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVT 246
Query: 216 ----KNMTRKKQ--YEDALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILED 269
K++ R K+ ED L+ +I + + H L+D +++
Sbjct: 247 NFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESH--------KALSDLELVAQ 298
Query: 270 SMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN-GPVTPEKIEQLRYCQH 328
S+IF A T+ + ++ + L T +VQ+KL EEI+ V N P T + + Q+ Y
Sbjct: 299 SIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDM 358
Query: 329 VLCETVRTAKLTPVSAQLQDI---EGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFD 385
V+ ET+R L P++ +L+ + + +I+ IP+ +V+ + +DP W P KF
Sbjct: 359 VVNETLR---LFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFL 415
Query: 386 PDRFD----DELVMKTFSSLGFSGTQECPELRFAYM 417
P+RF D + ++ G SG + C +RFA M
Sbjct: 416 PERFSKKNKDNIDPYIYTPFG-SGPRNCIGMRFALM 450
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 75.1 bits (183), Expect = 1e-13
Identities = 107/446 (23%), Positives = 194/446 (43%), Gaps = 53/446 (11%)
Query: 12 LLALVGAVLYLYPASRQAA----GIPGITPTEEKDGNLPDIVNSGSLHE----FLVNLHE 63
LLA+ +LYLY GIPG TP LP + N+ S + F + ++
Sbjct: 14 LLAVSLILLYLYGTRTHGLFKKLGIPGPTP-------LPFLGNALSFRKGYWTFDMECYK 66
Query: 64 RYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSENH-- 121
+Y V + ++ ++++ D++K + S + + S++E+
Sbjct: 67 KYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEW 126
Query: 122 --MRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLG-FAMKSVTQ 178
+R L + LK ++ + + L+ ET +H+ G ++M +T
Sbjct: 127 KRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITS 186
Query: 179 MVMGSTF-----------EDDQEVIRFQKNHGTVWSEIGKGFLDGSLDK-NMT--RKKQY 224
G + E+ ++++RF V S FL L+ N+T +K
Sbjct: 187 TSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVI 246
Query: 225 EDALMQLESVLRNIIKE-RKGRNFSQHIFIDSLVQGN------LNDQQILEDSMIFSLAS 277
++ + +KE +K R + IDS + L+D +++ S+IF A
Sbjct: 247 SFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAG 306
Query: 278 CIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN-GPVTPEKIEQLRYCQHVLCETVRT 336
T+ + ++ I L T +VQ+K+ +EI+ V N P T + + QL Y V+ ET+R
Sbjct: 307 YETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLR- 365
Query: 337 AKLTPVSAQLQDI---EGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFD--- 390
L PV+ +L+ + + +I+ IP+ +V+ V+ DP W P KF P+RF
Sbjct: 366 --LFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKN 423
Query: 391 -DELVMKTFSSLGFSGTQECPELRFA 415
D + ++ G SG + C +RFA
Sbjct: 424 KDNIDPYIYTPFG-SGPRNCIGMRFA 448
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 74.7 bits (182), Expect = 2e-13
Identities = 58/208 (27%), Positives = 104/208 (50%), Gaps = 19/208 (9%)
Query: 252 FIDSLV-----QGN-LNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEE 305
F+D L+ +GN L+ + I E+ F TA W++ L ++ EVQKK+ E
Sbjct: 299 FLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHE 358
Query: 306 INQVFGNG--PVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETL 363
++ VFG P T E +++LRY + V+ ET+R P+ A+ + ++ + + + T
Sbjct: 359 LDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTE 418
Query: 364 VLYALGVVLQDPNTWPSPHKFDPDRFDDELVM--KTFSSLGFS-GTQECPELRFAYMVTT 420
+ + +DP +P+P +F P+RF E ++ + FS G + C +FA M
Sbjct: 419 AVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEK 478
Query: 421 VLLSVLVKRLHL--------LSVEGQVI 440
+LS +++ + L +EGQ+I
Sbjct: 479 TILSCILRHFWIESNQKREELGLEGQLI 506
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 70.1 bits (170), Expect = 4e-12
Identities = 51/166 (30%), Positives = 87/166 (52%), Gaps = 15/166 (9%)
Query: 261 LNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN-GPVTPEK 319
L+D ++ S+IF A T+ + ++ + L T +VQ+KL +EI+ V N P T +
Sbjct: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349
Query: 320 IEQLRYCQHVLCETVRTAKLTPVSAQLQ-----DIEGKIDRFIIPRETLVLYALGVVLQD 374
+ Q+ Y V+ ET+R L PV+ +L+ D+E I+ IP+ ++V+ + D
Sbjct: 350 VVQMEYLDMVVNETLR---LFPVAIRLERTCKKDVE--INGVFIPKGSMVVIPTYALHHD 404
Query: 375 PNTWPSPHKFDPDRFD---DELVMKTFSSLGFSGTQECPELRFAYM 417
P W P +F P+RF D + ++ G +G + C +RFA M
Sbjct: 405 PKYWTEPEEFRPERFSKKKDSIDPYIYTPFG-TGPRNCIGMRFALM 449
>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
Length = 500
Score = 69.7 bits (169), Expect = 5e-12
Identities = 103/459 (22%), Positives = 195/459 (42%), Gaps = 37/459 (8%)
Query: 12 LLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLP-----DIVNSGSLHEFLVNLHERYG 66
LLA +++ A + IPG G+LP D V L + ++ ++YG
Sbjct: 13 LLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYG 72
Query: 67 PVVSFWFGRRLVVSLGTVDVLKQHINP---NKTSDPFETMLKSLLRYQSGGGSVSENHMR 123
PVV + V + + + +K+ + NK S + + G G VSE +
Sbjct: 73 PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYE 132
Query: 124 KKLYENGVTDSL--KSNFALLLKLSEELLDKWLSYPETQ---HVPLS-QHMLGFAMKSV- 176
+ + V D +S+ L++ E ++ + E + P+S Q ML + +
Sbjct: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192
Query: 177 --------TQMVMGSTFEDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNMTRKKQYEDAL 228
T M++G+ Q V + + + K FL G + ++ +++
Sbjct: 193 AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAK-FLPGK----RKQLREVRESI 247
Query: 229 MQLESVLRNIIKERK-GRNFSQHIFIDSLVQ------GNLNDQQILEDSMIFSLASCIIT 281
L V R+ ++ R+ + + D L Q G +D+ +L++ + F +A +
Sbjct: 248 RFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETS 307
Query: 282 AKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTP-EKIEQLRYCQHVLCETVRTAKLT 340
A + + L+ E+ +L E+++V G+ E + +L+Y VL E++R
Sbjct: 308 ANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPA 367
Query: 341 PVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSS 400
+ +L + E ID +P T +L++ V+ + + P F+PDRF F+
Sbjct: 368 WGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTY 427
Query: 401 LGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQ 438
FS G + C +FA M V+++ L++RL V GQ
Sbjct: 428 FPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQ 466
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 69.3 bits (168), Expect = 7e-12
Identities = 55/176 (31%), Positives = 92/176 (52%), Gaps = 18/176 (10%)
Query: 261 LNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN-GPVTPEK 319
L+D +++ S+I A+ T+ + + L T +VQ+KL EEI+ V N PVT +
Sbjct: 290 LSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDA 349
Query: 320 IEQLRYCQHVLCETVRTAKLTPVSAQL-----QDIEGKIDRFIIPRETLVLYALGVVLQD 374
+ Q+ Y V+ ET+R L PV +++ +DIE I+ IP+ V+ + + D
Sbjct: 350 LVQMEYLDMVVNETLR---LFPVVSRVTRVCKKDIE--INGVFIPKGLAVMVPIYALHHD 404
Query: 375 PNTWPSPHKFDPDRFD----DELVMKTFSSLGFSGTQECPELRFAYMVTTVLLSVL 426
P W P KF P+RF D + + + G +G + C +RFA +T + L+V+
Sbjct: 405 PKYWTEPEKFCPERFSKKNKDSIDLYRYIPFG-AGPRNCIGMRFA--LTNIKLAVI 457
>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
precursor [Homo sapiens]
Length = 531
Score = 67.8 bits (164), Expect = 2e-11
Identities = 47/182 (25%), Positives = 86/182 (47%), Gaps = 8/182 (4%)
Query: 256 LVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPV 315
L G L+ ++ + +A T+ TWA+ L+ E+Q+ L+EE+ V G V
Sbjct: 315 LASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQV 374
Query: 316 TPEK-IEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQD 374
K + + VL ET+R + P ++++ + E ++D F+ P+ T ++ VV +D
Sbjct: 375 PQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRD 434
Query: 375 PNTWPSPHKFDPDRF------DDELVMKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLV 427
P + P F P R+ + F S+ F G + C R A + +LL+ L+
Sbjct: 435 PTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLI 494
Query: 428 KR 429
++
Sbjct: 495 QK 496
>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
Length = 508
Score = 65.1 bits (157), Expect = 1e-10
Identities = 96/443 (21%), Positives = 179/443 (40%), Gaps = 68/443 (15%)
Query: 43 GNLPDIVNSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFET 102
G+LP + G +H L ++YGP+ S G + V +G + K+ +
Sbjct: 38 GSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRP 97
Query: 103 MLKSLLRYQSGGGSVSENHMRKKLYENGVTDSLKSNFAL----LLKLSEELLDK------ 152
+ +L S N ++G L A+ L K ++ L+K
Sbjct: 98 QMATL-------DIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEI 150
Query: 153 -----WLSYPETQHVPLSQHMLGFAMKSVTQMVMGSTFED-DQEVIRFQKNHGTVWSEIG 206
L+ Q + +S + ++ + +++++ D E+ Q + + +
Sbjct: 151 STLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLS 210
Query: 207 KG-----------FLDGSLDKNMTRKKQYEDALMQLESVLRNIIKERKGRNFSQHIFIDS 255
K F + +L+K + K D L +L N + K R+ S +D+
Sbjct: 211 KDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLL---NKILENY--KEKFRSDSITNMLDT 265
Query: 256 LVQGNLN----------DQQILEDSMIFSLASCII------TAKLCTWAICFLTTSEEVQ 299
L+Q +N D ++L D+ I + I T + W + FL + +V+
Sbjct: 266 LMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVK 325
Query: 300 KKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVR-TAKLTPVSAQL----QDIEGKID 354
KKLYEEI+Q G TP ++ R +L T+R +L PV+ L +++ I
Sbjct: 326 KKLYEEIDQNVGFSR-TPTISDRNRLL--LLEATIREVLRLRPVAPMLIPHKANVDSSIG 382
Query: 355 RFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF----DDELVMKTFSSLGF-SGTQEC 409
F + + T V+ L + + W P +F P+RF +L+ + S L F +G + C
Sbjct: 383 EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSC 442
Query: 410 PELRFAYMVTTVLLSVLVKRLHL 432
A ++++ L++R L
Sbjct: 443 IGEILARQELFLIMAWLLQRFDL 465
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 64.7 bits (156), Expect = 2e-10
Identities = 55/177 (31%), Positives = 92/177 (51%), Gaps = 19/177 (10%)
Query: 261 LNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN-GPVTPEK 319
L+D +++ S+I A+ T+ + + L T +VQ+KL EEI+ V N PVT +
Sbjct: 290 LSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDA 349
Query: 320 IEQLRYCQHVLCETVRTAKLTPVSAQL-----QDIEGKIDRFIIPRETLVLYALGVVLQD 374
+ Q+ Y V+ ET+R L PV +++ +DIE I+ IP+ V+ + + D
Sbjct: 350 LVQMEYLDMVVNETLR---LFPVVSRVTRVCKKDIE--INGVFIPKGLAVMVPIYALHHD 404
Query: 375 PNTWPSPHKFDPD-RFD----DELVMKTFSSLGFSGTQECPELRFAYMVTTVLLSVL 426
P W P KF P+ RF D + + + G +G + C +RFA +T + L+V+
Sbjct: 405 PKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFG-AGPRNCIGMRFA--LTNIKLAVI 458
>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
[Homo sapiens]
Length = 490
Score = 64.7 bits (156), Expect = 2e-10
Identities = 102/423 (24%), Positives = 171/423 (40%), Gaps = 60/423 (14%)
Query: 58 LVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSV 117
L+ L ERYGPV + GR+ V L + +K+ + + Q GGG
Sbjct: 56 LMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIF 115
Query: 118 SENHMR---------KKLYENGV-TDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQH 167
+ R + L+ GV + + LK LD + P PL+
Sbjct: 116 FSSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRP----FPLA-- 169
Query: 168 MLGFAMKSVT-QMVMGSTFEDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNMTRKKQYED 226
+LG+A ++T ++ G F+ V F G + + L GS + +
Sbjct: 170 LLGWAPSNITFALLFGRRFDYRDPV--FVSLLGLIDEVM---VLLGSPGLQLFNVYPWLG 224
Query: 227 ALMQLE-----------SVLRNIIKERKGRNFSQHI--------FIDSLVQGNLNDQ--- 264
AL+QL ++LR +++ R+ H+ ++D+L+Q D
Sbjct: 225 ALLQLHRPVLRKIEEVRAILRTLLEARR-----PHVCPGDPVCSYVDALIQQGQGDDPEG 279
Query: 265 -----QILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEK 319
+ ++ +A T+ WA + +VQ ++ EE+++V G G TP
Sbjct: 280 LFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGR-TPRL 338
Query: 320 IEQ--LRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNT 377
+Q L Y VL E R L P + + ++ F++P+ T V+ L VL D
Sbjct: 339 EDQQALPYTSAVLHEVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQ 398
Query: 378 WPSPHKFDPDRFDDE--LVMKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLS 434
W +P +F+P F D +K + L FS G + C R A +L + L++R LL
Sbjct: 399 WQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLP 458
Query: 435 VEG 437
G
Sbjct: 459 PPG 461
>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
[Homo sapiens]
Length = 519
Score = 63.2 bits (152), Expect = 5e-10
Identities = 54/215 (25%), Positives = 98/215 (45%), Gaps = 5/215 (2%)
Query: 223 QYEDALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGN-LNDQQILEDSMIFSLASCIIT 281
Q A +Q E L I K ++ +F + + + G+ L+D+ + + F T
Sbjct: 268 QLRKAQLQKEGELEKI-KRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTT 326
Query: 282 AKLCTWAICFLTTSEEVQKKLYEEINQVFGNGP-VTPEKIEQLRYCQHVLCETVRTAKLT 340
A +W + L T + Q++ EEI+ + G+G +T ++Q+ Y + E +R
Sbjct: 327 ASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPV 386
Query: 341 P-VSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFS 399
P + +L D +P+ +VL ++ + +P WP+P FDP RF + +
Sbjct: 387 PGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHA 446
Query: 400 SLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLL 433
L FS G++ C +FA V ++ + R LL
Sbjct: 447 FLPFSGGSRNCIGKQFAMNELKVATALTLLRFELL 481
>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
[Homo sapiens]
Length = 501
Score = 62.0 bits (149), Expect = 1e-09
Identities = 57/221 (25%), Positives = 101/221 (45%), Gaps = 11/221 (4%)
Query: 252 FIDSLVQG-NLNDQQILEDSMIFSLASCII-----TAKLCTWAICFLTTSEEVQKKLYEE 305
++D + QG N ++++IFS+ II T + WAI F+ +Q ++ +E
Sbjct: 280 YLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKE 339
Query: 306 INQVFG-NGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDR-FIIPRETL 363
I+ + G NG + + ++ Y + VL E +R + P+ E + R + IP+ T
Sbjct: 340 IDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTT 399
Query: 364 VLYALGVVLQDPNTWPSPHKFDPDRFDDE--LVMKTFSSLGFS-GTQECPELRFAYMVTT 420
V+ L V D W P F P+RF D K + + FS G + C A M
Sbjct: 400 VITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMF 459
Query: 421 VLLSVLVKRLHLLSVEGQVIETKYELVTSSREEAWITVSKR 461
+ + L++R HL V + K L + + + ++ ++R
Sbjct: 460 LFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAER 500
>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 3 [Homo sapiens]
Length = 420
Score = 60.8 bits (146), Expect = 2e-09
Identities = 44/134 (32%), Positives = 71/134 (52%), Gaps = 11/134 (8%)
Query: 261 LNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGN-GPVTPEK 319
L+D +++ S+I A+ T+ + + L T +VQ+KL EEI+ V N PVT +
Sbjct: 290 LSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDA 349
Query: 320 IEQLRYCQHVLCETVRTAKLTPVSAQL-----QDIEGKIDRFIIPRETLVLYALGVVLQD 374
+ Q+ Y V+ ET+R L PV +++ +DIE I+ IP+ V+ + + D
Sbjct: 350 LVQMEYLDMVVNETLR---LFPVVSRVTRVCKKDIE--INGVFIPKGLAVMVPIYALHHD 404
Query: 375 PNTWPSPHKFDPDR 388
P W P KF P+R
Sbjct: 405 PKYWTEPEKFCPER 418
>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 514
Score = 60.1 bits (144), Expect = 4e-09
Identities = 89/450 (19%), Positives = 179/450 (39%), Gaps = 41/450 (9%)
Query: 26 SRQAAGIPGITPTEEKDGNLPDIVNSGSL---HEFLVNLHERYGPVVSFWFGRRLVVSLG 82
++ AA +PG T G+L I+ G L H+ LV H++YG + G V LG
Sbjct: 52 TQNAAALPGPTSWPLL-GSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLG 110
Query: 83 TVDVLKQ------------HINPNKTSDPFETMLKSLLRYQSGGGSVSENHMRKKLYENG 130
+ +L+ I P K + LL + + +KKL + G
Sbjct: 111 SPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPG 170
Query: 131 ----VTDSLKSNFALLLKLSEELLDKWLSYPETQHVP-LSQHMLGFAMKSVTQMVMGSTF 185
+ + + A + +EL D E HV L + ++ +S+ ++ F
Sbjct: 171 EVMKLDNKINEVLADFMGRIDELCD------ERGHVEDLYSELNKWSFESICLVLYEKRF 224
Query: 186 -----EDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNMTRKKQYEDALMQLESVLRNIIK 240
E + F T+ S G+ + K ++D + +++ +++
Sbjct: 225 GLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKA 284
Query: 241 ------ERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTT 294
E+ + S D Q L+ +++ LA+ TA W + L+
Sbjct: 285 CIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSR 344
Query: 295 SEEVQKKLYEEINQVFGNGPV-TPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKI 353
+ +VQ+KL +EI V V E + + Y + L E++R P + + D +
Sbjct: 345 NPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVL 404
Query: 354 DRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF-DDELVMKTFSSLGFS-GTQECPE 411
+ +P+ T+++ V+ + + +F P+R+ ++ + F+ L F G + C
Sbjct: 405 GEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIG 464
Query: 412 LRFAYMVTTVLLSVLVKRLHLLSVEGQVIE 441
R A + + L +V++ + + + + +E
Sbjct: 465 RRLAELQLHLALCWIVRKYDIQATDNEPVE 494
>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 60.1 bits (144), Expect = 4e-09
Identities = 55/179 (30%), Positives = 86/179 (48%), Gaps = 16/179 (8%)
Query: 261 LNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKI 320
L +I+ + IF +A I ++A L T+ + Q+KL E++ VF + PE
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFC 385
Query: 321 ---EQLRYCQHVLCETVR----TAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQ 373
E L Y V+ ET+R + T +AQ ++ G+ IP ++ A+G +
Sbjct: 386 SLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR----IPAGAVLEMAVGALHH 441
Query: 374 DPNTWPSPHKFDPDRFDDELVM--KTFSSLGF-SGTQECPELRFAYM-VTTVLLSVLVK 428
DP WPSP F+P+RF E + F+ L F +G + C +R + V LL VL K
Sbjct: 442 DPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHK 500
Score = 34.3 bits (77), Expect = 0.24
Identities = 25/85 (29%), Positives = 45/85 (52%), Gaps = 5/85 (5%)
Query: 56 EFLVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGG 115
E + L + YGP+ ++ GRR+ + + D++KQ + N ++ F + S L ++S
Sbjct: 66 ESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSN--FTNRMASGLEFKSVAD 123
Query: 116 SVSENHMRKKLYENGVTDSLKSNFA 140
SV +R K +E V +L S F+
Sbjct: 124 SVL--FLRDKRWEE-VRGALMSAFS 145
>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 60.1 bits (144), Expect = 4e-09
Identities = 55/179 (30%), Positives = 86/179 (48%), Gaps = 16/179 (8%)
Query: 261 LNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKI 320
L +I+ + IF +A I ++A L T+ + Q+KL E++ VF + PE
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFC 385
Query: 321 ---EQLRYCQHVLCETVR----TAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQ 373
E L Y V+ ET+R + T +AQ ++ G+ IP ++ A+G +
Sbjct: 386 SLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR----IPAGAVLEMAVGALHH 441
Query: 374 DPNTWPSPHKFDPDRFDDELVM--KTFSSLGF-SGTQECPELRFAYM-VTTVLLSVLVK 428
DP WPSP F+P+RF E + F+ L F +G + C +R + V LL VL K
Sbjct: 442 DPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHK 500
Score = 34.3 bits (77), Expect = 0.24
Identities = 25/85 (29%), Positives = 45/85 (52%), Gaps = 5/85 (5%)
Query: 56 EFLVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGG 115
E + L + YGP+ ++ GRR+ + + D++KQ + N ++ F + S L ++S
Sbjct: 66 ESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSN--FTNRMASGLEFKSVAD 123
Query: 116 SVSENHMRKKLYENGVTDSLKSNFA 140
SV +R K +E V +L S F+
Sbjct: 124 SVL--FLRDKRWEE-VRGALMSAFS 145
>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
[Homo sapiens]
Length = 519
Score = 59.3 bits (142), Expect = 7e-09
Identities = 53/215 (24%), Positives = 97/215 (45%), Gaps = 5/215 (2%)
Query: 223 QYEDALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGN-LNDQQILEDSMIFSLASCIIT 281
Q A +Q E L I K ++ +F + + + G+ L+D+ + + F T
Sbjct: 268 QLRKAQLQKEGELEKI-KRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTT 326
Query: 282 AKLCTWAICFLTTSEEVQKKLYEEINQVFGNGP-VTPEKIEQLRYCQHVLCETVRTAKLT 340
A +W + L T + Q++ EEI+ + G+G +T ++Q+ Y + E +R
Sbjct: 327 ASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPV 386
Query: 341 P-VSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFS 399
P + +L D +P+ +VL ++ + +P WP+ FDP RF + +
Sbjct: 387 PGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSHA 446
Query: 400 SLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLL 433
L FS G++ C +FA V ++ + R LL
Sbjct: 447 FLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELL 481
>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
[Homo sapiens]
Length = 502
Score = 58.9 bits (141), Expect = 9e-09
Identities = 32/133 (24%), Positives = 68/133 (51%), Gaps = 4/133 (3%)
Query: 260 NLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNG--PVTP 317
+ +++ ++ ++ A T+ WA+ ++ E+Q+K+ EI++V G G P T
Sbjct: 295 SFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTA 354
Query: 318 EKIEQLRYCQHVLCETVRTAKLTPVSAQLQ-DIEGKIDRFIIPRETLVLYALGVVLQDPN 376
+ E + Y V+ E R + P++ + ++ + + +P+ T++L L + +DP
Sbjct: 355 AR-ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPT 413
Query: 377 TWPSPHKFDPDRF 389
W +P F+PD F
Sbjct: 414 EWATPDTFNPDHF 426
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 58.2 bits (139), Expect = 2e-08
Identities = 42/150 (28%), Positives = 71/150 (47%), Gaps = 9/150 (6%)
Query: 275 LASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFG--NGPVTPEKIEQLRYCQHVLCE 332
+A T W + +++ + +VQ+K++EEI +V G P +K Q+ Y + + E
Sbjct: 351 IAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKA-QMPYTEATIME 409
Query: 333 TVRTAKLTPVSAQLQDIEGKI-DRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDD 391
R + P++ E + + IP+ TL+L L V +DP W P F P+RF D
Sbjct: 410 VQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLD 469
Query: 392 E----LVMKTFSSLGFSGTQECPELRFAYM 417
+ + +TF G G + C + A M
Sbjct: 470 DQGQLIKKETFIPFGI-GKRVCMGEQLAKM 498
>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 1 [Homo sapiens]
Length = 509
Score = 57.0 bits (136), Expect = 4e-08
Identities = 88/432 (20%), Positives = 175/432 (40%), Gaps = 39/432 (9%)
Query: 56 EFLVNLHERYGPVVSF-WFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGG 114
EFL N +E+YGPV SF G+ LG+ D N E + L G
Sbjct: 89 EFLENAYEKYGPVFSFTMVGKTFTYLLGS-DAAALLFNSKNEDLNAEDVYSRLTTPVFGK 147
Query: 115 GSVSE--NHM---RKKLYENGVTDS-LKSNFALLLKLSEELLDKWLSYPETQHVPLSQHM 168
G + N + +KK+ ++G+ + K + +++ K ++E + W E+ + + +
Sbjct: 148 GVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESW---GESGEKNVFEAL 204
Query: 169 LGFAMKSVTQMVMGSTFEDDQEVIRFQKNH--GTVWSEIGKGF------LDGSLDKNMTR 220
+ + + + G + IR Q N +++++ GF L G L R
Sbjct: 205 SELIILTASHCLHG-------KEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFR 257
Query: 221 KKQYEDALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCII 280
++ + A +++ + I++R+ + +L+ D + L D + + ++
Sbjct: 258 RR--DRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLL 315
Query: 281 TAKLCT------WAICFLTTSEEVQKKLYEEINQVFGNG--PVTPEKIEQLRYCQHVLCE 332
A T W FL + +QKK Y E V G P+T ++++ L + E
Sbjct: 316 LAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKE 375
Query: 333 TVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF--D 390
T+R + ++ + + IP V + V + ++W F+PDR+ D
Sbjct: 376 TLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQD 435
Query: 391 DELVMKTFSSLGF-SGTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVIETKYELVTS 449
+ + F+ + F +G C FAY+ + S +++ ++G Y +
Sbjct: 436 NPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIH 495
Query: 450 SREEAWITVSKR 461
+ E I +R
Sbjct: 496 TPENPVIRYKRR 507
>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
[Homo sapiens]
Length = 494
Score = 57.0 bits (136), Expect = 4e-08
Identities = 93/434 (21%), Positives = 172/434 (39%), Gaps = 57/434 (13%)
Query: 1 MLDFAIFAVTFLLALVGAVLYLYPASRQAAGI--PGITPTEEKDGNLPDIVNSGSLHEFL 58
ML + VT L L VL R++ G PG TP L +N+ ++ L
Sbjct: 1 MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQ--LNTEQMYNSL 58
Query: 59 VNLHERYGPVVSFWFGRRLVVSLGTVDVLK-------QHINPNKTSDPFETMLKSL-LRY 110
+ + ERYGPV + G R VV L D +K + + F+ + K + +
Sbjct: 59 MKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAF 118
Query: 111 QSG---------------GGSVSENHMRKKLYENG--VTDSLKSNFALLLK--------- 144
+G G V + + +++ E + D+L+ +
Sbjct: 119 SNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTV 178
Query: 145 ---LSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMVMGSTFEDDQEVIRFQKNHGTV 201
+S + Y + + + L + MLG + T G +E V++
Sbjct: 179 SNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATST--GQLYEMFSSVMKHLPGPQQQ 236
Query: 202 WSEIGKGFLDGSLDKNMTRKKQYEDALMQLESVLRNIIK-ERKGRNFSQHIFIDSLVQGN 260
+ +G L+ + K + ++ D + + +I+ + + +N + ++ +LV
Sbjct: 237 AFKELQG-LEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTT 295
Query: 261 LNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFG-NGPVTPEK 319
LN + F+ + T + L EV+ K++EEI++V G N E
Sbjct: 296 LN--------LFFAGTETVSTT--LRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFED 345
Query: 320 IEQLRYCQHVLCETVRTAKLTPVS-AQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTW 378
++ Y + V+ E R + P+ A + + K F +P+ T V LG VL+DP +
Sbjct: 346 RAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFF 405
Query: 379 PSPHKFDPDRFDDE 392
+P F+P F D+
Sbjct: 406 SNPRDFNPQHFLDK 419
>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
[Homo sapiens]
Length = 520
Score = 57.0 bits (136), Expect = 4e-08
Identities = 52/209 (24%), Positives = 94/209 (44%), Gaps = 16/209 (7%)
Query: 261 LNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKI 320
L+D+ I ++ F TA +W + L E Q++ +E+ ++ + P++I
Sbjct: 313 LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRE--PKEI 370
Query: 321 E-----QLRYCQHVLCETVRTAKLTPVSAQ--LQDIEGKIDRFIIPRETLVLYALGVVLQ 373
E QL + L E++R P A+ QD+ R +IP+ + + +
Sbjct: 371 EWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSR-VIPKGNVCNINIFAIHH 429
Query: 374 DPNTWPSPHKFDPDRFDDELVMKTFSSLGF----SGTQECPELRFAYMVTTVLLSVLVKR 429
+P+ WP P +DP RFD E K S + F +G + C +FA V+L++ + R
Sbjct: 430 NPSVWPDPEVYDPFRFDPENAQKR-SPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLR 488
Query: 430 LHLLSVEGQVIETKYELVTSSREEAWITV 458
+L + T E+V + + W+ V
Sbjct: 489 FRILPDHREPRRTP-EIVLRAEDGLWLRV 516
>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
[Homo sapiens]
Length = 508
Score = 56.2 bits (134), Expect = 6e-08
Identities = 52/203 (25%), Positives = 89/203 (43%), Gaps = 6/203 (2%)
Query: 230 QLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAI 289
+ E+ +RN + K H+ L + L Q IL + LA + +WA+
Sbjct: 272 EAEAAMRNGGQPEKDLESGAHL-THFLFREELPAQSILGNVTELLLAGVDTVSNTLSWAL 330
Query: 290 CFLTTSEEVQKKLYEEINQVFGNGPV---TPEKIEQLRYCQHVLCETVRTAKLTPVSAQL 346
L+ EVQ L+ EI G + + QL + V+ E +R + P ++++
Sbjct: 331 YELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRV 390
Query: 347 QDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE-LVMKTFSSLGFS- 404
D + + +IIP+ TLV +DP +P P+ F P R+ E F+SL F
Sbjct: 391 PDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGF 450
Query: 405 GTQECPELRFAYMVTTVLLSVLV 427
G + C R A + + L+ ++
Sbjct: 451 GKRSCMGRRLAELELQMALAQIL 473
>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
[Homo sapiens]
Length = 490
Score = 54.7 bits (130), Expect = 2e-07
Identities = 104/459 (22%), Positives = 182/459 (39%), Gaps = 38/459 (8%)
Query: 12 LLALVGAVLYLYPASRQAAGI----PGITPTEEKDGNLPDIVNSGSLHEFLVNLHERYGP 67
+L L + L L RQ++G PG TP GN+ I + + + L NL + YGP
Sbjct: 6 VLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVI-GNILQI-DIKDVSKSLTNLSKIYGP 63
Query: 68 VVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSENHMRKKLY 127
V + +FG +V L +V+K+ + R G G V N R K
Sbjct: 64 VFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEI 123
Query: 128 ENGVTDSLKSNFALLLKLSEELLDKWL-----SYPETQHVPLSQ-HMLGFAMKSVTQMVM 181
+L+ NF + + E+ + + +T+ P +LG A +V ++
Sbjct: 124 RRFSLMTLR-NFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182
Query: 182 GST---FEDDQEVIRFQKNH------GTVWSEIGKGF------LDGSLDKNMTRKKQYED 226
++D Q + +K + T W +I F G+ +K + E
Sbjct: 183 FQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMES 242
Query: 227 ALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCI-----IT 281
+++ + + R+F I + + ++++ + A + T
Sbjct: 243 DILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETT 302
Query: 282 AKLCTWAICFLTTSEEVQKKLYEEINQVFG-NGPVTPEKIEQLRYCQHVLCETVRTAKLT 340
+ +A+ L EV K+ EEI +V G N + + Y V+ E R L
Sbjct: 303 STTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLI 362
Query: 341 PVSA-QLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE--LVMKT 397
P S + K ++IP+ T +L +L VL D +P+P FDP F DE K+
Sbjct: 363 PTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKS 422
Query: 398 FSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSV 435
+ FS G + C A M + L+ +++ +L S+
Sbjct: 423 NYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSL 461
>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
[Homo sapiens]
Length = 494
Score = 54.7 bits (130), Expect = 2e-07
Identities = 104/507 (20%), Positives = 199/507 (39%), Gaps = 65/507 (12%)
Query: 1 MLDFAIFAVTFLLALVGAVLYLYPASRQAAGI--PGITPTEEKDGNLPDIVNSGSLHEFL 58
ML + V L+ L VL R++ G PG TP L +N+ ++ L
Sbjct: 1 MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQ--LNTEQMYNSL 58
Query: 59 VNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVS 118
+ + ERYGPV + G R VV L D +++ + + G G V
Sbjct: 59 MKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVF 118
Query: 119 ENHMRKK--------------LYENGVTDSLKSNFALLLK-------------------- 144
N R K + + G+ + ++ L+
Sbjct: 119 SNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTV 178
Query: 145 ---LSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMVMGSTFEDDQEVIRFQKNHGTV 201
+S + Y + + + L + MLG + T G +E V++
Sbjct: 179 SNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTST--GQLYEMFSSVMKHLPGPQQQ 236
Query: 202 WSEIGKGFLDGSLDKNMTRKKQYEDALMQLESVLRNIIK-ERKGRNFSQHIFIDSLVQGN 260
++ +G L+ + K + ++ D + + +I+ + + +N + ++ +LV
Sbjct: 237 AFQLLQG-LEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTT 295
Query: 261 LNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFG-NGPVTPEK 319
LN +F + ++ L + L EV+ K++EEI++V G N E
Sbjct: 296 LN---------LFIGGTETVSTTL-RYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFED 345
Query: 320 IEQLRYCQHVLCETVRTAKLTPVS-AQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTW 378
++ Y + V+ E R + P+S A+ + K F +P+ T V LG VL+DP+ +
Sbjct: 346 RAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFF 405
Query: 379 PSPHKFDPDRFDDE--LVMKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSV 435
+P F+P F +E K+ + + FS G + C A M + + +++ L S
Sbjct: 406 SNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKS- 464
Query: 436 EGQVIETKYELVTSSREEAWITVSKRY 462
++ ++ S + + T+ + Y
Sbjct: 465 ----SQSPKDIDVSPKHVGFATIPRNY 487
>gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II
[Homo sapiens]
Length = 460
Score = 54.3 bits (129), Expect = 2e-07
Identities = 41/136 (30%), Positives = 67/136 (49%), Gaps = 12/136 (8%)
Query: 261 LNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKI 320
L +I+ + IF +A I ++A L T+ + Q+KL E++ VF + PE
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFC 385
Query: 321 ---EQLRYCQHVLCETVR----TAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQ 373
E L Y V+ ET+R + T +AQ ++ G+ IP ++ A+G +
Sbjct: 386 SLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR----IPAGAVLEMAVGALHH 441
Query: 374 DPNTWPSPHKFDPDRF 389
DP WPSP F+P+R+
Sbjct: 442 DPEHWPSPETFNPERY 457
Score = 34.3 bits (77), Expect = 0.24
Identities = 25/85 (29%), Positives = 45/85 (52%), Gaps = 5/85 (5%)
Query: 56 EFLVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGG 115
E + L + YGP+ ++ GRR+ + + D++KQ + N ++ F + S L ++S
Sbjct: 66 ESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSN--FTNRMASGLEFKSVAD 123
Query: 116 SVSENHMRKKLYENGVTDSLKSNFA 140
SV +R K +E V +L S F+
Sbjct: 124 SVL--FLRDKRWEE-VRGALMSAFS 145
>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
[Homo sapiens]
Length = 520
Score = 53.9 bits (128), Expect = 3e-07
Identities = 54/209 (25%), Positives = 93/209 (44%), Gaps = 16/209 (7%)
Query: 261 LNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKI 320
L+D+ I ++ F TA +W + L E Q++ +E+ ++ + P++I
Sbjct: 313 LSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDRE--PKEI 370
Query: 321 E-----QLRYCQHVLCETVRTAKLTPVSAQ--LQDIEGKIDRFIIPRETLVLYALGVVLQ 373
E L + + E++R PV ++ QDI R +IP+ + L ++
Sbjct: 371 EWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGR-VIPKGIICLISVFGTHH 429
Query: 374 DPNTWPSPHKFDPDRFDDELVMKTFSSLGF----SGTQECPELRFAYMVTTVLLSVLVKR 429
+P WP P +DP RFD E + K S L F +G + C FA V+L++ + R
Sbjct: 430 NPAVWPDPEVYDPFRFDPENI-KERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLR 488
Query: 430 LHLLSVEGQVIETKYELVTSSREEAWITV 458
+L + K ELV + W+ V
Sbjct: 489 FRVLPDHTEP-RRKPELVLRAEGGLWLRV 516
>gi|13904858 cytochrome P450, family 19 [Homo sapiens]
Length = 503
Score = 53.5 bits (127), Expect = 4e-07
Identities = 42/231 (18%), Positives = 108/231 (46%), Gaps = 12/231 (5%)
Query: 222 KQYEDALMQLESVLRNIIKERKGRNFSQHI------FIDSLV----QGNLNDQQILEDSM 271
K+YE ++ L+ + +I E++ R ++ F L+ +G+L + + + +
Sbjct: 242 KKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCIL 301
Query: 272 IFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLC 331
+A+ + + + + V++ + +EI V G + + I++L+ ++ +
Sbjct: 302 EMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIY 361
Query: 332 ETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDD 391
E++R + + + + ID + + + T ++ +G + +P P++F + F
Sbjct: 362 ESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGR-MHRLEFFPKPNEFTLENFAK 420
Query: 392 ELVMKTFSSLGFSGTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVIET 442
+ + F GF G + C A ++ +L L++R H+ +++GQ +E+
Sbjct: 421 NVPYRYFQPFGF-GPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVES 470
>gi|13904860 cytochrome P450, family 19 [Homo sapiens]
Length = 503
Score = 53.5 bits (127), Expect = 4e-07
Identities = 42/231 (18%), Positives = 108/231 (46%), Gaps = 12/231 (5%)
Query: 222 KQYEDALMQLESVLRNIIKERKGRNFSQHI------FIDSLV----QGNLNDQQILEDSM 271
K+YE ++ L+ + +I E++ R ++ F L+ +G+L + + + +
Sbjct: 242 KKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCIL 301
Query: 272 IFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLC 331
+A+ + + + + V++ + +EI V G + + I++L+ ++ +
Sbjct: 302 EMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIY 361
Query: 332 ETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDD 391
E++R + + + + ID + + + T ++ +G + +P P++F + F
Sbjct: 362 ESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGR-MHRLEFFPKPNEFTLENFAK 420
Query: 392 ELVMKTFSSLGFSGTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVIET 442
+ + F GF G + C A ++ +L L++R H+ +++GQ +E+
Sbjct: 421 NVPYRYFQPFGF-GPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVES 470
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,537,780
Number of Sequences: 37866
Number of extensions: 712356
Number of successful extensions: 1885
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 1771
Number of HSP's gapped (non-prelim): 104
length of query: 462
length of database: 18,247,518
effective HSP length: 106
effective length of query: 356
effective length of database: 14,233,722
effective search space: 5067205032
effective search space used: 5067205032
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.