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Search of human proteins with 29029632
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
(1620 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 3343 0.0
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 910 0.0
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 783 0.0
gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precur... 444 e-124
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 301 3e-81
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 279 1e-74
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 263 1e-69
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 259 2e-68
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 259 2e-68
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 231 4e-60
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 231 4e-60
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 230 7e-60
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 230 7e-60
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 230 7e-60
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 227 8e-59
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 223 1e-57
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 220 8e-57
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 220 8e-57
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 220 8e-57
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 220 8e-57
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens] 218 4e-56
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens] 218 4e-56
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 213 9e-55
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 211 4e-54
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 211 4e-54
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 211 4e-54
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 211 4e-54
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso... 210 8e-54
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 210 8e-54
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [... 210 8e-54
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 3343 bits (8669), Expect = 0.0
Identities = 1620/1620 (100%), Positives = 1620/1620 (100%)
Query: 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVV 60
MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVV
Sbjct: 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVV 60
Query: 61 PSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEA 120
PSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEA
Sbjct: 61 PSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEA 120
Query: 121 RTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQ 180
RTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQ
Sbjct: 121 RTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQ 180
Query: 181 GEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDY 240
GEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDY
Sbjct: 181 GEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDY 240
Query: 241 FTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQ 300
FTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQ
Sbjct: 241 FTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQ 300
Query: 301 MDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGR 360
MDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGR
Sbjct: 301 MDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGR 360
Query: 361 YIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFF 420
YIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFF
Sbjct: 361 YIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFF 420
Query: 421 ALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYC 480
ALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYC
Sbjct: 421 ALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYC 480
Query: 481 NFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFP 540
NFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFP
Sbjct: 481 NFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFP 540
Query: 541 APIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPL 600
APIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPL
Sbjct: 541 APIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPL 600
Query: 601 LDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNP 660
LDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNP
Sbjct: 601 LDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNP 660
Query: 661 NKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPL 720
NKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPL
Sbjct: 661 NKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPL 720
Query: 721 KGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGE 780
KGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGE
Sbjct: 721 KGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGE 780
Query: 781 DACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLII 840
DACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLII
Sbjct: 781 DACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLII 840
Query: 841 AAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGA 900
AAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGA
Sbjct: 841 AAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGA 900
Query: 901 TGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFIS 960
TGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFIS
Sbjct: 901 TGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFIS 960
Query: 961 PLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVS 1020
PLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVS
Sbjct: 961 PLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVS 1020
Query: 1021 CIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKL 1080
CIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKL
Sbjct: 1021 CIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKL 1080
Query: 1081 SKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPN 1140
SKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPN
Sbjct: 1081 SKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPN 1140
Query: 1141 DPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMA 1200
DPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMA
Sbjct: 1141 DPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMA 1200
Query: 1201 GGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCP 1260
GGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCP
Sbjct: 1201 GGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCP 1260
Query: 1261 GPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLW 1320
GPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLW
Sbjct: 1261 GPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLW 1320
Query: 1321 EIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIIL 1380
EIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIIL
Sbjct: 1321 EIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIIL 1380
Query: 1381 ERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAA 1440
ERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAA
Sbjct: 1381 ERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAA 1440
Query: 1441 PPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPT 1500
PPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPT
Sbjct: 1441 PPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPT 1500
Query: 1501 SLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPS 1560
SLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPS
Sbjct: 1501 SLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPS 1560
Query: 1561 SLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 1620
SLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP
Sbjct: 1561 SLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 1620
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 910 bits (2352), Expect = 0.0
Identities = 477/858 (55%), Positives = 585/858 (68%), Gaps = 33/858 (3%)
Query: 608 WLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPG 667
W Q++ W+G + + S + +L S L +P R+ P L+P
Sbjct: 4 WGQLLVWFGAAGAILCSSPG---SQETFLRSSP----LPLASPSPRDPKVSAPPSILEPA 56
Query: 668 ENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWK 727
SP +P + + WLF+TCGASG HGPTQ QC+ AY +++ V VG+ G L+G+Q+W+
Sbjct: 57 --SPLNSPGTEGS--WLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWR 112
Query: 728 VPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTN 787
VP Y IS YGAAGGKG KN + R+HGV V IF+L + LYILVGQQGEDACP +
Sbjct: 113 VPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGS 172
Query: 788 QLIQKVCIGENNVIEEEIRVNRSV-----HEWAGGGGGGGGATYVFKMKDGVPVPLIIAA 842
Q VC+GE+ +EE ++ S WAGGGGGGGGATYVF+++ G PL++AA
Sbjct: 173 PESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAA 232
Query: 843 GGGGRAYGAKTDTFH----PERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQE 898
GGGGRAY D PE+LEN S G G GAAGGGGGW AG+SLQE
Sbjct: 233 GGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQE 292
Query: 899 GATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSF 958
GA GG C +A GW GGFGGGGG C++GGGGGGY GG+A+ ++ DGEDGVSF
Sbjct: 293 GAEGGQGCSEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSF 352
Query: 959 ISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDG 1018
I P L+ L V E HGEV I+ +LNCSHC + +C E C C G LA D
Sbjct: 353 IHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDN 412
Query: 1019 VSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMI-VYRRKHQELQAMQMELQSPE 1077
V+C+ +P PL L+++VV ++ ++ L++ G++I V ++K Q LQ +M L SPE
Sbjct: 413 VTCM--DLHKPPGPLVLMVAVVATSTLSLLMVC--GVLILVKQKKWQGLQ--EMRLPSPE 466
Query: 1078 YKLSKLRTSTIMTDYNPNYCFAGKTSSIS-----DLKEVPRKNITLIRGLGHGAFGEVYE 1132
+LSKLRTS I T NP YC G + S + EV N+TL+R LGHGAFGEVYE
Sbjct: 467 LELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYE 526
Query: 1133 GQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPR 1192
G V G+P D SPLQVA+KTLPE+CS QDELDFLMEALIISKF HQNIVRC+G+SL++ PR
Sbjct: 527 GLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPR 586
Query: 1193 FILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAA 1252
ILLELM+GGD+KSFLR +RP QPS L M DLL +A+DIA GC YLEENHFIHRDIAA
Sbjct: 587 LILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAA 646
Query: 1253 RNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDT 1312
RNCLL+C GP RVAKIGDFGMARDIYRASYYR+G A+LPVKWMPPEAF+EGIFTSKTD+
Sbjct: 647 RNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDS 706
Query: 1313 WSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPED 1372
WSFGVLLWEIFSLGYMPYP ++NQEVL+FV GGRMDPP+ CPGPVYRIMTQCWQH+PE
Sbjct: 707 WSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPEL 766
Query: 1373 RPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKR 1432
RP+FA ILER++YCTQDPDV+N+ LP+E GP EEE + + E + P Q+
Sbjct: 767 RPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRP-PQPQELSP 825
Query: 1433 EEERSPAAPPPLPTTSSG 1450
E+ +S P P SSG
Sbjct: 826 EKLKSWGGSPLGPWLSSG 843
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 783 bits (2023), Expect = 0.0
Identities = 437/854 (51%), Positives = 545/854 (63%), Gaps = 86/854 (10%)
Query: 608 WLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPG 667
W Q++ W+G + + S + +L S L +P R+ P L+P
Sbjct: 4 WGQLLVWFGAAGAILCSSPG---SQETFLRSSP----LPLASPSPRDPKVSAPPSILEPA 56
Query: 668 ENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWK 727
SP +P + + WLF+TCGASG HGPTQ QC+ AY +++ V VG+ G L+G+Q+W+
Sbjct: 57 --SPLNSPGTEGS--WLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWR 112
Query: 728 VPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTN 787
VP Y IS YGAAGGKG KN + R+HGV V IF+L + LYILVGQQGEDACP +
Sbjct: 113 VPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGS 172
Query: 788 QLIQKVCIGENNVIEEEIRVNRSV-----HEWAGGGGGGGGATYVFKMKDGVPVPLIIAA 842
Q VC+GE+ +EE ++ S WAGGGGGGGGATYVF+++ G PL++
Sbjct: 173 PESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLV-- 230
Query: 843 GGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATG 902
AAGGGG + L + G T
Sbjct: 231 ---------------------------------AAGGGG-----RAYL---RPRDRGRT- 248
Query: 903 GHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPL 962
+ P+ + E R G GG GG GG+A+ ++ DGEDGVSFI P
Sbjct: 249 -QASPEKL-----ENRSEAPGSGGR-------GGAAGGDASETDNLWADGEDGVSFIHPS 295
Query: 963 GILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCI 1022
L+ L V E HGEV I+ +LNCSHC + +C E C C G LA D V+C+
Sbjct: 296 SELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCM 355
Query: 1023 VSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMI-VYRRKHQELQAMQMELQSPEYKLS 1081
+P PL L+++VV ++ ++ L++ G++I V ++K Q LQ +M L SPE +LS
Sbjct: 356 --DLHKPPGPLVLMVAVVATSTLSLLMVC--GVLILVKQKKWQGLQ--EMRLPSPELELS 409
Query: 1082 KLRTSTIMTDYNPNYCFAGKTSSIS-----DLKEVPRKNITLIRGLGHGAFGEVYEGQVS 1136
KLRTS I T NP YC G + S + EV N+TL+R LGHGAFGEVYEG V
Sbjct: 410 KLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVI 469
Query: 1137 GMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILL 1196
G+P D SPLQVA+KTLPE+CS QDELDFLMEALIISKF HQNIVRC+G+SL++ PR ILL
Sbjct: 470 GLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILL 529
Query: 1197 ELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCL 1256
ELM+GGD+KSFLR +RP QPS L M DLL +A+DIA GC YLEENHFIHRDIAARNCL
Sbjct: 530 ELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCL 589
Query: 1257 LTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFG 1316
L+C GP RVAKIGDFGMARDIYRASYYR+G A+LPVKWMPPEAF+EGIFTSKTD+WSFG
Sbjct: 590 LSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFG 649
Query: 1317 VLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNF 1376
VLLWEIFSLGYMPYP ++NQEVL+FV GGRMDPP+ CPGPVYRIMTQCWQH+PE RP+F
Sbjct: 650 VLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSF 709
Query: 1377 AIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEER 1436
A ILER++YCTQDPDV+N+ LP+E GP EEE + + E + P Q+ E+ +
Sbjct: 710 ASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRP-PQPQELSPEKLK 768
Query: 1437 SPAAPPPLPTTSSG 1450
S P P SSG
Sbjct: 769 SWGGSPLGPWLSSG 782
>gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precursor
[Homo sapiens]
Length = 734
Score = 444 bits (1141), Expect = e-124
Identities = 214/303 (70%), Positives = 248/303 (81%), Gaps = 1/303 (0%)
Query: 1148 AVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSF 1207
+ +TLPE+CS QDELDFLMEALIISKF HQNIVRC+G+SL++ PR ILLELM+GGD+KSF
Sbjct: 412 SAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSF 471
Query: 1208 LRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAK 1267
LR +RP QPS L M DLL +A+DIA GC YLEENHFIHRDIAARNCLL+C GP RVAK
Sbjct: 472 LRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAK 531
Query: 1268 IGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGY 1327
IGDFGMARDIYRASYYR+G A+LPVKWMPPEAF+EGIFTSKTD+WSFGVLLWEIFSLGY
Sbjct: 532 IGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGY 591
Query: 1328 MPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCT 1387
MPYP ++NQEVL+FV GGRMDPP+ CPGPVYRIMTQCWQH+PE RP+FA ILER++YCT
Sbjct: 592 MPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCT 651
Query: 1388 QDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTT 1447
QDPDV+N+ LP+E GP EEE + + E + P Q+ E+ +S P P
Sbjct: 652 QDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRP-PQPQELSPEKLKSWGGSPLGPWL 710
Query: 1448 SSG 1450
SSG
Sbjct: 711 SSG 713
Score = 267 bits (682), Expect = 7e-71
Identities = 171/460 (37%), Positives = 233/460 (50%), Gaps = 85/460 (18%)
Query: 608 WLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPG 667
W Q++ W+G + + S + +L S L +P R+ P L+P
Sbjct: 4 WGQLLVWFGAAGAILCSSPG---SQETFLRSSP----LPLASPSPRDPKVSAPPSILEPA 56
Query: 668 ENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWK 727
SP +P + + WLF+TCGASG HGPTQ QC+ AY +++ V VG+ G L+G+Q+W+
Sbjct: 57 --SPLNSPGTEGS--WLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWR 112
Query: 728 VPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTN 787
VP Y IS YGAAGGKG KN + R+HGV V IF+L + LYILVGQQGEDACP +
Sbjct: 113 VPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGS 172
Query: 788 QLIQKVCIGENNVIEEEIRVNRS-----VHEWAGGGGGGGGATYVFKMKDGVPVPLIIAA 842
Q VC+GE+ +EE ++ S WAGGGGGGGGATYVF+++ G PL++AA
Sbjct: 173 PESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAA 232
Query: 843 GGGGRAYGAKTD----TFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQE 898
GGGGRAY D PE+LEN S G G GAAGG DN LWA
Sbjct: 233 GGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGDASETDN---LWA------ 283
Query: 899 GATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSF 958
G G +I ++ F
Sbjct: 284 -------------------------------DGEDGVSFIHPSSE-------------LF 299
Query: 959 ISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDG 1018
+ PL V E HGEV I+ +LNCSHC + +C E C C G LA D
Sbjct: 300 LQPLA--------VTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDN 351
Query: 1019 VSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIV 1058
V+C+ +P PL L+++VV ++ ++ L++ G++I+
Sbjct: 352 VTCM--DLHKPPGPLVLMVAVVATSTLSLLMVC--GVLIL 387
>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
Length = 2347
Score = 301 bits (772), Expect = 3e-81
Identities = 180/462 (38%), Positives = 277/462 (59%), Gaps = 38/462 (8%)
Query: 1027 PEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQ--MELQSPEYKLSKLR 1084
PE L++I+ + LV + L F + +RR + A + L + + +L++LR
Sbjct: 1858 PETSFILTIIVGIF---LVVTIPLTF----VWHRRLKNQKSAKEGVTVLINEDKELAELR 1910
Query: 1085 TSTIMTDYNPNYCFAGKT----SSISDLKEVPRKNITLIRGLGHGAFGEVYEGQ-VSGMP 1139
N C+A T I +L PR+ +TL LG GAFGEVYEG V +
Sbjct: 1911 GLAAGVGL-ANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILG 1969
Query: 1140 NDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELM 1199
++VAVKTL + ++Q++++FL EA ++SKFNH NI++ +GV L + P++I+LELM
Sbjct: 1970 VGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELM 2029
Query: 1200 AGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTC 1259
GGDL ++LR+ R L ++DL+ + DI+ GC YLE HFIHRD+AARNCL++
Sbjct: 2030 EGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSV 2089
Query: 1260 PG--PGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGV 1317
R+ KIGDFG+ARDIY+ YYRK G +LPV+WM PE+ M+GIFT+++D WSFG+
Sbjct: 2090 KDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGI 2149
Query: 1318 LLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFA 1377
L+WEI +LG+ PYP+ SN +VL +V +GGR++PP+NCP ++ +MTQCW +P+ RP F
Sbjct: 2150 LIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFH 2209
Query: 1378 IILERIE----------YCTQD----PDVINTALPIEYGPLV--EEEEKVPV---RPKDP 1418
I ++++ Y ++D VIN + E G ++ ++ +PV K+
Sbjct: 2210 RIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNR 2269
Query: 1419 EGVPPLLVSQQAKREEERSPAAPPPLPTTSSG--KAAKKPTA 1458
EG+ ++++ + + EE+S + S G K K+P A
Sbjct: 2270 EGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHA 2311
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 279 bits (714), Expect = 1e-74
Identities = 162/442 (36%), Positives = 236/442 (53%), Gaps = 37/442 (8%)
Query: 1043 ALVAALVLAFSGIMI---VYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFA 1099
AL A++L G++I V+ RK S+L + NP Y F+
Sbjct: 939 ALPVAVLLIVGGLVIMLYVFHRKRNN---------------SRLGNGVLYASVNPEY-FS 982
Query: 1100 GKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQ 1159
+ D EV R+ IT+ R LG G+FG VYEG G+ D +VA+KT+ E S +
Sbjct: 983 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMR 1042
Query: 1160 DELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPS 1219
+ ++FL EA ++ +FN ++VR +GV Q P +++ELM GDLKS+LR RP
Sbjct: 1043 ERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNP 1102
Query: 1220 SLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARD 1276
LA + ++ +A +IA G YL N F+HRD+AARNC++ KIGDFGM RD
Sbjct: 1103 VLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA---EDFTVKIGDFGMTRD 1159
Query: 1277 IYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQ 1336
IY YYRKGG +LPV+WM PE+ +G+FT+ +D WSFGV+LWEI +L PY SN+
Sbjct: 1160 IYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNE 1219
Query: 1337 EVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTA 1396
+VL FV GG +D P NCP ++ +M CWQ+ P+ RP+F I+ I+ +P +
Sbjct: 1220 QVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE-EMEPGFREVS 1278
Query: 1397 LPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSG-KAAKK 1455
+ E E++ + P++ E VP + + ++ PLP SG KA
Sbjct: 1279 FYYSEENKLPEPEELDLEPENMESVP----------LDPSASSSSLPLPDRHSGHKAENG 1328
Query: 1456 PTAAEISVRVPRGPAVEGGHVN 1477
P + +R H+N
Sbjct: 1329 PGPGVLVLRASFDERQPYAHMN 1350
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 263 bits (672), Expect = 1e-69
Identities = 133/306 (43%), Positives = 189/306 (61%), Gaps = 7/306 (2%)
Query: 1082 KLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPND 1141
K R T+ NP Y F+ + D EVPR+ I++IR LG G+FG VYEG G+
Sbjct: 946 KKRNRTLYASVNPEY-FSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAG 1004
Query: 1142 PSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAG 1201
VA+KT+ E+ S ++ ++FL EA ++ F ++VR +GV Q P +++ELM
Sbjct: 1005 EESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTR 1064
Query: 1202 GDLKSFLRETRPRPSQPSSL---AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLT 1258
GDLKS LR RP L A+ +++ +A +IA G YL N F+HRD+AARNC+++
Sbjct: 1065 GDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVS 1124
Query: 1259 CPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVL 1318
KIGDFGM RD+Y YYRKGG +LPV+WM PE+ +GIFT+ +D WSFGV+
Sbjct: 1125 ---QDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVV 1181
Query: 1319 LWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAI 1378
LWEI +L PY SN++VL+FV GG ++ + CP + +M++CWQ P RP+F
Sbjct: 1182 LWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTH 1241
Query: 1379 ILERIE 1384
IL+ I+
Sbjct: 1242 ILDSIQ 1247
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 259 bits (661), Expect = 2e-68
Identities = 159/418 (38%), Positives = 225/418 (53%), Gaps = 42/418 (10%)
Query: 1031 LPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMT 1090
+P ++ ++ + L G + ++ RK Q P+ L L S+
Sbjct: 938 VPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQ-----------PDGPLGPLYASS--- 983
Query: 1091 DYNPNYCFAGKTSSIS----DLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQ 1146
NP Y A S D EV R+ ITL+R LG G+FG VYEG + + +
Sbjct: 984 --NPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1041
Query: 1147 VAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKS 1206
VAVKT+ E S ++ ++FL EA ++ F ++VR +GV + P +++ELMA GDLKS
Sbjct: 1042 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1101
Query: 1207 FLRETRPR----PSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGP 1262
+LR RP P +P + +++ +A +IA G YL F+HRD+AARNC++
Sbjct: 1102 YLRSLRPEAENNPGRPPP-TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA---H 1157
Query: 1263 GRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEI 1322
KIGDFGM RDIY YYRKGG +LPV+WM PE+ +G+FT+ +D WSFGV+LWEI
Sbjct: 1158 DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEI 1217
Query: 1323 FSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER 1382
SL PY SN++VL+FV GG +D P NCP V +M CWQ P+ RP F I+
Sbjct: 1218 TSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNL 1277
Query: 1383 IEYCTQDPDVINTALPIEYGPLVEEEEKVP------VRPKDPEGVPPLLVSQQAKREE 1434
++ D ++ + P E EE K P + +D E V PL S +REE
Sbjct: 1278 LK------DDLHPSFP-EVSFFHSEENKAPESEELEMEFEDMENV-PLDRSSHCQREE 1327
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 259 bits (661), Expect = 2e-68
Identities = 159/418 (38%), Positives = 225/418 (53%), Gaps = 42/418 (10%)
Query: 1031 LPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMT 1090
+P ++ ++ + L G + ++ RK Q P+ L L S+
Sbjct: 950 VPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQ-----------PDGPLGPLYASS--- 995
Query: 1091 DYNPNYCFAGKTSSIS----DLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQ 1146
NP Y A S D EV R+ ITL+R LG G+FG VYEG + + +
Sbjct: 996 --NPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1053
Query: 1147 VAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKS 1206
VAVKT+ E S ++ ++FL EA ++ F ++VR +GV + P +++ELMA GDLKS
Sbjct: 1054 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1113
Query: 1207 FLRETRPR----PSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGP 1262
+LR RP P +P + +++ +A +IA G YL F+HRD+AARNC++
Sbjct: 1114 YLRSLRPEAENNPGRPPP-TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA---H 1169
Query: 1263 GRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEI 1322
KIGDFGM RDIY YYRKGG +LPV+WM PE+ +G+FT+ +D WSFGV+LWEI
Sbjct: 1170 DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEI 1229
Query: 1323 FSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER 1382
SL PY SN++VL+FV GG +D P NCP V +M CWQ P+ RP F I+
Sbjct: 1230 TSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNL 1289
Query: 1383 IEYCTQDPDVINTALPIEYGPLVEEEEKVP------VRPKDPEGVPPLLVSQQAKREE 1434
++ D ++ + P E EE K P + +D E V PL S +REE
Sbjct: 1290 LK------DDLHPSFP-EVSFFHSEENKAPESEELEMEFEDMENV-PLDRSSHCQREE 1339
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform c
precursor [Homo sapiens]
Length = 822
Score = 231 bits (589), Expect = 4e-60
Identities = 116/274 (42%), Positives = 163/274 (59%), Gaps = 10/274 (3%)
Query: 1108 LKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLME 1167
++ + R NI L R LG GAFG+V+ + + + + VAVKTL + S+ DF E
Sbjct: 530 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDA-SDNARKDFHRE 588
Query: 1168 ALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP------RPSQPSSL 1221
A +++ H++IV+ GV ++ P ++ E M GDL FLR P + P+ L
Sbjct: 589 AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 648
Query: 1222 AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRAS 1281
+LH+A+ IA G YL HF+HRD+A RNCL+ G + KIGDFGM+RD+Y
Sbjct: 649 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GENLLVKIGDFGMSRDVYSTD 705
Query: 1282 YYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEF 1341
YYR GG MLP++WMPPE+ M FT+++D WS GV+LWEIF+ G P+ SN EV+E
Sbjct: 706 YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIEC 765
Query: 1342 VTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPN 1375
+T G + P+ CP VY +M CWQ +P R N
Sbjct: 766 ITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKN 799
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform a
precursor [Homo sapiens]
Length = 838
Score = 231 bits (589), Expect = 4e-60
Identities = 116/274 (42%), Positives = 163/274 (59%), Gaps = 10/274 (3%)
Query: 1108 LKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLME 1167
++ + R NI L R LG GAFG+V+ + + + + VAVKTL + S+ DF E
Sbjct: 546 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDA-SDNARKDFHRE 604
Query: 1168 ALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP------RPSQPSSL 1221
A +++ H++IV+ GV ++ P ++ E M GDL FLR P + P+ L
Sbjct: 605 AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 664
Query: 1222 AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRAS 1281
+LH+A+ IA G YL HF+HRD+A RNCL+ G + KIGDFGM+RD+Y
Sbjct: 665 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GENLLVKIGDFGMSRDVYSTD 721
Query: 1282 YYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEF 1341
YYR GG MLP++WMPPE+ M FT+++D WS GV+LWEIF+ G P+ SN EV+E
Sbjct: 722 YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIEC 781
Query: 1342 VTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPN 1375
+T G + P+ CP VY +M CWQ +P R N
Sbjct: 782 ITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKN 815
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform 1
[Homo sapiens]
Length = 790
Score = 230 bits (587), Expect = 7e-60
Identities = 122/290 (42%), Positives = 166/290 (57%), Gaps = 12/290 (4%)
Query: 1111 VPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALI 1170
+ R++I L LG GAFG+V+ + + + + VAVK L E SE DF EA +
Sbjct: 499 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA-SESARQDFQREAEL 557
Query: 1171 ISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPS--------QPSSLA 1222
++ HQ+IVR GV + P ++ E M GDL FLR P P L
Sbjct: 558 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLG 617
Query: 1223 MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASY 1282
+ LL VA +A G YL HF+HRD+A RNCL+ G G V KIGDFGM+RDIY Y
Sbjct: 618 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYSTDY 674
Query: 1283 YRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV 1342
YR GG MLP++WMPPE+ + FT+++D WSFGV+LWEIF+ G P+ SN E ++ +
Sbjct: 675 YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI 734
Query: 1343 TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDV 1392
T G ++ P+ CP VY IM CWQ +P+ R + + R++ Q P V
Sbjct: 735 TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPV 784
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 230 bits (587), Expect = 7e-60
Identities = 122/290 (42%), Positives = 166/290 (57%), Gaps = 12/290 (4%)
Query: 1111 VPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALI 1170
+ R++I L LG GAFG+V+ + + + + VAVK L E SE DF EA +
Sbjct: 505 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA-SESARQDFQREAEL 563
Query: 1171 ISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPS--------QPSSLA 1222
++ HQ+IVR GV + P ++ E M GDL FLR P P L
Sbjct: 564 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLG 623
Query: 1223 MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASY 1282
+ LL VA +A G YL HF+HRD+A RNCL+ G G V KIGDFGM+RDIY Y
Sbjct: 624 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYSTDY 680
Query: 1283 YRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV 1342
YR GG MLP++WMPPE+ + FT+++D WSFGV+LWEIF+ G P+ SN E ++ +
Sbjct: 681 YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI 740
Query: 1343 TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDV 1392
T G ++ P+ CP VY IM CWQ +P+ R + + R++ Q P V
Sbjct: 741 TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPV 790
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform 3
[Homo sapiens]
Length = 760
Score = 230 bits (587), Expect = 7e-60
Identities = 122/290 (42%), Positives = 166/290 (57%), Gaps = 12/290 (4%)
Query: 1111 VPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALI 1170
+ R++I L LG GAFG+V+ + + + + VAVK L E SE DF EA +
Sbjct: 469 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA-SESARQDFQREAEL 527
Query: 1171 ISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPS--------QPSSLA 1222
++ HQ+IVR GV + P ++ E M GDL FLR P P L
Sbjct: 528 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLG 587
Query: 1223 MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASY 1282
+ LL VA +A G YL HF+HRD+A RNCL+ G G V KIGDFGM+RDIY Y
Sbjct: 588 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYSTDY 644
Query: 1283 YRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV 1342
YR GG MLP++WMPPE+ + FT+++D WSFGV+LWEIF+ G P+ SN E ++ +
Sbjct: 645 YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI 704
Query: 1343 TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDV 1392
T G ++ P+ CP VY IM CWQ +P+ R + + R++ Q P V
Sbjct: 705 TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPV 754
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 227 bits (578), Expect = 8e-59
Identities = 132/379 (34%), Positives = 203/379 (53%), Gaps = 33/379 (8%)
Query: 1029 PHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTI 1088
P +++I+S+++S + L L + + RRK Q + +S L+ L + +
Sbjct: 490 PTYSMTVIISIMSSFAIFVL-LTITTLYCCRRRK----QWKNKKRESAAVTLTTLPSELL 544
Query: 1089 MTDYNPNYCFAGKTSSISDLK---EVPRKNITLIRGLGHGAFGEVYEGQVSGM-PNDPSP 1144
+ +PN + ++ E PR NI +R +G GAFG V++ + G+ P +P
Sbjct: 545 LDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFT 604
Query: 1145 LQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDL 1204
+ VAVK L E S + DF EA ++++F++ NIV+ +GV P +L E MA GDL
Sbjct: 605 M-VAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDL 663
Query: 1205 KSFLRETRPRP-----------------SQPSSLAMLDLLHVARDIACGCQYLEENHFIH 1247
FLR P P L+ + L +AR +A G YL E F+H
Sbjct: 664 NEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVH 723
Query: 1248 RDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFT 1307
RD+A RNCL+ G V KI DFG++R+IY A YY+ +P++WMPPE+ +T
Sbjct: 724 RDLATRNCLV---GENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYT 780
Query: 1308 SKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQ 1367
+++D W++GV+LWEIFS G PY +++EV+ +V G + P+NCP +Y +M CW
Sbjct: 781 TESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWS 840
Query: 1368 HQPEDRPNFAI---ILERI 1383
P DRP+F ILER+
Sbjct: 841 KLPADRPSFTSIHRILERM 859
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform b
precursor [Homo sapiens]
Length = 825
Score = 223 bits (568), Expect = 1e-57
Identities = 121/296 (40%), Positives = 169/296 (57%), Gaps = 19/296 (6%)
Query: 1093 NPNYCFAGKTSSISD--LKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVK 1150
NP Y G D ++ + R++I L R LG GAFG+V+ + + + VAVK
Sbjct: 513 NPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVK 572
Query: 1151 TL--PEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFL 1208
L P + + +D F EA +++ H++IV+ GV P ++ E M GDL FL
Sbjct: 573 ALKDPTLAARKD---FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 629
Query: 1209 RETRP--------RPSQPSS-LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTC 1259
R P +P Q L + +LH+A IA G YL HF+HRD+A RNCL+
Sbjct: 630 RAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV-- 687
Query: 1260 PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLL 1319
G + KIGDFGM+RD+Y YYR GG MLP++WMPPE+ M FT+++D WSFGV+L
Sbjct: 688 -GANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVIL 746
Query: 1320 WEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPN 1375
WEIF+ G P+ SN EV+E +T G ++ P+ CP VY +M CWQ +P+ R N
Sbjct: 747 WEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLN 802
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 220 bits (561), Expect = 8e-57
Identities = 116/271 (42%), Positives = 163/271 (60%), Gaps = 14/271 (5%)
Query: 1114 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK 1173
+++ L +G G FGEV+ G++ VAVK+ E + FL EA I+ +
Sbjct: 431 EDLVLGEQIGRGNFGEVFSGRLRA-----DNTLVAVKSCRETLPPDLKAKFLQEARILKQ 485
Query: 1174 FNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDI 1233
++H NIVR IGV Q P +I++EL+ GGD +FLR ++ + L + LL + D
Sbjct: 486 YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR------TEGARLRVKTLLQMVGDA 539
Query: 1234 ACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPV 1293
A G +YLE IHRD+AARNCL+T V KI DFGM+R+ Y GG +PV
Sbjct: 540 AAGMEYLESKCCIHRDLAARNCLVT---EKNVLKISDFGMSREEADGVYAASGGLRQVPV 596
Query: 1294 KWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKN 1353
KW PEA G ++S++D WSFG+LLWE FSLG PYP+ SNQ+ EFV GGR+ P+
Sbjct: 597 KWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPEL 656
Query: 1354 CPGPVYRIMTQCWQHQPEDRPNFAIILERIE 1384
CP V+R+M QCW ++P RP+F+ I + ++
Sbjct: 657 CPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 687
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 220 bits (561), Expect = 8e-57
Identities = 116/271 (42%), Positives = 163/271 (60%), Gaps = 14/271 (5%)
Query: 1114 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK 1173
+++ L +G G FGEV+ G++ VAVK+ E + FL EA I+ +
Sbjct: 489 EDLVLGEQIGRGNFGEVFSGRLRA-----DNTLVAVKSCRETLPPDLKAKFLQEARILKQ 543
Query: 1174 FNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDI 1233
++H NIVR IGV Q P +I++EL+ GGD +FLR ++ + L + LL + D
Sbjct: 544 YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR------TEGARLRVKTLLQMVGDA 597
Query: 1234 ACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPV 1293
A G +YLE IHRD+AARNCL+T V KI DFGM+R+ Y GG +PV
Sbjct: 598 AAGMEYLESKCCIHRDLAARNCLVT---EKNVLKISDFGMSREEADGVYAASGGLRQVPV 654
Query: 1294 KWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKN 1353
KW PEA G ++S++D WSFG+LLWE FSLG PYP+ SNQ+ EFV GGR+ P+
Sbjct: 655 KWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPEL 714
Query: 1354 CPGPVYRIMTQCWQHQPEDRPNFAIILERIE 1384
CP V+R+M QCW ++P RP+F+ I + ++
Sbjct: 715 CPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 745
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 220 bits (561), Expect = 8e-57
Identities = 116/271 (42%), Positives = 163/271 (60%), Gaps = 14/271 (5%)
Query: 1114 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK 1173
+++ L +G G FGEV+ G++ VAVK+ E + FL EA I+ +
Sbjct: 501 EDLVLGEQIGRGNFGEVFSGRLRA-----DNTLVAVKSCRETLPPDLKAKFLQEARILKQ 555
Query: 1174 FNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDI 1233
++H NIVR IGV Q P +I++EL+ GGD +FLR ++ + L + LL + D
Sbjct: 556 YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR------TEGARLRVKTLLQMVGDA 609
Query: 1234 ACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPV 1293
A G +YLE IHRD+AARNCL+T V KI DFGM+R+ Y GG +PV
Sbjct: 610 AAGMEYLESKCCIHRDLAARNCLVT---EKNVLKISDFGMSREEADGVYAASGGLRQVPV 666
Query: 1294 KWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKN 1353
KW PEA G ++S++D WSFG+LLWE FSLG PYP+ SNQ+ EFV GGR+ P+
Sbjct: 667 KWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPEL 726
Query: 1354 CPGPVYRIMTQCWQHQPEDRPNFAIILERIE 1384
CP V+R+M QCW ++P RP+F+ I + ++
Sbjct: 727 CPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 757
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 220 bits (561), Expect = 8e-57
Identities = 116/271 (42%), Positives = 163/271 (60%), Gaps = 14/271 (5%)
Query: 1114 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK 1173
+++ L +G G FGEV+ G++ VAVK+ E + FL EA I+ +
Sbjct: 559 EDLVLGEQIGRGNFGEVFSGRLRA-----DNTLVAVKSCRETLPPDLKAKFLQEARILKQ 613
Query: 1174 FNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDI 1233
++H NIVR IGV Q P +I++EL+ GGD +FLR ++ + L + LL + D
Sbjct: 614 YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR------TEGARLRVKTLLQMVGDA 667
Query: 1234 ACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPV 1293
A G +YLE IHRD+AARNCL+T V KI DFGM+R+ Y GG +PV
Sbjct: 668 AAGMEYLESKCCIHRDLAARNCLVT---EKNVLKISDFGMSREEADGVYAASGGLRQVPV 724
Query: 1294 KWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKN 1353
KW PEA G ++S++D WSFG+LLWE FSLG PYP+ SNQ+ EFV GGR+ P+
Sbjct: 725 KWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPEL 784
Query: 1354 CPGPVYRIMTQCWQHQPEDRPNFAIILERIE 1384
CP V+R+M QCW ++P RP+F+ I + ++
Sbjct: 785 CPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 815
>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
Length = 885
Score = 218 bits (555), Expect = 4e-56
Identities = 134/382 (35%), Positives = 203/382 (53%), Gaps = 42/382 (10%)
Query: 1039 VVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCF 1098
V+ A+VAA + + +V+RRK + E+ P + +L + Y +
Sbjct: 444 VLLGAVVAAACVLILALFLVHRRKKETRYG---EVFEPTVERGEL-----VVRYRVRKSY 495
Query: 1099 AGKTSSIS--------DLKE------VPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSP 1144
+ +T+ + +LKE V R + L + LG G FG V EGQ++ D S
Sbjct: 496 SRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN---QDDSI 552
Query: 1145 LQVAVKTLP-EVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPR------FILLE 1197
L+VAVKT+ +C+ + DFL EA+ + +F+H N++R IGV Q R ++L
Sbjct: 553 LKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILP 612
Query: 1198 LMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLL 1257
M GDL SFL +R QP L L+ DIA G +YL FIHRD+AARNC+L
Sbjct: 613 FMKHGDLHSFLLYSR-LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCML 671
Query: 1258 TCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGV 1317
+ DFG+++ IY YYR+G A +PVKW+ E+ + ++TSK+D WSFGV
Sbjct: 672 N---ENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGV 728
Query: 1318 LLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFA 1377
+WEI + G PYP N E+ +++ G R+ P +C +Y +M++CW+ P+DRP+F
Sbjct: 729 TMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFT 788
Query: 1378 IILERIEYC------TQDPDVI 1393
+ E +E Q+PD I
Sbjct: 789 ELREDLENTLKALPPAQEPDEI 810
>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
Length = 894
Score = 218 bits (555), Expect = 4e-56
Identities = 134/382 (35%), Positives = 203/382 (53%), Gaps = 42/382 (10%)
Query: 1039 VVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCF 1098
V+ A+VAA + + +V+RRK + E+ P + +L + Y +
Sbjct: 453 VLLGAVVAAACVLILALFLVHRRKKETRYG---EVFEPTVERGEL-----VVRYRVRKSY 504
Query: 1099 AGKTSSIS--------DLKE------VPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSP 1144
+ +T+ + +LKE V R + L + LG G FG V EGQ++ D S
Sbjct: 505 SRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN---QDDSI 561
Query: 1145 LQVAVKTLP-EVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPR------FILLE 1197
L+VAVKT+ +C+ + DFL EA+ + +F+H N++R IGV Q R ++L
Sbjct: 562 LKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILP 621
Query: 1198 LMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLL 1257
M GDL SFL +R QP L L+ DIA G +YL FIHRD+AARNC+L
Sbjct: 622 FMKHGDLHSFLLYSR-LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCML 680
Query: 1258 TCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGV 1317
+ DFG+++ IY YYR+G A +PVKW+ E+ + ++TSK+D WSFGV
Sbjct: 681 N---ENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGV 737
Query: 1318 LLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFA 1377
+WEI + G PYP N E+ +++ G R+ P +C +Y +M++CW+ P+DRP+F
Sbjct: 738 TMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFT 797
Query: 1378 IILERIEYC------TQDPDVI 1393
+ E +E Q+PD I
Sbjct: 798 ELREDLENTLKALPPAQEPDEI 819
>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform a
precursor [Homo sapiens]
Length = 839
Score = 213 bits (543), Expect = 9e-55
Identities = 121/310 (39%), Positives = 169/310 (54%), Gaps = 33/310 (10%)
Query: 1093 NPNYCFAGKTSSISD--LKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVK 1150
NP Y G D ++ + R++I L R LG GAFG+V+ + + + VAVK
Sbjct: 513 NPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVK 572
Query: 1151 TL--PEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFL 1208
L P + + +D F EA +++ H++IV+ GV P ++ E M GDL FL
Sbjct: 573 ALKDPTLAARKD---FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 629
Query: 1209 RETRP--------RPSQPSS-LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTC 1259
R P +P Q L + +LH+A IA G YL HF+HRD+A RNCL+
Sbjct: 630 RAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV-- 687
Query: 1260 PGPGRVAKIGDFGMARDIYRASYYRK--------------GGCAMLPVKWMPPEAFMEGI 1305
G + KIGDFGM+RD+Y YYR GG MLP++WMPPE+ M
Sbjct: 688 -GANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRK 746
Query: 1306 FTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQC 1365
FT+++D WSFGV+LWEIF+ G P+ SN EV+E +T G ++ P+ CP VY +M C
Sbjct: 747 FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGC 806
Query: 1366 WQHQPEDRPN 1375
WQ +P+ R N
Sbjct: 807 WQREPQQRLN 816
>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
[Homo sapiens]
Length = 808
Score = 211 bits (538), Expect = 4e-54
Identities = 119/311 (38%), Positives = 172/311 (55%), Gaps = 21/311 (6%)
Query: 1110 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPS--PLQVAVKTLPEVCSEQDELDFLME 1167
E+ R +TL + LG G FG+V + G+ D + P+ VAVK L + +++D D + E
Sbjct: 468 ELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSE 527
Query: 1168 ALIISKFN-HQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP----------RPS 1216
++ H+NI+ +G Q P ++L+E A G+L+ FLR RP +P
Sbjct: 528 MEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPP 587
Query: 1217 QPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARD 1276
+ L DL+ A +A G +YL IHRD+AARN L+T V KI DFG+ARD
Sbjct: 588 E-EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVT---EDNVMKIADFGLARD 643
Query: 1277 IYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQ 1336
++ YY+K LPVKWM PEA + ++T ++D WSFGVLLWEIF+LG PYP +
Sbjct: 644 VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVE 703
Query: 1337 EVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAII---LERIEYCTQDPDVI 1393
E+ + + G RMD P NC +Y IM +CW P RP F + L+R+ T + +
Sbjct: 704 ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYL 763
Query: 1394 NTALPIE-YGP 1403
+ + P E Y P
Sbjct: 764 DLSAPFEQYSP 774
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 211 bits (538), Expect = 4e-54
Identities = 119/311 (38%), Positives = 172/311 (55%), Gaps = 21/311 (6%)
Query: 1110 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPS--PLQVAVKTLPEVCSEQDELDFLME 1167
E+ R +TL + LG G FG+V + G+ D + P+ VAVK L + +++D D + E
Sbjct: 354 ELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSE 413
Query: 1168 ALIISKFN-HQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP----------RPS 1216
++ H+NI+ +G Q P ++L+E A G+L+ FLR RP +P
Sbjct: 414 MEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPP 473
Query: 1217 QPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARD 1276
+ L DL+ A +A G +YL IHRD+AARN L+T V KI DFG+ARD
Sbjct: 474 E-EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVT---EDNVMKIADFGLARD 529
Query: 1277 IYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQ 1336
++ YY+K LPVKWM PEA + ++T ++D WSFGVLLWEIF+LG PYP +
Sbjct: 530 VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVE 589
Query: 1337 EVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAII---LERIEYCTQDPDVI 1393
E+ + + G RMD P NC +Y IM +CW P RP F + L+R+ T + +
Sbjct: 590 ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYL 649
Query: 1394 NTALPIE-YGP 1403
+ + P E Y P
Sbjct: 650 DLSAPFEQYSP 660
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 211 bits (538), Expect = 4e-54
Identities = 119/311 (38%), Positives = 172/311 (55%), Gaps = 21/311 (6%)
Query: 1110 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPS--PLQVAVKTLPEVCSEQDELDFLME 1167
E+ R +TL + LG G FG+V + G+ D + P+ VAVK L + +++D D + E
Sbjct: 466 ELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSE 525
Query: 1168 ALIISKFN-HQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP----------RPS 1216
++ H+NI+ +G Q P ++L+E A G+L+ FLR RP +P
Sbjct: 526 MEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPP 585
Query: 1217 QPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARD 1276
+ L DL+ A +A G +YL IHRD+AARN L+T V KI DFG+ARD
Sbjct: 586 E-EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVT---EDNVMKIADFGLARD 641
Query: 1277 IYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQ 1336
++ YY+K LPVKWM PEA + ++T ++D WSFGVLLWEIF+LG PYP +
Sbjct: 642 VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVE 701
Query: 1337 EVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAII---LERIEYCTQDPDVI 1393
E+ + + G RMD P NC +Y IM +CW P RP F + L+R+ T + +
Sbjct: 702 ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYL 761
Query: 1394 NTALPIE-YGP 1403
+ + P E Y P
Sbjct: 762 DLSAPFEQYSP 772
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 211 bits (538), Expect = 4e-54
Identities = 115/285 (40%), Positives = 165/285 (57%), Gaps = 24/285 (8%)
Query: 1101 KTSSISDLKEVPR--------KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL 1152
K S + L +P+ +++ L LG G FGEVY+G + + VAVKT
Sbjct: 540 KKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTS------VAVKTC 593
Query: 1153 PEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETR 1212
E ++ ++ FL EA I+ +++H NIV+ IGV Q P +I++EL++GGD +FLR +
Sbjct: 594 KEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKK 653
Query: 1213 PRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFG 1272
L + L+ + D A G YLE + IHRD+AARNCL+ G V KI DFG
Sbjct: 654 ------DELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLV---GENNVLKISDFG 704
Query: 1273 MARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS 1332
M+R Y G +P+KW PEA G ++S++D WSFG+LLWE FSLG PYP
Sbjct: 705 MSRQ-EDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPG 763
Query: 1333 KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFA 1377
+NQ+ E V G RM P++CP + +IM +CW ++PE+RP F+
Sbjct: 764 MTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFS 808
>gi|134152725 receptor tyrosine kinase-like orphan receptor 1 isoform
1 [Homo sapiens]
Length = 937
Score = 210 bits (535), Expect = 8e-54
Identities = 126/358 (35%), Positives = 188/358 (52%), Gaps = 25/358 (6%)
Query: 1036 ILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPN 1095
IL ++ ++ L +A I R +Q+ + ++ Q P++ + +++ Y P
Sbjct: 404 ILYILVPSVAIPLAIALLFFFICVCRNNQKSSSAPVQRQ-PKHVRGQNVEMSMLNAYKPK 462
Query: 1096 YCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEV 1155
S KE+P + + LG AFG++Y+G + +P VA+KTL +
Sbjct: 463 ----------SKAKELPLSAVRFMEELGECAFGKIYKGHLY-LPGMDHAQLVAIKTLKDY 511
Query: 1156 CSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRP 1215
+ Q +F EA ++++ +H NIV +G Q P +L E + GDL FL P
Sbjct: 512 NNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHS 571
Query: 1216 ----------SQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRV 1265
+ SSL D LH+A IA G +YL + F+H+D+AARN L+ G
Sbjct: 572 DVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILI---GEQLH 628
Query: 1266 AKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSL 1325
KI D G++R+IY A YYR ++LP++WMPPEA M G F+S +D WSFGV+LWEIFS
Sbjct: 629 VKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSF 688
Query: 1326 GYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI 1383
G PY SNQEV+E V + ++CP +Y +MT+CW P RP F I R+
Sbjct: 689 GLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRL 746
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 210 bits (535), Expect = 8e-54
Identities = 124/381 (32%), Positives = 207/381 (54%), Gaps = 25/381 (6%)
Query: 1026 TPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRR--KHQELQAMQMELQSPEYKL--- 1080
+P P+ + I V +A+ A ++A G+M ++ K + LQ Q E + PE +
Sbjct: 695 SPPPYKMIQTIGLSVGAAV--AYIIAVLGLMFYCKKRCKAKRLQK-QPEGEEPEMECLNG 751
Query: 1081 ---------SKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVY 1131
++++ +T K S SD PR ++ I LG FGEV+
Sbjct: 752 GPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVF 811
Query: 1132 EGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLP 1191
+ G+ + V VK+L EQ +LDF E + K NH N+VR +G+ ++ P
Sbjct: 812 LAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEP 870
Query: 1192 RFILLELMAGGDLKSFLRETRPRPSQPSS--LAMLDLLHVARDIACGCQYLEENHFIHRD 1249
+++LE + GDLK FLR ++ + + S L+ + + +A G ++L N F+H+D
Sbjct: 871 HYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKD 930
Query: 1250 IAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSK 1309
+AARNCL++ R K+ G+++D+Y + YY A +P++WM PEA +EG F++K
Sbjct: 931 LAARNCLVSAQ---RQVKVSALGLSKDVYNSEYYHFRQ-AWVPLRWMSPEAILEGDFSTK 986
Query: 1310 TDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSG-GRMDPPKNCPGPVYRIMTQCWQH 1368
+D W+FGVL+WE+F+ G MP+ +++ EVL + +G R+ P+ CP +YR+M +CW
Sbjct: 987 SDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAL 1046
Query: 1369 QPEDRPNFAIILERIEYCTQD 1389
P+DRP+F+ I + T D
Sbjct: 1047 SPKDRPSFSEIASALGDSTVD 1067
>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
sapiens]
Length = 1014
Score = 210 bits (535), Expect = 8e-54
Identities = 124/381 (32%), Positives = 207/381 (54%), Gaps = 25/381 (6%)
Query: 1026 TPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRR--KHQELQAMQMELQSPEYKL--- 1080
+P P+ + I V +A+ A ++A G+M ++ K + LQ Q E + PE +
Sbjct: 639 SPPPYKMIQTIGLSVGAAV--AYIIAVLGLMFYCKKRCKAKRLQK-QPEGEEPEMECLNG 695
Query: 1081 ---------SKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVY 1131
++++ +T K S SD PR ++ I LG FGEV+
Sbjct: 696 GPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVF 755
Query: 1132 EGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLP 1191
+ G+ + V VK+L EQ +LDF E + K NH N+VR +G+ ++ P
Sbjct: 756 LAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEP 814
Query: 1192 RFILLELMAGGDLKSFLRETRPRPSQPSS--LAMLDLLHVARDIACGCQYLEENHFIHRD 1249
+++LE + GDLK FLR ++ + + S L+ + + +A G ++L N F+H+D
Sbjct: 815 HYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKD 874
Query: 1250 IAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSK 1309
+AARNCL++ R K+ G+++D+Y + YY A +P++WM PEA +EG F++K
Sbjct: 875 LAARNCLVSAQ---RQVKVSALGLSKDVYNSEYYHFRQ-AWVPLRWMSPEAILEGDFSTK 930
Query: 1310 TDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSG-GRMDPPKNCPGPVYRIMTQCWQH 1368
+D W+FGVL+WE+F+ G MP+ +++ EVL + +G R+ P+ CP +YR+M +CW
Sbjct: 931 SDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAL 990
Query: 1369 QPEDRPNFAIILERIEYCTQD 1389
P+DRP+F+ I + T D
Sbjct: 991 SPKDRPSFSEIASALGDSTVD 1011
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,035,581
Number of Sequences: 37866
Number of extensions: 3976103
Number of successful extensions: 27878
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 449
Number of HSP's successfully gapped in prelim test: 558
Number of HSP's that attempted gapping in prelim test: 18330
Number of HSP's gapped (non-prelim): 4925
length of query: 1620
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1504
effective length of database: 13,855,062
effective search space: 20838013248
effective search space used: 20838013248
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.