Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 28460688
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28460688 taxilin [Homo sapiens]
(546 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28460688 taxilin [Homo sapiens] 1077 0.0
gi|8922940 gamma-taxilin [Homo sapiens] 493 e-139
gi|222537714 taxilin beta [Homo sapiens] 483 e-136
gi|14211893 lipopolysaccaride-specific response 5-like protein [... 142 1e-33
gi|58530840 desmoplakin isoform I [Homo sapiens] 84 4e-16
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 82 1e-15
gi|71061468 centromere protein E [Homo sapiens] 82 1e-15
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 82 2e-15
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 82 2e-15
gi|7705415 hook homolog 1 [Homo sapiens] 81 2e-15
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 78 2e-14
gi|221219020 NYD-SP11 protein [Homo sapiens] 78 2e-14
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 78 2e-14
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 77 4e-14
gi|148746195 trichohyalin [Homo sapiens] 76 7e-14
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 76 9e-14
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 75 1e-13
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 75 2e-13
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 74 3e-13
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 74 4e-13
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 74 4e-13
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 74 4e-13
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 73 6e-13
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 73 8e-13
gi|55770834 centromere protein F [Homo sapiens] 73 8e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 72 1e-12
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 72 1e-12
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 72 1e-12
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 72 1e-12
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 72 1e-12
>gi|28460688 taxilin [Homo sapiens]
Length = 546
Score = 1077 bits (2785), Expect = 0.0
Identities = 546/546 (100%), Positives = 546/546 (100%)
Query: 1 MKNQDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQA 60
MKNQDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQA
Sbjct: 1 MKNQDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQA 60
Query: 61 RTAQSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARN 120
RTAQSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARN
Sbjct: 61 RTAQSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARN 120
Query: 121 GEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLN 180
GEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLN
Sbjct: 121 GEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLN 180
Query: 181 TLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSK 240
TLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSK
Sbjct: 181 TLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSK 240
Query: 241 LESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQ 300
LESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQ
Sbjct: 241 LESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQ 300
Query: 301 ENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKD 360
ENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKD
Sbjct: 301 ENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKD 360
Query: 361 FLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTK 420
FLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTK
Sbjct: 361 FLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTK 420
Query: 421 KIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERND 480
KIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERND
Sbjct: 421 KIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERND 480
Query: 481 LNKRVQDLSAGGQGSLTDSGPERRPEGPGAQAPSSPRVTEAPCYPGAPSTEASGQTGPQE 540
LNKRVQDLSAGGQGSLTDSGPERRPEGPGAQAPSSPRVTEAPCYPGAPSTEASGQTGPQE
Sbjct: 481 LNKRVQDLSAGGQGSLTDSGPERRPEGPGAQAPSSPRVTEAPCYPGAPSTEASGQTGPQE 540
Query: 541 PTSARA 546
PTSARA
Sbjct: 541 PTSARA 546
>gi|8922940 gamma-taxilin [Homo sapiens]
Length = 528
Score = 493 bits (1269), Expect = e-139
Identities = 269/463 (58%), Positives = 338/463 (73%), Gaps = 16/463 (3%)
Query: 28 EGAQERPSQAAPAVEAEGPGSSQAPRKPE--GAQARTAQSGALRDVSEELSRQLEDILST 85
E A+ R A A EA G ++PR+ G G + Q DIL
Sbjct: 7 EAARGRGGGAEEATEAGRGGRRRSPRQKFEIGTMEEAGICGLGVKADMLCNSQSNDILQH 66
Query: 86 YCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEI 145
+N GG + E + ++R V+ P +E G E
Sbjct: 67 Q--GSNCGGTSNKHSLEEDEGSDFITENRNLVS------PAYCTQESREEIPGG----EA 114
Query: 146 RQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRN 205
R G +D + K+K LGKE+ LLMQ LNTLSTPEEKLAALCKKYA+LLEE R+
Sbjct: 115 RTDPPDGQQDSECNRNKEKT--LGKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRS 172
Query: 206 SQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRARE 265
QKQMK+LQKKQ+Q+V+EK HL+ EHSKA+LARSKLESLCRELQRHN++LKEE +Q+ARE
Sbjct: 173 VQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEENMQQARE 232
Query: 266 EEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDK 325
EEE+RKE T+HFQ+TL++IQ Q+EQH+ N+KLRQEN+EL E+LKKLIEQY LREEHIDK
Sbjct: 233 EEERRKEATAHFQITLDEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDK 292
Query: 326 VFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQ 385
VFK K+LQQQLVDAKLQQ +++KEA+E+HQRE++FLLKEA ES+ E MKQQE LKQ
Sbjct: 293 VFKRKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQ 352
Query: 386 QLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLE 445
QL+LY +KFEEFQ T++KS+E+FTTF+QEMEKMTKKIKKLEKET ++R++WE++NKALL+
Sbjct: 353 QLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQ 412
Query: 446 MAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDL 488
MAEEKTVRDKE + LQ+K++RLEKLCRALQTERN+LN++V+ L
Sbjct: 413 MAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVL 455
>gi|222537714 taxilin beta [Homo sapiens]
Length = 684
Score = 483 bits (1242), Expect = e-136
Identities = 265/506 (52%), Positives = 353/506 (69%), Gaps = 32/506 (6%)
Query: 3 NQDKKNGAAKQSNPKSSPGQPEAGPE--GAQERPSQAAPAVEAEGPGSSQAPRKPEGAQA 60
N ++ A +QS P PG + P G ++ Q + P Q P K
Sbjct: 4 NHSEQLSAERQSTP---PGDSSSLPSHNGLEKEDGQ-------DSPTPVQPPEK------ 47
Query: 61 RTAQSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARN 120
++ D+SEEL+RQLEDI++TY + G++G+ +PE+AE +
Sbjct: 48 ---EASVHPDISEELNRQLEDIINTY--GSAASTAGKEGSARASEQPENAESPDN---ED 99
Query: 121 GEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLN 180
G+ E T G + + G+P T + + V +++ + EKK KGLGKE LLMQ LN
Sbjct: 100 GDCEETTEEAGREPVASGEPPTVK----EPVSNKEQKL--EKKILKGLGKEANLLMQNLN 153
Query: 181 TLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSK 240
L TPEEK L KKYAELL+EHR QK++KLLQKKQ Q+ +EKD L+GEHS+A+LARSK
Sbjct: 154 KLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSK 213
Query: 241 LESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQ 300
LESLCRELQRHN++LKEE +QRAREEEEKRKE+TSHFQ TL DIQ Q+EQ +ERN KL Q
Sbjct: 214 LESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQ 273
Query: 301 ENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKD 360
EN ELAE+LK +I+QYELREEH+DK+FKH++LQQ+LVDAKL+QAQEM+KEAEERH+REK+
Sbjct: 274 ENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKE 333
Query: 361 FLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTK 420
+LL +A E + +++K+QET L+ QL LY+ +FEEFQ+TL+KS+EVF TFKQEM+K TK
Sbjct: 334 YLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTK 393
Query: 421 KIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERND 480
K+KKLEK+T +++R+E+ NKALL+M EEK +R KE E +KI RLE LCRALQ ERN+
Sbjct: 394 KMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNE 453
Query: 481 LNKRVQDLSAGGQGSLTDSGPERRPE 506
L+K+++D + + + PE
Sbjct: 454 LHKKIRDAEISEKDDQSQHNSDEEPE 479
>gi|14211893 lipopolysaccaride-specific response 5-like protein
[Homo sapiens]
Length = 181
Score = 142 bits (357), Expect = 1e-33
Identities = 78/174 (44%), Positives = 109/174 (62%), Gaps = 19/174 (10%)
Query: 376 MKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSR 435
MKQ+E LK+QL LY +KFEEFQ T++K++E+FT FKQE EK+TKKIKKLEKE ++ ++
Sbjct: 1 MKQEEAQLKEQLFLYMDKFEEFQTTMAKTNELFTAFKQETEKLTKKIKKLEKEMVIWYTK 60
Query: 436 WESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRV---------- 485
WE++N LL+MAEEKT+RDK + Q+K++RLEKL +ALQ ERN+L++++
Sbjct: 61 WENNNTTLLQMAEEKTIRDKNYKVFQIKLERLEKLYKALQIERNELSEKLGILKGQVSVK 120
Query: 486 ---QDLSAGGQGSLTDSGPER-----RPEGPGAQAPSSPR-VTEAPCYPGAPST 530
DL+ S D PG + P+ + E CY A ST
Sbjct: 121 VADVDLAVPVTHSCADLDSSNMLNTSSKRAPGVHLEADPKGMNEVKCYSKALST 174
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 83.6 bits (205), Expect = 4e-16
Identities = 110/460 (23%), Positives = 198/460 (43%), Gaps = 67/460 (14%)
Query: 106 EPEDAEKSRT-YVARNGEPEPTPVVNG----EKEPSKGDPNTEEIRQSDEVGDRDHRRPQ 160
E E+A R Y + T +N E+E ++ + E + Q V D+D R Q
Sbjct: 1501 EDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQ 1560
Query: 161 EKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKL-------- 212
K L K+ + + LN L + + KK E LE R S K+ +
Sbjct: 1561 NSLKELQLQKQ--KVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQ 1618
Query: 213 -----LQKKQSQ--LVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSL--KEEGVQRA 263
+ KK+S+ L Q++D L G + + +L L E++ R L ++E V++A
Sbjct: 1619 LEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQA 1678
Query: 264 REEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYE-LR--- 319
E ++ +LN+ ++++E+ L +E++ L E L+ L +Y+ LR
Sbjct: 1679 HLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGR 1738
Query: 320 -EEHIDK------------VFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEA 366
E DK + ++ L+ Q + LQ+ +E L++ E+ Q++
Sbjct: 1739 SEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRI 1798
Query: 367 VESQRMCELMKQQETHLKQQLALYTE------KFEEFQNTLSKSSEVFTTFKQEMEKMTK 420
ES+ C + Q+ L ++ + + + E+ N + E T KQ +E +
Sbjct: 1799 QESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQ 1858
Query: 421 KIKK-LEKETTMYRSRWESSNKALLEMAEEKTVRDK-----ELEGLQVKIQRLEKLCR-- 472
+I+ L + T Y + E+ K +E EK+ R+K E+E LQ +I+R+E+ CR
Sbjct: 1859 QIQNDLNQWKTQYSRKEEAIRK--IESEREKSEREKNSLRSEIERLQAEIKRIEERCRRK 1916
Query: 473 ----------ALQTERNDLNKRVQDLSAGGQGSLTDSGPE 502
L+TER+ + + L GS ++ E
Sbjct: 1917 LEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE 1956
Score = 55.8 bits (133), Expect = 1e-07
Identities = 73/355 (20%), Positives = 156/355 (43%), Gaps = 51/355 (14%)
Query: 143 EEIRQSDEVGDRDHRRPQE-----KKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYA 197
E+I+Q G +R Q+ ++ + +E Q+L+ + + ++
Sbjct: 1428 EDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLK 1487
Query: 198 ELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKE 257
+L+++ N +K L+ + ++L + + L+ +S A +KL+ +EL R L+
Sbjct: 1488 QLIDKETNDRK---CLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTR----LRI 1540
Query: 258 EGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYE 317
+ + ++E K +++T FQ +L ++QLQ ++ E ++L++ E + + KKL E+ E
Sbjct: 1541 DYERVSQERTVKDQDIT-RFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELE 1599
Query: 318 -LREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELM 376
+R ++ K +L QQL +QA + K +E+ ++++D L
Sbjct: 1600 GMRRSLKEQAIKITNLTQQL-----EQASIVKKRSEDDLRQQRDVL-------------- 1640
Query: 377 KQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRW 436
+ HL+++ ++ E E+E + +++ + ++ R
Sbjct: 1641 ---DGHLREK---------------QRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRN 1682
Query: 437 ESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLSAG 491
E KA+ + + E+E LQ + L K L+ E +L DL G
Sbjct: 1683 EHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRG 1737
Score = 53.1 bits (126), Expect = 6e-07
Identities = 66/333 (19%), Positives = 146/333 (43%), Gaps = 44/333 (13%)
Query: 188 KLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHS--KAVLARSKLESLC 245
++ L +K L E + +++ K ++ + Q + D L+ K L KLES
Sbjct: 1103 QIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEK 1162
Query: 246 R------ELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQH-NERNSKL 298
E++R L+EEG R RE E + +V +H+ +++++ + E N + +
Sbjct: 1163 AIKEKEYEIERLRVLLQEEGT-RKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTI 1221
Query: 299 RQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQRE 358
++ +M+ + K L Q + +++DL+ ++V + + + +A E+ +R
Sbjct: 1222 KEISMQKEDDSKNLRNQLDRLSR------ENRDLKDEIV-----RLNDSILQATEQRRRA 1270
Query: 359 KDFLLKEAVESQRMCELMKQQETHLKQQL-------ALYTEKFEEFQNTLSKSSEVFTTF 411
++ L++ + + + E LKQ + A + + EE T+ ++
Sbjct: 1271 EENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERL 1330
Query: 412 KQEMEKMTKKIKKLEKETTMYRSRWES-----SNKALLEMAEEKTV-------RDKELEG 459
K E ++ K+ + E E + R+ ++ N+ E+ KT ++++ G
Sbjct: 1331 KAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSG 1390
Query: 460 LQVKIQRLEKLCRALQTE----RNDLNKRVQDL 488
+ +I L + R+L E +N L + ++L
Sbjct: 1391 YRAQIDNLTRENRSLSEEIKRLKNTLTQTTENL 1423
Score = 53.1 bits (126), Expect = 6e-07
Identities = 64/337 (18%), Positives = 151/337 (44%), Gaps = 43/337 (12%)
Query: 160 QEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQ 219
Q++ +K L ++ L + L ++++ L + E+ R +++ + S+
Sbjct: 1227 QKEDDSKNLRNQLDRLSRENRDL---KDEIVRLNDSILQATEQRRRAEENALQQKACGSE 1283
Query: 220 LVQEKDHLRGEHSKAVLARSK--------LESLCRELQRHNRSLK------EEGVQRARE 265
++Q+K HL E + + RS+ LE + +Q N+ ++ +E +R E
Sbjct: 1284 IMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWE 1343
Query: 266 EEEKRKEVTSHFQVTLNDIQLQMEQH-NERNSKLRQENMELAERLKKLIEQYELREEHID 324
E + +V +++ + ++ Q E N + + Q M+ E Y + +++
Sbjct: 1344 YENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSG----YRAQIDNLT 1399
Query: 325 KVFKHKDLQQQLVDAK--LQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETH 382
+ +++ L +++ K L Q E L+ EE Q++K + + +Q E
Sbjct: 1400 R--ENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK-------ATGSEVSQRKQQLEVE 1450
Query: 383 LKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKK-------LEKETT-MYRS 434
L+Q + TE+ ++ +L +++ +E+E++ + I K LE E + R
Sbjct: 1451 LRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRV 1510
Query: 435 RW--ESSNKALLEMAEEKTVRDKELEGLQVKIQRLEK 469
++ + +N + E + V+++EL L++ +R+ +
Sbjct: 1511 QYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQ 1547
Score = 44.3 bits (103), Expect = 3e-04
Identities = 77/351 (21%), Positives = 152/351 (43%), Gaps = 55/351 (15%)
Query: 144 EIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALC----KKYAEL 199
++ Q E + H R + +KA I ++LN E+L +L K++ L
Sbjct: 1667 QLLQEQESVKQAHLRNEHFQKA------IEDKSRSLNESKIEIERLQSLTENLTKEHLML 1720
Query: 200 LEEHRNSQKQMKLLQKKQSQLVQEKD----HLRGEHSKAVLARSKLESLCRELQRHNRSL 255
EE RN + + L++ +S+ +K+ LR + + +L+ L +LQR +L
Sbjct: 1721 EEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENL 1780
Query: 256 KEE----------GVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQE---- 301
++E R +E + + +V + L I++ +EQ R +L E
Sbjct: 1781 RQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKV-LEQDKARLQRLEDELNRA 1839
Query: 302 --NMELAERLKKLIE---------------QYELREEHIDKVFKHK---DLQQQLVDAKL 341
+E R+K+ +E QY +EE I K+ + + ++ + +++
Sbjct: 1840 KSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEI 1899
Query: 342 QQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQE--THLKQQ-LALYTEKFEEFQ 398
++ Q +K EER +R+ + +E +SQ E + Q L+Q+ + E E +
Sbjct: 1900 ERLQAEIKRIEERCRRKLEDSTRE-TQSQLETERSRYQREIDKLRQRPYGSHRETQTECE 1958
Query: 399 NTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEE 449
T+ S VF ++++ M +L +TT+ + K++ E+A E
Sbjct: 1959 WTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTL--DKLLKGKKSVEEVASE 2007
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 82.0 bits (201), Expect = 1e-15
Identities = 122/535 (22%), Positives = 224/535 (41%), Gaps = 84/535 (15%)
Query: 14 SNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGP---GSSQAPRKPEGAQARTAQSGALRD 70
S+PKS G G + R S+ V+ P G+ + ++P G + + + +
Sbjct: 403 SDPKSFHGLDF----GFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDE 458
Query: 71 VSEELSRQLEDILSTYCVDNNQG-------GPGEDGAQGEPAEPE----------DAEKS 113
+ + S+ LE+ LS + E+ QG +PE A
Sbjct: 459 LQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASL 518
Query: 114 RTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGD-RDHRRPQEKKKAKGLGKEI 172
++ E P+P P+ + E+ Q++E+G ++ E+K A +
Sbjct: 519 SLQLSLQREQAPSP-------PAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPV 571
Query: 173 TLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHS 232
+ +++ ++ PE+ A K E + + Q Q LL+ KQ ++ Q ++ L E
Sbjct: 572 SPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLE-QDQRHLLESKQEKMQQLREKLCQEEE 630
Query: 233 KAVLA--RSKLESLCRELQRHNRSLKEEGVQRAREEEEK----RKEVTSHFQVTLNDIQL 286
+ +L + K +SL +R ++++EE + EE ++ R +V S Q + I+
Sbjct: 631 EEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRA 690
Query: 287 QME------------QHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQ 334
+ E Q + L Q+N ++ E+LK+ IE E E+ K K LQQ
Sbjct: 691 EQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQ 750
Query: 335 ---QLVDAKLQQAQEMLKE-----------AEERHQREKDFLLKEAVESQRMCELMKQ-- 378
QL + + + KE E +H+ L K+ E+Q+ E Q
Sbjct: 751 LREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKC 810
Query: 379 --QETHLKQQLALYTEKFEEFQNTL--SKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRS 434
Q H Q + + +E ++L K EV ++ ++KM K E + M ++
Sbjct: 811 LGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKM-----KEEHQQVMAKA 865
Query: 435 RWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLC-RALQTERNDLNKRVQDL 488
R + AEE+ R + L L +++RL++ R L+T R + +KR++DL
Sbjct: 866 REQYE-------AEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDL 913
Score = 62.8 bits (151), Expect = 8e-10
Identities = 96/415 (23%), Positives = 173/415 (41%), Gaps = 59/415 (14%)
Query: 31 QERPSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLEDILSTYCVDN 90
+E SQ + A+ S+QA Q R Q +L+ + EEL Q + ++ N
Sbjct: 663 REEESQRLSWLRAQVQSSTQADED----QIRAEQEASLQKLREELESQQKAERASLEQKN 718
Query: 91 NQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDE 150
Q + E E +EKS +N KE + +++R+ E
Sbjct: 719 RQM------LEQLKEEIEASEKSEQ-----------AALNAAKEKA-----LQQLREQLE 756
Query: 151 VGDRDHRRPQEKKKAKGLGKEITLLMQTL-NTLSTPEEKLAALCKKYAELLEEHRNSQKQ 209
G+R K+ L KE + ++ L ++L ++ + +K + ++ +Q Q
Sbjct: 757 -GER-------KEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQ 808
Query: 210 MKLLQKKQSQLVQEKDHLRG-EHSKAVLARSKLESLCRELQRHNRSLKEEGVQ---RARE 265
K L + + ++ Q+ H+ G EH + L R K + + E +R +KEE Q +ARE
Sbjct: 809 -KCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKARE 867
Query: 266 --EEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHI 323
E E+RK+ +++ H +RQE + E L++ + E + + +
Sbjct: 868 QYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDL 927
Query: 324 DKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLL----------KEAVESQRMC 373
+ DL+ + D K + A +L+ EE +REK LL +EA + +
Sbjct: 928 E-----LDLETRAKDVKARLA--LLEVQEETARREKQQLLDVQRQVALKSEEATATHQQL 980
Query: 374 ELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKE 428
E +++ THL Q E +E Q K + + +++ K LE E
Sbjct: 981 EEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAE 1035
Score = 48.1 bits (113), Expect = 2e-05
Identities = 75/315 (23%), Positives = 129/315 (40%), Gaps = 51/315 (16%)
Query: 154 RDHRRPQEKK----------KAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEH 203
R R QE+K +AK + + LL T +++L + ++ A EE
Sbjct: 914 RRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEA 973
Query: 204 RNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLES-------LCRELQRHNRSLK 256
+ +Q++ QK+ + L+Q LR + + KLES ++LQ+H SL+
Sbjct: 974 TATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLE 1033
Query: 257 EEGVQR---AREEEEKRKEVTSHFQVTLN--DIQ--LQMEQHNERNSKLRQENMELAERL 309
E ++ RE + + HF+ L+ D++ L Q E +S L Q +L
Sbjct: 1034 AEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDL---- 1089
Query: 310 KKLIEQYELREEHIDKVFKHKDLQQQLVDAK---LQQAQEMLKEAEERHQREKDFLLKEA 366
++D + H L+ A+ L+ A+E L + + R R + LK A
Sbjct: 1090 ------------YLDSLSSHN--VWHLLSAEGVALRSAKEFLVQ-QTRSMRRRQTALKAA 1134
Query: 367 VESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLE 426
+ R EL QE K + + E+ + L K + K M K +KK E
Sbjct: 1135 QQHWRH-ELASAQEV-AKDPPGI--KALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKE 1190
Query: 427 KETTMYRSR-WESSN 440
++ S WE ++
Sbjct: 1191 EKLNQLESSLWEEAS 1205
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 82.0 bits (201), Expect = 1e-15
Identities = 92/414 (22%), Positives = 183/414 (44%), Gaps = 41/414 (9%)
Query: 109 DAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGL 168
D E+ V E +VN KE K D + ++ E+ + ++ ++ +
Sbjct: 828 DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKT--ELSYKTQELQEKTREVQER 885
Query: 169 GKEITLLMQTL----NTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEK 224
E+ L + L +TL T E + + +K + LEE + ++ L++ Q L E+
Sbjct: 886 LNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIER 945
Query: 225 DHLRGEHSKAV--------LARSKLESLCRELQRHN--RSLKEEGVQRAREEEEKRKEVT 274
D L+ + V R+ LESL + + N +S E V R EE E
Sbjct: 946 DQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETK 1005
Query: 275 SHFQVTLNDIQLQ--MEQHNERNSKLRQENMELAERLKK---LIEQYELREEHIDKVFKH 329
FQ + I + +E N + ++ E+ E+ +K LI++ ++ ++ V
Sbjct: 1006 DEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAE 1065
Query: 330 K-----DLQQQLVDAKLQQAQEM------LKEAEERHQREKDFLLKEAVESQRMCELMKQ 378
K DL++ ++ ++ +E+ LK+ +E +EK+ +K+ E R C+ + +
Sbjct: 1066 KEQLKTDLKEN-IEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAE 1124
Query: 379 QETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWES 438
E LK++ EK ++ N + SE M+K +I+ L+ E E
Sbjct: 1125 VEEKLKEKSQQLQEKQQQLLNVQEEMSE--------MQKKINEIENLKNELKNKELTLEH 1176
Query: 439 SNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLSAGG 492
LE+A++ +E++ + + + L++L ++ +TER+ L ++++ A G
Sbjct: 1177 METERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG 1230
Score = 67.0 bits (162), Expect = 4e-11
Identities = 84/397 (21%), Positives = 180/397 (45%), Gaps = 61/397 (15%)
Query: 108 EDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKG 167
+D EKS T + E PV++ E+E PN +E+ ++ E +
Sbjct: 1269 QDLEKSHTKLQ-----EEIPVLHEEQELL---PNVKEVSETQETMN-------------- 1306
Query: 168 LGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHL 227
E+ LL + T + LA + + L E+ + SQ+++K L K++ L K+ L
Sbjct: 1307 ---ELELLTEQSTTKDSTT--LARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEAL 1361
Query: 228 RGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQ 287
+H + + + ++Q ++S +E+ + ++ E K V+ +
Sbjct: 1362 EVKHDQL---KEHIRETLAKIQE-SQSKQEQSLNMKEKDNETTKIVS------------E 1405
Query: 288 MEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKD-LQ--QQLVDAKLQQA 344
MEQ ++S L + +E+ K+L E ++ + V K KD LQ Q+++ ++ Q
Sbjct: 1406 MEQFKPKDSALLRIEIEMLGLSKRLQESHD----EMKSVAKEKDDLQRLQEVLQSESDQL 1461
Query: 345 QEMLKEAEERHQREKDFL------LKEAVESQRMCEL-MKQQETHL---KQQLALYTEKF 394
+E +KE +H ++ L LKE E+ + + ++ET + ++QL +K
Sbjct: 1462 KENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKL 1521
Query: 395 EEFQNTLSKSSEVFTTFK-QEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVR 453
+ + + E F + E+++ ++K+ ++ S +S +LE+
Sbjct: 1522 QNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQES 1581
Query: 454 DKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLSA 490
+E++ + + + ++++ ALQ ER+ L + +++ A
Sbjct: 1582 QEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVA 1618
Score = 59.3 bits (142), Expect = 9e-09
Identities = 83/348 (23%), Positives = 154/348 (44%), Gaps = 40/348 (11%)
Query: 141 NTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLN-TLSTPEEKLAALCKKYAEL 199
N EE+R + +RD R E+ L E L + L T++ EK L + L
Sbjct: 1677 NLEEMRSVTK--ERDDLRSVEET----LKVERDQLKENLRETITRDLEKQEELKIVHMHL 1730
Query: 200 LEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEG 259
E K ++ +K +++ + L EHS L L+ + EL+ + LKE+
Sbjct: 1731 KEHQETIDKLRGIVSEKTNEISNMQKDL--EHSNDALKAQDLK-IQEELRIAHMHLKEQ- 1786
Query: 260 VQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELR 319
+E +K + + S L+++Q +E N +KL+++ EL +LI +
Sbjct: 1787 ----QETIDKLRGIVSEKTDKLSNMQKDLENSN---AKLQEKIQELKANEHQLITLKKDV 1839
Query: 320 EEHIDKVFKHKDLQQQLVDAKLQQAQ---EMLKEAEERHQR--EKDFLLKEAVESQRMCE 374
E KV + + L++Q+ D L ++ E L A++ H+ E ++KE +R+ E
Sbjct: 1840 NETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEE 1899
Query: 375 LMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRS 434
+K + LK+ L + E Q L + + K+ ++K+ +KI
Sbjct: 1900 TLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKI------------ 1947
Query: 435 RWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLN 482
++ +++++ + DK + LQ KIQ L+K L + D+N
Sbjct: 1948 -----SEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVN 1990
Score = 59.3 bits (142), Expect = 9e-09
Identities = 86/355 (24%), Positives = 158/355 (44%), Gaps = 50/355 (14%)
Query: 170 KEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHR----NSQKQMKLLQKKQSQLVQEKD 225
+E+ +M+ + L EE L + E L+E + Q+++K + + + D
Sbjct: 1882 EEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVD 1941
Query: 226 HLRGEHSKAVLARSK----LESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVT- 280
LR + S+ + S L+ ELQ+ + L+++ +Q R +E+ SH ++
Sbjct: 1942 KLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNM---SHKKINE 1998
Query: 281 LNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAK 340
+ ++ Q E N +R +N +L ++L + +E+ + + D++ + K+ + D
Sbjct: 1999 MEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQF 2058
Query: 341 LQQAQEMLKEAEERHQ--REKDFL------LKEAVESQ--RMCELMK---QQETHLK--Q 385
+ +EM+ + HQ EK L L E++ + R+ EL+K + + H +
Sbjct: 2059 IATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLN 2118
Query: 386 QLALYTEKFEEFQNTLS--------------KSSEVFTTFKQ----EMEKMTKKIK-KLE 426
+L+L EK EFQ LS K E T Q E ++ KK+K L
Sbjct: 2119 RLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLS 2178
Query: 427 KETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDL 481
T + + ES NK ++ +E + KE L +KIQ L++ C E DL
Sbjct: 2179 YVTKIKEEQHESINKFEMDFIDE-VEKQKE---LLIKIQHLQQDCDVPSRELRDL 2229
Score = 58.9 bits (141), Expect = 1e-08
Identities = 77/362 (21%), Positives = 160/362 (44%), Gaps = 25/362 (6%)
Query: 137 KGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTL-------NTLSTPEEKL 189
K D E IR++ + ++ K E T ++ + + L E ++
Sbjct: 1364 KHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEM 1423
Query: 190 AALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQ 249
L K+ E +E ++ K+ LQ+ Q L E D L+ E+ K ++A+ LE+ EL+
Sbjct: 1424 LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLK-ENIKEIVAKH-LETE-EELK 1480
Query: 250 RHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERL 309
+ LKE+ E + + S + ++ IQ Q+E N++ QE E E+
Sbjct: 1481 VAHCCLKEQ-----EETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQF 1535
Query: 310 K-KLIEQYELREEHIDKVFKH---KDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKE 365
K I + + + + + +H KD Q +++K+ + L+E++E Q ++KE
Sbjct: 1536 NIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ----IMIKE 1591
Query: 366 AVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKL 425
E +R+ E ++ + LK+ K +E Q + ++ T + EKM +I+ L
Sbjct: 1592 KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKM-TAVNETQEKMC-EIEHL 1649
Query: 426 EKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRV 485
+++ + E+ + + + +E+ + + L + L+ ER+ L + +
Sbjct: 1650 KEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENL 1709
Query: 486 QD 487
++
Sbjct: 1710 RE 1711
Score = 55.8 bits (133), Expect = 1e-07
Identities = 65/316 (20%), Positives = 148/316 (46%), Gaps = 27/316 (8%)
Query: 186 EEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAV-LARSKL--E 242
+EK+ L Y ++ + + Q Q++ +K Q L +E E +K L K+ +
Sbjct: 652 KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKD 711
Query: 243 SLCR-ELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQE 301
LC EL+ L++E + E E R+EV + L++++ + ER LR+E
Sbjct: 712 LLCNLELEGKITDLQKELNKEVEENEALREEV-----ILLSELK-SLPSEVER---LRKE 762
Query: 302 NMELAERLKKLI-EQYELREEHIDKVFKHKDLQQQLVDAK--LQQAQEMLKEAEERHQRE 358
+ +E L + E+ +L E + K + + L +++ K L Q K ++ Q
Sbjct: 763 IQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNF 822
Query: 359 KDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKM 418
K + + ++ +++ ++ + Q++ +++ ++F ++L + QE+++
Sbjct: 823 KTLHM----DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEK 878
Query: 419 TKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQR-------LEKLC 471
T+++++ E + + E+ + L + EKT+ ++L+ +++ L++L
Sbjct: 879 TREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQ 938
Query: 472 RALQTERNDLNKRVQD 487
+LQ ER+ L + D
Sbjct: 939 ESLQIERDQLKSDIHD 954
Score = 52.8 bits (125), Expect = 8e-07
Identities = 79/369 (21%), Positives = 145/369 (39%), Gaps = 65/369 (17%)
Query: 194 KKYAELLEEHRNSQKQMKLLQKK-----QSQLVQEKDHLRG--EH-------------SK 233
K+ EL + +N + + L++K + QL+ E +L+ +H SK
Sbjct: 521 KEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSK 580
Query: 234 AVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNE 293
L R K E ++LQ + S K E ++ + E + TL D +
Sbjct: 581 VELLREK-EDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKR 639
Query: 294 RNSKLRQENMELAERLKKLIEQYELREEHID------------KVFKHKDLQQ------- 334
++ LR EN+EL E++K+L Y+ E I +V K+LQ
Sbjct: 640 ESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITK 699
Query: 335 --QLVDAKLQQ---------------AQEMLKEAEERHQ-REKDFLLKEAVESQRMCELM 376
L+D K+ + +E+ KE EE RE+ LL E E +
Sbjct: 700 LTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERL 759
Query: 377 KQQETHLKQQLALYT-EKFEEFQNTLSKSSEV------FTTFKQEMEKMTKKIKKLEKET 429
+++ ++L + T EK + F + K S V K ++ K ++E
Sbjct: 760 RKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEF 819
Query: 430 TMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLS 489
+++ + + EE ++E+ L + Q+ + AL+TE + + +Q+ +
Sbjct: 820 QNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKT 879
Query: 490 AGGQGSLTD 498
Q L +
Sbjct: 880 REVQERLNE 888
Score = 37.0 bits (84), Expect = 0.046
Identities = 53/229 (23%), Positives = 96/229 (41%), Gaps = 33/229 (14%)
Query: 270 RKEVTSHFQVTLN---DIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKV 326
RKE+T + LN DI+ + N ++ Q N R+ ++ + EE +
Sbjct: 2265 RKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATI 2324
Query: 327 FKHKDLQQQLVDAKLQQAQEMLKEAEER----HQREKDFLLKEAVESQRMCELMKQQETH 382
K + +Q + LKE E+ +Q K L A + + T
Sbjct: 2325 SK-----------EWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTS 2373
Query: 383 LKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKA 442
QL TEK E +N+L ++ E + ++ KM K+++ +++ SNK
Sbjct: 2374 RATQLT--TEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKC 2431
Query: 443 LLEMAEE-KTVRDK----------ELEGLQVKIQR--LEKLCRALQTER 478
L + E + ++DK E+E L++K+ + LEK+ A + E+
Sbjct: 2432 LEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEK 2480
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 81.6 bits (200), Expect = 2e-15
Identities = 97/454 (21%), Positives = 208/454 (45%), Gaps = 49/454 (10%)
Query: 49 SQAPRKPEGAQARTAQSGALRDVSEE---LSRQLEDILSTYCVDNNQGGPGEDGAQGEPA 105
S+AP+K G + S L + E L++ +E++ +T D +G +
Sbjct: 443 SEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTV-----------DSVEGNAS 491
Query: 106 EPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDR--DHRRPQEKK 163
+ EK +++ E +V ++ ++++ + ++ + R ++
Sbjct: 492 KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551
Query: 164 KAKGLGKEITLLMQTLNTLS-----TPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQS 218
+ K L +E L QT+++L + E ++ + K+ L E + + ++ ++ ++
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR 611
Query: 219 QLVQEKDHLRGEHSKAVLARSKLESLCRE---LQRHNRSLKE-----EGVQRAREEEEKR 270
Q+ +E +H + + +A ++L L +E LQ+ +LK E +++ E E+
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
Query: 271 KEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKL----IEQYELREEHIDKV 326
+ ++ Q+E + NS+L +EN+EL ++ L ++ +L+ E+
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN---- 727
Query: 327 FKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQ 386
K+L+ + +L++ E+LK + ++ +R + +E+QR+ + ++ + QQ
Sbjct: 728 ---KELESE--KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI-QQ 781
Query: 387 LALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMY---RSRWESSNKAL 443
L + E TL K+ E + +E++ K+ K LE+ET+ + + E NK L
Sbjct: 782 LESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
Query: 444 LEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTE 477
+ AE ++D LE VKI LEK + L E
Sbjct: 842 RQQAE---IKDTTLEENNVKIGNLEKENKTLSKE 872
Score = 73.6 bits (179), Expect = 4e-13
Identities = 96/394 (24%), Positives = 178/394 (45%), Gaps = 43/394 (10%)
Query: 132 EKEPSKGDPNTEEIRQSDE-VGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLA 190
EKE S+ D E+R++ E + + Q + + K L E L + L L +K
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 191 ALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHS--KAVLARSKLESL-CRE 247
L Y L E++ QK ++ KK QL E L E+ + L K+ S +
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ 812
Query: 248 LQRHNRSLKEEGVQRAREEEEKRKEVTS-HFQVTLNDIQLQMEQHNERNSKLRQENMELA 306
L++ N+SL++E Q +++++ KE Q + D L E++N + L +EN L+
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL--EENNVKIGNLEKENKTLS 870
Query: 307 ERL----KKLIEQYELREEHIDKVFKHK-------DLQQQLVDAKLQQAQEMLKEAEE-R 354
+ + + + EL +E+ + V + L++ LV KL+ Q+M + E+
Sbjct: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK-TQQMNNDLEKLT 929
Query: 355 HQREKDFLLKE-------AVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEV 407
H+ EK L KE + + R L + E+ LK+ L + EK + L +S+
Sbjct: 930 HELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 989
Query: 408 FTTFKQEMEKMTKK---IKKLEKETTMYRS---------RWE----SSNKALLEMAEEKT 451
+QE++ + K +K+ + E M +S +WE + + LL++ +
Sbjct: 990 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1049
Query: 452 VRDKELEGLQVKIQRLEKLCRALQTERNDLNKRV 485
++ LQ + Q L+ + L+T+ N+L ++
Sbjct: 1050 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1083
Score = 64.3 bits (155), Expect = 3e-10
Identities = 88/374 (23%), Positives = 161/374 (43%), Gaps = 57/374 (15%)
Query: 132 EKEPSKGDPNTEEIRQS-DEVGDRDHRRPQEKKKAKGLGKEITLL----------MQTLN 180
E E EE+R + D V + + +K+ + L K++ +L +Q
Sbjct: 466 EMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ 525
Query: 181 TLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSK 240
LS K A +K E L E NS++Q+K+L+++ L Q LR + A ++
Sbjct: 526 NLSKDLMKEKAQLEKTIETLRE--NSERQIKILEQENEHLNQTVSSLR--QRSQISAEAR 581
Query: 241 LESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQ 300
++ + +E + + S+KE + ++ E EKR+ I+ ++E + E+
Sbjct: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQ------------IKKELEHYKEKG----- 624
Query: 301 ENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKD 360
E AE L+ + E E + K + + + ++A Q+ E+ ER R+
Sbjct: 625 ---ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSEL-----ERENRK-- 674
Query: 361 FLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTK 420
LK+ ++S + L Q E+ K+ L E E L ++ E +M ++
Sbjct: 675 --LKKTLDSFK--NLTFQLESLEKENSQLDEENLE-----LRRNVESLKCASMKMAQLQL 725
Query: 421 KIKKLEKETTMYRSRWESSNKALLEMAEEKTVR-DKELEGLQVKIQRLEKLCRALQTERN 479
+ K+LE E + E LL+ + +KT R + +GL ++ QRL+K +
Sbjct: 726 ENKELESEKEQLKKGLE-----LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 480 DLNKRVQDLSAGGQ 493
L +QDL Q
Sbjct: 781 QLESELQDLEMENQ 794
Score = 52.0 bits (123), Expect = 1e-06
Identities = 85/364 (23%), Positives = 157/364 (43%), Gaps = 68/364 (18%)
Query: 162 KKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLV 221
K + + L ++ +L++T L E A K EL +K+ L+ K +
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHEL-------EKENLQLKAKLHDME 395
Query: 222 QEKDHLRGEHSKAVLARSKLESLCRE---LQRHNRSLKEEGVQRAREEEE--KRKEVTSH 276
E+D + R K+E L E L+ + +E + E E+ + E++
Sbjct: 396 MERD----------MDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEA 445
Query: 277 FQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKD----- 331
Q +L ++ + R KL EN L + +++L + E + K+ K +
Sbjct: 446 PQKSLGHEVNELT--SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503
Query: 332 ------LQQQLVDAK--LQQAQEMLKEA-EERHQREKDF-LLKEAVESQRMCELMKQQET 381
L+ ++V K LQ Q + K+ +E+ Q EK L+E S+R ++++Q+
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE--NSERQIKILEQENE 561
Query: 382 HLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNK 441
HL Q ++ ++ + +S + V +++EK K + + KET+ S+ E +
Sbjct: 562 HLNQTVSSLRQRSQ-----ISAEARV-----KDIEKENKILHESIKETSSKLSKIEFEKR 611
Query: 442 AL---LEMAEEKTVRDKELEG-----------LQVKIQRLEKLC---RALQTERNDLNKR 484
+ LE +EK R +ELE LQ KI L+ C AL+ E ++L +
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
Query: 485 VQDL 488
+ L
Sbjct: 672 NRKL 675
Score = 49.7 bits (117), Expect = 7e-06
Identities = 46/181 (25%), Positives = 90/181 (49%), Gaps = 22/181 (12%)
Query: 313 IEQYELREEHIDKVFKHKDLQ-QQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQR 371
+E ++ +E I+ + K+ L ++L+D + + ++ +++ +EER FL + +Q
Sbjct: 176 MEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH--FLPHASSSAQS 233
Query: 372 MCEL--MKQQET--HLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEK 427
C MK+ E+ HL +LA K + L + +E KQE+E+M ++K+L++
Sbjct: 234 PCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ 293
Query: 428 ETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQD 487
E N LL A + EL+ L+ K R++K L++E + +R+ D
Sbjct: 294 E-----------NMNLLSDARSARMYRDELDALREKAVRVDK----LESEVSRYKERLHD 338
Query: 488 L 488
+
Sbjct: 339 I 339
Score = 42.0 bits (97), Expect = 0.001
Identities = 61/361 (16%), Positives = 137/361 (37%), Gaps = 29/361 (8%)
Query: 64 QSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEP 123
Q +L + +E + ++ ED+ S Y +D + E A + + ++++G
Sbjct: 1131 QQSSLENENESVIKEREDLKSLY------DSLIKDHEKLELLHERQASEYESLISKHGTL 1184
Query: 124 EPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLS 183
+ + D + ++Q ++ D + E++K K + L
Sbjct: 1185 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1244
Query: 184 TPEEKL----AALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARS 239
++L + L K+ L +H+N + + + +Q++L E L+ ++ + + +
Sbjct: 1245 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1304
Query: 240 KLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLR 299
KL + C L + +L+EE + + Q + + +EQ+ E
Sbjct: 1305 KLNNQCELLSQLKGNLEEEN-----------RHLLDQIQTLMLQNRTLLEQNMESKDLFH 1353
Query: 300 QENMELAERLKKLIEQYELREEHIDKVFKHKD-----LQQQLVDAKLQQAQEMLKEAEER 354
E + ++L +L Q E EE I +K D + + K+++ + K+
Sbjct: 1354 VEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRE 1413
Query: 355 HQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQE 414
Q+ + S+ +L Q + ++ + E+ Q +K S Q
Sbjct: 1414 RQKSLTLTPTRSDSSEGFLQLPHQDS---QDSSSVGSNSLEDGQTLGTKKSSTMNDLVQS 1470
Query: 415 M 415
M
Sbjct: 1471 M 1471
Score = 41.2 bits (95), Expect = 0.002
Identities = 52/262 (19%), Positives = 112/262 (42%), Gaps = 34/262 (12%)
Query: 256 KEEGVQRAREEE-EKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENME-----LAERL 309
KEE ++R + + + + V +H Q ++ + + + + QE++E +A L
Sbjct: 138 KEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHL 197
Query: 310 KKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVES 369
K+LI++ + E I ++ + +D L A AQ + + L E ++
Sbjct: 198 KRLIDERDEHSETIIELSEERDGLHFLPHAS-SSAQSPCGSPGMKRTESRQHLSVELADA 256
Query: 370 QRMCELMKQQETHLKQQLALYTEKFEEFQ-----------NTLS--KSSEVFTTFKQEME 416
+ ++Q+ +QL ++ E+ + N LS +S+ ++ +
Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316
Query: 417 KMTKKIKKLEKETTMYRSRWESSN--KALLE--------MAEEKTVRDKELEGLQVKIQR 466
+ ++ KLE E + Y+ R KA +E + E KT+ + +LEG + + +
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDK 376
Query: 467 LEKLCRALQTERNDLNKRVQDL 488
L + L+ E L ++ D+
Sbjct: 377 LHE----LEKENLQLKAKLHDM 394
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 81.6 bits (200), Expect = 2e-15
Identities = 97/454 (21%), Positives = 208/454 (45%), Gaps = 49/454 (10%)
Query: 49 SQAPRKPEGAQARTAQSGALRDVSEE---LSRQLEDILSTYCVDNNQGGPGEDGAQGEPA 105
S+AP+K G + S L + E L++ +E++ +T D +G +
Sbjct: 443 SEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTV-----------DSVEGNAS 491
Query: 106 EPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDR--DHRRPQEKK 163
+ EK +++ E +V ++ ++++ + ++ + R ++
Sbjct: 492 KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551
Query: 164 KAKGLGKEITLLMQTLNTLS-----TPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQS 218
+ K L +E L QT+++L + E ++ + K+ L E + + ++ ++ ++
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR 611
Query: 219 QLVQEKDHLRGEHSKAVLARSKLESLCRE---LQRHNRSLKE-----EGVQRAREEEEKR 270
Q+ +E +H + + +A ++L L +E LQ+ +LK E +++ E E+
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
Query: 271 KEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKL----IEQYELREEHIDKV 326
+ ++ Q+E + NS+L +EN+EL ++ L ++ +L+ E+
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN---- 727
Query: 327 FKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQ 386
K+L+ + +L++ E+LK + ++ +R + +E+QR+ + ++ + QQ
Sbjct: 728 ---KELESE--KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI-QQ 781
Query: 387 LALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMY---RSRWESSNKAL 443
L + E TL K+ E + +E++ K+ K LE+ET+ + + E NK L
Sbjct: 782 LESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
Query: 444 LEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTE 477
+ AE ++D LE VKI LEK + L E
Sbjct: 842 RQQAE---IKDTTLEENNVKIGNLEKENKTLSKE 872
Score = 72.4 bits (176), Expect = 1e-12
Identities = 96/393 (24%), Positives = 177/393 (45%), Gaps = 42/393 (10%)
Query: 132 EKEPSKGDPNTEEIRQSDE-VGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLA 190
EKE S+ D E+R++ E + + Q + + K L E L + L L +K
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 191 ALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHS--KAVLARSKLESL-CRE 247
L Y L E++ QK ++ KK QL E L E+ + L K+ S +
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ 812
Query: 248 LQRHNRSLKEEGVQRAREEEEKRKEVTS-HFQVTLNDIQLQMEQHNERNSKLRQENMELA 306
L++ N+SL++E Q +++++ KE Q + D L E++N + L +EN L+
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL--EENNVKIGNLEKENKTLS 870
Query: 307 ERL----KKLIEQYELREEHIDKVFKHK-------DLQQQLVDAKLQQAQEMLKEAEE-R 354
+ + + + EL +E+ + V + L++ LV KL+ Q+M + E+
Sbjct: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK-TQQMNNDLEKLT 929
Query: 355 HQREKDFLLKEAV------ESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVF 408
H+ EK L KE + R L + E+ LK+ L + EK + L +S+
Sbjct: 930 HELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN 989
Query: 409 TTFKQEMEKMTKK---IKKLEKETTMYRS---------RWE----SSNKALLEMAEEKTV 452
+QE++ + K +K+ + E M +S +WE + + LL++ +
Sbjct: 990 QQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1049
Query: 453 RDKELEGLQVKIQRLEKLCRALQTERNDLNKRV 485
++ LQ + Q L+ + L+T+ N+L ++
Sbjct: 1050 VERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1082
Score = 64.3 bits (155), Expect = 3e-10
Identities = 88/374 (23%), Positives = 161/374 (43%), Gaps = 57/374 (15%)
Query: 132 EKEPSKGDPNTEEIRQS-DEVGDRDHRRPQEKKKAKGLGKEITLL----------MQTLN 180
E E EE+R + D V + + +K+ + L K++ +L +Q
Sbjct: 466 EMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ 525
Query: 181 TLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSK 240
LS K A +K E L E NS++Q+K+L+++ L Q LR + A ++
Sbjct: 526 NLSKDLMKEKAQLEKTIETLRE--NSERQIKILEQENEHLNQTVSSLR--QRSQISAEAR 581
Query: 241 LESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQ 300
++ + +E + + S+KE + ++ E EKR+ I+ ++E + E+
Sbjct: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQ------------IKKELEHYKEKG----- 624
Query: 301 ENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKD 360
E AE L+ + E E + K + + + ++A Q+ E+ ER R+
Sbjct: 625 ---ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSEL-----ERENRK-- 674
Query: 361 FLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTK 420
LK+ ++S + L Q E+ K+ L E E L ++ E +M ++
Sbjct: 675 --LKKTLDSFK--NLTFQLESLEKENSQLDEENLE-----LRRNVESLKCASMKMAQLQL 725
Query: 421 KIKKLEKETTMYRSRWESSNKALLEMAEEKTVR-DKELEGLQVKIQRLEKLCRALQTERN 479
+ K+LE E + E LL+ + +KT R + +GL ++ QRL+K +
Sbjct: 726 ENKELESEKEQLKKGLE-----LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 480 DLNKRVQDLSAGGQ 493
L +QDL Q
Sbjct: 781 QLESELQDLEMENQ 794
Score = 52.0 bits (123), Expect = 1e-06
Identities = 85/364 (23%), Positives = 157/364 (43%), Gaps = 68/364 (18%)
Query: 162 KKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLV 221
K + + L ++ +L++T L E A K EL +K+ L+ K +
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHEL-------EKENLQLKAKLHDME 395
Query: 222 QEKDHLRGEHSKAVLARSKLESLCRE---LQRHNRSLKEEGVQRAREEEE--KRKEVTSH 276
E+D + R K+E L E L+ + +E + E E+ + E++
Sbjct: 396 MERD----------MDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEA 445
Query: 277 FQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKD----- 331
Q +L ++ + R KL EN L + +++L + E + K+ K +
Sbjct: 446 PQKSLGHEVNELT--SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503
Query: 332 ------LQQQLVDAK--LQQAQEMLKEA-EERHQREKDF-LLKEAVESQRMCELMKQQET 381
L+ ++V K LQ Q + K+ +E+ Q EK L+E S+R ++++Q+
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE--NSERQIKILEQENE 561
Query: 382 HLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNK 441
HL Q ++ ++ + +S + V +++EK K + + KET+ S+ E +
Sbjct: 562 HLNQTVSSLRQRSQ-----ISAEARV-----KDIEKENKILHESIKETSSKLSKIEFEKR 611
Query: 442 AL---LEMAEEKTVRDKELEG-----------LQVKIQRLEKLC---RALQTERNDLNKR 484
+ LE +EK R +ELE LQ KI L+ C AL+ E ++L +
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
Query: 485 VQDL 488
+ L
Sbjct: 672 NRKL 675
Score = 49.7 bits (117), Expect = 7e-06
Identities = 46/181 (25%), Positives = 90/181 (49%), Gaps = 22/181 (12%)
Query: 313 IEQYELREEHIDKVFKHKDLQ-QQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQR 371
+E ++ +E I+ + K+ L ++L+D + + ++ +++ +EER FL + +Q
Sbjct: 176 MEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH--FLPHASSSAQS 233
Query: 372 MCEL--MKQQET--HLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEK 427
C MK+ E+ HL +LA K + L + +E KQE+E+M ++K+L++
Sbjct: 234 PCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ 293
Query: 428 ETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQD 487
E N LL A + EL+ L+ K R++K L++E + +R+ D
Sbjct: 294 E-----------NMNLLSDARSARMYRDELDALREKAVRVDK----LESEVSRYKERLHD 338
Query: 488 L 488
+
Sbjct: 339 I 339
Score = 41.2 bits (95), Expect = 0.002
Identities = 52/262 (19%), Positives = 112/262 (42%), Gaps = 34/262 (12%)
Query: 256 KEEGVQRAREEE-EKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENME-----LAERL 309
KEE ++R + + + + V +H Q ++ + + + + QE++E +A L
Sbjct: 138 KEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHL 197
Query: 310 KKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVES 369
K+LI++ + E I ++ + +D L A AQ + + L E ++
Sbjct: 198 KRLIDERDEHSETIIELSEERDGLHFLPHAS-SSAQSPCGSPGMKRTESRQHLSVELADA 256
Query: 370 QRMCELMKQQETHLKQQLALYTEKFEEFQ-----------NTLS--KSSEVFTTFKQEME 416
+ ++Q+ +QL ++ E+ + N LS +S+ ++ +
Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316
Query: 417 KMTKKIKKLEKETTMYRSRWESSN--KALLE--------MAEEKTVRDKELEGLQVKIQR 466
+ ++ KLE E + Y+ R KA +E + E KT+ + +LEG + + +
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDK 376
Query: 467 LEKLCRALQTERNDLNKRVQDL 488
L + L+ E L ++ D+
Sbjct: 377 LHE----LEKENLQLKAKLHDM 394
Score = 40.8 bits (94), Expect = 0.003
Identities = 49/272 (18%), Positives = 108/272 (39%), Gaps = 21/272 (7%)
Query: 64 QSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEP 123
Q +L + +E + ++ ED+ S Y +D + E A + + ++++G
Sbjct: 1130 QQSSLENENESVIKEREDLKSLY------DSLIKDHEKLELLHERQASEYESLISKHGTL 1183
Query: 124 EPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLS 183
+ + D + ++Q ++ D + E++K K + L
Sbjct: 1184 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1243
Query: 184 TPEEKL----AALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARS 239
++L + L K+ L +H+N + + + +Q++L E L+ ++ + + +
Sbjct: 1244 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1303
Query: 240 KLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLR 299
KL + C L + +L+EE + + Q + + +EQ+ E
Sbjct: 1304 KLNNQCELLSQLKGNLEEEN-----------RHLLDQIQTLMLQNRTLLEQNMESKDLFH 1352
Query: 300 QENMELAERLKKLIEQYELREEHIDKVFKHKD 331
E + ++L +L Q E EE I +K D
Sbjct: 1353 VEQRQYIDKLNELRRQKEKLEEKIMDQYKFYD 1384
>gi|7705415 hook homolog 1 [Homo sapiens]
Length = 728
Score = 81.3 bits (199), Expect = 2e-15
Identities = 108/471 (22%), Positives = 202/471 (42%), Gaps = 36/471 (7%)
Query: 37 AAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQ---LEDILSTYCVDNNQG 93
++P +A G Q R E Q A+ LR EEL Q L+D ++ +N
Sbjct: 166 SSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMM 225
Query: 94 GPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGD--PNTEEI-RQSDE 150
D G +P + + A+ + E N E +K D + EE+ +Q E
Sbjct: 226 NEKLDQLDGSFDDPNTVVAKKYFHAQL-QLEQLQEENFRLEAAKDDYRVHCEELEKQLIE 284
Query: 151 VGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQM 210
R+ ++ + L EI +L T S KL + + Y + L++ + +KQ+
Sbjct: 285 FQHRNDELTSLAEETRALKDEIDVLRAT----SDKANKLESTVEIYRQKLQDLNDLRKQV 340
Query: 211 KLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEG---------VQ 261
K LQ+ + L E KA AR++LE+ R++Q + L E ++
Sbjct: 341 KTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMK 400
Query: 262 RAREEEE---KRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKL---IEQ 315
R E+ E K KE + TL + ++ + L Q + + + L I
Sbjct: 401 RLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMP 460
Query: 316 YELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCEL 375
E RE I ++K L+ Q ++ ++ +E+ ++ E++H++ + ++ + +R+ EL
Sbjct: 461 VEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIREL 520
Query: 376 MKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSR 435
+Q E L++ L K E SS++ + MEK+T+ ++L+K+ +
Sbjct: 521 QQQIED-LQKSLQEQGSKSEG-----ESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDL 574
Query: 436 WESSNKALLEMAEEKTVRDKELEGLQVKIQR----LEKLCRALQTERNDLN 482
N+ + ++ E + K+ E ++ +R LEK ++T LN
Sbjct: 575 QPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLN 625
Score = 52.4 bits (124), Expect = 1e-06
Identities = 67/302 (22%), Positives = 128/302 (42%), Gaps = 36/302 (11%)
Query: 150 EVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQ 209
+V D + E K+A L E+ L + L +E+L E EE R SQ Q
Sbjct: 377 QVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQ 436
Query: 210 MKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEK 269
L + + + ++L E + + + LQ N+ L+ +Q+ E E+
Sbjct: 437 QDHLNQTDASATKSYENLAAE-----IMPVEYREVFIRLQHENKMLR---LQQEGSENER 488
Query: 270 RKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYE-LREEHIDKVFK 328
+ ++Q Q+EQ + + ++L E ER+++L +Q E L++ ++ K
Sbjct: 489 -----------IEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSK 537
Query: 329 HKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFL------LKEAVESQRMCELMKQQETH 382
+ + KL+ E L E E Q++++ + + + V+ E Q++
Sbjct: 538 SEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDE 597
Query: 383 ----LKQQLALYTEKFEEFQNTLS-----KSSEVFTTFKQEMEKMTKKIKKLEKETTMYR 433
++++ +Y EK TL S+E+ KQ EK ++I+ LE E + +
Sbjct: 598 DMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEK-ERRIEILESECKVAK 656
Query: 434 SR 435
R
Sbjct: 657 FR 658
Score = 50.1 bits (118), Expect = 5e-06
Identities = 49/238 (20%), Positives = 109/238 (45%), Gaps = 11/238 (4%)
Query: 257 EEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQY 316
E+ ++RA EE ++ + ++ +Q+ + + L EN + E+L +L +
Sbjct: 177 EQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSF 236
Query: 317 ELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQ-RMCEL 375
+ + K + H LQ + +LQ+ L+ A++ ++ + L K+ +E Q R EL
Sbjct: 237 DDPNTVVAKKYFHAQLQLE----QLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDEL 292
Query: 376 --MKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYR 433
+ ++ LK ++ + ++ N L + E++ Q++ + K++K L++ MY
Sbjct: 293 TSLAEETRALKDEIDVLRATSDK-ANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYM 351
Query: 434 SRWESSNKALLEMAEEKTVRD---KELEGLQVKIQRLEKLCRALQTERNDLNKRVQDL 488
S + L + +T + ++++ L VK+ K L E L ++ + L
Sbjct: 352 HNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEAL 409
Score = 44.7 bits (104), Expect = 2e-04
Identities = 52/249 (20%), Positives = 111/249 (44%), Gaps = 36/249 (14%)
Query: 175 LMQTLNTLSTPEEKLAA--LCKKYAELLEEHRNSQKQMKL---------LQKKQSQLVQE 223
L QT + + E LAA + +Y E+ ++ K ++L +++ Q QL Q+
Sbjct: 440 LNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQK 499
Query: 224 KDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKE-VTSHF----- 277
+ ++ L++ ++ L ++++ +SL+E+G + E K K+ + +H
Sbjct: 500 HRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTE 559
Query: 278 --------QVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKH 329
Q + D+Q + Q+ ++ ++L + E +K + E+Y++ E V K
Sbjct: 560 VHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKT 619
Query: 330 KDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLAL 389
D + A++ ++ L E E R E +ES+ C++ K ++ K ++
Sbjct: 620 LDPKLNPASAEIMLLRKQLAEKERR---------IEILESE--CKVAKFRDYEEKLIVSA 668
Query: 390 YTEKFEEFQ 398
+ K FQ
Sbjct: 669 WYNKSLAFQ 677
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 78.2 bits (191), Expect = 2e-14
Identities = 91/378 (24%), Positives = 169/378 (44%), Gaps = 55/378 (14%)
Query: 132 EKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKE--ITLLMQT------LNTLS 183
EKE + N E++QS E Q+KK+ + L E I +L +T L+
Sbjct: 951 EKEEQQLQGNINELKQSSE---------QKKKQIEALQGELKIAVLQKTELENKLQQQLT 1001
Query: 184 TPEEKLAALCKKYAELLEEHRNSQKQMKLLQK----KQSQLVQEKDHLRGEHSKAVLARS 239
++LAA +K + L + SQ+ K LQ ++S+L+ + L+ K LA+
Sbjct: 1002 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061
Query: 240 KLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLR 299
L S ++ N+ ++E +A E++ K+ Q +Q ++ + + +L
Sbjct: 1062 DLISNRNQIGNQNKLIQELKTAKATLEQDSAKK-EQQLQERCKALQDIQKEKSLKEKELV 1120
Query: 300 QENMELAE----------RLKKLIEQYELRE-EHIDKVFKHKDLQQQLVDAKL--QQAQE 346
E +LAE + KL E+ + + E I ++ KD +Q L+ KL Q +
Sbjct: 1121 NEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKAD 1180
Query: 347 MLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSE 406
LK A E+ +R + +LK+ V K++E LK++ + EK + + + +
Sbjct: 1181 SLKAAVEQEKRNQQ-ILKDQV---------KKEEEELKKE---FIEKEAKLHSEIKEKEV 1227
Query: 407 VFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQR 466
++ K+T +I L + + W+SS + + E+ +K+ + L+ +I
Sbjct: 1228 GMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSEL-------EKQTDDLRGEIAV 1280
Query: 467 LEKLCRALQTERNDLNKR 484
LE + Q ER L +R
Sbjct: 1281 LEATVQNNQDERRALLER 1298
Score = 73.9 bits (180), Expect = 3e-13
Identities = 89/396 (22%), Positives = 170/396 (42%), Gaps = 27/396 (6%)
Query: 109 DAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGL 168
D E T +++ E E V + + K E I+Q ++ ++ + K+ + L
Sbjct: 762 DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ--KLTKQEEEKQILKQDFETL 819
Query: 169 GKEITLLMQTLNT-LSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHL 227
+E + + LN + T +L + + L+ E + + L K L K
Sbjct: 820 SQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDK---LSKVSDSLKNSKSEF 876
Query: 228 RGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEE---EKRKEVTSHFQVTLNDI 284
E+ K A LE C+EL+ + E ++ +E + EK KE + ++ LN +
Sbjct: 877 EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSM 936
Query: 285 QLQMEQ------HNERNSKLRQENM----ELAERLKKLIE--QYELREEHIDKVFKHKDL 332
Q Q+ Q NE+ + Q N+ + +E+ KK IE Q EL+ + K L
Sbjct: 937 QEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKL 996
Query: 333 QQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHL--KQQLALY 390
QQQL A AQE+ E E+ + ++ + Q + ++ L +Q L
Sbjct: 997 QQQLTQA----AQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 391 TEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEK 450
EK Q L + + ++++ LE+++ + + KAL ++ +EK
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1112
Query: 451 TVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQ 486
++++KEL + K+ +E++ + E LN+ ++
Sbjct: 1113 SLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELK 1148
Score = 63.2 bits (152), Expect = 6e-10
Identities = 105/478 (21%), Positives = 196/478 (41%), Gaps = 92/478 (19%)
Query: 72 SEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPED--AEKSRTYVARNGEPEPTPVV 129
SEEL ++LE G Q + A+P+ + S + + E
Sbjct: 106 SEELKKELEKY---------------QGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTE 150
Query: 130 NGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKL 189
N + K + + + E+ D + +E+ + +++T L + LN +T + L
Sbjct: 151 NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDL 210
Query: 190 -------------AALCKKYAEL--------LEEHRNSQKQMKLLQKKQSQLVQEK---D 225
A L K+ ++ LE R S+K +K QSQ +
Sbjct: 211 KTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATIS 270
Query: 226 HLRGEHSKA-------VLARSKLESLCRELQRHNRSLKEEGVQRARE----EEEKRKEVT 274
LR E +K V KL+S EL + N++L E +++ ++ EE+ +E
Sbjct: 271 QLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESV 330
Query: 275 S--HFQVTLNDIQLQMEQHNERNS----KLRQENMELAER------LKKLIEQYELREEH 322
S + Q TL+ L +Q R S L + ++EL+E+ LK+ + + E + +H
Sbjct: 331 SKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQH 390
Query: 323 IDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETH 382
+ FK LQQQ + K Q ++ E + H + +E++R + +
Sbjct: 391 LKAEFKQ--LQQQR-EEKEQHGLQLQSEINQLHSK--------LLETERQ---LGEAHGR 436
Query: 383 LKQQLALYTEKFEEFQNTLS----KSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWES 438
LK+Q L +EK + + ++ K S + K+++ T+ +L+K ++ +
Sbjct: 437 LKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQAL 496
Query: 439 SNKALLEMAEEKTVRDKELEGL---QVKIQRLEKLCR-------ALQTERNDLNKRVQ 486
++ E + ++ L + KIQ LE L + L+ ER DL ++Q
Sbjct: 497 QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ 554
Score = 60.8 bits (146), Expect = 3e-09
Identities = 63/327 (19%), Positives = 149/327 (45%), Gaps = 22/327 (6%)
Query: 182 LSTPEEKLAALCKKYAELLEEHR----NSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLA 237
L E+++A L K + L E+ + NS + L K + Q +++ + +K A
Sbjct: 448 LMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREA 507
Query: 238 RSKLESLCRELQRHNRSLK--EEGVQRAREE----EEKRKEVTSHFQVTLNDIQLQMEQH 291
++ LE + R++ ++ ++ E +Q+++E E++R+++ + Q + + + Q
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV-LNQL 566
Query: 292 NERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEA 351
E+N L+++ +L E+LK E ++ +E++ + + + ++ + + E
Sbjct: 567 QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626
Query: 352 EERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTF 411
+ K+ + + ++ + EL+ E Q A + QN L +
Sbjct: 627 NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI 686
Query: 412 KQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKT------VRDKELEGLQVKIQ 465
+++++T K++ ++ + S + + L + E+KT ++ E + L+VK
Sbjct: 687 TTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL-EQKTEELEGQIKKLEADSLEVKAS 745
Query: 466 RLEKLCRALQTER---NDLNKRVQDLS 489
+ E+ + LQ +R DL R +LS
Sbjct: 746 K-EQALQDLQQQRQLNTDLELRATELS 771
Score = 60.5 bits (145), Expect = 4e-09
Identities = 70/317 (22%), Positives = 143/317 (45%), Gaps = 22/317 (6%)
Query: 181 TLSTPEEKLAALCKKY-AELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARS 239
+L E+L KK A+ LE + ++ ++ LQ+ Q QL + + E SK +
Sbjct: 720 SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ-QRQLNTDLELRATELSKQLEMEK 778
Query: 240 KLESLCR-ELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNER---- 294
++ S R +LQ+ + +L E Q+ ++EE+++ + F+ + ++Q E+ N R
Sbjct: 779 EIVSSTRLDLQKKSEAL-ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTT 837
Query: 295 ---NSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEA 351
K++ E L L + ++ + + + + Q A + ++ KE
Sbjct: 838 VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL 897
Query: 352 EERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEV---- 407
+ + Q + + LKE E ++ E K+ LK +L E+ + QNTL ++ +
Sbjct: 898 KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL 957
Query: 408 ---FTTFKQEMEKMTKKIKKLEKETTM-YRSRWESSNK---ALLEMAEEKTVRDKELEGL 460
KQ E+ K+I+ L+ E + + E NK L + A+E +++ L
Sbjct: 958 QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVL 1017
Query: 461 QVKIQRLEKLCRALQTE 477
Q ++ ++ + LQ++
Sbjct: 1018 QNNYEKSQETFKQLQSD 1034
Score = 48.5 bits (114), Expect = 2e-05
Identities = 66/309 (21%), Positives = 124/309 (40%), Gaps = 41/309 (13%)
Query: 225 DHLRGEHSKAVLARSKLESLCRELQRHNRSLKE------------EGVQRAREEEEKRKE 272
D G S L R + L +E+Q SLKE E Q +++E K
Sbjct: 69 DSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDG 128
Query: 273 VTSHFQVTLNDIQLQMEQHNERNSKLRQEN-----------MELAERLKKLIEQYELREE 321
+ + L ++ Q+E+ N ++Q E+A+ K E+ LRE
Sbjct: 129 LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 322 HIDKVFK-----------HKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQ 370
KV + +DL+ +L+ + +LK+ + Q D + +E +
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNM---TLERE 245
Query: 371 RMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKL-EKET 429
R E +K + L+ Q A + ++ L+K + + QE++K+ + +L +K
Sbjct: 246 RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQ 305
Query: 430 TMYRS--RWESSNKALLEMAEEKTVRDKELEG-LQVKIQRLEKLCRALQTERNDLNKRVQ 486
T+ + + E L E E++V K ++ L K ++L L L++
Sbjct: 306 TLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHV 365
Query: 487 DLSAGGQGS 495
+LS G+ +
Sbjct: 366 ELSEKGEAT 374
Score = 48.1 bits (113), Expect = 2e-05
Identities = 51/247 (20%), Positives = 110/247 (44%), Gaps = 23/247 (9%)
Query: 163 KKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQK--KQSQL 220
KK + L + L S E++L K AE+ E +K++ L + K +L
Sbjct: 1093 KKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKL 1152
Query: 221 VQEKDHLRGEHSKAVLARSKLE--------SLCRELQRHNRSLKEEGVQRAREEEEKR-- 270
K+ + +K +L + KLE E ++ N+ + ++ V++ EE +K
Sbjct: 1153 ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFI 1212
Query: 271 -KEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKH 329
KE H ++ + ++ M++H E +KL + L E L + ++++ + + ++ K
Sbjct: 1213 EKEAKLHSEI--KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQ 1270
Query: 330 KDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLAL 389
D L+ +L+ + +Q E+ LL+ ++ + E ++ + L+++L
Sbjct: 1271 TD--------DLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDN 1322
Query: 390 YTEKFEE 396
T +E
Sbjct: 1323 TTAAVQE 1329
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 77.8 bits (190), Expect = 2e-14
Identities = 89/357 (24%), Positives = 163/357 (45%), Gaps = 37/357 (10%)
Query: 142 TEEIR--QSDEVGDRDHRRPQ--EKKKA---KGLGKEITLLMQTLNTLSTPEEKLAALCK 194
TEE R Q + R HR+ EKK+A + L +E L Q L+ E KLA +
Sbjct: 1562 TEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLA---Q 1618
Query: 195 KYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRS 254
Y ++ ++ R + +K+ L Q + L E K R KL ++ R
Sbjct: 1619 AYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEK 1678
Query: 255 LKEEGVQRA--------REEEEKRKEVTSHFQVT-----LNDIQLQMEQHNERNSKLRQE 301
L ++G + A + EE ++E +Q L +++ ME+ + + +L QE
Sbjct: 1679 LAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQE 1738
Query: 302 NMELAERLKKLIEQYEL----REEHIDKVFKHKDLQQQLVD--AKLQQAQEMLKEAEERH 355
+L E KKL E+ E RE+ ++ K ++ L+ KL Q +E + E EER
Sbjct: 1739 EGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERL 1798
Query: 356 QREKDFLLKEAVE-SQRMCELMKQQETHLKQQLALYTEK-FEEFQNTLSKSSEVFTTFKQ 413
R+++ L+++ ++ +Q+ + E K ++ LY +K + + L++ E K+
Sbjct: 1799 GRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKE 1858
Query: 414 EMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKL 470
+ +++ +K+ +++ NK +L EEK ++KE I++ EKL
Sbjct: 1859 NLLYNKERLTHSKKQLVQVKNKLGMFNK-ILAQVEEKLTQEKE-----TVIKKKEKL 1909
Score = 61.6 bits (148), Expect = 2e-09
Identities = 77/330 (23%), Positives = 148/330 (44%), Gaps = 57/330 (17%)
Query: 143 EEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEE 202
E++ Q+ E + QE KK K +E + + + + + E++ K E+ E
Sbjct: 1494 EKLHQAGEKLSPEEEMLQEDKKLKW--EEWKQVWENMLSSKSKEQQY----KDEEEVTLE 1547
Query: 203 HRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQR 262
S++ ++K+ Q+ +E+ H++ EH A + R + + + Q R L +E +
Sbjct: 1548 EEVSREG----EEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE-RKLAQEEEKL 1602
Query: 263 AREE----EEKRKEVTSHFQVTLNDIQLQMEQHN---------ERNSKLRQENMELAERL 309
A+EE +E+RK ++ ++T +D ++ + +R KL QE +LA++
Sbjct: 1603 AQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKR 1662
Query: 310 KKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEML-KEAEERHQREKDFLLKEAVE 368
KKL +++E +K+ K KL + + +L ++ EE QRE++
Sbjct: 1663 KKLAKKWEKVAREEEKLAKK--------GGKLAEVKNILAQKVEELPQREQN-------- 1706
Query: 369 SQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKL--E 426
+ QE L Q+L EE + + + S QE K+ ++ KKL E
Sbjct: 1707 -------LDWQEKELAQEL-------EELEWDMEELSWKEEELNQEEGKLVEEKKKLAEE 1752
Query: 427 KETTMYRSRWESSNKALLEMAEEKTVRDKE 456
+E ++ S + L EE +++KE
Sbjct: 1753 EEALAWQREKLSEEETKLAQEEELLIQEKE 1782
Score = 52.4 bits (124), Expect = 1e-06
Identities = 51/239 (21%), Positives = 103/239 (43%), Gaps = 27/239 (11%)
Query: 144 EIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELL--E 201
+I++ D R EKK A+ K + + +N E+ + L +K++E++ +
Sbjct: 2119 DIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDD 2178
Query: 202 EHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARS------------KLESLCRELQ 249
E ++ +++ + + + K+ RG+ K + ++ESL EL+
Sbjct: 2179 EEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELE 2238
Query: 250 RHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERL 309
+ EE +R EEE + +EV + E+ E + +Q E E+
Sbjct: 2239 KQESLSSEEEEEREEEEEREEEEVREE----------EEERKEEEEGEEKQVEKEEEEKK 2288
Query: 310 KKLIEQYELREEHIDKVFKHKD---LQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKE 365
KK E+ + + ++VF+ K+ +++ ++ +E EE REK+ L KE
Sbjct: 2289 KKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKE 2347
Score = 51.6 bits (122), Expect = 2e-06
Identities = 62/291 (21%), Positives = 125/291 (42%), Gaps = 29/291 (9%)
Query: 175 LMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQM-----------KLLQKKQSQLVQE 223
L Q L+ +EKLA + E +S+KQ+ K+L + + +L QE
Sbjct: 1839 LAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQE 1898
Query: 224 KDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEE--EKRKEVTSHFQVTL 281
K+ + + K KL + L + L +E ++ A E+ + +K + +
Sbjct: 1899 KETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAK 1958
Query: 282 NDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKL 341
+ L +E +L +E M L E K+ + + E E + K ++Q+L + KL
Sbjct: 1959 EEKALNLEM-----KRLAEEKMRLVEG-KETLSKGETPETSRQR--KMTQVEQELFERKL 2010
Query: 342 QQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTL 401
+++L + E+ + K +E R + Q + ++LA + K + + +L
Sbjct: 2011 SLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQ----RKLAKASRKLIKKRESL 2066
Query: 402 SKSSEVFTTFKQEMEKMTKKIKKLEKE----TTMYRSRWESSNKALLEMAE 448
SK + ++K+T+ +KL +E T M R+ + + +E ++
Sbjct: 2067 SKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSK 2117
Score = 51.2 bits (121), Expect = 2e-06
Identities = 84/424 (19%), Positives = 174/424 (41%), Gaps = 60/424 (14%)
Query: 111 EKSRTYVARNGEPEPTPVVNGEKEPSKGD-PNTEEIRQSDEVGDRDHRRPQEKKKAKGLG 169
EK+ + E +V G++ SKG+ P T R+ +V +++ + L
Sbjct: 1960 EKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQV--------EQELFERKLS 2011
Query: 170 KEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRG 229
E +L+ L+ E ++A K E R + + L K +L+++++ L
Sbjct: 2012 LEEKILLHEDRILAMEESEIA---KGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSK 2068
Query: 230 EHSKAVLARSKLESLCRELQRHNRSLKEEGVQ-----RAREEEEKRKEVT-SHFQVTLND 283
E +K +K+ ++L R R L +E ++ RA +E+R + S + D
Sbjct: 2069 EPAKL----NKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWD 2124
Query: 284 IQLQMEQHNERNSKLRQENMELAERLKKLIEQYE-LREEHIDKVFKHKD----------L 332
+ + + KL ++ +LA +++++I + E + EE KH + +
Sbjct: 2125 FSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGI 2184
Query: 333 QQQLVDAKLQQAQEMLKEAEERHQREKDFL--LKEAVESQRMCELMKQQETHLKQQLALY 390
+++ V L++ KEA+ + ++ F + E + E M+ L++Q +L
Sbjct: 2185 EEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLS 2244
Query: 391 TEKFEEFQNTLSKSSEVFTTFKQEM---------------EKMTKKIKKLEKETTMYRSR 435
+E+ EE + + E ++E E+ KK K+ +KE +
Sbjct: 2245 SEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEE 2304
Query: 436 WESSNKALLEMAEEKTVRDKELE----------GLQVKIQRLEKLCRALQTERNDLNKRV 485
+ ++ E +++ D+E E + +I + EK + + R L R
Sbjct: 2305 VFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRE 2364
Query: 486 QDLS 489
+ LS
Sbjct: 2365 RVLS 2368
Score = 49.7 bits (117), Expect = 7e-06
Identities = 92/421 (21%), Positives = 166/421 (39%), Gaps = 97/421 (23%)
Query: 142 TEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLE 201
T+E+ + EV R+ + Q+K + LG E T + + KK +++
Sbjct: 1333 TQEVIRHKEVMPREEEQAQKKARDM-LGLEETQV----------------ILKKGKKVIF 1375
Query: 202 EHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQ 261
+ K + KK+ + +K +G KAV K+ + RE+ + R + EE +
Sbjct: 1376 LEPGNVTMGKEISKKEEKKTFQKSPKQGR--KAVQKERKVGKIKREMTKEERDMSEEVEE 1433
Query: 262 RAREEEEKRK--------EVTSHFQVTLNDIQLQMEQHNER-----------NSKLRQEN 302
A EE+ K E T +Q + H E +L QE
Sbjct: 1434 MATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEE 1493
Query: 303 MELAERLKKLIEQYELREEHIDKVFKHKDLQQ---QLVDAKLQQAQ-----------EML 348
+L + +KL + E+ +E DK K ++ +Q ++ +K ++ Q E+
Sbjct: 1494 EKLHQAGEKLSPEEEMLQE--DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVS 1551
Query: 349 KEAEER--------------------HQREKDFLLKEAVESQRMC---ELMKQQETHLKQ 385
+E EE+ H++ K A E +++ E + Q+E L Q
Sbjct: 1552 REGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQ 1611
Query: 386 -----------------QLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKE 428
++A KF + + TL++ E QE EK+ +K KKL K+
Sbjct: 1612 EERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGE---KLSQEAEKLAQKRKKLAKK 1668
Query: 429 TTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDL 488
E K ++AE K + +++E L + Q L+ + L E +L +++L
Sbjct: 1669 WEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEEL 1728
Query: 489 S 489
S
Sbjct: 1729 S 1729
Score = 47.8 bits (112), Expect = 3e-05
Identities = 60/291 (20%), Positives = 124/291 (42%), Gaps = 9/291 (3%)
Query: 199 LLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEE 258
L EE + Q KL + +++QE L+ E K V + L S +E Q +
Sbjct: 1490 LQEEEKLHQAGEKL--SPEEEMLQEDKKLKWEEWKQVW-ENMLSSKSKEQQYKDEEEVTL 1546
Query: 259 GVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYEL 318
+ +RE EEK ++VT + IQ + + + R E E K E+ +L
Sbjct: 1547 EEEVSREGEEKEQQVTEEQR----HIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKL 1602
Query: 319 REEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQ 378
+E + + L Q V K+ Q + +AE + ++++ L + + + E + Q
Sbjct: 1603 AQEERQLAQEERKLAQAYV--KITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQ 1660
Query: 379 QETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWES 438
+ L ++ + E+ K +EV Q++E++ ++ + L+ + E
Sbjct: 1661 KRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEE 1720
Query: 439 SNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLS 489
+ E++ ++ ++E L + ++L + AL +R L++ L+
Sbjct: 1721 LEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLA 1771
Score = 31.6 bits (70), Expect = 2.0
Identities = 29/149 (19%), Positives = 62/149 (41%), Gaps = 15/149 (10%)
Query: 72 SEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNG 131
SEE+ L+++ + + + E+ + E E + E+ R GE +
Sbjct: 2227 SEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKE-EEEGEEKQVEKEEE 2285
Query: 132 EKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAA 191
EK+ K + EE+++ +EV + +EI +T + EE+ +
Sbjct: 2286 EKKKKKKEKKKEEVQEKEEVFEEK--------------EEIMSEEETESLSDEEEEEESC 2331
Query: 192 LCKKYAELLEEHRNSQKQMKLLQKKQSQL 220
++ + +E +KQ KL ++++ L
Sbjct: 2332 SLEEEVDREKEILKKEKQFKLQEQRRKSL 2360
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 77.8 bits (190), Expect = 2e-14
Identities = 82/349 (23%), Positives = 166/349 (47%), Gaps = 39/349 (11%)
Query: 161 EKKKAKGLGKEITLLMQTL------NTLSTPE--EKLAALCKKYAELLEEHRNSQKQMKL 212
+KKKA +E+T L NT++ E EK A L +K + E Q +K
Sbjct: 175 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 234
Query: 213 LQKK---------QSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRA 263
L++K Q QL E DHL G+ ++V A+ + + EL +EE + R
Sbjct: 235 LKRKLERAKLLLPQQQLQAEADHL-GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ 293
Query: 264 REEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHI 323
E+ ++R+E IQ Q E+ E+ K+R++ + E+ +K+ Q E+ E
Sbjct: 294 EEKIQEREE----------KIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 343
Query: 324 DKV--FKHKDLQQQLV--DAKLQQAQEMLKEAEERHQRE-KDFLLKEAVESQRMCELMKQ 378
+K+ + K +Q+ + + +Q +E ++E E+R ++E K + +E + Q E +++
Sbjct: 344 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE--EKIRE 401
Query: 379 QETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWES 438
QE +++Q EK E + + + E +++M + +KI++ EK+ +
Sbjct: 402 QEEMMQEQ----EEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 457
Query: 439 SNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQD 487
+ + E E+ ++ ++ + K+Q E+ R + + + K++++
Sbjct: 458 QEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIRE 506
Score = 74.3 bits (181), Expect = 3e-13
Identities = 69/372 (18%), Positives = 176/372 (47%), Gaps = 40/372 (10%)
Query: 132 EKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAA 191
E E S+ N +E+++ E + Q + +A LGKE+ + L E
Sbjct: 222 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 281
Query: 192 LCKKYAELL-EEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKL---ESLCRE 247
L ++ E + + Q++ + +Q+++ ++ ++++ +R + K+ E + E
Sbjct: 282 LNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 341
Query: 248 LQRHNRSLKEE--GVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMEL 305
+ R L+E+ ++ RE+EEKR+E + + E+ E+ +K+ ++ ++
Sbjct: 342 KEEKIRELEEKMHEQEKIREQEEKRQE---------EEKIREQEKRQEQEAKMWRQEEKI 392
Query: 306 AERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKE 365
E+ +K+ EQ E+ +E +K+ + ++ K+ + +E ++E EE+ +R+++ + ++
Sbjct: 393 REQEEKIREQEEMMQEQEEKMGEQEE--------KMWEQEEEMQEQEEKMRRQEEKIREQ 444
Query: 366 AVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKM------- 418
+ +++QE +++Q + E+ E+ K E +++ EKM
Sbjct: 445 EKK-------IREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKI 497
Query: 419 ---TKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQ 475
KKI++ E++ + + + E E+ ++++++ + K++R E+ R +
Sbjct: 498 REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQE 557
Query: 476 TERNDLNKRVQD 487
+++Q+
Sbjct: 558 VRLRQQEEKMQE 569
Score = 49.3 bits (116), Expect = 9e-06
Identities = 37/188 (19%), Positives = 92/188 (48%), Gaps = 8/188 (4%)
Query: 143 EEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEE 202
E+IR+ +E QE+++ +G++ + + + EEK+ ++ E + E
Sbjct: 390 EKIREQEEKIREQEEMMQEQEEK--MGEQEEKMWEQEEEMQEQEEKM----RRQEEKIRE 443
Query: 203 HRNSQKQMKLLQKKQSQLVQEKDHLRGEHS-KAVLARSKLESLCRELQRHNRSLKEEGVQ 261
++ + ++Q +++QE++ GE K +K++ +++R ++E+ +
Sbjct: 444 QEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQE-K 502
Query: 262 RAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREE 321
+ RE+EEK +E Q + Q E+ E+ K++++ ++ + +K+ EQ +
Sbjct: 503 KIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQ 562
Query: 322 HIDKVFKH 329
+K+ +H
Sbjct: 563 QEEKMQEH 570
Score = 32.7 bits (73), Expect = 0.88
Identities = 33/146 (22%), Positives = 70/146 (47%), Gaps = 13/146 (8%)
Query: 350 EAEERHQREKDFLLKEAVESQ-RMCELMKQQETHLKQQLALYTEKFE------EFQNTLS 402
E E++ + L+ +E+Q + ++ Q+T L Q+ALY + E ++ +S
Sbjct: 96 EDEQKASHQHQEALRRELEAQVQTIRILTCQKTEL--QMALYYSQHAVKQLEGEARDLIS 153
Query: 403 KSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQV 462
+ + + F E+E+ + +K+ Y AL T+ D+EL+
Sbjct: 154 RLHDSWK-FAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 212
Query: 463 KIQRLEKLCRALQTERNDLNKRVQDL 488
K+Q EKL + +++E++++ V++L
Sbjct: 213 KLQ--EKL-QLVESEKSEIQLNVKEL 235
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 77.0 bits (188), Expect = 4e-14
Identities = 61/261 (23%), Positives = 131/261 (50%), Gaps = 28/261 (10%)
Query: 198 ELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRG--EHSKAVLARSKLESLCRELQRHNRSL 255
EL +++ Q+++ L + ++S++ L+ E +K +L + + +L E+ R L
Sbjct: 222 ELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEEL 281
Query: 256 KEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQ 315
+E+ ++ R++EEK + ++ Q E+ + +LR++ EL E+ K+L EQ
Sbjct: 282 REQ-EKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQ 340
Query: 316 YELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCEL 375
ELRE+ + Q Q + K+ + +E ++E EE+ R+++ L ++ + + +
Sbjct: 341 KELREQ---------EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 391
Query: 376 MKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSR 435
M+ QE + +Q EK E +E EKM ++++K+ +E M
Sbjct: 392 MRDQEERMWEQDERLREKEERM---------------REQEKMWEQVEKMREEKKMQEQE 436
Query: 436 WESSNKALLEMAEEKTVRDKE 456
++ ++ +M EE+ +R++E
Sbjct: 437 KKTRDQE-EKMQEEERIRERE 456
Score = 71.6 bits (174), Expect = 2e-12
Identities = 77/400 (19%), Positives = 183/400 (45%), Gaps = 41/400 (10%)
Query: 97 EDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDH 156
E + + + ++ E+ R + E E T ++ K E + + +E +
Sbjct: 436 EKKTRDQEEKMQEEERIREREKKMREEEETM----REQEEKMQKQEENMWEQEEKEWQQQ 491
Query: 157 RRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKK 216
R P++K+K K + + + EEK+ + E+ + + +Q K+ +++
Sbjct: 492 RLPEQKEKLWEQEK----MQEQEEKIWEQEEKI----RDQEEMWGQEKKMWRQEKM-REQ 542
Query: 217 QSQLVQEKDHLRGEHSKAVLARSKLESLCRELQR----HNRSLKEEGVQRARE------- 265
+ Q+ ++++ +R + K ++E +E ++ ++EE R RE
Sbjct: 543 EDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 602
Query: 266 -----EEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELRE 320
+EEK +E Q + Q E+ E+ K+ ++ ++ E+ +K+ EQ L E
Sbjct: 603 EMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662
Query: 321 EHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKE-AVESQRMCELMKQQ 379
+ +K+++H+ +Q+Q K+Q+ +E + E E+ ++ ++ K E R E M+++
Sbjct: 663 QK-EKLWEHEKMQEQ---EKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRER 718
Query: 380 ETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSR---W 436
E ++++ + E+ E+ Q K E ++ EKM ++ +K+ ++ + + W
Sbjct: 719 EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 778
Query: 437 E----SSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCR 472
E + + E E+ +++++ G + K++ E+ R
Sbjct: 779 EHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
Score = 71.2 bits (173), Expect = 2e-12
Identities = 82/369 (22%), Positives = 179/369 (48%), Gaps = 50/369 (13%)
Query: 146 RQSDEVGDRDHR-RPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHR 204
RQ +E+ +++ + R QE+K + ++ L + + EEK+ K+ E +E R
Sbjct: 276 RQEEELREQEKKIRKQEEK----MWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELR 331
Query: 205 NSQKQMK----------LLQKKQSQLVQEKDHLRGEHSKAVLARSKL---ESLCRELQRH 251
+K+++ +Q+++ ++ ++++ +R + K +L E RE ++
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 391
Query: 252 NRSLKE---EGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAER 308
R +E E +R RE+EE+ +E ++ + + Q E+ ++ ++E M+ ER
Sbjct: 392 MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEER 451
Query: 309 L----KKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEER-HQREKDFLL 363
+ KK+ E+ E E +K+ K ++ + + + QQ + L E +E+ ++EK
Sbjct: 452 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ--QRLPEQKEKLWEQEKMQEQ 509
Query: 364 KEAVESQRMCELMKQQETHLKQQLALY-TEKFEEFQNTLSKSSEVFTTFKQEM----EKM 418
+E + Q E ++ QE Q+ ++ EK E ++ + + E +Q+M E+M
Sbjct: 510 EEKIWEQE--EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 567
Query: 419 TKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTER 478
KK ++ EK+T W+ K M EE+ +R++E K++ E++ R + +
Sbjct: 568 EKKTQEQEKKT------WDQEEK----MREEERMRERE-----KKMREEEEMMREQEEKM 612
Query: 479 NDLNKRVQD 487
+ +++Q+
Sbjct: 613 QEQEEKMQE 621
Score = 70.9 bits (172), Expect = 3e-12
Identities = 73/326 (22%), Positives = 149/326 (45%), Gaps = 53/326 (16%)
Query: 163 KKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQ 222
K+ K + L+ + T + EE + ++ EL E+ + +KQ + + +++ +L +
Sbjct: 249 KELKRKLERAKFLLPQVQTNTLQEE----MWRQEEELREQEKKIRKQEEKMWRQEERLRE 304
Query: 223 EKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREE------------EEKR 270
++ +R + K +L +EL+ + L+E+ R +EE EEK
Sbjct: 305 QEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKM 364
Query: 271 KEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYE-LRE-----EHID 324
+E + Q +Q E+ K+R + + E+ ++L E+ E +RE E ++
Sbjct: 365 REQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVE 424
Query: 325 KVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLK 384
K+ + K +Q+Q + K + +E ++E E +REK ++E E+ R +Q+E K
Sbjct: 425 KMREEKKMQEQ--EKKTRDQEEKMQEEERIREREKK--MREEEETMR-----EQEEKMQK 475
Query: 385 QQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALL 444
Q+ ++ ++ +E+Q +Q + + +K+ + EK WE
Sbjct: 476 QEENMWEQEEKEWQ-------------QQRLPEQKEKLWEQEKMQEQEEKIWEQ------ 516
Query: 445 EMAEEKTVRDKELEGLQVKIQRLEKL 470
EEK +E+ G + K+ R EK+
Sbjct: 517 ---EEKIRDQEEMWGQEKKMWRQEKM 539
Score = 63.2 bits (152), Expect = 6e-10
Identities = 67/343 (19%), Positives = 167/343 (48%), Gaps = 25/343 (7%)
Query: 143 EEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEE 202
+E+R+ E+ +++ + ++++K + ++ + + + EE+L K+ E ++
Sbjct: 335 KELREQKELREQEEQMQEQEEK---MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 391
Query: 203 HRNSQKQM-----KLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKE 257
R+ +++M +L +K++ QEK E + + K++ ++ + ++E
Sbjct: 392 MRDQEERMWEQDERLREKEERMREQEK---MWEQVEKMREEKKMQEQEKKTRDQEEKMQE 448
Query: 258 EGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYE 317
E +R RE E+K +E + +Q Q E E+ K Q+ L E+ +KL EQ +
Sbjct: 449 E--ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ-RLPEQKEKLWEQEK 505
Query: 318 LREEHIDKVF----KHKDLQQQLVDAKLQQAQEMLKEAE----ERHQREKDFLLKEAVES 369
++E+ +K++ K +D ++ K QE ++E E E+ ++ +D K +
Sbjct: 506 MQEQE-EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQE 564
Query: 370 QRMCELMKQQE--THLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEK 427
+RM + ++QE T +++ E+ E + + + E+ +++M++ +K+++ E+
Sbjct: 565 ERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 624
Query: 428 ETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKL 470
+ + + + + E E+ +++++ Q ++ EKL
Sbjct: 625 KMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKL 667
Score = 42.0 bits (97), Expect = 0.001
Identities = 45/247 (18%), Positives = 114/247 (46%), Gaps = 24/247 (9%)
Query: 143 EEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEE 202
E++ + +E R P++K+K K MQ + EEK+ K + E+
Sbjct: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEK-----MQEQEKMQEQEEKIWEQEKMEKKTQEQ 699
Query: 203 HRNSQKQMKL-----LQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSL-- 255
+ + Q K+ +++++ ++ +E++ +R + K K++ E+ +
Sbjct: 700 EKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWE 759
Query: 256 KEEGVQRAREEEEKRKEVTSHFQVTLND-IQLQMEQHNERNSKLRQENMELAERLKKLIE 314
+EE + + E+++++ H ++ + I Q E+ ++ K+R + ++ + +K+
Sbjct: 760 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRG 819
Query: 315 QYELREEHIDKVFKHKDL----------QQQLVDAKLQQAQEMLKEAEERHQREKDFLLK 364
Q E +K++ ++ Q++ ++ K+Q +E ++E EE+ R ++ ++
Sbjct: 820 QEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEK-MRGQEEKMR 878
Query: 365 EAVESQR 371
E E R
Sbjct: 879 EQEEKMR 885
Score = 40.4 bits (93), Expect = 0.004
Identities = 39/177 (22%), Positives = 86/177 (48%), Gaps = 12/177 (6%)
Query: 283 DIQLQMEQHNERNSKLRQENMELAERLKKL-IEQYE--LREEHIDKVFKHKDLQQQLVDA 339
++Q + + R+ K + EL + L +E Y + E + K K+ +LQ++L A
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKK--KNAELQEKLPLA 237
Query: 340 KLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQN 399
+ ++++ L E + + E+ L V++ + E M +QE L++Q ++ E+
Sbjct: 238 ESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR 297
Query: 400 TLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKE 456
+ E +++ EKM ++ K+L ++ R + + E+ E+K +R++E
Sbjct: 298 QEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEK-------ELREQKELREQE 347
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 76.3 bits (186), Expect = 7e-14
Identities = 86/413 (20%), Positives = 183/413 (44%), Gaps = 39/413 (9%)
Query: 97 EDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDP--------NTEEI-RQ 147
ED + EP + + E+ + + + + GE++ K + EE+ RQ
Sbjct: 117 EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQ 176
Query: 148 SDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQ 207
E +R+ RR +E++ G E T P+E+ + ELLE R +
Sbjct: 177 RQEWQEREERRAEEEQLQSCKGHE---------TEEFPDEEQL----RRRELLELRRKGR 223
Query: 208 KQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEE 267
++ + ++++ V +++ + + + R + E L E + R L+EE Q + E
Sbjct: 224 EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER 283
Query: 268 EK----RKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHI 323
++ R+E Q + QL+ +Q ER R++ E E+ ++ +Q E RE+ +
Sbjct: 284 QELRRERQEEEQQQQRLRREQQLRRKQEEER----REQQEERREQQERREQQEERREQQL 339
Query: 324 DKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQRE----KDFLLKEAVESQRMCELMKQQ 379
+ + + QQ + + ++ ++ L+ +E +RE ++ L+ + +R +L ++Q
Sbjct: 340 RREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQ 399
Query: 380 ETHLKQQL-----ALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRS 434
+ +QQL ++ Q + E K E E+ +++K+ ++E +
Sbjct: 400 QLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459
Query: 435 RWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQD 487
R E + + E +++ RD+E E + ++ E+ R Q R +R Q+
Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512
Score = 71.6 bits (174), Expect = 2e-12
Identities = 93/394 (23%), Positives = 185/394 (46%), Gaps = 46/394 (11%)
Query: 143 EEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEE 202
E Q +E ++ RR QE+++ + L +E + EE+ + + L
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385
Query: 203 HRNSQKQMKLLQKKQ---SQLVQEKDHLRGEHS---KAVLARSKLESLCRELQRHNRSLK 256
+ +++ +L +++Q Q ++ + LR E + L R + E R Q+H + +
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE--RHEQKHEQERR 443
Query: 257 EEGVQRAREEEE---KRKEVTSHFQVTLNDIQLQMEQHNERNSKL----RQENMELAERL 309
E+ ++R +EE KR+E T + QL+ +Q ER + +E E ER
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503
Query: 310 KKLI--EQYELREEHIDKVFKHKDLQQQL-VDAKLQQAQE------MLKEAEERHQREKD 360
++ + EQ E RE+ + + + + LQQ+L + +L++ QE + +E E+R ++E+
Sbjct: 504 EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563
Query: 361 FLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTK 420
+ + +R +L+K++E +Q+L E+ E + L + E +QE E+ +
Sbjct: 564 EQRLKREQEERRDQLLKREEERRQQRLK--REQEERLEQRLKR--EEVERLEQE-ERREQ 618
Query: 421 KIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKEL--EGLQVKIQRL------EKLCR 472
++K+ E E E + LL+ E++ R ++L E + + QRL E+L +
Sbjct: 619 RLKREEPE--------EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ 670
Query: 473 ALQTERNDLNKRVQDLSAGGQGSLTDSGPERRPE 506
L+ E + +R Q+L+ Q + R P+
Sbjct: 671 RLKREHEE-ERREQELAEEEQEQARERIKSRIPK 703
Score = 70.1 bits (170), Expect = 5e-12
Identities = 71/353 (20%), Positives = 163/353 (46%), Gaps = 44/353 (12%)
Query: 132 EKEPSKGDPNTEEIRQSDEVG-DRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLA 190
E+E + + E+ R+ + +++ RR K++ + E Q L E +
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR-- 485
Query: 191 ALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQR 250
+++ +L EE R Q++ +++ QL +E++ R + K +L+ R Q+
Sbjct: 486 ---ERWLKLEEEERREQQE-----RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ 537
Query: 251 HNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENME------ 304
R +E Q + EEEKR E Q + + + +Q +R + RQ+ ++
Sbjct: 538 LRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597
Query: 305 LAERLKK----LIEQYELREEHIDKVFKHKDLQQQLVDAKLQQ---AQEMLKEAEERHQR 357
L +RLK+ +EQ E RE+ + + ++ +QQL+ ++ Q+ Q++ +E +ER ++
Sbjct: 598 LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Query: 358 EKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTL---------------- 401
LK E +R+ + +K++ +++ L E+ E+ + +
Sbjct: 658 R----LKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713
Query: 402 SKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRD 454
++ S+V++ +++ + ++ ++ ++ +W+ +A + EE+ RD
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766
Score = 69.3 bits (168), Expect = 8e-12
Identities = 74/315 (23%), Positives = 151/315 (47%), Gaps = 21/315 (6%)
Query: 186 EEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGE---HSKAVLARSKLE 242
+E+ A C LL++ R + Q + + + QL +E R + + LA + +
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRF-EPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 243 SLCRE-LQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQE 301
S +E L++ +R ++E + R R+E ++R+E + + + + E+ + R+E
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 302 NMELAERLKKLIEQYELREEHIDKVFKHKDLQQ-QLVDAKLQQAQEMLKEAEERHQREKD 360
+EL R K E+ + R E D+VF+ ++ ++ + + L++ +E L+E E + QRE
Sbjct: 215 LLEL--RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 361 F-------LLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQ 413
L ++ + +R E +QQ +QQL E EE + + E +Q
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE--EERREQQEERREQQERREQ 330
Query: 414 EMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRA 473
+ E+ +++++ ++E + R E E E++ R++E E + +++R ++L R
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEE----ERREQQLRREQEEERREQQLRREQQLRRE 386
Query: 474 LQTERNDLNKRVQDL 488
Q R +R Q L
Sbjct: 387 QQLRREQQLRREQQL 401
Score = 67.4 bits (163), Expect = 3e-11
Identities = 82/354 (23%), Positives = 158/354 (44%), Gaps = 42/354 (11%)
Query: 143 EEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEE 202
E++R+ ++ + Q +++ K +E + L EE+L ++ E
Sbjct: 897 EQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER 956
Query: 203 HRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQR 262
R +K KL Q+K+ QL+ E+ R + + R L++E Q
Sbjct: 957 ERQYRKDKKL-QQKEEQLLGEEPEKRRRQER------------EKKYREEEELQQEEEQL 1003
Query: 263 AREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEH 322
REE EKR+ Q D +++Q E+ + +E L ER ++ E+ EL++E
Sbjct: 1004 LREEREKRRRQEWERQYRKKD---ELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060
Query: 323 IDKVFKHKDL-------QQQLVDAKLQQAQEML--KEAEERHQREKDFLLKEAVESQRMC 373
+ + ++ +Q + +LQQ +E L +E E+R ++E++ +E E Q+
Sbjct: 1061 EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE 1120
Query: 374 E--LMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTM 431
E L +++E +Q+L + EE Q E ++E EK ++ ++LE++
Sbjct: 1121 EQLLREEREKRRRQELERQYREEEEVQ------QEEEQLLREEPEK--RRRQELERQ--- 1169
Query: 432 YRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRAL----QTERNDL 481
YR E + + EE+ R +E E + + L++ R + +R+DL
Sbjct: 1170 YREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDL 1223
Score = 67.0 bits (162), Expect = 4e-11
Identities = 84/389 (21%), Positives = 170/389 (43%), Gaps = 24/389 (6%)
Query: 111 EKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGK 170
E R+ + EPE V K KG N E+ RQ ++ RD + Q+ + G +
Sbjct: 1217 EDQRSDLKWQWEPEKENAVRDNKVYCKGREN-EQFRQLEDSQLRDRQSQQDLQHLLGEQQ 1275
Query: 171 EITLLMQTLNTLST----PEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQL------ 220
E + PEE+ ++ E R SQ++ +LL++++ +
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLER-EEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334
Query: 221 ---VQEKDHLRGEHSKAVLARSKLESLCRELQ-RHNRSLKE--EGVQRAREEEEKRKEVT 274
+E++ L E + L R + + RE + RH ++ E QR R +E +RK +
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLK 1394
Query: 275 SHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYEL--REEHIDKVFKHKDL 332
Q+ + + Q+ Q +R + ++ + ER +K E+ + R+E K + +
Sbjct: 1395 EEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454
Query: 333 QQQLVDAKLQQAQEMLKEAEER--HQREKD-FLLKEAVESQRMCELMKQQETHLKQQLAL 389
+Q K ++ +++L+E EE+ H++E+D L+E + +R K +E L+ Q
Sbjct: 1455 LRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE 1514
Query: 390 YTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEE 449
EE Q + F +Q++ + + ++ + +R E + E
Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE-EQLRQEREEQQLS 1573
Query: 450 KTVRDKELEGLQVKIQRLEKLCRALQTER 478
+ RD++ + K++R E+ + ++ E+
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQ 1602
Score = 63.5 bits (153), Expect = 5e-10
Identities = 79/382 (20%), Positives = 168/382 (43%), Gaps = 51/382 (13%)
Query: 132 EKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAA 191
E++ + + + + + ++ HR+ +E+++ +E L Q + EE+
Sbjct: 1436 EQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLR 1495
Query: 192 LC-----------------KKYAELLEEHRNSQKQMKLLQKKQSQLVQEK------DHLR 228
+K+ E ++ Q+Q K LQ++Q QE+ D R
Sbjct: 1496 RQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555
Query: 229 GEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQM 288
+ L + + E +R + EE Q+ R +E++RK + Q+ + Q Q+
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDRKFRLEE--QKVRRQEQERKFMEDEQQLRRQEGQQQL 1613
Query: 289 EQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEML 348
Q ER+ K R++ L ER E+ +L + D+ F ++ Q + Q+ ++ L
Sbjct: 1614 RQ--ERDRKFREDEQLLQER-----EEQQLHRQERDRKFLEEEPQ-----LRRQEREQQL 1661
Query: 349 KEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVF 408
+ +R RE++ LL+E E Q L +Q+ ++ + E + L + ++
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQ----LRRQERDRKFREEEQQLRRQERERKFLQEEQQL- 1716
Query: 409 TTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLE 468
+QE+E+ ++ ++L +ET + R + + +LE + + R+++ Q++ Q +
Sbjct: 1717 --RRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ----QLRRQERD 1770
Query: 469 KLCR---ALQTERNDLNKRVQD 487
+ R L+ ER + R Q+
Sbjct: 1771 RKFREEEQLRQEREEQQLRSQE 1792
Score = 62.4 bits (150), Expect = 1e-09
Identities = 79/355 (22%), Positives = 159/355 (44%), Gaps = 29/355 (8%)
Query: 132 EKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAA 191
+++ K E++ +E +R HR+ QE+++ + + T Q ++L+A
Sbjct: 733 QEQEEKRRRRESELQWQEE--ERAHRQQQEEEQRR----DFTWQWQAEEKSERGRQRLSA 786
Query: 192 ---LCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCREL 248
L ++ L Q++ + L +++ + +++ R E K + + E L R
Sbjct: 787 RPPLREQRERQLRAEERQQREQRFLPEEEEK--EQRRRQRREREKELQFLEEEEQLQRRE 844
Query: 249 QRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAER 308
+ +E+G+Q E++E+R+ S Q + Q+E+ +R L E+
Sbjct: 845 RAQQLQEEEDGLQ---EDQERRR---SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQ 898
Query: 309 LKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVE 368
L+K EQ L+EE ++LQ++ + + +Q QE EE+ Q+E++ LL+E E
Sbjct: 899 LRK--EQQLLQEEE-------EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE 949
Query: 369 SQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKE 428
+R E +Q K Q EE + + E ++E+++ +++ + E+E
Sbjct: 950 KRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE 1009
Query: 429 TTMYRSRWESS--NKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDL 481
R WE K L+ EE+ +R++ + + +R + LQ E L
Sbjct: 1010 KRR-RQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQL 1063
Score = 62.0 bits (149), Expect = 1e-09
Identities = 83/377 (22%), Positives = 162/377 (42%), Gaps = 51/377 (13%)
Query: 127 PVVNGEKEPSKGDPNTEEIRQSDEV---GDRDHRRPQEKKKAKGLGKEITLLMQTLNTLS 183
P +E K EE++Q +E +R+ RR QE ++ + + L
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ----------YRKKDELQ 1027
Query: 184 TPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLES 243
EE+L ++ L E R +++ +L Q+++ L +E++ R R +LE
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRR---------RQELER 1078
Query: 244 LCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHN---ERNSKLRQ 300
R+ L++E Q REE EKR+ Q + +LQ E+ E K R+
Sbjct: 1079 QYRK----EEELQQEEEQLLREEPEKRRRQERERQCREEE-ELQQEEEQLLREEREKRRR 1133
Query: 301 ENMELAERLKKLIEQYE---LREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQR 357
+ +E R ++ ++Q E LREE + + + Q + + Q+ +++L+E +E+ ++
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193
Query: 358 EKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTL--------SKSSEVFT 409
E++ +E E QR + KQ+ Q+ L + E +N + + +E F
Sbjct: 1194 ERERQYREEEELQR--QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFR 1251
Query: 410 TFKQEMEKMTKKIKKL--------EKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQ 461
+ + + + L E++ R RW+ ++ E + + KE +
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311
Query: 462 VKIQRLEKLCRALQTER 478
K Q ++L R + E+
Sbjct: 1312 RKSQEEKQLLREEREEK 1328
Score = 62.0 bits (149), Expect = 1e-09
Identities = 81/387 (20%), Positives = 170/387 (43%), Gaps = 41/387 (10%)
Query: 143 EEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAE---L 199
EE + S + DR R ++K + + ++ Q L ++ +K+ E L
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627
Query: 200 LEE------HRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKL--ESLCRELQRH 251
L+E HR + + L ++ Q + + + LR + + +L E ++L+R
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQ 1687
Query: 252 NRSLKEEGVQRAREEEEKRKEVTSHF-----QVTLNDIQLQMEQHNERNSKLRQENMELA 306
R K R E++ +R+E F Q+ +++ + + + + QE +
Sbjct: 1688 ERDRKF----REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ 1743
Query: 307 ERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEA 366
ER +K++E+ +LR E + + L++Q D K ++ +++ +E EE+ R ++ K
Sbjct: 1744 ERYRKILEEEQLRPER-----EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR 1798
Query: 367 VESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLE 426
E Q E ++E L+ Q ++EE Q L + + +QE + ++ + E
Sbjct: 1799 EEEQLRQE---REEQQLRPQQRDGKYRWEEEQLQLEEQEQ---RLRQERD---RQYRAEE 1849
Query: 427 KETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQ 486
+ T +SR E + L + E+K +++E + + I+R +K + +R+ ++
Sbjct: 1850 QFATQEKSRRE--EQELWQEEEQKRRQERERKLREEHIRRQQK-----EEQRHRQVGEIK 1902
Query: 487 DLSAGGQGSLTDSGPERRPEGPGAQAP 513
G G L + G + P +P
Sbjct: 1903 SQEGKGHGRLLEPGTHQFASVPVRSSP 1929
Score = 51.6 bits (122), Expect = 2e-06
Identities = 68/333 (20%), Positives = 152/333 (45%), Gaps = 38/333 (11%)
Query: 132 EKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAA 191
E+ + +P E +Q + +++ RR Q+ ++ + +E L + EE+L
Sbjct: 617 EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREE------EEERLEQ 670
Query: 192 LCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRH 251
K+ EH +++ +L +++Q Q ++ ++ K + + E+ R+ + +
Sbjct: 671 RLKR------EHEEERREQELAEEEQEQA---RERIKSRIPKWQW-QLESEADARQSKVY 720
Query: 252 NRSLKEEGVQRAREEE--EKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAER- 308
+R K+EG +R +E+E +R+E +Q + Q E+ R+ + + E +ER
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 309 LKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVE 368
++L + LRE+ +Q + + Q+ Q L E EE+ QR ++ E
Sbjct: 781 RQRLSARPPLREQR---------ERQLRAEERQQREQRFLPEEEEKEQRR-----RQRRE 826
Query: 369 SQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKE 428
++ + ++++E +++ A ++ +E ++ L + E QE + K +LE+E
Sbjct: 827 REKELQFLEEEEQLQRRERA---QQLQEEEDGLQEDQE--RRRSQEQRRDQKWRWQLEEE 881
Query: 429 TTMYRSRWESSNKALLEMAEEKTVRDKELEGLQ 461
R + ++ +E+ + +E E LQ
Sbjct: 882 RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQ 914
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 75.9 bits (185), Expect = 9e-14
Identities = 88/396 (22%), Positives = 173/396 (43%), Gaps = 35/396 (8%)
Query: 96 GEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRD 155
G Q + + +K+R ++ E T K + D TEE+R
Sbjct: 778 GSISLQETRRQKKTLKKTRKFIVDGVEVSVTT----SKIVTDSDSKTEELR--------- 824
Query: 156 HRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYA-ELLEEHRNSQKQMKLLQ 214
R QE ++ + L KE Q LN S +++ + +++ E++ + R ++++ L+
Sbjct: 825 FLRRQELRELRFLQKEEQRAQQQLN--SKLQQQREQIFRRFEQEMMSKKRQYDQEIENLE 882
Query: 215 KKQSQLVQ--EKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKE 272
K+Q Q ++ E++H +A + + E +EL + LK + E E+ KE
Sbjct: 883 KQQKQTIERLEQEHTNRLRDEAKRIKGEQE---KELSKFQNMLKNRKKEVINEVEKAPKE 939
Query: 273 VTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDL 332
+ + +L QH + ++++ EL LKK+I+Q + +I++ +
Sbjct: 940 LRKELMKRRKE-ELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNN-- 996
Query: 333 QQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQ---RMCELMKQQETHLKQQLAL 389
+QQL+ A+ + + E EERH +EK LLK+ ++ Q + +L+K+ E +Q
Sbjct: 997 KQQLMRAR----EAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRY 1052
Query: 390 YTEKFEEFQNTLSKSSEVFTTFKQEMEK----MTKKIKKLEKETTMYRSRWESSNKALLE 445
EE +N ++ ++ K M KK ++ T + R + A E
Sbjct: 1053 NQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQE 1112
Query: 446 MAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDL 481
+K R + + + +++ L+ C A E + L
Sbjct: 1113 EKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQL 1148
Score = 45.8 bits (107), Expect = 1e-04
Identities = 78/423 (18%), Positives = 169/423 (39%), Gaps = 36/423 (8%)
Query: 94 GPGEDGAQGEPAEPEDAEKSRTYVARNGEP---EPTPVVNGEKEPSKGDPNTEEIRQSDE 150
GP G + P + E E + +N E +++ +EP G EEI +S
Sbjct: 591 GPEAGGTKEVPIK-EIVEMNEIEEGKNKEQAINSSENIMDINEEP--GTTEGEEITESSS 647
Query: 151 VGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQM 210
+ + R K LG E+ + + ++++ KK E+ + ++ Q
Sbjct: 648 TEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQP 707
Query: 211 KLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLC---RELQRHNRSLKEEGVQRAREEE 267
L+ + GE+ + + + SK E++ E + N + G
Sbjct: 708 VLIPSINI------NSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSI 761
Query: 268 EKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQ------ENMELAERLKKLIEQYELREE 321
+ ++S T + + +++ + L++ + +E++ K++ + + E
Sbjct: 762 DLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTE 821
Query: 322 HIDKVFKHKDLQQQLVDAKLQQAQEML--KEAEERHQ----REKDFLLKEAVESQRMCEL 375
+ + + + + + + + Q+AQ+ L K ++R Q E++ + K+ Q + L
Sbjct: 822 ELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENL 881
Query: 376 MKQQETHLKQQLALYTEKFE--------EFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEK 427
KQQ+ +++ +T + E + LSK + K+E+ +K K +
Sbjct: 882 EKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELR 941
Query: 428 ETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQD 487
+ M R + E + + E + +EL+G KI + +K ER LN + Q
Sbjct: 942 KELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQK-AELANIERECLNNKQQL 1000
Query: 488 LSA 490
+ A
Sbjct: 1001 MRA 1003
Score = 40.4 bits (93), Expect = 0.004
Identities = 57/264 (21%), Positives = 108/264 (40%), Gaps = 35/264 (13%)
Query: 143 EEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTL-----NTLSTPEEKLAALCKKYA 197
EE+ QS +++ + Q+++ L K I L L+ ++ + A
Sbjct: 950 EELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIW 1009
Query: 198 ELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKE 257
EL E H + Q+ L Q+ + Q ++ L H K ++QR+N+ L E
Sbjct: 1010 ELEERHLQEKHQL-LKQQLKDQYFMQRHQLLKRHEKET----------EQMQRYNQRLIE 1058
Query: 258 E-----GVQRAREEEEKRKEVTSHFQVTLNDIQLQM----EQHNER------NSKLRQEN 302
E +RAR + +R E + + +++ +Q ++ + RQ+N
Sbjct: 1059 ELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKN 1118
Query: 303 MELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFL 362
+A+ K + +L+ + V + LQ + ++ + LKE +E H +E
Sbjct: 1119 ERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQE---- 1174
Query: 363 LKEAVESQRMCELMKQQETHLKQQ 386
LKE E R + ++E K Q
Sbjct: 1175 LKEWREKLRPRKKTLEEEFARKLQ 1198
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 75.5 bits (184), Expect = 1e-13
Identities = 96/420 (22%), Positives = 174/420 (41%), Gaps = 49/420 (11%)
Query: 143 EEIRQSDEVGDRDHRRP--QEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELL 200
++++ ++ HR Q K+ A GL E+ + L L +K+A + +L
Sbjct: 1368 QQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLR 1427
Query: 201 EEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGV 260
E + +Q+ +L+K L +E RG +A L R LE EL + +E
Sbjct: 1428 AEKASYAEQLSMLKKAHGLLAEEN---RGLGERANLGRQFLEV---ELDQAREKYVQELA 1481
Query: 261 QRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELRE 320
+ E + EV Q T ++++ ++ K+ +E E +KL Q E E
Sbjct: 1482 AVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLE 1541
Query: 321 EHIDKVFKHKDLQQ-QLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQ 379
VF+ + +Q + + KL + + A + Q++ + + ESQ+ + ++ Q
Sbjct: 1542 -----VFQREQTKQVEELSKKLADSDQ----ASKVQQQKLKAVQAQGGESQQEAQRLQAQ 1592
Query: 380 ETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQ---EMEKMTKKIKKLEKETTMYRSRW 436
L+ QL+ + E ++ + K+ + KQ E+++ + +++L+KE
Sbjct: 1593 LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKE-------- 1644
Query: 437 ESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRV----QDLSAGG 492
NK L AE EL+ +K + E+ CR L + L +V Q L G
Sbjct: 1645 ---NKELRAEAER---LGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLG 1698
Query: 493 QGSL-TDSGPERRPEGPGAQAPSSPRVTEAPCYPGA--------PSTEASGQTGPQEPTS 543
+ + TD+ R P+ Q S + C G P T+ G + P EP S
Sbjct: 1699 KFQVATDALKSREPQAK-PQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPAS 1757
Score = 60.1 bits (144), Expect = 5e-09
Identities = 104/511 (20%), Positives = 217/511 (42%), Gaps = 78/511 (15%)
Query: 60 ARTAQSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVAR 119
A+T+ + A R+ +E LSR++E++ + CV+ + E AQ + AE E R
Sbjct: 634 AQTSVTQAQREKAE-LSRKVEELQA--CVETARQEQHE--AQAQVAELE-------LQLR 681
Query: 120 NGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTL 179
+ + + T +E + + +++S +V + ++++ A L ++ + +
Sbjct: 682 SEQQKATEKERVAQEKDQLQEQLQALKESLKV-TKGSLEEEKRRAADALEEQ----QRCI 736
Query: 180 NTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQ-EKDHLRGEHSKAVLAR 238
+ L L K+ + LEE R +K ++ ++ + Q E + LR E ++A+ A+
Sbjct: 737 SELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQ 796
Query: 239 SKLESLCREL--------QRHNRSLKEEG----------------VQRAREE----EEKR 270
ES C +L +R+ S +EE ++AR+E +EK
Sbjct: 797 HTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKV 856
Query: 271 KEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHK 330
+ SH ++ ++ Q ++ + + ++ Q+ E R +KL + +E + K
Sbjct: 857 AGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEV 916
Query: 331 DLQQQLVDAKLQQ----AQEMLKEAEERHQREKDFLLKEAVESQRMCELM---------- 376
+ LV +Q ++E++KE R+ ++L E + ++ C
Sbjct: 917 ARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL--EEQQGRQFCSTQAALQAMEREA 974
Query: 377 KQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQE---------MEKMTKKIKKLEK 427
+Q L++ A E + Q + QE +EK + ++
Sbjct: 975 EQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRL 1034
Query: 428 ETTMYRSRWE--SSNKALLEMAEEKTVRDKELEGLQ----VKIQRLEKLCRALQTERNDL 481
+ + R E + +AL EK +D+EL L+ +I+ LE+L + ++ + L
Sbjct: 1035 QNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQL 1094
Query: 482 NKRVQDLSAGGQGSLTDSGPERRPEGPGAQA 512
K+ ++ A G G+ +++ P GP +A
Sbjct: 1095 AKKEKE-HASGSGAQSEAAGRTEPTGPKLEA 1124
Score = 60.1 bits (144), Expect = 5e-09
Identities = 84/398 (21%), Positives = 170/398 (42%), Gaps = 46/398 (11%)
Query: 106 EPEDAEKSRTYVARNGEP-EPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKK 164
E E + +R + + GE E +V E E S+ + Q++ + + ++
Sbjct: 1231 EEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNS----ARAAER 1286
Query: 165 AKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEK 224
+ L +E+ L + E L AE EE +++K Q+K Q Q
Sbjct: 1287 SSALREEVQSLREEAEKQRVASENLRQELTSQAERAEE---LGQELKAWQEKFFQKEQAL 1343
Query: 225 DHLRGEHSKAVLARSKL---ESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTL 281
L+ EH+ S+L + LC++LQ + ++ R REE E+ K+ + L
Sbjct: 1344 STLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK----RHREELEQSKQAAGGLRAEL 1399
Query: 282 NDIQLQMEQ---------HNERNSK-LRQENMELAERLKKLIEQYELREEHIDKVFKHKD 331
Q ++ + ER ++ LR E AE+L L + + L E + + +
Sbjct: 1400 LRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERAN 1459
Query: 332 LQQQLVDAKLQQAQEMLKEAEERHQREKDFLL----KEAVESQRMCELMKQQETHLKQQL 387
L +Q ++ +L QA+E + + + + L +EA + R E+M + K ++
Sbjct: 1460 LGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKV 1519
Query: 388 ALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMA 447
++F+E + L+ E F++E TK++++L K+ L +
Sbjct: 1520 LEERQRFQEERQKLTAQVEQLEVFQRE---QTKQVEELSKK--------------LADSD 1562
Query: 448 EEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRV 485
+ V+ ++L+ +Q + ++ + LQ + N+L ++
Sbjct: 1563 QASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQL 1600
Score = 57.0 bits (136), Expect = 4e-08
Identities = 76/384 (19%), Positives = 156/384 (40%), Gaps = 42/384 (10%)
Query: 139 DPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPE--------EKLA 190
D TE+ + ++ K + + L LN L+ EK A
Sbjct: 301 DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQA 360
Query: 191 ALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHL-------RGEHSKAVLARSKLES 243
L K+ + L++ + +++ ++LQ K SQL + L +GE VL L+
Sbjct: 361 QLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQ 420
Query: 244 LCRELQRHNRSLK--------EEGVQRAR------EEEEKRKEVTSHFQVTLNDIQLQME 289
L +N L+ E G Q A+ EE++++++S + D+Q +
Sbjct: 421 EAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSS----LITDLQSSIS 476
Query: 290 QHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLK 349
++ +L Q + RL + ++ + +D Q+L K Q ++ +
Sbjct: 477 NLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQD--QELAGLKQQAKEKQAQ 534
Query: 350 EAEERHQREKDFL-LKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVF 408
A+ Q+E+ L+ VE ++ +KQ+E LK+ ++ L+ ++E
Sbjct: 535 LAQTLQQQEQASQGLRHQVE--QLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEER 592
Query: 409 TTFKQEMEKMTKKIKKLEKETT----MYRSRWESSNKALLEMAEEKTVRDKELEGLQVKI 464
+E + K+++ LEKE + + + + +N+A T +E L K+
Sbjct: 593 EASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKV 652
Query: 465 QRLEKLCRALQTERNDLNKRVQDL 488
+ L+ + E+++ +V +L
Sbjct: 653 EELQACVETARQEQHEAQAQVAEL 676
Score = 52.8 bits (125), Expect = 8e-07
Identities = 109/528 (20%), Positives = 218/528 (41%), Gaps = 83/528 (15%)
Query: 42 EAEGPGSSQAPRKPEGAQARTAQ-----SGALRDVSEELS---RQLEDILSTYCVDNNQG 93
+ E G Q ++ + A+T Q S LR E+LS +Q E L V Q
Sbjct: 518 DQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE--VAEKQE 575
Query: 94 GPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGD 153
+D AQ E+ E S R+ + + EK +K + ++++ ++E D
Sbjct: 576 ATRQDHAQQLATAAEEREASLR--ERDAALKQLEALEKEKA-AKLEILQQQLQVANEARD 632
Query: 154 RDHRRPQEKKKAKG-LGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKL 212
+ ++ K L +++ L + T + + A + AEL + R+ Q++
Sbjct: 633 SAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQA---QVAELELQLRSEQQKAT- 688
Query: 213 LQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKE 272
++ ++ QEKD L+ +L++L L+ SL+EE +RA + E+++
Sbjct: 689 ---EKERVAQEKDQLQ----------EQLQALKESLKVTKGSLEEEK-RRAADALEEQQR 734
Query: 273 VTSHFQVTLNDIQLQMEQHNERNSKLRQENME---LAERLKKLIEQYELREEHIDKVFKH 329
S + + +EQH +L +E L RL++L E ++ E + +
Sbjct: 735 CISELKAETRSL---VEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAE 791
Query: 330 KDLQQQLVDAKLQQAQEMLKEAEERHQ-------------REKDFLLKE----------- 365
Q +++ +Q + + ER++ +E+ LKE
Sbjct: 792 AMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQE 851
Query: 366 ------AVESQRMCELMKQQE--THLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEK 417
+ES ++ +QQ L LA ++ +E + K ++ +T +++M
Sbjct: 852 AKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAA 911
Query: 418 MTKKIKKLEKETTMYRSRWESSNKALLEMAEEKT-VRDKELEGLQVKIQR----LEKLCR 472
+K++ +LE T+ R E A E+ +E D++ E L+ + R + +
Sbjct: 912 TSKEVARLE---TLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQ 968
Query: 473 ALQTERNDLNKRVQDLSAGGQGSLTDSGPERRPEGPGAQAPSSPRVTE 520
A++ E + ++ L A +L +S +++ E G Q R+T+
Sbjct: 969 AMEREAEQMGNELERLRA----ALMESQGQQQEE-RGQQEREVARLTQ 1011
Score = 51.6 bits (122), Expect = 2e-06
Identities = 105/483 (21%), Positives = 201/483 (41%), Gaps = 53/483 (10%)
Query: 22 QPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLED 81
+ AG +G + R Q A +AE ++ R+ E A+A AQ A + E+L +++
Sbjct: 759 EERAGRKGLEARLQQLGEAHQAE----TEVLRR-ELAEAMAAQHTAESEC-EQLVKEVAA 812
Query: 82 ILSTYCVDNNQGGPGEDGAQGEP---AEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKG 138
Y +++Q + GA + E+ EK+R + KE G
Sbjct: 813 WRERY--EDSQQEEAQYGAMFQEQLMTLKEECEKARQELQE------------AKEKVAG 858
Query: 139 DPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAE 198
+ E++ S + + + + + ++ + + LST +EK+AA K+ A
Sbjct: 859 IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918
Query: 199 LLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEE 258
L R + +Q + + +LV+E G+ L + C Q ++++ E
Sbjct: 919 LETLVRKAGEQQETASR---ELVKEPARA-GDRQPEWLEEQQGRQFC-STQAALQAMERE 973
Query: 259 GVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYEL 318
Q E E R + ++ Q +Q ER + R+ ER + Q +L
Sbjct: 974 AEQMGNELERLRAAL----------MESQGQQQEERGQQEREVARLTQERGRA---QADL 1020
Query: 319 REEHIDKVFKHKDLQQQLVDAKLQQA--QEMLKEA-EERHQREKDFLLKEAVESQRMCEL 375
E + LQ L + +++ A QE L A E+ ++++ +E+ ++ EL
Sbjct: 1021 ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL 1080
Query: 376 MKQQET--HLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYR 433
+ ++T LK+QLA ++ S+++ ++E + ++ KLE++ +
Sbjct: 1081 EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ 1140
Query: 434 SRWESSNKALLEMAEEKTVRDKELEGLQ----VKIQRLEKLCRALQTERNDL---NKRVQ 486
+ +S ++L + RD LE LQ K Q L AL + + +L +VQ
Sbjct: 1141 EQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ 1200
Query: 487 DLS 489
D S
Sbjct: 1201 DHS 1203
Score = 49.7 bits (117), Expect = 7e-06
Identities = 76/382 (19%), Positives = 158/382 (41%), Gaps = 38/382 (9%)
Query: 148 SDEVGDRDHRRPQEKKKAKGLGK---EITLLMQTLNTLSTPEEKLAALCKKYAELLEEHR 204
+DE +RD + + K L + +I ++ Q ++ L+ EK AA + EL E
Sbjct: 224 ADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRD 283
Query: 205 NSQ----------KQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRS 254
++ KQ + L+ ++SQ+ ++ + L E+ + S ++LQ
Sbjct: 284 KNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNE 343
Query: 255 LKEEGVQRAREEEEKRKEVTSHFQVTLND----------IQLQMEQHNERNSKLRQEN-- 302
L EE + +E EK+ ++ L D +Q ++ Q E S+L Q+N
Sbjct: 344 LTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQL-QDNPP 402
Query: 303 MELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEER--HQREKD 360
E E L +++ L++E + LQ ++ + ++ Q+ K ER + EK
Sbjct: 403 QEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQ 462
Query: 361 FLLKEAVESQRMCELMKQQETHLKQQL----ALYTEKFEEFQNTLSKSSEVFTTFKQEME 416
L + Q + Q + L+Q A T + + L+ + QE+
Sbjct: 463 QLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELA 522
Query: 417 KMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQT 476
+ ++ K+ + + + E +++ L E+ + L+ K Q+L+++ +
Sbjct: 523 GLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS------SSLKQKEQQLKEVAEKQEA 576
Query: 477 ERNDLNKRVQDLSAGGQGSLTD 498
R D +++ + + SL +
Sbjct: 577 TRQDHAQQLATAAEEREASLRE 598
Score = 46.2 bits (108), Expect = 8e-05
Identities = 73/357 (20%), Positives = 158/357 (44%), Gaps = 38/357 (10%)
Query: 154 RDHRRPQEKKKAK-GLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKL 212
+DH + +++ KA+ G++ +L +S+ EE+++ L ++ E E K++ +
Sbjct: 1200 QDHSKAEDEWKAQVARGRQEAERKNSL--ISSLEEEVSILNRQVLEK-EGESKELKRLVM 1256
Query: 213 LQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKE 272
+ ++SQ ++E+ L + + AR+ S +L+EE VQ REE EK++
Sbjct: 1257 AESEKSQKLEERLRLLQAETASNSARAAERS---------SALREE-VQSLREEAEKQRV 1306
Query: 273 VTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDL 332
+ + + L + E+ + +++ + + L L ++ + + ++ K L
Sbjct: 1307 ASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHL 1366
Query: 333 QQQLVDAKLQQAQEMLKEAEE-------------RHQREKDFLL---KEAVESQRMCELM 376
QQL + + +E E+ R QRE L+ ++ E +R + +
Sbjct: 1367 CQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQL 1426
Query: 377 KQQETHLKQQLALYTEK---FEEFQNTLSKSSEVFTTFKQ-EMEKMTKK-IKKLEKETTM 431
+ ++ +QL++ + E L + + + F + E+++ +K +++L
Sbjct: 1427 RAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRAD 1486
Query: 432 YRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDL 488
+R + A E V + EG +VK+ LE+ R Q ER L +V+ L
Sbjct: 1487 AETRLAEVQREAQSTARELEVMTAKYEGAKVKV--LEERQR-FQEERQKLTAQVEQL 1540
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 74.7 bits (182), Expect = 2e-13
Identities = 74/344 (21%), Positives = 173/344 (50%), Gaps = 39/344 (11%)
Query: 143 EEIRQSDE-VGDRDHRRPQEKK---KAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAE 198
EE RQ +E + +++ R+ QE K + + + ++ + + + EEK+ +K E
Sbjct: 410 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ-EKIRE 468
Query: 199 LLEEHRNSQKQMKLLQKK---QSQLVQEKDHLRGEHSKAVLARSKL---ESLCRELQRHN 252
EE R Q++M ++K Q ++ ++K+ + + K K+ E RE +
Sbjct: 469 --EEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKI 526
Query: 253 RSLKEE---GVQRAREEEEK-RKEVTSHFQVTLNDIQLQMEQHNE---RNSKLRQENMEL 305
R +E+ ++ RE+EE R+E H Q + + + + EQ ++ + K+R++ ++
Sbjct: 527 REQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKV 586
Query: 306 AERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKE 365
+ +K+ EQ E R+E +K++K ++ K+++ +E ++E EE+ + +++ + ++
Sbjct: 587 WRQEEKIREQEEKRQEQEEKMWKQEE--------KIREQEEKIQEQEEKIREQEEKIREQ 638
Query: 366 AVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKL 425
+Q E M +QE + +Q EK +E + T+ + E ++ + KKI++
Sbjct: 639 EEMTQEQEEKMGEQEEKMCEQ----EEKMQEQEETMWRQEE-------KIREQEKKIREQ 687
Query: 426 EKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEK 469
E++ + + + E E+ ++++++ + K++R E+
Sbjct: 688 EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 731
Score = 73.2 bits (178), Expect = 6e-13
Identities = 71/302 (23%), Positives = 157/302 (51%), Gaps = 18/302 (5%)
Query: 175 LMQTLNTLSTPEEK----LAALCKKYAEL-LEEHRNSQKQMKLLQKKQSQLVQEKDHLRG 229
L Q L+ ++T ++K + L K+ L LE +RN+ +L ++K ++L ++ +
Sbjct: 177 LEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEEL-KEKNAKLQEKLQLVES 235
Query: 230 EHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQME 289
E S+ L ++ L R+L+R L ++ +Q E + KE+ S +Q Q+E
Sbjct: 236 EKSEIQL---NVKELKRKLERAKLLLPQQQLQA--EADHLGKELQS----VSAKLQAQVE 286
Query: 290 QHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLK 349
+ NE ++L Q+ E R ++ I+++E + + ++ + ++ + + + K+++ +EM+
Sbjct: 287 E-NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW 345
Query: 350 EAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFT 409
E EE+ +R+++ + ++ + +R E+M ++E +++Q + EK E+ + K E
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 405
Query: 410 TFKQEMEKM-TKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLE 468
+QE ++ +KI++ EK W K + E E+ ++K++ + KI E
Sbjct: 406 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK-IREQEEKIREQEKKMWRQEEKIHEQE 464
Query: 469 KL 470
K+
Sbjct: 465 KI 466
Score = 72.0 bits (175), Expect = 1e-12
Identities = 63/318 (19%), Positives = 162/318 (50%), Gaps = 30/318 (9%)
Query: 186 EEKLAALCKKYAEL-----LEEHRNSQKQMKLLQKKQSQ---LVQEKDHLRGEHSKAVLA 237
EEK+ L +K E EE R +++++ +K+Q Q + ++++ +R + K
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI--- 446
Query: 238 RSKLESLCRELQR-HNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNS 296
R + + + R+ ++ H + E +R +EE R+E H Q +I Q E+ +E+
Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQ---EEIWRQKEKMHEQEE 503
Query: 297 KLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQ 356
K+R++ ++ + +K+ EQ E E +K+++ ++ K+++ +EM +E E+ H+
Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEE--------KIREQEEMWREEEKMHE 555
Query: 357 REKDFLLKEAVESQ----RMCELMKQQETHL---KQQLALYTEKFEEFQNTLSKSSEVFT 409
+EK + ++ E + R E +++QE + ++++ EK +E + + K E
Sbjct: 556 QEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIR 615
Query: 410 TFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEK 469
++++++ +KI++ E++ + + + E E+ ++++++ + + R E+
Sbjct: 616 EQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEE 675
Query: 470 LCRALQTERNDLNKRVQD 487
R + + + +++++
Sbjct: 676 KIREQEKKIREQEEKIRE 693
Score = 69.3 bits (168), Expect = 8e-12
Identities = 60/308 (19%), Positives = 152/308 (49%), Gaps = 19/308 (6%)
Query: 143 EEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKL---AALCKKYAEL 199
E+IR+ ++ R + E++K + K Q + EEK+ + ++ ++
Sbjct: 444 EKIREQEKKMWRQEEKIHEQEKIREEEKR-----QEQEEMWRQEEKIHEQEEIWRQKEKM 498
Query: 200 LEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKL---ESLCRELQRHNRSLK 256
E+ +KQ + + +++ ++ ++++ +R + K K+ E + RE ++ + K
Sbjct: 499 HEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEK 558
Query: 257 --EEGVQRAREE-----EEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERL 309
EE ++ +E+ EEK +E I+ Q E+ E+ K+ ++ ++ E+
Sbjct: 559 IWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQE 618
Query: 310 KKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVES 369
+K+ EQ E E +K+ + +++ Q+ + K+ + +E + E EE+ Q +++ + ++ +
Sbjct: 619 EKIQEQEEKIREQEEKIREQEEMTQEQ-EEKMGEQEEKMCEQEEKMQEQEETMWRQEEKI 677
Query: 370 QRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKET 429
+ + +++QE +++Q + E+ E+ K E +++ EKM ++ +K+ ++
Sbjct: 678 REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 737
Query: 430 TMYRSRWE 437
R + E
Sbjct: 738 VRLRQQEE 745
Score = 64.7 bits (156), Expect = 2e-10
Identities = 75/372 (20%), Positives = 172/372 (46%), Gaps = 40/372 (10%)
Query: 132 EKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAA 191
E E S+ N +E+++ E + Q + +A LGKE+ + L E
Sbjct: 234 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 293
Query: 192 LCKKYAELL-EEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQR 250
L ++ E + + Q+ + +Q+++ ++ ++++ +R + K + +++R
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353
Query: 251 HNRSLKEEGVQRAREEE---EKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAE 307
+ E+ + R+EE EK +++ + Q E E+ K+R+ ++ E
Sbjct: 354 QEEMMWEKEEKMRRQEEMMWEKEEKM-----------RRQEEMMWEKEEKIRELEEKMHE 402
Query: 308 RLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEER------------- 354
+ +K+ EQ E R+E +K+ + + Q+Q +AK+ + +E ++E EE+
Sbjct: 403 Q-EKIREQEEKRQEE-EKIREQEKRQEQ--EAKMWRQEEKIREQEEKIREQEKKMWRQEE 458
Query: 355 --HQREKDFLLKEAVESQRMCELMKQQE-THLKQQLALYTEKFEEFQNTLSKSSEVFTTF 411
H++EK ++E + Q E+ +Q+E H ++++ EK E + + K E
Sbjct: 459 KIHEQEK---IREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQ 515
Query: 412 KQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLC 471
++++ + +KI+ E+E M+R + + + EEK +++ + + ++ +K+
Sbjct: 516 EEKIREQEEKIR--EQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMW 573
Query: 472 RALQTERNDLNK 483
R + R K
Sbjct: 574 RQEEKIREQEEK 585
Score = 64.3 bits (155), Expect = 3e-10
Identities = 61/289 (21%), Positives = 135/289 (46%), Gaps = 18/289 (6%)
Query: 143 EEIRQSDEVGDRDHRRPQEKK--KAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELL 200
E+IR+ ++ +++ QE+K + + + ++ + + + EEK+ +K E
Sbjct: 464 EKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQE 523
Query: 201 EEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGV 260
E+ R +++M +Q + ++E++ + E K E R+ Q +EE +
Sbjct: 524 EKIREQEEKMW----RQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKI 579
Query: 261 -----------QRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERL 309
++ RE+EEKR+E I+ Q E+ E+ K+R++ ++ E+
Sbjct: 580 REQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQE 639
Query: 310 KKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVES 369
+ EQ E E +K+ + ++ Q+ + +Q +E ++E E++ + +++ + ++
Sbjct: 640 EMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQ-EEKIREQEKKIREQEEKIREQEEMM 698
Query: 370 QRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKM 418
Q E M +QE + +Q E+ E+ + K E +Q+ EKM
Sbjct: 699 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKM 747
Score = 55.5 bits (132), Expect = 1e-07
Identities = 51/254 (20%), Positives = 127/254 (50%), Gaps = 21/254 (8%)
Query: 146 RQSDEVGDRDHR-RPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHR 204
RQ +++ +++ + R QE+K + K ++ + EEK+ K + E + +
Sbjct: 514 RQEEKIREQEEKIREQEEKMWRQEEK-----IREQEEMWREEEKMHEQEKIWEEEKRQEQ 568
Query: 205 NSQ--KQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQR 262
+ +Q + +++++ ++ ++++ +R + K K+ +++ ++E+ ++
Sbjct: 569 EDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQE-EK 627
Query: 263 AREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEH 322
RE+EEK +E Q + Q E+ E+ K++++ + + +K+ EQ + E
Sbjct: 628 IREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQ 687
Query: 323 IDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETH 382
+K+ + +++ Q+ + K+ + +E + E EE+ Q +++ + +R E M +QE
Sbjct: 688 EEKIREQEEMMQEQ-EEKMWEQEEKMCEQEEKMQEQEE-------KMRRQEEKMWEQEVR 739
Query: 383 LKQQLALYTEKFEE 396
L+QQ EK +E
Sbjct: 740 LRQQ----EEKMQE 749
Score = 52.4 bits (124), Expect = 1e-06
Identities = 41/236 (17%), Positives = 114/236 (48%), Gaps = 37/236 (15%)
Query: 143 EEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEE 202
E++ + +++ + + R+ QE K + + + EEK+ ++ ++ E+
Sbjct: 551 EKMHEQEKIWEEEKRQEQEDK-----------MWRQEEKIREQEEKV---WRQEEKIREQ 596
Query: 203 HRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQR 262
Q+Q + + K++ ++ ++++ ++ + K K+ Q + E+ ++
Sbjct: 597 EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQE-EK 655
Query: 263 AREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEH 322
E+EEK +E Q E + K+R++ ++ E+ +K+ EQ E+ +E
Sbjct: 656 MCEQEEKMQE--------------QEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQ 701
Query: 323 IDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQ 378
+K+++ ++ K+ + +E ++E EE+ +R+++ + ++ V ++ E M++
Sbjct: 702 EEKMWEQEE--------KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 44.3 bits (103), Expect = 3e-04
Identities = 35/185 (18%), Positives = 89/185 (48%), Gaps = 23/185 (12%)
Query: 146 RQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRN 205
RQ +++ +++ +R ++++K + EEK+ +K E E+ R
Sbjct: 588 RQEEKIREQEEKRQEQEEK-----------------MWKQEEKIREQEEKIQEQEEKIRE 630
Query: 206 SQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARS-KLESLCRELQRHNRSLKEEGVQRAR 264
+++++ +Q ++ QE++ GE + + + K++ + R ++E+ ++ R
Sbjct: 631 QEEKIR----EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQE-KKIR 685
Query: 265 EEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHID 324
E+EEK +E Q + Q E+ E+ K++++ ++ + +K+ EQ + +
Sbjct: 686 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 745
Query: 325 KVFKH 329
K+ +H
Sbjct: 746 KMQEH 750
Score = 32.3 bits (72), Expect = 1.1
Identities = 33/146 (22%), Positives = 69/146 (47%), Gaps = 13/146 (8%)
Query: 350 EAEERHQREKDFLLKEAVESQ-RMCELMKQQETHLKQQLALYTEKFE------EFQNTLS 402
E E++ + L+ +E+Q ++ Q+T L Q+ALY + E ++ +S
Sbjct: 108 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTEL--QMALYYSQHAVKQLEGEARDLIS 165
Query: 403 KSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQV 462
+ + + F E+E+ + +K+ Y AL T+ D+EL+
Sbjct: 166 RLHDSWK-FAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 224
Query: 463 KIQRLEKLCRALQTERNDLNKRVQDL 488
K+Q EKL + +++E++++ V++L
Sbjct: 225 KLQ--EKL-QLVESEKSEIQLNVKEL 247
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 73.9 bits (180), Expect = 3e-13
Identities = 95/374 (25%), Positives = 160/374 (42%), Gaps = 50/374 (13%)
Query: 160 QEKKKAKGLGKE--ITLLMQTLNTLSTPEEKLAALC--KKYAELLEEHRNSQKQMKLLQ- 214
++ KK+ L KE I LL L E+ + L K E+LE H S + K+L+
Sbjct: 67 RKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRV 126
Query: 215 -KKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRS---LKEEGVQRAREEEEKR 270
+ + L QEK + K + +LE +E R L E+ +R E E
Sbjct: 127 LHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENE 186
Query: 271 KEVTSHFQVTLNDIQLQMEQHNERNSKLRQENM--------ELAERLKKLIEQY------ 316
K + + +D +EQ ER KL ++ E A+RL KL ++
Sbjct: 187 KHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSF 246
Query: 317 -----ELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAV---- 367
+ R+ HI+++ Q L KL++ +E LK + + ++ LLK V
Sbjct: 247 ALMLVDERQMHIEQLGLQSQKVQDLTQ-KLREEEEKLKAITSKSKEDRQKLLKLEVDFEH 305
Query: 368 -------ESQRMCELMKQQETHLKQ---QLALYTEKFEEFQNTLSKSSEVFTTFKQEMEK 417
E + M + QE+H +Q +L T++ EE + T + ++E+++
Sbjct: 306 KASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKA----EEELQE 361
Query: 418 MTKKIKKLEKETTMYRSRWESSNKALLEMA---EEKTVRDKELEGLQVKIQRLEKLCRAL 474
+ KI K E + + E+ K +LEM EE T + + L+ K+Q E + L
Sbjct: 362 LRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKEL 421
Query: 475 QTERNDLNKRVQDL 488
+ E L KR+ +L
Sbjct: 422 RLEVEKLQKRMSEL 435
Score = 66.2 bits (160), Expect = 7e-11
Identities = 84/305 (27%), Positives = 140/305 (45%), Gaps = 45/305 (14%)
Query: 196 YAELLEEHRNSQKQMKLLQKKQSQLVQEKDH---LRGEHSKAVLARSKLESLCRELQRHN 252
+ LLE+ R K++ L Q+K Q +EK++ L + V +S L E Q H
Sbjct: 200 FTNLLEQERERLKKL-LEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHI 258
Query: 253 RSLK------EEGVQRAREEEEKRKEVTSHFQVT---LNDIQLQME--------QHNERN 295
L ++ Q+ REEEEK K +TS + L +++ E +H E N
Sbjct: 259 EQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMN 318
Query: 296 SKLRQE---NMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQ----EML 348
+KL + N +L +L L ++ E EE + K ++ Q+L D K+ + + ++
Sbjct: 319 AKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRD-KIAKGECGNSSLM 377
Query: 349 KEAEERHQR--EKDFLLKEAVESQRMC-ELMK--QQETHLKQQLALYTEKFEEFQNTLSK 403
E E +R E + +E +++ C EL K Q+E H ++L L EK ++ + L K
Sbjct: 378 AEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEK 437
Query: 404 SSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVK 463
E F+ K E ++ ++K EK T K LL E R KELE + +
Sbjct: 438 LEEAFSKSKSECTQLHLNLEK-EKNLT----------KDLLNELEVVKSRVKELECSESR 486
Query: 464 IQRLE 468
+++ E
Sbjct: 487 LEKAE 491
Score = 50.8 bits (120), Expect = 3e-06
Identities = 69/313 (22%), Positives = 128/313 (40%), Gaps = 73/313 (23%)
Query: 188 KLAALCKKYAELLEEHRNSQKQMKL----LQKKQSQLVQEKDHLRGEHSKAVLARSKLES 243
K + C++ + L+E + K+++L LQK+ S+L K A SK +S
Sbjct: 399 KTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSEL-----------EKLEEAFSKSKS 447
Query: 244 LCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENM 303
C +L + EK K +T L ++ ++++ S+L + +
Sbjct: 448 ECTQLHLN---------------LEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAEL 492
Query: 304 ELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLL 363
L + L KL K LVD + +++ +E + K+F
Sbjct: 493 SLKDDLTKL-----------------KSFTVMLVDERKNMMEKIKQEERKVDGLNKNF-- 533
Query: 364 KEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEK------ 417
VE ++ ++ ++ K+ L L +E E+ N + E+ K E EK
Sbjct: 534 --KVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSC 591
Query: 418 ---MTKK----IKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKL 470
+ KK I+++E+E T RSR + +E D +++ L ++I+RL+K
Sbjct: 592 SVDLLKKRLDGIEEVEREITRGRSR---------KGSELTCPEDNKIKELTLEIERLKKR 642
Query: 471 CRALQTERNDLNK 483
+ L+ DL K
Sbjct: 643 LQQLEVVEGDLMK 655
Score = 50.1 bits (118), Expect = 5e-06
Identities = 81/408 (19%), Positives = 165/408 (40%), Gaps = 49/408 (12%)
Query: 149 DEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQK 208
DE + + QE++K GL K + + K+ + +K L+EE + K
Sbjct: 510 DERKNMMEKIKQEERKVDGLNKNFKV----------EQGKVMDVTEK---LIEESKKLLK 556
Query: 209 QMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEE 268
+++K L +E+D L G+ S+L L++ ++E + R
Sbjct: 557 LKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSR 616
Query: 269 KRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFK 328
K E+T + ++ L++E+ +R L+Q + + +K E +L ++ + K
Sbjct: 617 KGSELTCPEDNKIKELTLEIERLKKR---LQQLEVVEGDLMKTEDEYDQLEQKFRTEQDK 673
Query: 329 HKDLQQQLVDAK--------LQQAQEMLKEAEERHQ------REKDFLLKEAVESQRMCE 374
L QQL + K +++ + + +EAE RH+ + +D + +++ E
Sbjct: 674 ANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHE 733
Query: 375 LMKQQE--THLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMY 432
LM +++ + L+ ++ ++F E +N + +E+E + + L
Sbjct: 734 LMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGR 793
Query: 433 R-------SRWESSNKALLEMAEEKT----VRDKELEGLQVKIQRLEKLCRALQTERNDL 481
R S ++ E AEE+T +R E + + L ++ ER+ +
Sbjct: 794 RMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHI-MSNLRQVGLKKPVERSSV 852
Query: 482 NKRVQDLSAGGQGSLTDS---GPERRPEGPGAQAPSSPRVTEAPCYPG 526
R A + ++ S +R GP PR +P +PG
Sbjct: 853 LDRYP--PAANELTMRKSWIPWMRKRENGPSITQEKGPRTNSSPGHPG 898
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 73.6 bits (179), Expect = 4e-13
Identities = 77/343 (22%), Positives = 152/343 (44%), Gaps = 34/343 (9%)
Query: 176 MQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAV 235
++ L +S EE++ A ++ ++ E+ ++ ++ ++ QSQL+ EK L+ +
Sbjct: 834 VKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET 893
Query: 236 LARSKLESLCRELQRHNRSLKE---EGVQRAREEEEKRKEVTSH---FQVTLNDIQLQME 289
++ E L L + L+E + R EEEE+ + + + Q + +++ Q+E
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 290 QHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVD----------- 338
+ KL+ E + +LKKL E+ + E+ K+ K K L + +
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013
Query: 339 -----AKLQQAQE-MLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTE 392
AKL+ E M+ + EER +RE+ K+ E ++ ++ T L Q+A
Sbjct: 1014 KSKSLAKLKNKHEAMITDLEERLRREE----KQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 393 KFEEFQNTLSKSSEVFTTFKQEMEKMT-------KKIKKLEKETTMYRSRWESSNKALLE 445
+ E + L+K E +E+ KKI++LE + + + ES + +
Sbjct: 1070 QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNK 1129
Query: 446 MAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDL 488
++K +ELE L+ +++ A Q R+ + V L
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNIL 1172
Score = 65.1 bits (157), Expect = 2e-10
Identities = 83/395 (21%), Positives = 157/395 (39%), Gaps = 74/395 (18%)
Query: 153 DRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLE-----EHRNSQ 207
+ R+ EK + K G L Q + E L KK EL E +Q
Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ 1098
Query: 208 KQMKL--LQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLK---EEGVQR 262
K M L +++ +SQ+ + ++ L E + +R+K E R+L +LK E+ +
Sbjct: 1099 KNMALKKIRELESQISELQEDLESERA----SRNKAEKQKRDLGEELEALKTELEDTLDS 1154
Query: 263 AREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEH 322
++E R + + ++ + + H + ++RQ++ + E L + +EQ + + +
Sbjct: 1155 TAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKAN 1214
Query: 323 IDKVFK---------------------HKDLQQQLVDAKLQQAQEMLKEAEERHQREKDF 361
++K + + +++ V+A+LQ+ Q E E D
Sbjct: 1215 LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADK 1274
Query: 362 LLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKK 421
+ K VE + L+ Q ++ + T+ F ++ L + E+ ++ ++ K
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKSSK----LTKDFSALESQLQDTQELLQEENRQKLSLSTK 1330
Query: 422 IKKLEKETTMYRSRWESSNKA---------------------------LLEMAEE-KTVR 453
+K++E E +R + E +A LE AEE K
Sbjct: 1331 LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 1390
Query: 454 DKELEGLQVK-------IQRLEKLCRALQTERNDL 481
K+LEGL + +LEK LQ E +DL
Sbjct: 1391 QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL 1425
Score = 60.5 bits (145), Expect = 4e-09
Identities = 90/409 (22%), Positives = 172/409 (42%), Gaps = 29/409 (7%)
Query: 124 EPTPVVNGEKEPSKGDPNTEEIRQSDEV-------GDRDHRRPQEKKKAKGLGKEITLLM 176
E T V E +K E ++EV GD +H+R + + + + L +
Sbjct: 1206 EQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGE 1265
Query: 177 QTLNTLSTPEEKLAALCKKYAELLEEHRN-SQKQMKLLQKKQSQLVQEKDHLRGEHSKAV 235
+ L+ KL LL + + S K K +SQL ++ L+ E+ + +
Sbjct: 1266 RVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKL 1325
Query: 236 LARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERN 295
+KL+ + E L+EE + A+ EK+ T H QV D++ +ME
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEE--EEAKHNLEKQI-ATLHAQVA--DMKKKMEDSVGCL 1380
Query: 296 SKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERH 355
+ +L + L+ L +++E + DK+ K K QQ +D L + A
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLE 1440
Query: 356 QREKDF---LLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFK 412
+++K F L +E S + E + E +++ E +L+++ E K
Sbjct: 1441 KKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK--------ETKALSLARALEEAMEQK 1492
Query: 413 QEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCR 472
E+E++ K+ + E E M S + K++ E+ + K ++++E ++ +++ LE +
Sbjct: 1493 AELERLNKQF-RTEMEDLM--SSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ 1549
Query: 473 ALQTERNDLNKRVQDLSAGGQGSLTDSGPERRPEGPGAQAPSSPRVTEA 521
A + + L +Q + A + L G + + E Q R EA
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDL--QGRDEQSEEKKKQLVRQVREMEA 1596
Score = 58.9 bits (141), Expect = 1e-08
Identities = 82/394 (20%), Positives = 164/394 (41%), Gaps = 54/394 (13%)
Query: 132 EKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKK-----KAKGLGKEITLLMQTLNTLSTPE 186
+ E K N +E+ + E + ++ Q +K K K L +E ++++ N E
Sbjct: 935 QAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEE-QIILEDQNCKLAKE 993
Query: 187 EKLAA--LCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESL 244
+KL + + L EE S+ KL K ++ + ++ LR E + R +LE
Sbjct: 994 KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ----RQELEKT 1049
Query: 245 CRELQRHNRSL--------------------KEEGVQRAR---EEEEKRKEVT----SHF 277
R+L+ + L KEE +Q A EEE +K +
Sbjct: 1050 RRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIREL 1109
Query: 278 QVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLV 337
+ ++++Q +E +K ++ +L E L+ L + E+ +D ++L+
Sbjct: 1110 ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL---EDTLDSTAAQQELR---- 1162
Query: 338 DAKLQQAQEMLKEAEERHQREKDFLLKEAVE--SQRMCELMKQ--QETHLKQQLALYTEK 393
+K +Q +LK+ E + + ++E + SQ + EL +Q Q +K L +
Sbjct: 1163 -SKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221
Query: 394 FEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVR 453
E + L+ +V K + E K KK+E + + ++ + E+A++ T
Sbjct: 1222 LENERGELANEVKVLLQGKGDSE---HKRKKVEAQLQELQVKFNEGERVRTELADKVTKL 1278
Query: 454 DKELEGLQVKIQRLEKLCRALQTERNDLNKRVQD 487
EL+ + + + + L + + L ++QD
Sbjct: 1279 QVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD 1312
Score = 58.5 bits (140), Expect = 1e-08
Identities = 75/360 (20%), Positives = 163/360 (45%), Gaps = 42/360 (11%)
Query: 168 LGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKL-LQKKQSQLVQEKDH 226
+GK + L ++ L E++ ++ + L+ +++ ++++ LQ ++Q E+D
Sbjct: 1516 VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQF--ERD- 1572
Query: 227 LRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQL 286
L+G ++ K + L R+++ L++E QR+ ++K ++ L D++
Sbjct: 1573 LQGRDEQS---EEKKKQLVRQVREMEAELEDERKQRSMAVAARKK-----LEMDLKDLEA 1624
Query: 287 QMEQHNERNSK----LRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQ 342
++ N+ + LR+ ++ + +++L + REE + + K + + + ++A++
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQA-KENEKKLKSMEAEMI 1683
Query: 343 QAQEMLKEAEE---RHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQN 399
Q QE L AE + Q+E+D L E S L +++ L+ ++A E+ EE Q
Sbjct: 1684 QLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQG 1743
Query: 400 TLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRS---RWESSNKALLEMAEEKTVRDKE 456
++K +I ++ + + RS + E++ + L +E V+ +E
Sbjct: 1744 NTE-------LINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQE 1796
Query: 457 LEG------------LQVKIQRLEKLCRALQTERNDLNKRVQDLSAGGQGSLTDSGPERR 504
+EG L+ KI +LE+ ER K+V+ + L ERR
Sbjct: 1797 MEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERR 1856
Score = 56.6 bits (135), Expect = 6e-08
Identities = 55/252 (21%), Positives = 117/252 (46%), Gaps = 35/252 (13%)
Query: 249 QRHNRSLKEEGVQRAREEE---EKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMEL 305
Q KEE + + RE++ E R Q L +LQ+++ + ++L E EL
Sbjct: 843 QEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEEL 902
Query: 306 AERL-------KKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQRE 358
RL +++ E R E ++ +H +++ + +Q+ +E L+E E Q+
Sbjct: 903 RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK- 961
Query: 359 KDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKM 418
L E V ++ + +++++ L+ Q ++ + ++ +++ FTT E E+
Sbjct: 962 ---LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAE----FTTNLTEEEEK 1014
Query: 419 TKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTER 478
+K + KL+ + ++A++ EE+ R+++ Q LEK R L+ +
Sbjct: 1015 SKSLAKLKNK-----------HEAMITDLEERLRREEKQR------QELEKTRRKLEGDS 1057
Query: 479 NDLNKRVQDLSA 490
DL+ ++ +L A
Sbjct: 1058 TDLSDQIAELQA 1069
Score = 31.6 bits (70), Expect = 2.0
Identities = 38/169 (22%), Positives = 72/169 (42%), Gaps = 23/169 (13%)
Query: 147 QSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNS 206
Q +E + R ++ K K E T+ + +++ E K+A L ++ +E + +
Sbjct: 1774 QKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAA 1833
Query: 207 QKQMKLLQKK-QSQLVQEKDHLRGEH---SKAVLARSKLESLCRELQRHNRSLKEEGVQR 262
KQ++ +KK + L+Q D R +A A ++L+ L R+L+ EE QR
Sbjct: 1834 CKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEE-----AEEEAQR 1888
Query: 263 AREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKK 311
A K +Q ++E E + +E L +L++
Sbjct: 1889 ANASRRK--------------LQRELEDATETADAMNREVSSLKNKLRR 1923
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 73.6 bits (179), Expect = 4e-13
Identities = 101/469 (21%), Positives = 191/469 (40%), Gaps = 55/469 (11%)
Query: 56 EGAQARTAQSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRT 115
E +A A +LSR+LE+I + + G AQ E + +AE
Sbjct: 1124 EEIEAERASRAKAEKQRSDLSRELEEIS-----ERLEEAGGATSAQIEMNKKREAE---- 1174
Query: 116 YVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGK-EITL 174
+ + E + + + + + + + E D R Q+ +K K K EI
Sbjct: 1175 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDD 1234
Query: 175 LMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKA 234
L + T+S + L +C+ + L E + +++ Q+ + L ++ L+ E +
Sbjct: 1235 LASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQ---QRLINDLTAQRARLQTESGEY 1291
Query: 235 VLARSKLESLCRELQRHNRSLKE--EGVQRAREEEEKRKEVTSH-FQVTLNDIQLQMEQH 291
+ ++L +L R ++ + E ++R EEE K K +H Q + +D L EQ+
Sbjct: 1292 SRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQY 1351
Query: 292 NER--------------NSKLRQ-----------ENMELAERLKKLIEQYELREEHIDKV 326
E NS++ Q EL E KKL ++ + EEH++ V
Sbjct: 1352 EEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAV 1411
Query: 327 FKHKDLQQQLVDAKLQ-QAQEMLKEAE---------ERHQREKDFLLKEAVESQRMCELM 376
K + +LQ + ++++ + E ++ QR D +L E Q+ E
Sbjct: 1412 -NAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEW--KQKCEETH 1468
Query: 377 KQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRW 436
+ E K+ +L TE F+ +N +S + T K+E + + ++I L ++ R
Sbjct: 1469 AELEASQKESRSLSTELFK-IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRI 1527
Query: 437 ESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRV 485
K ++ +EK+ LE + ++ E +Q E N + V
Sbjct: 1528 HELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1576
Score = 65.9 bits (159), Expect = 9e-11
Identities = 79/351 (22%), Positives = 152/351 (43%), Gaps = 41/351 (11%)
Query: 162 KKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLV 221
+ K K L +E+ L +T+ L T E+K AL + + + L++ + + ++ L K + +L
Sbjct: 976 ENKVKNLTEEMAGLDETIAKL-TKEKK--ALQEAHQQTLDDLQAEEDKVNTLTKAKIKLE 1032
Query: 222 QEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTL 281
Q+ D L G + R LE R+L+ + L +E ++++ E + +
Sbjct: 1033 QQVDDLEGSLEQEKKIRMDLERAKRKLEG-DLKLAQESTMDIENDKQQLDEKLKKKEFEM 1091
Query: 282 NDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKL 341
+ +Q ++E +L+++ EL R+++L E+ E K K Q+ + +L
Sbjct: 1092 SGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEK----QRSDLSREL 1147
Query: 342 QQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTL 401
++ E L+EA + + K E Q+M ++ L T + E TL
Sbjct: 1148 EEISERLEEAGGATSAQIEMNKKREAEFQKM-----------RRDLEEATLQHEATAATL 1196
Query: 402 SKS-SEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGL 460
K ++ ++++ + + +KLEKE + EM E +E +
Sbjct: 1197 RKKHADSVAELGEQIDNLQRVKQKLEKEKS--------------EMKMEIDDLASNMETV 1242
Query: 461 QVKIQRLEKLCRALQ-------TERNDLNKRVQDLSAGGQGSLTDSGPERR 504
LEK+CRAL+ T+ + + + DL+A T+SG R
Sbjct: 1243 SKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSR 1293
Score = 62.4 bits (150), Expect = 1e-09
Identities = 71/319 (22%), Positives = 148/319 (46%), Gaps = 62/319 (19%)
Query: 186 EEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLC 245
E+++A + +++ + EE ++ + K L++K L+QEK+ L+ + + + E C
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERC 909
Query: 246 RELQRHNRSLK---EEGVQRAREEEEKRKEVT----------SHFQVTLNDIQLQMEQHN 292
+L + L+ +E +RA +EEE E+T S + ++D++L +
Sbjct: 910 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL---- 965
Query: 293 ERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAE 352
+K+ +E ++K L E+ +E I K+ K K K +
Sbjct: 966 ---AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK------------------KALQ 1004
Query: 353 ERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFK 412
E HQ+ D L E + + + + L+QQ+ ++ + +L + ++ +
Sbjct: 1005 EAHQQTLDDLQAE----EDKVNTLTKAKIKLEQQV-------DDLEGSLEQEKKI----R 1049
Query: 413 QEMEKMTKKIK---KLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEK 469
++E+ +K++ KL +E+TM E+ + L E ++K + E+ GLQ KI+ +
Sbjct: 1050 MDLERAKRKLEGDLKLAQESTM---DIENDKQQLDEKLKKK---EFEMSGLQSKIEDEQA 1103
Query: 470 LCRALQTERNDLNKRVQDL 488
L LQ + +L R+++L
Sbjct: 1104 LGMQLQKKIKELQARIEEL 1122
Score = 57.8 bits (138), Expect = 3e-08
Identities = 87/369 (23%), Positives = 160/369 (43%), Gaps = 53/369 (14%)
Query: 162 KKKAKGLGKEITLLM----QTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQ 217
+K+++ L E+ + ++L+ L T + + L ++ ++L E+ K++ L+K +
Sbjct: 1475 QKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIK 1534
Query: 218 SQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEE-----KRK- 271
Q+ QEK L+ +A + E +Q +K E ++ E++E KR
Sbjct: 1535 KQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNH 1594
Query: 272 -EVTSHFQVTL-------ND-IQLQMEQH---NERNSKLRQENMELAERLKKLIEQYELR 319
+ Q TL ND I+L+ + NE +L N AE L+ +
Sbjct: 1595 IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAIL 1654
Query: 320 EE---HIDKVFK-HKDLQQQLV----DAKLQQAQ-EMLKEAEERHQREKDFLLKEAVESQ 370
++ H+D + +DL++QL A L QA+ E L+ E+ +R + +E +++
Sbjct: 1655 KDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDAS 1714
Query: 371 RMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETT 430
+L+ Q T L + T+K + + +S+ QE +K KK +
Sbjct: 1715 ERVQLLHTQNTSL-----INTKK--KLETDISQIQGEMEDIIQEARNAEEKAKKAITDAA 1767
Query: 431 MYRS--RWESSNKALLEMAE---EKTVRDKE----------LEGLQVKIQRLEKLCRALQ 475
M + E A LE + E+TV+D + L+G + +IQ+LE R L+
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELE 1827
Query: 476 TERNDLNKR 484
E KR
Sbjct: 1828 GEVESEQKR 1836
Score = 57.0 bits (136), Expect = 4e-08
Identities = 62/322 (19%), Positives = 143/322 (44%), Gaps = 25/322 (7%)
Query: 177 QTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVL 236
QTL+ L E+K+ L K +L ++ + + ++ +K + L + K L G+ A
Sbjct: 1009 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQE 1068
Query: 237 ARSKLESLCRELQR--HNRSLKEEGVQRAREEEE----KRKEVTSHFQVTLNDIQLQMEQ 290
+ +E+ ++L + + G+Q E+E+ + ++ Q + +++ ++E
Sbjct: 1069 STMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEA 1128
Query: 291 HNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKE 350
+K ++ +L+ L+++ E R E + + +A+ Q+ + L+E
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISE----RLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1184
Query: 351 AEERHQREKDFLLKEAVES-----------QRMCELMKQQETHLKQQ---LALYTEKFEE 396
A +H+ L K+ +S QR+ + ++++++ +K + LA E +
Sbjct: 1185 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSK 1244
Query: 397 FQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKE 456
+ L K E++ ++ ++L + T R+R ++ + +EK +
Sbjct: 1245 AKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQ 1304
Query: 457 L-EGLQVKIQRLEKLCRALQTE 477
L G Q Q++E+L R L+ E
Sbjct: 1305 LSRGKQAFTQQIEELKRQLEEE 1326
Score = 49.7 bits (117), Expect = 7e-06
Identities = 65/303 (21%), Positives = 138/303 (45%), Gaps = 38/303 (12%)
Query: 141 NTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALC------K 194
NT+ I + ++ D R QE K +++ ++ + N L E+L A +
Sbjct: 1649 NTQAILKDTQLHLDDALRSQEDLK-----EQLAMVERRANLLQAEIEELRATLEQTERSR 1703
Query: 195 KYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRS 254
K AE +E ++ ++++LL + + L+ K L + S+ + ++E + +E +
Sbjct: 1704 KIAE--QELLDASERVQLLHTQNTSLINTKKKLETDISQI---QGEMEDIIQEARNAEEK 1758
Query: 255 LKEEGVQRAREEEEKRKE--VTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERL--- 309
K+ A EE +KE ++H + +M+++ E+ K Q ++ AE+L
Sbjct: 1759 AKKAITDAAMMAEELKKEQDTSAHLE--------RMKKNLEQTVKDLQHRLDEAEQLALK 1810
Query: 310 --KKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKD----FLL 363
KK I++ E R ++ + + Q++ V+A + K E +Q E+D L
Sbjct: 1811 GGKKQIQKLEARVRELEGEVESE--QKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRL 1868
Query: 364 KEAVES-QRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKI 422
++ V+ Q + K+Q ++Q + KF Q+ L ++ E + ++ K+ K
Sbjct: 1869 QDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKS 1928
Query: 423 KKL 425
+++
Sbjct: 1929 REV 1931
Score = 46.6 bits (109), Expect = 6e-05
Identities = 66/338 (19%), Positives = 142/338 (42%), Gaps = 45/338 (13%)
Query: 187 EKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCR 246
E+L KK A+ L++ +++ ++ + K + L + K L+ E ++ + + C
Sbjct: 1388 EELEEAKKKLAQRLQD---AEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACA 1444
Query: 247 ELQRHNRSLKE---EGVQRARE---EEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQ 300
L + R+ + E Q+ E E E ++ + L I+ E+ ++ L++
Sbjct: 1445 ALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKR 1504
Query: 301 ENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKD 360
EN L + + L EQ + I ++ K K + V+ + + Q L+EAE + E+
Sbjct: 1505 ENKNLQQEISDLTEQIAEGGKRIHELEKIK----KQVEQEKSELQAALEEAEASLEHEEG 1560
Query: 361 FLLKEAVE----SQRMCELMKQQETHLKQQLALYTEKFEEFQNTLS---KSSEVFTTFKQ 413
+L+ +E + + +++ + Q + E Q+TL +S K+
Sbjct: 1561 KILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1620
Query: 414 EME---------------------KMTKKIKKLEKETTMYRS---RWESSNKALLEMAEE 449
+ME + + + + K+T ++ R + K L M E
Sbjct: 1621 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVER 1680
Query: 450 KT-VRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQ 486
+ + E+E L+ +++ E+ + + E D ++RVQ
Sbjct: 1681 RANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1718
Score = 43.1 bits (100), Expect = 6e-04
Identities = 47/196 (23%), Positives = 88/196 (44%), Gaps = 39/196 (19%)
Query: 197 AELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSK-----LESLCRELQRH 251
AE L++ +++ ++ ++K Q V++ H E + L K LE+ REL+
Sbjct: 1770 AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGE 1829
Query: 252 NRSLKE---EGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAER 308
S ++ E V+ R+ E K KE+T + +R + LR + +L ++
Sbjct: 1830 VESEQKRNVEAVKGLRKHERKVKELT-------------YQTEEDRKNILRLQ--DLVDK 1874
Query: 309 LKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVE 368
L+ ++ Y+ + E ++ Q + +K ++ Q L+EAEER + E
Sbjct: 1875 LQAKVKSYKRQAEEAEE-------QSNVNLSKFRRIQHELEEAEER---------ADIAE 1918
Query: 369 SQRMCELMKQQETHLK 384
SQ +K +E H K
Sbjct: 1919 SQVNKLRVKSREVHTK 1934
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 73.6 bits (179), Expect = 4e-13
Identities = 96/467 (20%), Positives = 188/467 (40%), Gaps = 51/467 (10%)
Query: 56 EGAQARTAQSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRT 115
E +A A +LSR+LE+I + + G AQ E + +AE
Sbjct: 1124 EEIEAERASRAKAEKQRSDLSRELEEIS-----ERLEEAGGATSAQIEMNKKREAE---- 1174
Query: 116 YVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKG-LGKEITL 174
+ + E + + + + + + + + E D R Q+ +K K L EI
Sbjct: 1175 FQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEIND 1234
Query: 175 LMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKA 234
L + T+S + +C+ + L E + +++ Q+ ++L +K L E +
Sbjct: 1235 LASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQ---QRLINELSAQKARLHTESGEF 1291
Query: 235 VLARSKLESLCRELQRHNRSLKE--EGVQRAREEEEKRKEVTSH-FQVTLNDIQLQMEQH 291
+ +++ +L R ++ + E ++R EEE K K +H Q +D L EQ+
Sbjct: 1292 SRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQY 1351
Query: 292 NERNSK-------LRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAK---- 340
E + + N E+A+ K R E +++ K L Q+L DA+
Sbjct: 1352 EEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEA--KKKLAQRLQDAEEHVE 1409
Query: 341 -LQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQN 399
+ L++ ++R Q E + L+ + S C + +++ + + LA + +K+EE Q
Sbjct: 1410 AVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQA 1469
Query: 400 TL--------SKSSEVFT-------------TFKQEMEKMTKKIKKLEKETTMYRSRWES 438
L S S+E+F T K+E + + ++I L ++
Sbjct: 1470 ELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHE 1529
Query: 439 SNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRV 485
K ++ EK+ LE + ++ E +Q E N + +
Sbjct: 1530 LEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576
Score = 65.5 bits (158), Expect = 1e-10
Identities = 66/334 (19%), Positives = 151/334 (45%), Gaps = 23/334 (6%)
Query: 162 KKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLV 221
+ K K L +E+ L +T+ L T E+K AL + + + L++ + + ++ L K +++L
Sbjct: 976 ENKVKNLTEEMAGLDETIAKL-TKEKK--ALQEAHQQTLDDLQMEEDKVNTLTKAKTKLE 1032
Query: 222 QEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLK------EEGVQRAREEEEKRKEVTS 275
Q+ D L G + + LC +L+R R L+ +E ++++ E
Sbjct: 1033 QQVDDLEGSLEQE-------KKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLK 1085
Query: 276 HFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQ 335
+ ++++Q ++E +L+++ EL R+++L E+ E K K Q+
Sbjct: 1086 KKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEK----QRS 1141
Query: 336 LVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFE 395
+ +L++ E L+EA + + K E Q+M +++ + A +K
Sbjct: 1142 DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHA 1201
Query: 396 EFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDK 455
+ ++++ E + ++ +K+ K+ +L+ E S E+ +KA + +
Sbjct: 1202 D---SVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLED 1258
Query: 456 ELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLS 489
+L ++ K + ++L L ++ L+ + S
Sbjct: 1259 QLSEIKTKEEEQQRLINELSAQKARLHTESGEFS 1292
Score = 47.0 bits (110), Expect = 4e-05
Identities = 57/302 (18%), Positives = 135/302 (44%), Gaps = 36/302 (11%)
Query: 141 NTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALC------K 194
NT+ I + ++ D R Q+ K +++ ++ + N + E+L A +
Sbjct: 1649 NTQGILKDTQLHLDDAIRGQDDLK-----EQLAMVERRANLMQAEVEELRASLERTERGR 1703
Query: 195 KYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRS 254
K AE +E ++ ++++LL + + L+ K L + S+ + ++E + +E +
Sbjct: 1704 KMAE--QELLDASERVQLLHTQNTSLINTKKKLETDISQI---QGEMEDIVQEARNAEEK 1758
Query: 255 LKEEGVQRAREEEEKRKE---------VTSHFQVTLNDIQLQMEQHNERNSKLRQENMEL 305
K+ A EE +KE + + + T+ D+QL++++ + K ++ ++
Sbjct: 1759 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQK 1818
Query: 306 AE-RLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLK 364
E R+++L + E ++H + K ++ V Q +E R+ L+
Sbjct: 1819 LEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEE---------DRKNILRLQ 1869
Query: 365 EAVES-QRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIK 423
+ V+ Q + K+Q ++Q + KF + Q+ L ++ E + ++ K+ K +
Sbjct: 1870 DLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSR 1929
Query: 424 KL 425
++
Sbjct: 1930 EV 1931
Score = 46.2 bits (108), Expect = 8e-05
Identities = 71/354 (20%), Positives = 152/354 (42%), Gaps = 64/354 (18%)
Query: 186 EEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQE---KDHLRGEHSKAVLARSKLE 242
+EKLA L + + + K++++++S + + + +H + K++
Sbjct: 782 DEKLAQLITRTQAICRGFLMRVEFRKMMERRESIFCIQYNIRAFMNVKHWPWMKLYFKIK 841
Query: 243 SLCR--ELQRHNRSLKEEGVQRAREE----EEKRKEVTSHFQVTL----NDIQLQMEQH- 291
L + E ++ ++KEE ++ +EE E KRKE+ VTL ND+QLQ++
Sbjct: 842 PLLKSAETEKEMANMKEE-FEKTKEELAKTEAKRKELEEKM-VTLMQEKNDLQLQVQAEA 899
Query: 292 ------NERNSKLRQENMELAERLKKLIEQYELREE-HIDKVFKHKDLQQQLVDAK--LQ 342
ER +L + ++L ++K++ E+ E EE + + K + L+ + + K +
Sbjct: 900 DALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID 959
Query: 343 QAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLS 402
+ L + E KE ++ + + ++ L + +A T++ + Q
Sbjct: 960 DLELTLAKVE-----------KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1008
Query: 403 KSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKAL-------------LEMAEE 449
++ + + ++ +TK KLE++ E K L++A+E
Sbjct: 1009 QTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQE 1068
Query: 450 KTV---------------RDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDL 488
T+ ++ E+ LQ KI+ + L LQ + +L R+++L
Sbjct: 1069 STMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEEL 1122
Score = 40.8 bits (94), Expect = 0.003
Identities = 89/511 (17%), Positives = 184/511 (36%), Gaps = 41/511 (8%)
Query: 32 ERPSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLEDILSTYCVDNN 91
E +Q A G S Q K + A EEL RQLE+ +
Sbjct: 1276 ELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAH 1335
Query: 92 QGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGE-KEPSKGDPNTEEIRQSDE 150
+ E+ ++++ + R + V K + TEE+ ++ +
Sbjct: 1336 ALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKK 1395
Query: 151 -----VGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALC-----------K 194
+ D + K L K L + L E+ A C K
Sbjct: 1396 KLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDK 1455
Query: 195 KYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRS 254
AE +++ +Q +++ QK+ L E ++ + +++ LE+L RE N++
Sbjct: 1456 VLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESL---DHLETLKRE----NKN 1508
Query: 255 LKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQME-QHNERNSKLRQENMELAERLKKLI 313
L++E + E K + L ++ Q++ + +E + L + L K++
Sbjct: 1509 LQQEISDLTEQIAEGGKHIHE-----LEKVKKQLDHEKSELQTSLEEAEASLEHEEGKIL 1563
Query: 314 E-QYELRE--EHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQ 370
Q EL + ID+ KD + + + E ++ + R ++ L+ + +
Sbjct: 1564 RIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKME 1623
Query: 371 RMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETT 430
M+ Q H +Q A Q L + + + + +++ +E+
Sbjct: 1624 GDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRAN 1683
Query: 431 MYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLSA 490
+ ++ E +L + + ++EL ++Q L +L + L + +
Sbjct: 1684 LMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQI-- 1741
Query: 491 GGQGSLTDSGPERRPEGPGAQAPSSPRVTEA 521
QG + D E R A+ + +T+A
Sbjct: 1742 --QGEMEDIVQEAR----NAEEKAKKAITDA 1766
Score = 38.5 bits (88), Expect = 0.016
Identities = 47/266 (17%), Positives = 115/266 (43%), Gaps = 23/266 (8%)
Query: 132 EKEPSKGDPNTEEIRQSDEVGDRDHRRPQEK-----KKAKGLGKEITLLMQTLNTLSTPE 186
E+ + EE+R S E +R + +++ ++ + L + T L+ T L T
Sbjct: 1679 ERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDI 1738
Query: 187 EKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCR 246
++ + ++++E RN++++ K + + +E + + + +E +
Sbjct: 1739 SQIQG---EMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1795
Query: 247 ELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELA 306
+LQ ++ ++ +++ +K + + +++ ++E + N + + +
Sbjct: 1796 DLQLRLDEAEQLALKGGKKQIQK-------LEARVRELESEVESEQKHNVEAVKGLRKHE 1848
Query: 307 ERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQE--------MLKEAEERHQRE 358
R+K+L Q E ++I ++ D Q V A +QA+E + K + +H+ E
Sbjct: 1849 RRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELE 1908
Query: 359 KDFLLKEAVESQRMCELMKQQETHLK 384
+ + ESQ +K +E H K
Sbjct: 1909 EAKERADIAESQVNKLRVKSREVHTK 1934
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 73.2 bits (178), Expect = 6e-13
Identities = 85/392 (21%), Positives = 170/392 (43%), Gaps = 55/392 (14%)
Query: 136 SKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITL----LMQTLNTLSTPEEKLAA 191
SKG+ E +++ + + ++ +E K + L + + L+ LN L +EK
Sbjct: 815 SKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEK 874
Query: 192 LCKKYAE---------LLEEH--RNSQKQMKLLQ---KKQSQLVQEKDHLRGEHSKAVLA 237
KK +E ++ H + + +Q +LQ ++Q Q++Q++ GE
Sbjct: 875 QLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDT--- 931
Query: 238 RSKLESLCRELQRHNRSLKEEGVQRAREEEEK----------RKEVTSHFQVTLNDIQLQ 287
++KLE +L++ + +E ++ R+ EEK +++ T ++++
Sbjct: 932 QTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIE 991
Query: 288 MEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEM 347
M+Q+ E SK+ +E M L E + H+ ++ D+ +L++
Sbjct: 992 MDQYKEELSKMEKEIMHLK-------RDGENKAMHLSQL----DMILDQTKTELEKKTNA 1040
Query: 348 LKEAEE-RHQREKDFLLKEAVESQRMCEL-MKQQETHLKQQLALYTEKFEEFQNTLSKSS 405
+KE E+ +H E + L EA++ + + E ++ LK L E + Q
Sbjct: 1041 VKELEKLQHSTETE--LTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE 1098
Query: 406 EVFTTFKQ--------EMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKEL 457
E +TT K +ME KK + LE + + WE +A + T+R+
Sbjct: 1099 EKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRG 1158
Query: 458 EGLQVKIQRLEKLCRALQTERNDLNKRVQDLS 489
E ++ KI +LE + E + NK+++ L+
Sbjct: 1159 E-MEQKIIKLEGTLEKSELELKECNKQIESLN 1189
Score = 70.1 bits (170), Expect = 5e-12
Identities = 87/402 (21%), Positives = 183/402 (45%), Gaps = 53/402 (13%)
Query: 113 SRTYVARNGEPEPTPVVNGEKEPSK--GDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGK 170
S++ + N E + + + E EP K G E ++ ++ + ++ G+ +
Sbjct: 586 SQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEE 645
Query: 171 EITLLMQTLNTLSTPEEKLAALCKKYA----ELLEEHRNSQKQMKLLQKKQSQLVQEKDH 226
T L+Q S + +A ++ ELLE+ NS K + KK SQL+
Sbjct: 646 LRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLT---- 701
Query: 227 LRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQL 286
L + + ++A S + + EL+ Q E+ EK + + ++ I L
Sbjct: 702 LEKQLEEKIVAYSSIAAKNAELE-----------QELMEKNEKIRSLETNINTEHEKICL 750
Query: 287 QMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKD-----LQQQLV--DA 339
E K ++ ++E + ++K IE+ E + E D+ FK ++ LQQ ++
Sbjct: 751 AFE-------KAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQH 803
Query: 340 KLQQAQEMLKEAEERHQRE---KDFLLKEAVESQRMCELMKQQETH-----LKQQLALYT 391
L+ +L E++ ++E KD LK A+++Q E +K ++ K++L L+
Sbjct: 804 HLESLDRLLTESKGEMKKENMKKDEALK-ALQNQVSEETIKVRQLDSALEICKEELVLHL 862
Query: 392 EKF----EEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMA 447
+ E+F+ L K SE ++E++ +++ ++ + + + +M
Sbjct: 863 NQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQ----QML 918
Query: 448 EEKTVRDKELEGLQVKIQR-LEKLCRALQTERNDLNKRVQDL 488
+++T+R+ ELE Q K+++ + KL + LQ +R ++++ +
Sbjct: 919 QQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKM 960
Score = 55.1 bits (131), Expect = 2e-07
Identities = 76/359 (21%), Positives = 162/359 (45%), Gaps = 55/359 (15%)
Query: 160 QEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQ-- 217
Q K++ + KEI L + + +L + + LE+ N+ K+++ LQ
Sbjct: 994 QYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTET 1053
Query: 218 --SQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTS 275
++ +Q+++ L E A +L+S R+LQ R + ++ E+ K++T+
Sbjct: 1054 ELTEALQKREVLETELQNA---HGELKSTLRQLQEL-RDVLQKAQLSLEEKYTTIKDLTA 1109
Query: 276 HFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEH----------IDK 325
+ +I+ + ++ E + L++ N EL +R ++ EH ++
Sbjct: 1110 ELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEG 1169
Query: 326 VFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFL----------LKEAVE--SQRMC 373
+ +L+ + + +++ + L+ A+E+ REK+F+ LK+ +E QRM
Sbjct: 1170 TLEKSELELKECNKQIESLNDKLQNAKEQ-LREKEFIMLQNEQEISQLKKEIERTQQRMK 1228
Query: 374 EL---MKQQETH----------LKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTK 420
E+ MK+QE + L Q+L L E+ + L+++ ++E+E+++
Sbjct: 1229 EMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSS 1288
Query: 421 KI---KKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEG-LQVKIQRLEKLCRALQ 475
++ K+L KE ++ L E VR+ LE +Q +I++L +L+
Sbjct: 1289 ELEDMKQLSKEK-------DAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLK 1340
Score = 47.0 bits (110), Expect = 4e-05
Identities = 51/235 (21%), Positives = 94/235 (40%), Gaps = 17/235 (7%)
Query: 238 RSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSK 297
R K+ S + + +SL+E+ + + R++ I ++ Q + S
Sbjct: 217 RDKMFSSSAPVDQEIKSLREK-LNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSM 275
Query: 298 LRQENMELAER--LKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERH 355
L + A L++ I E DKV + + KL+Q+Q+M+ E E+
Sbjct: 276 LESAQQQAASVPILEEQIINLEAEVSAQDKVLRE-------AENKLEQSQKMVIEKEQSL 328
Query: 356 QREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEM 415
Q K+ +K V+ + K+ E + L E + FQ K +E + E
Sbjct: 329 QESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEE 388
Query: 416 EKMTKKIKKLEKETT-------MYRSRWESSNKALLEMAEEKTVRDKELEGLQVK 463
E + + + EKE +Y+S E + L ++ EE ++L + VK
Sbjct: 389 EILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVK 443
Score = 45.8 bits (107), Expect = 1e-04
Identities = 56/278 (20%), Positives = 123/278 (44%), Gaps = 21/278 (7%)
Query: 215 KKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVT 274
K Q+Q K + + E + V +L + +++ N LK R T
Sbjct: 621 KDQNQHTMNKQYEK-ERQRLVTGIEELRTKLIQIEAENSDLKVNMAHR-----------T 668
Query: 275 SHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVF-KHKDLQ 333
S FQ+ IQ ++ + +SKL E + +L L +Q E + + K+ +L+
Sbjct: 669 SQFQL----IQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELE 724
Query: 334 QQLVDAKLQQAQEMLKEAEERHQRE-KDFLLKEAVESQRMCELMKQQETHLKQQLALYTE 392
Q+L++ K ++ + + H++ F + + ++ E+ KQ E L+ QL +
Sbjct: 725 QELME-KNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIE-RLEAQLEKKDQ 782
Query: 393 KFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTV 452
+F+E + T+S + + +E + + + + + E + + + KAL E+T+
Sbjct: 783 QFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETI 842
Query: 453 RDKELE-GLQVKIQRLEKLCRALQTERNDLNKRVQDLS 489
+ ++L+ L++ + L L+ + K+++ S
Sbjct: 843 KVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKS 880
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 72.8 bits (177), Expect = 8e-13
Identities = 75/355 (21%), Positives = 175/355 (49%), Gaps = 29/355 (8%)
Query: 132 EKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITL-----LMQTLNTLSTPE 186
+++ K E+IR+ +E R EK++ +E+ + + + E
Sbjct: 378 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 437
Query: 187 EKLAALCKKYAEL-----LEEHRNSQKQMKLLQKKQSQ---LVQEKDHLRGEHSKAVLAR 238
EK+ L +K E EE R +++++ +K+Q Q + ++++ +R + K R
Sbjct: 438 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI---R 494
Query: 239 SKLESLCRELQR-HNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSK 297
+ E + R+ ++ H + E +R +EE R+E Q +I Q E+ +E+ K
Sbjct: 495 EQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQ---EEIWRQKEKIHEQEEK 551
Query: 298 LRQENMELAERLKKLIEQYELREEHIDKVFKHKD-LQQQLVDAKLQQAQEMLKEAEERHQ 356
+R++ ++ + +K+ +Q E E +KV++ ++ +++Q + K+++ +E ++E EE Q
Sbjct: 552 IRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQ--EEKIREQEEKIREQEEMTQ 609
Query: 357 REKDFLLKEAVESQRMCEL---MKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQ 413
+++ K + ++MCE M++QE +++Q E+ ++ + K E ++
Sbjct: 610 EQEE---KMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 666
Query: 414 EMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLE 468
+ EKM ++ +K+ ++ + + E + +M E++ ++ E +Q + LE
Sbjct: 667 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 71.2 bits (173), Expect = 2e-12
Identities = 74/386 (19%), Positives = 178/386 (46%), Gaps = 44/386 (11%)
Query: 132 EKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEIT------------------ 173
E E S+ N +E+++ E + Q + +A LGKE+
Sbjct: 295 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 354
Query: 174 LLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKK---QSQLVQEKDHLRGE 230
L Q + EEK+ +K E E+ R +++++ ++K Q +++ EK+
Sbjct: 355 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 414
Query: 231 HSKAVLARS----KLESLCRELQRHNRSLKEE--GVQRAREEEEKRKEVTSHFQVTLNDI 284
+ + + + E + E + R L+E+ ++ RE+EEKR+E +
Sbjct: 415 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE---------EEK 465
Query: 285 QLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQA 344
+ E+ E+ +K+ ++ ++ E+ +K+ EQ E +K+ + + ++++ K Q+
Sbjct: 466 IREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREE---EKRQEQ 522
Query: 345 QEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHL---KQQLALYTEKFEEFQNTL 401
+EM ++ E+ ++E+ + KE + Q E +++QE + ++++ EK E + +
Sbjct: 523 EEMWRQEEKIREQEEIWRQKEKIHEQE--EKIRKQEEKMWRQEEKMHDQEEKIREQEEKV 580
Query: 402 SKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQ 461
+ E ++++ + +KI++ E+ T + + + E E+ +++++ +
Sbjct: 581 WRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQE 640
Query: 462 VKIQRLEKLCRALQTERNDLNKRVQD 487
KI+ EK R + + + + +Q+
Sbjct: 641 EKIREQEKKIREQEEKIREQEEMMQE 666
Score = 67.4 bits (163), Expect = 3e-11
Identities = 76/306 (24%), Positives = 155/306 (50%), Gaps = 36/306 (11%)
Query: 175 LMQTLNTLSTPEEK----LAALCKKYAEL-LEEHRNSQKQMKLLQKKQSQLVQEKDHLRG 229
L Q L+ ++T ++K + L K+ L LE +RN+ +L ++K ++L ++ +
Sbjct: 238 LEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEEL-KEKNAKLQEKLQLVES 296
Query: 230 EHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQME 289
E S+ L ++ L R+L+R L ++ +Q E + KE+ S +Q Q+E
Sbjct: 297 EKSEIQL---NVKELKRKLERAKLLLPQQQLQA--EADHLGKELQS----VSAKLQAQVE 347
Query: 290 QHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLK 349
+ NE ++L Q+ E R ++ I+++E + +Q+Q + K+++ +E ++
Sbjct: 348 E-NELWNRLNQQQEEKMWRQEEKIQEWE------------EKIQEQ--EEKIREQEEKIR 392
Query: 350 EAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSE--- 406
E EE+ +R+++ + ++ + +R E+M ++E +++Q + EK E+ + K E
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 452
Query: 407 --VFTTFKQEMEKMTKKIKKLEKETTMYRSRWE-SSNKALLEMAEEKTVRDKELEGLQVK 463
+QE EK+ ++ K+ E+E M+R + + + EEK R +E Q K
Sbjct: 453 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEK 512
Query: 464 IQRLEK 469
I+ EK
Sbjct: 513 IREEEK 518
Score = 62.8 bits (151), Expect = 8e-10
Identities = 67/348 (19%), Positives = 164/348 (47%), Gaps = 38/348 (10%)
Query: 147 QSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNS 206
+ +E+ +R +++ +EK + ++ + + + EEK+ +K E E+ R
Sbjct: 347 EENELWNRLNQQQEEK-----MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 401
Query: 207 QKQM----KLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQR 262
++ M + +++++ + ++++ +R + K+ L ++ + ++E
Sbjct: 402 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE---E 458
Query: 263 AREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEH 322
R+EEEK +E Q + Q E+ E+ K+R++ ++ + +K+ EQ ++REE
Sbjct: 459 KRQEEEKIREQEKR-QEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEE 517
Query: 323 I-----------DKVFKHKDLQQQLVDAKLQQAQEMLKEAEER--HQREKDFLLKEAVES 369
+K+ + +++ +Q K+ + +E +++ EE+ Q EK +E +
Sbjct: 518 KRQEQEEMWRQEEKIREQEEIWRQ--KEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIRE 575
Query: 370 Q-----RMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKK 424
Q R E +++QE +++Q E+ E Q K E ++ EKM ++ +K
Sbjct: 576 QEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEK 635
Query: 425 LEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKI-QRLEKLC 471
+ ++ R + K + E E+ +++ ++ + K+ ++ EK+C
Sbjct: 636 MRRQEEKIREQ----EKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 679
Score = 62.0 bits (149), Expect = 1e-09
Identities = 58/312 (18%), Positives = 150/312 (48%), Gaps = 43/312 (13%)
Query: 143 EEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEE 202
E++ + +++ +++ +R +E+K + +E+ A + ++ ++ E+
Sbjct: 445 EKMHEQEKIREQEEKRQEEEK---------------IREQEKRQEQEAKMWRQEEKIREQ 489
Query: 203 HRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCR---------ELQRHNR 253
++Q + + + Q + + E++ +R E R + E + R E+ R
Sbjct: 490 EEKIREQEEKMWR-QEEKIHEQEKIREEEK-----RQEQEEMWRQEEKIREQEEIWRQKE 543
Query: 254 SLKEEGVQRAREEEEK--RKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKK 311
+ E+ ++ R++EEK R+E H Q I+ Q E+ + K+R++ ++ E+ +K
Sbjct: 544 KIHEQE-EKIRKQEEKMWRQEEKMHDQE--EKIREQEEKVWRQEEKIREQEEKIREQEEK 600
Query: 312 LIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQR 371
+ EQ E+ +E +K+ + ++ K+ + +E ++E EE+ +R+++ + ++ + +
Sbjct: 601 IREQEEMTQEQEEKMGEQEE--------KMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE 652
Query: 372 MCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTM 431
E +++QE +++Q E+ E+ K E +++ EKM ++ +L ++
Sbjct: 653 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 712
Query: 432 YRSRWESSNKAL 443
+ E A+
Sbjct: 713 MQEHQEHLEAAI 724
Score = 32.3 bits (72), Expect = 1.1
Identities = 33/146 (22%), Positives = 69/146 (47%), Gaps = 13/146 (8%)
Query: 350 EAEERHQREKDFLLKEAVESQ-RMCELMKQQETHLKQQLALYTEKFE------EFQNTLS 402
E E++ + L+ +E+Q ++ Q+T L Q+ALY + E ++ +S
Sbjct: 169 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTEL--QMALYYSQHAVKQLEGEARDLIS 226
Query: 403 KSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQV 462
+ + + F E+E+ + +K+ Y AL T+ D+EL+
Sbjct: 227 RLHDSWK-FAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 285
Query: 463 KIQRLEKLCRALQTERNDLNKRVQDL 488
K+Q EKL + +++E++++ V++L
Sbjct: 286 KLQ--EKL-QLVESEKSEIQLNVKEL 308
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 72.8 bits (177), Expect = 8e-13
Identities = 81/365 (22%), Positives = 158/365 (43%), Gaps = 32/365 (8%)
Query: 128 VVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEE 187
V +G+++ K D ++ + ++ + + + L KE L ++ L E+
Sbjct: 2510 VEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTV--ELEQ 2567
Query: 188 KLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRE 247
K+ L K A L Q +++LQ L E + + + V +K+ + E
Sbjct: 2568 KIQVLQSKNASL-------QDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETE 2620
Query: 248 LQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAE 307
LQR + ++ + E ++ + Q+ L +I+ +Q E L EN EL +
Sbjct: 2621 LQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKE----LTLENSELKK 2676
Query: 308 RLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREK-DFLLKEA 366
L + H D+V K +++++ + +L+ L EAE++HQ D +
Sbjct: 2677 SLDCM---------HKDQVEKEGKVREEIAEYQLR-----LHEAEKKHQALLLDTNKQYE 2722
Query: 367 VESQRMCELMKQQETHLKQQ---LALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIK 423
VE Q E + +E L Q + L EE N+L ++++ K+ K +
Sbjct: 2723 VEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVN 2782
Query: 424 KLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNK 483
+L+KE + + + K+ ++ EEK + KEL LQ Q +K + T+ ++L
Sbjct: 2783 QLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQA-AQEKQKTGTVMDTKVDELTT 2841
Query: 484 RVQDL 488
+++L
Sbjct: 2842 EIKEL 2846
Score = 66.2 bits (160), Expect = 7e-11
Identities = 93/432 (21%), Positives = 182/432 (42%), Gaps = 73/432 (16%)
Query: 120 NGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTL 179
+GE E TP + K D N+ S D + Q ++ + E+ L +Q
Sbjct: 247 SGEQEVTPS-RSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKIN-ELELRLQG- 303
Query: 180 NTLSTPEEKLAALCKKYAELLEEHRNSQKQM----KLLQKKQSQLVQEKDHLRGEHSKAV 235
E+++ K+ EL + ++ ++ K+L K + +LV+ +K
Sbjct: 304 -----HEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYT 358
Query: 236 LARSKLESLCREL--QRHNR-----SLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQM 288
KL+ L +L QR N SL+++ ++ +E +E+ FQ TL+ +QM
Sbjct: 359 ALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQ-TLDQECIQM 417
Query: 289 E------------QHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQL 336
+ HN ++L + + ++L+ +E+++ + ++ F+ +++
Sbjct: 418 KARLTQELQQAKNMHNVLQAEL-DKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENE 476
Query: 337 VDAKLQQAQE---MLKEAEERHQREKDFL------LKEAV-ESQRMCELMKQQETHLKQQ 386
+ +++ ++ +LK E+ RE L +K+ + +SQ E MK + T +
Sbjct: 477 LRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETM 536
Query: 387 LALYTEKFEEFQNTLSK----------------SSEVFTTFKQEMEKMTKKIKKLEKETT 430
L EK + +N+L+ S ++ + +E++ K+ K EKE+
Sbjct: 537 LRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESK 596
Query: 431 MYRSRWESSNKALLEMAEEKTV--------------RDKELEGLQVKIQRLEKLCRALQT 476
S E K E+ EEKT+ + E E LQ KI LE + Q
Sbjct: 597 ALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQI 656
Query: 477 ERNDLNKRVQDL 488
+ ++ N+RV+ L
Sbjct: 657 KSHEYNERVRTL 668
Score = 64.7 bits (156), Expect = 2e-10
Identities = 67/329 (20%), Positives = 149/329 (45%), Gaps = 38/329 (11%)
Query: 187 EKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCR 246
EKL ++ L ++ N ++++++ ++ Q ++ L E+SKA ++E+L
Sbjct: 2140 EKLKERERENDSLKDKVENLERELQMSEENQELVI-----LDAENSKA-----EVETLKT 2189
Query: 247 ELQRHNRSLK--EEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENME 304
+++ RSLK E + R E+E + Q L+++ + + Q ++
Sbjct: 2190 QIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQ 2249
Query: 305 LAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDA-------------KLQQAQEMLKEA 351
+ E K +E + + + +++ Q+++ A +L+ + E L+
Sbjct: 2250 IKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRAR 2309
Query: 352 EERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTF 411
E ++++ +L++ ES+ +L+K + +L+++L + E S T
Sbjct: 2310 LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETL 2369
Query: 412 KQEMEKMTKKIKKLEKETTMYRSRWES------------SNKALLEMAEEKTVRDKELEG 459
K ++E MT+ ++ LE + RS E+ S ++ + E +++KE E
Sbjct: 2370 KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEK 2429
Query: 460 LQVKIQRLEKLCRALQTERNDLNKRVQDL 488
+Q+K ++ LQT+ +LN+RV L
Sbjct: 2430 VQMK-EKSSTAMEMLQTQLKELNERVAAL 2457
Score = 59.3 bits (142), Expect = 9e-09
Identities = 80/373 (21%), Positives = 156/373 (41%), Gaps = 42/373 (11%)
Query: 124 EPTPVVNGEKEPSKGDPNTEEIRQS--DEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNT 181
E VV E+ +G+ +T + + D++ ++ + QE + + E +Q
Sbjct: 1951 EELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQS---ECLHCIQVAEA 2007
Query: 182 -LSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSK 240
+ E L L +ELL++ + Q++++ L+K L K L E+ A L + K
Sbjct: 2008 EVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCEL--ENQIAQLNKEK 2065
Query: 241 LESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQ 300
E L +E + L E ++ + + + L Q E H R
Sbjct: 2066 -ELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRG---- 2120
Query: 301 ENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKD 360
E+L+ IE E ++ HI + K ++ + + K++ + L+ +EE ++
Sbjct: 2121 -----IEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEE----NQE 2171
Query: 361 FLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTK 420
++ +A S+ E +K Q EE +L T + E E +TK
Sbjct: 2172 LVILDAENSKAEVETLKTQ--------------IEEMARSLKVFELDLVTLRSEKENLTK 2217
Query: 421 KIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKE-----LEGLQVKIQRLEKLCRALQ 475
+I++ + + + + SS K+LLE E+ ++ KE +E LQ +++ L + AL
Sbjct: 2218 QIQEKQGQLSEL-DKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALC 2276
Query: 476 TERNDLNKRVQDL 488
++ + Q L
Sbjct: 2277 GDQEIMKATEQSL 2289
Score = 58.9 bits (141), Expect = 1e-08
Identities = 72/341 (21%), Positives = 140/341 (41%), Gaps = 51/341 (14%)
Query: 199 LLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGE---HSKAVLARSKLESLCRELQRHNRSL 255
L +++ N QK + L+++ S + E++ LRGE SK A +L +E + S
Sbjct: 1935 LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESH 1994
Query: 256 KEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQ----------ENMEL 305
+ E + + E + KE T Q +D+ ++ KL+ EL
Sbjct: 1995 QSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCEL 2054
Query: 306 AERLKKLIEQYE------------LREEHIDKVFKHKDLQQQLVDA-------------- 339
++ +L ++ E L E +K+ K L+ LV+
Sbjct: 2055 ENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEV 2114
Query: 340 -KLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQ 398
+L++ E L+ E ++++ + ++ E +R + +K + +L+++L + E E
Sbjct: 2115 HQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVI 2174
Query: 399 NTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDK--- 455
S T K ++E+M + +K E + RS E+ K + E + + DK
Sbjct: 2175 LDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLS 2234
Query: 456 -------ELEGLQVKIQRLEKLC-RALQTERNDLNKRVQDL 488
E E +++I+ K LQ + +LN+ V L
Sbjct: 2235 SFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAAL 2275
Score = 54.7 bits (130), Expect = 2e-07
Identities = 68/329 (20%), Positives = 146/329 (44%), Gaps = 40/329 (12%)
Query: 173 TLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHS 232
+ + +T +S +E +A AE L N +K+++LL K E L+ +
Sbjct: 876 SFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNH 935
Query: 233 KAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHN 292
LE +ELQ + +L E +KE++S + +I+ ++ Q N
Sbjct: 936 L-------LEDSLKELQLLSETLSLE-----------KKEMSSIISLNKREIE-ELTQEN 976
Query: 293 ----ERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEML 348
E N+ L QE M L ++ + + RE+ I ++ ++ ++ + ++
Sbjct: 977 GTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAY 1036
Query: 349 KEAEERHQ--REKDFLLKEAV-ESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSS 405
++ ++++ +EK+ L+ + E +CE K + LK+ A ++ +EF L+ +
Sbjct: 1037 EDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA---KEHQEFLTKLAFAE 1093
Query: 406 EVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESS--NKALLEMAEEKTVRDKELEGL--- 460
E E+E + + ++ E S+ E+ + ++ + EE+ KE+ L
Sbjct: 1094 ERNQNLMLELETVQQALRS-EMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQE 1152
Query: 461 ---QVKIQRLEKLCRALQTE--RNDLNKR 484
+K+ + + C+ L++E RN + +R
Sbjct: 1153 NEQLMKVMKTKHECQNLESEPIRNSVKER 1181
Score = 53.1 bits (126), Expect = 6e-07
Identities = 81/411 (19%), Positives = 173/411 (42%), Gaps = 33/411 (8%)
Query: 108 EDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKG 167
E EK++ ++ + + + V E + + G E++ Q + + R Q+ ++
Sbjct: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
Query: 168 LGKEITLLMQTLNTLS-TPEE-----KLAALCKKYAELLEEHRNSQKQMKLLQ-KKQSQL 220
+ Q + T TP + K L +KY + +EE + + ++K LQ KK SQ
Sbjct: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQT 196
Query: 221 VQE-----KDHLRGEHSKAVLARSKLESLCRELQRHNRS-LKEEGVQRAREEEEKRKEVT 274
+ + +D R + S +V + + ++ R+ ++ + E++
Sbjct: 197 LPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSR 256
Query: 275 SHFQVTLNDIQLQMEQHNERN---SKLRQENMELAERLKKLIEQYELREEHI-DKVFKHK 330
S Q+ D ++ +L+ +N EL ++ +L + + E+ + +V K +
Sbjct: 257 STLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQ 316
Query: 331 DLQQQLVDAKLQQAQ----------EMLKEAEERHQREKDFLLKEAVESQRMCELMKQQE 380
+LQ QL AK++ + E+++ + Q + E + +L Q++
Sbjct: 317 ELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQ 376
Query: 381 THLKQQLAL---YTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWE 437
+ +L EK +EFQ LS+ F T QE +M +L +E ++
Sbjct: 377 NAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMK---ARLTQELQQAKNMHN 433
Query: 438 SSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDL 488
L ++ K + LE + K+ R E+ +A Q + N+L + ++++
Sbjct: 434 VLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEM 484
Score = 50.8 bits (120), Expect = 3e-06
Identities = 60/272 (22%), Positives = 128/272 (47%), Gaps = 27/272 (9%)
Query: 240 KLESLCRELQRHNRSLKEEGVQRAREEEE--KRKEVTSHFQVTLNDIQLQMEQHNERNSK 297
K+ESL E++ + L + VQ + E + +++ + +D+ ++E + + +
Sbjct: 1796 KVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQE 1855
Query: 298 LRQENMELAERLKKLIEQY---ELREEHIDKVFKHKDL-QQQLVDAKLQQAQEMLKEAEE 353
L Q +E +E L +E + RE+ D V K D +++ +D + + ++ ++A
Sbjct: 1856 LLQR-VETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASI 1914
Query: 354 RHQR---EKDFLLKEAVESQRMCELMKQQETH------LKQQLALYTEKFEEFQNTLSKS 404
H+ E D E V+++++C L K E L+++L++ T + + + L
Sbjct: 1915 EHEALYLEADL---EVVQTEKLC-LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTM 1970
Query: 405 SEVFTTFKQEMEKMTKKIKKLEKETT-------MYRSRWESSNKALLEMAEEKTVRDKEL 457
S+ T Q EKM +K ++LE + + + + + L ++ + + K+
Sbjct: 1971 SKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDK 2030
Query: 458 EGLQVKIQRLEKLCRALQTERNDLNKRVQDLS 489
LQ K+Q LEK +AL + +L ++ L+
Sbjct: 2031 THLQEKLQSLEKDSQALSLTKCELENQIAQLN 2062
Score = 50.8 bits (120), Expect = 3e-06
Identities = 64/363 (17%), Positives = 149/363 (41%), Gaps = 38/363 (10%)
Query: 150 EVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEE----KLAALCKKYAELLEEHRN 205
++ + +H K + + L +E+ + + E ++ L K + + R
Sbjct: 2323 QLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRG 2382
Query: 206 SQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRARE 265
+ + ++ ++ L E + S+ + S E++ +E ++ +KE+
Sbjct: 2383 LELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEM 2442
Query: 266 EEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIE----------- 314
+ + KE+ ND + + +S++ +E A+ L+ L E
Sbjct: 2443 LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSS 2502
Query: 315 -------------QYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDF 361
+ E ++E I ++ Q+QLV +KL Q E E + +E++
Sbjct: 2503 VNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV-SKLSQV-----EGEHQLWKEQNL 2556
Query: 362 LLKE-AVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTK 420
L+ VE ++ ++++ + L+ L + ++ +N L + +F +++ KMT
Sbjct: 2557 ELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTA 2616
Query: 421 KIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERND 480
K +L++E + + + E++ EK EL+ L +I+ + + L E ++
Sbjct: 2617 KETELQRE---MHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSE 2673
Query: 481 LNK 483
L K
Sbjct: 2674 LKK 2676
Score = 48.9 bits (115), Expect = 1e-05
Identities = 93/419 (22%), Positives = 167/419 (39%), Gaps = 80/419 (19%)
Query: 143 EEIRQSDEVGDRDHRRPQEKKKAKGLG----KEITLLMQTLNTLSTPEEKLAALCKKYAE 198
+E++ ++ + + QE KK+ L KE+ LL +TL+ + +L K+ E
Sbjct: 911 KELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIE 970
Query: 199 LLEEHRNS---------QKQMKLLQKKQS-----------------QLVQEK-------- 224
L + + Q++M L+QK +S Q QEK
Sbjct: 971 ELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCE 1030
Query: 225 ------DHLRGEHSKAVLARSKLE-------SLCRELQRHNRSLKEEGVQRARE------ 265
+ L ++ A SKLE SLC + LKE + +E
Sbjct: 1031 ETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLA 1090
Query: 266 -EEEKRKEVTSHFQVTLNDIQLQMEQHNERNSK-----LRQENMELAE---RLKKLIEQY 316
EE+ + + + ++ +M N+ NSK L+QE M L E +++K +
Sbjct: 1091 FAEERNQNLMLELETVQQALRSEMTD-NQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL 1149
Query: 317 ELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAE-ERHQ----REKDFLLKEAVESQR 371
E + KV K K Q L ++ + +KE E ER+Q + D +KE
Sbjct: 1150 LQENEQLMKVMKTKHECQNLESEPIRNS---VKERESERNQCNFKPQMDLEVKEISLDSY 1206
Query: 372 MCELMKQQETHLKQQLALYTEKFEE--FQNTLSK-SSEVFTTFKQEMEKMTKKIKKLEKE 428
+L++ + ++L L + E+ Q+ L ++ T+ Q+M+ +++I L+
Sbjct: 1207 NAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQ--SQEISGLKDC 1264
Query: 429 TTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQD 487
++ S L + L+ K+ LEK+C LQ E+ +L + D
Sbjct: 1265 EIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELND 1323
Score = 45.1 bits (105), Expect = 2e-04
Identities = 48/208 (23%), Positives = 94/208 (45%), Gaps = 24/208 (11%)
Query: 161 EKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAEL-LEEHRNSQKQMKLLQKKQSQ 219
E+ KAK +E T+L ++ E L K A LE+ R+ + LL+K++
Sbjct: 524 EEMKAKNTSQE-TMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQD--LLKKREHH 580
Query: 220 LVQEKDHLRG--EHSKAVLARSKLESLCRELQRHNRSL-------KEEGVQRAREEEEKR 270
+ Q D L + SKA+L+ +L+ E + ++L E+ + + E+E
Sbjct: 581 IEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENL 640
Query: 271 KEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHK 330
+ +H + L Q++ ++NER L + L+ ++ L + + ++
Sbjct: 641 QSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVE------ 694
Query: 331 DLQQQLVDAKLQQAQEMLKEAEERHQRE 358
Q+L +LQQ E ++++HQ+E
Sbjct: 695 --TQKLAYMELQQKAEF---SDQKHQKE 717
Score = 37.4 bits (85), Expect = 0.036
Identities = 70/351 (19%), Positives = 142/351 (40%), Gaps = 56/351 (15%)
Query: 144 EIRQSDEVGDRDHRRPQEKK--KAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLE 201
E++Q E D+ H++ E K L ++ L L LS ++ + Y +L
Sbjct: 702 ELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSN---EIMDKDRCYQDL-- 756
Query: 202 EHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQR---HNRSLKEE 258
H + LL+ K + LV +DH R ++LA + ++ S+ E
Sbjct: 757 -HAEYESLRDLLKSKDASLVTNEDHQR-----SLLAFDQQPAMHHSFANIIGEQGSMPSE 810
Query: 259 GVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYEL 318
+ E ++ K ++ Q ++ ++ +E + NS L+++ EL + +K IE
Sbjct: 811 RSECRLEADQSPKN-SAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQ-IKGEIE---- 864
Query: 319 REEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQ 378
E L +AE+ HQ F+ A SQR+ +L +
Sbjct: 865 ---------------------------ENLMKAEQMHQ---SFV---AETSQRISKLQED 891
Query: 379 QETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWES 438
H + +A E + L ++ T + E++++ K LE + E+
Sbjct: 892 TSAH-QNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSET 950
Query: 439 SNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLS 489
+ EM+ ++ +E+E L + L+++ +L E+ +L ++ + +
Sbjct: 951 LSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
Score = 35.0 bits (79), Expect = 0.18
Identities = 31/133 (23%), Positives = 64/133 (48%), Gaps = 17/133 (12%)
Query: 311 KLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQ 370
+ +++ + E +DK+ K K +Q +D+ L+ A + K+ E + E L +E
Sbjct: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDS-LEAALQKQKQKVENEKTEGTNLKRENQRLM 73
Query: 371 RMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQ-EMEKMTKKIKKLEKET 429
+CE +++ + + +L + K S+V F++ ++ K+I+KLE+E
Sbjct: 74 EICESLEKTKQKISHELQV-------------KESQV--NFQEGQLNSGKKQIEKLEQEL 118
Query: 430 TMYRSRWESSNKA 442
+S E S +A
Sbjct: 119 KRCKSELERSQQA 131
Score = 31.2 bits (69), Expect = 2.5
Identities = 18/76 (23%), Positives = 45/76 (59%), Gaps = 4/76 (5%)
Query: 413 QEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKI--QRLEKL 470
Q+++++ ++ KL+KE + + +S AL + +++ V +++ EG +K QRL ++
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQK--QKQKVENEKTEGTNLKRENQRLMEI 75
Query: 471 CRALQTERNDLNKRVQ 486
C +L+ + ++ +Q
Sbjct: 76 CESLEKTKQKISHELQ 91
Score = 30.4 bits (67), Expect = 4.3
Identities = 74/411 (18%), Positives = 148/411 (36%), Gaps = 90/411 (21%)
Query: 149 DEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQK 208
D + R+H Q K KE L+ L K+Y EL EE
Sbjct: 572 DLLKKREHHIEQLNDKLSKTEKESKALLSALELKK----------KEYEELKEEKTLFSC 621
Query: 209 QMKLLQKKQSQLVQEKDHLRGE--HSKAVLARSKLES-------LCRELQRHNRSLKEEG 259
+K +Q+ EK++L+ + H + L +++S E+ R N S++
Sbjct: 622 WKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRN 681
Query: 260 VQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMEL-AERLKKLIEQYEL 318
+ + + E ++ ++Q + E ++++ K ENM L +L +E E
Sbjct: 682 LHNVLDSKSVEVETQ---KLAYMELQQKAEFSDQKHQK-EIENMCLKTSQLTGQVEDLEH 737
Query: 319 REEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAE------ERHQR--------------- 357
+ + + KD Q + A+ + +++LK + E HQR
Sbjct: 738 KLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSF 797
Query: 358 -------------------------EKDFLLKEAVES---------------QRMCELMK 377
+ +L+ V+S Q+ CE +
Sbjct: 798 ANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELV 857
Query: 378 QQETHLKQQLALYTEKFEEF----QNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYR 433
Q + +++ L + + F +SK E + + + + ++ EKE +
Sbjct: 858 QIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLN 917
Query: 434 SRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKR 484
+ E+ + E+ + + + L+ LQ+ + L L + + LNKR
Sbjct: 918 DKVETEQAEIQELKKSNHLLEDSLKELQLLSETL-SLEKKEMSSIISLNKR 967
Score = 30.4 bits (67), Expect = 4.3
Identities = 30/110 (27%), Positives = 54/110 (49%), Gaps = 10/110 (9%)
Query: 221 VQEKDHLRGEHSKA-VLARSKLESLC----RELQRHNRSLKEEGVQRAREEEEKRKEVTS 275
+QE++ R E A +LESLC + L++ ++ +G+ + +E +E + ++S
Sbjct: 1531 LQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSS 1590
Query: 276 HFQVTLNDIQLQMEQHNER-NSKLRQENMELAERL---KKLIEQYELREE 321
Q L+ ++ Q NE+ KL +E+ +L KK EQ L E
Sbjct: 1591 ERQ-ELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELE 1639
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 72.4 bits (176), Expect = 1e-12
Identities = 110/539 (20%), Positives = 216/539 (40%), Gaps = 60/539 (11%)
Query: 4 QDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTA 63
+ K+ + + + + E A+ER ++ A E A + E +A+
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019
Query: 64 QSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEP 123
++ LR+ +E+ S + + Q E+ A + ++ E +T E
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQA---EEKAHAFAVQQKEQELQQTL---QQEQ 2073
Query: 124 EPTPVVNGEKEPSK-GDPNTEEIR-QSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNT 181
+ GE E ++ EE R Q++ + R+ +E ++ K +E Q
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA---QARAQ 2130
Query: 182 LSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKL 241
EKL +K AE R +Q L QK+ + EK E + A+ +
Sbjct: 2131 AQAAAEKL----RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186
Query: 242 ESLCRELQR----HNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSK 297
E LQ H ++L +E +QR + E + S + L +++QME+ ++ ++
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR 2246
Query: 298 LRQEN---------------MELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQ 342
+ EN E AE++K++ E+ + + + L ++ + +
Sbjct: 2247 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2306
Query: 343 QAQEMLKEAEE------RHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFE- 395
A++MLKE + R + E + L ++ +Q +++ + + QQLA T+ F+
Sbjct: 2307 LAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR 2366
Query: 396 ----EFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKAL--LEMAEE 449
E Q L S+E K + +M++ + E++ +R + E + L E+A +
Sbjct: 2367 TLEAERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425
Query: 450 KTV------------RDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLSAGGQGSL 496
+ V D + E L+ I LE+ LQ E L + +++ Q L
Sbjct: 2426 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2484
Score = 69.3 bits (168), Expect = 8e-12
Identities = 98/460 (21%), Positives = 192/460 (41%), Gaps = 43/460 (9%)
Query: 28 EGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLEDILSTYC 87
E A E+ Q A EA +QA R+ + Q R + R+ + ++Q + +
Sbjct: 1366 EAALEKQRQLA---EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422
Query: 88 VDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQ 147
Q E A+ AE AE+SR + + E++ + + +R
Sbjct: 1423 QQLRQSSEAEIQAKARQAEA--AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1480
Query: 148 SDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQ 207
E + R+ QE+ A+ L +++ Q E +LA+ K AE E Q
Sbjct: 1481 RAEEAEAQKRQAQEE--AERLRRQVQDESQRKRQA---EVELASRVKAEAEAARE---KQ 1532
Query: 208 KQMKLLQKKQSQLVQEKDHLR-GEHSKAVLARSKLESLCR----ELQRHNRSLKEEGVQR 262
+ ++ L++ + Q + + LR E +A + LE+ R ELQ S E+ Q
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 263 AREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEH 322
R +E+ V Q+ + ER ++ + E E ++ +E+++L+
Sbjct: 1593 ERSLQEEHVAVA------------QLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640
Query: 323 I-------DKVFKHKDLQQQLVDAKLQQAQEMLK---EAEERHQREKDFLLKEAVESQRM 372
++V + K L Q + + ++A+ + +AEE+ R+++ +E + +++
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Query: 373 CELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMY 432
E QQ +Q+L + E+ + E ++E T+K ++LE E
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760
Query: 433 RSRWE--SSNKALLEMAEEKTVRDKELEGLQVKIQRLEKL 470
R+ E ++KA E E ++ +K + L+ + R +L
Sbjct: 1761 RAEMEVLLASKARAE-EESRSTSEKSKQRLEAEAGRFREL 1799
Score = 62.4 bits (150), Expect = 1e-09
Identities = 106/528 (20%), Positives = 213/528 (40%), Gaps = 75/528 (14%)
Query: 4 QDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTA 63
Q ++ A + + + ++ E AQ R A A + +A R+ + QA
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158
Query: 64 QSGAL-------RDVSEELSRQ---LEDILSTYCVD----NNQGGPGEDGAQGEPAEPED 109
Q A + +E+ RQ +E L+T + ++Q ++ Q AE +
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 110 AEKSRTYVARNG-----------------EPEPTPVVNGEKEPSKG--DPNTEEIRQSDE 150
A + R+ V E E ++ +K+ ++ E+++Q E
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278
Query: 151 VGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAAL-----CKKYAELLEEHRN 205
R QE + + L +E L Q +EK+ A+ K AELL++ +
Sbjct: 2279 EAARLSVAAQEAARLRQLAEE-DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337
Query: 206 -SQKQMKLLQKKQSQLVQE--------KDHLRGEHSKAVLARSKLESLCRELQRHNRSLK 256
+Q+Q + LQ+ + Q+ Q+ + L E + + ++ E L + +R+
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2397
Query: 257 --EEGVQRAREEEEK------RKEVTSHFQVTL-NDIQLQMEQHNERNSKLRQENMELAE 307
EE QR R++ E+ R E+ + +VTL +++Q +Q + +LR+ EL
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457
Query: 308 RLKKLIEQ---YELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREK----- 359
+KL ++ +L+ E + V Q+QL+ Q L E + QRE+
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTV-----QQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2512
Query: 360 -----DFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQE 414
E ++Q++ E ++Q+ ++Q+ EE + ++ E ++E
Sbjct: 2513 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572
Query: 415 MEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQV 462
++++ ++ ++ E+ R + L E +E+ QV
Sbjct: 2573 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620
Score = 55.5 bits (132), Expect = 1e-07
Identities = 114/525 (21%), Positives = 209/525 (39%), Gaps = 82/525 (15%)
Query: 20 PGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQ--ARTAQSGALRDVSEELS- 76
P E E AQ Q E EG G A E + A S A + EL
Sbjct: 1010 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1069
Query: 77 -----RQLEDILSTYCVDNNQGGPGEDGAQGEP----AEPEDAEKSRTYVARNGEPEPTP 127
Q+ + + Y G QG A E ++++ A E E T
Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1129
Query: 128 V------VNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEK---------KKAKGLGKEI 172
E + D +E+R + EVG+R +R E+ + A+ L +
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189
Query: 173 TLLMQTLNTLSTPEEKLAALCKKYAEL-------LEEHRNSQKQMKLLQKKQSQLVQEKD 225
+L QT + E+L + Y E L++ R Q+Q++ + SQ V+E+
Sbjct: 1190 AVLAQT-DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ- 1247
Query: 226 HLRGEHSKAVLAR-----SKLESLCRELQRHNRSLKEEGVQRAREEEE--------KRKE 272
LR E +A+L K+E R +++ ++K+ +Q + + K+ +
Sbjct: 1248 -LRQE--QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1304
Query: 273 VTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELRE-------EHIDK 325
V S + + + ++E + Q ++E L+++ E+ L E E + +
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364
Query: 326 VFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQ 385
V + Q+QL +A Q + +EA+E QR + +E V + +QQ+ +++
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSIQE 1420
Query: 386 QLALYTEKFEEFQNTLSKSSEVFTTFK-QEMEKMTKKIKKLEKETTMYRSRWESSNKALL 444
+L L +SSE K ++ E + ++E+E + R + E++ +
Sbjct: 1421 EL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER--- 1466
Query: 445 EMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLS 489
++ + EL+ L+ + + E R Q E L ++VQD S
Sbjct: 1467 ----QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Score = 33.9 bits (76), Expect = 0.39
Identities = 35/162 (21%), Positives = 68/162 (41%), Gaps = 21/162 (12%)
Query: 215 KKQSQLVQEKDHLRGEHSKAVLARSKLES-LCRELQRHNRSLKEEGV---------QRAR 264
+++ QL E + L E + ++ + ++E+ LC E +L + V QRA
Sbjct: 379 EREKQLRSEFERL--ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAG 436
Query: 265 EEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELR----- 319
E E + S ++ ND+Q + + + ++ + L ERL + +Y LR
Sbjct: 437 EVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGV 496
Query: 320 ----EEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQR 357
+ + + +L D+ L+ Q++L EE R
Sbjct: 497 AAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 538
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 72.4 bits (176), Expect = 1e-12
Identities = 110/539 (20%), Positives = 216/539 (40%), Gaps = 60/539 (11%)
Query: 4 QDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTA 63
+ K+ + + + + E A+ER ++ A E A + E +A+
Sbjct: 1964 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2023
Query: 64 QSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEP 123
++ LR+ +E+ S + + Q E+ A + ++ E +T E
Sbjct: 2024 EARRLRERAEQESARQLQLAQEAAQKRLQA---EEKAHAFAVQQKEQELQQTL---QQEQ 2077
Query: 124 EPTPVVNGEKEPSK-GDPNTEEIR-QSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNT 181
+ GE E ++ EE R Q++ + R+ +E ++ K +E Q
Sbjct: 2078 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA---QARAQ 2134
Query: 182 LSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKL 241
EKL +K AE R +Q L QK+ + EK E + A+ +
Sbjct: 2135 AQAAAEKL----RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2190
Query: 242 ESLCRELQR----HNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSK 297
E LQ H ++L +E +QR + E + S + L +++QME+ ++ ++
Sbjct: 2191 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR 2250
Query: 298 LRQEN---------------MELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQ 342
+ EN E AE++K++ E+ + + + L ++ + +
Sbjct: 2251 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2310
Query: 343 QAQEMLKEAEE------RHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFE- 395
A++MLKE + R + E + L ++ +Q +++ + + QQLA T+ F+
Sbjct: 2311 LAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR 2370
Query: 396 ----EFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKAL--LEMAEE 449
E Q L S+E K + +M++ + E++ +R + E + L E+A +
Sbjct: 2371 TLEAERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2429
Query: 450 KTV------------RDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLSAGGQGSL 496
+ V D + E L+ I LE+ LQ E L + +++ Q L
Sbjct: 2430 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2488
Score = 69.3 bits (168), Expect = 8e-12
Identities = 98/460 (21%), Positives = 192/460 (41%), Gaps = 43/460 (9%)
Query: 28 EGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLEDILSTYC 87
E A E+ Q A EA +QA R+ + Q R + R+ + ++Q + +
Sbjct: 1370 EAALEKQRQLA---EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1426
Query: 88 VDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQ 147
Q E A+ AE AE+SR + + E++ + + +R
Sbjct: 1427 QQLRQSSEAEIQAKARQAEA--AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1484
Query: 148 SDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQ 207
E + R+ QE+ A+ L +++ Q E +LA+ K AE E Q
Sbjct: 1485 RAEEAEAQKRQAQEE--AERLRRQVQDESQRKRQA---EVELASRVKAEAEAARE---KQ 1536
Query: 208 KQMKLLQKKQSQLVQEKDHLR-GEHSKAVLARSKLESLCR----ELQRHNRSLKEEGVQR 262
+ ++ L++ + Q + + LR E +A + LE+ R ELQ S E+ Q
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1596
Query: 263 AREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEH 322
R +E+ V Q+ + ER ++ + E E ++ +E+++L+
Sbjct: 1597 ERSLQEEHVAVA------------QLREEAERRAQQQAEAERAREEAERELERWQLKANE 1644
Query: 323 I-------DKVFKHKDLQQQLVDAKLQQAQEMLK---EAEERHQREKDFLLKEAVESQRM 372
++V + K L Q + + ++A+ + +AEE+ R+++ +E + +++
Sbjct: 1645 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1704
Query: 373 CELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMY 432
E QQ +Q+L + E+ + E ++E T+K ++LE E
Sbjct: 1705 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1764
Query: 433 RSRWE--SSNKALLEMAEEKTVRDKELEGLQVKIQRLEKL 470
R+ E ++KA E E ++ +K + L+ + R +L
Sbjct: 1765 RAEMEVLLASKARAE-EESRSTSEKSKQRLEAEAGRFREL 1803
Score = 62.4 bits (150), Expect = 1e-09
Identities = 106/528 (20%), Positives = 213/528 (40%), Gaps = 75/528 (14%)
Query: 4 QDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTA 63
Q ++ A + + + ++ E AQ R A A + +A R+ + QA
Sbjct: 2103 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2162
Query: 64 QSGAL-------RDVSEELSRQ---LEDILSTYCVD----NNQGGPGEDGAQGEPAEPED 109
Q A + +E+ RQ +E L+T + ++Q ++ Q AE +
Sbjct: 2163 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2222
Query: 110 AEKSRTYVARNG-----------------EPEPTPVVNGEKEPSKG--DPNTEEIRQSDE 150
A + R+ V E E ++ +K+ ++ E+++Q E
Sbjct: 2223 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2282
Query: 151 VGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAAL-----CKKYAELLEEHRN 205
R QE + + L +E L Q +EK+ A+ K AELL++ +
Sbjct: 2283 EAARLSVAAQEAARLRQLAEE-DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2341
Query: 206 -SQKQMKLLQKKQSQLVQE--------KDHLRGEHSKAVLARSKLESLCRELQRHNRSLK 256
+Q+Q + LQ+ + Q+ Q+ + L E + + ++ E L + +R+
Sbjct: 2342 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2401
Query: 257 --EEGVQRAREEEEK------RKEVTSHFQVTL-NDIQLQMEQHNERNSKLRQENMELAE 307
EE QR R++ E+ R E+ + +VTL +++Q +Q + +LR+ EL
Sbjct: 2402 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2461
Query: 308 RLKKLIEQ---YELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREK----- 359
+KL ++ +L+ E + V Q+QL+ Q L E + QRE+
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTV-----QQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2516
Query: 360 -----DFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQE 414
E ++Q++ E ++Q+ ++Q+ EE + ++ E ++E
Sbjct: 2517 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2576
Query: 415 MEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQV 462
++++ ++ ++ E+ R + L E +E+ QV
Sbjct: 2577 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2624
Score = 55.5 bits (132), Expect = 1e-07
Identities = 114/525 (21%), Positives = 209/525 (39%), Gaps = 82/525 (15%)
Query: 20 PGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQ--ARTAQSGALRDVSEELS- 76
P E E AQ Q E EG G A E + A S A + EL
Sbjct: 1014 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1073
Query: 77 -----RQLEDILSTYCVDNNQGGPGEDGAQGEP----AEPEDAEKSRTYVARNGEPEPTP 127
Q+ + + Y G QG A E ++++ A E E T
Sbjct: 1074 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1133
Query: 128 V------VNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEK---------KKAKGLGKEI 172
E + D +E+R + EVG+R +R E+ + A+ L +
Sbjct: 1134 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1193
Query: 173 TLLMQTLNTLSTPEEKLAALCKKYAEL-------LEEHRNSQKQMKLLQKKQSQLVQEKD 225
+L QT + E+L + Y E L++ R Q+Q++ + SQ V+E+
Sbjct: 1194 AVLAQT-DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ- 1251
Query: 226 HLRGEHSKAVLAR-----SKLESLCRELQRHNRSLKEEGVQRAREEEE--------KRKE 272
LR E +A+L K+E R +++ ++K+ +Q + + K+ +
Sbjct: 1252 -LRQE--QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1308
Query: 273 VTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELRE-------EHIDK 325
V S + + + ++E + Q ++E L+++ E+ L E E + +
Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1368
Query: 326 VFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQ 385
V + Q+QL +A Q + +EA+E QR + +E V + +QQ+ +++
Sbjct: 1369 VEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSIQE 1424
Query: 386 QLALYTEKFEEFQNTLSKSSEVFTTFK-QEMEKMTKKIKKLEKETTMYRSRWESSNKALL 444
+L L +SSE K ++ E + ++E+E + R + E++ +
Sbjct: 1425 EL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER--- 1470
Query: 445 EMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLS 489
++ + EL+ L+ + + E R Q E L ++VQD S
Sbjct: 1471 ----QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1511
Score = 33.9 bits (76), Expect = 0.39
Identities = 35/162 (21%), Positives = 68/162 (41%), Gaps = 21/162 (12%)
Query: 215 KKQSQLVQEKDHLRGEHSKAVLARSKLES-LCRELQRHNRSLKEEGV---------QRAR 264
+++ QL E + L E + ++ + ++E+ LC E +L + V QRA
Sbjct: 383 EREKQLRSEFERL--ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAG 440
Query: 265 EEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELR----- 319
E E + S ++ ND+Q + + + ++ + L ERL + +Y LR
Sbjct: 441 EVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGV 500
Query: 320 ----EEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQR 357
+ + + +L D+ L+ Q++L EE R
Sbjct: 501 AAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 542
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 72.4 bits (176), Expect = 1e-12
Identities = 110/539 (20%), Positives = 216/539 (40%), Gaps = 60/539 (11%)
Query: 4 QDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTA 63
+ K+ + + + + E A+ER ++ A E A + E +A+
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019
Query: 64 QSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEP 123
++ LR+ +E+ S + + Q E+ A + ++ E +T E
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQA---EEKAHAFAVQQKEQELQQTL---QQEQ 2073
Query: 124 EPTPVVNGEKEPSK-GDPNTEEIR-QSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNT 181
+ GE E ++ EE R Q++ + R+ +E ++ K +E Q
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA---QARAQ 2130
Query: 182 LSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKL 241
EKL +K AE R +Q L QK+ + EK E + A+ +
Sbjct: 2131 AQAAAEKL----RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186
Query: 242 ESLCRELQR----HNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSK 297
E LQ H ++L +E +QR + E + S + L +++QME+ ++ ++
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR 2246
Query: 298 LRQEN---------------MELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQ 342
+ EN E AE++K++ E+ + + + L ++ + +
Sbjct: 2247 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2306
Query: 343 QAQEMLKEAEE------RHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFE- 395
A++MLKE + R + E + L ++ +Q +++ + + QQLA T+ F+
Sbjct: 2307 LAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR 2366
Query: 396 ----EFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKAL--LEMAEE 449
E Q L S+E K + +M++ + E++ +R + E + L E+A +
Sbjct: 2367 TLEAERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425
Query: 450 KTV------------RDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLSAGGQGSL 496
+ V D + E L+ I LE+ LQ E L + +++ Q L
Sbjct: 2426 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2484
Score = 69.3 bits (168), Expect = 8e-12
Identities = 98/460 (21%), Positives = 192/460 (41%), Gaps = 43/460 (9%)
Query: 28 EGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLEDILSTYC 87
E A E+ Q A EA +QA R+ + Q R + R+ + ++Q + +
Sbjct: 1366 EAALEKQRQLA---EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422
Query: 88 VDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQ 147
Q E A+ AE AE+SR + + E++ + + +R
Sbjct: 1423 QQLRQSSEAEIQAKARQAEA--AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1480
Query: 148 SDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQ 207
E + R+ QE+ A+ L +++ Q E +LA+ K AE E Q
Sbjct: 1481 RAEEAEAQKRQAQEE--AERLRRQVQDESQRKRQA---EVELASRVKAEAEAARE---KQ 1532
Query: 208 KQMKLLQKKQSQLVQEKDHLR-GEHSKAVLARSKLESLCR----ELQRHNRSLKEEGVQR 262
+ ++ L++ + Q + + LR E +A + LE+ R ELQ S E+ Q
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 263 AREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEH 322
R +E+ V Q+ + ER ++ + E E ++ +E+++L+
Sbjct: 1593 ERSLQEEHVAVA------------QLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640
Query: 323 I-------DKVFKHKDLQQQLVDAKLQQAQEMLK---EAEERHQREKDFLLKEAVESQRM 372
++V + K L Q + + ++A+ + +AEE+ R+++ +E + +++
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Query: 373 CELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMY 432
E QQ +Q+L + E+ + E ++E T+K ++LE E
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760
Query: 433 RSRWE--SSNKALLEMAEEKTVRDKELEGLQVKIQRLEKL 470
R+ E ++KA E E ++ +K + L+ + R +L
Sbjct: 1761 RAEMEVLLASKARAE-EESRSTSEKSKQRLEAEAGRFREL 1799
Score = 62.4 bits (150), Expect = 1e-09
Identities = 106/528 (20%), Positives = 213/528 (40%), Gaps = 75/528 (14%)
Query: 4 QDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTA 63
Q ++ A + + + ++ E AQ R A A + +A R+ + QA
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158
Query: 64 QSGAL-------RDVSEELSRQ---LEDILSTYCVD----NNQGGPGEDGAQGEPAEPED 109
Q A + +E+ RQ +E L+T + ++Q ++ Q AE +
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 110 AEKSRTYVARNG-----------------EPEPTPVVNGEKEPSKG--DPNTEEIRQSDE 150
A + R+ V E E ++ +K+ ++ E+++Q E
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278
Query: 151 VGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAAL-----CKKYAELLEEHRN 205
R QE + + L +E L Q +EK+ A+ K AELL++ +
Sbjct: 2279 EAARLSVAAQEAARLRQLAEE-DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337
Query: 206 -SQKQMKLLQKKQSQLVQE--------KDHLRGEHSKAVLARSKLESLCRELQRHNRSLK 256
+Q+Q + LQ+ + Q+ Q+ + L E + + ++ E L + +R+
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2397
Query: 257 --EEGVQRAREEEEK------RKEVTSHFQVTL-NDIQLQMEQHNERNSKLRQENMELAE 307
EE QR R++ E+ R E+ + +VTL +++Q +Q + +LR+ EL
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457
Query: 308 RLKKLIEQ---YELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREK----- 359
+KL ++ +L+ E + V Q+QL+ Q L E + QRE+
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTV-----QQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2512
Query: 360 -----DFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQE 414
E ++Q++ E ++Q+ ++Q+ EE + ++ E ++E
Sbjct: 2513 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572
Query: 415 MEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQV 462
++++ ++ ++ E+ R + L E +E+ QV
Sbjct: 2573 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620
Score = 55.5 bits (132), Expect = 1e-07
Identities = 114/525 (21%), Positives = 209/525 (39%), Gaps = 82/525 (15%)
Query: 20 PGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQ--ARTAQSGALRDVSEELS- 76
P E E AQ Q E EG G A E + A S A + EL
Sbjct: 1010 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1069
Query: 77 -----RQLEDILSTYCVDNNQGGPGEDGAQGEP----AEPEDAEKSRTYVARNGEPEPTP 127
Q+ + + Y G QG A E ++++ A E E T
Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1129
Query: 128 V------VNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEK---------KKAKGLGKEI 172
E + D +E+R + EVG+R +R E+ + A+ L +
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189
Query: 173 TLLMQTLNTLSTPEEKLAALCKKYAEL-------LEEHRNSQKQMKLLQKKQSQLVQEKD 225
+L QT + E+L + Y E L++ R Q+Q++ + SQ V+E+
Sbjct: 1190 AVLAQT-DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ- 1247
Query: 226 HLRGEHSKAVLAR-----SKLESLCRELQRHNRSLKEEGVQRAREEEE--------KRKE 272
LR E +A+L K+E R +++ ++K+ +Q + + K+ +
Sbjct: 1248 -LRQE--QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1304
Query: 273 VTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELRE-------EHIDK 325
V S + + + ++E + Q ++E L+++ E+ L E E + +
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364
Query: 326 VFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQ 385
V + Q+QL +A Q + +EA+E QR + +E V + +QQ+ +++
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSIQE 1420
Query: 386 QLALYTEKFEEFQNTLSKSSEVFTTFK-QEMEKMTKKIKKLEKETTMYRSRWESSNKALL 444
+L L +SSE K ++ E + ++E+E + R + E++ +
Sbjct: 1421 EL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER--- 1466
Query: 445 EMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLS 489
++ + EL+ L+ + + E R Q E L ++VQD S
Sbjct: 1467 ----QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Score = 33.9 bits (76), Expect = 0.39
Identities = 35/162 (21%), Positives = 68/162 (41%), Gaps = 21/162 (12%)
Query: 215 KKQSQLVQEKDHLRGEHSKAVLARSKLES-LCRELQRHNRSLKEEGV---------QRAR 264
+++ QL E + L E + ++ + ++E+ LC E +L + V QRA
Sbjct: 379 EREKQLRSEFERL--ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAG 436
Query: 265 EEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELR----- 319
E E + S ++ ND+Q + + + ++ + L ERL + +Y LR
Sbjct: 437 EVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGV 496
Query: 320 ----EEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQR 357
+ + + +L D+ L+ Q++L EE R
Sbjct: 497 AAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 538
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 72.4 bits (176), Expect = 1e-12
Identities = 110/539 (20%), Positives = 216/539 (40%), Gaps = 60/539 (11%)
Query: 4 QDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTA 63
+ K+ + + + + E A+ER ++ A E A + E +A+
Sbjct: 1928 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1987
Query: 64 QSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEP 123
++ LR+ +E+ S + + Q E+ A + ++ E +T E
Sbjct: 1988 EARRLRERAEQESARQLQLAQEAAQKRLQA---EEKAHAFAVQQKEQELQQTL---QQEQ 2041
Query: 124 EPTPVVNGEKEPSK-GDPNTEEIR-QSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNT 181
+ GE E ++ EE R Q++ + R+ +E ++ K +E Q
Sbjct: 2042 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA---QARAQ 2098
Query: 182 LSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKL 241
EKL +K AE R +Q L QK+ + EK E + A+ +
Sbjct: 2099 AQAAAEKL----RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2154
Query: 242 ESLCRELQR----HNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSK 297
E LQ H ++L +E +QR + E + S + L +++QME+ ++ ++
Sbjct: 2155 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR 2214
Query: 298 LRQEN---------------MELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQ 342
+ EN E AE++K++ E+ + + + L ++ + +
Sbjct: 2215 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2274
Query: 343 QAQEMLKEAEE------RHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFE- 395
A++MLKE + R + E + L ++ +Q +++ + + QQLA T+ F+
Sbjct: 2275 LAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR 2334
Query: 396 ----EFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKAL--LEMAEE 449
E Q L S+E K + +M++ + E++ +R + E + L E+A +
Sbjct: 2335 TLEAERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2393
Query: 450 KTV------------RDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLSAGGQGSL 496
+ V D + E L+ I LE+ LQ E L + +++ Q L
Sbjct: 2394 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2452
Score = 69.3 bits (168), Expect = 8e-12
Identities = 98/460 (21%), Positives = 192/460 (41%), Gaps = 43/460 (9%)
Query: 28 EGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLEDILSTYC 87
E A E+ Q A EA +QA R+ + Q R + R+ + ++Q + +
Sbjct: 1334 EAALEKQRQLA---EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1390
Query: 88 VDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQ 147
Q E A+ AE AE+SR + + E++ + + +R
Sbjct: 1391 QQLRQSSEAEIQAKARQAEA--AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1448
Query: 148 SDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQ 207
E + R+ QE+ A+ L +++ Q E +LA+ K AE E Q
Sbjct: 1449 RAEEAEAQKRQAQEE--AERLRRQVQDESQRKRQA---EVELASRVKAEAEAARE---KQ 1500
Query: 208 KQMKLLQKKQSQLVQEKDHLR-GEHSKAVLARSKLESLCR----ELQRHNRSLKEEGVQR 262
+ ++ L++ + Q + + LR E +A + LE+ R ELQ S E+ Q
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1560
Query: 263 AREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEH 322
R +E+ V Q+ + ER ++ + E E ++ +E+++L+
Sbjct: 1561 ERSLQEEHVAVA------------QLREEAERRAQQQAEAERAREEAERELERWQLKANE 1608
Query: 323 I-------DKVFKHKDLQQQLVDAKLQQAQEMLK---EAEERHQREKDFLLKEAVESQRM 372
++V + K L Q + + ++A+ + +AEE+ R+++ +E + +++
Sbjct: 1609 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1668
Query: 373 CELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMY 432
E QQ +Q+L + E+ + E ++E T+K ++LE E
Sbjct: 1669 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1728
Query: 433 RSRWE--SSNKALLEMAEEKTVRDKELEGLQVKIQRLEKL 470
R+ E ++KA E E ++ +K + L+ + R +L
Sbjct: 1729 RAEMEVLLASKARAE-EESRSTSEKSKQRLEAEAGRFREL 1767
Score = 62.4 bits (150), Expect = 1e-09
Identities = 106/528 (20%), Positives = 213/528 (40%), Gaps = 75/528 (14%)
Query: 4 QDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTA 63
Q ++ A + + + ++ E AQ R A A + +A R+ + QA
Sbjct: 2067 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2126
Query: 64 QSGAL-------RDVSEELSRQ---LEDILSTYCVD----NNQGGPGEDGAQGEPAEPED 109
Q A + +E+ RQ +E L+T + ++Q ++ Q AE +
Sbjct: 2127 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2186
Query: 110 AEKSRTYVARNG-----------------EPEPTPVVNGEKEPSKG--DPNTEEIRQSDE 150
A + R+ V E E ++ +K+ ++ E+++Q E
Sbjct: 2187 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2246
Query: 151 VGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAAL-----CKKYAELLEEHRN 205
R QE + + L +E L Q +EK+ A+ K AELL++ +
Sbjct: 2247 EAARLSVAAQEAARLRQLAEE-DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2305
Query: 206 -SQKQMKLLQKKQSQLVQE--------KDHLRGEHSKAVLARSKLESLCRELQRHNRSLK 256
+Q+Q + LQ+ + Q+ Q+ + L E + + ++ E L + +R+
Sbjct: 2306 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2365
Query: 257 --EEGVQRAREEEEK------RKEVTSHFQVTL-NDIQLQMEQHNERNSKLRQENMELAE 307
EE QR R++ E+ R E+ + +VTL +++Q +Q + +LR+ EL
Sbjct: 2366 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2425
Query: 308 RLKKLIEQ---YELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREK----- 359
+KL ++ +L+ E + V Q+QL+ Q L E + QRE+
Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTV-----QQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2480
Query: 360 -----DFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQE 414
E ++Q++ E ++Q+ ++Q+ EE + ++ E ++E
Sbjct: 2481 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2540
Query: 415 MEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQV 462
++++ ++ ++ E+ R + L E +E+ QV
Sbjct: 2541 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2588
Score = 55.5 bits (132), Expect = 1e-07
Identities = 114/525 (21%), Positives = 209/525 (39%), Gaps = 82/525 (15%)
Query: 20 PGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQ--ARTAQSGALRDVSEELS- 76
P E E AQ Q E EG G A E + A S A + EL
Sbjct: 978 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1037
Query: 77 -----RQLEDILSTYCVDNNQGGPGEDGAQGEP----AEPEDAEKSRTYVARNGEPEPTP 127
Q+ + + Y G QG A E ++++ A E E T
Sbjct: 1038 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1097
Query: 128 V------VNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEK---------KKAKGLGKEI 172
E + D +E+R + EVG+R +R E+ + A+ L +
Sbjct: 1098 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1157
Query: 173 TLLMQTLNTLSTPEEKLAALCKKYAEL-------LEEHRNSQKQMKLLQKKQSQLVQEKD 225
+L QT + E+L + Y E L++ R Q+Q++ + SQ V+E+
Sbjct: 1158 AVLAQT-DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ- 1215
Query: 226 HLRGEHSKAVLAR-----SKLESLCRELQRHNRSLKEEGVQRAREEEE--------KRKE 272
LR E +A+L K+E R +++ ++K+ +Q + + K+ +
Sbjct: 1216 -LRQE--QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1272
Query: 273 VTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELRE-------EHIDK 325
V S + + + ++E + Q ++E L+++ E+ L E E + +
Sbjct: 1273 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1332
Query: 326 VFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQ 385
V + Q+QL +A Q + +EA+E QR + +E V + +QQ+ +++
Sbjct: 1333 VEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSIQE 1388
Query: 386 QLALYTEKFEEFQNTLSKSSEVFTTFK-QEMEKMTKKIKKLEKETTMYRSRWESSNKALL 444
+L L +SSE K ++ E + ++E+E + R + E++ +
Sbjct: 1389 EL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER--- 1434
Query: 445 EMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLS 489
++ + EL+ L+ + + E R Q E L ++VQD S
Sbjct: 1435 ----QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1475
Score = 33.9 bits (76), Expect = 0.39
Identities = 35/162 (21%), Positives = 68/162 (41%), Gaps = 21/162 (12%)
Query: 215 KKQSQLVQEKDHLRGEHSKAVLARSKLES-LCRELQRHNRSLKEEGV---------QRAR 264
+++ QL E + L E + ++ + ++E+ LC E +L + V QRA
Sbjct: 347 EREKQLRSEFERL--ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAG 404
Query: 265 EEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELR----- 319
E E + S ++ ND+Q + + + ++ + L ERL + +Y LR
Sbjct: 405 EVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGV 464
Query: 320 ----EEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQR 357
+ + + +L D+ L+ Q++L EE R
Sbjct: 465 AAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 506
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 72.4 bits (176), Expect = 1e-12
Identities = 110/539 (20%), Positives = 216/539 (40%), Gaps = 60/539 (11%)
Query: 4 QDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTA 63
+ K+ + + + + E A+ER ++ A E A + E +A+
Sbjct: 2097 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2156
Query: 64 QSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEP 123
++ LR+ +E+ S + + Q E+ A + ++ E +T E
Sbjct: 2157 EARRLRERAEQESARQLQLAQEAAQKRLQA---EEKAHAFAVQQKEQELQQTL---QQEQ 2210
Query: 124 EPTPVVNGEKEPSK-GDPNTEEIR-QSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNT 181
+ GE E ++ EE R Q++ + R+ +E ++ K +E Q
Sbjct: 2211 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA---QARAQ 2267
Query: 182 LSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKL 241
EKL +K AE R +Q L QK+ + EK E + A+ +
Sbjct: 2268 AQAAAEKL----RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2323
Query: 242 ESLCRELQR----HNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSK 297
E LQ H ++L +E +QR + E + S + L +++QME+ ++ ++
Sbjct: 2324 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR 2383
Query: 298 LRQEN---------------MELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQ 342
+ EN E AE++K++ E+ + + + L ++ + +
Sbjct: 2384 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2443
Query: 343 QAQEMLKEAEE------RHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFE- 395
A++MLKE + R + E + L ++ +Q +++ + + QQLA T+ F+
Sbjct: 2444 LAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR 2503
Query: 396 ----EFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKAL--LEMAEE 449
E Q L S+E K + +M++ + E++ +R + E + L E+A +
Sbjct: 2504 TLEAERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2562
Query: 450 KTV------------RDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLSAGGQGSL 496
+ V D + E L+ I LE+ LQ E L + +++ Q L
Sbjct: 2563 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2621
Score = 69.3 bits (168), Expect = 8e-12
Identities = 98/460 (21%), Positives = 192/460 (41%), Gaps = 43/460 (9%)
Query: 28 EGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLEDILSTYC 87
E A E+ Q A EA +QA R+ + Q R + R+ + ++Q + +
Sbjct: 1503 EAALEKQRQLA---EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1559
Query: 88 VDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQ 147
Q E A+ AE AE+SR + + E++ + + +R
Sbjct: 1560 QQLRQSSEAEIQAKARQAEA--AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1617
Query: 148 SDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQ 207
E + R+ QE+ A+ L +++ Q E +LA+ K AE E Q
Sbjct: 1618 RAEEAEAQKRQAQEE--AERLRRQVQDESQRKRQA---EVELASRVKAEAEAARE---KQ 1669
Query: 208 KQMKLLQKKQSQLVQEKDHLR-GEHSKAVLARSKLESLCR----ELQRHNRSLKEEGVQR 262
+ ++ L++ + Q + + LR E +A + LE+ R ELQ S E+ Q
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1729
Query: 263 AREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEH 322
R +E+ V Q+ + ER ++ + E E ++ +E+++L+
Sbjct: 1730 ERSLQEEHVAVA------------QLREEAERRAQQQAEAERAREEAERELERWQLKANE 1777
Query: 323 I-------DKVFKHKDLQQQLVDAKLQQAQEMLK---EAEERHQREKDFLLKEAVESQRM 372
++V + K L Q + + ++A+ + +AEE+ R+++ +E + +++
Sbjct: 1778 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1837
Query: 373 CELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMY 432
E QQ +Q+L + E+ + E ++E T+K ++LE E
Sbjct: 1838 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1897
Query: 433 RSRWE--SSNKALLEMAEEKTVRDKELEGLQVKIQRLEKL 470
R+ E ++KA E E ++ +K + L+ + R +L
Sbjct: 1898 RAEMEVLLASKARAE-EESRSTSEKSKQRLEAEAGRFREL 1936
Score = 62.4 bits (150), Expect = 1e-09
Identities = 106/528 (20%), Positives = 213/528 (40%), Gaps = 75/528 (14%)
Query: 4 QDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTA 63
Q ++ A + + + ++ E AQ R A A + +A R+ + QA
Sbjct: 2236 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2295
Query: 64 QSGAL-------RDVSEELSRQ---LEDILSTYCVD----NNQGGPGEDGAQGEPAEPED 109
Q A + +E+ RQ +E L+T + ++Q ++ Q AE +
Sbjct: 2296 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2355
Query: 110 AEKSRTYVARNG-----------------EPEPTPVVNGEKEPSKG--DPNTEEIRQSDE 150
A + R+ V E E ++ +K+ ++ E+++Q E
Sbjct: 2356 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2415
Query: 151 VGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAAL-----CKKYAELLEEHRN 205
R QE + + L +E L Q +EK+ A+ K AELL++ +
Sbjct: 2416 EAARLSVAAQEAARLRQLAEE-DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2474
Query: 206 -SQKQMKLLQKKQSQLVQE--------KDHLRGEHSKAVLARSKLESLCRELQRHNRSLK 256
+Q+Q + LQ+ + Q+ Q+ + L E + + ++ E L + +R+
Sbjct: 2475 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2534
Query: 257 --EEGVQRAREEEEK------RKEVTSHFQVTL-NDIQLQMEQHNERNSKLRQENMELAE 307
EE QR R++ E+ R E+ + +VTL +++Q +Q + +LR+ EL
Sbjct: 2535 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2594
Query: 308 RLKKLIEQ---YELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREK----- 359
+KL ++ +L+ E + V Q+QL+ Q L E + QRE+
Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTV-----QQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2649
Query: 360 -----DFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQE 414
E ++Q++ E ++Q+ ++Q+ EE + ++ E ++E
Sbjct: 2650 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2709
Query: 415 MEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQV 462
++++ ++ ++ E+ R + L E +E+ QV
Sbjct: 2710 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2757
Score = 55.5 bits (132), Expect = 1e-07
Identities = 114/525 (21%), Positives = 209/525 (39%), Gaps = 82/525 (15%)
Query: 20 PGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQ--ARTAQSGALRDVSEELS- 76
P E E AQ Q E EG G A E + A S A + EL
Sbjct: 1147 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1206
Query: 77 -----RQLEDILSTYCVDNNQGGPGEDGAQGEP----AEPEDAEKSRTYVARNGEPEPTP 127
Q+ + + Y G QG A E ++++ A E E T
Sbjct: 1207 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1266
Query: 128 V------VNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEK---------KKAKGLGKEI 172
E + D +E+R + EVG+R +R E+ + A+ L +
Sbjct: 1267 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1326
Query: 173 TLLMQTLNTLSTPEEKLAALCKKYAEL-------LEEHRNSQKQMKLLQKKQSQLVQEKD 225
+L QT + E+L + Y E L++ R Q+Q++ + SQ V+E+
Sbjct: 1327 AVLAQT-DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ- 1384
Query: 226 HLRGEHSKAVLAR-----SKLESLCRELQRHNRSLKEEGVQRAREEEE--------KRKE 272
LR E +A+L K+E R +++ ++K+ +Q + + K+ +
Sbjct: 1385 -LRQE--QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1441
Query: 273 VTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELRE-------EHIDK 325
V S + + + ++E + Q ++E L+++ E+ L E E + +
Sbjct: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1501
Query: 326 VFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQ 385
V + Q+QL +A Q + +EA+E QR + +E V + +QQ+ +++
Sbjct: 1502 VEAALEKQRQLAEAHAQAKAQAEREAKELQQR----MQEEVVRREEAAVDAQQQKRSIQE 1557
Query: 386 QLALYTEKFEEFQNTLSKSSEVFTTFK-QEMEKMTKKIKKLEKETTMYRSRWESSNKALL 444
+L L +SSE K ++ E + ++E+E + R + E++ +
Sbjct: 1558 EL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER--- 1603
Query: 445 EMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLS 489
++ + EL+ L+ + + E R Q E L ++VQD S
Sbjct: 1604 ----QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1644
Score = 33.9 bits (76), Expect = 0.39
Identities = 35/162 (21%), Positives = 68/162 (41%), Gaps = 21/162 (12%)
Query: 215 KKQSQLVQEKDHLRGEHSKAVLARSKLES-LCRELQRHNRSLKEEGV---------QRAR 264
+++ QL E + L E + ++ + ++E+ LC E +L + V QRA
Sbjct: 516 EREKQLRSEFERL--ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAG 573
Query: 265 EEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELR----- 319
E E + S ++ ND+Q + + + ++ + L ERL + +Y LR
Sbjct: 574 EVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGV 633
Query: 320 ----EEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQR 357
+ + + +L D+ L+ Q++L EE R
Sbjct: 634 AAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHR 675
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.123 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,036,765
Number of Sequences: 37866
Number of extensions: 1290096
Number of successful extensions: 18575
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 473
Number of HSP's successfully gapped in prelim test: 1570
Number of HSP's that attempted gapping in prelim test: 8650
Number of HSP's gapped (non-prelim): 6832
length of query: 546
length of database: 18,247,518
effective HSP length: 107
effective length of query: 439
effective length of database: 14,195,856
effective search space: 6231980784
effective search space used: 6231980784
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.