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Search of human proteins with 28416424
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28416424 Src-like-adaptor 2 isoform b [Homo sapiens]
(210 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28416424 Src-like-adaptor 2 isoform b [Homo sapiens] 435 e-122
gi|14149916 Src-like-adaptor 2 isoform a [Homo sapiens] 364 e-101
gi|194328732 Src-like-adaptor isoform c [Homo sapiens] 146 1e-35
gi|194328725 Src-like-adaptor isoform b [Homo sapiens] 146 1e-35
gi|113930754 Src-like-adaptor isoform a [Homo sapiens] 142 2e-34
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 135 2e-32
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 134 6e-32
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 134 7e-32
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 129 1e-30
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 120 8e-28
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 120 8e-28
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 114 5e-26
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 113 1e-25
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 112 2e-25
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 112 2e-25
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 110 9e-25
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 110 9e-25
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 110 9e-25
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 102 2e-22
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 102 2e-22
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 87 1e-17
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 76 2e-14
gi|4503787 fyn-related kinase [Homo sapiens] 72 4e-13
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 71 8e-13
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 71 8e-13
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 71 8e-13
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 71 8e-13
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 71 8e-13
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 71 8e-13
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 71 8e-13
>gi|28416424 Src-like-adaptor 2 isoform b [Homo sapiens]
Length = 210
Score = 435 bits (1119), Expect = e-122
Identities = 210/210 (100%), Positives = 210/210 (100%)
Query: 1 MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT 60
MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT
Sbjct: 1 MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT 60
Query: 61 IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI 120
IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI
Sbjct: 61 IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI 120
Query: 121 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSEGW 180
RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSEGW
Sbjct: 121 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSEGW 180
Query: 181 PAPWQGYTPTCDCAEDTTQLERAGQLPPVF 210
PAPWQGYTPTCDCAEDTTQLERAGQLPPVF
Sbjct: 181 PAPWQGYTPTCDCAEDTTQLERAGQLPPVF 210
>gi|14149916 Src-like-adaptor 2 isoform a [Homo sapiens]
Length = 261
Score = 364 bits (934), Expect = e-101
Identities = 185/207 (89%), Positives = 188/207 (90%), Gaps = 7/207 (3%)
Query: 1 MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT 60
MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT
Sbjct: 1 MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT 60
Query: 61 IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI 120
IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI
Sbjct: 61 IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI 120
Query: 121 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSEGW 180
RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSE
Sbjct: 121 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSE-- 178
Query: 181 PAPWQGYTPTCDCAEDTTQLERAGQLP 207
C ++ L+RAG LP
Sbjct: 179 -----LADDICCLLKEPCVLQRAGPLP 200
>gi|194328732 Src-like-adaptor isoform c [Homo sapiens]
Length = 316
Score = 146 bits (369), Expect = 1e-35
Identities = 75/174 (43%), Positives = 105/174 (60%), Gaps = 6/174 (3%)
Query: 5 PSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSE 64
P ++K + + S+ + P+ L +P+ + R GE L ++S+
Sbjct: 35 PGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISD 94
Query: 65 DGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 124
+G WW +S +GRE IP + VA+V HGWL+EGL R+KAEELL LP G+F+IRES+
Sbjct: 95 EGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESE 154
Query: 125 TRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSE 178
T++G YSLSVR +++HYRI L N W YISPRLTF L+ LV+HYSE
Sbjct: 155 TKKGFYSLSVR------HRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSE 202
>gi|194328725 Src-like-adaptor isoform b [Homo sapiens]
Length = 293
Score = 146 bits (369), Expect = 1e-35
Identities = 75/174 (43%), Positives = 105/174 (60%), Gaps = 6/174 (3%)
Query: 5 PSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSE 64
P ++K + + S+ + P+ L +P+ + R GE L ++S+
Sbjct: 12 PGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISD 71
Query: 65 DGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 124
+G WW +S +GRE IP + VA+V HGWL+EGL R+KAEELL LP G+F+IRES+
Sbjct: 72 EGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESE 131
Query: 125 TRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSE 178
T++G YSLSVR +++HYRI L N W YISPRLTF L+ LV+HYSE
Sbjct: 132 TKKGFYSLSVR------HRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSE 179
>gi|113930754 Src-like-adaptor isoform a [Homo sapiens]
Length = 276
Score = 142 bits (359), Expect = 2e-34
Identities = 71/139 (51%), Positives = 94/139 (67%), Gaps = 6/139 (4%)
Query: 40 LGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGL 99
L +P+ + R GE L ++S++G WW +S +GRE IP + VA+V HGWL+EGL
Sbjct: 30 LSDYPSPDISPPIFRRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFEGL 89
Query: 100 SREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLY 159
R+KAEELL LP G+F+IRES+T++G YSLSVR +++HYRI L N W Y
Sbjct: 90 GRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVR------HRQVKHYRIFRLPNNWYY 143
Query: 160 ISPRLTFPSLQALVDHYSE 178
ISPRLTF L+ LV+HYSE
Sbjct: 144 ISPRLTFQCLEDLVNHYSE 162
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 135 bits (341), Expect = 2e-32
Identities = 74/172 (43%), Positives = 103/172 (59%), Gaps = 7/172 (4%)
Query: 12 PSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTV 71
P P+ +S P EA VAL + A +LS + G+ + ++ E G+WW
Sbjct: 61 PGPNSHNS---NTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKA 117
Query: 72 LSEVSGREYNIPSVHVAKV----SHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR 127
S + +E IPS +VA+V + W ++G+SR+ AE LL PGN G+F+IR+S+T +
Sbjct: 118 RSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTK 177
Query: 128 GSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSEG 179
GSYSLSVR P D ++HY+I LDNG YISPR TF +LQ LVDHY +G
Sbjct: 178 GSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKG 229
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 134 bits (337), Expect = 6e-32
Identities = 73/177 (41%), Positives = 105/177 (59%), Gaps = 5/177 (2%)
Query: 6 SRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSED 65
S ++ P P S + GQ T + E VAL + P +LS + GE + ++ E
Sbjct: 38 SNKQQRPVPE-SQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEH 96
Query: 66 GDWWTVLSEVSGREYNIPSVHVAKVS----HGWLYEGLSREKAEELLLLPGNPGGAFLIR 121
G+WW S ++ +E IPS +VAK++ W ++ ++R+ AE LL PGN GAFLIR
Sbjct: 97 GEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIR 156
Query: 122 ESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSE 178
ES+T +GS+SLSVR P D I+HY+I LDNG YISPR+TFP + ++ HY +
Sbjct: 157 ESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQK 213
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 134 bits (336), Expect = 7e-32
Identities = 73/174 (41%), Positives = 104/174 (59%), Gaps = 5/174 (2%)
Query: 9 KSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDW 68
K+ P P S + GQ T + E VAL + P +LS + GE + ++ E G+W
Sbjct: 20 KTQPVPE-SQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEW 78
Query: 69 WTVLSEVSGREYNIPSVHVAKVS----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 124
W S ++ +E IPS +VAK++ W ++ ++R+ AE LL PGN GAFLIRES+
Sbjct: 79 WKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESE 138
Query: 125 TRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSE 178
T +GS+SLSVR P D I+HY+I LDNG YISPR+TFP + ++ HY +
Sbjct: 139 TLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQK 192
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 129 bits (325), Expect = 1e-30
Identities = 73/171 (42%), Positives = 96/171 (56%), Gaps = 5/171 (2%)
Query: 25 PVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPS 84
P + K VAL + A +L + GE L ++ GDWW S V+GRE +PS
Sbjct: 51 PPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPS 110
Query: 85 VHVAKVS----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPA 140
VA+V W + R++AE LL P N G+FLIRES+T +G++SLSV+
Sbjct: 111 NFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVK-DVTT 169
Query: 141 SWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSEGWPAPWQGYTPTC 191
+ I+HY+I CLD G YISPR+TFPSLQALV HYS+ Q T C
Sbjct: 170 QGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPC 220
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 120 bits (301), Expect = 8e-28
Identities = 64/144 (44%), Positives = 86/144 (59%), Gaps = 4/144 (2%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVS----HG 93
+AL S+ +L GE L I+ + G+WW S +G+E IP VAK +
Sbjct: 67 IALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEP 126
Query: 94 WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCL 153
W ++ LSR+ AE LL PGN G+FLIRES++ GS+SLSVR + ++HY+I L
Sbjct: 127 WFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNL 186
Query: 154 DNGWLYISPRLTFPSLQALVDHYS 177
DNG YISPR+TFP L LV HY+
Sbjct: 187 DNGGFYISPRITFPGLHELVRHYT 210
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 120 bits (301), Expect = 8e-28
Identities = 64/144 (44%), Positives = 86/144 (59%), Gaps = 4/144 (2%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVS----HG 93
+AL S+ +L GE L I+ + G+WW S +G+E IP VAK +
Sbjct: 67 IALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEP 126
Query: 94 WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCL 153
W ++ LSR+ AE LL PGN G+FLIRES++ GS+SLSVR + ++HY+I L
Sbjct: 127 WFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNL 186
Query: 154 DNGWLYISPRLTFPSLQALVDHYS 177
DNG YISPR+TFP L LV HY+
Sbjct: 187 DNGGFYISPRITFPGLHELVRHYT 210
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 114 bits (286), Expect = 5e-26
Identities = 66/167 (39%), Positives = 91/167 (54%), Gaps = 5/167 (2%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIVSE-DGDWWTVLSEVSGREYNIPSVHVAKV----SH 92
VAL + A +LS + GE I++ +GDWW S +G+ IPS +VA +
Sbjct: 97 VALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAE 156
Query: 93 GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHC 152
W + + R+ AE LLL PGN G FL+RES+T +G+YSLS+R D ++HY+I
Sbjct: 157 EWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRK 216
Query: 153 LDNGWLYISPRLTFPSLQALVDHYSEGWPAPWQGYTPTCDCAEDTTQ 199
LDNG YI+ R F +LQ LV HY+E T C + TQ
Sbjct: 217 LDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQ 263
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 113 bits (283), Expect = 1e-25
Identities = 66/148 (44%), Positives = 84/148 (56%), Gaps = 5/148 (3%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIV-SEDGDWWTVLSEVSGREYNIPSVHVAKV----SH 92
VAL + A +LS GE I+ S +GDWW S +G IPS +VA V +
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
Query: 93 GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHC 152
W + L R+ AE LL GNP G FLIRES+T +G+YSLS+R D ++HY+I
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
Query: 153 LDNGWLYISPRLTFPSLQALVDHYSEGW 180
LDNG YI+ R F +LQ LV HYS W
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHYSGTW 235
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 112 bits (281), Expect = 2e-25
Identities = 66/146 (45%), Positives = 84/146 (57%), Gaps = 5/146 (3%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIV-SEDGDWWTVLSEVSGREYNIPSVHVAKV----SH 92
VAL + A +LS GE I+ S +GDWW S +G IPS +VA V +
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
Query: 93 GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHC 152
W + L R+ AE LL GNP G FLIRES+T +G+YSLS+R D ++HY+I
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
Query: 153 LDNGWLYISPRLTFPSLQALVDHYSE 178
LDNG YI+ R F +LQ LV HYSE
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHYSE 233
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 112 bits (281), Expect = 2e-25
Identities = 66/146 (45%), Positives = 84/146 (57%), Gaps = 5/146 (3%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIV-SEDGDWWTVLSEVSGREYNIPSVHVAKV----SH 92
VAL + A +LS GE I+ S +GDWW S +G IPS +VA V +
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
Query: 93 GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHC 152
W + L R+ AE LL GNP G FLIRES+T +G+YSLS+R D ++HY+I
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
Query: 153 LDNGWLYISPRLTFPSLQALVDHYSE 178
LDNG YI+ R F +LQ LV HYSE
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHYSE 233
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 110 bits (275), Expect = 9e-25
Identities = 63/146 (43%), Positives = 86/146 (58%), Gaps = 5/146 (3%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIVSE-DGDWWTVLSEVSGREYNIPSVHVAKV----SH 92
+AL + A +L+ GE I++ +GDWW S SG+ IPS +VA V +
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
Query: 93 GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHC 152
W + + R+ AE LL PGNP GAFLIRES+T +G+YSLS+R D ++HY+I
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202
Query: 153 LDNGWLYISPRLTFPSLQALVDHYSE 178
LD G YI+ R+ F S+Q LV HY E
Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHYME 228
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 110 bits (275), Expect = 9e-25
Identities = 63/146 (43%), Positives = 86/146 (58%), Gaps = 5/146 (3%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIVSE-DGDWWTVLSEVSGREYNIPSVHVAKV----SH 92
+AL + A +L+ GE I++ +GDWW S SG+ IPS +VA V +
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
Query: 93 GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHC 152
W + + R+ AE LL PGNP GAFLIRES+T +G+YSLS+R D ++HY+I
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202
Query: 153 LDNGWLYISPRLTFPSLQALVDHYSE 178
LD G YI+ R+ F S+Q LV HY E
Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHYME 228
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 110 bits (275), Expect = 9e-25
Identities = 63/146 (43%), Positives = 86/146 (58%), Gaps = 5/146 (3%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIVSE-DGDWWTVLSEVSGREYNIPSVHVAKV----SH 92
+AL + A +L+ GE I++ +GDWW S SG+ IPS +VA V +
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
Query: 93 GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHC 152
W + + R+ AE LL PGNP GAFLIRES+T +G+YSLS+R D ++HY+I
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202
Query: 153 LDNGWLYISPRLTFPSLQALVDHYSE 178
LD G YI+ R+ F S+Q LV HY E
Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHYME 228
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 102 bits (254), Expect = 2e-22
Identities = 64/169 (37%), Positives = 92/169 (54%), Gaps = 5/169 (2%)
Query: 36 TAVALGSFPAGGPAELSLRLGEPLTIVSE-DGDWWTVLSEVSGREYNIPSVHVAKV---- 90
T VAL + + +LS + GE L IV+ +GDWW S +G+ IPS +VA
Sbjct: 88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQ 147
Query: 91 SHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRI 150
+ W + ++R ++E LLL NP G FL+RES+T +G+Y LSV A ++HY+I
Sbjct: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKI 207
Query: 151 HCLDNGWLYISPRLTFPSLQALVDHYSEGWPAPWQGYTPTCDCAEDTTQ 199
LD+G YI+ R F SLQ LV +YS+ T C ++ TQ
Sbjct: 208 RKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQ 256
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 102 bits (254), Expect = 2e-22
Identities = 64/169 (37%), Positives = 92/169 (54%), Gaps = 5/169 (2%)
Query: 36 TAVALGSFPAGGPAELSLRLGEPLTIVSE-DGDWWTVLSEVSGREYNIPSVHVAKV---- 90
T VAL + + +LS + GE L IV+ +GDWW S +G+ IPS +VA
Sbjct: 88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQ 147
Query: 91 SHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRI 150
+ W + ++R ++E LLL NP G FL+RES+T +G+Y LSV A ++HY+I
Sbjct: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKI 207
Query: 151 HCLDNGWLYISPRLTFPSLQALVDHYSEGWPAPWQGYTPTCDCAEDTTQ 199
LD+G YI+ R F SLQ LV +YS+ T C ++ TQ
Sbjct: 208 RKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQ 256
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 86.7 bits (213), Expect = 1e-17
Identities = 56/151 (37%), Positives = 80/151 (52%), Gaps = 14/151 (9%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYN--IPSVHVAKVS---- 91
+AL F A ELS+R G+ L + E+G + +SG+ +P HVAK S
Sbjct: 57 LALYDFTARCGGELSVRRGDRLCAL-EEGGGYIFARRLSGQPSAGLVPITHVAKASPETL 115
Query: 92 --HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYR 149
W + G+SR +A++LLL P N GAFLIR S++ G YSLSVR ++ HYR
Sbjct: 116 SDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQA-----KVCHYR 170
Query: 150 IHCLDNGWLYISPRLTFPSLQALVDHYSEGW 180
+ +G LY+ FP L+ L+ +Y W
Sbjct: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANW 201
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 76.3 bits (186), Expect = 2e-14
Identities = 52/140 (37%), Positives = 74/140 (52%), Gaps = 10/140 (7%)
Query: 37 AVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLY 96
AVA F A G ELS G+ L I+S +W+ +E+ +E +P + W +
Sbjct: 3 AVAKFDFTASGEDELSFHTGDVLKILSNQEEWFK--AELGSQEGYVPKNFIDIQFPKWFH 60
Query: 97 EGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNG 156
EGLSR +AE LL+ G G F+IR SQ+ G +S+SVR D ++H+++ DN
Sbjct: 61 EGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVRHE-----DDVQHFKV-MRDNK 112
Query: 157 WLYISPRLTFPSLQALVDHY 176
Y FPSL LVD+Y
Sbjct: 113 GNYFLWTEKFPSLNKLVDYY 132
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 71.6 bits (174), Expect = 4e-13
Identities = 49/162 (30%), Positives = 79/162 (48%), Gaps = 17/162 (10%)
Query: 29 EAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYN------- 81
+++R VAL + A +LS R G+ L ++ + W + R
Sbjct: 39 QSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQG 98
Query: 82 -IPSVHVAK----VSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRL 136
IPS +VA+ + W + + R AE+ LL N G+FLIRES++++G +SLSV
Sbjct: 99 YIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSV-- 156
Query: 137 SRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSE 178
++HYRI LD G +++ R F +L V HY++
Sbjct: 157 ---LDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTK 195
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 70.9 bits (172), Expect = 8e-13
Identities = 50/146 (34%), Positives = 79/146 (54%), Gaps = 15/146 (10%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKVS---- 91
VAL F A G LS+ GE L ++ + +G+W ++ +G+ + +PS ++ V+
Sbjct: 67 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTK-NGQGW-VPSNYITPVNSLEK 124
Query: 92 HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIH 151
H W + +SR AE LL G+FL+RES++ G S+S+R R+ HYRI+
Sbjct: 125 HSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYE-----GRVYHYRIN 177
Query: 152 CLDNGWLYISPRLTFPSLQALVDHYS 177
+G LY+S F +L LV H+S
Sbjct: 178 TASDGKLYVSSESRFNTLAELVHHHS 203
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 70.9 bits (172), Expect = 8e-13
Identities = 50/146 (34%), Positives = 79/146 (54%), Gaps = 15/146 (10%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKVS---- 91
VAL F A G LS+ GE L ++ + +G+W ++ +G+ + +PS ++ V+
Sbjct: 86 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTK-NGQGW-VPSNYITPVNSLEK 143
Query: 92 HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIH 151
H W + +SR AE LL G+FL+RES++ G S+S+R R+ HYRI+
Sbjct: 144 HSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYE-----GRVYHYRIN 196
Query: 152 CLDNGWLYISPRLTFPSLQALVDHYS 177
+G LY+S F +L LV H+S
Sbjct: 197 TASDGKLYVSSESRFNTLAELVHHHS 222
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 70.9 bits (172), Expect = 8e-13
Identities = 51/146 (34%), Positives = 82/146 (56%), Gaps = 15/146 (10%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKVS---- 91
VAL F A G LS+ GE L ++ +++G+W V S+ +G+ + +PS ++ V+
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSK-NGQGW-VPSNYITPVNSLEK 155
Query: 92 HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIH 151
H W + +SR AE LL N G+FL+RES++ G S+S+R R+ HYRI+
Sbjct: 156 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYE-----GRVYHYRIN 208
Query: 152 CLDNGWLYISPRLTFPSLQALVDHYS 177
+G +Y++ F +L LV H+S
Sbjct: 209 TTADGKVYVTAESRFSTLAELVHHHS 234
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 70.9 bits (172), Expect = 8e-13
Identities = 51/146 (34%), Positives = 82/146 (56%), Gaps = 15/146 (10%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKVS---- 91
VAL F A G LS+ GE L ++ +++G+W V S+ +G+ + +PS ++ V+
Sbjct: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSK-NGQGW-VPSNYITPVNSLEK 170
Query: 92 HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIH 151
H W + +SR AE LL N G+FL+RES++ G S+S+R R+ HYRI+
Sbjct: 171 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYE-----GRVYHYRIN 223
Query: 152 CLDNGWLYISPRLTFPSLQALVDHYS 177
+G +Y++ F +L LV H+S
Sbjct: 224 TTADGKVYVTAESRFSTLAELVHHHS 249
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 70.9 bits (172), Expect = 8e-13
Identities = 51/146 (34%), Positives = 82/146 (56%), Gaps = 15/146 (10%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKVS---- 91
VAL F A G LS+ GE L ++ +++G+W V S+ +G+ + +PS ++ V+
Sbjct: 92 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSK-NGQGW-VPSNYITPVNSLEK 149
Query: 92 HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIH 151
H W + +SR AE LL N G+FL+RES++ G S+S+R R+ HYRI+
Sbjct: 150 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYE-----GRVYHYRIN 202
Query: 152 CLDNGWLYISPRLTFPSLQALVDHYS 177
+G +Y++ F +L LV H+S
Sbjct: 203 TTADGKVYVTAESRFSTLAELVHHHS 228
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 70.9 bits (172), Expect = 8e-13
Identities = 51/146 (34%), Positives = 82/146 (56%), Gaps = 15/146 (10%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKVS---- 91
VAL F A G LS+ GE L ++ +++G+W V S+ +G+ + +PS ++ V+
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSK-NGQGW-VPSNYITPVNSLEK 155
Query: 92 HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIH 151
H W + +SR AE LL N G+FL+RES++ G S+S+R R+ HYRI+
Sbjct: 156 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYE-----GRVYHYRIN 208
Query: 152 CLDNGWLYISPRLTFPSLQALVDHYS 177
+G +Y++ F +L LV H+S
Sbjct: 209 TTADGKVYVTAESRFSTLAELVHHHS 234
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 70.9 bits (172), Expect = 8e-13
Identities = 51/146 (34%), Positives = 82/146 (56%), Gaps = 15/146 (10%)
Query: 38 VALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKVS---- 91
VAL F A G LS+ GE L ++ +++G+W V S+ +G+ + +PS ++ V+
Sbjct: 77 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSK-NGQGW-VPSNYITPVNSLEK 134
Query: 92 HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIH 151
H W + +SR AE LL N G+FL+RES++ G S+S+R R+ HYRI+
Sbjct: 135 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYE-----GRVYHYRIN 187
Query: 152 CLDNGWLYISPRLTFPSLQALVDHYS 177
+G +Y++ F +L LV H+S
Sbjct: 188 TTADGKVYVTAESRFSTLAELVHHHS 213
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,419,227
Number of Sequences: 37866
Number of extensions: 451146
Number of successful extensions: 1581
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 98
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 1382
Number of HSP's gapped (non-prelim): 211
length of query: 210
length of database: 18,247,518
effective HSP length: 98
effective length of query: 112
effective length of database: 14,536,650
effective search space: 1628104800
effective search space used: 1628104800
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.