Search of human proteins with 28373129

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|28373129 contactin 5 isoform short [Homo sapiens]
         (1026 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|28373129 contactin 5 isoform short [Homo sapiens]                 2064   0.0  
gi|7657359 contactin 5 isoform long [Homo sapiens]                   2029   0.0  
gi|28373122 contactin 4 isoform a precursor [Homo sapiens]           1161   0.0  
gi|75709184 contactin 3 [Homo sapiens]                               1139   0.0  
gi|7657361 contactin 6 [Homo sapiens]                                1044   0.0  
gi|4827022 contactin 2 precursor [Homo sapiens]                       899   0.0  
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]            899   0.0  
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]            895   0.0  
gi|28373126 contactin 4 isoform c precursor [Homo sapiens]            734   0.0  
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo...   404   e-112
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ...   404   e-112
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s...   404   e-112
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]           369   e-102
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]            369   e-102
gi|81158224 neuronal cell adhesion molecule isoform B precursor ...   362   e-99 
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]           361   2e-99
gi|81158226 neuronal cell adhesion molecule isoform A precursor ...   358   1e-98
gi|27894376 cell adhesion molecule with homology to L1CAM precur...   347   3e-95
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]           346   6e-95
gi|222352127 sidekick 2 [Homo sapiens]                                275   2e-73
gi|119220552 sidekick 1 [Homo sapiens]                                274   4e-73
gi|28373124 contactin 4 isoform b precursor [Homo sapiens]            249   9e-66
gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]           245   1e-64
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]           244   3e-64
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42...   239   1e-62
gi|19743806 roundabout 1 isoform b [Homo sapiens]                     219   8e-57
gi|4506569 roundabout 1 isoform a [Homo sapiens]                      219   1e-56
gi|224994173 roundabout 1 isoform d [Homo sapiens]                    214   3e-55
gi|224994171 roundabout 1 isoform c [Homo sapiens]                    214   3e-55
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ...   214   3e-55

>gi|28373129 contactin 5 isoform short [Homo sapiens]
          Length = 1026

 Score = 2064 bits (5347), Expect = 0.0
 Identities = 1026/1026 (100%), Positives = 1026/1026 (100%)

Query: 1    MASSWKLMLFLSVTMCLSESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYR 60
            MASSWKLMLFLSVTMCLSESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYR
Sbjct: 1    MASSWKLMLFLSVTMCLSESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYR 60

Query: 61   WLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYL 120
            WLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYL
Sbjct: 61   WLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYL 120

Query: 121  GNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNL 180
            GNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNL
Sbjct: 121  GNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNL 180

Query: 181  YISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAK 240
            YISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAK
Sbjct: 181  YISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAK 240

Query: 241  GTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENS 300
            GTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENS
Sbjct: 241  GTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENS 300

Query: 301  RGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQS 360
            RGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQS
Sbjct: 301  RGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQS 360

Query: 361  RVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVT 420
            RVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVT
Sbjct: 361  RVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVT 420

Query: 421  KDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGE 480
            KDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGE
Sbjct: 421  KDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGE 480

Query: 481  NVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPI 540
            NVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPI
Sbjct: 481  NVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPI 540

Query: 541  DFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPP 600
            DFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPP
Sbjct: 541  DFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPP 600

Query: 601  GIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAM 660
            GIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAM
Sbjct: 601  GIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAM 660

Query: 661  AVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAW 720
            AVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAW
Sbjct: 661  AVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAW 720

Query: 721  EPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVY 780
            EPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVY
Sbjct: 721  EPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVY 780

Query: 781  NNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYW 840
            NNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYW
Sbjct: 781  NNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYW 840

Query: 841  KDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPP 900
            KDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPP
Sbjct: 841  KDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPP 900

Query: 901  SQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVP 960
            SQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVP
Sbjct: 901  SQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVP 960

Query: 961  LPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVTLLLALM 1020
            LPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVTLLLALM
Sbjct: 961  LPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVTLLLALM 1020

Query: 1021 IPSTSW 1026
            IPSTSW
Sbjct: 1021 IPSTSW 1026


>gi|7657359 contactin 5 isoform long [Homo sapiens]
          Length = 1100

 Score = 2029 bits (5256), Expect = 0.0
 Identities = 1008/1008 (100%), Positives = 1008/1008 (100%)

Query: 19   ESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSL 78
            ESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSL
Sbjct: 93   ESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSL 152

Query: 79   IDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQG 138
            IDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQG
Sbjct: 153  IDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQG 212

Query: 139  VVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVK 198
            VVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVK
Sbjct: 213  VVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVK 272

Query: 199  NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTI 258
            NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTI
Sbjct: 273  NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTI 332

Query: 259  TWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHW 318
            TWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHW
Sbjct: 333  TWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHW 392

Query: 319  VEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSD 378
            VEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSD
Sbjct: 393  VEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSD 452

Query: 379  AGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPT 438
            AGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPT
Sbjct: 453  AGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPT 512

Query: 439  ISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPT 498
            ISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPT
Sbjct: 513  ISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPT 572

Query: 499  RIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASS 558
            RIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASS
Sbjct: 573  RIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASS 632

Query: 559  ADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWS 618
            ADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWS
Sbjct: 633  ADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWS 692

Query: 619  PAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATN 678
            PAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATN
Sbjct: 693  PAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATN 752

Query: 679  PIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVA 738
            PIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVA
Sbjct: 753  PIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVA 812

Query: 739  FRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAE 798
            FRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAE
Sbjct: 813  FRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAE 872

Query: 799  GEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNE 858
            GEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNE
Sbjct: 873  GEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNE 932

Query: 859  SFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSL 918
            SFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSL
Sbjct: 933  SFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSL 992

Query: 919  GWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGG 978
            GWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGG
Sbjct: 993  GWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGG 1052

Query: 979  DGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVTLLLALMIPSTSW 1026
            DGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVTLLLALMIPSTSW
Sbjct: 1053 DGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVTLLLALMIPSTSW 1100



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 19/19 (100%), Positives = 19/19 (100%)

Query: 1  MASSWKLMLFLSVTMCLSE 19
          MASSWKLMLFLSVTMCLSE
Sbjct: 1  MASSWKLMLFLSVTMCLSE 19


>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
          Length = 1026

 Score = 1161 bits (3004), Expect = 0.0
 Identities = 561/1023 (54%), Positives = 730/1023 (71%), Gaps = 11/1023 (1%)

Query: 1    MASSWKLMLFLSVTMCLSE-SVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSY 59
            M   W+L++  S  +CL++ S  +GP+F+QEP  ++FP DS+EKKV LNCEV+GNP P  
Sbjct: 1    MRLPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHI 60

Query: 60   RWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAY 119
            RW  NGT++D   D+RYS+++G+ +I+NP++ +D+G YQC ATN+ G+I+SREA LQFAY
Sbjct: 61   RWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAY 120

Query: 120  LGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGN 179
            L NF  RTRS VSVR GQG+VL+C PPPHS E+ Y+W+FNE+PS+  +D+RRF+SQETGN
Sbjct: 121  LDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSY--QDNRRFVSQETGN 178

Query: 180  LYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA 239
            LYI+KV+ SDVG+Y C+V NTVTN +VL PPTPL LRNDGVMGEYEPKIEV FP TV  A
Sbjct: 179  LYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTA 238

Query: 240  KGTTVKMECFALGNPVPTITWMKVNGY-IPSKARLRKSQAVLEIPNVQLDDAGIYECRAE 298
            KG TVK+ECFALGNPVPTI W + +G  I  KAR  KS  +LEIPN Q +DAG+YEC AE
Sbjct: 239  KGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAE 298

Query: 299  NSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSP 358
            NSRGKN  RGQL  Y  P+W++K+ND  +     + WECKA G+P+PTY+WLKNG PL  
Sbjct: 299  NSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLT 358

Query: 359  QSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTII 418
            + R+++  G L I  VN SDAGMYQCLAENK+G I+++AEL ++A  P F+   LK+  +
Sbjct: 359  RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTL 418

Query: 419  VTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCR 478
            V    EVVIECKP+ SPKP  +WKKG   ++EN+RI I  DG+LRI+N +KSD G Y C 
Sbjct: 419  VKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCI 478

Query: 479  GENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQ 538
              N FG+A    +L VK+PTR+ + P   ++TVGESIVL C+  HD SLD+ F W+  G 
Sbjct: 479  ATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGH 538

Query: 539  PIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPG 598
             IDF+ +G HFE +  Q S+ DLMIRNI L HAG+Y C VQT+ D +S  A+L+VRGPPG
Sbjct: 539  LIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPG 598

Query: 599  PPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMES 658
            PP  V ++EIT++TA LSW P  DNHSPI+ Y +QAR+PFS+GWQ V TVPE+I G   +
Sbjct: 599  PPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFT 658

Query: 659  AMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVI 718
            A  V LNPWVEYEFR VA N IG G+PS PS   RT EA+P+  P NVSG  G + ELVI
Sbjct: 659  ATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVI 718

Query: 719  AWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVG 778
             WE V EE QNG GFGY+VAFRP G   W   ++ S++AS++++R+ESV P +PFEVKVG
Sbjct: 719  TWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVG 778

Query: 779  VYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAW-KHIKESLGRPQGFEV 837
            V+NNKG+GPFS   V+ SAE EP+  P  + A S+S ++I V W   ++++ GR QG+EV
Sbjct: 779  VFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEV 838

Query: 838  GYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKK 897
             YW+  ++E+ A  ++T GN++   +T L+G+ LYH  V+AYN AG GP S+ V+ TT+K
Sbjct: 839  KYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRK 898

Query: 898  SPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQA 957
             PPSQ P N+ W    S++ L W+ V  L NESEV GYKV YR    S++ VIET K   
Sbjct: 899  PPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSV 958

Query: 958  VVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYS------GGKITSAQSTLHSLSTSSS 1011
             + LP    YIIE++ +S+GGDG++S QIR+P  S       G  TS   TL ++ST   
Sbjct: 959  ELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMI 1018

Query: 1012 SVT 1014
            S+T
Sbjct: 1019 SLT 1021


>gi|75709184 contactin 3 [Homo sapiens]
          Length = 1028

 Score = 1139 bits (2946), Expect = 0.0
 Identities = 559/1028 (54%), Positives = 725/1028 (70%), Gaps = 8/1028 (0%)

Query: 1    MASSWKLMLFLSVTMCLS-ESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSY 59
            M   WK ++ LS   CL  E +  GPVF++EP + IFP  S++KK+ L+CE RGNP P Y
Sbjct: 1    MMFPWKQLILLSFIGCLGGELLLQGPVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHY 60

Query: 60   RWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAY 119
            RW  NG++ID+  ++RY L  G  ++ NP+   D+G YQC ATN++G+I+SREA LQFAY
Sbjct: 61   RWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAY 120

Query: 120  LGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGN 179
            L NF  + RS VSVREGQGVVL+C PPPHS E+ Y+W+FNE+PSFV EDSRRF+SQETG+
Sbjct: 121  LENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGH 180

Query: 180  LYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA 239
            LYISKV+ SDVG+Y C+V + VTNARVL  PTPL LR+DGVMGEYEPKIEV FP T+ AA
Sbjct: 181  LYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAA 240

Query: 240  KGTTVKMECFALGNPVPTITWMKVNGY-IPSKARLRKSQAVLEIPNVQLDDAGIYECRAE 298
            KG+TVK+ECFALGNP+P I W + +G    SK +LRK   VLEIPN Q +DAG YEC AE
Sbjct: 241  KGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAE 300

Query: 299  NSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSP 358
            NSRGKN  RG+L  Y  PHWV+ + D ++     L WEC+A+GKP+P+YRWLKNG  L  
Sbjct: 301  NSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVL 360

Query: 359  QSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTII 418
            + R ++ NG L I N++ +D+GM+QC+AENK+G +Y+SAELK++ASAP F+ N +KK + 
Sbjct: 361  EERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQ 420

Query: 419  VTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCR 478
            V     V ++CKP+ SP+   SWKKGD +V+E++RI++L DG L+I N +K+D G Y C 
Sbjct: 421  VQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCM 480

Query: 479  GENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQ 538
             EN FG A     L V EPTRI L P   +++VGES++L C+  HD  LD+ F W   G 
Sbjct: 481  AENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGA 540

Query: 539  PIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPG 598
              DF+++G HFE +   +SS DLMIRNI L H+G+Y C VQT  DSVS  A+L+VRG PG
Sbjct: 541  LADFKKDGSHFEKVGG-SSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSPG 599

Query: 599  PPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMES 658
            PP  V V+EIT++TA LSW    DNHSP+ SY++QAR+PFS+GWQTV TVPE+I G   +
Sbjct: 600  PPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHT 659

Query: 659  AMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVI 718
            A  V+LNPWVEYEFRVVA+N IG G+PS PS  +RT EAVP+  P+ V+G  G R ELVI
Sbjct: 660  ATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRSELVI 719

Query: 719  AWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVG 778
             W+PV EE QNGEGFGY+VAFRP G   W + +VTS +  ++++R+ES+ P +P+EVKVG
Sbjct: 720  TWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVG 779

Query: 779  VYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHI--KESLGRPQGFE 836
            VYNNKG+GPFS +  + SAE EP+ AP+ V A S+S SEI V+W  I  K S G   G+E
Sbjct: 780  VYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYE 839

Query: 837  VGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTK 896
            V YW    +E+++  +K  GNE+   L GL+ N  Y+  VRAYN AG GP S+ V+ TTK
Sbjct: 840  VRYWNGGGKEESSSKMKVAGNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTK 899

Query: 897  KSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQ 956
            K+PPSQ P N+ W    ++V L WE V  + NESEV GYKVFYR    +N QV+ T K  
Sbjct: 900  KTPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQNNVQVLNTNKTS 959

Query: 957  AVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVP---SYSGGKITSAQSTLHSLSTSSSSV 1013
            A + LP    YIIEV+A ++GGDGT+S QIR+P   S      TSA S +H +S+    V
Sbjct: 960  AELVLPIKEDYIIEVKATTDGGDGTSSEQIRIPRITSMDARGSTSAISNVHPMSSYMPIV 1019

Query: 1014 TLLLALMI 1021
              L+  ++
Sbjct: 1020 LFLIVYVL 1027


>gi|7657361 contactin 6 [Homo sapiens]
          Length = 1028

 Score = 1044 bits (2700), Expect = 0.0
 Identities = 515/1010 (50%), Positives = 680/1010 (67%), Gaps = 8/1010 (0%)

Query: 5    WKLMLFLS-VTMCLSESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLR 63
            WKL++ L  +     + +   P+F QEP D+IFP D  + +V LNC   G P P YRW +
Sbjct: 5    WKLVILLPLINSSAGDGLLSRPIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRWKQ 64

Query: 64   NGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNF 123
            NGT+ID    Y Y L  G+  I++P   +D G YQCLATN +G+ILSR+A LQFAY+ +F
Sbjct: 65   NGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDF 124

Query: 124  SGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYIS 183
              +TRS VSVREGQGVVL+C PPPH  ++ Y+W FN+ P +V ED+RRF+SQETGNLYI+
Sbjct: 125  ETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIA 184

Query: 184  KVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTT 243
            KV+ SDVG+Y C + N      V  PPTPL  R DGVMGEYEPKIEV FP T+ AAK ++
Sbjct: 185  KVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSS 244

Query: 244  VKMECFALGNPVPTITWMKVNGY-IPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRG 302
            VK+ECFALGNPVP I+W +++G  +P K +  KSQA+LEIPN Q +D G YEC A N RG
Sbjct: 245  VKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRG 304

Query: 303  KNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRV 362
            +N  +GQL  Y  P W +K+ +T L     L WECKA+GKP P Y WLKNG  L+P+ R+
Sbjct: 305  RNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEERI 364

Query: 363  EMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKD 422
            ++ NG L+I  +N SD+G+YQC AENKY  IYA+AEL++LASAP F+ + +KK   V   
Sbjct: 365  QIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVG 424

Query: 423  QEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENV 482
             ++VI CKP   P+  ISWK+G   +R++KRI +L DGSL+I N ++SD G Y C   N 
Sbjct: 425  GDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQ 484

Query: 483  FGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDF 542
            FG+A+   SL VKE T I + P + ++TVGESIVL C+  HD S++V F W   G  ID 
Sbjct: 485  FGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDL 544

Query: 543  EEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGI 602
            ++   HFE I  + S  DLMIRNI L H+G+Y C VQTT +S+S  A+++VRGPPGPP  
Sbjct: 545  KKGVAHFERIGGE-SVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPPGPPED 603

Query: 603  VIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAV 662
            V VE+I+ +T+ LSW    DN+SPI  + +Q R+PFS+GWQ V TVPEI+ G   +A  V
Sbjct: 604  VQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILNGKTYNATVV 663

Query: 663  DLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEP 722
             L+PWVEYEFRVVA N IG G+PS PS ++RT  +VP  AP N+ G  G R ELVI WE 
Sbjct: 664  GLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGGSRSELVITWES 723

Query: 723  VSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNN 782
            + EE QNGEGFGYI+ FRP G+  W ++ V+S E+S+F+YR+ES+ PL+PFEVKVGVYNN
Sbjct: 724  IPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESIIPLSPFEVKVGVYNN 783

Query: 783  KGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHI--KESLGRPQGFEVGYW 840
            +G+G  S + ++ S E EP  AP      S S SE+ V+W  I    + GR  G+EV YW
Sbjct: 784  EGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYW 843

Query: 841  KDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPP 900
             D  +E     ++  GN +   +TGL+ NT+Y  +VRAYN AG GP S  V+ TTKKSPP
Sbjct: 844  TDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAGTGPSSPPVNVTTKKSPP 903

Query: 901  SQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVP 960
            SQ P+N+ W+   S++ L WE V  + NESEV+GYK+ YRQ   S + ++ET    A + 
Sbjct: 904  SQPPANIAWKLTNSKLCLNWEHVKTMENESEVLGYKILYRQNRQSKTHILETNNTSAELL 963

Query: 961  LPDAGVYIIEVRAYSEGGDGTASSQIRVP---SYSGGKITSAQSTLHSLS 1007
            +P    Y+IE+R  S+GGDG++S +IR+P   S S   I   + + H LS
Sbjct: 964  VPFEEDYLIEIRTVSDGGDGSSSEEIRIPKMSSLSSRGIQFLEPSTHFLS 1013


>gi|4827022 contactin 2 precursor [Homo sapiens]
          Length = 1040

 Score =  899 bits (2324), Expect = 0.0
 Identities = 436/968 (45%), Positives = 614/968 (63%), Gaps = 7/968 (0%)

Query: 17  LSESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRY 76
           L     +GPVF  +P  ++FP +S E++V L C  R +P  +YRW  NGTE+ LE   R+
Sbjct: 29  LGSQTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRH 88

Query: 77  SLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREG 136
            L+ G  +I NP++A+D+G YQCLA+N VG+++SREA L+F +L  FS   R  V   EG
Sbjct: 89  QLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEG 148

Query: 137 QGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICL 196
            GV+L C+PP H P + Y W+ NEFP+F+  D R F+SQ TGNLYI++   SD+G+Y CL
Sbjct: 149 WGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCL 208

Query: 197 VKNTV--TNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNP 254
             + +  +   V S    L L  +     + P I+  FP    A  G  V +ECFA GNP
Sbjct: 209 ATSHMDFSTKSVFSKFAQLNLAAEDTR-LFAPSIKARFPAETYALVGQQVTLECFAFGNP 267

Query: 255 VPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYT 314
           VP I W KV+G +    +   ++  L+IP+V  +D G YEC AENS+G+++ +G++ V  
Sbjct: 268 VPRIKWRKVDGSL--SPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQA 325

Query: 315 YPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNV 374
            P W++ ++DT+ D GS LRW C A GKPRPT RWL+NG PL+ Q+RVE++ G L    +
Sbjct: 326 QPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKL 385

Query: 375 NQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGS 434
           +  D+GMYQC+AENK+G IYASAEL + A AP F LN +++ I   +  E++I C+P+ +
Sbjct: 386 SLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAA 445

Query: 435 PKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSV 494
           PK  + W KG   +  + R+ + PDG+L I N S+SDEGKY C  EN  G A     LSV
Sbjct: 446 PKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSV 505

Query: 495 KEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRA 554
           ++ T+I L P   ++ +G+++ L C A HD ++D+TF WTL   PIDF++ GGH+     
Sbjct: 506 RDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNV 565

Query: 555 QASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTAT 614
           + +  DL I N  L H G+Y C  QT  DS S EA +LVRGPPGPPG V+V +I ++T  
Sbjct: 566 KETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQ 625

Query: 615 LSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV 674
           LSWS   DNHSPI+ Y LQAR+P +  W+ V+T P  I G+ E+A  + L PW++YEFRV
Sbjct: 626 LSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRV 685

Query: 675 VATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFG 734
           +A+N +GTG+PS PS  IRT EA P  AP+ +SG  G   EL++ W P+S E+QNG+GFG
Sbjct: 686 IASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFG 745

Query: 735 YIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVI 794
           Y+++FR  G+  W+   V  ++A  F+Y +ESV P TPFEVK+  YN +GDGP S   ++
Sbjct: 746 YLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALV 805

Query: 795 CSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL-GRPQGFEVGYWKDMEQEDTAETVK 853
            SAE EP  APT V A  VS SE+ V W+ +++ + G   G+E+ YWK  ++E  A+ V+
Sbjct: 806 YSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVR 865

Query: 854 TRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQG 913
           T G ++   ++GL  NT YH TVRAYN AG GP S   +ATT K PP + P N+ W    
Sbjct: 866 TAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSS 925

Query: 914 SQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLP-DAGVYIIEVR 972
           S +S+ W+PV+P  NES V GYK+ Y+ + H    +  T K    +P+P D G  ++++R
Sbjct: 926 SSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIR 985

Query: 973 AYSEGGDG 980
               GGDG
Sbjct: 986 TTGPGGDG 993



 Score =  110 bits (276), Expect = 5e-24
 Identities = 211/908 (23%), Positives = 325/908 (35%), Gaps = 128/908 (14%)

Query: 140 VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYI-SKVQTSDVGSYICLVK 198
           VL+      SP   Y W  N     +   SR  +    GNL I +  +  D G Y CL  
Sbjct: 57  VLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVG--GNLVIMNPTKAQDAGVYQCLAS 114

Query: 199 NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN-PVPT 257
           N V    V+S    L     G + E+    E   P  V A +G  V + C    + P  +
Sbjct: 115 NPV--GTVVSREAILRF---GFLQEFSK--EERDP--VKAHEGWGVMLPCNPPAHYPGLS 165

Query: 258 ITWM--KVNGYIPSKARLRKSQAV--LEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 313
             W+  +   +IP+  R   SQ    L I      D G Y C A +      F  +    
Sbjct: 166 YRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHM---DFSTKSVFS 222

Query: 314 TYPHWVEKLNDTQLDS---------------GSPLRWECKATGKPRPTYRWLKNGVPLSP 358
            +        DT+L +               G  +  EC A G P P  +W K    LSP
Sbjct: 223 KFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSP 282

Query: 359 QSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTII 418
           Q         L I +V+  D G Y+C AEN  G       + + A           + + 
Sbjct: 283 QWTT--AEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQP---------EWLK 331

Query: 419 VTKDQEVVIE------CKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDE 472
           V  D E  I       C   G P+PT+ W +    +    R+ +L  G LR    S  D 
Sbjct: 332 VISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLA-GDLRFSKLSLEDS 390

Query: 473 GKYVCRGENVFGSAEIIASLSVKE-PTRIELTPKRTELTV--GESIVLNCKAIHDASLDV 529
           G Y C  EN  G+    A L+V+       L P R  +    G  I++ C+    A+   
Sbjct: 391 GMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQP--RAAPKA 448

Query: 530 TFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEA 589
              W+ KG  I          S         L+IRNI     G+Y C  +      +   
Sbjct: 449 VVLWS-KGTEILVNS------SRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTG 501

Query: 590 ELLVRGP------PGPPGIVIVEEIT-------ESTATLSWSPAADNHSPIS-----SYN 631
            L VR        P    I + + +T       + T  L+++   D+  PI       + 
Sbjct: 502 ILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDF-PIDFDKPGGHY 560

Query: 632 LQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRM 691
            +     ++G  T+    ++  G   + MA  +      E  V+   P G          
Sbjct: 561 RRTNVKETIGDLTILNA-QLRHGGKYTCMAQTVVDSASKEATVLVRGPPGP--------- 610

Query: 692 IRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFG-YIVAFRPNGTRGWKEK 750
                      P  V  R      + ++W   S  F N      Y +  R      WK+ 
Sbjct: 611 -----------PGGVVVRDIGDTTIQLSW---SRGFDNHSPIAKYTLQARTPPAGKWKQV 656

Query: 751 MVTSS--EASKFIYRDESVPPLTPFEVKVGVYNNKGDG-PFSQIVVICSAEGEPSAAPTD 807
               +  E +    +   + P   +E +V   N  G G P      I + E  PS AP+ 
Sbjct: 657 RTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSG 716

Query: 808 VKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTA--ETVKTRGNESFVILTG 865
           +     +  E++V W  +        GF  GY     ++ +   +T +  G ++   +  
Sbjct: 717 LSGGGGAPGELIVNWTPMSREYQNGDGF--GYLLSFRRQGSTHWQTARVPGADAQYFVYS 774

Query: 866 LEG---NTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQ--QGSQVSLGW 920
            E     T +   +R+YN  G GP S      + +  P  AP+ + W +    S++++ W
Sbjct: 775 NESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKV-WAKGVSSSEMNVTW 833

Query: 921 EPVIPLANESEVVGYKVFYRQEGHSNSQV--IETQKLQA---VVPLPDAGVYIIEVRAYS 975
           EPV    N   ++GY++ Y + G   +    + T  L     V  L     Y + VRAY+
Sbjct: 834 EPVQQDMN-GILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYN 892

Query: 976 EGGDGTAS 983
             G G AS
Sbjct: 893 RAGTGPAS 900


>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
          Length = 1007

 Score =  899 bits (2323), Expect = 0.0
 Identities = 456/985 (46%), Positives = 619/985 (62%), Gaps = 17/985 (1%)

Query: 8   MLFLSVTMCLSESVD---YGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRN 64
           ++ +S+T CL+ S +   +GP+F ++P + I+P +S E KV+LNC  R +P P Y+W  N
Sbjct: 10  LVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMN 69

Query: 65  GTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFS 124
             ++DL SD RYS++ G  +I+NP + KD+G Y CLA+N  G + S EATL F YL  F 
Sbjct: 70  NGDVDLTSD-RYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFP 128

Query: 125 GRTRSAVSVREGQGVVLMCSPPPHSPE-IIYSWVFNEFPSFVAEDSRRFISQETGNLYIS 183
              R  V V+EG+G+VL+C PP H P+ + Y W+ NEFP F+  D RRF+SQ  GNLYI+
Sbjct: 129 PEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIA 188

Query: 184 KVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTT 243
            V+ SD G+Y C V +      V S   PL    +     Y   I V F   V A  G  
Sbjct: 189 NVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFK-DVYALMGQN 247

Query: 244 VKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGK 303
           V +ECFALGNPVP I W KV   +PS A +  S AVL+I N+QL+D GIYEC AEN RGK
Sbjct: 248 VTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGK 307

Query: 304 NSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVE 363
           +  + ++ V  +P WVE +NDT++D GS L W C ATGKP PT RWLKNG          
Sbjct: 308 DKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYH------ 361

Query: 364 MVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQ 423
              G L +++V   +AGMYQC+AEN YGAIYA+AELKILA APTF +N +KK I+  K  
Sbjct: 362 --KGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGG 419

Query: 424 EVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVF 483
            V+IECKP+ +PKP  SW KG   +  + RI I  DGSL I N +++D G Y C  EN  
Sbjct: 420 RVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNR 479

Query: 484 GSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFE 543
           G A    +L + +PTRI L P   ++TVGE+  + C A  D +LD+TF W+  G  IDF 
Sbjct: 480 GKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFN 539

Query: 544 EEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIV 603
           +E  H++      S+ +L+IRN  L HAGRY C  QT  D+ S  A+L+VRGPPGPPG +
Sbjct: 540 KENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGL 599

Query: 604 IVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVD 663
            +E+I  ++  L+WS  +DNHSPIS Y +Q ++  S  W+  KT P II G+ME+A AVD
Sbjct: 600 RIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVD 659

Query: 664 LNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPV 723
           L PW+EYEFRVVATN +G G+PS PS  I+T+ A P  AP++V G  GR  EL I W P+
Sbjct: 660 LIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPL 719

Query: 724 SEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNK 783
           S E+  G  FGYIVAF+P     WK+  VT+ +  +++++DE++ P T F+VKV  +NNK
Sbjct: 720 SREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNK 779

Query: 784 GDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDM 843
           GDGP+S + VI SA+  PS APT+V    +S SEI V W+H+ E +   + +++ YW   
Sbjct: 780 GDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKI--VESYQIRYWAAH 837

Query: 844 EQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQA 903
           ++E+ A  V+    E    L  L  +T Y   V A N AG GPPS  + A TKK+PPSQ 
Sbjct: 838 DKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQP 897

Query: 904 PSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPD 963
           P  +   + GS+  + W+ V+ L+NES V GYKV YR +G  + ++  T K    VP+P 
Sbjct: 898 PRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPR 957

Query: 964 AGVYIIEVRAYSEGGDGTASSQIRV 988
            G Y++EVRA+S+GGDG   SQ+++
Sbjct: 958 DGEYVVEVRAHSDGGDGVV-SQVKI 981


>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
          Length = 1018

 Score =  895 bits (2313), Expect = 0.0
 Identities = 457/996 (45%), Positives = 618/996 (62%), Gaps = 28/996 (2%)

Query: 8   MLFLSVTMCLSESVDY--------------GPVFVQEPDDIIFPTDSDEKKVALNCEVRG 53
           ++ +S+T CL+E   Y              GP+F ++P + I+P +S E KV+LNC  R 
Sbjct: 10  LVIISITTCLAEFTWYRRYGHGVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARA 69

Query: 54  NPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREA 113
           +P P Y+W  N  ++DL SD RYS++ G  +I+NP + KD+G Y CLA+N  G + S EA
Sbjct: 70  SPFPVYKWRMNNGDVDLTSD-RYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEA 128

Query: 114 TLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPE-IIYSWVFNEFPSFVAEDSRRF 172
           TL F YL  F    R  V V+EG+G+VL+C PP H P+ + Y W+ NEFP F+  D RRF
Sbjct: 129 TLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRF 188

Query: 173 ISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHF 232
           +SQ  GNLYI+ V+ SD G+Y C V +      V S   PL    +     Y   I V F
Sbjct: 189 VSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQF 248

Query: 233 PFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGI 292
              V A  G  V +ECFALGNPVP I W KV   +PS A +  S AVL+I N+QL+D GI
Sbjct: 249 K-DVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGI 307

Query: 293 YECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN 352
           YEC AEN RGK+  + ++ V  +P WVE +NDT++D GS L W C ATGKP PT RWLKN
Sbjct: 308 YECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKN 367

Query: 353 GVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQ 412
           G             G L +++V   +AGMYQC+AEN YGAIYA+AELKILA APTF +N 
Sbjct: 368 GYAYH--------KGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNP 419

Query: 413 LKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDE 472
           +KK I+  K   V+IECKP+ +PKP  SW KG   +  + RI I  DGSL I N +++D 
Sbjct: 420 MKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDG 479

Query: 473 GKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFY 532
           G Y C  EN  G A    +L + +PTRI L P   ++TVGE+  + C A  D +LD+TF 
Sbjct: 480 GIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFV 539

Query: 533 WTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELL 592
           W+  G  IDF +E  H++      S+ +L+IRN  L HAGRY C  QT  D+ S  A+L+
Sbjct: 540 WSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLV 599

Query: 593 VRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEII 652
           VRGPPGPPG + +E+I  ++  L+WS  +DNHSPIS Y +Q ++  S  W+  KT P II
Sbjct: 600 VRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPII 659

Query: 653 TGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGR 712
            G+ME+A AVDL PW+EYEFRVVATN +G G+PS PS  I+T+ A P  AP++V G  GR
Sbjct: 660 EGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGR 719

Query: 713 RHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP 772
             EL I W P+S E+  G  FGYIVAF+P     WK+  VT+ +  +++++DE++ P T 
Sbjct: 720 NRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTA 779

Query: 773 FEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRP 832
           F+VKV  +NNKGDGP+S + VI SA+  PS APT+V    +S SEI V W+H+ E +   
Sbjct: 780 FQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKI--V 837

Query: 833 QGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVS 892
           + +++ YW   ++E+ A  V+    E    L  L  +T Y   V A N AG GPPS  + 
Sbjct: 838 ESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIE 897

Query: 893 ATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIET 952
           A TKK+PPSQ P  +   + GS+  + W+ V+ L+NES V GYKV YR +G  + ++  T
Sbjct: 898 AFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYST 957

Query: 953 QKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRV 988
            K    VP+P  G Y++EVRA+S+GGDG   SQ+++
Sbjct: 958 HKHSIEVPIPRDGEYVVEVRAHSDGGDGVV-SQVKI 992


>gi|28373126 contactin 4 isoform c precursor [Homo sapiens]
          Length = 698

 Score =  734 bits (1895), Expect = 0.0
 Identities = 358/687 (52%), Positives = 471/687 (68%), Gaps = 7/687 (1%)

Query: 335  WECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIY 394
            WECKA G+P+PTY+WLKNG PL  + R+++  G L I  VN SDAGMYQCLAENK+G I+
Sbjct: 7    WECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIF 66

Query: 395  ASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRI 454
            ++AEL ++A  P F+   LK+  +V    EVVIECKP+ SPKP  +WKKG   ++EN+RI
Sbjct: 67   SNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERI 126

Query: 455  AILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGES 514
             I  DG+LRI+N +KSD G Y C   N FG+A    +L VK+PTR+ + P   ++TVGES
Sbjct: 127  TISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGES 186

Query: 515  IVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRY 574
            IVL C+  HD SLD+ F W+  G  IDF+ +G HFE +  Q S+ DLMIRNI L HAG+Y
Sbjct: 187  IVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKY 246

Query: 575  GCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQA 634
             C VQT+ D +S  A+L+VRGPPGPP  V ++EIT++TA LSW P  DNHSPI+ Y +QA
Sbjct: 247  VCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQA 306

Query: 635  RSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRT 694
            R+PFS+GWQ V TVPE+I G   +A  V LNPWVEYEFR VA N IG G+PS PS   RT
Sbjct: 307  RTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRT 366

Query: 695  NEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTS 754
             EA+P+  P NVSG  G + ELVI WE V EE QNG GFGY+VAFRP G   W   ++ S
Sbjct: 367  EEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLAS 426

Query: 755  SEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVS 814
            ++AS++++R+ESV P +PFEVKVGV+NNKG+GPFS   V+ SAE EP+  P  + A S+S
Sbjct: 427  ADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLS 486

Query: 815  VSEILVAWKH-IKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYH 873
             ++I V W   ++++ GR QG+EV YW+  ++E+ A  ++T GN++   +T L+G+ LYH
Sbjct: 487  ATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYH 546

Query: 874  FTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVV 933
              V+AYN AG GP S+ V+ TT+K PPSQ P N+ W    S++ L W+ V  L NESEV 
Sbjct: 547  LAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVK 606

Query: 934  GYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYS- 992
            GYKV YR    S++ VIET K    + LP    YIIE++ +S+GGDG++S QIR+P  S 
Sbjct: 607  GYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISN 666

Query: 993  -----GGKITSAQSTLHSLSTSSSSVT 1014
                  G  TS   TL ++ST   S+T
Sbjct: 667  AYARGSGASTSNACTLSAISTIMISLT 693



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 80/267 (29%), Positives = 115/267 (43%), Gaps = 22/267 (8%)

Query: 247 ECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSF 306
           EC A G P PT  W+K    + ++ R++  Q  L I  V L DAG+Y+C AEN  G    
Sbjct: 8   ECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFS 67

Query: 307 RGQLQVYTY-PHWVEKL--NDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVE 363
             +L V    P +   L    T +  G  +  ECK    P+P Y W K    L    R+ 
Sbjct: 68  NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERIT 127

Query: 364 M-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKD 422
           +  +G L I NV +SDAG Y C+A N +G   AS+   ++   PT  +     ++ VT  
Sbjct: 128 ISEDGNLRIINVTKSDAGSYTCIATNHFGT--ASSTGNLVVKDPTRVMVP-PSSMDVTVG 184

Query: 423 QEVVIECK--PQGSPKPTISW----------KKGDRAVRENKRIAILPDGSLRILNASKS 470
           + +V+ C+     S     +W          + GD   R   + +    G L I N    
Sbjct: 185 ESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSA---GDLMIRNIQLK 241

Query: 471 DEGKYVCRGENVFGSAEIIASLSVKEP 497
             GKYVC  +         A L V+ P
Sbjct: 242 HAGKYVCMVQTSVDRLSAAADLIVRGP 268



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 164/729 (22%), Positives = 265/729 (36%), Gaps = 121/729 (16%)

Query: 42  EKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLA 101
           E+ V   C+  G P P+Y+WL+NG  + L  D R  +  GT  I+  +   D+G YQCLA
Sbjct: 2   EENVFWECKANGRPKPTYKWLKNGEPL-LTRD-RIQIEQGTLNITIVN-LSDAGMYQCLA 58

Query: 102 TNTVGSILSREATLQFAYLGNFSGRT--RSAVSVREGQGVVLMCSPPPHSPEIIYSWVFN 159
            N  G I S  A L    +G    RT  +    V+ G  VV+ C P   SP+ +Y+W   
Sbjct: 59  ENKHGVIFS-NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKA-SPKPVYTW--- 113

Query: 160 EFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNA------------RVL 207
           +    + +++ R    E GNL I  V  SD GSY C+  N    A            RV+
Sbjct: 114 KKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVM 173

Query: 208 SPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYI 267
            PP+ +    D  +GE      +  P  VT      +              TW   NG++
Sbjct: 174 VPPSSM----DVTVGE-----SIVLPCQVTHDHSLDI------------VFTW-SFNGHL 211

Query: 268 P---------SKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHW 318
                      +   + S   L I N+QL  AG Y C  + S  + S    L V   P  
Sbjct: 212 IDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGP 271

Query: 319 VEKLN-DTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSP---QSRVEMVNGVLMIHNV 374
            E +  D   D+ + L W      +P P      N  P++    Q+R     G   +  V
Sbjct: 272 PEAVTIDEITDTTAQLSW------RPGP-----DNHSPITMYVIQARTPFSVGWQAVSTV 320

Query: 375 NQSDAGMYQCLAENKYGA-IYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQ- 432
            +   G  +       G   +   E + +A A    + +  +     + +E + E  P  
Sbjct: 321 PELIDG--KTFTATVVGLNPWVEYEFRTVA-ANVIGIGEPSRPSEKRRTEEALPEVTPAN 377

Query: 433 ----GSPKP--TISWKKGDRAVRENKR----IAILPDGSL--RILNASKSDEGKYVCRGE 480
               G  K    I+W+     ++  +     +A  P G +   +   + +D  +YV R E
Sbjct: 378 VSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNE 437

Query: 481 NVFGSAEIIASLSV-KEPTRIELTPKRTELTVGESIVLNCKAIHDASL---DVTFYWT-- 534
           +V   +     + V         +P     +  E       +I   SL   D+  +W   
Sbjct: 438 SVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASP 497

Query: 535 -------LKGQPI------DFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTT 581
                  ++G  +      D EE      ++  Q S+    ++  +L H          T
Sbjct: 498 LEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGT 557

Query: 582 ADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWS--PAADNHSPISSYNLQARSPFS 639
             S +       + PP  P   I+   ++S   L+W    A DN S +  Y +  R    
Sbjct: 558 GPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYR---- 613

Query: 640 LGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVP 699
             W    +   I T      +++  +     E  ++   P   G   + S  IR    +P
Sbjct: 614 --WNRQSSTSVIETNKTSVELSLPFD-----EDYIIEIKPFSDGGDGSSSEQIR----IP 662

Query: 700 KTAPTNVSG 708
           K +     G
Sbjct: 663 KISNAYARG 671


>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
           sapiens]
          Length = 1248

 Score =  404 bits (1037), Expect = e-112
 Identities = 280/943 (29%), Positives = 451/943 (47%), Gaps = 70/943 (7%)

Query: 34  IIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLID----GTFIISNPS 89
           ++FPTD     ++L CE  G P   +RW R+G     + +   ++      G+F I+  +
Sbjct: 41  VVFPTDD----ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNN 96

Query: 90  E---AKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 146
                +  G Y+C A+N +G+ +S E  L       +   T   V V EG+ VVL C+PP
Sbjct: 97  SNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPP 156

Query: 147 PHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGS-YICLVKNTVTNAR 205
           P +  +   W+ N     + +D R  + Q  GNLY + V TSD  S YIC      T   
Sbjct: 157 PSAEPLRIYWM-NSKILHIKQDERVTMGQN-GNLYFANVLTSDNHSDYICHAHFPGTRTI 214

Query: 206 VLSPPTPLTLRNDGVMGEYEPKIEVHFPFT----VTAAKGTTVKMECFALGNPVPTITWM 261
           +   P  L ++    M + +P++   FP      + A +G  + +EC A G P PTI W+
Sbjct: 215 IQKEPIDLRVKATNSMIDRKPRLL--FPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWL 272

Query: 262 KVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVE 320
           + +G +P+ +   +     L++  V  +D G Y C AENS G       + V   P+W+ 
Sbjct: 273 RPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLH 332

Query: 321 KLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVP---LSPQSRVEMVNGVLMIHNVNQS 377
           K        G   R +C+  G+P+P   W  NG+P   L+   +  +  G L++ NV  S
Sbjct: 333 KPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPS 392

Query: 378 DAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKP 437
           D  + QC A N++G + A+A + ++   P   L    +T +  +     + CK  G+P P
Sbjct: 393 DTMVTQCEARNRHGLLLANAYIYVV-QLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVP 451

Query: 438 TISWKKGD-RAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE 496
           ++ W   D   V +++R     +G+L I +   +D G+Y C   N   +  I+A+L VK+
Sbjct: 452 SVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKD 511

Query: 497 PTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQA 556
            T+I   P+ T    G  +   C+A  D SL  +  W  +G   D +E G   +S +   
Sbjct: 512 ATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITW--RGDGRDLQELG---DSDKYFI 566

Query: 557 SSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEI---TESTA 613
               L+I ++     G Y C   T  D V   A+LLV G PGP   +++ ++   T+S  
Sbjct: 567 EDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQV 626

Query: 614 TLSWSPAADNHSPISSYNLQARSPFSLG--WQTVKTVPEIITGDMESAMAVDLNPWVEYE 671
            +SWSPA D+++PI  Y+++          W ++  VP       +++  + L+P+V Y 
Sbjct: 627 RVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVP-----GNQTSTTLKLSPYVHYT 681

Query: 672 FRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGE 731
           FRV A N  G G+PS  S  + T EA P+  P +V G       +VI W+P+     N  
Sbjct: 682 FRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAP 741

Query: 732 GFGYIVAFRPNGTRG-WKEKMVTS-----SEASKFIYRDESVPPLTPFEVKVGVYNNKGD 785
              Y V +RP GTRG W+E++V+      S  S F+          P+E+KV   N++G 
Sbjct: 742 QVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFV----------PYEIKVQAVNSQGK 791

Query: 786 GPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWK--HIKESLGRPQGFEVGYWKDM 843
           GP  Q+ +  S E  P A P       ++ S +LV W+   + +  G  +G+ V YW++ 
Sbjct: 792 GPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREG 851

Query: 844 EQEDTA------ETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKK 897
            Q   +      + V    N + VIL+GL   + YH  V+A+NG G G P+SE + +T +
Sbjct: 852 SQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSG-PASEFTFSTPE 910

Query: 898 SPPSQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGYKVFY 939
             P   P  L  E Q  + + L W+P  PL++   + GY + Y
Sbjct: 911 GVPGH-PEALHLECQSNTSLLLRWQP--PLSHNGVLTGYVLSY 950



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 160/698 (22%), Positives = 265/698 (37%), Gaps = 91/698 (13%)

Query: 330 GSPLRWECKATGKPRPTYRWLKNGVPLSPQSRV--EMVNGVLMIHNVNQSDAGMYQCLAE 387
           G PL  EC A G P PT +WL+   P+ P  RV  +  N  L +  V + D G Y+CLAE
Sbjct: 252 GQPLVLECIAEGFPTPTIKWLRPSGPM-PADRVTYQNHNKTLQLLKVGEEDDGEYRCLAE 310

Query: 388 NKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRA 447
           N  G+  A     +   A  + L++  ++ +    +   ++C+ QG P+P ++W+     
Sbjct: 311 NSLGS--ARHAYYVTVEAAPYWLHK-PQSHLYGPGETARLDCQVQGRPQPEVTWRINGIP 367

Query: 448 VRE--NKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE-PTRIELTP 504
           V E    +   +  G+L + N   SD     C   N  G     A + V + P +I    
Sbjct: 368 VEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTAD 427

Query: 505 KRTELTV-GESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMI 563
            +T + V G +  L CKA   A +    +    G  +  +E    +       ++  L I
Sbjct: 428 NQTYMAVQGSTAYLLCKAF-GAPVPSVQWLDEDGTTVLQDERFFPY-------ANGTLGI 479

Query: 564 RNILLMHAGRYGCRVQTTADSVSDEAELLVRGPP----GPPGIVIVEEITESTATLSWSP 619
           R++     GRY C      ++V+  A L V+       GP   +   E   S  T +   
Sbjct: 480 RDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTI---EKKGSRVTFTCQA 536

Query: 620 AAD-NHSPISSYNLQARSPFSLGWQTVKTVPE--IITGDMESAMAVDLNPWVEYEFRVVA 676
           + D +  P  ++    R    LG      + +  ++   ++ +   + +     E  VV 
Sbjct: 537 SFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVE 596

Query: 677 TNP--IGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFG 734
           +    +  G P    R++ ++  +   +   VS      H   I  E    EF++ E   
Sbjct: 597 SRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPI--EKYDIEFEDKE--- 651

Query: 735 YIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDG---PFSQI 791
                 P   + +    V  ++ S  +     + P   +  +V   N  G G   P S+ 
Sbjct: 652 ----MAPE--KWYSLGKVPGNQTSTTL----KLSPYVHYTFRVTAINKYGPGEPSPVSET 701

Query: 792 VVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK-----------ESLGRPQGFEVGYW 840
           VV  + E  P   P DVK      + +++ WK ++               RPQG   G W
Sbjct: 702 VV--TPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTR-GPW 758

Query: 841 KDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPP 900
           ++    D            F++++       Y   V+A N  G GP        + +  P
Sbjct: 759 QEQIVSDP-----------FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYP 807

Query: 901 SQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGYKVFYRQEG----HSNSQVIETQKL 955
              P     E    S V + W PV     +  + GY V Y +EG    HS   +    K 
Sbjct: 808 QAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHI---HKD 864

Query: 956 QAVVPLPDAGV----------YIIEVRAYSEGGDGTAS 983
             VVP     V          Y +EV+A++  G G AS
Sbjct: 865 HVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS 902



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 31/139 (22%), Positives = 55/139 (39%), Gaps = 12/139 (8%)

Query: 406 PTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAIL-----PDG 460
           P     Q  + ++V    ++ ++C+  G P+    W +     +  + + +        G
Sbjct: 29  PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 88

Query: 461 SLRIL----NASKSDEGKYVCRGENVFGSA--EIIASLSVKEPTRIELTPKRTELTVGES 514
           S  I     N ++  +G Y C   N  G+A    I  ++   P   + T K  E+  GES
Sbjct: 89  SFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGES 148

Query: 515 IVLNCKAIHDASLDVTFYW 533
           +VL C     A   +  YW
Sbjct: 149 VVLPCNPPPSAE-PLRIYW 166



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 31/135 (22%), Positives = 60/135 (44%), Gaps = 19/135 (14%)

Query: 595  GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTV----PE 650
            G PG P  + +E  + ++  L W P   ++  ++ Y L    P   G +   +     PE
Sbjct: 911  GVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYH-PLDEGGKGQLSFNLRDPE 969

Query: 651  IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPT---NVS 707
            + T ++      DL+P + Y F++ AT   G G+      ++R    +  +  +   N+S
Sbjct: 970  LRTHNL-----TDLSPHLRYRFQLQATTKEGPGE-----AIVREGGTMALSGISDFGNIS 1019

Query: 708  GRSGRRHELVIAWEP 722
              +G  +  V++W P
Sbjct: 1020 ATAGENYS-VVSWVP 1033


>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
           sapiens]
          Length = 1253

 Score =  404 bits (1037), Expect = e-112
 Identities = 280/943 (29%), Positives = 451/943 (47%), Gaps = 70/943 (7%)

Query: 34  IIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLID----GTFIISNPS 89
           ++FPTD     ++L CE  G P   +RW R+G     + +   ++      G+F I+  +
Sbjct: 46  VVFPTDD----ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNN 101

Query: 90  E---AKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 146
                +  G Y+C A+N +G+ +S E  L       +   T   V V EG+ VVL C+PP
Sbjct: 102 SNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPP 161

Query: 147 PHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGS-YICLVKNTVTNAR 205
           P +  +   W+ N     + +D R  + Q  GNLY + V TSD  S YIC      T   
Sbjct: 162 PSAEPLRIYWM-NSKILHIKQDERVTMGQN-GNLYFANVLTSDNHSDYICHAHFPGTRTI 219

Query: 206 VLSPPTPLTLRNDGVMGEYEPKIEVHFPFT----VTAAKGTTVKMECFALGNPVPTITWM 261
           +   P  L ++    M + +P++   FP      + A +G  + +EC A G P PTI W+
Sbjct: 220 IQKEPIDLRVKATNSMIDRKPRLL--FPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWL 277

Query: 262 KVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVE 320
           + +G +P+ +   +     L++  V  +D G Y C AENS G       + V   P+W+ 
Sbjct: 278 RPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLH 337

Query: 321 KLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVP---LSPQSRVEMVNGVLMIHNVNQS 377
           K        G   R +C+  G+P+P   W  NG+P   L+   +  +  G L++ NV  S
Sbjct: 338 KPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPS 397

Query: 378 DAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKP 437
           D  + QC A N++G + A+A + ++   P   L    +T +  +     + CK  G+P P
Sbjct: 398 DTMVTQCEARNRHGLLLANAYIYVV-QLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVP 456

Query: 438 TISWKKGD-RAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE 496
           ++ W   D   V +++R     +G+L I +   +D G+Y C   N   +  I+A+L VK+
Sbjct: 457 SVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKD 516

Query: 497 PTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQA 556
            T+I   P+ T    G  +   C+A  D SL  +  W  +G   D +E G   +S +   
Sbjct: 517 ATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITW--RGDGRDLQELG---DSDKYFI 571

Query: 557 SSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEI---TESTA 613
               L+I ++     G Y C   T  D V   A+LLV G PGP   +++ ++   T+S  
Sbjct: 572 EDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQV 631

Query: 614 TLSWSPAADNHSPISSYNLQARSPFSLG--WQTVKTVPEIITGDMESAMAVDLNPWVEYE 671
            +SWSPA D+++PI  Y+++          W ++  VP       +++  + L+P+V Y 
Sbjct: 632 RVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVP-----GNQTSTTLKLSPYVHYT 686

Query: 672 FRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGE 731
           FRV A N  G G+PS  S  + T EA P+  P +V G       +VI W+P+     N  
Sbjct: 687 FRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAP 746

Query: 732 GFGYIVAFRPNGTRG-WKEKMVTS-----SEASKFIYRDESVPPLTPFEVKVGVYNNKGD 785
              Y V +RP GTRG W+E++V+      S  S F+          P+E+KV   N++G 
Sbjct: 747 QVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFV----------PYEIKVQAVNSQGK 796

Query: 786 GPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWK--HIKESLGRPQGFEVGYWKDM 843
           GP  Q+ +  S E  P A P       ++ S +LV W+   + +  G  +G+ V YW++ 
Sbjct: 797 GPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREG 856

Query: 844 EQEDTA------ETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKK 897
            Q   +      + V    N + VIL+GL   + YH  V+A+NG G G P+SE + +T +
Sbjct: 857 SQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSG-PASEFTFSTPE 915

Query: 898 SPPSQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGYKVFY 939
             P   P  L  E Q  + + L W+P  PL++   + GY + Y
Sbjct: 916 GVPGH-PEALHLECQSNTSLLLRWQP--PLSHNGVLTGYVLSY 955



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 160/698 (22%), Positives = 265/698 (37%), Gaps = 91/698 (13%)

Query: 330 GSPLRWECKATGKPRPTYRWLKNGVPLSPQSRV--EMVNGVLMIHNVNQSDAGMYQCLAE 387
           G PL  EC A G P PT +WL+   P+ P  RV  +  N  L +  V + D G Y+CLAE
Sbjct: 257 GQPLVLECIAEGFPTPTIKWLRPSGPM-PADRVTYQNHNKTLQLLKVGEEDDGEYRCLAE 315

Query: 388 NKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRA 447
           N  G+  A     +   A  + L++  ++ +    +   ++C+ QG P+P ++W+     
Sbjct: 316 NSLGS--ARHAYYVTVEAAPYWLHK-PQSHLYGPGETARLDCQVQGRPQPEVTWRINGIP 372

Query: 448 VRE--NKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE-PTRIELTP 504
           V E    +   +  G+L + N   SD     C   N  G     A + V + P +I    
Sbjct: 373 VEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTAD 432

Query: 505 KRTELTV-GESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMI 563
            +T + V G +  L CKA   A +    +    G  +  +E    +       ++  L I
Sbjct: 433 NQTYMAVQGSTAYLLCKAF-GAPVPSVQWLDEDGTTVLQDERFFPY-------ANGTLGI 484

Query: 564 RNILLMHAGRYGCRVQTTADSVSDEAELLVRGPP----GPPGIVIVEEITESTATLSWSP 619
           R++     GRY C      ++V+  A L V+       GP   +   E   S  T +   
Sbjct: 485 RDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTI---EKKGSRVTFTCQA 541

Query: 620 AAD-NHSPISSYNLQARSPFSLGWQTVKTVPE--IITGDMESAMAVDLNPWVEYEFRVVA 676
           + D +  P  ++    R    LG      + +  ++   ++ +   + +     E  VV 
Sbjct: 542 SFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVE 601

Query: 677 TNP--IGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFG 734
           +    +  G P    R++ ++  +   +   VS      H   I  E    EF++ E   
Sbjct: 602 SRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPI--EKYDIEFEDKE--- 656

Query: 735 YIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDG---PFSQI 791
                 P   + +    V  ++ S  +     + P   +  +V   N  G G   P S+ 
Sbjct: 657 ----MAPE--KWYSLGKVPGNQTSTTL----KLSPYVHYTFRVTAINKYGPGEPSPVSET 706

Query: 792 VVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK-----------ESLGRPQGFEVGYW 840
           VV  + E  P   P DVK      + +++ WK ++               RPQG   G W
Sbjct: 707 VV--TPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTR-GPW 763

Query: 841 KDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPP 900
           ++    D            F++++       Y   V+A N  G GP        + +  P
Sbjct: 764 QEQIVSDP-----------FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYP 812

Query: 901 SQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGYKVFYRQEG----HSNSQVIETQKL 955
              P     E    S V + W PV     +  + GY V Y +EG    HS   +    K 
Sbjct: 813 QAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHI---HKD 869

Query: 956 QAVVPLPDAGV----------YIIEVRAYSEGGDGTAS 983
             VVP     V          Y +EV+A++  G G AS
Sbjct: 870 HVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS 907



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 31/139 (22%), Positives = 55/139 (39%), Gaps = 12/139 (8%)

Query: 406 PTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAIL-----PDG 460
           P     Q  + ++V    ++ ++C+  G P+    W +     +  + + +        G
Sbjct: 34  PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93

Query: 461 SLRIL----NASKSDEGKYVCRGENVFGSA--EIIASLSVKEPTRIELTPKRTELTVGES 514
           S  I     N ++  +G Y C   N  G+A    I  ++   P   + T K  E+  GES
Sbjct: 94  SFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGES 153

Query: 515 IVLNCKAIHDASLDVTFYW 533
           +VL C     A   +  YW
Sbjct: 154 VVLPCNPPPSAE-PLRIYW 171



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 31/135 (22%), Positives = 60/135 (44%), Gaps = 19/135 (14%)

Query: 595  GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTV----PE 650
            G PG P  + +E  + ++  L W P   ++  ++ Y L    P   G +   +     PE
Sbjct: 916  GVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYH-PLDEGGKGQLSFNLRDPE 974

Query: 651  IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPT---NVS 707
            + T ++      DL+P + Y F++ AT   G G+      ++R    +  +  +   N+S
Sbjct: 975  LRTHNL-----TDLSPHLRYRFQLQATTKEGPGE-----AIVREGGTMALSGISDFGNIS 1024

Query: 708  GRSGRRHELVIAWEP 722
              +G  +  V++W P
Sbjct: 1025 ATAGENYS-VVSWVP 1038


>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
           sapiens]
          Length = 1257

 Score =  404 bits (1037), Expect = e-112
 Identities = 280/943 (29%), Positives = 451/943 (47%), Gaps = 70/943 (7%)

Query: 34  IIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLID----GTFIISNPS 89
           ++FPTD     ++L CE  G P   +RW R+G     + +   ++      G+F I+  +
Sbjct: 46  VVFPTDD----ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNN 101

Query: 90  E---AKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 146
                +  G Y+C A+N +G+ +S E  L       +   T   V V EG+ VVL C+PP
Sbjct: 102 SNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPP 161

Query: 147 PHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGS-YICLVKNTVTNAR 205
           P +  +   W+ N     + +D R  + Q  GNLY + V TSD  S YIC      T   
Sbjct: 162 PSAEPLRIYWM-NSKILHIKQDERVTMGQN-GNLYFANVLTSDNHSDYICHAHFPGTRTI 219

Query: 206 VLSPPTPLTLRNDGVMGEYEPKIEVHFPFT----VTAAKGTTVKMECFALGNPVPTITWM 261
           +   P  L ++    M + +P++   FP      + A +G  + +EC A G P PTI W+
Sbjct: 220 IQKEPIDLRVKATNSMIDRKPRLL--FPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWL 277

Query: 262 KVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVE 320
           + +G +P+ +   +     L++  V  +D G Y C AENS G       + V   P+W+ 
Sbjct: 278 RPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLH 337

Query: 321 KLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVP---LSPQSRVEMVNGVLMIHNVNQS 377
           K        G   R +C+  G+P+P   W  NG+P   L+   +  +  G L++ NV  S
Sbjct: 338 KPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPS 397

Query: 378 DAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKP 437
           D  + QC A N++G + A+A + ++   P   L    +T +  +     + CK  G+P P
Sbjct: 398 DTMVTQCEARNRHGLLLANAYIYVV-QLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVP 456

Query: 438 TISWKKGD-RAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE 496
           ++ W   D   V +++R     +G+L I +   +D G+Y C   N   +  I+A+L VK+
Sbjct: 457 SVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKD 516

Query: 497 PTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQA 556
            T+I   P+ T    G  +   C+A  D SL  +  W  +G   D +E G   +S +   
Sbjct: 517 ATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITW--RGDGRDLQELG---DSDKYFI 571

Query: 557 SSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEI---TESTA 613
               L+I ++     G Y C   T  D V   A+LLV G PGP   +++ ++   T+S  
Sbjct: 572 EDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQV 631

Query: 614 TLSWSPAADNHSPISSYNLQARSPFSLG--WQTVKTVPEIITGDMESAMAVDLNPWVEYE 671
            +SWSPA D+++PI  Y+++          W ++  VP       +++  + L+P+V Y 
Sbjct: 632 RVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVP-----GNQTSTTLKLSPYVHYT 686

Query: 672 FRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGE 731
           FRV A N  G G+PS  S  + T EA P+  P +V G       +VI W+P+     N  
Sbjct: 687 FRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAP 746

Query: 732 GFGYIVAFRPNGTRG-WKEKMVTS-----SEASKFIYRDESVPPLTPFEVKVGVYNNKGD 785
              Y V +RP GTRG W+E++V+      S  S F+          P+E+KV   N++G 
Sbjct: 747 QVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFV----------PYEIKVQAVNSQGK 796

Query: 786 GPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWK--HIKESLGRPQGFEVGYWKDM 843
           GP  Q+ +  S E  P A P       ++ S +LV W+   + +  G  +G+ V YW++ 
Sbjct: 797 GPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREG 856

Query: 844 EQEDTA------ETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKK 897
            Q   +      + V    N + VIL+GL   + YH  V+A+NG G G P+SE + +T +
Sbjct: 857 SQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSG-PASEFTFSTPE 915

Query: 898 SPPSQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGYKVFY 939
             P   P  L  E Q  + + L W+P  PL++   + GY + Y
Sbjct: 916 GVPGH-PEALHLECQSNTSLLLRWQP--PLSHNGVLTGYVLSY 955



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 160/698 (22%), Positives = 265/698 (37%), Gaps = 91/698 (13%)

Query: 330 GSPLRWECKATGKPRPTYRWLKNGVPLSPQSRV--EMVNGVLMIHNVNQSDAGMYQCLAE 387
           G PL  EC A G P PT +WL+   P+ P  RV  +  N  L +  V + D G Y+CLAE
Sbjct: 257 GQPLVLECIAEGFPTPTIKWLRPSGPM-PADRVTYQNHNKTLQLLKVGEEDDGEYRCLAE 315

Query: 388 NKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRA 447
           N  G+  A     +   A  + L++  ++ +    +   ++C+ QG P+P ++W+     
Sbjct: 316 NSLGS--ARHAYYVTVEAAPYWLHK-PQSHLYGPGETARLDCQVQGRPQPEVTWRINGIP 372

Query: 448 VRE--NKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE-PTRIELTP 504
           V E    +   +  G+L + N   SD     C   N  G     A + V + P +I    
Sbjct: 373 VEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTAD 432

Query: 505 KRTELTV-GESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMI 563
            +T + V G +  L CKA   A +    +    G  +  +E    +       ++  L I
Sbjct: 433 NQTYMAVQGSTAYLLCKAF-GAPVPSVQWLDEDGTTVLQDERFFPY-------ANGTLGI 484

Query: 564 RNILLMHAGRYGCRVQTTADSVSDEAELLVRGPP----GPPGIVIVEEITESTATLSWSP 619
           R++     GRY C      ++V+  A L V+       GP   +   E   S  T +   
Sbjct: 485 RDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTI---EKKGSRVTFTCQA 541

Query: 620 AAD-NHSPISSYNLQARSPFSLGWQTVKTVPE--IITGDMESAMAVDLNPWVEYEFRVVA 676
           + D +  P  ++    R    LG      + +  ++   ++ +   + +     E  VV 
Sbjct: 542 SFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVE 601

Query: 677 TNP--IGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFG 734
           +    +  G P    R++ ++  +   +   VS      H   I  E    EF++ E   
Sbjct: 602 SRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPI--EKYDIEFEDKE--- 656

Query: 735 YIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDG---PFSQI 791
                 P   + +    V  ++ S  +     + P   +  +V   N  G G   P S+ 
Sbjct: 657 ----MAPE--KWYSLGKVPGNQTSTTL----KLSPYVHYTFRVTAINKYGPGEPSPVSET 706

Query: 792 VVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK-----------ESLGRPQGFEVGYW 840
           VV  + E  P   P DVK      + +++ WK ++               RPQG   G W
Sbjct: 707 VV--TPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTR-GPW 763

Query: 841 KDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPP 900
           ++    D            F++++       Y   V+A N  G GP        + +  P
Sbjct: 764 QEQIVSDP-----------FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYP 812

Query: 901 SQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGYKVFYRQEG----HSNSQVIETQKL 955
              P     E    S V + W PV     +  + GY V Y +EG    HS   +    K 
Sbjct: 813 QAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHI---HKD 869

Query: 956 QAVVPLPDAGV----------YIIEVRAYSEGGDGTAS 983
             VVP     V          Y +EV+A++  G G AS
Sbjct: 870 HVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS 907



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 31/139 (22%), Positives = 55/139 (39%), Gaps = 12/139 (8%)

Query: 406 PTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAIL-----PDG 460
           P     Q  + ++V    ++ ++C+  G P+    W +     +  + + +        G
Sbjct: 34  PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93

Query: 461 SLRIL----NASKSDEGKYVCRGENVFGSA--EIIASLSVKEPTRIELTPKRTELTVGES 514
           S  I     N ++  +G Y C   N  G+A    I  ++   P   + T K  E+  GES
Sbjct: 94  SFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGES 153

Query: 515 IVLNCKAIHDASLDVTFYW 533
           +VL C     A   +  YW
Sbjct: 154 VVLPCNPPPSAE-PLRIYW 171



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 31/135 (22%), Positives = 60/135 (44%), Gaps = 19/135 (14%)

Query: 595  GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTV----PE 650
            G PG P  + +E  + ++  L W P   ++  ++ Y L    P   G +   +     PE
Sbjct: 916  GVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYH-PLDEGGKGQLSFNLRDPE 974

Query: 651  IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPT---NVS 707
            + T ++      DL+P + Y F++ AT   G G+      ++R    +  +  +   N+S
Sbjct: 975  LRTHNL-----TDLSPHLRYRFQLQATTKEGPGE-----AIVREGGTMALSGISDFGNIS 1024

Query: 708  GRSGRRHELVIAWEP 722
              +G  +  V++W P
Sbjct: 1025 ATAGENYS-VVSWVP 1038


>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
          Length = 1174

 Score =  369 bits (948), Expect = e-102
 Identities = 286/988 (28%), Positives = 437/988 (44%), Gaps = 84/988 (8%)

Query: 5   WKLMLFLSVTMCLSESVDYGPVFVQEP--------DDIIFPTDSDEKKVALNCEVRGNPV 56
           W    FL   + L  +++      Q P        D I+ P D+    + + CE +GNP 
Sbjct: 9   WVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDN----ILIECEAKGNPA 64

Query: 57  PSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPSEAKDS---GHYQCLATNTVGSILSR 111
           PS+ W RN    ++  D R S+    GT +I   S  +     G YQC A N  G+ LS 
Sbjct: 65  PSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN 124

Query: 112 EATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRR 171
              LQ +    +       V V+EG  + L C+PPP  P  +  W+ +     + +D R 
Sbjct: 125 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEP-ITQDKR- 182

Query: 172 FISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA---------RVLS--PPTPLTLRND 218
            +SQ   G+LY S V   D+ + Y C  +   T+          +VL+  P    +LRN 
Sbjct: 183 -VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNH 241

Query: 219 GVM----GEYEPKIEVHFPFTVTAA----KGTTVKMECFALGNPVPTITWMKVNGYIPS- 269
             M    G  E      +P    ++    +G  + +EC A G P P I W K  G +PS 
Sbjct: 242 PDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSD 301

Query: 270 KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDS 329
           KA+       L I NV  +D+G Y C A N  G       ++V   P+W+++  +  L  
Sbjct: 302 KAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAP 361

Query: 330 GSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQSDAGMYQCLA 386
           G   R  C+A G P+PT +W+ NG PL    P    E+    ++  +   S   +YQC  
Sbjct: 362 GEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNT 421

Query: 387 ENKYGAIYASAELKILASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGSPKPTISW-KK 443
            N++G + A+A + +L   P      NQL + I+  + +   ++C   GSP PT+ W K 
Sbjct: 422 SNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKN 478

Query: 444 GDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELT 503
           G  +  +     +  +GSL I    K D+G Y C   N+ G AE    L VK+PTRI   
Sbjct: 479 GQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRM 538

Query: 504 PKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMI 563
           P+      G ++ L C+  HD SL +T  W    +P+        +   R +     L I
Sbjct: 539 PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNRMKKEDDSLTI 590

Query: 564 RNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADN 623
             +     G Y C   T  D    +A L V G P  P  + + ++ E +  L+W P   N
Sbjct: 591 FGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDAN 650

Query: 624 HSPISSYNLQ-ARSPFSLG-WQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIG 681
           +SPI+ Y +Q     F  G W      P    G + SA+ + L+P+V Y+FRV+A N +G
Sbjct: 651 NSPITDYVVQFEEDQFQPGVWHDHSKYP----GSVNSAV-LRLSPYVNYQFRVIAINEVG 705

Query: 682 TGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRP 741
           +  PS PS   RT+ A P++ P +V G   R++ + I W P++     G    YIV +R 
Sbjct: 706 SSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRR 765

Query: 742 NGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGE 800
             TR  W    V  S      Y     P   P+E++V   N+ G GP  + V+  S E  
Sbjct: 766 RETREAWNNVTVWGSR-----YVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDY 820

Query: 801 PSAAPTDVKATSVSVSEILVAWKHIKESL--GRPQGFEVGYWKDMEQEDTAETVKTRGNE 858
           P AAPT+VK   ++ + I + W  +      G+ + +   YW++          + R   
Sbjct: 821 PRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQA 880

Query: 859 SFV------ILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQ 912
           SF       +++ L   + Y   +   NG G GP S     TT +  PS AP   R  Q 
Sbjct: 881 SFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPS-APRRFRVRQP 939

Query: 913 GSQ-VSLGWEPVIPLANESEVVGYKVFY 939
             + ++L W+   P      ++GY + Y
Sbjct: 940 NLETINLEWDH--PEHPNGIMIGYTLKY 965



 Score = 31.2 bits (69), Expect = 5.2
 Identities = 27/111 (24%), Positives = 42/111 (37%), Gaps = 2/111 (1%)

Query: 595  GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG 654
            G P  P    V +    T  L W      +  +  Y L+  + F+ G +  K + E  + 
Sbjct: 926  GVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVA-FN-GTKVGKQIVENFSP 983

Query: 655  DMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN 705
            +         +P   Y F + A   +G+G+  T       NEA P  A TN
Sbjct: 984  NQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTN 1034


>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
          Length = 1169

 Score =  369 bits (948), Expect = e-102
 Identities = 286/988 (28%), Positives = 437/988 (44%), Gaps = 84/988 (8%)

Query: 5   WKLMLFLSVTMCLSESVDYGPVFVQEP--------DDIIFPTDSDEKKVALNCEVRGNPV 56
           W    FL   + L  +++      Q P        D I+ P D+    + + CE +GNP 
Sbjct: 9   WVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDN----ILIECEAKGNPA 64

Query: 57  PSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPSEAKDS---GHYQCLATNTVGSILSR 111
           PS+ W RN    ++  D R S+    GT +I   S  +     G YQC A N  G+ LS 
Sbjct: 65  PSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN 124

Query: 112 EATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRR 171
              LQ +    +       V V+EG  + L C+PPP  P  +  W+ +     + +D R 
Sbjct: 125 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEP-ITQDKR- 182

Query: 172 FISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA---------RVLS--PPTPLTLRND 218
            +SQ   G+LY S V   D+ + Y C  +   T+          +VL+  P    +LRN 
Sbjct: 183 -VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNH 241

Query: 219 GVM----GEYEPKIEVHFPFTVTAA----KGTTVKMECFALGNPVPTITWMKVNGYIPS- 269
             M    G  E      +P    ++    +G  + +EC A G P P I W K  G +PS 
Sbjct: 242 PDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSD 301

Query: 270 KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDS 329
           KA+       L I NV  +D+G Y C A N  G       ++V   P+W+++  +  L  
Sbjct: 302 KAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAP 361

Query: 330 GSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQSDAGMYQCLA 386
           G   R  C+A G P+PT +W+ NG PL    P    E+    ++  +   S   +YQC  
Sbjct: 362 GEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNT 421

Query: 387 ENKYGAIYASAELKILASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGSPKPTISW-KK 443
            N++G + A+A + +L   P      NQL + I+  + +   ++C   GSP PT+ W K 
Sbjct: 422 SNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKN 478

Query: 444 GDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELT 503
           G  +  +     +  +GSL I    K D+G Y C   N+ G AE    L VK+PTRI   
Sbjct: 479 GQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRM 538

Query: 504 PKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMI 563
           P+      G ++ L C+  HD SL +T  W    +P+        +   R +     L I
Sbjct: 539 PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNRMKKEDDSLTI 590

Query: 564 RNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADN 623
             +     G Y C   T  D    +A L V G P  P  + + ++ E +  L+W P   N
Sbjct: 591 FGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDAN 650

Query: 624 HSPISSYNLQ-ARSPFSLG-WQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIG 681
           +SPI+ Y +Q     F  G W      P    G + SA+ + L+P+V Y+FRV+A N +G
Sbjct: 651 NSPITDYVVQFEEDQFQPGVWHDHSKYP----GSVNSAV-LRLSPYVNYQFRVIAINEVG 705

Query: 682 TGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRP 741
           +  PS PS   RT+ A P++ P +V G   R++ + I W P++     G    YIV +R 
Sbjct: 706 SSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRR 765

Query: 742 NGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGE 800
             TR  W    V  S      Y     P   P+E++V   N+ G GP  + V+  S E  
Sbjct: 766 RETREAWNNVTVWGSR-----YVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDY 820

Query: 801 PSAAPTDVKATSVSVSEILVAWKHIKESL--GRPQGFEVGYWKDMEQEDTAETVKTRGNE 858
           P AAPT+VK   ++ + I + W  +      G+ + +   YW++          + R   
Sbjct: 821 PRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQA 880

Query: 859 SFV------ILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQ 912
           SF       +++ L   + Y   +   NG G GP S     TT +  PS AP   R  Q 
Sbjct: 881 SFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPS-APRRFRVRQP 939

Query: 913 GSQ-VSLGWEPVIPLANESEVVGYKVFY 939
             + ++L W+   P      ++GY + Y
Sbjct: 940 NLETINLEWDH--PEHPNGIMIGYTLKY 965


>gi|81158224 neuronal cell adhesion molecule isoform B precursor
           [Homo sapiens]
          Length = 1183

 Score =  362 bits (929), Expect = e-99
 Identities = 273/942 (28%), Positives = 423/942 (44%), Gaps = 76/942 (8%)

Query: 29  QEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGT--FIIS 86
           Q P D I       + + + CE +G P PS+ W RNGT  D++ D   ++  GT   II+
Sbjct: 45  QSPKDYII---DPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIIN 101

Query: 87  NPSEAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMC 143
             SE K     G YQC A N  G+ +S    ++ +    ++      ++++ GQ +VL C
Sbjct: 102 IMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPC 161

Query: 144 SPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGS-YICLVKNTVT 202
            PP   P  I  W+ N F       S R      G+LY S V   D    YIC  +    
Sbjct: 162 RPPIGLPPPIIFWMDNSFQRL--PQSERVSQGLNGDLYFSNVLPEDTREDYICYAR--FN 217

Query: 203 NARVLSPPTPLTLR-------NDGVMGE------YEPKIEVHFPFTVTAA---------- 239
           + + +    P++++       ND +         Y  K     P T              
Sbjct: 218 HTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEEL 277

Query: 240 KGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKS-QAVLEIPNVQLDDAGIYECRAE 298
           +G  + +EC A G P P I W K +G +P    + K+ +  L+I +V   D+G Y+C A+
Sbjct: 278 RGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAK 337

Query: 299 NSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPL-- 356
           N+ G       ++V   P+W+    +  L  G      C+A G P+P   WL NGVP+  
Sbjct: 338 NALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEI 397

Query: 357 SPQSRVEMVNG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKK 415
           +P      ++G  ++  NV +  + +YQC A N+YG + A+A + +LA  P   L     
Sbjct: 398 APDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRI-LTPANT 456

Query: 416 TIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPD-GSLRILNASKSDEGK 474
              V  ++  +++C   GSP PTI W KG +    ++ I +L + G+L I  A K   G 
Sbjct: 457 LYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGT 516

Query: 475 YVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWT 534
           Y C   N  G A+    L +K+PT I   P+   +  G  +   CK  HD +L +T  W 
Sbjct: 517 YTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWL 576

Query: 535 LKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVR 594
              + +  +E        R       L++ ++    +G Y C   TT DSVS  A L V 
Sbjct: 577 KDNRELPSDE--------RFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVV 628

Query: 595 GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQ----ARSPFSLGWQTVKTVPE 650
             P PP  + + +  + +  LSW+P  DN+SPI+ + ++       P     QT      
Sbjct: 629 DVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTE----- 683

Query: 651 IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRS 710
            ++G   +A  + L+P+V Y FRV+A N IG   PS  S    T  + P   PT V G  
Sbjct: 684 -VSGTQTTAQ-LKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLG 741

Query: 711 GRRHELVIAWEPVSEEFQNGEGFGYIVAFR-PNGTRGWKEKMVTSSEASKFIYRDESVPP 769
                LVI W+P++    NG G  Y V++R  +G   W   +V  +  SK+I      P 
Sbjct: 742 SEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVV--ANVSKYIV--SGTPT 797

Query: 770 LTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHI--KE 827
             P+ +KV   N+ G  P   +V+  S E  P  AP +V+   V+ +   V W  +  K 
Sbjct: 798 FVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKS 857

Query: 828 SLGRPQGFEVGYWKDMEQED------TAETVKTRGNESFVILTGLEGNTLYHFTVRAYNG 881
             G  QG+ + YWK              + +  +G+++  +L GLE  + Y   VR  NG
Sbjct: 858 IRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNG 917

Query: 882 AGYGPPSSEVSATTKKSPPSQAPSNLRWEQQG-SQVSLGWEP 922
            G GP S +    T +  PS APS+L+        ++L W+P
Sbjct: 918 KGEGPASPDRVFNTPEGVPS-APSSLKIVNPTLDSLTLEWDP 958



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 35/130 (26%), Positives = 60/130 (46%), Gaps = 14/130 (10%)

Query: 402 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 459
           L   PT    Q  K  I+   + +VI+C+ +G P P+ SW +      + ++  + + P 
Sbjct: 36  LVQPPTIT-QQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPG 94

Query: 460 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 510
               I+N      +++ EG Y C   N  G+A  +++  V  P+R  L  K       L 
Sbjct: 95  TGTLIINIMSEGKAETYEGVYQCTARNERGAA--VSNNIVVRPSRSPLWTKEKLEPITLQ 152

Query: 511 VGESIVLNCK 520
            G+S+VL C+
Sbjct: 153 SGQSLVLPCR 162


>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
          Length = 1189

 Score =  361 bits (926), Expect = 2e-99
 Identities = 286/1003 (28%), Positives = 438/1003 (43%), Gaps = 99/1003 (9%)

Query: 5   WKLMLFLSVTMCLSESVDYGPVFVQEP--------DDIIFPTDSDEKKVALNCEVRGNPV 56
           W    FL   + L  +++      Q P        D I+ P D+    + + CE +GNP 
Sbjct: 9   WVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDN----ILIECEAKGNPA 64

Query: 57  PSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPSEAKDS---GHYQCLATNTVGSILSR 111
           PS+ W RN    ++  D R S+    GT +I   S  +     G YQC A N  G+ LS 
Sbjct: 65  PSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN 124

Query: 112 EATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRR 171
              LQ +    +       V V+EG  + L C+PPP  P  +  W+ +     + +D R 
Sbjct: 125 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEP-ITQDKR- 182

Query: 172 FISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA---------RVLS--PPTPLTLRND 218
            +SQ   G+LY S V   D+ + Y C  +   T+          +VL+  P    +LRN 
Sbjct: 183 -VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNH 241

Query: 219 GVM----GEYEPKIEVHFPFTVTAA----KGTTVKMECFALGNPVPTITWMKVNGYIPS- 269
             M    G  E      +P    ++    +G  + +EC A G P P I W K  G +PS 
Sbjct: 242 PDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSD 301

Query: 270 KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDS 329
           KA+       L I NV  +D+G Y C A N  G       ++V   P+W+++  +  L  
Sbjct: 302 KAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAP 361

Query: 330 GSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQSDAGMYQCLA 386
           G   R  C+A G P+PT +W+ NG PL    P    E+    ++  +   S   +YQC  
Sbjct: 362 GEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNT 421

Query: 387 ENKYGAIYASAELKILASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGSPKPTISW-KK 443
            N++G + A+A + +L   P      NQL + I+  + +   ++C   GSP PT+ W K 
Sbjct: 422 SNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKN 478

Query: 444 GDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELT 503
           G  +  +     +  +GSL I    K D+G Y C   N+ G AE    L VK+PTRI   
Sbjct: 479 GQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRM 538

Query: 504 PKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMI 563
           P+      G ++ L C+  HD SL +T  W    +P+        +   R +     L I
Sbjct: 539 PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNRMKKEDDSLTI 590

Query: 564 RNILLMHAGRYGCRVQTTADSVSDEAELLV---------------RGPPGPPGIVIVEEI 608
             +     G Y C   T  D    +A L V               +G P  P  + + ++
Sbjct: 591 FGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDL 650

Query: 609 TESTATLSWSPAADNHSPISSYNLQ-ARSPFSLG-WQTVKTVPEIITGDMESAMAVDLNP 666
            E +  L+W P   N+SPI+ Y +Q     F  G W      P    G + SA+ + L+P
Sbjct: 651 AERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP----GSVNSAV-LRLSP 705

Query: 667 WVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEE 726
           +V Y+FRV+A N +G+  PS PS   RT+ A P++ P +V G   R++ + I W P++  
Sbjct: 706 YVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNAT 765

Query: 727 FQNGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGD 785
              G    YIV +R   TR  W    V  S      Y     P   P+E++V   N+ G 
Sbjct: 766 SAFGPNLRYIVKWRRRETREAWNNVTVWGSR-----YVVGQTPVYVPYEIRVQAENDFGK 820

Query: 786 GPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL--GRPQGFEVGYWKDM 843
           GP  + V+  S E  P AAPT+VK   ++ + I + W  +      G+ + +   YW++ 
Sbjct: 821 GPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRES 880

Query: 844 EQEDTAETVKTRGNESFV------ILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKK 897
                    + R   SF       +++ L   + Y   +   NG G GP S     TT +
Sbjct: 881 SLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPE 940

Query: 898 SPPSQAPSNLRWEQQGSQ-VSLGWEPVIPLANESEVVGYKVFY 939
             PS AP   R  Q   + ++L W+   P      ++GY + Y
Sbjct: 941 GVPS-APRRFRVRQPNLETINLEWDH--PEHPNGIMIGYTLKY 980



 Score = 31.2 bits (69), Expect = 5.2
 Identities = 27/111 (24%), Positives = 42/111 (37%), Gaps = 2/111 (1%)

Query: 595  GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG 654
            G P  P    V +    T  L W      +  +  Y L+  + F+ G +  K + E  + 
Sbjct: 941  GVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVA-FN-GTKVGKQIVENFSP 998

Query: 655  DMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN 705
            +         +P   Y F + A   +G+G+  T       NEA P  A TN
Sbjct: 999  NQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTN 1049


>gi|81158226 neuronal cell adhesion molecule isoform A precursor
           [Homo sapiens]
          Length = 1304

 Score =  358 bits (919), Expect = 1e-98
 Identities = 276/964 (28%), Positives = 428/964 (44%), Gaps = 86/964 (8%)

Query: 17  LSESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRY 76
           L + V    +  Q P D I       + + + CE +G P PS+ W RNGT  D++ D   
Sbjct: 39  LEDLVQPPTITQQSPKDYII---DPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLV 95

Query: 77  SLIDGT--FIISNPSEAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAV 131
           ++  GT   II+  SE K     G YQC A N  G+ +S    ++ +    ++      +
Sbjct: 96  TMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPI 155

Query: 132 SVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVG 191
           +++ GQ +VL C PP   P  I  W+ N F       S R      G+LY S V   D  
Sbjct: 156 TLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRL--PQSERVSQGLNGDLYFSNVLPEDTR 213

Query: 192 S-YICLVKNTVTNARVLSPPTPLTLR-------NDGVMGE------YEPKIEVHFPFTVT 237
             YIC  +    + + +    P++++       ND +         Y  K     P T  
Sbjct: 214 EDYICYAR--FNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFL 271

Query: 238 AA----------KGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKS-QAVLEIPNVQ 286
                       +G  + +EC A G P P I W K +G +P    + K+ +  L+I +V 
Sbjct: 272 TPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVS 331

Query: 287 LDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPT 346
             D+G Y+C A+N+ G       ++V   P+W+    +  L  G      C+A G P+P 
Sbjct: 332 EADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPR 391

Query: 347 YRWLKNGVPL--SPQSRVEMVNG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILA 403
             WL NGVP+  +P      ++G  ++  NV +  + +YQC A N+YG + A+A + +LA
Sbjct: 392 ISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLA 451

Query: 404 SAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPD-GSL 462
             P   L        V  ++  +++C   GSP PTI W KG +    ++ I +L + G+L
Sbjct: 452 EPPRI-LTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTL 510

Query: 463 RILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAI 522
            I  A K   G Y C   N  G A+    L +K+PT I   P+   +  G  +   CK  
Sbjct: 511 EIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVK 570

Query: 523 HDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTA 582
           HD +L +T  W    + +  +E        R       L++ ++    +G Y C   TT 
Sbjct: 571 HDHTLSLTVLWLKDNRELPSDE--------RFTVDKDHLVVADVSDDDSGTYTCVANTTL 622

Query: 583 DSVSDEAELLVRGP----------PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNL 632
           DSVS  A L V  P          P PP  + + +  + +  LSW+P  DN+SPI+ + +
Sbjct: 623 DSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFII 682

Query: 633 Q----ARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTP 688
           +       P     QT       ++G   +A  + L+P+V Y FRV+A N IG   PS  
Sbjct: 683 EYEDAMHKPGLWHHQTE------VSGTQTTAQ-LKLSPYVNYSFRVMAVNSIGKSLPSEA 735

Query: 689 SRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFR-PNGTRGW 747
           S    T  + P   PT V G       LVI W+P++    NG G  Y V++R  +G   W
Sbjct: 736 SEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEW 795

Query: 748 KEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTD 807
              +V  +  SK+I      P   P+ +KV   N+ G  P   +V+  S E  P  AP +
Sbjct: 796 TSVVV--ANVSKYIV--SGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGN 851

Query: 808 VKATSVSVSEILVAWKHI--KESLGRPQGFEVGYWKDMEQED------TAETVKTRGNES 859
           V+   V+ +   V W  +  K   G  QG+ + YWK              + +  +G+++
Sbjct: 852 VRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKT 911

Query: 860 FVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQG-SQVSL 918
             +L GLE  + Y   VR  NG G GP S +    T +  PS APS+L+        ++L
Sbjct: 912 HGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPS-APSSLKIVNPTLDSLTL 970

Query: 919 GWEP 922
            W+P
Sbjct: 971 EWDP 974



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 42/198 (21%), Positives = 80/198 (40%), Gaps = 12/198 (6%)

Query: 595  GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG 654
            G P  P  + +   T  + TL W P +  +  ++ Y L+ + P +   +    V   I  
Sbjct: 950  GVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQ-PINSTHELGPLVDLKIPA 1008

Query: 655  DMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEA---VPKTAPTNVSGRSG 711
            +       +LN    Y+F   A    G+G   T   +   +EA    P      V   + 
Sbjct: 1009 NKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNP 1068

Query: 712  RRHELVIA----WEPVSEEFQNGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDES 766
            R   L  A    +  +S E++  E   + V +   G++  W++++V  S +    +  + 
Sbjct: 1069 RISNLTAAAAETYANISWEYEGPEHVNFYVEYGVAGSKEEWRKEIVNGSRS---FFGLKG 1125

Query: 767  VPPLTPFEVKVGVYNNKG 784
            + P T ++V+VG   + G
Sbjct: 1126 LMPGTAYKVRVGAVGDSG 1143


>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
           [Homo sapiens]
          Length = 1224

 Score =  347 bits (890), Expect = 3e-95
 Identities = 264/987 (26%), Positives = 434/987 (43%), Gaps = 86/987 (8%)

Query: 7   LMLFLSVTMCLSESVDYGPVFVQEPD-DIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNG 65
           L+L  S  + +  SV   P  +++    + FP D   +   + CE +GNP P++ W ++G
Sbjct: 17  LLLKFSKAIEIPSSVQQVPTIIKQSKVQVAFPFD---EYFQIECEAKGNPEPTFSWTKDG 73

Query: 66  TEIDLESDYRY--SLIDGTFIISNPSEAKD-SGHYQCLATNTVGSILSREATLQFAYLGN 122
                 +D+R   S   GTF I N        G Y+C A+N +G  +S E       +  
Sbjct: 74  NPFYF-TDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPK 132

Query: 123 FSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYI 182
           F       + V EG  +VL C+PP   P +   W+  E    + +D R ++SQ+ G+LY 
Sbjct: 133 FPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIEL-EHIEQDERVYMSQK-GDLYF 190

Query: 183 SKVQTSDVGSYIC------------------LVKNTVTNARVLSPPTPLTLRNDGVMGEY 224
           + V+  D  +  C                  L  N++ +A   S  T +  + + +  + 
Sbjct: 191 ANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIK-QR 249

Query: 225 EPKI-----EVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQA- 278
           +PK+     E     ++T  KG  + +ECFA G P P + W K+ G +P     +++   
Sbjct: 250 KPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGK 309

Query: 279 VLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECK 338
            L+I NV   D G Y C A N  G  +    + V   P W +K       +GS     C+
Sbjct: 310 TLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCE 369

Query: 339 ATGKPRPTYRWLKNGVPLS--PQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYAS 396
           A G+P+PT +W  NG P+   P +   +    +   N+  +   +YQC A N +G I A+
Sbjct: 370 AEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILAN 429

Query: 397 AELKILASAPTFALNQLKKTIIVTKDQE---------VVIECKPQGSPKPTISWKKGDRA 447
           A + ++   P          +I TKD E           + C+   SP+  +SW+K +  
Sbjct: 430 ANIDVVDVRP----------LIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEV 479

Query: 448 VR-ENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR 506
              E +R  I  +G+L+I   ++ D G Y C  EN  G   + A+L ++  T++ ++PK 
Sbjct: 480 KPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKN 539

Query: 507 TELTVGESIVLNCKAIHDASL--DVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIR 564
             +     + L+C++  D+ L   +   W+  G+   FE  G   E  R     A+L I 
Sbjct: 540 PRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEA--FEINGT--EDGRIIIDGANLTIS 595

Query: 565 NILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNH 624
           N+ L   G Y C   T  DS +D  ++ V   P PP  + + E    +  L+W   AD++
Sbjct: 596 NVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHN 655

Query: 625 SPISSY--NLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGT 682
           S IS Y    +        W+ +  V        ++ + + L P+V Y+FRV+A N +G 
Sbjct: 656 SNISEYIVEFEGNKEEPGRWEELTRVQ-----GKKTTVILPLAPFVRYQFRVIAVNEVGR 710

Query: 683 GDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPN 742
             PS PS    T  A P   P N+  ++ +  E++I WEP+    QNG G  Y V ++P 
Sbjct: 711 SQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQ 770

Query: 743 GTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEP 801
           G    W+E+ VT+        R  +     P++VKV   N  G GP  Q V + S E  P
Sbjct: 771 GAPVEWEEETVTN-----HTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYP 825

Query: 802 SAAPTDVKATSVSVSEILVAWKHIKESL--GRPQGFEVGYWKDMEQED------TAETVK 853
             AP       ++ + + V W  + +    GR +G+++ +WK     D          ++
Sbjct: 826 DTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILR 885

Query: 854 TRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQG 913
             G  +  ++  L+  + +H TV AYN  G GP S      T +  P Q       +   
Sbjct: 886 FSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDK 945

Query: 914 SQVSLGWEPVIPLANESEVVGYKVFYR 940
              +L W   +P      + GY + Y+
Sbjct: 946 DTATLSWG--LPKKLNGNLTGYLLQYQ 970



 Score =  120 bits (302), Expect = 5e-27
 Identities = 186/810 (22%), Positives = 309/810 (38%), Gaps = 86/810 (10%)

Query: 127  TRSAVSVREGQGVVLMC-SPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKV 185
            + S++++ +G+ ++L C +    +P++ ++ +  + P       R         L I  V
Sbjct: 262  SESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPK-----GRETKENYGKTLKIENV 316

Query: 186  QTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVK 245
               D G+Y C   N +  A            +D  +   EP      P +   + G+   
Sbjct: 317  SYQDKGNYRCTASNFLGTAT-----------HDFHVIVEEPPRWTKKPQSAVYSTGSNGI 365

Query: 246  MECFALGNPVPTITWMKVNGYIPSKARLRKSQAV----LEIPNVQLDDAGIYECRAENSR 301
            + C A G P PTI W +VNG  P          V    +   N+Q +   +Y+C A N  
Sbjct: 366  LLCEAEGEPQPTIKW-RVNGS-PVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVH 423

Query: 302  GKNSFRGQLQVYTYPHWVEKLNDTQLDS--GSPLRWECKATGKPRPTYRWLK--NGVPLS 357
            G       + V      ++  +     +  G      C+    P     W K     PL 
Sbjct: 424  GTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLE 483

Query: 358  PQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTI 417
             +      NG L I+   + DAG Y C  EN  G    +A L I  +A    ++     I
Sbjct: 484  GRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDI-RNATKLRVSPKNPRI 542

Query: 418  IVTKDQEVVIECKPQGSPKPTI--SWKKGDRAVR----ENKRIAILPDGSLRILNASKSD 471
                  E+  E K     K ++  SW K   A      E+ RI I+   +L I N +  D
Sbjct: 543  PKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRI-IIDGANLTISNVTLED 601

Query: 472  EGKYVCRGENVFGSAEIIASLSVKE----PTRIELTPKRTELTVGESIVLNCKAIHDASL 527
            +G Y C       SA  I  ++V +    P  + L+ ++       S+ L  +A  D + 
Sbjct: 602  QGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNR-----SVRLTWEAGADHNS 656

Query: 528  DVTFYWTLKGQPIDFE---EEGGHFESI-RAQASSADLMIRNILLMHAGRYGCRV----- 578
            +++ Y       ++FE   EE G +E + R Q     +++    L    RY  RV     
Sbjct: 657  NISEYI------VEFEGNKEEPGRWEELTRVQGKKTTVILP---LAPFVRYQFRVIAVNE 707

Query: 579  --QTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSP--AADNHSPISSYNLQA 634
              ++     SD  E     P   P  + V+        + W P  + + + P     L+ 
Sbjct: 708  VGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGP----GLEY 763

Query: 635  RSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRT 694
            R  +      V+   E +T      M   +  +  Y+ +V A N +G+G P   S  + +
Sbjct: 764  RVTWKPQGAPVEWEEETVTNHTLRVMTPAV--YAPYDVKVQAINQLGSG-PDPQSVTLYS 820

Query: 695  NEAVPKTAPTNVSGRSGRRHELV-IAWEPVSEEFQNGEGFGYIVAFRP-----NGTRGWK 748
             E  P TAP  + G       LV + W  V ++  +G   GY + +       +G    K
Sbjct: 821  GEDYPDTAPV-IHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPK 879

Query: 749  EKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDV 808
            E  +      +      S+   + F + V  YN+KG GP S+  +  + EG P   PT +
Sbjct: 880  EVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQ-PTFL 938

Query: 809  KATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAE----TVKTRGNESFVILT 864
            K   V      ++W   K+  G   G+ + Y    +  +  E     + T    S+  L+
Sbjct: 939  KVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWH-LS 997

Query: 865  GLEGNTLYHFTVRAYNGAGYGPPSSEVSAT 894
             L   T Y F +RA    G G P +E S+T
Sbjct: 998  NLNATTKYKFYLRACTSQGCGKPITEESST 1027



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 179/870 (20%), Positives = 321/870 (36%), Gaps = 131/870 (15%)

Query: 225  EPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKV-NGYIPSKARLRKSQ--AVLE 281
            + K++V FPF          ++EC A GNP PT +W K  N +  +  R+  S       
Sbjct: 40   QSKVQVAFPFD------EYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFR 93

Query: 282  IPNVQLDD--AGIYECRAENSRG-KNSFRGQLQVYTYPHWV-EKLNDTQLDSGSPLRWEC 337
            IPN        G Y C A N  G   S   +  V + P +  EK++  +++ G P+   C
Sbjct: 94   IPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPC 153

Query: 338  KAT-GKPRPTYRWLKNGVP-LSPQSRVEMVN-GVLMIHNVNQSDA-GMYQCLAE-NKYGA 392
                G P     W+   +  +    RV M   G L   NV + D+   Y C A   +   
Sbjct: 154  NPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRT 213

Query: 393  IYASAELKILASAPTFA------------LNQLKK----------------TIIVTKDQE 424
            I     +K+  ++   A             N +K+                +I + K + 
Sbjct: 214  IVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEI 273

Query: 425  VVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFG 484
            +++EC  +G P P + W K    + + +        +L+I N S  D+G Y C   N  G
Sbjct: 274  LLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLG 333

Query: 485  SAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEE 544
            +A     + V+EP R    P+    + G + +L C+A  +     T  W + G P+D   
Sbjct: 334  TATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEA--EGEPQPTIKWRVNGSPVDNHP 391

Query: 545  EGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVI 604
              G     R      ++   N+   H   Y C       ++   A +          +V 
Sbjct: 392  FAGDVVFPR------EISFTNLQPNHTAVYQCEASNVHGTILANANI---------DVVD 436

Query: 605  VEEITESTATLSWSPAADNHSPISSYNLQARSPFS------LGWQTVKTVPEII------ 652
            V  + ++          +N++ +  Y+      F       + WQ V+ V  +       
Sbjct: 437  VRPLIQTKD-------GENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHI 489

Query: 653  --TGDMESAMAVDLNP-----WVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN 705
               G ++     + +      WVE      A         +T  R+   N  +PK     
Sbjct: 490  YENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLE 549

Query: 706  VSGRSG----RRHELVIAWEPVSEEFQ-NGEGFGYIVAFRPNGTRG---WKEKMVTSSEA 757
            +   S      +H L ++W    E F+ NG   G I+    N T      +++ +    A
Sbjct: 550  LHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSA 609

Query: 758  SKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSE 817
               +     +  +T  +V     N       ++ V +    G    +         ++SE
Sbjct: 610  HTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNS---------NISE 660

Query: 818  ILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVR 877
             +V ++  KE  GR        W+++         + +G ++ VIL  L     Y F V 
Sbjct: 661  YIVEFEGNKEEPGR--------WEEL--------TRVQGKKTTVILP-LAPFVRYQFRVI 703

Query: 878  AYNGAGYGPPSSEVSA-TTKKSPPSQAPSNLRWE-QQGSQVSLGWEPVIPLANESEVVGY 935
            A N  G   PS       T  + P + P N+R +  Q  ++ + WEP+  +      + Y
Sbjct: 704  AVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEY 763

Query: 936  KVFYRQEG---HSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYS 992
            +V ++ +G       + +    L+ + P   A  Y ++V+A ++ G G     + +  YS
Sbjct: 764  RVTWKPQGAPVEWEEETVTNHTLRVMTPAVYA-PYDVKVQAINQLGSGPDPQSVTL--YS 820

Query: 993  GGKITSAQSTLHSLSTSSSSVTLLLALMIP 1022
            G         +H +   +S++  +    +P
Sbjct: 821  GEDYPDTAPVIHGVDVINSTLVKVTWSTVP 850


>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
          Length = 1240

 Score =  346 bits (888), Expect = 6e-95
 Identities = 265/918 (28%), Positives = 405/918 (44%), Gaps = 77/918 (8%)

Query: 32  DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPS 89
           D I+ P D+    + + CE +GNP PS+ W RN    ++  D R S+    GT +I   S
Sbjct: 50  DHIVDPRDN----ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105

Query: 90  EAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 146
             +     G YQC A N  G+ LS    LQ +    +       V V+EG  + L C+PP
Sbjct: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPP 165

Query: 147 PHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA 204
           P  P  +  W+ +     + +D R  +SQ   G+LY S V   D+ + Y C  +   T+ 
Sbjct: 166 PGLPSPVIFWMSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT 222

Query: 205 RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA----KGTTVKMECFALGNPVPTITW 260
             +    P TL+     G  E      +P    ++    +G  + +EC A G P P I W
Sbjct: 223 --IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAW 280

Query: 261 MKVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWV 319
            K  G +PS KA+       L I NV  +D+G Y C A N  G       ++V   P+W+
Sbjct: 281 YKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL 340

Query: 320 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQ 376
           ++  +  L  G   R  C+A G P+PT +W+ NG PL    P    E+    ++  +   
Sbjct: 341 DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 400

Query: 377 SDAGMYQCLAENKYGAIYASAELKILASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGS 434
           S   +YQC   N++G + A+A + +L   P      NQL + I+  + +   ++C   GS
Sbjct: 401 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGS 457

Query: 435 PKPTISW-KKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLS 493
           P PT+ W K G  +  +     +  +GSL I    K D+G Y C   N+ G AE    L 
Sbjct: 458 PIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLE 517

Query: 494 VKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIR 553
           VK+PTRI   P+      G ++ L C+  HD SL +T  W    +P+        +   R
Sbjct: 518 VKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNR 569

Query: 554 AQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLV---------------RGPPG 598
            +     L I  +     G Y C   T  D    +A L V               +G P 
Sbjct: 570 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPD 629

Query: 599 PPGIVIVEEITESTATLSWSPAADNHSPISSYNLQ-ARSPFSLG-WQTVKTVPEIITGDM 656
            P  + + ++ E +  L+W P   N+SPI+ Y +Q     F  G W      P    G +
Sbjct: 630 RPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP----GSV 685

Query: 657 ESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHEL 716
            SA+ + L+P+V Y+FRV+A N +G+  PS PS   RT+ A P++ P +V G   R++ +
Sbjct: 686 NSAV-LRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNM 744

Query: 717 VIAWEPVSEEFQNGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEV 775
            I W P++     G    YIV +R   TR  W    V  S      Y     P   P+E+
Sbjct: 745 EITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSR-----YVVGQTPVYVPYEI 799

Query: 776 KVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGF 835
           +V   N+ G GP  + V+  S E  PS AP   +    ++  I + W H +     P G 
Sbjct: 800 RVQAENDFGKGPEPESVIGYSGEDLPS-APRRFRVRQPNLETINLEWDHPE----HPNGI 854

Query: 836 EVGYWKDMEQEDTAETVKT-----RGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSE 890
            +GY       +  +  K        N++   +   +  + Y FT+ A    G G   +E
Sbjct: 855 MIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTE 914

Query: 891 VS-ATTKKSPPSQAPSNL 907
            S A   ++ P+ AP  L
Sbjct: 915 ESPAPPNEATPTAAPPTL 932



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 66/305 (21%), Positives = 124/305 (40%), Gaps = 40/305 (13%)

Query: 320 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN----GVPLSPQSRVEMVNGVLMIH--- 372
           +   D  +D    +  EC+A G P P++ W +N     +   P+  +   +G L+I    
Sbjct: 46  QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105

Query: 373 -NVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK- 430
               +   G YQC A NK+G   ++     ++ +P +    L   ++V +   + ++C  
Sbjct: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNP 164

Query: 431 PQGSPKPTISWKKGD-RAVRENKRIAILPDGSLRILNASKSD-EGKYVCRG--------- 479
           P G P P I W       + ++KR++   +G L   N    D +  Y C           
Sbjct: 165 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 224

Query: 480 -ENVFGSAEIIASLSVKEPTRIELTPKRTE----LTVGESIVLNCKAIHDASLDVTFYWT 534
            +N F + +++ +  V E T   + P+ T     +  G  ++L C A    + D+ +Y  
Sbjct: 225 QKNPF-TLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWY-- 281

Query: 535 LKGQPIDFEEEGGHFESIRAQASSAD--LMIRNILLMHAGRYGCRVQTTADSVSDEAELL 592
                    ++GG   S +A+  + +  L I N+    +G Y C       S+     + 
Sbjct: 282 ---------KKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 332

Query: 593 VRGPP 597
           V+  P
Sbjct: 333 VKAAP 337



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 38/178 (21%), Positives = 76/178 (42%), Gaps = 21/178 (11%)

Query: 402 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 459
           L   PT      K  I+  +D  ++IEC+ +G+P P+  W +  R   + ++ R+++   
Sbjct: 37  LTQPPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95

Query: 460 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 510
               +++       +  EG+Y C   N FG+A  +++    + ++  L PK       + 
Sbjct: 96  SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA--LSNRIRLQVSKSPLWPKENLDPVVVQ 153

Query: 511 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL 568
            G  + L C         V F+ +   +PI  ++         +Q  + DL   N++L
Sbjct: 154 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR-------VSQGHNGDLYFSNVML 204


>gi|222352127 sidekick 2 [Homo sapiens]
          Length = 2172

 Score =  275 bits (703), Expect = 2e-73
 Identities = 263/1007 (26%), Positives = 415/1007 (41%), Gaps = 59/1007 (5%)

Query: 5   WKLMLFLSVTMCLSESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRN 64
           W L+    +    ++  D  P F  EP  +      +  ++ L C   G+    ++WL N
Sbjct: 7   WTLLALHQIRAARAQD-DVSPYFKTEP--VRTQVHLEGNRLVLTCMAEGSWPLEFKWLHN 63

Query: 65  GTEIDLES-DYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNF 123
             E+   S +YRY +           +   +G Y+C+  N +G++L R+  +Q AY+G+F
Sbjct: 64  NRELTKFSLEYRYMITS--------LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSF 115

Query: 124 SGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYIS 183
               +   SV  G+  V+        P+   +W F +    +   SR  I+ E   + +S
Sbjct: 116 EEGEKHQ-SVSHGEAAVIRAPRIASFPQPQVTW-FRDGRK-IPPSSRIAITLENTLVILS 172

Query: 184 KVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGE-YEPKIEVHFPFTVTAAKGT 242
            V   D G Y     N        S P  LT+ N G   +   P I +    T   A  +
Sbjct: 173 TV-APDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTS 231

Query: 243 TVKMECFALGNPVPT--ITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRA--E 298
            V +EC A   P+    I W K +G + S   +      L IPN    DAG YEC A   
Sbjct: 232 EVTLECVANARPLIKLHIIWKK-DGVLLSGG-ISDHNRRLTIPNPTGSDAGYYECEAVLR 289

Query: 299 NSRGKNSFRGQ-LQVYTYPHWV-EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG--V 354
           +S   +  RG  L V   P +V E       +    +   C+A G P P+  W K+   V
Sbjct: 290 SSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVV 349

Query: 355 PLSPQSRVEMVN-GVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQL 413
            +   +R    N G L I  +   D GM+QC A N  G +  S  L + + AP      L
Sbjct: 350 EVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPL 409

Query: 414 KKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENK----RIAILPDGSLRILNASK 469
             T+I      VV+ C+  G+P+P I+W+KG+R +        R   L  GSL I     
Sbjct: 410 DSTVI--DGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHI 467

Query: 470 SDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDV 529
           SD G Y C   N  G  E  A L V   TRI   P+   +  G    + C   HD  + +
Sbjct: 468 SDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTI 527

Query: 530 TFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEA 589
            + W   G  +  E        IR   + + L I        G Y CRV +   + S  A
Sbjct: 528 RYIWEKDGATLGTESH----PRIRLDRNGS-LHISQTWSGDIGTYTCRVISAGGNDSRSA 582

Query: 590 ELLVRGPPGPPG--IVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKT 647
            L VR  P  P   +  +  +      L+W+   D +SP+  Y L+  S  +  W  +  
Sbjct: 583 HLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEM-SENNAPWTVLLA 641

Query: 648 VPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVS 707
               +     S     L P   Y+FR+ A N +G G  S  +  +   E  P   P NV 
Sbjct: 642 S---VDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVI 698

Query: 708 GRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDES 766
                   ++I W+P  E  QNG   GYI+ +   G   G++ K +T ++ +  +  D  
Sbjct: 699 ASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLI 758

Query: 767 VPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK 826
           +   T +E++V  YN+ G G +S  V   + +G P+  P +V A + + + I   W    
Sbjct: 759 I--WTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPS 816

Query: 827 ESL--GRPQGFEVGYWK-DMEQEDTAETVKTRGNESFVI--LTGLEGNTLYHFTVRAYNG 881
                G  QG+++  W+ + E+E T  T +    +S  +  ++GL+  T Y  +V  +  
Sbjct: 817 PQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTT 876

Query: 882 AGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQ 941
            G GP S+     T +  P         E   + + + W+   P      + GY++ + +
Sbjct: 877 PGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQE--PGEKNGILTGYRISWEE 934

Query: 942 EGHSNSQV---IETQKLQ-AVVPLPDAGVYIIEVRAYSEGGDGTASS 984
              +N++V   +    L+  V  L     Y IEV A +  G G  S+
Sbjct: 935 YNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSA 981



 Score =  142 bits (357), Expect = 2e-33
 Identities = 114/384 (29%), Positives = 185/384 (48%), Gaps = 38/384 (9%)

Query: 587  DEAELLV-----RGPPGPPGIVIV--EEITESTATLSWSPAADNHSPISSYNLQARSPFS 639
            + AE LV     R  P PP   +V  E++   +  LSW P +D  SP+  Y +Q R   S
Sbjct: 1385 EAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPS 1444

Query: 640  LGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVP 699
              W         ++ +  S +   L P+  Y+FRV ATN IG  + S  S  + T +A P
Sbjct: 1445 GRWALHSAS---VSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAP 1501

Query: 700  KTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRP---NGTRGWKEKMVTSSE 756
              APT +S        ++I W+P +E+  NG   G+ + +R     G RG+  + + +  
Sbjct: 1502 DEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPG 1561

Query: 757  A------SKFIYRDESVPPLTP-----------FEVKVGVYNNKGDGPFSQIVVICSAEG 799
            A      S +  R+ S P LT            +E+++ VYN  G+GP S    +   E 
Sbjct: 1562 ATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEA 1621

Query: 800  EPSAAPTDVKATSVSVSEILVAWK--HIKESLGRPQGFEVGYWKDMEQEDTAETVKTRG- 856
             P+AAP +V     + +++ V W+   +    G  QG+++ +W + ++ +  E VKT   
Sbjct: 1622 VPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFW-EAQRGNLTERVKTLFL 1680

Query: 857  NESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRW-EQQGSQ 915
             E+ V L  L G T Y  +V A+N AG GP S+     T+++ PS APS++++ E   + 
Sbjct: 1681 AENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPS-APSSVKFSELTTTS 1739

Query: 916  VSLGWEPVIPLANESEVVGYKVFY 939
            V++ WE   P      + GY++ Y
Sbjct: 1740 VNVSWE--APQFPNGILEGYRLVY 1761



 Score =  139 bits (351), Expect = 1e-32
 Identities = 118/408 (28%), Positives = 180/408 (44%), Gaps = 24/408 (5%)

Query: 597  PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG-D 655
            PGPP  + +  I   + TL + P  D  + IS + ++A+       +    + ++    D
Sbjct: 993  PGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPD 1052

Query: 656  MESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHE 715
              S    DLNP+  Y FR+   N +GT  PS PSR I+T +A P  AP NVS R+     
Sbjct: 1053 ARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETS 1112

Query: 716  LVIAWEPVSEEFQNG--EGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPF 773
            L + W P+ E   NG  E  GY + +  +   G     V      +  Y  E +   T +
Sbjct: 1113 LWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVER-DYTIEDLEEWTEY 1171

Query: 774  EVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKES--LGR 831
             V+V  +N  G GP+SQ VV  + E  PS+ PT+V A + + S +LV W  + E+   G 
Sbjct: 1172 RVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGL 1231

Query: 832  PQGFEVGYWKDMEQEDTAETVKTRGNES-FVILTGLEGNTLYHFTVRAYNGAGYGPPS-S 889
              G++V Y K+ + +         GN S    LTGL    LY   V A+   G G PS  
Sbjct: 1232 VLGYKVMY-KEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHP 1290

Query: 890  EVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQV 949
             +   T    P      L  E + + V L W+P  P A    ++ Y++ +R     N+  
Sbjct: 1291 PILERTLDDVPGPPMGILFPEVRTTSVRLIWQP--PAAPNGIILAYQITHR----LNTTT 1344

Query: 950  IETQKLQAVVP---------LPDAGVYIIEVRAYSEGGDGTASSQIRV 988
              T  ++ + P         L    VY+  + A +  G G A+  + V
Sbjct: 1345 ANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVV 1392



 Score =  138 bits (347), Expect = 3e-32
 Identities = 235/1057 (22%), Positives = 403/1057 (38%), Gaps = 115/1057 (10%)

Query: 24   GPVFVQEPDDIIFPTDSD----EKKVALNCEVRGNPVPSYR--WLRNGTEIDLE-SDYRY 76
            GP     P  II P ++       +V L C     P+      W ++G  +    SD+  
Sbjct: 208  GPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNR 267

Query: 77   SLIDGTFIISNPSEAKDSGHYQCLATNTVGSILS--REATLQFAYLGNFSGRTRSAVSVR 134
             L      I NP+   D+G+Y+C A     S+ S  R A L       F       ++  
Sbjct: 268  RLT-----IPNPT-GSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAE 321

Query: 135  EGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYI 194
              + V + C      P  I +W + +      E   RF  +  G L IS +   D G + 
Sbjct: 322  MEKVVDIPCQAKGVPPPSI-TW-YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQ 379

Query: 195  CLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNP 254
            C  +N     +  +     ++  +   G          P   T   G +V + C   G P
Sbjct: 380  CFARNAAGEVQTSTYLAVTSIAPNITRG----------PLDSTVIDGMSVVLACETSGAP 429

Query: 255  VPTITWMK-----VNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQ 309
             P ITW K      +G +            L I    + DAG Y C A NSRG +     
Sbjct: 430  RPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASAD 489

Query: 310  LQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYR--WLKNGVPLSPQSRVEMV-- 365
            L V+      +   D  +  G+     C  T  PR T R  W K+G  L  +S   +   
Sbjct: 490  LVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLD 549

Query: 366  -NGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI--LASAPTFALNQL----KKTII 418
             NG L I      D G Y C   +  G    SA L++  L  AP   +  L    ++ I 
Sbjct: 550  RNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAIN 609

Query: 419  VTKDQ---------EVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASK 469
            +T  +           ++E     +P   +      +A     +  ++P  S +    + 
Sbjct: 610  LTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVK-GLVPARSYQFRLCAV 668

Query: 470  SDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVG---ESIVLNCKAIHDAS 526
            +D GK        F       SL  + PT     P +  +  G   +SI++  +   ++ 
Sbjct: 669  NDVGK------GQFSKDTERVSLPEEPPT----APPQNVIASGRTNQSIMIQWQPPPESH 718

Query: 527  LD-----VTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTT 581
             +         + L G P+ ++     F++I   A   +L++ ++++            +
Sbjct: 719  QNGILKGYIIRYCLAGLPVGYQ-----FKNI-TDADVNNLLLEDLIIWTNYEIEVAAYNS 772

Query: 582  ADS---VSDEAELLVRGPPG-PPGIVIVEEITESTATLSWS-PAADNHSPISS-YNLQAR 635
            A      S   E  ++G P  PPG V  E    +T   +W+ P+    + I+  Y L A 
Sbjct: 773  AGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAW 832

Query: 636  SPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTN 695
             P      T+ T        +       L  + EY   V+     G G  STP +++RT+
Sbjct: 833  EPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTP-QLVRTH 891

Query: 696  EAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSS 755
            E VP     ++S        L ++W+   E+  NG   GY ++        W+E   T++
Sbjct: 892  EDVPGPVG-HLSFSEILDTSLKVSWQEPGEK--NGILTGYRIS--------WEEYNRTNT 940

Query: 756  EASKFI------YRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVK 809
              + ++      YR   +  LT + ++V    +KG G  S   +      E    PT++ 
Sbjct: 941  RVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLG 1000

Query: 810  ATSVSVSEILVAWK---HIKESLGR-PQGFEVGYWKDMEQEDTAETVKTRGNESFVILTG 865
             +++    + + ++     K S+ R     +VG   + E+      +    +   + +  
Sbjct: 1001 ISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPD 1060

Query: 866  LEGNTLYHFTVRAYNGAGYGPPSS-EVSATTKKSPPSQAPSNLRWEQQG-SQVSLGWEPV 923
            L   T Y F +R  N  G  PPS       T ++PP  AP+N+       + + L W P+
Sbjct: 1061 LNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPL 1120

Query: 924  --IPLANESEVVGYKVFY-RQEGHSN--SQVIE--TQKLQAVVPLPDAGVYIIEVRAYSE 976
              +      E VGYK+ Y R +GH    S V++   ++   +  L +   Y ++V+A++ 
Sbjct: 1121 PEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNA 1180

Query: 977  GGDGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSV 1013
             G G  S  + V        +S  + + +L+T+SSS+
Sbjct: 1181 IGSGPWSQTV-VGRTRESVPSSGPTNVSALATTSSSM 1216



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 100/453 (22%), Positives = 179/453 (39%), Gaps = 45/453 (9%)

Query: 597  PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVP-EIITGD 655
            PGPP  ++  E+  ++  L W P A  +  I +Y +  R    L   T  T   E++   
Sbjct: 1301 PGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHR----LNTTTANTATVEVLAPS 1356

Query: 656  MESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN---VSGRSGR 712
                 A  L P   Y FR+ A    G G+ +    ++ T E   +  P +   V     R
Sbjct: 1357 ARQYTATGLKPESVYLFRITAQTRKGWGEAA--EALVVTTEKRDRPQPPSRPMVQQEDVR 1414

Query: 713  RHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP 772
               ++++WEP S+       +       P+G        V S  AS FI   + + P T 
Sbjct: 1415 ARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASV-SHNASSFIV--DRLKPFTS 1471

Query: 773  FEVKVGVYNNKGDGPFSQ-IVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL-- 829
            ++ +V   N+ GD  FS+    + + +  P  APT +  T  + + +L+ W+   E    
Sbjct: 1472 YKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKIN 1531

Query: 830  GRPQGFEVGY----------------------WKDMEQEDTAETVKTRGNESFVILTGLE 867
            G   GF + Y                      W ++    +   + +R + +   L  L 
Sbjct: 1532 GILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNL-SRPSLTQYELDNLN 1590

Query: 868  GNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWE-QQGSQVSLGWEPVIPL 926
             +  Y   +  YN  G GP S        ++ P+ AP N+       +Q+ + WEP    
Sbjct: 1591 KHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLD 1650

Query: 927  ANESEVVGYKVFY--RQEGHSNSQVIETQKLQAVVPLPDA---GVYIIEVRAYSEGGDGT 981
            +   ++ GYK+++   Q G+   +V      +  V L +      Y++ V A++  GDG 
Sbjct: 1651 SQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP 1710

Query: 982  ASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVT 1014
             S+  +  +        +      L+T+S +V+
Sbjct: 1711 RSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVS 1743



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 82/349 (23%), Positives = 144/349 (41%), Gaps = 22/349 (6%)

Query: 586  SDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTV 645
            S + + L   P   P  V +   +E++  L W P      P   YN    +P S+G++  
Sbjct: 1086 SRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPL-----PEMEYN---GNPESVGYKIK 1137

Query: 646  --------KTVPEIITGDMESAMAV-DLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNE 696
                    KT+  ++   +E    + DL  W EY  +V A N IG+G P + + + RT E
Sbjct: 1138 YSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSG-PWSQTVVGRTRE 1196

Query: 697  AVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSE 756
            +VP + PTNVS  +     +++ W  V E  +NG   GY V ++   +       +    
Sbjct: 1197 SVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGN 1256

Query: 757  ASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVS 816
            +S+       +     +EV+V  +   GDG  S   ++     +    P  +    V  +
Sbjct: 1257 SSRSAQLT-GLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTT 1315

Query: 817  EILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTV 876
             + + W+      G    +++ +  +    +TA       +      TGL+  ++Y F +
Sbjct: 1316 SVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRI 1375

Query: 877  RAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQ---GSQVSLGWEP 922
             A    G+G  +  +  TT+K    Q PS    +Q+      V L WEP
Sbjct: 1376 TAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEP 1424



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 41/132 (31%), Positives = 65/132 (49%), Gaps = 9/132 (6%)

Query: 573  RYGCRVQTTADSVSDEAELLV---RGPPGPPGIVIVEEITESTATLSWSPAADNHSPISS 629
            R+  R +T       EA +      G PGPPG+ I+   + + A + WS       PI+ 
Sbjct: 1798 RFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIA-IHWSSGDPGKGPITR 1856

Query: 630  YNLQARSPFSLGWQT-VKTVPEIITGDMESAMAVD-LNPWVEYEFRVVATNPIGTGDPST 687
            Y ++AR      W   +K +P+ ++       ++D L P V Y+FRV+A N  G G PS+
Sbjct: 1857 YVIEARPSDEGLWDILIKDIPKEVSS---YTFSMDILKPGVSYDFRVIAVNDYGFGTPSS 1913

Query: 688  PSRMIRTNEAVP 699
            PS+ +   +A P
Sbjct: 1914 PSQSVPAQKANP 1925



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 74/324 (22%), Positives = 121/324 (37%), Gaps = 40/324 (12%)

Query: 596  PPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQT-----VKTVPE 650
            P   P  V+V   T +   ++W P      P+ S N   +      W+       + V  
Sbjct: 1623 PTAAPRNVVVHGATATQLDVTWEPP-----PLDSQNGDIQGYKIYFWEAQRGNLTERVKT 1677

Query: 651  IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRS 710
            +   +  S    +L  +  Y   V A N  G G  STP++  +T +A P +AP++V    
Sbjct: 1678 LFLAE-NSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQG-QTQQAAP-SAPSSVKFSE 1734

Query: 711  GRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASK----FIYRDES 766
                 + ++WE  + +F NG   GY + + P        K+VT             +D +
Sbjct: 1735 LTTTSVNVSWE--APQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLA 1792

Query: 767  VPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK 826
                  F ++   +     GP  +  V  +  GE +  P  V       S I + W    
Sbjct: 1793 EGVTYRFRIRAKTFTY---GPEIEANVT-TGPGEGAPGPPGVPIIVRYSSAIAIHWSSGD 1848

Query: 827  ESLG---------RPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVR 877
               G         RP   + G W D+  +D  + V +      ++  G+     Y F V 
Sbjct: 1849 PGKGPITRYVIEARPS--DEGLW-DILIKDIPKEVSSYTFSMDILKPGVS----YDFRVI 1901

Query: 878  AYNGAGYGPPSS-EVSATTKKSPP 900
            A N  G+G PSS   S   +K+ P
Sbjct: 1902 AVNDYGFGTPSSPSQSVPAQKANP 1925


>gi|119220552 sidekick 1 [Homo sapiens]
          Length = 2213

 Score =  274 bits (700), Expect = 4e-73
 Identities = 269/1045 (25%), Positives = 436/1045 (41%), Gaps = 74/1045 (7%)

Query: 5    WKLM-LFLSVTMCLSESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLR 63
            W L+ L L +   L++  D  P F  EP   +     +  ++ L C   G+    ++W+R
Sbjct: 84   WALLALQLHLLRALAQD-DVAPYFKTEPG--LPQIHLEGNRLVLTCLAEGSWPLEFKWMR 140

Query: 64   NGTEIDL-ESDYRYSLIDGTFIISNPSEAK-DSGHYQCLATNTVGSILSREATLQFAYLG 121
            + +E+    S+Y+Y +         PS  K D+G Y+C+  N +G++L R++ +Q AY+G
Sbjct: 141  DDSELTTYSSEYKYII---------PSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMG 191

Query: 122  NFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLY 181
            +F   T    +V +G+  +L   P    P    +W F E    +   S R        L 
Sbjct: 192  SFMD-TDQRKTVSQGRAAILNLLPITSYPRPQVTW-FREGHKIIP--SNRIAITLENQLV 247

Query: 182  ISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRND-GVMGEYEPKIEVHFPFTVTAAK 240
            I    TSD G+Y     N        SP   L++  D G      P I V        A 
Sbjct: 248  ILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAG 307

Query: 241  GTTVKMECFALGNPVP--TITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAE 298
             +   +EC A   PV   ++TW K NG +   + L      L I N    D G Y C A 
Sbjct: 308  SSETTLECIASARPVEDLSVTW-KRNG-VRITSGLHSFGRRLTISNPTSADTGPYVCEAA 365

Query: 299  ---NSRGKNSFRGQLQVYTYPHWV-EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGV 354
               ++         L +   P++  E  +    +    +   C+A G P PT +W K+ +
Sbjct: 366  LPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAI 425

Query: 355  PLS----PQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFAL 410
             +S    P+ +V + +G L I  +   D+G++QC A N+ G I     L +   AP F  
Sbjct: 426  SISRLQNPRYKV-LASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQ 484

Query: 411  NQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENK----RIAILPDGSLRILN 466
              +  T  VT     ++ C+  G+PKP I+WK+ +  +        R  +L  G L+I  
Sbjct: 485  RPVDTT--VTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAP 542

Query: 467  ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDAS 526
                D G Y C   N  GS    A+L+V   T I   P+   +  G +  L+C A HD  
Sbjct: 543  VFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPR 602

Query: 527  LDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVS 586
            + + + W      +          S         L+I        G Y C + +   + S
Sbjct: 603  VSLRYVWKKDNVALTPSST-----SRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDS 657

Query: 587  DEAEL-LVRGPPGPPGIVIVEEITESTAT-LSWSPAADNHSPISSYNLQARSPFSLGWQT 644
              A L ++  P  P  +++    + S A  LSW    D +SPI  Y ++     S     
Sbjct: 658  RMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVH 717

Query: 645  VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPT 704
            +  V   +TG   S     L P   Y+FRV A N +G G  S  +  +   E  P   P 
Sbjct: 718  LSNVGPEMTGVTVSG----LTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPK 773

Query: 705  NVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRG-WKEKMVTSSEASKFIYR 763
            N+         +++ W+P  E   NG   GYI+ +R  G  G ++++ +TS E +  +  
Sbjct: 774  NIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVT 833

Query: 764  DESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWK 823
            D  +   T +E++V  YN  G G FS+ V   + +G P+A P +V+  +V+ + I   W 
Sbjct: 834  DLII--WTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWN 891

Query: 824  HIKESL--GRPQGFEVGYWKDMEQEDTAETVKTRGNESFVI----LTGLEGNTLYHFTVR 877
               +    G  QG+++  W     E  A TV T   +   +    +T L+  T Y  +V 
Sbjct: 892  PPPQQFINGINQGYKLLAWPADAPE--AVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVL 949

Query: 878  AYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKV 937
             +   G GPPS+     T++  P         E   + + + W+   PL     + GY++
Sbjct: 950  CFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQE--PLEKNGIITGYQI 1007

Query: 938  FYRQEGHSNSQVIET-------QKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPS 990
             +   G ++S++  T        K+Q +  L     Y I+V A +  G G  +S   + S
Sbjct: 1008 SWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLT---TYTIDVAAVTAVGTGLVTSS-TISS 1063

Query: 991  YSGGKITSAQSTLHSLSTSSSSVTL 1015
                 +  A S L   + S  S TL
Sbjct: 1064 GVPPDLPGAPSNLVISNISPRSATL 1088



 Score =  126 bits (316), Expect = 1e-28
 Identities = 110/407 (27%), Positives = 186/407 (45%), Gaps = 38/407 (9%)

Query: 597  PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLG----WQTVKTVPEII 652
            PG P  +++  I+  +ATL + P  D  + IS + ++ +   ++G    W T+    E  
Sbjct: 1070 PGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVG-AIGDEEEWVTL--YEEEN 1126

Query: 653  TGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGR 712
              D +     +L P+  Y FR+   N +G    S  SR+I+T +A P  APT+V+ R+  
Sbjct: 1127 EPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTAS 1186

Query: 713  RHELVIAWEPVSEEFQNG--EGFGYIVAFRPNGTRGWKEKMVTSSEA---SKFIYRDESV 767
               L + W P+ +   NG  E  GY + +       W+  + +S+ A   S  + R+ ++
Sbjct: 1187 ETSLRLRWVPLPDSQYNGNPESVGYRIKY-------WRSDLQSSAVAQVVSDRLEREFTI 1239

Query: 768  PPL---TPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKH 824
              L     +E+++  +N  G GP+S++V   + E  PSAAP +V A +VS ++IL+ W  
Sbjct: 1240 EELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTS 1299

Query: 825  IKESLGRPQGFEVGY-----WKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAY 879
            + E      G  +GY      KD++ E  +  V+    +S  +L GL    LY   V A+
Sbjct: 1300 VPEQ--DQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQS-ALLAGLRKFVLYELQVLAF 1356

Query: 880  NGAGYGPPSSEVSATTKKSPPSQAPSNLRW-EQQGSQVSLGWEPVIPLANESEVVGYKVF 938
               G G PS+ +     K      P  L + E + + V + W+P  P      ++GY++ 
Sbjct: 1357 TRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQP--PEEPNGIILGYQIA 1414

Query: 939  YRQEGHS-----NSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDG 980
            YR    S       +V  T +      L     YI  + A +  G G
Sbjct: 1415 YRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWG 1461



 Score =  124 bits (312), Expect = 3e-28
 Identities = 102/372 (27%), Positives = 166/372 (44%), Gaps = 32/372 (8%)

Query: 594  RGPPGPPGIVIVE--EITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEI 651
            R  P PP  ++V   E+T  +  L W P +D  SPI  + +Q R      WQT  +    
Sbjct: 1474 RERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSS--- 1530

Query: 652  ITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSG 711
            I+ +  + +   L P+  Y+ R+ ATN IG  D S+ +  + T + VP   P +VS    
Sbjct: 1531 ISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH 1590

Query: 712  RRHELVIAWEPVSEEFQNGEGFGYIVAFRP------NGTRGWKEKM-------VTSSEAS 758
                ++I W+P  +E  NG   GY + +R       +GT     K        +T+  + 
Sbjct: 1591 TTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSF 1650

Query: 759  KFIYRDES--------VPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKA 810
            K +    +        +     +EV +  YN  G+ P S  V +   E  P+ AP +V+ 
Sbjct: 1651 KTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQV 1710

Query: 811  TSVSVSEILVAWKHI--KESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEG 868
            T ++ S++ V W     +   G  QG+++ YW+   Q +T +       E  V L  L  
Sbjct: 1711 TPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTS 1770

Query: 869  NTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRW-EQQGSQVSLGWEPVIPLA 927
            +T Y  ++ A+N AG GP S      T ++ P  APS L + E   + +++ W    P A
Sbjct: 1771 HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPG-APSFLAFSEITSTTLNVSWGE--PAA 1827

Query: 928  NESEVVGYKVFY 939
                + GY+V Y
Sbjct: 1828 ANGILQGYRVVY 1839



 Score =  102 bits (255), Expect = 1e-21
 Identities = 105/427 (24%), Positives = 178/427 (41%), Gaps = 54/427 (12%)

Query: 597  PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDM 656
            PGPP  ++  E+  ++  + W P  + +  I  Y +  R   S    T  TV   +   +
Sbjct: 1378 PGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP-HTFTTVE--VGATV 1434

Query: 657  ESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN---VSGRSGRR 713
                A DL P   Y FR+ A    G G+P   +  + T E   + AP     V       
Sbjct: 1435 RQFTATDLAPESAYIFRLSAKTRQGWGEPLEAT--VITTEKRERPAPPRELLVPQAEVTA 1492

Query: 714  HELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPF 773
              L + W P S+       F   V   P G   W+    + S  +     D  + P T +
Sbjct: 1493 RSLRLQWVPGSDGASPIRYFTMQVRELPRGE--WQTYSSSISHEATACVVDR-LRPFTSY 1549

Query: 774  EVKVGVYNNKGDGPFS-QIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK-ESL-G 830
            ++++   N+ GD  FS +   + + +  P   P  V AT  + S +L+ W+  + ESL G
Sbjct: 1550 KLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNG 1609

Query: 831  RPQGFEVGYWKDMEQE-----------------------DTAETVKTRGNESFVILTGLE 867
              QG+ + Y++++E E                        + +TV +    +   LT L+
Sbjct: 1610 LLQGYRI-YYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLK 1668

Query: 868  GNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQ-QGSQVSLGWEPVIPL 926
                Y   + AYN  G  P S+ V     ++ P+ AP N++      SQ+ + W+P  P 
Sbjct: 1669 KYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPE 1728

Query: 927  ANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGV----------YIIEVRAYSE 976
            +    + GYK++Y +    N    ET+K++ V+ LP+  V          Y++ + A++ 
Sbjct: 1729 SQNGNIQGYKIYYWEADSQN----ETEKMK-VLFLPEPVVRLKNLTSHTKYLVSISAFNA 1783

Query: 977  GGDGTAS 983
             GDG  S
Sbjct: 1784 AGDGPKS 1790



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 104/442 (23%), Positives = 174/442 (39%), Gaps = 50/442 (11%)

Query: 596  PPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTV--------KT 647
            P   P  V V   +E++  L W P  D     S YN    +P S+G++            
Sbjct: 1173 PDVAPTSVTVRTASETSLRLRWVPLPD-----SQYN---GNPESVGYRIKYWRSDLQSSA 1224

Query: 648  VPEIITGDMESAMAVD-LNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNV 706
            V ++++  +E    ++ L  W+EYE ++ A N +G G  S   R  RT E+VP  AP NV
Sbjct: 1225 VAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRG-RTRESVPSAAPENV 1283

Query: 707  SGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNG---------TRGWKEKMVTSSEA 757
            S  +    ++++ W  V E+ QNG   GY + FR             RG   +    +  
Sbjct: 1284 SAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGL 1343

Query: 758  SKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSE 817
             KF+           +E++V  +   G+G  S  +++   + +    P  +    V ++ 
Sbjct: 1344 RKFVL----------YELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTS 1393

Query: 818  ILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVR 877
            + + W+  +E  G   G+++ Y        T  TV+          T L   + Y F + 
Sbjct: 1394 VRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLS 1453

Query: 878  AYNGAGYGPPSSEVSATTKKSPPSQAPSNL---RWEQQGSQVSLGWEPVIPLANESEVVG 934
            A    G+G P      TT+K      P  L   + E     + L W P    A+      
Sbjct: 1454 AKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFT 1513

Query: 935  YKV--FYRQEGHSNSQVIETQKLQAVVP-LPDAGVYIIEVRAYSEGGDGTASSQIR---- 987
             +V    R E  + S  I  +    VV  L     Y + ++A ++ GD   SS+      
Sbjct: 1514 MQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTT 1573

Query: 988  ---VPSYSGGKITSAQSTLHSL 1006
               VP    G +++   T  S+
Sbjct: 1574 LQDVPGEPPGSVSATPHTTSSV 1595



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 6/107 (5%)

Query: 595  GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQT-VKTVPEIIT 653
            G PG P  V+V + + S  TL W+      +P + Y ++AR      W   VK +P   T
Sbjct: 1901 GSPGSPRDVLVTK-SASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSAT 1959

Query: 654  GDMESAMAVD-LNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVP 699
                  +++D L   V YEFRVVA N  G G+PS PS  +      P
Sbjct: 1960 S---YTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 87/337 (25%), Positives = 127/337 (37%), Gaps = 52/337 (15%)

Query: 596  PPGPPGIVIVEEITESTATLSWSPAA--DNHSPISSYNL---QARSPFSLGWQTVKTVPE 650
            P   P  V V  +T S   ++W P      +  I  Y +   +A S        V  +PE
Sbjct: 1701 PAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPE 1760

Query: 651  IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRS 710
             +          +L    +Y   + A N  G G  S P +  RT++A P  AP+ ++   
Sbjct: 1761 PVV------RLKNLTSHTKYLVSISAFNAAGDGPKSDPQQG-RTHQAAPG-APSFLAFSE 1812

Query: 711  GRRHELVIAW-EPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPP 769
                 L ++W EP +    NG   GY V + P        K+VT      +  R   V  
Sbjct: 1813 ITSTTLNVSWGEPAAA---NGILQGYRVVYEPLAPVQGVSKVVTVEVRGNW-QRWLKVRD 1868

Query: 770  LTP-----FEVKVGVYNNKGDGPFSQIVVICS-AEGEPSAAPTDVKATSVSVSEILVAWK 823
            LT      F V+         GP  Q  +    AEG P + P DV  T  S SE+ + W 
Sbjct: 1869 LTKGVTYFFRVQARTITY---GPELQANITAGPAEGSPGS-PRDVLVTK-SASELTLQWT 1923

Query: 824  -----------HIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLY 872
                       ++ E+    +G    + KD+ +  T+ T+          L  L     Y
Sbjct: 1924 EGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLS---------LDKLRQGVTY 1974

Query: 873  HFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRW 909
             F V A N AGYG PS   + +T  S   +AP    W
Sbjct: 1975 EFRVVAVNEAGYGEPS---NPSTAVSAQVEAPFYEEW 2008


>gi|28373124 contactin 4 isoform b precursor [Homo sapiens]
          Length = 282

 Score =  249 bits (636), Expect = 9e-66
 Identities = 125/275 (45%), Positives = 180/275 (65%), Gaps = 7/275 (2%)

Query: 747  WKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPT 806
            W   ++ S++AS++++R+ESV P +PFEVKVGV+NNKG+GPFS   V+ SAE EP+  P 
Sbjct: 3    WMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPA 62

Query: 807  DVKATSVSVSEILVAWKH-IKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTG 865
             + A S+S ++I V W   ++++ GR QG+EV YW+  ++E+ A  ++T GN++   +T 
Sbjct: 63   SIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITN 122

Query: 866  LEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIP 925
            L+G+ LYH  V+AYN AG GP S+ V+ TT+K PPSQ P N+ W    S++ L W+ V  
Sbjct: 123  LKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKA 182

Query: 926  LANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQ 985
            L NESEV GYKV YR    S++ VIET K    + LP    YIIE++ +S+GGDG++S Q
Sbjct: 183  LDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQ 242

Query: 986  IRVPSYS------GGKITSAQSTLHSLSTSSSSVT 1014
            IR+P  S       G  TS   TL ++ST   S+T
Sbjct: 243  IRIPKISNAYARGSGASTSNACTLSAISTIMISLT 277


>gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
          Length = 613

 Score =  245 bits (626), Expect = 1e-64
 Identities = 179/617 (29%), Positives = 270/617 (43%), Gaps = 46/617 (7%)

Query: 5   WKLMLFLSVTMCLSESVDYGPVFVQEP--------DDIIFPTDSDEKKVALNCEVRGNPV 56
           W    FL   + L  +++      Q P        D I+ P D+    + + CE +GNP 
Sbjct: 9   WVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDN----ILIECEAKGNPA 64

Query: 57  PSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPSEAKDS---GHYQCLATNTVGSILSR 111
           PS+ W RN    ++  D R S+    GT +I   S  +     G YQC A N  G+ LS 
Sbjct: 65  PSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN 124

Query: 112 EATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRR 171
              LQ +    +       V V+EG  + L C+PPP  P  +  W+ +     + +D R 
Sbjct: 125 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEP-ITQDKR- 182

Query: 172 FISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIE 229
            +SQ   G+LY S V   D+ + Y C  +   T+   +    P TL+     G  E    
Sbjct: 183 -VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT--IQQKNPFTLKVLTTRGVAERTPS 239

Query: 230 VHFPFTVTAA----KGTTVKMECFALGNPVPTITWMKVNGYIPS-KARLRKSQAVLEIPN 284
             +P    ++    +G  + +EC A G P P I W K  G +PS KA+       L I N
Sbjct: 240 FMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITN 299

Query: 285 VQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPR 344
           V  +D+G Y C A N  G       ++V   P+W+++  +  L  G   R  C+A G P+
Sbjct: 300 VSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPK 359

Query: 345 PTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI 401
           PT +W+ NG PL    P    E+    ++  +   S   +YQC   N++G + A+A + +
Sbjct: 360 PTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSV 419

Query: 402 LASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGSPKPTISW-KKGDRAVRENKRIAILP 458
           L   P      NQL + I+  + +   ++C   GSP PT+ W K G  +  +     +  
Sbjct: 420 LDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYE 476

Query: 459 DGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLN 518
           +GSL I    K D+G Y C   N+ G AE    L VK+PTRI   P+      G ++ L 
Sbjct: 477 NGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLE 536

Query: 519 CKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRV 578
           C+  HD SL +T  W    +P+        +   R +     L I  +     G Y C  
Sbjct: 537 CRVKHDPSLKLTVSWLKDDEPL--------YIGNRMKKEDDSLTIFGVAERDQGSYTCVA 588

Query: 579 QTTADSVSDEAELLVRG 595
            T  D    +A L V G
Sbjct: 589 STELDQDLAKAYLTVLG 605



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 97/374 (25%), Positives = 154/374 (41%), Gaps = 39/374 (10%)

Query: 47  LNCEVRGNPVPSYRWLRNGTEIDLESDY-RYSLIDGTFIISNPSEAKDSGHYQCLATNTV 105
           L C   G P P   W + G   DL SD  ++   +    I+N SE +DSG Y CLA+N +
Sbjct: 260 LECIASGVPTPDIAWYKKGG--DLPSDKAKFENFNKALRITNVSE-EDSGEYFCLASNKM 316

Query: 106 GSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFV 165
           GSI     +++      +    ++ + +  G+   L+C    + P+    W+ N  P   
Sbjct: 317 GSI-RHTISVRVKAAPYWLDEPKNLI-LAPGEDGRLVCRANGN-PKPTVQWMVNGEPLQS 373

Query: 166 AEDS-RRFISQETGNLYISKVQTSDVGSYICLVKNT----VTNARVLS---PPTPLTLRN 217
           A  +  R ++ +T  +     Q S    Y C   N     + NA V     PP  L+ RN
Sbjct: 374 APPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 431

Query: 218 DGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGY---IPSKARLR 274
                             +        +++C   G+P+PT+ W K NG    +       
Sbjct: 432 Q----------------LIRVILYNRTRLDCPFFGSPIPTLRWFK-NGQGSNLDGGNYHV 474

Query: 275 KSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLR 334
                LEI  ++ +D GIY C A N  GK   + +L+V           D     G+ ++
Sbjct: 475 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 534

Query: 335 WECKATGKP--RPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGA 392
            EC+    P  + T  WLK+  PL   +R++  +  L I  V + D G Y C+A  +   
Sbjct: 535 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 594

Query: 393 IYASAELKILASAP 406
             A A L +L + P
Sbjct: 595 DLAKAYLTVLGNCP 608


>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
          Length = 619

 Score =  244 bits (623), Expect = 3e-64
 Identities = 173/582 (29%), Positives = 260/582 (44%), Gaps = 38/582 (6%)

Query: 32  DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPS 89
           D I+ P D+    + + CE +GNP PS+ W RN    ++  D R S+    GT +I   S
Sbjct: 50  DHIVDPRDN----ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105

Query: 90  EAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 146
             +     G YQC A N  G+ LS    LQ +    +       V V+EG  + L C+PP
Sbjct: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPP 165

Query: 147 PHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA 204
           P  P  +  W+ +     + +D R  +SQ   G+LY S V   D+ + Y C  +   T+ 
Sbjct: 166 PGLPSPVIFWMSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT 222

Query: 205 RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA----KGTTVKMECFALGNPVPTITW 260
             +    P TL+     G  E      +P    ++    +G  + +EC A G P P I W
Sbjct: 223 --IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAW 280

Query: 261 MKVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWV 319
            K  G +PS KA+       L I NV  +D+G Y C A N  G       ++V   P+W+
Sbjct: 281 YKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL 340

Query: 320 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQ 376
           ++  +  L  G   R  C+A G P+PT +W+ NG PL    P    E+    ++  +   
Sbjct: 341 DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 400

Query: 377 SDAGMYQCLAENKYGAIYASAELKILASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGS 434
           S   +YQC   N++G + A+A + +L   P      NQL + I+  + +   ++C   GS
Sbjct: 401 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGS 457

Query: 435 PKPTISW-KKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLS 493
           P PT+ W K G  +  +     +  +GSL I    K D+G Y C   N+ G AE    L 
Sbjct: 458 PIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLE 517

Query: 494 VKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIR 553
           VK+PTRI   P+      G ++ L C+  HD SL +T  W    +P+        +   R
Sbjct: 518 VKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNR 569

Query: 554 AQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRG 595
            +     L I  +     G Y C   T  D    +A L V G
Sbjct: 570 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 97/374 (25%), Positives = 154/374 (41%), Gaps = 39/374 (10%)

Query: 47  LNCEVRGNPVPSYRWLRNGTEIDLESDY-RYSLIDGTFIISNPSEAKDSGHYQCLATNTV 105
           L C   G P P   W + G   DL SD  ++   +    I+N SE +DSG Y CLA+N +
Sbjct: 266 LECIASGVPTPDIAWYKKGG--DLPSDKAKFENFNKALRITNVSE-EDSGEYFCLASNKM 322

Query: 106 GSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFV 165
           GSI     +++      +    ++ + +  G+   L+C    + P+    W+ N  P   
Sbjct: 323 GSI-RHTISVRVKAAPYWLDEPKNLI-LAPGEDGRLVCRANGN-PKPTVQWMVNGEPLQS 379

Query: 166 AEDS-RRFISQETGNLYISKVQTSDVGSYICLVKNT----VTNARVLS---PPTPLTLRN 217
           A  +  R ++ +T  +     Q S    Y C   N     + NA V     PP  L+ RN
Sbjct: 380 APPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 437

Query: 218 DGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGY---IPSKARLR 274
                             +        +++C   G+P+PT+ W K NG    +       
Sbjct: 438 Q----------------LIRVILYNRTRLDCPFFGSPIPTLRWFK-NGQGSNLDGGNYHV 480

Query: 275 KSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLR 334
                LEI  ++ +D GIY C A N  GK   + +L+V           D     G+ ++
Sbjct: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540

Query: 335 WECKATGKP--RPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGA 392
            EC+    P  + T  WLK+  PL   +R++  +  L I  V + D G Y C+A  +   
Sbjct: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600

Query: 393 IYASAELKILASAP 406
             A A L +L + P
Sbjct: 601 DLAKAYLTVLGNCP 614



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 66/305 (21%), Positives = 124/305 (40%), Gaps = 40/305 (13%)

Query: 320 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN----GVPLSPQSRVEMVNGVLMIH--- 372
           +   D  +D    +  EC+A G P P++ W +N     +   P+  +   +G L+I    
Sbjct: 46  QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105

Query: 373 -NVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK- 430
               +   G YQC A NK+G   ++     ++ +P +    L   ++V +   + ++C  
Sbjct: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNP 164

Query: 431 PQGSPKPTISWKKGD-RAVRENKRIAILPDGSLRILNASKSD-EGKYVCRG--------- 479
           P G P P I W       + ++KR++   +G L   N    D +  Y C           
Sbjct: 165 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 224

Query: 480 -ENVFGSAEIIASLSVKEPTRIELTPKRTE----LTVGESIVLNCKAIHDASLDVTFYWT 534
            +N F + +++ +  V E T   + P+ T     +  G  ++L C A    + D+ +Y  
Sbjct: 225 QKNPF-TLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWY-- 281

Query: 535 LKGQPIDFEEEGGHFESIRAQASSAD--LMIRNILLMHAGRYGCRVQTTADSVSDEAELL 592
                    ++GG   S +A+  + +  L I N+    +G Y C       S+     + 
Sbjct: 282 ---------KKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 332

Query: 593 VRGPP 597
           V+  P
Sbjct: 333 VKAAP 337



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 38/178 (21%), Positives = 76/178 (42%), Gaps = 21/178 (11%)

Query: 402 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 459
           L   PT      K  I+  +D  ++IEC+ +G+P P+  W +  R   + ++ R+++   
Sbjct: 37  LTQPPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95

Query: 460 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 510
               +++       +  EG+Y C   N FG+A  +++    + ++  L PK       + 
Sbjct: 96  SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA--LSNRIRLQVSKSPLWPKENLDPVVVQ 153

Query: 511 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL 568
            G  + L C         V F+ +   +PI  ++         +Q  + DL   N++L
Sbjct: 154 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR-------VSQGHNGDLYFSNVML 204


>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
            precursor [Homo sapiens]
          Length = 2012

 Score =  239 bits (609), Expect = 1e-62
 Identities = 243/933 (26%), Positives = 393/933 (42%), Gaps = 75/933 (8%)

Query: 44   KVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATN 103
            +V+L+C V G       W RNG  ++   + R + I+   +I +     D G YQC    
Sbjct: 330  QVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRK 389

Query: 104  TVGSILSREATLQFAYLGNFSGRTRSAVS---VREGQGVVLMCSPPPHSPEIIYSWVFNE 160
                 LS +  +Q   L + + +  SA S   V   + V LMC+    +P    +W  ++
Sbjct: 390  DK---LSAQDYVQVV-LEDGTPKIISAFSEKVVSPAEPVSLMCNVKG-TPLPTITWTLDD 444

Query: 161  FPSFVAEDSR--RFISQETGN----LYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLT 214
             P       R  + I+ E GN    L IS  Q  D G Y C   N+              
Sbjct: 445  DPILKGGSHRISQMITSE-GNVVSYLNISSSQVRDGGVYRCTANNSA------------- 490

Query: 215  LRNDGVMGEYEPKIEVHFPFTV------TAAKGTTVKMECFALGNPVPTITWMKVNGYIP 268
                GV+  Y+ +I V  P ++      TA  G    + C  +G P  +I W K +  +P
Sbjct: 491  ----GVV-LYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLP 545

Query: 269  SKAR--LRKSQAVLEIPNVQLD-DAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDT 325
               R    ++   L++ +VQ + D G Y C        ++ +        P +++     
Sbjct: 546  FNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFP 605

Query: 326  QLDSGSPLRWECKATGKPRP-TYRWLKNGVPLSPQSRVEMVN----GVLMIHNVNQSDAG 380
            +   G  +   C       P T  W K+G P+     V + N      L I N++    G
Sbjct: 606  RFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNG 665

Query: 381  MYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTIS 440
             Y C+A N+  A+   ++L I+   P F +    +  I  K   V++ C  +G P PTI 
Sbjct: 666  NYTCIARNEAAAVEHQSQL-IVRVPPKFVVQPRDQDGIYGK--AVILNCSAEGYPVPTIV 722

Query: 441  WKKGDRA-------VRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIAS-- 491
            WK    A       +  N RI +L +GSL I +  + D G Y+C+  N  G A++  S  
Sbjct: 723  WKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVG-ADVSKSMY 781

Query: 492  LSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFES 551
            L+VK P  I   P  T  T G+   ++C A  +  + V   W  + + I+  E   +  S
Sbjct: 782  LTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVR--WEKEDRIIN-PEMARYLVS 838

Query: 552  IRAQASS--ADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEIT 609
             +       + L I   +   +G + C    +        +L V+ PP PP I I +++ 
Sbjct: 839  TKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEI-KDVK 897

Query: 610  ESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVE 669
              T TL W+   D +SPI+ Y+++ ++  S  W + +   ++ +  + SA  +D++P   
Sbjct: 898  ARTITLRWTMGFDGNSPITGYDIECKNK-SDSWDSAQRTKDV-SPQLNSATIIDIHPSST 955

Query: 670  YEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQN 729
            Y  R+ A N IG  +PS     I  +EA P   P  V         + + W+   +  QN
Sbjct: 956  YSIRMYAKNRIGKSEPSN-ELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQN 1014

Query: 730  GEGFGYIVAFRPNGTRGWKEKMVTSSEAS--KFIYRDESVPPLTPFEVKVGVYNNKGDGP 787
            G   GY + +R   T G  +  + S + S    +Y  +++   T + + V   N  G GP
Sbjct: 1015 GIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGP 1074

Query: 788  FSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHI-KESL-GRPQGFEVGYWKDMEQ 845
             SQ ++  + E  PS  P +V+A + S   I ++W  + KE+L G  QGF V YW ++  
Sbjct: 1075 SSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMD 1134

Query: 846  EDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPS 905
             +  E       +  + L GLE  T Y   V A+  AG G  S ++   TK+  P     
Sbjct: 1135 GELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAG 1194

Query: 906  NLRWEQQGSQVSLGWEPVIPLANESEVVGYKVF 938
                    S V + W P  PL     +  Y VF
Sbjct: 1195 VKAAAASASMVFVSWLP--PLKLNGIIRKYTVF 1225



 Score =  124 bits (311), Expect = 5e-28
 Identities = 149/613 (24%), Positives = 240/613 (39%), Gaps = 43/613 (7%)

Query: 7   LMLFLSVTMCLSESVDYGPVFVQEP-DDIIFPTDSDEKKVALNCEVRGNPVPSYRW-LRN 64
           L LF S     SE +     FV     +++F + +      + C   G P  + RW L  
Sbjct: 6   LSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTG---TLVPCPAAGIPPVTLRWYLAT 62

Query: 65  GTEIDLESDYRYSLIDGTFII-----SNPSEAKDSGHYQCLATNTVGSILSREATLQFAY 119
           G EI      R+   +GT  I     S+ S       Y C A N  G I S++  ++   
Sbjct: 63  GEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVL 122

Query: 120 LGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGN 179
              ++ R     ++R G   V  C  P  S E   + V  E  +       RF+   TG 
Sbjct: 123 REPYTVRVEDQKTMR-GNVAVFKCIIPS-SVEAYITVVSWEKDTVSLVSGSRFLITSTGA 180

Query: 180 LYISKVQTSD-VGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTA 238
           LYI  VQ  D + +Y C+ ++  T     S    L + +        P I   F      
Sbjct: 181 LYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPA---NSAPSILDGFDHRKAM 237

Query: 239 AKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAE 298
           A G  V++ C ALG+P P   W+K N  +    R +K+   L I N++  D+G Y C   
Sbjct: 238 A-GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVS 296

Query: 299 NSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSP 358
           N  G     G+L V             +   GS +   C  TG       W +NG  L+P
Sbjct: 297 NRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNP 356

Query: 359 QSRVEMVNGV----LMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLK 414
              V  + G+    L++ ++ +SD G YQC    +   + A   ++++    T  +    
Sbjct: 357 GKNVR-ITGINHENLIMDHMVKSDGGAYQCFV--RKDKLSAQDYVQVVLEDGTPKIISAF 413

Query: 415 KTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRE--NKRIA--ILPDGS----LRILN 466
              +V+  + V + C  +G+P PTI+W   D  + +  + RI+  I  +G+    L I +
Sbjct: 414 SEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISS 473

Query: 467 ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDAS 526
           +   D G Y C   N  G     A ++V+ P  I    K      G    ++C+ I    
Sbjct: 474 SQVRDGGVYRCTANNSAGVVLYQARINVRGPASIR-PMKNITAIAGRDTYIHCRVIGYPY 532

Query: 527 LDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL-MHAGRYGCRVQTTAD-S 584
             + +Y      P +  +         A  ++  L + ++   +  G Y C V      S
Sbjct: 533 YSIKWYKNSNLLPFNHRQV--------AFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLS 584

Query: 585 VSDEAELLVRGPP 597
            S    + V+ PP
Sbjct: 585 TSQSVHVTVKVPP 597



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 231/1065 (21%), Positives = 387/1065 (36%), Gaps = 180/1065 (16%)

Query: 25   PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVP-SYRWLRNGTEIDLESDYRYSLIDGT- 82
            P F+Q  +   FP  S  ++V + C V    +P +  W ++G  I          ID T 
Sbjct: 596  PPFIQPFE---FPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTS 652

Query: 83   -FIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVL 141
               ISN S    +G+Y C+A N   ++   ++ L       F  + R    +  G+ V+L
Sbjct: 653  SLRISNLS-LMHNGNYTCIARNEAAAV-EHQSQLIVRVPPKFVVQPRDQDGIY-GKAVIL 709

Query: 142  MCSPPPHS-PEIIYSWVFNE---FPSF--VAEDSRRFISQETGNLYISKVQTSDVGSYIC 195
             CS   +  P I+  W F++    P F  +A + R  +    G+L I  V   D G Y+C
Sbjct: 710  NCSAEGYPVPTIV--WKFSKGAGVPQFQPIALNGRIQVLSN-GSLLIKHVVEEDSGYYLC 766

Query: 196  LVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPV 255
             V N V     +S    LT++   ++  Y        P T  A +G   +M C A G   
Sbjct: 767  KVSNDV--GADVSKSMYLTVKIPAMITSY--------PNTTLATQGQKKEMSCTAHGEKP 816

Query: 256  PTITWMKVNGYI-PSKARLRKSQ--------AVLEIPNVQLDDAGIYECRAENSRGKNSF 306
              + W K +  I P  AR   S         + L+I     +D+G + C A NS G++  
Sbjct: 817  IIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRG 876

Query: 307  RGQLQVYTYPHWVE-KLNDTQ-----------LDSGSPLRW---ECKATGKPRPTYRWLK 351
              QL V   P   E ++ D +            D  SP+     ECK       + +  K
Sbjct: 877  IIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTK 936

Query: 352  NGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILA--SAPTFA 409
            +   +SPQ     +N   +I +++ S     +  A+N+ G    S EL I A  +AP   
Sbjct: 937  D---VSPQ-----LNSATII-DIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPD-- 985

Query: 410  LNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASK 469
                         QEV +E  P  S    ++WK    A +++ +  I+    +     S 
Sbjct: 986  ----------GPPQEVHLE--PISSQSIRVTWK----APKKHLQNGIIRGYQIGYREYST 1029

Query: 470  SDEGKYVCRGENVFGSAEIIA----------SLSVKEPTRIELTPKRTEL--TVGESIVL 517
                ++     +  G +E+             L V+   R    P   E+  T  E +  
Sbjct: 1030 GGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPS 1089

Query: 518  ----NCKAIHDASLDVTFYW-TLKGQPID--------------FEEEGGHFESIRAQASS 558
                N +AI  +   ++  W TL  + ++               + E G  ++I     S
Sbjct: 1090 YPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPS 1149

Query: 559  ADL---------MIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEIT 609
             +L          I+ +    AG  G R +       ++        PGPP  V     +
Sbjct: 1150 LELDGLEKYTNYSIQVLAFTRAGD-GVRSEQIFTRTKEDV-------PGPPAGVKAAAAS 1201

Query: 610  ESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVE 669
             S   +SW P    +  I  Y +    P+       +  P     D  S    +L+   +
Sbjct: 1202 ASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASP-----DSFSYRIPNLSRNRQ 1256

Query: 670  YEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGR-----RHELVIAWEPVS 724
            Y   VVA    G G+ S     I T E + K AP  +   SG        ++V+  + V 
Sbjct: 1257 YSVWVVAVTSAGRGNSSE----IITVEPLAK-APARILTFSGTVTTPWMKDIVLPCKAVG 1311

Query: 725  EEFQNGEGFGYIVAFRPNGTRGW-KEKMVTSS----EASKFIYRDESVPPLTPFEVKVGV 779
            +               P+    W K+   T S    +  + I+ + S    T      G 
Sbjct: 1312 D---------------PSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGY 1356

Query: 780  YNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGY 839
            Y+   +  +    +I + + +       +  +  + S I ++W          +G+ + Y
Sbjct: 1357 YSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQY 1416

Query: 840  WKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSA-TTKKS 898
             +D  ++  +  +    +E    L  L+  T Y FT+ A NG G G  S  + A T  K 
Sbjct: 1417 SEDNSEQWGSFPISP--SERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKE 1474

Query: 899  PPSQAPSNLRWEQQGSQVSL---GWE----PVIPLANESEVVGYKVFYRQEGHSNSQVIE 951
            P       L      ++V L   GW     P+     E    G  V+      + +Q   
Sbjct: 1475 PQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVW------TTAQRTS 1528

Query: 952  TQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKI 996
              K   +  L +A  Y +++R  +  G     +     +Y G  I
Sbjct: 1529 LSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTI 1573


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score =  219 bits (559), Expect = 8e-57
 Identities = 228/871 (26%), Positives = 345/871 (39%), Gaps = 85/871 (9%)

Query: 9   LFLSVTMCLSESV---DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNG 65
           LF  + +C    +   D+ P  V+ P D+I    S  +   LNC+  G P P+  W + G
Sbjct: 10  LFGLICLCSGSRLRQEDFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGG 66

Query: 66  TEIDLESD----YRYSLIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQF 117
             ++ + D    +R  L  G+     I+       D G Y C+A N +G  +S  A+L+ 
Sbjct: 67  ERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV 126

Query: 118 AYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQET 177
           A L +   +  S V V  G+  V+ C PP   PE   SW  +  P    +D    I+   
Sbjct: 127 AILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRG 183

Query: 178 GNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVT 237
           G L I+  + SD G Y+C+  N V      S    LT+         E    V  P  + 
Sbjct: 184 GKLMITYTRKSDAGKYVCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLA 233

Query: 238 AAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRA 297
                + + +C A G+PVPT+ W K +G +P      +    L+I  V   D G Y C A
Sbjct: 234 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA 293

Query: 298 ENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG---- 353
           EN  GK      L V   PH+V K  D  +  G  + ++C+ATG P+P   W + G    
Sbjct: 294 ENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNL 353

Query: 354 ----VPLSPQSRVEM-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---ILASA 405
                P    SR  +   G L I NV +SD G Y C   N  G+I   A L+   ++A  
Sbjct: 354 LFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADR 413

Query: 406 PTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGSLRI 464
           P   + Q      V  D   V+ C   GSP PTI W+K G     ++ RI  L +G L+I
Sbjct: 414 PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQI 473

Query: 465 LNASKSDEGKYVCRGENVFGSAEIIASLSVKE------------PTRIELTPKRTELT-- 510
             A   D G+Y C      G A   A + V+E            P  I   P + E+T  
Sbjct: 474 RYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDV 533

Query: 511 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN----I 566
              ++ L+ +   ++    T Y                 E+++ + S+   +  N     
Sbjct: 534 SRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLF 593

Query: 567 LLMHAGRYG----------CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLS 616
           L+  A  YG           + Q    +        V+   G   + +      S++++ 
Sbjct: 594 LVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIE 653

Query: 617 WSPAADNHSP-ISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV- 674
                D  S  I  Y +  R   +   ++   V E+ T    S +  DL   V YE +  
Sbjct: 654 VHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKAR 713

Query: 675 VATNPIGTGDPSTPSRMIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQNGEG 732
              N     D  +  +  +T E  P   P    VS   G    ++++W+P  E+ QNG  
Sbjct: 714 PFFNEFQGAD--SEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMV 771

Query: 733 FGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDGPFS 789
             Y V    N TR    K V  S  S  I      P L P   + V+V      G G  S
Sbjct: 772 QEYKVWCLGNETRYHINKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSGVKS 825

Query: 790 QIVVI-CSAEGEPSAAPTDVKATSVSVSEIL 819
           +   I   A G P  +P D  + +  +S+++
Sbjct: 826 EPQFIQLDAHGNP-VSPEDQVSLAQQISDVV 855



 Score =  175 bits (443), Expect = 2e-43
 Identities = 205/765 (26%), Positives = 303/765 (39%), Gaps = 106/765 (13%)

Query: 189 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 248
           D G Y+C+ +N +  A   +    + +  D              P  V  A G    MEC
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 152

Query: 249 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 305
               G+P PTI+W K    +  K  R+      L I   +  DAG Y C   N  G + S
Sbjct: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212

Query: 306 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 365
              +L V   P +V++ ++  +       ++C+A G P PT RW K+   L P+SR E+ 
Sbjct: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 271

Query: 366 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQE 424
           +   L I  V   D G Y C+AEN  G   ASA L +    P F +    +  +V   + 
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV-QEPPHFVVKPRDQ--VVALGRT 328

Query: 425 VVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGKYV 476
           V  +C+  G+P+P I W++          +  + + R ++   G L I N  +SD G Y+
Sbjct: 329 VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI 388

Query: 477 CRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLDVT 530
           C+  NV GS    A L V +      P  I   P    + V  + VL+C A    S   T
Sbjct: 389 CQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPVPT 446

Query: 531 FYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAE 590
             W   G  +  ++      S   Q  +  L IR   L   GRY C   T +   +  A 
Sbjct: 447 ILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 500

Query: 591 LLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQAR 635
           + V+       PP P         P    V +++ +T TLSW P  ++ +  +SY ++A 
Sbjct: 501 IEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF 560

Query: 636 SPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSR 690
           S  S   WQT    VKT    I G         L P   Y F V A N  G  DPS  S 
Sbjct: 561 SHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQISD 611

Query: 691 MIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQNG 730
            ++T + +P +                     PT +S  S   H  V   +  S+  Q  
Sbjct: 612 PVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ-- 666

Query: 731 EGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDG 786
              GY + +RP+G       W    V +   +  +  D  +     +E+K   + N+  G
Sbjct: 667 ---GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEFQG 721

Query: 787 PFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDME 844
             S+I    + E  PSA P    V     + + ILV+W+   E        E   W  + 
Sbjct: 722 ADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-CLG 780

Query: 845 QEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 888
            E      KT    +F V++  L     Y   V A  GAG G  S
Sbjct: 781 NETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 825


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score =  219 bits (558), Expect = 1e-56
 Identities = 225/855 (26%), Positives = 339/855 (39%), Gaps = 82/855 (9%)

Query: 22  DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESD----YRYS 77
           D+ P  V+ P D+I    S  +   LNC+  G P P+  W + G  ++ + D    +R  
Sbjct: 65  DFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 121

Query: 78  LIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSV 133
           L  G+     I+       D G Y C+A N +G  +S  A+L+ A L +   +  S V V
Sbjct: 122 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 181

Query: 134 REGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSY 193
             G+  V+ C PP   PE   SW  +  P    +D    I+   G L I+  + SD G Y
Sbjct: 182 AVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRGGKLMITYTRKSDAGKY 238

Query: 194 ICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN 253
           +C+  N V      S    LT+         E    V  P  +      + + +C A G+
Sbjct: 239 VCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLAVTVDDSAEFKCEARGD 288

Query: 254 PVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 313
           PVPT+ W K +G +P      +    L+I  V   D G Y C AEN  GK      L V 
Sbjct: 289 PVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 348

Query: 314 TYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG--------VPLSPQSRVEM- 364
             PH+V K  D  +  G  + ++C+ATG P+P   W + G         P    SR  + 
Sbjct: 349 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 408

Query: 365 VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---ILASAPTFALNQLKKTIIVTK 421
             G L I NV +SD G Y C   N  G+I   A L+   ++A  P   + Q      V  
Sbjct: 409 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 468

Query: 422 DQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGE 480
           D   V+ C   GSP PTI W+K G     ++ RI  L +G L+I  A   D G+Y C   
Sbjct: 469 DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 528

Query: 481 NVFGSAEIIASLSVKE------------PTRIELTPKRTELT--VGESIVLNCKAIHDAS 526
              G A   A + V+E            P  I   P + E+T     ++ L+ +   ++ 
Sbjct: 529 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 588

Query: 527 LDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN----ILLMHAGRYG------- 575
              T Y                 E+++ + S+   +  N     L+  A  YG       
Sbjct: 589 ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 648

Query: 576 ---CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSP-ISSYN 631
               + Q    +        V+   G   + +      S++++      D  S  I  Y 
Sbjct: 649 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYK 708

Query: 632 LQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV-VATNPIGTGDPSTPSR 690
           +  R   +   ++   V E+ T    S +  DL   V YE +     N     D  +  +
Sbjct: 709 ILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGAD--SEIK 766

Query: 691 MIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWK 748
             +T E  P   P    VS   G    ++++W+P  E+ QNG    Y V    N TR   
Sbjct: 767 FAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHI 826

Query: 749 EKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDGPFSQIVVI-CSAEGEPSAA 804
            K V  S  S  I      P L P   + V+V      G G  S+   I   A G P  +
Sbjct: 827 NKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNP-VS 879

Query: 805 PTDVKATSVSVSEIL 819
           P D  + +  +S+++
Sbjct: 880 PEDQVSLAQQISDVV 894



 Score =  175 bits (443), Expect = 2e-43
 Identities = 205/765 (26%), Positives = 303/765 (39%), Gaps = 106/765 (13%)

Query: 189 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 248
           D G Y+C+ +N +  A   +    + +  D              P  V  A G    MEC
Sbjct: 141 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 191

Query: 249 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 305
               G+P PTI+W K    +  K  R+      L I   +  DAG Y C   N  G + S
Sbjct: 192 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 251

Query: 306 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 365
              +L V   P +V++ ++  +       ++C+A G P PT RW K+   L P+SR E+ 
Sbjct: 252 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 310

Query: 366 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQE 424
           +   L I  V   D G Y C+AEN  G   ASA L +    P F +    +  +V   + 
Sbjct: 311 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV-QEPPHFVVKPRDQ--VVALGRT 367

Query: 425 VVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGKYV 476
           V  +C+  G+P+P I W++          +  + + R ++   G L I N  +SD G Y+
Sbjct: 368 VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI 427

Query: 477 CRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLDVT 530
           C+  NV GS    A L V +      P  I   P    + V  + VL+C A    S   T
Sbjct: 428 CQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPVPT 485

Query: 531 FYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAE 590
             W   G  +  ++      S   Q  +  L IR   L   GRY C   T +   +  A 
Sbjct: 486 ILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 539

Query: 591 LLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQAR 635
           + V+       PP P         P    V +++ +T TLSW P  ++ +  +SY ++A 
Sbjct: 540 IEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF 599

Query: 636 SPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSR 690
           S  S   WQT    VKT    I G         L P   Y F V A N  G  DPS  S 
Sbjct: 600 SHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQISD 650

Query: 691 MIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQNG 730
            ++T + +P +                     PT +S  S   H  V   +  S+  Q  
Sbjct: 651 PVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ-- 705

Query: 731 EGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDG 786
              GY + +RP+G       W    V +   +  +  D  +     +E+K   + N+  G
Sbjct: 706 ---GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEFQG 760

Query: 787 PFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDME 844
             S+I    + E  PSA P    V     + + ILV+W+   E        E   W  + 
Sbjct: 761 ADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-CLG 819

Query: 845 QEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 888
            E      KT    +F V++  L     Y   V A  GAG G  S
Sbjct: 820 NETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 864



 Score =  158 bits (400), Expect = 2e-38
 Identities = 206/851 (24%), Positives = 338/851 (39%), Gaps = 106/851 (12%)

Query: 210 PTPLTLRNDGVMG---------EYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITW 260
           P P +  +D  +G         ++ P+I  H P  +  +KG    + C A G P PTI W
Sbjct: 43  PIPTSDNDDNSLGYTGSRLRQEDFPPRIVEH-PSDLIVSKGEPATLNCKAEGRPTPTIEW 101

Query: 261 MKVNGYIPSKARLRKSQAVLEIPNVQL------------DDAGIYECRAENSRGKN-SFR 307
            K    + +     +S  +L +P+  L             D G+Y C A N  G+  S  
Sbjct: 102 YKGGERVETDKDDPRSHRML-LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHN 160

Query: 308 GQLQVYTY-PHWVEKLNDTQLDSGSPLRWECKAT-GKPRPTYRWLKNGVPLSPQS-RVEM 364
             L+V      + +  +D  +  G P   EC+   G P PT  W K+G PL  +  R+ +
Sbjct: 161 ASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI 220

Query: 365 VNGVLMIHNVNQSDAGMYQCLAENKYGAIYAS-AELKILASAPTFALNQLKKTIIVTKDQ 423
             G LMI    +SDAG Y C+  N  G   +  AEL +L   P+F   +    + VT D 
Sbjct: 221 RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL-ERPSFV--KRPSNLAVTVDD 277

Query: 424 EVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVF 483
               +C+ +G P PT+ W+K D  + ++ R  I  D +L+I   +  D G Y C  EN+ 
Sbjct: 278 SAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMV 336

Query: 484 GSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKG-QPIDF 542
           G AE  A+L+V+EP    + P+   + +G ++   C+A    +     +W  +G Q + F
Sbjct: 337 GKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA--TGNPQPAIFWRREGSQNLLF 394

Query: 543 EEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRG--PPGPP 600
             +     S  + + + DL I N+     G Y C+    A S+  +A L V       PP
Sbjct: 395 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 454

Query: 601 GIVIVEEITESTA---TLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDME 657
            ++    + ++ A   T   S  A   SP+ +  L  +    +  Q  + + ++  G ++
Sbjct: 455 PVIRQGPVNQTVAVDGTFVLSCVATG-SPVPTI-LWRKDGVLVSTQDSR-IKQLENGVLQ 511

Query: 658 SAMAVDLNPWVEYEFRVVATNPIGT------------GDPSTPSRMIRTNEAVPKTAPTN 705
              A  L     Y    +A+ P G             G P  P R   T+  +  +AP+ 
Sbjct: 512 IRYA-KLGDTGRY--TCIASTPSGEATWSAYIEVQEFGVPVQPPR--PTDPNLIPSAPSK 566

Query: 706 VSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWK---EKMVTSSEASKFIY 762
                  R+ + ++W+P          +  I AF       W+   E + T + A K   
Sbjct: 567 PEVTDVSRNTVTLSWQPNLNSGATPTSY-IIEAFSHASGSSWQTVAENVKTETSAIK--- 622

Query: 763 RDESVPPLTPFEVKVGVYNNKGDGPFSQIV-VICSAEGEPSAAPTDVK------------ 809
               + P   +   V   N  G    SQI   + + +  P++   D K            
Sbjct: 623 ---GLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLH 679

Query: 810 ---ATSVSVSEILVAWKHIKES--------LGRPQGFEVGYWKDMEQEDTAETVKTRGNE 858
               T +S S I V W   ++S        L RP G   G     E +     V+T    
Sbjct: 680 LHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHG-----ESDWLVFEVRTPAKN 734

Query: 859 SFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNL---RWEQQGSQ 915
           S V++  L     Y    R +     G  S    A T +  PS  P  +   + +  G+ 
Sbjct: 735 S-VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTA 793

Query: 916 VSLGWEPVIPLANESEVVGYKVFY--RQEGHSNSQVIETQKLQAVVPLPDAGV-YIIEVR 972
           + + W+P         V  YKV+    +  +  ++ ++      V+P    G+ Y +EV 
Sbjct: 794 ILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVA 853

Query: 973 AYSEGGDGTAS 983
           A +  G G  S
Sbjct: 854 ASTGAGSGVKS 864


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score =  214 bits (546), Expect = 3e-55
 Identities = 228/874 (26%), Positives = 345/874 (39%), Gaps = 88/874 (10%)

Query: 9   LFLSVTMCLSESV---DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNG 65
           LF  + +C    +   D+ P  V+ P D+I    S  +   LNC+  G P P+  W + G
Sbjct: 10  LFGLICLCSGSRLRQEDFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGG 66

Query: 66  TEIDLESD----YRYSLIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQF 117
             ++ + D    +R  L  G+     I+       D G Y C+A N +G  +S  A+L+ 
Sbjct: 67  ERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV 126

Query: 118 AYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQET 177
           A L +   +  S V V  G+  V+ C PP   PE   SW  +  P    +D    I+   
Sbjct: 127 AILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRG 183

Query: 178 GNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVT 237
           G L I+  + SD G Y+C+  N V      S    LT+         E    V  P  + 
Sbjct: 184 GKLMITYTRKSDAGKYVCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLA 233

Query: 238 AAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRA 297
                + + +C A G+PVPT+ W K +G +P      +    L+I  V   D G Y C A
Sbjct: 234 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA 293

Query: 298 ENSRGKNSFRGQLQVYT---YPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG- 353
           EN  GK      L V      PH+V K  D  +  G  + ++C+ATG P+P   W + G 
Sbjct: 294 ENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS 353

Query: 354 -------VPLSPQSRVEM-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---IL 402
                   P    SR  +   G L I NV +SD G Y C   N  G+I   A L+   ++
Sbjct: 354 QNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 413

Query: 403 ASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGS 461
           A  P   + Q      V  D   V+ C   GSP PTI W+K G     ++ RI  L +G 
Sbjct: 414 ADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGV 473

Query: 462 LRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE------------PTRIELTPKRTEL 509
           L+I  A   D G+Y C      G A   A + V+E            P  I   P + E+
Sbjct: 474 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV 533

Query: 510 T--VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN-- 565
           T     ++ L+ +   ++    T Y                 E+++ + S+   +  N  
Sbjct: 534 TDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAI 593

Query: 566 --ILLMHAGRYG----------CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTA 613
              L+  A  YG           + Q    +        V+   G   + +      S++
Sbjct: 594 YLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSS 653

Query: 614 TLSWSPAADNHSP-ISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEF 672
           ++      D  S  I  Y +  R   +   ++   V E+ T    S +  DL   V YE 
Sbjct: 654 SIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEI 713

Query: 673 RV-VATNPIGTGDPSTPSRMIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQN 729
           +     N     D  +  +  +T E  P   P    VS   G    ++++W+P  E+ QN
Sbjct: 714 KARPFFNEFQGAD--SEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQN 771

Query: 730 GEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDG 786
           G    Y V    N TR    K V  S  S  I      P L P   + V+V      G G
Sbjct: 772 GMVQEYKVWCLGNETRYHINKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSG 825

Query: 787 PFSQIVVI-CSAEGEPSAAPTDVKATSVSVSEIL 819
             S+   I   A G P  +P D  + +  +S+++
Sbjct: 826 VKSEPQFIQLDAHGNP-VSPEDQVSLAQQISDVV 858



 Score =  175 bits (443), Expect = 2e-43
 Identities = 205/767 (26%), Positives = 304/767 (39%), Gaps = 107/767 (13%)

Query: 189 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 248
           D G Y+C+ +N +  A   +    + +  D              P  V  A G    MEC
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 152

Query: 249 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 305
               G+P PTI+W K    +  K  R+      L I   +  DAG Y C   N  G + S
Sbjct: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212

Query: 306 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 365
              +L V   P +V++ ++  +       ++C+A G P PT RW K+   L P+SR E+ 
Sbjct: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 271

Query: 366 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASA--PTFALNQLKKTIIVTKD 422
           +   L I  V   D G Y C+AEN  G   ASA L +   +  P F +    +  +V   
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ--VVALG 329

Query: 423 QEVVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGK 474
           + V  +C+  G+P+P I W++          +  + + R ++   G L I N  +SD G 
Sbjct: 330 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 389

Query: 475 YVCRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLD 528
           Y+C+  NV GS    A L V +      P  I   P    + V  + VL+C A    S  
Sbjct: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPV 447

Query: 529 VTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDE 588
            T  W   G  +  ++      S   Q  +  L IR   L   GRY C   T +   +  
Sbjct: 448 PTILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 501

Query: 589 AELLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQ 633
           A + V+       PP P         P    V +++ +T TLSW P  ++ +  +SY ++
Sbjct: 502 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 561

Query: 634 ARSPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTP 688
           A S  S   WQT    VKT    I G         L P   Y F V A N  G  DPS  
Sbjct: 562 AFSHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQI 612

Query: 689 SRMIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQ 728
           S  ++T + +P +                     PT +S  S   H  V   +  S+  Q
Sbjct: 613 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ 669

Query: 729 NGEGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKG 784
                GY + +RP+G       W    V +   +  +  D  +     +E+K   + N+ 
Sbjct: 670 -----GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEF 722

Query: 785 DGPFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKD 842
            G  S+I    + E  PSA P    V     + + ILV+W+   E        E   W  
Sbjct: 723 QGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-C 781

Query: 843 MEQEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 888
           +  E      KT    +F V++  L     Y   V A  GAG G  S
Sbjct: 782 LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 828


>gi|224994171 roundabout 1 isoform c [Homo sapiens]
          Length = 1606

 Score =  214 bits (546), Expect = 3e-55
 Identities = 228/874 (26%), Positives = 345/874 (39%), Gaps = 88/874 (10%)

Query: 9   LFLSVTMCLSESV---DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNG 65
           LF  + +C    +   D+ P  V+ P D+I    S  +   LNC+  G P P+  W + G
Sbjct: 10  LFGLICLCSGSRLRQEDFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGG 66

Query: 66  TEIDLESD----YRYSLIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQF 117
             ++ + D    +R  L  G+     I+       D G Y C+A N +G  +S  A+L+ 
Sbjct: 67  ERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV 126

Query: 118 AYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQET 177
           A L +   +  S V V  G+  V+ C PP   PE   SW  +  P    +D    I+   
Sbjct: 127 AILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRG 183

Query: 178 GNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVT 237
           G L I+  + SD G Y+C+  N V      S    LT+         E    V  P  + 
Sbjct: 184 GKLMITYTRKSDAGKYVCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLA 233

Query: 238 AAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRA 297
                + + +C A G+PVPT+ W K +G +P      +    L+I  V   D G Y C A
Sbjct: 234 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA 293

Query: 298 ENSRGKNSFRGQLQVYT---YPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG- 353
           EN  GK      L V      PH+V K  D  +  G  + ++C+ATG P+P   W + G 
Sbjct: 294 ENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS 353

Query: 354 -------VPLSPQSRVEM-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---IL 402
                   P    SR  +   G L I NV +SD G Y C   N  G+I   A L+   ++
Sbjct: 354 QNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 413

Query: 403 ASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGS 461
           A  P   + Q      V  D   V+ C   GSP PTI W+K G     ++ RI  L +G 
Sbjct: 414 ADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGV 473

Query: 462 LRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE------------PTRIELTPKRTEL 509
           L+I  A   D G+Y C      G A   A + V+E            P  I   P + E+
Sbjct: 474 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV 533

Query: 510 T--VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN-- 565
           T     ++ L+ +   ++    T Y                 E+++ + S+   +  N  
Sbjct: 534 TDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAI 593

Query: 566 --ILLMHAGRYG----------CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTA 613
              L+  A  YG           + Q    +        V+   G   + +      S++
Sbjct: 594 YLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSS 653

Query: 614 TLSWSPAADNHSP-ISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEF 672
           ++      D  S  I  Y +  R   +   ++   V E+ T    S +  DL   V YE 
Sbjct: 654 SIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEI 713

Query: 673 RV-VATNPIGTGDPSTPSRMIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQN 729
           +     N     D  +  +  +T E  P   P    VS   G    ++++W+P  E+ QN
Sbjct: 714 KARPFFNEFQGAD--SEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQN 771

Query: 730 GEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDG 786
           G    Y V    N TR    K V  S  S  I      P L P   + V+V      G G
Sbjct: 772 GMVQEYKVWCLGNETRYHINKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSG 825

Query: 787 PFSQIVVI-CSAEGEPSAAPTDVKATSVSVSEIL 819
             S+   I   A G P  +P D  + +  +S+++
Sbjct: 826 VKSEPQFIQLDAHGNP-VSPEDQVSLAQQISDVV 858



 Score =  175 bits (443), Expect = 2e-43
 Identities = 205/767 (26%), Positives = 304/767 (39%), Gaps = 107/767 (13%)

Query: 189 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 248
           D G Y+C+ +N +  A   +    + +  D              P  V  A G    MEC
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 152

Query: 249 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 305
               G+P PTI+W K    +  K  R+      L I   +  DAG Y C   N  G + S
Sbjct: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212

Query: 306 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 365
              +L V   P +V++ ++  +       ++C+A G P PT RW K+   L P+SR E+ 
Sbjct: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 271

Query: 366 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASA--PTFALNQLKKTIIVTKD 422
           +   L I  V   D G Y C+AEN  G   ASA L +   +  P F +    +  +V   
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ--VVALG 329

Query: 423 QEVVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGK 474
           + V  +C+  G+P+P I W++          +  + + R ++   G L I N  +SD G 
Sbjct: 330 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 389

Query: 475 YVCRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLD 528
           Y+C+  NV GS    A L V +      P  I   P    + V  + VL+C A    S  
Sbjct: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPV 447

Query: 529 VTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDE 588
            T  W   G  +  ++      S   Q  +  L IR   L   GRY C   T +   +  
Sbjct: 448 PTILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 501

Query: 589 AELLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQ 633
           A + V+       PP P         P    V +++ +T TLSW P  ++ +  +SY ++
Sbjct: 502 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 561

Query: 634 ARSPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTP 688
           A S  S   WQT    VKT    I G         L P   Y F V A N  G  DPS  
Sbjct: 562 AFSHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQI 612

Query: 689 SRMIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQ 728
           S  ++T + +P +                     PT +S  S   H  V   +  S+  Q
Sbjct: 613 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ 669

Query: 729 NGEGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKG 784
                GY + +RP+G       W    V +   +  +  D  +     +E+K   + N+ 
Sbjct: 670 -----GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEF 722

Query: 785 DGPFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKD 842
            G  S+I    + E  PSA P    V     + + ILV+W+   E        E   W  
Sbjct: 723 QGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-C 781

Query: 843 MEQEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 888
           +  E      KT    +F V++  L     Y   V A  GAG G  S
Sbjct: 782 LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 828


>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
           sapiens]
          Length = 1562

 Score =  214 bits (546), Expect = 3e-55
 Identities = 228/874 (26%), Positives = 345/874 (39%), Gaps = 88/874 (10%)

Query: 9   LFLSVTMCLSESV---DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNG 65
           LF  + +C    +   D+ P  V+ P D+I    S  +   LNC+  G P P+  W + G
Sbjct: 10  LFGLICLCSGSRLRQEDFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGG 66

Query: 66  TEIDLESD----YRYSLIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQF 117
             ++ + D    +R  L  G+     I+       D G Y C+A N +G  +S  A+L+ 
Sbjct: 67  ERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV 126

Query: 118 AYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQET 177
           A L +   +  S V V  G+  V+ C PP   PE   SW  +  P    +D    I+   
Sbjct: 127 AILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRG 183

Query: 178 GNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVT 237
           G L I+  + SD G Y+C+  N V      S    LT+         E    V  P  + 
Sbjct: 184 GKLMITYTRKSDAGKYVCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLA 233

Query: 238 AAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRA 297
                + + +C A G+PVPT+ W K +G +P      +    L+I  V   D G Y C A
Sbjct: 234 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA 293

Query: 298 ENSRGKNSFRGQLQVYT---YPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG- 353
           EN  GK      L V      PH+V K  D  +  G  + ++C+ATG P+P   W + G 
Sbjct: 294 ENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS 353

Query: 354 -------VPLSPQSRVEM-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---IL 402
                   P    SR  +   G L I NV +SD G Y C   N  G+I   A L+   ++
Sbjct: 354 QNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 413

Query: 403 ASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGS 461
           A  P   + Q      V  D   V+ C   GSP PTI W+K G     ++ RI  L +G 
Sbjct: 414 ADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGV 473

Query: 462 LRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE------------PTRIELTPKRTEL 509
           L+I  A   D G+Y C      G A   A + V+E            P  I   P + E+
Sbjct: 474 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV 533

Query: 510 T--VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN-- 565
           T     ++ L+ +   ++    T Y                 E+++ + S+   +  N  
Sbjct: 534 TDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAI 593

Query: 566 --ILLMHAGRYG----------CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTA 613
              L+  A  YG           + Q    +        V+   G   + +      S++
Sbjct: 594 YLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSS 653

Query: 614 TLSWSPAADNHSP-ISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEF 672
           ++      D  S  I  Y +  R   +   ++   V E+ T    S +  DL   V YE 
Sbjct: 654 SIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEI 713

Query: 673 RV-VATNPIGTGDPSTPSRMIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQN 729
           +     N     D  +  +  +T E  P   P    VS   G    ++++W+P  E+ QN
Sbjct: 714 KARPFFNEFQGAD--SEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQN 771

Query: 730 GEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDG 786
           G    Y V    N TR    K V  S  S  I      P L P   + V+V      G G
Sbjct: 772 GMVQEYKVWCLGNETRYHINKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSG 825

Query: 787 PFSQIVVI-CSAEGEPSAAPTDVKATSVSVSEIL 819
             S+   I   A G P  +P D  + +  +S+++
Sbjct: 826 VKSEPQFIQLDAHGNP-VSPEDQVSLAQQISDVV 858



 Score =  175 bits (443), Expect = 2e-43
 Identities = 205/767 (26%), Positives = 304/767 (39%), Gaps = 107/767 (13%)

Query: 189 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 248
           D G Y+C+ +N +  A   +    + +  D              P  V  A G    MEC
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 152

Query: 249 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 305
               G+P PTI+W K    +  K  R+      L I   +  DAG Y C   N  G + S
Sbjct: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212

Query: 306 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 365
              +L V   P +V++ ++  +       ++C+A G P PT RW K+   L P+SR E+ 
Sbjct: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 271

Query: 366 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASA--PTFALNQLKKTIIVTKD 422
           +   L I  V   D G Y C+AEN  G   ASA L +   +  P F +    +  +V   
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ--VVALG 329

Query: 423 QEVVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGK 474
           + V  +C+  G+P+P I W++          +  + + R ++   G L I N  +SD G 
Sbjct: 330 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 389

Query: 475 YVCRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLD 528
           Y+C+  NV GS    A L V +      P  I   P    + V  + VL+C A    S  
Sbjct: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPV 447

Query: 529 VTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDE 588
            T  W   G  +  ++      S   Q  +  L IR   L   GRY C   T +   +  
Sbjct: 448 PTILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 501

Query: 589 AELLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQ 633
           A + V+       PP P         P    V +++ +T TLSW P  ++ +  +SY ++
Sbjct: 502 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 561

Query: 634 ARSPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTP 688
           A S  S   WQT    VKT    I G         L P   Y F V A N  G  DPS  
Sbjct: 562 AFSHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQI 612

Query: 689 SRMIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQ 728
           S  ++T + +P +                     PT +S  S   H  V   +  S+  Q
Sbjct: 613 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ 669

Query: 729 NGEGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKG 784
                GY + +RP+G       W    V +   +  +  D  +     +E+K   + N+ 
Sbjct: 670 -----GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEF 722

Query: 785 DGPFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKD 842
            G  S+I    + E  PSA P    V     + + ILV+W+   E        E   W  
Sbjct: 723 QGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-C 781

Query: 843 MEQEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 888
           +  E      KT    +F V++  L     Y   V A  GAG G  S
Sbjct: 782 LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 828


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,897,612
Number of Sequences: 37866
Number of extensions: 2017746
Number of successful extensions: 16957
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 291
Number of HSP's successfully gapped in prelim test: 232
Number of HSP's that attempted gapping in prelim test: 5119
Number of HSP's gapped (non-prelim): 4227
length of query: 1026
length of database: 18,247,518
effective HSP length: 112
effective length of query: 914
effective length of database: 14,006,526
effective search space: 12801964764
effective search space used: 12801964764
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.