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Search of human proteins with 28373126
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28373126 contactin 4 isoform c precursor [Homo sapiens]
(698 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28373126 contactin 4 isoform c precursor [Homo sapiens] 1408 0.0
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 1408 0.0
gi|75709184 contactin 3 [Homo sapiens] 921 0.0
gi|7657361 contactin 6 [Homo sapiens] 871 0.0
gi|7657359 contactin 5 isoform long [Homo sapiens] 734 0.0
gi|28373129 contactin 5 isoform short [Homo sapiens] 734 0.0
gi|4827022 contactin 2 precursor [Homo sapiens] 653 0.0
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens] 617 e-176
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens] 617 e-176
gi|28373124 contactin 4 isoform b precursor [Homo sapiens] 563 e-160
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 269 6e-72
gi|27894376 cell adhesion molecule with homology to L1CAM precur... 268 2e-71
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 265 1e-70
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens] 264 2e-70
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens] 264 2e-70
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 259 8e-69
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 259 8e-69
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 259 8e-69
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens] 256 7e-68
gi|222352127 sidekick 2 [Homo sapiens] 241 2e-63
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens] 238 2e-62
gi|119220552 sidekick 1 [Homo sapiens] 208 2e-53
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 196 6e-50
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 196 6e-50
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 193 4e-49
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 181 2e-45
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 174 3e-43
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 174 3e-43
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 173 4e-43
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 166 5e-41
>gi|28373126 contactin 4 isoform c precursor [Homo sapiens]
Length = 698
Score = 1408 bits (3644), Expect = 0.0
Identities = 698/698 (100%), Positives = 698/698 (100%)
Query: 1 MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN 60
MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN
Sbjct: 1 MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN 60
Query: 61 KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL 120
KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL
Sbjct: 61 KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL 120
Query: 121 KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMD 180
KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMD
Sbjct: 121 KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMD 180
Query: 181 VTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQL 240
VTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQL
Sbjct: 181 VTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQL 240
Query: 241 KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPIT 300
KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPIT
Sbjct: 241 KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPIT 300
Query: 301 MYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRP 360
MYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRP
Sbjct: 301 MYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRP 360
Query: 361 SEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWM 420
SEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWM
Sbjct: 361 SEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWM 420
Query: 421 LTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASI 480
LTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASI
Sbjct: 421 LTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASI 480
Query: 481 FARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLK 540
FARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLK
Sbjct: 481 FARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLK 540
Query: 541 GSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALD 600
GSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALD
Sbjct: 541 GSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALD 600
Query: 601 NESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIR 660
NESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIR
Sbjct: 601 NESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIR 660
Query: 661 IPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL 698
IPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL
Sbjct: 661 IPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL 698
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 1408 bits (3644), Expect = 0.0
Identities = 698/698 (100%), Positives = 698/698 (100%)
Query: 1 MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN 60
MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN
Sbjct: 329 MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN 388
Query: 61 KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL 120
KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL
Sbjct: 389 KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL 448
Query: 121 KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMD 180
KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMD
Sbjct: 449 KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMD 508
Query: 181 VTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQL 240
VTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQL
Sbjct: 509 VTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQL 568
Query: 241 KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPIT 300
KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPIT
Sbjct: 569 KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPIT 628
Query: 301 MYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRP 360
MYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRP
Sbjct: 629 MYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRP 688
Query: 361 SEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWM 420
SEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWM
Sbjct: 689 SEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWM 748
Query: 421 LTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASI 480
LTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASI
Sbjct: 749 LTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASI 808
Query: 481 FARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLK 540
FARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLK
Sbjct: 809 FARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLK 868
Query: 541 GSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALD 600
GSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALD
Sbjct: 869 GSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALD 928
Query: 601 NESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIR 660
NESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIR
Sbjct: 929 NESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIR 988
Query: 661 IPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL 698
IPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL
Sbjct: 989 IPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL 1026
Score = 82.8 bits (203), Expect = 1e-15
Identities = 79/289 (27%), Positives = 117/289 (40%), Gaps = 36/289 (12%)
Query: 2 EENVFWECKANGRPKPTYKWLKNGEPLLTRD--RIQIEQGTLNITIVNLS-DAGMYQCLA 58
E+ V C+ G PKP +W NG + T R + +G+L I N + DAG YQC A
Sbjct: 43 EKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTA 102
Query: 59 ENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGR- 117
N G I S A +F V++ + G V++ P S + Y W
Sbjct: 103 TNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEY 162
Query: 118 DILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVP-- 175
++N R E GNL I V KSD G+YTC+ TN + T + V+ PT +++
Sbjct: 163 PSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTN-----TVTNHKVLGPPTPLILRND 217
Query: 176 --------------PSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHF 221
P ++ G ++ L C + I++ + DG
Sbjct: 218 GVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRA----------DGKPI 267
Query: 222 ERVGGQ-DSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP 269
R + S G L I N Q + AG Y C+ + S + A L P
Sbjct: 268 ARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQP 316
Score = 62.4 bits (150), Expect = 1e-09
Identities = 67/261 (25%), Positives = 103/261 (39%), Gaps = 26/261 (9%)
Query: 18 TYKWLKNGEPLLTRDR--IQIEQGTLNITIVNLSDAGMYQCLAEN---KHGVIFSNAELS 72
+Y W+ N P +R + E G L I V SD G Y C+ N H V+ L
Sbjct: 154 SYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLI 213
Query: 73 VIAVG------PDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKK--GRDILKENE 124
+ G P + V K G V +EC +P P W++ G+ I ++
Sbjct: 214 LRNDGVMGEYEPKIEVQFPETVPTAK-GATVKLECFALGNPVPTIIWRRADGKPIARKAR 272
Query: 125 RITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVG 184
R +G L I N + DAG Y C+A N G + G L + + + V +
Sbjct: 273 RH--KSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAME 330
Query: 185 ESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAG 244
E++ C+ + + W NG + RD E+ G L I + L AG
Sbjct: 331 ENVFWECKA--NGRPKPTYKWLKNGEPL-LTRDRIQIEQ-------GTLNITIVNLSDAG 380
Query: 245 KYVCMVQTSVDRLSAAADLIV 265
Y C+ + + + A+L V
Sbjct: 381 MYQCLAENKHGVIFSNAELSV 401
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 921 bits (2381), Expect = 0.0
Identities = 433/693 (62%), Positives = 560/693 (80%), Gaps = 2/693 (0%)
Query: 1 MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN 60
+E++++WEC+A+G+PKP+Y+WLKNG L+ +R QIE G L I+ ++++D+GM+QC+AEN
Sbjct: 331 VEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIENGALTISNLSVTDSGMFQCIAEN 390
Query: 61 KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL 120
KHG+++S+AEL V+A PDFS+ +K++ V+VG V ++CKP+ASP+ + +WKKG +
Sbjct: 391 KHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSV 450
Query: 121 KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMD 180
+E+ERI++ DG L+I NVTK+DAG+YTC+A N FG A+ T +LVV +PTR+ + PS+MD
Sbjct: 451 QEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMD 510
Query: 181 VTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQL 240
V+VGES++LPCQV HD LDI+FTW FNG L DF +DG HFE+VGG S+GDLMIRNIQL
Sbjct: 511 VSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGS-SSGDLMIRNIQL 569
Query: 241 KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPIT 300
KH+GKYVCMVQT VD +S+AADLIVRG PGPPE V +DEITDTTAQLSW+ G DNHSP+
Sbjct: 570 KHSGKYVCMVQTGVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVI 629
Query: 301 MYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRP 360
Y IQARTPFSVGWQ V+TVPE+IDGKT TATVV LNPWVEYEFR VA+N IG GEPS P
Sbjct: 630 SYSIQARTPFSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLP 689
Query: 361 SEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWM 420
SEK RTEEA+PEV P+ V+GGGGS+SELVITW+ VPEELQNG GFGYVVAFRP G W+
Sbjct: 690 SEKVRTEEAVPEVPPSEVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVTTWI 749
Query: 421 LTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASI 480
TV+ S D RYVFRNES+ P+SP+EVKVGV+NNKGEGPFSP T V+SAEEEPT P+ +
Sbjct: 750 QTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQV 809
Query: 481 FARSLSATDIEVFWAS-PLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNL 539
A SLS+++IEV W + P + + G + GYEV+YW KEE++ K++ GN+TS ++ L
Sbjct: 810 SANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNETSARLRGL 869
Query: 540 KGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKAL 599
K ++ Y+ AV+AYNSAG GP SATVNVTT+K PPSQPPGN++WN++D+K++LNW+QVKA+
Sbjct: 870 KSNLAYYTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAM 929
Query: 600 DNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQI 659
+NESEV GYKV YR + Q++ V+ TNKTS EL LP EDYIIE+K +DGGDG+SSEQI
Sbjct: 930 ENESEVTGYKVFYRTSSQNNVQVLNTNKTSAELVLPIKEDYIIEVKATTDGGDGTSSEQI 989
Query: 660 RIPKISNAYARGSGASTSNACTLSAISTIMISL 692
RIP+I++ ARGS ++ SN +S+ I++ L
Sbjct: 990 RIPRITSMDARGSTSAISNVHPMSSYMPIVLFL 1022
Score = 129 bits (323), Expect = 1e-29
Identities = 165/691 (23%), Positives = 271/691 (39%), Gaps = 79/691 (11%)
Query: 8 ECKANGRPKPTYKWLKN-GEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIF 66
EC A G P P W ++ G P ++ +++ G L I DAG Y+C+AEN G
Sbjct: 248 ECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNV 307
Query: 67 SNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERI 126
+ L+ A P + + L+K V + V + EC+ PKP Y W K L ER
Sbjct: 308 ARGRLTYYA-KPHWVQ-LIKDVE-IAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERT 364
Query: 127 TISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVV--------KDPTRVMVPPSS 178
I E+G L I N++ +D+G + CIA N G S+ L V K+P + +V
Sbjct: 365 QI-ENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLV---- 419
Query: 179 MDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNI 238
V VG + L C+ S + +W D ER+ + G L I N+
Sbjct: 420 -QVQVGSLVSLDCKPR--ASPRALSSWKKG------DVSVQEHERISLLNDGG-LKIANV 469
Query: 239 QLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSP 298
AG Y CM + + + L+V P A + ++ + + P H P
Sbjct: 470 TKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDV--SVGESVILPCQVQHDP 527
Query: 299 I-----TMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIG 353
+ T Y A F V G + + ++ N +++ + V G
Sbjct: 528 LLDIIFTWYFNGALADFKKDGSHFEKV-----GGSSSGDLMIRNIQLKHSGKYVCMVQTG 582
Query: 354 IGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRP 413
+ S ++ P P NV + + ++W+ + + Y + R
Sbjct: 583 VDSVSSAADLIVRGSPGP---PENVKVDEITDTTAQLSWKEGKD--NHSPVISYSIQART 637
Query: 414 YGKMIW--MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEG-PFSPTTVVYSAE 470
+ W + TV D + ++P+ +E +V N G G P P+ V + E
Sbjct: 638 PFSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEE 697
Query: 471 EEPTKPPASIFARSLSATDIEVFW-ASPLEKNRGRIQGYEVKY-------WRHEDKEENA 522
P PP+ + S +++ + W P E G GY V + W
Sbjct: 698 AVPEVPPSEVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVTTW--------- 748
Query: 523 RKIRTVGNQTSTKITNLKGSVL-----YHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPP 577
I+TV T + + Y + V YN+ G GP S V + + P+ P
Sbjct: 749 --IQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAP 806
Query: 578 GNIIWNS-SDSKIILNWDQVKALDNESEVKGYKVLYRWN-----RQSSTSVIETNKTSVE 631
+ NS S S+I ++W+ + + + GY+V Y WN SS + N+TS
Sbjct: 807 SQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRY-WNGGGKEESSSKMKVAGNETSAR 865
Query: 632 L-SLPFDEDYIIEIKPFSDGGDGSSSEQIRI 661
L L + Y ++ ++ G G S + +
Sbjct: 866 LRGLKSNLAYYTAVRAYNSAGAGPFSATVNV 896
Score = 77.0 bits (188), Expect = 5e-14
Identities = 70/271 (25%), Positives = 116/271 (42%), Gaps = 30/271 (11%)
Query: 2 EENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLS---DAGMYQCLA 58
++ + C+A G P P Y+W NG + + + N+ ++N + D G YQC A
Sbjct: 43 DKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFA 102
Query: 59 ENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKA-SPKPVYTW---K 114
N G I S A +F +T ++ V+ G VV+ C P S + Y W +
Sbjct: 103 TNSLGTIVSREAKLQFAYLENF-KTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNE 161
Query: 115 KGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGN---LVVK---- 167
+ +++ R E G+L I V SD G+YTC+ T+ A G+ LV++
Sbjct: 162 YPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGV 221
Query: 168 ----DPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHF-E 222
+P + P ++ G ++ L C + I + S DG F
Sbjct: 222 MGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRS----------DGLPFSS 271
Query: 223 RVGGQDSAGDLMIRNIQLKHAGKYVCMVQTS 253
++ + +G L I N Q + AG Y C+ + S
Sbjct: 272 KIKLRKFSGVLEIPNFQQEDAGSYECIAENS 302
Score = 62.4 bits (150), Expect = 1e-09
Identities = 53/193 (27%), Positives = 82/193 (42%), Gaps = 25/193 (12%)
Query: 89 TLVKVGGE---VVIECKPKASPKPVYTWK-KGRDILKENERITISEDGNLRIINVTKS-D 143
++ VG E + + C+ + +P P Y W+ G DI E GNL +IN ++ D
Sbjct: 35 SIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWD 94
Query: 144 AGSYTCIATNHFGTASSTGNLV-------VKDPTRVMVPPSSMDVTVGESIVLPCQVTHD 196
G+Y C ATN GT S + K R S++ V G+ +VL C
Sbjct: 95 TGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMR-----STVSVREGQGVVLLCGPP-P 148
Query: 197 HSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDR 256
HS ++ + W FN + + D F G L I ++ G Y C+V + V
Sbjct: 149 HSGELSYAWIFNEYPSFVEEDSRRFV----SQETGHLYISKVEPSDVGNYTCVVTSMVTN 204
Query: 257 ---LSAAADLIVR 266
L + L++R
Sbjct: 205 ARVLGSPTPLVLR 217
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 871 bits (2250), Expect = 0.0
Identities = 407/670 (60%), Positives = 527/670 (78%), Gaps = 2/670 (0%)
Query: 3 ENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKH 62
+N+ WECKA+G+P P Y WLKNGE L +RIQIE GTL IT++N+SD+G+YQC AENK+
Sbjct: 333 DNLLWECKASGKPNPWYTWLKNGERLNPEERIQIENGTLIITMLNVSDSGVYQCAAENKY 392
Query: 63 GVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKE 122
+I++NAEL V+A PDFS++ +K+ + V+VGG++VI CKP A P+ +WK+G + L++
Sbjct: 393 QIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQ 452
Query: 123 NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVT 182
++RI + EDG+L+I N+T+SDAGSYTCIATN FGTA +TG+L+VK+ T + VPPS MDVT
Sbjct: 453 SKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVT 512
Query: 183 VGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKH 242
VGESIVLPCQV+HD S+++VF W FNG +ID + HFER+GG+ S GDLMIRNIQL H
Sbjct: 513 VGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGE-SVGDLMIRNIQLHH 571
Query: 243 AGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMY 302
+GKY+C VQT+++ LSA AD+IVRGPPGPPE V +++I+ TT+QLSWR GPDN+SPI ++
Sbjct: 572 SGKYLCTVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIF 631
Query: 303 VIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSE 362
IQ RTPFSVGWQAV+TVPE+++GKT+ ATVVGL+PWVEYEFR VA N IGIGEPS PSE
Sbjct: 632 TIQTRTPFSVGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSE 691
Query: 363 KRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLT 422
RT+ ++P V P N+ GGGGS+SELVITWE++PEELQNG GFGY++ FRP G W
Sbjct: 692 LLRTKASVPVVAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKE 751
Query: 423 VLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFA 482
++S ++SR+V+RNES+ P SPFEVKVGV+NN+GEG S T+VYS E+EP P
Sbjct: 752 KVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSL 811
Query: 483 RSLSATDIEVFW-ASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKG 541
+S SA+++EV W A +N GR+ GYEV YW + KE KIR GN T+ IT LK
Sbjct: 812 QSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKNITGLKA 871
Query: 542 SVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDN 601
+ +Y +V+AYN+AGTGPSS VNVTT+K PPSQPP NI W ++SK+ LNW+ VK ++N
Sbjct: 872 NTIYFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMEN 931
Query: 602 ESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRI 661
ESEV GYK+LYR NRQS T ++ETN TS EL +PF+EDY+IEI+ SDGGDGSSSE+IRI
Sbjct: 932 ESEVLGYKILYRQNRQSKTHILETNNTSAELLVPFEEDYLIEIRTVSDGGDGSSSEEIRI 991
Query: 662 PKISNAYARG 671
PK+S+ +RG
Sbjct: 992 PKMSSLSSRG 1001
Score = 119 bits (297), Expect = 1e-26
Identities = 163/700 (23%), Positives = 270/700 (38%), Gaps = 85/700 (12%)
Query: 2 EENVFWECKANGRPKPTYKWLK-NGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN 60
+ +V EC A G P P W + +G PL + + Q L I D G Y+C+A N
Sbjct: 242 DSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASN 301
Query: 61 KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL 120
G + +L + P++ + + T + + ++ ECK P P YTW K + L
Sbjct: 302 LRGRNLAKGQL-IFYAPPEWEQKIQN--THLSIYDNLLWECKASGKPNPWYTWLKNGERL 358
Query: 121 KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVV----KDPTRVMVPP 176
ERI I E+G L I + SD+G Y C A N + + L V D ++ V
Sbjct: 359 NPEERIQI-ENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKK 417
Query: 177 SSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGD---HFERVGGQDSAGDL 233
S V VG IV+ C+ +F I + R + +R+ + G L
Sbjct: 418 KSF-VQVGGDIVIGCKPN-----------AFPRAAISWKRGTETLRQSKRIFLLED-GSL 464
Query: 234 MIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRG------PPGPPEAVTIDEITDTTAQL 287
I NI AG Y C+ LIV+ PP + VT+ E Q+
Sbjct: 465 KIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMD-VTVGESIVLPCQV 523
Query: 288 SWRPGPD-------NHSPITMYVIQARTP----FSVGWQAVSTVPELIDGKTFTATVVGL 336
S P + N I + A SVG + + GK L
Sbjct: 524 SHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTL 583
Query: 337 NPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVP 396
E + A++I G P P E + E+ + + G + S + I
Sbjct: 584 ------ESLSAVADIIVRGPPG-PPEDVQVEDISSTTSQLSWRAGPDNNSPIQI------ 630
Query: 397 EELQNGRGFGYVVAFRPYGKMIW--MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNN 454
+ + R + W + TV + Y + P+ +E +V N+
Sbjct: 631 ----------FTIQTRTPFSVGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNS 680
Query: 455 KGEG-PFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWAS-PLEKNRGRIQGYEVKY 512
G G P P+ ++ + P P +I S +++ + W S P E G GY + +
Sbjct: 681 IGIGEPSEPSELLRTKASVPVVAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMF 740
Query: 513 WRHEDKEENARKIRTVGNQTSTKITNLKGSVL----YHLAVKAYNSAGTGP-SSATVNVT 567
+ K+ +V S++ S++ + + V YN+ G G S+ T+ +
Sbjct: 741 RPVGSTTWSKEKVSSV---ESSRFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYS 797
Query: 568 TRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNK 627
P P G + + S S++ ++W+ + N V GY+VLY W S S+I +
Sbjct: 798 GEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLY-WTDDSKESMIGKIR 856
Query: 628 TSVELS------LPFDEDYIIEIKPFSDGGDGSSSEQIRI 661
S ++ L + Y ++ ++ G G SS + +
Sbjct: 857 VSGNVTTKNITGLKANTIYFASVRAYNTAGTGPSSPPVNV 896
Score = 80.5 bits (197), Expect = 5e-15
Identities = 82/287 (28%), Positives = 111/287 (38%), Gaps = 30/287 (10%)
Query: 2 EENVFWECKANGRPKPTYKWLKNGEPL--LTRDRIQIEQGTLNITIVNLS-DAGMYQCLA 58
+ V C ANG P P Y+W +NG + +++ G+L I + D GMYQCLA
Sbjct: 43 KSEVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLA 102
Query: 59 ENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV-YTWKKGR 117
N G I S A DF T + V+ G VV+ C P + Y W
Sbjct: 103 TNLLGTILSRKAKLQFAYIEDFE-TKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFND 161
Query: 118 DIL---KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTAS-----------STGN 163
+ L ++N R E GNL I V SD G+YTC TN S + G
Sbjct: 162 NPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGV 221
Query: 164 LVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFE- 222
+ +P + P ++ S+ L C + DI +W DG
Sbjct: 222 MGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDI--SWR--------RLDGSPLPG 271
Query: 223 RVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP 269
+V S L I N Q + G Y C+ R A LI PP
Sbjct: 272 KVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPP 318
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 734 bits (1895), Expect = 0.0
Identities = 358/687 (52%), Positives = 471/687 (68%), Gaps = 7/687 (1%)
Query: 7 WECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIF 66
WECKA G+P+PTY+WLKNG PL + R+++ G L I VN SDAGMYQCLAENK+G I+
Sbjct: 409 WECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIY 468
Query: 67 SNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERI 126
++AEL ++A P F+ LK+ +V EVVIECKP+ SPKP +WKKG ++EN+RI
Sbjct: 469 ASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRI 528
Query: 127 TISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGES 186
I DG+LRI+N +KSD G Y C N FG+A +L VK+PTR+ + P ++TVGES
Sbjct: 529 AILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGES 588
Query: 187 IVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKY 246
IVL C+ HD SLD+ F W+ G IDF+ +G HFE + Q S+ DLMIRNI L HAG+Y
Sbjct: 589 IVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRY 648
Query: 247 VCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQA 306
C VQT+ D +S A+L+VRGPPGPP V ++EIT++TA LSW P DNHSPI+ Y +QA
Sbjct: 649 GCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQA 708
Query: 307 RTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRT 366
R+PFS+GWQ V TVPE+I G +A V LNPWVEYEFR VA N IG G+PS PS RT
Sbjct: 709 RSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRT 768
Query: 367 EEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLAS 426
EA+P+ P NVSG G + ELVI WE V EE QNG GFGY+VAFRP G W ++ S
Sbjct: 769 NEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTS 828
Query: 427 ADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLS 486
++AS++++R+ESV P +PFEVKVGV+NNKG+GPFS V+ SAE EP+ P + A S+S
Sbjct: 829 SEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVS 888
Query: 487 ATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYH 546
++I V W ++++ GR QG+EV YW+ ++E+ A ++T GN++ +T L+G+ LYH
Sbjct: 889 VSEILVAWKH-IKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYH 947
Query: 547 LAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVK 606
V+AYN AG GP S+ V+ TT+K PPSQ P N+ W S++ L W+ V L NESEV
Sbjct: 948 FTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVV 1007
Query: 607 GYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISN 666
GYKV YR S++ VIET K + LP YIIE++ +S+GGDG++S QIR+P S
Sbjct: 1008 GYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYS- 1066
Query: 667 AYARGSGASTSNACTLSAISTIMISLT 693
G TS TL ++ST S+T
Sbjct: 1067 -----GGKITSAQSTLHSLSTSSSSVT 1088
Score = 96.7 bits (239), Expect = 7e-20
Identities = 80/267 (29%), Positives = 115/267 (43%), Gaps = 22/267 (8%)
Query: 8 ECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFS 67
EC A G P PT W+K + ++ R++ Q L I V L DAG+Y+C AEN G
Sbjct: 321 ECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSF 380
Query: 68 NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERIT 127
+L V P + L T + G + ECK P+P Y W K L R+
Sbjct: 381 RGQLQVYTY-PHWVEKL--NDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVE 437
Query: 128 ISEDGNLRIINVTKSDAGSYTCIATNHFGT--ASSTGNLVVKDPTRVMVP-PSSMDVTVG 184
+ +G L I NV +SDAG Y C+A N +G AS+ ++ PT + ++ VT
Sbjct: 438 M-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKD 496
Query: 185 ESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSA---GDLMIRNIQLK 241
+ +V+ C+ S +W + GD R + + G L I N
Sbjct: 497 QEVVIECK--PQGSPKPTISW----------KKGDRAVRENKRIAILPDGSLRILNASKS 544
Query: 242 HAGKYVCMVQTSVDRLSAAADLIVRGP 268
GKYVC + A L V+ P
Sbjct: 545 DEGKYVCRGENVFGSAEIIASLSVKEP 571
Score = 87.0 bits (214), Expect = 5e-17
Identities = 164/729 (22%), Positives = 265/729 (36%), Gaps = 121/729 (16%)
Query: 2 EENVFWECKANGRPKPTYKWLKNGEPL-LTRD-RIQIEQGTLNITIVN-LSDAGMYQCLA 58
E+ V C+ G P P+Y+WL+NG + L D R + GT I+ + D+G YQCLA
Sbjct: 116 EKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLA 175
Query: 59 ENKHGVIFS-NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKA-SPKPVYTW--- 113
N G I S A L +G RT + V+ G VV+ C P SP+ +Y+W
Sbjct: 176 TNTVGSILSREATLQFAYLGNFSGRT--RSAVSVREGQGVVLMCSPPPHSPEIIYSWVFN 233
Query: 114 KKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVM 173
+ + +++ R E GNL I V SD GSY C+ N A RV+
Sbjct: 234 EFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNA------------RVL 281
Query: 174 VPPSSM----DVTVGE-----SIVLPCQVTHDHSLDI------------VFTW-SFNGHL 211
PP+ + D +GE + P VT + TW NG++
Sbjct: 282 SPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYI 341
Query: 212 IDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGP 271
+ + S L I N+QL AG Y C + S + S L V P
Sbjct: 342 P---------SKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHW 392
Query: 272 PEAVTIDEITDTTAQLSW------RPGP-----DNHSPITMYVIQARTPFSVGWQAVSTV 320
E + D D+ + L W +P P N P++ Q+R G + V
Sbjct: 393 VEKLN-DTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSP---QSRVEMVNGVLMIHNV 448
Query: 321 PELIDG--KTFTATVVGLNPWVEYEFRTVA-ANVIGIGEPSRPSEKRRTEEALPEVTPAN 377
+ G + G + E + +A A + + + + +E + E P
Sbjct: 449 NQSDAGMYQCLAENKYGA-IYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQ- 506
Query: 378 VSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNE 437
G K I+W+ ++ + +A P G + + + +D +YV R E
Sbjct: 507 ----GSPKP--TISWKKGDRAVRENKR----IAILPDGSL--RILNASKSDEGKYVCRGE 554
Query: 438 SVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASP 497
+V + + V +P + E +I SL D+ +W
Sbjct: 555 NVFGSAEIIASLSV-KEPTRIELTPKRTELTVGESIVLNCKAIHDASL---DVTFYWT-- 608
Query: 498 LEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGT 557
++G + D EE ++ Q S+ ++ +L H T
Sbjct: 609 -------LKGQPI------DFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTT 655
Query: 558 GPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYR---- 613
S + + PP P I+ ++S L+W A DN S + Y + R
Sbjct: 656 ADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWS--PAADNHSPISSYNLQARSPFS 713
Query: 614 --WNRQSSTSVIETNKTSVELSLPFD-----EDYIIEIKPFSDGGDGSSSEQIR----IP 662
W + I T +++ + E ++ P G + S IR +P
Sbjct: 714 LGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVP 773
Query: 663 KISNAYARG 671
K + G
Sbjct: 774 KTAPTNVSG 782
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 734 bits (1895), Expect = 0.0
Identities = 358/687 (52%), Positives = 471/687 (68%), Gaps = 7/687 (1%)
Query: 7 WECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIF 66
WECKA G+P+PTY+WLKNG PL + R+++ G L I VN SDAGMYQCLAENK+G I+
Sbjct: 335 WECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIY 394
Query: 67 SNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERI 126
++AEL ++A P F+ LK+ +V EVVIECKP+ SPKP +WKKG ++EN+RI
Sbjct: 395 ASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRI 454
Query: 127 TISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGES 186
I DG+LRI+N +KSD G Y C N FG+A +L VK+PTR+ + P ++TVGES
Sbjct: 455 AILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGES 514
Query: 187 IVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKY 246
IVL C+ HD SLD+ F W+ G IDF+ +G HFE + Q S+ DLMIRNI L HAG+Y
Sbjct: 515 IVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRY 574
Query: 247 VCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQA 306
C VQT+ D +S A+L+VRGPPGPP V ++EIT++TA LSW P DNHSPI+ Y +QA
Sbjct: 575 GCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQA 634
Query: 307 RTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRT 366
R+PFS+GWQ V TVPE+I G +A V LNPWVEYEFR VA N IG G+PS PS RT
Sbjct: 635 RSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRT 694
Query: 367 EEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLAS 426
EA+P+ P NVSG G + ELVI WE V EE QNG GFGY+VAFRP G W ++ S
Sbjct: 695 NEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTS 754
Query: 427 ADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLS 486
++AS++++R+ESV P +PFEVKVGV+NNKG+GPFS V+ SAE EP+ P + A S+S
Sbjct: 755 SEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVS 814
Query: 487 ATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYH 546
++I V W ++++ GR QG+EV YW+ ++E+ A ++T GN++ +T L+G+ LYH
Sbjct: 815 VSEILVAWKH-IKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYH 873
Query: 547 LAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVK 606
V+AYN AG GP S+ V+ TT+K PPSQ P N+ W S++ L W+ V L NESEV
Sbjct: 874 FTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVV 933
Query: 607 GYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISN 666
GYKV YR S++ VIET K + LP YIIE++ +S+GGDG++S QIR+P S
Sbjct: 934 GYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYS- 992
Query: 667 AYARGSGASTSNACTLSAISTIMISLT 693
G TS TL ++ST S+T
Sbjct: 993 -----GGKITSAQSTLHSLSTSSSSVT 1014
Score = 96.7 bits (239), Expect = 7e-20
Identities = 80/267 (29%), Positives = 115/267 (43%), Gaps = 22/267 (8%)
Query: 8 ECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFS 67
EC A G P PT W+K + ++ R++ Q L I V L DAG+Y+C AEN G
Sbjct: 247 ECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSF 306
Query: 68 NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERIT 127
+L V P + L T + G + ECK P+P Y W K L R+
Sbjct: 307 RGQLQVYTY-PHWVEKL--NDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVE 363
Query: 128 ISEDGNLRIINVTKSDAGSYTCIATNHFGT--ASSTGNLVVKDPTRVMVP-PSSMDVTVG 184
+ +G L I NV +SDAG Y C+A N +G AS+ ++ PT + ++ VT
Sbjct: 364 M-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKD 422
Query: 185 ESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSA---GDLMIRNIQLK 241
+ +V+ C+ S +W + GD R + + G L I N
Sbjct: 423 QEVVIECK--PQGSPKPTISW----------KKGDRAVRENKRIAILPDGSLRILNASKS 470
Query: 242 HAGKYVCMVQTSVDRLSAAADLIVRGP 268
GKYVC + A L V+ P
Sbjct: 471 DEGKYVCRGENVFGSAEIIASLSVKEP 497
Score = 87.0 bits (214), Expect = 5e-17
Identities = 164/729 (22%), Positives = 265/729 (36%), Gaps = 121/729 (16%)
Query: 2 EENVFWECKANGRPKPTYKWLKNGEPL-LTRD-RIQIEQGTLNITIVN-LSDAGMYQCLA 58
E+ V C+ G P P+Y+WL+NG + L D R + GT I+ + D+G YQCLA
Sbjct: 42 EKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLA 101
Query: 59 ENKHGVIFS-NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKA-SPKPVYTW--- 113
N G I S A L +G RT + V+ G VV+ C P SP+ +Y+W
Sbjct: 102 TNTVGSILSREATLQFAYLGNFSGRT--RSAVSVREGQGVVLMCSPPPHSPEIIYSWVFN 159
Query: 114 KKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVM 173
+ + +++ R E GNL I V SD GSY C+ N A RV+
Sbjct: 160 EFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNA------------RVL 207
Query: 174 VPPSSM----DVTVGE-----SIVLPCQVTHDHSLDI------------VFTW-SFNGHL 211
PP+ + D +GE + P VT + TW NG++
Sbjct: 208 SPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYI 267
Query: 212 IDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGP 271
+ + S L I N+QL AG Y C + S + S L V P
Sbjct: 268 P---------SKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHW 318
Query: 272 PEAVTIDEITDTTAQLSW------RPGP-----DNHSPITMYVIQARTPFSVGWQAVSTV 320
E + D D+ + L W +P P N P++ Q+R G + V
Sbjct: 319 VEKLN-DTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSP---QSRVEMVNGVLMIHNV 374
Query: 321 PELIDG--KTFTATVVGLNPWVEYEFRTVA-ANVIGIGEPSRPSEKRRTEEALPEVTPAN 377
+ G + G + E + +A A + + + + +E + E P
Sbjct: 375 NQSDAGMYQCLAENKYGA-IYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQ- 432
Query: 378 VSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNE 437
G K I+W+ ++ + +A P G + + + +D +YV R E
Sbjct: 433 ----GSPKP--TISWKKGDRAVRENKR----IAILPDGSL--RILNASKSDEGKYVCRGE 480
Query: 438 SVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASP 497
+V + + V +P + E +I SL D+ +W
Sbjct: 481 NVFGSAEIIASLSV-KEPTRIELTPKRTELTVGESIVLNCKAIHDASL---DVTFYWT-- 534
Query: 498 LEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGT 557
++G + D EE ++ Q S+ ++ +L H T
Sbjct: 535 -------LKGQPI------DFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTT 581
Query: 558 GPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYR---- 613
S + + PP P I+ ++S L+W A DN S + Y + R
Sbjct: 582 ADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWS--PAADNHSPISSYNLQARSPFS 639
Query: 614 --WNRQSSTSVIETNKTSVELSLPFD-----EDYIIEIKPFSDGGDGSSSEQIR----IP 662
W + I T +++ + E ++ P G + S IR +P
Sbjct: 640 LGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVP 699
Query: 663 KISNAYARG 671
K + G
Sbjct: 700 KTAPTNVSG 708
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 653 bits (1685), Expect = 0.0
Identities = 302/655 (46%), Positives = 436/655 (66%), Gaps = 1/655 (0%)
Query: 4 NVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHG 63
N+ W C A G+P+PT +WL+NGEPL +++R+++ G L + ++L D+GMYQC+AENKHG
Sbjct: 343 NLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHG 402
Query: 64 VIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKEN 123
I+++AEL+V A+ PDF ++R+ GGE++I C+P+A+PK V W KG +IL +
Sbjct: 403 TIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNS 462
Query: 124 ERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTV 183
R+T++ DG L I N+++SD G YTC A N G A+STG L V+D T++ + PSS D+ +
Sbjct: 463 SRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINL 522
Query: 184 GESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHA 243
G+++ L C +HD ++D+ FTW+ + IDFD+ G H+ R +++ GDL I N QL+H
Sbjct: 523 GDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHG 582
Query: 244 GKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYV 303
GKY CM QT VD S A ++VRGPPGPP V + +I DTT QLSW G DNHSPI Y
Sbjct: 583 GKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYT 642
Query: 304 IQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEK 363
+QARTP + W+ V T P I+G TA V+GL PW++YEFR +A+N++G GEPS PS K
Sbjct: 643 LQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSK 702
Query: 364 RRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTV 423
RT EA P V P+ +SGGGG+ EL++ W + E QNG GFGY+++FR G W
Sbjct: 703 IRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTAR 762
Query: 424 LASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFAR 483
+ ADA +V+ NESV P++PFEVK+ +N +G+GP S T +VYSAEEEP P ++A+
Sbjct: 763 VPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAK 822
Query: 484 SLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSV 543
+S++++ V W + G + GYE++YW+ DKE A ++RT G TS +++ L +
Sbjct: 823 GVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNT 882
Query: 544 LYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNES 603
YH+ V+AYN AGTGP+S + N TT KPPP +PPGNI W S S + + WD V NES
Sbjct: 883 KYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNES 942
Query: 604 EVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDY-IIEIKPFSDGGDGSSSE 657
V GYK+LY+ + + ++ T K +E+ +P D + +++I+ GGDG +E
Sbjct: 943 AVTGYKMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAE 997
Score = 101 bits (252), Expect = 2e-21
Identities = 146/681 (21%), Positives = 266/681 (39%), Gaps = 62/681 (9%)
Query: 3 ENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKH 62
+ V EC A G P P KW K L + + TL I V+ D G Y+C AEN
Sbjct: 255 QQVTLECFAFGNPVPRIKWRKVDGSL--SPQWTTAEPTLQIPSVSFEDEGTYECEAENSK 312
Query: 63 GVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKE 122
G + ++ P++ + + T +G + C P+P W + + L
Sbjct: 313 GRDTVQGRI-IVQAQPEWLKVISD--TEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLAS 369
Query: 123 NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVK--------DPTRVMV 174
R+ + G+LR ++ D+G Y C+A N GT ++ L V+ +P R ++
Sbjct: 370 QNRVEVLA-GDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLI 428
Query: 175 PPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLM 234
P + G I++PCQ + V WS ++ + RV G L+
Sbjct: 429 PAAR-----GGEILIPCQPR--AAPKAVVLWSKGTEIL------VNSSRVTVTPD-GTLI 474
Query: 235 IRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPG---PPEAVTIDEITDTTAQLSWRP 291
IRNI GKY C + + + ++ L VR P + I+ + T Q
Sbjct: 475 IRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASH 534
Query: 292 GPDNHSPITMYVIQARTPFSV--GWQAVSTVPELIDGKTFTATVVGLNPWVEY--EFRTV 347
P T + F G + V E I T LN + + ++ +
Sbjct: 535 DPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTI------LNAQLRHGGKYTCM 588
Query: 348 AANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGY 407
A V+ S++ P P V + + ++W + +
Sbjct: 589 AQTVV-----DSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTL 643
Query: 408 VVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEG-PFSPTTVV 466
P GK + T A+ + + + + P+ +E +V N G G P P++ +
Sbjct: 644 QARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKI 703
Query: 467 YSAEEEPTKPPASIFARSLSATDIEVFWASPL--EKNRGRIQGYEVKYWRHEDKEENARK 524
+ E P+ P+ + + ++ V W +P+ E G GY + + R +
Sbjct: 704 RTREAAPSVAPSGLSGGGGAPGELIVNW-TPMSREYQNGDGFGYLLSFRRQGSTHWQTAR 762
Query: 525 IRTVGNQTST-KITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIW- 582
+ Q +++ + + +++YN G GP S T V + + P P +W
Sbjct: 763 VPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTK-VWA 821
Query: 583 -NSSDSKIILNWDQVKALDNESEVKGYKVLYRW---NRQSSTSVIETN--KTSVELS-LP 635
S S++ + W+ V+ D + GY++ Y W +++++ + T TS +S L
Sbjct: 822 KGVSSSEMNVTWEPVQQ-DMNGILLGYEIRY-WKAGDKEAAADRVRTAGLDTSARVSGLH 879
Query: 636 FDEDYIIEIKPFSDGGDGSSS 656
+ Y + ++ ++ G G +S
Sbjct: 880 PNTKYHVTVRAYNRAGTGPAS 900
Score = 77.8 bits (190), Expect = 3e-14
Identities = 84/310 (27%), Positives = 127/310 (40%), Gaps = 39/310 (12%)
Query: 2 EENVFWECKANGRPKPTYKWLKNGEPLLTR--DRIQIEQGTLNITIVN---LSDAGMYQC 56
EE V C+A P TY+W NG + R Q+ G N+ I+N DAG+YQC
Sbjct: 54 EEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGG--NLVIMNPTKAQDAGVYQC 111
Query: 57 LAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKAS-PKPVYTWKK 115
LA N G + S + +FS+ V + G V++ C P A P Y W
Sbjct: 112 LASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHE-GWGVMLPCNPPAHYPGLSYRWLL 170
Query: 116 GR--DILKENERITISED-GNLRIINVTKSDAGSYTCIATNH--FGTAS-----STGNLV 165
+ + + R +S+ GNL I SD G+Y+C+AT+H F T S + NL
Sbjct: 171 NEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLA 230
Query: 166 VKDPTRVMVP------PSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGD 219
+D TR+ P P+ VG+ + L C + I + R D
Sbjct: 231 AED-TRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKW------------RKVD 277
Query: 220 HFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDE 279
+ L I ++ + G Y C + S R + +IV+ P + ++ D
Sbjct: 278 GSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVIS-DT 336
Query: 280 ITDTTAQLSW 289
D + L W
Sbjct: 337 EADIGSNLRW 346
Score = 65.1 bits (157), Expect = 2e-10
Identities = 69/265 (26%), Positives = 111/265 (41%), Gaps = 26/265 (9%)
Query: 15 PKPTYKWLKNGEP--LLTRDRIQIEQGTLNITIV--NLSDAGMYQCLAENKHGV----IF 66
P +Y+WL N P + T R + Q T N+ I N SD G Y CLA + +F
Sbjct: 162 PGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVF 221
Query: 67 SN-AELSVIAVGPDFSRTLLKR----VTLVKVGGEVVIECKPKASPKPVYTWKKGRDILK 121
S A+L++ A +K T VG +V +EC +P P W+K L
Sbjct: 222 SKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLS 281
Query: 122 ENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDV 181
+ + L+I +V+ D G+Y C A N G + G ++V+ + S +
Sbjct: 282 PQ---WTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEA 338
Query: 182 TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK 241
+G ++ C + W NG + RV + AGDL + L+
Sbjct: 339 DIGSNLRWGCAAAGKPRPTV--RWLRNGEPLASQ------NRV--EVLAGDLRFSKLSLE 388
Query: 242 HAGKYVCMVQTSVDRLSAAADLIVR 266
+G Y C+ + + A+A+L V+
Sbjct: 389 DSGMYQCVAENKHGTIYASAELAVQ 413
>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
Length = 1018
Score = 617 bits (1590), Expect = e-176
Identities = 296/654 (45%), Positives = 417/654 (63%), Gaps = 11/654 (1%)
Query: 4 NVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHG 63
+++W C A G+P PT +WLKNG +G L + V +AGMYQC+AEN +G
Sbjct: 347 DLYWPCVATGKPIPTIRWLKNG--------YAYHKGELRLYDVTFENAGMYQCIAENTYG 398
Query: 64 VIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKEN 123
I++NAEL ++A+ P F +K+ L GG V+IECKPKA+PKP ++W KG + L +
Sbjct: 399 AIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNS 458
Query: 124 ERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTV 183
RI I EDG+L I N+T++D G YTC A N+ G A+STG LV+ DPTR+++ P + D+TV
Sbjct: 459 SRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITV 518
Query: 184 GESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHA 243
GE+ + C + D +LD+ F WSFNG++IDF+++ H++R DS G+L+IRN QLKHA
Sbjct: 519 GENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHA 578
Query: 244 GKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYV 303
G+Y C QT VD SA+ADL+VRGPPGPP + I++I T+ L+W G DNHSPI+ Y
Sbjct: 579 GRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYT 638
Query: 304 IQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEK 363
IQ +T S W+ T P +I+G A V L PW+EYEFR VA N +G GEPS PS +
Sbjct: 639 IQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNR 698
Query: 364 RRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTV 423
+T+ A P V P++V GGGG EL ITW + E G FGY+VAF+P+ W
Sbjct: 699 IKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVT 758
Query: 424 LASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFAR 483
+ + D RYV ++E++ P + F+VKV FNNKG+GP+S V+ SA++ P++ P + +
Sbjct: 759 VTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVK 818
Query: 484 SLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSV 543
LS+++I V W LEK ++ Y+++YW DKEE A +++ + S ++ NL
Sbjct: 819 VLSSSEISVHWEHVLEK---IVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDT 875
Query: 544 LYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNES 603
Y + V A NSAG GP S + T+K PPSQPP I S S+ I+ WD V AL NES
Sbjct: 876 QYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNES 935
Query: 604 EVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSE 657
V GYKVLYR + Q + T+K S+E+ +P D +Y++E++ SDGGDG S+
Sbjct: 936 TVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQ 989
Score = 79.0 bits (193), Expect = 1e-14
Identities = 71/275 (25%), Positives = 108/275 (39%), Gaps = 32/275 (11%)
Query: 1 MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN 60
M +NV EC A G P P +W K EP+ + I L I + L D G+Y+C AEN
Sbjct: 255 MGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAEN 314
Query: 61 KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL 120
G A + V A P++ + T V +G ++ C P P W K
Sbjct: 315 IRGKDKHQARIYVQAF-PEWVEHI--NDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAY 371
Query: 121 KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGT--ASSTGNLVVKDPTRVMVPPSS 178
+ G LR+ +VT +AG Y CIA N +G A++ ++ PT M P
Sbjct: 372 HK---------GELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKK 422
Query: 179 MDVTV-GESIVLPCQVTHDHSLDIVFT----WSFNGHLIDFDRDGDHFERVGGQDSAGDL 233
+ G +++ C+ ++ W N I D G L
Sbjct: 423 KILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWED-------------GSL 469
Query: 234 MIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGP 268
I NI G Y C + + + ++ L++ P
Sbjct: 470 EINNITRNDGGIYTCFAENNRGKANSTGTLVITDP 504
Score = 69.3 bits (168), Expect = 1e-11
Identities = 87/307 (28%), Positives = 126/307 (41%), Gaps = 31/307 (10%)
Query: 1 MEENVFWECKANGRPKPTYKW-LKNGEPLLTRDRIQIEQGTLNITIVNLS-DAGMYQCLA 58
+E V C+A P P YKW + NG+ LT DR + G L I + DAG+Y CLA
Sbjct: 57 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 116
Query: 59 ENKHGVIFSN-AELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKAS-PKPV-YTWKK 115
N +G++ S A LS + P F V VK G +V+ C P P + Y W
Sbjct: 117 SNNYGMVRSTEATLSFGYLDP-FPPEERPEVR-VKEGKGMVLLCDPPYHFPDDLSYRWLL 174
Query: 116 GRD---ILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLV--VKDPT 170
I + R +GNL I NV SD G+Y+C ++ T S + + P
Sbjct: 175 NEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPE 234
Query: 171 RVMVP-PSSMDV-------TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFE 222
R P P+ + V +G+++ L C + DI + L +
Sbjct: 235 RTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDI----RWRKVLEPMPSTAEI-- 288
Query: 223 RVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITD 282
S L I NIQL+ G Y C + + A + V+ P E + E+ D
Sbjct: 289 ----STSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEV-D 343
Query: 283 TTAQLSW 289
+ L W
Sbjct: 344 IGSDLYW 350
>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
Length = 1007
Score = 617 bits (1590), Expect = e-176
Identities = 296/654 (45%), Positives = 417/654 (63%), Gaps = 11/654 (1%)
Query: 4 NVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHG 63
+++W C A G+P PT +WLKNG +G L + V +AGMYQC+AEN +G
Sbjct: 336 DLYWPCVATGKPIPTIRWLKNG--------YAYHKGELRLYDVTFENAGMYQCIAENTYG 387
Query: 64 VIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKEN 123
I++NAEL ++A+ P F +K+ L GG V+IECKPKA+PKP ++W KG + L +
Sbjct: 388 AIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNS 447
Query: 124 ERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTV 183
RI I EDG+L I N+T++D G YTC A N+ G A+STG LV+ DPTR+++ P + D+TV
Sbjct: 448 SRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITV 507
Query: 184 GESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHA 243
GE+ + C + D +LD+ F WSFNG++IDF+++ H++R DS G+L+IRN QLKHA
Sbjct: 508 GENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHA 567
Query: 244 GKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYV 303
G+Y C QT VD SA+ADL+VRGPPGPP + I++I T+ L+W G DNHSPI+ Y
Sbjct: 568 GRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYT 627
Query: 304 IQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEK 363
IQ +T S W+ T P +I+G A V L PW+EYEFR VA N +G GEPS PS +
Sbjct: 628 IQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNR 687
Query: 364 RRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTV 423
+T+ A P V P++V GGGG EL ITW + E G FGY+VAF+P+ W
Sbjct: 688 IKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVT 747
Query: 424 LASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFAR 483
+ + D RYV ++E++ P + F+VKV FNNKG+GP+S V+ SA++ P++ P + +
Sbjct: 748 VTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVK 807
Query: 484 SLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSV 543
LS+++I V W LEK ++ Y+++YW DKEE A +++ + S ++ NL
Sbjct: 808 VLSSSEISVHWEHVLEK---IVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDT 864
Query: 544 LYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNES 603
Y + V A NSAG GP S + T+K PPSQPP I S S+ I+ WD V AL NES
Sbjct: 865 QYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNES 924
Query: 604 EVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSE 657
V GYKVLYR + Q + T+K S+E+ +P D +Y++E++ SDGGDG S+
Sbjct: 925 TVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQ 978
Score = 79.0 bits (193), Expect = 1e-14
Identities = 71/275 (25%), Positives = 108/275 (39%), Gaps = 32/275 (11%)
Query: 1 MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN 60
M +NV EC A G P P +W K EP+ + I L I + L D G+Y+C AEN
Sbjct: 244 MGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAEN 303
Query: 61 KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL 120
G A + V A P++ + T V +G ++ C P P W K
Sbjct: 304 IRGKDKHQARIYVQAF-PEWVEHI--NDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAY 360
Query: 121 KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGT--ASSTGNLVVKDPTRVMVPPSS 178
+ G LR+ +VT +AG Y CIA N +G A++ ++ PT M P
Sbjct: 361 HK---------GELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKK 411
Query: 179 MDVTV-GESIVLPCQVTHDHSLDIVFT----WSFNGHLIDFDRDGDHFERVGGQDSAGDL 233
+ G +++ C+ ++ W N I D G L
Sbjct: 412 KILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWED-------------GSL 458
Query: 234 MIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGP 268
I NI G Y C + + + ++ L++ P
Sbjct: 459 EINNITRNDGGIYTCFAENNRGKANSTGTLVITDP 493
Score = 69.3 bits (168), Expect = 1e-11
Identities = 87/307 (28%), Positives = 126/307 (41%), Gaps = 31/307 (10%)
Query: 1 MEENVFWECKANGRPKPTYKW-LKNGEPLLTRDRIQIEQGTLNITIVNLS-DAGMYQCLA 58
+E V C+A P P YKW + NG+ LT DR + G L I + DAG+Y CLA
Sbjct: 46 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 105
Query: 59 ENKHGVIFSN-AELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKAS-PKPV-YTWKK 115
N +G++ S A LS + P F V VK G +V+ C P P + Y W
Sbjct: 106 SNNYGMVRSTEATLSFGYLDP-FPPEERPEVR-VKEGKGMVLLCDPPYHFPDDLSYRWLL 163
Query: 116 GRD---ILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLV--VKDPT 170
I + R +GNL I NV SD G+Y+C ++ T S + + P
Sbjct: 164 NEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPE 223
Query: 171 RVMVP-PSSMDV-------TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFE 222
R P P+ + V +G+++ L C + DI + L +
Sbjct: 224 RTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDI----RWRKVLEPMPSTAEI-- 277
Query: 223 RVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITD 282
S L I NIQL+ G Y C + + A + V+ P E + E+ D
Sbjct: 278 ----STSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEV-D 332
Query: 283 TTAQLSW 289
+ L W
Sbjct: 333 IGSDLYW 339
>gi|28373124 contactin 4 isoform b precursor [Homo sapiens]
Length = 282
Score = 563 bits (1452), Expect = e-160
Identities = 282/282 (100%), Positives = 282/282 (100%)
Query: 417 MIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKP 476
MIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKP
Sbjct: 1 MIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKP 60
Query: 477 PASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKI 536
PASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKI
Sbjct: 61 PASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKI 120
Query: 537 TNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQV 596
TNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQV
Sbjct: 121 TNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQV 180
Query: 597 KALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSS 656
KALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSS
Sbjct: 181 KALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSS 240
Query: 657 EQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL 698
EQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL
Sbjct: 241 EQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL 282
>gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo
sapiens]
Length = 1183
Score = 269 bits (688), Expect = 6e-72
Identities = 208/692 (30%), Positives = 310/692 (44%), Gaps = 61/692 (8%)
Query: 9 CKANGRPKPTYKWLKNGEPL-LTRD--RIQIEQGTLNITIVNLSDAGMYQCLAENKHGVI 65
C+ANG PKP WL NG P+ + D +I+ T+ + V + +YQC A N++G +
Sbjct: 376 CRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYL 435
Query: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTWKKGRDILKEN 123
+NA ++V+A P R L TL +V +++C SP P W KG +
Sbjct: 436 LANAFVNVLAEPP---RILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALH 492
Query: 124 ERI-TISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVT 182
E I + E+G L I K G+YTC+A N G A + +L +KDPT ++ P V
Sbjct: 493 EDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQ 552
Query: 183 VGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDR----DGDHFERVGGQDSAGDLMIRNI 238
G + C+V HDH+L + W + + D D DH L++ ++
Sbjct: 553 RGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDH------------LVVADV 600
Query: 239 QLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSP 298
+G Y C+ T++D +SA+A L V P PP + + + D + QLSW PG DN+SP
Sbjct: 601 SDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSP 660
Query: 299 ITMYVIQARTPFSVG--WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGE 356
IT ++I+ W + V T T + L+P+V Y FR +A N IG
Sbjct: 661 ITKFIIEYEDAMHKPGLWHHQTEV-----SGTQTTAQLKLSPYVNYSFRVMAVNSIGKSL 715
Query: 357 PSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPY-G 415
PS SE+ T+ + P+ P V G G LVITW+ + NG G Y V++R G
Sbjct: 716 PSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDG 775
Query: 416 KMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTK 475
W T + A+ S+Y+ F P+ +KV N+ G P + +S E+ P
Sbjct: 776 DDEW--TSVVVANVSKYIV--SGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMV 831
Query: 476 PPASIFARSLSATDIEVFW-ASPLEKNRGRIQGYEVKYWRHEDKEENAR-----KIRTV- 528
P ++ +++T EV W PL+ RG +QGY + YW+ + + R KI T
Sbjct: 832 APGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQ 891
Query: 529 GNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSK 588
G++T + L+ Y L V+ N G GP+S T + PS P I N +
Sbjct: 892 GSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDS 951
Query: 589 IILNWDQVKALDNESEVKGYKVLYRWNRQSSTSV----------IETNKTSVEL-SLPFD 637
+ L WD S G Y Q S I NKT L +L F
Sbjct: 952 LTLEWDP------PSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFS 1005
Query: 638 EDYIIEIKPFSDGGDGSSSEQIRIPKISNAYA 669
Y + G GS + + + A A
Sbjct: 1006 TRYKFYFYAQTSAGSGSQITEEAVTTVDEAMA 1037
Score = 115 bits (289), Expect = 1e-25
Identities = 150/607 (24%), Positives = 240/607 (39%), Gaps = 90/607 (14%)
Query: 8 ECKANGRPKPTYKWLKNGEPLLTRDRIQI--EQGTLNITIVNLSDAGMYQCLAENKHGVI 65
+C G P PT +W K + + I + E GTL I + G Y C+A NK G+
Sbjct: 469 DCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMA 528
Query: 66 FSNAELSV-----IAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYT--WKKGRD 118
+ L + I P+++ +V+ G V ECK K T W K
Sbjct: 529 KNEVHLEIKDPTWIVKQPEYA--------VVQRGSMVSFECKVKHDHTLSLTVLWLKDNR 580
Query: 119 ILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSS 178
L +ER T+ +D +L + +V+ D+G+YTC+A + S++ L V D V PP
Sbjct: 581 ELPSDERFTVDKD-HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVD---VPNPPFD 636
Query: 179 MDVT--VGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFD----RDG--DHFERVGGQDSA 230
+++T + +S+ L D++ I +I+++ + G H V G +
Sbjct: 637 LELTDQLDKSVQLSWTPGDDNNSPI------TKFIIEYEDAMHKPGLWHHQTEVSGTQTT 690
Query: 231 GDLMI--------RNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITD 282
L + R + + GK + + S L+ A++ P P AV
Sbjct: 691 AQLKLSPYVNYSFRVMAVNSIGKSL-PSEASEQYLTKASE-----PDKNPTAVEGLGSEP 744
Query: 283 TTAQLSWRP--GPDNHSPITMYVIQARTPFSVGWQAVSTVPE---LIDGKTFTATVVGLN 337
++W+P G +++ P Y V W+ E ++ V G
Sbjct: 745 DNLVITWKPLNGFESNGPGLQY--------KVSWRQKDGDDEWTSVVVANVSKYIVSGTP 796
Query: 338 PWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPE 397
+V Y + A N +G P + E LP V P NV + + + W+ VP
Sbjct: 797 TFVPYLIKVQALNDMGFA-PEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPL 855
Query: 398 ELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYV------FRNESVH-------PFSP 444
+ G GY ++ + T +S R++ F+ H PFS
Sbjct: 856 KSIRGHLQGY--------RIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSH 907
Query: 445 FEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPA-SIFARSLSATDIEVFWASPLEKNRG 503
+ + V V N KGEGP SP V + E P+ P + I +L + +E W P N G
Sbjct: 908 YTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLE--WDPPSHPN-G 964
Query: 504 RIQGYEVKYWRHEDKEENAR--KIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSS 561
+ Y +KY E ++ N+T + NL S Y A SAG+G
Sbjct: 965 ILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQI 1024
Query: 562 ATVNVTT 568
VTT
Sbjct: 1025 TEEAVTT 1031
Score = 71.6 bits (174), Expect = 2e-12
Identities = 55/180 (30%), Positives = 89/180 (49%), Gaps = 19/180 (10%)
Query: 3 ENVFWECKANGRPKPTYKWLKNG-------EPLLTRDRIQIEQGTLNITIVNLSDA---- 51
EN+ +C+A G+P P++ W +NG +PL+T ++ GTL I I++ A
Sbjct: 56 ENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVT---MKPGTGTLIINIMSEGKAETYE 112
Query: 52 GMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKAS-PKPV 110
G+YQC A N+ G SN + + P +++ L+ +TL + G +V+ C+P P P+
Sbjct: 113 GVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITL-QSGQSLVLPCRPPIGLPPPI 171
Query: 111 YTWKKGR-DILKENERITISEDGNLRIINVTKSDA-GSYTCIAT-NHFGTASSTGNLVVK 167
W L ++ER++ +G+L NV D Y C A NH T + VK
Sbjct: 172 IFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVK 231
Score = 63.5 bits (153), Expect = 6e-10
Identities = 46/176 (26%), Positives = 81/176 (46%), Gaps = 7/176 (3%)
Query: 94 GGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATN 153
G + +EC + P P+ W K +L +N + + + L+II+V+++D+G+Y CIA N
Sbjct: 279 GNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKN 338
Query: 154 HFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLID 213
G T ++ VK + P ++ ++ GE L C+ + I +W NG I+
Sbjct: 339 ALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRI--SWLTNGVPIE 396
Query: 214 FDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP 269
D D ++ G ++ N+Q + + Y C L A A + V P
Sbjct: 397 IAPD-DPSRKIDGD----TIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEP 447
Score = 59.3 bits (142), Expect = 1e-08
Identities = 53/196 (27%), Positives = 89/196 (45%), Gaps = 22/196 (11%)
Query: 8 ECKANGRPKPTYKWLKNGEPLLTRDRIQIE--QGTLNITIVNLSDAGMYQCLAENKHGVI 65
EC A G P P W K + +L ++R + + TL I V+ +D+G YQC+A+N G I
Sbjct: 285 ECIAEGLPTPIIYWAKE-DGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAI 343
Query: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENER 125
+ +SV + T + + L G + + C+ +PKP +W L
Sbjct: 344 --HHTISVRVKAAPYWITAPQNLVL-SPGEDGTLICRANGNPKPRISW------LTNGVP 394
Query: 126 ITISEDGNLRII--------NVTKSDAGSYTCIATNHFGTASSTGNL-VVKDPTRVMVPP 176
I I+ D R I NV + + Y C A+N +G + + V+ +P R++ P
Sbjct: 395 IEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPA 454
Query: 177 SSM-DVTVGESIVLPC 191
+++ V +L C
Sbjct: 455 NTLYQVIANRPALLDC 470
>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
[Homo sapiens]
Length = 1224
Score = 268 bits (684), Expect = 2e-71
Identities = 183/627 (29%), Positives = 293/627 (46%), Gaps = 46/627 (7%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNL--SDAGMYQCLAENKHGVIF 66
C+A G P+PT KW NG P+ I+ NL + +YQC A N HG I
Sbjct: 368 CEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTIL 427
Query: 67 SNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILK-ENER 125
+NA + V+ V P + V VG + C+ ASP+ V +W+K ++ E R
Sbjct: 428 ANANIDVVDVRPLIQTKDGENYATV-VGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRR 486
Query: 126 ITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGE 185
I E+G L+I T+ DAGSY+C N G + T NL +++ T++ V P + +
Sbjct: 487 YHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLH 546
Query: 186 SIVLPCQVTHDHSL--DIVFTWSFNGHLIDFDRDGDHFERVGGQDS-----AGDLMIRNI 238
+ L C+ D L + +WS +DG+ FE G +D +L I N+
Sbjct: 547 MLELHCESKCDSHLKHSLKLSWS---------KDGEAFEINGTEDGRIIIDGANLTISNV 597
Query: 239 QLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSP 298
L+ G Y C T++D + + V P PPE + + E + + +L+W G D++S
Sbjct: 598 TLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSN 657
Query: 299 ITMYVIQARTPFSVGWQAVSTVPEL--IDGKTFTATVVGLNPWVEYEFRTVAANVIGIGE 356
I+ Y+++ F + EL + GK T ++ L P+V Y+FR +A N +G +
Sbjct: 658 ISEYIVE----FEGNKEEPGRWEELTRVQGKK-TTVILPLAPFVRYQFRVIAVNEVGRSQ 712
Query: 357 PSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGK 416
PS+PS+ T A P+ P N+ E++I WE + QNG G Y V ++P G
Sbjct: 713 PSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGA 772
Query: 417 MI-WMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTK 475
+ W + + R + ++P++VKV N G GP + +YS E+ P
Sbjct: 773 PVEW-----EEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDT 827
Query: 476 PPASIFARSLSATDIEVFWAS-PLEKNRGRIQGYEVKYW--------RHEDKEENARKIR 526
P +++T ++V W++ P ++ GR++GY++ +W R KE N +R
Sbjct: 828 APVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNI--LR 885
Query: 527 TVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSD 586
G + S + +L +HL V AYNS G GP S T + P QP +
Sbjct: 886 FSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDK 945
Query: 587 SKIILNWDQVKALDNESEVKGYKVLYR 613
L+W K L+ + GY + Y+
Sbjct: 946 DTATLSWGLPKKLN--GNLTGYLLQYQ 970
Score = 73.9 bits (180), Expect = 5e-13
Identities = 69/304 (22%), Positives = 122/304 (40%), Gaps = 54/304 (17%)
Query: 8 ECKANGRPKPTYKWLKNGEPL-LTRDRIQIEQGTLNITIVNLSD----AGMYQCLAENKH 62
EC+A G P+PT+ W K+G P T RI + I N G Y+C A NK
Sbjct: 56 ECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKL 115
Query: 63 GVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDI--L 120
G+ S ++ P F + + + V+ G +V+ C P P++ + ++ +
Sbjct: 116 GIAMSEEIEFIVPSVPKFPKEKIDPLE-VEEGDPIVLPCNPPKGLPPLHIYWMNIELEHI 174
Query: 121 KENERITISEDGNLRIINVTKSDA-GSYTCIAT--------------------NHFGTAS 159
+++ER+ +S+ G+L NV + D+ Y C A H +S
Sbjct: 175 EQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSS 234
Query: 160 ST------GNLVVKDPTRVMVPP------SSMDVTVGESIVLPCQVTHDHSLDIVFTWSF 207
S+ N + + ++++PP SS+ + GE ++L C F
Sbjct: 235 SSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLEC-----------FAEGL 283
Query: 208 NGHLIDFDRDGDHFE--RVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIV 265
+D+++ G R ++ L I N+ + G Y C + + +IV
Sbjct: 284 PTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIV 343
Query: 266 RGPP 269
PP
Sbjct: 344 EEPP 347
Score = 68.9 bits (167), Expect = 1e-11
Identities = 136/638 (21%), Positives = 230/638 (36%), Gaps = 61/638 (9%)
Query: 3 ENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQG-TLNITIVNLSDAGMYQCLAENK 61
E + EC A G P P W K G L + G TL I V+ D G Y+C A N
Sbjct: 272 EILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNF 331
Query: 62 HGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWK-KGRDIL 120
G + + VI P T + + G ++ C+ + P+P W+ G +
Sbjct: 332 LGT--ATHDFHVIVEEPP-RWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVD 388
Query: 121 KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD--PTRVMVPPSS 178
+ + N+ + Y C A+N GT + N+ V D P +
Sbjct: 389 NHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGEN 448
Query: 179 MDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNI 238
VG S L C+ S + V +W + + H G L I
Sbjct: 449 YATVVGYSAFLHCEFF--ASPEAVVSWQKVEEVKPLEGRRYHIY------ENGTLQINRT 500
Query: 239 QLKHAGKYVCMVQTSVDRLSAAADLIVRGPPG---PPEAVTIDEITDTTAQLSWRPGPDN 295
+ AG Y C V+ ++ + + A+L +R P+ I ++ +L D+
Sbjct: 501 TEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKL--HMLELHCESKCDS 558
Query: 296 HSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEY--------EFRTV 347
H ++ + ++ + +IDG T + V L Y +
Sbjct: 559 HLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAAD 618
Query: 348 AANVIGIGEPSRPSEKRRTEEALPEVTPANVSGG--GGSKSELVITWETVPEELQNGRGF 405
V + P P +E V +G + SE ++ +E EE GR
Sbjct: 619 ITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEE--PGR-- 674
Query: 406 GYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEG-PFSPTT 464
+ R GK ++ LA PF ++ +V N G P P+
Sbjct: 675 -WEELTRVQGKKTTVILPLA---------------PFVRYQFRVIAVNEVGRSQPSQPSD 718
Query: 465 VVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKY-WRHEDKEENAR 523
+ P + P +I ++ ++ + W PL+ G E + W+ +
Sbjct: 719 HHETPPAAPDRNPQNIRVQASQPKEMIIKW-EPLKSMEQNGPGLEYRVTWKPQGAPVEWE 777
Query: 524 KIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPP---GNI 580
+ TV N T +T + Y + V+A N G+GP +V + + + P P G
Sbjct: 778 E-ETVTNHTLRVMTPAVYAP-YDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVD 835
Query: 581 IWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQS 618
+ NS+ K+ W V +KGY++ + W +S
Sbjct: 836 VINSTLVKV--TWSTVPKDRVHGRLKGYQINW-WKTKS 870
Score = 61.6 bits (148), Expect = 2e-09
Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 9/178 (5%)
Query: 88 VTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSY 147
+T++K G +++EC + P P W K L + + L+I NV+ D G+Y
Sbjct: 266 ITILK-GEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNY 324
Query: 148 TCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSF 207
C A+N GTA+ +++V++P R P S + G + +L C+ + I W
Sbjct: 325 RCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTI--KWRV 382
Query: 208 NGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIV 265
NG + D+ G ++ N+Q H Y C + A A++ V
Sbjct: 383 NGSPV------DNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDV 434
Score = 45.4 bits (106), Expect = 2e-04
Identities = 48/159 (30%), Positives = 67/159 (42%), Gaps = 19/159 (11%)
Query: 99 IECKPKASPKPVYTW-KKGRDILKENERITISED-GNLRIINV--TKSDAGSYTCIATNH 154
IEC+ K +P+P ++W K G + RI S + G RI N G Y C A+N
Sbjct: 55 IECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNK 114
Query: 155 FGTASSTG-----NLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNG 209
G A S V K P + P ++V G+ IVLPC L + + N
Sbjct: 115 LGIAMSEEIEFIVPSVPKFPKEKIDP---LEVEEGDPIVLPC--NPPKGLPPLHIYWMNI 169
Query: 210 HLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVC 248
L ++D ERV GDL N++ K + C
Sbjct: 170 ELEHIEQD----ERV-YMSQKGDLYFANVEEKDSRNDYC 203
>gi|81158226 neuronal cell adhesion molecule isoform A precursor
[Homo sapiens]
Length = 1304
Score = 265 bits (676), Expect = 1e-70
Identities = 191/616 (31%), Positives = 288/616 (46%), Gaps = 54/616 (8%)
Query: 9 CKANGRPKPTYKWLKNGEPL-LTRD--RIQIEQGTLNITIVNLSDAGMYQCLAENKHGVI 65
C+ANG PKP WL NG P+ + D +I+ T+ + V + +YQC A N++G +
Sbjct: 382 CRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYL 441
Query: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTWKKGRDILKEN 123
+NA ++V+A P R L TL +V +++C SP P W KG +
Sbjct: 442 LANAFVNVLAEPP---RILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALH 498
Query: 124 ERI-TISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVT 182
E I + E+G L I K G+YTC+A N G A + +L +KDPT ++ P V
Sbjct: 499 EDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQ 558
Query: 183 VGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDR----DGDHFERVGGQDSAGDLMIRNI 238
G + C+V HDH+L + W + + D D DH L++ ++
Sbjct: 559 RGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDH------------LVVADV 606
Query: 239 QLKHAGKYVCMVQTSVDRLSAAADLIVRGP----------PGPPEAVTIDEITDTTAQLS 288
+G Y C+ T++D +SA+A L V P P PP + + + D + QLS
Sbjct: 607 SDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLS 666
Query: 289 WRPGPDNHSPITMYVIQARTPFSVG--WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRT 346
W PG DN+SPIT ++I+ W + V T T + L+P+V Y FR
Sbjct: 667 WTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEV-----SGTQTTAQLKLSPYVNYSFRV 721
Query: 347 VAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFG 406
+A N IG PS SE+ T+ + P+ P V G G LVITW+ + NG G
Sbjct: 722 MAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQ 781
Query: 407 YVVAFRPY-GKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTV 465
Y V++R G W T + A+ S+Y+ F P+ +KV N+ G P +
Sbjct: 782 YKVSWRQKDGDDEW--TSVVVANVSKYIV--SGTPTFVPYLIKVQALNDMGFAPEPAVVM 837
Query: 466 VYSAEEEPTKPPASIFARSLSATDIEVFW-ASPLEKNRGRIQGYEVKYWRHEDKEENAR- 523
+S E+ P P ++ +++T EV W PL+ RG +QGY + YW+ + + R
Sbjct: 838 GHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRR 897
Query: 524 ----KIRTV-GNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPG 578
KI T G++T + L+ Y L V+ N G GP+S T + PS P
Sbjct: 898 HIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSS 957
Query: 579 NIIWNSSDSKIILNWD 594
I N + + L WD
Sbjct: 958 LKIVNPTLDSLTLEWD 973
Score = 115 bits (289), Expect = 1e-25
Identities = 153/623 (24%), Positives = 243/623 (39%), Gaps = 94/623 (15%)
Query: 8 ECKANGRPKPTYKWLKNGEPLLTRDRIQI--EQGTLNITIVNLSDAGMYQCLAENKHGVI 65
+C G P PT +W K + + I + E GTL I + G Y C+A NK G+
Sbjct: 475 DCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMA 534
Query: 66 FSNAELSV-----IAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYT--WKKGRD 118
+ L + I P+++ +V+ G V ECK K T W K
Sbjct: 535 KNEVHLEIKDPTWIVKQPEYA--------VVQRGSMVSFECKVKHDHTLSLTVLWLKDNR 586
Query: 119 ILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPT-------R 171
L +ER T+ +D +L + +V+ D+G+YTC+A + S++ L V PT
Sbjct: 587 ELPSDERFTVDKD-HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYD 645
Query: 172 VMVPPSSMDVT--VGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFD----RDG--DHFER 223
V PP +++T + +S+ L D++ I +I+++ + G H
Sbjct: 646 VPNPPFDLELTDQLDKSVQLSWTPGDDNNSPI------TKFIIEYEDAMHKPGLWHHQTE 699
Query: 224 VGGQDSAGDLMI--------RNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAV 275
V G + L + R + + GK + + S L+ A++ P P AV
Sbjct: 700 VSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSL-PSEASEQYLTKASE-----PDKNPTAV 753
Query: 276 TIDEITDTTAQLSWRP--GPDNHSPITMYVIQARTPFSVGWQAVSTVPE---LIDGKTFT 330
++W+P G +++ P Y V W+ E ++
Sbjct: 754 EGLGSEPDNLVITWKPLNGFESNGPGLQY--------KVSWRQKDGDDEWTSVVVANVSK 805
Query: 331 ATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVI 390
V G +V Y + A N +G P + E LP V P NV + + +
Sbjct: 806 YIVSGTPTFVPYLIKVQALNDMGFA-PEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEV 864
Query: 391 TWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYV------FRNESVH---- 440
W+ VP + G GY ++ + T +S R++ F+ H
Sbjct: 865 HWDPVPLKSIRGHLQGY--------RIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLP 916
Query: 441 ---PFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPA-SIFARSLSATDIEVFWAS 496
PFS + + V V N KGEGP SP V + E P+ P + I +L + +E W
Sbjct: 917 GLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLE--WDP 974
Query: 497 PLEKNRGRIQGYEVKYWRHEDKEENAR--KIRTVGNQTSTKITNLKGSVLYHLAVKAYNS 554
P N G + Y +KY E ++ N+T + NL S Y A S
Sbjct: 975 PSHPN-GILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTS 1033
Query: 555 AGTGPSSATVNVTTRKPPPSQPP 577
AG+G VTT PP
Sbjct: 1034 AGSGSQITEEAVTTVDEAGILPP 1056
Score = 71.6 bits (174), Expect = 2e-12
Identities = 55/180 (30%), Positives = 89/180 (49%), Gaps = 19/180 (10%)
Query: 3 ENVFWECKANGRPKPTYKWLKNG-------EPLLTRDRIQIEQGTLNITIVNLSDA---- 51
EN+ +C+A G+P P++ W +NG +PL+T ++ GTL I I++ A
Sbjct: 62 ENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVT---MKPGTGTLIINIMSEGKAETYE 118
Query: 52 GMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKAS-PKPV 110
G+YQC A N+ G SN + + P +++ L+ +TL + G +V+ C+P P P+
Sbjct: 119 GVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITL-QSGQSLVLPCRPPIGLPPPI 177
Query: 111 YTWKKGR-DILKENERITISEDGNLRIINVTKSDA-GSYTCIAT-NHFGTASSTGNLVVK 167
W L ++ER++ +G+L NV D Y C A NH T + VK
Sbjct: 178 IFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVK 237
Score = 63.5 bits (153), Expect = 6e-10
Identities = 46/176 (26%), Positives = 81/176 (46%), Gaps = 7/176 (3%)
Query: 94 GGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATN 153
G + +EC + P P+ W K +L +N + + + L+II+V+++D+G+Y CIA N
Sbjct: 285 GNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKN 344
Query: 154 HFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLID 213
G T ++ VK + P ++ ++ GE L C+ + I +W NG I+
Sbjct: 345 ALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRI--SWLTNGVPIE 402
Query: 214 FDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP 269
D D ++ G ++ N+Q + + Y C L A A + V P
Sbjct: 403 IAPD-DPSRKIDGD----TIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEP 453
Score = 59.3 bits (142), Expect = 1e-08
Identities = 53/196 (27%), Positives = 89/196 (45%), Gaps = 22/196 (11%)
Query: 8 ECKANGRPKPTYKWLKNGEPLLTRDRIQIE--QGTLNITIVNLSDAGMYQCLAENKHGVI 65
EC A G P P W K + +L ++R + + TL I V+ +D+G YQC+A+N G I
Sbjct: 291 ECIAEGLPTPIIYWAKE-DGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAI 349
Query: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENER 125
+ +SV + T + + L G + + C+ +PKP +W L
Sbjct: 350 --HHTISVRVKAAPYWITAPQNLVL-SPGEDGTLICRANGNPKPRISW------LTNGVP 400
Query: 126 ITISEDGNLRII--------NVTKSDAGSYTCIATNHFGTASSTGNL-VVKDPTRVMVPP 176
I I+ D R I NV + + Y C A+N +G + + V+ +P R++ P
Sbjct: 401 IEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPA 460
Query: 177 SSM-DVTVGESIVLPC 191
+++ V +L C
Sbjct: 461 NTLYQVIANRPALLDC 476
Score = 55.1 bits (131), Expect = 2e-07
Identities = 45/183 (24%), Positives = 79/183 (43%), Gaps = 6/183 (3%)
Query: 441 PFSPFEVKVGVFNNKGEGPFSPTTVVYSAE-EEPTKPPASIFARSLSATDIEVFWASPLE 499
P+ + +V N+ G+ S + Y + EP K P ++ ++ + W PL
Sbjct: 713 PYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITW-KPLN 771
Query: 500 KNRGRIQGYEVKY-WRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTG 558
G + K WR +D ++ + V N + ++ V Y + V+A N G
Sbjct: 772 GFESNGPGLQYKVSWRQKDGDDEWTSV-VVANVSKYIVSGTPTFVPYLIKVQALNDMGFA 830
Query: 559 PSSATVNVTTRKPPPSQPPGNIIWNSSDSKII-LNWDQVKALDNESEVKGYKVLYRWNRQ 617
P A V + + P PGN+ N +S + ++WD V ++GY++ Y W Q
Sbjct: 831 PEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYY-WKTQ 889
Query: 618 SST 620
SS+
Sbjct: 890 SSS 892
Score = 29.6 bits (65), Expect = 9.9
Identities = 42/198 (21%), Positives = 71/198 (35%), Gaps = 12/198 (6%)
Query: 267 GPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDG 326
G P P ++ I T + L W P + +T Y ++ + P + + V I
Sbjct: 950 GVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQ-PINSTHELGPLVDLKIPA 1008
Query: 327 KTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEA---LPEVTPANVSGGGG 383
T+ LN Y+F A G G +EA P+V V
Sbjct: 1009 NKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNP 1068
Query: 384 SKSELVI----TWETVPEELQNGRGFGYVVAFRPYG-KMIWMLTVLASADASRYVFRNES 438
S L T+ + E + + V + G K W ++ + SR F +
Sbjct: 1069 RISNLTAAAAETYANISWEYEGPEHVNFYVEYGVAGSKEEWRKEIV---NGSRSFFGLKG 1125
Query: 439 VHPFSPFEVKVGVFNNKG 456
+ P + ++V+VG + G
Sbjct: 1126 LMPGTAYKVRVGAVGDSG 1143
>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
Length = 1174
Score = 264 bits (675), Expect = 2e-70
Identities = 187/603 (31%), Positives = 285/603 (47%), Gaps = 39/603 (6%)
Query: 9 CKANGRPKPTYKWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVI 65
C+ANG PKPT +W+ NGEPL + ++ T+ +S +YQC N+HG +
Sbjct: 369 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL 428
Query: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-KKGRDILKE 122
+NA +SV+ V P R L R L++V ++C SP P W K G+ +
Sbjct: 429 LANAFVSVLDVPP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD 485
Query: 123 NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVT 182
+ E+G+L I + K D G YTC+ATN G A + L VKDPTR+ P
Sbjct: 486 GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAR 545
Query: 183 VGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKH 242
G ++ L C+V HD SL + +W + D R+ +D + L I + +
Sbjct: 546 RGTTVQLECRVKHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LTIFGVAERD 597
Query: 243 AGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMY 302
G Y C+ T +D+ A A L V G P P + + ++ + + +L+W PG N+SPIT Y
Sbjct: 598 QGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDY 657
Query: 303 VIQ-ARTPFSVG-WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRP 360
V+Q F G W S P ++ + V+ L+P+V Y+FR +A N +G PS P
Sbjct: 658 VVQFEEDQFQPGVWHDHSKYPGSVN-----SAVLRLSPYVNYQFRVIAINEVGSSHPSLP 712
Query: 361 SEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAF-RPYGKMIW 419
SE+ RT A PE P +V G G K+ + ITW + G Y+V + R + W
Sbjct: 713 SERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAW 772
Query: 420 -MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPA 478
+TV SRYV V + P+E++V N+ G+GP + + YS E+ P P
Sbjct: 773 NNVTVW----GSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPT 826
Query: 479 SIFARSLSATDIEVFWASPLEKN-RGRIQGYEVKYWRHEDKEEN------ARKIRTVGNQ 531
+ R +++T I + W +G+++ Y YWR +N ++ G++
Sbjct: 827 EVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDR 886
Query: 532 TSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIIL 591
++ L Y L + N G GP S T TT + PS P + + I L
Sbjct: 887 LRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINL 946
Query: 592 NWD 594
WD
Sbjct: 947 EWD 949
Score = 85.9 bits (211), Expect = 1e-16
Identities = 150/688 (21%), Positives = 252/688 (36%), Gaps = 86/688 (12%)
Query: 8 ECKANGRPKPTYKWLKNGEPLLTRDRIQIEQ--GTLNITIVNLSDAGMYQCLAENKHGVI 65
EC A+G P P W K G L + D+ + E L IT V+ D+G Y CLA NK G I
Sbjct: 278 ECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSI 336
Query: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWK-KGRDILKENE 124
+ V A + ++ G + + C+ +PKP W G +
Sbjct: 337 RHTISVRVKAAPYWLDE---PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP 393
Query: 125 RITISEDGNLRIINVTK-SDAGSYTCIATNHFGTASSTGNLVVKD-PTRVMVPPSSM-DV 181
G+ I T+ S Y C +N G + + V D P R++ P + + V
Sbjct: 394 NPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRV 453
Query: 182 TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK 241
+ L C S W NG + D H G L I+ I+ +
Sbjct: 454 ILYNRTRLDCPFF--GSPIPTLRWFKNGQGSNLDGGNYHVY------ENGSLEIKMIRKE 505
Query: 242 HAGKYVCMVQTSVDRLSAAADLIVRGPP---GPPEAVTIDEIT--DTTAQLSWRPGPDNH 296
G Y C+ + + L V+ P PE D++ TT QL R D
Sbjct: 506 DQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE----DQVARRGTTVQLECRVKHDPS 561
Query: 297 SPITMYVIQARTPFSVGWQ--------AVSTVPELIDGKTFTATVVGLNPWVEYEFRTVA 348
+T+ ++ P +G + + V E G L+ + + TV
Sbjct: 562 LKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV- 620
Query: 349 ANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYV 408
+G P RP + T+ A + + +TW +P + N YV
Sbjct: 621 -----LGRPDRPRDLELTDLA---------------ERSVRLTW--IPGDANNSPITDYV 658
Query: 409 VAFR--PYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEG-PFSPTTV 465
V F + +W + V R + P+ ++ +V N G P P+
Sbjct: 659 VQFEEDQFQPGVWHDHSKYPGSVNSAVLR---LSPYVNYQFRVIAINEVGSSHPSLPSER 715
Query: 466 VYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKY---WRHEDKEENA 522
++ P P + ++E+ W +P+ N G ++Y WR + E
Sbjct: 716 YRTSGAPPESNPGDVKGEGTRKNNMEITW-TPM--NATSAFGPNLRYIVKWRRRETREAW 772
Query: 523 RKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNI-I 581
+ G++ T + V Y + V+A N G GP +V + + P P + +
Sbjct: 773 NNVTVWGSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKV 830
Query: 582 WNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFD---- 637
+ + I L W++V + + +++ Y+ Y W S + ++ + S P D
Sbjct: 831 RVMNSTAISLQWNRVYSDTVQGQLREYRAYY-WRESSLLKNLWVSQKRQQASFPGDRLRG 889
Query: 638 --------EDYIIEIKPFSDGGDGSSSE 657
+Y +E+ + GDG SE
Sbjct: 890 VVSRLFPYSNYKLEMVVVNGRGDGPRSE 917
Score = 63.9 bits (154), Expect = 5e-10
Identities = 72/308 (23%), Positives = 119/308 (38%), Gaps = 51/308 (16%)
Query: 3 ENVFWECKANGRPKPTYKWLKNGE--PLLTRDRIQIEQGTLNITIVNLSDA------GMY 54
+N+ EC+A G P P++ W +N + R+ + + + + I S G Y
Sbjct: 51 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110
Query: 55 QCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKAS-PKPVYTW 113
QC A NK G SN ++ P + + L V +V+ G + ++C P P PV W
Sbjct: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV-VVQEGAPLTLQCNPPPGLPSPVIFW 169
Query: 114 -KKGRDILKENERITISEDGNLRIINVTKSDAGS-YTC-------------------IAT 152
+ + +++R++ +G+L NV D + Y+C + T
Sbjct: 170 MSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT 229
Query: 153 NHFGTASSTGNL--------VVKDPTRVMVP---PSSMDVTVGESIVLPCQVTHDHSLDI 201
NH SS N V + M P SS V G ++L C + + DI
Sbjct: 230 NHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 289
Query: 202 VFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAA 261
W G D D FE L I N+ + +G+Y C+ + +
Sbjct: 290 --AWYKKGG--DLPSDKAKFENFNKA-----LRITNVSEEDSGEYFCLASNKMGSIRHTI 340
Query: 262 DLIVRGPP 269
+ V+ P
Sbjct: 341 SVRVKAAP 348
Score = 53.9 bits (128), Expect = 5e-07
Identities = 47/182 (25%), Positives = 80/182 (43%), Gaps = 11/182 (6%)
Query: 90 LVKVGGEVVIECKPKASPKPVYTW-KKGRDILKENERITISEDGNLRIINVTKSDAGSYT 148
+V G ++++EC P P W KKG D+ + + + + LRI NV++ D+G Y
Sbjct: 268 MVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYF 326
Query: 149 CIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFN 208
C+A+N G+ T ++ VK + P ++ + GE L C+ + + W N
Sbjct: 327 CLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTV--QWMVN 384
Query: 209 GHLIDFDRDGDHFERVGGQDSAGDLMI-RNIQLKHAGKYVCMVQTSVDRLSAAADLIVRG 267
G + + ++ AGD +I R+ Q+ Y C L A A + V
Sbjct: 385 GEPLQSAPPNPN------REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLD 438
Query: 268 PP 269
P
Sbjct: 439 VP 440
>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
Length = 1169
Score = 264 bits (675), Expect = 2e-70
Identities = 187/603 (31%), Positives = 285/603 (47%), Gaps = 39/603 (6%)
Query: 9 CKANGRPKPTYKWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVI 65
C+ANG PKPT +W+ NGEPL + ++ T+ +S +YQC N+HG +
Sbjct: 369 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL 428
Query: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-KKGRDILKE 122
+NA +SV+ V P R L R L++V ++C SP P W K G+ +
Sbjct: 429 LANAFVSVLDVPP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD 485
Query: 123 NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVT 182
+ E+G+L I + K D G YTC+ATN G A + L VKDPTR+ P
Sbjct: 486 GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAR 545
Query: 183 VGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKH 242
G ++ L C+V HD SL + +W + D R+ +D + L I + +
Sbjct: 546 RGTTVQLECRVKHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LTIFGVAERD 597
Query: 243 AGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMY 302
G Y C+ T +D+ A A L V G P P + + ++ + + +L+W PG N+SPIT Y
Sbjct: 598 QGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDY 657
Query: 303 VIQ-ARTPFSVG-WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRP 360
V+Q F G W S P ++ + V+ L+P+V Y+FR +A N +G PS P
Sbjct: 658 VVQFEEDQFQPGVWHDHSKYPGSVN-----SAVLRLSPYVNYQFRVIAINEVGSSHPSLP 712
Query: 361 SEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAF-RPYGKMIW 419
SE+ RT A PE P +V G G K+ + ITW + G Y+V + R + W
Sbjct: 713 SERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAW 772
Query: 420 -MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPA 478
+TV SRYV V + P+E++V N+ G+GP + + YS E+ P P
Sbjct: 773 NNVTVW----GSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPT 826
Query: 479 SIFARSLSATDIEVFWASPLEKN-RGRIQGYEVKYWRHEDKEEN------ARKIRTVGNQ 531
+ R +++T I + W +G+++ Y YWR +N ++ G++
Sbjct: 827 EVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDR 886
Query: 532 TSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIIL 591
++ L Y L + N G GP S T TT + PS P + + I L
Sbjct: 887 LRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINL 946
Query: 592 NWD 594
WD
Sbjct: 947 EWD 949
Score = 85.9 bits (211), Expect = 1e-16
Identities = 150/688 (21%), Positives = 252/688 (36%), Gaps = 86/688 (12%)
Query: 8 ECKANGRPKPTYKWLKNGEPLLTRDRIQIEQ--GTLNITIVNLSDAGMYQCLAENKHGVI 65
EC A+G P P W K G L + D+ + E L IT V+ D+G Y CLA NK G I
Sbjct: 278 ECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSI 336
Query: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWK-KGRDILKENE 124
+ V A + ++ G + + C+ +PKP W G +
Sbjct: 337 RHTISVRVKAAPYWLDE---PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP 393
Query: 125 RITISEDGNLRIINVTK-SDAGSYTCIATNHFGTASSTGNLVVKD-PTRVMVPPSSM-DV 181
G+ I T+ S Y C +N G + + V D P R++ P + + V
Sbjct: 394 NPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRV 453
Query: 182 TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK 241
+ L C S W NG + D H G L I+ I+ +
Sbjct: 454 ILYNRTRLDCPFF--GSPIPTLRWFKNGQGSNLDGGNYHVY------ENGSLEIKMIRKE 505
Query: 242 HAGKYVCMVQTSVDRLSAAADLIVRGPP---GPPEAVTIDEIT--DTTAQLSWRPGPDNH 296
G Y C+ + + L V+ P PE D++ TT QL R D
Sbjct: 506 DQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE----DQVARRGTTVQLECRVKHDPS 561
Query: 297 SPITMYVIQARTPFSVGWQ--------AVSTVPELIDGKTFTATVVGLNPWVEYEFRTVA 348
+T+ ++ P +G + + V E G L+ + + TV
Sbjct: 562 LKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV- 620
Query: 349 ANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYV 408
+G P RP + T+ A + + +TW +P + N YV
Sbjct: 621 -----LGRPDRPRDLELTDLA---------------ERSVRLTW--IPGDANNSPITDYV 658
Query: 409 VAFR--PYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEG-PFSPTTV 465
V F + +W + V R + P+ ++ +V N G P P+
Sbjct: 659 VQFEEDQFQPGVWHDHSKYPGSVNSAVLR---LSPYVNYQFRVIAINEVGSSHPSLPSER 715
Query: 466 VYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKY---WRHEDKEENA 522
++ P P + ++E+ W +P+ N G ++Y WR + E
Sbjct: 716 YRTSGAPPESNPGDVKGEGTRKNNMEITW-TPM--NATSAFGPNLRYIVKWRRRETREAW 772
Query: 523 RKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNI-I 581
+ G++ T + V Y + V+A N G GP +V + + P P + +
Sbjct: 773 NNVTVWGSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKV 830
Query: 582 WNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFD---- 637
+ + I L W++V + + +++ Y+ Y W S + ++ + S P D
Sbjct: 831 RVMNSTAISLQWNRVYSDTVQGQLREYRAYY-WRESSLLKNLWVSQKRQQASFPGDRLRG 889
Query: 638 --------EDYIIEIKPFSDGGDGSSSE 657
+Y +E+ + GDG SE
Sbjct: 890 VVSRLFPYSNYKLEMVVVNGRGDGPRSE 917
Score = 63.9 bits (154), Expect = 5e-10
Identities = 72/308 (23%), Positives = 119/308 (38%), Gaps = 51/308 (16%)
Query: 3 ENVFWECKANGRPKPTYKWLKNGE--PLLTRDRIQIEQGTLNITIVNLSDA------GMY 54
+N+ EC+A G P P++ W +N + R+ + + + + I S G Y
Sbjct: 51 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110
Query: 55 QCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKAS-PKPVYTW 113
QC A NK G SN ++ P + + L V +V+ G + ++C P P PV W
Sbjct: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV-VVQEGAPLTLQCNPPPGLPSPVIFW 169
Query: 114 -KKGRDILKENERITISEDGNLRIINVTKSDAGS-YTC-------------------IAT 152
+ + +++R++ +G+L NV D + Y+C + T
Sbjct: 170 MSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT 229
Query: 153 NHFGTASSTGNL--------VVKDPTRVMVP---PSSMDVTVGESIVLPCQVTHDHSLDI 201
NH SS N V + M P SS V G ++L C + + DI
Sbjct: 230 NHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 289
Query: 202 VFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAA 261
W G D D FE L I N+ + +G+Y C+ + +
Sbjct: 290 --AWYKKGG--DLPSDKAKFENFNKA-----LRITNVSEEDSGEYFCLASNKMGSIRHTI 340
Query: 262 DLIVRGPP 269
+ V+ P
Sbjct: 341 SVRVKAAP 348
Score = 53.9 bits (128), Expect = 5e-07
Identities = 47/182 (25%), Positives = 80/182 (43%), Gaps = 11/182 (6%)
Query: 90 LVKVGGEVVIECKPKASPKPVYTW-KKGRDILKENERITISEDGNLRIINVTKSDAGSYT 148
+V G ++++EC P P W KKG D+ + + + + LRI NV++ D+G Y
Sbjct: 268 MVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYF 326
Query: 149 CIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFN 208
C+A+N G+ T ++ VK + P ++ + GE L C+ + + W N
Sbjct: 327 CLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTV--QWMVN 384
Query: 209 GHLIDFDRDGDHFERVGGQDSAGDLMI-RNIQLKHAGKYVCMVQTSVDRLSAAADLIVRG 267
G + + ++ AGD +I R+ Q+ Y C L A A + V
Sbjct: 385 GEPLQSAPPNPN------REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLD 438
Query: 268 PP 269
P
Sbjct: 439 VP 440
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 259 bits (661), Expect = 8e-69
Identities = 183/623 (29%), Positives = 298/623 (47%), Gaps = 38/623 (6%)
Query: 8 ECKANGRPKPTYKWLKNGEPL--LTRD-RIQIEQGTLNITIVNLSDAGMYQCLAENKHGV 64
+C+ GRP+P W NG P+ L +D + +I++G L ++ V SD + QC A N+HG+
Sbjct: 348 DCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGL 407
Query: 65 IFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW--KKGRDILKE 122
+ +NA + V+ + P T + + G + CK +P P W + G +L++
Sbjct: 408 LLANAYIYVVQL-PAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQD 466
Query: 123 NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVT 182
ER +G L I ++ +D G Y C+A N + NL VKD T++ P S
Sbjct: 467 -ERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEK 525
Query: 183 VGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKH 242
G + CQ + D SL TW +G + D D + G+ L+I ++
Sbjct: 526 KGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGR-----LVIHSLDYSD 580
Query: 243 AGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEI---TDTTAQLSWRPGPDNHSPI 299
G Y C+ T +D + + A L+V G PGP + + ++ T + ++SW P D+++PI
Sbjct: 581 QGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPI 640
Query: 300 TMYVIQARTPFSVG--WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEP 357
Y I+ W ++ VP T+T + L+P+V Y FR A N G GEP
Sbjct: 641 EKYDIEFEDKEMAPEKWYSLGKVPG-----NQTSTTLKLSPYVHYTFRVTAINKYGPGEP 695
Query: 358 SRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYG-K 416
S SE T EA PE P +V G G + +VITW+ + N Y V +RP G +
Sbjct: 696 SPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTR 755
Query: 417 MIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKP 476
W +++ V N S F P+E+KV N++G+GP T+ YS E+ P
Sbjct: 756 GPWQEQIVSD---PFLVVSNTST--FVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAI 810
Query: 477 PASIFARSLSATDIEVFWAS-PLEKNRGRIQGYEVKYWRHEDKEENARK------IRTVG 529
P L+++ + V W L + +G ++GY V YWR + +++++ +
Sbjct: 811 PELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPA 870
Query: 530 NQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKI 589
N TS ++ L+ YHL V+A+N G+GP+S +T + P P + S++ +
Sbjct: 871 NTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS-EFTFSTPEGVPGHPEALHLECQSNTSL 929
Query: 590 ILNWDQVKALDNESEVKGYKVLY 612
+L W L + + GY + Y
Sbjct: 930 LLRWQ--PPLSHNGVLTGYVLSY 950
Score = 77.4 bits (189), Expect = 4e-14
Identities = 86/335 (25%), Positives = 148/335 (44%), Gaps = 65/335 (19%)
Query: 3 ENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQI------EQGTLNITIVNLSDA----G 52
+++ +C+A+G+P+ ++W ++G ++ + + G+ IT N + A G
Sbjct: 46 DDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQG 105
Query: 53 MYQCLAENKHGVIFSNAELSVIAVG-PDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVY 111
+Y+C A NK G S+ E+ ++A G P + + +K V V+ G VV+ C P S +P+
Sbjct: 106 IYRCFASNKLGTAMSH-EIRLMAEGAPKWPKETVKPVE-VEEGESVVLPCNPPPSAEPLR 163
Query: 112 TWKKGRDIL--KENERITISEDGNLRIINVTKSDAGS-YTCIATNHF-GT---------- 157
+ IL K++ER+T+ ++GNL NV SD S Y C A HF GT
Sbjct: 164 IYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHA--HFPGTRTIIQKEPID 221
Query: 158 --ASSTGNLVVKDPTRVMVPPSSMDVTV---GESIVLPCQVTHDHSLDIVFTWSFNGHLI 212
+T +++ + P R++ P +S V G+ +VL C F I
Sbjct: 222 LRVKATNSMIDRKP-RLLFPTNSSSHLVALQGQPLVLEC-----------IAEGFPTPTI 269
Query: 213 DFDRDGDHF--ERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP- 269
+ R +RV Q+ L + + + G+Y C+ + S+ A + V P
Sbjct: 270 KWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPY 329
Query: 270 ----------GPPEAVTIDEITDTTAQLSWRPGPD 294
GP E +D Q+ RP P+
Sbjct: 330 WLHKPQSHLYGPGETARLD------CQVQGRPQPE 358
Score = 47.0 bits (110), Expect = 6e-05
Identities = 30/116 (25%), Positives = 50/116 (43%), Gaps = 2/116 (1%)
Query: 94 GGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATN 153
G +V+EC + P P W + + + + + L+++ V + D G Y C+A N
Sbjct: 252 GQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAEN 311
Query: 154 HFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNG 209
G+A + V+ + P S GE+ L CQV ++ TW NG
Sbjct: 312 SLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEV--TWRING 365
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 259 bits (661), Expect = 8e-69
Identities = 183/623 (29%), Positives = 298/623 (47%), Gaps = 38/623 (6%)
Query: 8 ECKANGRPKPTYKWLKNGEPL--LTRD-RIQIEQGTLNITIVNLSDAGMYQCLAENKHGV 64
+C+ GRP+P W NG P+ L +D + +I++G L ++ V SD + QC A N+HG+
Sbjct: 353 DCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGL 412
Query: 65 IFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW--KKGRDILKE 122
+ +NA + V+ + P T + + G + CK +P P W + G +L++
Sbjct: 413 LLANAYIYVVQL-PAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQD 471
Query: 123 NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVT 182
ER +G L I ++ +D G Y C+A N + NL VKD T++ P S
Sbjct: 472 -ERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEK 530
Query: 183 VGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKH 242
G + CQ + D SL TW +G + D D + G+ L+I ++
Sbjct: 531 KGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGR-----LVIHSLDYSD 585
Query: 243 AGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEI---TDTTAQLSWRPGPDNHSPI 299
G Y C+ T +D + + A L+V G PGP + + ++ T + ++SW P D+++PI
Sbjct: 586 QGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPI 645
Query: 300 TMYVIQARTPFSVG--WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEP 357
Y I+ W ++ VP T+T + L+P+V Y FR A N G GEP
Sbjct: 646 EKYDIEFEDKEMAPEKWYSLGKVPG-----NQTSTTLKLSPYVHYTFRVTAINKYGPGEP 700
Query: 358 SRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYG-K 416
S SE T EA PE P +V G G + +VITW+ + N Y V +RP G +
Sbjct: 701 SPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTR 760
Query: 417 MIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKP 476
W +++ V N S F P+E+KV N++G+GP T+ YS E+ P
Sbjct: 761 GPWQEQIVSD---PFLVVSNTST--FVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAI 815
Query: 477 PASIFARSLSATDIEVFWAS-PLEKNRGRIQGYEVKYWRHEDKEENARK------IRTVG 529
P L+++ + V W L + +G ++GY V YWR + +++++ +
Sbjct: 816 PELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPA 875
Query: 530 NQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKI 589
N TS ++ L+ YHL V+A+N G+GP+S +T + P P + S++ +
Sbjct: 876 NTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS-EFTFSTPEGVPGHPEALHLECQSNTSL 934
Query: 590 ILNWDQVKALDNESEVKGYKVLY 612
+L W L + + GY + Y
Sbjct: 935 LLRWQ--PPLSHNGVLTGYVLSY 955
Score = 77.4 bits (189), Expect = 4e-14
Identities = 86/335 (25%), Positives = 148/335 (44%), Gaps = 65/335 (19%)
Query: 3 ENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQI------EQGTLNITIVNLSDA----G 52
+++ +C+A+G+P+ ++W ++G ++ + + G+ IT N + A G
Sbjct: 51 DDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQG 110
Query: 53 MYQCLAENKHGVIFSNAELSVIAVG-PDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVY 111
+Y+C A NK G S+ E+ ++A G P + + +K V V+ G VV+ C P S +P+
Sbjct: 111 IYRCFASNKLGTAMSH-EIRLMAEGAPKWPKETVKPVE-VEEGESVVLPCNPPPSAEPLR 168
Query: 112 TWKKGRDIL--KENERITISEDGNLRIINVTKSDAGS-YTCIATNHF-GT---------- 157
+ IL K++ER+T+ ++GNL NV SD S Y C A HF GT
Sbjct: 169 IYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHA--HFPGTRTIIQKEPID 226
Query: 158 --ASSTGNLVVKDPTRVMVPPSSMDVTV---GESIVLPCQVTHDHSLDIVFTWSFNGHLI 212
+T +++ + P R++ P +S V G+ +VL C F I
Sbjct: 227 LRVKATNSMIDRKP-RLLFPTNSSSHLVALQGQPLVLEC-----------IAEGFPTPTI 274
Query: 213 DFDRDGDHF--ERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP- 269
+ R +RV Q+ L + + + G+Y C+ + S+ A + V P
Sbjct: 275 KWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPY 334
Query: 270 ----------GPPEAVTIDEITDTTAQLSWRPGPD 294
GP E +D Q+ RP P+
Sbjct: 335 WLHKPQSHLYGPGETARLD------CQVQGRPQPE 363
Score = 47.0 bits (110), Expect = 6e-05
Identities = 30/116 (25%), Positives = 50/116 (43%), Gaps = 2/116 (1%)
Query: 94 GGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATN 153
G +V+EC + P P W + + + + + L+++ V + D G Y C+A N
Sbjct: 257 GQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAEN 316
Query: 154 HFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNG 209
G+A + V+ + P S GE+ L CQV ++ TW NG
Sbjct: 317 SLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEV--TWRING 370
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 259 bits (661), Expect = 8e-69
Identities = 183/623 (29%), Positives = 298/623 (47%), Gaps = 38/623 (6%)
Query: 8 ECKANGRPKPTYKWLKNGEPL--LTRD-RIQIEQGTLNITIVNLSDAGMYQCLAENKHGV 64
+C+ GRP+P W NG P+ L +D + +I++G L ++ V SD + QC A N+HG+
Sbjct: 353 DCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGL 412
Query: 65 IFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW--KKGRDILKE 122
+ +NA + V+ + P T + + G + CK +P P W + G +L++
Sbjct: 413 LLANAYIYVVQL-PAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQD 471
Query: 123 NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVT 182
ER +G L I ++ +D G Y C+A N + NL VKD T++ P S
Sbjct: 472 -ERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEK 530
Query: 183 VGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKH 242
G + CQ + D SL TW +G + D D + G+ L+I ++
Sbjct: 531 KGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGR-----LVIHSLDYSD 585
Query: 243 AGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEI---TDTTAQLSWRPGPDNHSPI 299
G Y C+ T +D + + A L+V G PGP + + ++ T + ++SW P D+++PI
Sbjct: 586 QGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPI 645
Query: 300 TMYVIQARTPFSVG--WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEP 357
Y I+ W ++ VP T+T + L+P+V Y FR A N G GEP
Sbjct: 646 EKYDIEFEDKEMAPEKWYSLGKVPG-----NQTSTTLKLSPYVHYTFRVTAINKYGPGEP 700
Query: 358 SRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYG-K 416
S SE T EA PE P +V G G + +VITW+ + N Y V +RP G +
Sbjct: 701 SPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTR 760
Query: 417 MIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKP 476
W +++ V N S F P+E+KV N++G+GP T+ YS E+ P
Sbjct: 761 GPWQEQIVSD---PFLVVSNTST--FVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAI 815
Query: 477 PASIFARSLSATDIEVFWAS-PLEKNRGRIQGYEVKYWRHEDKEENARK------IRTVG 529
P L+++ + V W L + +G ++GY V YWR + +++++ +
Sbjct: 816 PELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPA 875
Query: 530 NQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKI 589
N TS ++ L+ YHL V+A+N G+GP+S +T + P P + S++ +
Sbjct: 876 NTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS-EFTFSTPEGVPGHPEALHLECQSNTSL 934
Query: 590 ILNWDQVKALDNESEVKGYKVLY 612
+L W L + + GY + Y
Sbjct: 935 LLRWQ--PPLSHNGVLTGYVLSY 955
Score = 77.4 bits (189), Expect = 4e-14
Identities = 86/335 (25%), Positives = 148/335 (44%), Gaps = 65/335 (19%)
Query: 3 ENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQI------EQGTLNITIVNLSDA----G 52
+++ +C+A+G+P+ ++W ++G ++ + + G+ IT N + A G
Sbjct: 51 DDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQG 110
Query: 53 MYQCLAENKHGVIFSNAELSVIAVG-PDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVY 111
+Y+C A NK G S+ E+ ++A G P + + +K V V+ G VV+ C P S +P+
Sbjct: 111 IYRCFASNKLGTAMSH-EIRLMAEGAPKWPKETVKPVE-VEEGESVVLPCNPPPSAEPLR 168
Query: 112 TWKKGRDIL--KENERITISEDGNLRIINVTKSDAGS-YTCIATNHF-GT---------- 157
+ IL K++ER+T+ ++GNL NV SD S Y C A HF GT
Sbjct: 169 IYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHA--HFPGTRTIIQKEPID 226
Query: 158 --ASSTGNLVVKDPTRVMVPPSSMDVTV---GESIVLPCQVTHDHSLDIVFTWSFNGHLI 212
+T +++ + P R++ P +S V G+ +VL C F I
Sbjct: 227 LRVKATNSMIDRKP-RLLFPTNSSSHLVALQGQPLVLEC-----------IAEGFPTPTI 274
Query: 213 DFDRDGDHF--ERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP- 269
+ R +RV Q+ L + + + G+Y C+ + S+ A + V P
Sbjct: 275 KWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPY 334
Query: 270 ----------GPPEAVTIDEITDTTAQLSWRPGPD 294
GP E +D Q+ RP P+
Sbjct: 335 WLHKPQSHLYGPGETARLD------CQVQGRPQPE 363
Score = 47.0 bits (110), Expect = 6e-05
Identities = 30/116 (25%), Positives = 50/116 (43%), Gaps = 2/116 (1%)
Query: 94 GGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATN 153
G +V+EC + P P W + + + + + L+++ V + D G Y C+A N
Sbjct: 257 GQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAEN 316
Query: 154 HFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNG 209
G+A + V+ + P S GE+ L CQV ++ TW NG
Sbjct: 317 SLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEV--TWRING 370
>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
Length = 1189
Score = 256 bits (653), Expect = 7e-68
Identities = 187/618 (30%), Positives = 286/618 (46%), Gaps = 54/618 (8%)
Query: 9 CKANGRPKPTYKWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVI 65
C+ANG PKPT +W+ NGEPL + ++ T+ +S +YQC N+HG +
Sbjct: 369 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL 428
Query: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-KKGRDILKE 122
+NA +SV+ V P R L R L++V ++C SP P W K G+ +
Sbjct: 429 LANAFVSVLDVPP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD 485
Query: 123 NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVT 182
+ E+G+L I + K D G YTC+ATN G A + L VKDPTR+ P
Sbjct: 486 GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAR 545
Query: 183 VGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKH 242
G ++ L C+V HD SL + +W + D R+ +D + L I + +
Sbjct: 546 RGTTVQLECRVKHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LTIFGVAERD 597
Query: 243 AGKYVCMVQTSVDRLSAAADLIV---------------RGPPGPPEAVTIDEITDTTAQL 287
G Y C+ T +D+ A A L V +G P P + + ++ + + +L
Sbjct: 598 QGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRL 657
Query: 288 SWRPGPDNHSPITMYVIQ-ARTPFSVG-WQAVSTVPELIDGKTFTATVVGLNPWVEYEFR 345
+W PG N+SPIT YV+Q F G W S P ++ + V+ L+P+V Y+FR
Sbjct: 658 TWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN-----SAVLRLSPYVNYQFR 712
Query: 346 TVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGF 405
+A N +G PS PSE+ RT A PE P +V G G K+ + ITW + G
Sbjct: 713 VIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNL 772
Query: 406 GYVVAF-RPYGKMIW-MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPT 463
Y+V + R + W +TV SRYV V + P+E++V N+ G+GP +
Sbjct: 773 RYIVKWRRRETREAWNNVTVW----GSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPES 826
Query: 464 TVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKN-RGRIQGYEVKYWRHEDKEEN- 521
+ YS E+ P P + R +++T I + W +G+++ Y YWR +N
Sbjct: 827 VIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNL 886
Query: 522 -----ARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQP 576
++ G++ ++ L Y L + N G GP S T TT + PS P
Sbjct: 887 WVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAP 946
Query: 577 PGNIIWNSSDSKIILNWD 594
+ + I L WD
Sbjct: 947 RRFRVRQPNLETINLEWD 964
Score = 84.3 bits (207), Expect = 3e-16
Identities = 151/697 (21%), Positives = 254/697 (36%), Gaps = 89/697 (12%)
Query: 8 ECKANGRPKPTYKWLKNGEPLLTRDRIQIEQ--GTLNITIVNLSDAGMYQCLAENKHGVI 65
EC A+G P P W K G L + D+ + E L IT V+ D+G Y CLA NK G I
Sbjct: 278 ECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSI 336
Query: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWK-KGRDILKENE 124
+ V A + ++ G + + C+ +PKP W G +
Sbjct: 337 RHTISVRVKAAPYWLDE---PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP 393
Query: 125 RITISEDGNLRIINVTK-SDAGSYTCIATNHFGTASSTGNLVVKD-PTRVMVPPSSM-DV 181
G+ I T+ S Y C +N G + + V D P R++ P + + V
Sbjct: 394 NPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRV 453
Query: 182 TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK 241
+ L C S W NG + D H G L I+ I+ +
Sbjct: 454 ILYNRTRLDCPFF--GSPIPTLRWFKNGQGSNLDGGNYHVY------ENGSLEIKMIRKE 505
Query: 242 HAGKYVCMVQTSVDRLSAAADLIVRGPP---GPPEAVTIDEIT--DTTAQLSWRPGPDNH 296
G Y C+ + + L V+ P PE D++ TT QL R D
Sbjct: 506 DQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE----DQVARRGTTVQLECRVKHDPS 561
Query: 297 SPITMYVIQARTPFSVGWQ--------AVSTVPELIDGKTFTATVVGLNPWVEYEFRTVA 348
+T+ ++ P +G + + V E G L+ + + TV
Sbjct: 562 LKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 621
Query: 349 AN---------VIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEEL 399
A+ + G P RP + T+ A + + +TW +P +
Sbjct: 622 ADQATPTNRLAALPKGRPDRPRDLELTDLA---------------ERSVRLTW--IPGDA 664
Query: 400 QNGRGFGYVVAFR--PYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGE 457
N YVV F + +W + V R + P+ ++ +V N G
Sbjct: 665 NNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLR---LSPYVNYQFRVIAINEVGS 721
Query: 458 G-PFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKY---W 513
P P+ ++ P P + ++E+ W +P+ N G ++Y W
Sbjct: 722 SHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITW-TPM--NATSAFGPNLRYIVKW 778
Query: 514 RHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPP 573
R + E + G++ T + V Y + V+A N G GP +V + + P
Sbjct: 779 RRRETREAWNNVTVWGSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPESVIGYSGEDYP 836
Query: 574 SQPPGNI-IWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVEL 632
P + + + + I L W++V + + +++ Y+ Y W S + ++ +
Sbjct: 837 RAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYY-WRESSLLKNLWVSQKRQQA 895
Query: 633 SLPFD------------EDYIIEIKPFSDGGDGSSSE 657
S P D +Y +E+ + GDG SE
Sbjct: 896 SFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSE 932
Score = 63.9 bits (154), Expect = 5e-10
Identities = 72/308 (23%), Positives = 119/308 (38%), Gaps = 51/308 (16%)
Query: 3 ENVFWECKANGRPKPTYKWLKNGE--PLLTRDRIQIEQGTLNITIVNLSDA------GMY 54
+N+ EC+A G P P++ W +N + R+ + + + + I S G Y
Sbjct: 51 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110
Query: 55 QCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKAS-PKPVYTW 113
QC A NK G SN ++ P + + L V +V+ G + ++C P P PV W
Sbjct: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV-VVQEGAPLTLQCNPPPGLPSPVIFW 169
Query: 114 -KKGRDILKENERITISEDGNLRIINVTKSDAGS-YTC-------------------IAT 152
+ + +++R++ +G+L NV D + Y+C + T
Sbjct: 170 MSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT 229
Query: 153 NHFGTASSTGNL--------VVKDPTRVMVP---PSSMDVTVGESIVLPCQVTHDHSLDI 201
NH SS N V + M P SS V G ++L C + + DI
Sbjct: 230 NHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 289
Query: 202 VFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAA 261
W G D D FE L I N+ + +G+Y C+ + +
Sbjct: 290 --AWYKKGG--DLPSDKAKFENFNKA-----LRITNVSEEDSGEYFCLASNKMGSIRHTI 340
Query: 262 DLIVRGPP 269
+ V+ P
Sbjct: 341 SVRVKAAP 348
Score = 53.9 bits (128), Expect = 5e-07
Identities = 47/182 (25%), Positives = 80/182 (43%), Gaps = 11/182 (6%)
Query: 90 LVKVGGEVVIECKPKASPKPVYTW-KKGRDILKENERITISEDGNLRIINVTKSDAGSYT 148
+V G ++++EC P P W KKG D+ + + + + LRI NV++ D+G Y
Sbjct: 268 MVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYF 326
Query: 149 CIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFN 208
C+A+N G+ T ++ VK + P ++ + GE L C+ + + W N
Sbjct: 327 CLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTV--QWMVN 384
Query: 209 GHLIDFDRDGDHFERVGGQDSAGDLMI-RNIQLKHAGKYVCMVQTSVDRLSAAADLIVRG 267
G + + ++ AGD +I R+ Q+ Y C L A A + V
Sbjct: 385 GEPLQSAPPNPN------REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLD 438
Query: 268 PP 269
P
Sbjct: 439 VP 440
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 241 bits (614), Expect = 2e-63
Identities = 189/676 (27%), Positives = 307/676 (45%), Gaps = 37/676 (5%)
Query: 1 MEENVFWECKANGRPKPTYKWLKNGEPL----LTRDRIQIEQGTLNITIVNLSDAGMYQC 56
ME+ V C+A G P P+ W K+ + LTR R Q G L I+ + D GM+QC
Sbjct: 322 MEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFR-QRNDGGLQISGLVPDDTGMFQC 380
Query: 57 LAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKG 116
A N G + ++ L+V ++ P+ +R L + G VV+ C+ +P+P TW+KG
Sbjct: 381 FARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVID--GMSVVLACETSGAPRPAITWQKG 438
Query: 117 RDILKENE----RITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRV 172
IL R T E G+L I SDAG+YTC+ATN G ++ +LVV TR+
Sbjct: 439 ERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRI 498
Query: 173 MVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGD 232
PP V G + C VTHD + I + W +G + G D G
Sbjct: 499 TKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATL-----GTESHPRIRLDRNGS 553
Query: 233 LMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPE--AVTIDEITDTTAQLSWR 290
L I G Y C V ++ S +A L VR P PE T+ + L+W
Sbjct: 554 LHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWT 613
Query: 291 PGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAAN 350
D +SP+ Y+++ + + W + + +D K + TV GL P Y+FR A N
Sbjct: 614 KPFDGNSPLIRYILE-MSENNAPW---TVLLASVDPKATSVTVKGLVPARSYQFRLCAVN 669
Query: 351 VIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVA 410
+G G+ S+ +E+ E P P NV G + ++I W+ PE QNG GY++
Sbjct: 670 DVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIR 729
Query: 411 FRPYGKMI-WMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSA 469
+ G + + + AD + + E + ++ +E++V +N+ G G +S ++
Sbjct: 730 YCLAGLPVGYQFKNITDADVNNLLL--EDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTL 787
Query: 470 EEEPTKPPASIFARSLSATDIEVFWASPLEK-NRGRIQGYEVKYWRHEDKEENARKIRTV 528
+ PT PP ++ A + ++T I W +P + G QGY++ W E +EE
Sbjct: 788 QGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARP 847
Query: 529 GNQTSTK---ITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNS- 584
Q S ++ LK Y +V + + G GP S V T + P P G++ ++
Sbjct: 848 NFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPG-PVGHLSFSEI 906
Query: 585 SDSKIILNWDQVKALDNESEVKGYKVLY-RWNRQSSTSVIETNKTSVE---LSLPFDEDY 640
D+ + ++W + + + GY++ + +NR ++ ++E L Y
Sbjct: 907 LDTSLKVSWQEPG--EKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTY 964
Query: 641 IIEIKPFSDGGDGSSS 656
IE+ + G G S
Sbjct: 965 TIEVAAMTSKGQGQVS 980
Score = 141 bits (356), Expect = 2e-33
Identities = 106/381 (27%), Positives = 171/381 (44%), Gaps = 32/381 (8%)
Query: 259 AAADLIV----RGPPGPPEAVTI--DEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSV 312
AA L+V R P PP + +++ + LSW PG D SP+ Y IQ R S
Sbjct: 1386 AAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSG 1445
Query: 313 GWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPE 372
W S + + V L P+ Y+FR A N IG E S SE T +A P+
Sbjct: 1446 RWALHSAS---VSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPD 1502
Query: 373 VTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPY---GKMIWMLTVLASADA 429
P +S + + ++I W+ E+ NG G+ + +R G + L + + A
Sbjct: 1503 EAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGA 1562
Query: 430 ------SRYVFRN-----------ESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEE 472
S Y RN ++++ +E+++ V+N GEGP SP V+ E
Sbjct: 1563 TWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAV 1622
Query: 473 PTKPPASIFARSLSATDIEVFW-ASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQ 531
PT P ++ +AT ++V W PL+ G IQGY++ +W + R +
Sbjct: 1623 PTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAE 1682
Query: 532 TSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIIL 591
S K+ NL G Y ++V A+N+AG GP S T++ PS P + + + +
Sbjct: 1683 NSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNV 1742
Query: 592 NWDQVKALDNESEVKGYKVLY 612
+W+ + + E GY+++Y
Sbjct: 1743 SWEAPQFPNGILE--GYRLVY 1761
Score = 130 bits (326), Expect = 5e-30
Identities = 108/384 (28%), Positives = 179/384 (46%), Gaps = 28/384 (7%)
Query: 269 PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVG----WQAVSTVPELI 324
PGPP + I I + L +RPG D + I+ ++++A+ VG W + +
Sbjct: 993 PGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGV-VGEGEEWLLIHQLSNEP 1051
Query: 325 DGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGS 384
D ++ V LNP+ Y FR N++G PS+PS K +T +A P++ PANVS S
Sbjct: 1052 DARSME--VPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTAS 1109
Query: 385 KSELVITWETVPEELQNG--RGFGYVVAFR---PYGKMIWMLTVLASADASRYVFRNESV 439
++ L + W +PE NG GY + + +GK + + D + E +
Sbjct: 1110 ETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVV----QDRVERDYTIEDL 1165
Query: 440 HPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLE 499
++ + V+V FN G GP+S T V + E P+ P ++ A + +++ + V W+ E
Sbjct: 1166 EEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPE 1225
Query: 500 KNR-GRIQGYEVKYWRHEDKEENARKIRTVGNQT-STKITNLKGSVLYHLAVKAYNSAGT 557
+R G + GY+V Y + +D + R GN + S ++T L VLY + V A+ G
Sbjct: 1226 ADRNGLVLGYKVMY-KEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGD 1284
Query: 558 G-PSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNR 616
G PS + T P P G + + + L W Q A N + Y++ +R N
Sbjct: 1285 GSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIW-QPPAAPN-GIILAYQITHRLNT 1342
Query: 617 QSSTSVIETNKTSVELSLPFDEDY 640
++ N +VE+ P Y
Sbjct: 1343 TTA------NTATVEVLAPSARQY 1360
Score = 101 bits (252), Expect = 2e-21
Identities = 98/404 (24%), Positives = 163/404 (40%), Gaps = 22/404 (5%)
Query: 268 PPGPPEAVTIDEITDTTAQLSWRPGPD---NHSPITM-YVIQARTPFSVGWQAVSTVPEL 323
P P V++ ++T+ L W P P+ N +P ++ Y I+ G V +
Sbjct: 1096 PDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDR 1155
Query: 324 IDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGG 383
++ T+ L W EY + A N IG G P + RT E++P P NVS
Sbjct: 1156 VERDY---TIEDLEEWTEYRVQVQAFNAIGSG-PWSQTVVGRTRESVPSSGPTNVSALAT 1211
Query: 384 SKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFS 443
+ S +++ W VPE +NG GY V ++ L ++SR + + +
Sbjct: 1212 TSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSA-QLTGLGKYV 1270
Query: 444 PFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRG 503
+EV+V F G+G S ++ ++ PP I + T + + W P N G
Sbjct: 1271 LYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPN-G 1329
Query: 504 RIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSAT 563
I Y++ + + A + T LK +Y + A G G ++
Sbjct: 1330 IILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEA 1389
Query: 564 VNVTTRKPPPSQPPGNIIWNSSDSK---IILNWDQVKALDNESEVKGYKVLY------RW 614
+ VTT K QPP + D + ++L+W+ D S V+ Y + RW
Sbjct: 1390 LVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE--PGSDGLSPVRYYTIQTRELPSGRW 1447
Query: 615 NRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQ 658
S++ + V+ PF Y +K +D GD SE+
Sbjct: 1448 ALHSASVSHNASSFIVDRLKPF-TSYKFRVKATNDIGDSEFSEE 1490
Score = 63.2 bits (152), Expect = 8e-10
Identities = 37/106 (34%), Positives = 51/106 (48%), Gaps = 4/106 (3%)
Query: 267 GPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQA-VSTVPELID 325
G PGPP I + A + W G PIT YVI+AR W + +P+ +
Sbjct: 1823 GAPGPPGVPIIVRYSSAIA-IHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVS 1881
Query: 326 GKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALP 371
TF+ + L P V Y+FR +A N G G PS PS+ ++A P
Sbjct: 1882 SYTFSMDI--LKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1925
Score = 61.2 bits (147), Expect = 3e-09
Identities = 76/307 (24%), Positives = 117/307 (38%), Gaps = 38/307 (12%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSN 68
C A G +KWL N L + +E + IT ++ + AG Y+C+ N+ G +
Sbjct: 48 CMAEGSWPLEFKWLHNNRELT---KFSLEYRYM-ITSLDRTHAGFYRCIVRNRMGALLQR 103
Query: 69 AELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKAS-PKPVYTWKKGRDILKENERIT 127
+A F ++ V G VI AS P+P TW + + + RI
Sbjct: 104 QTEVQVAYMGSFEEG--EKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIA 161
Query: 128 ISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVV---------KDP--TRVMVPP 176
I+ + L I++ DAG Y A N + T + DP +++PP
Sbjct: 162 ITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPP 221
Query: 177 SSMDVTVGES-IVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMI 235
+ V G S + L C + + W +G L+ DH R L I
Sbjct: 222 KNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLS-GGISDHNRR---------LTI 271
Query: 236 RNIQLKHAGKYVC---MVQTSVDRLSAAADLIVRGPP----GPPEAVT--IDEITDTTAQ 286
N AG Y C + +SV + A L V PP P +T ++++ D Q
Sbjct: 272 PNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQ 331
Query: 287 LSWRPGP 293
P P
Sbjct: 332 AKGVPPP 338
Score = 61.2 bits (147), Expect = 3e-09
Identities = 90/450 (20%), Positives = 168/450 (37%), Gaps = 39/450 (8%)
Query: 268 PPGPPEAVTIDEITDTTAQLSWR-PGPDNHSPITM-YVIQARTPFSVGWQAVSTVPELID 325
P PP V + TT + +W P P + I Y + A P + T
Sbjct: 791 PTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQ 850
Query: 326 GKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSK 385
V GL + EY + G G S P + RT E +P ++S
Sbjct: 851 DSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTP-QLVRTHEDVPGPV-GHLSFSEILD 908
Query: 386 SELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPF 445
+ L ++W+ E+ NG GY +++ Y + +T Y R + + +
Sbjct: 909 TSLKVSWQEPGEK--NGILTGYRISWEEYNRTNTRVTHYLPNVTLEY--RVTGLTALTTY 964
Query: 446 EVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRI 505
++V +KG+G S +T+ E PP ++ ++ + L+ G
Sbjct: 965 TIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSV------TLQFRPGYD 1018
Query: 506 QGYEVKYWRHE------DKEENARKIRTVGNQ---TSTKITNLKGSVLYHLAVKAYNSAG 556
+ W E + E I + N+ S ++ +L Y ++ N G
Sbjct: 1019 GKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVG 1078
Query: 557 TG-PSSATVNVTTRKPPPSQPPGNI-IWNSSDSKIILNWDQVKALD--NESEVKGYKVLY 612
T PS + + T + PP P N+ + +S++ + L W + ++ E GYK+ Y
Sbjct: 1079 TSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKY 1138
Query: 613 RWNRQSSTSVIETNKTSVELSLPFDE-----DYIIEIKPFSDGGDGSSSEQIRIPKISNA 667
+ ++ + VE ++ +Y ++++ F+ G G S+ +
Sbjct: 1139 SRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTV-------V 1191
Query: 668 YARGSGASTSNACTLSAISTIMISLTARSS 697
+S +SA++T S+ R S
Sbjct: 1192 GRTRESVPSSGPTNVSALATTSSSMLVRWS 1221
>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
Length = 1240
Score = 238 bits (606), Expect = 2e-62
Identities = 183/604 (30%), Positives = 275/604 (45%), Gaps = 56/604 (9%)
Query: 9 CKANGRPKPTYKWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVI 65
C+ANG PKPT +W+ NGEPL + ++ T+ +S +YQC N+HG +
Sbjct: 358 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL 417
Query: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-KKGRDILKE 122
+NA +SV+ V P R L R L++V ++C SP P W K G+ +
Sbjct: 418 LANAFVSVLDVPP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD 474
Query: 123 NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVT 182
+ E+G+L I + K D G YTC+ATN G A + L VKDPTR+ P
Sbjct: 475 GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAR 534
Query: 183 VGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKH 242
G ++ L C+V HD SL + +W + D R+ +D + L I + +
Sbjct: 535 RGTTVQLECRVKHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LTIFGVAERD 586
Query: 243 AGKYVCMVQTSVDRLSAAADLIV---------------RGPPGPPEAVTIDEITDTTAQL 287
G Y C+ T +D+ A A L V +G P P + + ++ + + +L
Sbjct: 587 QGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRL 646
Query: 288 SWRPGPDNHSPITMYVIQ-ARTPFSVG-WQAVSTVPELIDGKTFTATVVGLNPWVEYEFR 345
+W PG N+SPIT YV+Q F G W S P ++ + V+ L+P+V Y+FR
Sbjct: 647 TWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN-----SAVLRLSPYVNYQFR 701
Query: 346 TVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGF 405
+A N +G PS PSE+ RT A PE P +V G G K+ + ITW + G
Sbjct: 702 VIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNL 761
Query: 406 GYVVAF-RPYGKMIW-MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPT 463
Y+V + R + W +TV SRYV V + P+E++V N+ G+GP +
Sbjct: 762 RYIVKWRRRETREAWNNVTVW----GSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPES 815
Query: 464 TVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENAR 523
+ YS E+ P+ P R + I + W P E G + GY +KY + +
Sbjct: 816 VIGYSGEDLPS-APRRFRVRQPNLETINLEWDHP-EHPNGIMIGYTLKYVAFNGTKVGKQ 873
Query: 524 KIRTVG-NQTSTKITNLKGSVLYHLAVKAYNSAGTG-----PSSATVN-VTTRKPPPSQP 576
+ NQT + Y + A G+G S A N T PP+ P
Sbjct: 874 IVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAPPTLP 933
Query: 577 PGNI 580
P +
Sbjct: 934 PTTV 937
Score = 75.1 bits (183), Expect = 2e-13
Identities = 139/621 (22%), Positives = 222/621 (35%), Gaps = 75/621 (12%)
Query: 8 ECKANGRPKPTYKWLKNGEPLLTRDRIQIEQ--GTLNITIVNLSDAGMYQCLAENKHGVI 65
EC A+G P P W K G L + D+ + E L IT V+ D+G Y CLA NK G I
Sbjct: 267 ECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSI 325
Query: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWK-KGRDILKENE 124
+ V A + ++ G + + C+ +PKP W G +
Sbjct: 326 RHTISVRVKAAPYWLDEP---KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP 382
Query: 125 RITISEDGNLRIINVTK-SDAGSYTCIATNHFGTASSTGNLVVKD-PTRVMVPPSSM-DV 181
G+ I T+ S Y C +N G + + V D P R++ P + + V
Sbjct: 383 NPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRV 442
Query: 182 TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK 241
+ L C S W NG + D H G L I+ I+ +
Sbjct: 443 ILYNRTRLDCPFFG--SPIPTLRWFKNGQGSNLDGGNYHVYE------NGSLEIKMIRKE 494
Query: 242 HAGKYVCMVQTSVDRLSAAADLIVRGPPG---PPEAVTIDEIT--DTTAQLSWRPGPDNH 296
G Y C+ + + L V+ P PE D++ TT QL R D
Sbjct: 495 DQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE----DQVARRGTTVQLECRVKHDPS 550
Query: 297 SPITMYVIQARTPFSVGWQ--------AVSTVPELIDGKTFTATVVGLNPWVEYEFRTVA 348
+T+ ++ P +G + + V E G L+ + + TV
Sbjct: 551 LKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610
Query: 349 AN---------VIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEEL 399
A+ + G P RP + T+ A V +TW +P +
Sbjct: 611 ADQATPTNRLAALPKGRPDRPRDLELTDLAERSVR---------------LTW--IPGDA 653
Query: 400 QNGRGFGYVVAFRP--YGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGE 457
N YVV F + +W + V R + P+ ++ +V N G
Sbjct: 654 NNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLR---LSPYVNYQFRVIAINEVGS 710
Query: 458 G-PFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKY---W 513
P P+ ++ P P + ++E+ W +P+ N G ++Y W
Sbjct: 711 SHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITW-TPM--NATSAFGPNLRYIVKW 767
Query: 514 RHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPP 573
R + E + G++ T + V Y + V+A N G GP +V + + P
Sbjct: 768 RRRETREAWNNVTVWGSRYVVGQTPVY--VPYEIRVQAENDFGKGPEPESVIGYSGEDLP 825
Query: 574 SQPPGNIIWNSSDSKIILNWD 594
S P + + I L WD
Sbjct: 826 SAPRRFRVRQPNLETINLEWD 846
Score = 69.3 bits (168), Expect = 1e-11
Identities = 70/296 (23%), Positives = 117/296 (39%), Gaps = 44/296 (14%)
Query: 3 ENVFWECKANGRPKPTYKWLKNGE--PLLTRDRIQIEQGTLNITIVNLSDA------GMY 54
+N+ EC+A G P P++ W +N + R+ + + + + I S G Y
Sbjct: 57 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 116
Query: 55 QCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKAS-PKPVYTW 113
QC A NK G SN ++ P + + L V +V+ G + ++C P P PV W
Sbjct: 117 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV-VVQEGAPLTLQCNPPPGLPSPVIFW 175
Query: 114 -KKGRDILKENERITISEDGNLRIINVTKSDAGS-YTCIATNHF---------------- 155
+ + +++R++ +G+L NV D + Y+C A HF
Sbjct: 176 MSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT 235
Query: 156 --GTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLID 213
G A T + + T SS V G ++L C + + DI W G D
Sbjct: 236 TRGVAERTPSFMYPQGT-----ASSQMVLRGMDLLLECIASGVPTPDI--AWYKKGG--D 286
Query: 214 FDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP 269
D FE L I N+ + +G+Y C+ + + + V+ P
Sbjct: 287 LPSDKAKFENFNKA-----LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 337
Score = 55.8 bits (133), Expect = 1e-07
Identities = 69/272 (25%), Positives = 112/272 (41%), Gaps = 24/272 (8%)
Query: 13 GRPKPTYKWLKNGEPLLTRDR--IQIEQGTLNITIVNLSDAGM-YQCLAENK--HGVIFS 67
G P P W+ + +T+D+ Q G L + V L D Y C A H +
Sbjct: 167 GLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK 226
Query: 68 NA-ELSVIAVGPDFSRT---LLKRVT----LVKVGGEVVIECKPKASPKPVYTW-KKGRD 118
N L V+ RT + + T +V G ++++EC P P W KKG D
Sbjct: 227 NPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGD 286
Query: 119 ILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSS 178
+ + + + + LRI NV++ D+G Y C+A+N G+ T ++ VK + P +
Sbjct: 287 LPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKN 345
Query: 179 MDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMI-RN 237
+ + GE L C+ + + W NG + + ++ AGD +I R+
Sbjct: 346 LILAPGEDGRLVCRANGNPKPTV--QWMVNGEPLQSAPPNPN------REVAGDTIIFRD 397
Query: 238 IQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP 269
Q+ Y C L A A + V P
Sbjct: 398 TQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 208 bits (529), Expect = 2e-53
Identities = 170/652 (26%), Positives = 284/652 (43%), Gaps = 37/652 (5%)
Query: 1 MEENVFWECKANGRPKPTYKWLKNGEPL--LTRDRIQI-EQGTLNITIVNLSDAGMYQCL 57
+EE V C+A G P PT +W K+ + L R ++ G L I + D+G++QC
Sbjct: 400 VEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCF 459
Query: 58 AENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGR 117
A N+ G I ++ L V + P F++ + T V G ++ C+ +PKP TWK+
Sbjct: 460 ASNEGGEIQTHTYLDVTNIAPVFTQRPVD--TTVTDGMTAILRCEVSGAPKPAITWKREN 517
Query: 118 DILKENE----RITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVM 173
IL R + E G L+I V DAG+YTC A N G+ +++ L V + T ++
Sbjct: 518 HILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIV 577
Query: 174 VPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDL 233
PP V G + L C THD + + + W + + R+ + G L
Sbjct: 578 HPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVAL----TPSSTSRI-VVEKDGSL 632
Query: 234 MIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTT--AQLSWRP 291
+I G Y C + + S A L V P P+ + + + + LSW
Sbjct: 633 LISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVR 692
Query: 292 GPDNHSPITMYVIQA---RTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVA 348
D +SPI Y+++ +P+ V V PE+ TV GL P Y+FR A
Sbjct: 693 PFDGNSPILYYIVELSENNSPWKVHLSNVG--PEMTG-----VTVSGLTPARTYQFRVCA 745
Query: 349 ANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYV 408
N +G G+ S + + E P P N+ G + +++ W+ PE NG GY+
Sbjct: 746 VNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYI 805
Query: 409 VAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYS 468
+ +R G ++ Y + + ++ +E++V +N G G FS Y+
Sbjct: 806 LRYRLAGLPGEYQQRNITSPEVNYCLVTDLI-IWTQYEIQVAAYNGAGLGVFSRAVTEYT 864
Query: 469 AEEEPTKPPASIFARSLSATDIEVFWASPLEK-NRGRIQGYEVKYWRHEDKEENARKIRT 527
+ PT PP ++ ++++T I+ W P ++ G QGY++ W + E A + T
Sbjct: 865 LQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPE--AVTVVT 922
Query: 528 VG----NQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWN 583
+ ITNLK Y +V + + G GP S V T++ P
Sbjct: 923 IAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTE 982
Query: 584 SSDSKIILNWDQVKALDNESEVKGYKVLYR-WNRQSSTSVIETNKTSVELSL 634
D+ + ++W + L+ + GY++ + + R S N T+ E +
Sbjct: 983 ILDTSLKVSWQE--PLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKI 1032
Score = 135 bits (339), Expect = 2e-31
Identities = 158/630 (25%), Positives = 251/630 (39%), Gaps = 85/630 (13%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTRDRIQI------EQGTLNITIVNLSDAGMYQCLAENKH 62
C+ +G PKP W K +L ++I E G L I V + DAG Y C A N
Sbjct: 501 CEVSGAPKPAITW-KRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTE 559
Query: 63 GVIFSNAELSV----IAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV--YTWKKG 116
G + ++A L+V V P ++K T + C P+ Y WKK
Sbjct: 560 GSLNASATLTVWNRTSIVHPPEDHVVIKGTT-------ATLHCGATHDPRVSLRYVWKKD 612
Query: 117 RDIL--KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD----PT 170
L RI + +DG+L I D G Y+C + G S L V + P
Sbjct: 613 NVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQ 672
Query: 171 RVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNG------HLIDFDRDGD----H 220
++V P+S +H H++ + + F+G ++++ + H
Sbjct: 673 NLLVSPNS---------------SHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVH 717
Query: 221 FERVG----GQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAAD-----LIVRGPPGP 271
VG G +G R Q + VC V V R +A+ L P P
Sbjct: 718 LSNVGPEMTGVTVSGLTPARTYQFR-----VCAVN-EVGRGQYSAETSRLMLPEEPPSAP 771
Query: 272 PEAVTIDEITDTTAQLSWRPGPD--NHSPITMYVIQARTPFSVG--WQAVSTVPELIDGK 327
P+ + T+ + + W+P P+ ++ + Y+++ R G Q T PE+
Sbjct: 772 PKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVN--- 828
Query: 328 TFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSE 387
V L W +YE + A N G+G SR + T + +P P NV + +
Sbjct: 829 --YCLVTDLIIWTQYEIQVAAYNGAGLGVFSR-AVTEYTLQGVPTAPPQNVQTEAVNSTT 885
Query: 388 LVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNE--SVHPFSPF 445
+ W P++ NG GY + P +TV+ A V ++ F+ +
Sbjct: 886 IQFLWNPPPQQFINGINQGYKLLAWP-ADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAY 944
Query: 446 EVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRI 505
V F G+GP S +V++ E++P F L T ++V W PLEKN G I
Sbjct: 945 FTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILD-TSLKVSWQEPLEKN-GII 1002
Query: 506 QGYEVKYWRHEDKEENARKIRTVGNQTST-KITNLKGSVLYHLAVKAYNSAGTG-PSSAT 563
GY++ W + ++ R T+ + T KI L Y + V A + GTG +S+T
Sbjct: 1003 TGYQIS-WEVYGRNDS-RLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSST 1060
Query: 564 VNVTTRKPPPSQPPGNIIWNSSDSKIILNW 593
++ P P +I N S L +
Sbjct: 1061 ISSGVPPDLPGAPSNLVISNISPRSATLQF 1090
Score = 122 bits (305), Expect = 1e-27
Identities = 95/371 (25%), Positives = 157/371 (42%), Gaps = 29/371 (7%)
Query: 266 RGPPGPPEAVTID--EITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPEL 323
R P PP + + E+T + +L W PG D SPI + +Q R WQ S+
Sbjct: 1474 RERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSS--- 1530
Query: 324 IDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGG 383
I + V L P+ Y+ R A N IG + S +E T + +P P +VS
Sbjct: 1531 ISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH 1590
Query: 384 SKSELVITWETVPEELQNGRGFGYVVAFRPYG------------KMIWMLTVLASADASR 431
+ S ++I W+ +E NG GY + +R K L +A +S
Sbjct: 1591 TTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSF 1650
Query: 432 YVFRNES---------VHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFA 482
+ S + + +EV + +N GE P S V+ E P P ++
Sbjct: 1651 KTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQV 1710
Query: 483 RSLSATDIEVFW-ASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKG 541
L+A+ +EV W P E G IQGY++ YW + + E + + ++ NL
Sbjct: 1711 TPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTS 1770
Query: 542 SVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDN 601
Y +++ A+N+AG GP S T + P P + + + ++W + A +
Sbjct: 1771 HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAAN- 1829
Query: 602 ESEVKGYKVLY 612
++GY+V+Y
Sbjct: 1830 -GILQGYRVVY 1839
Score = 114 bits (285), Expect = 3e-25
Identities = 104/434 (23%), Positives = 175/434 (40%), Gaps = 27/434 (6%)
Query: 268 PPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGK 327
P P +VT+ ++T+ +L W P PD+ + R + S V +++ +
Sbjct: 1173 PDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDR 1232
Query: 328 TFTA-TVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKS 386
T+ L W+EYE + A N +G G P + RT E++P P NVS S +
Sbjct: 1233 LEREFTIEELEEWMEYELQMQAFNAVGAG-PWSEVVRGRTRESVPSAAPENVSAEAVSST 1291
Query: 387 ELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNES-------V 439
++++TW +VPE+ QNG GY + FR L S V N + +
Sbjct: 1292 QILLTWTSVPEQDQNGLILGYKILFRAKD--------LDPEPRSHIVRGNHTQSALLAGL 1343
Query: 440 HPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLE 499
F +E++V F G G S ++ +++ PP + + T + + W P E
Sbjct: 1344 RKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEE 1403
Query: 500 KNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTG- 558
N G I GY++ Y + T+L Y + A G G
Sbjct: 1404 PN-GIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGE 1462
Query: 559 PSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYR----- 613
P ATV T ++ P+ P ++ + + L V D S ++ + + R
Sbjct: 1463 PLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRG 1522
Query: 614 -WNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGS-SSEQIRIPKISNAYARG 671
W SS+ E V+ PF Y + +K +D GD SSE + + +
Sbjct: 1523 EWQTYSSSISHEATACVVDRLRPF-TSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEP 1581
Query: 672 SGASTSNACTLSAI 685
G+ ++ T S++
Sbjct: 1582 PGSVSATPHTTSSV 1595
Score = 113 bits (283), Expect = 5e-25
Identities = 91/358 (25%), Positives = 161/358 (44%), Gaps = 24/358 (6%)
Query: 269 PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQA--VSTVPELIDG 326
PG P + I I+ +A L +RPG D + I+ ++++ + ++G + V+ E +
Sbjct: 1070 PGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVG-AIGDEEEWVTLYEEENEP 1128
Query: 327 KTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKS 386
+ L P+ Y FR N++G S S +T +A P+V P +V+ S++
Sbjct: 1129 DAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASET 1188
Query: 387 ELVITWETVPEELQNG--RGFGYVVAFRPYGKMIWMLTVLASA------DASRYVFRNES 438
L + W +P+ NG GY + + W + +SA D F E
Sbjct: 1189 SLRLRWVPLPDSQYNGNPESVGYRIKY-------WRSDLQSSAVAQVVSDRLEREFTIEE 1241
Query: 439 VHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWAS-P 497
+ + +E+++ FN G GP+S + E P+ P ++ A ++S+T I + W S P
Sbjct: 1242 LEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVP 1301
Query: 498 LEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQT-STKITNLKGSVLYHLAVKAYNSAG 556
+ G I GY++ + R +D + R GN T S + L+ VLY L V A+ G
Sbjct: 1302 EQDQNGLILGYKILF-RAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIG 1360
Query: 557 TG-PSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYR 613
G PS+ + T+ P P + + + + W + + + GY++ YR
Sbjct: 1361 NGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPE--EPNGIILGYQIAYR 1416
Score = 102 bits (254), Expect = 1e-21
Identities = 112/463 (24%), Positives = 188/463 (40%), Gaps = 59/463 (12%)
Query: 269 PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKT 328
PGPP + E+ T+ ++ W+P + + I Y I R S +TV +
Sbjct: 1378 PGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP-HTFTTVEVGATVRQ 1436
Query: 329 FTATVVGLNPWVEYEFRTVAANVIGIGEPSRPS---EKRRTEEALPE---VTPANVSGGG 382
FTAT L P Y FR A G GEP + ++R A P V A V+
Sbjct: 1437 FTAT--DLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTA-- 1492
Query: 383 GSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPF 442
L + W + R F V P G+ W T +S + + PF
Sbjct: 1493 ---RSLRLQWVPGSDGASPIRYFTMQVRELPRGE--WQ-TYSSSISHEATACVVDRLRPF 1546
Query: 443 SPFEVKVGVFNNKGEGPFSPTT-VVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKN 501
+ +++++ N+ G+ FS T V + ++ P +PP S+ A + + + + W P +++
Sbjct: 1547 TSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDES 1606
Query: 502 -RGRIQGYEVKYWRHEDKEENARKIRTVGN----------------------QTSTKITN 538
G +QGY + Y E + + + +T+ N T ++T+
Sbjct: 1607 LNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTH 1666
Query: 539 LKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNI-IWNSSDSKIILNWDQVK 597
LK Y + + AYN G P+SA V V + P+ P N+ + + S++ + WD
Sbjct: 1667 LKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPP 1726
Query: 598 ALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVEL---------SLPFDEDYIIEIKPFS 648
++GYK+ Y W S ET K V +L Y++ I F+
Sbjct: 1727 PESQNGNIQGYKIYY-WEADSQN---ETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFN 1782
Query: 649 DGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMIS 691
GDG S+ P+ + GA + A + +T+ +S
Sbjct: 1783 AAGDGPKSD----PQQGRTHQAAPGAPSFLAFSEITSTTLNVS 1821
Score = 72.0 bits (175), Expect = 2e-12
Identities = 80/297 (26%), Positives = 116/297 (39%), Gaps = 41/297 (13%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSN 68
C A G +KW+++ L T + I + DAG Y+C+ N+ G +
Sbjct: 126 CLAEGSWPLEFKWMRDDSELTTYS----SEYKYIIPSLQKLDAGFYRCVVRNRMGALLQR 181
Query: 69 AELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKAS-PKPVYTW-KKGRDILKENERI 126
+A F T ++ V G ++ P S P+P TW ++G I+ N RI
Sbjct: 182 KSEVQVAYMGSFMDTDQRKT--VSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSN-RI 238
Query: 127 TISEDGNLRIINVTKSDAGSYTCIATN------------HFGTASSTGNLVVKDPTRVMV 174
I+ + L I+ T SDAG+Y A N H A G PT ++V
Sbjct: 239 AITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPT-IVV 297
Query: 175 PPSSMDVTVGES-IVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAG-D 232
PP + V G S L C + D+ TW NG I G S G
Sbjct: 298 PPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRI-----------TSGLHSFGRR 346
Query: 233 LMIRNIQLKHAGKYVC---MVQTSVDRLSAAADLIVRGPP---GPPEAVTIDEITDT 283
L I N G YVC + ++ + A A L + PP PE+ E+ +T
Sbjct: 347 LTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEET 403
Score = 71.6 bits (174), Expect = 2e-12
Identities = 87/369 (23%), Positives = 142/369 (38%), Gaps = 63/369 (17%)
Query: 268 PPGPPEAVTIDEITDTTAQLSWRPGPDN-----------------------------HSP 298
P PP +V+ T ++ + W+P D +P
Sbjct: 1578 PGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNP 1637
Query: 299 ITMYV-IQARTPF-SVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGE 356
I ++ + A++ F +V + ST+ EL L + YE A N+IG
Sbjct: 1638 IALHAELTAQSSFKTVNSSSTSTMCEL----------THLKKYRRYEVIMTAYNIIGESP 1687
Query: 357 PSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGK 416
S P E EA P + P NV + S+L +TW+ P E QNG GY + +
Sbjct: 1688 ASAPVEV-FVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYY----- 1741
Query: 417 MIWMLTVLASADASRYVF------RNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAE 470
W + + +F R +++ + + V + FN G+GP S + +
Sbjct: 1742 --WEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQ 1799
Query: 471 EEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTV-- 528
P P F+ +++T + V W P N G +QGY V Y + K+ TV
Sbjct: 1800 AAPGAPSFLAFS-EITSTTLNVSWGEPAAAN-GILQGYRVVY-EPLAPVQGVSKVVTVEV 1856
Query: 529 -GN-QTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSD 586
GN Q K+ +L V Y V+A A + + P P +++ S
Sbjct: 1857 RGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGS-PRDVLVTKSA 1915
Query: 587 SKIILNWDQ 595
S++ L W +
Sbjct: 1916 SELTLQWTE 1924
Score = 54.7 bits (130), Expect = 3e-07
Identities = 35/96 (36%), Positives = 46/96 (47%), Gaps = 4/96 (4%)
Query: 267 GPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQA-VSTVPELID 325
G PG P V + + + + L W G +P T YVI+AR W V +P
Sbjct: 1901 GSPGSPRDVLVTK-SASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPR--S 1957
Query: 326 GKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPS 361
++T ++ L V YEFR VA N G GEPS PS
Sbjct: 1958 ATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPS 1993
Score = 42.7 bits (99), Expect = 0.001
Identities = 57/215 (26%), Positives = 77/215 (35%), Gaps = 23/215 (10%)
Query: 269 PGPPEAVTIDEITDTTAQLSW-RPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGK 327
PG P + EIT TT +SW P N V+ G V TV E+
Sbjct: 1802 PGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTV-EVRGNW 1860
Query: 328 TFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSE 387
V L V Y FR V A I G E +T G GS +
Sbjct: 1861 QRWLKVRDLTKGVTYFFR-VQARTITYG-----------PELQANITAGPAEGSPGSPRD 1908
Query: 388 LVITWETVPEELQNGRGF-------GYVVAFRPYGKMIW-MLTVLASADASRYVFRNESV 439
+++T LQ G GYV+ RP + +W M A+ Y + +
Sbjct: 1909 VLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKL 1968
Query: 440 HPFSPFEVKVGVFNNKGEG-PFSPTTVVYSAEEEP 473
+E +V N G G P +P+T V + E P
Sbjct: 1969 RQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
1 precursor [Homo sapiens]
Length = 1907
Score = 196 bits (498), Expect = 6e-50
Identities = 179/625 (28%), Positives = 280/625 (44%), Gaps = 53/625 (8%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTR--DRIQIEQGTLNITIVN----LSDAGMYQCLAENKH 62
C+A G PKP W+K G+ + ++ + I+ + G ++ + D +Y+C A N
Sbjct: 54 CQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSL 113
Query: 63 GVIFSNAELSVI---AVGPDF-SRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKG-- 116
G I ++A+LSV+ + P F S + ++ +V+ + C +P P +W K
Sbjct: 114 GEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFL 173
Query: 117 -RDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTA-SSTGNLVV---KDPTR 171
D N RI G L+I + +SD G Y C+ATN GT S+ NL V + R
Sbjct: 174 PVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPR 233
Query: 172 VMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDS-- 229
+PPSS +V G S+ L C V + V W E + +D
Sbjct: 234 FSIPPSSQEVMPGGSVNLTC-VAVGAPMPYV-KWMMGA------------EELTKEDEMP 279
Query: 230 AGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSW 289
G ++ + + Y C+ +S+ + A A + V+ P PP + + E T T+ L+W
Sbjct: 280 VGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTW 339
Query: 290 RPGPDNHSPITMYVIQARTPFSVG-WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVA 348
G N P+T Y IQ R + G +Q V V T ++ GL+P+ EY FR +A
Sbjct: 340 DSG--NSEPVTYYGIQYRAAGTEGPFQEVDGV------ATTRYSIGGLSPFSEYAFRVLA 391
Query: 349 ANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYV 408
N IG G PS + + RT E P P V S S +++ WE P E NG GY
Sbjct: 392 VNSIGRGPPSE-AVRARTGEQAPSSPPRRVQARMLSASTMLVQWE--PPEEPNGLVRGYR 448
Query: 409 VAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYS 468
V + P + + DA + S+ P + ++V F G+GP SPT V +
Sbjct: 449 VYYTPDSRRPPNAWHKHNTDAG-LLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKT 507
Query: 469 AEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTV 528
+ P + PA A S T I++ W P ++ RI YE+ YW ED+++ + T
Sbjct: 508 QQGVPAQ-PADFQAEVESDTRIQLSWLLPPQE---RIIMYELVYWAAEDEDQQHKV--TF 561
Query: 529 GNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSK 588
+S + +LK LY + A + G G + T+ T + PS PP ++ S S
Sbjct: 562 DPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGST 621
Query: 589 II-LNWDQVKALDNESEVKGYKVLY 612
+ ++W A + Y V Y
Sbjct: 622 TVRVSWVPPPADSRNGVITQYSVAY 646
Score = 149 bits (377), Expect = 7e-36
Identities = 162/726 (22%), Positives = 288/726 (39%), Gaps = 87/726 (11%)
Query: 9 CKANGRPKPTYKWLKNG---EPLLTRDRI-QIEQGTLNITIVNLSDAGMYQCLAENKHGV 64
C A G P P W K+ +P + RI Q+ G L I SD G Y+C+A N G
Sbjct: 156 CAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGT 215
Query: 65 IFS---NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILK 121
+S N + V V P FS + V GG V + C +P P W G + L
Sbjct: 216 RYSAPANLYVRVRRVAPRFS--IPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELT 273
Query: 122 ENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDV 181
+ + + + + L + NV +S +YTC+A + G +T + VK +P +D+
Sbjct: 274 KEDEMPVGRNV-LELSNVVRS--ANYTCVAISSLGMIEATAQVTVK-----ALPKPPIDL 325
Query: 182 TVGESIVLPCQVTHDHSLDIVFTW--------SFNGHLIDFDRDGDHFERVGGQDSAGDL 233
V E+ +T D T+ G + D +GG +
Sbjct: 326 VVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEY 385
Query: 234 MIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGP 293
R + + G+ + A + P PP V ++ +T + W P
Sbjct: 386 AFRVLAVNSIGR-------GPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPE 438
Query: 294 DNHSPITMYVI----QARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAA 349
+ + + Y + +R P + W +T L+ TV L P + Y R +A
Sbjct: 439 EPNGLVRGYRVYYTPDSRRPPNA-WHKHNTDAGLL------TTVGSLLPGITYSLRVLAF 491
Query: 350 NVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVV 409
+G G PS P+ + +T++ +P PA+ S + + ++W P+E R Y +
Sbjct: 492 TAVGDGPPS-PTIQVKTQQGVP-AQPADFQAEVESDTRIQLSWLLPPQE----RIIMYEL 545
Query: 410 AFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSA 469
+ V +S + E + P + + ++ ++ G G F+PT +A
Sbjct: 546 VYWAAEDEDQQHKVTFDPTSS---YTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTA 602
Query: 470 EEEPTKPPASIFARSLSATDIEVFWA-SPLEKNRGRIQGYEVKYWRHEDKEENARKIRTV 528
+ P+ PP + S+ +T + V W P + G I Y V Y + ++ + +
Sbjct: 603 QSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGI 662
Query: 529 GNQ-TSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNI-IWNSSD 586
+ +S + L+ Y + V+A+ G GP S+ V V T + PS PP + + +
Sbjct: 663 SREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNS 722
Query: 587 SKIILNWDQVKALDNESEVKGYKVLY----------------------RWNRQSSTSVIE 624
+ + + W +++GY+V Y +W + S E
Sbjct: 723 TAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEES----E 778
Query: 625 TNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSA 684
+T++ P + Y + + ++ GDG+ S+ PKI G T T +A
Sbjct: 779 DYETTISGLTP-ETTYSVTVAAYTTKGDGARSK----PKIVTTTGAVPGRPTMMIST-TA 832
Query: 685 ISTIMI 690
++T ++
Sbjct: 833 MNTALL 838
Score = 114 bits (286), Expect = 2e-25
Identities = 147/619 (23%), Positives = 253/619 (40%), Gaps = 60/619 (9%)
Query: 94 GGEVVIECKPKASPKPVYTW-KKGRDILKENERITISEDGNLRIINV----TKSDAGSYT 148
GG C+ PKP TW KKG+ + + + +DG ++ + + D Y
Sbjct: 47 GGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYE 106
Query: 149 CIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSL-------DI 201
C ATN G +++ L V + ++ PP + +G + + + L D
Sbjct: 107 CTATNSLGEINTSAKLSVLEEEQL--PPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDP 164
Query: 202 VFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVD-RLSAA 260
+W + +D +++ +G L I + + GKY C+ S R SA
Sbjct: 165 EISWFKDFLPVDPATSNGRIKQL----RSGALQIESSEESDQGKYECVATNSAGTRYSAP 220
Query: 261 ADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTV 320
A+L VR P I ++ ++ P +T + A P+ V W +
Sbjct: 221 ANLYVRVRRVAPRF----SIPPSSQEVM----PGGSVNLTCVAVGAPMPY-VKWMMGAEE 271
Query: 321 PELIDGKTFTATVVGLNPWVEY-EFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVS 379
D V+ L+ V + VA + +G+ E + + T +ALP+ P ++
Sbjct: 272 LTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATA----QVTVKALPK-PPIDLV 326
Query: 380 GGGGSKSELVITWETVPEELQNGRGFGYVVAFR--PYGKMIWMLTVLASADASRYVFRNE 437
+ + + +TW++ E G Y A P+ ++ + T +RY
Sbjct: 327 VTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVAT-------TRYSIGGL 379
Query: 438 SVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASP 497
S PFS + +V N+ G GP S + E+ P+ PP + AR LSA+ + V W P
Sbjct: 380 S--PFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPP 437
Query: 498 LEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGT 557
E N G ++GY V Y + NA T + +L + Y L V A+ + G
Sbjct: 438 EEPN-GLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGD 496
Query: 558 GPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRW--- 614
GP S T+ V T++ P+QP SD++I L+W L + + Y+++Y W
Sbjct: 497 GPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSW----LLPPQERIIMYELVY-WAAE 551
Query: 615 --NRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGS 672
++Q + T+ ++E L D Y ++ SD G G + I + A + S
Sbjct: 552 DEDQQHKVTFDPTSSYTLE-DLKPDTLYRFQLAARSDMGVGVFTPTI---EARTAQSTPS 607
Query: 673 GASTSNACTLSAISTIMIS 691
C +T+ +S
Sbjct: 608 APPQKVMCVSMGSTTVRVS 626
Score = 95.9 bits (237), Expect = 1e-19
Identities = 101/417 (24%), Positives = 167/417 (40%), Gaps = 32/417 (7%)
Query: 266 RGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPE--L 323
+G P P + +DT QLSW P I MY + V W A + +
Sbjct: 509 QGVPAQPADFQAEVESDTRIQLSWLLPPQER--IIMYEL-------VYWAAEDEDQQHKV 559
Query: 324 IDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGG 383
T + T+ L P Y F+ A + +G+G + P+ + RT ++ P P V
Sbjct: 560 TFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFT-PTIEARTAQSTPSAPPQKVMCVSM 618
Query: 384 SKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFS 443
+ + ++W P + +NG Y VA+ V+ + + ++
Sbjct: 619 GSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWT 678
Query: 444 PFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPL-EKNR 502
+ V V + G GP S +V + E+ P+ PP + L++T + V+W P+ K
Sbjct: 679 EYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQH 738
Query: 503 GRIQGYEVKYWRHEDKEENARKI------------RTVGNQTSTKITNLKGSVLYHLAVK 550
G+I+GY+V Y R E+ E I T I+ L Y + V
Sbjct: 739 GQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVA 798
Query: 551 AYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKV 610
AY + G G S VTT P +P +I ++ + +L W K L E+ GY++
Sbjct: 799 AYTTKGDGARSKPKIVTTTGAVPGRPT-MMISTTAMNTALLQWHPPKEL--PGELLGYRL 855
Query: 611 LYRWNRQSSTSVIETNKTSVELS---LPFDEDYIIEIKPFSDGGDGSSSE-QIRIPK 663
Y ++ + I+ K + L YI + + G G E +IR P+
Sbjct: 856 QYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPE 912
Score = 94.0 bits (232), Expect = 4e-19
Identities = 104/425 (24%), Positives = 171/425 (40%), Gaps = 36/425 (8%)
Query: 268 PPGPPEAVTIDEITDTTAQLSWRPGP-DNHSPITMYVIQARTPFSVGWQAVS------TV 320
P PP+ V + TT ++SW P P D+ + + T +SV ++AV V
Sbjct: 606 PSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVI-------TQYSVAYEAVDGEDRGRHV 658
Query: 321 PELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSG 380
+ I + + +VGL W EY A +G G S P RT+E +P P V
Sbjct: 659 VDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSP-VLVRTDEDVPSGPPRKVEV 717
Query: 381 GGGSKSELVITWETVPEELQNGRGFGYVVAF------RPYGKMIWMLTVLASA-----DA 429
+ + + + W+ Q+G+ GY V + P G I +LA A ++
Sbjct: 718 EPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEES 777
Query: 430 SRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATD 489
Y + P + + V V + KG+G S +V + P +P I +++
Sbjct: 778 EDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTAL 837
Query: 490 IEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAV 549
++ W P E G + GY ++Y R ++ N I + +T L Y +
Sbjct: 838 LQ--WHPPKEL-PGELLGYRLQYCRADEARPNT--IDFGKDDQHFTVTGLHKGTTYIFRL 892
Query: 550 KAYNSAGTGPSSATVNVTTRKPPPSQPPGNI-IWNSSDSKIILNWDQVKALDNESEVKGY 608
A N AG G + T + PS P N+ + + S L WD + + Y
Sbjct: 893 AAKNRAGLG-EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISY 951
Query: 609 KVLYR-WNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDG--SSSEQIRIPKIS 665
V++R N Q I T+ L D Y I+++ ++ G G S S Q R +
Sbjct: 952 TVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVE 1011
Query: 666 NAYAR 670
+A+
Sbjct: 1012 QVFAK 1016
Score = 63.9 bits (154), Expect = 5e-10
Identities = 63/236 (26%), Positives = 93/236 (39%), Gaps = 28/236 (11%)
Query: 269 PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELID-GK 327
PG P + I TA L W P + + Y +Q +A P ID GK
Sbjct: 821 PGRP-TMMISTTAMNTALLQWHPPKELPGELLGYRLQY-------CRADEARPNTIDFGK 872
Query: 328 TFTA-TVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKS 386
TV GL+ Y FR A N G+GE ++ RT E LP P N+ G + S
Sbjct: 873 DDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFE--KEIRTPEDLPSGFPQNLHVTGLTTS 930
Query: 387 ELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFE 446
+ W+ +NGR Y V FR + + F + P + ++
Sbjct: 931 TTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTR-----FTLTGLKPDTTYD 985
Query: 447 VKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSA-----TDIEVFWASP 497
+KV + +KG GP SP+ + T P +FA++ T + + W P
Sbjct: 986 IKVRAWTSKGSGPLSPSI------QSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVP 1035
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform
2 precursor [Homo sapiens]
Length = 1898
Score = 196 bits (498), Expect = 6e-50
Identities = 179/625 (28%), Positives = 280/625 (44%), Gaps = 53/625 (8%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTR--DRIQIEQGTLNITIVN----LSDAGMYQCLAENKH 62
C+A G PKP W+K G+ + ++ + I+ + G ++ + D +Y+C A N
Sbjct: 54 CQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSL 113
Query: 63 GVIFSNAELSVI---AVGPDF-SRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKG-- 116
G I ++A+LSV+ + P F S + ++ +V+ + C +P P +W K
Sbjct: 114 GEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFL 173
Query: 117 -RDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTA-SSTGNLVV---KDPTR 171
D N RI G L+I + +SD G Y C+ATN GT S+ NL V + R
Sbjct: 174 PVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPR 233
Query: 172 VMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDS-- 229
+PPSS +V G S+ L C V + V W E + +D
Sbjct: 234 FSIPPSSQEVMPGGSVNLTC-VAVGAPMPYV-KWMMGA------------EELTKEDEMP 279
Query: 230 AGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSW 289
G ++ + + Y C+ +S+ + A A + V+ P PP + + E T T+ L+W
Sbjct: 280 VGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTW 339
Query: 290 RPGPDNHSPITMYVIQARTPFSVG-WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVA 348
G N P+T Y IQ R + G +Q V V T ++ GL+P+ EY FR +A
Sbjct: 340 DSG--NSEPVTYYGIQYRAAGTEGPFQEVDGV------ATTRYSIGGLSPFSEYAFRVLA 391
Query: 349 ANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYV 408
N IG G PS + + RT E P P V S S +++ WE P E NG GY
Sbjct: 392 VNSIGRGPPSE-AVRARTGEQAPSSPPRRVQARMLSASTMLVQWE--PPEEPNGLVRGYR 448
Query: 409 VAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYS 468
V + P + + DA + S+ P + ++V F G+GP SPT V +
Sbjct: 449 VYYTPDSRRPPNAWHKHNTDAG-LLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKT 507
Query: 469 AEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTV 528
+ P + PA A S T I++ W P ++ RI YE+ YW ED+++ + T
Sbjct: 508 QQGVPAQ-PADFQAEVESDTRIQLSWLLPPQE---RIIMYELVYWAAEDEDQQHKV--TF 561
Query: 529 GNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSK 588
+S + +LK LY + A + G G + T+ T + PS PP ++ S S
Sbjct: 562 DPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGST 621
Query: 589 II-LNWDQVKALDNESEVKGYKVLY 612
+ ++W A + Y V Y
Sbjct: 622 TVRVSWVPPPADSRNGVITQYSVAY 646
Score = 151 bits (382), Expect = 2e-36
Identities = 160/713 (22%), Positives = 285/713 (39%), Gaps = 70/713 (9%)
Query: 9 CKANGRPKPTYKWLKNG---EPLLTRDRI-QIEQGTLNITIVNLSDAGMYQCLAENKHGV 64
C A G P P W K+ +P + RI Q+ G L I SD G Y+C+A N G
Sbjct: 156 CAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGT 215
Query: 65 IFS---NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILK 121
+S N + V V P FS + V GG V + C +P P W G + L
Sbjct: 216 RYSAPANLYVRVRRVAPRFS--IPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELT 273
Query: 122 ENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDV 181
+ + + + + L + NV +S +YTC+A + G +T + VK +P +D+
Sbjct: 274 KEDEMPVGRNV-LELSNVVRS--ANYTCVAISSLGMIEATAQVTVK-----ALPKPPIDL 325
Query: 182 TVGESIVLPCQVTHDHSLDIVFTW--------SFNGHLIDFDRDGDHFERVGGQDSAGDL 233
V E+ +T D T+ G + D +GG +
Sbjct: 326 VVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEY 385
Query: 234 MIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGP 293
R + + G+ + A + P PP V ++ +T + W P
Sbjct: 386 AFRVLAVNSIGR-------GPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPE 438
Query: 294 DNHSPITMYVI----QARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAA 349
+ + + Y + +R P + W +T L+ TV L P + Y R +A
Sbjct: 439 EPNGLVRGYRVYYTPDSRRPPNA-WHKHNTDAGLL------TTVGSLLPGITYSLRVLAF 491
Query: 350 NVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVV 409
+G G PS P+ + +T++ +P PA+ S + + ++W P+E R Y +
Sbjct: 492 TAVGDGPPS-PTIQVKTQQGVP-AQPADFQAEVESDTRIQLSWLLPPQE----RIIMYEL 545
Query: 410 AFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSA 469
+ V +S + E + P + + ++ ++ G G F+PT +A
Sbjct: 546 VYWAAEDEDQQHKVTFDPTSS---YTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTA 602
Query: 470 EEEPTKPPASIFARSLSATDIEVFWA-SPLEKNRGRIQGYEVKYWRHEDKEENARKIRTV 528
+ P+ PP + S+ +T + V W P + G I Y V Y + ++ + +
Sbjct: 603 QSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGI 662
Query: 529 GNQ-TSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNI-IWNSSD 586
+ +S + L+ Y + V+A+ G GP S+ V V T + PS PP + + +
Sbjct: 663 SREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNS 722
Query: 587 SKIILNWDQVKALDNESEVKGYKVLYRWNRQ---------SSTSVIETNKTSVELSLPFD 637
+ + + W +++GY+V Y + E +T++ P +
Sbjct: 723 TAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTP-E 781
Query: 638 EDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMI 690
Y + + ++ GDG+ S+ PKI G T T +A++T ++
Sbjct: 782 TTYSVTVAAYTTKGDGARSK----PKIVTTTGAVPGRPTMMIST-TAMNTALL 829
Score = 114 bits (286), Expect = 2e-25
Identities = 147/619 (23%), Positives = 253/619 (40%), Gaps = 60/619 (9%)
Query: 94 GGEVVIECKPKASPKPVYTW-KKGRDILKENERITISEDGNLRIINV----TKSDAGSYT 148
GG C+ PKP TW KKG+ + + + +DG ++ + + D Y
Sbjct: 47 GGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYE 106
Query: 149 CIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSL-------DI 201
C ATN G +++ L V + ++ PP + +G + + + L D
Sbjct: 107 CTATNSLGEINTSAKLSVLEEEQL--PPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDP 164
Query: 202 VFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVD-RLSAA 260
+W + +D +++ +G L I + + GKY C+ S R SA
Sbjct: 165 EISWFKDFLPVDPATSNGRIKQL----RSGALQIESSEESDQGKYECVATNSAGTRYSAP 220
Query: 261 ADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTV 320
A+L VR P I ++ ++ P +T + A P+ V W +
Sbjct: 221 ANLYVRVRRVAPRF----SIPPSSQEVM----PGGSVNLTCVAVGAPMPY-VKWMMGAEE 271
Query: 321 PELIDGKTFTATVVGLNPWVEY-EFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVS 379
D V+ L+ V + VA + +G+ E + + T +ALP+ P ++
Sbjct: 272 LTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATA----QVTVKALPK-PPIDLV 326
Query: 380 GGGGSKSELVITWETVPEELQNGRGFGYVVAFR--PYGKMIWMLTVLASADASRYVFRNE 437
+ + + +TW++ E G Y A P+ ++ + T +RY
Sbjct: 327 VTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVAT-------TRYSIGGL 379
Query: 438 SVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASP 497
S PFS + +V N+ G GP S + E+ P+ PP + AR LSA+ + V W P
Sbjct: 380 S--PFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPP 437
Query: 498 LEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGT 557
E N G ++GY V Y + NA T + +L + Y L V A+ + G
Sbjct: 438 EEPN-GLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGD 496
Query: 558 GPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRW--- 614
GP S T+ V T++ P+QP SD++I L+W L + + Y+++Y W
Sbjct: 497 GPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSW----LLPPQERIIMYELVY-WAAE 551
Query: 615 --NRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGS 672
++Q + T+ ++E L D Y ++ SD G G + I + A + S
Sbjct: 552 DEDQQHKVTFDPTSSYTLE-DLKPDTLYRFQLAARSDMGVGVFTPTI---EARTAQSTPS 607
Query: 673 GASTSNACTLSAISTIMIS 691
C +T+ +S
Sbjct: 608 APPQKVMCVSMGSTTVRVS 626
Score = 100 bits (248), Expect = 6e-21
Identities = 101/408 (24%), Positives = 168/408 (41%), Gaps = 23/408 (5%)
Query: 266 RGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPE--L 323
+G P P + +DT QLSW P I MY + V W A + +
Sbjct: 509 QGVPAQPADFQAEVESDTRIQLSWLLPPQER--IIMYEL-------VYWAAEDEDQQHKV 559
Query: 324 IDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGG 383
T + T+ L P Y F+ A + +G+G + P+ + RT ++ P P V
Sbjct: 560 TFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFT-PTIEARTAQSTPSAPPQKVMCVSM 618
Query: 384 SKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFS 443
+ + ++W P + +NG Y VA+ V+ + + ++
Sbjct: 619 GSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWT 678
Query: 444 PFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPL-EKNR 502
+ V V + G GP S +V + E+ P+ PP + L++T + V+W P+ K
Sbjct: 679 EYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQH 738
Query: 503 GRIQGYEVKYWRHEDKEENARKI---RTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGP 559
G+I+GY+V Y R E+ E I + T I+ L Y + V AY + G G
Sbjct: 739 GQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGA 798
Query: 560 SSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSS 619
S VTT P +P +I ++ + +L W K L E+ GY++ Y ++
Sbjct: 799 RSKPKIVTTTGAVPGRPT-MMISTTAMNTALLQWHPPKEL--PGELLGYRLQYCRADEAR 855
Query: 620 TSVIETNKTSVELS---LPFDEDYIIEIKPFSDGGDGSSSE-QIRIPK 663
+ I+ K + L YI + + G G E +IR P+
Sbjct: 856 PNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPE 903
Score = 93.6 bits (231), Expect = 6e-19
Identities = 103/420 (24%), Positives = 169/420 (40%), Gaps = 35/420 (8%)
Query: 268 PPGPPEAVTIDEITDTTAQLSWRPGP-DNHSPITMYVIQARTPFSVGWQAVS------TV 320
P PP+ V + TT ++SW P P D+ + + T +SV ++AV V
Sbjct: 606 PSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVI-------TQYSVAYEAVDGEDRGRHV 658
Query: 321 PELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSG 380
+ I + + +VGL W EY A +G G S P RT+E +P P V
Sbjct: 659 VDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSP-VLVRTDEDVPSGPPRKVEV 717
Query: 381 GGGSKSELVITWETVPEELQNGRGFGYVVAF------RPYGKMIWMLTVLASADASRYVF 434
+ + + + W+ Q+G+ GY V + P G I +LA A +
Sbjct: 718 EPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTI-- 775
Query: 435 RNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFW 494
+ P + + V V + KG+G S +V + P +P I +++ ++ W
Sbjct: 776 --SGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQ--W 831
Query: 495 ASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNS 554
P E G + GY ++Y R ++ N I + +T L Y + A N
Sbjct: 832 HPPKEL-PGELLGYRLQYCRADEARPNT--IDFGKDDQHFTVTGLHKGTTYIFRLAAKNR 888
Query: 555 AGTGPSSATVNVTTRKPPPSQPPGNI-IWNSSDSKIILNWDQVKALDNESEVKGYKVLYR 613
AG G + T + PS P N+ + + S L WD + + Y V++R
Sbjct: 889 AGLG-EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR 947
Query: 614 -WNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDG--SSSEQIRIPKISNAYAR 670
N Q I T+ L D Y I+++ ++ G G S S Q R + +A+
Sbjct: 948 DINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAK 1007
Score = 63.9 bits (154), Expect = 5e-10
Identities = 63/236 (26%), Positives = 93/236 (39%), Gaps = 28/236 (11%)
Query: 269 PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELID-GK 327
PG P + I TA L W P + + Y +Q +A P ID GK
Sbjct: 812 PGRP-TMMISTTAMNTALLQWHPPKELPGELLGYRLQY-------CRADEARPNTIDFGK 863
Query: 328 TFTA-TVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKS 386
TV GL+ Y FR A N G+GE ++ RT E LP P N+ G + S
Sbjct: 864 DDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFE--KEIRTPEDLPSGFPQNLHVTGLTTS 921
Query: 387 ELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFE 446
+ W+ +NGR Y V FR + + F + P + ++
Sbjct: 922 TTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTR-----FTLTGLKPDTTYD 976
Query: 447 VKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSA-----TDIEVFWASP 497
+KV + +KG GP SP+ + T P +FA++ T + + W P
Sbjct: 977 IKVRAWTSKGSGPLSPSI------QSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVP 1026
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 193 bits (491), Expect = 4e-49
Identities = 177/695 (25%), Positives = 295/695 (42%), Gaps = 45/695 (6%)
Query: 3 ENVFWECKANGRPKP-TYKWLKNGEPL-----LTRDRIQIEQGTLNITIVNLSDAGMYQC 56
+ VF C P T W K+G P+ +T D I +L I+ ++L G Y C
Sbjct: 611 QRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTS-SLRISNLSLMHNGNYTC 669
Query: 57 LAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWK-- 114
+A N+ + ++L ++ V P F + R G V++ C + P P WK
Sbjct: 670 IARNEAAAVEHQSQL-IVRVPPKF--VVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFS 726
Query: 115 KGRDI-----LKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGT-ASSTGNLVVKD 168
KG + + N RI + +G+L I +V + D+G Y C +N G S + L VK
Sbjct: 727 KGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKI 786
Query: 169 PTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQD 228
P + P++ T G+ + C T I+ W +I+ + +
Sbjct: 787 PAMITSYPNTTLATQGQKKEMSC--TAHGEKPIIVRWEKEDRIIN----PEMARYLVSTK 840
Query: 229 SAGDLMIRNIQL-----KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDT 283
G+ +I +Q+ + +G + C S L V+ PP PPE + I ++
Sbjct: 841 EVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPE-IEIKDVKAR 899
Query: 284 TAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYE 343
T L W G D +SPIT Y I+ + S W + + + + +AT++ ++P Y
Sbjct: 900 TITLRWTMGFDGNSPITGYDIECKNK-SDSWDSAQRTKD-VSPQLNSATIIDIHPSSTYS 957
Query: 344 FRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGR 403
R A N IG EPS +EA P+ P V S + +TW+ + LQNG
Sbjct: 958 IRMYAKNRIGKSEPSNELTIT-ADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGI 1016
Query: 404 GFGYVVAFRPYGK----MIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGP 459
GY + +R Y +++V S D+ Y N ++ F+ + + V N G GP
Sbjct: 1017 IRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDN--LNKFTQYGLVVQACNRAGTGP 1074
Query: 460 FSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWAS-PLEKNRGRIQGYEVKYWRHEDK 518
S + + E+ P+ PP ++ A + S I + W++ E G +QG+ V YW +
Sbjct: 1075 SSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMD 1134
Query: 519 EENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPG 578
E Q S ++ L+ Y + V A+ AG G S + T++ P P G
Sbjct: 1135 GELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAG 1194
Query: 579 NIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLP--- 635
+S S + ++W + L ++ Y V + S E + S +P
Sbjct: 1195 VKAAAASASMVFVSW--LPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLS 1252
Query: 636 FDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYAR 670
+ Y + + + G G+SSE I + ++ A AR
Sbjct: 1253 RNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPAR 1287
Score = 99.4 bits (246), Expect = 1e-20
Identities = 79/279 (28%), Positives = 120/279 (43%), Gaps = 22/279 (7%)
Query: 3 ENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQ---------GTLNITIVNLSDAGM 53
E V C G P PT W + +P+L +I Q LNI+ + D G+
Sbjct: 422 EPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGV 481
Query: 54 YQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW 113
Y+C A N GV+ A ++V GP R +K +T + G + I C+ P W
Sbjct: 482 YRCTANNSAGVVLYQARINV--RGPASIRP-MKNITAI-AGRDTYIHCRVIGYPYYSIKW 537
Query: 114 KKGRDILKENER-ITISEDGNLRIINVTKS-DAGSYTC-IATNHFGTASSTGNLVVKDPT 170
K ++L N R + +G L++ +V K D G YTC + + S + ++ VK P
Sbjct: 538 YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPP 597
Query: 171 RVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSA 230
+ P ++G+ + +PC V L I TW +G I G + D
Sbjct: 598 FIQ-PFEFPRFSIGQRVFIPCVVV-SGDLPITITWQKDGRPI----PGSLGVTIDNIDFT 651
Query: 231 GDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP 269
L I N+ L H G Y C+ + + + LIVR PP
Sbjct: 652 SSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPP 690
Score = 83.6 bits (205), Expect = 6e-16
Identities = 76/268 (28%), Positives = 117/268 (43%), Gaps = 17/268 (6%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSN 68
CKA G P+P Y+WLK+ PL R Q L I + SD+G Y C N++G +
Sbjct: 246 CKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYG---TA 302
Query: 69 AELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILK--ENERI 126
+ + V T+ R VG +V + C + +W + +IL +N RI
Sbjct: 303 KVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRI 362
Query: 127 TISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPT-RVMVPPSSMDVTVGE 185
T NL + ++ KSD G+Y C +A +V++D T +++ S V+ E
Sbjct: 363 TGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAE 422
Query: 186 SIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQ-DSAGD----LMIRNIQL 240
+ L C V I TW+ + I + G H R+ S G+ L I + Q+
Sbjct: 423 PVSLMCNVKGTPLPTI--TWTLDDDPI--LKGGSH--RISQMITSEGNVVSYLNISSSQV 476
Query: 241 KHAGKYVCMVQTSVDRLSAAADLIVRGP 268
+ G Y C S + A + VRGP
Sbjct: 477 RDGGVYRCTANNSAGVVLYQARINVRGP 504
Score = 77.0 bits (188), Expect = 5e-14
Identities = 54/183 (29%), Positives = 89/183 (48%), Gaps = 10/183 (5%)
Query: 94 GGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATN 153
G V + CK P+P Y W K L+ + R + G L I N+ SD+GSY C +N
Sbjct: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG-LLIENIRPSDSGSYVCEVSN 297
Query: 154 HFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLID 213
+GTA G L VK P + + P + +VG + L C VT ++ +W NG +++
Sbjct: 298 RYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQEL--SWYRNGEILN 355
Query: 214 FDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPE 273
++ R+ G + +L++ ++ G Y C V+ D+LSA + V G P+
Sbjct: 356 PGKN----VRITGINHE-NLIMDHMVKSDGGAYQCFVRK--DKLSAQDYVQVVLEDGTPK 408
Query: 274 AVT 276
++
Sbjct: 409 IIS 411
Score = 68.2 bits (165), Expect = 3e-11
Identities = 66/262 (25%), Positives = 110/262 (41%), Gaps = 20/262 (7%)
Query: 4 NVFWECKANGRPKPTYKWLKNGEPLLTRDRIQI---EQGTLNITIVNLS-DAGMYQCLAE 59
+ + C+ G P + KW KN LL + Q+ GTL ++ V D G Y C
Sbjct: 520 DTYIHCRVIGYPYYSIKWYKNSN-LLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVL 578
Query: 60 NKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV-YTWKKGRD 118
+ + S + + V P R + +G V I C + P+ TW+K
Sbjct: 579 VQPQLSTSQSVHVTVKVPPFIQPFEFPRFS---IGQRVFIPCVVVSGDLPITITWQKDGR 635
Query: 119 ILKENERITISE---DGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVP 175
+ + +TI +LRI N++ G+YTCIA N L+V+ P + +V
Sbjct: 636 PIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQ 695
Query: 176 PSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQD---SAGD 232
P D G++++L C IV+ +S + F + G+ S G
Sbjct: 696 PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIA-----LNGRIQVLSNGS 750
Query: 233 LMIRNIQLKHAGKYVCMVQTSV 254
L+I+++ + +G Y+C V V
Sbjct: 751 LLIKHVVEEDSGYYLCKVSNDV 772
Score = 66.6 bits (161), Expect = 7e-11
Identities = 76/335 (22%), Positives = 134/335 (40%), Gaps = 39/335 (11%)
Query: 135 RIINVTKSDAGSYTCIATNHFGTASSTGNLVV----KDPTRVMVPPSSMDVTVGESIVLP 190
RI N++++ S +A G +S+ + V K P R++ ++ + IVLP
Sbjct: 1247 RIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLP 1306
Query: 191 CQVTHDHSLDIVFTWSFNG--HLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVC 248
C+ D S + + NG L+ D F S G +IR ++ + +G Y C
Sbjct: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIF-------SNGSFIIRTVKAEDSGYYSC 1359
Query: 249 MVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQART 308
+ + +L V+ PP P +T+ + T ++ LSW PG + S I Y++Q
Sbjct: 1360 IANNNWGSDEIILNLQVQVPPDQPR-LTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSE 1418
Query: 309 PFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEE 368
S W + P +++ + W Y+F A N +G P R SE
Sbjct: 1419 DNSEQWGSFPISP---SERSYRLENLKCGTW--YKFTLTAQNGVG---PGRISE------ 1464
Query: 369 ALPEVTPANVSGGGGSKSELVITWETVPEELQ----NGRG---FGYVVAFRPYGKMIWML 421
+ E + EL + T L N G + + +RP+G +W
Sbjct: 1465 -IIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTT 1523
Query: 422 TVLASADASRYVFRNESVHPFSPFEVKVGVFNNKG 456
S S ++ + + +E+++ V N+ G
Sbjct: 1524 AQRTSLSKSYILY---DLQEATWYELQMRVCNSAG 1555
Score = 51.2 bits (121), Expect = 3e-06
Identities = 62/269 (23%), Positives = 104/269 (38%), Gaps = 40/269 (14%)
Query: 96 EVVIECKPKASPKPVYTWKKGRD----ILKENERITISEDGNLRIINVTKSDAGSYTCIA 151
++V+ CK P P W K + ++ + R +I +G+ I V D+G Y+CIA
Sbjct: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIA 1361
Query: 152 TNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTW------ 205
N++G+ NL +V VPP +TV ++ S I +W
Sbjct: 1362 NNNWGSDEIILNL------QVQVPPDQPRLTVSKTT----------SSSITLSWLPGDNG 1405
Query: 206 --SFNGHLIDFDRDGDHFERVGG---QDSAGDLMIRNIQLKHAGKYVCMVQTSV--DRLS 258
S G+++ + D E+ G S + N++ K+ Q V R+S
Sbjct: 1406 GSSIRGYILQYSEDNS--EQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRIS 1463
Query: 259 --AAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQA 316
A + + P E I T +L+ D PIT + ++ R PF G
Sbjct: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYR-PF--GTTV 1520
Query: 317 VSTVPELIDGKTFTATVVGLNPWVEYEFR 345
+T K++ + W E + R
Sbjct: 1521 WTTAQRTSLSKSYILYDLQEATWYELQMR 1549
Score = 45.4 bits (106), Expect = 2e-04
Identities = 33/94 (35%), Positives = 45/94 (47%), Gaps = 10/94 (10%)
Query: 3 ENVFWECKANGRPKPTYKWLK--NGEP-LLTRD--RIQIEQGTLNITIVNLSDAGMYQCL 57
+++ CKA G P P KW+K NG P L+T D R G+ I V D+G Y C+
Sbjct: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360
Query: 58 AENKHG--VIFSNAELSVIAVGPDFSRTLLKRVT 89
A N G I N + + V PD R + + T
Sbjct: 1361 ANNNWGSDEIILNLQ---VQVPPDQPRLTVSKTT 1391
Score = 36.6 bits (83), Expect = 0.081
Identities = 60/315 (19%), Positives = 109/315 (34%), Gaps = 38/315 (12%)
Query: 269 PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKT 328
PGPP V + + +SW P + I Y + P+ P+ +
Sbjct: 1189 PGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPD-----S 1243
Query: 329 FTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKS-- 386
F+ + L+ +Y VA G G S + T E L + PA + G+ +
Sbjct: 1244 FSYRIPNLSRNRQYSVWVVAVTSAGRGN----SSEIITVEPLAKA-PARILTFSGTVTTP 1298
Query: 387 ---ELVITWETVPEELQNGRGFGYVVAFRPYGKMIWM-----LTVLASADASRYVFRNES 438
++V+ + V + P + WM L + D R +F N S
Sbjct: 1299 WMKDIVLPCKAVGD---------------PSPAVKWMKDSNGTPSLVTIDGRRSIFSNGS 1343
Query: 439 VHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPL 498
+ G ++ + ++ + + + + +++ I + W P
Sbjct: 1344 FIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWL-PG 1402
Query: 499 EKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTG 558
+ I+GY ++Y ED E ++ S ++ NLK Y + A N G G
Sbjct: 1403 DNGGSSIRGYILQY--SEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPG 1460
Query: 559 PSSATVNVTTRKPPP 573
S + T P
Sbjct: 1461 RISEIIEAKTLGKEP 1475
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform
2 precursor [Homo sapiens]
Length = 1899
Score = 181 bits (459), Expect = 2e-45
Identities = 184/696 (26%), Positives = 298/696 (42%), Gaps = 92/696 (13%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTR--DRIQIEQGTLNITIV----NLSDAGMYQCLAENKH 62
C+A G P+P W K G+ + + + I+ + G+ ++ + D +Y+C+A N
Sbjct: 45 CQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNV 104
Query: 63 GVIFSNAELSV------------IAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV 110
G I + L+V I +GP ++ +V+ + C +P P
Sbjct: 105 GEISVSTRLTVLREDQIPRGFPTIDMGP--------QLKVVERTRTATMLCAASGNPDPE 156
Query: 111 YTWKKG---RDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTA-SSTGNLVV 166
TW K D N RI G L+I +SD G Y C+ATN GT S+ NL V
Sbjct: 157 ITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYV 216
Query: 167 ---KDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFER 223
+ P R +PP++ ++ G S+ + C V + V W D + D
Sbjct: 217 RVRRVPPRFSIPPTNHEIMPGGSVNITC-VAVGSPMPYV-KWMLGAE--DLTPEDDM--- 269
Query: 224 VGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDT 283
G ++ ++ + Y C+ +++ + A A + V+ P PP + E T T
Sbjct: 270 -----PIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT 324
Query: 284 TAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTA-TVVGLNPWVEY 342
+ L+W G N P++ Y+IQ + S + + IDG T +V GL+P+ +Y
Sbjct: 325 SITLTWDSG--NPEPVSYYIIQHKPKNS------EELYKEIDGVATTRYSVAGLSPYSDY 376
Query: 343 EFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNG 402
EFR VA N IG G PS P + +E+A P P +V S + +++ W+ PEE NG
Sbjct: 377 EFRVVAVNNIGRGPPSEPVLTQTSEQA-PSSAPRDVQARMLSSTTILVQWKE-PEE-PNG 433
Query: 403 RGFGYVVAFR---PYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGP 459
+ GY V + WM +A + + ++ P + VKV F + G+GP
Sbjct: 434 QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTI----GNLVPQKTYSVKVLAFTSIGDGP 489
Query: 460 FSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKE 519
S V + P + P + A S T I + W P I YE+ Y +D E
Sbjct: 490 LSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTPP---RSDTIANYELVY---KDGE 542
Query: 520 ENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGN 579
+ T+ TS ++ LK + LY+ + A + G G S+A ++ T + PS PP +
Sbjct: 543 HGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQD 602
Query: 580 IIWNS-SDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVI-ETNKTSVELSLPFD 637
I S S + I+++W + Y + Y T+V E +K L +P D
Sbjct: 603 ISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY-------TAVDGEDDKPHEILGIPSD 655
Query: 638 ------------EDYIIEIKPFSDGGDGSSSEQIRI 661
+Y I + +D G G S + I
Sbjct: 656 TTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLI 691
Score = 130 bits (326), Expect = 5e-30
Identities = 154/633 (24%), Positives = 261/633 (41%), Gaps = 59/633 (9%)
Query: 78 PDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW-KKGRDILKENERITISEDGNLRI 136
P F+RT + + + GG C+ P+P W KKG+ + + + +DG+ +
Sbjct: 24 PRFTRTPVDQTGVS--GGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSV 81
Query: 137 INV----TKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVM-------VPPSSMDVTVGE 185
+ + T D Y C+A+N+ G S + L V ++ + P V
Sbjct: 82 LRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTR 141
Query: 186 SIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGK 245
+ + C + + +I TW + +D + +++ +G L I + GK
Sbjct: 142 TATMLCAASGNPDPEI--TWFKDFLPVDTSNNNGRIKQL----RSGALQIEQSEESDQGK 195
Query: 246 YVCMVQTSVD-RLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVI 304
Y C+ S R SA A+L VR PP I T ++ P IT +
Sbjct: 196 YECVATNSAGTRYSAPANLYVRVRRVPPRF----SIPPTNHEIM----PGGSVNITCVAV 247
Query: 305 QARTPFSVGWQ--AVSTVPELIDGKTFTATVVGLNPWVEY-EFRTVAANVIGIGEPSRPS 361
+ P+ V W A PE D V+ LN + + VA + +G+ E +
Sbjct: 248 GSPMPY-VKWMLGAEDLTPE--DDMPIGRNVLELNDVRQSANYTCVAMSTLGVIE----A 300
Query: 362 EKRRTEEALPEVTPANVSGGGGSKSELVITWETV-PEELQNGRGFGYVVAFRPYGKMIWM 420
+ T +ALP+ P + + + +TW++ PE + Y++ +P +
Sbjct: 301 IAQITVKALPK-PPGTPVVTESTATSITLTWDSGNPEPVSY-----YIIQHKPKNSEE-L 353
Query: 421 LTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASI 480
+ +RY S P+S +E +V NN G GP S + ++E+ P+ P +
Sbjct: 354 YKEIDGVATTRYSVAGLS--PYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 411
Query: 481 FARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLK 540
AR LS+T I V W P E N G+IQGY V Y + N V + T I NL
Sbjct: 412 QARMLSSTTILVQWKEPEEPN-GQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV 470
Query: 541 GSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALD 600
Y + V A+ S G GP S+ + V T+ P QP S++ I+L+W ++
Sbjct: 471 PQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS-- 528
Query: 601 NESEVKGYKVLYRWNRQSSTSVIETNK-TSVEL-SLPFDEDYIIEIKPFSDGGDGSSSEQ 658
+ Y+++Y+ I TS L L + Y + S G G+S+ +
Sbjct: 529 --DTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAE 586
Query: 659 IRIPKISNAYARGSGASTSNACTLSAISTIMIS 691
I ++ S +CT + ++I++S
Sbjct: 587 I---SARTMQSKPSAPPQDISCTSPSSTSILVS 616
Score = 123 bits (309), Expect = 5e-28
Identities = 148/629 (23%), Positives = 248/629 (39%), Gaps = 62/629 (9%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTRD---RI-QIEQGTLNITIVNLSDAGMYQCLAENKHGV 64
C A+G P P W K+ P+ T + RI Q+ G L I SD G Y+C+A N G
Sbjct: 147 CAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVATNSAGT 206
Query: 65 IFS---NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILK 121
+S N + V V P FS + GG V I C SP P W G + L
Sbjct: 207 RYSAPANLYVRVRRVPPRFSIPPTNHE--IMPGGSVNITCVAVGSPMPYVKWMLGAEDLT 264
Query: 122 ENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDV 181
+ + I N+ +N + A +YTC+A + G + + VK + PP + V
Sbjct: 265 PEDDMPIGR--NVLELNDVRQSA-NYTCVAMSTLGVIEAIAQITVK---ALPKPPGTPVV 318
Query: 182 TVGESIVLPCQVTHDH------SLDIVFTWSFNGHLIDFDRDGDHFER--VGGQDSAGDL 233
T ES +T D S I+ N + + DG R V G D
Sbjct: 319 T--ESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDY 376
Query: 234 MIRNIQLKHAGK----YVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSW 289
R + + + G+ + QTS + P P V ++ TT + W
Sbjct: 377 EFRVVAVNNIGRGPPSEPVLTQTS-----------EQAPSSAPRDVQARMLSSTTILVQW 425
Query: 290 RPGPDNHSPI---TMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRT 346
+ + + I +Y T W + I T+ L P Y +
Sbjct: 426 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQI------TTIGNLVPQKTYSVKV 479
Query: 347 VAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFG 406
+A IG G P + T+ +P P N S++ ++++W P +
Sbjct: 480 LAFTSIGDG-PLSSDIQVITQTGVPG-QPLNFKAEPESETSILLSW--TPPRSDTIANYE 535
Query: 407 YVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVV 466
V +G+ +T+ +R + + P S + ++ + +G G +
Sbjct: 536 LVYKDGEHGEE-QRITIEPGTS-----YRLQGLKPNSLYYFRLAARSPQGLGASTAEISA 589
Query: 467 YSAEEEPTKPPASIFARSLSATDIEVFW-ASPLEKNRGRIQGYEVKYWRHEDKEENARKI 525
+ + +P+ PP I S S+T I V W P+EK G I Y +KY + +++ +I
Sbjct: 590 RTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEI 649
Query: 526 RTVGNQTST-KITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNI-IWN 583
+ + T+ + L+ Y + V A+ G GP S +V + T + PS PP + +
Sbjct: 650 LGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEA 709
Query: 584 SSDSKIILNWDQVKALDNESEVKGYKVLY 612
+ + + ++W +++GY+V Y
Sbjct: 710 VNSTSVKVSWRSPVPNKQHGQIRGYQVHY 738
Score = 110 bits (275), Expect = 4e-24
Identities = 137/636 (21%), Positives = 259/636 (40%), Gaps = 64/636 (10%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSN 68
C A G P P KW+ E L D + I + L + V S Y C+A + GVI +
Sbjct: 244 CVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQS--ANYTCVAMSTLGVIEAI 301
Query: 69 AELSVIAVG-----PDFSRTLLKRVTLVKVGGE------VVIECKPKASPKPVYTWKKGR 117
A+++V A+ P + + +TL G +I+ KPK S
Sbjct: 302 AQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNS----------E 351
Query: 118 DILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPS 177
++ KE + + + + ++ + +A N+ G + ++ + + PS
Sbjct: 352 ELYKEIDGVATTR---YSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA---PS 405
Query: 178 SMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRN 237
S V ++ + G+ + + D + + D I
Sbjct: 406 SAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 465
Query: 238 I-----QLKHAGKYVCMVQTSVDRLSAAADLIVR-GPPGPPEAVTIDEITDTTAQLSWRP 291
I Q ++ K + LS+ +I + G PG P + ++T+ LSW P
Sbjct: 466 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTP 525
Query: 292 GPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANV 351
I Y + + Q ++ P G ++ + GL P Y FR A +
Sbjct: 526 --PRSDTIANYELVYKDGEHGEEQRITIEP----GTSYR--LQGLKPNSLYYFRLAARSP 577
Query: 352 IGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAF 411
G+G S RT ++ P P ++S S + ++++W+ P E QNG Y + +
Sbjct: 578 QGLGA-STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 636
Query: 412 RPY-GKMIWMLTVLA-SADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSA 469
G+ +L +D ++Y+ E + ++ + + V + G GP S + ++ +
Sbjct: 637 TAVDGEDDKPHEILGIPSDTTKYLL--EQLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 694
Query: 470 EEEPTKPPASIFARSLSATDIEVFWASPL-EKNRGRIQGYEVKYWRHEDKEENAR-KIRT 527
E+ P+ PP + ++++T ++V W SP+ K G+I+GY+V Y R E+ E + ++
Sbjct: 695 EDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKD 754
Query: 528 V-----------GNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQP 576
V + I+ L+ Y L V AY + G G S V+T P +
Sbjct: 755 VMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK- 813
Query: 577 PGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLY 612
P +I ++ + ++ W +D ++GY++ +
Sbjct: 814 PRLVINHTQMNTALIQWH--PPVDTFGPLQGYRLKF 847
Score = 65.1 bits (157), Expect = 2e-10
Identities = 86/376 (22%), Positives = 151/376 (40%), Gaps = 43/376 (11%)
Query: 269 PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKT 328
PG P V I+ TA + W P D P+ Y R F T E + +
Sbjct: 811 PGKPRLV-INHTQMNTALIQWHPPVDTFGPLQGY----RLKFGRKDMEPLTTLEFSEKED 865
Query: 329 -FTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSE 387
FTAT ++ Y FR A N +G GE ++ E +P P N+ G + +
Sbjct: 866 HFTAT--DIHKGASYVFRLSARNKVGFGEEM--VKEISIPEEVPTGFPQNLHSEGTTSTS 921
Query: 388 LVITWETVPEELQNGRGFGYVVAFRPYG-KMIWMLTVLASADASRYVFRNESVHPFSPFE 446
+ ++W+ +NG Y + +R ++ M ++ AD + + + P + ++
Sbjct: 922 VQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTL---TGLKPDTTYD 978
Query: 447 VKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFA-----RSLSATDIEVFWASPLEKN 501
VKV +KG GP+SP+ + T P +FA +++ T + + W P +N
Sbjct: 979 VKVRAHTSKGPGPYSPSV------QFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIP--EN 1030
Query: 502 RGRIQGYEVKYWRHEDKEENARKIRTV-GNQTSTKITNLKGSVLYHLAVKAYNSAGTGPS 560
+++ Y ++ + + V G T I NLK Y + + G
Sbjct: 1031 YNSAMPFKILY-------DDGKMVEEVDGRATQKLIVNLKPEKSYSFVL---TNRGNSAG 1080
Query: 561 SATVNVTTRKPPP--SQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQS 618
VT + P P I + D I + +V A +N +KGY ++ ++S
Sbjct: 1081 GLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN---IKGYYIIIVPLKKS 1137
Query: 619 STSVIETNKTSVELSL 634
I+ ++ E+ L
Sbjct: 1138 RGKFIKPWESPDEMEL 1153
Score = 38.9 bits (89), Expect = 0.016
Identities = 38/140 (27%), Positives = 64/140 (45%), Gaps = 9/140 (6%)
Query: 268 PPGPPEAVTIDEITDTTAQLSWRPG--PDNHSPITMYVIQARTPFSVGWQAVSTVPELID 325
P G P+ + + T T+ QLSW+P + + IT Y + R ++ + + +LI
Sbjct: 905 PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-DINI---PLLPMEQLIV 960
Query: 326 GKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSK 385
T T+ GL P Y+ + A G G P PS + RT + +V N K
Sbjct: 961 PADTTMTLTGLKPDTTYDVKVRAHTSKGPG-PYSPSVQFRT-LPVDQVFAKNFHVKAVMK 1018
Query: 386 SELVITWETVPEELQNGRGF 405
+ ++++WE +PE + F
Sbjct: 1019 TSVLLSWE-IPENYNSAMPF 1037
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 174 bits (440), Expect = 3e-43
Identities = 184/709 (25%), Positives = 299/709 (42%), Gaps = 105/709 (14%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTR--DRIQIEQGTLNITIV----NLSDAGMYQCLAENKH 62
C+A G P+P W K G+ + + + I+ + G+ ++ + D +Y+C+A N
Sbjct: 45 CQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNV 104
Query: 63 GVIFSNAELSV------------IAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV 110
G I + L+V I +GP ++ +V+ + C +P P
Sbjct: 105 GEISVSTRLTVLREDQIPRGFPTIDMGP--------QLKVVERTRTATMLCAASGNPDPE 156
Query: 111 YTWKKG---RDILKENERITISED---------GNLRIINVTKSDAGSYTCIATNHFGTA 158
TW K D N RI G L+I +SD G Y C+ATN GT
Sbjct: 157 ITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTR 216
Query: 159 -SSTGNLVVKD-------PTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGH 210
S+ NL V++ P R +PP++ ++ G S+ + C V + V W
Sbjct: 217 YSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITC-VAVGSPMPYV-KWMLGAE 274
Query: 211 LIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPG 270
D + D G ++ ++ + Y C+ +++ + A A + V+ P
Sbjct: 275 --DLTPEDDM--------PIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPK 324
Query: 271 PPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFT 330
PP + E T T+ L+W G N P++ Y+IQ + S + + IDG T
Sbjct: 325 PPGTPVVTESTATSITLTWDSG--NPEPVSYYIIQHKPKNS------EELYKEIDGVATT 376
Query: 331 A-TVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELV 389
+V GL+P+ +YEFR VA N IG G PS P + +E+A P P +V S + ++
Sbjct: 377 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA-PSSAPRDVQARMLSSTTIL 435
Query: 390 ITWETVPEELQNGRGFGYVVAFR---PYGKMIWMLTVLASADASRYVFRNESVHPFSPFE 446
+ W+ PEE NG+ GY V + WM +A + + ++ P +
Sbjct: 436 VQWKE-PEE-PNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTI----GNLVPQKTYS 489
Query: 447 VKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQ 506
VKV F + G+GP S V + P + P + A S T I + W P I
Sbjct: 490 VKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTPP---RSDTIA 545
Query: 507 GYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNV 566
YE+ Y +D E + T+ TS ++ LK + LY+ + A + G G S+A ++
Sbjct: 546 NYELVY---KDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISA 602
Query: 567 TTRKPPPSQPPGNIIWNS-SDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVI-E 624
T + PS PP +I S S + I+++W + Y + Y T+V E
Sbjct: 603 RTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY-------TAVDGE 655
Query: 625 TNKTSVELSLPFD------------EDYIIEIKPFSDGGDGSSSEQIRI 661
+K L +P D +Y I + +D G G S + I
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLI 704
Score = 130 bits (327), Expect = 4e-30
Identities = 155/638 (24%), Positives = 259/638 (40%), Gaps = 56/638 (8%)
Query: 78 PDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW-KKGRDILKENERITISEDGNLRI 136
P F+RT + + + GG C+ P+P W KKG+ + + + +DG+ +
Sbjct: 24 PRFTRTPVDQTGVS--GGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSV 81
Query: 137 INV----TKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVM-------VPPSSMDVTVGE 185
+ + T D Y C+A+N+ G S + L V ++ + P V
Sbjct: 82 LRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTR 141
Query: 186 SIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHF-----ERVGGQDSAGDLMIRNIQL 240
+ + C + + +I TW + +D + E +GG G L I +
Sbjct: 142 TATMLCAASGNPDPEI--TWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 241 KHAGKYVCMVQTSVD-RLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPI 299
GKY C+ S R SA A+L VR I T ++ P I
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIM----PGGSVNI 255
Query: 300 TMYVIQARTPFSVGWQ--AVSTVPELIDGKTFTATVVGLNPWVEY-EFRTVAANVIGIGE 356
T + + P+ V W A PE D V+ LN + + VA + +G+ E
Sbjct: 256 TCVAVGSPMPY-VKWMLGAEDLTPE--DDMPIGRNVLELNDVRQSANYTCVAMSTLGVIE 312
Query: 357 PSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETV-PEELQNGRGFGYVVAFRPYG 415
+ + T +ALP+ P + + + +TW++ PE + Y++ +P
Sbjct: 313 ----AIAQITVKALPK-PPGTPVVTESTATSITLTWDSGNPEPVSY-----YIIQHKPKN 362
Query: 416 KMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTK 475
+ + +RY S P+S +E +V NN G GP S + ++E+ P+
Sbjct: 363 SEE-LYKEIDGVATTRYSVAGLS--PYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSS 419
Query: 476 PPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTK 535
P + AR LS+T I V W P E N G+IQGY V Y + N V + T
Sbjct: 420 APRDVQARMLSSTTILVQWKEPEEPN-GQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 478
Query: 536 ITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQ 595
I NL Y + V A+ S G GP S+ + V T+ P QP S++ I+L+W
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTP 538
Query: 596 VKALDNESEVKGYKVLYRWNRQSSTSVIETNK-TSVEL-SLPFDEDYIIEIKPFSDGGDG 653
++ + Y+++Y+ I TS L L + Y + S G G
Sbjct: 539 PRS----DTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG 594
Query: 654 SSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMIS 691
+S+ +I ++ S +CT + ++I++S
Sbjct: 595 ASTAEI---SARTMQSKPSAPPQDISCTSPSSTSILVS 629
Score = 112 bits (280), Expect = 1e-24
Identities = 148/642 (23%), Positives = 248/642 (38%), Gaps = 75/642 (11%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTRDRI-QIEQ------------GTLNITIVNLSDAGMYQ 55
C A+G P P W K+ P+ T + +I+Q G L I SD G Y+
Sbjct: 147 CAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYE 206
Query: 56 CLAENKHGVIFS-NAEL------SVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPK 108
C+A N G +S A L V V P FS + GG V I C SP
Sbjct: 207 CVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHE--IMPGGSVNITCVAVGSPM 264
Query: 109 PVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD 168
P W G + L + + I N+ +N + A +YTC+A + G + + VK
Sbjct: 265 PYVKWMLGAEDLTPEDDMPIGR--NVLELNDVRQSA-NYTCVAMSTLGVIEAIAQITVK- 320
Query: 169 PTRVMVPPSSMDVTVGESIVLPCQVTHDH------SLDIVFTWSFNGHLIDFDRDGDHFE 222
+ PP + VT ES +T D S I+ N + + DG
Sbjct: 321 --ALPKPPGTPVVT--ESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATT 376
Query: 223 R--VGGQDSAGDLMIRNIQLKHAGK----YVCMVQTSVDRLSAAADLIVRGPPGPPEAVT 276
R V G D R + + + G+ + QTS + P P V
Sbjct: 377 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTS-----------EQAPSSAPRDVQ 425
Query: 277 IDEITDTTAQLSWRPGPDNHSPI---TMYVIQARTPFSVGWQAVSTVPELIDGKTFTATV 333
++ TT + W+ + + I +Y T W + I T+
Sbjct: 426 ARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQI------TTI 479
Query: 334 VGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWE 393
L P Y + +A IG G P + T+ +P P N S++ ++++W
Sbjct: 480 GNLVPQKTYSVKVLAFTSIGDG-PLSSDIQVITQTGVPG-QPLNFKAEPESETSILLSW- 536
Query: 394 TVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFN 453
P + V +G+ +T+ +R + + P S + ++ +
Sbjct: 537 -TPPRSDTIANYELVYKDGEHGEE-QRITIEPGTS-----YRLQGLKPNSLYYFRLAARS 589
Query: 454 NKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFW-ASPLEKNRGRIQGYEVKY 512
+G G + + + +P+ PP I S S+T I V W P+EK G I Y +KY
Sbjct: 590 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649
Query: 513 WRHEDKEENARKIRTVGNQTST-KITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKP 571
+ +++ +I + + T+ + L+ Y + V A+ G GP S +V + T +
Sbjct: 650 TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNED 709
Query: 572 PPSQPPGNI-IWNSSDSKIILNWDQVKALDNESEVKGYKVLY 612
PS PP + + + + + ++W +++GY+V Y
Sbjct: 710 VPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHY 751
Score = 110 bits (275), Expect = 4e-24
Identities = 137/636 (21%), Positives = 259/636 (40%), Gaps = 64/636 (10%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSN 68
C A G P P KW+ E L D + I + L + V S Y C+A + GVI +
Sbjct: 257 CVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQS--ANYTCVAMSTLGVIEAI 314
Query: 69 AELSVIAVG-----PDFSRTLLKRVTLVKVGGE------VVIECKPKASPKPVYTWKKGR 117
A+++V A+ P + + +TL G +I+ KPK S
Sbjct: 315 AQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNS----------E 364
Query: 118 DILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPS 177
++ KE + + + + ++ + +A N+ G + ++ + + PS
Sbjct: 365 ELYKEIDGVATTR---YSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA---PS 418
Query: 178 SMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRN 237
S V ++ + G+ + + D + + D I
Sbjct: 419 SAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 478
Query: 238 I-----QLKHAGKYVCMVQTSVDRLSAAADLIVR-GPPGPPEAVTIDEITDTTAQLSWRP 291
I Q ++ K + LS+ +I + G PG P + ++T+ LSW P
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTP 538
Query: 292 GPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANV 351
I Y + + Q ++ P G ++ + GL P Y FR A +
Sbjct: 539 --PRSDTIANYELVYKDGEHGEEQRITIEP----GTSYR--LQGLKPNSLYYFRLAARSP 590
Query: 352 IGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAF 411
G+G S RT ++ P P ++S S + ++++W+ P E QNG Y + +
Sbjct: 591 QGLGA-STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649
Query: 412 RPY-GKMIWMLTVLA-SADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSA 469
G+ +L +D ++Y+ E + ++ + + V + G GP S + ++ +
Sbjct: 650 TAVDGEDDKPHEILGIPSDTTKYLL--EQLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 707
Query: 470 EEEPTKPPASIFARSLSATDIEVFWASPL-EKNRGRIQGYEVKYWRHEDKEENAR-KIRT 527
E+ P+ PP + ++++T ++V W SP+ K G+I+GY+V Y R E+ E + ++
Sbjct: 708 EDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKD 767
Query: 528 V-----------GNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQP 576
V + I+ L+ Y L V AY + G G S V+T P +
Sbjct: 768 VMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK- 826
Query: 577 PGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLY 612
P +I ++ + ++ W +D ++GY++ +
Sbjct: 827 PRLVINHTQMNTALIQWH--PPVDTFGPLQGYRLKF 860
Score = 65.1 bits (157), Expect = 2e-10
Identities = 86/376 (22%), Positives = 151/376 (40%), Gaps = 43/376 (11%)
Query: 269 PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKT 328
PG P V I+ TA + W P D P+ Y R F T E + +
Sbjct: 824 PGKPRLV-INHTQMNTALIQWHPPVDTFGPLQGY----RLKFGRKDMEPLTTLEFSEKED 878
Query: 329 -FTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSE 387
FTAT ++ Y FR A N +G GE ++ E +P P N+ G + +
Sbjct: 879 HFTAT--DIHKGASYVFRLSARNKVGFGEEM--VKEISIPEEVPTGFPQNLHSEGTTSTS 934
Query: 388 LVITWETVPEELQNGRGFGYVVAFRPYG-KMIWMLTVLASADASRYVFRNESVHPFSPFE 446
+ ++W+ +NG Y + +R ++ M ++ AD + + + P + ++
Sbjct: 935 VQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTL---TGLKPDTTYD 991
Query: 447 VKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFA-----RSLSATDIEVFWASPLEKN 501
VKV +KG GP+SP+ + T P +FA +++ T + + W P +N
Sbjct: 992 VKVRAHTSKGPGPYSPSV------QFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIP--EN 1043
Query: 502 RGRIQGYEVKYWRHEDKEENARKIRTV-GNQTSTKITNLKGSVLYHLAVKAYNSAGTGPS 560
+++ Y ++ + + V G T I NLK Y + + G
Sbjct: 1044 YNSAMPFKILY-------DDGKMVEEVDGRATQKLIVNLKPEKSYSFVL---TNRGNSAG 1093
Query: 561 SATVNVTTRKPPP--SQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQS 618
VT + P P I + D I + +V A +N +KGY ++ ++S
Sbjct: 1094 GLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN---IKGYYIIIVPLKKS 1150
Query: 619 STSVIETNKTSVELSL 634
I+ ++ E+ L
Sbjct: 1151 RGKFIKPWESPDEMEL 1166
Score = 38.9 bits (89), Expect = 0.016
Identities = 38/140 (27%), Positives = 64/140 (45%), Gaps = 9/140 (6%)
Query: 268 PPGPPEAVTIDEITDTTAQLSWRPG--PDNHSPITMYVIQARTPFSVGWQAVSTVPELID 325
P G P+ + + T T+ QLSW+P + + IT Y + R ++ + + +LI
Sbjct: 918 PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-DINI---PLLPMEQLIV 973
Query: 326 GKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSK 385
T T+ GL P Y+ + A G G P PS + RT + +V N K
Sbjct: 974 PADTTMTLTGLKPDTTYDVKVRAHTSKGPG-PYSPSVQFRT-LPVDQVFAKNFHVKAVMK 1031
Query: 386 SELVITWETVPEELQNGRGF 405
+ ++++WE +PE + F
Sbjct: 1032 TSVLLSWE-IPENYNSAMPF 1050
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform
3 precursor [Homo sapiens]
Length = 1903
Score = 174 bits (440), Expect = 3e-43
Identities = 184/709 (25%), Positives = 299/709 (42%), Gaps = 105/709 (14%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTR--DRIQIEQGTLNITIV----NLSDAGMYQCLAENKH 62
C+A G P+P W K G+ + + + I+ + G+ ++ + D +Y+C+A N
Sbjct: 45 CQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNV 104
Query: 63 GVIFSNAELSV------------IAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV 110
G I + L+V I +GP ++ +V+ + C +P P
Sbjct: 105 GEISVSTRLTVLREDQIPRGFPTIDMGP--------QLKVVERTRTATMLCAASGNPDPE 156
Query: 111 YTWKKG---RDILKENERITISED---------GNLRIINVTKSDAGSYTCIATNHFGTA 158
TW K D N RI G L+I +SD G Y C+ATN GT
Sbjct: 157 ITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTR 216
Query: 159 -SSTGNLVVKD-------PTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGH 210
S+ NL V++ P R +PP++ ++ G S+ + C V + V W
Sbjct: 217 YSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITC-VAVGSPMPYV-KWMLGAE 274
Query: 211 LIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPG 270
D + D G ++ ++ + Y C+ +++ + A A + V+ P
Sbjct: 275 --DLTPEDDM--------PIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPK 324
Query: 271 PPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFT 330
PP + E T T+ L+W G N P++ Y+IQ + S + + IDG T
Sbjct: 325 PPGTPVVTESTATSITLTWDSG--NPEPVSYYIIQHKPKNS------EELYKEIDGVATT 376
Query: 331 A-TVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELV 389
+V GL+P+ +YEFR VA N IG G PS P + +E+A P P +V S + ++
Sbjct: 377 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA-PSSAPRDVQARMLSSTTIL 435
Query: 390 ITWETVPEELQNGRGFGYVVAFR---PYGKMIWMLTVLASADASRYVFRNESVHPFSPFE 446
+ W+ PEE NG+ GY V + WM +A + + ++ P +
Sbjct: 436 VQWKE-PEE-PNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTI----GNLVPQKTYS 489
Query: 447 VKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQ 506
VKV F + G+GP S V + P + P + A S T I + W P I
Sbjct: 490 VKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTPP---RSDTIA 545
Query: 507 GYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNV 566
YE+ Y +D E + T+ TS ++ LK + LY+ + A + G G S+A ++
Sbjct: 546 NYELVY---KDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISA 602
Query: 567 TTRKPPPSQPPGNIIWNS-SDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVI-E 624
T + PS PP +I S S + I+++W + Y + Y T+V E
Sbjct: 603 RTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY-------TAVDGE 655
Query: 625 TNKTSVELSLPFD------------EDYIIEIKPFSDGGDGSSSEQIRI 661
+K L +P D +Y I + +D G G S + I
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLI 704
Score = 130 bits (327), Expect = 4e-30
Identities = 155/638 (24%), Positives = 259/638 (40%), Gaps = 56/638 (8%)
Query: 78 PDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW-KKGRDILKENERITISEDGNLRI 136
P F+RT + + + GG C+ P+P W KKG+ + + + +DG+ +
Sbjct: 24 PRFTRTPVDQTGVS--GGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSV 81
Query: 137 INV----TKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVM-------VPPSSMDVTVGE 185
+ + T D Y C+A+N+ G S + L V ++ + P V
Sbjct: 82 LRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTR 141
Query: 186 SIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHF-----ERVGGQDSAGDLMIRNIQL 240
+ + C + + +I TW + +D + E +GG G L I +
Sbjct: 142 TATMLCAASGNPDPEI--TWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 241 KHAGKYVCMVQTSVD-RLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPI 299
GKY C+ S R SA A+L VR I T ++ P I
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIM----PGGSVNI 255
Query: 300 TMYVIQARTPFSVGWQ--AVSTVPELIDGKTFTATVVGLNPWVEY-EFRTVAANVIGIGE 356
T + + P+ V W A PE D V+ LN + + VA + +G+ E
Sbjct: 256 TCVAVGSPMPY-VKWMLGAEDLTPE--DDMPIGRNVLELNDVRQSANYTCVAMSTLGVIE 312
Query: 357 PSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETV-PEELQNGRGFGYVVAFRPYG 415
+ + T +ALP+ P + + + +TW++ PE + Y++ +P
Sbjct: 313 ----AIAQITVKALPK-PPGTPVVTESTATSITLTWDSGNPEPVSY-----YIIQHKPKN 362
Query: 416 KMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTK 475
+ + +RY S P+S +E +V NN G GP S + ++E+ P+
Sbjct: 363 SEE-LYKEIDGVATTRYSVAGLS--PYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSS 419
Query: 476 PPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTK 535
P + AR LS+T I V W P E N G+IQGY V Y + N V + T
Sbjct: 420 APRDVQARMLSSTTILVQWKEPEEPN-GQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 478
Query: 536 ITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQ 595
I NL Y + V A+ S G GP S+ + V T+ P QP S++ I+L+W
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTP 538
Query: 596 VKALDNESEVKGYKVLYRWNRQSSTSVIETNK-TSVEL-SLPFDEDYIIEIKPFSDGGDG 653
++ + Y+++Y+ I TS L L + Y + S G G
Sbjct: 539 PRS----DTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG 594
Query: 654 SSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMIS 691
+S+ +I ++ S +CT + ++I++S
Sbjct: 595 ASTAEI---SARTMQSKPSAPPQDISCTSPSSTSILVS 629
Score = 115 bits (289), Expect = 1e-25
Identities = 137/627 (21%), Positives = 258/627 (41%), Gaps = 55/627 (8%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSN 68
C A G P P KW+ E L D + I + L + V S Y C+A + GVI +
Sbjct: 257 CVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQS--ANYTCVAMSTLGVIEAI 314
Query: 69 AELSVIAVG-----PDFSRTLLKRVTLVKVGGE------VVIECKPKASPKPVYTWKKGR 117
A+++V A+ P + + +TL G +I+ KPK S
Sbjct: 315 AQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNS----------E 364
Query: 118 DILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPS 177
++ KE + + + + ++ + +A N+ G + ++ + + PS
Sbjct: 365 ELYKEIDGVATTR---YSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA---PS 418
Query: 178 SMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRN 237
S V ++ + G+ + + D + + D I
Sbjct: 419 SAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 478
Query: 238 I-----QLKHAGKYVCMVQTSVDRLSAAADLIVR-GPPGPPEAVTIDEITDTTAQLSWRP 291
I Q ++ K + LS+ +I + G PG P + ++T+ LSW P
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTP 538
Query: 292 GPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANV 351
I Y + + Q ++ P G ++ + GL P Y FR A +
Sbjct: 539 --PRSDTIANYELVYKDGEHGEEQRITIEP----GTSYR--LQGLKPNSLYYFRLAARSP 590
Query: 352 IGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAF 411
G+G S RT ++ P P ++S S + ++++W+ P E QNG Y + +
Sbjct: 591 QGLGA-STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649
Query: 412 RPY-GKMIWMLTVLA-SADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSA 469
G+ +L +D ++Y+ E + ++ + + V + G GP S + ++ +
Sbjct: 650 TAVDGEDDKPHEILGIPSDTTKYLL--EQLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 707
Query: 470 EEEPTKPPASIFARSLSATDIEVFWASPL-EKNRGRIQGYEVKYWRHEDKEENAR---KI 525
E+ P+ PP + ++++T ++V W SP+ K G+I+GY+V Y R E+ E + K
Sbjct: 708 EDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKD 767
Query: 526 RTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSS 585
+ + I+ L+ Y L V AY + G G S V+T P + P +I ++
Sbjct: 768 VMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLVINHTQ 826
Query: 586 DSKIILNWDQVKALDNESEVKGYKVLY 612
+ ++ W +D ++GY++ +
Sbjct: 827 MNTALIQWH--PPVDTFGPLQGYRLKF 851
Score = 112 bits (281), Expect = 9e-25
Identities = 154/695 (22%), Positives = 266/695 (38%), Gaps = 83/695 (11%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTRDRI-QIEQ------------GTLNITIVNLSDAGMYQ 55
C A+G P P W K+ P+ T + +I+Q G L I SD G Y+
Sbjct: 147 CAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYE 206
Query: 56 CLAENKHGVIFS-NAEL------SVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPK 108
C+A N G +S A L V V P FS + GG V I C SP
Sbjct: 207 CVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHE--IMPGGSVNITCVAVGSPM 264
Query: 109 PVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD 168
P W G + L + + I N+ +N + A +YTC+A + G + + VK
Sbjct: 265 PYVKWMLGAEDLTPEDDMPIGR--NVLELNDVRQSA-NYTCVAMSTLGVIEAIAQITVK- 320
Query: 169 PTRVMVPPSSMDVTVGESIVLPCQVTHDH------SLDIVFTWSFNGHLIDFDRDGDHFE 222
+ PP + VT ES +T D S I+ N + + DG
Sbjct: 321 --ALPKPPGTPVVT--ESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATT 376
Query: 223 R--VGGQDSAGDLMIRNIQLKHAGK----YVCMVQTSVDRLSAAADLIVRGPPGPPEAVT 276
R V G D R + + + G+ + QTS + P P V
Sbjct: 377 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTS-----------EQAPSSAPRDVQ 425
Query: 277 IDEITDTTAQLSWRPGPDNHSPI---TMYVIQARTPFSVGWQAVSTVPELIDGKTFTATV 333
++ TT + W+ + + I +Y T W + I T+
Sbjct: 426 ARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQI------TTI 479
Query: 334 VGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWE 393
L P Y + +A IG G P + T+ +P P N S++ ++++W
Sbjct: 480 GNLVPQKTYSVKVLAFTSIGDG-PLSSDIQVITQTGVPG-QPLNFKAEPESETSILLSW- 536
Query: 394 TVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFN 453
P + V +G+ +T+ +R + + P S + ++ +
Sbjct: 537 -TPPRSDTIANYELVYKDGEHGEE-QRITIEPGTS-----YRLQGLKPNSLYYFRLAARS 589
Query: 454 NKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFW-ASPLEKNRGRIQGYEVKY 512
+G G + + + +P+ PP I S S+T I V W P+EK G I Y +KY
Sbjct: 590 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649
Query: 513 WRHEDKEENARKIRTVGNQTST-KITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKP 571
+ +++ +I + + T+ + L+ Y + V A+ G GP S +V + T +
Sbjct: 650 TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNED 709
Query: 572 PPSQPPGNI-IWNSSDSKIILNWDQVKALDNESEVKGYKVLY--------RWNRQSSTSV 622
PS PP + + + + + ++W +++GY+V Y + +
Sbjct: 710 VPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVM 769
Query: 623 IETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSE 657
+ + + L + Y + + ++ GDG+ S+
Sbjct: 770 LADAQDMIISGLQPETSYSLTVTAYTTKGDGARSK 804
Score = 65.1 bits (157), Expect = 2e-10
Identities = 86/376 (22%), Positives = 151/376 (40%), Gaps = 43/376 (11%)
Query: 269 PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKT 328
PG P V I+ TA + W P D P+ Y R F T E + +
Sbjct: 815 PGKPRLV-INHTQMNTALIQWHPPVDTFGPLQGY----RLKFGRKDMEPLTTLEFSEKED 869
Query: 329 -FTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSE 387
FTAT ++ Y FR A N +G GE ++ E +P P N+ G + +
Sbjct: 870 HFTAT--DIHKGASYVFRLSARNKVGFGEEM--VKEISIPEEVPTGFPQNLHSEGTTSTS 925
Query: 388 LVITWETVPEELQNGRGFGYVVAFRPYG-KMIWMLTVLASADASRYVFRNESVHPFSPFE 446
+ ++W+ +NG Y + +R ++ M ++ AD + + + P + ++
Sbjct: 926 VQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTL---TGLKPDTTYD 982
Query: 447 VKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFA-----RSLSATDIEVFWASPLEKN 501
VKV +KG GP+SP+ + T P +FA +++ T + + W P +N
Sbjct: 983 VKVRAHTSKGPGPYSPSV------QFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIP--EN 1034
Query: 502 RGRIQGYEVKYWRHEDKEENARKIRTV-GNQTSTKITNLKGSVLYHLAVKAYNSAGTGPS 560
+++ Y ++ + + V G T I NLK Y + + G
Sbjct: 1035 YNSAMPFKILY-------DDGKMVEEVDGRATQKLIVNLKPEKSYSFVL---TNRGNSAG 1084
Query: 561 SATVNVTTRKPPP--SQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQS 618
VT + P P I + D I + +V A +N +KGY ++ ++S
Sbjct: 1085 GLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN---IKGYYIIIVPLKKS 1141
Query: 619 STSVIETNKTSVELSL 634
I+ ++ E+ L
Sbjct: 1142 RGKFIKPWESPDEMEL 1157
Score = 38.9 bits (89), Expect = 0.016
Identities = 38/140 (27%), Positives = 64/140 (45%), Gaps = 9/140 (6%)
Query: 268 PPGPPEAVTIDEITDTTAQLSWRPG--PDNHSPITMYVIQARTPFSVGWQAVSTVPELID 325
P G P+ + + T T+ QLSW+P + + IT Y + R ++ + + +LI
Sbjct: 909 PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-DINI---PLLPMEQLIV 964
Query: 326 GKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSK 385
T T+ GL P Y+ + A G G P PS + RT + +V N K
Sbjct: 965 PADTTMTLTGLKPDTTYDVKVRAHTSKGPG-PYSPSVQFRT-LPVDQVFAKNFHVKAVMK 1022
Query: 386 SELVITWETVPEELQNGRGF 405
+ ++++WE +PE + F
Sbjct: 1023 TSVLLSWE-IPENYNSAMPF 1041
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 173 bits (439), Expect = 4e-43
Identities = 168/681 (24%), Positives = 290/681 (42%), Gaps = 50/681 (7%)
Query: 21 WLKNGEPLLTRDRIQIEQ----GTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAV 76
W K+G+ +++ + IE +L I+ V+L G Y C+A N + +L ++ V
Sbjct: 690 WRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQL-IVRV 748
Query: 77 GPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENE--------RITI 128
P F + + G V+ C P P WK + + RI I
Sbjct: 749 PPRFVVQPNNQDGIYGKAG--VLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQI 806
Query: 129 SEDGNLRIINVTKSDAGSYTCIATNHFGT-ASSTGNLVVKDPTRVMVPPSSMDVTVGESI 187
+ +L I +V + D G Y C A+N GT S + L VK P + P++ G +
Sbjct: 807 LPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAK 866
Query: 188 VLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGK-- 245
L C + I+ W +ID DR + + +D+ GD ++ ++LK A +
Sbjct: 867 ELNCTARGERP--IIIRWEKGDTVIDPDRVMRY--AIATKDN-GDEVVSTLKLKPADRGD 921
Query: 246 ---YVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMY 302
+ C S L V+ PP PPE + I E+ + L W D +S IT +
Sbjct: 922 SVFFSCHAINSYGEDRGLIQLTVQEPPDPPE-LEIREVKARSMNLRWTQRFDGNSIITGF 980
Query: 303 VIQARTPFSVGW---QAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSR 359
I+ + S W Q+ + I+ A +V L+P Y R + N IG EPS+
Sbjct: 981 DIEYKNK-SDSWDFKQSTRNISPTIN----QANIVDLHPASVYSIRMYSFNKIGRSEPSK 1035
Query: 360 PSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGK--- 416
TEEA P+ P +V+ + + +TW+ +ELQNG GY + +R
Sbjct: 1036 ELTIS-TEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSN 1094
Query: 417 -MIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTK 475
++ + A+ D+ Y N + F+ + V V FN G GP S + E+ P++
Sbjct: 1095 GQYSIVEMKATGDSEVYTLDN--LKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQ 1152
Query: 476 PPASIFARSLSATDIEVFWASPLEKN-RGRIQGYEVKYWRHEDKEENARKIRTVGNQTST 534
PP ++ A S+++ + W+ P G ++GY V +W E +
Sbjct: 1153 PPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERV 1212
Query: 535 KITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWD 594
++ ++ Y + V AY AG G S+ + + T++ P P G SS S ++++W
Sbjct: 1213 ELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSW- 1271
Query: 595 QVKALDNESEVKGYKVLYR--WNRQSSTSVIETNKTSVELSLPF---DEDYIIEIKPFSD 649
+ ++ Y + + Q + S ET+ + + + Y++ + +
Sbjct: 1272 -LPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTS 1330
Query: 650 GGDGSSSEQIRIPKISNAYAR 670
G G+SSE++ I A A+
Sbjct: 1331 AGRGNSSEKVTIEPAGKAPAK 1351
Score = 97.1 bits (240), Expect = 5e-20
Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 27/275 (9%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTL---------NITIVNLSDAGMYQCLAE 59
C A G P PT W + EP++ + Q T+ N+T + D G+Y+C A
Sbjct: 489 CAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTAR 548
Query: 60 NKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDI 119
N G A ++V GP R + + +T V G + +I C+ P W K +
Sbjct: 549 NLVGSAEYQARINVR--GPPSIRAM-RNITAV-AGRDTLINCRVIGYPYYSIKWYKDALL 604
Query: 120 LKENERITISEDGNLRIINVTKS-DAGSYTC-IATNHFGTASSTGNLVVKDPTRVM---V 174
L +N R + E+G L++ +V K D G Y C + + S + ++ VK P +
Sbjct: 605 LPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEF 664
Query: 175 PPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLM 234
PP+S +G+ + +PC V + I TW +G +I G E ++ L
Sbjct: 665 PPAS----IGQLLYIPC-VVSSGDMPIRITWRKDGQVI-ISGSGVTIE---SKEFMSSLQ 715
Query: 235 IRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP 269
I ++ LKH G Y C+ + +S LIVR PP
Sbjct: 716 ISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPP 750
Score = 87.8 bits (216), Expect = 3e-17
Identities = 73/267 (27%), Positives = 109/267 (40%), Gaps = 13/267 (4%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSN 68
C A+G P P +WLK+G PL R L I+ + D+G Y C N G S
Sbjct: 307 CTASGYPIPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTFG---SA 363
Query: 69 AELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITI 128
++ V TL + +G V++ C SP+ W + +++ +E I+I
Sbjct: 364 EATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISI 423
Query: 129 SEDGN--LRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPT-RVMVPPSSMDVTVGE 185
N L I + KS +G+Y C AT TA + ++D T R++ S V GE
Sbjct: 424 RGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGE 483
Query: 186 SIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNI---QLKH 242
L C + TW+ + I RDG H + N+ Q++
Sbjct: 484 QFSLMCAAKGAPPPTV--TWALDDEPI--VRDGSHRTNQYTMSDGTTISHMNVTGPQIRD 539
Query: 243 AGKYVCMVQTSVDRLSAAADLIVRGPP 269
G Y C + V A + VRGPP
Sbjct: 540 GGVYRCTARNLVGSAEYQARINVRGPP 566
Score = 71.6 bits (174), Expect = 2e-12
Identities = 65/235 (27%), Positives = 103/235 (43%), Gaps = 16/235 (6%)
Query: 21 WLKNGEPLLTRDRIQIE-QGTLNITIVNLSDA-GMYQCLAENKHG--VIFSNAELSVIAV 76
W K+ ++ R I G L I+ V DA Y+C+ ++K+ SN +
Sbjct: 221 WEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 280
Query: 77 GPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNL 134
+ T+L +V G V + C P P W K L + R T G L
Sbjct: 281 PAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG-L 339
Query: 135 RIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVT 194
I ++ D+G+Y C TN FG+A +TG L+V DP V + P + +G +++L C +T
Sbjct: 340 TISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALT 399
Query: 195 HDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGD-LMIRNIQLKHAGKYVC 248
S + W N L+ D E + + + + L+I + Q H+G Y C
Sbjct: 400 --GSPEFTIRWYRNTELVLPD------EAISIRGLSNETLLITSAQKSHSGAYQC 446
Score = 68.2 bits (165), Expect = 3e-11
Identities = 55/193 (28%), Positives = 87/193 (45%), Gaps = 13/193 (6%)
Query: 9 CKANGRPKPTYKWLKNGEPLLTRDR-IQIEQGTLNITIVNLS-DAGMYQCLAENKHGVIF 66
C+ G P + KW K+ L R + E GTL +T V D G Y C + +
Sbjct: 586 CRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSI 645
Query: 67 SNAELSVIAVGPDFSRTLLKRVTL--VKVGGEVVIECKPKASPKPV-YTWKKGRDILKEN 123
S + + V P L++ +G + I C + P+ TW+K ++
Sbjct: 646 SQSVHVAVKVPP-----LIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISG 700
Query: 124 ERITISED---GNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMD 180
+TI +L+I +V+ G+YTCIA+N T S L+V+ P R +V P++ D
Sbjct: 701 SGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQD 760
Query: 181 VTVGESIVLPCQV 193
G++ VL C V
Sbjct: 761 GIYGKAGVLNCSV 773
Score = 64.7 bits (156), Expect = 3e-10
Identities = 69/278 (24%), Positives = 110/278 (39%), Gaps = 25/278 (8%)
Query: 5 VFWECKANGRPKPTYKWLKNGEPLLTRDRIQI---EQGTLNITIVNLSDAGMYQCLAENK 61
V C G P+ T +W +N E +L + I I TL IT S +G YQC A K
Sbjct: 392 VILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRK 451
Query: 62 HGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKG----- 116
A +++ P + ++V V G + + C K +P P TW
Sbjct: 452 AQTAQDFAIIALEDGTPRIVSSFSEKV--VNPGEQFSLMCAAKGAPPPTVTWALDDEPIV 509
Query: 117 RDILKENERITISEDGNLRIINVTK---SDAGSYTCIATNHFGTASSTGNLVVKDPTRVM 173
RD + T+S+ + +NVT D G Y C A N G+A + V+ P +
Sbjct: 510 RDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIR 569
Query: 174 VPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDL 233
++ G ++ C+V I W + L+ + FE G L
Sbjct: 570 A-MRNITAVAGRDTLINCRVIGYPYYSI--KWYKDALLLPDNHRQVVFEN-------GTL 619
Query: 234 MIRNIQL-KHAGKYVCMVQTSVD-RLSAAADLIVRGPP 269
+ ++Q G+Y+C V +S + + V+ PP
Sbjct: 620 KLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPP 657
Score = 47.8 bits (112), Expect = 4e-05
Identities = 68/281 (24%), Positives = 109/281 (38%), Gaps = 34/281 (12%)
Query: 9 CKANGRPKPTYKW-LKNGEPLLTRDRIQIEQGTLNITIVNLSDAGM--------YQCLAE 59
C A G P +W L G+ + I+ + + S + Y C AE
Sbjct: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAE 166
Query: 60 NKHGVIFS-NAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKP---VYTWKK 115
N G I S N + + P R +R G V +C +S + V +W+K
Sbjct: 167 NAAGKIRSPNIRVKAVFREPYTVRVEDQRSMR---GNVAVFKCLIPSSVQEYVSVVSWEK 223
Query: 116 GRDILKENERITISEDGNLRIINVTKSDA-GSYTCIATNHFG--TASSTG-NLVVKDPTR 171
+ R I+ G L I +V K DA +Y CI + + T S G L V DP
Sbjct: 224 DTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAE 283
Query: 172 ----VMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQ 227
++ S +V G ++ LPC + + + + W +G D +R+ G
Sbjct: 284 SIPTILDGFHSQEVWAGHTVELPCTAS-GYPIPAI-RWLKDGR--PLPADSRWTKRITG- 338
Query: 228 DSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGP 268
L I +++ + +G Y+C V + A L+V P
Sbjct: 339 -----LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDP 374
Score = 46.2 bits (108), Expect = 1e-04
Identities = 67/282 (23%), Positives = 106/282 (37%), Gaps = 49/282 (17%)
Query: 96 EVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIIN---------VTKSDAGS 146
+V + C P P W K E+ I +S DG+ R+I+ V D+G
Sbjct: 1366 DVRLPCNSVGDPAPAVKWTKD----SEDSAIPVSMDGH-RLIHTNGTLLLRAVKAEDSGY 1420
Query: 147 YTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTW- 205
YTC ATN G + NL+V+ VPP +TV ++ + I TW
Sbjct: 1421 YTCTATNTGGFDTIIVNLLVQ------VPPDQPRLTVSKT----------SASSITLTWI 1464
Query: 206 -------SFNGHLIDFDRD-GDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSV--D 255
S G ++ + D + ++ V S + +++ K + SV
Sbjct: 1465 PGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSG 1524
Query: 256 RLSAAADLIVRG--PPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVG 313
R+S + G P + I T A+L+ + + PIT V++ R +
Sbjct: 1525 RISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWA 1584
Query: 314 WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIG 355
WQ + G+ F + L YE R A N G G
Sbjct: 1585 WQGLRANS---SGEVF---LTELREATWYELRMRACNSAGCG 1620
Score = 38.5 bits (88), Expect = 0.021
Identities = 29/98 (29%), Positives = 41/98 (41%), Gaps = 11/98 (11%)
Query: 9 CKANGRPKPTYKWLKNGEPL-----LTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHG 63
C + G P P KW K+ E + R+ GTL + V D+G Y C A N G
Sbjct: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
Query: 64 VIFSNAELSVIAVGPD-----FSRTLLKRVTLVKVGGE 96
L ++ V PD S+T +TL + G+
Sbjct: 1431 FDTIIVNL-LVQVPPDQPRLTVSKTSASSITLTWIPGD 1467
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 166 bits (421), Expect = 5e-41
Identities = 170/684 (24%), Positives = 272/684 (39%), Gaps = 62/684 (9%)
Query: 1 MEENVFWECKANGRPKPTYKWLKNGE---PLLTRDRIQI-EQGTLNITIVNLSDAGMYQC 56
M + V +C+ G P PT W KN + P+ R+ + G L I+ + D G+Y+C
Sbjct: 153 MGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRC 212
Query: 57 LAENKHGVIFSNAELSVIAVGPDFSRTL--LKRVTLVKV--GGEVVIECKPKASPKPVYT 112
A N N I P R L L+R + V G + V+EC P P +T
Sbjct: 213 SARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFT 272
Query: 113 WKKGRDILK-ENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTR 171
W +G ++++ +++ ++ NL I NVT D+G YTC+ T S++ L V P
Sbjct: 273 WLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPW 332
Query: 172 VMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAG 231
+ PS++ I C V+ + W NG ++ D+F+ VGG
Sbjct: 333 FLNHPSNLYAYESMDIEFECTVSGKPVPTV--NWMKNGDVV---IPSDYFQIVGG----S 383
Query: 232 DLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGP--------PGPPEAVTIDEITDT 283
+L I + G Y C+ + +A LIV P P P V ++
Sbjct: 384 NLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSR 443
Query: 284 TAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYE 343
+LSWRP + I + + +A++T + TV L P Y
Sbjct: 444 FVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTT----QPGSLQLTVGNLKPEAMYT 499
Query: 344 FRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGR 403
FR VA N G GE S+P + E N+ S + ++ITWE P NG
Sbjct: 500 FRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWE--PPAYANGP 557
Query: 404 GFGYVVAFRPYGKMIWMLTVLASADASRYV----FRNESVHPFSPFEVKVGVFNNKGEGP 459
GY ++ V + + V ++ E + F+ + ++ +N G G
Sbjct: 558 VQGY---------RLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGV 608
Query: 460 FSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLE-KNRGRIQGYEVKYWRHEDK 518
+ V + + P+ PP ++ +++ I+V W P G I GY++ RH
Sbjct: 609 STDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI---RHRKT 665
Query: 519 EENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTT------RKPP 572
N T L+ Y V A GTGP S T
Sbjct: 666 TRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQV 725
Query: 573 PSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKT---S 629
P Q P ++ + II++W L+ V+GY + Y + +V +K S
Sbjct: 726 PDQ-PSSLHVRPQTNCIIMSW--TPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYS 782
Query: 630 VELSLPFDEDYIIEIKPFSDGGDG 653
+E L Y+I +K F++ G+G
Sbjct: 783 IE-RLESSSHYVISLKAFNNAGEG 805
Score = 141 bits (355), Expect = 2e-33
Identities = 157/602 (26%), Positives = 245/602 (40%), Gaps = 65/602 (10%)
Query: 8 ECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSD--AGMYQCLAENKHGVI 65
EC +G P P++ WL+ E + R + G N+ I N++D +GMY C+ K+ I
Sbjct: 260 ECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENI 319
Query: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENER 125
++AEL+V+ V P F + ++ EC P P W K D++ ++
Sbjct: 320 SASAELTVL-VPPWFLNHPSNLYAYESM--DIEFECTVSGKPVPTVNWMKNGDVVIPSDY 376
Query: 126 ITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGE 185
I NLRI+ V KSD G Y C+A N G A ++ L+V P +P SS+ +
Sbjct: 377 FQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPA---IPSSSVLPSAPR 433
Query: 186 SIVLPCQVTHDHSLDIVFTW--------SFNGHLIDFDRDGDHFERVGGQDSAGDLMIRN 237
+V P V+ S + +W + + F R+GD+ ER G L +
Sbjct: 434 DVV-PVLVS---SRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTV 489
Query: 238 IQLKHAGKYVCMV----------QTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQL 287
LK Y V + +++ +L V PGP E + + T+ +
Sbjct: 490 GNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQV---PGPVENLQAVSTSPTSILI 546
Query: 288 SWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTV 347
+W P + P+ Y + T S G + V DG ++ + GL + EY R +
Sbjct: 547 TWEPPAYANGPVQGYRLFC-TEVSTGKEQNIEV----DGLSY--KLEGLKKFTEYSLRFL 599
Query: 348 AANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGY 407
A N G G S T +P P NVS + + ++W P QNG GY
Sbjct: 600 AYNRYGPG-VSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGY 658
Query: 408 VVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVY 467
+ R + M T+ + + + + S + +V G GP S
Sbjct: 659 KIRHRKTTRRGEMETL----EPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAE 714
Query: 468 SAE---EEPTKP--PASIFARSLSATDIEVFWASPLEKN---RGRIQGYEVKYWRHEDKE 519
+ E +E P P+S+ R I + W PL N RG I GY V
Sbjct: 715 TPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPLNPNIVVRGYIIGYGV-------GS 766
Query: 520 ENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTG----PSSATVNVTTRKPPPSQ 575
A +R Q I L+ S Y +++KA+N+AG G S+ T ++T P
Sbjct: 767 PYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDY 826
Query: 576 PP 577
P
Sbjct: 827 YP 828
Score = 109 bits (272), Expect = 1e-23
Identities = 166/693 (23%), Positives = 264/693 (38%), Gaps = 80/693 (11%)
Query: 4 NVFWECKANG-RPKPTYKWLKNGEPL---LTRDRIQIEQGTLNITIVNLS-----DAGMY 54
NV +C A R P KW K+G L + + Q+ G+L I + S D G+Y
Sbjct: 56 NVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLY 115
Query: 55 QCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWK 114
QC A + V GP + + VT +G V+++C+ P P W+
Sbjct: 116 QCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAF-MGDTVLLKCEVIGEPMPTIHWQ 174
Query: 115 KGRDILKE---NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGN----LVVK 167
K + L + R+ + G L+I + D G Y C A N +S TGN ++
Sbjct: 175 KNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNP--ASSRTGNEAEVRILS 232
Query: 168 DP-----TRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFE 222
DP + PS++ G+ VL C V+ FTW +I +
Sbjct: 233 DPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPS--FTWLRGEEVIQLR--SKKYS 288
Query: 223 RVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP---GPPEAVTIDE 279
+GG + L+I N+ +G Y C+V + +SA+A+L V PP P + E
Sbjct: 289 LLGGSN----LLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYE 344
Query: 280 ITDTTAQ--LSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVP------ELIDGKTFTA 331
D + +S +P P +V W V +++ G
Sbjct: 345 SMDIEFECTVSGKPVP-----------------TVNWMKNGDVVIPSDYFQIVGGSNLR- 386
Query: 332 TVVGLNPWVEYEFRTVAANVIGIGEPSR----PSEKRRTEEALPEVTPANVSGGGGSKSE 387
++G+ E ++ VA N G + S P + LP P +V S
Sbjct: 387 -ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSA-PRDVVPVLVSSRF 444
Query: 388 LVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEV 447
+ ++W E N + F V F G L + ++ P + +
Sbjct: 445 VRLSWRPPAEAKGNIQTF--TVFFSREGDN--RERALNTTQPGSLQLTVGNLKPEAMYTF 500
Query: 448 KVGVFNNKGEGPFS-PTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQ 506
+V +N G G S P V E + P ++ A S S T I + W P N G +Q
Sbjct: 501 RVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYAN-GPVQ 559
Query: 507 GYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNV 566
GY + +E ++ + S K+ LK Y L AYN G G S+ + V
Sbjct: 560 GYRLFCTEVSTGKEQNIEV----DGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITV 615
Query: 567 TTRKPPPSQPPGNIIWNSSDSKII-LNWDQVKALDNESEVKGYKVLYR-WNRQSSTSVIE 624
T PS PP N+ +S+ I ++W + + GYK+ +R R+ +E
Sbjct: 616 VTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLE 675
Query: 625 TNKT-SVELSLPFDEDYIIEIKPFSDGGDGSSS 656
N + L Y ++ + G G S
Sbjct: 676 PNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPS 708
Score = 49.3 bits (116), Expect = 1e-05
Identities = 69/316 (21%), Positives = 118/316 (37%), Gaps = 47/316 (14%)
Query: 287 LSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRT 346
+SW P + + + Y+I + VG TV +D K ++ L Y
Sbjct: 743 MSWTPPLNPNIVVRGYIIG----YGVGSPYAETVR--VDSKQRYYSIERLESSSHYVISL 796
Query: 347 VAANVIGIGEPSRPSEKRRT----------------------EEALPEVTPANVSGGGGS 384
A N G G P S R+ + + P + P V +
Sbjct: 797 KAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALT 856
Query: 385 KSELVITW--ETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASA-----DASRYVFRNE 437
+ ++W +VP+ + Y V W + ASA D + +
Sbjct: 857 HDAVRVSWADNSVPKNQKTSEVRLYTVR--------WRTSFSASAKYKSEDTTSLSYTAT 908
Query: 438 SVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPA--SIFARSLSATDIEVFWA 495
+ P + +E V V N+ +S T + E PT P ++ R + V W
Sbjct: 909 GLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQ 968
Query: 496 SPLEKNRGRIQGYEVKYWRHEDKEENARKIRTV-GNQTSTKITNLKGSVLYHLAVKAYNS 554
PLE N G+I Y + Y ++ + + T+ G++ + +I +L +Y+ ++A NS
Sbjct: 969 PPLEAN-GKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNS 1027
Query: 555 AGTGPSSATVNVTTRK 570
G GP S + T K
Sbjct: 1028 KGVGPLSDPILFRTLK 1043
Score = 41.6 bits (96), Expect = 0.003
Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 10/110 (9%)
Query: 94 GGEVVIECKPKASPK-PVYTWKKG--RDILKENERITISEDGNLRIINVT-----KSDAG 145
GG V+++C ++ PV WKK L +ER +G+L I N+ K D G
Sbjct: 54 GGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEG 113
Query: 146 SYTCIAT--NHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQV 193
Y C A+ + S T + V P R + S+ +G++++L C+V
Sbjct: 114 LYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEV 163
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,896,153
Number of Sequences: 37866
Number of extensions: 1386541
Number of successful extensions: 10946
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 294
Number of HSP's successfully gapped in prelim test: 224
Number of HSP's that attempted gapping in prelim test: 3524
Number of HSP's gapped (non-prelim): 3281
length of query: 698
length of database: 18,247,518
effective HSP length: 109
effective length of query: 589
effective length of database: 14,120,124
effective search space: 8316753036
effective search space used: 8316753036
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.