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Search of human proteins with 28373119
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
(1007 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens] 2061 0.0
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens] 2053 0.0
gi|4827022 contactin 2 precursor [Homo sapiens] 985 0.0
gi|28373129 contactin 5 isoform short [Homo sapiens] 899 0.0
gi|7657359 contactin 5 isoform long [Homo sapiens] 894 0.0
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 878 0.0
gi|75709184 contactin 3 [Homo sapiens] 877 0.0
gi|7657361 contactin 6 [Homo sapiens] 821 0.0
gi|28373126 contactin 4 isoform c precursor [Homo sapiens] 617 e-176
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens] 365 e-100
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens] 365 e-100
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens] 357 4e-98
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 345 1e-94
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 345 1e-94
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 345 2e-94
gi|27894376 cell adhesion molecule with homology to L1CAM precur... 344 3e-94
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens] 337 3e-92
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 312 9e-85
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 308 2e-83
gi|119220552 sidekick 1 [Homo sapiens] 282 1e-75
gi|222352127 sidekick 2 [Homo sapiens] 245 1e-64
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 225 1e-58
gi|237858682 neurofascin isoform 6 precursor [Homo sapiens] 219 8e-57
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] 219 8e-57
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 201 2e-51
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 201 2e-51
gi|28373124 contactin 4 isoform b precursor [Homo sapiens] 198 2e-50
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 197 3e-50
gi|157311649 neogenin homolog 1 [Homo sapiens] 191 4e-48
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 184 5e-46
>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
Length = 1007
Score = 2061 bits (5340), Expect = 0.0
Identities = 1007/1007 (100%), Positives = 1007/1007 (100%)
Query: 1 MKMWLLVSHLVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASP 60
MKMWLLVSHLVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASP
Sbjct: 1 MKMWLLVSHLVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASP 60
Query: 61 FPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLS 120
FPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLS
Sbjct: 61 FPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLS 120
Query: 121 FGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQ 180
FGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQ
Sbjct: 121 FGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQ 180
Query: 181 TNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDV 240
TNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDV
Sbjct: 181 TNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDV 240
Query: 241 YALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECE 300
YALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECE
Sbjct: 241 YALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECE 300
Query: 301 AENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAY 360
AENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAY
Sbjct: 301 AENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAY 360
Query: 361 HKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGR 420
HKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGR
Sbjct: 361 HKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGR 420
Query: 421 VIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRG 480
VIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRG
Sbjct: 421 VIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRG 480
Query: 481 KANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNK 540
KANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNK
Sbjct: 481 KANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNK 540
Query: 541 ENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLR 600
ENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLR
Sbjct: 541 ENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLR 600
Query: 601 IEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDL 660
IEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDL
Sbjct: 601 IEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDL 660
Query: 661 IPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLS 720
IPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLS
Sbjct: 661 IPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLS 720
Query: 721 REYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKG 780
REYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKG
Sbjct: 721 REYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKG 780
Query: 781 DGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKE 840
DGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKE
Sbjct: 781 DGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKE 840
Query: 841 EAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRI 900
EAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRI
Sbjct: 841 EAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRI 900
Query: 901 ISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGE 960
ISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGE
Sbjct: 901 ISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGE 960
Query: 961 YVVEVRAHSDGGDGVVSQVKISGAPTLSPSLLGLLLPAFGILVYLEF 1007
YVVEVRAHSDGGDGVVSQVKISGAPTLSPSLLGLLLPAFGILVYLEF
Sbjct: 961 YVVEVRAHSDGGDGVVSQVKISGAPTLSPSLLGLLLPAFGILVYLEF 1007
>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
Length = 1018
Score = 2053 bits (5318), Expect = 0.0
Identities = 1007/1018 (98%), Positives = 1007/1018 (98%), Gaps = 11/1018 (1%)
Query: 1 MKMWLLVSHLVIISITTCLA-----------VSEEDKGFGPIFEEQPINTIYPEESLEGK 49
MKMWLLVSHLVIISITTCLA VSEEDKGFGPIFEEQPINTIYPEESLEGK
Sbjct: 1 MKMWLLVSHLVIISITTCLAEFTWYRRYGHGVSEEDKGFGPIFEEQPINTIYPEESLEGK 60
Query: 50 VSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNY 109
VSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNY
Sbjct: 61 VSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNY 120
Query: 110 GMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVF 169
GMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVF
Sbjct: 121 GMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVF 180
Query: 170 ITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPY 229
ITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPY
Sbjct: 181 ITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPY 240
Query: 230 PADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNI 289
PADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNI
Sbjct: 241 PADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNI 300
Query: 290 QLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIP 349
QLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIP
Sbjct: 301 QLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIP 360
Query: 350 TIRWLKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPM 409
TIRWLKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPM
Sbjct: 361 TIRWLKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPM 420
Query: 410 KKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGG 469
KKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGG
Sbjct: 421 KKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGG 480
Query: 470 IYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVW 529
IYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVW
Sbjct: 481 IYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVW 540
Query: 530 SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVV 589
SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVV
Sbjct: 541 SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVV 600
Query: 590 RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIE 649
RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIE
Sbjct: 601 RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIE 660
Query: 650 GNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRN 709
GNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRN
Sbjct: 661 GNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRN 720
Query: 710 RELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAF 769
RELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAF
Sbjct: 721 RELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAF 780
Query: 770 QVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESY 829
QVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESY
Sbjct: 781 QVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESY 840
Query: 830 QIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFT 889
QIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFT
Sbjct: 841 QIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFT 900
Query: 890 KKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKH 949
KKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKH
Sbjct: 901 KKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKH 960
Query: 950 SIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGAPTLSPSLLGLLLPAFGILVYLEF 1007
SIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGAPTLSPSLLGLLLPAFGILVYLEF
Sbjct: 961 SIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGAPTLSPSLLGLLLPAFGILVYLEF 1018
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 985 bits (2546), Expect = 0.0
Identities = 507/996 (50%), Positives = 671/996 (67%), Gaps = 26/996 (2%)
Query: 5 LLVSHLVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVY 64
LLV+ + ++S + + FGP+FE+QP++ ++PEES E +V L CRARASP Y
Sbjct: 12 LLVAAVALVSSSAWSSALGSQTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATY 71
Query: 65 KWRMNNGDVDLT-SDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGY 123
+W+MN ++ L R+ +VGGNLVI NP K +DAG+Y CLASN G V S EA L FG+
Sbjct: 72 RWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGF 131
Query: 124 LDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNG 183
L F EER V+ EG G++L C+PP H+P LSYRWLLNEFP FI D R FVSQT G
Sbjct: 132 LQEFSKEERDPVKAHEGWGVMLPCNPPAHYPG-LSYRWLLNEFPNFIPTDGRHFVSQTTG 190
Query: 184 NLYIANVEASDKGNYSCFVSSPS--ITKSVFSKFIPLIPIPERTTKPYPADIVVQFK-DV 240
NLYIA ASD GNYSC +S TKSVFSKF L + T+ + I +F +
Sbjct: 191 NLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQL-NLAAEDTRLFAPSIKARFPAET 249
Query: 241 YALMGQNVTLECFALGNPVPDIRWRKV---LEPMPSTAEISTSGAVLKIFNIQLEDEGIY 297
YAL+GQ VTLECFA GNPVP I+WRKV L P +TAE L+I ++ EDEG Y
Sbjct: 250 YALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAE-----PTLQIPSVSFEDEGTY 304
Query: 298 ECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNG 357
ECEAEN +G+D Q RI VQA PEW++ I+DTE DIGS+L W C A GKP PT+RWL+NG
Sbjct: 305 ECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNG 364
Query: 358 YAYHK--------GELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPM 409
G+LR ++ E++GMYQC+AEN +G IYA+AEL + ALAP F +NP+
Sbjct: 365 EPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPV 424
Query: 410 KKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGG 469
++ I AA+GG ++I C+P+AAPK WSKGTE LVNSSR+ + DG+L I NI+R+D G
Sbjct: 425 RRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEG 484
Query: 470 IYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVW 529
YTCFAEN GKANSTG L + D T+I LAP +ADI +G+N T+QC AS DP +DLTF W
Sbjct: 485 KYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTW 544
Query: 530 SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVV 589
+ + + IDF+K HY+R + ++ G+L I NAQL+H G+YTC AQT+VD++S A ++V
Sbjct: 545 TLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLV 604
Query: 590 RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIE 649
RGPPGPPGG+ + DI T++ L+WSRG DNHSPI+KYT+Q +T + WK +T+P IE
Sbjct: 605 RGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIE 664
Query: 650 GNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRN 709
GN E A+ + L PWM+YEFRV+A+N LG GEPS PS++I+T AAP+VAPS + GGGG
Sbjct: 665 GNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAP 724
Query: 710 RELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAF 769
EL + W P+SREY G+ FGY+++F+ W+ V D +V+ +E++ P T F
Sbjct: 725 GELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPF 784
Query: 770 QVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHV---LEKIV 826
+VK++++N +GDGP SL A++ SA++ P APT+V K +SSSE++V WE V + I+
Sbjct: 785 EVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGIL 844
Query: 827 ESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIE 886
Y+IRYW A DKE AA+RV+ + SAR+ L P+T+Y + V A N AG GP S
Sbjct: 845 LGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSAN 904
Query: 887 AFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYST 946
A T K PP +PP IS S S I WD VV NES VTGYK+LY+ D L+ T
Sbjct: 905 ATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLT 964
Query: 947 HKHSIEVPIPRD-GEYVVEVRAHSDGGDGVVSQVKI 981
K+ IE+P+P D G +V++R GGDG+ ++V I
Sbjct: 965 GKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHI 1000
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 899 bits (2323), Expect = 0.0
Identities = 456/985 (46%), Positives = 619/985 (62%), Gaps = 17/985 (1%)
Query: 10 LVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMN 69
++ +S+T CL+ S + +GP+F ++P + I+P +S E KV+LNC R +P P Y+W N
Sbjct: 8 MLFLSVTMCLSESVD---YGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRN 64
Query: 70 NGDVDLTSD-RYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFP 128
++DL SD RYS++ G +I+NP + KD+G Y CLA+N G + S EATL F YL F
Sbjct: 65 GTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFS 124
Query: 129 PEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIA 188
R V V+EG+G+VL+C PP H P+ + Y W+ NEFP F+ D RRF+SQ GNLYI+
Sbjct: 125 GRTRSAVSVREGQGVVLMCSPPPHSPE-IIYSWVFNEFPSFVAEDSRRFISQETGNLYIS 183
Query: 189 NVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFK-DVYALMGQN 247
V+ SD G+Y C V + V S PL + Y I V F V A G
Sbjct: 184 KVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTT 243
Query: 248 VTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGK 307
V +ECFALGNPVP I W KV +PS A + S AVL+I N+QL+D GIYEC AEN RGK
Sbjct: 244 VKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGK 303
Query: 308 DKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYH------ 361
+ + ++ V +P WVE +NDT++D GS L W C ATGKP PT RWLKNG
Sbjct: 304 NSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVE 363
Query: 362 --KGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGG 419
G L +++V +AGMYQC+AEN YGAIYA+AELKILA APTF +N +KK I+ K
Sbjct: 364 MVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQ 423
Query: 420 RVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNR 479
V+IECKP+ +PKP SW KG + + RI I DGSL I N +++D G Y C EN
Sbjct: 424 EVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVF 483
Query: 480 GKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFN 539
G A +L + +PTRI L P ++TVGE+ + C A D +LD+TF W+ G IDF
Sbjct: 484 GSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFE 543
Query: 540 KENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGL 599
+E H++ S+ +L+IRN L HAGRY C QT D+ S A+L+VRGPPGPPG +
Sbjct: 544 EEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIV 603
Query: 600 RIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVD 659
+E+I ++ L+WS +DNHSPIS Y +Q ++ S W+ KT P II G+ME+A AVD
Sbjct: 604 IVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVD 663
Query: 660 LIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPL 719
L PW+EYEFRVVATN +G G+PS PS I+T+ A P AP++V G GR EL I W P+
Sbjct: 664 LNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPV 723
Query: 720 SREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNK 779
S E+ G FGYIVAF+P WK+ VT+ + +++++DE++ P T F+VKV +NNK
Sbjct: 724 SEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNK 783
Query: 780 GDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKI--VESYQIRYWAAH 837
GDGP+S + VI SA+ PS APT+V +S SEI V W+H+ E + + +++ YW
Sbjct: 784 GDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDM 843
Query: 838 DKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQP 897
++E+ A V+ E L L +T Y V A N AG GPPS + A TKK+PPSQ
Sbjct: 844 EQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQA 903
Query: 898 PRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPR 957
P + + GS+ + W+ V+ L+NES V GYKV YR +G + ++ T K VP+P
Sbjct: 904 PSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPD 963
Query: 958 DGEYVVEVRAHSDGGDGVV-SQVKI 981
G Y++EVRA+S+GGDG SQ+++
Sbjct: 964 AGVYIIEVRAYSEGGDGTASSQIRV 988
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 894 bits (2309), Expect = 0.0
Identities = 452/972 (46%), Positives = 610/972 (62%), Gaps = 14/972 (1%)
Query: 23 EEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSD-RYS 81
+E +GP+F ++P + I+P +S E KV+LNC R +P P Y+W N ++DL SD RYS
Sbjct: 92 DESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYS 151
Query: 82 MVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGK 141
++ G +I+NP + KD+G Y CLA+N G + S EATL F YL F R V V+EG+
Sbjct: 152 LIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQ 211
Query: 142 GMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCF 201
G+VL+C PP H P+ + Y W+ NEFP F+ D RRF+SQ GNLYI+ V+ SD G+Y C
Sbjct: 212 GVVLMCSPPPHSPE-IIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICL 270
Query: 202 VSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFK-DVYALMGQNVTLECFALGNPVP 260
V + V S PL + Y I V F V A G V +ECFALGNPVP
Sbjct: 271 VKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVP 330
Query: 261 DIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFP 320
I W KV +PS A + S AVL+I N+QL+D GIYEC AEN RGK+ + ++ V +P
Sbjct: 331 TITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYP 390
Query: 321 EWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYH--------KGELRLYDVTF 372
WVE +NDT++D GS L W C ATGKP PT RWLKNG G L +++V
Sbjct: 391 HWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQ 450
Query: 373 ENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPK 432
+AGMYQC+AEN YGAIYA+AELKILA APTF +N +KK I+ K V+IECKP+ +PK
Sbjct: 451 SDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPK 510
Query: 433 PKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITD 492
P SW KG + + RI I DGSL I N +++D G Y C EN G A +L + +
Sbjct: 511 PTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE 570
Query: 493 PTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLD 552
PTRI L P ++TVGE+ + C A D +LD+TF W+ G IDF +E H++
Sbjct: 571 PTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQA 630
Query: 553 SNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALT 612
S+ +L+IRN L HAGRY C QT D+ S A+L+VRGPPGPPG + +E+I ++ L+
Sbjct: 631 SSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLS 690
Query: 613 WSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVA 672
WS +DNHSPIS Y +Q ++ S W+ KT P II G+ME+A AVDL PW+EYEFRVVA
Sbjct: 691 WSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVA 750
Query: 673 TNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYI 732
TN +G G+PS PS I+T+ A P AP++V G GR EL I W P+S E+ G FGYI
Sbjct: 751 TNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYI 810
Query: 733 VAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINS 792
VAF+P WK+ VT+ + +++++DE++ P T F+VKV +NNKGDGP+S + VI S
Sbjct: 811 VAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICS 870
Query: 793 AQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKI--VESYQIRYWAAHDKEEAANRVQVTS 850
A+ PS APT+V +S SEI V W+H+ E + + +++ YW ++E+ A V+
Sbjct: 871 AEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRG 930
Query: 851 QEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRY 910
E L L +T Y V A N AG GPPS + A TKK+PPSQ P + + GS+
Sbjct: 931 NESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQV 990
Query: 911 IITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSD 970
+ W+ V+ L+NES V GYKV YR +G + ++ T K VP+P G Y++EVRA+S+
Sbjct: 991 SLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSE 1050
Query: 971 GGDGVV-SQVKI 981
GGDG SQ+++
Sbjct: 1051 GGDGTASSQIRV 1062
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 878 bits (2268), Expect = 0.0
Identities = 445/983 (45%), Positives = 612/983 (62%), Gaps = 19/983 (1%)
Query: 10 LVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMN 69
LV+ S CLA ++ GPIF ++P ++P +S E KV LNC + +P P +W++N
Sbjct: 8 LVLQSFILCLA--DDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLN 65
Query: 70 NGDVDLTSD-RYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFP 128
DVD D RYS+V G+L+INNP+K +DAG Y C A+N++G + S EA L F YLD F
Sbjct: 66 GTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFK 125
Query: 129 PEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIA 188
R V V+ G+GMVLLC PP H +LSY W+ NE+P + D RRFVSQ GNLYIA
Sbjct: 126 TRTRSTVSVRRGQGMVLLCGPPPH-SGELSYAWIFNEYPSY--QDNRRFVSQETGNLYIA 182
Query: 189 NVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKD-VYALMGQN 247
VE SD GNY+C V++ V PLI + Y I VQF + V G
Sbjct: 183 KVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGAT 242
Query: 248 VTLECFALGNPVPDIRWRKVL-EPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRG 306
V LECFALGNPVP I WR+ +P+ A S +L+I N Q ED G+YEC AEN RG
Sbjct: 243 VKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRG 302
Query: 307 KDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNG--------Y 358
K+ + ++ A P W++ IND V + +++W C A G+P PT +WLKNG
Sbjct: 303 KNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRI 362
Query: 359 AYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKG 418
+G L + V +AGMYQC+AEN +G I++NAEL ++A+ P F +K+ L G
Sbjct: 363 QIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVG 422
Query: 419 GRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENN 478
G V+IECKPKA+PKP ++W KG + L + RI I EDG+L I N+T++D G YTC A N+
Sbjct: 423 GEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNH 482
Query: 479 RGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDF 538
G A+STG LV+ DPTR+++ P + D+TVGE+ + C + D +LD+ F WSFNG++IDF
Sbjct: 483 FGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDF 542
Query: 539 NKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGG 598
+++ H++R DS G+L+IRN QLKHAG+Y C QT VD SA+ADL+VRGPPGPP
Sbjct: 543 DRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEA 602
Query: 599 LRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAV 658
+ I++I T+ L+W G DNHSPI+ Y IQ +T S W+ T P +I+G A V
Sbjct: 603 VTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVV 662
Query: 659 DLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAP 718
L PW+EYEFR VA N +G GEPS PS + +T+ A P V P++V GGGG EL ITW
Sbjct: 663 GLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWET 722
Query: 719 LSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNN 778
+ E G FGY+VAF+P+ W + + D RYV ++E++ P + F+VKV FNN
Sbjct: 723 VPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNN 782
Query: 779 KGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEK---IVESYQIRYWA 835
KG+GP+S V+ SA++ P++ P + + LS+++I V W LEK ++ Y+++YW
Sbjct: 783 KGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWR 842
Query: 836 AHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPS 895
DKEE A +++ + S ++ NL Y + V A NSAG GP S + T+K PPS
Sbjct: 843 HEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPS 902
Query: 896 QPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPI 955
QPP I S S+ I+ WD V AL NES V GYKVLYR + Q + T+K S+E+ +
Sbjct: 903 QPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSL 962
Query: 956 PRDGEYVVEVRAHSDGGDGVVSQ 978
P D +Y++E++ SDGGDG S+
Sbjct: 963 PFDEDYIIEIKPFSDGGDGSSSE 985
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 877 bits (2266), Expect = 0.0
Identities = 439/984 (44%), Positives = 620/984 (63%), Gaps = 19/984 (1%)
Query: 10 LVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMN 69
L+++S CL E GP+F ++P N+I+P S + K++L+C AR +P P Y+W++N
Sbjct: 8 LILLSFIGCLG--GELLLQGPVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLN 65
Query: 70 NGDVDLTSD-RYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFP 128
D+D++ + RY + GGNLV+ NP++ D G Y C A+N+ G + S EA L F YL+ F
Sbjct: 66 GSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFK 125
Query: 129 PEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIA 188
+ R V V+EG+G+VLLC PP H +LSY W+ NE+P F+ D RRFVSQ G+LYI+
Sbjct: 126 TKMRSTVSVREGQGVVLLCGPPPH-SGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYIS 184
Query: 189 NVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVY-ALMGQN 247
VE SD GNY+C V+S V PL+ + Y I VQF + A G
Sbjct: 185 KVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGST 244
Query: 248 VTLECFALGNPVPDIRWRKVLE-PMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRG 306
V LECFALGNP+P I WR+ P S ++ VL+I N Q ED G YEC AEN RG
Sbjct: 245 VKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRG 304
Query: 307 KDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAY------ 360
K+ + R+ A P WV+ I D E+ + LYW C A+GKP P+ RWLKNG A
Sbjct: 305 KNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERT 364
Query: 361 --HKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKG 418
G L + +++ ++GM+QCIAEN +G +Y++AELK++A AP F NPMKK + G
Sbjct: 365 QIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVG 424
Query: 419 GRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENN 478
V ++CKP+A+P+ SW KG + RI + DG L+I N+T+ D G YTC AEN
Sbjct: 425 SLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAENQ 484
Query: 479 RGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDF 538
GKAN T LV+T+PTRI LAP N D++VGE+ + C DP LD+ F W FNG + DF
Sbjct: 485 FGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADF 544
Query: 539 NKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGG 598
K+ H+++ S+G+L+IRN QLKH+G+Y C QT VD+ S++ADL+VRG PGPP
Sbjct: 545 KKDGSHFEK-VGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSPGPPEN 603
Query: 599 LRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAV 658
+++++I T+ L+W G DNHSP+ Y+IQ +T S W+ T P +I+G A V
Sbjct: 604 VKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHTATVV 663
Query: 659 DLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAP 718
+L PW+EYEFRVVA+N +G GEPS+PS +++T+ A P V PS+V GGGG EL ITW P
Sbjct: 664 ELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRSELVITWDP 723
Query: 719 LSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNN 778
+ E G FGY+VAF+P W + VT+PDT RYV ++E++ P + ++VKV +NN
Sbjct: 724 VPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNN 783
Query: 779 KGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKI----VESYQIRYW 834
KG+GP+S V + SA++ P+ AP++V LSSSEI V W + K+ + Y++RYW
Sbjct: 784 KGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYW 843
Query: 835 AAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPP 894
KEE++++++V E SARL L + Y+ V A NSAG GP S + TKK PP
Sbjct: 844 NGGGKEESSSKMKVAGNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKKTPP 903
Query: 895 SQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVP 954
SQPP + + ++ ++ W+ V A+ NES VTGYKV YR Q++ ++ +T+K S E+
Sbjct: 904 SQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQNNVQVLNTNKTSAELV 963
Query: 955 IPRDGEYVVEVRAHSDGGDGVVSQ 978
+P +Y++EV+A +DGGDG S+
Sbjct: 964 LPIKEDYIIEVKATTDGGDGTSSE 987
Score = 76.3 bits (186), Expect = 1e-13
Identities = 73/285 (25%), Positives = 126/285 (44%), Gaps = 30/285 (10%)
Query: 656 RAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTIT 715
R ++P+ YE +V N G G P P + + P VAPS V + E+ ++
Sbjct: 764 RNESIVPYSPYEVKVGVYNNKGEG-PFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVS 822
Query: 716 WAPLSREYHYGNNFGYIVAFKPFDGEEWK--KVTVTNPDTGRYVHKDETMSPSTAFQVKV 773
W + + G+ GY V + G+E K+ V +T + + + A+ V
Sbjct: 823 WNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNETSARLRG---LKSNLAYYTAV 879
Query: 774 KAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVL----EKIVESY 829
+A+N+ G GP+S + + + PS+ P V V + +++ ++WE V E V Y
Sbjct: 880 RAYNSAGAGPFSATVNVTTKKTPPSQPPGNV-VWNATDTKVLLNWEQVKAMENESEVTGY 938
Query: 830 QIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQ-YFIEVGACNSAGCGPPSDMIEAF 888
++ Y + + N VQV + ++ E +LP + Y IEV A G G S+ I
Sbjct: 939 KVFY-----RTSSQNNVQVLNTNKTSA-ELVLPIKEDYIIEVKATTDGGDGTSSEQIRI- 991
Query: 889 TKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLY 933
PRI S GS I+ +V +S+ + + ++Y
Sbjct: 992 ---------PRITSMDARGSTSAIS--NVHPMSSYMPIVLFLIVY 1025
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 821 bits (2120), Expect = 0.0
Identities = 421/985 (42%), Positives = 599/985 (60%), Gaps = 18/985 (1%)
Query: 30 PIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLT-SDRYSMVGGNLV 88
PIF ++P + I+P + + +V LNC A P P Y+W+ N D+D T S Y + GG+L
Sbjct: 26 PIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLA 85
Query: 89 INNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCD 148
IN+P +D G+Y CLA+N G + S +A L F Y++ F + R V V+EG+G+VLLC
Sbjct: 86 INSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCG 145
Query: 149 PPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSIT 208
PP HF DLSY W N+ P+++ D RRFVSQ GNLYIA VE SD GNY+CF+++
Sbjct: 146 PPPHF-GDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQ 204
Query: 209 KSVFSKFIPLIPIPERTTKPYPADIVVQFKD-VYALMGQNVTLECFALGNPVPDIRWRKV 267
+SV PL+ + Y I V+F + + A +V LECFALGNPVPDI WR++
Sbjct: 205 RSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRL 264
Query: 268 L-EPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHI 326
P+P + S S A+L+I N Q EDEG YEC A N+RG++ + ++ A PEW + I
Sbjct: 265 DGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKI 324
Query: 327 NDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYH--------KGELRLYDVTFENAGMY 378
+T + I +L W C A+GKP P WLKNG + G L + + ++G+Y
Sbjct: 325 QNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEERIQIENGTLIITMLNVSDSGVY 384
Query: 379 QCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWS 438
QC AEN Y IYANAEL++LA AP F +P+KKK GG ++I CKP A P+ SW
Sbjct: 385 QCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWK 444
Query: 439 KGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIIL 498
+GTE L S RI + EDGSL+I NITR+D G YTC A N G A +TG+L++ + T I +
Sbjct: 445 RGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITV 504
Query: 499 APINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELL 558
P D+TVGE+ + C S DP++++ FVW FNG VID K H++R +S G+L+
Sbjct: 505 PPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFER-IGGESVGDLM 563
Query: 559 IRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSD 618
IRN QL H+G+Y CT QT +++ SA AD++VRGPPGPP +++EDI +T+ L+W G D
Sbjct: 564 IRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPD 623
Query: 619 NHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGR 678
N+SPI +TIQT+T S W+ T P I+ G A V L PW+EYEFRVVA N++G
Sbjct: 624 NNSPIQIFTIQTRTPFSVGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGI 683
Query: 679 GEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPF 738
GEPS PS ++T + P VAP ++ GGGG EL ITW + E G FGYI+ F+P
Sbjct: 684 GEPSEPSELLRTKASVPVVAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPV 743
Query: 739 DGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPS 798
W K V++ ++ R+V+++E++ P + F+VKV +NN+G+G S V ++ S +D P
Sbjct: 744 GSTTWSKEKVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQ 803
Query: 799 EAPTEVGVKVLSSSEISVHWEHVL----EKIVESYQIRYWAAHDKEEAANRVQVTSQEYS 854
AP ++ S+SE+ V W + V Y++ YW KE +++V+ +
Sbjct: 804 LAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTT 863
Query: 855 ARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITW 914
+ L +T YF V A N+AG GP S + TKK+PPSQPP I+ + S+ + W
Sbjct: 864 KNITGLKANTIYFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNW 923
Query: 915 DHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDG 974
+HV + NES V GYK+LYR + Q + T+ S E+ +P + +Y++E+R SDGGDG
Sbjct: 924 EHVKTMENESEVLGYKILYRQNRQSKTHILETNNTSAELLVPFEEDYLIEIRTVSDGGDG 983
Query: 975 VVS-QVKISGAPTLSPSLLGLLLPA 998
S +++I +LS + L P+
Sbjct: 984 SSSEEIRIPKMSSLSSRGIQFLEPS 1008
>gi|28373126 contactin 4 isoform c precursor [Homo sapiens]
Length = 698
Score = 617 bits (1590), Expect = e-176
Identities = 296/654 (45%), Positives = 417/654 (63%), Gaps = 11/654 (1%)
Query: 336 DLYWPCVATGKPIPTIRWLKNG--------YAYHKGELRLYDVTFENAGMYQCIAENTYG 387
+++W C A G+P PT +WLKNG +G L + V +AGMYQC+AEN +G
Sbjct: 4 NVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHG 63
Query: 388 AIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNS 447
I++NAEL ++A+ P F +K+ L GG V+IECKPKA+PKP ++W KG + L +
Sbjct: 64 VIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKEN 123
Query: 448 SRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITV 507
RI I EDG+L I N+T++D G YTC A N+ G A+STG LV+ DPTR+++ P + D+TV
Sbjct: 124 ERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTV 183
Query: 508 GENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHA 567
GE+ + C + D +LD+ F WSFNG++IDF+++ H++R DS G+L+IRN QLKHA
Sbjct: 184 GESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHA 243
Query: 568 GRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYT 627
G+Y C QT VD SA+ADL+VRGPPGPP + I++I T+ L+W G DNHSPI+ Y
Sbjct: 244 GKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYV 303
Query: 628 IQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNR 687
IQ +T S W+ T P +I+G A V L PW+EYEFR VA N +G GEPS PS +
Sbjct: 304 IQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEK 363
Query: 688 IKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVT 747
+T+ A P V P++V GGGG EL ITW + E G FGY+VAF+P+ W
Sbjct: 364 RRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTV 423
Query: 748 VTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVK 807
+ + D RYV ++E++ P + F+VKV FNNKG+GP+S V+ SA++ P++ P + +
Sbjct: 424 LASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFAR 483
Query: 808 VLSSSEISVHWEHVLEK---IVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDT 864
LS+++I V W LEK ++ Y+++YW DKEE A +++ + S ++ NL
Sbjct: 484 SLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSV 543
Query: 865 QYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNES 924
Y + V A NSAG GP S + T+K PPSQPP I S S+ I+ WD V AL NES
Sbjct: 544 LYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNES 603
Query: 925 TVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQ 978
V GYKVLYR + Q + T+K S+E+ +P D +Y++E++ SDGGDG S+
Sbjct: 604 EVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSE 657
Score = 79.0 bits (193), Expect = 2e-14
Identities = 71/275 (25%), Positives = 108/275 (39%), Gaps = 32/275 (11%)
Query: 244 MGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAEN 303
M +NV EC A G P P +W K EP+ + I L I + L D G+Y+C AEN
Sbjct: 1 MEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAEN 60
Query: 304 IRGKDKHQARIYVQAF-PEWVEHI--NDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAY 360
G A + V A P++ + T V +G ++ C P P W K
Sbjct: 61 KHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL 120
Query: 361 HK---------GELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKK 411
+ G LR+ +VT +AG Y CIA N +G A++ ++ PT M P
Sbjct: 121 KENERITISEDGNLRIINVTKSDAGSYTCIATNHFGT--ASSTGNLVVKDPTRVMVPPSS 178
Query: 412 KILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWED-------------GSL 458
+ G +++ C+ ++ W N I D G L
Sbjct: 179 MDVTV-GESIVLPCQVTHDHSLDIVFT----WSFNGHLIDFDRDGDHFERVGGQDSAGDL 233
Query: 459 EINNITRNDGGIYTCFAENNRGKANSTGTLVITDP 493
I NI G Y C + + + ++ L++ P
Sbjct: 234 MIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGP 268
Score = 69.3 bits (168), Expect = 2e-11
Identities = 87/307 (28%), Positives = 126/307 (41%), Gaps = 31/307 (10%)
Query: 46 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 105
+E V C+A P P YKW + NG+ LT DR + G L I + DAG+Y CLA
Sbjct: 1 MEENVFWECKANGRPKPTYKW-LKNGEPLLTRDRIQIEQGTLNITIVNLS-DAGMYQCLA 58
Query: 106 SNNYGMVRSTEATLSFGYLDP-FPPEERPEVR-VKEGKGMVLLCDPPYHFPDDLSYRWLL 163
N +G++ S A LS + P F V VK G +V+ C P P + Y W
Sbjct: 59 ENKHGVIFSN-AELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKAS-PKPV-YTWKK 115
Query: 164 NEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPE 223
I + R +GNL I NV SD G+Y+C ++ T S + + P
Sbjct: 116 GRD---ILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLV--VKDPT 170
Query: 224 RTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDI----RWRKVLEPMPSTAEI-- 277
R P P+ + V +G+++ L C + DI + L +
Sbjct: 171 RVMVP-PSSMDV-------TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFE 222
Query: 278 ----STSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEV-D 332
S L I NIQL+ G Y C + + A + V+ P E + E+ D
Sbjct: 223 RVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITD 282
Query: 333 IGSDLYW 339
+ L W
Sbjct: 283 TTAQLSW 289
>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
Length = 1174
Score = 365 bits (937), Expect = e-100
Identities = 281/926 (30%), Positives = 412/926 (44%), Gaps = 87/926 (9%)
Query: 50 VSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMV--GGNLVIN-----NPDKQKDAGIY 101
+ + C A+ +P P + W N+ ++ D R SM G LVI+ P++ + G Y
Sbjct: 53 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--GEY 110
Query: 102 YCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRW 161
C A N +G S L +P E V V+EG + L C+PP P + + W
Sbjct: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIF-W 169
Query: 162 LLNEFPVFITMDKRRFVSQ-TNGNLYIANVEASD-KGNYSCFVSSPSITKSVFSKFIPLI 219
+ + IT DKR VSQ NG+LY +NV D + +YSC T ++ K
Sbjct: 170 MSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARF-HFTHTIQQK--NPF 223
Query: 220 PIPERTTKPYPADIVVQFKDVYA-----------------------LMGQNVTLECFALG 256
+ T PY + D+Y+ L G ++ LEC A G
Sbjct: 224 TLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 283
Query: 257 NPVPDIRWRKVLEPMPS-TAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIY 315
P PDI W K +PS A+ L+I N+ ED G Y C A N G +H +
Sbjct: 284 VPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 343
Query: 316 VQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------GEL 365
V+A P W++ + + G D C A G P PT++W+ NG G+
Sbjct: 344 VKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 403
Query: 366 RLY-DVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIE 424
++ D + +YQC N +G + ANA + +L + P ++P + I R ++
Sbjct: 404 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLD 462
Query: 425 CKPKAAPKPKFSWSK-GTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKAN 483
C +P P W K G ++ ++E+GSLEI I + D GIYTC A N GKA
Sbjct: 463 CPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAE 522
Query: 484 STGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENI 543
+ L + DPTRI P + G ++C DP+L LT W +
Sbjct: 523 NQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEP 574
Query: 544 HYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIED 603
Y N M + L I + G YTC A T +D A A L V G P P L + D
Sbjct: 575 LYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTD 634
Query: 604 IRATSVALTWSRGSDNHSPISKYTIQTK--TILSDDWKDAKTDPPIIEGNMEAARAVDLI 661
+ SV LTW G N+SPI+ Y +Q + W D P G++ +A + L
Sbjct: 635 LAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP----GSVNSA-VLRLS 689
Query: 662 PWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSR 721
P++ Y+FRV+A N +G PS+PS R +T GA P P DV G G R + ITW P++
Sbjct: 690 PYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNA 749
Query: 722 EYHYGNNFGYIVAFKPFDGEE-WKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKG 780
+G N YIV ++ + E W VTV RYV + ++++V+A N+ G
Sbjct: 750 TSAFGPNLRYIVKWRRRETREAWNNVTVWG---SRYVVGQTPV--YVPYEIRVQAENDFG 804
Query: 781 DGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKE 840
GP + S +D P APTEV V+V++S+ IS+ W V V+ Y A + +E
Sbjct: 805 KGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRE 864
Query: 841 EAANRVQVTSQEYSAR----------LENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTK 890
+ + SQ+ + L P + Y +E+ N G GP S+ E T
Sbjct: 865 SSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP 924
Query: 891 KAPPSQPPRIISSVRSGSRYIITWDH 916
+ PS P R + + WDH
Sbjct: 925 EGVPSAPRRFRVRQPNLETINLEWDH 950
Score = 68.2 bits (165), Expect = 4e-11
Identities = 92/403 (22%), Positives = 143/403 (35%), Gaps = 57/403 (14%)
Query: 219 IPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPS 273
I IP T+P P KD N+ +EC A GNP P W + + P
Sbjct: 25 IEIPMDLTQP-PTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR 83
Query: 274 TAEISTSGAVLKIFNI---QLEDEGIYECEAENIRGKD-KHQARIYVQAFPEW-VEHIND 328
+ SG ++ F E EG Y+C A N G ++ R+ V P W E+++
Sbjct: 84 VSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 143
Query: 329 TEVDIGSDLYWPC-VATGKPIPTIRWL----------KNGYAYHKGELRLYDVTFENAGM 377
V G+ L C G P P I W+ K H G+L +V ++
Sbjct: 144 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT 203
Query: 378 -YQCIAENTYGAIYANAE---LKILALAP-----------------TFEMNP-------M 409
Y C A + LK+L P E P
Sbjct: 204 DYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGT 263
Query: 410 KKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGG 469
+ +G +++EC P P +W K L + + +L I N++ D G
Sbjct: 264 ASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSG 323
Query: 470 IYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVW 529
Y C A N G T ++ + + P N + GE+ + C A+ +P T W
Sbjct: 324 EYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQW 381
Query: 530 SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTC 572
NG + N + + + ++ R+ Q+ Y C
Sbjct: 382 MVNGEPLQSAPPNPNRE-----VAGDTIIFRDTQISSRAVYQC 419
Score = 53.9 bits (128), Expect = 7e-07
Identities = 43/180 (23%), Positives = 80/180 (44%), Gaps = 9/180 (5%)
Query: 46 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 105
L + L+C SP P +W N +L Y + + +++D GIY C+A
Sbjct: 455 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 514
Query: 106 SNNYGMVRSTEATLSFGYLDPFPPEERPEVRV-KEGKGMVLLCDPPYHFPDDLSYRWLLN 164
+N G E + DP PE +V + G + L C + L+ WL +
Sbjct: 515 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 571
Query: 165 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPER 224
+ P++I + + + +L I V D+G+Y+C V+S + + + ++ ++ P+R
Sbjct: 572 DEPLYI----GNRMKKEDDSLTIFGVAERDQGSYTC-VASTELDQDLAKAYLTVLGRPDR 626
Score = 36.6 bits (83), Expect = 0.12
Identities = 42/214 (19%), Positives = 77/214 (35%), Gaps = 13/214 (6%)
Query: 592 PPGPPGGLRIEDIRATSVALTWSRGSDNH-----SPISKYTIQTKTILSDDWKDAKTDPP 646
P P +++ + +T+++L W+R + Y + ++L + W K
Sbjct: 821 PRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQA 880
Query: 647 IIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGG 706
G+ L P+ Y+ +V N G G P + T P+ AP
Sbjct: 881 SFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDG-PRSETKEFTTPEGVPS-APRRFRVRQ 938
Query: 707 GRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPS 766
+ + W E+ G GY + + F+G + K V N + + P
Sbjct: 939 PNLETINLEWD--HPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPV 996
Query: 767 TAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEA 800
+ ++ + A G G AV + P+EA
Sbjct: 997 SRYRFTLSARTQVGSGE----AVTEESPAPPNEA 1026
>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
Length = 1169
Score = 365 bits (937), Expect = e-100
Identities = 281/926 (30%), Positives = 412/926 (44%), Gaps = 87/926 (9%)
Query: 50 VSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMV--GGNLVIN-----NPDKQKDAGIY 101
+ + C A+ +P P + W N+ ++ D R SM G LVI+ P++ + G Y
Sbjct: 53 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--GEY 110
Query: 102 YCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRW 161
C A N +G S L +P E V V+EG + L C+PP P + + W
Sbjct: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIF-W 169
Query: 162 LLNEFPVFITMDKRRFVSQ-TNGNLYIANVEASD-KGNYSCFVSSPSITKSVFSKFIPLI 219
+ + IT DKR VSQ NG+LY +NV D + +YSC T ++ K
Sbjct: 170 MSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARF-HFTHTIQQK--NPF 223
Query: 220 PIPERTTKPYPADIVVQFKDVYA-----------------------LMGQNVTLECFALG 256
+ T PY + D+Y+ L G ++ LEC A G
Sbjct: 224 TLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 283
Query: 257 NPVPDIRWRKVLEPMPS-TAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIY 315
P PDI W K +PS A+ L+I N+ ED G Y C A N G +H +
Sbjct: 284 VPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 343
Query: 316 VQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------GEL 365
V+A P W++ + + G D C A G P PT++W+ NG G+
Sbjct: 344 VKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 403
Query: 366 RLY-DVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIE 424
++ D + +YQC N +G + ANA + +L + P ++P + I R ++
Sbjct: 404 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLD 462
Query: 425 CKPKAAPKPKFSWSK-GTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKAN 483
C +P P W K G ++ ++E+GSLEI I + D GIYTC A N GKA
Sbjct: 463 CPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAE 522
Query: 484 STGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENI 543
+ L + DPTRI P + G ++C DP+L LT W +
Sbjct: 523 NQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEP 574
Query: 544 HYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIED 603
Y N M + L I + G YTC A T +D A A L V G P P L + D
Sbjct: 575 LYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTD 634
Query: 604 IRATSVALTWSRGSDNHSPISKYTIQTK--TILSDDWKDAKTDPPIIEGNMEAARAVDLI 661
+ SV LTW G N+SPI+ Y +Q + W D P G++ +A + L
Sbjct: 635 LAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP----GSVNSA-VLRLS 689
Query: 662 PWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSR 721
P++ Y+FRV+A N +G PS+PS R +T GA P P DV G G R + ITW P++
Sbjct: 690 PYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNA 749
Query: 722 EYHYGNNFGYIVAFKPFDGEE-WKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKG 780
+G N YIV ++ + E W VTV RYV + ++++V+A N+ G
Sbjct: 750 TSAFGPNLRYIVKWRRRETREAWNNVTVWG---SRYVVGQTPV--YVPYEIRVQAENDFG 804
Query: 781 DGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKE 840
GP + S +D P APTEV V+V++S+ IS+ W V V+ Y A + +E
Sbjct: 805 KGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRE 864
Query: 841 EAANRVQVTSQEYSAR----------LENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTK 890
+ + SQ+ + L P + Y +E+ N G GP S+ E T
Sbjct: 865 SSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP 924
Query: 891 KAPPSQPPRIISSVRSGSRYIITWDH 916
+ PS P R + + WDH
Sbjct: 925 EGVPSAPRRFRVRQPNLETINLEWDH 950
Score = 68.2 bits (165), Expect = 4e-11
Identities = 92/403 (22%), Positives = 143/403 (35%), Gaps = 57/403 (14%)
Query: 219 IPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPS 273
I IP T+P P KD N+ +EC A GNP P W + + P
Sbjct: 25 IEIPMDLTQP-PTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR 83
Query: 274 TAEISTSGAVLKIFNI---QLEDEGIYECEAENIRGKD-KHQARIYVQAFPEW-VEHIND 328
+ SG ++ F E EG Y+C A N G ++ R+ V P W E+++
Sbjct: 84 VSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 143
Query: 329 TEVDIGSDLYWPC-VATGKPIPTIRWL----------KNGYAYHKGELRLYDVTFENAGM 377
V G+ L C G P P I W+ K H G+L +V ++
Sbjct: 144 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT 203
Query: 378 -YQCIAENTYGAIYANAE---LKILALAP-----------------TFEMNP-------M 409
Y C A + LK+L P E P
Sbjct: 204 DYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGT 263
Query: 410 KKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGG 469
+ +G +++EC P P +W K L + + +L I N++ D G
Sbjct: 264 ASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSG 323
Query: 470 IYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVW 529
Y C A N G T ++ + + P N + GE+ + C A+ +P T W
Sbjct: 324 EYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQW 381
Query: 530 SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTC 572
NG + N + + + ++ R+ Q+ Y C
Sbjct: 382 MVNGEPLQSAPPNPNRE-----VAGDTIIFRDTQISSRAVYQC 419
Score = 53.9 bits (128), Expect = 7e-07
Identities = 43/180 (23%), Positives = 80/180 (44%), Gaps = 9/180 (5%)
Query: 46 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 105
L + L+C SP P +W N +L Y + + +++D GIY C+A
Sbjct: 455 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 514
Query: 106 SNNYGMVRSTEATLSFGYLDPFPPEERPEVRV-KEGKGMVLLCDPPYHFPDDLSYRWLLN 164
+N G E + DP PE +V + G + L C + L+ WL +
Sbjct: 515 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 571
Query: 165 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPER 224
+ P++I + + + +L I V D+G+Y+C V+S + + + ++ ++ P+R
Sbjct: 572 DEPLYI----GNRMKKEDDSLTIFGVAERDQGSYTC-VASTELDQDLAKAYLTVLGRPDR 626
Score = 37.4 bits (85), Expect = 0.072
Identities = 43/216 (19%), Positives = 78/216 (36%), Gaps = 13/216 (6%)
Query: 592 PPGPPGGLRIEDIRATSVALTWSRGSDNH-----SPISKYTIQTKTILSDDWKDAKTDPP 646
P P +++ + +T+++L W+R + Y + ++L + W K
Sbjct: 821 PRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQA 880
Query: 647 IIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGG 706
G+ L P+ Y+ +V N G G P + T P+ AP
Sbjct: 881 SFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDG-PRSETKEFTTPEGVPS-APRRFRVRQ 938
Query: 707 GRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPS 766
+ + W E+ G GY + + F+G + K V N + + P
Sbjct: 939 PNLETINLEWD--HPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPV 996
Query: 767 TAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPT 802
+ ++ + A G G AV + P+EA T
Sbjct: 997 SRYRFTLSARTQVGSGE----AVTEESPAPPNEAYT 1028
>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
Length = 1189
Score = 357 bits (915), Expect = 4e-98
Identities = 281/941 (29%), Positives = 413/941 (43%), Gaps = 102/941 (10%)
Query: 50 VSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMV--GGNLVIN-----NPDKQKDAGIY 101
+ + C A+ +P P + W N+ ++ D R SM G LVI+ P++ + G Y
Sbjct: 53 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--GEY 110
Query: 102 YCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRW 161
C A N +G S L +P E V V+EG + L C+PP P + + W
Sbjct: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIF-W 169
Query: 162 LLNEFPVFITMDKRRFVSQ-TNGNLYIANVEASD-KGNYSCFVSSPSITKSVFSKFIPLI 219
+ + IT DKR VSQ NG+LY +NV D + +YSC T ++ K
Sbjct: 170 MSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARF-HFTHTIQQK--NPF 223
Query: 220 PIPERTTKPYPADIVVQFKDVYA-----------------------LMGQNVTLECFALG 256
+ T PY + D+Y+ L G ++ LEC A G
Sbjct: 224 TLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 283
Query: 257 NPVPDIRWRKVLEPMPS-TAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIY 315
P PDI W K +PS A+ L+I N+ ED G Y C A N G +H +
Sbjct: 284 VPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 343
Query: 316 VQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------GEL 365
V+A P W++ + + G D C A G P PT++W+ NG G+
Sbjct: 344 VKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 403
Query: 366 RLY-DVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIE 424
++ D + +YQC N +G + ANA + +L + P ++P + I R ++
Sbjct: 404 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLD 462
Query: 425 CKPKAAPKPKFSWSK-GTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKAN 483
C +P P W K G ++ ++E+GSLEI I + D GIYTC A N GKA
Sbjct: 463 CPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAE 522
Query: 484 STGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENI 543
+ L + DPTRI P + G ++C DP+L LT W +
Sbjct: 523 NQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEP 574
Query: 544 HYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVV-------------- 589
Y N M + L I + G YTC A T +D A A L V
Sbjct: 575 LYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAAL 634
Query: 590 -RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTK--TILSDDWKDAKTDPP 646
+G P P L + D+ SV LTW G N+SPI+ Y +Q + W D P
Sbjct: 635 PKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP- 693
Query: 647 IIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGG 706
G++ +A + L P++ Y+FRV+A N +G PS+PS R +T GA P P DV G G
Sbjct: 694 ---GSVNSA-VLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEG 749
Query: 707 GRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEE-WKKVTVTNPDTGRYVHKDETMSP 765
R + ITW P++ +G N YIV ++ + E W VTV RYV +
Sbjct: 750 TRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWG---SRYVVGQTPV-- 804
Query: 766 STAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKI 825
++++V+A N+ G GP + S +D P APTEV V+V++S+ IS+ W V
Sbjct: 805 YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDT 864
Query: 826 VESYQIRYWAAHDKEEAANRVQVTSQEYSAR----------LENLLPDTQYFIEVGACNS 875
V+ Y A + +E + + SQ+ + L P + Y +E+ N
Sbjct: 865 VQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNG 924
Query: 876 AGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDH 916
G GP S+ E T + PS P R + + WDH
Sbjct: 925 RGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDH 965
Score = 68.2 bits (165), Expect = 4e-11
Identities = 92/403 (22%), Positives = 143/403 (35%), Gaps = 57/403 (14%)
Query: 219 IPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPS 273
I IP T+P P KD N+ +EC A GNP P W + + P
Sbjct: 25 IEIPMDLTQP-PTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR 83
Query: 274 TAEISTSGAVLKIFNI---QLEDEGIYECEAENIRGKD-KHQARIYVQAFPEW-VEHIND 328
+ SG ++ F E EG Y+C A N G ++ R+ V P W E+++
Sbjct: 84 VSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 143
Query: 329 TEVDIGSDLYWPC-VATGKPIPTIRWL----------KNGYAYHKGELRLYDVTFENAGM 377
V G+ L C G P P I W+ K H G+L +V ++
Sbjct: 144 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT 203
Query: 378 -YQCIAENTYGAIYANAE---LKILALAP-----------------TFEMNP-------M 409
Y C A + LK+L P E P
Sbjct: 204 DYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGT 263
Query: 410 KKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGG 469
+ +G +++EC P P +W K L + + +L I N++ D G
Sbjct: 264 ASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSG 323
Query: 470 IYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVW 529
Y C A N G T ++ + + P N + GE+ + C A+ +P T W
Sbjct: 324 EYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQW 381
Query: 530 SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTC 572
NG + N + + + ++ R+ Q+ Y C
Sbjct: 382 MVNGEPLQSAPPNPNRE-----VAGDTIIFRDTQISSRAVYQC 419
Score = 50.8 bits (120), Expect = 6e-06
Identities = 40/160 (25%), Positives = 69/160 (43%), Gaps = 8/160 (5%)
Query: 46 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 105
L + L+C SP P +W N +L Y + + +++D GIY C+A
Sbjct: 455 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 514
Query: 106 SNNYGMVRSTEATLSFGYLDPFPPEERPEVRV-KEGKGMVLLCDPPYHFPDDLSYRWLLN 164
+N G E + DP PE +V + G + L C + L+ WL +
Sbjct: 515 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 571
Query: 165 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 204
+ P++I + + + +L I V D+G+Y+C S+
Sbjct: 572 DEPLYI----GNRMKKEDDSLTIFGVAERDQGSYTCVAST 607
Score = 36.6 bits (83), Expect = 0.12
Identities = 42/214 (19%), Positives = 77/214 (35%), Gaps = 13/214 (6%)
Query: 592 PPGPPGGLRIEDIRATSVALTWSRGSDNH-----SPISKYTIQTKTILSDDWKDAKTDPP 646
P P +++ + +T+++L W+R + Y + ++L + W K
Sbjct: 836 PRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQA 895
Query: 647 IIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGG 706
G+ L P+ Y+ +V N G G P + T P+ AP
Sbjct: 896 SFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDG-PRSETKEFTTPEGVPS-APRRFRVRQ 953
Query: 707 GRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPS 766
+ + W E+ G GY + + F+G + K V N + + P
Sbjct: 954 PNLETINLEWD--HPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPV 1011
Query: 767 TAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEA 800
+ ++ + A G G AV + P+EA
Sbjct: 1012 SRYRFTLSARTQVGSGE----AVTEESPAPPNEA 1041
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 345 bits (885), Expect = 1e-94
Identities = 281/979 (28%), Positives = 426/979 (43%), Gaps = 85/979 (8%)
Query: 10 LVIISITTCLAVSEEDKGFG----PIFEEQPIN--TIYPEESLEGKVSLNCRARASPFPV 63
L++ S + + EE +G P+ EQ ++P + +SL C A P
Sbjct: 11 LLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDD----ISLKCEASGKPEVQ 66
Query: 64 YKWRMNN------GDVDLTSDRYSMVGGNLVINNPDK--QKDAGIYYCLASNNYGMVRST 115
++W + ++ +T + G + N Q+ GIY C ASN G S
Sbjct: 67 FRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSH 126
Query: 116 EATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKR 175
E L +P E V V+EG+ +VL C+PP + L W+ N + I D+R
Sbjct: 127 EIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPS-AEPLRIYWM-NSKILHIKQDER 184
Query: 176 RFVSQTNGNLYIANVEASDK-GNYSCFVSSPSITKSVFSKFIPLIPIPERTT-------- 226
+ Q NGNLY ANV SD +Y C P T+++ K PI R
Sbjct: 185 VTMGQ-NGNLYFANVLTSDNHSDYICHAHFPG-TRTIIQKE----PIDLRVKATNSMIDR 238
Query: 227 KPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPST-AEISTSGAVLK 285
KP + AL GQ + LEC A G P P I+W + PMP+ L+
Sbjct: 239 KPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQ 298
Query: 286 IFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATG 345
+ + ED+G Y C AEN G +H + V+A P W+ G C G
Sbjct: 299 LLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQG 358
Query: 346 KPIPTIRWLKNG-----------YAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAE 394
+P P + W NG Y +G L L +V + + QC A N +G + ANA
Sbjct: 359 RPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAY 418
Query: 395 LKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSW--SKGTEWLVNSSRILI 452
+ ++ L P + + +A +G + CK AP P W GT ++ R
Sbjct: 419 IYVVQL-PAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTT-VLQDERFFP 476
Query: 453 WEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENAT 512
+ +G+L I ++ ND G Y C A N++ L + D T+I P + G T
Sbjct: 477 YANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVT 536
Query: 513 MQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTC 572
C ASFDP+L + W +G + ++ Y F+ D G L+I + G Y+C
Sbjct: 537 FTCQASFDPSLQPSITWRGDGRDLQELGDSDKY---FIED--GRLVIHSLDYSDQGNYSC 591
Query: 573 TAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRA---TSVALTWSRGSDNHSPISKYTIQ 629
A T +D + A L+V G PGP L + D+ + V ++WS D+++PI KY I+
Sbjct: 592 VASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIE 651
Query: 630 --TKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNR 687
K + + W P GN + + + L P++ Y FRV A N G GEPS S
Sbjct: 652 FEDKEMAPEKWYSLGKVP----GN-QTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSET 706
Query: 688 IKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGE-EWKKV 746
+ T AAP P DV G G + ITW PL Y V ++P W++
Sbjct: 707 VVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQ 766
Query: 747 TVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGV 806
V++P V T P +++KV+A N++G GP V + S +D P P G+
Sbjct: 767 IVSDPFL--VVSNTSTFVP---YEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGI 821
Query: 807 KVLSSSEISVHWEHV----LEKIVESYQIRYWAAHDKEEAANR------VQVTSQEYSAR 856
++L+SS + V W V ++ + Y + YW + + + R V V + S
Sbjct: 822 EILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI 881
Query: 857 LENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDH 916
L L P + Y +EV A N G GP S+ + T + P P + +S + ++ W
Sbjct: 882 LSGLRPYSSYHLEVQAFNGRGSGPASEFTFS-TPEGVPGHPEALHLECQSNTSLLLRWQ- 939
Query: 917 VVALSNESTVTGYKVLYRP 935
LS+ +TGY + Y P
Sbjct: 940 -PPLSHNGVLTGYVLSYHP 957
Score = 41.2 bits (95), Expect = 0.005
Identities = 54/217 (24%), Positives = 84/217 (38%), Gaps = 31/217 (14%)
Query: 808 VLSSSEISVHWEHVLEKI--VESYQIRYWAAHDKEEAANRV----QVTSQEYSARLENLL 861
+L+ S++ V W + +E Y I + DKE A + +V + S L+ L
Sbjct: 625 LLTQSQVRVSWSPAEDHNAPIEKYDIEF---EDKEMAPEKWYSLGKVPGNQTSTTLK-LS 680
Query: 862 PDTQYFIEVGACNSAGCGPPSDMIEAFT--KKAPPSQPPRIISSVRSGSRYIITWDHVVA 919
P Y V A N G G PS + E + AP P + + +ITW +
Sbjct: 681 PYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRW 740
Query: 920 LSNESTVTGYKVLYRPDGQH--------DGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDG 971
+ + Y+V +RP G S VP Y ++V+A +
Sbjct: 741 MDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVP------YEIKVQAVNSQ 794
Query: 972 GDGVVSQVKISGA----PTLSPSLLGL-LLPAFGILV 1003
G G QV I + P P L G+ +L + +LV
Sbjct: 795 GKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLV 831
Score = 33.5 bits (75), Expect = 1.0
Identities = 33/140 (23%), Positives = 53/140 (37%), Gaps = 7/140 (5%)
Query: 644 DPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVG 703
D ++ N + L P+ Y V A N GRG T P P +
Sbjct: 869 DHVVVPANTTSVILSGLRPYSSYHLEVQAFN--GRGSGPASEFTFSTPEGVPG-HPEALH 925
Query: 704 GGGGRNRELTITWAP-LSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDET 762
N L + W P LS H G GY++++ P D +++ D H
Sbjct: 926 LECQSNTSLLLRWQPPLS---HNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTD 982
Query: 763 MSPSTAFQVKVKAFNNKGDG 782
+SP ++ +++A +G G
Sbjct: 983 LSPHLRYRFQLQATTKEGPG 1002
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 345 bits (885), Expect = 1e-94
Identities = 281/979 (28%), Positives = 426/979 (43%), Gaps = 85/979 (8%)
Query: 10 LVIISITTCLAVSEEDKGFG----PIFEEQPIN--TIYPEESLEGKVSLNCRARASPFPV 63
L++ S + + EE +G P+ EQ ++P + +SL C A P
Sbjct: 11 LLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDD----ISLKCEASGKPEVQ 66
Query: 64 YKWRMNN------GDVDLTSDRYSMVGGNLVINNPDK--QKDAGIYYCLASNNYGMVRST 115
++W + ++ +T + G + N Q+ GIY C ASN G S
Sbjct: 67 FRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSH 126
Query: 116 EATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKR 175
E L +P E V V+EG+ +VL C+PP + L W+ N + I D+R
Sbjct: 127 EIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPS-AEPLRIYWM-NSKILHIKQDER 184
Query: 176 RFVSQTNGNLYIANVEASDK-GNYSCFVSSPSITKSVFSKFIPLIPIPERTT-------- 226
+ Q NGNLY ANV SD +Y C P T+++ K PI R
Sbjct: 185 VTMGQ-NGNLYFANVLTSDNHSDYICHAHFPG-TRTIIQKE----PIDLRVKATNSMIDR 238
Query: 227 KPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPST-AEISTSGAVLK 285
KP + AL GQ + LEC A G P P I+W + PMP+ L+
Sbjct: 239 KPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQ 298
Query: 286 IFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATG 345
+ + ED+G Y C AEN G +H + V+A P W+ G C G
Sbjct: 299 LLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQG 358
Query: 346 KPIPTIRWLKNG-----------YAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAE 394
+P P + W NG Y +G L L +V + + QC A N +G + ANA
Sbjct: 359 RPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAY 418
Query: 395 LKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSW--SKGTEWLVNSSRILI 452
+ ++ L P + + +A +G + CK AP P W GT ++ R
Sbjct: 419 IYVVQL-PAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTT-VLQDERFFP 476
Query: 453 WEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENAT 512
+ +G+L I ++ ND G Y C A N++ L + D T+I P + G T
Sbjct: 477 YANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVT 536
Query: 513 MQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTC 572
C ASFDP+L + W +G + ++ Y F+ D G L+I + G Y+C
Sbjct: 537 FTCQASFDPSLQPSITWRGDGRDLQELGDSDKY---FIED--GRLVIHSLDYSDQGNYSC 591
Query: 573 TAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRA---TSVALTWSRGSDNHSPISKYTIQ 629
A T +D + A L+V G PGP L + D+ + V ++WS D+++PI KY I+
Sbjct: 592 VASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIE 651
Query: 630 --TKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNR 687
K + + W P GN + + + L P++ Y FRV A N G GEPS S
Sbjct: 652 FEDKEMAPEKWYSLGKVP----GN-QTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSET 706
Query: 688 IKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGE-EWKKV 746
+ T AAP P DV G G + ITW PL Y V ++P W++
Sbjct: 707 VVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQ 766
Query: 747 TVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGV 806
V++P V T P +++KV+A N++G GP V + S +D P P G+
Sbjct: 767 IVSDPFL--VVSNTSTFVP---YEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGI 821
Query: 807 KVLSSSEISVHWEHV----LEKIVESYQIRYWAAHDKEEAANR------VQVTSQEYSAR 856
++L+SS + V W V ++ + Y + YW + + + R V V + S
Sbjct: 822 EILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI 881
Query: 857 LENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDH 916
L L P + Y +EV A N G GP S+ + T + P P + +S + ++ W
Sbjct: 882 LSGLRPYSSYHLEVQAFNGRGSGPASEFTFS-TPEGVPGHPEALHLECQSNTSLLLRWQ- 939
Query: 917 VVALSNESTVTGYKVLYRP 935
LS+ +TGY + Y P
Sbjct: 940 -PPLSHNGVLTGYVLSYHP 957
Score = 41.2 bits (95), Expect = 0.005
Identities = 54/217 (24%), Positives = 84/217 (38%), Gaps = 31/217 (14%)
Query: 808 VLSSSEISVHWEHVLEKI--VESYQIRYWAAHDKEEAANRV----QVTSQEYSARLENLL 861
+L+ S++ V W + +E Y I + DKE A + +V + S L+ L
Sbjct: 625 LLTQSQVRVSWSPAEDHNAPIEKYDIEF---EDKEMAPEKWYSLGKVPGNQTSTTLK-LS 680
Query: 862 PDTQYFIEVGACNSAGCGPPSDMIEAFT--KKAPPSQPPRIISSVRSGSRYIITWDHVVA 919
P Y V A N G G PS + E + AP P + + +ITW +
Sbjct: 681 PYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRW 740
Query: 920 LSNESTVTGYKVLYRPDGQH--------DGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDG 971
+ + Y+V +RP G S VP Y ++V+A +
Sbjct: 741 MDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVP------YEIKVQAVNSQ 794
Query: 972 GDGVVSQVKISGA----PTLSPSLLGL-LLPAFGILV 1003
G G QV I + P P L G+ +L + +LV
Sbjct: 795 GKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLV 831
Score = 33.5 bits (75), Expect = 1.0
Identities = 33/140 (23%), Positives = 53/140 (37%), Gaps = 7/140 (5%)
Query: 644 DPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVG 703
D ++ N + L P+ Y V A N GRG T P P +
Sbjct: 869 DHVVVPANTTSVILSGLRPYSSYHLEVQAFN--GRGSGPASEFTFSTPEGVPG-HPEALH 925
Query: 704 GGGGRNRELTITWAP-LSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDET 762
N L + W P LS H G GY++++ P D +++ D H
Sbjct: 926 LECQSNTSLLLRWQPPLS---HNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTD 982
Query: 763 MSPSTAFQVKVKAFNNKGDG 782
+SP ++ +++A +G G
Sbjct: 983 LSPHLRYRFQLQATTKEGPG 1002
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 345 bits (884), Expect = 2e-94
Identities = 279/974 (28%), Positives = 425/974 (43%), Gaps = 82/974 (8%)
Query: 12 IISITTCLAVSEEDKGFGP--IFEEQPIN-TIYPEESLEGKVSLNCRARASPFPVYKWRM 68
++ + CL + ++ P I E+ P ++P + +SL C A P ++W
Sbjct: 11 LLLCSPCLLIQIPEELMEPPVITEQSPRRLVVFPTDD----ISLKCEASGKPEVQFRWTR 66
Query: 69 NN------GDVDLTSDRYSMVGGNLVINNPDK--QKDAGIYYCLASNNYGMVRSTEATLS 120
+ ++ +T + G + N Q+ GIY C ASN G S E L
Sbjct: 67 DGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLM 126
Query: 121 FGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQ 180
+P E V V+EG+ +VL C+PP + L W+ N + I D+R + Q
Sbjct: 127 AEGAPKWPKETVKPVEVEEGESVVLPCNPPPS-AEPLRIYWM-NSKILHIKQDERVTMGQ 184
Query: 181 TNGNLYIANVEASDK-GNYSCFVSSPSITKSVFSKFIPLIPIPERTT--------KPYPA 231
NGNLY ANV SD +Y C P T+++ K PI R KP
Sbjct: 185 -NGNLYFANVLTSDNHSDYICHAHFPG-TRTIIQKE----PIDLRVKATNSMIDRKPRLL 238
Query: 232 DIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPST-AEISTSGAVLKIFNIQ 290
+ AL GQ + LEC A G P P I+W + PMP+ L++ +
Sbjct: 239 FPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVG 298
Query: 291 LEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPT 350
ED+G Y C AEN G +H + V+A P W+ G C G+P P
Sbjct: 299 EEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPE 358
Query: 351 IRWLKNG-----------YAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILA 399
+ W NG Y +G L L +V + + QC A N +G + ANA + ++
Sbjct: 359 VTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQ 418
Query: 400 LAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSW--SKGTEWLVNSSRILIWEDGS 457
L P + + +A +G + CK AP P W GT ++ R + +G+
Sbjct: 419 L-PAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTT-VLQDERFFPYANGT 476
Query: 458 LEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAA 517
L I ++ ND G Y C A N++ L + D T+I P + G T C A
Sbjct: 477 LGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQA 536
Query: 518 SFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTI 577
SFDP+L + W +G + ++ Y F+ D G L+I + G Y+C A T
Sbjct: 537 SFDPSLQPSITWRGDGRDLQELGDSDKY---FIED--GRLVIHSLDYSDQGNYSCVASTE 591
Query: 578 VDNSSASADLVVRGPPGPPGGLRIEDIRA---TSVALTWSRGSDNHSPISKYTIQ--TKT 632
+D + A L+V G PGP L + D+ + V ++WS D+++PI KY I+ K
Sbjct: 592 LDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKE 651
Query: 633 ILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDG 692
+ + W P GN + + + L P++ Y FRV A N G GEPS S + T
Sbjct: 652 MAPEKWYSLGKVP----GN-QTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPE 706
Query: 693 AAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGE-EWKKVTVTNP 751
AAP P DV G G + ITW PL Y V ++P W++ V++P
Sbjct: 707 AAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDP 766
Query: 752 DTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSS 811
V T P +++KV+A N++G GP V + S +D P P G+++L+S
Sbjct: 767 FL--VVSNTSTFVP---YEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNS 821
Query: 812 SEISVHWEHV----LEKIVESYQIRYWAAHDKEEAANR------VQVTSQEYSARLENLL 861
S + V W V ++ + Y + YW + + + R V V + S L L
Sbjct: 822 SAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLR 881
Query: 862 PDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALS 921
P + Y +EV A N G GP S+ + T + P P + +S + ++ W LS
Sbjct: 882 PYSSYHLEVQAFNGRGSGPASEFTFS-TPEGVPGHPEALHLECQSNTSLLLRWQ--PPLS 938
Query: 922 NESTVTGYKVLYRP 935
+ +TGY + Y P
Sbjct: 939 HNGVLTGYVLSYHP 952
Score = 41.2 bits (95), Expect = 0.005
Identities = 54/217 (24%), Positives = 84/217 (38%), Gaps = 31/217 (14%)
Query: 808 VLSSSEISVHWEHVLEKI--VESYQIRYWAAHDKEEAANRV----QVTSQEYSARLENLL 861
+L+ S++ V W + +E Y I + DKE A + +V + S L+ L
Sbjct: 620 LLTQSQVRVSWSPAEDHNAPIEKYDIEF---EDKEMAPEKWYSLGKVPGNQTSTTLK-LS 675
Query: 862 PDTQYFIEVGACNSAGCGPPSDMIEAFT--KKAPPSQPPRIISSVRSGSRYIITWDHVVA 919
P Y V A N G G PS + E + AP P + + +ITW +
Sbjct: 676 PYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRW 735
Query: 920 LSNESTVTGYKVLYRPDGQH--------DGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDG 971
+ + Y+V +RP G S VP Y ++V+A +
Sbjct: 736 MDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVP------YEIKVQAVNSQ 789
Query: 972 GDGVVSQVKISGA----PTLSPSLLGL-LLPAFGILV 1003
G G QV I + P P L G+ +L + +LV
Sbjct: 790 GKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLV 826
Score = 33.5 bits (75), Expect = 1.0
Identities = 33/140 (23%), Positives = 53/140 (37%), Gaps = 7/140 (5%)
Query: 644 DPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVG 703
D ++ N + L P+ Y V A N GRG T P P +
Sbjct: 864 DHVVVPANTTSVILSGLRPYSSYHLEVQAFN--GRGSGPASEFTFSTPEGVPG-HPEALH 920
Query: 704 GGGGRNRELTITWAP-LSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDET 762
N L + W P LS H G GY++++ P D +++ D H
Sbjct: 921 LECQSNTSLLLRWQPPLS---HNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTD 977
Query: 763 MSPSTAFQVKVKAFNNKGDG 782
+SP ++ +++A +G G
Sbjct: 978 LSPHLRYRFQLQATTKEGPG 997
>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
[Homo sapiens]
Length = 1224
Score = 344 bits (882), Expect = 3e-94
Identities = 267/962 (27%), Positives = 426/962 (44%), Gaps = 86/962 (8%)
Query: 31 IFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVIN 90
I ++ + +P + + C A+ +P P + W + T R +
Sbjct: 37 IIKQSKVQVAFPFDEY---FQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFR 93
Query: 91 NPDKQKDA---GIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLC 147
P++ + G Y C ASN G+ S E + FP E+ + V+EG +VL C
Sbjct: 94 IPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPC 153
Query: 148 DPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGN-YSCFVSSPS 206
+PP P L W+ E I D+R ++SQ G+LY ANVE D N Y CF + P
Sbjct: 154 NPPKGLPP-LHIYWMNIELE-HIEQDERVYMSQ-KGDLYFANVEEKDSRNDYCCFAAFPR 210
Query: 207 ITKSVFSKFIPLIPI---------PERTTKPYPADIVVQFK--------------DVYAL 243
+ +++ K + + T A+ + Q K + L
Sbjct: 211 L-RTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITIL 269
Query: 244 MGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTS-GAVLKIFNIQLEDEGIYECEAE 302
G+ + LECFA G P P + W K+ +P E + G LKI N+ +D+G Y C A
Sbjct: 270 KGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTAS 329
Query: 303 NIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNG----- 357
N G H + V+ P W + GS+ C A G+P PTI+W NG
Sbjct: 330 NFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDN 389
Query: 358 YAYHKGELRLYDVTFEN-----AGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKK 412
+ + + +++F N +YQC A N +G I ANA + ++ + P + +
Sbjct: 390 HPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKD-GEN 448
Query: 413 ILAAKGGRVIIECKPKAAPKPKFSWSKGTEWL-VNSSRILIWEDGSLEINNITRNDGGIY 471
G + C+ A+P+ SW K E + R I+E+G+L+IN T D G Y
Sbjct: 449 YATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSY 508
Query: 472 TCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPAL--DLTFVW 529
+C+ EN GK T L I + T++ ++P N I + C + D L L W
Sbjct: 509 SCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSW 568
Query: 530 SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVV 589
S +G + N + ++ L I N L+ G Y C+A T +D+++ + V
Sbjct: 569 SKDGEAFEINGT----EDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTV 624
Query: 590 RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDD--WKDAKTDPPI 647
P PP L + + + SV LTW G+D++S IS+Y ++ + + W++
Sbjct: 625 LDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTR---- 680
Query: 648 IEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGG 707
++G + L P++ Y+FRV+A N +GR +PS PS+ +T AAP+ P ++
Sbjct: 681 VQGKKTTV-ILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQAS 739
Query: 708 RNRELTITWAPLSREYHYGNNFGYIVAFKPFDGE-EWKKVTVTNPDTGRYVHKDETMSPS 766
+ +E+ I W PL G Y V +KP EW++ TVTN H M+P+
Sbjct: 740 QPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTN-------HTLRVMTPA 792
Query: 767 --TAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEK 824
+ VKV+A N G GP + S +D P AP GV V++S+ + V W V +
Sbjct: 793 VYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKD 852
Query: 825 IV----ESYQIRYW--------AAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGA 872
V + YQI +W H KE N ++ + Q S + +L +++ + V A
Sbjct: 853 RVHGRLKGYQINWWKTKSLLDGRTHPKE--VNILRFSGQRNSGMVPSLDAFSEFHLTVLA 910
Query: 873 CNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVL 932
NS G GP S+ T + P QP + ++W L+ +TGY +
Sbjct: 911 YNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLN--GNLTGYLLQ 968
Query: 933 YR 934
Y+
Sbjct: 969 YQ 970
Score = 127 bits (319), Expect = 5e-29
Identities = 211/945 (22%), Positives = 361/945 (38%), Gaps = 123/945 (13%)
Query: 19 LAVSEEDKGFGPIFEEQPINTIYPEESLEGK-VSLNCRARASPFPVYKWRMNNGDVDLTS 77
+A+SEE + P + P I P E EG + L C P++ + MN +
Sbjct: 117 IAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQ 176
Query: 78 DR--YSMVGGNLVINNPDKQKDAGIYYCLAS-----------------NNYGMVRSTEAT 118
D Y G+L N +++ Y C A+ N+ + ++
Sbjct: 177 DERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSS 236
Query: 119 LSFG-------------YLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNE 165
G L P + + +G+ ++L C + + + +
Sbjct: 237 TEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGD 296
Query: 166 FPVFITMDKRRFVSQTNGN-LYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPER 224
P K R + G L I NV DKGNY C S+ + F ++ P R
Sbjct: 297 LP------KGRETKENYGKTLKIENVSYQDKGNYRCTASN--FLGTATHDFHVIVEEPPR 348
Query: 225 -TTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPM---PSTAEISTS 280
T KP A VY+ G N L C A G P P I+WR P+ P ++
Sbjct: 349 WTKKPQSA--------VYST-GSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFP 399
Query: 281 GAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTE---VDIGSDL 337
+ N+Q +Y+CEA N+ G A I V ++ D E +G
Sbjct: 400 REI-SFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQ-TKDGENYATVVGYSA 457
Query: 338 YWPCVATGKPIPTIRWLK-------NGYAYH---KGELRLYDVTFENAGMYQCIAENTYG 387
+ C P + W K G YH G L++ T E+AG Y C EN G
Sbjct: 458 FLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIG 517
Query: 388 --AIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAP----KPKFSWSK-G 440
A+ AN +++ NP K+ + + C+ K K SWSK G
Sbjct: 518 KTAVTANLDIRNATKLRVSPKNPRIPKLHMLE-----LHCESKCDSHLKHSLKLSWSKDG 572
Query: 441 TEWLVNSS---RILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRII 497
+ +N + RI+I + +L I+N+T D GIY C A A + + D +
Sbjct: 573 EAFEINGTEDGRIII-DGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLD---VP 628
Query: 498 LAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDF--NKENI-HYQRNFMLDSN 554
P N ++ +N +++ +++ D + + Y+++F NKE ++ +
Sbjct: 629 DPPENLHLSERQNRSVRL--TWEAGADHNS--NISEYIVEFEGNKEEPGRWEELTRVQGK 684
Query: 555 GELLIRNAQ--LKHAGRYTCTAQTIVDNSSASADLVVRGPPGP---PGGLRIEDIRATSV 609
+I +++ R + S +D P P P +R++ + +
Sbjct: 685 KTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEM 744
Query: 610 ALTWS--RGSDNHSPISKYTIQTKTILSD-DWKDAKTDPPIIEGNMEAARAVDLIPWMEY 666
+ W + + + P +Y + K + +W++ R + + Y
Sbjct: 745 IIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETV-------TNHTLRVMTPAVYAPY 797
Query: 667 EFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYG 726
+ +V A N LG G P S + + P+ AP G + + +TW+ + ++ +G
Sbjct: 798 DVKVQAINQLGSG-PDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHG 856
Query: 727 NNFGYIVAF----KPFDGEEW-KKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGD 781
GY + + DG K+V + R ++ + F + V A+N+KG
Sbjct: 857 RLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGA 916
Query: 782 GPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHW--EHVLEKIVESYQIRYWAAHDK 839
GP S + + + P E PT + V + ++ W L + Y ++Y +D
Sbjct: 917 GPESEPYIFQTPEGVP-EQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDT 975
Query: 840 EEAA--NRVQVTS-QEYSARLENLLPDTQYFIEVGACNSAGCGPP 881
E N + +T+ + S L NL T+Y + AC S GCG P
Sbjct: 976 YEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKP 1020
Score = 74.3 bits (181), Expect = 5e-13
Identities = 182/847 (21%), Positives = 288/847 (34%), Gaps = 142/847 (16%)
Query: 214 KFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS 273
KF I IP + + P I V + +EC A GNP P W K P
Sbjct: 20 KFSKAIEIPS-SVQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYF 78
Query: 274 TAEISTSGAVLKIFNIQLED-----EGIYECEAENIRG-KDKHQARIYVQAFPEWV-EHI 326
T F I E +G Y C A N G + V + P++ E I
Sbjct: 79 TDHRIIPSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKI 138
Query: 327 NDTEVDIGSDLYWPC-VATGKPIPTIRWLKNGYAYHKGELRLY-----DVTFENA----- 375
+ EV+ G + PC G P I W+ + + + R+Y D+ F N
Sbjct: 139 DPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDS 198
Query: 376 -GMYQCIA----------------------------ENTYGAIYANA--ELKILALAPTF 404
Y C A +T AN+ + K L P
Sbjct: 199 RNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPT 258
Query: 405 EMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNIT 464
E + I KG +++EC + P P+ W+K L +L+I N++
Sbjct: 259 ESGS-ESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVS 317
Query: 465 RNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALD 524
D G Y C A N G A +++ +P R P +A + G N + C A +P
Sbjct: 318 YQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEP--Q 375
Query: 525 LTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDN--SS 582
T W NG +D N + + + E+ N Q H Y C A + ++
Sbjct: 376 PTIKWRVNGSPVD----NHPFAGDVVFPR--EISFTNLQPNHTAVYQCEASNVHGTILAN 429
Query: 583 ASADLVVRGP-------------PGPPGGLRIEDIRATSVALTWSRGSD-------NHSP 622
A+ D+V P G L E + ++W + + +
Sbjct: 430 ANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHI 489
Query: 623 ISKYTIQTKTILSDD------WKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTL 676
T+Q +D W + + N++ A L RV N
Sbjct: 490 YENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKL--------RVSPKN-- 539
Query: 677 GRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHY-GNNFGYIVAF 735
P IP + + + S + L ++W+ + G G I+
Sbjct: 540 ----PRIPKLHM-LELHCESKCDSHL------KHSLKLSWSKDGEAFEINGTEDGRII-- 586
Query: 736 KPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQD 795
DG VT D G Y T S A +V + D P +L ++ Q+
Sbjct: 587 --IDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVP-DPPENLH--LSERQN 641
Query: 796 APSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQE--Y 853
E G H ++ E IVE +KEE ++T +
Sbjct: 642 RSVRLTWEAGAD---------HNSNISEYIVEF-------EGNKEEPGRWEELTRVQGKK 685
Query: 854 SARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVR----SGSR 909
+ + L P +Y V A N G PS + + PP+ P R ++R
Sbjct: 686 TTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHH--ETPPAAPDRNPQNIRVQASQPKE 743
Query: 910 YIITWDHVVALSNESTVTGYKVLYRPDGQH-DGKLYSTHKHSIEVPIPR-DGEYVVEVRA 967
II W+ + ++ Y+V ++P G + + + H++ V P Y V+V+A
Sbjct: 744 MIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVMTPAVYAPYDVKVQA 803
Query: 968 HSDGGDG 974
+ G G
Sbjct: 804 INQLGSG 810
>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
Length = 1240
Score = 337 bits (864), Expect = 3e-92
Identities = 275/932 (29%), Positives = 411/932 (44%), Gaps = 88/932 (9%)
Query: 50 VSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMV--GGNLVIN-----NPDKQKDAGIY 101
+ + C A+ +P P + W N+ ++ D R SM G LVI+ P++ + G Y
Sbjct: 59 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--GEY 116
Query: 102 YCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRW 161
C A N +G S L +P E V V+EG + L C+PP P + + W
Sbjct: 117 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIF-W 175
Query: 162 LLNEFPVFITMDKRRFVSQT-NGNLYIANVEASD-KGNYSC-----FVSSPSITKSVFSK 214
+ + IT DKR VSQ NG+LY +NV D + +YSC F + K
Sbjct: 176 MSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLK 232
Query: 215 FIPLIPIPERTTK-PYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS 273
+ + ERT YP L G ++ LEC A G P PDI W K +PS
Sbjct: 233 VLTTRGVAERTPSFMYPQGTA---SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 289
Query: 274 T-AEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVD 332
A+ L+I N+ ED G Y C A N G +H + V+A P W++ + +
Sbjct: 290 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 349
Query: 333 IGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------GELRLY-DVTFENAGMYQCI 381
G D C A G P PT++W+ NG G+ ++ D + +YQC
Sbjct: 350 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 409
Query: 382 AENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK-G 440
N +G + ANA + +L + P ++P + I R ++C +P P W K G
Sbjct: 410 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 468
Query: 441 TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 500
++ ++E+GSLEI I + D GIYTC A N GKA + L + DPTRI P
Sbjct: 469 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 528
Query: 501 INADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIR 560
+ G ++C DP+L LT W + Y N M + L I
Sbjct: 529 EDQVARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEPLYIGNRMKKEDDSLTIF 580
Query: 561 NAQLKHAGRYTCTAQTIVDNSSASADLVV---------------RGPPGPPGGLRIEDIR 605
+ G YTC A T +D A A L V +G P P L + D+
Sbjct: 581 GVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLA 640
Query: 606 ATSVALTWSRGSDNHSPISKYTIQTKT--ILSDDWKDAKTDPPIIEGNMEAARAVDLIPW 663
SV LTW G N+SPI+ Y +Q + W D P G++ +A + L P+
Sbjct: 641 ERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP----GSVNSA-VLRLSPY 695
Query: 664 MEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREY 723
+ Y+FRV+A N +G PS+PS R +T GA P P DV G G R + ITW P++
Sbjct: 696 VNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATS 755
Query: 724 HYGNNFGYIVAFKPFDGEE-WKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDG 782
+G N YIV ++ + E W VTV RYV + ++++V+A N+ G G
Sbjct: 756 AFGPNLRYIVKWRRRETREAWNNVTVWG---SRYVVGQTPV--YVPYEIRVQAENDFGKG 810
Query: 783 PYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEK--IVESYQIRYWAAHDKE 840
P + S +D PS AP V+ + I++ W+H I+ Y ++Y A + +
Sbjct: 811 PEPESVIGYSGEDLPS-APRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTK 869
Query: 841 EAANRVQ-VTSQEYSARLENLLPDTQYFIEVGACNSAGCG------PPSDMIEAFTKKAP 893
V+ + + ++ P ++Y + A G G P+ EA AP
Sbjct: 870 VGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAP 929
Query: 894 PSQPPRIISSVRSGSRYIITWDHVVALSNEST 925
P+ PP + + + S T +A + E+T
Sbjct: 930 PTLPPTTVGATGAVSSTDAT---AIAATTEAT 958
Score = 76.3 bits (186), Expect = 1e-13
Identities = 89/383 (23%), Positives = 141/383 (36%), Gaps = 46/383 (12%)
Query: 222 PERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPSTAE 276
P TK D +V +D N+ +EC A GNP P W + + P +
Sbjct: 40 PPTITKQSAKDHIVDPRD-------NILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 92
Query: 277 ISTSGAVLKIFNI---QLEDEGIYECEAENIRGKD-KHQARIYVQAFPEW-VEHINDTEV 331
SG ++ F E EG Y+C A N G ++ R+ V P W E+++ V
Sbjct: 93 RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVV 152
Query: 332 DIGSDLYWPC-VATGKPIPTIRWL----------KNGYAYHKGELRLYDVTFENAGM-YQ 379
G+ L C G P P I W+ K H G+L +V ++ Y
Sbjct: 153 QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 212
Query: 380 CIAENTYGAIYANAE---LKILALAPTFEMNP-------MKKKILAAKGGRVIIECKPKA 429
C A + LK+L E P + +G +++EC
Sbjct: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 272
Query: 430 APKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLV 489
P P +W K L + + +L I N++ D G Y C A N G T ++
Sbjct: 273 VPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 332
Query: 490 ITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNF 549
+ + P N + GE+ + C A+ +P T W NG + N + +
Sbjct: 333 VKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNRE--- 387
Query: 550 MLDSNGELLIRNAQLKHAGRYTC 572
+ ++ R+ Q+ Y C
Sbjct: 388 --VAGDTIIFRDTQISSRAVYQC 408
Score = 50.8 bits (120), Expect = 6e-06
Identities = 40/160 (25%), Positives = 69/160 (43%), Gaps = 8/160 (5%)
Query: 46 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 105
L + L+C SP P +W N +L Y + + +++D GIY C+A
Sbjct: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503
Query: 106 SNNYGMVRSTEATLSFGYLDPFPPEERPEVRV-KEGKGMVLLCDPPYHFPDDLSYRWLLN 164
+N G E + DP PE +V + G + L C + L+ WL +
Sbjct: 504 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560
Query: 165 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 204
+ P++I + + + +L I V D+G+Y+C S+
Sbjct: 561 DEPLYI----GNRMKKEDDSLTIFGVAERDQGSYTCVAST 596
>gi|81158224 neuronal cell adhesion molecule isoform B precursor
[Homo sapiens]
Length = 1183
Score = 312 bits (800), Expect = 9e-85
Identities = 261/948 (27%), Positives = 412/948 (43%), Gaps = 92/948 (9%)
Query: 50 VSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVG---GNLVINNPDKQKDA---GIYYC 103
+ + C A+ P P + W N D+ D + G L+IN + K G+Y C
Sbjct: 58 IVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQC 117
Query: 104 LASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLL 163
A N G S + + E+ + ++ G+ +VL C PP P + + W+
Sbjct: 118 TARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIF-WMD 176
Query: 164 NEFPVFITMDKRRFVSQ-TNGNLYIANVEASD-KGNYSCFVSSPSITKSVFSK---FIPL 218
N F + + VSQ NG+LY +NV D + +Y C+ + T+++ K + +
Sbjct: 177 NSFQ---RLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARF-NHTQTIQQKQPISVKV 232
Query: 219 IPIPE-----------------RTTKPYPADIVV---QFKDVYALMGQNVTLECFALGNP 258
I + E ++++ P + + L G ++LEC A G P
Sbjct: 233 ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLP 292
Query: 259 VPDIRWRKVLEPMPSTAEISTS-GAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQ 317
P I W K +P + + L+I ++ D G Y+C A+N G H + V+
Sbjct: 293 TPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVK 352
Query: 318 AFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYH----------KGELRL 367
A P W+ + + G D C A G P P I WL NG G+ +
Sbjct: 353 AAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTII 412
Query: 368 Y-DVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECK 426
+ +V ++ +YQC A N YG + ANA + +LA P + P +++C
Sbjct: 413 FSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRI-LTPANTLYQVIANRPALLDCA 471
Query: 427 PKAAPKPKFSWSKGTEW-LVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANST 485
+P P W KG + ++ ++ E+G+LEI ++ G YTC A N G A +
Sbjct: 472 FFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNE 531
Query: 486 GTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHY 545
L I DPT I+ P A + G + +C D L LT +W + N+E +
Sbjct: 532 VHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLW------LKDNRE-LPS 584
Query: 546 QRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIR 605
F +D + L++ + +G YTC A T +D+ SASA L V P PP L + D
Sbjct: 585 DERFTVDKD-HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQL 643
Query: 606 ATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPI------IEGNMEAARAVD 659
SV L+W+ G DN+SPI+K+ I +++DA P + + G A+ +
Sbjct: 644 DKSVQLSWTPGDDNNSPITKFII--------EYEDAMHKPGLWHHQTEVSGTQTTAQ-LK 694
Query: 660 LIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPL 719
L P++ Y FRV+A N++G+ PS S + T + P+ P+ V G G L ITW PL
Sbjct: 695 LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPL 754
Query: 720 SREYHYGNNFGYIVAFKPFDG-EEWKKVTVTNPDTGRY-VHKDETMSPSTAFQVKVKAFN 777
+ G Y V+++ DG +EW V V N +Y V T P + +KV+A N
Sbjct: 755 NGFESNGPGLQYKVSWRQKDGDDEWTSVVVAN--VSKYIVSGTPTFVP---YLIKVQALN 809
Query: 778 NKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIV----ESYQIRY 833
+ G P V + +S +D P AP V V V++S+ VHW+ V K + + Y+I Y
Sbjct: 810 DMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYY 869
Query: 834 WAAHDKEEAANR------VQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEA 887
W + R + + L L P + Y + V N G GP S
Sbjct: 870 WKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVF 929
Query: 888 FTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRP 935
T + PS P + + + WD +T Y + Y+P
Sbjct: 930 NTPEGVPSAPSSLKIVNPTLDSLTLEWD--PPSHPNGILTEYTLKYQP 975
Score = 79.3 bits (194), Expect = 2e-14
Identities = 95/396 (23%), Positives = 160/396 (40%), Gaps = 40/396 (10%)
Query: 34 EQPINTIYPE------ESLEGKV-SLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGN 86
E+P + PE E L G V SL C A P P+ W +G + Y
Sbjct: 259 ERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKT 318
Query: 87 LVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLL 146
L I + + D+G Y C+A N G + T + P+ + + G+ L+
Sbjct: 319 LQIIHV-SEADSGNYQCIAKNALGAIHHTISVRV--KAAPYWITAPQNLVLSPGEDGTLI 375
Query: 147 CDPPYHFPDDLSYRWLLNEFPVFITMD--KRRFVSQTNGNLYIANVEASDKGNYSCFVSS 204
C + +S WL N P+ I D R+ T + +NV+ Y C S+
Sbjct: 376 CRANGNPKPRIS--WLTNGVPIEIAPDDPSRKIDGDT---IIFSNVQERSSAVYQCNASN 430
Query: 205 PSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRW 264
+ + F+ ++ P R PA+ + Q + + L+C G+P+P I W
Sbjct: 431 -EYGYLLANAFVNVLAEPPRILT--PANTLYQ-----VIANRPALLDCAFFGSPLPTIEW 482
Query: 265 RKVLEPMPSTAEIST--SGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEW 322
K + +I L+I Q + G Y C A N G K++ + ++ P W
Sbjct: 483 FKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKD-PTW 541
Query: 323 -VEHINDTEVDIGSDLYWPCVATGKPI--PTIRWLKNG--------YAYHKGELRLYDVT 371
V+ V GS + + C T+ WLK+ + K L + DV+
Sbjct: 542 IVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVS 601
Query: 372 FENAGMYQCIAENTYGAIYANAELKILALA-PTFEM 406
+++G Y C+A T ++ A+A L ++ + P F++
Sbjct: 602 DDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDL 637
Score = 73.2 bits (178), Expect = 1e-12
Identities = 95/427 (22%), Positives = 164/427 (38%), Gaps = 73/427 (17%)
Query: 222 PERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPSTAE 276
P T+ P D ++ ++ N+ ++C A G P P W + ++ P
Sbjct: 39 PPTITQQSPKDYIIDPRE-------NIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTM 91
Query: 277 ISTSGAVLKIFNIQLED-----EGIYECEAENIRGKD-KHQARIYVQAFPEWV-EHINDT 329
+G + I NI E EG+Y+C A N RG + + P W E +
Sbjct: 92 KPGTGTL--IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPI 149
Query: 330 EVDIGSDLYWPC-VATGKPIPTIRWLKNGYAYHKGELRLY-----DVTFENA------GM 377
+ G L PC G P P I W+ N + R+ D+ F N
Sbjct: 150 TLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTRED 209
Query: 378 YQCIAENTYGAIYANAE---LKILAL-------------------------APTF---EM 406
Y C A + + +K++++ PTF E
Sbjct: 210 YICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEG 269
Query: 407 NPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRN 466
N K+ L +G + +EC + P P W+K L + + + +L+I +++
Sbjct: 270 NASNKEEL--RGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEA 327
Query: 467 DGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLT 526
D G Y C A+N G + T ++ + I AP N ++ GE+ T+ C A+ +P ++
Sbjct: 328 DSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRIS 387
Query: 527 FVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASAD 586
W NG I+ ++ + +D + ++ N Q + + Y C A A+A
Sbjct: 388 --WLTNGVPIEIAPDD----PSRKIDGD-TIIFSNVQERSSAVYQCNASNEYGYLLANAF 440
Query: 587 LVVRGPP 593
+ V P
Sbjct: 441 VNVLAEP 447
Score = 43.9 bits (102), Expect = 8e-04
Identities = 29/99 (29%), Positives = 48/99 (48%), Gaps = 8/99 (8%)
Query: 398 LALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK-GTEWLVNSSRILIWE-- 454
L PT K I+ + ++I+C+ K P P FSW++ GT + ++ ++ +
Sbjct: 36 LVQPPTITQQSPKDYIIDPREN-IVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPG 94
Query: 455 DGSLEINNITRNDG----GIYTCFAENNRGKANSTGTLV 489
G+L IN ++ G+Y C A N RG A S +V
Sbjct: 95 TGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVV 133
>gi|81158226 neuronal cell adhesion molecule isoform A precursor
[Homo sapiens]
Length = 1304
Score = 308 bits (789), Expect = 2e-83
Identities = 262/958 (27%), Positives = 413/958 (43%), Gaps = 102/958 (10%)
Query: 50 VSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVG---GNLVINNPDKQKDA---GIYYC 103
+ + C A+ P P + W N D+ D + G L+IN + K G+Y C
Sbjct: 64 IVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQC 123
Query: 104 LASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLL 163
A N G S + + E+ + ++ G+ +VL C PP P + + W+
Sbjct: 124 TARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIF-WMD 182
Query: 164 NEFPVFITMDKRRFVSQ-TNGNLYIANVEASD-KGNYSCFVSSPSITKSVFSK---FIPL 218
N F + + VSQ NG+LY +NV D + +Y C+ + T+++ K + +
Sbjct: 183 NSFQ---RLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARF-NHTQTIQQKQPISVKV 238
Query: 219 IPIPE-----------------RTTKPYPADIVV---QFKDVYALMGQNVTLECFALGNP 258
I + E ++++ P + + L G ++LEC A G P
Sbjct: 239 ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLP 298
Query: 259 VPDIRWRKVLEPMPSTAEISTS-GAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQ 317
P I W K +P + + L+I ++ D G Y+C A+N G H + V+
Sbjct: 299 TPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVK 358
Query: 318 AFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYH----------KGELRL 367
A P W+ + + G D C A G P P I WL NG G+ +
Sbjct: 359 AAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTII 418
Query: 368 Y-DVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECK 426
+ +V ++ +YQC A N YG + ANA + +LA P + P +++C
Sbjct: 419 FSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRI-LTPANTLYQVIANRPALLDCA 477
Query: 427 PKAAPKPKFSWSKGTEW-LVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANST 485
+P P W KG + ++ ++ E+G+LEI ++ G YTC A N G A +
Sbjct: 478 FFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNE 537
Query: 486 GTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHY 545
L I DPT I+ P A + G + +C D L LT +W + N+E +
Sbjct: 538 VHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLW------LKDNRE-LPS 590
Query: 546 QRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGP----------PGP 595
F +D + L++ + +G YTC A T +D+ SASA L V P P P
Sbjct: 591 DERFTVDKD-HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNP 649
Query: 596 PGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPI------IE 649
P L + D SV L+W+ G DN+SPI+K+ I+ ++DA P + +
Sbjct: 650 PFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIE--------YEDAMHKPGLWHHQTEVS 701
Query: 650 GNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRN 709
G A+ + L P++ Y FRV+A N++G+ PS S + T + P+ P+ V G G
Sbjct: 702 GTQTTAQ-LKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEP 760
Query: 710 RELTITWAPLSREYHYGNNFGYIVAFKPFDG-EEWKKVTVTNPDTGRY-VHKDETMSPST 767
L ITW PL+ G Y V+++ DG +EW V V N +Y V T P
Sbjct: 761 DNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVAN--VSKYIVSGTPTFVP-- 816
Query: 768 AFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIV- 826
+ +KV+A N+ G P V + +S +D P AP V V V++S+ VHW+ V K +
Sbjct: 817 -YLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIR 875
Query: 827 ---ESYQIRYWAAHDKEEAANR------VQVTSQEYSARLENLLPDTQYFIEVGACNSAG 877
+ Y+I YW + R + + L L P + Y + V N G
Sbjct: 876 GHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKG 935
Query: 878 CGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRP 935
GP S T + PS P + + + WD +T Y + Y+P
Sbjct: 936 EGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWD--PPSHPNGILTEYTLKYQP 991
Score = 83.6 bits (205), Expect = 9e-16
Identities = 96/392 (24%), Positives = 158/392 (40%), Gaps = 39/392 (9%)
Query: 34 EQPINTIYPE------ESLEGKV-SLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGN 86
E+P + PE E L G V SL C A P P+ W +G + Y
Sbjct: 265 ERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKT 324
Query: 87 LVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLL 146
L I + + D+G Y C+A N G + T + P+ + + G+ L+
Sbjct: 325 LQIIHV-SEADSGNYQCIAKNALGAIHHTISVRV--KAAPYWITAPQNLVLSPGEDGTLI 381
Query: 147 CDPPYHFPDDLSYRWLLNEFPVFITMD--KRRFVSQTNGNLYIANVEASDKGNYSCFVSS 204
C + +S WL N P+ I D R+ T + +NV+ Y C S+
Sbjct: 382 CRANGNPKPRIS--WLTNGVPIEIAPDDPSRKIDGDT---IIFSNVQERSSAVYQCNASN 436
Query: 205 PSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRW 264
+ + F+ ++ P R PA+ + Q + + L+C G+P+P I W
Sbjct: 437 -EYGYLLANAFVNVLAEPPRILT--PANTLYQ-----VIANRPALLDCAFFGSPLPTIEW 488
Query: 265 RKVLEPMPSTAEIST--SGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEW 322
K + +I L+I Q + G Y C A N G K++ + ++ P W
Sbjct: 489 FKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKD-PTW 547
Query: 323 -VEHINDTEVDIGSDLYWPCVATGKPI--PTIRWLKNG--------YAYHKGELRLYDVT 371
V+ V GS + + C T+ WLK+ + K L + DV+
Sbjct: 548 IVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVS 607
Query: 372 FENAGMYQCIAENTYGAIYANAELKILALAPT 403
+++G Y C+A T ++ A+A L ++A PT
Sbjct: 608 DDDSGTYTCVANTTLDSVSASAVLSVVAPTPT 639
Score = 73.2 bits (178), Expect = 1e-12
Identities = 95/427 (22%), Positives = 164/427 (38%), Gaps = 73/427 (17%)
Query: 222 PERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPSTAE 276
P T+ P D ++ ++ N+ ++C A G P P W + ++ P
Sbjct: 45 PPTITQQSPKDYIIDPRE-------NIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTM 97
Query: 277 ISTSGAVLKIFNIQLED-----EGIYECEAENIRGKD-KHQARIYVQAFPEWV-EHINDT 329
+G + I NI E EG+Y+C A N RG + + P W E +
Sbjct: 98 KPGTGTL--IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPI 155
Query: 330 EVDIGSDLYWPC-VATGKPIPTIRWLKNGYAYHKGELRLY-----DVTFENA------GM 377
+ G L PC G P P I W+ N + R+ D+ F N
Sbjct: 156 TLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTRED 215
Query: 378 YQCIAENTYGAIYANAE---LKILAL-------------------------APTF---EM 406
Y C A + + +K++++ PTF E
Sbjct: 216 YICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEG 275
Query: 407 NPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRN 466
N K+ L +G + +EC + P P W+K L + + + +L+I +++
Sbjct: 276 NASNKEEL--RGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEA 333
Query: 467 DGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLT 526
D G Y C A+N G + T ++ + I AP N ++ GE+ T+ C A+ +P ++
Sbjct: 334 DSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRIS 393
Query: 527 FVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASAD 586
W NG I+ ++ + +D + ++ N Q + + Y C A A+A
Sbjct: 394 --WLTNGVPIEIAPDD----PSRKIDGD-TIIFSNVQERSSAVYQCNASNEYGYLLANAF 446
Query: 587 LVVRGPP 593
+ V P
Sbjct: 447 VNVLAEP 453
Score = 44.7 bits (104), Expect = 4e-04
Identities = 30/102 (29%), Positives = 50/102 (49%), Gaps = 8/102 (7%)
Query: 395 LKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK-GTEWLVNSSRILIW 453
L+ L PT K I+ + ++I+C+ K P P FSW++ GT + ++ ++
Sbjct: 39 LEDLVQPPTITQQSPKDYIIDPREN-IVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTM 97
Query: 454 E--DGSLEINNITRNDG----GIYTCFAENNRGKANSTGTLV 489
+ G+L IN ++ G+Y C A N RG A S +V
Sbjct: 98 KPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVV 139
Score = 43.5 bits (101), Expect = 0.001
Identities = 76/347 (21%), Positives = 128/347 (36%), Gaps = 41/347 (11%)
Query: 570 YTCTAQTIVDNSSASADLVVRGPPGP------PGGLRIEDIRATSVALTWS-------RG 616
Y Q + D A VV G G PG +R+ + +T + W RG
Sbjct: 817 YLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRG 876
Query: 617 SDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTL 676
I Y +T++ + + + +G+ L P+ Y V N
Sbjct: 877 HLQGYRI--YYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGK 934
Query: 677 GRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFK 736
G G P+ P T P+ APS + LT+ W P S + G Y + ++
Sbjct: 935 GEG-PASPDRVFNTPEGVPS-APSSLKIVNPTLDSLTLEWDPPS--HPNGILTEYTLKYQ 990
Query: 737 PFDG--EEWKKVTVTNP-DTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSA 793
P + E V + P + R+ K+ ++ ST ++ A + G G + +
Sbjct: 991 PINSTHELGPLVDLKIPANKTRWTLKN--LNFSTRYKFYFYAQTSAGSGSQITEEAVTTV 1048
Query: 794 QDAPSEAPTEVGV--------------KVLSSSEISVHWEHVLEKIVESYQIRYWAAHDK 839
+A P +VG + + ++ WE+ + V Y + Y A K
Sbjct: 1049 DEA-GILPPDVGAGKVQAVNPRISNLTAAAAETYANISWEYEGPEHVNFY-VEYGVAGSK 1106
Query: 840 EEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIE 886
EE + S+ + L+ L+P T Y + VGA +G D+ E
Sbjct: 1107 EEWRKEIVNGSRSFFG-LKGLMPGTAYKVRVGAVGDSGFVSSEDVFE 1152
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 282 bits (722), Expect = 1e-75
Identities = 257/1023 (25%), Positives = 437/1023 (42%), Gaps = 89/1023 (8%)
Query: 10 LVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEG-KVSLNCRARASPFPVYKWRM 68
L+ + + A++++D P F+ +P P+ LEG ++ L C A S +KW
Sbjct: 86 LLALQLHLLRALAQDD--VAPYFKTEPG---LPQIHLEGNRLVLTCLAEGSWPLEFKWMR 140
Query: 69 NNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFP 128
++ ++ S Y + +L ++ DAG Y C+ N G + ++ + Y+ F
Sbjct: 141 DDSELTTYSSEYKYIIPSL------QKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFM 194
Query: 129 PEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIA 188
++ + V +G+ +L P +P W + + R L I
Sbjct: 195 DTDQRKT-VSQGRAAILNLLPITSYPRP-QVTWFREGHKI---IPSNRIAITLENQLVIL 249
Query: 189 NVEASDKGNYSCFVSSPSITKSVFSKFIPL-IPIPERTTKPYPADIVVQFKDVYALMGQN 247
SD G Y + ++ S FI L I T + IVV + + G +
Sbjct: 250 ATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSS 309
Query: 248 -VTLECFALGNPVPD--IRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENI 304
TLEC A PV D + W++ + T+ + + G L I N D G Y CEA +
Sbjct: 310 ETTLECIASARPVEDLSVTWKR--NGVRITSGLHSFGRRLTISNPTSADTGPYVCEAA-L 366
Query: 305 RGKDKHQARI----------YVQAFPEW-VEHINDTEVDIGSDLYWPCVATGKPIPTIRW 353
G AR Y A PE + + VDIG C A G P+PT++W
Sbjct: 367 PGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIG------CQAMGVPLPTLQW 420
Query: 354 LKNGYAYHK-----------GELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAP 402
K+ + + G LR+ + E++G++QC A N G I + L + +AP
Sbjct: 421 YKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAP 480
Query: 403 TFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSS----RILIWEDGSL 458
F P+ + G I+ C+ APKP +W + L + S R ++ E G L
Sbjct: 481 VFTQRPVDTTV--TDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGL 538
Query: 459 EINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAAS 518
+I + D G YTC+A N G N++ TL + + T I+ P + + G AT+ C A+
Sbjct: 539 QIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGAT 598
Query: 519 FDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIV 578
DP + L +VW + + + + +++ +G LLI G Y+C +
Sbjct: 599 HDPRVSLRYVWKKDNVALTPSSTS-----RIVVEKDGSLLISQTWSGDIGDYSCEIVSEG 653
Query: 579 DNSSASADLVVRGPPGPPGGLRI--EDIRATSVALTWSRGSDNHSPISKYTIQTKTILSD 636
N S A L V P P L + + +V L+W R D +SPI Y ++ LS+
Sbjct: 654 GNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVE----LSE 709
Query: 637 DWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPN 696
+ K + M L P Y+FRV A N +GRG+ S ++R+ P+
Sbjct: 710 NNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPS 769
Query: 697 VAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFD-GEEWKKVTVTNPDTGR 755
P ++ G N+ + + W P H G GYI+ ++ E+++ +T+P+
Sbjct: 770 APPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNY 829
Query: 756 YVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEIS 815
+ D + T ++++V A+N G G +S + Q P+ P V + ++S+ I
Sbjct: 830 CLVTD--LIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQ 887
Query: 816 VHW----EHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQ---EYSARLENLLPDTQYFI 868
W + + I + Y++ W A D EA V + + + NL T YF
Sbjct: 888 FLWNPPPQQFINGINQGYKLLAWPA-DAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFT 946
Query: 869 EVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTG 928
V + G GPPS +T++ P + + + ++W L +TG
Sbjct: 947 SVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQE--PLEKNGIITG 1004
Query: 929 YKVLYRPDGQHDGKL-----YSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKI-S 982
Y++ + G++D +L +TH++ I+ + Y ++V A + G G+V+ I S
Sbjct: 1005 YQISWEVYGRNDSRLTHTLNSTTHEYKIQ-GLSSLTTYTIDVAAVTAVGTGLVTSSTISS 1063
Query: 983 GAP 985
G P
Sbjct: 1064 GVP 1066
Score = 120 bits (300), Expect = 8e-27
Identities = 95/373 (25%), Positives = 159/373 (42%), Gaps = 32/373 (8%)
Query: 590 RGPPGPPGGLRIE--DIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPI 647
R P PP L + ++ A S+ L W GSD SPI +T+Q + + +W+ +
Sbjct: 1474 RERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSS--- 1530
Query: 648 IEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGG 707
I A L P+ Y+ R+ ATN +G + S + + T P P V
Sbjct: 1531 ISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH 1590
Query: 708 RNRELTITWAPLSREYHYGNNFGYIVAFKPFD---GEEWKKVTVTNP----------DTG 754
+ I W P E G GY + ++ + G + T+ NP +
Sbjct: 1591 TTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSF 1650
Query: 755 RYVHKDET--------MSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGV 806
+ V+ T + ++V + A+N G+ P S + + AP+ AP V V
Sbjct: 1651 KTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQV 1710
Query: 807 KVLSSSEISVHWEHVLEKI----VESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLP 862
L++S++ V W+ + ++ Y+I YW A + E + E RL+NL
Sbjct: 1711 TPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTS 1770
Query: 863 DTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSN 922
T+Y + + A N+AG GP SD + T +A P P + S + + ++W A +
Sbjct: 1771 HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAAN- 1829
Query: 923 ESTVTGYKVLYRP 935
+ GY+V+Y P
Sbjct: 1830 -GILQGYRVVYEP 1841
Score = 92.0 bits (227), Expect = 2e-18
Identities = 85/359 (23%), Positives = 153/359 (42%), Gaps = 30/359 (8%)
Query: 593 PGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNM 652
PG G L +I TS+ ++W + + I+ Y I + +D + T +
Sbjct: 972 PGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHT----LNSTT 1027
Query: 653 EAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNV--APSDVGGGGGRNR 710
+ L Y V A +G G + ++ + G P++ APS++ R
Sbjct: 1028 HEYKIQGLSSLTTYTIDVAAVTAVGTG---LVTSSTISSGVPPDLPGAPSNLVISNISPR 1084
Query: 711 ELTITWAP-------LSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETM 763
T+ + P +SR G G I D EEW + + + + +
Sbjct: 1085 SATLQFRPGYDGKTSISRWIVEGQ-VGAIG-----DEEEWVTLYEEENEPDAQMLEIPNL 1138
Query: 764 SPSTAFQVKVKAFNNKGDGPYSLVA-VINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVL 822
+P T ++ ++K N G PYS + VI + Q P APT V V+ S + + + W +
Sbjct: 1139 TPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLP 1198
Query: 823 EKIVES------YQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSA 876
+ Y+I+YW + + A +V E +E L +Y +++ A N+
Sbjct: 1199 DSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAV 1258
Query: 877 GCGPPSDMIEAFTKKAPPSQPPRIISS-VRSGSRYIITWDHVVALSNESTVTGYKVLYR 934
G GP S+++ T+++ PS P +S+ S ++ ++TW V + GYK+L+R
Sbjct: 1259 GAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFR 1317
Score = 85.9 bits (211), Expect = 2e-16
Identities = 102/445 (22%), Positives = 172/445 (38%), Gaps = 56/445 (12%)
Query: 574 AQTIVDNSSASADLVVR----GPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQ 629
A T + N S L++ PGPP L ++R TSV + W + + I Y I
Sbjct: 1355 AFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIA 1414
Query: 630 TKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIK 689
+ S + + + A DL P Y FR+ A G GEP + + I
Sbjct: 1415 YRLASSSPHTFTTVE---VGATVRQFTATDLAPESAYIFRLSAKTRQGWGEP-LEATVIT 1470
Query: 690 TDGAAPNVAPSD--VGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVT 747
T+ P + V R L + W P S F V P + +
Sbjct: 1471 TEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSS 1530
Query: 748 VTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSL-VAVINSAQDAPSEAPTEVGV 806
+++ T V + + P T++++++KA N+ GD +S + + QD P E P V
Sbjct: 1531 ISHEATACVV---DRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSA 1587
Query: 807 KVLSSSEISVHW----EHVLEKIVESYQIRY----------------------WAAHDKE 840
++S + + W + L +++ Y+I Y A +
Sbjct: 1588 TPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQ 1647
Query: 841 EAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRI 900
+ V +S L +L +Y + + A N G P S +E F +A P+ P+
Sbjct: 1648 SSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQN 1707
Query: 901 IS-SVRSGSRYIITWDHVVALSNESTVTGYKVLY-RPDGQHDGKLYSTHKHSI---EVPI 955
+ + + S+ +TWD S + GYK+ Y D Q++ T K + P+
Sbjct: 1708 VQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNE-----TEKMKVLFLPEPV 1762
Query: 956 PR------DGEYVVEVRAHSDGGDG 974
R +Y+V + A + GDG
Sbjct: 1763 VRLKNLTSHTKYLVSISAFNAAGDG 1787
Score = 70.5 bits (171), Expect = 8e-12
Identities = 57/245 (23%), Positives = 98/245 (40%), Gaps = 8/245 (3%)
Query: 659 DLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAP 718
+L WMEYE ++ A N +G G P R +T + P+ AP +V + ++ +TW
Sbjct: 1241 ELEEWMEYELQMQAFNAVGAG-PWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTS 1299
Query: 719 LSREYHYGNNFGYIVAF--KPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAF 776
+ + G GY + F K D E + N + + ++++V AF
Sbjct: 1300 VPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALL---AGLRKFVLYELQVLAF 1356
Query: 777 NNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEK--IVESYQIRYW 834
G+G S ++ +D P + + + + + W+ E I+ YQI Y
Sbjct: 1357 TRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYR 1416
Query: 835 AAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPP 894
A V+V + +L P++ Y + A G G P + T+K
Sbjct: 1417 LASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRER 1476
Query: 895 SQPPR 899
PPR
Sbjct: 1477 PAPPR 1481
Score = 64.7 bits (156), Expect = 4e-10
Identities = 92/365 (25%), Positives = 143/365 (39%), Gaps = 29/365 (7%)
Query: 588 VVRG------PPGPPGGLRIEDIRATSVALTWSR--GSDNHSPISKYTIQTKTILSDDWK 639
VVRG P P + E + +T + LTW+ D + I Y I + K
Sbjct: 1266 VVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRA------K 1319
Query: 640 DAKTDPP--IIEGN-MEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPN 696
D +P I+ GN ++A L ++ YE +V+A +G G PS P +T AP
Sbjct: 1320 DLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPG 1379
Query: 697 VAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRY 756
P + R + I W P E G GY +A++ TV T R
Sbjct: 1380 -PPVRLVFPEVRLTSVRIVWQP--PEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQ 1436
Query: 757 VHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISV 816
+ ++P +A+ ++ A +G G VI + + P E+ V + S+
Sbjct: 1437 FTATD-LAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSL 1495
Query: 817 HWEHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQEYSAR-----LENLLPDTQYFIEVG 871
+ V S IRY+ +E Q S S ++ L P T Y + +
Sbjct: 1496 RLQWVPGSDGAS-PIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLK 1554
Query: 872 ACNSAGCGPPSDMIEAFTK-KAPPSQPPRIISSV-RSGSRYIITWDHVVALSNESTVTGY 929
A N G S EA T + P +PP +S+ + S +I W S + GY
Sbjct: 1555 ATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGY 1614
Query: 930 KVLYR 934
++ YR
Sbjct: 1615 RIYYR 1619
Score = 48.5 bits (114), Expect = 3e-05
Identities = 37/125 (29%), Positives = 52/125 (41%), Gaps = 5/125 (4%)
Query: 574 AQTIVDNSSASADLVVRGPPGPPGGLR--IEDIRATSVALTWSRGSDNHSPISKYTIQTK 631
A+TI A++ G PG R + A+ + L W+ G +P + Y I+ +
Sbjct: 1881 ARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEAR 1940
Query: 632 TILSDDWKDAKTDPPIIEGNMEAARAVD-LIPWMEYEFRVVATNTLGRGEPSIPSNRIKT 690
W D P ++D L + YEFRVVA N G GEPS PS +
Sbjct: 1941 PSDEGLWDMFVKDIP--RSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSA 1998
Query: 691 DGAAP 695
AP
Sbjct: 1999 QVEAP 2003
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 245 bits (626), Expect = 1e-64
Identities = 257/1044 (24%), Positives = 425/1044 (40%), Gaps = 108/1044 (10%)
Query: 3 MWLLVSHLVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEG-KVSLNCRARASPF 61
MW L+ ++ A +++D P F+ +P+ T + LEG ++ L C A S
Sbjct: 1 MWGLLIWTLLALHQIRAARAQDD--VSPYFKTEPVRT---QVHLEGNRLVLTCMAEGSWP 55
Query: 62 PVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSF 121
+KW NN ++ S Y +I + D+ AG Y C+ N G + + +
Sbjct: 56 LEFKWLHNNRELTKFSLEY-----RYMITSLDRTH-AGFYRCIVRNRMGALLQRQTEVQV 109
Query: 122 GYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQT 181
Y+ F E+ + V G+ V+ FP W + + R
Sbjct: 110 AYMGSFEEGEKHQ-SVSHGEAAVIRAPRIASFPQP-QVTWFRDGRKI---PPSSRIAITL 164
Query: 182 NGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPL-IPIPERTTKPYPADIVVQFKDV 240
L I + A D G Y + + S+ I L + P I++ K+
Sbjct: 165 ENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNT 224
Query: 241 YALMGQN-VTLECFALGNPVPDIR--WRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIY 297
+ G + VTLEC A P+ + W+K + + + IS L I N D G Y
Sbjct: 225 SVVAGTSEVTLECVANARPLIKLHIIWKK--DGVLLSGGISDHNRRLTIPNPTGSDAGYY 282
Query: 298 ECEA--------ENIRGKDKHQARIYVQAFPEWVE----HINDTEVDIGSDLYWPCVATG 345
ECEA +RG A + V P++V+ HI E++ D+ PC A G
Sbjct: 283 ECEAVLRSSSVPSVVRG-----AYLSVLEPPQFVKEPERHIT-AEMEKVVDI--PCQAKG 334
Query: 346 KPIPTIRWLKNGYAY-----------HKGELRLYDVTFENAGMYQCIAENTYGAIYANAE 394
P P+I W K+ + G L++ + ++ GM+QC A N G + +
Sbjct: 335 VPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTY 394
Query: 395 LKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSS----RI 450
L + ++AP P+ ++ G V++ C+ AP+P +W KG L + S R
Sbjct: 395 LAVTSIAPNITRGPLDSTVI--DGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRF 452
Query: 451 LIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGEN 510
E GSL I+ +D G YTC A N+RG ++ LV+ TRI P + + G
Sbjct: 453 TPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQ 512
Query: 511 ATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRY 570
A+M C + DP + + ++W +G + LD NG L I G Y
Sbjct: 513 ASMVCGVTHDPRVTIRYIWEKDGATL-----GTESHPRIRLDRNGSLHISQTWSGDIGTY 567
Query: 571 TCTAQTIVDNSSASADLVVRGPPGPPGG--LRIEDIRATSVALTWSRGSDNHSPISKYTI 628
TC + N S SA L VR P P + + ++ LTW++ D +SP+ +Y +
Sbjct: 568 TCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYIL 627
Query: 629 QTK------TILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPS 682
+ T+L A DP ++ L+P Y+FR+ A N +G+G+ S
Sbjct: 628 EMSENNAPWTVLL-----ASVDPKATSVTVKG-----LVPARSYQFRLCAVNDVGKGQFS 677
Query: 683 IPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAF----KPF 738
+ R+ P P +V G N+ + I W P + G GYI+ + P
Sbjct: 678 KDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPV 737
Query: 739 DGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPS 798
G ++K +T+ D + +D + T ++++V A+N+ G G YS + Q P+
Sbjct: 738 -GYQFK--NITDADVNNLLLED--LIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPT 792
Query: 799 EAPTEVGVKVLSSSEISVHWE----HVLEKIVESYQIRYWAAHDKEE---AANRVQVTSQ 851
P V + +S+ I W + I + Y++ W +EE R
Sbjct: 793 VPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDS 852
Query: 852 EYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYI 911
+ + L T+YF V + G GP S T + P + S +
Sbjct: 853 IHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLK 912
Query: 912 ITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDG-----EYVVEVR 966
++W +TGY++ + + + ++ + + ++ + G Y +EV
Sbjct: 913 VSWQE--PGEKNGILTGYRISWEEYNRTNTRV-THYLPNVTLEYRVTGLTALTTYTIEVA 969
Query: 967 AHSDGGDGVVSQVKI-SGAPTLSP 989
A + G G VS I SG P P
Sbjct: 970 AMTSKGQGQVSASTISSGVPPELP 993
Score = 132 bits (333), Expect = 1e-30
Identities = 107/404 (26%), Positives = 177/404 (43%), Gaps = 39/404 (9%)
Query: 570 YTCTAQTIVDNSSASADLVV----RGPPGPPGGLRI--EDIRATSVALTWSRGSDNHSPI 623
+ TAQT A+ LVV R P PP + ED+RA SV L+W GSD SP+
Sbjct: 1373 FRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPV 1432
Query: 624 SKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSI 683
YTIQT+ + S W + N + L P+ Y+FRV ATN +G E S
Sbjct: 1433 RYYTIQTRELPSGRW---ALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSE 1489
Query: 684 PSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPF----- 738
S + T AAP+ AP+ + + I W P + + G G+ + ++
Sbjct: 1490 ESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGL 1549
Query: 739 ----------DGEEWKKVT-------VTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGD 781
G W ++T ++ P +Y + + ++ +++++ +N G+
Sbjct: 1550 RGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQY--ELDNLNKHRRYEIRMSVYNAVGE 1607
Query: 782 GPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWE----HVLEKIVESYQIRYWAAH 837
GP S + + P+ AP V V +++++ V WE ++ Y+I +W A
Sbjct: 1608 GPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQ 1667
Query: 838 DKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQP 897
+ E S +L+NL T Y + V A N+AG GP S + T++A PS P
Sbjct: 1668 RGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAP 1727
Query: 898 PRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDG 941
+ S + + ++W+ + GY+++Y P DG
Sbjct: 1728 SSVKFSELTTTSVNVSWE--APQFPNGILEGYRLVYEPCSPVDG 1769
Score = 108 bits (269), Expect = 3e-23
Identities = 98/362 (27%), Positives = 154/362 (42%), Gaps = 23/362 (6%)
Query: 537 DFNKENI---HYQRNFMLDSNGELLIRNAQLKHAGRYTC--TAQTIVDNSSASADLVVRG 591
++N+ N HY N L+ R L YT A T SA + G
Sbjct: 934 EYNRTNTRVTHYLPNVTLE------YRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSG 987
Query: 592 PP----GPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPI 647
P GPP L I +I SV L + G D + IS++ ++ + + + ++ +
Sbjct: 988 VPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQL 1047
Query: 648 I-EGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGG 706
E + + DL P+ Y FR+ N +G PS PS +I+T A P++AP++V
Sbjct: 1048 SNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRT 1107
Query: 707 GRNRELTITWAPLSREYHYGN--NFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMS 764
L + W PL + GN + GY + + DG K ++ D + E +
Sbjct: 1108 ASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDG-HGKTLSHVVQDRVERDYTIEDLE 1166
Query: 765 PSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEK 824
T ++V+V+AFN G GP+S V + + PS PT V +SS + V W V E
Sbjct: 1167 EWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEA 1226
Query: 825 ----IVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGP 880
+V Y++ Y + + + SA+L L Y ++V A G G
Sbjct: 1227 DRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGS 1286
Query: 881 PS 882
PS
Sbjct: 1287 PS 1288
Score = 85.9 bits (211), Expect = 2e-16
Identities = 116/491 (23%), Positives = 199/491 (40%), Gaps = 64/491 (13%)
Query: 533 GYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIV------DNSSASAD 586
GY + + +++ Q F L R+AQL G+Y ++ D S +
Sbjct: 1234 GYKVMYKEKDSDTQPRFWLVEGNSS--RSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPP 1291
Query: 587 LVVR---GPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKT 643
++ R PGPP G+ ++R TSV L W + + I Y I T + + A
Sbjct: 1292 ILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQI-THRLNTTTANTATV 1350
Query: 644 DPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGE--PSIPSNRIKTDGAAPNVAPSD 701
+ ++ + A L P Y FR+ A G GE ++ K D P P
Sbjct: 1351 E--VLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPM- 1407
Query: 702 VGGGGGRNRELTITWAPLS---REYHYGNNFGYIVAFKPFDGEEW--KKVTVTNPDTGRY 756
V R R + ++W P S Y Y + + W +V++ +
Sbjct: 1408 VQQEDVRARSVLLSWEPGSDGLSPVRY-----YTIQTRELPSGRWALHSASVSHNASSFI 1462
Query: 757 VHKDETMSPSTAFQVKVKAFNNKGDGPYSLVA-VINSAQDAPSEAPTEVGVKVLSSSEIS 815
V + + P T+++ +VKA N+ GD +S + + + Q AP EAPT + V +++ +
Sbjct: 1463 V---DRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVL 1519
Query: 816 VHW----EHVLEKIVESYQIRY-----------WAAHDKEEAANRVQVTSQEYSAR---- 856
+ W E + I+ ++IRY A ++TS YS R
Sbjct: 1520 IRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSM-YSMRNLSR 1578
Query: 857 -------LENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPR-IISSVRSGS 908
L+NL +Y I + N+ G GP S E F +A P+ PR ++ + +
Sbjct: 1579 PSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATAT 1638
Query: 909 RYIITWDHVVALSNESTVTGYKVLY----RPDGQHDGKLYSTHKHSIEVP-IPRDGEYVV 963
+ +TW+ S + GYK+ + R + K ++S+++ + Y+V
Sbjct: 1639 QLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMV 1698
Query: 964 EVRAHSDGGDG 974
V A + GDG
Sbjct: 1699 SVAAFNAAGDG 1709
Score = 84.0 bits (206), Expect = 7e-16
Identities = 100/443 (22%), Positives = 179/443 (40%), Gaps = 62/443 (13%)
Query: 593 PGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNM 652
PGP G L +I TS+ ++W + + ++ Y I W+ E N
Sbjct: 895 PGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRIS--------WE---------EYNR 937
Query: 653 EAARAVDLIPWMEYEFRVVATNTL-----------GRGEPSIPSNRIKTDGAAPNVA--P 699
R +P + E+RV L +G+ + ++ I + G P + P
Sbjct: 938 TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISS-GVPPELPGPP 996
Query: 700 SDVGGGGGRNRELTITWAP-------LSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPD 752
+++G R +T+ + P +SR + G + +GEEW + + +
Sbjct: 997 TNLGISNIGPRSVTLQFRPGYDGKTSISR-WLVEAQVGVVG-----EGEEWLLIHQLSNE 1050
Query: 753 TGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVA-VINSAQDAPSEAPTEVGVKVLSS 811
+ ++P T + +++ N G P S + I + Q P AP V ++ S
Sbjct: 1051 PDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASE 1110
Query: 812 SEISVHWEHVLEKIVES------YQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQ 865
+ + + W + E Y+I+Y + + + V E +E+L T+
Sbjct: 1111 TSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTE 1170
Query: 866 YFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSV-RSGSRYIITWDHVVALSNES 924
Y ++V A N+ G GP S + T+++ PS P +S++ + S ++ W V
Sbjct: 1171 YRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNG 1230
Query: 925 TVTGYKVLYR-PDGQHDGKLYSTHKHSI-EVPIPRDGEYV---VEVRAHSDGGDGVVSQV 979
V GYKV+Y+ D + + +S + G+YV V+V A + GDG S
Sbjct: 1231 LVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSH- 1289
Query: 980 KISGAPTLSPSLLGLLLPAFGIL 1002
P L +L + P GIL
Sbjct: 1290 ----PPILERTLDDVPGPPMGIL 1308
Score = 55.8 bits (133), Expect = 2e-07
Identities = 38/130 (29%), Positives = 59/130 (45%), Gaps = 5/130 (3%)
Query: 569 RYTCTAQTIVDNSSASADLVV---RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISK 625
R+ A+T A++ G PGPPG + I ++++A+ WS G PI++
Sbjct: 1798 RFRIRAKTFTYGPEIEANVTTGPGEGAPGPPG-VPIIVRYSSAIAIHWSSGDPGKGPITR 1856
Query: 626 YTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPS 685
Y I+ + W D P + + + L P + Y+FRV+A N G G PS PS
Sbjct: 1857 YVIEARPSDEGLWDILIKDIPKEVSSYTFSMDI-LKPGVSYDFRVIAVNDYGFGTPSSPS 1915
Query: 686 NRIKTDGAAP 695
+ A P
Sbjct: 1916 QSVPAQKANP 1925
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 225 bits (574), Expect = 1e-58
Identities = 234/944 (24%), Positives = 392/944 (41%), Gaps = 92/944 (9%)
Query: 26 KGFGPIFEEQPIN-TIYPEE---SLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYS 81
K G ++ +QP+ TI P + S+ +VSL+C + W NG++
Sbjct: 303 KVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSW-YRNGEILNPGKNVR 361
Query: 82 MVG---GNLVINNPDKQKDAGIYYC------LASNNYGMVRSTEATLSFGYLDPFPPEER 132
+ G NL++++ K D G Y C L++ +Y V + T P
Sbjct: 362 ITGINHENLIMDHMVKS-DGGAYQCFVRKDKLSAQDYVQVVLEDGT-------PKIISAF 413
Query: 133 PEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQ---TNGN----L 185
E V + + L+C+ ++ W L++ P+ R +SQ + GN L
Sbjct: 414 SEKVVSPAEPVSLMCNVKGTPLPTIT--WTLDDDPILKGGSHR--ISQMITSEGNVVSYL 469
Query: 186 YIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMG 245
I++ + D G Y C ++ + ++ R PA I K++ A+ G
Sbjct: 470 NISSSQVRDGGVYRCTANNSA----------GVVLYQARINVRGPASIR-PMKNITAIAG 518
Query: 246 QNVTLECFALGNPVPDIRWRKV--LEPMPSTAEISTSGAVLKIFNIQLE-DEGIYECEAE 302
++ + C +G P I+W K L P + LK+ ++Q E DEG Y C
Sbjct: 519 RDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVL 578
Query: 303 NIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIP-TIRWLKNGYAY- 360
Q+ P +++ IG ++ PCV +P TI W K+G
Sbjct: 579 VQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIP 638
Query: 361 -----------HKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPM 409
LR+ +++ + G Y CIA N A+ ++L I+ + P F + P
Sbjct: 639 GSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQL-IVRVPPKFVVQPR 697
Query: 410 KKKILAAKGGRVIIECKPKAAPKPKFSW--SKGT-----EWLVNSSRILIWEDGSLEINN 462
+ + K VI+ C + P P W SKG + + + RI + +GSL I +
Sbjct: 698 DQDGIYGKA--VILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKH 755
Query: 463 ITRNDGGIYTCFAENNRGKANSTGT-LVITDPTRIILAPINADITVGENATMQCAASFDP 521
+ D G Y C N+ G S L + P I P T G+ M C A +
Sbjct: 756 VVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEK 815
Query: 522 ALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQL-----KHAGRYTCTAQT 576
+ + W +I N E Y + GE +I Q+ + +G ++C A
Sbjct: 816 PIIVR--WEKEDRII--NPEMARYLVS--TKEVGEEVISTLQILPTVREDSGFFSCHAIN 869
Query: 577 IVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSD 636
L V+ PP PP + I+D++A ++ L W+ G D +SPI+ Y I+ K SD
Sbjct: 870 SYGEDRGIIQLTVQEPPDPPE-IEIKDVKARTITLRWTMGFDGNSPITGYDIECKN-KSD 927
Query: 637 DWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPN 696
W A+ + + +A +D+ P Y R+ A N +G+ EPS I D AAP+
Sbjct: 928 SWDSAQRTKDV-SPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELT-ITADEAAPD 985
Query: 697 VAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTG-- 754
P +V ++ + +TW + G GY + ++ + + + + DT
Sbjct: 986 GPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGD 1045
Query: 755 RYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEI 814
V+ + ++ T + + V+A N G GP S + + +D PS P V S I
Sbjct: 1046 SEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESI 1105
Query: 815 SVHW----EHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEV 870
S+ W + L I++ +++ YWA E +T+ + S L+ L T Y I+V
Sbjct: 1106 SISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQV 1165
Query: 871 GACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITW 914
A AG G S+ I TK+ P P + ++ S S ++W
Sbjct: 1166 LAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSW 1209
Score = 187 bits (476), Expect = 3e-47
Identities = 238/994 (23%), Positives = 388/994 (39%), Gaps = 120/994 (12%)
Query: 49 KVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNN 108
+V L C+A P P Y+W +N ++L+ V G L+ N + D+G Y C SN
Sbjct: 241 RVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIEN--IRPSDSGSYVCEVSNR 298
Query: 109 YGMVRSTEATLSFGYL-DPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFP 167
YG T + Y+ P P +VK G + +D W N
Sbjct: 299 YG----TAKVIGRLYVKQPLKATISPR-KVKSSVGSQVSLSCSVTGTEDQELSWYRNG-E 352
Query: 168 VFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTK 227
+ R + NL + ++ SD G Y CFV ++ + + + + + T K
Sbjct: 353 ILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVV----LEDGTPK 408
Query: 228 PYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS------TAEISTSG 281
I+ F + + V+L C G P+P I W +P+ + I++ G
Sbjct: 409 -----IISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEG 463
Query: 282 AVLKIFNI---QLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLY 338
V+ NI Q+ D G+Y C A N G +QARI V+ P + + + G D Y
Sbjct: 464 NVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PASIRPMKNITAIAGRDTY 522
Query: 339 WPCVATGKPIPTIRWLKNGYAY----------HKGELRLYDVTFE-NAGMYQC---IAEN 384
C G P +I+W KN + G L+L DV E + G Y C +
Sbjct: 523 IHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQ 582
Query: 385 TYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKP-KFSWSKGTEW 443
+ + +K+ FE + G RV I C + P +W K
Sbjct: 583 LSTSQSVHVTVKVPPFIQPFEFPRF------SIGQRVFIPCVVVSGDLPITITWQKDGRP 636
Query: 444 LVNSSRILIWE---DGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 500
+ S + I SL I+N++ G YTC A N L++ P + ++ P
Sbjct: 637 IPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQP 696
Query: 501 INADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIR 560
+ D G+ + C+A P T VW F+ + I + SNG LLI+
Sbjct: 697 RDQDGIYGKAVILNCSAEGYPV--PTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIK 754
Query: 561 NAQLKHAGRYTCTAQTIVD-NSSASADLVVRGP-------------PGPPGGLRIEDIRA 606
+ + +G Y C V + S S L V+ P G +
Sbjct: 755 HVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGE 814
Query: 607 TSVALTWSRGSDNHSP-ISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWME 665
+ + W + +P +++Y + TK E E + ++P +
Sbjct: 815 KPIIVRWEKEDRIINPEMARYLVSTK-----------------EVGEEVISTLQILPTVR 857
Query: 666 YE---FRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSRE 722
+ F A N+ G + I ++ P + DV + R +T+ W
Sbjct: 858 EDSGFFSCHAINSYGE-DRGIIQLTVQEPPDPPEIEIKDV-----KARTITLRWT----M 907
Query: 723 YHYGNN--FGYIVAFKPFDGEEWKKVTVT---NPDTGRYVHKDETMSPSTAFQVKVKAFN 777
GN+ GY + K + W T +P D + PS+ + +++ A N
Sbjct: 908 GFDGNSPITGYDIECKN-KSDSWDSAQRTKDVSPQLNSATIID--IHPSSTYSIRMYAKN 964
Query: 778 NKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHW----EHVLEKIVESYQI-- 831
G S I + + AP P EV ++ +SS I V W +H+ I+ YQI
Sbjct: 965 RIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGY 1024
Query: 832 -RYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTK 890
Y + + V + L+NL TQY + V ACN AG GP S I T
Sbjct: 1025 REYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTL 1084
Query: 891 KAPPSQPPRIISSVRSGSRYI-ITWDHVVALSNESTVTGYKVLY---RPDGQ-HDGKLYS 945
+ PS PP + ++ + I I+W + + + G++V+Y DG+ + K +
Sbjct: 1085 EDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNIT 1144
Query: 946 THKHSIEVP-IPRDGEYVVEVRAHSDGGDGVVSQ 978
T + S+E+ + + Y ++V A + GDGV S+
Sbjct: 1145 TTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSE 1178
Score = 158 bits (399), Expect = 3e-38
Identities = 216/918 (23%), Positives = 358/918 (38%), Gaps = 116/918 (12%)
Query: 50 VSLNCRARASPFPVYKWRMNNGDV-DLTSDRYSMV---GGNLV--INNPDKQ-KDAGIYY 102
VSL C + +P P W +++ + S R S + GN+V +N Q +D G+Y
Sbjct: 424 VSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYR 483
Query: 103 CLASNNYGMVRSTEATLSFGYLDPFPPEERP--EVRVKEGKGMVLLCDP---PYHFPDDL 157
C A+N+ G+V G P RP + G+ + C PY+
Sbjct: 484 CTANNSAGVVLYQARINVRG-----PASIRPMKNITAIAGRDTYIHCRVIGYPYY----- 533
Query: 158 SYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEAS-DKGNYSCFVS-SPSITKSVFSKF 215
S +W N + + R+ + NG L +++V+ D+G Y+C V P ++ S
Sbjct: 534 SIKWYKNSN--LLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHV 591
Query: 216 IPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVP-DIRWRKVLEPMPST 274
+P + F+ +GQ V + C + +P I W+K P+P +
Sbjct: 592 TVKVP-----------PFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGS 640
Query: 275 AEISTSG----AVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTE 330
++ + L+I N+ L G Y C A N +HQ+++ V+ P++V D +
Sbjct: 641 LGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQD 700
Query: 331 VDIGSDLYWPCVATGKPIPTIRW--------------LKNG--YAYHKGELRLYDVTFEN 374
G + C A G P+PTI W NG G L + V E+
Sbjct: 701 GIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEED 760
Query: 375 AGMYQCIAENTYGAIYANA---ELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAP 431
+G Y C N GA + + +KI A+ ++ LA +G + + C
Sbjct: 761 SGYYLCKVSNDVGADVSKSMYLTVKIPAMITSY-----PNTTLATQGQKKEMSCTAHGEK 815
Query: 432 KPKFSWSKG--------TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKAN 483
W K +LV++ + +L+I R D G ++C A N+ G+
Sbjct: 816 PIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDR 875
Query: 484 STGTLVI---TDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDF-N 539
L + DP I + + A T++ FD +T GY I+ N
Sbjct: 876 GIIQLTVQEPPDPPEIEIKDVKA-----RTITLRWTMGFDGNSPIT------GYDIECKN 924
Query: 540 KENIHYQRNFMLDSNGEL---LIRNAQLKHAGRYTCTAQTIVDNSSASADLVV----RGP 592
K + D + +L I + A+ + S S +L + P
Sbjct: 925 KSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAP 984
Query: 593 PGPPGGLRIEDIRATSVALTWSRGSDN--HSPISKYTIQTKTILSDDWKDAKTDPPIIEG 650
GPP + +E I + S+ +TW + + I Y I + + G
Sbjct: 985 DGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSG 1044
Query: 651 NMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNR 710
+ E +L + +Y V A N G G PS T P+ P +V
Sbjct: 1045 DSEVYTLDNLNKFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYPPENVQAIATSPE 1103
Query: 711 ELTITWAPLSREYHYGNNFGYIVAF--KPFDGE--EWKKVTVTNPDTGRYVHKDETMSPS 766
++I+W+ LS+E G G+ V + DGE E K +T T P + + +
Sbjct: 1104 SISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSL-----ELDGLEKY 1158
Query: 767 TAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHW--EHVLEK 824
T + ++V AF GDG S + +D P P V S+S + V W L
Sbjct: 1159 TNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPG-PPAGVKAAAASASMVFVSWLPPLKLNG 1217
Query: 825 IVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDM 884
I+ Y + + +H + + + +S R+ NL + QY + V A SAG G S++
Sbjct: 1218 IIRKYTV--FCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEI 1275
Query: 885 IEAFTKKAPPSQPPRIIS 902
I T + P RI++
Sbjct: 1276 I---TVEPLAKAPARILT 1290
Score = 118 bits (295), Expect = 3e-26
Identities = 140/576 (24%), Positives = 224/576 (38%), Gaps = 60/576 (10%)
Query: 54 CRARASPFPVYKWRMNNGD--VDLTSDRYSMVGGNLVI-----NNPDKQKDAGIYYCLAS 106
C A P +W + G+ D+ R+ G L I ++ YYC A
Sbjct: 46 CPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAE 105
Query: 107 NNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGM-----VLLCDPPYHFPDDLSY-R 160
N G +RS + + +P+ VRV++ K M V C P ++
Sbjct: 106 NPSGKIRSQDVHIKAVLREPYT------VRVEDQKTMRGNVAVFKCIIPSSVEAYITVVS 159
Query: 161 WLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDK-GNYSCFVSSPSITKSVFSKFIPLI 219
W E + RF+ + G LYI +V+ D NY C ++ S L
Sbjct: 160 W---EKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLF 216
Query: 220 PIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEIST 279
+ P I+ F A+ GQ V L C ALG+P PD RW K P+ +
Sbjct: 217 VSDPANSAP---SILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQK 273
Query: 280 SGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYW 339
+ L I NI+ D G Y CE N G K R+YV+ + + +GS +
Sbjct: 274 TVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSL 333
Query: 340 PCVATGKPIPTIRWLKNGYAYHKGE-LRLYDVTFEN----------AGMYQCIAENTYGA 388
C TG + W +NG + G+ +R+ + EN G YQC
Sbjct: 334 SCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRK--DK 391
Query: 389 IYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLV--N 446
+ A ++++ T ++ + + + V + C K P P +W+ + ++
Sbjct: 392 LSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGG 451
Query: 447 SSRI--LIWEDGS----LEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 500
S RI +I +G+ L I++ DGG+Y C A N+ G + + P I P
Sbjct: 452 SHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASI--RP 509
Query: 501 I-NADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLI 559
+ N G + + C P + W N ++ FN R ++NG L +
Sbjct: 510 MKNITAIAGRDTYIHCRVIGYPYYSIK--WYKNSNLLPFN------HRQVAFENNGTLKL 561
Query: 560 RNAQLK-HAGRYTCTAQTIVD-NSSASADLVVRGPP 593
+ Q + G YTC ++S S + V+ PP
Sbjct: 562 SDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPP 597
Score = 66.6 bits (161), Expect = 1e-10
Identities = 217/984 (22%), Positives = 360/984 (36%), Gaps = 157/984 (15%)
Query: 41 YPEESLEGKVSLNCRARASPFPV-YKWRMNN----GDVDLTSDRYSMVGGNLVINNPDKQ 95
+P S+ +V + C + P+ W+ + G + +T D +L I+N
Sbjct: 604 FPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTS-SLRISNLSLM 662
Query: 96 KDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEG---KGMVLLCDPPYH 152
+ G Y C+A N V + PP+ + R ++G K ++L C +
Sbjct: 663 HN-GNYTCIARNEAAAVEHQSQLIV-----RVPPKFVVQPRDQDGIYGKAVILNCSAEGY 716
Query: 153 FPDDLSYRWLLNE-FPVF--ITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSP---S 206
+ +++ P F I ++ R V +NG+L I +V D G Y C VS+
Sbjct: 717 PVPTIVWKFSKGAGVPQFQPIALNGRIQVL-SNGSLLIKHVVEEDSGYYLCKVSNDVGAD 775
Query: 207 ITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK 266
++KS++ T PA I A GQ + C A G +RW K
Sbjct: 776 VSKSMY------------LTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEK 823
Query: 267 ---VLEPMPSTAEISTSG------AVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQ 317
++ P + +ST + L+I ED G + C A N G+D+ ++ VQ
Sbjct: 824 EDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQ 883
Query: 318 AFPEWVE-HINDTEV-------DIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGELRLYD 369
P+ E I D + +G D P TG I KN R D
Sbjct: 884 EPPDPPEIEIKDVKARTITLRWTMGFDGNSPI--TGYDIEC----KNKSDSWDSAQRTKD 937
Query: 370 VT--FENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKP 427
V+ +A + +TY +I A+ +I P+ E+ + A G + +P
Sbjct: 938 VSPQLNSATIIDIHPSSTY-SIRMYAKNRIGKSEPSNELTITADEA-APDGPPQEVHLEP 995
Query: 428 KAAPKPKFSWSKGTEWLVNSS----RILIWE---DGSLEINNITRNDGGIYTCFAENNRG 480
++ + +W + L N +I E G+ + N I+ + G + +N
Sbjct: 996 ISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLN 1055
Query: 481 KANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPAL---------DLTFVWS- 530
K G LV+ R P + +I T++ S+ P ++ WS
Sbjct: 1056 KFTQYG-LVVQACNRAGTGPSSQEIIT---TTLEDVPSYPPENVQAIATSPESISISWST 1111
Query: 531 -----FNGYVIDFNKENIHYQRNFMLDSNGEL-----LIRNAQLKHAGRYT-----CTAQ 575
NG + F + Y N M GE+ + +L +YT A
Sbjct: 1112 LSKEALNGILQGFR---VIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAF 1168
Query: 576 TIVDNSSASADLVVRGP---PGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKT 632
T + S + R PGPP G++ A+ V ++W + I KYT+
Sbjct: 1169 TRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSH 1228
Query: 633 ILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDG 692
+ + P + R +L +Y VVA + GRG S I +
Sbjct: 1229 PYPTVISEFEASPDSF-----SYRIPNLSRNRQYSVWVVAVTSAGRGNSS---EIITVEP 1280
Query: 693 AAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFK----PFDGEEWKKVTV 748
A AP+ + G +T W ++ K P +W K +
Sbjct: 1281 LAK--APARILTFSGT---VTTPWMK-----------DIVLPCKAVGDPSPAVKWMKDSN 1324
Query: 749 TNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVA---------VINSAQDAPSE 799
P + S + VKA + G YS +A ++N P +
Sbjct: 1325 GTPSLVTIDGRRSIFSNGSFIIRTVKA---EDSGYYSCIANNNWGSDEIILNLQVQVPPD 1381
Query: 800 APTEVGVKVLSSSEISVHWEHVLE--KIVESYQIRYWAAHDKEEAANRVQVTSQEYSARL 857
P + V +SS I++ W + Y ++Y + D E ++ E S RL
Sbjct: 1382 QP-RLTVSKTTSSSITLSWLPGDNGGSSIRGYILQY--SEDNSEQWGSFPISPSERSYRL 1438
Query: 858 ENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPP--SQPPRIISSVRSG--SRYIIT 913
ENL T Y + A N G G S++IEA T P S+ + +S+ + +I
Sbjct: 1439 ENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIG 1498
Query: 914 WDHVVALSNESTVTGYKVLYRPDG 937
W+ +T + + YRP G
Sbjct: 1499 WN-----DGGCPITSFTLEYRPFG 1517
Score = 55.8 bits (133), Expect = 2e-07
Identities = 67/286 (23%), Positives = 108/286 (37%), Gaps = 30/286 (10%)
Query: 421 VIIECKPKAAPKPKFSWSK---GTEWLVN-SSRILIWEDGSLEINNITRNDGGIYTCFAE 476
+++ CK P P W K GT LV R I+ +GS I + D G Y+C A
Sbjct: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIAN 1362
Query: 477 NNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVI 536
NN G L + P P +TV + + S+ P + S GY++
Sbjct: 1363 NNWGSDEIILNLQVQVP------PDQPRLTVSKTTSSSITLSWLPGDNGGS--SIRGYIL 1414
Query: 537 DFNKENIHYQRNFMLD-SNGELLIRNAQLKHAGRYTCTAQTIVDNSSAS----ADLVVRG 591
++++N +F + S + N + ++T TAQ V S A + +
Sbjct: 1415 QYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKE 1474
Query: 592 PPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAK----TDPPI 647
P I T V L +D PI+ +T++ + + W A+ + I
Sbjct: 1475 PQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYI 1534
Query: 648 IEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGA 693
+ EA W E + RV N+ G E + DG+
Sbjct: 1535 LYDLQEAT-------WYELQMRV--CNSAGCAEKQANFATLNYDGS 1571
Score = 52.8 bits (125), Expect = 2e-06
Identities = 73/322 (22%), Positives = 121/322 (37%), Gaps = 54/322 (16%)
Query: 303 NIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRW-LKNG---- 357
N+ +D H + +V A + V + T + PC A G P T+RW L G
Sbjct: 14 NVFSEDLHSSLYFVNASLQEVVFASTTGTLV------PCPAAGIPPVTLRWYLATGEEIY 67
Query: 358 ------YAYHKGELRLYDV------TFENAGMYQCIAENTYGAIYA-NAELKILALAP-T 403
+ + G L+++ T + Y C AEN G I + + +K + P T
Sbjct: 68 DVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYT 127
Query: 404 FEMNPMKKKILAAKGGRVIIECKPKAAPKPKF---SWSKGTEWLVNSSRILIWEDGSLEI 460
+ K +G + +C ++ + SW K T LV+ SR LI G+L I
Sbjct: 128 VRVEDQK----TMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYI 183
Query: 461 NNITRNDGGI-YTCFAEN---NRGKANSTGTLVITDPTR----IILAPINADITVGENAT 512
++ DG Y C + + +++ L ++DP I+ + G+
Sbjct: 184 KDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVE 243
Query: 513 MQCAASFDPALDLTFVWSFNGYVIDFNKEN--IHYQRNFMLDSNGELLIRNAQLKHAGRY 570
+ C A P D ++ K+N + F G LLI N + +G Y
Sbjct: 244 LPCKALGHPEPDYRWL-----------KDNMPLELSGRFQKTVTG-LLIENIRPSDSGSY 291
Query: 571 TCTAQTIVDNSSASADLVVRGP 592
C + L V+ P
Sbjct: 292 VCEVSNRYGTAKVIGRLYVKQP 313
>gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
Length = 613
Score = 219 bits (559), Expect = 8e-57
Identities = 174/571 (30%), Positives = 250/571 (43%), Gaps = 47/571 (8%)
Query: 50 VSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMV--GGNLVIN-----NPDKQKDAGIY 101
+ + C A+ +P P + W N+ ++ D R SM G LVI+ P++ + G Y
Sbjct: 53 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--GEY 110
Query: 102 YCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRW 161
C A N +G S L +P E V V+EG + L C+PP P + + W
Sbjct: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIF-W 169
Query: 162 LLNEFPVFITMDKRRFVSQT-NGNLYIANVEASD-KGNYSC-----FVSSPSITKSVFSK 214
+ + IT DKR VSQ NG+LY +NV D + +YSC F + K
Sbjct: 170 MSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLK 226
Query: 215 FIPLIPIPERTTK-PYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS 273
+ + ERT YP L G ++ LEC A G P PDI W K +PS
Sbjct: 227 VLTTRGVAERTPSFMYPQGTA---SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 283
Query: 274 T-AEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVD 332
A+ L+I N+ ED G Y C A N G +H + V+A P W++ + +
Sbjct: 284 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 343
Query: 333 IGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------GELRLY-DVTFENAGMYQCI 381
G D C A G P PT++W+ NG G+ ++ D + +YQC
Sbjct: 344 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 403
Query: 382 AENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK-G 440
N +G + ANA + +L + P ++P + I R ++C +P P W K G
Sbjct: 404 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 462
Query: 441 TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 500
++ ++E+GSLEI I + D GIYTC A N GKA + L + DPTRI P
Sbjct: 463 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 522
Query: 501 INADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIR 560
+ G ++C DP+L LT W + Y N M + L I
Sbjct: 523 EDQVARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEPLYIGNRMKKEDDSLTIF 574
Query: 561 NAQLKHAGRYTCTAQTIVDNSSASADLVVRG 591
+ G YTC A T +D A A L V G
Sbjct: 575 GVAERDQGSYTCVASTELDQDLAKAYLTVLG 605
Score = 83.6 bits (205), Expect = 9e-16
Identities = 88/365 (24%), Positives = 149/365 (40%), Gaps = 30/365 (8%)
Query: 52 LNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGM 111
L C A P P W GD+ ++ L I N ++ D+G Y+CLASN G
Sbjct: 260 LECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEE-DSGEYFCLASNKMGS 318
Query: 112 VRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPV-FI 170
+R T + P+ +E + + G+ L+C + + +W++N P+
Sbjct: 319 IRHTISVRVKAA--PYWLDEPKNLILAPGEDGRLVCRANGN--PKPTVQWMVNGEPLQSA 374
Query: 171 TMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYP 230
+ R V+ + + + S + Y C S+ + + F+ ++ +P R P
Sbjct: 375 PPNPNREVA--GDTIIFRDTQISSRAVYQCNTSNEH-GYLLANAFVSVLDVPPRMLSPRN 431
Query: 231 ADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMP---STAEISTSGAVLKIF 287
I V ++ L+C G+P+P +RW K + + +G+ L+I
Sbjct: 432 QLIRV-------ILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS-LEIK 483
Query: 288 NIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKP 347
I+ ED+GIY C A NI GK ++Q R+ V+ D G+ + C P
Sbjct: 484 MIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDP 543
Query: 348 IP--TIRWLKNGYAYHKGE--------LRLYDVTFENAGMYQCIAENTYGAIYANAELKI 397
T+ WLK+ + G L ++ V + G Y C+A A A L +
Sbjct: 544 SLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
Query: 398 LALAP 402
L P
Sbjct: 604 LGNCP 608
Score = 79.0 bits (193), Expect = 2e-14
Identities = 113/474 (23%), Positives = 180/474 (37%), Gaps = 63/474 (13%)
Query: 158 SYRWLLNEFPVFITMDKRRFVSQTNGNLYI----ANVEASDKGNYSCFVSSPSITKSVFS 213
S+ W N I D R + + +G L I +G Y CF + T S
Sbjct: 66 SFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT--ALS 123
Query: 214 KFIPL----IPI-PERTTKPYPADIVVQFKDVYALMGQNVTLECFAL-GNPVPDIRWRKV 267
I L P+ P+ P +VVQ G +TL+C G P P I W
Sbjct: 124 NRIRLQVSKSPLWPKENLDP----VVVQ-------EGAPLTLQCNPPPGLPSPVIFWMSS 172
Query: 268 -LEPMPSTAEISTS-GAVLKIFNIQLED-EGIYECEAE-----NIRGKDKHQARIYV--- 316
+EP+ +S L N+ L+D + Y C A I+ K+ ++
Sbjct: 173 SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 232
Query: 317 --QAFPEWVEHINDTEVDI---GSDLYWPCVATGKPIPTIRWLKNG---------YAYHK 362
+ P ++ + G DL C+A+G P P I W K G +
Sbjct: 233 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFN 292
Query: 363 GELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVI 422
LR+ +V+ E++G Y C+A N G+I +++ A AP + P + + GR++
Sbjct: 293 KALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA-APYWLDEPKNLILAPGEDGRLV 351
Query: 423 IECKPKAAPKPKFSWSKGTEWLV----NSSRILIWEDGSLEINNITRNDGGIYTCFAENN 478
C+ PKP W E L N +R + + ++ + + +Y C N
Sbjct: 352 --CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGD--TIIFRDTQISSRAVYQCNTSNE 407
Query: 479 RGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDF 538
G + + + D +L+P N I V + F + T W NG +
Sbjct: 408 HGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL 467
Query: 539 NKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGP 592
+ N H N G L I+ + + G YTC A I+ + L V+ P
Sbjct: 468 DGGNYHVYEN------GSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 515
Score = 76.6 bits (187), Expect = 1e-13
Identities = 91/386 (23%), Positives = 142/386 (36%), Gaps = 40/386 (10%)
Query: 219 IPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPS 273
I IP T+P P KD N+ +EC A GNP P W + + P
Sbjct: 25 IEIPMDLTQP-PTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR 83
Query: 274 TAEISTSGAVLKIFNI---QLEDEGIYECEAENIRGKD-KHQARIYVQAFPEW-VEHIND 328
+ SG ++ F E EG Y+C A N G ++ R+ V P W E+++
Sbjct: 84 VSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 143
Query: 329 TEVDIGSDLYWPC-VATGKPIPTIRWL----------KNGYAYHKGELRLYDVTFENAGM 377
V G+ L C G P P I W+ K H G+L +V ++
Sbjct: 144 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT 203
Query: 378 -YQCIAENTYGAIYANAE---LKILALAPTFEMNP-------MKKKILAAKGGRVIIECK 426
Y C A + LK+L E P + +G +++EC
Sbjct: 204 DYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECI 263
Query: 427 PKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTG 486
P P +W K L + + +L I N++ D G Y C A N G T
Sbjct: 264 ASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTI 323
Query: 487 TLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQ 546
++ + + P N + GE+ + C A+ +P T W NG + N + +
Sbjct: 324 SVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNRE 381
Query: 547 RNFMLDSNGELLIRNAQLKHAGRYTC 572
+ ++ R+ Q+ Y C
Sbjct: 382 -----VAGDTIIFRDTQISSRAVYQC 402
Score = 50.8 bits (120), Expect = 6e-06
Identities = 40/160 (25%), Positives = 69/160 (43%), Gaps = 8/160 (5%)
Query: 46 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 105
L + L+C SP P +W N +L Y + + +++D GIY C+A
Sbjct: 438 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 497
Query: 106 SNNYGMVRSTEATLSFGYLDPFPPEERPEVRV-KEGKGMVLLCDPPYHFPDDLSYRWLLN 164
+N G E + DP PE +V + G + L C + L+ WL +
Sbjct: 498 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 554
Query: 165 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 204
+ P++I + + + +L I V D+G+Y+C S+
Sbjct: 555 DEPLYI----GNRMKKEDDSLTIFGVAERDQGSYTCVAST 590
>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
Length = 619
Score = 219 bits (559), Expect = 8e-57
Identities = 174/571 (30%), Positives = 250/571 (43%), Gaps = 47/571 (8%)
Query: 50 VSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMV--GGNLVIN-----NPDKQKDAGIY 101
+ + C A+ +P P + W N+ ++ D R SM G LVI+ P++ + G Y
Sbjct: 59 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--GEY 116
Query: 102 YCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRW 161
C A N +G S L +P E V V+EG + L C+PP P + + W
Sbjct: 117 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIF-W 175
Query: 162 LLNEFPVFITMDKRRFVSQT-NGNLYIANVEASD-KGNYSC-----FVSSPSITKSVFSK 214
+ + IT DKR VSQ NG+LY +NV D + +YSC F + K
Sbjct: 176 MSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLK 232
Query: 215 FIPLIPIPERTTK-PYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS 273
+ + ERT YP L G ++ LEC A G P PDI W K +PS
Sbjct: 233 VLTTRGVAERTPSFMYPQGTA---SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 289
Query: 274 T-AEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVD 332
A+ L+I N+ ED G Y C A N G +H + V+A P W++ + +
Sbjct: 290 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 349
Query: 333 IGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------GELRLY-DVTFENAGMYQCI 381
G D C A G P PT++W+ NG G+ ++ D + +YQC
Sbjct: 350 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 409
Query: 382 AENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK-G 440
N +G + ANA + +L + P ++P + I R ++C +P P W K G
Sbjct: 410 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 468
Query: 441 TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 500
++ ++E+GSLEI I + D GIYTC A N GKA + L + DPTRI P
Sbjct: 469 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 528
Query: 501 INADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIR 560
+ G ++C DP+L LT W + Y N M + L I
Sbjct: 529 EDQVARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEPLYIGNRMKKEDDSLTIF 580
Query: 561 NAQLKHAGRYTCTAQTIVDNSSASADLVVRG 591
+ G YTC A T +D A A L V G
Sbjct: 581 GVAERDQGSYTCVASTELDQDLAKAYLTVLG 611
Score = 83.6 bits (205), Expect = 9e-16
Identities = 88/365 (24%), Positives = 149/365 (40%), Gaps = 30/365 (8%)
Query: 52 LNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGM 111
L C A P P W GD+ ++ L I N ++ D+G Y+CLASN G
Sbjct: 266 LECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEE-DSGEYFCLASNKMGS 324
Query: 112 VRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPV-FI 170
+R T + P+ +E + + G+ L+C + + +W++N P+
Sbjct: 325 IRHTISVRVKAA--PYWLDEPKNLILAPGEDGRLVCRANGN--PKPTVQWMVNGEPLQSA 380
Query: 171 TMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYP 230
+ R V+ + + + S + Y C S+ + + F+ ++ +P R P
Sbjct: 381 PPNPNREVA--GDTIIFRDTQISSRAVYQCNTSNEH-GYLLANAFVSVLDVPPRMLSPRN 437
Query: 231 ADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMP---STAEISTSGAVLKIF 287
I V ++ L+C G+P+P +RW K + + +G+ L+I
Sbjct: 438 QLIRV-------ILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS-LEIK 489
Query: 288 NIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKP 347
I+ ED+GIY C A NI GK ++Q R+ V+ D G+ + C P
Sbjct: 490 MIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDP 549
Query: 348 IP--TIRWLKNGYAYHKGE--------LRLYDVTFENAGMYQCIAENTYGAIYANAELKI 397
T+ WLK+ + G L ++ V + G Y C+A A A L +
Sbjct: 550 SLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
Query: 398 LALAP 402
L P
Sbjct: 610 LGNCP 614
Score = 79.0 bits (193), Expect = 2e-14
Identities = 113/474 (23%), Positives = 180/474 (37%), Gaps = 63/474 (13%)
Query: 158 SYRWLLNEFPVFITMDKRRFVSQTNGNLYI----ANVEASDKGNYSCFVSSPSITKSVFS 213
S+ W N I D R + + +G L I +G Y CF + T S
Sbjct: 72 SFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT--ALS 129
Query: 214 KFIPL----IPI-PERTTKPYPADIVVQFKDVYALMGQNVTLECFAL-GNPVPDIRWRKV 267
I L P+ P+ P +VVQ G +TL+C G P P I W
Sbjct: 130 NRIRLQVSKSPLWPKENLDP----VVVQ-------EGAPLTLQCNPPPGLPSPVIFWMSS 178
Query: 268 -LEPMPSTAEISTS-GAVLKIFNIQLED-EGIYECEAE-----NIRGKDKHQARIYV--- 316
+EP+ +S L N+ L+D + Y C A I+ K+ ++
Sbjct: 179 SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 238
Query: 317 --QAFPEWVEHINDTEVDI---GSDLYWPCVATGKPIPTIRWLKNG---------YAYHK 362
+ P ++ + G DL C+A+G P P I W K G +
Sbjct: 239 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFN 298
Query: 363 GELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVI 422
LR+ +V+ E++G Y C+A N G+I +++ A AP + P + + GR++
Sbjct: 299 KALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA-APYWLDEPKNLILAPGEDGRLV 357
Query: 423 IECKPKAAPKPKFSWSKGTEWLV----NSSRILIWEDGSLEINNITRNDGGIYTCFAENN 478
C+ PKP W E L N +R + + ++ + + +Y C N
Sbjct: 358 --CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGD--TIIFRDTQISSRAVYQCNTSNE 413
Query: 479 RGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDF 538
G + + + D +L+P N I V + F + T W NG +
Sbjct: 414 HGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL 473
Query: 539 NKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGP 592
+ N H N G L I+ + + G YTC A I+ + L V+ P
Sbjct: 474 DGGNYHVYEN------GSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 521
Score = 76.3 bits (186), Expect = 1e-13
Identities = 89/383 (23%), Positives = 141/383 (36%), Gaps = 46/383 (12%)
Query: 222 PERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPSTAE 276
P TK D +V +D N+ +EC A GNP P W + + P +
Sbjct: 40 PPTITKQSAKDHIVDPRD-------NILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 92
Query: 277 ISTSGAVLKIFNI---QLEDEGIYECEAENIRGKD-KHQARIYVQAFPEW-VEHINDTEV 331
SG ++ F E EG Y+C A N G ++ R+ V P W E+++ V
Sbjct: 93 RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVV 152
Query: 332 DIGSDLYWPC-VATGKPIPTIRWL----------KNGYAYHKGELRLYDVTFENAGM-YQ 379
G+ L C G P P I W+ K H G+L +V ++ Y
Sbjct: 153 QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 212
Query: 380 CIAENTYGAIYANAE---LKILALAPTFEMNP-------MKKKILAAKGGRVIIECKPKA 429
C A + LK+L E P + +G +++EC
Sbjct: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 272
Query: 430 APKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLV 489
P P +W K L + + +L I N++ D G Y C A N G T ++
Sbjct: 273 VPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 332
Query: 490 ITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNF 549
+ + P N + GE+ + C A+ +P T W NG + N + +
Sbjct: 333 VKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNRE--- 387
Query: 550 MLDSNGELLIRNAQLKHAGRYTC 572
+ ++ R+ Q+ Y C
Sbjct: 388 --VAGDTIIFRDTQISSRAVYQC 408
Score = 50.8 bits (120), Expect = 6e-06
Identities = 40/160 (25%), Positives = 69/160 (43%), Gaps = 8/160 (5%)
Query: 46 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 105
L + L+C SP P +W N +L Y + + +++D GIY C+A
Sbjct: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503
Query: 106 SNNYGMVRSTEATLSFGYLDPFPPEERPEVRV-KEGKGMVLLCDPPYHFPDDLSYRWLLN 164
+N G E + DP PE +V + G + L C + L+ WL +
Sbjct: 504 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560
Query: 165 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 204
+ P++I + + + +L I V D+G+Y+C S+
Sbjct: 561 DEPLYI----GNRMKKEDDSLTIFGVAERDQGSYTCVAST 596
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
1 precursor [Homo sapiens]
Length = 1907
Score = 201 bits (512), Expect = 2e-51
Identities = 185/672 (27%), Positives = 294/672 (43%), Gaps = 70/672 (10%)
Query: 341 CVATGKPIPTIRWLKNGYAYHKGELRLYDVTFENAG---------------MYQCIAENT 385
C ATG+P P I W+K G + + + AG +Y+C A N+
Sbjct: 54 CQATGEPKPRITWMKKGKKVSSQRFEVIEFD-DGAGSVLRIQPLRVQRDEAIYECTATNS 112
Query: 386 YGAIYANAELKILALA------PTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK 439
G I +A+L +L P+ +M P K + A+ ++ C P P+ SW K
Sbjct: 113 LGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATML--CAAGGNPDPEISWFK 170
Query: 440 G---TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRI 496
+ ++ RI G+L+I + +D G Y C A N+ G S + R+
Sbjct: 171 DFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRV 230
Query: 497 I----LAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLD 552
+ P + ++ G + + C A P + +V G ++ + RN +
Sbjct: 231 APRFSIPPSSQEVMPGGSVNLTCVAVGAP---MPYVKWMMGAEELTKEDEMPVGRNVLEL 287
Query: 553 SNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALT 612
SN ++R+A YTC A + + A+A + V+ P PP L + + ATSV LT
Sbjct: 288 SN---VVRSAN------YTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLT 338
Query: 613 WSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVD---LIPWMEYEFR 669
W G N P++ Y IQ ++ A T+ P E + A L P+ EY FR
Sbjct: 339 WDSG--NSEPVTYYGIQ--------YRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFR 388
Query: 670 VVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNF 729
V+A N++GRG PS + R +T AP+ P V + + W P E G
Sbjct: 389 VLAVNSIGRGPPS-EAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP--PEEPNGLVR 445
Query: 730 GYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAV 789
GY V + P N D G + ++ P + ++V AF GDGP S
Sbjct: 446 GYRVYYTPDSRRPPNAWHKHNTDAG-LLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQ 504
Query: 790 INSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANRVQVT 849
+ + Q P++ P + +V S + I + W ++ + Y++ YWAA D+++
Sbjct: 505 VKTQQGVPAQ-PADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDP 563
Query: 850 SQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSR 909
+ Y+ LE+L PDT Y ++ A + G G + IEA T ++ PS PP+ + V GS
Sbjct: 564 TSSYT--LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGST 621
Query: 910 YI-ITWDHVVALSNESTVTGYKVLYRP-DGQHDGK-----LYSTHKHSIEVPIPRDGEYV 962
+ ++W A S +T Y V Y DG+ G+ + H V + + EY
Sbjct: 622 TVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYR 681
Query: 963 VEVRAHSDGGDG 974
V VRAH+D G G
Sbjct: 682 VWVRAHTDVGPG 693
Score = 112 bits (280), Expect = 2e-24
Identities = 145/592 (24%), Positives = 236/592 (39%), Gaps = 80/592 (13%)
Query: 418 GGRVIIECKPKAAPKPKFSW-SKGTEWLVNSSRILIWEDGSLEINNI----TRNDGGIYT 472
GG C+ PKP+ +W KG + ++ ++DG+ + I + D IY
Sbjct: 47 GGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYE 106
Query: 473 CFAENNRGKANSTGTLVITDPTR-------IILAPINADITVGENATMQCAASFDPALDL 525
C A N+ G+ N++ L + + + I + P + ATM CAA +P D
Sbjct: 107 CTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNP--DP 164
Query: 526 TFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNS-SAS 584
W + +D N ++ +G L I +++ G+Y C A SA
Sbjct: 165 EISWFKDFLPVDPATSNGRIKQL----RSGALQIESSEESDQGKYECVATNSAGTRYSAP 220
Query: 585 ADLVVRG---------PPGP----PGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTK 631
A+L VR PP PGG + T VA+ P K+ + +
Sbjct: 221 ANLYVRVRRVAPRFSIPPSSQEVMPGG----SVNLTCVAV------GAPMPYVKWMMGAE 270
Query: 632 TILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTD 691
+ +D + P+ +E + V + VA ++LG I + T
Sbjct: 271 ELTKED------EMPVGRNVLELSNVV-----RSANYTCVAISSLG----MIEATAQVTV 315
Query: 692 GAAPNVAPSDVGGGGGRNRELTITWAPLSRE--YHYGNNFGYIVAFKPFDGEEWKKVTVT 749
A P P D+ +T+TW + E +YG + PF +E V T
Sbjct: 316 KALPK-PPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPF--QEVDGVATT 372
Query: 750 NPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVL 809
G +SP + + +V A N+ G GP S + + APS P V ++L
Sbjct: 373 RYSIG-------GLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARML 425
Query: 810 SSSEISVHWEHVLEK--IVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYF 867
S+S + V WE E +V Y++ Y + A T + +LLP Y
Sbjct: 426 SASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYS 485
Query: 868 IEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVT 927
+ V A + G GPPS I+ T++ P+QP + V S +R ++W L + +
Sbjct: 486 LRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSW----LLPPQERII 541
Query: 928 GYKVLY----RPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGV 975
Y+++Y D QH T +++E + D Y ++ A SD G GV
Sbjct: 542 MYELVYWAAEDEDQQHKVTFDPTSSYTLE-DLKPDTLYRFQLAARSDMGVGV 592
Score = 82.4 bits (202), Expect = 2e-15
Identities = 100/438 (22%), Positives = 170/438 (38%), Gaps = 48/438 (10%)
Query: 590 RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIE 649
+G P P + E T + L+W I Y + +D + T P
Sbjct: 509 QGVPAQPADFQAEVESDTRIQLSWLLPPQER--IIMYELVYWAAEDEDQQHKVTFDPTSS 566
Query: 650 GNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRN 709
+E DL P Y F++ A + +G G + P+ +T + P+ P V +
Sbjct: 567 YTLE-----DLKPDTLYRFQLAARSDMGVGVFT-PTIEARTAQSTPSAPPQKVMCVSMGS 620
Query: 710 RELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAF 769
+ ++W P + G Y VA++ DGE+ + V + T +
Sbjct: 621 TTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEY 680
Query: 770 QVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEK----I 825
+V V+A + G GP S ++ + +D PS P +V V+ L+S+ + V+W+ +
Sbjct: 681 RVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQ 740
Query: 826 VESYQIRYWAAHDKE-------------EAANRVQVTSQEYSARLENLLPDTQYFIEVGA 872
+ YQ+ Y + E EA R + S++Y + L P+T Y + V A
Sbjct: 741 IRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPE-ESEDYETTISGLTPETTYSVTVAA 799
Query: 873 CNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVL 932
+ G G S T A P +P +IS+ + ++ W L E + GY++
Sbjct: 800 YTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTA-LLQWHPPKELPGE--LLGYRLQ 856
Query: 933 Y------RPD----GQHDGKLYSTHKHSIEVPIPR---------DGEYVVEVRAHSDGGD 973
Y RP+ G+ D T H I R E+ E+R D
Sbjct: 857 YCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPS 916
Query: 974 GVVSQVKISGAPTLSPSL 991
G + ++G T + L
Sbjct: 917 GFPQNLHVTGLTTSTTEL 934
Score = 74.7 bits (182), Expect = 4e-13
Identities = 75/306 (24%), Positives = 132/306 (43%), Gaps = 32/306 (10%)
Query: 33 EEQPINTIYPEESLE---GKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMV------ 83
+ +P+ PE+ G S C+A P P W V +S R+ ++
Sbjct: 30 DSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKV--SSQRFEVIEFDDGA 87
Query: 84 GGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPP-----EERPEVRVK 138
G L I Q+D IY C A+N+ G + +T A LS + PP + P+++V
Sbjct: 88 GSVLRIQPLRVQRDEAIYECTATNSLGEI-NTSAKLSVLEEEQLPPGFPSIDMGPQLKVV 146
Query: 139 E-GKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGN 197
E + +LC + ++S W + PV R +G L I + E SD+G
Sbjct: 147 EKARTATMLCAAGGNPDPEIS--WFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGK 204
Query: 198 YSCFVSSPSITK--SVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFAL 255
Y C ++ + T+ + + ++ + + R + P + V+ G +V L C A+
Sbjct: 205 YECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMP--------GGSVNLTCVAV 256
Query: 256 GNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIY 315
G P+P ++W E + E+ VL++ N+ Y C A + G + A++
Sbjct: 257 GAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSAN--YTCVAISSLGMIEATAQVT 314
Query: 316 VQAFPE 321
V+A P+
Sbjct: 315 VKALPK 320
Score = 62.8 bits (151), Expect = 2e-09
Identities = 53/172 (30%), Positives = 81/172 (47%), Gaps = 20/172 (11%)
Query: 246 QNVTLECFALGNPVPDIRWRK---VLEPMPSTAEIST--SGAVLKIFNIQLEDEGIYECE 300
+ T+ C A GNP P+I W K ++P S I SGA L+I + + D+G YEC
Sbjct: 150 RTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGA-LQIESSEESDQGKYECV 208
Query: 301 AENIRG-KDKHQARIYVQA---FPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKN 356
A N G + A +YV+ P + + EV G + CVA G P+P ++W+
Sbjct: 209 ATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMG 268
Query: 357 GYAYHKGE--------LRLYDVTFENAGMYQCIAENTYGAIYANAELKILAL 400
K + L L +V + Y C+A ++ G I A A++ + AL
Sbjct: 269 AEELTKEDEMPVGRNVLELSNVV--RSANYTCVAISSLGMIEATAQVTVKAL 318
Score = 58.9 bits (141), Expect = 2e-08
Identities = 104/443 (23%), Positives = 165/443 (37%), Gaps = 54/443 (12%)
Query: 574 AQTIVDNSSASADLVVRG----PPGPPGGLRIEDIRATSVALTWSRG--SDNHSPISKYT 627
A T V S+ ++VR P GPP + +E + +T+V + W S H I Y
Sbjct: 686 AHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQ 745
Query: 628 IQTKTILSDDWKDAKT--DPPIIEGNMEAARAVD-------LIPWMEYEFRVVATNTLGR 678
+ + + + + D + E + D L P Y V A T G
Sbjct: 746 VTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGD 805
Query: 679 GEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPF 738
G S P + T GA P P+ + N L + W P +E G GY + +
Sbjct: 806 GARSKPKI-VTTTGAVPG-RPTMMISTTAMNTAL-LQWHP-PKELP-GELLGYRLQYCRA 860
Query: 739 D---------GEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAV 789
D G++ + TVT +HK T + ++ A N G G
Sbjct: 861 DEARPNTIDFGKDDQHFTVTG------LHK------GTTYIFRLAAKNRAGLGE-EFEKE 907
Query: 790 INSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANRVQVT 849
I + +D PS P + V L++S + W+ + I Y + +Q
Sbjct: 908 IRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNI 967
Query: 850 SQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSR 909
+ + L L PDT Y I+V A S G GP S I++ T + +
Sbjct: 968 TTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTS 1027
Query: 910 YIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIE---VPIPRDGEYVVEVR 966
+++W+ V S +S V +K+LY +G+ HS+ + + EY +
Sbjct: 1028 VLLSWE--VPDSYKSAVP-FKILY------NGQSVEVDGHSMRKLIADLQPNTEYSFVLM 1078
Query: 967 AHSDGGDGVVSQVKISGAPTLSP 989
G+ V I AP L P
Sbjct: 1079 NRGSSAGGLQHLVSIRTAPDLLP 1101
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform
2 precursor [Homo sapiens]
Length = 1898
Score = 201 bits (512), Expect = 2e-51
Identities = 185/672 (27%), Positives = 294/672 (43%), Gaps = 70/672 (10%)
Query: 341 CVATGKPIPTIRWLKNGYAYHKGELRLYDVTFENAG---------------MYQCIAENT 385
C ATG+P P I W+K G + + + AG +Y+C A N+
Sbjct: 54 CQATGEPKPRITWMKKGKKVSSQRFEVIEFD-DGAGSVLRIQPLRVQRDEAIYECTATNS 112
Query: 386 YGAIYANAELKILALA------PTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK 439
G I +A+L +L P+ +M P K + A+ ++ C P P+ SW K
Sbjct: 113 LGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATML--CAAGGNPDPEISWFK 170
Query: 440 G---TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRI 496
+ ++ RI G+L+I + +D G Y C A N+ G S + R+
Sbjct: 171 DFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRV 230
Query: 497 I----LAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLD 552
+ P + ++ G + + C A P + +V G ++ + RN +
Sbjct: 231 APRFSIPPSSQEVMPGGSVNLTCVAVGAP---MPYVKWMMGAEELTKEDEMPVGRNVLEL 287
Query: 553 SNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALT 612
SN ++R+A YTC A + + A+A + V+ P PP L + + ATSV LT
Sbjct: 288 SN---VVRSAN------YTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLT 338
Query: 613 WSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVD---LIPWMEYEFR 669
W G N P++ Y IQ ++ A T+ P E + A L P+ EY FR
Sbjct: 339 WDSG--NSEPVTYYGIQ--------YRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFR 388
Query: 670 VVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNF 729
V+A N++GRG PS + R +T AP+ P V + + W P E G
Sbjct: 389 VLAVNSIGRGPPS-EAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP--PEEPNGLVR 445
Query: 730 GYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAV 789
GY V + P N D G + ++ P + ++V AF GDGP S
Sbjct: 446 GYRVYYTPDSRRPPNAWHKHNTDAG-LLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQ 504
Query: 790 INSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANRVQVT 849
+ + Q P++ P + +V S + I + W ++ + Y++ YWAA D+++
Sbjct: 505 VKTQQGVPAQ-PADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDP 563
Query: 850 SQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSR 909
+ Y+ LE+L PDT Y ++ A + G G + IEA T ++ PS PP+ + V GS
Sbjct: 564 TSSYT--LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGST 621
Query: 910 YI-ITWDHVVALSNESTVTGYKVLYRP-DGQHDGK-----LYSTHKHSIEVPIPRDGEYV 962
+ ++W A S +T Y V Y DG+ G+ + H V + + EY
Sbjct: 622 TVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYR 681
Query: 963 VEVRAHSDGGDG 974
V VRAH+D G G
Sbjct: 682 VWVRAHTDVGPG 693
Score = 112 bits (280), Expect = 2e-24
Identities = 145/592 (24%), Positives = 236/592 (39%), Gaps = 80/592 (13%)
Query: 418 GGRVIIECKPKAAPKPKFSW-SKGTEWLVNSSRILIWEDGSLEINNI----TRNDGGIYT 472
GG C+ PKP+ +W KG + ++ ++DG+ + I + D IY
Sbjct: 47 GGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYE 106
Query: 473 CFAENNRGKANSTGTLVITDPTR-------IILAPINADITVGENATMQCAASFDPALDL 525
C A N+ G+ N++ L + + + I + P + ATM CAA +P D
Sbjct: 107 CTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNP--DP 164
Query: 526 TFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNS-SAS 584
W + +D N ++ +G L I +++ G+Y C A SA
Sbjct: 165 EISWFKDFLPVDPATSNGRIKQL----RSGALQIESSEESDQGKYECVATNSAGTRYSAP 220
Query: 585 ADLVVRG---------PPGP----PGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTK 631
A+L VR PP PGG + T VA+ P K+ + +
Sbjct: 221 ANLYVRVRRVAPRFSIPPSSQEVMPGG----SVNLTCVAV------GAPMPYVKWMMGAE 270
Query: 632 TILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTD 691
+ +D + P+ +E + V + VA ++LG I + T
Sbjct: 271 ELTKED------EMPVGRNVLELSNVV-----RSANYTCVAISSLG----MIEATAQVTV 315
Query: 692 GAAPNVAPSDVGGGGGRNRELTITWAPLSRE--YHYGNNFGYIVAFKPFDGEEWKKVTVT 749
A P P D+ +T+TW + E +YG + PF +E V T
Sbjct: 316 KALPK-PPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPF--QEVDGVATT 372
Query: 750 NPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVL 809
G +SP + + +V A N+ G GP S + + APS P V ++L
Sbjct: 373 RYSIG-------GLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARML 425
Query: 810 SSSEISVHWEHVLEK--IVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYF 867
S+S + V WE E +V Y++ Y + A T + +LLP Y
Sbjct: 426 SASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYS 485
Query: 868 IEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVT 927
+ V A + G GPPS I+ T++ P+QP + V S +R ++W L + +
Sbjct: 486 LRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSW----LLPPQERII 541
Query: 928 GYKVLY----RPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGV 975
Y+++Y D QH T +++E + D Y ++ A SD G GV
Sbjct: 542 MYELVYWAAEDEDQQHKVTFDPTSSYTLE-DLKPDTLYRFQLAARSDMGVGV 592
Score = 80.1 bits (196), Expect = 1e-14
Identities = 95/428 (22%), Positives = 166/428 (38%), Gaps = 37/428 (8%)
Query: 590 RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIE 649
+G P P + E T + L+W I Y + +D + T P
Sbjct: 509 QGVPAQPADFQAEVESDTRIQLSWLLPPQER--IIMYELVYWAAEDEDQQHKVTFDPTSS 566
Query: 650 GNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRN 709
+E DL P Y F++ A + +G G + P+ +T + P+ P V +
Sbjct: 567 YTLE-----DLKPDTLYRFQLAARSDMGVGVFT-PTIEARTAQSTPSAPPQKVMCVSMGS 620
Query: 710 RELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAF 769
+ ++W P + G Y VA++ DGE+ + V + T +
Sbjct: 621 TTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEY 680
Query: 770 QVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEK----I 825
+V V+A + G GP S ++ + +D PS P +V V+ L+S+ + V+W+ +
Sbjct: 681 RVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQ 740
Query: 826 VESYQIRYWAAHDKEEAANRV---QVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPS 882
+ YQ+ Y + E + + ++ + L P+T Y + V A + G G S
Sbjct: 741 IRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARS 800
Query: 883 DMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLY------RPD 936
T A P +P +IS+ + ++ W L E + GY++ Y RP+
Sbjct: 801 KPKIVTTTGAVPGRPTMMISTTAMNTA-LLQWHPPKELPGE--LLGYRLQYCRADEARPN 857
Query: 937 ----GQHDGKLYSTHKHSIEVPIPR---------DGEYVVEVRAHSDGGDGVVSQVKISG 983
G+ D T H I R E+ E+R D G + ++G
Sbjct: 858 TIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTG 917
Query: 984 APTLSPSL 991
T + L
Sbjct: 918 LTTSTTEL 925
Score = 74.7 bits (182), Expect = 4e-13
Identities = 75/306 (24%), Positives = 132/306 (43%), Gaps = 32/306 (10%)
Query: 33 EEQPINTIYPEESLE---GKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMV------ 83
+ +P+ PE+ G S C+A P P W V +S R+ ++
Sbjct: 30 DSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKV--SSQRFEVIEFDDGA 87
Query: 84 GGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPP-----EERPEVRVK 138
G L I Q+D IY C A+N+ G + +T A LS + PP + P+++V
Sbjct: 88 GSVLRIQPLRVQRDEAIYECTATNSLGEI-NTSAKLSVLEEEQLPPGFPSIDMGPQLKVV 146
Query: 139 E-GKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGN 197
E + +LC + ++S W + PV R +G L I + E SD+G
Sbjct: 147 EKARTATMLCAAGGNPDPEIS--WFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGK 204
Query: 198 YSCFVSSPSITK--SVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFAL 255
Y C ++ + T+ + + ++ + + R + P + V+ G +V L C A+
Sbjct: 205 YECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMP--------GGSVNLTCVAV 256
Query: 256 GNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIY 315
G P+P ++W E + E+ VL++ N+ Y C A + G + A++
Sbjct: 257 GAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSAN--YTCVAISSLGMIEATAQVT 314
Query: 316 VQAFPE 321
V+A P+
Sbjct: 315 VKALPK 320
Score = 63.5 bits (153), Expect = 9e-10
Identities = 101/434 (23%), Positives = 163/434 (37%), Gaps = 45/434 (10%)
Query: 574 AQTIVDNSSASADLVVRG----PPGPPGGLRIEDIRATSVALTWSRG--SDNHSPISKYT 627
A T V S+ ++VR P GPP + +E + +T+V + W S H I Y
Sbjct: 686 AHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQ 745
Query: 628 IQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNR 687
+ + + + + ++ + L P Y V A T G G S P
Sbjct: 746 VTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKI- 804
Query: 688 IKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFD-------- 739
+ T GA P P+ + N L + W P +E G GY + + D
Sbjct: 805 VTTTGAVPG-RPTMMISTTAMNTAL-LQWHP-PKELP-GELLGYRLQYCRADEARPNTID 860
Query: 740 -GEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPS 798
G++ + TVT +HK T + ++ A N G G I + +D PS
Sbjct: 861 FGKDDQHFTVTG------LHK------GTTYIFRLAAKNRAGLGE-EFEKEIRTPEDLPS 907
Query: 799 EAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQEYSARLE 858
P + V L++S + W+ + I Y + +Q + + L
Sbjct: 908 GFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLT 967
Query: 859 NLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVV 918
L PDT Y I+V A S G GP S I++ T + + +++W+ V
Sbjct: 968 GLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWE--V 1025
Query: 919 ALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIE---VPIPRDGEYVVEVRAHSDGGDGV 975
S +S V +K+LY +G+ HS+ + + EY + G+
Sbjct: 1026 PDSYKSAVP-FKILY------NGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGL 1078
Query: 976 VSQVKISGAPTLSP 989
V I AP L P
Sbjct: 1079 QHLVSIRTAPDLLP 1092
Score = 62.8 bits (151), Expect = 2e-09
Identities = 53/172 (30%), Positives = 81/172 (47%), Gaps = 20/172 (11%)
Query: 246 QNVTLECFALGNPVPDIRWRK---VLEPMPSTAEIST--SGAVLKIFNIQLEDEGIYECE 300
+ T+ C A GNP P+I W K ++P S I SGA L+I + + D+G YEC
Sbjct: 150 RTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGA-LQIESSEESDQGKYECV 208
Query: 301 AENIRG-KDKHQARIYVQA---FPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKN 356
A N G + A +YV+ P + + EV G + CVA G P+P ++W+
Sbjct: 209 ATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMG 268
Query: 357 GYAYHKGE--------LRLYDVTFENAGMYQCIAENTYGAIYANAELKILAL 400
K + L L +V + Y C+A ++ G I A A++ + AL
Sbjct: 269 AEELTKEDEMPVGRNVLELSNVV--RSANYTCVAISSLGMIEATAQVTVKAL 318
>gi|28373124 contactin 4 isoform b precursor [Homo sapiens]
Length = 282
Score = 198 bits (504), Expect = 2e-50
Identities = 97/239 (40%), Positives = 145/239 (60%), Gaps = 3/239 (1%)
Query: 743 WKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPT 802
W + + D RYV ++E++ P + F+VKV FNNKG+GP+S V+ SA++ P++ P
Sbjct: 3 WMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPA 62
Query: 803 EVGVKVLSSSEISVHWEHVLEKI---VESYQIRYWAAHDKEEAANRVQVTSQEYSARLEN 859
+ + LS+++I V W LEK ++ Y+++YW DKEE A +++ + S ++ N
Sbjct: 63 SIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITN 122
Query: 860 LLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVA 919
L Y + V A NSAG GP S + T+K PPSQPP I S S+ I+ WD V A
Sbjct: 123 LKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKA 182
Query: 920 LSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQ 978
L NES V GYKVLYR + Q + T+K S+E+ +P D +Y++E++ SDGGDG S+
Sbjct: 183 LDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSE 241
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 197 bits (502), Expect = 3e-50
Identities = 218/912 (23%), Positives = 358/912 (39%), Gaps = 79/912 (8%)
Query: 50 VSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVG---GNLVINNPDKQKDAGIYYCLAS 106
V L+C SP +W N ++ L + S+ G L+I + K +G Y C A+
Sbjct: 392 VILSCALTGSPEFTIRWYRNT-ELVLPDEAISIRGLSNETLLITSAQKSH-SGAYQCFAT 449
Query: 107 NNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEF 166
A ++ P E V G+ L+C P ++ W L++
Sbjct: 450 RK-AQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVT--WALDDE 506
Query: 167 PVF---------ITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIP 217
P+ TM +S N + + D G Y C + +
Sbjct: 507 PIVRDGSHRTNQYTMSDGTTISHMN----VTGPQIRDGGVYRCTARN----------LVG 552
Query: 218 LIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPST-AE 276
R P I +++ A+ G++ + C +G P I+W K +P +
Sbjct: 553 SAEYQARINVRGPPSIRAM-RNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQ 611
Query: 277 ISTSGAVLKIFNIQLE-DEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGS 335
+ LK+ ++Q DEG Y C Q+ P ++ IG
Sbjct: 612 VVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQ 671
Query: 336 DLYWPCVATGKPIPT-IRWLKNGYAYHKGE------------LRLYDVTFENAGMYQCIA 382
LY PCV + +P I W K+G G L++ V+ ++ G Y CIA
Sbjct: 672 LLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIA 731
Query: 383 ENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSW--SKG 440
N + +L I+ + P F + P + + K G ++ C P PK W +KG
Sbjct: 732 SNAAATVSRERQL-IVRVPPRFVVQPNNQDGIYGKAG--VLNCSVDGYPPPKVMWKHAKG 788
Query: 441 T------EWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPT 494
+ + + RI I + SL I ++ D G Y C A N G S +
Sbjct: 789 SGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIP 848
Query: 495 RIILAPINADITV-GENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDS 553
+I + N I + G + C A + + + W VID ++ +
Sbjct: 849 AMITSHPNTTIAIKGHAKELNCTARGERPIIIR--WEKGDTVIDPDRV---MRYAIATKD 903
Query: 554 NGELLIRNAQLKHAGR-----YTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATS 608
NG+ ++ +LK A R ++C A L V+ PP PP L I +++A S
Sbjct: 904 NGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPE-LEIREVKARS 962
Query: 609 VALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEF 668
+ L W++ D +S I+ + I+ K SD W D K I + A VDL P Y
Sbjct: 963 MNLRWTQRFDGNSIITGFDIEYKN-KSDSW-DFKQSTRNISPTINQANIVDLHPASVYSI 1020
Query: 669 RVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNN 728
R+ + N +GR EPS I T+ AAP+ P DV ++ + +TW +E G
Sbjct: 1021 RMYSFNKIGRSEPS-KELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVI 1079
Query: 729 FGYIVAFKPFD-GEEWKKVTVTNPDTG-RYVHKDETMSPSTAFQVKVKAFNNKGDGPYSL 786
GY + ++ G + V TG V+ + + + V V+AFN G GP S
Sbjct: 1080 RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSS 1139
Query: 787 VAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEH----VLEKIVESYQIRYWAAHDKEEA 842
+ +D PS+ P V ++S + W L +++ Y++ +W+ + E
Sbjct: 1140 EINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEW 1199
Query: 843 ANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIIS 902
+T+ L + T Y ++V A AG G S ++ TK+ P P I +
Sbjct: 1200 GEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKA 1259
Query: 903 SVRSGSRYIITW 914
S S +++W
Sbjct: 1260 VPSSASSVVVSW 1271
Score = 107 bits (267), Expect = 6e-23
Identities = 144/624 (23%), Positives = 228/624 (36%), Gaps = 60/624 (9%)
Query: 3 MWLLVSHLVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFP 62
MWL+ L++ S+ ED G F + + S+ V + C A SP
Sbjct: 61 MWLVTFLLLLDSLHKA---RPEDVGTSLYFVNDSLQQVTFSSSVG--VVVPCPAAGSPSA 115
Query: 63 VYKWRMNNGD--VDLTSDRYSMVGGNLVI--------NNPDKQKDAGIYYCLASNNYGMV 112
+W + GD D+ R+ G L + N+ D Y+C A N G +
Sbjct: 116 ALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDND---YFCTAENAAGKI 172
Query: 113 RSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSY-RWLLNEFPVFIT 171
RS + + +P+ + R G V C P + +S W E
Sbjct: 173 RSPNIRVKAVFREPYTVRVEDQ-RSMRGNVAVFKCLIPSSVQEYVSVVSW---EKDTVSI 228
Query: 172 MDKRRFVSQTNGNLYIANVEASDK-GNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYP 230
+ + RF +G LYI++V+ D Y C ++ S L + P
Sbjct: 229 IPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIP-- 286
Query: 231 ADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQ 290
I+ F G V L C A G P+P IRW K P+P+ + + L I +++
Sbjct: 287 -TILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITGLTISDLR 345
Query: 291 LEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPT 350
ED G Y CE N G + + V + IGS + C TG P T
Sbjct: 346 TEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFT 405
Query: 351 IRWLKNGYAYHKGE-----------LRLYDVTFENAGMYQCIAENTYGAIYANAELKILA 399
IRW +N E L + ++G YQC A A + +
Sbjct: 406 IRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALED 465
Query: 400 LAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLV-----NSSRILIWE 454
P + +K + G + + C K AP P +W+ E +V +++ + +
Sbjct: 466 GTPRIVSSFSEK--VVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSD 523
Query: 455 DGSLEINNITR---NDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENA 511
++ N+T DGG+Y C A N G A + + P I A N G +
Sbjct: 524 GTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS-IRAMRNITAVAGRDT 582
Query: 512 TMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQL-KHAGRY 570
+ C P + W + ++ N + ++ NG L + + Q G Y
Sbjct: 583 LINCRVIGYPYYSIK--WYKDALLLPDNHRQVVFE-------NGTLKLTDVQKGMDEGEY 633
Query: 571 TCTAQTIVDNS-SASADLVVRGPP 593
C+ S S S + V+ PP
Sbjct: 634 LCSVLIQPQLSISQSVHVAVKVPP 657
Score = 62.0 bits (149), Expect = 3e-09
Identities = 57/241 (23%), Positives = 102/241 (42%), Gaps = 16/241 (6%)
Query: 460 INNITRNDGGIYTCFAENNRGKANSTGTLVITD----PTRIILAPINADITVGENATMQC 515
I ++ R + A + G+ NS+ + I P +II ++ + C
Sbjct: 1312 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPC 1371
Query: 516 AASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQ 575
+ DPA + + I + + + ++ +NG LL+R + + +G YTCTA
Sbjct: 1372 NSVGDPAPAVKWTKDSEDSAIPVSMDG-----HRLIHTNGTLLLRAVKAEDSGYYTCTAT 1426
Query: 576 TIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILS 635
+ +L+V+ PP P L + A+S+ LTW G + S I + +Q S
Sbjct: 1427 NTGGFDTIIVNLLVQVPPDQP-RLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNS 1485
Query: 636 DDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAP 695
++WKD I + + + L Y+ ++ A N++G G S KT G P
Sbjct: 1486 EEWKDV-----FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRIS-EIIEAKTHGREP 1539
Query: 696 N 696
+
Sbjct: 1540 S 1540
Score = 53.5 bits (127), Expect = 1e-06
Identities = 78/316 (24%), Positives = 128/316 (40%), Gaps = 39/316 (12%)
Query: 593 PGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNM 652
PGPP G++ A+SV ++W + + I KYTI + S + P E +
Sbjct: 1251 PGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGS-----GQPAPSEYETSP 1305
Query: 653 EAA--RAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNR 710
E R L +Y V A + GRG S ++ + A AP+ + GG
Sbjct: 1306 EQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSS---EKVTIEPAGK--APAKIISFGG--- 1357
Query: 711 ELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQ 770
T+T + N+ G P +W K + D+ V D T
Sbjct: 1358 --TVTTPWMKDVRLPCNSVG-----DPAPAVKWTK---DSEDSAIPVSMDGHRLIHTNGT 1407
Query: 771 VKVKAFNNKGDGPYSLVA---------VINSAQDAPSEAPTEVGVKVLSSSEISVHWEHV 821
+ ++A + G Y+ A ++N P + P + V S+S I++ W
Sbjct: 1408 LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQP-RLTVSKTSASSITLTWIPG 1466
Query: 822 LE--KIVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCG 879
+ + ++Y + D E V ++S E S +L++L T Y +++ A NS G G
Sbjct: 1467 DNGGSSIRGFVLQY--SVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSG 1524
Query: 880 PPSDMIEAFTKKAPPS 895
S++IEA T PS
Sbjct: 1525 RISEIIEAKTHGREPS 1540
Score = 44.3 bits (103), Expect = 6e-04
Identities = 49/222 (22%), Positives = 90/222 (40%), Gaps = 24/222 (10%)
Query: 743 WKKV-TVTNPD-TGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINS-------- 792
W+K TV +PD RY + +K+K + +GD + INS
Sbjct: 882 WEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPAD-RGDSVFFSCHAINSYGEDRGLI 940
Query: 793 ---AQDAPSEAPTEVGVKVLSSSEISVHWEHVLE--KIVESYQIRYWAAHDK---EEAAN 844
Q+ P P E+ ++ + + +++ W + I+ + I Y D +++
Sbjct: 941 QLTVQEPPD--PPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTR 998
Query: 845 RVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSV 904
+ T + A + +L P + Y I + + N G PS + T++A P PP ++
Sbjct: 999 NISPTINQ--ANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQ 1056
Query: 905 RSGSRYI-ITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYS 945
S+ I +TW + GY++ YR + YS
Sbjct: 1057 PVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYS 1098
Score = 42.0 bits (97), Expect = 0.003
Identities = 30/98 (30%), Positives = 45/98 (45%), Gaps = 7/98 (7%)
Query: 230 PADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEP------MPSTAEISTSGAV 283
PA I+ V ++V L C ++G+P P ++W K E M I T+G +
Sbjct: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTL 1408
Query: 284 LKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPE 321
L + ++ ED G Y C A N G D + VQ P+
Sbjct: 1409 L-LRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPD 1445
Score = 40.4 bits (93), Expect = 0.008
Identities = 42/175 (24%), Positives = 79/175 (45%), Gaps = 20/175 (11%)
Query: 712 LTITWAPLSREYHYGNNF-GYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQ 770
+T+TW P G++ G+++ + + EEWK V +++ + K +++ T ++
Sbjct: 1459 ITLTWIPGDNG---GSSIRGFVLQYSVDNSEEWKDVFISSSERS---FKLDSLKCGTWYK 1512
Query: 771 VKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVH---WEH---VLEK 824
VK+ A N+ G G S + + PS + + ++S+ ++ W + +
Sbjct: 1513 VKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITA 1572
Query: 825 IVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCG 879
IV Y+ + A A + +V L L T Y + + ACNSAGCG
Sbjct: 1573 IVLEYRPKGTWAWQGLRANSSGEVF-------LTELREATWYELRMRACNSAGCG 1620
Score = 35.8 bits (81), Expect = 0.21
Identities = 20/65 (30%), Positives = 28/65 (43%), Gaps = 13/65 (20%)
Query: 336 DLYWPCVATGKPIPTIRWLKNG-------------YAYHKGELRLYDVTFENAGMYQCIA 382
D+ PC + G P P ++W K+ + G L L V E++G Y C A
Sbjct: 1366 DVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTA 1425
Query: 383 ENTYG 387
NT G
Sbjct: 1426 TNTGG 1430
Score = 35.8 bits (81), Expect = 0.21
Identities = 36/154 (23%), Positives = 57/154 (37%), Gaps = 37/154 (24%)
Query: 421 VIIECKPKAAPKPKFSWSKGTEW----LVNSSRILIWEDGSLEINNITRNDGGIYTCFAE 476
V + C P P W+K +E + LI +G+L + + D G YTC A
Sbjct: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTAT 1426
Query: 477 NNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVW------- 529
N G L++ P P +TV + + A +T W
Sbjct: 1427 NTGGFDTIIVNLLVQVP------PDQPRLTVSKTS----------ASSITLTWIPGDNGG 1470
Query: 530 -SFNGYVIDFNKENIH---------YQRNFMLDS 553
S G+V+ ++ +N +R+F LDS
Sbjct: 1471 SSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDS 1504
Score = 33.5 bits (75), Expect = 1.0
Identities = 24/86 (27%), Positives = 36/86 (41%), Gaps = 10/86 (11%)
Query: 50 VSLNCRARASPFPVYKWRMNNGD----VDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 105
V L C + P P KW ++ D V + R G L++ K +D+G Y C A
Sbjct: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAV-KAEDSGYYTCTA 1425
Query: 106 SNNYGMVRSTEATLSFGYLDPFPPEE 131
+N G T+ L PP++
Sbjct: 1426 TNTGGF-----DTIIVNLLVQVPPDQ 1446
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 191 bits (484), Expect = 4e-48
Identities = 211/817 (25%), Positives = 330/817 (40%), Gaps = 110/817 (13%)
Query: 170 ITMDKRRFVSQTNGNLYIANVEAS-----DKGNYSCFVSSPSITKSVFSKFIPLIP--IP 222
++ D+R+ + +G+L+I+NV S D+G Y C + S+ ++ S+ LI +P
Sbjct: 96 VSDDRRQLLP--DGSLFISNVVHSKHNKPDEGYYQCVATVESLG-TIISRTAKLIVAGLP 152
Query: 223 ERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMP-STAEISTSG 281
T++P P+ VYA G N L C + VP +RW + +P+ I
Sbjct: 153 RFTSQPEPSS-------VYA--GNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPS 203
Query: 282 AVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEV---------D 332
+L I N D G+Y C E+ G K+ + ++ P+ E I+D
Sbjct: 204 GMLVISNATEGDGGLYRCVVES-GGPPKYSDEVELKVLPD-PEVISDLVFLKQPSPLVRV 261
Query: 333 IGSDLYWPCVATGKPIPTIRWLKNGYAYHK-----------GELRLYDVTFENAGMYQCI 381
IG D+ PCVA+G P PTI+W+KN A G L + DVT ++AG Y CI
Sbjct: 262 IGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCI 321
Query: 382 AENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGT 441
A+N I A AEL + A P F P I A + ++ EC+ P P W K
Sbjct: 322 ADNGNETIEAQAELTVQA-QPEFLKQPTN--IYAHESMDIVFECEVTGKPTPTVKWVKNG 378
Query: 442 EWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPI 501
+ ++ S I ++ +L++ + ++D G Y C AEN+ G A + L+I + P+
Sbjct: 379 DMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPL 438
Query: 502 NADITVGENATMQCAASFDPALDLTFVWSFNG---------YVIDFNKENIHYQRNFMLD 552
+A AS + W Y + + KE I +R
Sbjct: 439 -------PSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTS 491
Query: 553 SNGELLIRNAQLKHAGRY--TCTAQTIVDNSSASADLVVRGP-----PGPPGGLRIEDIR 605
GE+ + L A Y AQ + +SA L V PGP LR
Sbjct: 492 HPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAAS 551
Query: 606 ATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWME 665
TS+ +TW + I Y + +D +D ++ + + L + E
Sbjct: 552 PTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQD-------VDVSSHSYTINGLKKYTE 604
Query: 666 YEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHY 725
Y FRVVA N G G S P ++T P+ AP ++ ++ + I W P +
Sbjct: 605 YSFRVVAYNKHGPG-VSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQN 663
Query: 726 GNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGP-- 783
G GY + ++ VT T + E + T + +V A G GP
Sbjct: 664 GQITGYKIRYR--KASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPAT 721
Query: 784 -YSLVAVINSAQDAP--SEAPTEVGVKVLSSSEISVHWEHVLEK--IVESYQIRYWAAHD 838
+ S D E P+ + V+ L +S I V W + +V Y I Y
Sbjct: 722 DWLSAETFESDLDETRVPEVPSSLHVRPLVTS-IVVSWTPPENQNIVVRGYAIGYGIG-- 778
Query: 839 KEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPP------------SDMIE 886
A ++V ++ +ENL P + Y I + A N+ G G P + ++
Sbjct: 779 -SPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVD 837
Query: 887 AFTKKAP--------PSQPP-RIISSVRSGSRYIITW 914
F AP P PP + +S+ S ITW
Sbjct: 838 LFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITW 874
Score = 176 bits (447), Expect = 8e-44
Identities = 187/799 (23%), Positives = 314/799 (39%), Gaps = 84/799 (10%)
Query: 230 PADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK---VLEPMPSTAEISTSGAVLKI 286
P +V+ D ++ G +V L C A P P I W+K L + L I
Sbjct: 52 PFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFI 111
Query: 287 FNI-----QLEDEGIYECEA--ENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYW 339
N+ DEG Y+C A E++ A++ V P + + V G++
Sbjct: 112 SNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAIL 171
Query: 340 PCVATGKPIPTIRWLKNG---------YAYHKGELRLYDVTFENAGMYQCIAENTYGAIY 390
C +P +RW +N G L + + T + G+Y+C+ E+ Y
Sbjct: 172 NCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKY 231
Query: 391 AN-AELKIL---ALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWL-- 444
++ ELK+L + ++ G V++ C P P W K E L
Sbjct: 232 SDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDT 291
Query: 445 VNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINAD 504
+S R+++ GSLEI+++T +D G Y C A+N + L + + P N
Sbjct: 292 ESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIY 351
Query: 505 ITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQL 564
+ +C + P T W NG + + F + L +
Sbjct: 352 AHESMDIVFECEVTGKPT--PTVKWVKNG-------DMVIPSDYFKIVKEHNLQVLGLVK 402
Query: 565 KHAGRYTCTAQTIVDNSSASADLVV-------RGP-PGPPGGLRIEDIRATSVALTW-SR 615
G Y C A+ V N+ A A L++ GP P P + + + LTW +
Sbjct: 403 SDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTP 462
Query: 616 GSDNHSPISKYTI-QTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATN 674
SD H Y++ TK ++ + + + P G M+ +L+P Y FRV+A N
Sbjct: 463 ASDPHGDNLTYSVFYTKEGIARERVENTSHP----GEMQVT-IQNLMPATVYIFRVMAQN 517
Query: 675 TLGRGEPSIP-----SNRIKTDGAAPNVAPSDVGGGGGRNRELTITW-APLSREYHYGNN 728
G GE S P ++ G APN+ +T+TW P+S N
Sbjct: 518 KHGSGESSAPLRVETQPEVQLPGPAPNLR-----AYAASPTSITVTWETPVSGNGEIQNY 572
Query: 729 FGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVA 788
Y + K D E+ + D + + + T + +V A+N G G +
Sbjct: 573 KLYYME-KGTDKEQ-------DVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDV 624
Query: 789 VINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKI----VESYQIRYWAAHDKEEAAN 844
+ + D PS AP + ++V +S I +HW+ + Y+IRY A K +
Sbjct: 625 AVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTE 684
Query: 845 RVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMI--EAFTKKAPPSQPPRIIS 902
+ V+ + S +E L T+Y V A G GP +D + E F ++ P + S
Sbjct: 685 TL-VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPS 743
Query: 903 SVRSG---SRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKL---YSTHKHSIEVPIP 956
S+ + +++W + V GY + Y H + Y ++IE P
Sbjct: 744 SLHVRPLVTSIVVSW--TPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDP 801
Query: 957 RDGEYVVEVRAHSDGGDGV 975
YV+ ++A ++ G+G+
Sbjct: 802 -SSHYVITLKAFNNVGEGI 819
Score = 164 bits (415), Expect = 4e-40
Identities = 232/1037 (22%), Positives = 403/1037 (38%), Gaps = 136/1037 (13%)
Query: 32 FEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSD--RYSMVGGNLVI 89
F +P++T+ S V LNC A + P P +W+ + ++L SD R + G+L I
Sbjct: 55 FLVEPVDTLSVRGS---SVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFI 111
Query: 90 NNPDKQK----DAGIYYCLAS-NNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMV 144
+N K D G Y C+A+ + G + S A L L F + P V G +
Sbjct: 112 SNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPS-SVYAGNNAI 170
Query: 145 LLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 204
L C+ + RW N P+ + R + +G L I+N D G Y C V S
Sbjct: 171 LNCEVNADLVPFV--RWEQNRQPLLLD---DRVIKLPSGMLVISNATEGDGGLYRCVVES 225
Query: 205 PSITKSVFSKFIPLIPIPERTTKPYPADIVV--QFKDVYALMGQNVTLECFALGNPVPDI 262
K + ++P PE + D+V Q + ++GQ+V L C A G P P I
Sbjct: 226 GGPPKYSDEVELKVLPDPEVIS-----DLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTI 280
Query: 263 RWRK---VLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAF 319
+W K L+ S + +G L+I ++ +D G Y C A+N + QA + VQA
Sbjct: 281 KWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQ 340
Query: 320 PEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNG---------YAYHKGELRLYDV 370
PE+++ + D+ + C TGKP PT++W+KNG + L++ +
Sbjct: 341 PEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGL 400
Query: 371 TFENAGMYQCIAENTYGAIYANAELKILALAP--TFEMNPMKKKILAAKGGRVIIEC--- 425
+ G YQCIAEN G A A+L IL AP T + + ++A+ I+
Sbjct: 401 VKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWR 460
Query: 426 KPKAAPK------PKFSWSKG--TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAEN 477
P + P F +G E + N+S + + I N+ I+ A+N
Sbjct: 461 TPASDPHGDNLTYSVFYTKEGIARERVENTSHP---GEMQVTIQNLMPATVYIFRVMAQN 517
Query: 478 NRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVID 537
G S+ L + + L G ++ A+ ++ +T+ +G
Sbjct: 518 KHGSGESSAPLRVETQPEVQLP--------GPAPNLRAYAASPTSITVTWETPVSGNGEI 569
Query: 538 FNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSS-----ASADLVVRG- 591
N + + ++ + + ++ + + +YT + +V + ++ D+ VR
Sbjct: 570 QNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTL 629
Query: 592 ---PPGPPGGLRIEDIRATSVALTWS--RGSDNHSPISKYTIQTKTILSDDWKDAKTDPP 646
P P L +E + S+ + W + + I+ Y I+ + + +
Sbjct: 630 SDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKAS----RKSDVTET 685
Query: 647 IIEGNMEAARAVDLIPWMEYEFRVVATNTLGRG-----------EPSIPSNRIKTDGAAP 695
++ G + L EY FRV A G G E + R+ ++
Sbjct: 686 LVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSL 745
Query: 696 NVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGR 755
+V P + ++W P + GY + + G D +
Sbjct: 746 HVRPLVT--------SIVVSWTPPENQNIVVR--GYAIGY----GIGSPHAQTIKVDYKQ 791
Query: 756 YVHKDETMSPSTAFQVKVKAFNNKGDG----------PYSLVA-----VINS-----AQD 795
+ E + PS+ + + +KAFNN G+G P++ + VIN+
Sbjct: 792 RYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDP 851
Query: 796 APSEAPTEVGVKVLSSSEISVHW-EHVLEKIVESYQIRYWAAHDKEEAANRVQ---VTSQ 851
P P V +LS I + W ++ L K + RY+ K + +
Sbjct: 852 TPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANAT 911
Query: 852 EYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPR---IISSVRSGS 908
S + L P+T Y V S T + P+ PP+ ++S
Sbjct: 912 TLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPK 971
Query: 909 RYIITWDHVVALSNESTVTGYKVLYRPDGQ---HDGKLY----STHKHSIEVPIPRDGEY 961
I+ W + + +TGY + Y D HD + + H I+ + D Y
Sbjct: 972 TIIVNWQPPSEANGK--ITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQ-ELTLDTPY 1028
Query: 962 VVEVRAHSDGGDGVVSQ 978
+++A + G G +S+
Sbjct: 1029 YFKIQARNSKGMGPMSE 1045
Score = 96.7 bits (239), Expect = 1e-19
Identities = 202/930 (21%), Positives = 341/930 (36%), Gaps = 129/930 (13%)
Query: 52 LNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGM 111
LNC A P +W N + L + G LVI+N + D G+Y C+ +
Sbjct: 171 LNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNAT-EGDGGLYRCVVESGGPP 229
Query: 112 VRSTEATLSFGYLDP-------FPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLN 164
S E L DP F + P VRV G+ +VL C P + +W+ N
Sbjct: 230 KYSDEVELKV-LPDPEVISDLVFLKQPSPLVRVI-GQDVVLPCVAS-GLPTP-TIKWMKN 285
Query: 165 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPER 224
E T R V G+L I++V D G Y C + + T + E
Sbjct: 286 E-EALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQA---------EL 335
Query: 225 TTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPM-PSTAEISTSGAV 283
T + P + + Q ++YA ++ EC G P P ++W K + + PS
Sbjct: 336 TVQAQP-EFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN 394
Query: 284 LKIFNIQLEDEGIYECEAENIRGKDKHQARIYV-QAFPEWVEHINDTEVDIGSDLY---- 338
L++ + DEG Y+C AEN G + A++ + + P + D+ + L
Sbjct: 395 LQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRF 454
Query: 339 ----WPCVAT---GKPIP-TIRWLKNGYAY-------HKGELRLYDVTFEN-----AGMY 378
W A+ G + ++ + K G A H GE++ VT +N ++
Sbjct: 455 IKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ---VTIQNLMPATVYIF 511
Query: 379 QCIAENTYGAIYANAELKILALAPTFEMNPMKK-KILAAKGGRVIIECKPKAAPKPK--- 434
+ +A+N +G+ ++A L++ P + AA + + + + +
Sbjct: 512 RVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQN 571
Query: 435 ---FSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVIT 491
+ KGT+ + + S IN + + + A N G ST + +
Sbjct: 572 YKLYYMEKGTD----KEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVR 627
Query: 492 DPTRI-ILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFM 550
+ + AP N + V + ++ + P T GY I + K +
Sbjct: 628 TLSDVPSAAPQNLSLEVRNSKSIMI--HWQPPAPATQNGQITGYKIRYRKASRKSDVTET 685
Query: 551 LDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASA-----------DLVVRGPPGPPGGL 599
L S +L L Y + N + A DL P P L
Sbjct: 686 LVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSL 745
Query: 600 RIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVD 659
+ + TS+ ++W+ + + + Y I I S + K D +E +
Sbjct: 746 HVRPL-VTSIVVSWTPPENQNIVVRGYAIGYG-IGSPHAQTIKVDYKQRYYTIE-----N 798
Query: 660 LIPWMEYEFRVVATNTLGRGEPSIPS--NRIKTDGA-----------------APNVAPS 700
L P Y + A N +G G P S R TD + P + P
Sbjct: 799 LDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPV 858
Query: 701 DVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTN-PDTGRYVHK 759
V + + ITWA S H + + WK TN P +Y +
Sbjct: 859 GVQASILSHDTIRITWADNSLPKHQK------ITDSRYYTVRWK----TNIPANTKYKNA 908
Query: 760 DET--------MSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGV--KVL 809
+ T + P+T ++ V + +S+ A + + P+ P +V V K
Sbjct: 909 NATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEG 968
Query: 810 SSSEISVHWEHVLEKI--VESYQIRYWAAHDKEEAANRV--QVTSQEYSARLENLLPDTQ 865
I V+W+ E + Y I Y++ E + V V + +++ L DT
Sbjct: 969 KPKTIIVNWQPPSEANGKITGYII-YYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTP 1027
Query: 866 YFIEVGACNSAGCGPPSDMIEAFTKKAPPS 895
Y+ ++ A NS G GP S+ ++ T KA S
Sbjct: 1028 YYFKIQARNSKGMGPMSEAVQFRTPKADSS 1057
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform
2 precursor [Homo sapiens]
Length = 1899
Score = 184 bits (466), Expect = 5e-46
Identities = 179/674 (26%), Positives = 280/674 (41%), Gaps = 75/674 (11%)
Query: 341 CVATGKPIPTIRWLKNGYAYHKGELRLYDV--------------TFENAGMYQCIAENTY 386
C ATG P P I W K G + + T + +Y+C+A N
Sbjct: 45 CQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNV 104
Query: 387 GAIYANAELKILAL------APTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKG 440
G I + L +L PT +M P K + + ++ C P P+ +W K
Sbjct: 105 GEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATML--CAASGNPDPEITWFKD 162
Query: 441 ---TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTG----TLVITDP 493
+ N+ RI G+L+I +D G Y C A N+ G S V P
Sbjct: 163 FLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVP 222
Query: 494 TRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDS 553
R + P N +I G + + C A P + +V G ++++ RN +L+
Sbjct: 223 PRFSIPPTNHEIMPGGSVNITCVAVGSP---MPYVKWMLGAEDLTPEDDMPIGRN-VLEL 278
Query: 554 NGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTW 613
N ++ + YTC A + + A A + V+ P PPG + + ATS+ LTW
Sbjct: 279 N--------DVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTW 330
Query: 614 SRGSDNHSPISKYTIQTKTILSDD-WKDAKTDPPIIEGNMEAARAV-DLIPWMEYEFRVV 671
G N P+S Y IQ K S++ +K+ I+G +V L P+ +YEFRVV
Sbjct: 331 DSG--NPEPVSYYIIQHKPKNSEELYKE-------IDGVATTRYSVAGLSPYSDYEFRVV 381
Query: 672 ATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGY 731
A N +GRG PS P +T AP+ AP DV + + + W E G GY
Sbjct: 382 AVNNIGRGPPSEPV-LTQTSEQAPSSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGY 438
Query: 732 IVAFKPFDGE---EWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVA 788
V + + W K V + + + P + VKV AF + GDGP S
Sbjct: 439 RVYYTMDPTQHVNNWMKHNVADSQ----ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDI 494
Query: 789 VINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANRVQV 848
+ + P + P + S + I + W + +Y++ Y EE ++
Sbjct: 495 QVITQTGVPGQ-PLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEP 553
Query: 849 TSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVR-SG 907
+ S RL+ L P++ Y+ + A + G G + I A T ++ PS PP+ IS S
Sbjct: 554 GT---SYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSS 610
Query: 908 SRYIITWDHVVALSNESTVTGYKVLYRP-DGQHD------GKLYSTHKHSIEVPIPRDGE 960
+ +++W +T Y + Y DG+ D G T K+ +E + + E
Sbjct: 611 TSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLE-QLEKWTE 669
Query: 961 YVVEVRAHSDGGDG 974
Y + V AH+D G G
Sbjct: 670 YRITVTAHTDVGPG 683
Score = 122 bits (307), Expect = 1e-27
Identities = 180/789 (22%), Positives = 304/789 (38%), Gaps = 82/789 (10%)
Query: 246 QNVTLECFALGNPVPDIRWRKVLEPMPSTAEIST-----SGAVLKIFNIQLEDEGIYECE 300
+ T+ C A GNP P+I W K P+ ++ SGA L+I + D+G YEC
Sbjct: 141 RTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGA-LQIEQSEESDQGKYECV 199
Query: 301 AENIRG-KDKHQARIYVQAF---PEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWL-- 354
A N G + A +YV+ P + + E+ G + CVA G P+P ++W+
Sbjct: 200 ATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLG 259
Query: 355 ------KNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNP 408
++ + L L DV + Y C+A +T G I A A++ + AL P
Sbjct: 260 AEDLTPEDDMPIGRNVLELNDV--RQSANYTCVAMSTLGVIEAIAQITVKALP-----KP 312
Query: 409 MKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDG----SLEINNIT 464
++ I P+P S+ NS + DG + ++
Sbjct: 313 PGTPVVTESTATSITLTWDSGNPEP-VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLS 371
Query: 465 RNDGGIYTCFAENNRGKAN-STGTLVITDPTRIILAP--INADITVGENATMQCAASFDP 521
+ A NN G+ S L T AP + A + +Q +P
Sbjct: 372 PYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEP 431
Query: 522 ALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGE---LLIRNAQLKHAGRYTCTAQTIV 578
+ GY + + + + N+M + + I N + A T +
Sbjct: 432 NGQI------QGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 485
Query: 579 DNSSASADLVV---RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILS 635
+ S+D+ V G PG P + E TS+ L+W+ P TI ++
Sbjct: 486 GDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT-------PPRSDTIANYELVY 538
Query: 636 DDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAP 695
D + + IE + R L P Y FR+ A + G G S +T + P
Sbjct: 539 KDGEHGEEQRITIEPGT-SYRLQGLKPNSLYYFRLAARSPQGLGA-STAEISARTMQSKP 596
Query: 696 NVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTN--PDT 753
+ P D+ + + ++W P E G Y + + DGE+ K + DT
Sbjct: 597 SAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDT 656
Query: 754 GRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSE 813
+Y+ E + T +++ V A + G GP SL +I + +D PS P +V V+ ++S+
Sbjct: 657 TKYLL--EQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS 714
Query: 814 ISVHWEHVLEK----IVESYQIRYWAAHDKEEAANRVQV------------TSQEYSARL 857
+ V W + + YQ+ Y + E + + E+ +
Sbjct: 715 VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMII 774
Query: 858 ENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHV 917
L P+T Y + V A + G G S T A P +P +I+ + + +I W
Sbjct: 775 SGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTA-LIQWHPP 833
Query: 918 VALSNESTVTGYKVLY-RPDGQHDGKLYSTHK--HSIEVPIPRDGEYVVEVRAHSDGGDG 974
V + GY++ + R D + L + K H I + YV + A + G G
Sbjct: 834 V--DTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 891
Query: 975 --VVSQVKI 981
+V ++ I
Sbjct: 892 EEMVKEISI 900
Score = 120 bits (301), Expect = 6e-27
Identities = 150/584 (25%), Positives = 239/584 (40%), Gaps = 110/584 (18%)
Query: 402 PTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSS-RILIWEDGSLEI 460
P F P+ + GG C+ P+PK W+K + + N ++ ++DGS +
Sbjct: 24 PRFTRTPVDQT--GVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSV 81
Query: 461 NNI----TRNDGGIYTCFAENNRGKAN-STGTLVITD-------PTRIILAPINADITVG 508
I T D IY C A NN G+ + ST V+ + PT I + P +
Sbjct: 82 LRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPT-IDMGPQLKVVERT 140
Query: 509 ENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAG 568
ATM CAAS +P ++T+ F N I R+ G L I ++ G
Sbjct: 141 RTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRS------GALQIEQSEESDQG 194
Query: 569 RYTCTAQTIVDNS-SASADLVVRG---PPG---PPGGLRIE---DIRATSVALTWSRGSD 618
+Y C A SA A+L VR PP PP I + T VA+
Sbjct: 195 KYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAV------G 248
Query: 619 NHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLG- 677
+ P K+ + + + +D D ++E N A + VA +TLG
Sbjct: 249 SPMPYVKWMLGAEDLTPED--DMPIGRNVLELNDVRQSA---------NYTCVAMSTLGV 297
Query: 678 ---------RGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSRE-YHYGN 727
+ P P + T+ A ++ T+TW + E Y
Sbjct: 298 IEAIAQITVKALPKPPGTPVVTESTATSI---------------TLTWDSGNPEPVSY-- 340
Query: 728 NFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLV 787
YI+ KP + EE K + T RY +SP + ++ +V A NN G GP S
Sbjct: 341 ---YIIQHKPKNSEELYK-EIDGVATTRY--SVAGLSPYSDYEFRVVAVNNIGRGPPSEP 394
Query: 788 AVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEK--IVESYQIRY----------WA 835
+ +++ APS AP +V ++LSS+ I V W+ E ++ Y++ Y W
Sbjct: 395 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWM 454
Query: 836 AHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPS 895
H+ ++ Q+T+ + NL+P Y ++V A S G GP S I+ T+ P
Sbjct: 455 KHNVADS----QITT------IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG 504
Query: 896 QPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQH 939
QP + S + +++W T+ Y+++Y+ DG+H
Sbjct: 505 QPLNFKAEPESETSILLSW----TPPRSDTIANYELVYK-DGEH 543
Score = 70.5 bits (171), Expect = 8e-12
Identities = 80/329 (24%), Positives = 146/329 (44%), Gaps = 35/329 (10%)
Query: 7 VSHLVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEGKV-SLNCRARASPFPVYK 65
V+ L+++ +T L E P F P++ + + G V S C+A P P
Sbjct: 4 VARLLLLLLTFFLRTDAETP---PRFTRTPVD----QTGVSGGVASFICQATGDPRPKIV 56
Query: 66 WRMNNGDVDLTSDRYSMV------GGNLVINNPDKQKDAGIYYCLASNNYGMVR-STEAT 118
W N +++ R+ ++ G L I +D IY C+ASNN G + ST T
Sbjct: 57 W--NKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLT 114
Query: 119 LSFGYLDP--FPPEER-PEVRVKEG-KGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDK 174
+ P FP + P+++V E + +LC + D W + PV + +
Sbjct: 115 VLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGN--PDPEITWFKDFLPVDTSNNN 172
Query: 175 RRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITK--SVFSKFIPLIPIPERTTKPYPAD 232
R +G L I E SD+G Y C ++ + T+ + + ++ + +P R + P P +
Sbjct: 173 GRIKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIP-PTN 231
Query: 233 IVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLE 292
+ + G +V + C A+G+P+P ++W E + ++ VL++ +++
Sbjct: 232 HEI-------MPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVR-- 282
Query: 293 DEGIYECEAENIRGKDKHQARIYVQAFPE 321
Y C A + G + A+I V+A P+
Sbjct: 283 QSANYTCVAMSTLGVIEAIAQITVKALPK 311
Score = 65.9 bits (159), Expect = 2e-10
Identities = 83/417 (19%), Positives = 157/417 (37%), Gaps = 34/417 (8%)
Query: 584 SADLVVRGPPGPPGGLRIEDIRATSVALTWSRG--SDNHSPISKYTIQTKTILSDDWKDA 641
SA + P PP + +TS+ ++W + I++Y+I+ + +D D
Sbjct: 588 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGED--DK 645
Query: 642 KTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSD 701
+ I + L W EY V A +G G S+ S I+T+ P+ P
Sbjct: 646 PHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESL-SVLIRTNEDVPSGPPRK 704
Query: 702 VGGGGGRNRELTITW-APLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNP--------- 751
V + + ++W +P+ + H G GY V + + E K +
Sbjct: 705 VEVEAVNSTSVKVSWRSPVPNKQH-GQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWE 763
Query: 752 --DTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVL 809
DT + + P T++ + V A+ KGDG S ++++ P + + +
Sbjct: 764 FDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQM 823
Query: 810 SSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIE 869
+++ I H ++ Y++++ E ++ + +E ++ Y
Sbjct: 824 NTALIQWHPPVDTFGPLQGYRLKF--GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR 881
Query: 870 VGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGY 929
+ A N G G + ++ P P + S + + ++W V +T Y
Sbjct: 882 LSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKY 941
Query: 930 KVLYRPDGQHDGKLYSTHKHSIEVP---------IPRDGEYVVEVRAHSDGGDGVVS 977
+LYR D + + VP + D Y V+VRAH+ G G S
Sbjct: 942 TLLYR-----DINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYS 993
Score = 48.1 bits (113), Expect = 4e-05
Identities = 85/399 (21%), Positives = 139/399 (34%), Gaps = 41/399 (10%)
Query: 556 ELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLR--IEDIRATSVALTW 613
+++I Q + + T TA T + + S +V PG R I + + + W
Sbjct: 771 DMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQW 830
Query: 614 SRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAA-RAVDLIPWMEYEFRVVA 672
D P+ Y ++ KD + + E A D+ Y FR+ A
Sbjct: 831 HPPVDTFGPLQGYRLKFGR------KDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSA 884
Query: 673 TNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYI 732
N +G GE + I + P P ++ G + + ++W P G Y
Sbjct: 885 RNKVGFGEEMVKEISIPEE--VPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYT 942
Query: 733 VAFKPFDGEEWKKVTVTNPDTGRYVHKDETMS-----PSTAFQVKVKAFNNKGDGPYSLV 787
+ ++ + P V D TM+ P T + VKV+A +KG GPYS
Sbjct: 943 LLYRDIN-------IPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYS-P 994
Query: 788 AVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANRVQ 847
+V VK + + + + WE I E+Y ++ +
Sbjct: 995 SVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWE-----IPENYNSAMPFKILYDDGKMVEE 1049
Query: 848 VTSQEYSARLENLLPDTQY-FIEVGACNSAGCGPPSDMIEAFTKKAPPS---QPPRIISS 903
V + + NL P+ Y F+ NSAG + T K P P I
Sbjct: 1050 VDGRATQKLIVNLKPEKSYSFVLTNRGNSAG-----GLQHRVTAKTAPDVLRTKPAFIGK 1104
Query: 904 VRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGK 942
+ V A N + GY ++ P + GK
Sbjct: 1105 TNLDGMITVQLPEVPANEN---IKGYYIIIVPLKKSRGK 1140
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,152,439
Number of Sequences: 37866
Number of extensions: 2076524
Number of successful extensions: 16515
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 267
Number of HSP's successfully gapped in prelim test: 237
Number of HSP's that attempted gapping in prelim test: 5966
Number of HSP's gapped (non-prelim): 4233
length of query: 1007
length of database: 18,247,518
effective HSP length: 112
effective length of query: 895
effective length of database: 14,006,526
effective search space: 12535840770
effective search space used: 12535840770
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.