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Search of human proteins with 27735025
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27735025 coiled-coil domain containing 149 isoform 1 [Homo
sapiens]
(267 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|195539368 coiled-coil domain containing 149 isoform 2 [Homo s... 520 e-148
gi|27735025 coiled-coil domain containing 149 isoform 1 [Homo sa... 520 e-148
gi|4504063 golgin 97 [Homo sapiens] 56 4e-08
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 55 6e-08
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap... 55 8e-08
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 55 8e-08
gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo sapi... 55 8e-08
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 53 3e-07
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 52 4e-07
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 52 4e-07
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 52 4e-07
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 52 4e-07
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi... 52 5e-07
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 50 2e-06
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 50 2e-06
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 50 2e-06
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 50 2e-06
gi|55770834 centromere protein F [Homo sapiens] 50 2e-06
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 50 3e-06
gi|21735548 centrosomal protein 2 [Homo sapiens] 50 3e-06
gi|10864047 epidermal growth factor receptor pathway substrate 1... 50 3e-06
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 49 4e-06
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 49 4e-06
gi|157042792 coiled-coil domain containing 64B [Homo sapiens] 49 4e-06
gi|109255236 centrosomal protein 63 isoform d [Homo sapiens] 49 5e-06
gi|109255226 centrosomal protein 63 isoform c [Homo sapiens] 49 5e-06
gi|62243374 MAD1-like 1 protein [Homo sapiens] 49 5e-06
gi|62243369 MAD1-like 1 protein [Homo sapiens] 49 5e-06
gi|62243332 MAD1-like 1 protein [Homo sapiens] 49 5e-06
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 49 6e-06
>gi|195539368 coiled-coil domain containing 149 isoform 2 [Homo
sapiens]
Length = 529
Score = 520 bits (1339), Expect = e-148
Identities = 267/267 (100%), Positives = 267/267 (100%)
Query: 1 MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR 60
MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR
Sbjct: 56 MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR 115
Query: 61 LGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASV 120
LGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASV
Sbjct: 116 LGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASV 175
Query: 121 DELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN 180
DELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN
Sbjct: 176 DELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN 235
Query: 181 LLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISD 240
LLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISD
Sbjct: 236 LLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISD 295
Query: 241 LKSLATALLETIHEKNMVIQHQRQTNK 267
LKSLATALLETIHEKNMVIQHQRQTNK
Sbjct: 296 LKSLATALLETIHEKNMVIQHQRQTNK 322
>gi|27735025 coiled-coil domain containing 149 isoform 1 [Homo
sapiens]
Length = 267
Score = 520 bits (1339), Expect = e-148
Identities = 267/267 (100%), Positives = 267/267 (100%)
Query: 1 MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR 60
MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR
Sbjct: 1 MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR 60
Query: 61 LGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASV 120
LGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASV
Sbjct: 61 LGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASV 120
Query: 121 DELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN 180
DELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN
Sbjct: 121 DELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN 180
Query: 181 LLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISD 240
LLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISD
Sbjct: 181 LLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISD 240
Query: 241 LKSLATALLETIHEKNMVIQHQRQTNK 267
LKSLATALLETIHEKNMVIQHQRQTNK
Sbjct: 241 LKSLATALLETIHEKNMVIQHQRQTNK 267
>gi|4504063 golgin 97 [Homo sapiens]
Length = 767
Score = 55.8 bits (133), Expect = 4e-08
Identities = 63/259 (24%), Positives = 112/259 (43%), Gaps = 29/259 (11%)
Query: 8 RHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGD 67
+H LKK+ L + L R+ + + L +S + L ++++ELQ+
Sbjct: 185 KHMLLKKE-ESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYS----- 238
Query: 68 NKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVK 127
T+ +QR D I + A + L Q+ + + I+ L DLQ E Q+ +
Sbjct: 239 ------TLEEQR--DHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKE 290
Query: 128 EERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIA 187
+ + Q+KV L + L LSG E+ V L E ++ L+ +++ +S+ A
Sbjct: 291 DVITHLQEKVASLEKRLEQNLSGEEH----VQELLKEKTLAEQNLEDTRQQLLAARSSQA 346
Query: 188 KYKNALERRKNSKGQGKSSS----SALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKS 243
K N LE R Q +S G+++A++ Q + E L A Q S ++
Sbjct: 347 KAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQ--IQE-----LAAANQESSHVQQ 399
Query: 244 LATALLETIHEKNMVIQHQ 262
A AL + E+ ++ Q
Sbjct: 400 QALALEQQFLERTQALEAQ 418
Score = 45.4 bits (106), Expect = 5e-05
Identities = 41/153 (26%), Positives = 66/153 (43%), Gaps = 10/153 (6%)
Query: 48 KHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKE 107
K + EE Q+ G + + + ++A D + REDL QL R E
Sbjct: 7 KKIAEETAVAQRPGGATRIPRSVSKESVASMG-ADSGDDFASDGSSSREDLSSQLLRRNE 65
Query: 108 QIESLE---HDLQASVDELQDVKEE----RSSYQDKVERLNQELNHILSGHENRIID--V 158
QI LE D V LQ +KE+ +QD R QE N + ++ +
Sbjct: 66 QIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLA 125
Query: 159 DALCMENRYLQERLKQLHEEVNLLKSNIAKYKN 191
AL +++ E++ QL +E N+L + + + KN
Sbjct: 126 LALARKDQEWSEKMDQLEKEKNILTAQLQEMKN 158
Score = 28.1 bits (61), Expect = 8.4
Identities = 48/243 (19%), Positives = 101/243 (41%), Gaps = 39/243 (16%)
Query: 7 ERHQ-SLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQ 65
E+HQ S +K++E + QAN A++ ++ L + +E +++ +++
Sbjct: 96 EKHQDSSMRKFQE---------QNETFQANRAKM---AEGLALALARKDQEWSEKMDQLE 143
Query: 66 GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQ-LERAK-------EQIESLEHDLQ 117
+ +L + + + + R E E QQ L + K E + +E +L+
Sbjct: 144 KEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELE 203
Query: 118 ASVDELQDVKEE-------RSSYQDKVER-------LNQELNHILSGHENRIIDVDALCM 163
A EL +EE S K+E L ++ +H+++ + AL
Sbjct: 204 ARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQ 263
Query: 164 ENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQ-VQDL 222
+ + LQ ++QL ++ + + + ++ + + S L LS ++ VQ+L
Sbjct: 264 KEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVA---SLEKRLEQNLSGEEHVQEL 320
Query: 223 LSE 225
L E
Sbjct: 321 LKE 323
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 55.1 bits (131), Expect = 6e-08
Identities = 57/270 (21%), Positives = 125/270 (46%), Gaps = 16/270 (5%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEV 64
L+++ Q +K+++ + + +R + QL+ + + K L E+KEL+Q L +V
Sbjct: 834 LKKQMQKIKEQF---LQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQV 890
Query: 65 QGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQ 124
G+ + ++ RL E VR A + E +Q ++ ++++E+ LQ +++
Sbjct: 891 HGEKRTAEAELS--RLHREVAQVRQHMA-DLEGHLQSAQKERDEMETHLQSLQFDKEQMV 947
Query: 125 DVKEERSSYQDKVERLNQELNHILSGHENRIIDVDA-LCMENRYLQERLKQLHEEVNLLK 183
V E + + ++E L QE ++ + ++ + + L + ++ + K V +L
Sbjct: 948 AVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILS 1007
Query: 184 SNIAKYKNALERRKNSKG----QGKSSSSALTGVLSAKQVQDLLSEDHGCSLPAT--PQS 237
+ + A E G QG SS S+L +++Q L +E S T +
Sbjct: 1008 RRLQEALAAKEAADAELGQLRAQGGSSDSSLA---LHERIQALEAELQAVSHSKTLLEKE 1064
Query: 238 ISDLKSLATALLETIHEKNMVIQHQRQTNK 267
+ ++ +L + LE EK + ++ + Q ++
Sbjct: 1065 LQEVIALTSQELEESREKVLELEDELQESR 1094
Score = 39.7 bits (91), Expect = 0.003
Identities = 46/217 (21%), Positives = 89/217 (41%), Gaps = 12/217 (5%)
Query: 48 KHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKE 107
+HL E L Q+L E Q + + IA Q G EA + ++E Q++ AK
Sbjct: 611 EHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADML------DQEAAFMQIQEAKT 664
Query: 108 QIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRY 167
+E DLQ ++E + +E D L Q+L + R ++AL E+
Sbjct: 665 MVEE---DLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLD 721
Query: 168 LQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDH 227
L ++L E + + ++ + + + G+ + +++ + Q + ++ E
Sbjct: 722 LMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILE-- 779
Query: 228 GCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQ 264
+L A +L A L E E + ++ R+
Sbjct: 780 -AALQAAKSGKEELDRGARRLEEGTEETSETLEKLRE 815
Score = 39.3 bits (90), Expect = 0.004
Identities = 52/261 (19%), Positives = 114/261 (43%), Gaps = 33/261 (12%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPEKRKQANL-AQLLRDSQDRNKHLGEEIKE---LQQR 60
L ER Q+L+ + + + L E ++ L +Q L +S+++ L +E++E +++
Sbjct: 1040 LHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKK 1099
Query: 61 LGEVQGDNKLLRMTIAKQR-----LGDEAIGVRHF-------AAHEREDLVQQ------- 101
+ ++ NK L + + ++ LG +R A DLVQ
Sbjct: 1100 IKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAV 1159
Query: 102 LERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDAL 161
L+R +E+ ++H +QA L+ KE+ +S +++V E H + +++ +
Sbjct: 1160 LQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEV 1219
Query: 162 CMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQD 221
E + + +++L E + L+ K+ + + + + ++ L KQ+ +
Sbjct: 1220 KKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLL-----QKQLDE 1274
Query: 222 LLSEDHGCSLPATPQSISDLK 242
LS+ P Q + +LK
Sbjct: 1275 QLSKQ-----PVGNQEMENLK 1290
Score = 38.5 bits (88), Expect = 0.006
Identities = 61/274 (22%), Positives = 107/274 (39%), Gaps = 40/274 (14%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKH-LGEEIKELQQRLGE 63
L +R Q L+ +E +D KQ L Q S++++ L ELQ RLGE
Sbjct: 705 LLQRDQQLEALQQEHLD--------LMKQLTLTQEALQSREQSLDALQTHYDELQARLGE 756
Query: 64 VQGDNK--------------LLRMTIAKQRLGDEAI--GVRHFAAHEREDLVQQLERAKE 107
+QG+ +L + + G E + G R E+ + LE+ +E
Sbjct: 757 LQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLE-EGTEETSETLEKLRE 815
Query: 108 -------QIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDA 160
Q+E L+ + A ++Q +KE+ + VE ++ + + I ++ A
Sbjct: 816 ELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRD----ATSKDQLISELKA 871
Query: 161 LCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQ 220
+ L LK+L +E+ + + L R Q + + L G L + Q +
Sbjct: 872 ---TRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKE 928
Query: 221 DLLSEDHGCSLPATPQSISDLKSLATALLETIHE 254
E H SL + + + AL + I E
Sbjct: 929 RDEMETHLQSLQFDKEQMVAVTEANEALKKQIEE 962
Score = 35.4 bits (80), Expect = 0.052
Identities = 47/218 (21%), Positives = 93/218 (42%), Gaps = 19/218 (8%)
Query: 7 ERHQSLKKKYRELI-DGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQ 65
E +++LKK+ EL + ++ +K+K L L +Q K + + K + +G
Sbjct: 951 EANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQ---KEMKTKHKAYENAVG--- 1004
Query: 66 GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQD 125
I +RL EA+ + A E L Q + + +L +QA ELQ
Sbjct: 1005 ---------ILSRRL-QEALAAKEAADAELGQLRAQGGSSDSSL-ALHERIQALEAELQA 1053
Query: 126 VKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSN 185
V ++ + +++ + + L ++++++ E+R ++++K+L E L
Sbjct: 1054 VSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALE 1113
Query: 186 IAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLL 223
+ K L S + +S L L AK+ DL+
Sbjct: 1114 LEHEKGKLTGLGQSNAALREHNSILETAL-AKREADLV 1150
Score = 31.6 bits (70), Expect = 0.76
Identities = 27/113 (23%), Positives = 48/113 (42%), Gaps = 7/113 (6%)
Query: 89 HFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVE-------RLN 141
H + L QL++ + + +L L+AS E+ ++ R YQ ++ RL
Sbjct: 534 HDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQ 593
Query: 142 QELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALE 194
E+ HI G + ++ L +EN L ++L + K IA +E
Sbjct: 594 GEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIE 646
>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
sapiens]
Length = 693
Score = 54.7 bits (130), Expect = 8e-08
Identities = 56/230 (24%), Positives = 106/230 (46%), Gaps = 23/230 (10%)
Query: 3 NQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLG 62
++++E +SL + ++ + PSL P + ++ QD KHL +E++ L+ +L
Sbjct: 266 HRIQELERSLSELKNQMAE-PPSLAPPA-----VTSVVEQLQDEAKHLRQEVEGLEGKLQ 319
Query: 63 EVQGDNKLLRMTIA--KQRLGDEAIGVRHFAAH---EREDLVQQLERAKEQIESLEHDLQ 117
+N+ L + KQRL ++ +R A E+E L +Q ER +EQ ++L+ +
Sbjct: 320 SQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGE 379
Query: 118 ASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHE 177
+ Q ++++ + + ERL ++ E R+ D + E + +E Q E
Sbjct: 380 RLRKQEQRLRKQEERLRKEEERLQKQ--------EKRLWDQE----ERLWKKEERLQKQE 427
Query: 178 EVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDH 227
E L N K E + + + SAL K++Q+ L E+H
Sbjct: 428 ERLALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEH 477
Score = 43.1 bits (100), Expect = 3e-04
Identities = 41/193 (21%), Positives = 87/193 (45%), Gaps = 27/193 (13%)
Query: 13 KKKYRELIDGDPSLPPEKR-KQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLL 71
+ +Y + I G+ + E+ K + A+ L++ + R+ H I+EL++ L E+
Sbjct: 229 RDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIH---RIQELERSLSEL------- 278
Query: 72 RMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDV----K 127
K ++ + E L + + ++++E LE LQ+ V+ Q + K
Sbjct: 279 -----KNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSK 333
Query: 128 EERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIA 187
E++ Q++ E L ++ R+ + + LC +N L+E+ K L E+ L+
Sbjct: 334 EQKQRLQEQEEMLREQ-------EAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQ 386
Query: 188 KYKNALERRKNSK 200
+ + ER + +
Sbjct: 387 RLRKQEERLRKEE 399
>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
isoform 1 [Homo sapiens]
Length = 693
Score = 54.7 bits (130), Expect = 8e-08
Identities = 56/230 (24%), Positives = 106/230 (46%), Gaps = 23/230 (10%)
Query: 3 NQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLG 62
++++E +SL + ++ + PSL P + ++ QD KHL +E++ L+ +L
Sbjct: 266 HRIQELERSLSELKNQMAE-PPSLAPPA-----VTSVVEQLQDEAKHLRQEVEGLEGKLQ 319
Query: 63 EVQGDNKLLRMTIA--KQRLGDEAIGVRHFAAH---EREDLVQQLERAKEQIESLEHDLQ 117
+N+ L + KQRL ++ +R A E+E L +Q ER +EQ ++L+ +
Sbjct: 320 SQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGE 379
Query: 118 ASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHE 177
+ Q ++++ + + ERL ++ E R+ D + E + +E Q E
Sbjct: 380 RLRKQEQRLRKQEERLRKEEERLQKQ--------EKRLWDQE----ERLWKKEERLQKQE 427
Query: 178 EVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDH 227
E L N K E + + + SAL K++Q+ L E+H
Sbjct: 428 ERLALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEH 477
Score = 43.1 bits (100), Expect = 3e-04
Identities = 41/193 (21%), Positives = 87/193 (45%), Gaps = 27/193 (13%)
Query: 13 KKKYRELIDGDPSLPPEKR-KQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLL 71
+ +Y + I G+ + E+ K + A+ L++ + R+ H I+EL++ L E+
Sbjct: 229 RDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIH---RIQELERSLSEL------- 278
Query: 72 RMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDV----K 127
K ++ + E L + + ++++E LE LQ+ V+ Q + K
Sbjct: 279 -----KNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSK 333
Query: 128 EERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIA 187
E++ Q++ E L ++ R+ + + LC +N L+E+ K L E+ L+
Sbjct: 334 EQKQRLQEQEEMLREQ-------EAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQ 386
Query: 188 KYKNALERRKNSK 200
+ + ER + +
Sbjct: 387 RLRKQEERLRKEE 399
>gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo
sapiens]
Length = 693
Score = 54.7 bits (130), Expect = 8e-08
Identities = 56/230 (24%), Positives = 106/230 (46%), Gaps = 23/230 (10%)
Query: 3 NQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLG 62
++++E +SL + ++ + PSL P + ++ QD KHL +E++ L+ +L
Sbjct: 266 HRIQELERSLSELKNQMAE-PPSLAPPA-----VTSVVEQLQDEAKHLRQEVEGLEGKLQ 319
Query: 63 EVQGDNKLLRMTIA--KQRLGDEAIGVRHFAAH---EREDLVQQLERAKEQIESLEHDLQ 117
+N+ L + KQRL ++ +R A E+E L +Q ER +EQ ++L+ +
Sbjct: 320 SQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGE 379
Query: 118 ASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHE 177
+ Q ++++ + + ERL ++ E R+ D + E + +E Q E
Sbjct: 380 RLRKQEQRLRKQEERLRKEEERLQKQ--------EKRLWDQE----ERLWKKEERLQKQE 427
Query: 178 EVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDH 227
E L N K E + + + SAL K++Q+ L E+H
Sbjct: 428 ERLALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEH 477
Score = 43.1 bits (100), Expect = 3e-04
Identities = 41/193 (21%), Positives = 87/193 (45%), Gaps = 27/193 (13%)
Query: 13 KKKYRELIDGDPSLPPEKR-KQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLL 71
+ +Y + I G+ + E+ K + A+ L++ + R+ H I+EL++ L E+
Sbjct: 229 RDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIH---RIQELERSLSEL------- 278
Query: 72 RMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDV----K 127
K ++ + E L + + ++++E LE LQ+ V+ Q + K
Sbjct: 279 -----KNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSK 333
Query: 128 EERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIA 187
E++ Q++ E L ++ R+ + + LC +N L+E+ K L E+ L+
Sbjct: 334 EQKQRLQEQEEMLREQ-------EAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQ 386
Query: 188 KYKNALERRKNSK 200
+ + ER + +
Sbjct: 387 RLRKQEERLRKEE 399
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 52.8 bits (125), Expect = 3e-07
Identities = 51/214 (23%), Positives = 96/214 (44%), Gaps = 24/214 (11%)
Query: 29 EKRKQANLAQLLRDS-----QDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDE 83
E QA L +LL + Q R+K+ + I QR E++ K L + + + G E
Sbjct: 1399 EAEAQAELQRLLSKANAEVAQWRSKYEADAI----QRTEELEEAKKKLALRLQEAEEGVE 1454
Query: 84 AIGVRHFAAH--------EREDLVQQLERAKEQIESLE---HDLQASVDELQDVKEERSS 132
A + + E ED+ +LERA +L+ L+ +++E + +EE
Sbjct: 1455 AANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQR 1514
Query: 133 YQDKVER----LNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAK 188
+ +R L EL + GHE + ++ L EN+ LQE + L ++V+L +I +
Sbjct: 1515 ELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQE 1574
Query: 189 YKNALERRKNSKGQGKSSSSALTGVLSAKQVQDL 222
+ + + K + +++ G L ++ + L
Sbjct: 1575 LEKTKKALEGEKSEIQAALEEAEGALELEETKTL 1608
Score = 41.6 bits (96), Expect = 7e-04
Identities = 57/235 (24%), Positives = 108/235 (45%), Gaps = 20/235 (8%)
Query: 4 QLRERHQSLKKKYR-ELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRL- 61
++R++ + K + R E+ D ++ R +A+ +L R +D+ +++ELQ++L
Sbjct: 1261 RVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLA 1320
Query: 62 ------GEVQGDN-KLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEH 114
G +Q ++ +L R+ K+ L + + AA E+L +QLE + +L H
Sbjct: 1321 DASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAH 1380
Query: 115 DLQA---SVDELQDVKEERSSYQDKVERL----NQELNHILSGHE-NRIIDVDALCMENR 166
+QA D L++ EE + Q +++RL N E+ S +E + I + L +
Sbjct: 1381 AVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKK 1440
Query: 167 YLQERLKQLHEEV---NLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQ 218
L RL++ E V N S++ K K L+ +++ L KQ
Sbjct: 1441 KLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQ 1495
Score = 38.5 bits (88), Expect = 0.006
Identities = 37/158 (23%), Positives = 72/158 (45%), Gaps = 28/158 (17%)
Query: 29 EKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVR 88
EK KQA ++++ K+L EE+ L + + + + K L+ +Q LGD
Sbjct: 1014 EKEKQA--------TENKVKNLTEEMAALDESVARLTKEKKALQEA-HQQALGD------ 1058
Query: 89 HFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHIL 148
ED V L +AK ++E DL+ S+++ + ++ + ER ++L L
Sbjct: 1059 ---LQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMD-------TERAKRKLEGDL 1108
Query: 149 SGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNI 186
+ + D + + L+E+LK+ E++ L +
Sbjct: 1109 KLTQESVADA---AQDKQQLEEKLKKKDSELSQLSLRV 1143
Score = 37.0 bits (84), Expect = 0.018
Identities = 52/249 (20%), Positives = 108/249 (43%), Gaps = 49/249 (19%)
Query: 30 KRKQANLAQL---LRDSQDRNKHLGEEIKELQQRLGEVQGD---NKLLRMTIAKQRLGDE 83
K+K + L+QL + D Q + ++IKELQ R E++ + + R + KQR
Sbjct: 1130 KKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAE-- 1187
Query: 84 AIGVRHFAAHEREDLVQQLE---------------------RAKEQIESLEHDLQASVDE 122
AA E E+L ++LE R + ++E +A+V
Sbjct: 1188 -------AARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAA 1240
Query: 123 LQ--------DVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQ 174
L+ ++ E+ S Q ++L +E + + ++ +V+ L ++ +
Sbjct: 1241 LRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRT 1300
Query: 175 LHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSE-DHGCSLPA 233
++++ K + + + L +G+ ++ S L+ +L K+ L+S+ G +L A
Sbjct: 1301 YEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKEC--LISQLSRGKALAA 1358
Query: 234 TPQSISDLK 242
QS+ +L+
Sbjct: 1359 --QSLEELR 1365
Score = 36.2 bits (82), Expect = 0.031
Identities = 50/196 (25%), Positives = 84/196 (42%), Gaps = 32/196 (16%)
Query: 6 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQ 65
R+R L + REL + R +A +A L R + LGE++ LQ+ +++
Sbjct: 1214 RKREAELGRLRRELEEA------ALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLE 1267
Query: 66 GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESL-------EHDLQA 118
+ LRM V AA+ V+ L RAK E L + +
Sbjct: 1268 KEKSELRME------------VDDLAAN-----VETLTRAKASAEKLCRTYEDQLSEAKI 1310
Query: 119 SVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVD-ALCMENRYLQERLKQLHE 177
V+ELQ + S+ + +++ + EL+ +L E I + + + L+E +QL E
Sbjct: 1311 KVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEE 1370
Query: 178 EVNLLKSNIAKYKNAL 193
E + KS +A AL
Sbjct: 1371 E-SKAKSALAHAVQAL 1385
Score = 31.2 bits (69), Expect = 0.99
Identities = 41/166 (24%), Positives = 66/166 (39%), Gaps = 36/166 (21%)
Query: 34 ANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAH 93
A +A+ L+ QD + HL K L+Q + E+Q R+ A+Q
Sbjct: 1812 AMMAEELKKEQDTSAHLERMKKTLEQTVRELQA-----RLEEAEQ--------------- 1851
Query: 94 EREDLVQQLERAKEQIESLE---HDLQASVDELQDVKEERSSYQDKVERLNQELNHILSG 150
L K+Q++ LE +L+A +D Q E K ER +EL +
Sbjct: 1852 ------AALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEE 1905
Query: 151 HENRIIDVDALCMENRYLQERLK----QLHEEVNLLKSNIAKYKNA 192
+ + L + LQ ++K Q E +N+AKY+ A
Sbjct: 1906 DRKNLARMQDLVDK---LQSKVKSYKRQFEEAEQQANTNLAKYRKA 1948
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 52.4 bits (124), Expect = 4e-07
Identities = 36/154 (23%), Positives = 75/154 (48%), Gaps = 11/154 (7%)
Query: 30 KRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRH 89
+R Q + ++D + NK L E IKE +L +++ + + ++ + + E
Sbjct: 572 QRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE------ 625
Query: 90 FAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILS 149
A E E+ + LE+ E ++ +L+ + ++++ +++E S ++ER N++L L
Sbjct: 626 -RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENS----ELERENRKLKKTLD 680
Query: 150 GHENRIIDVDALCMENRYLQERLKQLHEEVNLLK 183
+N +++L EN L E +L V LK
Sbjct: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESLK 714
Score = 45.8 bits (107), Expect = 4e-05
Identities = 54/256 (21%), Positives = 117/256 (45%), Gaps = 27/256 (10%)
Query: 9 HQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDN 68
H+S+K+ +L + EKR+ ++ + K GE +EL+ L ++ +N
Sbjct: 593 HESIKETSSKL----SKIEFEKRQ-------IKKELEHYKEKGERAEELENELHHLEKEN 641
Query: 69 KLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKE 128
+LL+ I ++ E I A E+E+ +LER +++ + +L+ +++
Sbjct: 642 ELLQKKITNLKITCEKI-----EALEQEN--SELERENRKLKKTLDSFKNLTFQLESLEK 694
Query: 129 ERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAK 188
E S ++ N EL + + + + L +EN+ L+ +QL + + LLK++ K
Sbjct: 695 ENSQLDEE----NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKK 750
Query: 189 YKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSE--DHGCSLPATPQSISDLKSLAT 246
+ + + + L S K++Q L SE D +++ +LK +++
Sbjct: 751 TERLEVSYQGLDIENQRLQKTLEN--SNKKIQQLESELQDLEMENQTLQKNLEELK-ISS 807
Query: 247 ALLETIHEKNMVIQHQ 262
LE + ++N ++ +
Sbjct: 808 KRLEQLEKENKSLEQE 823
Score = 38.5 bits (88), Expect = 0.006
Identities = 35/193 (18%), Positives = 86/193 (44%), Gaps = 6/193 (3%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEV 64
L+ H++L+ ++R+L D L +K + +L ++L+ Q++ + + + ++
Sbjct: 1184 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKL 1243
Query: 65 QGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQ 124
G+N L T ++ E + H ++L L +K + LE + ++ Q
Sbjct: 1244 CGENDRLNHTYSQLLKETEVLQTDH------KNLKSLLNNSKLEQTRLEAEFSKLKEQYQ 1297
Query: 125 DVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKS 184
+ + ++ E L+Q ++ + + + + L ++NR L E+ + + ++ +
Sbjct: 1298 QLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQR 1357
Query: 185 NIAKYKNALERRK 197
N L R+K
Sbjct: 1358 QYIDKLNELRRQK 1370
Score = 38.1 bits (87), Expect = 0.008
Identities = 40/206 (19%), Positives = 87/206 (42%), Gaps = 14/206 (6%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHL-------GEEIKE 56
QL+ ++ L+ + +L G L +K L + N+ L ++I++
Sbjct: 722 QLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ 781
Query: 57 LQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDL 116
L+ L +++ +N+ L+ + + ++ + + E QLE+ K+Q+E L
Sbjct: 782 LESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
Query: 117 QASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQER----- 171
+ + EE + +E+ N+ L+ + ++ + + L EN+ L +R
Sbjct: 842 RQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDI 901
Query: 172 --LKQLHEEVNLLKSNIAKYKNALER 195
L L E++ K + N LE+
Sbjct: 902 KTLVTLREDLVSEKLKTQQMNNDLEK 927
Score = 35.0 bits (79), Expect = 0.068
Identities = 55/268 (20%), Positives = 110/268 (41%), Gaps = 34/268 (12%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPEKRKQANL-AQLLRDS---QDRNKHLGEEIKELQQR 60
L+E++ +L+ + +L + +L + N AQLL ++ N+ + +E ++L+
Sbjct: 1093 LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSL 1152
Query: 61 LGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASV 120
+ D++ L + +Q A E E L+ + K ++LE + +
Sbjct: 1153 YDSLIKDHEKLELLHERQ-------------ASEYESLISKHGTLKSAHKNLEVEHRDLE 1199
Query: 121 DELQDVKEERSSYQDKVERLNQELNHIL---SGHENRIIDVDALCMENRYLQERLKQLHE 177
D + +++ +D + L E +L HE + LC EN L QL +
Sbjct: 1200 DRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK 1259
Query: 178 EVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQS 237
E +L+++ K+ L K + + ++ S L +Q Q L T
Sbjct: 1260 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKL-----KEQYQ---------QLDITSTK 1305
Query: 238 ISDLKSLATALLETIHEKNMVIQHQRQT 265
+++ L + L + E+N + Q QT
Sbjct: 1306 LNNQCELLSQLKGNLEEENRHLLDQIQT 1333
Score = 33.5 bits (75), Expect = 0.20
Identities = 52/271 (19%), Positives = 118/271 (43%), Gaps = 38/271 (14%)
Query: 6 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQ------- 58
+ R + LK+ + L++ L + + L + + N L ++ +++
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDR 402
Query: 59 QRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQA 118
+++ E+ +N L M A+++ DE++ H +L +Q+ R E E+ + L
Sbjct: 403 KKIEELMEENMTLEM--AQKQSMDESL-------HLGWEL-EQISRTSELSEAPQKSLGH 452
Query: 119 SVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEE 178
V+EL SS K+E NQ L + + V+ + +++ ++L ++
Sbjct: 453 EVNELT------SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506
Query: 179 VNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVL------SAKQVQDLLSEDHGCSLP 232
V +L++ I + K +L+ +N + L + S +Q++ L E+ +
Sbjct: 507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN-- 564
Query: 233 ATPQSISDLKS----LATALLETIHEKNMVI 259
Q++S L+ A A ++ I ++N ++
Sbjct: 565 ---QTVSSLRQRSQISAEARVKDIEKENKIL 592
Score = 30.4 bits (67), Expect = 1.7
Identities = 38/180 (21%), Positives = 74/180 (41%), Gaps = 15/180 (8%)
Query: 7 ERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQG 66
+R +S + EL D + +++ + L D + + + E+K LQQ +
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 67 DNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDV 126
D + RM DE +R A + L ++ R KE++ HD++ ++++
Sbjct: 301 DARSARM------YRDELDALREKAVRV-DKLESEVSRYKERL----HDIEFYKARVEEL 349
Query: 127 KEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNI 186
KE+ + L + L G R + L EN L+ +L + E ++ + I
Sbjct: 350 KEDNQVLLETKTMLEDQ----LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKI 405
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 52.4 bits (124), Expect = 4e-07
Identities = 36/154 (23%), Positives = 75/154 (48%), Gaps = 11/154 (7%)
Query: 30 KRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRH 89
+R Q + ++D + NK L E IKE +L +++ + + ++ + + E
Sbjct: 572 QRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE------ 625
Query: 90 FAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILS 149
A E E+ + LE+ E ++ +L+ + ++++ +++E S ++ER N++L L
Sbjct: 626 -RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENS----ELERENRKLKKTLD 680
Query: 150 GHENRIIDVDALCMENRYLQERLKQLHEEVNLLK 183
+N +++L EN L E +L V LK
Sbjct: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESLK 714
Score = 45.8 bits (107), Expect = 4e-05
Identities = 54/256 (21%), Positives = 117/256 (45%), Gaps = 27/256 (10%)
Query: 9 HQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDN 68
H+S+K+ +L + EKR+ ++ + K GE +EL+ L ++ +N
Sbjct: 593 HESIKETSSKL----SKIEFEKRQ-------IKKELEHYKEKGERAEELENELHHLEKEN 641
Query: 69 KLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKE 128
+LL+ I ++ E I A E+E+ +LER +++ + +L+ +++
Sbjct: 642 ELLQKKITNLKITCEKI-----EALEQEN--SELERENRKLKKTLDSFKNLTFQLESLEK 694
Query: 129 ERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAK 188
E S ++ N EL + + + + L +EN+ L+ +QL + + LLK++ K
Sbjct: 695 ENSQLDEE----NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKK 750
Query: 189 YKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSE--DHGCSLPATPQSISDLKSLAT 246
+ + + + L S K++Q L SE D +++ +LK +++
Sbjct: 751 TERLEVSYQGLDIENQRLQKTLEN--SNKKIQQLESELQDLEMENQTLQKNLEELK-ISS 807
Query: 247 ALLETIHEKNMVIQHQ 262
LE + ++N ++ +
Sbjct: 808 KRLEQLEKENKSLEQE 823
Score = 38.5 bits (88), Expect = 0.006
Identities = 35/193 (18%), Positives = 86/193 (44%), Gaps = 6/193 (3%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEV 64
L+ H++L+ ++R+L D L +K + +L ++L+ Q++ + + + ++
Sbjct: 1183 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKL 1242
Query: 65 QGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQ 124
G+N L T ++ E + H ++L L +K + LE + ++ Q
Sbjct: 1243 CGENDRLNHTYSQLLKETEVLQTDH------KNLKSLLNNSKLEQTRLEAEFSKLKEQYQ 1296
Query: 125 DVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKS 184
+ + ++ E L+Q ++ + + + + L ++NR L E+ + + ++ +
Sbjct: 1297 QLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQR 1356
Query: 185 NIAKYKNALERRK 197
N L R+K
Sbjct: 1357 QYIDKLNELRRQK 1369
Score = 38.1 bits (87), Expect = 0.008
Identities = 40/206 (19%), Positives = 87/206 (42%), Gaps = 14/206 (6%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHL-------GEEIKE 56
QL+ ++ L+ + +L G L +K L + N+ L ++I++
Sbjct: 722 QLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ 781
Query: 57 LQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDL 116
L+ L +++ +N+ L+ + + ++ + + E QLE+ K+Q+E L
Sbjct: 782 LESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
Query: 117 QASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQER----- 171
+ + EE + +E+ N+ L+ + ++ + + L EN+ L +R
Sbjct: 842 RQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDI 901
Query: 172 --LKQLHEEVNLLKSNIAKYKNALER 195
L L E++ K + N LE+
Sbjct: 902 KTLVTLREDLVSEKLKTQQMNNDLEK 927
Score = 36.6 bits (83), Expect = 0.024
Identities = 54/226 (23%), Positives = 99/226 (43%), Gaps = 41/226 (18%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQL-----------LRDSQDRNKHLGE 52
QL + ++SL+++ +L L E ++ A++ + + + NK L +
Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 53 EI---KELQQRLGEVQGDNKLL--RMTI-------AKQRLGDEAIGVRHFAAHEREDLVQ 100
EI KE RL E++ +NK L R TI ++ L E + + ++ E L
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN-NDLEKLTH 930
Query: 101 QLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDA 160
+LE+ E L HD Q++ D Y+ +L L L E +I ++A
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDR----------YKLLESKLESTLKKSLEIKEEKIAALEA 980
Query: 161 LCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSS 206
E+ ++L+Q E+ +K N AL++R++ + +SS
Sbjct: 981 RLEESTNYNQQLRQ---ELKTVKKNY----EALKQRQDEERMVQSS 1019
Score = 35.0 bits (79), Expect = 0.068
Identities = 55/268 (20%), Positives = 110/268 (41%), Gaps = 34/268 (12%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPEKRKQANL-AQLLRDS---QDRNKHLGEEIKELQQR 60
L+E++ +L+ + +L + +L + N AQLL ++ N+ + +E ++L+
Sbjct: 1092 LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSL 1151
Query: 61 LGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASV 120
+ D++ L + +Q A E E L+ + K ++LE + +
Sbjct: 1152 YDSLIKDHEKLELLHERQ-------------ASEYESLISKHGTLKSAHKNLEVEHRDLE 1198
Query: 121 DELQDVKEERSSYQDKVERLNQELNHIL---SGHENRIIDVDALCMENRYLQERLKQLHE 177
D + +++ +D + L E +L HE + LC EN L QL +
Sbjct: 1199 DRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK 1258
Query: 178 EVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQS 237
E +L+++ K+ L K + + ++ S L +Q Q L T
Sbjct: 1259 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKL-----KEQYQ---------QLDITSTK 1304
Query: 238 ISDLKSLATALLETIHEKNMVIQHQRQT 265
+++ L + L + E+N + Q QT
Sbjct: 1305 LNNQCELLSQLKGNLEEENRHLLDQIQT 1332
Score = 33.5 bits (75), Expect = 0.20
Identities = 52/271 (19%), Positives = 118/271 (43%), Gaps = 38/271 (14%)
Query: 6 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQ------- 58
+ R + LK+ + L++ L + + L + + N L ++ +++
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDR 402
Query: 59 QRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQA 118
+++ E+ +N L M A+++ DE++ H +L +Q+ R E E+ + L
Sbjct: 403 KKIEELMEENMTLEM--AQKQSMDESL-------HLGWEL-EQISRTSELSEAPQKSLGH 452
Query: 119 SVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEE 178
V+EL SS K+E NQ L + + V+ + +++ ++L ++
Sbjct: 453 EVNELT------SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506
Query: 179 VNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVL------SAKQVQDLLSEDHGCSLP 232
V +L++ I + K +L+ +N + L + S +Q++ L E+ +
Sbjct: 507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN-- 564
Query: 233 ATPQSISDLKS----LATALLETIHEKNMVI 259
Q++S L+ A A ++ I ++N ++
Sbjct: 565 ---QTVSSLRQRSQISAEARVKDIEKENKIL 592
Score = 30.4 bits (67), Expect = 1.7
Identities = 38/180 (21%), Positives = 74/180 (41%), Gaps = 15/180 (8%)
Query: 7 ERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQG 66
+R +S + EL D + +++ + L D + + + E+K LQQ +
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 67 DNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDV 126
D + RM DE +R A + L ++ R KE++ HD++ ++++
Sbjct: 301 DARSARM------YRDELDALREKAVRV-DKLESEVSRYKERL----HDIEFYKARVEEL 349
Query: 127 KEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNI 186
KE+ + L + L G R + L EN L+ +L + E ++ + I
Sbjct: 350 KEDNQVLLETKTMLEDQ----LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKI 405
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 52.4 bits (124), Expect = 4e-07
Identities = 45/217 (20%), Positives = 101/217 (46%), Gaps = 25/217 (11%)
Query: 7 ERHQSLKKKYRELIDGDPSLPPEKRKQANLAQL-LRDSQDRNKHLGEEIKELQQRLGEVQ 65
E+ Q L+++Y++ I+ +K KQ +L + + + +++ K L ++E + ++ +++
Sbjct: 248 EKIQHLEQEYKKEIN-------DKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE 300
Query: 66 GDNKL----LRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVD 121
KL L+ +I KQ H E ED+ L+R+ ++LE DLQ +
Sbjct: 301 EKTKLQSENLKQSIEKQ----------HHLTKELEDIKVSLQRSVSTQKALEEDLQIATK 350
Query: 122 ELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNL 181
+ + EE+ + ++ + + +++ E + ++ L R Q+RL++ +++ +
Sbjct: 351 TICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELL---RTEQQRLEKNEDQLKI 407
Query: 182 LKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQ 218
L + K + LE + L VL K+
Sbjct: 408 LTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKE 444
Score = 44.7 bits (104), Expect = 9e-05
Identities = 46/211 (21%), Positives = 99/211 (46%), Gaps = 15/211 (7%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGE 63
Q + + LK +ELI L +++ +L L ++ +E+K+L+ L
Sbjct: 452 QFEKIAEELKGTEQELIG---LLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELEN 508
Query: 64 VQGDNKLL-----RMTIAKQRLGDEAIGVRHFAAHEREDL---VQQLERAKEQIESLEHD 115
+ N L ++++ + L E + +++ED+ +Q ER +QIE+L+
Sbjct: 509 EKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQET 568
Query: 116 LQASVDELQDVKEERSSYQD----KVERLNQELNHILSGHENRIIDVDALCMENRYLQER 171
+EL+ V+EE +D K+++ + N++ EN+ ++ L EN+ L+++
Sbjct: 569 ETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKK 628
Query: 172 LKQLHEEVNLLKSNIAKYKNALERRKNSKGQ 202
+++N+ + + K + LE K G+
Sbjct: 629 GTAESKQLNVYEIKVNKLELELESAKQKFGE 659
Score = 42.4 bits (98), Expect = 4e-04
Identities = 53/255 (20%), Positives = 111/255 (43%), Gaps = 39/255 (15%)
Query: 35 NLAQLLRDSQDRNKHLGEEIK----ELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHF 90
+L +LLR Q R + +++K ELQ++ E++ KL + + +G +
Sbjct: 386 SLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKET 445
Query: 91 AAHEREDLVQQLERAKEQIESLEHDL----QASVDELQDVKEERSS-------YQDKVER 139
+E + Q E+ E+++ E +L QA E+ D++ + ++ Y +V+
Sbjct: 446 LLYENK----QFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKD 501
Query: 140 LNQEL------NHILSGHENRI-IDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNA 192
L EL N L+ H N++ ++ L E + LK E++N K +
Sbjct: 502 LKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQ 561
Query: 193 LERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETI 252
+E + ++ Q ++ + L K+ ++ C L + ++ ++L+ + +
Sbjct: 562 IENLQETETQLRNELEYVREELKQKR------DEVKCKLDKSEENCNNLR-------KQV 608
Query: 253 HEKNMVIQHQRQTNK 267
KN I+ +Q NK
Sbjct: 609 ENKNKYIEELQQENK 623
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 52.4 bits (124), Expect = 4e-07
Identities = 61/257 (23%), Positives = 109/257 (42%), Gaps = 39/257 (15%)
Query: 30 KRKQANLAQLLRDSQDRNKHLGEEIKEL-------QQRLGEVQGDNKLLRMTIAKQRLGD 82
K KQA LAQ L+ + ++ L ++++L +Q+L EV + R A+Q
Sbjct: 529 KEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLAT- 587
Query: 83 EAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVD----ELQDVKEERSSYQDKVE 138
AA ERE +++ + A +Q+E+LE + A ++ +LQ E R S Q V
Sbjct: 588 --------AAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVT 639
Query: 139 RLNQELNHILSGHENRIIDVDALCMENRYLQERLKQL------HEEVNLLKSNIAKYKNA 192
+ +E + E V+ E Q ++ +L ++ K +A+ K+
Sbjct: 640 QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQ 699
Query: 193 LERRKNSKGQGKSSSSALTGVL--SAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLE 250
L+ + + K S G L ++ D L E C IS+LK+ +L+E
Sbjct: 700 LQEQLQAL---KESLKVTKGSLEEEKRRAADALEEQQRC--------ISELKAETRSLVE 748
Query: 251 TIHEKNMVIQHQRQTNK 267
+ ++ +R K
Sbjct: 749 QHKRERKELEEERAGRK 765
Score = 44.3 bits (103), Expect = 1e-04
Identities = 68/304 (22%), Positives = 133/304 (43%), Gaps = 65/304 (21%)
Query: 3 NQLRERHQSLKKKYRELIDGDPSLPPEKRKQAN--------LAQLLRDSQDRNKHLGEEI 54
+QL+E+ Q+LK+ + SL EKR+ A+ +++L +++ + E
Sbjct: 698 DQLQEQLQALKESLKVT---KGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRER 754
Query: 55 KELQ-------------QRLGEV-QGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQ 100
KEL+ Q+LGE Q + ++LR +A EA+ +H A E E LV+
Sbjct: 755 KELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA------EAMAAQHTAESECEQLVK 808
Query: 101 QL------------ERAK------EQIESLEHDLQASVDELQDVKEERSSYQDKVE-RLN 141
++ E A+ EQ+ +L+ + + + ELQ+ KE+ + + E +++
Sbjct: 809 EVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQIS 868
Query: 142 QELNHILSGHEN---RIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKN 198
++ N + H N + V + + L + L L E++ +A+ + L R+
Sbjct: 869 RQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLE-TLVRKAG 927
Query: 199 SKGQGKSSSSALTGVLSAKQVQDLLSEDHG---CSLPATPQSI--------SDLKSLATA 247
+ + S + + + L E G CS A Q++ ++L+ L A
Sbjct: 928 EQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAA 987
Query: 248 LLET 251
L+E+
Sbjct: 988 LMES 991
Score = 39.7 bits (91), Expect = 0.003
Identities = 43/201 (21%), Positives = 93/201 (46%), Gaps = 22/201 (10%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPE-KRKQANLAQLLRDS--------QDRNKHLGEEIK 55
LRER +LK+ E ++ + + E ++Q +A RDS Q L +++
Sbjct: 596 LRERDAALKQL--EALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVE 653
Query: 56 ELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHD 115
ELQ + + + + +A+ L + A E+E + Q+ ++ +EQ+++L+
Sbjct: 654 ELQACVETARQEQHEAQAQVAELEL---QLRSEQQKATEKERVAQEKDQLQEQLQALKES 710
Query: 116 LQASVDELQDVKEERSSYQDKVER----LNQELNHILSGHENRIIDVDALCMENRYLQER 171
L+ + L++ K + ++ +R L E ++ H+ +++ + L+ R
Sbjct: 711 LKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEAR 770
Query: 172 LKQLHE----EVNLLKSNIAK 188
L+QL E E +L+ +A+
Sbjct: 771 LQQLGEAHQAETEVLRRELAE 791
Score = 39.3 bits (90), Expect = 0.004
Identities = 47/192 (24%), Positives = 87/192 (45%), Gaps = 16/192 (8%)
Query: 36 LAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHER 95
L + L D + L E+ E ++ L E K ++ + +QR+ A+ AA
Sbjct: 219 LKKQLADERSNRDELELELAENRKLLTE-----KDAQIAMMQQRIDRLALLNEKQAASPL 273
Query: 96 EDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRI 155
E ++LE +++ ESL L ++ + QD+K E+S K+ +L++E N LS
Sbjct: 274 EP--KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEE-NGDLS------ 324
Query: 156 IDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLS 215
+ + LQ+ L +L EE + + + LE+ ++ Q K +L
Sbjct: 325 FKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQ 384
Query: 216 AK--QVQDLLSE 225
K Q+++ LS+
Sbjct: 385 GKLSQLEEHLSQ 396
Score = 36.6 bits (83), Expect = 0.024
Identities = 48/206 (23%), Positives = 91/206 (44%), Gaps = 46/206 (22%)
Query: 2 ANQLRERHQSLKKKYRELIDGDPSLPPEKRKQA--NLAQLLRDSQDRNKHLGEEIKELQQ 59
++ LRE QSL+++ EK++ A NL Q L +R + LG+E+K Q+
Sbjct: 1287 SSALREEVQSLREE------------AEKQRVASENLRQELTSQAERAEELGQELKAWQE 1334
Query: 60 RLGEVQGDNKLLRMT-IAKQRLGDEAIGVRHF---------AAHEREDLVQQLERAKEQI 109
+ + + L++ + Q L E + +H AA +R ++LE++K+
Sbjct: 1335 KFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR--EELEQSKQAA 1392
Query: 110 ESLEHDLQASVDEL-----------------QDVKEERSSYQDKVERLNQELNHILSGHE 152
L +L + EL Q ++ E++SY +++ L + H L E
Sbjct: 1393 GGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKA--HGLLAEE 1450
Query: 153 NRIIDVDALCMENRYLQERLKQLHEE 178
NR + + + ++L+ L Q E+
Sbjct: 1451 NRGLG-ERANLGRQFLEVELDQAREK 1475
Score = 35.4 bits (80), Expect = 0.052
Identities = 46/228 (20%), Positives = 95/228 (41%), Gaps = 12/228 (5%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGE 63
+L E Q++K+ +L + Q+ A + + + L E+ +L+Q+ +
Sbjct: 1079 ELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQK 1138
Query: 64 VQGDNKLLRMTIAKQRLGD-EAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDE 122
Q L ++ +R E + E+ Q+L ++ + S + +L A +
Sbjct: 1139 QQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTK 1198
Query: 123 LQDVKEERSSYQDKVERLNQEL---NHILSGHENRIIDVDALCMENRYLQERLKQLHEEV 179
+QD + ++ +V R QE N ++S E + + NR + E+ + E
Sbjct: 1199 VQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEV------SILNRQVLEKEGESKELK 1252
Query: 180 NLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSA--KQVQDLLSE 225
L+ + K + ER + + + S+S+ SA ++VQ L E
Sbjct: 1253 RLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREE 1300
Score = 35.0 bits (79), Expect = 0.068
Identities = 64/303 (21%), Positives = 113/303 (37%), Gaps = 51/303 (16%)
Query: 3 NQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDS----QDRNKHLGEEIKELQ 58
N+L E H K +E ++ L E + L + Q + L E + +LQ
Sbjct: 342 NELTEEHS---KATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQ 398
Query: 59 ----QRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAH-----------EREDLVQQ-- 101
Q GEV GD +L++ KQ A A E + L ++
Sbjct: 399 DNPPQEKGEVLGD--VLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGH 456
Query: 102 LERAKEQIESLEHDLQASVDELQDVKEER---------------SSYQDKVERLN---QE 143
E K+Q+ SL DLQ+S+ L KEE +S ++ LN Q+
Sbjct: 457 FEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQ 516
Query: 144 LNHILSGHENRIIDVDALCMENRYLQERLKQ-LHEEVNLLKSNIAKYKNALERRKNSKGQ 202
+ L+G + + + A + QE+ Q L +V L S++ + + L+ +
Sbjct: 517 QDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEA 576
Query: 203 GKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQ 262
+ + + ++ L D A + + L+ A LE + ++ V
Sbjct: 577 TRQDHAQQLATAAEEREASLRERD------AALKQLEALEKEKAAKLEILQQQLQVANEA 630
Query: 263 RQT 265
R +
Sbjct: 631 RDS 633
Score = 35.0 bits (79), Expect = 0.068
Identities = 50/213 (23%), Positives = 85/213 (39%), Gaps = 35/213 (16%)
Query: 34 ANLAQLLRDSQD---RNKHLGEEIKELQQRLG----EVQGDNKLLRMTIAKQRLGDEAIG 86
ANLA+ L+ Q+ R + L +++ LQ+++ EV L+R +Q +
Sbjct: 879 ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELV 938
Query: 87 VRHFAAHERED----------------LVQQLERAKEQIESLEHDLQASVDELQ-DVKEE 129
A +R+ +Q +ER EQ+ + L+A++ E Q +EE
Sbjct: 939 KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEE 998
Query: 130 RSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKY 189
R + +V RL QE + L +E E +L +N + A
Sbjct: 999 RGQQEREVARLTQERGRAQAD----------LALEKAARAELEMRLQNALNEQRVEFATL 1048
Query: 190 KNALERRKNSKGQGKSSSSALTGVLSAKQVQDL 222
+ AL K +GK A L A Q+++L
Sbjct: 1049 QEALAHALTEK-EGKDQELAKLRGLEAAQIKEL 1080
Score = 33.9 bits (76), Expect = 0.15
Identities = 26/145 (17%), Positives = 71/145 (48%), Gaps = 4/145 (2%)
Query: 6 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQ 65
RE+ + +++ ++L D D + +++K + +SQ + L ++ ELQ +L + +
Sbjct: 1545 REQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKE 1604
Query: 66 GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQI----ESLEHDLQASVD 121
+ ++ + K + +A ++ E+ ++QL++ +++ E L H+LQ +
Sbjct: 1605 QAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGL 1664
Query: 122 ELQDVKEERSSYQDKVERLNQELNH 146
+ ++ ++ +V L ++ H
Sbjct: 1665 KTKEAEQTCRHLTAQVRSLEAQVAH 1689
Score = 33.1 bits (74), Expect = 0.26
Identities = 61/264 (23%), Positives = 106/264 (40%), Gaps = 45/264 (17%)
Query: 2 ANQLRERHQSLKKKYRELIDGDPSLPPEKR---KQANLAQLLRD---SQDRNKHLGEEIK 55
A QLR S ++ L L E R ++ANL + + Q R K++ E
Sbjct: 1423 AQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAA 1482
Query: 56 ---ELQQRLGEVQGD-----NKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAK- 106
+ + RL EVQ + +L MT + + + R ER+ L Q+E+ +
Sbjct: 1483 VRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEV 1542
Query: 107 ------EQIESLEHDL----QASV---DELQDVKEERSSYQDKVERLNQELN-------- 145
+Q+E L L QAS +L+ V+ + Q + +RL +LN
Sbjct: 1543 FQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ 1602
Query: 146 ------HILSGHENRIIDVDALCMENRYLQERLK---QLHEEVNLLKSNIAKYKNALERR 196
H E DA +N+ LQE+L+ QL +E L++ + + L++
Sbjct: 1603 KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQA 1662
Query: 197 KNSKGQGKSSSSALTGVLSAKQVQ 220
+ + + LT + + + Q
Sbjct: 1663 GLKTKEAEQTCRHLTAQVRSLEAQ 1686
Score = 31.2 bits (69), Expect = 0.99
Identities = 31/126 (24%), Positives = 60/126 (47%), Gaps = 4/126 (3%)
Query: 25 SLPPEKRKQANLAQL--LRDSQDRN-KHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLG 81
+L ++ K LA+L L +Q + + L + +K+L+++L + + ++ ++
Sbjct: 1055 ALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGR 1114
Query: 82 DEAIGVRHFAAH-EREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERL 140
E G + A E L QQ ++ +EQ +SLE L+A + + Q ++E
Sbjct: 1115 TEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEK 1174
Query: 141 NQELNH 146
QEL H
Sbjct: 1175 AQELGH 1180
>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
sapiens]
Length = 693
Score = 52.0 bits (123), Expect = 5e-07
Identities = 56/225 (24%), Positives = 100/225 (44%), Gaps = 19/225 (8%)
Query: 8 RHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGD 67
R Q L++ EL + PP A + ++ QD KHL +E++ L+ +L +
Sbjct: 267 RIQELERSLSEL-KNQMAKPPSLAPPA-VTSVVEQLQDEAKHLRQEVEGLEGKLQSQVEN 324
Query: 68 NKLLRMTIA--KQRLGDEAIGVRHFAAH---EREDLVQQLERAKEQIESLEHDLQASVDE 122
N+ L + KQRL ++ +R E+E L +Q ER +EQ ++L+ + +
Sbjct: 325 NQALSLLSKEQKQRLQEQEEMLREQEVQRVREQERLCEQNERLREQQKTLQEQGERLRKQ 384
Query: 123 LQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLL 182
Q ++++ + + ERL ++ E R+ D + E + +E Q EE L
Sbjct: 385 EQRLRKQEERLRKEEERLQKQ--------EKRLWDQE----ERLWKKEERLQKQEERLAL 432
Query: 183 KSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDH 227
N K E + + + SAL K++Q+ L E+H
Sbjct: 433 SQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEH 477
Score = 42.4 bits (98), Expect = 4e-04
Identities = 43/193 (22%), Positives = 91/193 (47%), Gaps = 27/193 (13%)
Query: 13 KKKYRELIDGDPSLPPEKR-KQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLL 71
+ +Y + I G+ + E+ K + A+ L++ + R+ H I+EL++ L E++ N++
Sbjct: 229 RDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIH---RIQELERSLSELK--NQMA 283
Query: 72 RMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDV----K 127
+ L A+ E L + + ++++E LE LQ+ V+ Q + K
Sbjct: 284 K----PPSLAPPAV------TSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSK 333
Query: 128 EERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIA 187
E++ Q++ E L ++ R+ + + LC +N L+E+ K L E+ L+
Sbjct: 334 EQKQRLQEQEEMLREQ-------EVQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQ 386
Query: 188 KYKNALERRKNSK 200
+ + ER + +
Sbjct: 387 RLRKQEERLRKEE 399
Score = 32.0 bits (71), Expect = 0.58
Identities = 36/146 (24%), Positives = 70/146 (47%), Gaps = 10/146 (6%)
Query: 6 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQ 65
+E+ Q L+++ L + + E+ + + LR+ Q + GE +++ +QRL + +
Sbjct: 333 KEQKQRLQEQEEMLREQEVQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQE 392
Query: 66 GDNKLLRMTIAKQ--RLGDEAIGVRHFAAHEREDLVQQLER-AKEQIESLEHDL---QAS 119
+ + KQ RL D+ R + ER L +Q ER A Q L+ L Q S
Sbjct: 393 ERLRKEEERLQKQEKRLWDQE--ERLWKKEER--LQKQEERLALSQNHKLDKQLAEPQCS 448
Query: 120 VDELQDVKEERSSYQDKVERLNQELN 145
++L + K+ + +V+ L ++L+
Sbjct: 449 FEDLNNEKKSALQLEQQVKELQEKLD 474
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 50.4 bits (119), Expect = 2e-06
Identities = 56/238 (23%), Positives = 109/238 (45%), Gaps = 17/238 (7%)
Query: 3 NQLRERHQSLKKKYRELIDGDP----SLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQ 58
N+LR+ LK L+D L + +K +L Q LR+ +++ K + + KE +
Sbjct: 234 NKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDR 293
Query: 59 QRL--GEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDL 116
Q+L EV ++K R + + + + R LV +R E++E +L
Sbjct: 294 QKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRI-EELEETNKNL 352
Query: 117 QASVDELQDVKEE-------RSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQ 169
Q + +ELQ+++++ SS +VE L + + + G + I ++ C E R
Sbjct: 353 QKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLE-MEGKDEEITKTESQCRELRKKL 411
Query: 170 ERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQ--VQDLLSE 225
+ + +E+ L + K + LE+ + + + KS + L L ++ +DLL+E
Sbjct: 412 QEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNE 469
Score = 46.2 bits (108), Expect = 3e-05
Identities = 36/173 (20%), Positives = 79/173 (45%), Gaps = 3/173 (1%)
Query: 31 RKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHF 90
R++ L L+ ++++ L + L++RL ++ + +T + R G E
Sbjct: 570 RERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVER--EITRGRSRKGSELTCPEDN 627
Query: 91 AAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSG 150
E +++L++ +Q+E +E DL + DE ++++ + QDK L+Q+L I
Sbjct: 628 KIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQ 687
Query: 151 -HENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQ 202
+N+ I+ + + L+ R + + LK+ + K + N + Q
Sbjct: 688 IAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQ 740
Score = 43.9 bits (102), Expect = 1e-04
Identities = 43/189 (22%), Positives = 84/189 (44%), Gaps = 18/189 (9%)
Query: 32 KQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFA 91
K + LL ++R K L E+ K Q R E + +L +L DE + ++ FA
Sbjct: 196 KSDDFTNLLEQERERLKKLLEQEKAYQARK-EKENAKRL-------NKLRDELVKLKSFA 247
Query: 92 ---AHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHIL 148
ER+ ++QL ++++ L L+ ++L+ + + + K+ +L + H
Sbjct: 248 LMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKA 307
Query: 149 S--GHENRIIDVDALCMENRYLQERLK-----QLHEEVNLLKSNIAKYKNALERRKNSKG 201
S E+ ++ E+ Q RLK Q EE+ N+ K + L+ ++
Sbjct: 308 SRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIA 367
Query: 202 QGKSSSSAL 210
+G+ +S+L
Sbjct: 368 KGECGNSSL 376
Score = 38.9 bits (89), Expect = 0.005
Identities = 43/213 (20%), Positives = 99/213 (46%), Gaps = 25/213 (11%)
Query: 2 ANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRL 61
+ +LR + L+K+ EL + + K + L L ++ K L E++ ++ R+
Sbjct: 418 SKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRV 477
Query: 62 GEVQGDNKLLRMTIAKQRLGDEAIGVRHFAA---HEREDLVQQLERAKEQIESLEHDLQA 118
E++ R+ A+ L D+ ++ F ER+++++++++ + +++ L
Sbjct: 478 KELECSES--RLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLN----- 530
Query: 119 SVDELQDVKEERSSYQDKVERLNQELNHIL---SGHENRIIDV----DALCMENRYLQER 171
++ K E+ D E+L +E +L S E ++ ++ D L + + +E+
Sbjct: 531 -----KNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEK 585
Query: 172 LKQLHEEVNLLK---SNIAKYKNALERRKNSKG 201
+L V+LLK I + + + R ++ KG
Sbjct: 586 SSELSCSVDLLKKRLDGIEEVEREITRGRSRKG 618
Score = 36.6 bits (83), Expect = 0.024
Identities = 20/81 (24%), Positives = 45/81 (55%)
Query: 2 ANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRL 61
+ L+ Q+LK+K EL++ + L + + L Q + +++NK++G+E+ L + L
Sbjct: 717 SRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKEL 776
Query: 62 GEVQGDNKLLRMTIAKQRLGD 82
+ ++ LR ++ +R+ D
Sbjct: 777 ELSKRYSRALRPSVNGRRMVD 797
Score = 36.2 bits (82), Expect = 0.031
Identities = 55/258 (21%), Positives = 110/258 (42%), Gaps = 57/258 (22%)
Query: 10 QSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNK 69
+ LKK+ ++L + L + + L Q R QD+ L ++++E++ ++ + NK
Sbjct: 637 ERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAK----NK 692
Query: 70 LLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEE 129
I K + + +RH +LE AK + DL+A E+Q +KE+
Sbjct: 693 ----AIEKGEVVSQEAELRHRF---------RLEEAKSR------DLKA---EVQALKEK 730
Query: 130 RSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLH---EEVNLLKSNI 186
+K ++L+Q + VD ++ R+++E K + E +NL K
Sbjct: 731 IHELMNKEDQLSQ-------------LQVDYSVLQQRFMEEENKNKNMGQEVLNLTKE-- 775
Query: 187 AKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLAT 246
LE K S AL ++ +++ D+ G A ++ ++ A
Sbjct: 776 ------LE-------LSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAV 822
Query: 247 ALLETIHEKNMVIQHQRQ 264
+ ++ E+N ++ + RQ
Sbjct: 823 FIRKSFQEENHIMSNLRQ 840
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 50.1 bits (118), Expect = 2e-06
Identities = 51/222 (22%), Positives = 100/222 (45%), Gaps = 26/222 (11%)
Query: 1 MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKE-LQQ 59
++N++ E+ + L + RE + KR+ N+ L +H E++K L+Q
Sbjct: 626 LSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEH--EQVKSRLEQ 683
Query: 60 RLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQAS 119
+ GE+ K+ +T+ Q L E E + + KEQ +L +++
Sbjct: 684 KSGEL--GKKITELTLKNQTLQKEI-----------EKVYLDNKLLKEQAHNLTIEMKNH 730
Query: 120 VDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQL---- 175
L+ ++ + S+ ++ LN++L + + + ++++ L +EN L + + +L
Sbjct: 731 YVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF 790
Query: 176 -----HE-EVNLLKSNIAKYKNALERRKNSKGQGKSSSSALT 211
HE E+ LKSNI + K L K G+ + ALT
Sbjct: 791 VPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALT 832
Score = 31.6 bits (70), Expect = 0.76
Identities = 41/179 (22%), Positives = 78/179 (43%), Gaps = 12/179 (6%)
Query: 88 RHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHI 147
R+ + E V+ +R + I+ LE + + + L+ +++E+ DKV L +LN
Sbjct: 262 RNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLN-- 319
Query: 148 LSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALER-RKNSKGQGKSS 206
++ D L E L+ L ++ I KN + + G G
Sbjct: 320 -----EEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHF 374
Query: 207 SSALTGVLSAKQVQDLLSEDHGCS--LPATPQSISDLKSLATAL-LETIHEKNMVIQHQ 262
S+ +L KQ Q +++ S +PA QS S L+ L +L +T + +N +++ +
Sbjct: 375 SNRKEDML-LKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKE 432
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 50.1 bits (118), Expect = 2e-06
Identities = 51/222 (22%), Positives = 100/222 (45%), Gaps = 26/222 (11%)
Query: 1 MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKE-LQQ 59
++N++ E+ + L + RE + KR+ N+ L +H E++K L+Q
Sbjct: 639 LSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEH--EQVKSRLEQ 696
Query: 60 RLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQAS 119
+ GE+ K+ +T+ Q L E E + + KEQ +L +++
Sbjct: 697 KSGEL--GKKITELTLKNQTLQKEI-----------EKVYLDNKLLKEQAHNLTIEMKNH 743
Query: 120 VDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQL---- 175
L+ ++ + S+ ++ LN++L + + + ++++ L +EN L + + +L
Sbjct: 744 YVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF 803
Query: 176 -----HE-EVNLLKSNIAKYKNALERRKNSKGQGKSSSSALT 211
HE E+ LKSNI + K L K G+ + ALT
Sbjct: 804 VPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALT 845
Score = 31.6 bits (70), Expect = 0.76
Identities = 41/179 (22%), Positives = 78/179 (43%), Gaps = 12/179 (6%)
Query: 88 RHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHI 147
R+ + E V+ +R + I+ LE + + + L+ +++E+ DKV L +LN
Sbjct: 275 RNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLN-- 332
Query: 148 LSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALER-RKNSKGQGKSS 206
++ D L E L+ L ++ I KN + + G G
Sbjct: 333 -----EEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHF 387
Query: 207 SSALTGVLSAKQVQDLLSEDHGCS--LPATPQSISDLKSLATAL-LETIHEKNMVIQHQ 262
S+ +L KQ Q +++ S +PA QS S L+ L +L +T + +N +++ +
Sbjct: 388 SNRKEDML-LKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKE 445
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 50.1 bits (118), Expect = 2e-06
Identities = 47/223 (21%), Positives = 102/223 (45%), Gaps = 9/223 (4%)
Query: 40 LRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHE-REDL 98
++D + R + + + L+++L + + + + L + QRL D+ G AHE +
Sbjct: 535 VQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQL--QRLRDKTDGAMQ--AHEDAQRE 590
Query: 99 VQQLERAKEQIE----SLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENR 154
VQ+L A E + +L H LQ + + +++++ER Q E L ++ + + E+
Sbjct: 591 VQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDA 650
Query: 155 IIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVL 214
+ D + E +L+QL + ++L + + + AL R + ++ + + L
Sbjct: 651 VQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEAL 710
Query: 215 SAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNM 257
+ + + E L A S+ D S +AL E++ + +
Sbjct: 711 TKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKL 753
Score = 48.9 bits (115), Expect = 5e-06
Identities = 63/285 (22%), Positives = 117/285 (41%), Gaps = 39/285 (13%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDS----QDRNKHLGEEI---KE 56
+LR SL+ +L + SL +K L L + Q R + +E +E
Sbjct: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVARE 785
Query: 57 LQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQL-------ERAKEQI 109
Q+RL E++ L +A+Q L G A +E L QQL + +EQ+
Sbjct: 786 EQERLEELR-----LEQEVARQGLE----GSLRVAEQAQEALEQQLPTLRHERSQLQEQL 836
Query: 110 ESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQ 169
L L EL+ + E + +ER +E + H + + A E R L
Sbjct: 837 AQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLS 896
Query: 170 ERLKQLHEEVNLLKSNIAKYKNAL----ERRKNSKGQGKS---SSSALTGVLSAKQVQDL 222
E +L E L+ ++ + + L RR+ + +G++ + LTG L+ + Q +
Sbjct: 897 EEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQII 956
Query: 223 LSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNK 267
+++ ++ D + +A L++ E ++ QR ++
Sbjct: 957 ATQE---------KASLDKELMAQKLVQAEREAQASLREQRAAHE 992
Score = 42.7 bits (99), Expect = 3e-04
Identities = 38/188 (20%), Positives = 81/188 (43%), Gaps = 10/188 (5%)
Query: 29 EKRKQANLAQLLRDSQDRNKHLGEEIKELQQR------LGEVQGDNKLLRMTIAKQRLGD 82
+ + Q +LL + + L EEI LQQ L E + L K L +
Sbjct: 1017 QSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSE 1076
Query: 83 EAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEER----SSYQDKVE 138
+ +G RH A ++ +Q A+ + E + A EL+D++ +R +++ +V
Sbjct: 1077 KLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR 1136
Query: 139 RLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKN 198
RL ++ + ++ + + + L + R L++ L E+ + + + + E ++
Sbjct: 1137 RLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQ 1196
Query: 199 SKGQGKSS 206
G+ + S
Sbjct: 1197 EAGELRRS 1204
Score = 37.0 bits (84), Expect = 0.018
Identities = 50/226 (22%), Positives = 98/226 (43%), Gaps = 23/226 (10%)
Query: 11 SLKKKYRELIDGDPSLP--PEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDN 68
SL RE++ + S P P +A LL L EE + LQQ L V+
Sbjct: 46 SLPALIREIVTRNLSQPESPVLLPATEMASLLS--------LQEENQLLQQELSRVED-- 95
Query: 69 KLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKE 128
+A+ R + + +++ A ER + +LE + + + ++ SV+ + ++E
Sbjct: 96 -----LLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQE 150
Query: 129 ERSSYQDKVERL---NQELNHILSGHENRIIDVDALCME-NRYLQERLKQLHEEVNLLKS 184
E++SY+ K++ Q ++ + +I+ C E + L ER +L ++
Sbjct: 151 EQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTE 210
Query: 185 NIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCS 230
+ ++AL R + Q +S+S A + +Q+ S + S
Sbjct: 211 HSQDLESALIRLEEE--QQRSASLAQVNAMLREQLDQAGSANQALS 254
Score = 37.0 bits (84), Expect = 0.018
Identities = 51/240 (21%), Positives = 98/240 (40%), Gaps = 42/240 (17%)
Query: 38 QLLRDSQDRNKHLGEEIKELQQRLG-------EVQGDNKLLRMTIAKQRLGDEAIGVRHF 90
Q L +++ ++ LGE+++ L+ + E +G + LR + +++ G+ A
Sbjct: 1775 QALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQ 1834
Query: 91 AAHEREDLVQQ----LERAKEQIES-----------LEHDLQASVDELQDVKEERSSYQD 135
+ L+Q+ L+RA Q+E+ LE D A L V+ E+ +
Sbjct: 1835 KLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHE 1894
Query: 136 KVERLNQE---LNHILSGHENRI---------IDVDALCMENRY--------LQERLKQL 175
RL+ E L+ L+G E + ++ + +E + Q++ +L
Sbjct: 1895 DTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL 1954
Query: 176 HEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATP 235
+EV L+S A+ + LE R+ + Q L + Q+L S P+ P
Sbjct: 1955 QQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPFSPPSGP 2014
Score = 36.2 bits (82), Expect = 0.031
Identities = 62/290 (21%), Positives = 118/290 (40%), Gaps = 49/290 (16%)
Query: 1 MANQLRERHQSLKKKYREL---IDGDPSLPPEK----RKQANLAQLLRDSQDRNKHLGEE 53
++ QL R Q L++ RE ++ EK ++ A LA L ++ + L EE
Sbjct: 839 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898
Query: 54 --------------IKELQQRLGEVQGDNKLLR-----MTIAKQRLGDEAIGVRHFAAHE 94
+ E+Q++L +++ + L + +AK+ L E G+R
Sbjct: 899 ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIAT 958
Query: 95 REDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENR 154
+E E +++ E + QAS ++E+R+++++ ++RL +E E
Sbjct: 959 QEKASLDKELMAQKLVQAEREAQAS------LREQRAAHEEDLQRLQRE-------KEAA 1005
Query: 155 IIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVL 214
+++A E LQ +L++ EE L + + K L + Q + +L
Sbjct: 1006 WRELEA---ERAQLQSQLQREQEE---LLARLEAEKEELSEEIAALQQERDEGL----LL 1055
Query: 215 SAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQ 264
+ + Q LS + + + SLAT LE +K Q Q
Sbjct: 1056 AESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQ 1105
Score = 35.4 bits (80), Expect = 0.052
Identities = 23/107 (21%), Positives = 47/107 (43%), Gaps = 3/107 (2%)
Query: 89 HFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHIL 148
H A H+R+ VQ + E + L L+ +L D + ER + +++++RL + + +
Sbjct: 525 HSALHKRQLQVQDMRGRYEASQDLLGTLRK---QLSDSESERRALEEQLQRLRDKTDGAM 581
Query: 149 SGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALER 195
HE+ +V L N L L + + + + + E+
Sbjct: 582 QAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREK 628
Score = 35.4 bits (80), Expect = 0.052
Identities = 55/245 (22%), Positives = 108/245 (44%), Gaps = 28/245 (11%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEV 64
LRE + L+ + R L D L +R+ + LR+SQ+ + +E EL++ LGE
Sbjct: 1153 LREAEE-LRTQLRLLEDARDGL---RRELLEAQRKLRESQEGREVQRQEAGELRRSLGEG 1208
Query: 65 QGDNKLLR-----MTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQAS 119
+ + LR + A ++ E I ++ A ++E + LE A+ + +L+
Sbjct: 1209 AKEREALRRSNEELRSAVKKAESERISLK-LANEDKEQKLALLEEARTAVGKEAGELRTG 1267
Query: 120 VDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRY-LQERL-KQLHE 177
LQ+V+ R + +++ L +++ + S EN + + ++ R L ER K+
Sbjct: 1268 ---LQEVERSRLEARRELQELRRQMKMLDS--ENTRLGRELAELQGRLALGERAEKESRR 1322
Query: 178 EVNLLKSNIAKYKNALE-----------RRKNSKGQGKSSSSALTGVLSAKQVQDLLSED 226
E L+ + K + +LE + + +G+ ++ L G L + + D
Sbjct: 1323 ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLD 1382
Query: 227 HGCSL 231
H L
Sbjct: 1383 HARGL 1387
Score = 31.6 bits (70), Expect = 0.76
Identities = 28/133 (21%), Positives = 64/133 (48%), Gaps = 10/133 (7%)
Query: 40 LRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQR-----LGDEAIGVRHFAAH- 93
L ++D+N HL + + + +Q R +++ R LG++ +R A
Sbjct: 1742 LNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL 1801
Query: 94 --EREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGH 151
+R + QL++ +E + + A+++ +Q +++ER Q+++ L + L + +
Sbjct: 1802 ELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEA-- 1859
Query: 152 ENRIIDVDALCME 164
E R ++ AL +E
Sbjct: 1860 EKREVERSALRLE 1872
Score = 31.2 bits (69), Expect = 0.99
Identities = 43/225 (19%), Positives = 96/225 (42%), Gaps = 16/225 (7%)
Query: 33 QANLA---QLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAI-GVR 88
QA LA + +R S+ + +++ L++ L + + + + I+K + + + G +
Sbjct: 1578 QAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDK 1637
Query: 89 HFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHIL 148
+ + + + Q SLE +LQ S L D + + + QD+V+ L +++
Sbjct: 1638 RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV---- 1693
Query: 149 SGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSS 208
+ + L + L L ++ E L+ + AL + S + +
Sbjct: 1694 ---ADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNL 1750
Query: 209 ALTGVLSA-KQVQDLLSEDHGCSLPATPQSISDLKSLATALLETI 252
L L+A + + +L E L A Q++S+ + +++L E +
Sbjct: 1751 HLQKALTACEHDRQVLQE----RLDAARQALSEARKQSSSLGEQV 1791
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 50.1 bits (118), Expect = 2e-06
Identities = 69/298 (23%), Positives = 133/298 (44%), Gaps = 40/298 (13%)
Query: 1 MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR 60
+ Q++E+ L + +L+ SL EK +QA + Q+ +S+ + L ++KEL +
Sbjct: 2215 LTKQIQEKQGQLSE-LDKLLSSFKSLLEEK-EQAEI-QIKEESKTAVEMLQNQLKELNEA 2271
Query: 61 LGEVQGDNKLLRMTIAKQRLGDEAIGVRH------------FAAHEREDL--VQQLERA- 105
+ + GD ++++ T +Q L D I H A E++ L +QQL+ +
Sbjct: 2272 VAALCGDQEIMKAT--EQSL-DPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESE 2328
Query: 106 ------KEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVD 159
K ++E+LE +L+ + + E + + +VE L ++ + +DV
Sbjct: 2329 HHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVV 2388
Query: 160 ALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSA--- 216
+ E L L++ E ++ L+ + ++N L+ ++ K Q K SS +L
Sbjct: 2389 TIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLK 2448
Query: 217 ---KQVQDLLSEDHGCSLPATPQSISD----LKSLATALLETIHE-KNMVIQHQRQTN 266
++V L ++ C A Q++S L+ LL+ + E KN I Q N
Sbjct: 2449 ELNERVAALHNDQEACK--AKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN 2504
Score = 42.4 bits (98), Expect = 4e-04
Identities = 52/247 (21%), Positives = 107/247 (43%), Gaps = 13/247 (5%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEV 64
L+E+ QSL+K + L L + +AQL ++ + L +E + LQ RL E
Sbjct: 2033 LQEKLQSLEKDSQALSLTKCEL------ENQIAQLNKEKE----LLVKESESLQARLSES 2082
Query: 65 QGDNKLLRMTIAKQRLGDEAIGVRHFAAHER-EDLVQQLERAKEQIESLEHDLQASVDEL 123
+ + + + +R + E L + +E+ + +IE+ E ++L
Sbjct: 2083 DYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKL 2142
Query: 124 QDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLK 183
++ + E S +DKVE L +EL E I+D + E L+ +++++ + + +
Sbjct: 2143 KERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFE 2202
Query: 184 SNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKS 243
++ ++ E + + S L +LS+ + LL E + +S + ++
Sbjct: 2203 LDLVTLRSEKENLTKQIQEKQGQLSELDKLLSS--FKSLLEEKEQAEIQIKEESKTAVEM 2260
Query: 244 LATALLE 250
L L E
Sbjct: 2261 LQNQLKE 2267
Score = 40.8 bits (94), Expect = 0.001
Identities = 47/228 (20%), Positives = 105/228 (46%), Gaps = 18/228 (7%)
Query: 3 NQLRERHQSLKKKYREL----IDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQ 58
+Q+ HQ K++ EL ++ + + + K A+L L Q K+L E++
Sbjct: 2542 SQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE--L 2599
Query: 59 QRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQA 118
++ ++ K+ +MT + L E + A +E+L + R +++ L ++++
Sbjct: 2600 TKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKS 2659
Query: 119 SVDELQDVKEERSS--------YQDKVE---RLNQEL-NHILSGHENRIIDVDALCMENR 166
S D+L+++ E S ++D+VE ++ +E+ + L HE L N+
Sbjct: 2660 SKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNK 2719
Query: 167 YLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVL 214
+ ++ E++ + ++ K ++ K+SK + +S A T +L
Sbjct: 2720 QYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQIL 2767
Score = 38.1 bits (87), Expect = 0.008
Identities = 37/169 (21%), Positives = 77/169 (45%), Gaps = 20/169 (11%)
Query: 35 NLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHE 94
+L+Q + +Q++N L + E + + + L+ AK+ E + FA
Sbjct: 1038 DLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEH--QEFLTKLAFAEER 1095
Query: 95 REDLVQQLERAKEQIESLEHDLQA-SVDELQDVKEERSSYQDKVERLNQELNHILSGHEN 153
++L+ +LE ++ + S D Q S E +K+E + +++ ++ +E+N +L
Sbjct: 1096 NQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQ---- 1151
Query: 154 RIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQ 202
EN L + +K HE NL I +N+++ R++ + Q
Sbjct: 1152 ----------ENEQLMKVMKTKHECQNLESEPI---RNSVKERESERNQ 1187
Score = 35.4 bits (80), Expect = 0.052
Identities = 53/237 (22%), Positives = 103/237 (43%), Gaps = 36/237 (15%)
Query: 26 LPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRL------------------GEVQG- 66
L +++KQ + Q L++S+ L ++ L++ L GEV+
Sbjct: 2310 LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETL 2369
Query: 67 DNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDV 126
K+ MT + + L + + +R E+E+L +L++ +E+I LE + + LQ+
Sbjct: 2370 KAKIEGMTQSLRGLELDVVTIRS----EKENLTNELQKEQERISELEIINSSFENILQEK 2425
Query: 127 KEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNI 186
++E+ ++K + L L R V AL + + + + L +V L+
Sbjct: 2426 EQEKVQMKEKSSTAMEMLQTQLKELNER---VAALHNDQEACKAKEQNLSSQVECLELEK 2482
Query: 187 AKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKS 243
A+ L+ KN+ +SS + L +Q++ ED L + IS LK+
Sbjct: 2483 AQLLQGLDEAKNNYIVLQSSVNGL--------IQEV--EDGKQKLEKKDEEISRLKN 2529
Score = 35.0 bits (79), Expect = 0.068
Identities = 35/167 (20%), Positives = 73/167 (43%), Gaps = 17/167 (10%)
Query: 36 LAQLLRDSQDRNKHLGEEIK-------ELQQRLGEVQGDNKLLRMTIAK---QRLGDEAI 85
L +++ + + N L E+++ EL QR+ +G N L M K + +GD
Sbjct: 1828 LEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVA 1887
Query: 86 GVRHFAAHEREDLVQQLERAKEQIESLEH-------DLQASVDELQDVKEERSSYQDKVE 138
V D+ +L R + + S+EH DL+ E ++++ + Q +
Sbjct: 1888 KVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIV 1947
Query: 139 RLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSN 185
L +EL+ + S ++D + + L + +++ E+ L+S+
Sbjct: 1948 CLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESH 1994
Score = 34.3 bits (77), Expect = 0.12
Identities = 37/186 (19%), Positives = 80/186 (43%), Gaps = 19/186 (10%)
Query: 30 KRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLR------------MTIAK 77
+ K+ Q+ S + L ++KEL +R+ + D + + + + K
Sbjct: 2423 QEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2482
Query: 78 QRLG---DEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQ 134
+L DEA L+Q++E K+++E + ++ +++QD +E+ S
Sbjct: 2483 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQD-QEQLVSKL 2541
Query: 135 DKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALE 194
+VE +Q N ++++ + + LQ + L + + +L+S+ +N LE
Sbjct: 2542 SQVEGEHQLWKEQNLELRNLTVELE---QKIQVLQSKNASLQDTLEVLQSSYKNLENELE 2598
Query: 195 RRKNSK 200
K K
Sbjct: 2599 LTKMDK 2604
Score = 33.5 bits (75), Expect = 0.20
Identities = 43/216 (19%), Positives = 82/216 (37%), Gaps = 53/216 (24%)
Query: 39 LLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDL 98
LL + +N+ L +I EL+ RL QG K ++ + K ++L
Sbjct: 279 LLDQLKAQNQELRNKINELELRL---QGHEKEMKGQVNKF-----------------QEL 318
Query: 99 VQQLERAKEQIESLEHDLQASVDEL--------------------------------QDV 126
QLE+AK ++ E L DEL Q+
Sbjct: 319 QLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNA 378
Query: 127 KEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENR-YLQERLKQLHEEVNLLKSN 185
+ R S + K++ +E LS + +D C++ + L + L+Q N+L++
Sbjct: 379 ESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAE 438
Query: 186 IAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQD 221
+ K + ++ +N+ + K A Q+++
Sbjct: 439 LDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE 474
Score = 32.7 bits (73), Expect = 0.34
Identities = 37/129 (28%), Positives = 60/129 (46%), Gaps = 19/129 (14%)
Query: 29 EKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVR 88
E+ K+ + L+ Q+ L + KE QQR + Q D+ + KQ++ +E
Sbjct: 6 EEWKEGLPTRALQKIQELEGQLDKLKKEKQQR--QFQLDSLEAALQKQKQKVENEKT--- 60
Query: 89 HFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQD--------KVERL 140
E +L ++ +R E ESLE Q ELQ VKE + ++Q+ ++E+L
Sbjct: 61 -----EGTNLKRENQRLMEICESLEKTKQKISHELQ-VKESQVNFQEGQLNSGKKQIEKL 114
Query: 141 NQELNHILS 149
QEL S
Sbjct: 115 EQELKRCKS 123
Score = 32.7 bits (73), Expect = 0.34
Identities = 31/140 (22%), Positives = 66/140 (47%), Gaps = 16/140 (11%)
Query: 96 EDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQ-----------EL 144
++ V LE + E + + DLQ +EL +K E K E+++Q +L
Sbjct: 829 QNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKL 888
Query: 145 NHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGK 204
S H+N ++ +EN+ ++ L+ L+++V ++ I + K + ++S + +
Sbjct: 889 QEDTSAHQN-VVAETLSALENK--EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQ 945
Query: 205 SSSSALTGVLSAKQVQDLLS 224
S L+ L K++ ++S
Sbjct: 946 LLSETLS--LEKKEMSSIIS 963
Score = 31.6 bits (70), Expect = 0.76
Identities = 38/177 (21%), Positives = 76/177 (42%), Gaps = 12/177 (6%)
Query: 29 EKRKQANLAQLLRDSQDRNK-HLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGV 87
E +K+ NL + + + R HL E+K ++Q L + Q + ++ AK + +
Sbjct: 483 EMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMK---AKNTSQETMLRD 539
Query: 88 RHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHI 147
+++E+ + LE+ K + LE S D L+ + DK+ + +E +
Sbjct: 540 LQEKINQQENSLT-LEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL 598
Query: 148 LSGHENRIIDVDALCMENRYL-------QERLKQLHEEVNLLKSNIAKYKNALERRK 197
LS E + + + L E ++ L Q+ E L+S I + L+ ++
Sbjct: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQ 655
Score = 30.8 bits (68), Expect = 1.3
Identities = 24/129 (18%), Positives = 53/129 (41%)
Query: 94 EREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHEN 153
ER L +L+ ++ +L+ + ++ Q+++ +S ++ E+ +
Sbjct: 1959 ERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQT 2018
Query: 154 RIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGV 213
DV L + +LQE+L+ L ++ L + +N + + K S +L
Sbjct: 2019 LSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQAR 2078
Query: 214 LSAKQVQDL 222
LS + L
Sbjct: 2079 LSESDYEKL 2087
Score = 28.9 bits (63), Expect = 4.9
Identities = 28/135 (20%), Positives = 57/135 (42%), Gaps = 8/135 (5%)
Query: 1 MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR 60
+ Q+ ++L+ K L + L ++ K + +R + ++L EI+ L
Sbjct: 629 LLTQMESEKENLQSKINHL---ETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNV 685
Query: 61 LGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASV 120
L + + ++ + + E +H E E++ + + Q+E LEH LQ
Sbjct: 686 LDSKSVEVETQKLAYMELQQKAEFSDQKH--QKEIENMCLKTSQLTGQVEDLEHKLQLLS 743
Query: 121 DELQDVKEERSSYQD 135
+E+ D + YQD
Sbjct: 744 NEIMD---KDRCYQD 755
Score = 28.1 bits (61), Expect = 8.4
Identities = 35/180 (19%), Positives = 75/180 (41%), Gaps = 10/180 (5%)
Query: 7 ERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQG 66
ER+Q K +L + SL + L +LR+ + + + +E + LQ L ++G
Sbjct: 1184 ERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRG 1243
Query: 67 DNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLV---QQLERAKEQIESLEHDLQASVDEL 123
D L + + E G++ E + +L ++ L+ LQ ++++L
Sbjct: 1244 D---LETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKL 1300
Query: 124 QDVKE----ERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEV 179
++++ ++ + V LN + ++ +V L E + L + LH E+
Sbjct: 1301 NELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGEL 1360
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 49.7 bits (117), Expect = 3e-06
Identities = 58/239 (24%), Positives = 103/239 (43%), Gaps = 30/239 (12%)
Query: 12 LKKKYRELI-DGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEV--QGDN 68
LK K+ +I D + L E++++ L + R + + L ++I ELQ ++ E+ Q
Sbjct: 1021 LKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAK 1080
Query: 69 KLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIES--------------LEH 114
K + A R+ +EA ++ A + +L Q+ +E +ES L
Sbjct: 1081 KEEELQAALARVEEEA-AQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGE 1139
Query: 115 DLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQ----E 170
+L+A EL+D + ++ Q+ + QE+N + E +A E R E
Sbjct: 1140 ELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199
Query: 171 RLKQLHEEVNLLKSNIAKYKNALERRKNSKG-------QGKSSSSALTGVLSAKQVQDL 222
L + E+ +K+N+ K K LE + QGK S + A Q+Q+L
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEA-QLQEL 1257
Score = 49.3 bits (116), Expect = 4e-06
Identities = 42/171 (24%), Positives = 82/171 (47%), Gaps = 20/171 (11%)
Query: 39 LLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFA------A 92
LL+ S+ + + +E + ++ R ++ +N+L M + +L E + ++
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 93 HEREDLVQQLERAKEQIESLEHDLQASVDE----LQDVKEERSSYQDKVERLNQELNHIL 148
E E+L +L K+++E + HDL+A V+E Q ++ E+ Q ++ L ++L
Sbjct: 897 AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEE 956
Query: 149 SGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKS---NIAKYKNALERR 196
S + L +E + +LK+L EE +L+ +AK K LE R
Sbjct: 957 SARQK-------LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000
Score = 48.5 bits (114), Expect = 6e-06
Identities = 54/259 (20%), Positives = 108/259 (41%), Gaps = 25/259 (9%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRD---------------SQDRNK 48
Q +E + LK E+I L +R + AQ RD + + +
Sbjct: 1667 QAKENEKKLKSMEAEMIQLQEELAAAERAKRQ-AQQERDELADEIANSSGKGALALEEKR 1725
Query: 49 HLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQ 108
L I +L++ L E QG+ +L+ + K L + I + Q+ E A++Q
Sbjct: 1726 RLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTD---LNLERSHAQKNENARQQ 1782
Query: 109 IESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYL 168
+E +L+ + E++ +S Y+ + L ++ + +N + A C + R
Sbjct: 1783 LERQNKELKVKLQEMEGTV--KSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRT 1840
Query: 169 QERLKQLHEEVNLLKSNIAKYKN----ALERRKNSKGQGKSSSSALTGVLSAKQVQDLLS 224
+++LK + +V+ + N +YK+ A R K K Q + + ++++
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 225 EDHGCSLPATPQSISDLKS 243
ED + A + +S LK+
Sbjct: 1901 EDATETADAMNREVSSLKN 1919
Score = 41.2 bits (95), Expect = 0.001
Identities = 46/207 (22%), Positives = 87/207 (42%), Gaps = 28/207 (13%)
Query: 18 ELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAK 77
+L D L E R++ +L+ L+ +D E+++E ++ ++ L +A
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 78 QRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKV 137
+ + ED V LE A+E L+ DL+ L EE+ + DK+
Sbjct: 1369 MK-------------KKMEDSVGCLETAEEVKRKLQKDLEG----LSQRHEEKVAAYDKL 1411
Query: 138 E----RLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNAL 193
E RL QEL+ +L +D+D L+++ K+ + + K+ AKY
Sbjct: 1412 EKTKTRLQQELDDLL-------VDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER 1464
Query: 194 ERRKNSKGQGKSSSSALTGVLSAKQVQ 220
+R + + ++ + +L L Q
Sbjct: 1465 DRAEAEAREKETKALSLARALEEAMEQ 1491
Score = 40.0 bits (92), Expect = 0.002
Identities = 53/287 (18%), Positives = 118/287 (41%), Gaps = 38/287 (13%)
Query: 13 KKKYRELIDGDPSLPPEKRKQANLAQL-LRDSQDRNKHLGEEIKELQQRLGEVQGDNKLL 71
+KK+ +L+ + ++ + ++ + A+ R+ + + L ++E ++ E++ NK
Sbjct: 1443 QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQF 1502
Query: 72 RMTIAKQRLGDEAIGVR-HFAAHEREDLVQQLERAKEQIESLEHDLQASVD--------- 121
R + + +G H + L QQ+E K Q+E LE +LQA+ D
Sbjct: 1503 RTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNL 1562
Query: 122 ---------ELQDVKEERSSYQDKVERLNQELNHILSGHE---------NRIIDVDALCM 163
+LQ E+ + ++ R +E+ L + +++D +
Sbjct: 1563 QAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDL 1622
Query: 164 E------NRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAK 217
E N+ E +KQL + +K + + + R+ Q K + L + A+
Sbjct: 1623 EAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS-MEAE 1681
Query: 218 QVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQ 264
+Q L E+ + A Q+ + LA + + + + ++ +R+
Sbjct: 1682 MIQ--LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR 1726
Score = 37.4 bits (85), Expect = 0.014
Identities = 32/154 (20%), Positives = 63/154 (40%), Gaps = 3/154 (1%)
Query: 103 ERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALC 162
E ++E+L+ L A +LQ+ + + + E L L E D++A
Sbjct: 865 ENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARV 924
Query: 163 MENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDL 222
E +ER + L E ++ NI + + LE ++++ + + L + + +
Sbjct: 925 EEE---EERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQI 981
Query: 223 LSEDHGCSLPATPQSISDLKSLATALLETIHEKN 256
+ ED C L + + D + T L EK+
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKS 1015
Score = 33.5 bits (75), Expect = 0.20
Identities = 43/232 (18%), Positives = 102/232 (43%), Gaps = 26/232 (11%)
Query: 2 ANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRL 61
A +LR R + K++ E+ +L + + ++R +HL E K++QQ +
Sbjct: 899 AEELRARLTAKKQELEEICH-------------DLEARVEEEEERCQHLQAEKKKMQQNI 945
Query: 62 GEVQGDNKLLRMTIAKQRLGDEAIGVR-HFAAHEREDLVQQ-----LERAKEQIESLEHD 115
E+ + +L A+Q+L E + E E ++ + L + K+ +E +
Sbjct: 946 QEL--EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAE 1003
Query: 116 LQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQL 175
++ E ++ + + ++K E + +L L E + +++ R L+ L
Sbjct: 1004 FTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELE---KTRRKLEGDSTDL 1060
Query: 176 HEEVNLLKSNIAKYKNALERRKN--SKGQGKSSSSALTGVLSAKQVQDLLSE 225
+++ L++ IA+ K L +++ + A ++ K++++L S+
Sbjct: 1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQ 1112
Score = 32.0 bits (71), Expect = 0.58
Identities = 51/234 (21%), Positives = 94/234 (40%), Gaps = 34/234 (14%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEK-RKQANLAQLLRDSQDRNKHLGEEIKELQQRLG 62
+L++ + L +++ E + L K R Q L LL D D + +++ Q++
Sbjct: 1389 KLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL-DHQRQSACNLEKKQKKFD 1447
Query: 63 EVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHERE----DLVQQLERAKEQIESLEH---- 114
++ + K + A++R EA A E+E L + LE A EQ LE
Sbjct: 1448 QLLAEEKTISAKYAEERDRAEA------EAREKETKALSLARALEEAMEQKAELERLNKQ 1501
Query: 115 -------------DLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENR--IIDVD 159
D+ SV EL+ K ++++ +EL L E+ ++V+
Sbjct: 1502 FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVN 1561
Query: 160 ALCME---NRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSAL 210
M+ R LQ R +Q E+ L + + + LE + + ++ L
Sbjct: 1562 LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL 1615
Score = 31.2 bits (69), Expect = 0.99
Identities = 33/147 (22%), Positives = 63/147 (42%), Gaps = 13/147 (8%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGE 63
QL +++ LK K +E+ +G + + +A++ L + L E KE Q +
Sbjct: 1782 QLERQNKELKVKLQEM-EGTV----KSKYKASITALEAKIAQLEEQLDNETKERQAACKQ 1836
Query: 64 VQGDNKLLRMTIAKQRLGDEAIGVRHF------AAHEREDLVQQLERAKEQIESLEHDLQ 117
V+ K L+ + + + DE + A+ + L +QLE A+E+ + +
Sbjct: 1837 VRRTEKKLKDVLLQ--VDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRR 1894
Query: 118 ASVDELQDVKEERSSYQDKVERLNQEL 144
EL+D E + +V L +L
Sbjct: 1895 KLQRELEDATETADAMNREVSSLKNKL 1921
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 49.7 bits (117), Expect = 3e-06
Identities = 61/259 (23%), Positives = 114/259 (44%), Gaps = 20/259 (7%)
Query: 6 RERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQ 65
RER Q+L+++ G+ + K Q NLA L + +R EE++ L+ G++Q
Sbjct: 1399 RERAQALQEQ------GELKVAQGKALQENLALLTQTLAERE----EEVETLR---GQIQ 1445
Query: 66 GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQD 125
K M A L + R+ +++ +Q+LE+ + +E L +Q +L
Sbjct: 1446 ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTV 1505
Query: 126 VKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSN 185
+E+ + E L H L E + +++ + + L+++L L L+ N
Sbjct: 1506 QREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEEN 1565
Query: 186 IAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLA 245
K + + K +GQ ++ ALT + L E+ L A I DL+S +
Sbjct: 1566 HHKMECQQKLIKELEGQRETQRVALTHL-------TLDLEERSQELQAQSSQIHDLESHS 1618
Query: 246 TALLETIHEKNMVIQHQRQ 264
T L + E++ ++ QR+
Sbjct: 1619 TVLARELQERDQEVKSQRE 1637
Score = 47.0 bits (110), Expect = 2e-05
Identities = 49/171 (28%), Positives = 72/171 (42%), Gaps = 7/171 (4%)
Query: 44 QDRNKHLGEEIKELQQRLGEVQGDNKLLR-MTIAKQRLGDEAIGVRHFAAHEREDLVQQL 102
Q ++ EE K L+QRL ++ G+ L T+ Q D R RE+L QQL
Sbjct: 420 QQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQL 479
Query: 103 ERAKEQIESLEH---DLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVD 159
E +++ L +LQ D Q KEE+ R + L +L G E +
Sbjct: 480 EVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAK---QS 536
Query: 160 ALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSAL 210
E L+E L+ H E LL+ + AL R + S + SS + L
Sbjct: 537 ESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
Score = 44.3 bits (103), Expect = 1e-04
Identities = 57/263 (21%), Positives = 105/263 (39%), Gaps = 39/263 (14%)
Query: 9 HQSLK-KKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRL-GEVQG 66
HQ L+ +K ++I+ + +KQ + L + N H E QQ+L E++G
Sbjct: 1526 HQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK----MECQQKLIKELEG 1581
Query: 67 DNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDV 126
+ R+ + L + E+ Q+L+ QI LE ELQ+
Sbjct: 1582 QRETQRVALTHLTL-------------DLEERSQELQAQSSQIHDLESHSTVLARELQER 1628
Query: 127 KEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNI 186
+E S ++++E L ++ H+ E R L ++ +Q Q + +L+ ++
Sbjct: 1629 DQEVKSQREQIEELQRQKEHLTQDLERR---DQELMLQKERIQVLEDQRTRQTKILEEDL 1685
Query: 187 AKYKNALERR-----------KNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATP 235
+ K +L R + +GK S A G L + L+ D +
Sbjct: 1686 EQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSL---EHMKLILRDKEKEVECQQ 1742
Query: 236 QSISDLKSLATAL---LETIHEK 255
+ I +L+ L L L+ +H K
Sbjct: 1743 EHIHELQELKDQLEQQLQGLHRK 1765
Score = 43.1 bits (100), Expect = 3e-04
Identities = 63/245 (25%), Positives = 105/245 (42%), Gaps = 28/245 (11%)
Query: 5 LRERHQSLKKKYRELID--GDPSLPPEKRKQANLAQL---LRDSQDRNKHLGEEIKELQQ 59
LRER + L + R+L+ + P K ++ +L + LRD + + E I ELQ+
Sbjct: 1692 LRERGRELTTQ-RQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE 1750
Query: 60 RLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLV--QQLERAKEQIESLEHDLQ 117
+++ + L + + L + E+E +V QQL+ A+EQ E E LQ
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSL--------LLSQREQEIVVLQQQLQEAREQGELKEQSLQ 1802
Query: 118 ASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIID-VDALCMENRYLQERLKQLH 176
+ +DE Q +R ++E L QE G E R+ + DAL LK+ H
Sbjct: 1803 SQLDEAQRALAQR---DQELEALQQEQQQ-AQGQEERVKEKADALQGALEQAHMTLKERH 1858
Query: 177 EEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVL---SAKQVQDLLSEDHGCSLPA 233
E+ K + LE +G+ + + G L S +Q + LL+ C+ A
Sbjct: 1859 GELQDHKEQARR----LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQA 1914
Query: 234 TPQSI 238
+
Sbjct: 1915 QEHEV 1919
Score = 40.8 bits (94), Expect = 0.001
Identities = 50/271 (18%), Positives = 110/271 (40%), Gaps = 14/271 (5%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEV 64
L+ERH L+ + + L E R+ L ++L D + ++ + + LQQ+ E
Sbjct: 1854 LKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQ 1913
Query: 65 QGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQ 124
++++ + L +A+ ER+ ++ L + E +A + LQ
Sbjct: 1914 AQEHEVETRALQDSWLQAQAV------LKERDQELEALRAESQSSRHQEEAARARAEALQ 1967
Query: 125 D-VKEERSSYQDKVERL--NQELNHILSGHENRI-IDVDALCMENRYLQERLK----QLH 176
+ + + ++ Q K + L EL+ L + +DA +R L+E L+ ++
Sbjct: 1968 EALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQ 2027
Query: 177 EEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQ 236
++ + ++ + + AL +R + L L+ + ++++ E +
Sbjct: 2028 DQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEE 2087
Query: 237 SISDLKSLATALLETIHEKNMVIQHQRQTNK 267
I L L T+ +K I R+T +
Sbjct: 2088 EIRGLHQSVRELQLTLAQKEQEILELRETQQ 2118
Score = 35.4 bits (80), Expect = 0.052
Identities = 41/208 (19%), Positives = 95/208 (45%), Gaps = 18/208 (8%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGE 63
+ +R ++L +K L + L + A L LRD Q EE +E+Q++L E
Sbjct: 649 EAEKRREALWEKNTHL---EAQLQKAEEAGAELQADLRDIQ-------EEKEEIQKKLSE 698
Query: 64 VQGDNKLLRMTIAKQRLGDEAIGVRHF---AAHEREDLVQQLERAKEQIESLEHDLQASV 120
+ + T ++L EA A E+E LV++ + +++++E D Q
Sbjct: 699 SRHQQEAA--TTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLA 756
Query: 121 DELQDVKEERSSYQDKVERLNQELNHILSGHENRI-IDVDALCMENRYLQERLKQLHEEV 179
++LQ + + + + Q+ N ++ + ++ + + + +Q ++ L E+
Sbjct: 757 EQLQGLSSAKELLESSLFEAQQQ-NSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL 815
Query: 180 NLLKSNIAKYKNALERR-KNSKGQGKSS 206
+ +S + ++A R+ ++ +GK++
Sbjct: 816 DTERSQAEQERDAAARQLAQAEQEGKTA 843
Score = 33.9 bits (76), Expect = 0.15
Identities = 43/193 (22%), Positives = 82/193 (42%), Gaps = 30/193 (15%)
Query: 10 QSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNK 69
++L + +EL D L E+ +Q Q L++ Q+ L +++E Q+ L E
Sbjct: 932 ETLLQTQKELADASQQL--ERLRQDMKVQKLKE-QETTGILQTQLQEAQRELKEA----- 983
Query: 70 LLRMTIAKQRLGDEAIGVRHFAA--HEREDLVQQLERAKEQIESLEHDLQASVDELQDVK 127
A+Q D A ++ ++ DL +Q+E K Q+ + + + E+Q+
Sbjct: 984 ------ARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKL 1037
Query: 128 EERSSY---QDKVERLNQELNHILSGHENRII-----------DVDALCMENRYLQERLK 173
E Y Q ++ER L L E R++ ++ AL + + Q K
Sbjct: 1038 RETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQK 1097
Query: 174 QLHEEVNLLKSNI 186
+L ++ LL+ +
Sbjct: 1098 ELSAQMELLRQEV 1110
Score = 28.5 bits (62), Expect = 6.4
Identities = 42/213 (19%), Positives = 89/213 (41%), Gaps = 27/213 (12%)
Query: 7 ERHQSLKKKYRELIDGDPSLPPEKRKQA-----NLAQLLRDSQDRNKHLGEEIKELQQRL 61
E+ + ++K EL+ SL +KR Q Q L + +HL ++E +Q+L
Sbjct: 1448 EKQREMQKAALELL----SLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKL 1503
Query: 62 G-------EVQGDNKLLRMTIAKQRLG----DEAIGVRHFAAHEREDLVQQLERAKEQIE 110
E++ D + R + Q L D+ I + + + + LE ++E
Sbjct: 1504 TVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELE 1563
Query: 111 SLEHDLQASVDELQDVKEERSSYQDKVERLN---QELNHILSGHENRIIDVDA----LCM 163
H ++ +++++ +R + + + L +E + L ++I D+++ L
Sbjct: 1564 ENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR 1623
Query: 164 ENRYLQERLKQLHEEVNLLKSNIAKYKNALERR 196
E + + +K E++ L+ LERR
Sbjct: 1624 ELQERDQEVKSQREQIEELQRQKEHLTQDLERR 1656
Score = 28.1 bits (61), Expect = 8.4
Identities = 45/226 (19%), Positives = 94/226 (41%), Gaps = 40/226 (17%)
Query: 1 MANQLRERHQSLKK--KYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQ 58
+A+ L + HQ L K + R+++ + + L + L D++ + E+++LQ
Sbjct: 1241 VASALHKLHQDLWKTQQTRDVL---------RDQVQKLEERLTDTEAEKSQVHTELQDLQ 1291
Query: 59 QRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDL----VQQLERA--KEQIESL 112
++L + Q + + + L E + + A + L +Q++E +E +++
Sbjct: 1292 RQLSQNQEEKS--KWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAA 1349
Query: 113 EHDLQASVDELQ------------------DVKEERSSYQDKVERLNQELNHILSGHEN- 153
+ +L A V+ LQ D++ RS+ + K E + E + E
Sbjct: 1350 KENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQG 1409
Query: 154 --RIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRK 197
++ AL L + L + EEV L+ I + + E +K
Sbjct: 1410 ELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQK 1455
>gi|10864047 epidermal growth factor receptor pathway substrate
15-like 1 [Homo sapiens]
Length = 864
Score = 49.7 bits (117), Expect = 3e-06
Identities = 45/190 (23%), Positives = 81/190 (42%), Gaps = 16/190 (8%)
Query: 17 RELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLG------------EV 64
+EL D + +R++ +L Q +R+ ++ + E++ELQ L +
Sbjct: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
Query: 65 QGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQ 124
++L M K +L D VR + +D Q + K QI+S E DL++ D+L
Sbjct: 444 DAQDRLDEMDQQKAKLRDMLSDVRQ----KCQDETQMISSLKTQIQSQESDLKSQEDDLN 499
Query: 125 DVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKS 184
K E + Q + +L Q + E I + + E + +L QLHE
Sbjct: 500 RAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHR 559
Query: 185 NIAKYKNALE 194
++ +Y L+
Sbjct: 560 SLEQYDQVLD 569
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 49.3 bits (116), Expect = 4e-06
Identities = 58/241 (24%), Positives = 109/241 (45%), Gaps = 44/241 (18%)
Query: 3 NQLRERHQSLKKKYRE--LIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQ- 59
+QL+ERHQ +K++ ++ + L ++++ + Q N+ + E++K QQ
Sbjct: 749 HQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQM-------QRYNQRMIEQLKVRQQQ 801
Query: 60 ---RLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQ--QLERAKEQIESLEH 114
RL ++Q RM + K+ L G AA +RE + Q Q E +++ E L+
Sbjct: 802 EKARLPKIQRSEGKTRMAMYKKSLHINGGGS---AAEQREKIKQFSQQEEKRQKSERLQQ 858
Query: 115 DLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQ 174
Q ++++D+ + S ++++L E H+L HE ++LK
Sbjct: 859 Q-QKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHET----------------QKLKA 901
Query: 175 LHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPAT 234
L E N N+ ++++ L RK K+ L +++ LSE+ C P+T
Sbjct: 902 LDESHN---QNLKEWRDKLRPRK------KALEEDLNQKKREQEMFFKLSEEAECPNPST 952
Query: 235 P 235
P
Sbjct: 953 P 953
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 49.3 bits (116), Expect = 4e-06
Identities = 54/218 (24%), Positives = 102/218 (46%), Gaps = 24/218 (11%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRK-QANLAQLLRDSQDR---NKHLGEEIKELQQ 59
+ +E++ SL++K EL L + + +A+ Q L+D Q + N L EL +
Sbjct: 713 EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK 772
Query: 60 RLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQ-----LERAKEQIESLEH 114
+L + R+ + K+ E+I + E + +++Q + K Q E L +
Sbjct: 773 QLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832
Query: 115 DLQASVDELQDVKEER-------SSYQDKVERLNQELNHILSGHENR-------IIDVDA 160
+Q +V ELQ VK E+ S+ +DK+ +++ L + S E I+D++
Sbjct: 833 RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
Query: 161 LCMENRY-LQERLKQLHEEVNLLKSNIAKYKNALERRK 197
C E ++ LQ +++ +E LK ++ K K A + K
Sbjct: 893 TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLK 930
Score = 38.9 bits (89), Expect = 0.005
Identities = 37/173 (21%), Positives = 75/173 (43%), Gaps = 4/173 (2%)
Query: 52 EEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKE-QIE 110
+E+++L+ + E+ N+ L + K+ + +H + +Q K+ +
Sbjct: 288 QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ 347
Query: 111 SLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQE 170
L+ L AS L + E S + ++L +EL+ + + +++ + L + ++
Sbjct: 348 QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQ 407
Query: 171 RLKQLHEEVNLLKSNIAKYKNAL-ERRKNSKGQGKSSSSALTGVLSAKQVQDL 222
QL E+N L S + + + L E K Q + SS L +QV DL
Sbjct: 408 HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMD--KEQQVADL 458
Score = 36.6 bits (83), Expect = 0.024
Identities = 50/231 (21%), Positives = 93/231 (40%), Gaps = 35/231 (15%)
Query: 36 LAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHER 95
L + L + + + +HL E K+LQQ+ E + L+ I + H +
Sbjct: 377 LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQ--------------LHSK 422
Query: 96 EDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRI 155
L++ + E L+ Q S ++L D +++ + Q K+ RL ++L ++
Sbjct: 423 --LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN----- 475
Query: 156 IDVDALCMENRYLQERLKQLHEEVNLLK----SNIAKYKNALERRKNSKGQGKSSSSALT 211
E ++ ++ KQ H+E L+ + + + +N LE+ G L
Sbjct: 476 ------STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLE 529
Query: 212 GVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQ 262
+L + L E L A Q+ TA+L + EKN +Q Q
Sbjct: 530 ALLQKSKENISLLEKEREDLYAKIQAGEG----ETAVLNQLQEKNHTLQEQ 576
Score = 36.2 bits (82), Expect = 0.031
Identities = 44/233 (18%), Positives = 93/233 (39%), Gaps = 38/233 (16%)
Query: 3 NQLRERHQSLKKKYRELIDG-DPSLPPEKRKQANLAQL-------LRDSQDRNKHLGEEI 54
NQL+E++ +L+++ +L + K+ Q NL LR +QDR L +
Sbjct: 564 NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623
Query: 55 KELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEH 114
EL +L E + K+ ++ I + + + +R DL L+ A+ ++ +
Sbjct: 624 NELNSQLNESK--EKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ 681
Query: 115 DLQASVDELQDV---------------------KEERSSYQDKVERLNQELN-------H 146
+L +L V KE+ S + K E L ++
Sbjct: 682 ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741
Query: 147 ILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNS 199
+ + E + D+ N L+ R +L +++ + K ++ + L+++ +
Sbjct: 742 VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA 794
Score = 32.0 bits (71), Expect = 0.58
Identities = 60/283 (21%), Positives = 109/283 (38%), Gaps = 35/283 (12%)
Query: 14 KKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRM 73
K ++L L EK K + L SQ+ K L + + L + D L+
Sbjct: 995 KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD---LKS 1051
Query: 74 TIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIES----LEHDLQASVDELQDVKEE 129
K L E + + L+Q+L+ AK +E E LQ LQD+++E
Sbjct: 1052 VEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE 1111
Query: 130 RS---------------------SYQDKVERLNQEL-NHILSGHE--NRIIDVDALCMEN 165
+S + ++ +LN+EL +H L + + D L ++
Sbjct: 1112 KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ 1171
Query: 166 RY-LQERLKQLHEEVNLLKSNIAKYKNALERRKNS-KGQGKSSSSALTGVLSAKQVQDLL 223
+ LQ + L V K N K+ +++ + K + + L + K+V
Sbjct: 1172 KLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKK 1231
Query: 224 SEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTN 266
E++ L T Q + ++L T E + V + ++QT+
Sbjct: 1232 HEENEAKL--TMQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272
Score = 30.4 bits (67), Expect = 1.7
Identities = 36/170 (21%), Positives = 77/170 (45%), Gaps = 9/170 (5%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGE 63
+L+ + SLK + L + +K+ +L ++ ++ L EIKE + + +
Sbjct: 1174 ELQGKADSLKAAVEQEKRNQQILKDQVKKEEE--ELKKEFIEKEAKLHSEIKEKEVGMKK 1231
Query: 64 VQGDNKLLRMTIAKQRLGDEAIGV--RHFAAHERE--DLVQQLERAKEQIESLEHDLQAS 119
+ + L M I +E +G + + + +R +L +Q + + +I LE +Q +
Sbjct: 1232 HEENEAKLTMQITAL---NENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNN 1288
Query: 120 VDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQ 169
DE + + E + ++E+L ++ + +N V L EN+ LQ
Sbjct: 1289 QDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
>gi|157042792 coiled-coil domain containing 64B [Homo sapiens]
Length = 508
Score = 49.3 bits (116), Expect = 4e-06
Identities = 51/230 (22%), Positives = 99/230 (43%), Gaps = 14/230 (6%)
Query: 1 MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR 60
+ L ER++ L+++ L L E+R Q +++ + + L E + R
Sbjct: 67 LGKMLLERNEELRRQLETL--SAQHLEREERLQ-------QENHELRRGLAARGAEWEAR 117
Query: 61 LGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAA-----HEREDLVQQLERAKEQIESLEHD 115
E++GD + LR + +QR + G A + L QQL +A + + L+ +
Sbjct: 118 AVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRE 177
Query: 116 LQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQL 175
L A + Q + + ++E L E + S ++ + L E + RL+
Sbjct: 178 LDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTT 237
Query: 176 HEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSE 225
HEE+ LL+ ++ LER ++ G+ S+ L +S + + L +
Sbjct: 238 HEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQD 287
Score = 35.8 bits (81), Expect = 0.040
Identities = 29/116 (25%), Positives = 55/116 (47%), Gaps = 5/116 (4%)
Query: 27 PPEKRKQANLAQLLRDSQDRNKHLGEEIK----ELQQRLGEVQGDNKLLRMTIAKQRLGD 82
PP+KR + A++L + + L +EI ELQ E+Q +L + L
Sbjct: 343 PPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEAL-H 401
Query: 83 EAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVE 138
A+ R A ++ +L QL R + +SL +L ++ + + +E ++QD ++
Sbjct: 402 SALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQ 457
>gi|109255236 centrosomal protein 63 isoform d [Homo sapiens]
Length = 475
Score = 48.9 bits (115), Expect = 5e-06
Identities = 46/213 (21%), Positives = 104/213 (48%), Gaps = 27/213 (12%)
Query: 53 EIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESL 112
EI+ L R+ ++ G + MT+ +++ E E E L++ L+ K ++++
Sbjct: 226 EIERLTMRVNDLVGTS----MTVLQEQQQKEE------KLRESEKLLEALQEEKRELKAA 275
Query: 113 EHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERL 172
LQ+ + + + + ++ Q+KV+ N + H I ++++ + L + L
Sbjct: 276 ---LQSQENLIHEARIQKEKLQEKVKATNTQ-------HAVEAISLESVSATCKQLSQEL 325
Query: 173 KQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSS-SSALTGVLSAKQVQDLLSEDH--GC 229
+ +EE+ ++++ +YK +++ K QG+ S SSAL G+ ++ L E H
Sbjct: 326 MEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGM--KMEISHLTQELHQRDI 383
Query: 230 SLPATPQSISDLKSLATALLETIHEKNMVIQHQ 262
++ +T S SD++ A ++ +K ++H+
Sbjct: 384 TIASTKGSSSDMEKRLRAEMQKAEDK--AVEHK 414
Score = 30.0 bits (66), Expect = 2.2
Identities = 25/128 (19%), Positives = 50/128 (39%), Gaps = 9/128 (7%)
Query: 48 KHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKE 107
K L +E+ E + L ++ N + I K ++ + LE K
Sbjct: 319 KQLSQELMEKYEELKRMEAHNNEYKAEIKK---------LKEQILQGEQSYSSALEGMKM 369
Query: 108 QIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRY 167
+I L +L + K S + ++ Q+ H+ + +++L +ENR+
Sbjct: 370 EISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRH 429
Query: 168 LQERLKQL 175
L E + +L
Sbjct: 430 LSEMVMKL 437
Score = 29.3 bits (64), Expect = 3.8
Identities = 43/181 (23%), Positives = 79/181 (43%), Gaps = 29/181 (16%)
Query: 94 EREDLVQQLE----RAKEQIESLEHDLQASV----DELQDVKEERSSYQDKVERLNQELN 145
E ++L++Q++ K + E H L+ + EL+ ++ + +V L+Q++
Sbjct: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
Query: 146 HILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKY--KNALERRKNSKG-- 201
HE + M Y QE LK+LHEE+ +LK + K K E R N+K
Sbjct: 84 E----HEKIKQE-----MTMEYKQE-LKKLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
Query: 202 QGKSSSSALTGVLSA-------KQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHE 254
+ +S LT + + Q L+ + SL A +++++ + A L +
Sbjct: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
Query: 255 K 255
K
Sbjct: 194 K 194
>gi|109255226 centrosomal protein 63 isoform c [Homo sapiens]
Length = 495
Score = 48.9 bits (115), Expect = 5e-06
Identities = 46/213 (21%), Positives = 104/213 (48%), Gaps = 27/213 (12%)
Query: 53 EIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESL 112
EI+ L R+ ++ G + MT+ +++ E E E L++ L+ K ++++
Sbjct: 226 EIERLTMRVNDLVGTS----MTVLQEQQQKEE------KLRESEKLLEALQEEKRELKAA 275
Query: 113 EHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERL 172
LQ+ + + + + ++ Q+KV+ N + H I ++++ + L + L
Sbjct: 276 ---LQSQENLIHEARIQKEKLQEKVKATNTQ-------HAVEAISLESVSATCKQLSQEL 325
Query: 173 KQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSS-SSALTGVLSAKQVQDLLSEDH--GC 229
+ +EE+ ++++ +YK +++ K QG+ S SSAL G+ ++ L E H
Sbjct: 326 MEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGM--KMEISHLTQELHQRDI 383
Query: 230 SLPATPQSISDLKSLATALLETIHEKNMVIQHQ 262
++ +T S SD++ A ++ +K ++H+
Sbjct: 384 TIASTKGSSSDMEKRLRAEMQKAEDK--AVEHK 414
Score = 30.0 bits (66), Expect = 2.2
Identities = 25/128 (19%), Positives = 50/128 (39%), Gaps = 9/128 (7%)
Query: 48 KHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKE 107
K L +E+ E + L ++ N + I K ++ + LE K
Sbjct: 319 KQLSQELMEKYEELKRMEAHNNEYKAEIKK---------LKEQILQGEQSYSSALEGMKM 369
Query: 108 QIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRY 167
+I L +L + K S + ++ Q+ H+ + +++L +ENR+
Sbjct: 370 EISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRH 429
Query: 168 LQERLKQL 175
L E + +L
Sbjct: 430 LSEMVMKL 437
Score = 29.3 bits (64), Expect = 3.8
Identities = 43/181 (23%), Positives = 79/181 (43%), Gaps = 29/181 (16%)
Query: 94 EREDLVQQLE----RAKEQIESLEHDLQASV----DELQDVKEERSSYQDKVERLNQELN 145
E ++L++Q++ K + E H L+ + EL+ ++ + +V L+Q++
Sbjct: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
Query: 146 HILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKY--KNALERRKNSKG-- 201
HE + M Y QE LK+LHEE+ +LK + K K E R N+K
Sbjct: 84 E----HEKIKQE-----MTMEYKQE-LKKLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
Query: 202 QGKSSSSALTGVLSA-------KQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHE 254
+ +S LT + + Q L+ + SL A +++++ + A L +
Sbjct: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
Query: 255 K 255
K
Sbjct: 194 K 194
>gi|62243374 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 48.9 bits (115), Expect = 5e-06
Identities = 60/288 (20%), Positives = 127/288 (44%), Gaps = 32/288 (11%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANL---AQLLRDSQDRNKHLGEEIKELQQR 60
QL+ER ++K +E ++ + ++ Q NL ++ LR+ +D GE I L+ R
Sbjct: 112 QLQEREAGAEEKMQEQLERN------RQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
Query: 61 LGEVQ-----GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKE-------Q 108
+ E+Q + ++ R+ KQ L E + ++H E +Q+L+ ++E Q
Sbjct: 166 ISELQWSVMDQEMRVKRLESEKQEL-QEQLDLQHKKCQEANQKIQELQASQEARADHEQQ 224
Query: 109 IESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHIL--SGHENRIIDVDALCME-- 164
I+ LE L + VK +S ++ RL +EL + S H + + + L E
Sbjct: 225 IKDLEQKLSLQEQDAAIVKNMKSELV-RLPRLERELKQLREESAHLREMRETNGLLQEEL 283
Query: 165 ---NRYL--QERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQV 219
R L QE++++ + L + + ER + G + L+ + Q
Sbjct: 284 EGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQ 343
Query: 220 QDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNK 267
++L +D ++ ++ + + + L + + + + +R+T++
Sbjct: 344 RELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHE 391
Score = 35.8 bits (81), Expect = 0.040
Identities = 63/284 (22%), Positives = 120/284 (42%), Gaps = 38/284 (13%)
Query: 2 ANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRL 61
A L + Q L+++ R++ L E++K+ L R Q R L +E ++ L
Sbjct: 359 ARGLEKARQQLQEELRQV---SGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAIL 415
Query: 62 GEVQGDNKLL------RMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERA---KEQIESL 112
G D++L ++T + D V +A L Q LE K++ + L
Sbjct: 416 GSY--DSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADML 473
Query: 113 EHDLQASVDELQDV-------KEERSSYQDKVERLNQELNHILSGHENRIID--VDALCM 163
E +L+ + +EE + + KVE L E + + E R+++ ++ +
Sbjct: 474 EMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRL--EEEKRMLEAQLERRAL 531
Query: 164 ENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLL 223
+ Y Q R K LH +N +++A+ +R + Q ++ L G+L A + +
Sbjct: 532 QGDYDQSRTKVLHMSLN--PTSVAR-----QRLREDHSQLQAECERLRGLLRAMERGGTV 584
Query: 224 SEDHGCSLPATPQS--ISDLKSLATALLETIHEKNMVIQHQRQT 265
D + + P S +++LK +E+ KN ++ QT
Sbjct: 585 PADLEAAAASLPSSKEVAELKK----QVESAELKNQRLKEVFQT 624
Score = 34.7 bits (78), Expect = 0.089
Identities = 44/197 (22%), Positives = 89/197 (45%), Gaps = 16/197 (8%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEV 64
L+E+ ++ K + + P L E ++ + LR+ ++ N L EE++ LQ++LG
Sbjct: 234 LQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGR- 292
Query: 65 QGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLE-RAKEQIESLEHDLQASVDEL 123
+ ++ T+ L +E + + + ER D L R E + +LQ L
Sbjct: 293 ---QEKMQETLVGLELENERL-LAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELAL 348
Query: 124 QDVKEERSSYQDKVERLNQELNHILSGHENRIIDV-------DALCMENRYLQERLKQLH 176
+D +S +E+ Q+L L ++++ +AL R LQ+R+ L
Sbjct: 349 KDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALA---RRLQKRVLLLT 405
Query: 177 EEVNLLKSNIAKYKNAL 193
+E + +++ + Y + L
Sbjct: 406 KERDGMRAILGSYDSEL 422
Score = 31.6 bits (70), Expect = 0.76
Identities = 38/171 (22%), Positives = 69/171 (40%), Gaps = 11/171 (6%)
Query: 101 QLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDA 160
QLE EQI S H +Q +++Q E S + +VE L + + +E +
Sbjct: 50 QLEERAEQIRSKSHLIQVEREKMQ---MELSHKRARVE-LERAASTSARNYEREVDRNQE 105
Query: 161 LCMENRYLQER-------LKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGV 213
L R LQER +++ E + N+ L +++S Q + +AL G
Sbjct: 106 LLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
Query: 214 LSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQ 264
+S Q + E L + Q + + L + ++K +Q ++
Sbjct: 166 ISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQE 216
>gi|62243369 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 48.9 bits (115), Expect = 5e-06
Identities = 60/288 (20%), Positives = 127/288 (44%), Gaps = 32/288 (11%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANL---AQLLRDSQDRNKHLGEEIKELQQR 60
QL+ER ++K +E ++ + ++ Q NL ++ LR+ +D GE I L+ R
Sbjct: 112 QLQEREAGAEEKMQEQLERN------RQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
Query: 61 LGEVQ-----GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKE-------Q 108
+ E+Q + ++ R+ KQ L E + ++H E +Q+L+ ++E Q
Sbjct: 166 ISELQWSVMDQEMRVKRLESEKQEL-QEQLDLQHKKCQEANQKIQELQASQEARADHEQQ 224
Query: 109 IESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHIL--SGHENRIIDVDALCME-- 164
I+ LE L + VK +S ++ RL +EL + S H + + + L E
Sbjct: 225 IKDLEQKLSLQEQDAAIVKNMKSELV-RLPRLERELKQLREESAHLREMRETNGLLQEEL 283
Query: 165 ---NRYL--QERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQV 219
R L QE++++ + L + + ER + G + L+ + Q
Sbjct: 284 EGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQ 343
Query: 220 QDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNK 267
++L +D ++ ++ + + + L + + + + +R+T++
Sbjct: 344 RELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHE 391
Score = 35.8 bits (81), Expect = 0.040
Identities = 63/284 (22%), Positives = 120/284 (42%), Gaps = 38/284 (13%)
Query: 2 ANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRL 61
A L + Q L+++ R++ L E++K+ L R Q R L +E ++ L
Sbjct: 359 ARGLEKARQQLQEELRQV---SGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAIL 415
Query: 62 GEVQGDNKLL------RMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERA---KEQIESL 112
G D++L ++T + D V +A L Q LE K++ + L
Sbjct: 416 GSY--DSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADML 473
Query: 113 EHDLQASVDELQDV-------KEERSSYQDKVERLNQELNHILSGHENRIID--VDALCM 163
E +L+ + +EE + + KVE L E + + E R+++ ++ +
Sbjct: 474 EMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRL--EEEKRMLEAQLERRAL 531
Query: 164 ENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLL 223
+ Y Q R K LH +N +++A+ +R + Q ++ L G+L A + +
Sbjct: 532 QGDYDQSRTKVLHMSLN--PTSVAR-----QRLREDHSQLQAECERLRGLLRAMERGGTV 584
Query: 224 SEDHGCSLPATPQS--ISDLKSLATALLETIHEKNMVIQHQRQT 265
D + + P S +++LK +E+ KN ++ QT
Sbjct: 585 PADLEAAAASLPSSKEVAELKK----QVESAELKNQRLKEVFQT 624
Score = 34.7 bits (78), Expect = 0.089
Identities = 44/197 (22%), Positives = 89/197 (45%), Gaps = 16/197 (8%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEV 64
L+E+ ++ K + + P L E ++ + LR+ ++ N L EE++ LQ++LG
Sbjct: 234 LQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGR- 292
Query: 65 QGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLE-RAKEQIESLEHDLQASVDEL 123
+ ++ T+ L +E + + + ER D L R E + +LQ L
Sbjct: 293 ---QEKMQETLVGLELENERL-LAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELAL 348
Query: 124 QDVKEERSSYQDKVERLNQELNHILSGHENRIIDV-------DALCMENRYLQERLKQLH 176
+D +S +E+ Q+L L ++++ +AL R LQ+R+ L
Sbjct: 349 KDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALA---RRLQKRVLLLT 405
Query: 177 EEVNLLKSNIAKYKNAL 193
+E + +++ + Y + L
Sbjct: 406 KERDGMRAILGSYDSEL 422
Score = 31.6 bits (70), Expect = 0.76
Identities = 38/171 (22%), Positives = 69/171 (40%), Gaps = 11/171 (6%)
Query: 101 QLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDA 160
QLE EQI S H +Q +++Q E S + +VE L + + +E +
Sbjct: 50 QLEERAEQIRSKSHLIQVEREKMQ---MELSHKRARVE-LERAASTSARNYEREVDRNQE 105
Query: 161 LCMENRYLQER-------LKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGV 213
L R LQER +++ E + N+ L +++S Q + +AL G
Sbjct: 106 LLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
Query: 214 LSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQ 264
+S Q + E L + Q + + L + ++K +Q ++
Sbjct: 166 ISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQE 216
>gi|62243332 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 48.9 bits (115), Expect = 5e-06
Identities = 60/288 (20%), Positives = 127/288 (44%), Gaps = 32/288 (11%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANL---AQLLRDSQDRNKHLGEEIKELQQR 60
QL+ER ++K +E ++ + ++ Q NL ++ LR+ +D GE I L+ R
Sbjct: 112 QLQEREAGAEEKMQEQLERN------RQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
Query: 61 LGEVQ-----GDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKE-------Q 108
+ E+Q + ++ R+ KQ L E + ++H E +Q+L+ ++E Q
Sbjct: 166 ISELQWSVMDQEMRVKRLESEKQEL-QEQLDLQHKKCQEANQKIQELQASQEARADHEQQ 224
Query: 109 IESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHIL--SGHENRIIDVDALCME-- 164
I+ LE L + VK +S ++ RL +EL + S H + + + L E
Sbjct: 225 IKDLEQKLSLQEQDAAIVKNMKSELV-RLPRLERELKQLREESAHLREMRETNGLLQEEL 283
Query: 165 ---NRYL--QERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQV 219
R L QE++++ + L + + ER + G + L+ + Q
Sbjct: 284 EGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQ 343
Query: 220 QDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNK 267
++L +D ++ ++ + + + L + + + + +R+T++
Sbjct: 344 RELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHE 391
Score = 35.8 bits (81), Expect = 0.040
Identities = 63/284 (22%), Positives = 120/284 (42%), Gaps = 38/284 (13%)
Query: 2 ANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRL 61
A L + Q L+++ R++ L E++K+ L R Q R L +E ++ L
Sbjct: 359 ARGLEKARQQLQEELRQV---SGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAIL 415
Query: 62 GEVQGDNKLL------RMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERA---KEQIESL 112
G D++L ++T + D V +A L Q LE K++ + L
Sbjct: 416 GSY--DSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADML 473
Query: 113 EHDLQASVDELQDV-------KEERSSYQDKVERLNQELNHILSGHENRIID--VDALCM 163
E +L+ + +EE + + KVE L E + + E R+++ ++ +
Sbjct: 474 EMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRL--EEEKRMLEAQLERRAL 531
Query: 164 ENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLL 223
+ Y Q R K LH +N +++A+ +R + Q ++ L G+L A + +
Sbjct: 532 QGDYDQSRTKVLHMSLN--PTSVAR-----QRLREDHSQLQAECERLRGLLRAMERGGTV 584
Query: 224 SEDHGCSLPATPQS--ISDLKSLATALLETIHEKNMVIQHQRQT 265
D + + P S +++LK +E+ KN ++ QT
Sbjct: 585 PADLEAAAASLPSSKEVAELKK----QVESAELKNQRLKEVFQT 624
Score = 34.7 bits (78), Expect = 0.089
Identities = 44/197 (22%), Positives = 89/197 (45%), Gaps = 16/197 (8%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEV 64
L+E+ ++ K + + P L E ++ + LR+ ++ N L EE++ LQ++LG
Sbjct: 234 LQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGR- 292
Query: 65 QGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLE-RAKEQIESLEHDLQASVDEL 123
+ ++ T+ L +E + + + ER D L R E + +LQ L
Sbjct: 293 ---QEKMQETLVGLELENERL-LAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELAL 348
Query: 124 QDVKEERSSYQDKVERLNQELNHILSGHENRIIDV-------DALCMENRYLQERLKQLH 176
+D +S +E+ Q+L L ++++ +AL R LQ+R+ L
Sbjct: 349 KDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALA---RRLQKRVLLLT 405
Query: 177 EEVNLLKSNIAKYKNAL 193
+E + +++ + Y + L
Sbjct: 406 KERDGMRAILGSYDSEL 422
Score = 31.6 bits (70), Expect = 0.76
Identities = 38/171 (22%), Positives = 69/171 (40%), Gaps = 11/171 (6%)
Query: 101 QLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDA 160
QLE EQI S H +Q +++Q E S + +VE L + + +E +
Sbjct: 50 QLEERAEQIRSKSHLIQVEREKMQ---MELSHKRARVE-LERAASTSARNYEREVDRNQE 105
Query: 161 LCMENRYLQER-------LKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGV 213
L R LQER +++ E + N+ L +++S Q + +AL G
Sbjct: 106 LLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
Query: 214 LSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQ 264
+S Q + E L + Q + + L + ++K +Q ++
Sbjct: 166 ISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQE 216
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 48.5 bits (114), Expect = 6e-06
Identities = 62/280 (22%), Positives = 137/280 (48%), Gaps = 39/280 (13%)
Query: 7 ERHQSLKKKYRELIDGDPSLPPEKRKQAN-----LAQLLRDSQDRNKHLGEEIKELQQRL 61
+R Q L+K+ +L + L + +QAN L +RD ++ + L +E E+Q++L
Sbjct: 2056 QREQELQKENLKLSSENIELKFQL-EQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKL 2114
Query: 62 GEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVD 121
G V+G + + TI + ++ IG+ + +V++++R EQ++ L + +
Sbjct: 2115 GHVRGSGRSGK-TIPEL---EKTIGLM-------KKVVEKVQRENEQLKKASGILTS--E 2161
Query: 122 ELQDVKEERSSYQDKVERLNQELNHILSGH-ENRIIDVDALCMENRYLQERLKQ---LHE 177
++ ++++E + ++E+L L H LS H E++ + + EN L++ LK+ E
Sbjct: 2162 KMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAE 2221
Query: 178 EVNLLKSNI--------AKYKNALERRKNSKGQGK----SSSSALTGVLSAKQVQDLLSE 225
++ + K+N+ + + +R + ++ +G + S + ++ + + L E
Sbjct: 2222 KLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKE 2281
Query: 226 DHGCSLPATPQSISDLKSL---ATALLETIHEKNMVIQHQ 262
+ QSI+DLK L AT + +++ N ++ Q
Sbjct: 2282 LE-TDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQ 2320
Score = 44.3 bits (103), Expect = 1e-04
Identities = 42/195 (21%), Positives = 92/195 (47%), Gaps = 24/195 (12%)
Query: 1 MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR 60
+ N++ + + L++K REL D + L EK+ LA ++++ N L E K L+++
Sbjct: 113 LRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKK 172
Query: 61 LGEVQGDNKLLRMTIAKQ------RLGDEA-----IGVRHFAAHEREDLVQQLERAKEQI 109
++ D + I Q R G+++ + +++ + D +Q L A E+I
Sbjct: 173 NEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKI 232
Query: 110 ESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQ 169
E +++ +++E E+ + ++++ + + +++ +D L EN + Q
Sbjct: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNV----------IDQLKKENDHYQ 282
Query: 170 ERLKQLHEEVNLLKS 184
Q+ E +LLKS
Sbjct: 283 ---LQVQELTDLLKS 294
Score = 37.7 bits (86), Expect = 0.011
Identities = 31/138 (22%), Positives = 63/138 (45%), Gaps = 15/138 (10%)
Query: 17 RELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQ-------GDNK 69
RELI+ + L + A L++ + NK L E +KE+ Q + E+Q G+
Sbjct: 614 RELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETS 673
Query: 70 LLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEE 129
L+ ++ +RL V + E + K Q++ L + EL++ ++E
Sbjct: 674 LIIPSL--ERL------VNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKE 725
Query: 130 RSSYQDKVERLNQELNHI 147
+Y ++ + N +++H+
Sbjct: 726 AINYSQQLAKANLKIDHL 743
Score = 36.6 bits (83), Expect = 0.024
Identities = 37/187 (19%), Positives = 76/187 (40%), Gaps = 15/187 (8%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANL------AQLLRDSQDRNKHLGEEIKEL 57
QL+E H+ KK + ++ L + +K++ AQ +S+ + ++ L
Sbjct: 1671 QLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERL 1730
Query: 58 QQRLGEVQGDNKLL---------RMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQ 108
+ +L + K L MT A + A + + ++ + + K Q
Sbjct: 1731 KSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQ 1790
Query: 109 IESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYL 168
+E L +L + L+ K +S D + LN EL + + + + + EN L
Sbjct: 1791 VEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDEL 1850
Query: 169 QERLKQL 175
+ ++K+L
Sbjct: 1851 KRQIKRL 1857
Score = 35.8 bits (81), Expect = 0.040
Identities = 37/187 (19%), Positives = 89/187 (47%), Gaps = 30/187 (16%)
Query: 15 KYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEV---------- 64
K +EL + + + + +L QL++++ +R + + + ++L+Q++ +
Sbjct: 2278 KLKEL---ETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETE 2334
Query: 65 QGDNKLLR-MTIAKQRLGDEAIGVRHFAAHER-----EDLVQQLERAKEQIESLEHDLQA 118
QG + L+ + +A +L E + H + E + ++ KE+I+ LE L+
Sbjct: 2335 QGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKM 2394
Query: 119 SVDELQDVKEERSSYQDKVERLN----QELNHILSGHENRIIDVDALCMENRYLQERLKQ 174
S E Q +KEE + ++E + +E+ + ++ + +N L+E++K+
Sbjct: 2395 SDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEV-------KKNILLEEKVKK 2447
Query: 175 LHEEVNL 181
L E++ +
Sbjct: 2448 LSEQLGV 2454
Score = 34.3 bits (77), Expect = 0.12
Identities = 57/286 (19%), Positives = 126/286 (44%), Gaps = 27/286 (9%)
Query: 4 QLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR-LG 62
++ + + LK++ + L G P KQ+ + +L R + L +++E+ + +
Sbjct: 1842 EIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMK 1901
Query: 63 EVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHERED---LVQQLERAKEQIE-------SL 112
E +L+R K+ + G+R+ + + L +QL K+ +L
Sbjct: 1902 EKNAKEELIRWEEGKKWQA-KIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTL 1960
Query: 113 EHDLQAS---VDELQDVKEERSSYQ-DKVERLNQEL-NHILSGHENRIIDVDA----LCM 163
+ L+ + VD++ ++ S + +++++ N +L N IL ++ + D+ L +
Sbjct: 1961 QRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHL 2020
Query: 164 ENRYLQERLKQLHEEVNLLKSNIAKYK-NALERRKNSKGQGKSSSSALTGVLSAKQVQ-D 221
+NRYLQE+L L ++ + K +K + +E + + + + L LS++ ++
Sbjct: 2021 QNRYLQEKLHALEKQFS--KDTYSKPSISGIESDDHCQREQELQKENLK--LSSENIELK 2076
Query: 222 LLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNK 267
E LP + DLK + L + E + H R + +
Sbjct: 2077 FQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGR 2122
Score = 32.3 bits (72), Expect = 0.44
Identities = 43/195 (22%), Positives = 79/195 (40%), Gaps = 17/195 (8%)
Query: 9 HQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHL----GEEIKELQQRLGEV 64
H +LK ++ + + L ++ +LL +++ + + E++ L RL E+
Sbjct: 1532 HHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRL-EL 1590
Query: 65 QGDNKLLRMTIAKQRLGDEAIGV----RHFAAHEREDLVQQLERAKEQIESLEHDLQASV 120
Q D+ L + L ++ +HF L + + EQ +SL L
Sbjct: 1591 QADSSLNKFKQTAWDLMKQSPTPVPTNKHFIR-----LAEMEQTVAEQDDSLSSLLVKLK 1645
Query: 121 DELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN 180
QD++ +R + KV+ + HE+ + V A + +YL L Q +E
Sbjct: 1646 KVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYL---LDQSQKESQ 1702
Query: 181 LLKSNIAKYKNALER 195
LKS + K A R
Sbjct: 1703 CLKSELQAQKEANSR 1717
Score = 30.4 bits (67), Expect = 1.7
Identities = 49/238 (20%), Positives = 93/238 (39%), Gaps = 48/238 (20%)
Query: 5 LRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEV 64
L E LKKK R++ E+ K++ + L + + +++ + G+
Sbjct: 545 LEEERLDLKKKIRQMAQ-------ERGKRSATSGLTTEDLNLTENISQ---------GDR 588
Query: 65 QGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDE-- 122
+ KL +++ EA F + E + + LER++ I ++ L+ V+E
Sbjct: 589 ISERKLDLLSLKNM---SEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENK 645
Query: 123 ---------LQDVKEERSSYQDK-------VERLNQELNHILSGHENRIID--------V 158
LQ +KE + K + L + +N I S + I D V
Sbjct: 646 QLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQV 705
Query: 159 DALCMENRYLQERLKQLHEEVNLLKSNIAKYK---NALERRKNSKGQGKSSSSALTGV 213
D L N L++ L++ +E +AK + LE+ + Q + S+ G+
Sbjct: 706 DQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGI 763
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.338
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,359,242
Number of Sequences: 37866
Number of extensions: 404670
Number of successful extensions: 6043
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 296
Number of HSP's successfully gapped in prelim test: 662
Number of HSP's that attempted gapping in prelim test: 2852
Number of HSP's gapped (non-prelim): 2759
length of query: 267
length of database: 18,247,518
effective HSP length: 100
effective length of query: 167
effective length of database: 14,460,918
effective search space: 2414973306
effective search space used: 2414973306
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.